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Transient regimes in a heavy water reactor; Regimes transitoires dans un reacteur a eau lourde

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Raievski, V [Commissariat a l' Energie Atomique, Saclay(France). Centre d' Etudes Nucleaires

1953-07-01

We studied the variations of power and reactivity of a reactor when we raise in a continuous way the starting plates. During the subcritical regime (negative reactivity), the power is determined by reactivity and by the intensity of the sources of photo neutrons, produced during the previous work of the reactor. When, during the rise of the plates, the reactor, pass by the critical regime (zero reactivity), one notes that the reached power is independent of the initial reactivity. During the sur-critical regime (positive reactivity), the elevation of temperature of the uranium bars slows down the growth of reactivity due to the movements of the plates. The power stretches then toward a value that depends only on the regime of cooling of the reactor and the excess of the available reactivity. This survey permits to choose such a rise speed, that reactivity remains constantly lower to a value beyond which the piloting of the reactor becomes difficult. This result is not more valid, if the intensity of the sources is insufficient, what takes place during the first divergences and after a stop of long length. (author) [French] On etudie les variations de puissance et de reactivite d'un reacteur quand on leve d'une facon continue les plaques de demarrage. Pendant le regime subcritique (reactivite negative), la puissance est determinee par la reactivite et par l'intensite des sources de photoneutrons, produites pendant la marche anterieure du reacteur. Quand, au cours de la montee des plaques, le reacteur passe par le regime critique (reactivite nulle), on constate que la puissance atteinte est independante de la reactivite initiale. Pendant le regime surcritique (reactivite positive), l'elevation de temperature des barres d'uranium ralentit l'accroissement de reactivite due aux mouvements des plaques. La puissance tend alors vers une valeur qui ne depend plus que du regime de refroidissement du reacteur et de l'exces de la reactivite disponible. Cette etude permet de
Prospects for the Use of Plutonium in Reactors; Prospective d'Utilisation du Plutonium dans les Reacteurs

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Fossoul, E.; Haubert, P. [BELGONUCLEAIRE (Belgium); Hirschberg, D.; Morlet, E. [International Business Machines of Belgium, Bruxelles (Belgium)

1967-09-15

son acquisition a l'exterieur, ce qui permet de faire une bonne approximation et d'eliminer la grande inconnue du prix de marche du plutonium dans les decennies a venir. Etant donne pour ce systeme une politique d'implantation de centrales nucleaires, c'est-a-dire un ensemble de decisions d'installer des centrales de type et de puissance donnes a des dates donnees, les techniques de programmation lineaire permettent d'optimiser l'utilisation du plutonium produit de facon a minimiser le cout total actualise de la production cumulee d'energie electrique pendant une periode determinee. Une etape ulterieure est l'optimisation, par des techniques differentes, non seulement de l'utilisation mais aussi de la production de plutonium, et cela en choisissant les types de reacteurs a installer dans les differentes centrales. (author)
Preliminary studies of the kinetics of a reactor by the probability method; Etude preliminaire de la cinetique d'un reacteur par la methode des probabilites

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Bruna, J G; Brunet, J P; Clouet D' Orval, Ch; Caizergues, R; Verriere, Ph [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

The {alpha} decay constant of prompt neutrons has been studied in the homogeneous plutonium-fueled, light-water-moderated reactor Alecto, by the probability method. In this method, the probability to count one, two,.... neutrons during a given time is measured. The value of {alpha} can be deduced from this measurement, for various subcritical states of the reactor. The experimental results were then compared with values obtained, for the same reactivities, by the pulsed neutron technique. (authors) [French] On a etudie sur Alecto, reacteur homogene au plutonium, modere a l'eau legere, la constante de decroissance {alpha} des neutrons prompts par la methode des probabilites. Celle-ci consiste a mesurer la probabilite de compter un, deux, etc..., neutrons pendant un intervalle de temps donne. On a pu en deduire la valeur de {alpha}, dans divers etats sous-critiques du reacteur. On a compare les resultats experimentaux a d'autres valeurs obtenues, aux memes reactivites, par la methode des neutrons pulses. (auteurs)
Nuclear reactor (1960); Reacteurs nucleaires (1960)

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Maillard, M L [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires; Leo, M B [Electricite de France (EDF), 75 - Paris (France)

1960-07-01

The first French plutonium-making reactors G1, G2 and G3 built at Marcoule research center are linked to a power plant. The G1 electrical output does not offset the energy needed for operating this reactor. On the contrary, reactors G2 and G3 will each generate a net power of 25 to 30 MW, which will go into the EDF grid. This power is relatively small, but the information obtained from operation is great and will be helpful for starting up the power reactor EDF1, EDF2 and EDF3. The paper describes how, previous to any starting-up operation, the tests performed, especially those concerned with the power plant and the pressure vessel, have helped to bring the commissioning date closer. (author) [French] Les premiers reacteurs industriels plutonigenes francais G1 - G2 - G3 du Centre de Marcoule comportent une installation de recuperation d'energie. La production d'electricite de G1 ne compense pas l'energie depensee par ailleurs pour le fonctionnement de l'ensemble, par contre, G2 et G3 doivent fournir chacun une puissance de 25 a 30 MW au reseau national d'Electricite de France. Cette puissance est modeste, mais l'experience acquise grace a ces reacteurs est tres grande et c'est grace a elle qu'il nous sera possible de mettre en exploitation les reacteurs energetiques EDF1 - EDF2 - EDF3. Le memoire decrit comment, avant tout demarrage du reacteur, les essais effectues, en particulier ceux concernant l'installation de recuperation d'energie et le caisson, ont permis d'abreger la phase de montee en puissance. (auteur)
Detection and location of can rupture in reactors cooled by a flow of water; Detection et localisation des ruptures de gaines sur les reacteurs refroidis par circulation d'eau

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Le Meur, R [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1968-07-01

This report brings together the principal methods of fission-product detection used for water reactors. The position, type and method of adjustment is given for each detector. The methods for localizing the defective elements are explained, in particular those using water sampling or decreases in the flux. A few installations are briefly described. They correspond to particular types of reactors using boiling, pressurized or cold water. Amongst the many methods used, it can be noted that when the fuel is resistant, the installations are fairly compact. In nuclear super-heated reactors on the other hand, the study of fuel behaviour calls for larger installations. An identification of defective elements exists when the reactor structure allows it. If this is not possible, a localization in a group of elements is obtained by a flux depression. (author) [French] Ce rapport rassemble les principales methodes de detection de produits de fission utilisees pour des reacteurs a eau. On indique pour les detecteurs leurs emplacements, leurs types, leurs reglages. On explique quelles sont les methodes de localisation des elements defectueux, en particulier celles utilisant des prelevements d'eau ou des depressions de flux. Quelques installations sont decrites sommairement. Elles correspondent a des types particuliers de reacteurs a eau bouillante, pressurisee ou froide. Parmi les nombreuses methodes utilisees, on constate que les installations sont peu importantes, lorsque le combustible est resistant. Par contre dans les reacteurs a surchauffe nucleaire l'etude du comportement du combustible necessite des installations plus importantes. Une identification d'elements defectueux existe lorsque la structure du reacteur le permet. A defaut une localisation dans un groupe d'elements est obtenue par depression de flux. (auteur)
Chemical elimination of alumina in suspension in nuclear reactors heavy water; Elimination de l'alumine en suspension dans l'eau lourde des reacteurs nucleaires par voie chimique

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Ledoux, A [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1967-02-01

Corrosion of aluminium in contact with moderating water in nuclear reactor leads to the formation of an alumina hydrosol which can have an adverse effect on the operation of the reactor. Several physical methods have been used in an attempt to counteract this effect. The method proposed here consists in the elimination of the aluminium by dissolution and subsequent fixation in the ionic form on mixed-bed ion-exchange resin. In order to do this, the parameters and the values of these parameters most favorable to the dissolution process have been determined. If the moderator is heavy water, the deuterated acid can be prepared by converting a solution in heavy water to a salt of the acid using a deuterated cationic resin. (author) [French] La corrosion de l'aluminium au contact de l'eau moderatrice des reacteurs nucleaires, donne lieu a la formation d'un hydrosol d'alumine nuisible au bon fonctionnement des reacteurs. Plusieurs methodes physiques ont ete mises en oeuvre pour pallier ces inconvenients. On propose ici d'eliminer l'alumine par solubilisation pour la fixer ensuite sous forme ionique par des resines echangeuses d'ions, en lit melange. A cette fin on determine les parametres et leurs grandeurs favorables a cette solubilisation. Si le moderateur est de l'eau lourde la preparation d'acide deutere peut etre effectuee par passage d'une solution en eau lourde a un sel de l'acide sur resine cationique deuteree.
Study of isotopic exchange reactors (1961); Etude des reacteurs d'echange isotopique (1961)

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Grandcollot, P; Dirian, G [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1961-07-01

conduit a definir le quotient du reacteur; les performances de ce reacteur sont caracterisees par son efficacite globale. La notion de rapport est introduite du fait que celui i constitue un intermediaire de calcul commode. La recherche d'une grandeur additive pour des reacteurs places en serie conduit logiquement a definir une capacite d'echange, et une efficacite totale, ou nombre de reacteurs theoriques. Cette maniere d'exprimer les performances d'un reacteur est plus generale que l'efficacite de Murphree, qui n'a de sens physique que dans le cas particulier des reacteurs a liquide homogene. On exprime les relations entre ces diverses grandeurs, et on generalise la representation de Me Cabe et Thiele. Les performances du reacteur sont reliees a la cinetique de la reaction du premier ordre par l'intermediaire du nombre de transfert. Les relations sont exprimees pour un certain nombre de cas particuliers concrets. Enfin, on indique l'application de ces calculs, et les approximations necessaires, au cas ou, a cause de la presence de plusieurs constituants dans chacune des phases, la reaction d'echange n'obeit plus a une cinetique unique. (auteurs)
G2 and G3 reactors design; Description des reacteurs G2 et G3

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Herreng,; Ertaud,; Pasquet, [Societe Alsacienne de Constructions Mecaniques (France)

1958-07-01

operating power levels of reactor. The regulating system has brought about difficult problems; experimental examination, while operating, will solve them. Special meetings will be held concerning the burst slug system and fuel elements. (author) [French] La construction des reacteurs G2 et G3, dans le cadre du premier plan quinquennal francais, a ete confiee par le C.E.A. au groupement d'industriels FRANCE-ATOME. Bien que ces reacteurs restent essentiellement plutonigenes, on a accole a chacun d'eux une centrale electrique devant fournir 40 MW, dont la responsabilite a ete assumee par l'E.D.F. Le coeur du reacteur adopte la plupart des solutions du reacteur G1 (excepte la fente centrale): canaux horizontaux, empilement de briques parallelepipediques de graphite, protection thermique en acier. Le refroidissement est assure par du gaz carbonique sous 15 atmospheres. Cette pression est tenue par un caisson en beton precontraint, ayant la forme d'un cylindre horizontal. Des cables d'acier sous tension entourent le cylindre de beton, dont ils sont isoles par des patins. Les fonds du cylindre ont pose des problemes particuliers qui ont conduit a la forme hemispherique adoptee. L'etancheite du caisson est assuree par une tole de 30 mm liee a la face interne du beton. Un des aspects les plus originaux de ces reacteurs est la possibilite de charger et decharger en marche. Cote chargement, des sas a barillets, pesant chacun 50 tonnes; permettent de faire passer les cartouches neuves sous la pression de 15 atmospheres. Ces cartouches progressent de facon quasi continue dans le canal pour tomber finalement par des goulottes inclinees et des toboggans helicoidaux dans un nouveau sas. La circulation du gaz carbonique est assuree par trois turbo-soufflantes, actionnees elles-memes par la vapeur moyenne pression obtenue dans echangeurs, chaque reacteur alimente quatre echangeurs ayant pose de difficiles problemes de construction et de mise en place. Le cycle secondaire est un cycle
Developpement d'une methode de Monte Carlo dependante du temps et application au reacteur de type CANDU-6

Science.gov (United States)

Mahjoub, Mehdi

La resolution de l'equation de Boltzmann demeure une etape importante dans la prediction du comportement d'un reacteur nucleaire. Malheureusement, la resolution de cette equation presente toujours un defi pour une geometrie complexe (reacteur) tout comme pour une geometrie simple (cellule). Ainsi, pour predire le comportement d'un reacteur nucleaire,un schema de calcul a deux etapes est necessaire. La premiere etape consiste a obtenir les parametres nucleaires d'une cellule du reacteur apres une etape d'homogeneisation et condensation. La deuxieme etape consiste en un calcul de diffusion pour tout le reacteur en utilisant les resultats de la premiere etape tout en simplifiant la geometrie du reacteur a un ensemble de cellules homogenes le tout entoure de reflecteur. Lors des transitoires (accident), ces deux etapes sont insuffisantes pour pouvoir predire le comportement du reacteur. Comme la resolution de l'equation de Boltzmann dans sa forme dependante du temps presente toujours un defi de taille pour tous types de geometries,un autre schema de calcul est necessaire. Afin de contourner cette difficulte, l'hypothese adiabatique est utilisee. Elle se concretise en un schema de calcul a quatre etapes. La premiere et deuxieme etapes demeurent les memes pour des conditions nominales du reacteur. La troisieme etape se resume a obtenir les nouvelles proprietes nucleaires de la cellule a la suite de la perturbation pour les utiliser, au niveau de la quatrieme etape, dans un nouveau calcul de reacteur et obtenir l'effet de la perturbation sur le reacteur. Ce projet vise a verifier cette hypothese. Ainsi, un nouveau schema de calcul a ete defini. La premiere etape de ce projet a ete de creer un nouveau logiciel capable de resoudre l'equation de Boltzmann dependante du temps par la methode stochastique Monte Carlo dans le but d'obtenir des sections efficaces qui evoluent dans le temps. Ce code a ete utilise pour simuler un accident LOCA dans un reacteur nucleaire de type
Neutron noise in nuclear reactors; Le bruit neutronique des reacteurs nucleaires

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Blaquiere, A. [Institut National des Sciences et Techniques Nucleaires (France); Pachowska, R. [Universite Technique de Varsovie (Poland)

1961-06-15

The power of a nuclear reactor, in the operating conditions, presents fluctuations due to various causes. This random behaviour can be included in the study of 'noises'. Among other sources of noise, we analyse hereafter the fluctuations due: a) to the discontinuous emissions of neutrons from an independent source; b) to the multiplication of neutrons inside the reactor. The method which we present makes use of the analogies between the rules governing a nuclear reactor in operation and a number of radio-electrical systems, in particular the feed-back loops. The reactor can be characterized by its 'passing band' and is described as a system submitted to a sequence of random pulses. In non linear operating condition, the effect of neutron noise is defined by means of a non-linear functional, this theory is thus related to previous works the references of which are given at the end of the present report. This leads us in particular in the case of nuclear reactors to some results given by A. Blaquiere in the case of radio-electrical loops. (author) [French] La puissance d'un reacteur nucleaire, dans les conditions du regime, est affectee de fluctuations dont les causes sont tres diverses. Ce comportement aleatoire rentre dans le cadre general de l'etude des 'bruits'. Entre autres sources ce bruit, nous analysons ici les fluctuations dues: a) a l'emission discontinue des neutrons provenant d'une source autonome; b) a la multiplication des neutrons au sein du reacteur. La methode que nous introduisons exploite les analogies entre les lois qui regissent un reacteur nucleaire au regime et certains systemes radioelectriques, en particulier les circuits a boucle de reaction. Le reacteur est caracterise par sa 'bande passante' et est decrit comme un systeme soumis a une succession d'impulsions aleatoires. Dans les conditions de fonctionnement non lineaires, l'effet du bruit neutronique est precise en utilisant une fonctionnelle non lineaire, ce qui relie cette theorie a
Containment for Heavy-Water Gas-Cooled Reactors; Le Confinement des Reacteurs a Eau Lourde Refroidis par Gaz

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Verstraete, P.; Lehmann, D.; Lafitte, R. [Bonard et Gardel, Ingenieurs-Conseils, Lausanne (Switzerland)

1967-09-15

par gaz sont passes en revue dans le but d'etablir les specifications des enceintes de confinement en fonction des conditions des sites disponibles en Suisse pour la construction de centrales nucleaires. Ces specifications sont etablies d'apres les taux de dose consideres comme admissibles pour les populations vivant aux environs de la centrale en cas d 'accident grave du reacteur, en se basant sur des conditions meteorologiques et demographiques representatives de la plupart des sites du pays. Differents modes de construction de l ' enceinte de confinement, prenant en consideration les conditions qui s'etablissent dans l'enceinte a la suite de l'accident maximal concevable du reacteur, sont consideres. Les enceintes etudiees sont les suivantes: beton precontraint; beton precontraint avec coupole d'acier; beton precontraint avec peau d' etancheite interieure en acier; acier avec ecran lateral en beton pour la protection contre les radiations; et double confinement. Le degre d'etancheite des enceintes etudiees a ete considere comme une caracteristique lie e au mode de construction particulier et non comme une valeur prescrite en vue de laquelle la construction devait etre adaptee. Les caracteristiques d'etancheite de chaque enceinte sont estimees et les prix de chaque construction ont ete determines sur la base de plans precis avec le concours de diverses entrepises specialisees. L'estimation de l'efficacite des differentes enceintes, sous l'an gle de la securite, a ete faite en prenant en consideration differentes procedures en cas d' accident parmi lesquelles on citera principalement le rejet atmospherique, au travers de filtres adequats, et la decontamination de l 'atmosphere de l 'enceinte par recyclage dans des batteries de filtres. Une dizaine de cas, correspondant a differentes combinaisons de modes de construction et procedures en cas d'accident, font l 'objet d'une comparaison tres detaillee qui a ete realisee grace a un programme pour ordinateur electronique
Detection of burst cans in the reactors cooled by gaseous phase; Detection des ruptures de gaine dans les reacteurs refroidis par phase gazeuse

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Labeyrie, J; Roguin, A [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1955-07-01

In a nuclear reactor including the bars or plates cooled by a gaseous fluid, burst risks to occur in the sheath assuring the tightness separation between the cooling gas and the fissile materials. It is necessary to be able to detect the formation of these cracks as possible in order to avoid all risk of fission products release or any reaction of uranium to the contact of the refrigerating gas. It is however the increase of the radioactivity in the cooling gas due to the scattering of the fission products that permits to signal the apparition of a crack or to follow its evolution. It is possible to detect cracks of the order of the square millimeter. In this report, we will detail the principle and the realization of a device used for the surveillance of a natural uranium reactor cooled by air circulation. (M.B.) [French] Dans un reacteur nucleaire comportant des barres ou des plaques refroidies par un fluide gazeux des fissures risquent de se produire dans les gaines assurant la separation etanche entre le gaz de refroidissement et les materiaux fissiles. II est necessaire de pouvoir detecter la formation de ces fissures des que possible afin d'eviter tout risque de liberation de produits de fission ou de reaction de l'uranium au contact du gaz refrigerant. C'est cependant l'augmentation de la radioactivite du gaz de refroidissement due a la dispersion des produits de fission qui permet de signaler l'apparition d'une fissure ou de suivre son evolution. On peut ainsi detecter des fissures de l'ordre du millimetre carre. Dans ce rapport, nous detaillerons le principe et la realisation d'un appareil utilise pour la surveillance d'un reacteur a uranium naturel refroidi par circulation d'air. (M.B.)
Neutron detection in an atomic reactor core using semi-conductors; Detection des neutrons par semi-conducteur dans un coeur de reacteur atomique

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Divoux, F [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1968-07-01

In this paper, the first part describes the principle of nuclear particle detection by means of semiconductor diodes and the general application of these. The second part describes fabrication of the device used to estimate thermic neutron fluxes in core of a swimming pool type reactor. The useful volume (2.9 mm thickness) is in the light water moderator, between combustible elements plates. The results, principally obtained in the core of Siloette reactor at the 'Centre d'Etudes Nucleaires de Grenoble' at low power, are mentioned in the third part. Flux maps have been set and comparison between converter's products: Bore 10, Lithium 6, Uranium 235 is made. (author) [French] Dans ce rapport, une premiere partie porte sur la description du principe de detection des particules nucleaires par diodes a semi-conducteur et sur l'application generale de celles-ci. Une deuxieme partie s'attache a decrire la fabrication du materiel utilise pour evaluer les flux de neutrons thermiques dans un coeur de reacteur type pile piscine. L'espace de mesure (2,9 mm d'epaisseur) se situe entre les plaques des elements combustibles, dans le moderateur eau legere. Les resultats, obtenus principalement dans le coeur du reacteur Siloette du Centre d'Etudes Nucleaires de Grenoble aux basses puissances de fonctionnement, sont rapportes dans la troisieme partie. Des cartes de flux ont ete dressees et une comparaison est faite entre les produits 'convertisseurs' suivants: Bore 10, Lithium 6, Uranium 235. (auteur)
Considerations concerning the reliability of reactor safety equipment; Considerations sur la fiabilite des ensembles de securite de reacteurs

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Furet, J; Guyot, Ch [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1967-07-01

donne les resultats d'une analyse de fiabilite previsionnelle lorsque l'on utilise les elements fonctionnels en boitiers modulaires developpes industriellement en France. L'amelioration de cette fiabilite semble assez limitee par une augmentation de la redondance, par contre, on montre comment elle peut etre tres nettement amelioree par l'emploi de systemes de recherche automatique de pannes a des frequences tres differentes pour les sous-ensembles de mesure et les sous-ensembles logiques. Enfin, on montre sur des exemples l'incidence sur la fiabilite de la complexite et de l'emploi de technologies differentes dans les ensembles de securite de reacteurs. (auteurs)
Concept of transfer functions for a nuclear reactor; Notion de fonction de transfert pour un reacteur nucleaire

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Dalfes, Abdi [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires. Departement d' Electronique Generale, Service d' Electronique des Reacteurs

1966-07-01

The solution to the correlation equations are expressed in terms of the eigenvalues and Eigen-matrices of the transport operator, for a subcritical zero power reactor. This allows to define, for each point of the reactor and for detectors detecting neutrons of given velocities, correlation and transfer functions driven by the same white-noise source. A precise meaning is also given to the importance operator, which is the adjoin of the transport operator. (author) [French] La solution des equations regissant les matrices de correlation est exprimee en fonction des valeurs et matrices propres de l'operateur de transport pour un reacteur sous-critique et de puissance nulle. Ceci permet de definir, en chaque point du reacteur et pour des detecteurs repondant a des neutrons de vitesse definie, des fonctions de correlation et de transfert dont les entrees sont attaquees par une meme source de bruit blanc. Le role joue par l'operateur importance, adjoint de l'operateur de transport, est aussi precise. (auteur)
Contribution to the study of the stability of water-cooled reactors; Contribution a l'etude de la stabilite des reacteurs refroidis par de l'eau

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Coudert, C [Commissariat a l' Energie Atomique, Cadarache (France). Centre d' Etudes Nucleaires

1969-06-01

This work is devoted to the study of the stability of reactors cooled by water subjected only to natural convection. It is made up of two parts, a theoretical study and experimental work, each of these parts being devoted to a consideration of linear and non-linear conditions: - calculation of the transfer function of the reactor using neutronic and hydrodynamic linear equations with the determination of the instability threshold; - demonstration of the existence of the limiting oscillation cycle in the case of a linear feedback using MALKIN'S method; - measurement and interpretation of the reactor's transfer functions and of the hydrodynamic transfer functions; and - analysis of the noise due to boiling. (author) [French] Dans ce travail on etudie la stabilite des piles refroidies par de l'eau circulant en convection naturelle. Cette etude se divise en deux parties: un travail theorique et un travail experimental, chacune de ces parties comportant une etude lineaire et une etude non-lineaire: - calcul de la fonction de transfert du reacteur a partir des equations lineaires de la neutronique et de l'hydrodynamique avec determination du seuil d'instabilite; - demonstration de l'existence du cycle limite des oscillations dans le cas d'une retroaction lineaire en utilisant la methode de MALKIN; - mesure et interpretation de la fonction de transfert du reacteur et des fonctions de transfert hydrodynamiques; et - analyse du bruit d'ebullition. (auteur)
Problems related with the power regulation of reactors by physico-chemical methods, and the behaviour of water and heavy water in nuclear reactors; Comportement de l'eau et de l'eau lourde dans les reacteurs nucleaires et problemes de la regulation de puissance par voie physico-chimique

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Dolle, L; Conan, D; Dirian, G [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

Experience of the CEA heavy water reactors and a systematic study of the radiolytic decomposition of water in the core of swimming-pool reactors are described. Setting up of reactivity control by physico-chemical methods. Reactivity control by homogeneous poisoning of the reactor A comparison of the evolution of xenon poisoning with the residual anti reactivity of the poison in solution during its nuclear consumption establishes the programme which must govern the variation in its concentration if the exact compensation is to be produced The behaviour of the poison towards the reactor materials under the particular operational conditions must be taken into account. Radiolytic decomposition of water in the reactors in the presence of soluble poisons: A study of the effect of certain chemically inert salts, present in small concentrations in the water, on its radiolytic decomposition rate, has led to some new results which are discussed. The choice of a soluble poison is justified on the basis of the above results. Reactivity control by the use of a gaseous absorbent The use of a gas control rod circuit for compensation purposes, in place of solid control rods is described. The use of soluble poisons in the moderator to compensate the xenon effect, and of a gaseous absorbent in a circuit known as a gas control rod form original aspects of the reactivity control in the reactor EL 4. (authors) [French] L'observation du comportement de l'eau et de l'eau lourde dans les reacteurs en exploitation, contribue au fonctionnement sur de ceux-ci et oriente certaines etudes relatives aux techniques de controle de la reactivite par mise en oeuvre de poisons solubles. L'utilisation de poisons nucleaires dissous dans l'eau du reacteur entraine une pollution chimique de celle-ci. Les conditions d'emploi permettant d'eviter les effets indesirables de cette pollution sont etudiees. Les problemes analytiques - bien qu'importants - ne sont pas abordes dans le cadre de la communication
Study relating to the physico-chemical behaviour of heavy water in nuclear reactors; Etudes relatives au comportement physico-chimique de l'eau lourde dans les reacteurs nucleaires

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Chenouard, J; Dirian, G; Roth, E; Vignet, P; Platzer, R [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1959-07-01

Chemical and isotope pollution, and radiolytic decomposition are the two most important ways in which heavy water becomes degraded in nuclear reactors. Chemical pollution has led to the creation of ion exchange purification loops specially designed for reactors: the report contains a description in detail of the application of this purification method in CEA research reactors, including the analysis required, results obtained, and their interpretation. The intelligence obtained on radiolytic decomposition with the same facilities is also discussed, as well as the recombination apparatus and control equipment utilized. Finally, investigation to date in the CEA on recombination circuits for power reactors is also discussed. (author) [French] Parmi les degradations subies par l'eau lourde dans les reacteurs nucleaires, les deux plus importantes sont la pollution chimique et isotopique et la decomposition radiolytique. La pollution chimique a conduit a mettre au point pour le cas particulier des reacteurs, des circuits d'epuration par echange d'ions. On decrit ici en detail la mise en oeuvre de cette methode dans les reacteurs de recherche du CEA; les controles qu'elle necessite, les resultats obtenus et leur interpretation. En ce qui concerne la dissociation radiolytique de l'eau, les renseignements obtenus sur ces memes reacteurs sont communiques, ainsi que les details des dispositifs de recombinaison et des moyens de controle. Enfin, on fait le point des etudes poursuivies au CEA sur ces memes problemes de recombinaison dans le cas des reacteurs de puissance. (auteur)
Study relating to the physico-chemical behaviour of heavy water in nuclear reactors; Etudes relatives au comportement physico-chimique de l'eau lourde dans les reacteurs nucleaires

Energy Technology Data Exchange (ETDEWEB)

Chenouard, J.; Dirian, G.; Roth, E.; Vignet, P.; Platzer, R. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1959-07-01

Chemical and isotope pollution, and radiolytic decomposition are the two most important ways in which heavy water becomes degraded in nuclear reactors. Chemical pollution has led to the creation of ion exchange purification loops specially designed for reactors: the report contains a description in detail of the application of this purification method in CEA research reactors, including the analysis required, results obtained, and their interpretation. The intelligence obtained on radiolytic decomposition with the same facilities is also discussed, as well as the recombination apparatus and control equipment utilized. Finally, investigation to date in the CEA on recombination circuits for power reactors is also discussed. (author) [French] Parmi les degradations subies par l'eau lourde dans les reacteurs nucleaires, les deux plus importantes sont la pollution chimique et isotopique et la decomposition radiolytique. La pollution chimique a conduit a mettre au point pour le cas particulier des reacteurs, des circuits d'epuration par echange d'ions. On decrit ici en detail la mise en oeuvre de cette methode dans les reacteurs de recherche du CEA; les controles qu'elle necessite, les resultats obtenus et leur interpretation. En ce qui concerne la dissociation radiolytique de l'eau, les renseignements obtenus sur ces memes reacteurs sont communiques, ainsi que les details des dispositifs de recombinaison et des moyens de controle. Enfin, on fait le point des etudes poursuivies au CEA sur ces memes problemes de recombinaison dans le cas des reacteurs de puissance. (auteur)
Operational experience of the Marcoule reactors; Experience d'exploitation des reacteurs de Marcoule

Energy Technology Data Exchange (ETDEWEB)

Conte, F [Commissariat a l' Energie Atomique, Centre de Production de Plutonium, Marcoule (France). Centre d' Etudes Nucleaires

1963-07-01

The results obtaining from three years operation of the reactors G-2, G-3 have made it possible to accumulate a considerable amount of operational experience of these reactors. The main original points: - the pre-stressed concrete casing - the possibility of loading while under power - automatic temperature control have been perfectly justified by the results of operation. The author confirms the importance of these original solutions and draws conclusions concerning the study of future nuclear power stations. (author) [French] Les resultats atteints apres trois ans de fonctionnement des reacteurs G-2/G-3 permettent une accumulation considerable de l'experience d'exploitation de ces reacteurs. Les principales originalites: - caisson en beton precontraint - chargement en marche - surveillance automatique des temperatures sont largement justifiees par l'exploitation actuelle. L'auteur confirme l'interet de ces solutions d'avant-garde et en tire des conclusions pour les etudes de futures centrales nucleaires. (auteur)

The dangers of irradiate uranium in nuclear reactors; Les dangers de l'uranium irradie dans les reacteurs nucleaires

Energy Technology Data Exchange (ETDEWEB)

Jammet, H; Joffre, H [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1955-07-01

The danger of the uranium cans sur-activated by the use in the nuclear reactors is triple: - Irradiation from afar, during manipulations of the cans. - Contamination of air when decladding. - Contamination of air by fire of uranium in a reactor in function The first two dangers are usual and can be treated thanks to the rules of security in use in the atomic industry. The third has an accidental character and claimed for the use of special and exceptional rules, overflowing the industrial setting, to reach the surrounding populations. (authors) [French] Le danger des cartouches d'uranium suractive par utilisation dans les reacteurs nucleaires est triple: - Irradiation a distance, lors des manipulations des cartouches. - Contamination de l'air au moment de leur degainage. - Contamination de l'air par incendie d'uranium dans un reacteur en fonctionnement. Les deux premiers dangers sont habituels et peuvent etre traites grace aux regles de securite en usage dans l'industrie atomique. Le troisieme revet un caractere accidentel et reclame l'emploi de regles speciales et exceptionnelles, debordant le cadre industriel, pour atteindre celui des populations environnantes. (auteurs)
Determination of local boiling in light water reactors by correlation of the neutron noise; Determination de l'ebullition locale dans les reacteurs a eau legere par correlation du bruit neutronique

Energy Technology Data Exchange (ETDEWEB)

Zwingelstein, G [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1968-07-01

The power limit of swimming-pool type reactors depends on the phenomenon of the appearance of burn-out. In order to determine this limit we have attempted to detect the local boiling which usually occurs before the burn out. Local boiling has been simulated by an electrically heated plate placed in the core of the reactor Siloette. The study of local boiling, which is based on the properties of the correlation functions for the neutron noise of detectors placed in the core, shows that a privileged frequency occurs in the power spectrum of the noise. It is intended in the future to determine the influence of various parameters on this characteristic frequency. (author) [French] La limitation de la puissance des reacteurs nucleaires de type piscine est due au phenomene d'apparition de 'burn out'. Pour determiner cette limitation, nous nous sommes proposes dans ce rapport de detecter l'ebullition locale qui apparait generalement avant le 'burn out'. L'ebullition locale a ete simulee par une plaque chauffee electriquement et placee dans le coeur du reacteur SILOETTE. L'etude de l'ebullition locale, qui est basee sur les proprietes des fonctions de correlation du bruit neutronique de detecteurs places clans le coeur, fait apparaitre une frequence privilegiee dans le spectre de puissance du bruit. On envisage dans l'avenir, de determiner l'influence des divers parametres sur cette frequence caracteristique. (auteur)
Heavy water reactors physics; Physique des reacteurs a eau lourde

Energy Technology Data Exchange (ETDEWEB)

Girard, Y; Lourme, P; Naudet, R [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

An important research programme on heavy water reactor physics has been carried out in France for quite a few years. The decision to build the EL 4 prototype and so to choose the heavy water gas cooled type has renewed the interest in this programme and at the same time given to it a more specific orientation A summary of the results gained in this field is presented in this paper. In the first part are described the experimental investigations, most of them were carried out in the criticality facility AQUILON II. The experiments are grouped in four parts - Systematic studies of lattices Buckling measurements. - Specific studies of gas-cooled lattices. - Fine structure, spectral indices measurements etc... - Measurements on lattices or samples containing Uranium of various enrichment or Plutonium. The second part is devoted to a summary of the theoretical studies. The whole results have allowed an improvement of the calculation methods, have led to a better understanding of the neutron balance in lattices, and have permitted the establishment of a set of formula to predict not only the clean fuel conditions but also the evolution of the nuclear properties with irradiation. Some specific studies on power reactor are quoted. (authors) [French] Un important programme d'etudes sur la physique des reacteurs a eau lourde est mene en France depuis assez longtemps. La decision de construire le prototype EL 4 et de s'engager ainsi dans la filiere des reacteurs a eau lourde refroidis par gaz a redonne un nouvel interet a ce programme et l'a en meme temps oriente dans une direction plus particuliere. La presente communication, rassemble les resultats des etudes faites dans ce domaine depuis la derniere conference de Geneve. Dans la premiere partie on decrit les etudes experimentales dont la plupart ont ete effectuees dans la pile d'experiences critiques Aquilon II. Les experiences sont groupees en quatre ensembles: etude systematique de reseaux (mesures de laplaciens) etudes
Burnup determination of power reactor fuel elements by gamma spectrometry; Determination par spectrometrie {gamma} du taux d'irradiation des elements combustibles des reacteurs de puissance

Energy Technology Data Exchange (ETDEWEB)

Robin, M; Jastrzeb, M; Boisliveau, S; Boyer, R; Vidal, R [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

1969-07-01

This report describes a method for determining by {gamma} spectrometry the burn up and the specific power of fuel elements irradiated in power reactors. The energy spectrum of {gamma} rays emitted by fission products is measured by means of a simple equipment using a sodium iodide detector and a multichannel analyzer. In order to extract from the spectrum a quantity proportional to the burn up, it is necessary to: - isolate an activity specific of one emitter,- give the same importance to fissions in uranium and plutonium - take into account the radioactive decay during and after irradiation. One hundred fuel elements were studied and burn up values obtained by {gamma} spectrometry are compared to results given by chemical analyses. Preliminary measurements show that the accuracy of the results is greatly increased by the use of a germanium detector, due to its good resolution. (authors) [French] Ce rapport expose une methode de determination par spectrometrie {gamma} du taux d'irradiation et de la puissance specifique des elements combustibles irradies dans les reacteurs de puissance. Une installation simple utilisant un detecteur d'iodure de sodium et un selecteur multicanaux mesure le spectre en energie du rayonnement {gamma} emis par les produits de fission. Afin d'extraire du spectre une quantite proportionnelle au taux de combustion, il faut: - isoler une activite specifique a un emetteur, - donner la meme importance aux fissions survenues dans l'uranium et le plutonium, - prendre en compte la decroissance radioactive pendant et apres l'irradiation. Les mesures ont porte sur une centaine d'elements combustibles et les taux de combustion obtenus par spectrometrie {gamma} sont compares aux resultats des analyses chimiques. Des mesures preliminaires montrent que l'utilisation d'un detecteur de germanium augmente considerablement la precision des resultats, en raison de son excellente resolution. (auteurs)
Notes on a homogeneous reactor project; Idees sur un projet de reacteur homogene

Energy Technology Data Exchange (ETDEWEB)

Benveniste, J; Bernot, J; Eidelman, D; Grenon, M; Portes, L; Raspaud, G; Tachon, J; Vendryes, G [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Berthod, L; Cohen de Lara, G; Delachanal, M; Fontanet, P; Halbronn, G [Societe Grenobloise d' Etudes et d' Applications Hydrauliques, 38 (France)

1958-07-01

'accelerer les bulles de vapeur vers le vortex axial dans lequel elles sont collectees; le debit de vapeur est alors evacue vers le systeme exterieur d'utilisation thermique, par exemple un echangeur du type condenseur-bouilleur. La vitesse d'entree de l'eau dans le reacteur etant un des parametres importants du fonctionnement, il est utilise une alimentation par bache spirale, ce qui permet de regler cette vitesse en grandeur et direction. (auteur)
Neutron flux determinations in the reactors G2 and G3 during operation; Releves du flux neutronique dans les reacteurs G2 et G3 en puissance

Energy Technology Data Exchange (ETDEWEB)

Boulinier, C; Faurot, P; Sagot, M; Teste du Bailler, A [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

1961-07-01

After demonstrating the sensitivity of the distribution of power in a production reactor to a deformation caused by dissymmetries of reactivity in the reactor, the authors describe the method of neutron flux determination devised for the reactors G2 and G3 under working conditions; the detector used is a tungsten or nickel wire, the {gamma} activity of which is measured with an ionisation chamber. Several flux determinations are given as examples to illustrate the sensitivity of the method. (author) [French] Apres avoir mis en evidence la sensibilite de la repartition de la puissance dans un reacteur de production a une deformation provoquee par de faibles dissymetries de reactivite dans le reacteur, les auteurs decrivent la methode de releve du flux neutronique mise au point pour les reacteurs G2 et G3 en puissance; le detecteur utilise est un fil de tungstene ou de nickel dont l'activite {gamma} est mesuree a l'aide d'une chambre d'ionisation. Quelques releves de flux illustrant la sensibilite de la methode sont donnes a titre d'exemple. (auteur)
The Pegase reactor loops; Les boucles du reacteur Pegase

Energy Technology Data Exchange (ETDEWEB)

NONE

1968-07-01

After 4 years operation, experimentation and maintenance of the gas loops built especially for the nuclear fuel testing reactor Pegase, it appears desirable not only to gather together in a single document the essential characteristics and particularities of these devices and of their associated equipment, but also to give the reasons for the technical modifications and the way in which they were carried out; this is done here by the persons themselves who were responsible, day after day, for operating these loops. This essentially practically experience thus complements the careful research and preliminary testing carried out on these loops or on their prototypes. It should be of interest to those who deal with problems concerned with the design or operation of irradiation loops in experimental reactors or of similar equipment. (authors) [French] Apres 4 annees de fonctionnement, d'experimentation et d'entretien sur les boucles a gaz, construites specialement pour le reacteur d'essai des combustibles nucleaires Pegase, il a paru souhaitable non seulement de rassembler dans un meme document les caracteristiques et les particularites essentielles de ces dispositifs et des appareillages qui leur sont associes, mais aussi d'y preciser les raisons et les modalites des mises au point techniques, apportees par ceux qui, jour apres jour pendant cette periode, ont eu la charge de mettre en oeuvre ces boucles. Cette experience essentiellement pratique complete donc les etudes minutieuses et les essais preliminaires de ces boucles ou de leurs prototypes. Elle doit etre de quelque interet pour ceux qui sont confrontes aux problemes de conception ou d'exploitation de boucles d'irradiation dans des reacteurs experimentaux ou des dispositifs analogues. (auteurs)
General problems arising from the analogical resolution of the kinetic equations of nuclear reactors (1961); Problemes generaux poses par la resolution analogique des equations cinetiques des reacteurs nucleaires (1961)

Energy Technology Data Exchange (ETDEWEB)

Caillet, C [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1961-07-01

The author reviews precisely the analogical techniques used for the resolution of the kinetic equations of nuclear reactors. Prior to this, he recalls the reasons which oblige physicians and engineers, even today, to use electronic machines in this domain. The author then considers the technological problems posed by the range of values which the various nuclear parameters adopt. In each case, he shows that a compromise is possible allowing an optimum precision. He compares the results to those obtained by arithmetic calculation and uses the examples chosen in a critical analysis of the present possibilities of the two methods of calculation. (author) [French] L'auteur cherche a faire un point aussi exact que possible des techniques analogiques utilisees pour resoudre les equations cinetiques des reacteurs nucleaires. Il rappelle auparavant les raisons pour lesquelles physiciens et ingenieurs sont obliges, encore aujourd'hui, de faire appel aux machines electroniques dans ce domaine. Puis il etudie les problemes technologiques que souleve le champ des valeurs prises par les differents parametres nucleaires. Dans chacun des cas, il montre l'existence d'un compromis qui permet d'atteindre une precision optimum. Il compare les resultats obtenus a ceux provenant de calculateurs arithmetiques et profite des exemples choisis pour faire une analyse critique des possibilites actuelles offertes par les deux modes de calcul. (auteur)
Economic Effect on the Plutonium Cycle of Employing {sup 235}U in Fast Reactor Start-Up; Incidence Economique du Demarrage des Reacteurs Rapides a l'Aide d'Uranium-235 sur le Cycle du Plutonium

Energy Technology Data Exchange (ETDEWEB)

Van Dievoet, J.; Egleme, M.; Hermans, L. [BELGONUCLEAIRE, Bruxelles (Belgium)

1967-09-15

factors, inventory factors) from one cycle to another, with a comparative study of the use of {sup 235}U in thermal and fast reactors, variations in the discounted fuel cycle costs from one cycle to another, and weight and characteristics of the recycled fuel, of the additional fuel required and of excess fuel. (author) [French] Le memoire presente les premiers resultats d'une etude entreprise dans le cadre d'un contrat d'association Euratom-Belgique et destinee a evaluer l'interet de l'alimentation de reacteurs rapides en uranium-235. Plusieurs possibilites se presentent pour le demarrage d'un reacteur rapide a l'aide d'uranium-235. 1. Le reacteur peut etre alimente en permanence avec de l'uranium enrichi, le plutonium produit servant a demarrer et a alimenter d'autres reacteurs; dans ce cas, l'uranium est recycle dans le reacteur en y ajoutant de l'uranium enrichi. 2. Le plutonium produit dans le reacteur peut etre partiellement recycle dans celui-ci, ainsi que l'uranium; dans ce cas, le reacteur se transforme progressivement en un reacteur au plutonium. Ces deux cas peuvent etre combines pour un reacteur a plusieurs zones d'enrichissement, ou l'on peut appliquer simultanement les deux politiques a des zones differentes, c'est-a-dire: alimenter, par exemple, la zone interne en uranium enrichi et recycler le plutonium dans la zone externe. Le mode de traitement du combustible irradie rend egalement le probleme complexe, selon que l'on traite ensemble ou separement le coeur et les couvertures axiales; de meme, pour un reacteur a plusieurs zones d'enrichissement, celles-ci peuvent etre traitees ensemble ou separement. Les calculs sont effectues a l'aide d'un code de calcul utilisant, pour lavpartie relative aux caracteristiques des reacteurs successifs, les coefficients d'equivalence definis par Baker and Ross et, pour la partie economique, la methode du cout actualise du cycle du combustible. Dans la premiere phase des travaux, une analyse approcheedu phenomene a ete
Presence of Tritium in the Cooling Circuits of the Reactors G2 and G3; Presence de tritium dans les circuits de refroidissement des reacteurs G2 et G3

Energy Technology Data Exchange (ETDEWEB)

Estournel, R [Commissariat a l' Energie Atomique. Centre de Production de Plutonium de Marcoule, 30 - Chusclan (France)

1962-07-01

In a reactor of the G 2-G 3 type, tritium can be formed by the neutronic bombardment of many elements present in the core. Tritium was found to be present in the cooling circuits of the reactors G 2 and G 3 in the water coming from the regeneration of the CO{sub 2} dehydrating columns. (author) [French] Dans un reacteur du type G 2 - G 3, le tritium peut etre forme par le bombardement. neutronique de nombreux elements existant dans le c r. La presence de tritium dans les circuits de refroidissement des reacteurs G 2 - G 3 a ete mis en evidence dans l'eau provenant de la regeneration des colonnes de deshydratation du CO{sub 2}. (auteur)
Study of a Slightly Enriched R Reactor Fuel by Means of a Pulsed Neutron Source; Etude d'un reacteur a combustible legerement enrichi (rubeole) a l'aide de sources pulsees de neutrons

Energy Technology Data Exchange (ETDEWEB)

Sagot, M; Tellier, H [Commissariat a l' Energie Atomique. Centre d' Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette (France)

1962-04-01

A Be O moderated reactor using slightly enriched uranium oxide as fuel was studied by the pulsed neutron source technique. The neutron lifetime was measured in two different cores without reflector, then attempts were made at the measurement of great negative reactivities introduced into the reactor under the following forms: decrease of the volume of the un reflected core, introduction of absorbing cadmium rods, removal of fuel at the periphery of the critical core while maintaining a constant height, and substitution of fuel elements by less reactive elements. In all cases, the results are compared with the data obtained by another type of experiment or by computation. (author) [French] Nous avons applique la methode des sources pulsees de neutrons a un reacteur utilisant de l'oxyde d'uranium legerement enrichi, modere a l'oxyde de beryllium et, apres avoir mesure le temps de vie des neutrons dans deux coeurs differents non reflechis, nous avons porte notre effort, sur la mesure de reactivites negatives importantes introduites dans le reacteur sous differentes formes: - diminution du volume du coeur non reflechi, - introduction de barres absorbantes en cadmium, - enlevement de combustible a la peripherie du coeur critique, tout en conservant une hauteur constante, - substitution d'elements de combustible par des elements moins reactifs. Dans tous les cas, les resultats sont compares aux valeurs obtenues par un autre type d'experience ou par le calcul. (auteur)
[Present conceptions of the C.E.A. concerning] the development of fast neutron reactors in France; [Les conceptions actuelles du C.E.A. concernant] la filiere des reacteurs a neutrons rapides en France

Energy Technology Data Exchange (ETDEWEB)

Vendryes, G; Gaussens, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Pasquer, R [Electricite de France (EDF), 75 - Paris (France)

1964-07-01

. (authors) [French] 1 - Situation des reacteurs a neutrons rapides dans le programme d'energie nucleaire francais. En developpant un programme base sur l'uranium naturel, la France se trouvera dotee d'un stock important de plutonium riche on isotopes superieurs. L'existence de ce plutonium et de l'uranium appauvri provenant des memes reacteurs a pour consequence logique leur emploi dans des reacteurs a neutrons rapides. Justifiee par cet interet a court terme, la mise au point de reacteurs a neutrons rapides repond par ailleurs a une necessite pour l'avenir. 2 - Enonce des caracteristiques d'une centrale a neutrons rapides de 1000 MW el. Nous indiquons les caracteristiques d'une future centrale a neutrons rapides chargee au plutonium et refroidie au sodium. Si incertaines qu'elles soient, elles constituent un guide necessaire a l'orientation de nos travaux. 3 - Etudes effectuees a ce jour: Nous donnons un apercu des etudes souvent tres preliminaires qui ont permis de retenir les caracteristiques citees plus haut. Les principaux domaines techniques abordes sont les suivants: - Neutronique (masses critiques, taux de regeneration, enrichissements, aplatissement du flux de neutrons, coefficients de reactivite, evolution de la reactivite en fonction de l'irradiation), - Dynamique, controle et surete, - Combustible, - Technologie (conception du bloc-pile, des circuits de sodium, des dispositifs pour la manutention des assemblages). Ces etudes techniques se completent de considerations economiques. Le choix de caracteristiques optimales est lie a l'existence de programmes de production d'electricite et, dans ces programmes, a celle des reacteurs a neutrons thermiques producteurs de plutonium. On montre comment il y a lieu de tenir compte de l'existence du plutonium dans ce contexte, et quels sont les mecanismes qui rattachent l'economie de ce plutonium au choix des parametres essentiels des reacteurs surgenerateurs. 4 - Reacteur prototype: On justifie l'interet d'une etape
A fly-wheel drive with controlled-torque clutch for a reactors cooling circuit pumps; Entrainement des pompes du circuit de refrigeration d'un reacteur par volant a embrayage sous couple controle

Energy Technology Data Exchange (ETDEWEB)

Riettini, A [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1964-10-15

After a theoretical study on the slowing down of a centrifugal pump, the motion equations have been checked by means of experimental tests. In order to have important slowing down times (which is the case of the cooling pumps of a research reactor) it is necessary to add a fly-wheel. To prevent troubles when starting, a block pump-fly-wheel with clutch under controlled torque was developed. It is so possible to start the fly-wheel progressively without increasing too much power of the driving motor. (author) [French] Apres une etude theorique sur le mouvement de ralentissement d'une pompe centrifuge, les equations du mouvement ont ete verifiees par des essais pratiques. Pour obtenir des temps de ralentissement importants (cas des pompes de refrigeration d'un reacteur de recherche) il est necessaire d'y adjoindre un volant d'inertie. Pour eviter les inconvenients au demarrage, on a etudie un ensemble pompe-volant avec embrayage sous couple controle. Cette solution permet de lancer progressivement le volant sans augmentation appreciable de la puissance du moteur d'entrainement. (auteur)
Technique of nuclear reactors controls; Technique des controles des reacteurs nucleaires

Energy Technology Data Exchange (ETDEWEB)

Weill, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1953-12-15

This report deal about 'Techniques of control of the nuclear reactors' in the goal to achieve the control of natural uranium reactors and especially the one of Saclay. This work is mainly about the measurement into nuclear parameters and go further in the measurement of thermodynamic variables,etc... putting in relief the new features required on behalf of the detectors because of their use in the thermal neutrons flux. In the domain of nuclear measurement, we indicate the realizations and the results obtained with thermal neutron detectors and for the measurement of ionizations currents. We also treat the technical problem of the start-up of a reactor and of the reactivity measurement. We give the necessary details for the comprehension of all essential diagrams and plans put on, in particular, for the reactor of Saclay. (author) [French] Nous avons aborde le probleme de la ''Technique du Controle des reacteurs nucleaires'' dans le but de realiser le controle du reacteur de Saclay. C'est ainsi que nous avons ete amene a etudier le probleme dans son ensemble, tel qu'il se pose pour tout reacteur a uranium naturel. Ce travail traite principalement du domaine des mesures a caractere nucleaire et s'etend dans le domaine des mesures thermodynamque de niveaux, etc... mettant en relief les caracteristiques nouvelles exigees de la part des detecteurs du fait de leur utilisation dans le flux de neutrons thermiques. Dans le domaine de mesures nucleaires, nous indiquons principalement les realisations et les resultats obtenus pour les detecteurs de neutrons thermiques et pour la mesure de courants d'ionisations. Nous traitons egalement du probleme technique du demarrage d'un reacteur et du probleme de la mesure de la reactivite. Nous donnons les details necessaires a la comrehension de tous les schemas et plans de cablages essentiels mis au point, en particulier, pour le reacteur de Saclay. (auteur)
Burst slug detection system in french power reactors (1961); La detection des ruptures de gaines dans les reacteurs de puissance francais (1961)

Energy Technology Data Exchange (ETDEWEB)

Megy, J; Roguin, A [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1961-07-01

Gas samples are taken from the channels of the reactor and the short lived fission products are electrostatically collected to be analysed by a phosphor and photomultiplier system. The electrostatic collection and rotating electrode detector is described and its main uses exposed. Experience has shown the interest of measuring the evolution of fission products activities and not their absolute value only. In this way, data processing equipment have been designed and adapted to the detection apparatus. The system developed and realized for the G-l - G-2 - G-3 - EDF-1 - EDF-2 reactors are compared. (authors) [French] Un prelevement de gaz est effectue dans les canaux du reacteur et les produits de fission a vie courte sont collectes electrostatiquement pour etre analyses par un ensemble scintillateur-photomultiplicateur. Le detecteur a collection electrostatique et electrode tournante est decrit et ses applications principales sont exposees. L'experience a montre l'interet de mesurer l'evolution des activites en produits de fission et non seulement leur valeur absolue. D'ou le developpement d'ensembles de traitement des informations associes aux chaines de detection. Comparaison des realisations sur les reacteurs G-l - G-2 - G-3 - EDF-1 et EDF-2. (auteurs)
Study of a Slightly Enriched R Reactor Fuel by Means of a Pulsed Neutron Source; Etude d'un reacteur a combustible legerement enrichi (rubeole) a l'aide de sources pulsees de neutrons

Energy Technology Data Exchange (ETDEWEB)

Sagot, M.; Tellier, H. [Commissariat a l' Energie Atomique. Centre d' Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette (France)

1962-04-01

A Be O moderated reactor using slightly enriched uranium oxide as fuel was studied by the pulsed neutron source technique. The neutron lifetime was measured in two different cores without reflector, then attempts were made at the measurement of great negative reactivities introduced into the reactor under the following forms: decrease of the volume of the un reflected core, introduction of absorbing cadmium rods, removal of fuel at the periphery of the critical core while maintaining a constant height, and substitution of fuel elements by less reactive elements. In all cases, the results are compared with the data obtained by another type of experiment or by computation. (author) [French] Nous avons applique la methode des sources pulsees de neutrons a un reacteur utilisant de l'oxyde d'uranium legerement enrichi, modere a l'oxyde de beryllium et, apres avoir mesure le temps de vie des neutrons dans deux coeurs differents non reflechis, nous avons porte notre effort, sur la mesure de reactivites negatives importantes introduites dans le reacteur sous differentes formes: - diminution du volume du coeur non reflechi, - introduction de barres absorbantes en cadmium, - enlevement de combustible a la peripherie du coeur critique, tout en conservant une hauteur constante, - substitution d'elements de combustible par des elements moins reactifs. Dans tous les cas, les resultats sont compares aux valeurs obtenues par un autre type d'experience ou par le calcul. (auteur)
[Project for] a high-flux extracted neutron beam reactor [for physicists]; Un [projet de] reacteur a haut flux et faisceaux sortis [pour physiciens

Energy Technology Data Exchange (ETDEWEB)

Ageron, P [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1964-07-01

tubes and the experimental equipment which can support doses much higher than the ones which are biologically permissible. The final part of the communication describes the studies carried out on the realization of a liquid hydrogen cold sink, one of the most important experimental devices envisaged. (authors) [French] Les besoins francais en canaux pour sortie de neutrons de differentes energies sont brievement indiques. L'interet bien connu des neutrons froids (plus de 4 Angstroem) est souligne. Les grandes lignes d'un reacteur permettant de satisfaire les physiciens sont esquissees. Ce sont les suivantes: 1 - Flux dans l'eau lourde du reflecteur de l'ordre de 7. 10{sup 14} thermiques. 2 - Souplesse d'emploi maximum obtenue par: - separation physique du coeur et du reflecteur, - independance des experiences entre elles, - possibilite de modification, sans interruption notable du fonctionnement de la pile, des experiences physiques jusqu'a - et y compris - la nature du reflecteur utilise, - reduction au minimum des protections fixes; emploi largement generalise des protections liquides (eau) et fluidisees (sables). 3 - Continuite technologique aussi grande que possible avec les reacteurs de recherche francais existant ou en construction (SILOE, PEGASE, OSIRIS). 4 - Surete de fonctionnement recherche par la simplicite de conception. 5 - Minimisation des frais de construction. La reduction des frais d'exploitation est recherchee plutot indirectement par la simplicite des solutions et la reduction du personnel d'exploitation, que directement par la minimisation des consommations d'elements combustibles et d'energie. La solution preconisee peut etre decrite comme un reacteur de type piscine a coeur clos, non pressurise, tres sous modere par l'eau legere de refroidissement. Entourant le reacteur, se trouvent un certain nombre de 'canaux boucles' comprenant chacun: - une portion du reflecteur (eau lourde dans l'exemple decrit), - une portion de canal d'extraction de neutrons
Experimental methods of reactor physics; Methodes experimentales de physique des reacteurs a neutrons thermiques

Energy Technology Data Exchange (ETDEWEB)

Breton, D; Lafore, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

This paper is a synthesis of various experimental methods in use with the reactors of the Commissariat a l'Energie Atomique. The main techniques used are mentioned and the difficulties encountered and the accuracy obtained are particularly dwelt upon. The application of these various methods to reactors in order to obtain specific results is also indicated. This paper consists of five parts. I - General methods. Macroscopic and microscopic flux distribution (anisotropy effect), power distribution, etc... II - Kinetic measurements a) pulsed neutron technique: apparatus and accuracy; application to {lambda}t and to anti reactivity measurements; application to graphite, light water and beryllium oxide. b) oscillation techniques: equipment and accuracy; application to the measurements of effective cross sections and resonance integrals. c) fluctuations: apparatus and technique of measurement. III - Poison methods. Description of methods for introducing and extracting the poison, difficulties encountered with light and heavy water, measurement of temperature coefficients and anti-reactivity. IV - Spectra measurements. Choice and development of foils, problems of measurement, application to spectral measurements for thermalization studies, application to dosimetry. V - Experimental shielding measurements. The technique and apparatus recently developed in this field are presented. (authors) [French] Cette communication fait une synthese des differentes methodes experimentales mises en oeuvre sur les reacteurs du CEA. Elle presente les principales techniques utilisees et insiste plus particulierement sur les difficultes rencontrees et la precision obtenue; elle indique egalement l'application de ces differentes methodes sur les reacteurs, en vue de l'obtention des resultats determines. Elle comporte cinq parties: I - METHODES GENERALES: Distribution de flux macroscopique et microscopique (effet d'anisotropie), distribution de puissance, etc... II - MESURES CINETIQUES: a
Construction of the core of the 'heavy water-gas' reactor EL 4; Structures du coeur du reacteur 'eau- lourde-gaz EL 4'

Energy Technology Data Exchange (ETDEWEB)

Bernard, J L; Foulquier, H; Thome, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

problem of thermal insulation around a zirconium alloy liner tube. The neutron absorption equivalent is about 1, 1 mm of Al, and the mean loss around 2 p. 100 of the thermal power of the reactor. The methods proposed have proved practicable as a result of important research and developments on automatic remote control for all the operations which make up the sequences of mounting, demounting and repairing of the construction components. In particular the possibilities opened up by the new techniques of welding tubes from the inside have been extended to other problems connected with the assembling of a reactor. (authors) [French] Le coeur de ce reacteur est constitue par une cuve contenant l'eau lourde, cuve traversee d'une serie de tubes de force dans lesquels circule le gaz caloporteur sous pression de 60 at. Les specifications de depart qui ont joue un role important dans la conception de ces structures concernent des aspects de securite de fonctionnement (chargement du combustible par les deux faces du reacteur, remplacement des structures sur les deux faces du reacteur), des necessites neutroniques (absorption des structures minimum, pas du reseau, diametre des tubes de force) et des considerations thermiques (temperature de sortie 500 C). Ces specifications ont entraine une disposition horizontale des tubes de force et des problemes d'encombrement tres delicats qui ont elimine (pour les dimensions d'EL 4) toute possibilite de recourir a des compensateurs de dilatation sur les tubes de force. II s'ensuit un dessin de cuve semi-rigide dans lequel les tubes de force contribuent pour une part importante a la resistance mecanique de l'ensemble en jouant le role de tirant, d'ou des contraintes elevees sur les jonctions et tubes de force (et le choix des alliages de zirconium). Les structures comprennent le tube de force, les jonctions, l'isolement thermique et le tube de guidage. On expose brievement les moyens d'essais mis en oeuvre et les performances de ces diverses
Natural uranium-graphite system. Critial experiments on the G1 reactor; Systeme uranium naturel-graphite. Experiences critiques sur le reacteur G1

Energy Technology Data Exchange (ETDEWEB)

Schmitt, A P; Tanguy, P; Teste du Bailler, A; Zaleski, C P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1958-07-01

A number of experiments have been performed during the start up period of the G1 (1956) and G2 (1958) reactors in Marcoule, both on their lattices and on different lattices (hollow rods, clusters, under moderated lattices). The first chapter gives a thorough description of the two reactors. The second chapter deals with buckling measurements, both absolute (flux plots) and relative by the method of progressive substitution. The experimental results are summarised in Table VI. The third chapter contains a number of other measurements performed on G1. (author)Fren. [French] Le demarrage des reacteurs G1 (1956) et G2 (1958) de Marcoule nous a permis d'effectuer une serie d'experiences tant sur les reseaux de ces piles que sur des reseaux differents (elements tubulaires ou divises, reseaux sous-moderes, etc...). Dans une premiere partie, nous donnons une description detaillee des deux reacteurs. Dans la deuxieme partie, relative aux mesures de laplaciens, nous decrivons d'abord les mesures absolues de laplaciens (cartes de flux), puis les mesures relatives effectuees par la methode originale de remplacement progressif. Les resultats experimentaux sont rassembles dans le tableau VI. Dans la troisieme partie, nous rappelons un certain nombre d'autres mesures effectuees sur G1. (auteur)

Molten salts in nuclear reactors; Les sels fondus dans les reacteurs nucleaires

Energy Technology Data Exchange (ETDEWEB)

Dirian, J; Saint-James, [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

1959-07-01

Collection of references dealing with the physicochemical studies of fused salts, in particular the alkali and alkali earth halides. Numerous binary, ternary and quaternary systems of these halides with those of uranium and thorium are examined, and the physical properties, density, viscosity, vapour pressure etc... going from the halides to the mixtures are also considered. References relating to the corrosion of materials by these salts are included and the treatment of the salts with a view to recuperation after irradiation in a nuclear reactor is discussed. (author) [French] Bibliographie regroupant l'etude physico-chimique des sels fondus, en particulier des halogenures alcalins et alcalino-terreux. On etudie de nombreux systemes binaires, ternaires et quaternaires de ces halogenures avec des halogenures d'uranium, et de thorium. On etudie egalement les proprietes physiques des halogenures ou des melanges d'halogenures (densite, viscosite, tension de vapeur, etc...). On donne egalement des references quant a la corrosion des materiaux par ces sels, et le traitement de ceux-ci en vue de recuperation, apres irradiation dans un reacteur nucleaire. (auteur)
The experimental nuclear reactor: AQUILON; Le reacteur nucleaire experimental: AQUILON

Energy Technology Data Exchange (ETDEWEB)

Girard, Y; Koechlin, J C; Moreau, J M [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1958-07-01

'Aquilon' is an experimental reactor specially designed for the neutronic study of heterogeneous multiplying media with solid fuel and liquid moderator. Since this study is in general incompatible with energy production, the power of the reactor has been limited to a minimum so as to be able to obtain a simple and compact structure, easy access, good handling and great flexibility of operation and utilisation. (author) [French] 'Aquilon' est un reacteur experimental specialement concu pour l'etude neutronique de milieux multiplicateurs heterogenes a combustible solide et ralentisseur liquide. Cette etude etant en general incompatible avec la production d'energie, on a limite au minimum la puissance du reacteur pour pouvoir obtenir une structure simple et peu encombrante, un acces facile, une bonne maniabilite et une grande souplesse de fonctionnement et d'utilisation. (auteur)
Contribution to the study on the flow rate adjustment for gas cooled power reactors (1964); Contributiom a l'etude de reglage du debit pour les reacteurs industriels refroidis par gaz (1964)

Energy Technology Data Exchange (ETDEWEB)

Milliot, B [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

1961-06-15

1. This original study firstly defines the problem of the adjustment of the coolant flow rate in a reactor channel as a function of the corresponding heat transfer equations and of the local and temporal neutron flux. The necessity of such an adjustment is pointed out and the modifying parameters are studied. An adjustment study using the envelope of the possible flux curves is developed. A short study on the technology and the economical advantage of this adjustment is presented. Some measurements, made on G-1 and G-2, show the precision one can obtain from adjustment apparatus itself as well as from the complete reactor adjustment system. 2. Evolution of nuclear properties of fuel in an heterogeneous thermal reactor. In the first port of this paper, the phenomena of fuel evolution have been mainly pointed out. Now a bibliographical study more qualitatively than quantitatively has been done. This survey specifies the present theories and relates to a real effective cross section and also yields to the bases of such a nuclear calculation. (author) [French] 1. Cette etude originale definit d'abord le probleme du reglage du debit de refrigerant dans un canal de reacteur en fonction de la formulation du calcul des performances thermodynamiques de ce canal et des variations du flux neutronique dans l'espace et le temps. La necessite du reglage est ensuite mise en evidence et les parametres le modifiant sont etudies. Une methode de reglage, basee sur l'emploi d 'une courbe enveloppe des courbes de flux possibles, est donnee. Une breve etude de la technologie et des incidences economiques du reglage est presentee. Des mesures effectuees sur les reacteurs G-1 et G-2 montrent la precision que l'on peut attendre des dispositifs de reglage comme du reglage d'ensemble du reacteur lui-meme. 2. Evolution des proprietes nucleaires du combustible dans un reacteur heterogene a neutrons thermiques. Les phenomenes d'evolution du combustible tiennent une place importante dans l
Handbook for the calculation of reactor protections; Formulaire sur le calcul de la protection des reacteurs

Energy Technology Data Exchange (ETDEWEB)

NONE

1963-07-01

This note constitutes the first edition of a Handbook for the calculation of reactor protections. This handbook makes it possible to calculate simply the different neutron and gamma fluxes and consequently, to fix the minimum quantities of materials necessary under general safety conditions both for the personnel and for the installations. It contains a certain amount of nuclear data, calculation methods, and constants corresponding to the present state of our knowledge. (authors) [French] Cette note constitue la premiere edition du 'Formulaire sur le calcul de la protection des reacteurs'. Ce formulaire permet de calculer de facon simple les difterents flux de neutrons et de gamma et, par suite, de fixer les quantites minima de materiaux a utiliser pour que les conditions generales de securite soient respectees, tant pour le personnel que pour les installations. Il contient un certain nombre de donnees nucleaires, de methodes de calcul et de constantes correspondant a l'etat actuel de nos connaissances. (auteurs)
Storage of plugs and experimental devices from reactors; Stockage des bouchons et dispositifs experimentaux en provenance des reacteurs (1961)

Energy Technology Data Exchange (ETDEWEB)

Cerre, P; Mestre, E [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1961-07-01

- Within the general programme of storage and treatment of radioactive waste produced by the various operations carried out in an atomic center, it is useful to consider separately the problem of certain waste from reactors, which, because of its size and physical nature, has to be stored with a view to being later treated and finally evacuated. The solution which we propose for this storage problem is presented in this paper. (authors) [French] - Dans le cadre du stockage et du conditionnement des dechets radioactifs provenant des diverses manipulations effectuees dans un centre atomique, il y a lieu de considerer a part certains dechets des reacteurs qui, par leur dimension et leur nature physique doivent etre stockes en vue de leur reprise ulterieure pour un conditionnement et une evacuation definitifs. La solution que nous avons apportee a ce stockage fait l'objet de l'expose qui suit. (auteurs)
Preliminary studies leading to a conceptual design of a 1000 MWe fast neutron reactor; Etudes preliminaires conduisant a un concept de reacteur a neutrons rapides de 1000 MWe

Energy Technology Data Exchange (ETDEWEB)

Vendryes, G.; Zaleski, C.P. [Association Euratom-CEA Cadarache (France). Centre d' Etudes Nucleaires

1964-07-01

This report presents the results of studies which seemed important to undertake in connexion with the development of fast neutron reactors. - It points out the advantage of high internal breeding ratios ({approx}1, 1) which are necessary in order to get a small change in time both in power distribution and reactivity (less: than 0.005 {delta}k/k in 18 months). - It shows how to achieve this goal, when simultaneously power distribution flattening is obtained. These results in a higher mean specific power (which is an economic gain) and therefore in a smaller doubling time (about 10 years). - It attempts to find criteria concerning the specific power that should be used in future reactor designs -It presents a conceptional design of a 1000 MWe fast neutron reactor, for the realisation of which no technological impossibility appears. - It shows that the dynamic behaviour seems satisfactory despite a positive total isothermal sodium coefficient. - It tries to predict the development of fast reactors within the future total nuclear program. It does not appear that fissile materials supply problems should in France slow down the development of fast neutron reactors, which will be essentially tied up to its economical ability to produce cheap electric power. (authors) [French] Ce rapport presente les etudes qu'il nous a paru important d'aborder dans le cadre du developpement des reacteurs a neutrons rapides. - Il met en evidence l'interet des taux de regeneration internes eleves ({approx}1, 1) pour obtenir une bonne evolution dans le temps de la distribution de puissance et de la reactivite (moins de 0,005 {delta}k/k pour 18 mois). - Il montre la possibilite d'y parvenir tout en applatissant la distribution des fissions, ce qui se traduit par une puissance specifique moyenne plus elevee (gain economique), et donc un temps de doublement plus faible de l'ordte de 10 ans - Il tente de definir un optimum de la puissance specifique valable pour les
Preliminary studies leading to a conceptual design of a 1000 MWe fast neutron reactor; Etudes preliminaires conduisant a un concept de reacteur a neutrons rapides de 1000 MWe

Energy Technology Data Exchange (ETDEWEB)

Vendryes, G; Zaleski, C P [Association Euratom-CEA Cadarache (France). Centre d' Etudes Nucleaires

1964-07-01

This report presents the results of studies which seemed important to undertake in connexion with the development of fast neutron reactors. - It points out the advantage of high internal breeding ratios ({approx}1, 1) which are necessary in order to get a small change in time both in power distribution and reactivity (less: than 0.005 {delta}k/k in 18 months). - It shows how to achieve this goal, when simultaneously power distribution flattening is obtained. These results in a higher mean specific power (which is an economic gain) and therefore in a smaller doubling time (about 10 years). - It attempts to find criteria concerning the specific power that should be used in future reactor designs -It presents a conceptional design of a 1000 MWe fast neutron reactor, for the realisation of which no technological impossibility appears. - It shows that the dynamic behaviour seems satisfactory despite a positive total isothermal sodium coefficient. - It tries to predict the development of fast reactors within the future total nuclear program. It does not appear that fissile materials supply problems should in France slow down the development of fast neutron reactors, which will be essentially tied up to its economical ability to produce cheap electric power. (authors) [French] Ce rapport presente les etudes qu'il nous a paru important d'aborder dans le cadre du developpement des reacteurs a neutrons rapides. - Il met en evidence l'interet des taux de regeneration internes eleves ({approx}1, 1) pour obtenir une bonne evolution dans le temps de la distribution de puissance et de la reactivite (moins de 0,005 {delta}k/k pour 18 mois). - Il montre la possibilite d'y parvenir tout en applatissant la distribution des fissions, ce qui se traduit par une puissance specifique moyenne plus elevee (gain economique), et donc un temps de doublement plus faible de l'ordte de 10 ans - Il tente de definir un optimum de la puissance specifique valable pour les projets de reacteurs futurs
Some particular aspects of control in nuclear power reactors; Conception de la surete en france et influence des imperatifs de surete sur la conception des reacteurs

Energy Technology Data Exchange (ETDEWEB)

Vathaire, F de; Vernier, Ph; Pascouet, A [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

This paper reviews the experience acquired in France on the question, of reactor safety. Since a special paper is being presented on reactors of the graphite gas type, the safety of the other types studied in France is discussed here: - heavy water-gas reactors, - fast neutron reactors, - water research reactors of the swimming-pool and tank types. The safety rules peculiar to the different types are explained, with emphasis on their influence on the reactor designs and on the power limits they impose. The corresponding safety studies are presented, particular stress being placed on the original work developed in these fields. Special mention is made of the experimental systems constructed for these studies: the reactor CABRI, pile loop for depressurization tests, loops outside the pile, mock-ups etc. (authors) [French] La presente communication propose une synthese de l'experience acquise en France en matiere de surete des reacteurs. Les reacteurs de la filiere graphite-gaz faisant l'objet d'une communication particuliere, on examine ici la surete des autres types de reacteurs etudies en France: - reacteurs eau lourde-gaz, - reacteurs a neutrons rapides, - reacteurs de recherche a eau des types piscines et tank. Les imperatifs de surete propres aux differentes filieres sont developpes, en mettant l'accent sur leur influence sur la conception des reacteurs et sur les limitations de puissance qu'ils entrainent. Les etudes de surete correspondantes sont presentees, en insistant plus particulierement sur les travaux originaux developpes dans ces domaines. On indique notamment les moyens d'essais qui ont ete construits pour ces etudes: le reacteur CABRI, boucle en pile pour essais de depressurisation, boucles hors pile, maquettes, etc. (auteurs)
Contribution to the study on the flow rate adjustment for gas cooled power reactors (1964); Contributiom a l'etude de reglage du debit pour les reacteurs industriels refroidis par gaz (1964)

Energy Technology Data Exchange (ETDEWEB)

Milliot, B. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

1961-06-15

1. This original study firstly defines the problem of the adjustment of the coolant flow rate in a reactor channel as a function of the corresponding heat transfer equations and of the local and temporal neutron flux. The necessity of such an adjustment is pointed out and the modifying parameters are studied. An adjustment study using the envelope of the possible flux curves is developed. A short study on the technology and the economical advantage of this adjustment is presented. Some measurements, made on G-1 and G-2, show the precision one can obtain from adjustment apparatus itself as well as from the complete reactor adjustment system. 2. Evolution of nuclear properties of fuel in an heterogeneous thermal reactor. In the first port of this paper, the phenomena of fuel evolution have been mainly pointed out. Now a bibliographical study more qualitatively than quantitatively has been done. This survey specifies the present theories and relates to a real effective cross section and also yields to the bases of such a nuclear calculation. (author) [French] 1. Cette etude originale definit d'abord le probleme du reglage du debit de refrigerant dans un canal de reacteur en fonction de la formulation du calcul des performances thermodynamiques de ce canal et des variations du flux neutronique dans l'espace et le temps. La necessite du reglage est ensuite mise en evidence et les parametres le modifiant sont etudies. Une methode de reglage, basee sur l'emploi d 'une courbe enveloppe des courbes de flux possibles, est donnee. Une breve etude de la technologie et des incidences economiques du reglage est presentee. Des mesures effectuees sur les reacteurs G-1 et G-2 montrent la precision que l'on peut attendre des dispositifs de reglage comme du reglage d'ensemble du reacteur lui-meme. 2. Evolution des proprietes nucleaires du combustible dans un reacteur heterogene a neutrons thermiques. Les phenomenes d'evolution du combustible
Measurements of reactivity of reactor G1; Mesures de reactivite sur reacteur G1

Energy Technology Data Exchange (ETDEWEB)

Bernot, J; Koechlin, J C; Portes, L; Teste du Bailler, A [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1957-07-01

The various methods used during the physical study of the reactor G1 to determine the variations of the effective multiplication factor consecutive to a given change in the geometry of the multiplying medium, are presented and discussed. The comparison of the results obtained by these various methods has allowed their validity to be tested and precise conditions of use to be given. In the first part are presented the principles used and their ranges of validity. In the second part the experimental results are given, together with some indications on their comparison with theoretical estimations. (author) [French] Nous exposons et discutons diverses methodes utilisees, lors de l'etude physique du reacteur G1, pour determiner les variations du facteur de multiplication effectif consecutives a un changement donne dans la geometrie du milieu multiplicateur. La comparaison des resultats obtenus par diverses methodes nous a permis de tester leur validite et d'en preciser les conditions d'emploi. Dans une premiere partie, nous exposons les principes utilises et leurs domaines de validite. Dans une seconde partie nous donnons les resultats experimentaux obtenus avec quelques indications sur leur comparaison avec les estimations theoriques. (auteur)
Contribution to the study and use of ionisation chambers for nuclear reactor control (1965); Contribution a l'etude et a l'utilisation des chambres d'ionisation pour le controle des reacteurs nucleaires (1965)

Energy Technology Data Exchange (ETDEWEB)

Duchene, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1961-02-15

high-power reactors. (author) [French] Les chambres d'ionisation sont actuellement les detecteurs les mieux adaptes au controle des reacteurs nucleaires par des mesures neutroniques. Nous avons cru bon de rappeler quelques generalites concernant la dynamique des reacteurs, les differents procedes de detection des neutrons, le fonctionnement des chambres d'ionisation et les methodes de mesure utilisees. Notre contribution aux techniques de controle des reacteurs consiste d'une part en une tentative de synthese des facteurs intervenant dans le fonctionnement des chambres d'ionisation, l'etude de ces facteurs, et d'autre part l'elaboration de chambres d'ionisation a fission et a bore permettant de suivre la marche d'un reacteur du demarrage jusqu'a la puissance maximale. Dans le domaine des chambres a fission, nous avons en particulier ameliore les techniques de depot d'oxyde d'uranium sur l'aluminium et realise la mise au point de depots par electrolyse sur d'autres metaux: acier inoxydable, cuivre, molybdene, nickel, tantale, titane, kovar, tungstene et beryllium. Nous avons elabore plusieurs types de chambres a fission servant au demarrage des reacteurs: un type de performances moyennes actuellement utilise dans les piles francaises un type a haute sensibilite un type a haute temperature qui a fonctionne jusqu'a 600 deg. C. En ce qui concerne les chambres a bore, nous avons etudie les perturbations apportees dans les mesures par l'exposition des chambres a d'importants flux de neutrons et a un rayonnement {gamma} intense. Cette exposition produit une modification des proprietes des materiaux constitutifs et la production dans les chambres d'un bruit de fond qui peut gener considerablement les mesures neutroniques. Nous avons montre que la technique de compensation permettait de limiter l'importance de ce bruit de fond et d'augmenter ainsi la plage de fonctionnement des chambres d'ionisation classiques destinees aux mesures de puissance. Enfin, nous avons realise deux
Installation for Studying the Scattering of Cold Neutrons; Installation pour l'etude de la diffusion des neutrons thermiques; Ustanovka dlya izucheniya rasseyaniya kholodnykh nejtronov; Instalacion para estudiar la dispersion de neutrones frios

Energy Technology Data Exchange (ETDEWEB)

Golikov, V V; Shapiro, F L; Shkatula, A; Yanik, E A [Ob' edinennyj institut yadernykh issledovanij, Dubna, Union of Soviet Socialist Republics (Russian Federation)

1963-01-15

Using the pulsed fut reactor in the Joint Institute for Nuclear Research, an installation was set up to investigate the spectrometry of cold neutrons. The moderator, adjoining the reactor reflector, and the beryllium filter were at the temperature of liquid nitrogen. The scatterer, located at a distance of about 0. 6 m from the moderator, was irradiated by flashes of cold neutrons, whose duration was determined by the lifetime of the neutrons in the moderator and the dispersion of the times-of-flight over a distance of 0. 6 m. The frequency of the flashes was 8/s. The steep beryllium edge of the spectrum, lying around 200 {mu}s, was used for spectrometry in the quasi-elastic range. The energy of the scattered neutrons was determined by the time-of-flight over the distance between scatterer and detector, which was about 10-40 m. ZnS + 10{sub 2}{sup 10} O{sub 3} scintillation detectors with surfaces of 300 and 2 000 cm{sup 2} were used and the efficiency, for fast neutrons, was about 60%. (author) [French] A l'aide du reacteur a flux pulse de neutrons rapides de l'Institut unifie de recherches nucleaires, les auteurs ont mis au point une installation pour la spectrometrie des neutrons thermiques. Le ralentisseur contigu au reflecteur du reacteur et le filtre deberyllium sont maintenus a la temperature de l'azote liquide. Le diffuseur, place a environ 60 cm du ralentisseur, est irradie par une bouffee de neutrons thermiques dont la duree est determinee par la vie moyenne des neutrons dans le ralentisseur et par l'etalement des temps de vol necessaires pour parcourir la distance de 60 cm. La frequence des bouffees est de 8/s. Pour la spectrometrie dans la region quasi-elastique, on utilise la bande en bordure du spectre qui correspond au beryllium et s'etale sur environ 200 {mu}s. L'energie des neutrons diffuses est determinee par la duree du parcours entre le diffuseur et le detecteur. Les auteurs ont utilise des detecteurs a scintillation a ZnS + 10{sub 2}{sup 10} O
The fast breeder reactor Rapsodie (1962); Le reacteur rapide surregenerateur rapsodie (1962)

Energy Technology Data Exchange (ETDEWEB)

Vautrey, L; Zaleski, C P [Commissariat a l' Energie Atomique, Cadarache (France). Centre d' Etudes Nucleaires

1962-07-01

In this report, the authors describe the Rapsodie project, the French fast breeder reactor, as it stands at construction actual start-up. The paper provides informations about: the principal neutronic and thermal characteristics, the reactor and its cooling circuits, the main handling devices of radioactive or contaminated assemblies, the principles and means governing reactor operation, the purposes and locations of miscellaneous buildings. Rapsodie is expected to be critical by 1964. (authors) [French] Dans ce rapport, les auteurs font le point du projet RAPSODIE (reacteur francais surregenerateur a neutrons rapides), au moment du debut effectif de sa construction. On y trouvera decrits: les principales caracteristiques neutroniques et thermiques, le bloc pile et les circuits de refroidissement, les principaux moyens de manutention des ensembles actifs ou contamines, les principes et les moyens qui regissent la conduite du reacteur, les fonctions et l'implantation des divers batiments. La divergence de RAPSODIE est prevue pour 1964. (auteurs)
Dynamic problems of power reactors and analogic devices; Les problemes dynamiques du reacteur de puissance et les machines analogiques

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Braffort, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1955-07-01

The raise of the nuclear physics came with heavy mathematical developments. The analogical installations became especially useful for precise calculations of parameters which depend the running of a reactor. They permit between other to study of kinetic problems and especially ''cybernetics'' of nuclear reactors. It doesn't make a doubt that their use will become widespread, not only in the calculations laboratories, in services for servo-mechanisms study, but also in the control panels of the reactors themselves. (M.B.) [French] L'essor de la physique nucleaire s'est accompagne de lourds developpements mathematiques. Les montages analogiques sont devenus particulierement utiles pour les calculs precis des parametres dont depend le fonctionnement d'un reacteur. Elles permettent entre autre l'etude des problemes cinetiques et surtout ''cybernetiques'' des reacteurs nucleaires. Il ne fait pas de doute que leur usage se generalisera, non seulement dans les laboratoires de calculs, les services d'etudes de servomecanismes, mais aussi pres des tableaux de commande des reacteurs eux-memes. (M.B.)
The functioning of the reactors G2-G3 at Marcoule and E.D.F. 1; Experience de fonctionnement des reacteurs G2-G3 de Marcoule et enseignements des essais de demarrage du reacteur E.D.F. 1 de Chinon

Energy Technology Data Exchange (ETDEWEB)

Boussard, R; Conte, F [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires; Stolz, J M [Electricite de France (EDF), 75 - Paris (France)

1964-07-01

After resuming briefly the characteristics of the installations G2-G3 at Marcoule and EDF 1 at Chinon, the authors review the main aspects of the tests, the starting and the exploitation of these reactors. Among the various points examined, particular emphasis is given to the devices of original nature such as tubular fuel elements, flattening of the neutron flux by stuffing, behaviour of the reactor tanks and the cooling circuits, the blowers, unloading devices, regulation and functioning of the informations. This analysis deals equally with the performances obtained and the difficulties and the various incidents experienced during the initial starting period. Among the more interesting results, the progressive increase in the power of the Marcoule reactors is mentioned, obtained through a better knowledge of the parameters covering the functioning of the reactors such as the distribution of the flux and the temperatures etc... acquired during the course of the exploitation of the reactor. The conclusion reached by the authors is that the experience gained on these installations has shown: - that during an initial period, adjustments became necessary, all of which turned out to be possible, - that an analysis of their functioning has permitted the progressive movement towards a truly industrial exploitation. (authors) [French] Les auteurs, apres un bref rappel des caracteristiques des installations G2 - G3 de MARCOULE et E.D.F. 1 de CHINON, passent en revue les principaux aspects des essais, de la mise en service et de l'exploitation de ces centrales. Parmi les divers points examines, une attention speciale est accordee aux dispositifs presentant un caractere original tels que elements combustibles tubulaires, aplatissement du flux neutronique par gavage, comportement des caissons des reacteurs et des circuits de refroidissement, soufflantes, appareils de dechargement, regulation et fonctionnement des informations. L'analyse presentee porte tant sur les
The CO{sub 2} cooling gas for the reactors G2/G3 (leaking, analysis, activity); Le CO{sub 2} de refroidissement des reacteurs G2/G3 (fuites, analyse, activite)

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Meiffren, J; Dupay, F [Commissariat a l' Energie Atomique, Centre de Production de Plutonium, Marcoule (France). Centre d' Etudes Nucleaires

1965-07-01

The main objective of this study is to publicise the data obtained during five years operation of the reactor G2 and G3 at Marcoule as far as the cooling gas is concerned, from storage of reserves up to its slow escape into the atmosphere, and including all the stages of its practical use, its chemical examination, its nuclear behaviour and its possible physicochemical transformation. This work can not only yield information about the operations carried out at Marcoule but can also provide useful suggestions for improving the sealing and for decreasing the activity of the pressurized gas circuits in reactors similar to G2/G3. (authors) [French] Le but principal de cette etude est de diffuser les connaissances acquises au cours de cinq annees d'exploitation des reacteurs G2 et G3 de Marcoule en ce qui concerne le gaz de refroidissement, depuis son stockage d'appoint jusqu'a son echappement lent dans l'atmosphere, en passant par tous les stades de son utilisation pratique, de son etude chimique, de son comportement nucleaire, eventuellement de ses transformations physico-chimiques. Cette etude peut, non seulement renseigner sur les operations effectuees couramment a Marcoule, mais egalement donner des suggestions interessantes pour l'amelioration de l'etancheite et la diminution de l'activite des circuits de gaz en pression dans des reacteurs analogues a G2/G3. (auteurs)
Study of the chimney produced by an underground nuclear explosion; Etude de la cheminee creee par une explosion nucleaire souterraine

Energy Technology Data Exchange (ETDEWEB)

Derlich, S [Commissariat a l' Energie Atomique, Bruyeres-le-Chatel (France). Centre d' Etudes

1969-07-01

Underground nuclear explosions lead to the formation of a cavity which is roughly of spherical shape. The roof of this cavity is unstable and collapses in most cases, leading to the formation of a chimney. The height and the diameter depend on the energy of the charge and on the nature of the surroundings. The chronology of the various stages can be determined by seismic observations. The interior of the chimney is filled, either partially or completely, with rubble earth. This phenomenon is of great importance as far as the use of nuclear explosions for industrial applications is concerned. (author) [French] Les explosions nucleaires souterraines creent une cavite de forme grossierement spherique. La voute de cette cavite est instable et s'effondre dans la plupart des cas, donnant lieu a la formation d'une cheminee. La hauteur et le diametre sont fonction de l'energie du tir et de la nature du milieu. La chronologie des evenements peut etre determinee par des observations seismiques. L'interieur des cheminees est occupe, en partie ou en totalite, par des eboulis. Ce phenomene presente un grand interet pour l'utilisation des explosions nucleaires a des fins industrielles. (auteur)
Space-time dependent impulse response of a subcritical cylindrical reactor; Reponse impulsionnelle spatio-temporelle d'un reacteur cylindrique en regime sous-critique

Energy Technology Data Exchange (ETDEWEB)

Cazemajou, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1965-07-01

In this paper, a new formulation of the spatial dependent impulse response of a subcritical reactor in a cylindrical geometry is proposed. An expression of the transfer function between a point source at the center of coordinates and the flux at a given point (r,z) is obtained by solving: by means of Laplace transform, the one group diffusion equation. In this transfer function, variables r and p (p being the Laplace variable) remain linked within a modified Bessel function. Taking the inverse Laplace transform is done by two different ways: - using the Mellin-Fourier method which separates variables r and t. This method makes it possible to establish that there is identity between the classical formulation and the new one. - using an inverse Laplace transform which keeps variables r and t linked. This method requires to approximate the inverse Laplace transform of the end factor. It is then possible to replace the radial harmonics modes series of the classical expression by a single function. This new formulation seems to be of particular interest when dealing with reactors of large size and lifetime. It is also interesting each time the harmonics play an important role. (author) [French] Dans le present rapport, on propose une nouvelle formulation de la reponse impulsionnelle spatio-temporelle d'un reacteur sous-critique, en geometrie cylindrique. Une expression de la fonction de transfert entre une source ponctuelle placee au centre des coordonnees et le flux au point courant (r,z) est obtenue en resolvant, par transformation de Laplace, l'equation de la diffusion a un seul groupe d'energie. Dans cette fonction de transfert, les variables r et p (variable de Laplace) demeurent groupees dans une fonction de Bessel modifiee. Le retour a l'original est effectue de deux manieres: - la methode de Mellin-Fourier qui separe les variables r et t, permet d'etablir l'identite entre la nouvelle formulation et la formulation classique. - un original conservant les variables
Some particular problems put by operating experimental reactors; Quelques problemes particuliers poses par le fonctionnement des piles laboratoires

Energy Technology Data Exchange (ETDEWEB)

Candiotti, C; Mabeix, R; Uguen, R [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

1960-07-01

On basis of a six years experience in operating research reactors, the authors explain, first, the difference in their utilization between these piles and another similar ones and, after, in consequence, they set off corresponding servitudes. These servitudes put very particular problems in operating itself, maintenance, modifications or additions on these apparatus. (author) [French] Les redacteurs se basant sur six annees d'experience dans l'exploitation de reacteurs de recherche, exposent tout d'abord les differences d'utilisation entre ces engins et d'autres appareils fonctionnellement similaires et font ressortir, par voie de consequence, les servitudes correspondantes. Ces servitudes posent des problemes tres particuliers dans les domaines de l'exploitation proprement dite, de l'entretien, des modifications ou adjonctions apportees a l'ensemble. (auteur)
Study of the formation and of the distribution of dissolved gases and hydrogen peroxide in water from a swimming-pool reactor (triton) (1961); Etude de la formation et de la repartition des gaz dissous et de l'eau oxygenee dans l'eau d'un reacteur piscine (triton) (1961)

Energy Technology Data Exchange (ETDEWEB)

Chenouard, J; Rozenberg, J; Dolle, L; Dirian, G [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1961-07-01

In order to determine experimentally the amount of radiolysis in the swimming-pool reactor Triton, direct measurements have been made of the quantity of radiolysis gas and hydrogen peroxide in the water, at the entry and exit of the core. The concentration distribution of these gases in the reactor was also determined. An explanation is given as to why no gases evolution is seen in the swimming-pool reactors of the C.E.A. The overall amount of radiolysis is zero, and a simple interpretation of this result is possible. The real amount of radiolysis occurring in the reactor core can be calculated. This is in satisfactory agreement with certain measurement mad elsewhere. (authors) [French] Pour determiner experimentalement le taux de radiolyse dans la pile piscine Triton, des mesures directes de la quantite de gaz de radiolyse et d'eau oxygenee dans l'eau a l'entree et a la sortie du coeur ont ete faites. La repartition de la concentration de ces gaz dans la piscine a egalement ete determinee. On explique pourquoi aucun degagement gazeux n'est observe dans les piles piscines du CE.A. Le taux de radiolyse global est nul, et une interpretation simple de ce resultat est possible. Un taux de radiolyse reel dans le coeur du reacteur peut etre calcule. Celui-ci est en accord satisfaisant avec certaines determinations faites ailleurs. (auteurs)

The physics design of EBR-II; Physique du reacteur EBR-II; Fizicheskij raschet ehksperimental'nogo reaktora - razmnozhitelya EVR-II; Aspectos fisicos del reactor EBR-II

Energy Technology Data Exchange (ETDEWEB)

Loewenstein, W. B. [Argonne National Laboratory, Argonne, IL (United States)

1962-03-15

) [French] L'auteur presente les calculs du comportement d'EBR-II statique, dynamique et sous evolution a long terme de la reactivite ainsi que les resultats et l'analyse des experiences critiques seches faites sur EBR-II et en simulation sur ZPR-III. Il insiste particulieremen t sur les problemes de physique des reacteurs qui, dans l'elaboration du projet, suivent le choix du modele theorique et precedent la construction ou la mise en exploitation. L'auteur presente des analyses de la securite des reacteurs ainsi que diverses considerations sur l'evaluation des risques sous l'angle de leur influence sur le projet de reacteur. Il decrit la simulation d'EBR-II, a partir des renseignements fournis par le ZPR-III ainsi que les mesures critiques seches sur EBR-II. Ces experiences, leur analyse et les previsions des calculs servent de bases pour predire le comportement physique du reacteur. L'auteur approfondit quelque peu la validite intrinseque de l'application des donnees experimentales au fonctionnement du reacteur de puissance. Ceci comprend les donnees precises des dimensions du coeur et/ou de l'enrichissement de l'alliagne combustible, le choix convenable des valeurs de la reactivite prevues en exploitation et pendant l'arret, la determination des coefficients de reactivite a la temperature et a la puissance de fonctionnement, et la distribution precise de la puissance et du flux en fonction de la position dans l'ensemble du reacteur. L'auteur decrit le probleme de l'application des renseignements obtenus a partir d'une geometrie simple, ideale, analytique ou experimentale, a la geometrie reelle hexagonale du reacteur. Il compare le rendement nucleaire, y compris la surgeneration, du reacteur reel par rapport a celui du modele theorique. Il decrit la reactivite a long terme et le comportement energetique de la couche fertile du reacteur dans le cadre de l'etude du cyclage propose du combustible et de l'alliage fertile. L'auteur etudie les questions de securite considerant
The Control of Fast Reactors: Current Methods and Future Prospects; Controle des Reacteurs a Neutrons Rapides. Methodes Actuelles et Perspectives d'Avenir; Upravlenie reaktorami na bystrykh nejtronakh. sushchestvuyushchie metody i dal'nejshie perspektivy; Control de Reactores Rapidos: Metodos Actuales y Perspectivas

Energy Technology Data Exchange (ETDEWEB)

Loewenstein, W. B. [Argonne National Laboratory, IL (United States)

1964-06-15

important dans le choix des materiaux absorbants. L'auteur decrit les modeles actuels de mecanismes de controle d'un reacteur a neutrons rapides. Ceux-ci ont tendance a tirer parti, la ou cela est possible, du principe du controle des fuites de neutrons. La ou il n'est pas possible d'appliquer ce principe, on a frequemment recours au controle par deplacement de matieres du coeur. On a egalement recours dans une certaine mesure au controle par absorbant. Aucune de ces methodes ne presente d'avantages notables lorsqu'elle est appliquee au reacteur surgenerateur d'une centrale, a moins que le rapport de conversion dans le coeur ne soit tres eleve. Il faudra deployer beaucoup d'ingeniosite pour trouver le moyen d'utiliser les methodes de controle par absorbant ou par modification du spectre sans affecter gravement l'economie des neutrons souhaitee et souvent necessaire. L'auteur mentionne les resultats d'etudes portant sur les systemes les plus perfectionnes. La reactivite qu'il faut donner aux barres de controle est determinee par la reactivite necessaire pour l'arret brusque du reacteur, le cycle du combustible (exces de reactivite) et dans une mesure mouns grande, les effets des facteurs dominants. On peut fixer tres exactement l'exces de reactivite pour un cycle de combustible donne, mais cet exces peut varier considerablement pouf des reacteurs similaires, s'ils fonctionnent avec des cycles de combustible differents. On peut, dans certaines limites, fixer presque arbitrairement la reactivite necessaire pour l'arret brusque. Cependant, certaines considerations militent en faveur d'une determination precise de ce parametre. L'auteur examine la question sous tous ces aspects en comparant la reactivite des barres de controle dans les reacteurs a neutrons rapides actuels et la quantite de reactivite dont on a reellement besoin pour le fonctionnement d'un reacteur surgenerateur a neutrons rapides.. P cite les parametres typiques dependant de la puissance et de la temperature
Improvements in gas supply systems for heavy-water moderated reactors; Etudes de perfectionnements aux systemes d'alimentation en gaz d'un reacteur modere a l'eau lourde

Energy Technology Data Exchange (ETDEWEB)

Aubert, G; Hassig, J M; Laurent, N; Thomas, B [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

In a heavy-water moderated reactor cooled by pressurized gas, an important problem from the point of view, of the reactor block and its economics is the choice of the gas supply system. In the pressure tube solution, the whole of the reactor block structure is at a relatively low temperature, whereas the gas supply equipment is at that of the gas, which is much higher. These parts, through which passes the heat carrying fluid have to present as low a resistance as possible to it so as to avoid costly extra blowing power. Finally, they may only be placed in the reactor block after it has been built; the time required for putting them in position should therefore not be too long. The work reported here concerns the various problems arising in the case of each channel being supplied individually by a tube at the entry and the exit which is connected to a main circuit made up of large size collectors. This individual tubing is sufficiently flexible to absorb the differential expansion and the movement of its ends without stresses or prohibitive reactions being produced; the tubing is also of relatively short length so as to reduce the pressure head of the pressurized gas outside the channels; the small amount of space taken up by the tubing makes it possible to assemble it in a manner which is satisfactory from the point of view both of the time required and of the technical quality. (authors) [French] Dans un reacteur modere a l'eau lourde et refroidi au gaz sous pression, un probleme important du point de vue du trace du bloc pile et de son economie est le choix du systeme d'alimentation en gaz. Pour une solution a tubes de force, l'ensemble des structures du bloc reacteur est a temperature relativement faible, alors que les organes d'alimentation en gaz sont a celle, notablement plus elevee, du gaz. Ces organes, traverses par le debit du caloporteur, doivent lui opposer le minimum de resistance afin de ne pas necessiter un supplement onereux de puissance de
Measurement and regulation of the level of a homogeneous plutonium reactor; Mesure et regulation du niveau d'un reacteur homogene au plutonium

Energy Technology Data Exchange (ETDEWEB)

Berger, F; Bertrand, J

1958-12-01

Reactivity depends strongly on disturbances of the level of the plutonium solution In the homogeneous reactor. Proserpine has a small cylindrical core, 250 mm diameter, and 10 liters volume. With a view to reducing the dangers due to corrosion and contamination, the solution level in the core is raised by pneumatic pressure. The level is stabilized by means of a regulating system. During critical experiments the variations of the level are less than one hundredth part of a millimeter. (author) [French] Les variations du niveau de la solution de plutonium dans le reacteur homogene Proserpine ont une grosse influence sur la reactivite, car le coeur est petit (10 litres de solution dans un cylindre de diametre 250 mm). En vue de reduire les dangers dus a la corrosion et a la contamination, la commande du volume liquide est pneumatique. Nous avons realise la stabilite du niveau par une regulation qui, dans les essais en regime critique, limite les variations du plan liquide a une fraction de centieme de millimetre. (auteur)
Study of new structures adapted to gas-graphite and gas-heavy water reactors; Etude de structures nouvelles adaptees aux reacteurs graphite-gaz et eau lourde-gaz

Energy Technology Data Exchange (ETDEWEB)

Martin, R; Roche, R [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

The experience acquired as a result of the operation of the Marcoule reactors and of the construction and start-up of the E.D.F. reactors on the one hand, and the conclusions of research and tests carried out out-of-pile on the other hand, lead to a considerable change in the general design of reactors of the gas-graphite type. The main modifications envisaged are analysed in the paper. The adoption of an annular fuel element and of a down-current cooling will make it possible to increase considerably the specific power and the power output of each channel; as a result there will be a considerable reduction in the number of the channels and a corresponding increase in the size of the unit cell. The graphite stack will have to be adapted to there new conditions. For security reasons, the use of prestressed concrete for the construction of the reactor vessel is becoming more widespread; they could lead to the exchangers and the fuel-handling apparatus becoming integrated inside the vessel (the so-called 'attic' device). A full-size mode) of this attic has been built at Saclay with the participation of EURATOM; the operational results obtained are presented as well as a new original design for the control rods. As for as the gas-heavy-water system is concerned, the research is carried out on two points of design; the first, which retains the use of horizontal pressure tubes, takes into account the experience acquired during the construction of the EL 4 reactor of which it will constitute an extrapolation; the second, arising from the research carried out on the gas-graphite system, will use a pre-stressed concrete vessel for holding the pressure, the moderator being almost at the same pressure as the cooling fluid and the fuel being placed in vertical channels. The relative merits of these two variants are analysed in the present paper. (authors) [French] L'experience acquise par l'exploitation des reacteurs de MARCOULE, la construction et le demarrage des reacteurs d
Some particular problems put by operating experimental reactors; Quelques problemes particuliers poses par le fonctionnement des piles laboratoires

Energy Technology Data Exchange (ETDEWEB)

Candiotti, C.; Mabeix, R.; Uguen, R. [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

1960-07-01

On basis of a six years experience in operating research reactors, the authors explain, first, the difference in their utilization between these piles and another similar ones and, after, in consequence, they set off corresponding servitudes. These servitudes put very particular problems in operating itself, maintenance, modifications or additions on these apparatus. (author) [French] Les redacteurs se basant sur six annees d'experience dans l'exploitation de reacteurs de recherche, exposent tout d'abord les differences d'utilisation entre ces engins et d'autres appareils fonctionnellement similaires et font ressortir, par voie de consequence, les servitudes correspondantes. Ces servitudes posent des problemes tres particuliers dans les domaines de l'exploitation proprement dite, de l'entretien, des modifications ou adjonctions apportees a l'ensemble. (auteur)
General views about specimen irradiations in reactors; Considerations generales sur'les irradiations d'echantillons dans les reacteurs

Energy Technology Data Exchange (ETDEWEB)

Seguin, M [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1965-07-01

Specimen irradiation of fissile or non-fissile materials, carried out under circumstances becoming more and more severe and in reactor of increasing flux bas led to an evolution of irradiation rigs. A survey of the problems arising from irradiating under these various circumstances leads to conclude that it is possible to devise one capsule type suitable to every particular case, and that in a wide temperature range. Consequently, once the various irradiation-parameters known, a general method of calculation can be followed so as to determine the various sizes of the parts constituting the capsule. These theoretical calculations might sometimes be corrected through benefits gained from previous irradiations. Similarly, practical experimentation might allow to foresee more handy assembling of the capsule, specimen loading-and unloading being easier at the same time. (author) [French] L'irradiation d'echantillons, fissiles ou non fissiles, dans des conditions imposees de plus en plus strictes et dans des reacteurs a flux de plus en plus eleve, a eu pour consequence une evolution dans la conception des dispositifs d'irradiation. Lorsqu'on examine les problemes souleves par ces differentes irradiations, on en conclut qu'il est possible de concevoir un type de capsule capable de donner satisfaction dans chaque cas particulier, et ce, dans une tres large gamme de temperature. Par consequent, les differents parametres de l'irradiation etant connus, une methode generale de calcul peut etre suivie pour determiner les differentes cotes des pieces constitutives de la capsule. Ces calculs theoriques devront quelquefois etre corriges grace aux enseignements tires d'irradiations precedentes. De meme, l'experience acquise permettra d'envisager un montage plus aise de la capsule, tout en facilitant l'enfournement et le defournement des echantillons.
New modelling method for fast reactor neutronic behaviours analysis; Nouvelles methodes de modelisation neutronique des reacteurs rapides de quatrieme Generation

Energy Technology Data Exchange (ETDEWEB)

Jacquet, P.

2011-05-23

Due to safety rules running on fourth generation reactors' core development, neutronics simulation tools have to be as accurate as never before. First part of this report enumerates every step of fast reactor's neutronics simulation implemented in current reference code: ECCO. Considering the field of fast reactors that meet criteria of fourth generation, ability of models to describe self-shielding phenomenon, to simulate neutrons leakage in a lattice of fuel assemblies and to produce representative macroscopic sections is evaluated. The second part of this thesis is dedicated to the simulation of fast reactors' core with steel reflector. These require the development of advanced methods of condensation and homogenization. Several methods are proposed and compared on a typical case: the ZONA2B core of MASURCA reactor. (author) [French] Les criteres de surete qui regissent le developpement de coeurs de reacteurs de quatrieme generation implique l'usage d'outils de calcul neutronique performants. Une premiere partie de la these reprend toutes les etapes de modelisation neutronique des reacteurs rapides actuellement d'usage dans le code de reference ECCO. La capacite des modeles a decrire le phenomene d'autoprotection, a representer les fuites neutroniques au niveau d'un reseau d'assemblages combustibles et a generer des sections macroscopiques representatives est appreciee sur le domaine des reacteurs rapides innovants respectant les criteres de quatrieme generation. La deuxieme partie de ce memoire se consacre a la modelisation des coeurs rapides avec reflecteur acier. Ces derniers necessitent le developpement de methodes avancees de condensation et d'homogenisation. Plusieurs methodes sont proposees et confrontees sur un probleme de modelisation typique: le coeur ZONA2B du reacteur maquette MASURCA
Fluctuations in a system depending on several random parameters. Application to reactors (1962); Fluctuations d'un systeme dependant de plusieurs parametres aleatoires. Application aux reacteurs nucleaires (1962)

Energy Technology Data Exchange (ETDEWEB)

Blaquiere, A [Faculte des Sciences de Paris, 75 (France); Pachowska, R [Universite Technique de Varsovie (Poland)

1962-07-01

'un reacteur et celui de certains circuits radioelectriques usuels. Les fluctuations peuvent alors etre calculees par l'introduction dans le circuit d'une source de bruit convenable. Cette methode nous a permis d'aborder sous une forme particulierement simple l'etude des fluctuations d'ensemble et de preciser la signification physique de certains resultats auxquels conduisent plus laborieusement les autres methodes. L'objet du present rapport est de generaliser cette methode,notamment de l'etendre au cas d'un reacteur ayant une structure en cellules et de l'appliquer a l'etude des fluctuations dans une cellule. On etablit ainsi simplement que les fluctuations dans une cellule sont la resultante de deux termes: - un bruit poissonnien a evolution rapide, non correle avec les fluctuations d'ensemble ; - un bruit a evolution lente, lorsque le reacteur n'est pas trop eloigne de la criticalite, correle avec les fluctuations d'ensemble. Le premier terme provient d'une 'mise en ordre' rapide du systeme, au cours de laquelle les cellules se mettent en equilibre entre elles. Le deuxieme terme traduit l'evolution coordonnee de l'ensemble des cellules, apres extinction de la premiere phase transitoire. Les conclusions de l'etude montrent qu'il serait utile de la completer par une analyse des phenomenes non lineaires qui peuvent influer considerablement sur le comportement transitoire des cellules, pendant la phase ou elles tendent a se mettre en equilibre entre elles. Ce rapport met aussi l'accent sur les liens entre la nouvelle methode et les methodes anterieures. De plus, il tend a faire entrer la theorie des fluctuations des piles dans un cadre plus general, celui des fluctuations d'un systeme dependant de plusieurs parametres aleatoires, et de ce point de vue, la methode pourrait etre aisement transposee et adaptee a l'etude d'autres problemes physiques de ce type. (auteurs)
General design and main problems of a gas-heavy-water power reactor contained in a pressure vessel; Conception generale et principaux problemes d'un reacteur de puissance eau lourde-gaz contenu dans un caisson resistant

Energy Technology Data Exchange (ETDEWEB)

Roche, R; Gaudez, J C [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

In the framework of research carried out on a CO{sub 2}-cooled power reactor moderated by heavy water, the so-called 'pressure vessel' solution involves the total integration of the core, of the primary circuit (exchanges and blowers) and of the fuel handling machine inside a single, strong, sealed vessel made of pre-stressed concrete. A vertical design has been chosen: the handling 'attic' is placed above the core, the exchanges being underneath. This solution makes it possible to standardize the type of reactor which is moderated by heavy-water or graphite and cooled by a downward stream of carbon dioxide gas; it has certain advantages and disadvantages with respect to the pressure tube solution and these are considered in detail in this report. Extrapolation presents in particular.problems due specifically to the heavy water (for example its cooling,its purification, the balancing of the pressures of the heavy water and of the gas, the assembling of the internal structures, the height of the attic, etc. (authors) [French] Dans le cadre des etudes d'un reacteur de puissance modere a l'eau lourde et refroidi-au gaz carbonique, la solution dite 'en caisson' consiste en une integration totale du coeur, du circuit primaire (echangeurs et soufflantes) et du dispositif de manutention du combustible a l'interieur d'un meme caisson etanche et resistant en beton precontraint. La disposition envisagee est verticale; le grenier de manutention est dispose au-dessus du coeur, les echangeurs en dessous. Cette solution, qui permet d'uniformiser les types de reacteurs moderes a l'eau lourde ou au graphite et refroidis par une circulation descendante de gaz carbonique presente, par rapport a la solution a tube de force, des avantages et des inconvenients qui sont analyses dans cette etude. L'extrapolation pose, en particulier, des problemes specifiques a l'eau lourde (tels que son refroidissement, son epuration, l'equilibrage des pression entre l'eau lourde et le gaz, le montage
Measurement of the thermal utilisation factor of the reactor G1; Mesure du facteur d'utilisation thermique du reacteur G1

Energy Technology Data Exchange (ETDEWEB)

Roullier, F; Schmitt, A P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1957-07-01

The thermal utilisation factor of the lattice of the reactor G1 has been measured by applying the autoradiographic technique to thin detectors irradiated in the cell. The experimental apparatus is described, and the results compared with those obtained by calculation based on various formulae. The results of the study of the thermal flux distribution in a cell containing a thorium rod of the same diameter as the uranium rods in the lattice are also given. The precision of the measurements is discussed. Value found: f diameter 26 = 0.8949 {+-} 0,005. (author) [French] Le facteur d'utilisation thermique du reseau du reacteur G1 a ete mesure en appliquant la technique de l'autoradiographie a des detecteurs minces irradies dans la cellule. Les dispositifs experimentaux sont decrits et les resultats sont compares a ceux obtenus par le calcul a partir de diverses formules. Les resultats de l'etude de la distribution du flux thermique dans une cellule contenant une barre de thorium de meme diametre que les barres d'uranium du reseau sont egalement indiques. La precision des mesures est discutee. Valeur trouvee: f diametre 26 = 0,8949 {+-} 0,005. (author)
Improvements in the electromechanical conversion of energy using shock waves; Contribution a la conversion d'energie electromecanique par onde de choc

Energy Technology Data Exchange (ETDEWEB)

Landure, Yves

1971-10-21

This report concerns the electrical mechanical conversion. In this study it was obtained by the depolarization of a ferroelectric ceramic. We are particularly interested by the high electrical horse-power. Shock wave which produces depolarization is created by a gun powder. The speed of the projectile is measured and the pressures generated in the ceramic is determined graphically. The energy freed is released on a linear resistive load. We were able to prove by different parameters how to obtain the maximum electrical energy. On a resistive load of 26 ohms, it was freed 0,91 J/cm{sup 3} in less than 0,5 μs corresponding to an electrical horse-power superior to 2 MW/cm{sup 3}. (author) [French] Ce rapport concerne la conversion d'energie electro-mecanique. Dans cette etude elle est obtenue par la depolarisation d'une ceramique ferro-electrique. Nous nous sommes interesses tout particulierement aux fortes puissances. L'onde de pression produisant la depolarisation est creee par l'impact d'un projectile lance par un canon a poudre. La vitesse du projectile est mesuree et la pression engendree dans la ceramique est determinee graphiquement. L'energie liberee est recueillie sur une impedance de charge lineaire. On a pu mettre en evidence differents parametres permettant d'obtenir l'energie electrique maximale. Sur une charge resistive de 26 ohms, il a ete libere 0,91 j/cm{sup 3} en moins de 0,5 μs, soit une puissance superieure a 2 MW/cm{sup 3}. (auteur)
CO{sub 2} direct cycles suitable for AGR type reactors; Cycles directs de gaz carbonique applicables aux reacteurs du genre AGR

Energy Technology Data Exchange (ETDEWEB)

Maillet, E [Commissariat a l' Energie Atomique. Centre d' Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette (France)

1967-10-01

The perspectives given by the gas turbines under pressure, to build simple nuclear power plants and acieving significantly high yield, are specified. The CO{sub 2} is characterised by by good efficiency under moderate temperature (500 to 750 Celsius degrees), compactness and the simpleness of machines and the safe exploitation (supply, storage, relief cooling, thermosyphon). The revision of thermal properties of the CO{sub 2} and loss elements show that several direct cycles would fit in particular to the AGR type reactors. Cycles that would diverge a little from classical models and able to lead to power and heat generation can lead by simple means to the best results. Several satisfying solutions present for the starting up, the power regulation and the stopping. The nuclear power plant components and the functioning safety are equally considered in the present report. The conclusions stimulate the studies and realizations of carbon dioxide gas turbines in when approprite. [French] Les perspectives offertes par la turbine a gaz sous pression, pour construire des centrales nucleaires simples et de rendement progressivement eleve, se precisent actuellement. le CO{sub 2} se distingue par sa bonne efficacite a temperature moderee (500 a 750 degres celsius), la compacite et la simplicite des machines, et la surete qu'il apporte a l'exploitation ( approvisionnement, stockage, refroidissement de secours, thermosiphon). La revision des proprietes thermophysiques du CO{sub 2} et des elements de pertes montre que divers cycles directs conviendraient en particulier aux reacteurs agr ou derives. Des cycles s'ecartant peu des modeles classiques, et se pretant ulterieurement a la production simultanee d'electricite et de chaleur, peuvent conduire par des moyens simples aux meilleurs resultats d'ensemble. Plusieurs solutions satisfaisantes se presentent pour le demarrage, le reglage de la puissance et l'arret. Les composants de la centrale et la surete de fonctionnement sont
Reactor Physics Development for Advanced Gas-Cooled Reactors; Recherches en Physique des Reacteurs, pour des Reacteurs Perfectionnes Refroidis par un Gaz; Razrabotka metodov v oblasti reaktornoj fiziki dlya usovershenstvovannogo reaktora s gazovym okhlazhdeniem; Progresos de la Fisica de los Reactores de Tipo Avanzado Refrigerados por Gas

Energy Technology Data Exchange (ETDEWEB)

Moore, J. [United Kingdom Atomic Energy Authority (United Kingdom)

1964-04-15

effects in APEX, HERO and AGR and for determining fine structure data and power distribution in the complex fuel assemblies are of particular interest. Current and future theoretical work is concentrated primarily on development of an alternative method to hetrecontrol and FTD2 for dealing with reactor cores after considerable burn-up of the fuel. The experimental programme on HERO is designed to test these methods with complex cores including plutonium bearing fuel. Additional information on the effect of plutonium will be derived from operation of AGR and physics measurements on fuel after irradiation. (author) [French] Le memoire relate les recherches experimentales et theoriques auxquelles on a procede lois de l'etude, de la realisation et de la mise en service du reacteur perfectionne refroidi par un gaz (AGR) de Windscale et, d'une facon generale, pour la mise au point d'un filiere de ce type en vue de la production d'energie electrique industrielle. Il decrit l'important volume de travail qui a ete necessaire en vue d'elaborer les methodes theoriques voulues pour calculer: a) la repartition du flux et l'equilibre de la reactivite dans un coeur complexe; b) la repartition de la puissance dans des geometries de combustible complexes-, c) les effets de l'irradiation sur le cycle du combustible et la repartition de la puissance. A titre d'introduction, le memoire resume la documentation experimentale et les methodes theoriques qui sont le resultat des recherches sur la filiere a uranium gaine de magnox et decrit la documentation experimentale obtenue par le programme commun des industries britanniques (BICEP); toutes ces donnees ont servi de point de depart pour l'elaboration de methodes theoriques applicables a l'AGR. On s'est servi de l'ensemble critique APEX et du reacteur HERO de puissance zero avec des configurations de reseau regulieres et diverses combinaisons de perturbateurs (notamment des barres de commande) pour calculer les parametres de reseau de l'AGR et
Conception et calibration d'un sonoreacteur pour l'oxydation de la cellulose par le systeme TEMPO/NaOCl/NaBr

Science.gov (United States)

Paquin, Michel

grande consommation d'energie et de reactif qui rend le procede difficilement accessible au milieu industriel. L'utilisation des ultrasons lors de la reaction d'oxydation permet de reduire de 50% le temps de reaction et d'autant la consommation de produits chimiques. Actuellement le processus d'oxydation s'effectue en mode discontinu pour une quantite de 20 grammes de pate dans un reacteur en verre dans un bain a ultrason. L'objectif principal de ce travail est d'elaborer un sonoreacteur en mode semi-continu afin d'etre en mesure de transferer une reaction d'oxydation du mode discontinu en mode semi-continu. Le transfert de reaction sera effectue en realisant la calibration de l'activite acoustique des deux differents reacteurs, discontinu et semi-continu, par la methode de Weissler. La methode de Weissler quantifie le taux de production radicalaire en mesurant la formation d'iode moleculaire d'une solution aqueuse d'iodure de potassium sous ultrason. Suite a sa calibration, le sonoreacteur pilote (mode semi-continu) a demontre une augmentation de la production radicalaire de 683 % a 170 kHz en comparaison avec l'utilisation d'un bain a ultrason a la meme frequence. Lors de la reaction d'oxydation, la puissance optimale utilisee dans le bain a ultrason a 170 kHz est de 1000 W. La puissance utilisee selon les resultats de calibration obtenue dans le sonoreacteur pilote est de 125 W soit une diminution de l'energie appliquee de 87,5 %. Lors de la reaction d'oxydation, le taux de production des groupements carboxylates est de 2,6 mmol COOH kg/min dans le bain a ultrason et de 6,87 mmol COOH kg/min dans le sonoreacteur pilote soit une augmentation de 164% du taux de formation. Selon les resultats obtenus, l'utilisation d'un sonoreacteur en mode continu peut etre envisageable pour la reaction d'oxydation de la cellulose par le systeme TEMPO-NaOCl-NaBr en industrie au niveau industriel.
Power Reactor Design at Zero Power; Etudes de Reacteurs de Puissance, au Moyen de Machines de Puissance Zero; Konstruktsiya ehnergeticheskogo reaktora nulevoj moshchnosti; Diseno de Reactores Generadores con Ayuda de Reactores de Potencia Nula

Energy Technology Data Exchange (ETDEWEB)

Redman, W. C.; Plumlee, K. E.; Baird, Q. L. [Argonne National Laboratory, Argonne, IL (United States)

1964-02-15

choisi soit des montages exponentiels, soit des assemblages critiques non empoisonnes, soit des maquettes de puissance nulle, soit des experiences in situ pour obtenir les donnees necessaires, et indiquent quel role ont joue les travaux analytique' complementaires. Ils montrent, par des exemples precis, dans quelle mesure on peut obtenir des donnees sur la physique d'un reacteur avant son fonctionnement en puissance. Ces donnees comprennent la marge d'arret, l'excedent de reactivite pour les besoins de l'exploitation, les coefficients de temperature, l'efficacite des barres de reglage et de securite, la cinetique du reacteur, le regime de la production d'energie, les conditions a remplir en ce qui concerne la source pour le demarrage et la sensibilite des appareils, les besoins en matiere de protection et l'economie des neutrons. Cet expose des experiences faites recemment a la puissance zero montre que par le passe le Laboratoire national d'Argonne s'est largement fonde sur les systemes exponentiels et critiques pour mener a bien ses travaux dans le domaine des etudes de reacteurs. Les auteurs donnent une indication sur le role futur de ces systemes en resumant brievement les programmes de travaux, en cours d'execution ou en projet, au moyen des reacteurs de puissance zero qui existent actuellement a Argonne et de ceux que le Laboratoire se propose de construire. (author) [Spanish] Con el reactor de potencia nula de Argonne se han investigado los diseflos de numerosos reactores de investigacidn, de potencia, de propulsion, de produccion, de isotopos y de ensayo de materiales, habiendose obtenido los datos de caracter fundamental correspondientes en los conjuntos asociados-exponenciales y criticos sin envenenamiento. Con el fin de describir los experimentos mas recientes y demostrar el gran nuemero de datos sobre fisica de reactores que pueden obtenerse en sistemas de flujo debil, los autores exponen los siguientes programas experimentales: 1. Estudio de las propiedades
Problems presented by the filtration and sampling of aerosols in the atomic energy programme; Problemes poses par la filtration et le prelevement des aerosols dans le cadre de l'energie atomique

Energy Technology Data Exchange (ETDEWEB)

Cochinal, R [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

1959-07-01

The maximum permissible limits for radioactive aerosols are much lower than those for aerosols encountered in the non-nuclear industries. These limits depend on numerous factors such as: nature of the radiation, half-life, etc. The radioactive aerosols can be prepared by various methods. The filtering of the air in high activity laboratories or in plutonium treatment factories necessitates an installation consisting of: - aspiration filters, - extraction filters of very high efficiency (those used for {alpha} emitter cells: designed to be replaced without incurring contamination risks; those used for {gamma} emitter cells: designed to be replaced by remote control). The filtering in nuclear reactors is also effectuated by filter papers: - the G1 reactor with open circuit: the air coolant is entirely filtered at the entry and on leaving; - the G2, G3 and EDF1 reactors with closed circuits: filtering under pressure of a small portion of the coolant gas. (author) [French] Les limites maxima permises des aerosols radioactifs sont beaucoup plus faibles que celles des aerosols rencontres dans l'industrie classique. Elles dependent de nombreux facteurs tel que: nature du rayonnement, periode radioactive, etc... La formation des aerosols radioactifs est de nature diverse. La filtration des laboratoires de haute activite, ou d'usines d'elaboration de plutonium conduit a des types d'installations comportant: - des filtres d'aspiration; - des filtres d'extraction a rendement extremement eleve (type pour cellules emettrices {alpha} concu pour etre change sans risque de contamination, type pour cellules emettrices {gamma}: concu pour etre change a distance) La filtration des reacteurs nucleaires sont egalement effectuee par des papiers filtres: - reacteur G1 a circuit ouvert: air de refroidissement totalement filtre a l'aspiration et a l'extraction; - reacteurs G2, G3, EDF1: a circuit ferme: filtration sous pression d'une faible partie du gaz de refroidissement. (auteur)
A new detector for the measurement of neutron flux in nuclear reactors; Nouvelle methode de mesure des flux de neutrons dans les reacteurs atomiques

Energy Technology Data Exchange (ETDEWEB)

Koch, L; Labeyrie, J; Tarassenko, S [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1958-07-01

The detector described is designed for the instantaneous measurement of thermal neutron fluxes, in the presence of high {gamma} ray activity; this detector can withstand temperatures as high as 500 deg. C. It is based on the following principle: radioactive atoms resulting from heavy-nucleus fission are carried by a gas flow to a detector recording their {beta} and {gamma} disintegration. Thermal neutron fluxes as low as few neutrons per cm{sup 2} per second can be measured. This detector may be used to control a nuclear reactor, to plot the thermal flux distribution with an excellent definition (1 mm{sup 2}) for fluxes higher than 10{sup 8} n/cm{sup 2}/s. The time response of the system to a sharp variation of flux is limited, in case of large fluxes, to the transit time of the gas flow between the fission product emitter and the detector; of the order of one tenth of a sec per meter of piping. The detector may also be applied for spectroscopy of fission products eider than 0,1 s. (author)Fren. [French] On decrit un appareil permettant la mesure instantanee des flux de neutrons thermiques accompagnes de flux intenses de rayons {gamma} et situes dans des enceintes pouvant etre portees a des temperatures superieures a 500 deg. C. On utilise la radioactivite des atomes resultant de la fission des noyaux lourds; ces atomes sont entraines par un courant gazeux vers un detecteur de radioactivite qui enregistre leurs desintegrations {beta} et {gamma}. On peut mesurer des flux partir de quelques neutrons thermiques par cm{sup 2} et par seconde. L'appareil permet de suivre la puissance d'un reacteur atomique, de tracer des cartes de densite de neutrons avec une tres bonne definition (1 mm{sup 2}) dans le cas de flux superieurs a 10{sup 8} cm{sup 2}/s. Le temps de reponse du systeme a une variation du flux de neutrons est limite, poes flux importants, par le temps de transit du gaz entre l'emetteur de produits de fission et le detecteur: soit quelques dizaines de
Partial combustion of a fuel cartridge in reactor G1; Combustion partielle d'une cartouche de combustible dans le reacteur G 1

Energy Technology Data Exchange (ETDEWEB)

De, Rouville; Leduc,; Segot, [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1958-07-01

-devices, some null regulating tension systems, annealing the background due to continuous pollution. This event has been fruitful. A grid trap has been set right ahead the reactor. Stricter instructions have been given for rising power operations and automatic burst slug sy (already improved as said above) has been duplicated by a human control. At last, the fault has pointed out that the reactors with gap had the disadvantage of facilitating the contamination of channels from one to another. On the other hand, graphite stores the radioactive dusts and hinders an easy decontamination. (author) [French] Le 26 octobre 1956, le reacteur G1 etait remis en marche apres un arret de quelques jours. L'installation de detection de rupture de gaines donna un premier signal de prealerte a 19h07 cote chargement, un second a 19h13 cote dechargement, puis d'autres. Le chef de quart ordonna a 19h15 une baisse rapide de la puissance mais voulant reperer le canal fautif avec precision la fit remonter ensuite a 2 puis a 5 MW. Bientot, par crainte de contamination exterieure, on dut arreter l'exploration et c'est par detection {gamma} a l'exterieur des tuyaux de detection de rupture de gaine qu'on identifia la cartouche endommagee dans le canal 19-13. Les enregistrements des stations de sante montrerent que les pointes observees etaient restees notablement inferieures aux limites maxima admissibles. L'examen methodique et le degagement du canal accidente occuperent trois semaines. On put apercevoir cote chargement les billettes d'uranium nues sur un lit de poudre de magnesie; cote dechargement, la gaine etait intacte mais l'extremite de la cartouche 'pendait' a l'interieur de la fente d'arrivee d'air. Repoussee cote chargement d'environ 30 cm, la cartouche se bloqua. Apres des essais divers, toujours sous injection d'argon, et avec des protections severes du personnel, on mit en oeuvre un tube fraise, analogue a ceux utilises pour les forages. On nettoya le canal par aspiration, sans toutefois
The Role of Non-Destructive Testing in Test-Reactor Operation at the National Reactor Testing Station; Role des Essais Non Destructifs dans l'Exploitation des Reacteurs d'Essai au Centre National d'Essais de Reacteurs; Rol' nedestruktivnykh ispytanij pri ehkspluatatsii ispytatel'nykh reaktorov na natsional'noj stantsii po ispytaniyam reaktorov; Papel de los Metodos No Destructivos en la Explotacion de los Reactores de la National Reactor Testing Station

Energy Technology Data Exchange (ETDEWEB)

Francis, W. C.; Brown, E. S.; Burdick, E. E.; Gibson, G. W.; Tingey, F. H. [Phillips Petroleum Company, Atomic Energy Division, Idaho Falls, Idaho (United States)

1965-10-15

surface cracks, thermal anneal tests for blistering, and gamma-scanning of irradiated plates. Hydraulic testing of statistical sampling of fuel elements is used to confirm structural integrity, particularly the fuel plate-side plate-joint strength. A continuous effort is made to improve existing techniques and to develop new non-destructive inspection procedures. (author) [French] Les investissements tres importants (plus de 100 millions de dollars) consacres aux reacteurs d'essai du Centre national d'essais de reacteurs et la necessite d'exploiter ces reacteurs en toute securite exigent un controle extremement strict de la qualite des reacteurs et de leurs parties constitutives, notamment des elements combustibles et du dispositif de commande. Les essais non destructifs ont donc joue un role essentiel dans le controle de la qualite de ces pieces avant leur utilisation dans les. reacteurs d'essai. Bien qu'un grand nombre de ces essais non destructifs soient executes selon des procedures bien etablies, on a mis au point de nombreuses methodes inedites et introduit de nouvelles utilisations du materiel classique. On applique depuis longtemps au Centre d'essais les methodes ultrasonores pour la detection des cavites, des defauts de liaison et des craquelures internes. Recemment, on a etendu ces methodes a l'exploration automatique des plaques courbes et a l'inspection des elements combustibles irradies dans les canaux de stockage. Des travaux tres interessants ont permis d'appliquer la methode des ultrasons a la detection des fractures qui peuvent se produire dans l'ame lors du faconnement. Une methode d'exploration par rayons gamma, pour determiner la teneur d'elements combustibles en {sup 23}5{sup U}, s'est revelee tellement fiable qu'elle a ete adoptee pour calculer les penalisations financieres pour les articles non conformes aux specifications. Les radiographies de plaques de combustible donnent les dimensions de l'ame et, associees aux explorations'a l'aide d

General design and main problems of a gas-heavy-water power reactor contained in a pressure vessel; Conception generale et principaux problemes d'un reacteur de puissance eau lourde-gaz contenu dans un caisson resistant

Energy Technology Data Exchange (ETDEWEB)

Roche, R.; Gaudez, J.C. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

In the framework of research carried out on a CO{sub 2}-cooled power reactor moderated by heavy water, the so-called 'pressure vessel' solution involves the total integration of the core, of the primary circuit (exchanges and blowers) and of the fuel handling machine inside a single, strong, sealed vessel made of pre-stressed concrete. A vertical design has been chosen: the handling 'attic' is placed above the core, the exchanges being underneath. This solution makes it possible to standardize the type of reactor which is moderated by heavy-water or graphite and cooled by a downward stream of carbon dioxide gas; it has certain advantages and disadvantages with respect to the pressure tube solution and these are considered in detail in this report. Extrapolation presents in particular.problems due specifically to the heavy water (for example its cooling,its purification, the balancing of the pressures of the heavy water and of the gas, the assembling of the internal structures, the height of the attic, etc. (authors) [French] Dans le cadre des etudes d'un reacteur de puissance modere a l'eau lourde et refroidi-au gaz carbonique, la solution dite 'en caisson' consiste en une integration totale du coeur, du circuit primaire (echangeurs et soufflantes) et du dispositif de manutention du combustible a l'interieur d'un meme caisson etanche et resistant en beton precontraint. La disposition envisagee est verticale; le grenier de manutention est dispose au-dessus du coeur, les echangeurs en dessous. Cette solution, qui permet d'uniformiser les types de reacteurs moderes a l'eau lourde ou au graphite et refroidis par une circulation descendante de gaz carbonique presente, par rapport a la solution a tube de force, des avantages et des inconvenients qui sont analyses dans cette etude. L'extrapolation pose, en particulier, des problemes specifiques a l'eau lourde (tels que son refroidissement, son epuration
Kinetic study of the alkaline metals oxidation by dry oxygen; Etude cinetique de l'oxydation des metaux alcalins par l'oxygene sec

Energy Technology Data Exchange (ETDEWEB)

Touzain, Ph [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1967-06-15

The oxidation of lithium, sodium, potassium, rubidium, cesium and sodium-potassium alloys by dry oxygen is studied at several temperatures and in the oxygen pressure range 40 to 400 mmHg. One distinguishes three different oxidation behaviours (inflammation, ignition and slow combustion) whose zones are precised in function of the temperature. The slow oxidation kinetic laws, the composition of oxides and the motive of oxides colorations are determined. At least, the experimental data are construed theoretically. (author) [French] L'oxydation du lithium, du sodium, du potassium, du rubidium, du cesium et des alliages sodium-potassium par l'oxygene sec est etudiee a diverses temperatures et a des pressions comprises entre 40 et 400 mmHg d'oxygene. On distingue trois processus d'oxydation differents (l'inflammation, l'ignition et la combustion lente) dont les domaines en fonction de la temperature sont precises. Les lois cinetiques d'oxydation lente, la nature des oxydes formes ainsi que les causes des colorations de ces oxydes sont determinees. Enfin les resultats obtenus sont interpretes theoriquement. (auteur)
Study of the dry processing of uranium ores; Etude des traitements de minerais d'uranium par voie seche

Energy Technology Data Exchange (ETDEWEB)

Guillet, H

1959-02-01

A description is given of direct fluorination of pre-concentrated uranium ores in order to obtain the hexafluoride. After normal sulfuric acid treatment of the ore to eliminate silica, the uranium is precipitated by a load of lime to obtain: either impure calcium uranate of medium grade, or containing around 10% of uranium. This concentrate is dried in an inert atmosphere and then treated with a current of elementary fluorine. The uranium hexafluoride formed is condensed at the outlet of the reaction vessel and may be used either for reduction to tetrafluoride and the subsequent manufacture of uranium metal or as the initial product in a diffusion plant. (author) [French] Il s'agit d'une description de fluoration directe de preconcentres de minerais d'uranium en vue d'obtention d'hexafluorure. Apres attaque sulfurique normale du minerai, afin d' eliminer la silice, l' uranium est precipite par un toit de chaux pour obtenir: ou uranate de chaux impur de titre moyen, ou uranium de la dizaine du pourcentage. Ce concentre seche en atmosphere inerte est soumis a un courant de fluor elementaire. L'hexafluorure d'uranium forme est condense a la sortie du reacteur et peut etre utilise soit apres reduction en tetrafluorure par l'elaboration d'uranium metal, soit comme produit de base dans le cadre d'une usine de diffusion. (auteur)
Purification by molecular sieve of helium used as inert cover gas in nuclear reactors; Epuration de l'helium de couverture des reacteurs nucleaires par adsorption sur tamis moleculaire

Energy Technology Data Exchange (ETDEWEB)

Rozenberg, J; Kahan, H [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1967-07-01

A method carried out at fairly low temperatures (between -50 and -80 deg. C) has been studied for the purification of the helium used as cover gas for heavy water in reactors. The use of the 5A molecular sieve has been adopted because of its superiority over other adsorbents in this temperature range. The particular problems connected with adsorption under dynamic conditions have been dealt with separately. The nitrogen adsorption isotherms have been plotted and the heat of adsorption calculated. (authors) [French] Une methode d'epuration, a temperature moderement basse (comprise entre -50 et -80 deg. C) de l'helium servant de couverture inerte a l'eau lourde des reacteurs a ete etudiee. L'emploi au tamis moleculaire 5A a ete retenu pour la superiorite de celui-ci sur d'autres adsorbants dans ce domaine de temperatures. Les problemes particuliers a l'adsorption en regime dynamique ont ete separement traites. Les isothermes d'adsorption d'azote ont ete tracees et la chaleur d'adsorp. tion calculee. (auteurs)
Kinetic study of the alkaline metals oxidation by dry oxygen; Etude cinetique de l'oxydation des metaux alcalins par l'oxygene sec

Energy Technology Data Exchange (ETDEWEB)

Touzain, Ph. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1967-06-15

The oxidation of lithium, sodium, potassium, rubidium, cesium and sodium-potassium alloys by dry oxygen is studied at several temperatures and in the oxygen pressure range 40 to 400 mmHg. One distinguishes three different oxidation behaviours (inflammation, ignition and slow combustion) whose zones are precised in function of the temperature. The slow oxidation kinetic laws, the composition of oxides and the motive of oxides colorations are determined. At least, the experimental data are construed theoretically. (author) [French] L'oxydation du lithium, du sodium, du potassium, du rubidium, du cesium et des alliages sodium-potassium par l'oxygene sec est etudiee a diverses temperatures et a des pressions comprises entre 40 et 400 mmHg d'oxygene. On distingue trois processus d'oxydation differents (l'inflammation, l'ignition et la combustion lente) dont les domaines en fonction de la temperature sont precises. Les lois cinetiques d'oxydation lente, la nature des oxydes formes ainsi que les causes des colorations de ces oxydes sont determinees. Enfin les resultats obtenus sont interpretes theoriquement. (auteur)
The Application of Non-Metallic Core Materials in a High-Temperature Reactor Experiment; Utilisation de materes non metalliques dans le coeur d'un reacteur experimental a haute temperature; Ispol'zovanie nemetallicheskikh materialov dlya aktivnoj zony vysokotemperaturnogo opytnogo reaktora; Empleo de materiales no metalicos en el nucleo de un reactor experimental de alta temperatura

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Huddle, R. A.U.; Shepherd, L. R. [Organization for Economic Co-Operation and Development, Dragon Project, Atomic Energy Establishment, Winfrith, Dorset (United Kingdom)

1963-11-15

refroidis par un gaz, construire et exploiter, dans le cadre de ce projet, un reacteur experimental de 20 MWth. Le reacteur - dont la construction touche a sa fin - est refroidi a l'helium; la temperature de sortie du coeur est de 750{sup o}C; il emploie de l'uranium-235 comme combustible et du thorium comme matiere fertile. Il est caracterise par l'absence de tout metal dans le coeur du reacteur. En raison'des hautes temperatures, qui peuvent atteindre 1050{sup o}C a la surface des elements combustibles et s'elever au dessus de 1500{sup o}C dans les regions les plus chaudes du combustible, on emploie des materiaux refractaires non metalliques. Le fait que tous les constituants du coeur sont reunis dans l'element combustible permet d'obtenir un rapport eleve entre la surface de transfert de la chaleur et le volume du coeur, d'ou une puissance specifique moyenne elevee pour un ensemble de dimension relativement faible. Chaque element combustible est constitue par un faisceau de tubes de graphite contenant les matieres fissiles et fertiles sous forme de carbure incorpore a des pastilles de graphite. Un courant refroidisseur d'helium traverse le centre de chaque barreau de combustible d'ou il ressort par la base pour etre conduit dans une installation de purification dans laquelle il est debarrasse des produits de fission et autres impuretes avant d'etre achemine de nouveau vers le reacteur. Cette methode permet de reduire la fuite des produits de fission qui, s'echappant du combustible ceramique porte a tres haute temperature, entrent dans le circuit de refroidissement primaire. Les auteurs exposent les problemes lies a la mise au point et a la fabrication du graphite et des elements combustibles ceramiques destines a ce reacteur ainsi que le comportement de ces materiaux dans les conditions de fonctionnement. Ils indiquent les resultats de recherches en pile et dans des boucles d'irradiation. Dans ce programme, tout l'effort se concentre sur la mise au point de reacteurs a
Economic aspects of electricity and industrial heat generating reactors; Aspect economique des reacteurs produisant de l'electricite et de la chaleur industrielle

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Gaussens, J; Moulle, N; Dutheil, F [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Aldebert, J [Institut National des Sciences et Techniques Nucleaires (INSTN), CEA Saclay, 91 - Gif sur Yvette (France)

1964-07-01

specifiques nucleaires et classiques. Ces conditions de rentabilite conduisent a admettre pour les reacteurs ainsi utilises certaines caracteristiques techniques et economiques hors desquelles la competition est improbable. On situe, d'autre part, ces resultats par rapport au marche potentiel de la vapeur et de l'electricite et on est ainsi conduit a examiner certaines utilisations de la chaleur des centrales mixtes telles que l'alimentation de complexes industriels, de divers types de chauffage urbain ou du dessalement des eaux de mer. (auteurs)
Physical measurements in Marcoule reactors (1962); Mesures physiques sur les reacteurs de Marcoule (1962)

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Teste du Bailler, A [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1962-07-01

A brief description of the physical measurements in Marcoule reactors is given here. During commissioning and subsequent years of operation, various experiments ha been carried out to check design data, and improve the operating conditions and also test theoretical models for kinetic studies. (author) [French] On presente une rapide description des mesures physiques effectuees sur les reacteurs de Marcoule. Au cours du demarrage et pendant les premieres annees de fonctionnement de G-2 - G-3, de nombreuses experiences ont ete effectuees pour verifier les donnees du projet, ameliorer les conditions de fonctionnement et eprouver des modeles theoriques de calculs de cinetique. (auteur)
Methods of Containment Adopted for the EL4 Reactor and Projected Heavy-Water, Gas-Cooled Plants; Mode de Confinement Adopte pour le Reacteur EL4 et les Projets de Centrales Eau Lourde-Gaz

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Schulhof, P.; Justin, F. [Commissariat a l' Energie Atomique, Paris (France)

1967-09-15

After a brief description of the plant, the paper explains the principles adopted for preventing the release of waste gas, from the EL4 reactor and refers to some of the difficulties associated with this type of containment. From the economic standpoint, the authors present the results of a comparative civil engineering study of pre-stressed concrete and steel shells for a projected 60 MW(e) power station, giving various values for accidental pressures. They demonstrate the influence of the stress values adopted. (author) [French] Les auteurs rappellent les principes adoptes dans le reacteur EL4 pour le confinement des rejets gazeux, apres une description sommaire des installations. Suivent quelques aspects des difficultes introduites par ce type de confinement. Dans le domaine economique, ils presentent le resultat d'une etude comparative de genie civil d'enceintes en beton precontraint et en acier pour un projet de centrale de 600 MW(e), avec diverses valeurs de pression accidentelle. Dans cette etude, ils font ressortir l'influence des valeurs admises pour le taux de travail des materiaux. (author)
Non-Destructive Examination of the Heat-Affected Zone of Welded Zr-Nb Alloy; Controle Non Destructif de la Zone d'Un Alliage Zr-Nb Affectee par la Chaleur Lors du Soudage; Nedestruktivnoe ispytanie zony svarnogo shva iz tsirkonij-niobij splava, kotoryj podverzhen teplovomu vliyaniyu; Examen No Destructivo de la Zona de Soldadura Afectada por el Calor en las Aleaciones de Circonio y Niobio

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Hanstock, R. F.; Walker, D. C.B. [U.K.A.E.A. Reactor Materials Laboratory, Culcheth (United Kingdom)

1965-10-15

An alloy of zirconium, 2 Vulgar-Fraction-One-Half % niobium has advantages for pressure containment in water-moderated reactors owing to the strength attainable by heat treatment. The corrosion resistance of the alloy under reactor operating conditions is also sensitively affected by heat treatment and zones of low corrosion resistance may be produced in the heat-affected zones of fusion welds. The zones susceptible to corrosion may be identified by autoclave treatment but this is not convenient when extensive pressure circuits are being assembled by welding. It has been found that heat-affected zones susceptible to corrosion can be detected non-destructively by measuring the thermo-electric potential between a heated metallic point probe in contact with particular regions of the weld and adjacent metal. The construction of the thermo-electric probe is similar to one devised by the British Non-ferrous Metals Research Association for measuring plating thickness on metal substrates and a commercially available instrument incorporating this type of probe is, with simple modification, suitable for testing welds in Zr-Nb alloys. An example is given of the variation of probe response across the heat-affected zones of a weld and is compared with an autoclave test for corrosion. (author) [French] Un alliage zirconium-niobium a 2,5% Nb presente des avantages pour les circuits sous pression des reacteurs ralentis par de l'eau, du fait de la resistance mecanique que l'on peut obtenir par traitement thermique. La resistance a la corrosion de l'alliage dans les conditions de fonctionnement du reacteur est sensiblement affectee par le traitement thermique et des zones de faible resistance a la corrosion peuvent se produire au voisinage des soudures par fusion. On peut identifier ces zones par traitement en autoclave, mais cette methode n'est pas applicable dans le cas de longs circuits sous pression que l'on assemble par soudage. On a constate que les zones affectees par la
Economic aspects of electricity and industrial heat generating reactors; Aspect economique des reacteurs produisant de l'electricite et de la chaleur industrielle

Energy Technology Data Exchange (ETDEWEB)

Gaussens, J.; Moulle, N.; Dutheil, F. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Aldebert, J. [Institut National des Sciences et Techniques Nucleaires (INSTN), CEA Saclay, 91 - Gif sur Yvette (France)

1964-07-01

combustibles et des investissements specifiques nucleaires et classiques. Ces conditions de rentabilite conduisent a admettre pour les reacteurs ainsi utilises certaines caracteristiques techniques et economiques hors desquelles la competition est improbable. On situe, d'autre part, ces resultats par rapport au marche potentiel de la vapeur et de l'electricite et on est ainsi conduit a examiner certaines utilisations de la chaleur des centrales mixtes telles que l'alimentation de complexes industriels, de divers types de chauffage urbain ou du dessalement des eaux de mer. (auteurs)
Study of the dry processing of uranium ores; Etude des traitements de minerais d'uranium par voie seche

Energy Technology Data Exchange (ETDEWEB)

Guillet, H

1959-02-01

A description is given of direct fluorination of pre-concentrated uranium ores in order to obtain the hexafluoride. After normal sulfuric acid treatment of the ore to eliminate silica, the uranium is precipitated by a load of lime to obtain: either impure calcium uranate of medium grade, or containing around 10% of uranium. This concentrate is dried in an inert atmosphere and then treated with a current of elementary fluorine. The uranium hexafluoride formed is condensed at the outlet of the reaction vessel and may be used either for reduction to tetrafluoride and the subsequent manufacture of uranium metal or as the initial product in a diffusion plant. (author) [French] Il s'agit d'une description de fluoration directe de preconcentres de minerais d'uranium en vue d'obtention d'hexafluorure. Apres attaque sulfurique normale du minerai, afin d' eliminer la silice, l' uranium est precipite par un toit de chaux pour obtenir: ou uranate de chaux impur de titre moyen, ou uranium de la dizaine du pourcentage. Ce concentre seche en atmosphere inerte est soumis a un courant de fluor elementaire. L'hexafluorure d'uranium forme est condense a la sortie du reacteur et peut etre utilise soit apres reduction en tetrafluorure par l'elaboration d'uranium metal, soit comme produit de base dans le cadre d'une usine de diffusion. (auteur)
The influence of the (n, 2n) and (n, {alpha}) reactions of beryllium on the neutron balance in a BeO or Be moderated reactor and its consequences on the long term reactivity changes; Influence des reactions (n, 2n) et (n, {alpha}) du beryllium sur le bilan neutronique d'un reacteur modere a l'oxyde de beryllium ou au beryllium. Consequences sur l'evolution a long terme de la reactivite

Energy Technology Data Exchange (ETDEWEB)

Sahai, K; Benoist, P; Horowitz, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1958-07-01

The reaction probabilities in an infinite and homogeneous medium of BeO or Be have been calculated from neutron cross-section curves, for a neutron produced with an energy distribution similar to a fission spectrum; the calculation shows that, after several elastic collisions, the neutron has yet an appreciable probability to undergo a reaction, in spite of the energy degradation in the spectrum due to each collision. This degradation has been calculated, taking into account of anisotropy of the collisions. The gain of the reactivity in a reactor has been obtained after correcting these probabilities for the attenuation of the flux of fission neutrons due to the inelastic scattering in the uranium. Finally, the calculation shows that in a power reactor, this gain of reactivity is in practice destroyed in a few years by the accumulation of poisonous nuclei such as Li{sup 6} and He{sup 3} following (n, {alpha}) reaction. (author) [French] Les probabilites de reaction en milieu infini et homogene de glucine (BeO) ou de beryllium ont ete calculees a partir des courbes de section efficace pour un neutron naissant suivant un spectre de fission; le calcul montre qu'apres plusieurs diffusions elastiques le neutron a encore une probabilite appreciable de subir une reaction, malgre la degradation du spectre a chaque diffusion; cette degradation a ete calculee en tenant compte de l'anisotropie du choc. Le gain de reactivite dans un reacteur a ensuite ete obtenu en corrigeant les probabilites en milieu homogene de l'effet l'attenuation du flux des neutrons de fission par les chocs inelastiques dans les barres d'uranium. Enfin, le calcul montre que, dans un reacteur de puissance, ce gain de reactivite est pratiquement detruit en peu d'annees par l'accumulation de noyaux poisons Li{sup 6} et He{sup 3} consecutive a la reaction (n, {alpha}). (auteur)
Use of cadmium in solution in the EL 4 reactor moderator irreversible fixing of cadmium on the metallic surfaces; Utilisation du cadmium en solution dans le moderateur du reacteur EL 4 - fixation irreversible du cadmium sur les surfaces metalliques

Energy Technology Data Exchange (ETDEWEB)

Croix, O; Paoli, O; Lecomte, J; Dolle, L; Gallic, Y [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

In the framework of research into the poisoning of the EL-4 reactor by cadmium sulphate, measurements have been made by two different methods of the residual amounts of cadmium liable to be fixed irreversibly on the surfaces in contact with the heavy water. A marked influence of the pH has been noticed. The mechanism of the irreversible fixing is compatible with the hypothesis of an ion-exchange in the surface oxide layer. In a sufficiently wide range of pH the cadmium thus fixed causes very little residual poisoning. The stability of the cadmium sulphate solutions is however rather low in the conditions of poisoning. (authors) [French] Dans le cadre des etudes sur l'empoisonnement du reacteur EL-4 par le sulfate de cadmium, les quantites residuelles de cadmium susceptibles de se fixer irreversiblement sur les parois que mouillerait l'eau lourde, ont ete mesurees experimentalement par deux methodes differentes. On observe une influence nette du pH. Le mecanisme de la fixation irreversible est compatible avec l'hypothese d'un echange d'ions dans la pellicule d'oxyde superficielle. Dans des limites suffisamment larges de pH, la cadmium ainsi fixe n'occasionne pas d'empoisonnement residuel important. La stabilite des solutions de sulfate de cadmium dans les conditions de l'empoisonnement est cependant mediocre. (auteurs)
Methods and experimental coefficients used in the computation of reactor shielding; Methodes et coefficients experimentaux pour le calcul des protections de reacteurs

Energy Technology Data Exchange (ETDEWEB)

Bourgeois, J; Lafore, P; Millot, J P; Rastoin, J; Vathaire, F de [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

1959-07-01

1) The concept of an effective removal cross section has been developed in order more easily to compute reactor shielding thicknesses. We have built an experimental facility for the purpose of measuring effective removal cross sections, the value of which had not been published at that time. The first part of this paper describes the device or facility used, the computation method applied, and the results obtained. 2) Starting from this concept, we endeavoured to define a removal cross section as a function of energy. This enabled us to use the method for computations bearing on the attenuation of fast neutrons of any spectrum. An experimental verification was carried out for the case of fission neutrons filtered by a substantial thickness of graphite. 3) Finally, we outline a computation method enabling us to determine the sources of captured gamma rays by the age theory and we give an example of the application in a composite shield. (author) [French] 1) La notion de section efficace effective de deplacement a ete introduite pour calculer commodement les epaisseurs de protection des reacteurs. Nous avons construit un dispositif experimental destine a mesurer les sections efficaces effectives de deplacement dont la valeur n'avait pas ete publiee a cette epoque. La premiere partie de cette communication decrit le dispositif utilise, la methode de calcul employee et les resultats obtenus. 2) A partir de cette notion, nous avons essaye de definir une section efficace de deplacement fonction de l'energie. Ceci permet d'utiliser la methode du deplacement pour des calculs d'attenuation de neutrons rapides dont le spectre est quelconque. Une verification experimentale a ete faite dans le cas de neutrons de fission filtres par une epaisseur notable de graphite. 3) Enfin une methode de calcul permettant de determiner les sources de gamma de capture par la theorie de l'age est exposee et un exemple d'application donne dans une protection composite. (auteur)
Methods and experimental coefficients used in the computation of reactor shielding; Methodes et coefficients experimentaux pour le calcul des protections de reacteurs

Energy Technology Data Exchange (ETDEWEB)

Bourgeois, J; Lafore, P; Millot, J P; Rastoin, J; Vathaire, F de [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1958-07-01

1. The concept of an effective removal cross section has been developed in order more easily to compute reactor shielding thicknesses. We have built an experimental facility for the purpose of measuring effective removal cross sections, the value of which had not been published at that time. The first part of this paper describes the device or facility used, the computation method applied, and the results obtained. 2. Starting from this concept, we endeavored to define a removal cross section as a function of energy. This enabled us to use the method for computations bearing on the attenuation of fast neutrons of any spectrum. An experimental verification was carried out for the case of fission neutrons filtered by a substantial thickness of graphite. 3. Finally, we outline a computation method enabling us to determine the sources of captured gamma rays by the age theory and we give an example of the application in a composite shield. (author)Fren. [French] 1. La notion de section efficace effective de deplacement a ete introduite pour calculer commodement les epaisseurs de protection des reacteurs. Nous avons construit un dispositif experimental destine a mesurer les sections efficaces effectives de deplacement dont la valeur n'avait pas ete publiee a cette epoque. La premiere partie de cette communication decrit le dispositif utilise, la methode de calcul employee et les resultats obtenus. 2. A partir de cette notion, nous avons essaye de definir une section efficace de deplacement fonction de l'energie. Ceci permet d'utiliser la methode du deplacement pour des calculs d'attenuation de neutrons rapides dont le spectre est quelconque. Une verification experimentale a ete faite dans le cas de neutrons de fission filtres par une epaisseur notable de graphite. 3. Enfin une mde de calcul permettant de determiner les sources de gamma de capture par la theorie de l'age est exposee et un exemple d'application donne dans une protection composite. (auteur)
Description of the french graphite reactor and of the experiments performed in 1956; Presentation du premier reacteur a graphite francais et des experiences effectuees en 1956

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Bussac, J; Leduc, C; Zaleski, C P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1957-07-01

This paper is an introduction to the experiments performed on the G1 reactor, experiments fully described in the papers following (670 'B to P'). The main results are given together with some comments. The neutronic parameters of the core, a description of the most important structures, and a few words of the tests leading to normal operation of the reactor under load complete our survey. (author) [French] Ce rapport presente les experiences qui furent faites sur le reacteur G1 et dont la description en detail fait l'objet des rapports suivants (670 'B a P'). Les principaux resultats sont fournis ici et commentes. On trouvera en outre les caracteristiques neutroniques du coeur actif de la pile, une description des principales installations et une mention des essais qui ont conduit au fonctionnement normal du reacteur en puissance. (auteur)
Experience gained in two years operation of G1; Experience acquise au cours de deux ans de fonctionnement du reacteur G1

Energy Technology Data Exchange (ETDEWEB)

de, Rouville; Pascal, [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Scalliet, [Electricite de France (EDF), 75 - Paris (France)

1958-07-01

Technical specifications in respect of the first plutonium generating graphite reactor, the G1 at Marcoule, were stated in a paper read at the first Geneva Conference in 1955. We shall not therefore deal further with the technical characteristics of G1 in the present note, but rather propose to define - in the characteristic fields we think will be of major interest to foreign specialists - the results obtained in two and a half years operation since G1 first became critical on january 7, 1956. (author)Fren. [French] Les caracteristiques techniques du premier reacteur plutonigene, au graphite, de Marcoule, G1, ont ete donnees dans une communication presentee a la premiere conference de Geneve, en 1955. Nous n'y reviendrons donc pas dans la presente note qui a pour objet de faire le point, dans quelques domaines caracteristiques, qui nous ont paru les plus susceptibles d'interesser les specialistes etrangers, des resultats obtenus et des experiences faites au cours des deux annees et demi de fonctionnement du reacteur qui ont suivi sa divergence, le 7 janvier 1956. (auteur)
A pulsed fast reactor; Un reacteur pulse a neutrons rapides; Impul'snyj reaktor na bystrykh nejtronakh; Reactor rapido pulsado

Energy Technology Data Exchange (ETDEWEB)

Blokhin, G. E.; Blokhintsev, D. I.; Blyumkina, Yu. A.; Bondarenko, I. I.; Deryagin, B. N.; Zajmovskij, A. S.; Zinov' ev, V. P.; Kazachkovskij, O. D.; Krasnoyarov, N. V.; Lejpunskij, A. I.; Malykh, V. A.; Nazarov, P. M.; Nikolaev, S. K.; Stavisskij, Yu. Ya.; Ukraintsev, F. I.; Frank, I. M.; Shapiro, F. Ji.; Yazvitskij, Yu. S. [Akademiya Nauk, Moscow, SSSR (Russian Federation)

1962-03-15

fonctionne a la puissance nominale depuis le mois de decembre 1960. Ce reacteur est utilise comme source puisee de neutrons pour les experiences de physique fondees sur la methode du temps de vol. On l'emploie pour etablir la section efficace totale et la section efficace de capture des neutrons intermediaires, pour etudier l'interaction des neutrons lents et des corps solides ou liquides et pour mesurer les spectres neutroniques dans differents milieux. Le memoire decrit les caracteristique s essentielles de la construction du reacteur et les resultats d'experiences faites a l'aide de ce reacteur. Le regime de fonctionnemen t normal est celui des impulsions periodiques. Les impulsions de puissance sont produites par un deplacement rapide de la partie mobile du coeur a travers sa partie immobile. La partie mobile se trouve fixee sur un disque tournant et se deplace a une vitesse d'environ 230 m/s. Une zone mobile auxiliaire permet de modifier la frequence des impulsions de puissance entre 2,3 et 88 ips. Le reacteur a une puissance moyenne de 1 kW. La demi-largeur d'une impulsion de puissance est de 36 {mu}/s. Le reacteur est dote d'un systeme de commande et de securite qui assure le maintien automatique de la puissance moyenne et un arret rapide en cas de fonctionnement irregulier. Il est equipe d'un systeme de canalisations sous vide pour le passage des neutrons, qui permettent de mesurer le temps de vol. Le canal principal a 1000 m de long. Lors du demarrage du reacteur et durant les experiences de physique dont il a fait l'objet, on a etudie l'effet que produit sur la reactivite le deplacement des organes de commande et des parties mobiles du coeur; on a mesure la longueur des impulsions a des regimes de fonctionnement differents et etudie les fluctuations d'amplitude des impulsions de puissance. En outre, les auteurs ont procede a des mesures en vue de determiner la duree de vie des neutrons instantanes, la fraction effective de neutrons retardes et les coefficients de
Development and testing of the EDF-2 reactor fuel element; Essais et mise au point de l'element combustible pour le reacteur EDF-2

Energy Technology Data Exchange (ETDEWEB)

Delpeyroux, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Furhmann, R [Societe Industrielle de Combustible Nucleaire (France)

1964-07-01

rassemble les etudes qui ont ete necessaires pour mener a bien la definition de l'element combustible EdF 2. Apres un bref rappel des caracteristiques du reacteur EdF 2 et des options preliminaires ayant permis de fixer un avant-projet d'element combustible, on aborde les etudes proprement dites: - Etudes uranium: essais de passage d'une couronne interne du tube en phase {beta}, flechage du tube sous l'action d'une force concentree, soudage des pastilles d'extremites et verification de leur etancheite. La tenue du tube a l'ecrasement et la resistance des pastilles a l'enfoncement sous l'action de la pression externe sont etudiees en detail dans un autre rapport CEA - Etudes gaine: rappel des conditions de fabrication et verification de l'etancheite de la gaine, tenue des ailettes au fluage sous l'action du courant gazeux - Etudes d'extremites: fluage en compression et soudage des bouchons a la gaine. - Etudes cartouche: determination des caracteristiques des gorges d'ancrage gaine-combustible et des conditions de gainage, verification de la tenue au cyclage thermique de l'element combustible, determination de la chute de temperature au contact gaine-combustible traitee en detail dans un autre rapport CEA, - Etudes de l'ensemble: les etudes se rapportant a la chemise de graphite, au support et aux vibrations de la cartouche ont ete traitees par le service des Etudes Mecaniques et Thermiques (Section de Mecanique), Dans ce domaine, la Section d'Etude d'Elements Combustibles a etudie la tenue des centreurs sous l'action du courant gazeux. L'aboutissement des etudes est constitue par le dessin de l'element combustible, le schema de fabrication et les normes de fabrication. La validite de l'ensemble de ces essais hors pile sera confirmee par des assais en pile qui sont en cours et par l'irradiation des elements dans le reacteur EdF 2 lui-meme. En conclusion, on donne l'orientation des etudes pour l'amelioration de l'element combustible et la definition d'un element combustible

Preliminary handling studies in large size fast piles; Etudes preliminaires de manutention dans les reacteurs a neutrons rapides de grande taille

Energy Technology Data Exchange (ETDEWEB)

Leduc, J.; Marmonier, P. [Association Euratom-CEA Cadarache (France). Centre d' Etudes Nucleaires

1964-07-01

This report examines the various fuel handling systems which presently seem feasible for a fast power reactor. It tries to point out the advantages and / or the the disadvantages and the fabrication problems for each solution involved and makes, a tentative to evaluate the time required for a fuel loading and / or unloading operation. One has investigated the influence of the maximum allowable irradiation, the number of of shut-downs, the power distribution shape within the core on the storage capacity needed, the load factor expected and the average irradiation obtained. (authors) [French] On a examine dans ce rapport les differents systemes de manutention, qui semblent actuellement realisables pour un reacteur a neutrons rapides de puissance, en essayant de faire ressortir les avantages, les inconvenients et les difficultes de realisation de chaque systeme, et de chiffer les temps de manutention auxquels ils conduisent. On a aussi regarde l'influence des variations du taux d'irradiation maximal,de la cadence des arrets ou de la forme du flux dans le coeur du reacteur, sur la capacite du stockage, le taux de disponibilite et le taux d'irradiation moyen. (auteurs)
Preliminary handling studies in large size fast piles; Etudes preliminaires de manutention dans les reacteurs a neutrons rapides de grande taille

Energy Technology Data Exchange (ETDEWEB)

Leduc, J; Marmonier, P [Association Euratom-CEA Cadarache (France). Centre d' Etudes Nucleaires

1964-07-01

This report examines the various fuel handling systems which presently seem feasible for a fast power reactor. It tries to point out the advantages and / or the the disadvantages and the fabrication problems for each solution involved and makes, a tentative to evaluate the time required for a fuel loading and / or unloading operation. One has investigated the influence of the maximum allowable irradiation, the number of of shut-downs, the power distribution shape within the core on the storage capacity needed, the load factor expected and the average irradiation obtained. (authors) [French] On a examine dans ce rapport les differents systemes de manutention, qui semblent actuellement realisables pour un reacteur a neutrons rapides de puissance, en essayant de faire ressortir les avantages, les inconvenients et les difficultes de realisation de chaque systeme, et de chiffer les temps de manutention auxquels ils conduisent. On a aussi regarde l'influence des variations du taux d'irradiation maximal,de la cadence des arrets ou de la forme du flux dans le coeur du reacteur, sur la capacite du stockage, le taux de disponibilite et le taux d'irradiation moyen. (auteurs)
Study of the consequences of the rupture of a pressure tube in the tank of a gas-cooled, heavy-water moderated reactor; Etude des consequences de la rupture d'un tube de force dans la cuve d'un reacteur modere a l'eau lourde et refroidi au gaz

Energy Technology Data Exchange (ETDEWEB)

Hareux, F; Roche, R; Vrillon, B [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

Bursting of a pressure tube in the tank of a heavy water moderated-gas cooled reactor is an accident which has been studied experimentally about EL-4. A first test (scale 1) having shown that the burst of a tube does not cause the rupture of adjacent tubes, tests on the tank resistance have been undertaken with a very reduced scale model (1 to 10). It has been found that the tank can endure many bursts of tube without any important deformation. Transient pressure in the tank is an oscillatory weakened wave, the maximum of which (pressure peak) has been the object of a particular experimental study. It appears that the most important parameters which affect the pressure peak are; the pressure of the gas included in the bursting pressure tube, the volume of this gas, the mass of air included in the tank and the nature of the gas. A general method to calculate the pressure peak value in reactor tanks has been elaborated by direct application of experimental data. (authors) [French] L'eclatement d'un tube de force dans la cuve d'un reacteur de puissance modere a l'eau lourde et refroidi par un gaz sous pression est un accident qui a ete etudie experimentalement a propos d'EL-4. Un premier essai a l'echelle 1 ayant montre que l'eclatement d'un tube ne provoque pas celui des tubes voisins, des essais relatifs a la tenue de la cuve ont ete effectues sur maquettes a echelle tres reduite (l/lO). Il a ete trouve que la cuve peut supporter plusieurs eclatements de tubes sans deformations notables. La pression transitoire dans la cuve a une allure oscillatoire amortie dont le maximum (pression de pic) a fait l'objet d'une etude experimentale detaillee. Il apparait que les parametres essentiels influant sur cette pression sont: la pression du gaz contenu dans le tube de force, le volume du gaz qui participe a l'eclatement, la flexibilite de la cuve, la masse d'air empoisonnee dans la cuve, la nature du gaz explosant. Une methode generale d'estimation des pics de pression dans
Absolute measurement of a standard thermal-neutron flux using gold-detector activation; Mesure absolue d'un flux etalon de neutrons thermiques par activation de detecteurs d'or

Energy Technology Data Exchange (ETDEWEB)

Paternot, Y [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

1967-02-15

The density of neutrons in a standard stacking is determined between the zero-energy and the cut-off energy of 1 mm thick cadmium unit using a gold detector. Its absolute activity is measured using a 4 {pi} {beta} counter calibrated for 4 {pi} {beta},{gamma} coincidence by counting strongly active sources. The correction factor F due to the disintegration process for the gold is determined experimentally. {phi}{sub 0} = N{sub 0} {sup E}Cd{sub V0} = 6495 {+-} 1.5 per cent n/cm{sup 2}/s. (author) [French] La densite de neutrons dans un empilement etalon est determinee entre l'energie zero et l'energie de coupure d'un boitier de cadmium de 1 mm d'epaisseur au moyen d'un detecteur d'or. Son activite absolue est mesuree a l'aide d'un compteur 4 {pi} {beta} etalonne en coincidence 4 {pi} {beta},{gamma} par comptage de sources fortement actives. Le facteur de correction F d au schema de desintegration de l'or est determine experimentalement. {phi}{sub 0} = N{sub 0} {sup E}Cd{sub V0} = 6495 {+-} 1.5 pour cent n/cm{sup 2}/s. (auteur)
Extraction of sulphates by long chain amines; Extraction des sulfates par les amines a longues chaines

Energy Technology Data Exchange (ETDEWEB)

Boirie, Ch [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1959-05-15

The extraction of sulphuric acid by long chain amines in organic solution has been studied with a view to determining the value of the stability constants of the amine sulphates and bi-sulphates formed. We have concentrated chiefly on uranium sulphate and thorium sulphate. The formulae of the complexes extractable with amines have been established, as well as the corresponding dissociation constants. We have observed that for uranium sulphate the formula of the complex depends only on the nature of the amine, whereas for thorium this formula varies with the amine structure. From the formulae determined and the value of the constants calculated, we have been able to establish the best conditions for uranium and thorium extraction and also for a separation of these two elements. Finally we propose an application of this study to the determination of uranium in ores, where the separation of uranium by this method is particularly easy and complete. (author) [French] L'extraction de l'acide sulfurique par des amines a longues chaines en solution organique a ete etudiee en vue de la determination de la valeur des constantes de stabilite des sulfates et bisulfates d'amines formes. Parmi les sulfates, nous nous sommes particulierement interesses au sulfate d'uranium et au sulfate de thorium. Nous avons determine les formules des complexes extractibles avec les amines, ainsi que les constantes de dissociation correspondantes. Nous avons remarque que pour le sulfate d'uranium, la formule du complexe ne depend que de la nature de l'amine, alors que pour le thorium cette formule varie avec la structure de l'amine. Les formules determinees et la valeur des constantes calculees, nous ont permis de decrire les meilleures conditions d'extraction de l'uranium et du thorium ainsi que celles d'une separation de ces deux elements. Nous proposons enfin une application de cette etude au dosage de l'uranium dans les minerais, ou la separation de l'uranium par cette methode est
G2 - G3 inventive properties, the first french nuclear plants; Caracteristiques generales et aspects originaux des reacteurs G2 et G3

Energy Technology Data Exchange (ETDEWEB)

Pascal,; Horowitz,; Bussac,; Joatton,; de Meux, De Lagge; Martin, [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1958-07-01

This paper points out the inventive properties of the frenchctors G2 and G3. These are dual purpose reactors, i.e. designed for the production of both plutonium and energy (30 electrical MW); in this respect, they can be considered as the start point of the french electrical energy produced from nuclear fuel. The following points are specially discussed in this paper: the choice of the prestressed concrete pressure vessel, the horizontal arrangement of the channels, the interest of neutron flux flattening, the advantages of the charging and discharging device working during pile operation. (author)Fren. [French] Les caracteres originaux des reacteurs fran is G2 et G3 sont decrits dans ce rapport. Ce sont des reacteurs a double fin, plutonigenes et aussi producteurs d'energie (30 MW electriques); ils constituent a ce titre le point de depart de la production fran ise d'electricite d'origine nucleaire. Sont discutes, en particulier, dans ce rapport: le choix du caisson en beton precontraint pour tenir la pression, la disposition horizontale des canaux, l'interet de l'aplatissement du flux neutronique, les avantages de l'appareil permettant le chargement et le dechargement du combustible sans arreter la pile. (auteur)
Group cross-sections for fast reactors; Sections efficaces de groupes pour les reacteurs a neutrons rapides; Gruppovye secheniya reaktorov na bystrykh nejtronakh; Secciones eficaces de grupos para reactores rapidos

Energy Technology Data Exchange (ETDEWEB)

Zweifel, P P [University of Michigan, Ann Arbor, MI (United States); Ball, G L [Atomic Power Development Associates, Inc., Detroit, MI (United States)

1962-03-15

groupes. Ils montrent notamment que la section efficace moyenne de transport peut, avec une certaine approximation, s'exprimer en termes de libre parcours moyen. Le calcul de cette quantite prend beaucoup de temps, car elle ne peut se reduire en moyennes elementaires; neanmoins, on a demontre certaines inegalites, qui simplifient la methode de calcul des moyennes qui doit etre utilisee. Les auteurs analysent trois autres aspects des sections efficaces de groupes, que l'on neglige souvent, mais qu'il peut etre important de connaitre pour les etudes de reacteurs. a) Il est injustifie d'utiliser pour tous les reacteurs a neutrons rapides le meme ensemble de sections efficaces dont la moyenne par groupe a ete calculee si les spectres des differents reacteurs sont dissemblables et si les sections efficaces varient rapidement a l'interieur du groupe, comme c'est le cas le plus souvent. Les auteurs decrivent une methode d'iteration qui permet d'obtenir les valeurs moyennes correctes; ils determinent ensuite, a l'aide de cette methode, dans quelle mesure les calculs de reacteurs sont influences par les effets de spectre. b) Dans les calculs de transport (la methode S{sub n}, par exemple), les moyennes doivent etre calculees en tenant compte a la fois de tous les angles et de toutes les energies. Etant donne qu'on ne peut dissocier dans le flux une partie angulaire et une partie energetique, la plus grande attention est necessaire pour eviter les erreurs. Les auteurs etudient l'equation obtenue par la methode S{sub n} sous la forme d'un modele simple, et en tirent un critere qui pourrait aider a determiner l'importance de la non-separabilite angulaire dans les calculs de reacteurs. c) A partir de raisonnements fondes sur la conservation du nombre de neutrons, il est possible d'obtenir une relation consistant entre les coefficients de diffusion de groupe, le pouvoir de ralentissement et les sections efficaces d'absorption. Les auteurs montrent qu'il n'est pas exact de definir
Aerodynamic and thermal studies of cans of gas cooled fuel elements; Etudes aerodynamiques et thermiques de gaines d'elements combustibles refroidis par gaz

Energy Technology Data Exchange (ETDEWEB)

Gelin, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Milliat, J P [Electricite de France (EDF), 75 - Paris (France)

1964-07-01

l'amelioration des grappes et s'est ensuite poursuivie dans les deux Laboratoires pour le refroidissement interne des elements combustibles annulaires. Au fur et a mesure de l'avancement de ces etudes, les moyens d'essais se sont amplifies tandis que les methodes experimentales n'ont cesse de s'ameliorer. Actuellement, les deux Laboratoires, qui travaillent en pleine collaboration, disposent de moyens puissants. Pour les grappes, l'effort a surtout porte sur les pertes de charge dues aux pieces d'assemblage et sur les variations de temperature autour des elements de la grappe. On est arrive ainsi a determiner d'une facon satisfaisante les points chauds de gaine, les deformations des crayons et les conditions de stabilite de ces deformations. Pour les gaines a chevrons, les etudes ont porte, d'une part sur l'evolution des performances en fonction des parametres geometriques, et, d'autre part sur les singularites aerodynamiques et thermiques creees tant par les ailettes que par les interruptions de cartouche. Ces etudes ont abouti a une connaissance tres complete des cartouches choisies pour les reacteurs EDF2 et EDF3, et ouvrent maintenant des perspectives tres encourageantes pour les reacteurs a venir, en particulier les reacteurs equipes d'elements annulaires; parmi les solutions convenant a la gaine interne de l'element annulaire, les corrugations et les ailettes longitudinales ont fait l'objet d'essais assez etendus dans une large plage de nombre de Reynolds. (auteurs)
Relating to the higher sensitiveness of Frick ferrous sulphate dosimeter by the use of ortho-phenanthroline reagent (1960); Sensibilite accrue du dosimetre a sulfate ferreux de frick par l'utilisation du reactif a l'orthophenanthroline (1960)

Energy Technology Data Exchange (ETDEWEB)

Bouzigues, H; Schbdhauer, J; Brian, R; Messainguiral, L [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

1960-07-01

This paper describes a possible utilization of ferrous sulfate dosimeter by the use of ferrous o. phenanthroline as way of determination of the absorbed dose. The process was applied to the measure of the gamma radiation of radio-cobalt 60 and the relative middle values of the G{sub Fe{sup +}{sup +}} determined with a accuracy of {+-} 2,75 per cent in the range of rates of dose from 1000 to 30000 rad. The chief advantage concerns the coloured complex which is particularly stable. (author) [French] Cette note demontre les possibilites du dosimetre de Frick a sulfate ferreux en utilisant I'orthophenantroline ferreuse pour la mesure de la dose delivree. La methode mise au point pour la determination de la concentration en fer ferreux a ete utilisee pour la mesure de la dose delivree par une source de radiocobalt 60. Entre 1000 et 30000 rad, la valeur relative moyenne du rendement radiochimique a ete determinee a + 2,75 pour cent pres. L'avantage essentiel reside dans la stabilite du complexe colore forme apres irradiation. (auteur)
Directed and persistent movement arises from mechanochemistry of the ParA/ParB system.

Science.gov (United States)

Hu, Longhua; Vecchiarelli, Anthony G; Mizuuchi, Kiyoshi; Neuman, Keir C; Liu, Jian

2015-12-22

The segregation of DNA before cell division is essential for faithful genetic inheritance. In many bacteria, segregation of low-copy number plasmids involves an active partition system composed of a nonspecific DNA-binding ATPase, ParA, and its stimulator protein ParB. The ParA/ParB system drives directed and persistent movement of DNA cargo both in vivo and in vitro. Filament-based models akin to actin/microtubule-driven motility were proposed for plasmid segregation mediated by ParA. Recent experiments challenge this view and suggest that ParA/ParB system motility is driven by a diffusion ratchet mechanism in which ParB-coated plasmid both creates and follows a ParA gradient on the nucleoid surface. However, the detailed mechanism of ParA/ParB-mediated directed and persistent movement remains unknown. Here, we develop a theoretical model describing ParA/ParB-mediated motility. We show that the ParA/ParB system can work as a Brownian ratchet, which effectively couples the ATPase-dependent cycling of ParA-nucleoid affinity to the motion of the ParB-bound cargo. Paradoxically, this resulting processive motion relies on quenching diffusive plasmid motion through a large number of transient ParA/ParB-mediated tethers to the nucleoid surface. Our work thus sheds light on an emergent phenomenon in which nonmotor proteins work collectively via mechanochemical coupling to propel cargos-an ingenious solution shaped by evolution to cope with the lack of processive motor proteins in bacteria.
Possibilities and limitations of analogue methods for studying the dynamics of nuclear power stations; Possibilites et limitations du calcul analogique pour les etudes dynamiques de centrales nucleaires

Energy Technology Data Exchange (ETDEWEB)

Caillet, C; Deat, M [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1958-07-01

1. Introduction: the present paper is devoted to analog simulation of problems related to nuclear reactors other than the simulation of the kinetic equations which is well known. 2. Thermodynamic problems: various problems relative to temperature evolution in a reactor, in a pipe, in an exchanger, in a turbine, are studied, and simulation techniques used by earlier authors are critically reviewed. 3. Pipe simulators: it is shown that this problem can be solved by the use of specialized simulators which will be described and analysed. 4. Rotating machine simulators: the particular aspect of rotating machine calculations introducing frequent use of diagrams is emphasized. A simulator requiring both digital and analogue methods is described. 5. The study of a nuclear power station: as an example it is proposed to discuss problems a rising in connection with the preceding elements (a, b, c, d) when simulating the behaviour of large nuclear plants. The part played by ordinary computing elements for the simulation of the different servomechanism transfer functions is considered and process of regulation is outlined. 6. Conclusion: the necessity of the use of high quality simulators and computers is underlined and the accuracy of the solutions is discussed. (author)Fren. [French] 1. Cinetique des reacteurs: la simulation des equations cinetiques d'un reacteur nucleaire ne pose desormais plus de probleme. II est donc possible de faire le point des differentes applications de la technique analogique dans ce domaine. 2. Les problemes thermodynamiques: on discute les differents problemes poses par l'evolution des temperatures dans un reacteur, dans une tuyauterie, dans un echangeur, dans une turbine, et on passe en revue les techniques de simulation proposees jusqu'a ce jour. 3s simulateurs de tuyauteries: on montre comment les differents problemes poses ci-dessus peuvent etre resolus, pour une classe tres vaste de reacteurs par l'emploi de simulateurs speciaux que l
Integral physics data for fast-reactor design; Donnees de physique integrale intervenant dans les etudes de reacteur a neutrons rapides; Integral'nye fizicheskie dannye dlya raschetov reaktorov na bystrykh nejtronakh; Datos fisicos integrales para el diseno de reactores rapidos

Energy Technology Data Exchange (ETDEWEB)

Loewenstein, W B; Meneghetti, D [Argonne National Laboratory, Argonne, IL (United States)

1962-03-15

systems. (author) [French] La compilation recente du chapitre sur la physique des reacteurs a neutrons rapides dans la preparation de la deuxieme edition de 'Reactor Physics Constants' a entraine une recapitulation des resultats disponibles des mesures experimentales globales. Le choix des donnees integrales connues relatives a la physique des reacteurs a neutrons rapides a faire figurer dans cette compilation a ete fait en fonction de deux criteres : a) informations recueillies a partir de reacteurs relativement simples et qui se pretent a des analyses theoriques simples, et b) informations recueillies a partir de reacteurs complexes, representant des prototypes ou des maquettes, et qui offrent un interet general pour les reacteurs de puissance a neutrons rapides. Le premier critere a pour objet de donner une enumeration des informations concernant les systemes les plus couramment utilises pour verifier les parametres des sections efficaces et les methodes de calcul. Le deuxieme critere est fonde sur la representation des informations courantes concernant les reacteurs a surgeneration, a neutrons rapides, existant. Ces informations sont trop compliquees pour qu'il soit possible de proceder a leur egard a des analyses theoriques simples. Elles prouvent la complexite du reacteur reel, par rapport a l'experience critique plus schematique et plus facile a analyser. Les donnees integrales intervenant dans les calculs de reacteurs sont les resultats des mesures faites, sur des types de reacteurs critiques ou non, des diverses grandeurs de la physique des reacteurs qui presentent un interet pratique et/ou theorique. Elles caracterisent le type de reacteur et aident a sa comprehension. Les mesures portent sur la masse critique, le facteur forme du coeur, les pourcentages de detection, les spectres des neutrons, les experiences de substitution de materiaux, le gain reflecteur, le temps de vie des neutrons, l'{alpha} de Rossi et sur d'autres grandeurs similaires. Les auteurs
EURATOM's Programme of Participation in Power Reactor Construction; Le programme de participation d'Euratom aux reacteurs de puissance; Programma uchastiya v razrabotke ehnergeticheskikh reaktorov Evratoma; El programa de participacion de la Euratom en la construccion y explotacion de reactores de potencia

Energy Technology Data Exchange (ETDEWEB)

Ramadier, R. C.; Parker, E. [Communaute Europoenne de l' Energie Atomique, Bruxelles (Belgium)

1963-10-15

-years during which operating problems will become decisive for the development of atomic power. (author) [French] L'un des moyens mis en oeuvre par la Commission de l'Euratom en vue d'assurer le developpement d'une industrie nucleaire europeenne est un programme dit de ''participation communautaire''. Ce programme permet a la Commission de participer a concurrence de 32 millions d'u.c. AME a des realisations dans le domaine des reacteurs de puissance. La contrepartie est l'acquisition des informations relatives a la conception, la construction, le demarrage et le fonctionnement de ces reacteurs. Jusqu'a present des propositions emanant de trois societes ont donne lieu a la signature de contrats. Il s'agit de: a) la Societa Elettronucleare Nazionale (SENN) qui fait construire en Italie une centrale de 150 MW(e) nets equipee d'un reacteur a eau bouillante a double cycle; b) la Societa Italiana Meridionale Energia Atomica (SIMEA) qui a entrepris en Italie la construction d'une centrale de 200 MW(e) nets equipee d'un reacteur du type uranium naturel-graphite-gaz carbonique; c) la Societe d'Energie Nucleaire Franco-Belge des Ardennes (SENA) qui a entrepris a la frontiere franco-belge la construction d'une centrale equipee d'un reacteur a eau pressurisee d'une puissance qui pourra atteindre et probablement depasser 242 MW(e) nets. En outre, la Commission a e te saisie de demandes de participation a deux autres reacteurs de puissance presentees respectivement par le Groupement Rheinisch-Westfalisches Elektiizitatswerk-Bayernwerke (RWE-BW), et par la N.V. Samenwerkende Electriciteits-Productiebedrijve; la premiere pour un reacteur de 237 MW(e) a eau bouillante a double cycle, la seconde pour un reacteur de 50 MW(e) a eau bouillante a simple cyc le et circulation naturelle. La participation communautaire peut prendre des formes diverses. Elle peut en particulier prendre celle d'une participation au deficit eventuel de la production d'electricite des centrales pendant les premieres
The reprocessing of irradiated fuels by halides and their compounds; Le traitement des combustibles irradies par les halogenes et leurs composes

Energy Technology Data Exchange (ETDEWEB)

Bourgeois, M; Faugeras, P [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

1964-07-01

A brief description is given of the experiments leading to the choice of the process volatilization of fluorides by gas phase attack. The chemical process is described for certain current types of clad Fuels: the aluminium or the zirconium cladding is first volatilized as chloride by attack with gaseous hydrogen chloride. The uranium is then transformed into volatile hexafluoride by attack with fluorine. These reactions are carried out consecutively in the same reactor in the presence of a fluidized bed of alumina which facilitates heat exchange. The experiments have been carried out in quantities from 100 gms to several kilograms of fuel, first without activity, and then with tracers. A description is given of the laboratory research which was carried out simultaneously on the separation of uranium and plutonium fluorides. Finally, an apparatus is described which is intended to test the process on irradiated fuel at an activity level of several thousands of curies of fission products. (authors) [French] On rappelle brievement les experimentations qui nous ont permis de decider du procede adopte volatilisation des fluorures par attaque en phase gazeuse. On decrit le processus chimique pour certains types courants de combustibles Gaines: dans un premier stade, l'aluminium ou le zirconium est volatilise sous forme de chlorure par action de l'acide chlorhydrique. Ensuite, l'uranium est transforme en hexafluorure volatil par action du fluor. Ces operations se font successivement dans un meme reacteur, en presence d'un lit fluidise d'alumine qui a pour but de faciliter les echanges thermiques. L'experimentation a ete conduite sur des quantites allant de 100 g a plusieurs kg de combustibles, en inactif, puis avec des traceurs. On decrit les etudes de laboratoire menees parallelement sur la separation des fluorures d'uranium et de plutonium. Enfin, on decrit une installation en construction destinee a experimenter le procede sur combustible irradie, a l'echelle de
FooPar

DEFF Research Database (Denmark)

Hargreaves, F. P.; Merkle, D.

2013-01-01

We present FooPar, an extension for highly efficient Parallel Computing in the multi-paradigm programming language Scala. Scala offers concise and clean syntax and integrates functional programming features. Our framework FooPar combines these features with parallel computing techniques. Foo......, results based on a empirical analysis on two supercomputers are given. We achieve close-to-optimal performance wrt. theoretical peak performance. Based on this result we conclude that FooPar allows programmers to fully access Scalas design features without suffering from performance drops when compared...
Phosphorylation of Mycobacterium tuberculosis ParB participates in regulating the ParABS chromosome segregation system.

Science.gov (United States)

Baronian, Grégory; Ginda, Katarzyna; Berry, Laurence; Cohen-Gonsaud, Martin; Zakrzewska-Czerwińska, Jolanta; Jakimowicz, Dagmara; Molle, Virginie

2015-01-01

Here, we present for the first time that Mycobacterium tuberculosis ParB is phosphorylated by several mycobacterial Ser/Thr protein kinases in vitro. ParB and ParA are the key components of bacterial chromosome segregation apparatus. ParB is a cytosolic conserved protein that binds specifically to centromere-like DNA parS sequences and interacts with ParA, a weak ATPase required for its proper localization. Mass spectrometry identified the presence of ten phosphate groups, thus indicating that ParB is phosphorylated on eight threonines, Thr32, Thr41, Thr53, Thr110, Thr195, and Thr254, Thr300, Thr303 as well as on two serines, Ser5 and Ser239. The phosphorylation sites were further substituted either by alanine to prevent phosphorylation or aspartate to mimic constitutive phosphorylation. Electrophoretic mobility shift assays revealed a drastic inhibition of DNA-binding by ParB phosphomimetic mutant compared to wild type. In addition, bacterial two-hybrid experiments showed a loss of ParA-ParB interaction with the phosphomimetic mutant, indicating that phosphorylation is regulating the recruitment of the partitioning complex. Moreover, fluorescence microscopy experiments performed in the surrogate Mycobacterium smegmatis ΔparB strain revealed that in contrast to wild type Mtb ParB, which formed subpolar foci similar to M. smegmatis ParB, phoshomimetic Mtb ParB was delocalized. Thus, our findings highlight a novel regulatory role of the different isoforms of ParB representing a molecular switch in localization and functioning of partitioning protein in Mycobacterium tuberculosis.
Phosphorylation of Mycobacterium tuberculosis ParB participates in regulating the ParABS chromosome segregation system.

Directory of Open Access Journals (Sweden)

Grégory Baronian

Full Text Available Here, we present for the first time that Mycobacterium tuberculosis ParB is phosphorylated by several mycobacterial Ser/Thr protein kinases in vitro. ParB and ParA are the key components of bacterial chromosome segregation apparatus. ParB is a cytosolic conserved protein that binds specifically to centromere-like DNA parS sequences and interacts with ParA, a weak ATPase required for its proper localization. Mass spectrometry identified the presence of ten phosphate groups, thus indicating that ParB is phosphorylated on eight threonines, Thr32, Thr41, Thr53, Thr110, Thr195, and Thr254, Thr300, Thr303 as well as on two serines, Ser5 and Ser239. The phosphorylation sites were further substituted either by alanine to prevent phosphorylation or aspartate to mimic constitutive phosphorylation. Electrophoretic mobility shift assays revealed a drastic inhibition of DNA-binding by ParB phosphomimetic mutant compared to wild type. In addition, bacterial two-hybrid experiments showed a loss of ParA-ParB interaction with the phosphomimetic mutant, indicating that phosphorylation is regulating the recruitment of the partitioning complex. Moreover, fluorescence microscopy experiments performed in the surrogate Mycobacterium smegmatis ΔparB strain revealed that in contrast to wild type Mtb ParB, which formed subpolar foci similar to M. smegmatis ParB, phoshomimetic Mtb ParB was delocalized. Thus, our findings highlight a novel regulatory role of the different isoforms of ParB representing a molecular switch in localization and functioning of partitioning protein in Mycobacterium tuberculosis.
Mechanism of the extraction of nitric acid and water by organic solutions of tertiary alkyl-amines; Mecanisme d'extraction de l'acide nitrique et de l'eau par les solutions organiques d'alcoylamines tertiaires

Energy Technology Data Exchange (ETDEWEB)

Gourisse, D

1966-06-01

The micellar aggregation of tri-alkyl-ammonium nitrates in low polarity organic solvents has been verified by viscosity, conductivity and sedimentation velocity measurements. The aggregation depends upon the polarity of solvent, the length of the alkyl radicals and the organic concentration of the various constituents (tri-alkyl-ammonium nitrate, tri-alkyl-amine, nitric acid, water). The amine salification law has been established and the excess nitric acid and water solubilities in the organic solutions have been measured. Nitric acid and water are slightly more soluble in micellar organic solutions than in molecular organic solutions. A description of excess nitric acid containing tri-alkyl-ammonium nitrate solutions is proposed. (author) [French] Mecanisme d'extraction de l'acide nitrique et de l'eau par les solutions organiques d'alcoylamines tertiaires. L'agregation micellaire des nitrates de trialcoylammonium dans les solvants peu polaires a ete verifiee par viscosimetrie, conductimetrie et ultracentrifugation des solutions organiques. L'agregation depend de la polarite du solvant, de la longueur des radicaux alcoyle, et des concentrations des differents constituants de la solution organique (nitrate de trialcoylammonium, alcoylamine tertiaire, acide nitrique, eau). La loi de salification de l'amine a ete determinee et les solubilites de l'acide nitrique en exces et de l'eau dans les solutions organiques ont ete mesurees. L'acide nitrique et l'eau sont legerement plus solubles dans les organiques micellaires que dans les solutions organiques moleculaires. Une description des solutions de nitrate de trialcoylammonium contenant de l'acide nitrique en exces est proposee. (auteur)
Description of the Triton reactor; Pile Triton, rapport descriptif

Energy Technology Data Exchange (ETDEWEB)

NONE

1967-09-01

The Triton reactor is an enriched uranium pool type reactor. It began operation in 1959, after a divergence made on the June 30 the same year. Devoted to studies of radiation protection, its core can be displaced in the longitudinal direction. The pool can be separated in two unequal compartments by a wall. The Triton core is placed in a small compartment, the Nereide core in the big compartment. A third compartment without water is called Naiade II, is separated by a concrete wall in which is made a window closed by an aluminium plate (2.50 m x 2.70 m). The Naiade II hole is useful for protection experiments using the Nereide core. After a complete refitting, the power of the triton reactor that reached progressively from 1.2 MW to 2 MW, then 3 MW has reached in August 1965 6.5 MW. The reactor has been specialized in irradiations in fix position, the core become fix, the nereide core has been hung mobile. Since it has been used for structure materials irradiation, for radioelements fabrication and fundamental research. The following descriptions are valid for the period after August 1965. [French] Le reacteur Triton est un reacteur piscine, a uranium enrichi. Il est entre en fonctionnement en 1959, apres une divergence effectuee le 30 juin de cette meme annee. Destine a des etudes de protection contre les rayonnements, son coeur pouvait se deplacer dans le sens longitudinal. La piscine peut etre separee en deux compartiments inegaux par un batardeau. Le coeur triton est place dans le petit compartiment, le coeur Nereide dans le grand compartiment. Un troisieme compartiment sans eau, appele Naiade II, est separe par une paroi en beton dans laquelle est amenagee une fenetre obturee par une plaque d'aluminium (2,50 m x 2,70 m). La fosse Naiade II sert a des experiences de protection utilisant le coeur nereide. Apres une refonte complete, la puissance du reacteur triton qui etait passee progressivement de 1,2 MW a 2 MW, puis 3 MW, a atteint en aout 1965 6, 5 MW. Le
Testing of a reactimeter for a light water reactor in the range + 500 to - 5000 pcm; Essai d'un reactimetre pour reacteur a eau legere dans la gamme + 500, - 5000 pcm

Energy Technology Data Exchange (ETDEWEB)

Chauvet, G [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1964-07-01

This apparatus is designed to measure instantaneously the positive or negative reactivity of a uranium reactor moderated by light water, on condition that the point of departure is the critical state of the reactor, or an already known sub-critical state. Slight modifications only are required to adapt it to another type of reactor. It is an analogue computer which simply inverses the transfer function of the reactor; it is not therefore a model reactor of which the output voltage is connected by a servo-mechanism to the power of the reactor to give the reactivity; the principle of the calculation of the reactivity does not depend on a servomechanism. One of its disadvantages is that it cannot operate outside a power variation range of 2.5 decades. However the measurement of a negative reactivity value between 0 and 3000 pcm is immediate. It measures the reactivity without deducting it from the period; it therefore gives the reactivity very precisely both for divergence and convergence even through in this latter case the period does not in fact exist. The equipment makes it possible to calibrate very rapidly the control rods of a reactor (the rod-drop method), to measure the reactivity of an experiment in the core, and to measure certain temperature effects. It is also possible by introducing a control into the core at a measured rate, to deduce directly its efficiency curve. (author) [French] Cet appareil est destine a mesurer instantanement la reactivite positive ou negative d'un reacteur a uranium modere a l'eau legere, a condition de partir de l'etat critique du reacteur, ou eventuellement d'un etat sous-critique deja connu. De legeres modifications permettent de l'adapter a un autre type de moderateur. C'est un calculateur analogique, qui inverse purement et simplement la fonction de transfert du reacteur; ce n'est donc pas un simulateur de pile dont la tension de sortie est asservie a la puissance du reacteur pour elaborer la reactivite; le principe du

ParA and ParB coordinate chromosome segregation with cell elongation and division during Streptomyces sporulation

Science.gov (United States)

Donczew, Magdalena; Mackiewicz, Paweł; Wróbel, Agnieszka; Flärdh, Klas; Zakrzewska-Czerwińska, Jolanta

2016-01-01

In unicellular bacteria, the ParA and ParB proteins segregate chromosomes and coordinate this process with cell division and chromosome replication. During sporulation of mycelial Streptomyces, ParA and ParB uniformly distribute multiple chromosomes along the filamentous sporogenic hyphal compartment, which then differentiates into a chain of unigenomic spores. However, chromosome segregation must be coordinated with cell elongation and multiple divisions. Here, we addressed the question of whether ParA and ParB are involved in the synchronization of cell-cycle processes during sporulation in Streptomyces. To answer this question, we used time-lapse microscopy, which allows the monitoring of growth and division of single sporogenic hyphae. We showed that sporogenic hyphae stop extending at the time of ParA accumulation and Z-ring formation. We demonstrated that both ParA and ParB affect the rate of hyphal extension. Additionally, we showed that ParA promotes the formation of massive nucleoprotein complexes by ParB. We also showed that FtsZ ring assembly is affected by the ParB protein and/or unsegregated DNA. Our results indicate the existence of a checkpoint between the extension and septation of sporogenic hyphae that involves the ParA and ParB proteins. PMID:27248800
Automation of nonlinear calculations in the theory of fusion reactor; Automatisation des calculs non lineaires dans la theorie des reacteurs a fusion

Energy Technology Data Exchange (ETDEWEB)

Braffort, P; Chaigne, M [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1958-07-01

dans le cas stationnaire et l'on compare avec les resultats de l'experience. 4) On decrit la resolution analogique du probleme dynamique de l'evolution du courant de decharge dans un cas simple et l'on compare avec les resultats de l'experience. 5) On decrit la resolution analogique du mouvement des ions isoles dans un champ electromagnetique et l'on decrit le simulateur de champ spatial utilise dans ce probleme (probleme bidimensionnel). 6) On decrit la resolution analogique du probleme precedent dans le cas tridimensionnel pour des geometries particulieres (notamment toroidale) grace a l'emploi simultane de deux simulateurs de champ. 7) On decrit une methode de calcul derivee de la methode de Monte-Carlo, susceptible de s'adapter a l'etude de la dynamique des plasmas et l'on decrit le materiel de commutation-memorisation utilise. 8) Conclusion: On indique la difference profonde que presentent les calculs analogiques pour l'etude des reacteurs a fission et a fusion. On discute notamment la theorie du controle presentee par SCHULTZ en comparant les resultats du calcul linearise a ceux de la simulation non lineaire. (auteur)
Par Pond water balance

International Nuclear Information System (INIS)

Hiergesell, R.A.; Dixon, K.L.

1996-06-01

A water budget for the Par Pond hydrologic system was established in order to estimate the rate of groundwater influx to Par Pond. This estimate will be used in modeling exercises to predict Par Pond reservoir elevation and spillway discharge in the scenario where Savannah River water is no longer pumped and discharged into Par Pond. The principal of conservation of mass was used to develop the water budget, where water inflow was set equal to water outflow. Components of the water budget were identified, and the flux associated with each was determined. The water budget was considered balanced when inflow and outflow summed to zero. The results of this study suggest that Par Pond gains water from the groundwater system in the upper reaches of the reservoir, but looses water to the groundwater system near the dam. The rate of flux of groundwater from the water table aquifer into Par Pond was determined to be 13 cfs. The rate of flux from Par Pond to the water table aquifer near the dam was determined to be 7 cfs
Safety report concerning the reactor Pegase - volume 1 - Description of the installation - volume 2 - Safety of the installations; Rapport de surete du reacteur pegase - tome 1 - Description des installations - tome 2 - Surete des installations

Energy Technology Data Exchange (ETDEWEB)

Lacour, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Legoin, P. [S.E.M. Hispano-Suiza, 92 - Colombes (France)

1964-07-01

In the first volume: This report is a description of the reactor Pegase, given with a view to examine the safety of the installations. The Cadarache site at which they are situated is briefly described, in particular because of the consequences on the techniques employed for building Pegase. A description is also given of the original aspects of the reactor. The independent loops which are designed for full-scale testing of fuel elements used in natural uranium-gas-graphite reactor systems are described in this report, together with their operational and control equipment. In the second volume: In the present report are examined the accidents which could cause damage to the Pegase reactor installation. Among possible causes of accidents considered are the seismicity of the region, an excessive power excursion of the reactor and a fracture in the sealing of an independent loop. Although all possible precautions have been taken to offset the effects of such accidents, their ultimate consequences are considered here. The importance is stressed of the security action and regulations which, added to the precautions taken for the construction, ensure the safety of the installations. (authors) [French] Dans le volume 1: Ce rapport est une description du reacteur Pegase, afin d'examiner la surete des installations. Le site de CADARACHE ou elles sont situees, a ete sommairement decrit, en particulier, a cause des consequences sur les techniques mises en oeuvre pour la realisation de Pegase. Nous nous sommes egalement attache a decrire les aspects originaux du reacteur. Les boucles autonomes destinees a tester en vraie grandeur des elements combustibles de la filiere uranium naturel graphite-gaz, ainsi que leurs dispositifs de controle et d'exploitation, figurent egalement dans ce rapport. Dans le volume 2: Dans le present rapport, nous examinons des accidents pouvant endommager des installations du reacteur Pegase. Les origines d'accidents examines
Safety report concerning the reactor Pegase - volume 1 - Description of the installation - volume 2 - Safety of the installations; Rapport de surete du reacteur pegase - tome 1 - Description des installations - tome 2 - Surete des installations

Energy Technology Data Exchange (ETDEWEB)

Lacour, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Legoin, P [S.E.M. Hispano-Suiza, 92 - Colombes (France)

1964-07-01

In the first volume: This report is a description of the reactor Pegase, given with a view to examine the safety of the installations. The Cadarache site at which they are situated is briefly described, in particular because of the consequences on the techniques employed for building Pegase. A description is also given of the original aspects of the reactor. The independent loops which are designed for full-scale testing of fuel elements used in natural uranium-gas-graphite reactor systems are described in this report, together with their operational and control equipment. In the second volume: In the present report are examined the accidents which could cause damage to the Pegase reactor installation. Among possible causes of accidents considered are the seismicity of the region, an excessive power excursion of the reactor and a fracture in the sealing of an independent loop. Although all possible precautions have been taken to offset the effects of such accidents, their ultimate consequences are considered here. The importance is stressed of the security action and regulations which, added to the precautions taken for the construction, ensure the safety of the installations. (authors) [French] Dans le volume 1: Ce rapport est une description du reacteur Pegase, afin d'examiner la surete des installations. Le site de CADARACHE ou elles sont situees, a ete sommairement decrit, en particulier, a cause des consequences sur les techniques mises en oeuvre pour la realisation de Pegase. Nous nous sommes egalement attache a decrire les aspects originaux du reacteur. Les boucles autonomes destinees a tester en vraie grandeur des elements combustibles de la filiere uranium naturel graphite-gaz, ainsi que leurs dispositifs de controle et d'exploitation, figurent egalement dans ce rapport. Dans le volume 2: Dans le present rapport, nous examinons des accidents pouvant endommager des installations du reacteur Pegase. Les origines d'accidents examines comprennent la seismicite
The behaviour of some polyatomic gases in nuclear reactors; Le comportement de quelques gaz polyatomiques dans les reacteurs nucleaires

Energy Technology Data Exchange (ETDEWEB)

Dolle, L [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1958-07-01

The chemical effect of ionizing radiations on a certain number of gaseous systems is described. Under the influence of radiations from a reactor, NH{sub 3}, is decomposed to nitrogen and hydrogen in stoichiometric proportions. Formation of N{sub 2}H{sub 3}, particularly could not be detected. Under a slow neutron flux the reaction {sup 14}N (n, p) {sup 14}C constitutes the main source of decomposition energy. Direct recombination of H, and N, has been brought about under the influence of radiation. The radiolysis of NH{sub 3}, occurs by a complex mechanism; and the kinetics follow a law of the order of about 2.5 which increases with the decomposition rate. The decomposition of hydrogen sulphide is appreciably faster than that of NH{sub 3}. Hydrogen is the only gaseous product of the reaction. The sulphur, which is deposited on the walls of the ampoules, is clearly visible to the naked eye. Up to the present decompositions up to 84 per cent have been obtained. The influence of the reaction {sup 32}S (n, p) {sup 32}P is considered. Radiochemical decomposition of nitrous oxide N{sub 2}O takes place with high yields. The reaction is complicated from the beginning by the formation of higher oxides of nitrogen which we identify and measure. Radiochemical decomposition of methane gives quantities of higher hydrocarbons. Certain of these gaseous systems could find applications in the measurement of high doses of radiation. This problem is discussed in the conclusion. (author)Fren. [French] L'effet chimique des rayonnements ionisants sur un certain nombre de systemes gazeux est decrit. Sous l'influence des rayonnements d'un reacteur, NH{sub 3} se decompose en azote et hydrogene en proportions stoechiometriques. En particulier aucune formation de N{sub 2}H{sub 4}, n'a pu etre detectee. Sous flux de neutrons lents, la reaction {sup 14}N (n, p){sup 14}C constitue la principale source d'energie de decomposition. La recombinaison directe de H{sub 2} et N{sub 2} a ete realisous l
Calculation of the working capital invested in fuel cycles and its interest charges (1963); Calcul des immobilisations financieres des cycles de combustible (1963)

Energy Technology Data Exchange (ETDEWEB)

Gaussens, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1963-07-01

All the processes undergone by the nuclear material, including the various steps of fuel element manufacturing and of irradiated fuel reprocessing lead to working capital investments varying with the type of reactor, that must be taken into account in the kWh cost calculation. The author deals with a calculation method called: 'present worth method' and gives some examples concerning reactors the main fuel of which being either natural uranium or enriched uranium or plutonium. He especially points out the importance these investments may take in the case of fast breeder reactors. (author) [French] L'ensemble des etapes parcourues par la matiere fissile comprenant les divers stades d'elaboration des elements combustibles et de leur traitement apres irradiation, implique des immobilisations financieres tres differentes d'un type de reacteur a l'autre, dont il convient de tenir compte dans le calcul du cout du kWh. L'auteur expose une methode de calcul dite 'd'actualisation des couts' et donne quelques exemples relatifs aux reacteurs utilisant l'uranium naturel, l'uranium enrichi et le plutonium comme combustible principal. Il montre en particulier l'importance que peuvent avoir ces immobilisations dans le cas des reacteurs surregenerateurs. (auteur)
suPAR

DEFF Research Database (Denmark)

Hodges, Gethin W; Bang, Casper N; Wachtell, Kristian

2015-01-01

The fundamental role of inflammation in cardiovascular disease (CVD) has prompted interest in numerous biomarkers that detect subclinical levels of inflammation. Soluble urokinase plasminogen activator receptor (suPAR) is a novel biomarker that correlates significantly with cardiovascular events ...... comprehensive review of suPAR in CVD and explore its function and usefulness in predicting cardiovascular events....
Measurements with a Pulsed and Modulated Source in a Reactor; Mesures au Moyen d'une Source Pulsee et Modulee dans un Reacteur; Izmereniya v reaktore s pomoshch'yu impul'snogo i moduliruemogo is tochnika; Mediciones Efectuadas en Reactor con una Fuente Pulsada y Modulada

Energy Technology Data Exchange (ETDEWEB)

Rotter, W. [Centre d' Etude de l' Energie Nucleaire, Mol (Belgium)

1965-10-15

a digital computer [French] Un generateur dont le debit neutronique est variable selon une fonction du temps quelconque a ete mis au point par les Laboratoires de recherches Philips. Son utilite pratique dans le domaine de la physique des reacteurs a ete demontree par une serie de mesures effectuees dans le reacteur BRO2 a fotat sous-critique. Sa bonne stabilite, la possibilite de faire varier brusquement l'intensite neutronique, de puiser le debit ou de le moduler sinusoldalement, rend ce generateur tres souple. Il permet de determiner la reactivite ({rho} = {Delta}k/{beta}) et le temps de vie des neutrons ( Script-Small-L /{beta}) d'apres differentes methodes independantes. Une comparaison exacte de ces methodes est possible puisqu'elles peuvent etre employees sans modifier les conditions de mesure. On a determine: a) {rho} sur la base des neutrons retardes, par une reduction instantanee du debit de neutrons; b) {rho} sur la base des neutrons instantanes par des bouffees de neutrons; c) Script-Small-L /{beta} par combinaison de a) et b) pour 0,5 $ < {rho} <2 $; d) Script-Small-L /{beta} sur la base de la fonction de transfert du reacteur pour une source modulee. Les fonctions de transfert pour un oscillateur de reactivite et pour une source modulee sinusoldalement sont discutees. Il est montre que la mesure de Script-Small-L /{beta} est possible pour 0,1 $ < {rho} < 10 $ en utilisant une source modulee. La meme methode fournit aussi la reactivite a l'aide du rapport des neutrons instantanes aux neutrons retardes pour une frequence optimale, pratiquement independamment des donnees relatives aux neutrons retardes et de la valeur de f Script-Small-L /{beta}. Par accumulation d'un grand nombre de cycles dans l'analyseur multicanal, la statistique peut etre amelioree pour chaque methode. Le debit du generateur etant bien sinusoiedal, la reponse du reacteur peut etre integree sur chaque quart d'une periode, etant donne que la chafhe de mesure est pilotee par le
C9.A/14 steelwork joints de poutres par plaque frontale : assemblages par gousset

CERN Document Server

2015-01-01

Les Tables de résistances ultimes des assemblages boulonnés par plaque frontale et par gousset, complétées par une description des modèles de calcul et des exemples d’application, ont pour but de faciliter la tâche de l'ingénieur et du constructeur. Cette première partie C9.A/14 contient les chapitres suivants: - Joints de poutres par plaque frontale en acier S235 et S355 - Assemblages par gousset en acier S235 et S355 Les Tables contiennent des données relatives à la géométrie ainsi que les valeurs de calcul correspondantes des résistances ultimes des assemblages ; elles remplacent le chapitre « Assemblages par plaques frontales et boulons HR » des anciennes Tables C9.1 de 1983 / 2002. Le calcul de ces assemblages par plaque frontale est basé sur les hypothèses du modèle de la méthode des composants décrite dans la norme SN EN 1993-1-8. Les vérifications sont effectuées selon la norme SIA 263:2013. Les assemblages par gousset remplacent les assemblages par double cornière, (telle...
Re-enrichment of depleted uranium by passage through a gaseous diffusion installation; Reenrichissement de l'uranium appauvri par passage dans une installation de diffusion gazeuse

Energy Technology Data Exchange (ETDEWEB)

Lagrange, P; Billous, O [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1958-07-01

The reader will find in this paper an economic study of the re-utilization of depleted uranium from nuclear reactors, whether its content be above or under natural proportions. Re-utilization is possible either through bringing the depleted product up to its initial content of {sup 235}U by mixture with a richer concentrate, or else by passing it through a gaseous diffusion plant. The economic area of such re-utilization depends on a number of considerations. We give a general study of it, with reference to some typical gaseous diffusion facilities. (author)Fren. [French] Ce rapport examine au point de vue economique la reutilisation de l'uranium appauvri provenant des reacteurs nucleaires, qu'il soit indifferemment en dessus ou en dessous de la teneur naturelle. Cette reutilisation peut se faire soit en ramenant le produit a sa teneur initiale en isotope 235 par un melange convenable avec un concentre plus riche, soit en le faisant passer dans une usine de Diffusion Gazeuse. La zone de rentabilite de cette reutilisation depend de diverses conditions economiques. Elle est etudiee ci-dessous d'une maniere generale, puis en se referant a des installations-type de diffusion gazeuse. (auteur)
Fabrication of the 4. set of fuel elements for the experimental pile EL2; Fabrication du 4. jeu de barreaux de la pile d'essai EL2

Energy Technology Data Exchange (ETDEWEB)

Ringot, C [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1958-07-01

The reactor EL2 is the second atomic reactor built in France. It is a laboratory reactor using heavy water and natural uranium. Its cooling circuit operates with compressed CO{sub 2} gas at 8 kg/cm{sup 2} pressure. The subject of this lecture is the manufacturing of the fourth set of rods. The principle of uranium-can connection is exposed: that is the principle of a pre-pressed bound can. The EL2 reactor has been a prototype with respect to this aspect of the question, and a prototype which has been quite satisfactory. The main steps of the fabrication are exposed: the {gamma} phase extension of uranium, the machining, the three canning (die canning, hydraulic canning, compressed air treatment), the automatic argon arc welding of cups and the different manufacturing controls. (author) [French] Le reacteur EL2 est le deuxieme reacteur construit en France. C'est un reacteur de recherches qui utilise de l'eau lourde et de l'uranium naturel. Il est refroidi par du gaz carbonique sous 8 kg/cm{sup 2} de pression. On etudie dans cet expose la fabrication du quatrieme jeu d'elements combustibles. Le principe de la liaison uranium-gaine est expose: c'est celui d'une gaine precontrainte. La pile EL2 a constitue un prototype a ce point de vue, prototype qui a donne entiere satisfaction. Les principales etapes de la fabrication sont ensuite expliquees: le filage {gamma} de l'uranium, l'usinage des barreaux, les trois operations de gainages (gainage par filiere, gainage hydraulique, gainage a chaud), la soudure automatique des bouchons a l'argon-arc et les differents controles de fabrication. (auteur)
Contribution to the determination of Sb-Ag-Cu-Ga-Mo-Zn using 14 MeV neutron activation; Contribution au dosage de Sb-Ag-Cu-Ga-Mo-Zn par activation aux neutrons de 14 MeV

Energy Technology Data Exchange (ETDEWEB)

Crambes, M [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1966-04-01

By using, 14 MeV, neutron irradiation it is possible to extend the field of application of neutron radio-activation analysis, in particular to the case of light elements. For, many other elements it can replace in-pile irradiation thereby making it possible, thanks to portable 14 MeV neutron generators, to carry out radio-activation analyses away from nuclear-research c e n t r e s. With a view to applying this analytical technique to routine work, we have developed some rapid chemical separation methods in order to make possible the determination of several elements which after exposure to fast neutrons, produce {beta} emitting nuclides which cannot be differentiated by a simple instrumental study, the emitted radiation being of the same type and of similar half-life the two cases. (author) [French] L'irradiation au moyen de neutrons de 14 MeV permet d'etendre le domaine d'application de l'analyse par radioactivation neutronique, en particulier aux elements legers. Cependant pour de nombreux autres elements elle peut remplacer l'irradiation en reacteur nucleaire permettant ainsi grace aux ensembles portables producteurs de neutrons de 14 MeV, l'extension de l'analyse par radioactivation a l'exterieur des centres d'etudes nucleaires. Dans le but d'appliquer cette methode d'analyse a des travaux de routine, nous avons mis au point des separations chimiques rapides, afin de permettre le dosage de quelques elements qui par irradiation aux neutrons rapides, engendrent des nucleides emetteurs {beta} qu'une simple etude instrumentale ne peut differencier en raison de l'identite de leur rayonnement et de leurs periodes radioactives trop proches. (auteur)
Preparation of high critical temperature YBa{sub 2}Cu{sub 3}O{sub 7} superconducting coatings by thermal spray; Elaboration par projection a chaud de revetements supraconducteurs a haute temperature critique de type YBa{sub 2}Cu{sub 3}O{sub 7}

Energy Technology Data Exchange (ETDEWEB)

Lacombe, Jacques

1991-09-20

The objective of this research thesis is the elaboration of YBa{sub 2}Cu{sub 3}O{sub 7} superconducting coatings by thermal spray. These coatings must have a high adherence, a high cohesion, and the best possible electrical characteristics. The author first briefly presents physical-chemical characteristics of this ceramic, and proposes a bibliographical synthesis on thick coatings prepared by thermal spray. In the next parts, he studies and describes conditions of elaboration of poly-granular coatings of YBa{sub 2}Cu{sub 3}O{sub 7}, and their structural and electric characteristics [French] Des revetements epais de YBa{sub 2}Cu{sub 3}O{sub 7} ont ete elabores par projection a chaud sur des substrats d'acier inoxydable revetus d'une sous-couche de Ni-Cr-Al-Y. Les principales etapes du processus de fabrication sont les suivantes: - preparation de la poudre par voie humide selon un procede mis au point au C.E.R.E.M., - realisation des revetements epais par projection a chaud de cette poudre selon trois differentes techniques: projection plasma atmospherique, projection plasma sous pression reduite, projection flamme oxyacetylenique. - traitement thermique en deux etapes des revetements pour recristalliser la phase YBa{sub 2}Cu{sub 3}O{sub 7} et la reoxygener (traitement thermique dans un four sous oxygene). Les depots elabores selon cette voie sont adherents et homogenes a la fois en composition et en morphologie. La phase supraconductrice YBa{sub 2}Cu{sub 3}O{sub 7} determinee par diffraction de rayons X est bien cristallisee; elle se presente sous forme de plaquettes d'environ 10 μm de long et 1 μm d'epaisseur sans orientation preferentielle. Les revetements realises par projection plasma atmospherique presentent les meilleures caracteristiques electriques: Tc(R=0) = 90.5K; ΔTc = 1K; ρ (300 K) = 0.7 - 0.8 mΩ.cm; Jc(77 K,0 T) = 1000 A/cm{sup 2}. Les proprietes d'ecrantage magnetique ont ete comparees a celles de materiaux utilises pour le blindage magnetique
Parálisis cerebral :

OpenAIRE

Cabrero Izquierdo, María del Carmen

2012-01-01

Se aborda el tema de la parálisis cerebral definiendo qué es, clasificando los tipos de parálisis dependiendo de la afectación y las características principales. Se explican algunos de sus tratamientos, se dan sistemas alternativos y/o aumentativos de comunicación para un alumno con PC (parálisis cerebral).
Contribution to the study of nuclear fuel materials with a metallic uranium base; Contribution a l'etude des materiaux combustibles nucleaires a base d'uranium metallique

Energy Technology Data Exchange (ETDEWEB)

Englander, M [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1957-11-15

In a power reactor destined to supply industrially recoverable thermal energy, the most economical source of heat still consists of natural metallic uranium. However, the nuclear fuel material, most often employed in the form of rods of 20 to 40 mm diameter, is subjected to a series of stresses which lead to irreversible distortions usually incompatible with the substructure of the reactor. As a result the fuel material must possess at the outset a certain number of qualities which must be determined. Investigations have therefore been carried out, first on the technological characters peculiar to each of the three allotropic phases of pure uranium metal, and on their interactions on the stabilisation of the material which consists of either cast uranium or uranium pile-treated in the {gamma} phase. (author) [French] Dans un reacteur de puissance destine a fournir de l'energie thermique industriellement recuperable, la source de chaleur la plus economique reste constituee par de l'uranium metallique naturel. Or, le materiau combustible nucleaire, employe le plus souvent sous forme de barreaux de 20 a 40 mm de diametre, se trouve soumis a un ensemble de contraintes qui provoque des deformations irreversibles, le plus souvent incompatibles avec l'infrastructure du reacteur. Par consequent, le materiau combustible doit presenter a l'origine un certain nombre de qualites qu'il est necessaire de determiner. Aussi a-t-on d'abord etudie les caracteres technologiques propres a chacune des trois phases allotropiques de l'uranium-metal pur et leurs interactions sur la stabilisation du materiau constitue soit par de l'uranium coule, soit par de l'uranium traite en pile en phase {gamma}. (auteur)
Development of a power-period calculation unit for nuclear reactor Control; Etude et realisation d'un ensemble de calcul puissance periode pour le controle d'un reacteur nucleaire

Energy Technology Data Exchange (ETDEWEB)

Martin, J [Commissariat a l' Energie Atomique, Centre d' Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette (France)

1966-10-01

The apparatus studied is a digital calculating assembly which makes it possible to prepare and to present numerically the period and power of a nuclear reactor during operation, from start-up to nominal power. The pulses from a fission chamber are analyzed continuously, using real time. A small number of elements is required because of the systematic use of a calculation technique comprising the determination of a base 2 logarithm by a linear approximation. The accuracy obtained for the period is of the order of 14%; the response time of the order of the calculated period value. An approximate value of the power (30%) is given at each calculation cycle together with the power thresholds required for the control. (author) [French] L'appareil etudie est un ensemble de calcul digital permettant d'elaborer et d'afficher numeriquement la periode et la puissance, d'un reacteur nucleaire lors de son fonctionnement depuis le demarrage jusqu'a la puissance nominale. Il traite en temps reel, de facon continue, les impulsions en provenance d'une chambre de fission. Grace a l'utilisation systematique d'une technique de calcul, la determination d'un logarithme a base 2 par approximation lineaire, un nombre reduit d'elements est utilise. La precision obtenue sur la periode est de l'ordre de 14 pour cent, le temps de reponse de l'ordre de la valeur de la periode calculee. Un ordre de grandeur de la puissance (30 pour cent) est donne a chaque cycle de calcul ainsi que des seuils de puissance necessaires au controle. (auteur)
Extraction of beryllium sulfate by a long chain amine; Extraction du sulfate de beryllium par une amine a longue chaine

Energy Technology Data Exchange (ETDEWEB)

Etaix, E.S. [Commissariat a l' Energie Atomique, Fontenay-Aux-Roses (France). Centre d' Etudes Nucleaires

1968-06-01

The extraction of sulfuric acid in aqueous solution by a primary amine in benzene solution, 3-9 (diethyl) - 6-amino tri-decane (D.E.T. ) - i.e., with American nomenclature 1-3 (ethyl-pentyl) - 4-ethyl-octyl amine (E.P.O.) - has made it possible to calculate the formation constants of alkyl-ammonium sulfate and acid sulfate. The formula of the beryllium and alkyl-ammonium sulfate complex formed in benzene has next been determined, for various initial acidity of the aqueous solution. Lastly, evidence has been given of negatively charged complexes of beryllium and sulfate in aqueous solution, through the dependence of the aqueous sulfate ions concentration upon beryllium extraction. The formation constant of these anionic complexes has been evaluated. (author) [French] L'etude de l'extraction de l'acide sulfurique en solution aqueuse par une amine primaire en solution dans le benzene, le diethyl-3,9 amino-6 tridecane (D.E.T.) - autre nom americain 1-3 (ethylpentyl) - 4-ethyloctylamine (E.P.O.) a permis de calculer les constantes de formation du sulfate et de l'hydrogenosulfate d'alkyl-ammonium. La formule du complexe de sulfate de beryllium et d'alkyl-ammonium forme en solution benzenique a ete ensuite determinee pour diverses acidites initiales de la solution aqueuse. Enfin, l'influence de la concentration des ions sulfate de la phase aqueuse sur l'extraction du beryllium a mis en evidence la formation en solution aqueuse de complexes anioniques de sulfate et de beryllium dont la constante de formation a ete evaluee. (auteur)
Extraction of beryllium sulfate by a long chain amine; Extraction du sulfate de beryllium par une amine a longue chaine

Energy Technology Data Exchange (ETDEWEB)

Etaix, E S [Commissariat a l' Energie Atomique, Fontenay-Aux-Roses (France). Centre d' Etudes Nucleaires

1968-06-01

The extraction of sulfuric acid in aqueous solution by a primary amine in benzene solution, 3-9 (diethyl) - 6-amino tri-decane (D.E.T. ) - i.e., with American nomenclature 1-3 (ethyl-pentyl) - 4-ethyl-octyl amine (E.P.O.) - has made it possible to calculate the formation constants of alkyl-ammonium sulfate and acid sulfate. The formula of the beryllium and alkyl-ammonium sulfate complex formed in benzene has next been determined, for various initial acidity of the aqueous solution. Lastly, evidence has been given of negatively charged complexes of beryllium and sulfate in aqueous solution, through the dependence of the aqueous sulfate ions concentration upon beryllium extraction. The formation constant of these anionic complexes has been evaluated. (author) [French] L'etude de l'extraction de l'acide sulfurique en solution aqueuse par une amine primaire en solution dans le benzene, le diethyl-3,9 amino-6 tridecane (D.E.T.) - autre nom americain 1-3 (ethylpentyl) - 4-ethyloctylamine (E.P.O.) a permis de calculer les constantes de formation du sulfate et de l'hydrogenosulfate d'alkyl-ammonium. La formule du complexe de sulfate de beryllium et d'alkyl-ammonium forme en solution benzenique a ete ensuite determinee pour diverses acidites initiales de la solution aqueuse. Enfin, l'influence de la concentration des ions sulfate de la phase aqueuse sur l'extraction du beryllium a mis en evidence la formation en solution aqueuse de complexes anioniques de sulfate et de beryllium dont la constante de formation a ete evaluee. (auteur)
Two further years of operation of the reactor G1 (july 1958 - july 1960); Deux nouvelles annees de fonctionnement du reacteur G1. (juillet 1958 - Juillet 1960)

Energy Technology Data Exchange (ETDEWEB)

Mathot, P; Bauzit, J; Cante, R; Hebrard, L [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

1960-07-01

The aim of the present report is to present certain observations and to give the results obtained during the period from july the 1{sup st} 1958 to july the 1{sup st} 1960. The main operations carried out during this period were, chronologically: - From july the 5{sup th} to october the 18{sup th} 1958: preparation and execution of the first annealing of the graphite. - From dec. the 15{sup th} 1958 to july the 15{sup th} 1959: a discharging campaign which resulted in the complete renewal of the fuel elements. During the monthly stoppages of this campaign, it was possible to make certain observations concerning the packing of the graphite, while at the same time measurements of the temperature of the element cans were made at an increased number of points. - From september the 25{sup th} 1959 to december the 9{sup th} 1959: preparation and execution of the second annealing. At the end of the annealing, the thorium lattice was modified and extra thermocouples were installed for measuring the temperature of the body of the graphite. An apparatus was built for measuring the radial flux. - From december the 9{sup th} 1959 to july 1960: a continuous operation campaign, with a minimum of stoppages. The experimental results are re-assembled, independently of their chronological order, under three main headings which describe the reactors history: - continuous operation, - discharges, - annealing of the reactor. (author) [French] Le but du present rapport est d'exposer certaines observations faites et les resultats obtenus au cours de la periode du 1{sup er} juillet 1958 au 1{sup er} juillet 1960. Cette periode a ete marquee chronologiquement par les operations essentielles suivantes: - du 5 juillet au 18 octobre 1958: preparation et execution du premier recuit du graphite. - du 15 decembre 1958 au 15 juillet 1959: campagne de dechargement entrainant un renouvellement total des cartouches de combustibles. Au cours des arrets mensuels de cette campagne, certaines

Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4).

Science.gov (United States)

Cunningham, Margaret R; McIntosh, Kathryn A; Pediani, John D; Robben, Joris; Cooke, Alexandra E; Nilsson, Mary; Gould, Gwyn W; Mundell, Stuart; Milligan, Graeme; Plevin, Robin

2012-05-11

Proteinase-activated receptors 4 (PAR(4)) is a class A G protein-coupled receptor (GPCR) recognized through the ability of serine proteases such as thrombin and trypsin to mediate receptor activation. Due to the irreversible nature of activation, a fresh supply of receptor is required to be mobilized to the cell surface for responsiveness to agonist to be sustained. Unlike other PAR subtypes, the mechanisms regulating receptor trafficking of PAR(4) remain unknown. Here, we report novel features of the intracellular trafficking of PAR(4) to the plasma membrane. PAR(4) was poorly expressed at the plasma membrane and largely retained in the endoplasmic reticulum (ER) in a complex with the COPI protein subunit β-COP1. Analysis of the PAR(4) protein sequence identified an arginine-based (RXR) ER retention sequence located within intracellular loop-2 (R(183)AR → A(183)AA), mutation of which allowed efficient membrane delivery of PAR(4). Interestingly, co-expression with PAR(2) facilitated plasma membrane delivery of PAR(4), an effect produced through disruption of β-COP1 binding and facilitation of interaction with the chaperone protein 14-3-3ζ. Intermolecular FRET studies confirmed heterodimerization between PAR(2) and PAR(4). PAR(2) also enhanced glycosylation of PAR(4) and activation of PAR(4) signaling. Our results identify a novel regulatory role for PAR(2) in the anterograde traffic of PAR(4). PAR(2) was shown to both facilitate and abrogate protein interactions with PAR(4), impacting upon receptor localization and cell signal transduction. This work is likely to impact markedly upon the understanding of the receptor pharmacology of PAR(4) in normal physiology and disease.
Description of the Triton reactor; Pile Triton, rapport descriptif

Energy Technology Data Exchange (ETDEWEB)

NONE

1967-09-01

The Triton reactor is an enriched uranium pool type reactor. It began operation in 1959, after a divergence made on the June 30 the same year. Devoted to studies of radiation protection, its core can be displaced in the longitudinal direction. The pool can be separated in two unequal compartments by a wall. The Triton core is placed in a small compartment, the Nereide core in the big compartment. A third compartment without water is called Naiade II, is separated by a concrete wall in which is made a window closed by an aluminium plate (2.50 m x 2.70 m). The Naiade II hole is useful for protection experiments using the Nereide core. After a complete refitting, the power of the triton reactor that reached progressively from 1.2 MW to 2 MW, then 3 MW has reached in August 1965 6.5 MW. The reactor has been specialized in irradiations in fix position, the core become fix, the nereide core has been hung mobile. Since it has been used for structure materials irradiation, for radioelements fabrication and fundamental research. The following descriptions are valid for the period after August 1965. [French] Le reacteur Triton est un reacteur piscine, a uranium enrichi. Il est entre en fonctionnement en 1959, apres une divergence effectuee le 30 juin de cette meme annee. Destine a des etudes de protection contre les rayonnements, son coeur pouvait se deplacer dans le sens longitudinal. La piscine peut etre separee en deux compartiments inegaux par un batardeau. Le coeur triton est place dans le petit compartiment, le coeur Nereide dans le grand compartiment. Un troisieme compartiment sans eau, appele Naiade II, est separe par une paroi en beton dans laquelle est amenagee une fenetre obturee par une plaque d'aluminium (2,50 m x 2,70 m). La fosse Naiade II sert a des experiences de protection utilisant le coeur nereide. Apres une refonte complete, la puissance du reacteur triton qui etait passee progressivement de 1,2 MW a 2 MW, puis 3 MW, a atteint en aout 1965 6, 5 MW
The study by means of a photomultiplier of the scintillations produced by {alpha} particles striking a zinc sulphide screen; Etude, au photomultiplicateur, des scintillations produites par les particules {alpha} dans un ecran de sulfure de zinc. Application a la numeration precise des particules {alpha}

Energy Technology Data Exchange (ETDEWEB)

Anthony, J P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1955-06-15

parcours restant apres traversee d'une epaisseur connue d'air est egalement determinee. Les applications possibles de cette methode de numeration des particules {alpha} sont celles qui necessitent une bonne stabilite et un faible mouvement propre. Les resultats donnes portent sur l'etude de la contamination de l'air, la mesure des variations de la composition isotopique de l'uranium, le dosage du bismuth dans les alliages par irradiation dans un flux de neutrons thermiques et comptage des {alpha} emis par le polonium forme. (auteur)
Radiation hazards in the neighbourhood of uranium reactors; Dangers des rayonnements aupres des piles a uranium

Energy Technology Data Exchange (ETDEWEB)

Joffre, H [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1956-07-01

Radiation hazards near uranium reactors may be divided in two groups. Hazards when the reactor is normally operating: {gamma} radiation from hot uranium or air contamination by fission gases, {gamma} radiation or contamination by the coolant (air, nitrogen, heavy-water), {gamma} radiation from radioisotopes. Hazards in the case of an accident: presence of hot uranium in the atmosphere, soil contamination. (author) [French] Les dangers d'irradiation aupres des piles a uranium sont a classer essentiellement en deux groupes. Les dangers existant aupres d'une pile exploitee normalement: irradiation {gamma} par l'uranium irradie ou contamination de l'air par des gaz de fission, irradiation {gamma} ou contamination par les fluides de refroidissement (air, azote, eau lourde), irradiation {gamma} par les radioelements fabriques. Les dangers en cas d'accident survenant a un reacteur en fonctionnement, ayant pour consequence : la presence dans l'air d'uranium irradie, la contamination du sol. (auteur)
Synthesis of 2-mercaptobenzothiazole ({sup 35}S); Synthese du mercapto-2-benzothiazole ({sup 35}S)

Energy Technology Data Exchange (ETDEWEB)

Bentov, M [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1958-07-01

The synthesis of 2-mercaptobenzothiazole ({sup 35}S) by the interaction of 2-chloro benzothiazole and sodium hydrosulfide ({sup 35}S) has been studied. Under the conditions determined in this study a pure product with a radioactive yield of 79 per cent can be obtained. (author) [French] La synthese du mercapto-2-benzothiazole ({sup 35}S) par l'interaction du chloro-2-benzothiazole et I'hydrosurfure ({sup 35}S) de sodium a ete etudiee. On a trouve que dans les conditions determinees dans cette etude, on peut obtenir un produit pur avec un rendement radioactif de 79 pour cent. (auteur)
The Role of Non-Destructive Testing in the Los Alamos Reactor Programme; Role des Essais Non Destructifs dans le Programme de Reacteurs de los Alamos; Rol' nedestruktivnykh ispytanij materialov v Los-Alamosskoj reaktornoj programme; Papel de los Metodos de Ensayo No Destructivo en el Programa de Reactores de Los Alamos

Energy Technology Data Exchange (ETDEWEB)

Tenney, G. H. [University of California, Los Alamos Scientific Laboratory, Los Alamos, NM (United States)

1965-10-15

the work on this subject has not been previously published. (author) [French] Le Laboratoire scientifique de Los Alamos, exploite par l'Universite de Californie pour la Commission de l'energie atomique des Etats-Unis, s'occupe depuis plus de vingt ans de l'etude, de la mise au point et de la construction de quatre types de reacteurs nucleaires: reacteurs de recherche, reacteurs de puissance, reacteurs pour la propulsion des fusees et assemblages critiques. Le Groupe des essais non destructifs collabore a presque tous les projets et travaux du Laboratoire. Le memoire decrit quelques-unes des methodes inedites d'essais non destructifs qui y ont ete mises au point et sont appliquees dans le cadre du programme de reacteurs. Le reacteur de puissance experimental LAMPRE est fonde sur l'utilisation d'une solution de phosphate d'uranium a haute temperature. Cette solution est tres corrosive et toutes les parties en contact avec elle ont un revetement en or. On a eu recours a des techniques radiographiques speciales pour controler l'or pendant le processus de laminage d'un lingot coule. On a procede de la meme maniere a l'inspection des soudures. Une methode d'inspection fondee sur les variations de potentiel aux electrodes a ete mise au point, pour la detection d'impuretes sur les surfaces d'or. Le reacteur experimental au plutonium fondu LAPRE est fonde sur l'utilisation de plutonium metallique, sous forme liquide plutot que sous forme solide, comme combustible. Le combustible est contenu dans des capsules en tantale. On a eu recours a des methodes non destructives pour verifier le bon etat du metal de base et des soudures pendant la fabrication des capsules, ainsi que pour controler les capsules remplies de plutonium avant, pendant et apres les essais de fusion et solidification. L'essai d'une pompe a plutonium fondu a ete suivi par des methodes radiographiques, en utilisant notamment un circuit ferme de television a rayons gamma. Pour le reacteur experimental a tres haute
Par Pond vegetation status 1996

International Nuclear Information System (INIS)

Mackey, H.E. Jr.; Riley, R.S.

1996-12-01

The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the newly emergent, shoreline aquatic plant communities of Par Pond began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level. These surveys continued in July, September, and late October, 1995, and into the early spring and late summer of 1996. Communities similar to the pre-drawdown, Par Pond aquatic plant communities continue to become re-established. Emergent beds of maidencane, lotus, waterlily, watershield, and Pontederia are extensive and well developed. Measures of percent cover, width of beds, and estimates of area of coverage with satellite data indicate regrowth within two years of from 40 to 60% of levels prior to the draw down. Cattail occurrence continued to increase during the summer of 1996, especially in the former warm arm of Par Pond, but large beds common to Par Pond prior to the draw down still have not formed. Lotus has invaded and occupies many of the areas formerly dominated by cattail beds. To track the continued development of macrophytes in Par Pond, future surveys through the summer and early fall of 1997, along with the evaluation of satellite data to map the extent of the macrophyte beds of Par Pond, are planned
Contribution to the studies on the mineral content of plant material through radioactivation analysis; Contribution a l'etude de la composition minerale des matieres vegetales au moyen de l'analyse par radioactivation

Energy Technology Data Exchange (ETDEWEB)

Fourcy, A [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1968-03-15

Radioactivation analysis is by its great sensibility or its rapidity quite helpful in plant biology and agronomy. Specific composition of plants and results to obtain in biological experimentation have needed a practical research on analytical methods for plant materials, using for radioactivation swimming-pool reactor neutrons and 14 MeV neutrons from a generator. Dosage process for 25 elements is exposed, taking account of the interest of the analysis for each element, the average amount occurring in plants and the result obtained. Many applications are developed, concerning nutrition physiology, genetics, parasitology, toxicology, control of manufactured agricultural and pharmaceutical products industrial and pesticides residues, ecology, radioecology and biochemistry. (author) [French] L'analyse par radioactivation, par sa grande sensibilite ou sa rapidite, est susceptible de rendre de nombreux services en biologie vegetale et en agronomie. La composition particuliere des plantes et les buts recherches dans l'experimentation ont exige une etude concrete des methodes d'analyse propres a la matiere vegetale en utilisant, pour la radioactivation, soit un reacteur de type piscine a eau legere, soit un accelerateur generateur de neutrons de 14 MeV. Le mode de dosage de 25 elements est expose en tenant compte de l'interet de l'analyse de chaque element, des teneurs moyennes rencontrees dans les plantes, et du resultat atteint. De nombreuses applications sont developpees qui touchent a la physiologie de la nutrition, la genetique, la parasitologie, la toxicologie, le controle des fabrications, les pollutions industrielles, l'ecologie, la radioecologie et la biochimie. (auteur)
Contribution to the study of nuclear fuel materials with a metallic uranium base; Contribution a l'etude des materiaux combustibles nucleaires a base d'uranium metallique

Energy Technology Data Exchange (ETDEWEB)

Englander, M. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1957-11-15

In a power reactor destined to supply industrially recoverable thermal energy, the most economical source of heat still consists of natural metallic uranium. However, the nuclear fuel material, most often employed in the form of rods of 20 to 40 mm diameter, is subjected to a series of stresses which lead to irreversible distortions usually incompatible with the substructure of the reactor. As a result the fuel material must possess at the outset a certain number of qualities which must be determined. Investigations have therefore been carried out, first on the technological characters peculiar to each of the three allotropic phases of pure uranium metal, and on their interactions on the stabilisation of the material which consists of either cast uranium or uranium pile-treated in the {gamma} phase. (author) [French] Dans un reacteur de puissance destine a fournir de l'energie thermique industriellement recuperable, la source de chaleur la plus economique reste constituee par de l'uranium metallique naturel. Or, le materiau combustible nucleaire, employe le plus souvent sous forme de barreaux de 20 a 40 mm de diametre, se trouve soumis a un ensemble de contraintes qui provoque des deformations irreversibles, le plus souvent incompatibles avec l'infrastructure du reacteur. Par consequent, le materiau combustible doit presenter a l'origine un certain nombre de qualites qu'il est necessaire de determiner. Aussi a-t-on d'abord etudie les caracteres technologiques propres a chacune des trois phases allotropiques de l'uranium-metal pur et leurs interactions sur la stabilisation du materiau constitue soit par de l'uranium coule, soit par de l'uranium traite en pile en phase {gamma}. (auteur)
Effect of the plutonium isotopic composition on the performance of fast reactors; Effet de la composition isotopique du plutonium sur le rendement de reacteurs a neutrons rapides; Vliyanie izotopnogo sostava plutoniya na rabotu reaktorov na bystrykh nejtronakh; Efectos de la composicion isotopica del plutonio sobre el funcionamiento de los reactores rapidos

Energy Technology Data Exchange (ETDEWEB)

Yiftah, S [Israel Atomic Energy Commission (Israel)

1962-03-15

son origine. En principe, ce plutonium peut provenir de trois sources differentes; a) reacteurs plutonigenes; b) reacteurs de puissance a neutrons thermiques, utilisant l'uranium naturel ou l'uranium enrichi comme combustible; c) couches fertiles de reacteurs a neutrons rapides. En general, la source a) et, a un degre moindre, la source c) fourniront du plutonium relativement , c'est-a-dire compose en majeure partie de {sup 239}Pu, tandis que le plutonium provenant de la source b) sera un plutonium , c'est-a-dire un plutonium contenant une forte proportion de {sup 240}Pu, {sup 241}Pu et {sup 242}Pu. Ce plutonium sera plus ou moins suivant le type du reacteur, le taux de combustion et, de maniere generale, suivant l'irradiation subie par le combustible. La question qui se pose est alors la suivante: peut-on utiliser comme combustible, dans les reacteurs a neutrons rapides, n'importe quelle sorte de plutonium? Pour etudier l'effet des differentes compositions isotopiques de plutonium utilise comme combustible sous forme de metal, d'oxyde ou de carbure, sur le rendement de reacteurs a neutrons rapides, les auteurs ont procede a une serie de calculs dans une theorie de la diffusion a 16 groupes en geometrie spherique; ils ont utilise a cet effet l'ensemble de sections efficaces a 16 groupes, recemment mis au point par Yiftah, Okrent et Moldauer, et ont etudie trois types differents de plutonium en prenant d'abord le {sup 239}Pu a l'etat pur et en augmentant ensuite la quantite des isotopes superieurs. Pour les systemes etudies - coeurs d'un volume de 800, 500 et 2500 l, qui sont courants pour les grands reacteurs de puissance a neutrons rapides - on constate, en ne tenant compte que des isotopes {sup 239}Pu et {sup 241}Pu, fissiles sous l'action de neutrons thermiques, que plus le plutonium est , plus la masse critique est faible et plus le rapport de conversion est eleve. Dans le cas d'un reacteur dont le coeur a un volume de 1500 l, on
Change of I-V characteristics of SiC diodes upon reactor irradiation; Modification des caracteristiques I-V de jonctions p-n au SiC du fait d'une irradiation dans un reacteur; Izmeneniya kharakteristik I-V vyrashchennogo v SiC perekhoda tipa p-n posle oblucheniya ego v reaktore; Modificaciones que sufren por irradiacion en un reactor las caracteristicas I-V de uniones p-n en SiC

Energy Technology Data Exchange (ETDEWEB)

Heerschap, M; De Coninck, R [Solid State Physics Dept., SCK-CEN, Mol (Belgium)

1962-04-15

In search for semiconductors, which can be used in high-flux reactors in order to measure flux distributions, we irradiated SiC p-n junctions in the Belgium BR-1 reactor. Two types of SiC-diodes of different origin have been irradiated. These junctions are grown in the Lely-furnace. The change in forward and reverse characteristics have been measured during and after irradiation up to temperatures of 150{sup o}C, while measurements up to a temperature of 500{sup o}C are in progress. It has been found that one type resists BR-1 neutrons up to an integrated flux of 10{sup 15} n/cm{sup 2}, while the other resists irradiation up to a flux of 10{sup 17} n/cm{sup 2}. The changes in characteristics are given as well as the result of some annealing experiments. (author) [French] En recherchant des semi-conducteurs pouvant servir a mesurer les distributions de flux dans les reacteurs a haut flux de neutrons, les auteurs ont irradie des jonctions p-n au SiC dans le reacteur belge BR-1. Deux types de diodes a SiC d'origines differentes ont ete ainsi irradies. Les jonctions en question sont preparees par etirage dans le four Lely. Les auteurs ont mesure les modifications subies par les caracteristiques I-V apres et pendant l'irradiation a des temperatures allant jusqu'a 150{sup o}C; ils poursuivent leurs mesures dans la gamme des temperatures allant de 150{sup o}C a 500{sup o}C. Us ont constate que l'un des types de diode a SiC resiste aux neutrons du reacteur BR-1 jusqu'a 10{sup 15} n/cm{sup 2}, tandis que l'autre type resiste a l'irradiation jusqu'a 10{sup 17} n/cm{sup 2}. Les auteurs indiquent les modifications subies par les caracteristiques, ainsi que le resultat de certaines experiences de recuit. (author) [Spanish] Los autores estan tratando de encontrar semiconductores con los que sea posible medir distribuciones de flujo en reactores de flujo elevado, y con este fin irradiaron uniones p-n del SiC en el reactor BR-1 de Belgica. Irradiaron dos tipos de diodos de SiC de
Ultrasonic testing of canning tubes in stainless steel of the EL 4 reactor; Controle par ultrasons des tubes de gaine en acier inoxydable du reacteur EL 4

Energy Technology Data Exchange (ETDEWEB)

Prot, A; Monnier, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

From all the methods possible for controlling thin cans the one chosen, for numerous reasons, vas that making use of ultrasonic techniques. A method has been developed which should make it possible to carry out a rapid and efficient industrial control of canning tubes, The reasons for the choice of the ultrasonic method are given in detail, together with the principles of the method and the actual control parameters. In the present state of our research, it should be possible to control at least 50 000 tubes a year. Improvements brought about in the details of the control technique itself should make it possible to increase this rate considerably. (authors) [French] Parmi toutes les methodes possibles de controle des gaines minces, le procede retenu pour de multiples raisons a ete celui faisant appel a la technique des ultrasons. Une methode a ete mise au point qui doit permettre un controle industriel rapide et efficace des tubes de gaine. Sont exposes en detail, les raisons du choix de la methode par ultrasons, les principes de cette methode et les parametres du controle proprement dit. Dans l'etat actuel de nos etudes la cadence devrait permettre le controle de 50000 tubes par an au minimum. Des ameliorations de detail portant sur la technique de controle elle-meme, doivent permettre d'accelerer tres notablement cette cadence. (auteurs)
The Use of Prestressed Concrete Vessels in the French Power Reactor Programme; Les caissons en beton precontraint dans le programme francais des reacteurs de puissance; Korpusy iz predvaritel'no napryazhennogo betona vo frantsuzskoj programme ehnergeticheskikh reaktorov; Empleo de recipientes de presion de hormigon pretensado en el programa frances de reactores de potencia

Energy Technology Data Exchange (ETDEWEB)

Conte, F. [Centre d' Etudes Nucleaires de Marcoule (France); Dambrine, C. [Centre d' Etudes Nucleaires de Fontenay-aux-Roses (France); Gaussot, D. [Electricite de France, Clamart (France)

1963-10-15

This paper deals with the use of pre-stressed concrete for the G2 and G3 reactors at Marcoule and for the EDF3 reactor now under construction at Chinon. The first two reactors have been operating at power since 1959 and 1960 respectively. Messrs. Conte and Dambrine discuss the problems that arose during construction of the vessels for G2 and G3 and also deal with the experience gained in operation - experience which suggests that they are extremely safe- Work on the EDF3 vessel, begun at Chinon in the second half of 1961, is still under way and should be finished towards the end of 1963. Mr. Gaussot discusses the reasons for choosing this type of vessel, the results of calculations and mock-up tests, and the problems presented by the construction itself. A number of studies have been devoted to the future prospects of prestressed concrete structures for reactors. It would seem that working pressures could be increased, if desired, and, in any case, that dimensions could be considerably enlarged, thus offering the chance of integral-type solutions. (author) [French] La communication traite de l'application du beton precontraint aux reacteurs G2 et G3 de Marcoule et au reacteur EDF 3, en construction a Chinon. Les reacteurs sont en puissance depuis respectivement 1959 et I960; le CEA indique les problemes qui se sont poses pendant la construction du caisson du reacteur, et la lecon tiree des observations faites en service, qui tend a demontrer la tres grande securite de ces appareils. La construction du caisson de EDF3 a commence a Chinon dans la deuxieme partie de 1961; elle est en cours actuellement et sera terminee vers la fin de 1963. L'EDF presente les raisons du choix de ce caisson, les resultats des calculs et des essais sur maquette ainsi que les problemes poses par la construction. Diverses etudes ont ete faites sur les perspectives futures des ouvrages en beton precontraint pour reacteurs. Il semble que l 'on puisse realiser, si on le desire, une elevation
Contribution to the studies on the mineral content of plant material through radioactivation analysis; Contribution a l'etude de la composition minerale des matieres vegetales au moyen de l'analyse par radioactivation

Energy Technology Data Exchange (ETDEWEB)

Fourcy, A. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1968-03-15

Radioactivation analysis is by its great sensibility or its rapidity quite helpful in plant biology and agronomy. Specific composition of plants and results to obtain in biological experimentation have needed a practical research on analytical methods for plant materials, using for radioactivation swimming-pool reactor neutrons and 14 MeV neutrons from a generator. Dosage process for 25 elements is exposed, taking account of the interest of the analysis for each element, the average amount occurring in plants and the result obtained. Many applications are developed, concerning nutrition physiology, genetics, parasitology, toxicology, control of manufactured agricultural and pharmaceutical products industrial and pesticides residues, ecology, radioecology and biochemistry. (author) [French] L'analyse par radioactivation, par sa grande sensibilite ou sa rapidite, est susceptible de rendre de nombreux services en biologie vegetale et en agronomie. La composition particuliere des plantes et les buts recherches dans l'experimentation ont exige une etude concrete des methodes d'analyse propres a la matiere vegetale en utilisant, pour la radioactivation, soit un reacteur de type piscine a eau legere, soit un accelerateur generateur de neutrons de 14 MeV. Le mode de dosage de 25 elements est expose en tenant compte de l'interet de l'analyse de chaque element, des teneurs moyennes rencontrees dans les plantes, et du resultat atteint. De nombreuses applications sont developpees qui touchent a la physiologie de la nutrition, la genetique, la parasitologie, la toxicologie, le controle des fabrications, les pollutions industrielles, l'ecologie, la radioecologie et la biochimie. (auteur)
Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis

NARCIS (Netherlands)

Lin, Cong; von der Thüsen, Jan; Daalhuisen, Joost; ten Brink, Marieke; Crestani, Bruno; van der Poll, Tom; Borensztajn, Keren; Spek, C. Arnold

2015-01-01

Idiopathic pulmonary fibrosis is the most devastating diffuse fibrosing lung disease of unknown aetiology. Compelling evidence suggests that both protease-activated receptor (PAR)-1 and PAR-2 participate in the development of pulmonary fibrosis. Previous studies have shown that bleomycin-induced
Processing Th C{sub 2} - UC{sub 2} fuel extracted from high temperature reactors HTGCR; Etude du traitement des combustibles Th C{sub 2} - UC{sub 2} issus de reacteurs a haute temperature

Energy Technology Data Exchange (ETDEWEB)

Derrien, C; Lessart, P; Pianezza, E; Verry, C; Villain, G [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1969-07-01

The object of this investigation is solubilisation head-end (from crushing and grinding phase to non included first purification phase) of pulverulent ({sup 233}U/{sup 232}Th)C{sub 2} (200 - 500 microns diameter) contained in a graphite matrix extracted from a 4.10{sup 13} n.cm{sup -2}.s{sup -1} thermalized neutrons average flux with an irradiation of 80000 MWjT{sup -1} HTGCR reactor. After having succinctly described different bibliographic processes we have chosen the burn - leach of reactor fuel and graphite matrix containing it. The technology of burner is original in nuclear field and still more by utilizing ultra-sounds to intensify burning reaction and to minimize the weight of unburnables. The mixture of ThO{sub 2}, U{sub 3}O{sub 8}, and fission products oxides is solubilized by boiling HNO{sub 3} 13 M + HF 0.05 M. This process is profit-learning in a thorium recuperation and reprocessing point of view. In the contrary-case it would be interesting to consider a dry-process which would permit to separate solid ThF{sub 4} from gaseous UF{sub 6}. (authors) [French] Cette etude a pour objet le traitement initial de mise en solution ou 'head-end' (allant de la phase broyag-concassage a la phase de premiere purification exclue) d'un combustible ({sup 233}U/{sup 232}Th)C{sub 2} pulverulent (de 200 a 500 {mu} de diametre) contenu dans une matrice de graphite issu d'un reacteur HTGCR surgenerateur a neutrons thermiques de flux moyen 4. l0{sup 13} n.cm{sup -2}.s{sup -1} et taux d'irradiation 80000 MWjT{sup -1}. Apres exposition succincte des differents procedes bibliographiques decrits, nous avons finalement choisi le traitement par combustion-attaque ('Burn-Leach') du combustible et de la matrice etanche graphite qui le contient. La technologie du bruleur est originale dans le domaine nucleaire d'autant qu'elle utilise les ultra-sons pour ameliorer le rendement de la reaction de combustion et reduire au minimum le poids des imbrules. Le melange ThO{sub 2}, U{sub 3}O
The control equipment of the Melusine II reactor; L'equipement de controle du reacteur Melusine II

Energy Technology Data Exchange (ETDEWEB)

Cordelle, M; Delcroix, V; Denis, P; Gariod, R

1963-07-01

Melusine II, low-power reactor, used for the study of Siloe core has diverged at the CEA Grenoble, the 23. May 1962; its monitoring board studied and carried out in this center is the first in France to be entirely transistorized. The first months of running have justified the hope put in the new electronics to improve the stability and the safety of running. The article describes the design of the control and gives the main characteristics of the measurement chains and of the actions on reactivity. (O.M.) [French] Melusine II, reacteur de faible puissance destine a l'etude du coeur de Siloe a diverge au Centre d'Etudes Nucleaires de Grenoble, le 23 mai 1962, son tableau de controle etudie et realise dans ce Centre est le premier en France a etre entierement transistorise. Les premiers mois de fonctionnement ont justifie l'espoir mis dans la nouvelle electronique pour ameliorer la stabilite et la surete de fonctionnement. L'article decrit la conception du controle et donne les principales caracteristiques des chaines de mesure et des actions sur la reactivite. (auteurs)
Information derived from French studies and achievements in the field of uranium isotope separation; Enseignements tires des etudes et realisations francaises relatives a la separation des isotopes de l'uranium

Energy Technology Data Exchange (ETDEWEB)

Frejacques, C; Galley, R [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

The work carried out in the field of uranium isotope separation, by gaseous diffusion and by ultracentrifugation, is reviewed. An economic estimate of the various parameters involved in the cost is given, and it is shown that only very large gaseous diffusion plants, corresponding to a programme of enriched uranium reactors of at least 4000 MWe to be installed yearly, can give an economically acceptable enriched uranium production. (authors) [French] La communication passe en revue les realisations effectuees dans le domaine de la separation des isotopes de l'uranium, par diffusion gazeuse et par ultracentrifugation. Elle donne une estimation economique des differents parametres intervenant dans les couts et met en evidence que seules les tres grandes usines de diffusion gazeuse, correspondant a un programme d'installation de reacteurs a uranium enrichi d'au moins 4000 MWe nouveaux par an, peuvent conduire a des productions d'uranium enrichi economiquement acceptables. (auteurs)
Description of a Reactivity Measuring Apparatus; Description d'un Type d'Appareil de Mesure de la Reactivite

Energy Technology Data Exchange (ETDEWEB)

Deiss, M.; Uberschlag, J. [Centre d' Etudes Nucleaires de Saclay (France)

1966-06-15

apparatuses have different dividers in the output unit, in the one case Potentiometric, and in the other electronic. The first apparatus is suitable in principle for most normal measurements. The second, by reason of its shorter response time, is suited both to measurements of higher reactivity values with the reactor level rising, and also with the reactor level falling, even over limited power ranges. (author) [French] La mesure de la periode ou du temps de doublement fournit en general au technicien du controle des reacteurs une information suffisante sur l'evolution du reacteur. Le physicien attache a la determination de parametres physiques ne peut se satisfaire de la mesure ordinaire de ces grandeurs, dont les concepts font abstraction de la nature du phenomene de la fission nucleaire. Habituellement le physicien doit donc convertir la mesure du temps de doublement, effectuee sur un temps suffisamment long, afin d'en eliminer les termes transitoires perturbateurs, et convertir, par intermediaire des courbes de Nordheim, cette mesure en valeur de reactivite. Cette procedure est longue et contraignante. Il a donc semble utile de concevoir un type d'appareil capable d'evaluer directement et instantanement le coefficient de multiplication excedentaire Greek-Small-Letter-Delta K a partir de l'evolution d'une grandeur physique N supposee proportionnelle au flux neutronique regnant dans le coeur du reacteur. Le coefficient Greek-Small-Letter-Delta K est pratiquement assimilable a la reactivite au voisinage de la criticalite. Un appareil de ce type peut en consequence resoudre la relation inverse a celle definie par le systeme des equations differentielles se rapportant au reacteur, en considerant le cas simplifie du reacteur point dans la theorie a un groupe. L'application des techniques du calcul analogique conduit a utiliser un reseau du type Pagels qui sera dispose, soit comme impedance d'entree, soit comme impedance de contre-reaction d'un amplificateur operationnel. Cette
Study of problems arising from the use of thermal neutron detectors in a pulsed regime. Application to the development of a digital transferometer adapted to receive signals from these detectors; Etude des problemes poses par l'utilisation des detecteurs de neutrons thermiques fonctionnant en regime impulsionnel. Application a la realisation d'un transferometre numerique adapte aux signaux fournis par ces detecteurs

Energy Technology Data Exchange (ETDEWEB)

Le Tilly, Y [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1966-12-01

The instantaneous value of the counting rate of the pulses given by a fission detector settled in a reactor follows the neutron flux, but it is shown that the counter adds a white noise to the measured signal. This report deals with some possibilities of on line numerical handling afforded by this kind of signals. One considers first the influence of a by N numerical divider and one shows that, acting like a quantifier, it adds to the signal a white noise with the power N{sup 2}/{sub 12}. One, studies afterwards the principle of a digital filter aimed to Fourier analyse the signal. The realization of this device is described. It can be used in transfer function measurements at frequencies below 125 kHz. Some examples of experiments performed with this apparatus are presented. One discusses finally the design, according to the same principle, of a power spectral density analyser in the frequency range 0,01 - 10 000 Hz for random signal of the same kind. (author) [French] La valeur instantanee de la frequence de recurrence des impulsions issues d'un detecteur a fission place dans un reacteur est proportionnelle au flux neutronique. Apres avoir montre que le detecteur ajoute un bruit blanc au signal mesure, on etudie clans ce rapport certaines possibilites de traitement numerique en temps reel offertes par ce type de signaux. On examine d'abord l'influence d'un diviseur numerique par N, et l'on montre que son action, semblable a une quantification, ajoute au signal un bruit blanc de puissance N{sup 2}/{sub 12}. On, etudie ensuite le principe d'un filtre numerique destine a effectuer l'analyse de Fourier du signal, et l'on decrit la realisation de cet appareil qui peut etre utilise pour mesurer des fonctions de transfert a une frequence quelconque inferieure a 10 kHz. Des exemples de mesures faites avec cet appareil sont presentes. On discute enfin la possibilite de realiser suivant le meme principe un analyseur de densite spectrale dans la bande de frequence 0,01 Hz

Par Pond vegetation status Summer 1995 -- Summary

International Nuclear Information System (INIS)

Mackey, H.E. Jr.; Riley, R.S.

1996-01-01

The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the newly emergent, shoreline aquatic plant communities of Par Pond began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level. These surveys continued in July, September, and late October, 1995. Communities similar to the pre-drawdown, Par Pond aquatic plant communities are becoming re-established. Emergent beds of maidencane, lotus, waterlily, and watershield are extensive and well developed. Cattail occurrence continued to increase during the summer, but large beds common to Par Pond prior to the drawdown have not formed. Estimates from SPOT HRV, remote sensing satellite data indicated that as much as 120 hectares of emergent wetlands vegetation may have been present along the Par Pond shoreline by early October, 1995. To track the continued development of macrophytes in Par Pond, future surveys throughout 1996 and 1997, along with the continued evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned
Neutron distribution in the central cell and a peripheral cell of the Fontenay-aux-Roses pile; Repartition des neutrons dans la cellule centrale et une cellule peripherique de la pile de Fontenay-aux-Roses

Energy Technology Data Exchange (ETDEWEB)

Roullier, F [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

1958-07-01

The distribution of the neutron density has been determined in the central cell and a peripheral cell of the pile at Fontenay-aux-Roses. This measurement was carried out by the autoradiographic method with manganese detectors. The neutron density distribution in the uranium rod has already been studied. The measurement was completed by the study of the neutron density in the complete cell by means of detectors placed in the uranium and in the heavy water. (author) [French] La repartition de la densite des neutrons a ete determinee dans la cellule centrale et une cellule peripherique de la pile de Fontenay-aux-Roses. Cette mesure a ete effectuee par la methode d'autoradiographie avec des detecteurs de manganese. La repartition de la densite des neutrons dans la barre d'uranium a deja ete etudiee. La mesure a ete completee par l'etude de la densite des neutrons dans la cellule complete a l'aide de detecteurs places dans l'uranium et dans l'eau lourde. (auteur)
A review of calculation methods for fast and intermediate reactors; Expose des methodes pour le calcul de reacteurs a neutrons rapides et intermediaires; Obzor metodov rascheta reaktorov na promezhutochnykh i bystrykh nejtronakh; Estudio panoramico de los metodos de calculo de los reactores rapidos e intermedios

Energy Technology Data Exchange (ETDEWEB)

Marchuk, G I [Akademiya Nauk, Moskva, Union of Soviet Socialist Republics (Russian Federation)

1962-03-15

This paper discusses the development of methods for calculating intermediate and fast reactors. It deals with various approaches to the problems of physical calculation. The calculation of resonance effects is discussed. Consideration is given to multi-group systems of fundamental and conjugate equations, various applications of perturbation theory to the problems of physical reactor calculation, and numerical methods of solving fundamental and conjugate reactor equations, which approximate the method of spherical harmonics. The paper describes an application of the response method to the solution of critical-mass problems, and methods of calculating reactors with hydrogeneous moderators. The fundamental features of an effective one-group reactor model are described. (author) [French] L'auteur examine la mise au point de methodes pour le calcul de reacteurs a neutrons rapides et intermediaires . Il decrit diverses manieres d'aborder les problemes des calculs sur la physique des reacteurs, notamment le calcul des effets de resonance. Il s'attache particulierement aux points suivants: systemes d'equations fondamentales et conjuguees a plusieurs groupes; diverses applications de la theorie des perturbations aux problemes de calculs sur la physique des reacteurs; methodes numeriques pour resoudre les equations fondamentales et conjuguees, voisines de la methode des harmoniques spheriques. L'auteur decrit ensuite une maniere d'appliquer la methode de la reponse aux problemes de la masse critique ainsi que des methodes pour le calcul de reacteurs ralentis a l'hydrogene. Il decrit les caracteristique s fondamentale s d'un modele de reacteur a un groupe effectif. (author) [Spanish] El autor analiza el desarrollo de los metodos de calculo de los reactores nucleares que trabajan con neutrones rapidos y con neutrones intermedios. Examina diversos planteos de los problemas del calculo fisico. Indica la forma de tomar en cuenta los efectos de resonancia y menciona los sistemas
ParABS system in chromosome partitioning in the bacterium Myxococcus xanthus.

Directory of Open Access Journals (Sweden)

Antonio A Iniesta

Full Text Available Chromosome segregation is an essential cellular function in eukaryotic and prokaryotic cells. The ParABS system is a fundamental player for a mitosis-like process in chromosome partitioning in many bacterial species. This work shows that the social bacterium Myxococcus xanthus also uses the ParABS system for chromosome segregation. Its large prokaryotic genome of 9.1 Mb contains 22 parS sequences near the origin of replication, and it is shown here that M. xanthus ParB binds preferentially to a consensus parS sequence in vitro. ParB and ParA are essential for cell viability in M. xanthus as in Caulobacter crescentus, but unlike in many other bacteria. Absence of ParB results in anucleate cells, chromosome segregation defects and loss of viability. Analysis of ParA subcellular localization shows that it clusters at the poles in all cells, and in some, in the DNA-free cell division plane between two chromosomal DNA masses. This ParA localization pattern depends on ParB but not on FtsZ. ParB inhibits the nonspecific interaction of ParA with DNA, and ParA colocalizes with chromosomal DNA only when ParB is depleted. The subcellular localization of ParB suggests a single ParB-parS complex localized at the edge of the nucleoid, next to a polar ParA cluster, with a second ParB-parS complex migrating after the replication of parS takes place to the opposite nucleoid edge, next to the other polar ParA cluster.
Handling and Separation of Short-Lived Radioisotopes from Research Reactors; Manipulation et Separation des Radioisotopes a Courte Periode Produits dans des Reacteurs de Recherche; ПОЛУЧЕНИЕ И ОТДЕЛЕНИЕ КОРОТКОЖИВУЩИХ ИЗОТОПОВ В ИССЛЕДОВАТЕЛЬСКИХ РЕАКТОРАХ; Manipulacion y Separacion de Radioisotopos de Periodo Corto Obtenidos en Reactores de Investigacion

Energy Technology Data Exchange (ETDEWEB)

Meinke, W. W. [University of Michigan, Ann Arbor, MI (United States)

1963-03-15

distillation, selective reduction, etc., also add to the variety of separation possibilities to be explored. The local research reactor, whether it is in a university in the United States, or in a developing country, thus opens a whole new era of tracer possibilities. (author) [French] L'emploi des radioisotopes a souvent ete limite aux radioisotopes dont la periode est superieure a un jour, etant donne l'eloignement du reacteur qui les produit. Ceci explique un certain manque d'interet a l'egard du traitement et de l'utilisation de ces radioisotopes, et par suite une certaine reticence de la part du consommateur a envisager meme les possibilites d'emploi de nombreux radioisotopes a courte periode. Comme il existe maintenant de nombreux reacteurs de recherche dans le monde, les laboratoires ne dependent plus de producteurs de radioisotopes eloignes; en outre, les radioisotopes a courte periode couvrent de nombreux champs d'experimentation nouveaux. Il importe, cependant, a cette fin de considerer la production des radioindicateurs sous un angle nouveau. Depuis pres de cinq annees, le programme execute au moyen du reacteur de recherche de l'Universite du Michigan comporte la manipulation, le traitement et la mesure de radioisotopes a courte periode. Les chercheurs de l'Universite emploient couramment des radioisotopes dont les periodes ne depassent pas plusieurs heures, voire quelques minutes. Les traveaux entrepris jusqu'a present avaient trait principalement a l'analyse par activation, mais le material, les methodes et les techniques utilises.peuvent s'appliquer a de nombreux autres domaines. Pour utiliser les radioisotopes a courte periode, il n'est pas necessaire de prevoir un roulement de trois equipes pour le reacteur; il n'est pas lion plus indispensable de disposer de stocks importants de radioisotopes, ni d'installations de traitement perfectionnees.En fait, de simples pinces, utilisees de la maniere courante, donnent generalement de meilleurs resultats que de
Localization of alpha emitters by damage production in a thin film. Application to the study of alpha emitter diffusion in irradiated samples; Localisation des emetteurs alpha par creation de dommages dans un film mince. Application a l'etude de la diffusion des emetteurs alpha dans des echantillons irradies

Energy Technology Data Exchange (ETDEWEB)

Houdaille, B; Perrot, M [Commissariat a l' Energie Atomique, 91 - Saclay (France). Centre d' Etudes Nucleaires

1968-07-01

comprise entre 0.5 et 4 MeV, il a tout d'abord fallu determiner le rendement de l'enregistreur pour les particules alpha emises par une source epaisse, c'est-a-dire dont l'energie varie entre O et E{sub 0}, E{sub 0} etant l'energie de l'emetteur alpha. - La concentration C de l'emetteur alpha, en fonction de la densite optique D de l' alphagraphie, et du temps de pose t, est donnee par une formule simple: C = D/at ou a est une constante experimentale, determinee par etalonnage. Elle depend de la nature du nitrate de cellulose, de l'element emetteur alpha et de l'alliage etudie. (auteurs)
Analysis of ParB-centromere interactions by multiplex SPR imaging reveals specific patterns for binding ParB in six centromeres of Burkholderiales chromosomes and plasmids.

Science.gov (United States)

Pillet, Flavien; Passot, Fanny Marie; Pasta, Franck; Anton Leberre, Véronique; Bouet, Jean-Yves

2017-01-01

Bacterial centromeres-also called parS, are cis-acting DNA sequences which, together with the proteins ParA and ParB, are involved in the segregation of chromosomes and plasmids. The specific binding of ParB to parS nucleates the assembly of a large ParB/DNA complex from which ParA-the motor protein, segregates the sister replicons. Closely related families of partition systems, called Bsr, were identified on the chromosomes and large plasmids of the multi-chromosomal bacterium Burkholderia cenocepacia and other species from the order Burkholeriales. The centromeres of the Bsr partition families are 16 bp palindromes, displaying similar base compositions, notably a central CG dinucleotide. Despite centromeres bind the cognate ParB with a narrow specificity, weak ParB-parS non cognate interactions were nevertheless detected between few Bsr partition systems of replicons not belonging to the same genome. These observations suggested that Bsr partition systems could have a common ancestry but that evolution mostly erased the possibilities of cross-reactions between them, in particular to prevent replicon incompatibility. To detect novel similarities between Bsr partition systems, we have analyzed the binding of six Bsr parS sequences and a wide collection of modified derivatives, to their cognate ParB. The study was carried out by Surface Plasmon Resonance imaging (SPRi) mulitplex analysis enabling a systematic survey of each nucleotide position within the centromere. We found that in each parS some positions could be changed while maintaining binding to ParB. Each centromere displays its own pattern of changes, but some positions are shared more or less widely. In addition from these changes we could speculate evolutionary links between these centromeres.
La pelade par plaques

Science.gov (United States)

Spano, Frank; Donovan, Jeff C.

2015-01-01

Résumé Objectif Présenter aux médecins de famille des renseignements de base pour faire comprendre l’épidémiologie, la pathogenèse, l’histologie et l’approche clinique au diagnostic de la pelade par plaques. Sources des données Une recension a été effectuée dans PubMed pour trouver des articles pertinents concernant la pathogenèse, le diagnostic et le pronostic de la pelade par plaques. Message principal La pelade par plaques est une forme de perte pileuse auto-immune dont la prévalence durant une vie est d’environ 2 %. Des antécédents personnels ou familiaux de troubles auto-immuns concomitants, comme le vitiligo ou une maladie de la thyroïde, peuvent être observés dans un petit sous-groupe de patients. Le diagnostic peut souvent être posé de manière clinique en se fondant sur la perte de cheveux non cicatricielle et circulaire caractéristique, accompagnée de cheveux en « point d’exclamation » en périphérie chez ceux dont le problème en est aux premiers stades. Le diagnostic des cas plus complexes ou des présentations inhabituelles peut être facilité par une biopsie et un examen histologique. Le pronostic varie largement et de mauvais résultats sont associés à une apparition à un âge précoce, une perte importante, la variante ophiasis, des changements aux ongles, des antécédents familiaux ou des troubles auto-immuns concomitants. Conclusion La pelade par plaques est une forme auto-immune de perte de cheveux périodiquement observée en soins primaires. Les médecins de famille sont bien placés pour identifier la pelade par plaques, déterminer la gravité de la maladie et poser le diagnostic différentiel approprié. De plus, ils sont en mesure de renseigner leurs patients à propos de l’évolution clinique de la maladie ainsi que du pronostic général selon le sous-type de patients.
Operating Experience in Nuclear Power Plants with Boiling-Water Reactors; Experience acquise dans l'exploitation des reacteurs a eau bouillante; Opyt ehkspluatatsii kipyashchago reaktora; Experiencia adquirida con la explotacion de reactores de agua hirviente

Energy Technology Data Exchange (ETDEWEB)

Ascherl, R. J. [General Electric Company, San Jose, CA (United States)

1963-10-15

radioactivity exposure considerations. Recent full-scale inspection and overhaul of the Dresden turbine provided no maintenance problems, after over 12 000 h of operation on direct-cycle steam and after operation with known failed fuel elements in the reactor. (author) [French] On a maintenant acquis une experience appreciable dans l'exploitation des centrales equipees de reacteurs a eau bouillante. Vers la fin de 1962, on avait produit plus de 2,2.10{sup 9} kWh dans trois centrales nucleaires rattachees a des reseaux de distribution: la centrale de Dresden (Commonwealth Edison Company, Morris, Illinois), la centrale de Vallecitos (Pacific Gas and Electric Company and General Electric Company, Pleasanton, Californie) et la centrale de Kahl (Rheinish-Westfaiisches Elektrizitatswerk et Bayemwerk, a Kahl-sur-le-Main, Republique federale d'Allemagne). Le rendement de ces reacteurs a eau bouillante, exploites dans les conditions normales de production d'electricite, est excellent. On peut donc s'attendre que les centrales a eau bouillante continueront d'etre sures, etant donne le facteur de disponibilite et le facteur de puissance des reacteurs et des installations de ce type. Au cours de 1963, quatre nouvelles centrales equipees de reacteurs a eau bouillante entreront en service: la centrale de Big Rock Point (Consumers Power Company, Charlevoix, Michigan), la centrale de Humboldt Bay (Pacific Gas and Electric Company, Eureka, Californie), la centrale de Garigliano (Societa Elettronucleare Nazionale, Scauri, Italie) et la centrale de demonstration japonaise (Institut de recherches nucleaires du Japon, Tokai Mura, Japon). Les resultats obtenus lors du demarrage et pendant le fonctionnement initial de ces installations confirment les espoirs suscites par les centrales de Dresden, Kahl et Vallecitos. Les journaux de marche des centrales de Dresden, Kahl et Vallecitos mettent en evidence la stabilite et la securite des reacteurs a eau bouillante. De plus, les niveaux de rayonnements
Keratometric alterations following the 25-gauge transconjunctival sutureless pars plana vitrectomy versus the conventional pars plana vitrectomy.

Science.gov (United States)

Citirik, Mehmet; Batman, Cosar; Bicer, Tolga; Zilelioglu, Orhan

2009-09-01

To assess the alterations in keratometric astigmatism following the 25-gauge transconjunctival sutureless pars plana vitrectomy versus the conventional pars plana vitrectomy. Sixteen consecutive patients were enrolled into the study. Conventional vitrectomy was applied to eight of the cases and 25-gauge transconjunctival sutureless vitrectomy was performed in eight patients. Keratometry was performed before and after the surgery. In the 25-gauge transconjunctival sutureless pars plana vitrectomy group, statistically significant changes were not observed in the corneal curvature in any post-operative follow-up measurement (p > 0.05); whereas in the conventional pars plana vitrectomy group, statistically significant changes were observed in the first postoperative day (p = 0.01) and first postoperative month (p = 0.03). We noted that these changes returned to baseline in three months (p = 0.26). Both 25-gauge transconjunctival sutureless and conventional pars plana vitrectomy are effective surgical modalities for selected diseases of the posterior segment. Surgical procedures are critical for the visual rehabilitation of the patients. The post-operative corneal astigmatism of the vitrectomised eyes can be accurately determined at least two months post-operatively.
Centromere pairing by a plasmid-encoded type I ParB protein

DEFF Research Database (Denmark)

Ringgaard, Simon; Löwe, Jan; Gerdes, Kenn

2007-01-01

The par2 locus of Escherichia coli plasmid pB171 encodes two trans-acting proteins, ParA and ParB, and two cis-acting sites, parC1 and parC2, to which ParB binds cooperatively. ParA is related to MinD and oscillates in helical structures and thereby positions ParB/parC-carrying plasmids regularly......, hence identifying the N terminus of ParB as a requirement for ParB-mediated centromere pairing. These observations suggest that centromere pairing is an important intermediate step in plasmid partitioning mediated by the common type I loci....
Single Pellet String Reactor for Intensification of Catalyst Testing in Gas/Liquid/Solid Configuration Réacteur catalytique de type “filaire” pour l’intensification de tests catalytiques en configuration gaz/liquide/solide

Directory of Open Access Journals (Sweden)

Hipolito A.I.

2010-09-01

has been shown that the pressure drop is controlled by the liquid/solid friction surface and that the pressure drop is not a limiting parameter in the reactor’s operation (values always lower than 0.1 bar. So, from a hydrodynamic point of view, this new reactor exhibits characteristics suitable for its use in catalytic tests. Finally, this reactor was implemented under reaction conditions to study hydrogenation reactions with a real industrial catalyst. The selective hydrogenation of allene was studied. The string reactor was shown to run isothermal kinetic tests with a very small amount of industrial-sized catalyst particles (less than 2 cc and to explore kinetics of fast reaction at high space velocities impossible to achieve in standard fixed bed units with appropriate hydrodynamic conditions. For constant residence time, the allene conversion does not vary with pressure and feed flow rate, which confirms that the string reactor allows one to perform catalytic tests with such a fast reaction without external mass transfer resistance. L’optimisation du catalyseur est une etape cle pour l’optimisation d’un procede catalytique du point de vue des rendements, de l’efficacite energetique et de la selectivite des reactions. La strategie de developpement d’un catalyseur comprend des tests effectues sur des reacteurs pilotes avec des charges reelles ou modeles. Cette etape a fait l’objet de nombreuses etudes ces dernieres decennies portant sur le dimensionnement des reacteurs, l’amelioration des outils d’analyses et les procedures operatoires. La plupart des etudes ont pour but de determiner l’activite catalytique de catalyseur sous forme de grain dans des conditions isothermes de facon a pouvoir determiner les parametres cinetiques de la reaction. Avec l’optimisation des catalyseurs, les flux de transfert de matieres externes aux grains peuvent devenir l’etape limitante, dans les reacteurs de laboratoire standard, par rapport aux flux de reaction
Use of an oscillation technique to measure effective cross-sections of fissionable samples in critical assemblies; Mesure des sections efficaces effectives d'echantillons fissiles par une methode d'oscillation dans les-assemblages critiques

Energy Technology Data Exchange (ETDEWEB)

Tretiakoff, O; Vidal, R; Carre, J C; Robin, M [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

The authors describe the technique used to measure the effective absorption and neutron-yield cross-sections of a fissionable sample. These two values are determined by analysing the signals due to the variation in reactivity (over-all signal) and the local perturbation in the flux (local signal) produced by the oscillating sample. These signals are standardized by means of a set of samples containing quantities of fissionable material ({sup 235}U) and an absorber, boron, which are well known. The measurements are made for different neutron spectra characterized by lattice parameters which constitute the central zone within which the sample moves. This technique is used to study the effective cross-sections of uranium-plutonium alloys for different heavy-water and graphite lattices in the MINERVE and MARIUS critical assemblies. The same experiments are carried out on fuel samples of different irradiations in order to determine the evolution of effective cross-sections as a function of the spectrum and the irradiations. (authors) [French] On decrit la methode utilisee pour mesurer les sections efficaces effectives d'absorption et de production de neutrons d'un echantillon fissile. Ces deux grandeurs sont determinees en analysant les signaux dus a la variation de reactivite (signal global) et a la perturbation locale de flux (signal local) produits par l'echantillon oscillant. Ces signaux sont etalonnes a l'aide d'un jeu d'echantillons dont les teneurs en materiau fissile ({sup 235}U) et en absorbeur (bore) sont bien connues. Les mesures sont realisees pour differents spectres de neutrons caracterises par les parametres du reseau constituant la zone centrale a l'interieur de laquelle se deplace l'echantillon. A l'aide de cette methode on etudie les sections efficaces effectives d'alliage uranium-plutonium pour differents reseaux a eau lourde et a graphite dans les assemblages crtiques MINERVE et MARIUS. Les memes experiences sont effectuees sur des echantillons de
Analysis of ParB-centromere interactions by multiplex SPR imaging reveals specific patterns for binding ParB in six centromeres of Burkholderiales chromosomes and plasmids.

Directory of Open Access Journals (Sweden)

Flavien Pillet

Full Text Available Bacterial centromeres-also called parS, are cis-acting DNA sequences which, together with the proteins ParA and ParB, are involved in the segregation of chromosomes and plasmids. The specific binding of ParB to parS nucleates the assembly of a large ParB/DNA complex from which ParA-the motor protein, segregates the sister replicons. Closely related families of partition systems, called Bsr, were identified on the chromosomes and large plasmids of the multi-chromosomal bacterium Burkholderia cenocepacia and other species from the order Burkholeriales. The centromeres of the Bsr partition families are 16 bp palindromes, displaying similar base compositions, notably a central CG dinucleotide. Despite centromeres bind the cognate ParB with a narrow specificity, weak ParB-parS non cognate interactions were nevertheless detected between few Bsr partition systems of replicons not belonging to the same genome. These observations suggested that Bsr partition systems could have a common ancestry but that evolution mostly erased the possibilities of cross-reactions between them, in particular to prevent replicon incompatibility. To detect novel similarities between Bsr partition systems, we have analyzed the binding of six Bsr parS sequences and a wide collection of modified derivatives, to their cognate ParB. The study was carried out by Surface Plasmon Resonance imaging (SPRi mulitplex analysis enabling a systematic survey of each nucleotide position within the centromere. We found that in each parS some positions could be changed while maintaining binding to ParB. Each centromere displays its own pattern of changes, but some positions are shared more or less widely. In addition from these changes we could speculate evolutionary links between these centromeres.
The use and evolution of the CEA research reactors; Utilisation et evolution des reacteurs de recherche du C.E.A

Energy Technology Data Exchange (ETDEWEB)

Rossillon, F; Chauvez, C [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

reacteurs en montrant ce qu'a ete jusqu'a present leur utilisation, et comment certaines modifications ont permis de les adapter a l'evolution des programmes. Ils precisent egalement les raisons qui ont conduit a l'elaboration du projet de la nouvelle pile OSIRIS, La pile ZOE, la plus ancienne du CEA, est en service au Centre de Fontenay-aux-Roses depuis 1948. Elle est principalement utilisee pour les mesures de section efficace d'absorption du graphite, et pour diverses irradiations de courte duree ne necessitant que des flux peu eleves. La Pile EL2, en service depuis 1952, a permis les premieres etudes liees au refroidissement par gaz. Elle a ete tres utilisee pour la production des radioisotopes et pour de nombreuses experiences de physique, de metallurgie et de physico-chimie - le vieillissement de certaines parties du reacteur a conduit a decider l'arret prochain de cette installation. La Pile EL. 3 a ete tres utilisee pour les experiences de physique et pour l'etude des combustibles. L'adoption d'une nouvelle structure pour le coeur (solution 'Cristal de neige') va permettre d'accroitre considerablement les possibilites de la pile pour les irradiations en neutrons rapides. La pile TRITON-I, piscine de 2 MW, est surtout utilisee pour les irradiations en neutrons rapides et en gamma. Certaines modifications, actuellement en cours, permettront d'accroitre la puissance du reacteur jusqu'a 4 ou 5 MW. Dans un compartiment voisin de TRITON-I est implantee la Pile TRITON-II, de meme structure generale, mais dont la puissance maximum est de 100 kW. TRITON-II est utilisee exclusivement pour les etudes de protections. MELUSINE, pile piscine de 2 MW est en fonctionnement au Centre d'Etudes Nucleaires de Grenoble depuis 1959. Elle a permis l'execution d'un programme important concernant surtout la physique du solide, l'etude fondamentale de combustibles refractaires et de graphites speciaux, et l'etude du comportement des liquides organiques sous radiations. Les installations de
Rapsodie; Rapsodie

Energy Technology Data Exchange (ETDEWEB)

Vendryes, G [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; D' Ayguevives, Ch [Groupement Atomique Alsacienne Atlantique (France); Sahl, W [Association Euratom-CEA Cadarache, 13 - Saint-Paul-lez-Durance (France)

1964-07-01

interesting studies were carried out on the safety of Rapsodie, and in particular scale models (1/3 and 1/10) were used to estimate the damage caused by the theoretical maximum nuclear accident. The construction of the reactor was started in the autumn of 1961. The industrial architects are the Groupement Atomique Alsacienne Atlantique (G. AAA). A brief outline of the current situation in the construction will be given. (authors) [French] Rapsodie, le premier reacteur a neutrons rapides construit on France dans le cadre d'une Association entre Euratom et le CEA, repond a un triple but: - Il servira d'abord de reacteur experimental dont on etudiera en detail le comportement en regime statique et dynamique, - Les enseignements retires de sa construction et de son fonctionnement serviront a developper la technologie des futurs reacteurs industriels a neutrons rapides. - Son flux de neutrons rapides sera suffisant pour lui permettre de servir aux essais sous irradiation d'elements combustibles pour les reacteurs a neutrons rapides suivants. Rapsodie ayant deja fait l'objet de descriptions, on se contentera d'en faire ici une presentation tres breve en insistant sur les points particulierement significatifs et sur les recentes modifications du projet. Seront successivement evoques: - les principales caracteristiques neutroniques et thermiques, - les assemblages combustibles et fertiles, - le bloc pile et les circuits de refroidissement, - les principaux moyens de manutention des assemblages, - les principes et moyens qui regissent la conduite et la surete du reacteur. La construction du reacteur a ete precedee par la realisation de maquettes en vraie grandeur de ses parties essentielles comprenant notamment: - un circuit complet de sodium do 10 MW, prototype des deux circuits qui equiperont le reacteur, - une maquette du bloc pile (cuve, fermeture superieure, structures internes du coeur et de la couverture), munie d'un circuit de sodium special permettant d'effectuer des essais d
CFD analysis of PAR performance as function of inlet design

International Nuclear Information System (INIS)

Park, Kweonha; Khor, Chong Lee

2016-01-01

Highlights: • The new concept of PAR (passive autocatalytic recombiner) was proposed and analyzed. • Guidance wall was added at the bottom of PAR to enhance the flow rate through the catalyst. • The new concept of PAR was proved to have a better hydrogen removal performance. - Abstract: Passive autocatalytic recombiner (PAR) is very useful hydrogen mitigation measurement. It is widely implemented in the current and advanced light water reactors (ALWRs). The design of the PARs should be optimized for the specific use under severe accident scenarios. Several techniques and innovations have been fused into the PAR, as an effort to increase its efficiency of hydrogen mitigation. This study proposes different concepts of PAR, which applied some changes to the honeycomb catalyst PAR made by the Korea Nuclear Technology (KNT) Inc. Two slices of plate are added to the bottom of PAR model, which intended to act as a reflection wall and promote the gas flow into PAR. Hydrogen volume fraction was given 4 vol. % which tested by KNT to investigate the performance of PAR in different direction gas flow conditions to see maximum hydrogen recombination rate. The new concept of PAR was proved to have a better hydrogen removal performance compared to the original honeycomb catalyst PAR.
CFD analysis of PAR performance as function of inlet design

Energy Technology Data Exchange (ETDEWEB)

Park, Kweonha, E-mail: khpark@kmou.ac.kr [Division of Mechanical and Energy systems Engineering, Korea Maritime University, Dongsam-dong, Yeongdo-gu, Busan 606-791 (Korea, Republic of); Khor, Chong Lee, E-mail: itachi_829@hotmail.com [Department of Mechanical Engineering, Korea Maritime University (Korea, Republic of)

2016-01-15

Highlights: • The new concept of PAR (passive autocatalytic recombiner) was proposed and analyzed. • Guidance wall was added at the bottom of PAR to enhance the flow rate through the catalyst. • The new concept of PAR was proved to have a better hydrogen removal performance. - Abstract: Passive autocatalytic recombiner (PAR) is very useful hydrogen mitigation measurement. It is widely implemented in the current and advanced light water reactors (ALWRs). The design of the PARs should be optimized for the specific use under severe accident scenarios. Several techniques and innovations have been fused into the PAR, as an effort to increase its efficiency of hydrogen mitigation. This study proposes different concepts of PAR, which applied some changes to the honeycomb catalyst PAR made by the Korea Nuclear Technology (KNT) Inc. Two slices of plate are added to the bottom of PAR model, which intended to act as a reflection wall and promote the gas flow into PAR. Hydrogen volume fraction was given 4 vol. % which tested by KNT to investigate the performance of PAR in different direction gas flow conditions to see maximum hydrogen recombination rate. The new concept of PAR was proved to have a better hydrogen removal performance compared to the original honeycomb catalyst PAR.
Special metallurgy - the electrical butt-welding by flashing of sintered magnesium-magnesium oxide composites (1963); Metallurgie speciale - le soudage electrique en bout par etincelage du composite fritte magnesium-magnesie (1963)

Energy Technology Data Exchange (ETDEWEB)

Charleux, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1963-07-01

Electrical resistance welding has become quite important since World War II because of the need of a high yield in aeronautical production. Progress has been due in particular to the improvements made in electronically controlled apparatus making possible the automatic control of welding. For the butt-welding of sections requiring either a high production rate or a high quality weld, the flash butt-welding system has been very much developed these last few years. The use of this welding method is of great importance in the field of the bonding of oxidisable metals such as magnesium or aluminium and its alloys, because the welded joint is free from oxides. This study consists of general considerations on the flash-welding process with regard to temperature distribution in the parts during welding, and to electrical phenomena connected with flashing. Besides this general or theoretical section, we have applied the welding process to the bonding of sintered magnesium, a magnesium-magnesium oxide composite, whose use as a structural element in nuclear reactors is considered. (author) [French] Le soudage electrique par resistance a pris un essor important depuis la derniere guerre mondiale a cause du besoin de haut rendement pour la production aeronautique. Les progres ont ete possibles surtout par l'amelioration des appareils de commande electronique qui permettent un controle automatique de la soudure. Pour le soudage bout a bout de profiles, demandant soit un haut debit de fabrication, soit une haute qualite du joint soude, le procede de soudage en bout par etincelage a ete tres developpe ces dernieres annees. Ce mode de soudage a un domaine d'utilisation important dans la liaison des metaux oxydables tels le magnesium ou l'aluminium et ses alliages, du fait de la proprete du joint soude exempt d'oxydes. Cette etude comporte une consideration generale du processus de l'etincelage, quant a la repartition de la temperature dans les pieces pendant le soudage et aux
Special metallurgy - the electrical butt-welding by flashing of sintered magnesium-magnesium oxide composites (1963); Metallurgie speciale - le soudage electrique en bout par etincelage du composite fritte magnesium-magnesie (1963)

Energy Technology Data Exchange (ETDEWEB)

Charleux, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1963-07-01

Electrical resistance welding has become quite important since World War II because of the need of a high yield in aeronautical production. Progress has been due in particular to the improvements made in electronically controlled apparatus making possible the automatic control of welding. For the butt-welding of sections requiring either a high production rate or a high quality weld, the flash butt-welding system has been very much developed these last few years. The use of this welding method is of great importance in the field of the bonding of oxidisable metals such as magnesium or aluminium and its alloys, because the welded joint is free from oxides. This study consists of general considerations on the flash-welding process with regard to temperature distribution in the parts during welding, and to electrical phenomena connected with flashing. Besides this general or theoretical section, we have applied the welding process to the bonding of sintered magnesium, a magnesium-magnesium oxide composite, whose use as a structural element in nuclear reactors is considered. (author) [French] Le soudage electrique par resistance a pris un essor important depuis la derniere guerre mondiale a cause du besoin de haut rendement pour la production aeronautique. Les progres ont ete possibles surtout par l'amelioration des appareils de commande electronique qui permettent un controle automatique de la soudure. Pour le soudage bout a bout de profiles, demandant soit un haut debit de fabrication, soit une haute qualite du joint soude, le procede de soudage en bout par etincelage a ete tres developpe ces dernieres annees. Ce mode de soudage a un domaine d'utilisation important dans la liaison des metaux oxydables tels le magnesium ou l'aluminium et ses alliages, du fait de la proprete du joint soude exempt d'oxydes. Cette etude comporte une consideration generale du processus de l'etincelage, quant a la repartition de la temperature dans les pieces

Par Pond Fish, Water, and Sediment Chemistry

International Nuclear Information System (INIS)

Paller, M.H.; Wike, L.D.

1996-06-01

The objectives of this report are to describe the Par Pond fish community and the impact of the drawdown and refill on the community, describe contaminant levels in Par Pond fish, sediments, and water and indicate how contaminant concentrations and distributions were affected by the drawdown and refill, and predict possible effects of future water level fluctuations in Par Pond
Par Pond Fish, Water, and Sediment Chemistry

Energy Technology Data Exchange (ETDEWEB)

Paller, M.H. [Westinghouse Savannah River Company, AIKEN, SC (United States); Wike, L.D.

1996-06-01

The objectives of this report are to describe the Par Pond fish community and the impact of the drawdown and refill on the community, describe contaminant levels in Par Pond fish, sediments, and water and indicate how contaminant concentrations and distributions were affected by the drawdown and refill, and predict possible effects of future water level fluctuations in Par Pond.
Concerning the dynamic instability of actin homolog ParM

International Nuclear Information System (INIS)

Popp, David; Yamamoto, Akihiro; Iwasa, Mitsusada; Narita, Akihiro; Maeda, Kayo; Maeda, Yuichiro

2007-01-01

Using in vitro TIRF- and electron-microscopy, we reinvestigated the dynamics of native ParM, a prokaryotic DNA segregation protein and actin homolog. In contrast to a previous study, which used a cysteine ParM mutant, we find that the polymerization process of wild type ATP-ParM filaments consists of a polymerization phase and a subsequent steady state phase, which is dynamically unstable, like that of microtubules. We find that the apparent bidirectional polymerization of ParM, is not due to the intrinsic nature of this filament, but results from ParM forming randomly oriented bundles in the presence of crowding agents. Our results imply, that in the bacterium, ParM filaments spontaneously form bipolar bundles. Due to their intrinsic dynamic instability, ParM bundles can efficiently 'search' the cytoplasmic lumen for DNA, bind it equally well at the bipolar ends and segregate it approximately symmetrically, by the insertion of ParM subunits at either end
First-in-human uPAR PET

DEFF Research Database (Denmark)

Persson, Morten; Skovgaard, Dorthe; Brandt-Larsen, Malene

2015-01-01

A first-in-human clinical trial with Positron Emission Tomography (PET) imaging of the urokinase-type plasminogen activator receptor (uPAR) in patients with breast, prostate and bladder cancer, is described. uPAR is expressed in many types of human cancers and the expression is predictive...... for targeted molecular imaging with PET. The safety, pharmacokinetic, biodistribution profile and radiation dosimetry after a single intravenous dose of (64)Cu-DOTA-AE105 were assessed by serial PET and computed tomography (CT) in 4 prostate, 3 breast and 3 bladder cancer patients. Safety assessment...... of invasion, metastasis and indicates poor prognosis. uPAR PET imaging therefore holds promise to be a new and innovative method for improved cancer diagnosis, staging and individual risk stratification. The uPAR specific peptide AE105 was conjugated to the macrocyclic chelator DOTA and labeled with (64)Cu...
uPAR as anti-cancer target

DEFF Research Database (Denmark)

Lund, Ida K; Illemann, Martin; Thurison, Tine

2011-01-01

, and a potential diagnostic and predictive impact of the different uPAR forms has been reported. Hence, pericellular proteolysis seems to be a suitable target for anti-cancer therapy and numerous approaches have been pursued. Targeting of this process may be achieved by preventing the binding of uPA to u...... using mouse monoclonal antibodies (mAbs) against mouse uPA or uPAR. These reagents will target uPA and uPAR in both stromal cells and cancer cells, and their therapeutic potential can now be assessed in syngenic mouse cancer models....
The Role of Exponential and PCTR Experiments at Hanford in the Design of Large Power Reactors; Roles Respectifs des Experiences Exponentielles et du Reacteur d'Etude des Constantes Physiques de Hanford dans les Etudes de Grands Reacteurs de Puissance; Znachenie ehksponentsial'nykh opytov i opytov na reaktore PCTR pri proektirovanii bol'shikh ehnergeticheskikh reaktorov v khehnforde; Papel de los Experimentos Exponenciales y del Reactor PCTR de Hanford en el Proyecto de Grandes Reactores de Potencia

Energy Technology Data Exchange (ETDEWEB)

Heineman, R. E. [General Electric Company, Richland, WA (United States)

1964-02-15

use is described in the light of the trends which are observed. (author) [French] Des mesures exponentielles sont faites aux laboratoires de Hanford sur des reseaux uranium-graphite depuis pres de quinze ans. Les resultats de ces experiences ont ete utilises pour determiner les laplaciens de reacteurs de production que l'on se proposait de construire, mais ils ont servi egalement a ameliorer les connaissances dans le domaine de la physique de ces systemes. On s'est rendu compte tres rapidement qu'en raison des dimensions des assemblages et de leur manque de sensibilite aux petites perturbations localisees du systeme, l'experience exponentielle n'a qu'une utilite limitee. On a donc envisage de mettre au point des experiences integrales avec un reacteur de maniere a reduire au minimum la quantite de matieres necessaires pour se procurer des donnees valables. A cet effet, on a construit une installation critique perfectionnee a plusieurs regions, qu'on a appelee 'reacteur d'etude des constantes physiques' (RECP), dont on s'est servi pour determiner les constantes physiques de plusieurs reacteurs de puissance. On s'en est servi aussi couramment pour mesurer des sections efficaces et determiner des parametres differentiels et integraux de la physique des reacteurs pour divers types de milieux multiplicateurs. Apres la construction de RECP, on a encore employe les experiences exponentielles, bien que RECP ait largement comble les espoirs qui avaient ete places en lui. L'auteur indique quelques donnees caracteristiques obtenues a l'aide de ces deux genres d'installations et compare leurs roles respectifs pour l'etude de nouveaux reacteurs de puissance, pour la modification de reacteurs en fonctionnement, comme moyens de recherche sur la physique des reacteurs et comme moyen de formation. Il compare egalement les montants des capitaux investis dans ces installations et des frais de fonctionnement. Il indique comment ont ete mises au point de nouvelles methodes experimentales
Contribution to the study of point defects formed in nickel by electron bombardment; Contribution a l'etude des defauts ponctuels crees par bombardement electronique dans le nickel

Energy Technology Data Exchange (ETDEWEB)

Oddou, J L [Commissariat a l' Energie Atomique, 38 - Grenoble (France). Centre d' Etudes Nucleaires

1968-12-01

After a short account of the experimental techniques employed in our studies, the experimental results obtained on pure nickel samples are exposed. The apparition of the successive annihilation stages of point defects created by electron bombardment is established by isochronal heat treatments: the annihilation kinetics and the corresponding activation energies are determined. The effect of the incident particle doses is also studied. The experimental results are then compared with R.A. Johnson's theoretical calculations of the stability and the migration of point defects in nickel, and taking into account the results obtained by Peretto in magnetic after effect measurements. This leads us to a model in good agreement with calculations and experiment for the first stages. In a second chapter the behaviour of nickel doped by certain impurities is studied. First, the results concerning the rate of increase of resistivity (function of sample purity) is investigated. Two possible explanations of the observed phenomenon are proposed: either a deviation with respect to Mathiessen's law, or an increase of the number of defects formed in the presence of impurity atoms. Finally, a study of the resistivity recovery of the doped samples permits us to suggest an order of magnitude for the binding energy interstitial/impurity atom in the nickel matrix. (author) [French] Apres avoir brievement rappele les techniques experimentales que nous avons utilisees pour cette etude, nous exposons les resultats experimentaux obtenus sur des echantillons de nickel pur. Les stades successifs d'annihilation des defauts ponctuels crees par bombardement electronique sont mis en evidence par traitements thermiques isochrones; les cinetiques de disparition, et les energies d'activation correspondantes sont determinees. Nous etudions egalement l'effet de la dose des particules incidentes. Les resultats experimentaux sont ensuite compares avec les calculs theoriques de R.A JOHNSON sur la stabilite
Protease-activated receptor (PAR2, but not PAR1, is involved in collateral formation and anti-inflammatory monocyte polarization in a mouse hind limb ischemia model.

Directory of Open Access Journals (Sweden)

Lisa G van den Hengel

Full Text Available AIMS: In collateral development (i.e. arteriogenesis, mononuclear cells are important and exist as a heterogeneous population consisting of pro-inflammatory and anti-inflammatory/repair-associated cells. Protease-activated receptor (PAR1 and PAR2 are G-protein-coupled receptors that are both expressed by mononuclear cells and are involved in pro-inflammatory reactions, while PAR2 also plays a role in repair-associated responses. Here, we investigated the physiological role of PAR1 and PAR2 in arteriogenesis in a murine hind limb ischemia model. METHODS AND RESULTS: PAR1-deficient (PAR1-/-, PAR2-deficient (PAR2-/- and wild-type (WT mice underwent femoral artery ligation. Laser Doppler measurements revealed reduced post-ischemic blood flow recovery in PAR2-/- hind limbs when compared to WT, while PAR1-/- mice were not affected. Upon ischemia, reduced numbers of smooth muscle actin (SMA-positive collaterals and CD31-positive capillaries were found in PAR2-/- mice when compared to WT mice, whereas these parameters in PAR1-/- mice did not differ from WT mice. The pool of circulating repair-associated (Ly6C-low monocytes and the number of repair-associated (CD206-positive macrophages surrounding collaterals in the hind limbs were increased in WT and PAR1-/- mice, but unaffected in PAR2-/- mice. The number of repair-associated macrophages in PAR2-/- hind limbs correlated with CD11b- and CD115-expression on the circulating monocytes in these animals, suggesting that monocyte extravasation and M-CSF-dependent differentiation into repair-associated cells are hampered. CONCLUSION: PAR2, but not PAR1, is involved in arteriogenesis and promotes the repair-associated response in ischemic tissues. Therefore, PAR2 potentially forms a new pro-arteriogenic target in coronary artery disease (CAD patients.
Apoplejía pituitaria con parálisis del III par craneal: Reporte de caso

Directory of Open Access Journals (Sweden)

Miguel Pinto Valdivia

2011-10-01

Full Text Available Se describe el caso de un varón de 65 años de edad, sin antecedentes patológicos de importancia, que acudió a emergencia del Hospital Nacional Cayetano Heredia por presentar cefalea intensa y ptosis palpebral izquierda. El examen físico mostró parálisis aislada del III par craneal izquierdo. Los análisis de laboratorio mostraron hiponatremia e hipopituitarismo y la resonancia magnética nuclear un adenoma pituitario con áreas de hemorragia e invasión de los senos cavernosos. El tratamiento incluyó glucocorticoides y descompresión quirúrgica transesfenoidal. La anatomía patológica confirmó el diagnóstico de infarto hemorrágico de un adenoma pituitario. El paciente fue dado de alta con terapia sustitutiva de levotiroxina y prednisona. La ptosis palpebral izquierda se recuperó en forma parcial. La apoplejía pituitaria es un síndrome clínico producido por un proceso expansivo dentro de la silla turca, secundario a hemorragia o infarto de un adenoma pituitario, que se caracteriza por cefalea, déficit visual, oftalmoplejía y alteración del nivel de conciencia. Este proceso expansivo puede comprimir los pares craneales en los senos cavernosos, produciendo diferentes grados de parálisis de los músculos oculomotores. La parálisis aislada del III par craneal es rara.(Rev Med Hered 2011;22:186-189.
Copenhagen uPAR prostate cancer (CuPCa) database

DEFF Research Database (Denmark)

Lippert, Solvej; Berg, Kasper D; Høyer-Hansen, Gunilla

2016-01-01

AIM: Urokinase plasminogen activator receptor (uPAR) plays a central role during cancer invasion by facilitating pericellular proteolysis. We initiated the prospective 'Copenhagen uPAR Prostate Cancer' study to investigate the significance of uPAR levels in prostate cancer (PCa) patients. METHODS...
Recombination in the human Pseudoautosomal region PAR1.

Directory of Open Access Journals (Sweden)

Anjali G Hinch

2014-07-01

Full Text Available The pseudoautosomal region (PAR is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and PAR deletion results in male sterility. This leads the human PAR with the obligatory crossover, PAR1, to having an exceptionally high male crossover rate, which is 17-fold higher than the genome-wide average. However, the mechanism by which this obligatory crossover occurs remains unknown, as does the fine-scale positioning of crossovers across this region. Recent research in mice has suggested that crossovers in PAR may be mediated independently of the protein PRDM9, which localises virtually all crossovers in the autosomes. To investigate recombination in this region, we construct the most fine-scale genetic map containing directly observed crossovers to date using African-American pedigrees. We leverage recombination rates inferred from the breakdown of linkage disequilibrium in human populations and investigate the signatures of DNA evolution due to recombination. Further, we identify direct PRDM9 binding sites using ChIP-seq in human cells. Using these independent lines of evidence, we show that, in contrast with mouse, PRDM9 does localise peaks of recombination in the human PAR1. We find that recombination is a far more rapid and intense driver of sequence evolution in PAR1 than it is on the autosomes. We also show that PAR1 hotspot activities differ significantly among human populations. Finally, we find evidence that PAR1 hotspot positions have changed between human and chimpanzee, with no evidence of sharing among the hottest hotspots. We anticipate that the genetic maps built and validated in this work will aid research on this vital and fascinating region of the genome.
Plasma suPAR is lowered by smoking cessation

DEFF Research Database (Denmark)

Eugen-Olsen, Jesper; Ladelund, Steen; Sørensen, Lars Tue

2016-01-01

BACKGROUND: Soluble urokinase plasminogen activator receptor (suPAR) is a stable inflammatory biomarker. In patients, suPAR is a marker of disease presence, severity and prognosis. In the general population, suPAR is predictive of disease development, such as diabetes and cardiovascular disease a...
Effects of hydrogen on the tensile strength characteristics of stainless steels; Effets de l'hydrogene sur les caracteristiques de rupture par traction d'aciers inoxydables

Energy Technology Data Exchange (ETDEWEB)

Blanchard, R; Pelissier, J; Pluchery, M [Commissariat a l' Energie Atomique, Grenoble (France).Centre d' Etudes Nucleaires; Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

1961-07-01

This paper deals with the effects of hydrogen on stainless steel, that might possibly be used as a canning material in hydrogen-cooled reactors. Apparent ultimate-tensile strength is only 80 per cent of initial value for hydrogen content about 50 cc NTP/ 100 g, and reduction in area decreases from 80 to 55 per cent. A special two-stage replica technique has been developed which allows fracture surface of small tensile specimens (about 0.1 mm diam.) to be examined in an electron microscope. All the specimens showed evidence of ductile character throughout the range of hydrogen contents investigated, but the aspect of the fracture surfaces gradually changes with increasing amounts. (author) [French] On etudie les effets de l'hydrogene sur des aciers inoxydables, qui sont des materiaux de gainage possibles pour des reacteurs utilisant l'hydrogene comme gaz de refroidissement. On montre que la charge apparente de rupture a la traction n'est plus que 80 pour cent de sa valeur initiale lorsque la teneur en hydrogene atteint 50 cc TPN/ 100 g, et que la striction passe dans ces conditions de 80 a 55 pour cent. L'examen microfractographique qui a ete effectue avec succes par une technique de double replique malgre la petitesse des echantillons (0,3 mm de diametre environ), revele que tout en gardant un caractere ductile, l'aspect des surfaces de rupture evolue notablement avec la teneur en hydrogene. (auteur)
Improvements to the properties of uranium by addition of small quantities of other metals; Ameliorations apportees a l'uranium par de faibles additions metalliques

Energy Technology Data Exchange (ETDEWEB)

Englander, M [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

1960-07-01

The most economical nuclear fuel used in power reaction which produce energy for industrial purposes is metallic uranium, either in natural form or slightly enriched in the {sup 235}U isotope. Under optimum working conditions any fuel should produce a minimum of 3,000 MW days/tonne, i.e. 72 x 10{sup 6} kWh per tonne of natural uranium, while at the same lime being maintained at a temperature sufficiently high for it to fulfil its role of heat-source (at a minimum of between 350 and 550 deg. C). Now it is rather surprising to note that polycrystalline aggregates in uranium billets, obtained either by casting under vacuum or by extrusion at high temperature, are made up of course grains having broken-up, irregular contours and exhibit numerous signs of intergranular deformation (twin crystals, slip-lines) as well as a pronounced sub-structure. As well as this, the range of grain diameters extends from a few microns up to a few millimeters, according to the micrographic zones examined. Under the influence of irradiation at these temperatures, pure cylindrical metallic uranium bars of about 1 inch diameter are deformed: cracks appear in the metal and changes in the length and diameter occur (these produce an 'orange-peel' texture on the surface). These changes are caused either by growths which are more or less oriented, or else by surface distortions which can cause faults in the material and in the canning and can produce bending which may be sufficiently pronounced to interfere with the cooling circuits. It has since been realised that this instability under the effects of thermal stresses of nuclear origin is due to the heterogeneous morphology of uranium and to its anisotropic crystalline structure (U{sub {alpha}} or U{sub {beta}}). (author) [French] Les reacteurs de puissance destines a fournir l'energie industriellement recuperable utilisent comme materiau combustible nucleaire le plus economique, l'uranium metallique naturel ou legerement enrichi en isotope U
Alize 3 - first critical experiment for the franco-german high flux reactor - calculations; Alize 3 - premiere experience critique pour le reacteur a haut flux franco-allemand. Calculs

Energy Technology Data Exchange (ETDEWEB)

Scharmer, K [Commissariat a l' Energie Atomique, Dir. des Piles Atomiques, Saclay (France). Centre d' Etudes Nucleaires

1969-07-01

The results of experiments in the light water cooled D{sub 2}O reflected critical assembly ALIZE III have been compared to calculations. A diffusion model was used with 3 fast and epithermal groups and two overlapping thermal groups, which leads to good agreement of calculated and measured power maps, even in the case of strong variations of the neutron spectrum in the core. The difference of calculated and measured k{sub eff} was smaller than 0.5 per cent {delta}k/k. Calculations of void and structure material coefficients of the reactivity of 'black' rods in the reflector, of spectrum variations (Cd-ratio, Pu-U-ratio) and to the delayed photoneutron fraction in the D{sub 2}O reflector were made. Measurements of the influence of beam tubes on reactivity and flux distribution in the reflector were interpreted with regard to an optimum beam tube arrangement for the Franco- German High Flux Reactor. (author) [French] Les resultats des experiences faites dans la maquette critique ALIZE III, refrigeree a l'eau legere et reflechie par l'eau lourde, ont ete compares aux calculs. On a utilise un modele de la theorie de diffusion a trois groupes rapides et epithermiques et deux groupes thermiques qui se recouvrent. Ce modele a permis de calculer la distribution de puissance dans le coeur en bon accord avec les mesures, meme dans le cas d'une forte variation du spectre des neutrons dans le coeur. L'erreur entre k{sub eff} calcule et mesure etait inferieure a 0,5 pour cent {delta}k/k. Le coefficient de vide et des materiaux de structure, la reactivite des barres 'noires', les variations du spectre (rapport Cd, rapport Pu/U) et la fraction des photo-neutrons retardes sont egalement calcules. Les mesures de reactivite et de perturbation de flux dans le reflecteur, dues aux canaux, ont ete interpretees du point de vue d'un arrangement optimum des canaux pour le Reacteur a Haut Flux Franco-Allemand. (auteur)
Developpement D'un Modele Climatique Regional: Fizr Simulation des Conditions de Janvier de la Cote Ouest Nord Americaine

Science.gov (United States)

Goyette, Stephane

1995-11-01

Le sujet de cette these concerne la modelisation numerique du climat regional. L'objectif principal de l'exercice est de developper un modele climatique regional ayant les capacites de simuler des phenomenes de meso-echelle spatiale. Notre domaine d'etude se situe sur la Cote Ouest nord americaine. Ce dernier a retenu notre attention a cause de la complexite du relief et de son controle sur le climat. Les raisons qui motivent cette etude sont multiples: d'une part, nous ne pouvons pas augmenter, en pratique, la faible resolution spatiale des modeles de la circulation generale de l'atmosphere (MCG) sans augmenter a outrance les couts d'integration et, d'autre part, la gestion de l'environnement exige de plus en plus de donnees climatiques regionales determinees avec une meilleure resolution spatiale. Jusqu'alors, les MCG constituaient les modeles les plus estimes pour leurs aptitudes a simuler le climat ainsi que les changements climatiques mondiaux. Toutefois, les phenomenes climatiques de fine echelle echappent encore aux MCG a cause de leur faible resolution spatiale. De plus, les repercussions socio-economiques des modifications possibles des climats sont etroitement liees a des phenomenes imperceptibles par les MCG actuels. Afin de circonvenir certains problemes inherents a la resolution, une approche pratique vise a prendre un domaine spatial limite d'un MCG et a y imbriquer un autre modele numerique possedant, lui, un maillage de haute resolution spatiale. Ce processus d'imbrication implique alors une nouvelle simulation numerique. Cette "retro-simulation" est guidee dans le domaine restreint a partir de pieces d'informations fournies par le MCG et forcee par des mecanismes pris en charge uniquement par le modele imbrique. Ainsi, afin de raffiner la precision spatiale des previsions climatiques de grande echelle, nous developpons ici un modele numerique appele FIZR, permettant d'obtenir de l'information climatique regionale valide a la fine echelle spatiale
The inflammatory marker suPAR after cardiac arrest

DEFF Research Database (Denmark)

Rundgren, Malin; Lyngbaek, Stig; Fisker, Helle

2015-01-01

. This pilot study aimed at investigating suPAR levels in relation to outcome after CA and mild induced hypothermia. METHODS: suPAR levels were measured at 6, 36, and 72 hours in patients treated with hypothermia after CA. suPAR levels were analyzed in relation to survival after 6 months. Receiver operating...
Study of the strength of the internal can for internally and externally cooled fuel elements intended for gas graphite reactors; Etude de la tenue de la gaine interne pour-element combustible a refroidissement interne et externe d'un reacteur graphite-gaz

Energy Technology Data Exchange (ETDEWEB)

Boudouresque, B; Courcon, P; Lestiboubois, G [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

The cartridge of an internally and externally cooled annular fuel element used in gas-graphite reactors is made up of an uranium fuel tube, an external can and an internal can made of magnesium alloy. For the thermal exchange between the internal can and the fuel to be satisfactory, it is necessary for the can to stay in contact with the uranium under all temperature conditions. This report, based on a theoretical study, shows how the internal can fuel gap varies during the processes of canning, charging into the reactor and thermal cycling. The following parameters are considered: tube diameter, pressure of the heat carrying gas, gas entry temperature, plasticity of the can alloy. It is shown that for all operating conditions the internal can of a 77 x 95 element, planned for a gas-graphite reactor with a 40 kg/cm{sup 2} gas pressure, should remain in contact with the fuel. (authors) [French] La cartouche d'un element combustible annulaire, a refroidissement interne et externe pour reacteur graphite-gaz, est composee d'un tube combustible en uranium, d'une gaine externe et d'une gaine interne en alliage de magnesium. Pour que l'echange thermique entre la gaine interne et le combustible soit bon, il faut que la gaine reste appliquee sur l'uranium quel que soit le regime de temperature. Cette note a pour but de montrer comment, d'apres une etude theorique, le jeu combustible-gaine interne varie au cours des operations de gainage, de chargement dans le reacteur, et des cyclages thermiques. Les parametres suivants sont etudies: diametres de tube, pression du gaz caloporteur, temperature d'entree du gaz, plasticite de l'alliage de gaine. Il est montre que, quel que soit le regime de fonctionnement, la gaine interne d'un element 77 x 95, en projet pour un reacteur graphite-gaz sous pression de 40 kg/cm{sup 2}, doit rester appliquee sur le combustible. (auteurs)
It's quicker "Par Avignon"!

CERN Multimedia

2005-01-01

For a few years, the CERN Library has been receiving books from the University of Hanover sent via Avignon, at least that's what it says on the envelope. Such a detour would mean that parcels were travelling 720 km more than the distance separating Geneva and Hanover, which would be a very strange state of affairs. The explanation lies in a spelling mistake. The sender has been stamping parcels with a stamp that says "Par Avignon prioritaire" (first-class via Avignon) instead of "Par Avion prioritaire" (First Class Air Mail), a source of much amusement to the librarians!
Serum suPAR in patients with FSGS: trash or treasure?

Science.gov (United States)

Maas, Rutger J H; Deegens, Jeroen K J; Wetzels, Jack F M

2013-07-01

The urokinase-type plasminogen activator receptor (uPAR) has important functions in cell migration. uPAR can be shed from the cell membrane resulting in soluble uPAR (suPAR). Further cleavage gives rise to shorter fragments with largely unknown functions. Recent studies have demonstrated that both overexpression of uPAR on podocytes and the administration of suPAR cause proteinuria in mice. The common pathogenic mechanism involves the activation of podocyte β3-integrin. Increased activation of β3-integrin is also observed in patients with focal and segmental glomerulosclerosis (FSGS). These observations form the basis for the hypothesis that suPAR may be the circulating factor causing FSGS. A recent study fosters this idea by demonstrating increased suPAR levels in the serum of patients with FSGS and reporting an association with recurrence after transplantation and response to plasmapheresis. However, this study was heavily biased, and subsequent studies have given conflicting results. Although the experimental work is very suggestive, at present there is no proof that any known human suPAR fragment causes FSGS in humans. We therefore suggest that the measurement of suPAR using currently available assays has absolutely no value at the present time in decision-making in routine clinical practice.

Proteinase-Activated Receptor 1 (PAR1 regulates leukemic stem cell functions.

Directory of Open Access Journals (Sweden)

Nicole Bäumer

Full Text Available External signals that are mediated by specific receptors determine stem cell fate. The thrombin receptor PAR1 plays an important role in haemostasis, thrombosis and vascular biology, but also in tumor biology and angiogenesis. Its expression and function in hematopoietic stem cells is largely unknown. Here, we analyzed expression and function of PAR1 in primary hematopoietic cells and their leukemic counterparts. AML patients' blast cells expressed much lower levels of PAR1 mRNA and protein than CD34+ progenitor cells. Constitutive Par1-deficiency in adult mice did not affect engraftment or stem cell potential of hematopoietic cells. To model an AML with Par1-deficiency, we retrovirally introduced the oncogene MLL-AF9 in wild type and Par1-/- hematopoietic progenitor cells. Par1-deficiency did not alter initial leukemia development. However, the loss of Par1 enhanced leukemic stem cell function in vitro and in vivo. Re-expression of PAR1 in Par1-/- leukemic stem cells delayed leukemogenesis in vivo. These data indicate that Par1 contributes to leukemic stem cell maintenance.
Proteinase-Activated Receptor 1 (PAR1) regulates leukemic stem cell functions.

Science.gov (United States)

Bäumer, Nicole; Krause, Annika; Köhler, Gabriele; Lettermann, Stephanie; Evers, Georg; Hascher, Antje; Bäumer, Sebastian; Berdel, Wolfgang E; Müller-Tidow, Carsten; Tickenbrock, Lara

2014-01-01

External signals that are mediated by specific receptors determine stem cell fate. The thrombin receptor PAR1 plays an important role in haemostasis, thrombosis and vascular biology, but also in tumor biology and angiogenesis. Its expression and function in hematopoietic stem cells is largely unknown. Here, we analyzed expression and function of PAR1 in primary hematopoietic cells and their leukemic counterparts. AML patients' blast cells expressed much lower levels of PAR1 mRNA and protein than CD34+ progenitor cells. Constitutive Par1-deficiency in adult mice did not affect engraftment or stem cell potential of hematopoietic cells. To model an AML with Par1-deficiency, we retrovirally introduced the oncogene MLL-AF9 in wild type and Par1-/- hematopoietic progenitor cells. Par1-deficiency did not alter initial leukemia development. However, the loss of Par1 enhanced leukemic stem cell function in vitro and in vivo. Re-expression of PAR1 in Par1-/- leukemic stem cells delayed leukemogenesis in vivo. These data indicate that Par1 contributes to leukemic stem cell maintenance.
Serum suPAR in patients with FSGS: trash or treasure?

NARCIS (Netherlands)

Maas, R.J.H.; Deegens, J.K.J.; Wetzels, J.F.M.

2013-01-01

The urokinase-type plasminogen activator receptor (uPAR) has important functions in cell migration. uPAR can be shed from the cell membrane resulting in soluble uPAR (suPAR). Further cleavage gives rise to shorter fragments with largely unknown functions. Recent studies have demonstrated that both
Accouchement par forceps: indications et pronostic materno-foetal ...

African Journals Online (AJOL)

L'accouchement par voie basse, peut être parfois compromis par des facteurs maternels, foetaux ou materno-foetaux nécessitant des moyens thérapeutiques comme le forceps pour achever l'accouchement par voie naturelle. Le forceps, une méthode qui n'est pas sans risque pour la mère et le nouveau-né. Nous avons ...
Syntheses and study of pyrrolidinic nitroxide free radicals. Preparation of a nitroxide-type stable bi-radical; Synthese et etudes de radicaux libres nitroxydes pyrrolidiniques. Preparation d'un biradical stable du type nitroxyde

Energy Technology Data Exchange (ETDEWEB)

Dupeyre, R M [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires, Laboratoire de chimie organique physique

1967-12-01

Syntheses and study of pyrrolidinic nitroxide free radicals: These radicals are obtained by oxidation, with hydrogen peroxide, of pyrrolidinic amines prepared from triacetonamine by ring contraction. The U. V,, I. R, and E.P.R. spectral characteristics have been determined. The oxidation of these amines with hydrogen peroxide has led also to rupture of the pentagonal ring; some of the decomposition products have been identified. The high chemical stability of the nitroxide group has made it possible to synthesize and study a stable bi-radical. (author) [French] Syntheses et etudes de radicaux libres nitroxydes pyrrolidiniques: Ces radicaux sont obtenus par oxydation l'eau oxygenee d'amines pyrrolidiniques preparees a partir de la triacetonamine par contraction de cycle. Les caracteristiques spectroscopiques ultra-violettes, infra-rouge et resonance paramagnetique sont determinees. Cependant, 1'oxydation de ces amines a l'eau oxygenee a entraine la coupure du cycle pentagonal et identification de certaines substances de decomposition obtenues. La grande stabilite chimique de groupement nitroxyde a permis la synthese et l'etude d'un biradical stable. (auteur)
Protease-Activated Receptor 4 (PAR4): A Promising Target for Antiplatelet Therapy.

Science.gov (United States)

Rwibasira Rudinga, Gamariel; Khan, Ghulam Jilany; Kong, Yi

2018-02-14

Cardiovascular diseases (CVDs) are currently among the leading causes of death worldwide. Platelet aggregation is a key cellular component of arterial thrombi and major cause of CVDs. Protease-activated receptors (PARs), including PAR1, PAR2, PAR3 and PAR4, fall within a subfamily of seven-transmembrane G-protein-coupled receptors (GPCR). Human platelets express PAR1 and PAR4, which contribute to the signaling transduction processes. In association with CVDs, PAR4 not only contributes to platelet activation but also is a modulator of cellular responses that serve as hallmarks of inflammation. Although several antiplatelet drugs are available on the market, they have many side effects that limit their use. Emerging evidence shows that PAR4 targeting is a safer strategy for preventing thrombosis and consequently may improve the overall cardiac safety profile. Our present review summarizes the PAR4 structural characteristics, activation mechanism, role in the pathophysiology of diseases and understanding the association of PAR4 targeting for improved cardiac protection. Conclusively, this review highlights the importance of PAR4 antagonists and its potential utility in different CVDs.
Measurement of the absolute values of cross-sections in neutron photoproduction (1962); Mesure de sections efficaces de photoproduction de neutrons en valeur absolue (1962)

Energy Technology Data Exchange (ETDEWEB)

Schuhl, C [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1962-07-01

The absolute values of photoneutrons production cross-sections for the case of intermediate and heavy nuclei (lanthanium, cerium, tantalum, gold, lead and bismuth) are determined with an error of 15 per cent. The results obtained agree with theories in which the giant resonance is explained by the collective motion of the protons against the neutrons. The effect of the nuclear deformation on the shape of the giant resonance is seen in the case of Ta{sup 181}, it will be possible to determine the quadrupole momenta of deformed nuclei with a good accuracy when we shall increase the statistics of measurements. (author) [French] Les sections efficaces de production de photoneutrons par divers noyaux moyens et lourds (lanthane, cerium, tantale, or, plomb et bismuth) sont determinees en valeur absolue avec une erreur relative de 15 pour cent. Les resultats obtenus s'accordent avec les theories qui interpretent la resonance geante par un mouvement collectif des protons par rapport aux neutrons. L'influence de la deformation du noyau sur la forme de la resonance geante est soulignee dans le cas de {sup 181}Ta pour lequel elle se decompose en deux pics. Une amelioration de la statistique des mesures permettra de determiner les moments quadrupolaires des noyaux deformes avec une meilleure precision. (auteur)
Major accident analyses for experimental zero-power fast reactor assemblies; Analyse des accidents graves pouvant survenir dans les reacteurs experimentaux a neutrons rapides de puissance zero; Analiz krupnoj avarii dlya ehksperimental'ny kh reaktornykh ustanovok nulevoj moshchnosti na bystrykh nejtronakh; Analisis de los accidentes graves que pueden producirse en los reactores experimentales rapidos de potencia cero

Energy Technology Data Exchange (ETDEWEB)

Fischer, G.; Barts, E. W.; Kapil, S.; Tomabechi, K. [Argonne National Laboratory, Argonne, IL (United States)

1962-03-15

systems with the very soft neutron-energy spectra characteristic of large oxide power breeders. (author) [French] Les auteurs ont etudie la possibilite, le mecanisme et les consequences de la fusion et autres accidents nucleaires graves dans les reacteurs experimentaux a neutrons rapides de puissance zero, du type ZPR-III, a coeur divise. Cette etude a ete completee par une evaluation de l'importance de l'effet Doppler sur un grand nombre de reacteurs de ce type. Les auteurs demontrent qu'il est fort peu probable qu'une fusion se produise, du fait que la conjonction des circonstances qui pourraient la provoquer est difficilement realisable. L'expose du mecanisme de fusion est suivi de l'analyse des resultats de calculs couples neutronique-hydrodynamiqu e relatifs a deux reacteurs de puissance zero. On a choisi pour cette etude un coeur de 1200 l, qui correspond a un reacteur relativement grand a coeur normal. L'etude a egalement porte sur un coeur plus petit ayant un coefficient cavitaire plus important, qui pourrait presenter un plus grand danger. Chaque systeme a eu un comportement en fonction du temps tout a fait different. Si un accident grave survient dans un reacteur de puissance zero, les atomes de {sup 235}U, isoles dans les plaques d'uranium enrichi, s'echauffen t tres rapidement tandis que le reste du coeur demeure pratiquement froid; il y a ainsi formation d'un gaz du {sup 235}U qui donne lieu a la pression de rupture. Les auteurs expliquent l'adaptation qu'ils ont faite du code AX-I de neutronique-hydrodynamiqu e pour l'appliquer a un gaz de Van der Waals. Une autre modification importante de l'equation d'etat utilisee dans ce code consiste a employer une equation du type Mie-Grueneisen, derivee de la theorie de l'etat solide. Cette modification permet d'evaluer de facon plus satis- faisante le terme de pression pour les coeurs de composition variable. Du fait que les plaques en uranium fortement enrichi d'un reacteur de puissance zero s'echauffent plus
PAR1 activation affects the neurotrophic properties of Schwann cells.

Science.gov (United States)

Pompili, Elena; Fabrizi, Cinzia; Somma, Francesca; Correani, Virginia; Maras, Bruno; Schininà, Maria Eugenia; Ciraci, Viviana; Artico, Marco; Fornai, Francesco; Fumagalli, Lorenzo

2017-03-01

Protease-activated receptor-1 (PAR1) is the prototypic member of a family of four G-protein-coupled receptors that signal in response to extracellular proteases. In the peripheral nervous system, the expression and/or the role of PARs are still poorly investigated. High PAR1 mRNA expression was found in the rat dorsal root ganglia and the signal intensity of PAR1 mRNA increased in response to sciatic nerve transection. In the sciatic nerve, functional PAR1 receptor was reported at the level of non-compacted Schwann cell myelin microvilli of the nodes of Ranvier. Schwann cells are the principal population of glial cells of the peripheral nervous system which myelinate axons playing an important role during axonal regeneration and remyelination. The present study was undertaken in order to determine if the activation of PAR1 affects the neurotrophic properties of Schwann cells. Our results suggest that the stimulation of PAR1 could potentiate the Schwann cell ability to favour nerve regeneration. In fact, the conditioned medium obtained from Schwann cell cultures challenged with a specific PAR1 activating peptide (PAR1 AP) displays increased neuroprotective and neurotrophic properties with respect to the culture medium from untreated Schwann cells. The proteomic analysis of secreted proteins in untreated and PAR1 AP-treated Schwann cells allowed the identification of factors differentially expressed in the two samples. Some of them (such as macrophage migration inhibitory factor, matrix metalloproteinase-2, decorin, syndecan 4, complement C1r subcomponent, angiogenic factor with G patch and FHA domains 1) appear to be transcriptionally regulated after PAR1 AP treatment as shown by RT-PCR. Copyright © 2017 Elsevier Inc. All rights reserved.
Protease-Activated Receptor 4 (PAR4: A Promising Target for Antiplatelet Therapy

Directory of Open Access Journals (Sweden)

Gamariel Rwibasira Rudinga

2018-02-01

Full Text Available Cardiovascular diseases (CVDs are currently among the leading causes of death worldwide. Platelet aggregation is a key cellular component of arterial thrombi and major cause of CVDs. Protease-activated receptors (PARs, including PAR1, PAR2, PAR3 and PAR4, fall within a subfamily of seven-transmembrane G-protein-coupled receptors (GPCR. Human platelets express PAR1 and PAR4, which contribute to the signaling transduction processes. In association with CVDs, PAR4 not only contributes to platelet activation but also is a modulator of cellular responses that serve as hallmarks of inflammation. Although several antiplatelet drugs are available on the market, they have many side effects that limit their use. Emerging evidence shows that PAR4 targeting is a safer strategy for preventing thrombosis and consequently may improve the overall cardiac safety profile. Our present review summarizes the PAR4 structural characteristics, activation mechanism, role in the pathophysiology of diseases and understanding the association of PAR4 targeting for improved cardiac protection. Conclusively, this review highlights the importance of PAR4 antagonists and its potential utility in different CVDs.
Vote par sondage uniforme incorruptible

OpenAIRE

Blanchard , Nicolas

2016-01-01

International audience; Introduit en 2012 par David Chaum, le vote par sondage uniforme (random-sample voting) est un protocole de vote basé sur un choix d'une sous-population représentative , permettant de limiter les coûts tout en ayant de nombreux avantages, principalement lorsqu'il est couplé a d'autres techniques comme ThreeBallot. Nous analysons un problème de corruptibilité potentielle où les votants peuvent vendre leur vote au plus offrant et proposons une variation du protocole reméd...
The double par locus of virulence factor pB171: DNA segregation is correlated with oscillation of ParA

DEFF Research Database (Denmark)

Ebersbach, G; Gerdes, K; Charbon, Gitte Ebersbach

2001-01-01

Prokaryotic plasmids and chromosomes encode partitioning (par) loci that segregate DNA to daughter cells before cell division. Recent database analyses showed that almost all known par loci encode an ATPase and a DNA-binding protein, and one or more cis-acting regions where the proteins act. All...
The role of pars flaccida in human middle ear sound transmission.

Science.gov (United States)

Aritomo, H; Goode, R L; Gonzalez, J

1988-04-01

The role of the pars flaccida in middle ear sound transmission was studied with the use of twelve otoscopically normal, fresh, human temporal bones. Peak-to-peak umbo displacement in response to a constant sound pressure level at the tympanic membrane was measured with a noncontacting video measuring system capable of repeatable measurements down to 0.2 micron. Measurements were made before and after pars flaccida modifications at 18 frequencies between 100 and 4000 Hz. Four pars flaccida modifications were studied: (1) acoustic insulation of the pars flaccida to the ear canal with a silicone rubber baffle, (2) stiffening the pars flaccida with cyanoacrylate cement, (3) decreasing the tension of the pars flaccida with a nonperforating incision, and (4) perforation of the pars flaccida. All of the modifications (except the perforation) had a minimal effect on umbo displacement; this seems to imply that the pars flaccida has a minor acoustic role in human beings.
Study by photo-ionization of some simple poly-atomic molecules and calculation of the Franck-Condon factors; Etude par photo-ionization de quelques molecules poly-atomiques simples et calcul des facteurs de Franck-Condon

Energy Technology Data Exchange (ETDEWEB)

Botter, R [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1968-02-01

'ionisation, ou facteurs de Franck-Condon, ont ete calculees pour C{sub 2}H{sub 2} et C{sub 2}D{sub 2} a l'aide de la methode developpee par Sharp et Rosenstock. L'accord obtenu entre les valeurs calculees et celles determinees experimentalement a partir des courbes de rendement de photoionisation est generalement bon. Nous avons ensuite etendu la methode de calcul precedente au cas ou la transition electronique a lieu avec variation de structure geometrique de la molecule (en particulier changement de symetrie). Les facteurs de Franck- Condon ont ete determines pour NH{sub 3} (variation de symetrie) et pour H{sub 2}O (variation d'angle a l'equilibre). Le calcul montre que l'excitation des bandes de combinaison est generalement importante. (auteur)
Preliminary studies of vanadium-base alloys intended for use in fabrication of cans for fast reactors; Etudes preliminaires sur les alliages a base de vanadium envisages pour la fabrication de gaines de reacteurs rapides

Energy Technology Data Exchange (ETDEWEB)

Conte, M [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

1967-03-15

Preliminary research has been carried out on a series of vanadium-based alloys: V, 0.5 per cent Si; V, 5 per cent Ca; V, 5 per cent Mo; V, 5 per cent Nb; V, 2 per cent Zr; V, 20 per cent Ti; V, 10 per cent Al; V, 10 per cent Sn and v, 10 per cent Ti liable to be used as canning material in fast reactors. The transformation by forging at about 1000 deg. C and rolling between 200 deg. C and room temperature is satisfactory for all types of alloys except V with 10 per cent Sn and V with 10 per cent Al. The mechanical properties deduced from tensile strength tests carried out on alloy samples annealed 1 hour at 1050 deg. C in a vacuum show that, generally speaking, the addition elements lead to an improvement in these properties as compared to those of pure vanadium. After undergoing corrosion tests in a liquid sodium loop purified by a cold trap, the alloys become brittle at room temperature. Only the vanadium containing 20 per cent Ti keeps its plastic properties. These alloys are covered by a layer of vanadium carbide VC. After undergoing treatment in a liquid sodium loop purified by a hot trap, all the alloys keep their good mechanical characteristics. The surface layer with which they are covered is composed of two vanadium carbides VC and {sub {gamma}}VC, and a vanadium sub-oxide VO{sub 0.9}. (author) [French] Des etudes preliminaires ont ete faites sur une serie d'alliages a base de vanadium: V-0,5 pour cent Si, V-5 pour cent Ca, V-5 pour cent Mo, V-5 pour cent Nb, V-2 pour cent Zr, V-20 pour cent Ti, V-10 pour cent Al, V-10 pour cent Sn et V-10 pour cent Ti susceptibles d'etre utilises comme materiau de gainage pour les reacteurs rapides. La transformation par forgeage a 1000 deg. C environ et laminage entre 200 deg. C et la temperature ambiante est satisfaisante pour toutes les nuances d'alliage sauf le V-10 pour cent Sn et le V-10 pour cent Al. Les proprietes mecaniques deduites des essais de traction realises sur des eprouvettes d'alliages recuits 1 heure a
Movement and equipositioning of plasmids by ParA filament disassembly

DEFF Research Database (Denmark)

Ringgaard, Simon; van Zon, Jeroen; Howard, Martin

2009-01-01

, plasmids consistently migrate behind disassembling ParA cytoskeletal structures, suggesting that ParA filaments pull plasmids by depolymerization. The perpetual cycles of ParA assembly and disassembly result in continuous relocation of plasmids, which, on time averaging, results in equidistribution...
PAR-1 contributes to the innate immune response during viral infection

Science.gov (United States)

Antoniak, Silvio; Owens, A. Phillip; Baunacke, Martin; Williams, Julie C.; Lee, Rebecca D.; Weithäuser, Alice; Sheridan, Patricia A.; Malz, Ronny; Luyendyk, James P.; Esserman, Denise A.; Trejo, JoAnn; Kirchhofer, Daniel; Blaxall, Burns C.; Pawlinski, Rafal; Beck, Melinda A.; Rauch, Ursula; Mackman, Nigel

2013-01-01

Coagulation is a host defense system that limits the spread of pathogens. Coagulation proteases, such as thrombin, also activate cells by cleaving PARs. In this study, we analyzed the role of PAR-1 in coxsackievirus B3–induced (CVB3-induced) myocarditis and influenza A infection. CVB3-infected Par1–/– mice expressed reduced levels of IFN-β and CXCL10 during the early phase of infection compared with Par1+/+ mice that resulted in higher viral loads and cardiac injury at day 8 after infection. Inhibition of either tissue factor or thrombin in WT mice also significantly increased CVB3 levels in the heart and cardiac injury compared with controls. BM transplantation experiments demonstrated that PAR-1 in nonhematopoietic cells protected mice from CVB3 infection. Transgenic mice overexpressing PAR-1 in cardiomyocytes had reduced CVB3-induced myocarditis. We found that cooperative signaling between PAR-1 and TLR3 in mouse cardiac fibroblasts enhanced activation of p38 and induction of IFN-β and CXCL10 expression. Par1–/– mice also had decreased CXCL10 expression and increased viral levels in the lung after influenza A infection compared with Par1+/+ mice. Our results indicate that the tissue factor/thrombin/PAR-1 pathway enhances IFN-β expression and contributes to the innate immune response during single-stranded RNA viral infection. PMID:23391721
Reactivity coefficients by perturbation theory; Calcul des coefficients de re activite par la theorie des perturbations; Koehffitsienty reaktivnosti, opredelennye pri pomoshchi teorii vozmushchenij; Determinacion, de coeficientes de reactividad con ayuda de la teoria de las perturbaciones

Energy Technology Data Exchange (ETDEWEB)

Webster, J W [International Atomic Energy Agency, Vienna (Austria)

1962-03-15

lethargie, en procedant par analogie a partir de l'equation differentielle a un groupe relative au flux adjoint. b) Montre comment appliquer la forme a deux groupes de la theorie des perturbations au cas d'un reacteur surgenerateur a neutrons rapides, refroidi au mercure. Lors de l'essai preliminaire du reacteur, on a constate que la variation de reactivite accompagnant une variation de densite du mercure est telle que le coefficient net de la reactivite est negatif pour certaines regions et positif pour d'autres. Il est negatif pour les regions de poids statistique le plus eleve et ou une variation de puissance entrainerait le changement de densite le plus important. Le coefficient global de densite du mercure est donc negatif, et par consequent le coefficient cavitaire est positif, ce qui est dangereux. On peut facilement voir, en employant la forme a deux groupes, quelles modifications doivent etre apportees aux plans du reacteur etudie pour obtenir un coefficient cavitaire negatif. Au cours de recherches ulterieures, il s'est revele possible d'apporter certaines de ces modifications, et l'on est finalement parvenu a etablir des plans tels que le coefficient cavitaire du reacteur soit negatif. (author) [Spanish] Las formulas de la teoria de las perturbaciones pueden establecerse empleando uno de los procedimientos mas importantes de la heuristica matematica, que consiste en partir de una expresion sencilla para llegar por analogia a una expresion mas compleja. La presente memoria: (a) Formula la teoria de las perturbaciones como metodo para calcular los coeficientes de reactividad. Consiste principalmente en desarrollar la ecuacion diferencial del flujo adjunto como funcion continua de la posicion y del letargo, procediendo por analogia a partir de la ecuacion diferencial de un solo grupo para el flujo adjunto. (b) Presenta una aplicacion de la forma de dos grupos de la teoria de las perturba ciones a un reactor reproductor rapido, refrigerado por mercurio hirviente
Description of methods for making activation detectors for use in nuclear reactors; Description des procedes de fabrication des detecteurs d'activation utilises dans les reacteurs nucleaires

Energy Technology Data Exchange (ETDEWEB)

Barbalat, R; Le Coguie, R; Leger, P; Salon, L; Thierry, M [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1968-07-01

A brief description of methods currently used for making activation detectors, thin films and various deposits used in nuclear reactors. The thicknesses required vary from about a few tenths of a micron to a few tenths of a millimeter. Different techniques are used for fixing the large variety of elements: rolling, moulding, painting, electrolysis, vacuum deposition, thin films, wires, enamels, protective linings, etc. (authors) [French] Expose succinct des procedes actuellement mis en oeuvre pour la realisation des detecteurs d'activation, feuilles minces et depots divers utilises dans les reacteurs nucleaires. La gamme des epaisseurs necessaires s'etendant approximativement des dixiemes de micrometre aux dixiemes de millimetre. La diversite des elements a fixer justifiant les techniques differentes selon les cas: laminage, moulage, peinture, electrolyse, depot sous vide, couches minces, fils, emaux, revetements protecteurs, etc. (auteurs)
Industrial Ultrasonic Inspection of Stainless-Steel Claddings for the EL4 Reactor; Controle Industriel par Ultrasons des Gaines en Acier Inoxydable du Reacteur EL4; Promyshlennyj kontrol' obolochechnykh trub iz nerzhaveyushchej stali reaktora dlya EL4 s pomoshch'yu ul'trazvukovogo metoda; Metodos Ultrasonicos para Control Industrial de las Vainas de Acero Inoxidable del Reactor EL4

Energy Technology Data Exchange (ETDEWEB)

Prot, A. C.; Foulquoer, H. E.; Peyrot, J. P. [Centre d' Etudes Nucleaires de Saclay (France)

1965-09-15

essentiel de rentabilite du reacteur. Il s'avere que le choix de la methode a utiliser et a mettre au point est delicat; le memoire en donne les elements essentiels. Ce choix etant fait, apres mise au point en laboratoire, deux nouveaux problemes se posent: - la transposition dans le domaine industriel; - la necessite de tenir compte de la qualite permise, a un instant determine, par les procedes de fabrication, en relation avec les normes de reception definies de maniere plus ou moins arbitraire. Ceci se traduit en fait par la necessite d'une etude statistique sur des lots de tubes de diverses provenances, et leur classement par rapport a des seuils plus ou moins severes. On verra que le nombre de tubes a controler est tres superieur a celui prevu initialement. Cela conduit a l'etude d'une machine de controle automatique, capable de satisfaire a la fois les exigences de cadence et celles propres au type de controle choisi: ces dernieres sont generalement d'ordre mecanique et necessitent une construction particulierement soignee. L'ensemble de ces considerations a conduit a concevoir une machine dont la cadence peut des maintenant couvrir sans difficulte les besoins d'une chaihe de fabrication d'elements combustibles. Les possibilites de cette machine sont etroitement liees aux caracteristiques du materiel de controle choisi, en particulier aux performances de l'electronique des appareils de controle par ultrasons et a celles des traducteurs utilises. Il resulte d'ailleurs de cette etude que le materiel standard ne repond que tres imparfaitement au probleme et que l'on doit envisager des maintenant un appareillage particulier pour ce type de controle. (author) [Spanish] Las mayores exigencias a que se someten los reactores obligan a utilizar materiales elaborados y controlados con sumo cuidado. Un aspecto de tal control se refiere a la calidad de las vainas empleadas, cuyas propiedades mecanicas ejercen una influencia decisiva sobre la rentabilidad del reactor. La eleccion

Peptide-Based Optical uPAR Imaging for Surgery

DEFF Research Database (Denmark)

Juhl, Karina; Christensen, Anders; Persson, Morten

2016-01-01

Near infrared intra-operative optical imaging is an emerging technique with clear implications for improved cancer surgery by enabling a more distinct delineation of the tumor margins during resection. This modality has the potential to increase the number of patients having a curative radical...... tumor resection. In the present study, a new uPAR-targeted fluorescent probe was developed and the in vivo applicability was evaluated in a human xenograft mouse model. Most human carcinomas express high level of uPAR in the tumor-stromal interface of invasive lesions and uPAR is therefore considered...... an ideal target for intra-operative imaging. Conjugation of the flourophor indocyanine green (ICG) to the uPAR agonist (AE105) provides an optical imaging ligand with sufficiently high receptor affinity to allow for a specific receptor targeting in vivo. For in vivo testing, human glioblastoma xenograft...
Some fundamental aspects of boiling in nuclear reactors; Quelques aspects fondamentaux de l'ebullition dans les reacteurs nucleaires

Energy Technology Data Exchange (ETDEWEB)

Mondin, H; Lavigne, P; Semeria, R [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1964-07-01

oscillation, the conditions of burnout are compared with those obtained under steady conditions. The burn-out flux following uniform 'stopped' heating has been studied in a channel containing still water. The flux shows a maximum as a function of unsaturation. The influence of the geometry and the nature of the metal was investigated. 4 - Output Oscillations: Using a low pressure (8 atm) loop, the influence of various parameters on the periods of output oscillations in a boiling channel on the thresholds at which they appear, was studied. Some new aspects of this complex phenomena were observed and are reported. (authors) [French] On indique les principaux resultats obtenus a Grenoble depuis quatre ans dans le domaine des mecanismes de l'ebullition et des phenomenes connexes dans les reacteurs nucleaires. 1 - OBSERVATION DE L'EBULLITION: Par photographie et cinematographie ultrarapide (8000 images par seconde maximum) on a observe l'ebullition en vase ou en canal jusqu'a 140 kg/cm{sup 2}. On a denombre les populations de germes (sites) generateurs de bulles et obtenu une correlation donnant leur nombre par unite de surface en fonction du flux thermique et de la pression. Le diametre des bulles se detachant de la paroi a ete etudie jusqu'a 140 kg/cm{sup 2}. On a mis en evidence trois types de bulles: - Les bulles en equilibre dont le diametre suit la formule de Fritz et Ende, - Les bulles d'ebullition dont le diametre diminue rapidement avec la pression (1/100 mm a 140 kg/cm{sup 2}), - Les coalescences apparaissant en liquide sature au-dessus de 15 W/cm{sup 2} et dont la proportion est independante de la pression. Par visualisation en strioscopie on observe les mouvements du film thermique associes a l'amorcage des germes, au depart et a la condensation des bulles; les mecanismes responsables de l'excellent transfert de chaleur ont pu ainsi etre precises. 2 - PERTES DE PRESSION EN ECOULEMENT DIPHASE: On a etabli un modele de variation continue du taux de vide dans un canal
Heats of formation of chlorine fluorides; Chaleurs de formation des fluorures de chlore

Energy Technology Data Exchange (ETDEWEB)

Barberi, P; Caton, J; Guillin, J; Hartmanshenn, O [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1969-07-01

The enthalpies of formation of the chlorine fluorides ClF, ClF{sub 3} and ClF{sub 5} have been determined by combustion calorimetry in hydrogen. They have the respective values, 13.9, 37.2 and 57.2 Kcals.mole. Two bomb calorimeters with differing principles (high-frequency spark bomb and double compartment bomb) have been developed for this purpose. (authors) [French] Les enthalpies de formation des fluorures de chlore ClF, ClF{sub 3} et ClF{sub 5} ont ete determinees par calorimetrie de combustion dans l'hydrogene. Elles sont respectivement de 13.9, 37.2 et 57.2 Kcal.mole. Deux bombes calorimetriques de principes differents (bombe a etincelle haute frequence et bombe a double compartiment) ont ete mises au point a cette occasion. (auteurs)
Dynamic Filament Formation by a Divergent Bacterial Actin-Like ParM Protein.

Directory of Open Access Journals (Sweden)

Anthony J Brzoska

Full Text Available Actin-like proteins (Alps are a diverse family of proteins whose genes are abundant in the chromosomes and mobile genetic elements of many bacteria. The low-copy-number staphylococcal multiresistance plasmid pSK41 encodes ParM, an Alp involved in efficient plasmid partitioning. pSK41 ParM has previously been shown to form filaments in vitro that are structurally dissimilar to those formed by other bacterial Alps. The mechanistic implications of these differences are not known. In order to gain insights into the properties and behavior of the pSK41 ParM Alp in vivo, we reconstituted the parMRC system in the ectopic rod-shaped host, E. coli, which is larger and more genetically amenable than the native host, Staphylococcus aureus. Fluorescence microscopy showed a functional fusion protein, ParM-YFP, formed straight filaments in vivo when expressed in isolation. Strikingly, however, in the presence of ParR and parC, ParM-YFP adopted a dramatically different structure, instead forming axial curved filaments. Time-lapse imaging and selective photobleaching experiments revealed that, in the presence of all components of the parMRC system, ParM-YFP filaments were dynamic in nature. Finally, molecular dissection of the parMRC operon revealed that all components of the system are essential for the generation of dynamic filaments.
An instrument for measuring doubling time; Un appareillage de mesure de temps de doublement

Energy Technology Data Exchange (ETDEWEB)

Ailloud, J; Chandanson, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1956-07-01

The instrument described here allows the direct and almost immediate measurement, with a precision of the order of 1 per cent, of the time taken by a reactor to double its power. The method of measurement consists of noting the instants when the power of the reactor passes the levels P{sub 1} and P{sub 2} such that P{sub 2} = 2 P{sub 1}, and of measuring the time lapse between these two instants. The instrument picks out, in the course of one rise in power, several levels, P{sub 1}, P{sub 2}, P{sub 3}... etc, chosen in such a manner as to give several successive measurements of the doubling time. It is also capable of making these same measurements when the reactor is working below the critical level. (author) [French] L'appareil decrit ici permet la mesure directe et quasi immediate du temps de doublement de la puissance d'un reacteur avec une precision de l'ordre de 1 pour cent. La methode de mesure consiste a reperer les instants de passage de la puissance du reacteur par des niveaux P{sub 1} et P{sub 2} tels que P{sub 2} = 2 P{sub 1}, et a mesurer le temps ecoule entre ces deux instants. L'appareil repere, au cours d'une meme montee en puissance, plusieurs niveaux, P{sub 1}, P{sub 2}, P{sub 3}... etc, choisis de maniere a donner plusieurs mesures successives du temps de doublement. Il est egalement utilisable pour effectuer ces memes mesures lorsque le reacteur est en regime sous-critique. (auteur)
First (18)F-labeled ligand for PET imaging of uPAR

DEFF Research Database (Denmark)

Persson, Morten; Liu, Hongguang; Madsen, Jacob

2013-01-01

Urokinase-type plasminogen activator receptor (uPAR) is overexpressed in human prostate cancer and uPAR has been found to be associated with metastatic disease and poor prognosis. AE105 is a small linear peptide with high binding affinity to uPAR. We synthesized an N-terminal NOTA......-conjugated version (NOTA-AE105) for development of the first (18)F-labeled uPAR positron-emission-tomography PET ligand using the Al(18)F radiolabeling method. In this study, the potential of (18)F-AlF-NOTA-AE105 to specifically target uPAR-positive prostate tumors was investigated....
Narrative Identities and the Plebiscite in Pará: An Analysis of the Front Pages for O Liberal and Diário do Pará

Directory of Open Access Journals (Sweden)

Alda Cristina Silva da Costa

2017-05-01

Full Text Available On December 11, 2011, a plebiscite was held in Pará proposing to create two separatist states, Carajás and Tapajós, out of the state of Pará. The public voted against both projects. This article analyzes the narrative identities found on the front pages of O Liberal and Diário do Pará newspapers about the plebiscite in Pará. Depth Hermeneutics (DH, as proposed by Thompson (2011, was used as the methodological reference. DH emphasizes the object of analysis as a meaningful symbolic construction requiring interpretation. Narrative analysis, as proposed by Motta (2007, was the main research technique used to highlight the movement of construction of journalistic (discursive characters. The narrative identities built by the two newspapers showed that both were against the creation of the new states, but for very different reasons. The flag of Pará was the main object used to induce the idea of unity. Em 11 de dezembro de 2011, o plebiscito no Pará propôs a criação dos estados de Carajás e de Tapajós a partir da divisão do estado do Pará. O resultado da consulta pública foi negativo aos dois projetos. O artigo analisa as identidades narrativas constituídas pelas primeiras páginas dos jornais O Liberal e Diário do Pará sobre o plebiscito no Pará. Utilizou-se como referencial metodológico a Hermenêutica em Profundidade (HP, proposta por Thompson (2011. A HP evidencia o fato de que o objeto de análise é uma construção simbólica significativa, que exige uma interpretação. Como principal técnica de pesquisa, a análise narrativa, proposta por Motta (2007, com ênfase no movimento de construção de personagens jornalísticas (discursivas. As identidades narrativas construídas pelos dois jornais indicaram que ambos eram contrários à criação dos novos estados, porém por motivos divergentes. A bandeira do Pará foi o principal elemento utilizado para evocar a ideia de unidade. En 11 de diciembre de 2011, el plebiscito en
Limnological database for Par Pond: 1959 to 1980

International Nuclear Information System (INIS)

Tilly, L.J.

1981-03-01

A limnological database for Par Pond, a cooling reservoir for hot reactor effluent water at the Savannah River Plant, is described. The data are derived from a combination of research and monitoring efforts on Par Pond since 1959. The approximately 24,000-byte database provides water quality, primary productivity, and flow data from a number of different stations, depths, and times during the 22-year history of the Par Pond impoundment. The data have been organized to permit an interpretation of the effects of twenty years of cooling system operations on the structure and function of an aquatic ecosystem
Spatial flux instabilities, and their control in the graphite gas power reactors; Les instabilites spatiales du flux et leur controle dans les reacteurs de puissance graphite-gaz

Energy Technology Data Exchange (ETDEWEB)

Cailly, J L [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

Radial-azimuthal and axial spatial flux instabilities in graphite-gas reactors are studied by means of an analytical approach. Results are checked with those which are given by two dimensional (r, z and r, {theta}) kinetic models programmed for an IBM 7094 computer. At least, conclusions on the control of instabilities obtained from these models are reported. (author) [French] Les instabilites spatiales du flux dans les reacteurs graphite-gaz, radiales et azimutales d'une part, axiales d'autre part, sont etudiees au moyen d'une formulation analytique. Les resultats sont confrontes avec ceux que fournissent des modeles cinetiques a deux dimensions (r, z et r, {theta}) programmes sur IBM 7094. On donne enfin les conclusions relatives au controle de ces instabilites que ces modeles ont permis de degager. (auteur)
Use of 14 MeV neutrons in activation analysis. Experiments carried out at the Grenoble nuclear research Centre (1963); Utilisation de neutrons de 14 MeV en analyse par activation. Experience realisee au Centre d'etudes nucleaires de Grenoble (1963)

Energy Technology Data Exchange (ETDEWEB)

Auboin, G; Guazzoni, P; Laverlochere, J [Commisariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1963-07-01

The use of 14 MeV neutron irradiation makes it possible to extend the field of application of activation analysis to elements which cannot be activated in nuclear reactors (oxygen, boron, for example) or else to consider the possibility of 'portable' measurement units for routine analyses. With this aim, tests have been carried out for studying the sensitivity and interferences in the case of the dosing of oxygen in eleven different matrices using 150 and 300 kV SAMES accelerators producing 14 MeV neutrons by the reaction {sup 3}H (d, n) {sup 4}He. The sensitivity of the dosage methods for six writer elements has also been studied. The results obtained show that, for a neutron flux of 10{sup 10} n/4{pi}, the sensitivities vary from 100 {mu}g and 1 mg for oxygen in nine matrices (Be, Ta, Nb, Ti, Zr, Fe, Al, Sb, Si) and that it is possible to dose the six elements F, B, Y, Si, N, Al with sensitivities of between 1 an 1000 micrograms. (authors) [French] L'irradiation au moyen de neutrons de 14 MeV permet d'etendre le domaine d'application de l'analyse par activation a des elements non activables en reacteur nucleaire (oxygene, bore, par exemple) ou encore d'envisager des unites de dosage ''portables'' pour des analyses de routine. Dans ce but, des essais ont ete effectues pour etudier les sensibilites et les interferences dans le cas du dosage de l'oxygene dans onze matrices differentes, au moyen d'accelerateurs SAMES 150 et 300 kV. produisant les neutrons de 14 MeV par la reaction {sup 3}H (d, n) {sup 4}He. Des sensibilites de dosage ont egalement ete etudiees pour six autres elements. Les resultats obtenus montrent que, pour un flux de neutrons de 10{sup 10} n /4{pi}, les sensibilites varient entre 100 {mu}g et 1 mg, pour l'oxygene dans neuf matrices (Be, Ta, Nb, Ti, Zr, Fe, Al, Sb, Si) et qu'il est possible de doser les six elements F, B, Y, Si, N, Al avec des sensibilites se situant entre 1 et 1000 microgrammes. (auteurs)
Soluble urokinase plasminogen activator receptor (suPAR) in acute care

DEFF Research Database (Denmark)

Rasmussen, Line Jee Hartmann; Ladelund, Steen; Haupt, Thomas Huneck

2016-01-01

for age, sex, Charlson score and C reactive protein. Area under the curve for receiver operating characteristics curve analysis of suPAR for 30-day mortality was 0.84 (95% CI 0.81 to 0.86). Furthermore, in the entire cohort, women had slightly higher suPAR compared with men, and suPAR was associated...
A study of the fluorescence of the rare gases excited by nuclear particles. Use of the principle for the detection of nuclear radiation by scintillation; Etude de la fluorescence des gaz rares excites par des particules nucleaires. Utilisation pour la detection des rayonnements nucleaires par scintillation

Energy Technology Data Exchange (ETDEWEB)

Koch, L [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1959-12-15

composantes, l'une tres breve due a la desexcitation directe du gaz rare, l'autre relativement plus lente, due au transfert d'energie sur les impuretes. La mesure des durees de vie des etats excites a confirme l'hypothese precedente, la partie breve de l'impulsion est extremement courte: inferieure a 2,25.10{sup -9} s dans le cas du xenon, la partie plus lente a une duree qui depend etroitement de la concentration d'azote, l'azote etant l'impurete dont le role est preponderant dans tous les cas. L'etude des gaz rares soumis a un champ electrique a permis de montrer que la quantite de lumiere produite par une particule {alpha} peut etre multipliee (par 60 dans un champ de 600 V/cm par exemple) ce qui correspond a un rendement de luminescence superieur a celui de INa TI. Dans la deuxieme partie on a etudie les caracteristiques des gaz rares comme scintillateurs, la plus importante est l'absence de saturation de la fluorescence lorsque la densite d'excitation transmise au gaz devient tres grande. Ceci joint au temps de scintillation tres court a permis d'etudier un certain nombre d'applications a la physique nucleaire (mesure d'energie des particules lourdes, etude cinetique des reacteurs nucleaires, spectroscopie des neutrons...). (auteur)
Fast neutron flux in heavy water reactors; Flux de neutrons rapides dans les piles a eau lourde

Energy Technology Data Exchange (ETDEWEB)

Brisbois, J; Katz, S [Commissariat a l' Energie Atomique, Centre d' Etudes Nucleaires de Fontenay-aux-Roses, 92 (France)

1966-07-01

The possibility of calculating the fast neutron flux in a natural uranium-heavy water lattice by superposition of the individual contributions of the different fuel elements was verified using a one-dimension Monte-Carlo code. The results obtained are in good agreement with experimental measurements done in the core and reflector of the reactor AQUILON. (author) [French] La possibilite de calculer le flux de neutrons rapides dans un reseau d'uranium naturel a eau lourde par superposition des apports des divers barreaux, a ete verifiee en utilisant un code Monte-Carlo monodimensionel. Les resultats obtenus concordent avec des mesures experimentales effectuees dans le coeur et reacteur de la pile Aquilon. (auteurs)
The study of some thiazinic and indaminic dye syntheses induced by ionising radiation; Etude de quelques syntheses de colorants thianziniques et indaminiques amorcees par les rayonnements ionisants

Energy Technology Data Exchange (ETDEWEB)

Balestic, S [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1961-03-15

With a view to finding some radiochemical reactions applicable on an industrial scale for evaluating the radioactive waste from nuclear reactors, a systematic study was made of the radiochemical synthesis of thiazinic dyes such as methylene blue and Lauths' violet, on which the first tests were carried out in 1954. The first part of the study concerned the identification and the dosage, during radiolysis, of dyes by means of their absorption spectra after separation from the reaction medium by adsorption chromatography or ion-exchange; other radiolysis products such as ammonium chloride and hydrogen peroxide were also identified. During a later stage by systematically varying the physico-chemical parameters it was possible to determine the most favourable conditions for radio-synthesis; the maximum radiochemical yields obtained had the following values: G (Lauths' violet) 1,65; G (Methylene blue) = 1,75. Furthermore, the study of the influence of variously substituted aminated products on the radiochemical yield showed the possibility of synthesising Bindsehedlers green and Wursters blue by radiochemical methods. Finally the discovery of a fundamental intermediate product, Wursters red, together with the kinetic study of the chemical synthesis of methylene blue made it possible to determine the main stages of the reaction mechanism and to decide which of these stages could be attributed to ionising radiations in the case of the radiochemical synthesis. (author) [French] Dans le but de trouver des reactions radiochimiques susceptibles d'une application industrielle pour valoriser les dechets radioactifs provenant des reacteurs nucleaires, il a ete entrepris une etude systematique de la synthese radiochimique des colorants thiazimiques tels que le Bleu de Methylene et le Violet de Lauth dont les premiers essais ont ete effectues par Loiseleur en 1954. La premiere partie de l'etude a porte sur l'identification et le dosage des colorants formes au cours de la radiolyse
Intact and cleaved uPAR forms: diagnostic and prognostic value in cancer

DEFF Research Database (Denmark)

Rasch, M.G.; Lund, I.K.; Hoyer-Hansen, G.

2008-01-01

identified in tissue and body fluids. It is well-established, that the total amount of all uPAR forms is a strong prognostic marker in different types of cancer. Using immunoassays, measuring the individual uPAR forms, has revealed that the cleaved uPAR forms are even stronger prognostic markers and have...... diagnostic utility. This review will focus on the mechanism of uPAR cleavage and the functional consequences, as well as the clinical applicability of cleaved uPAR forms Udgivelsesdato: 2008...
The fuel element of the first charge for EL 4; presentation, main problems arising in the research, production problems; L'element combustible du 1. jeu de EL 4; presentation, problemes essentiels poses par l'etude, problemes de fabrication

Energy Technology Data Exchange (ETDEWEB)

Ringot, C; Bailly, H; Bujas, R [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

The fuel element making up the first charge for EL-4 is made of slightly enriched uranium oxide canned in stainless steel. This fuel element makes it possible to operate the reactor in the safest conditions awaiting the development of the fuel which will be finally adopted; this will have a low absorption can: beryllium, or a zirconium copper alloy. The 500 mm assembly is made up of 19 small rods placed on 3 rings, inside a graphite jacket. The solution adopted was a solution using completely independent small rods. This report deals with possible problems resulting from their study and production. (authors) [French] L'element combustible du 1er jeu EL-4 est un element combustible a oxyde d'uranium legerement enrichi gaine d'acier inoxydable. C'est un element combustible permettant de faire fonctionner le reacteur EL 4 dans des conditions aussi sures que possible avant de mettre au point le combustible definitif qui sera a gaine peu absorbante: beryllium, ou alliage zirconium-cuivre. L'assemblage de longueur 500 mm est constitue de 19 crayons places sur 3 couronnes, a l'interieur d'une chemise de graphite. La solution adoptee a ete une solution a crayons independants les uns des autres. Ce rapport traite des problemes eventuels poses par leur etude et leur fabrication. (auteurs)
A Bipolar Spindle of Antiparallel ParM Filaments Drives Bacterial Plasmid Segregation

DEFF Research Database (Denmark)

Gayathri, P; Fujii, T; Møller-Jensen, Jakob

2012-01-01

the spindle between ParRC complexes on sister plasmids. Using a combination of structural work and total internal reflection fluorescence microscopy, we show that ParRC bound and could accelerate growth at only one end of polar ParM filaments, mechanistically resembling eukaryotic formins. The architecture...... of ParM filaments enabled two ParRC-bound filaments to associate in an antiparallel orientation, forming a bipolar spindle. The spindle elongated as a bundle of at least two antiparallel filaments, thereby pushing two plasmid clusters toward the poles....
A study of switch circuits for use as safety devices in nuclear reactors; Etude de circuits de commutation destines a la securite des reacteurs nucleaires

Energy Technology Data Exchange (ETDEWEB)

Hantcherian, V [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1960-12-15

The author reviews briefly a few basic assemblies using electromagnetic relays for safety circuits in nuclear reactors; he then studies the use of static relays with a shorter time of response, based on impedance changes in a self-inductance consisting of a coil with a magnetic core having a rectangular hysteresis cycle. The author examines in particular the way in which it functions and the method of determining the parameters. (author) [French] L'auteur apres avoir examine sommairement en revue quelques montages de base des circuits de securite des reacteurs nucleaires utilisant des relais electromecaniques, etudie l'emploi des relais statiques a plus grande vitesse de reponse bases sur la variation d'impedance que presente une self-inductance realisee a l'aide d'une bobine enroulee autour d'un noyau magnetique a cycle d'hysteresis rectangulaire. En particulier, il en examine le mode de fonctionnement et la determination des parametres. (auteur)
PAR-2 expression in the gingival crevicular fluid reflects chronic periodontitis severity

Directory of Open Access Journals (Sweden)

Henrique FUKUSHIMA

Full Text Available Abstract Recent studies investigating protease-activated receptor type 2 (PAR-2 suggest an association between the receptor and periodontal inflammation. It is known that gingipain, a bacterial protease secreted by the important periodontopathogen Porphyromonas gingivalis can activate PAR-2. Previous studies by our group found that PAR-2 is overexpressed in the gingival crevicular fluid (GCF of patients with moderate chronic periodontitis (MP. The present study aimed at evaluating whether PAR-2 expression is associated with chronic periodontitis severity. GCF samples and clinical parameters, including plaque and bleeding on probing indices, probing pocket depth and clinical attachment level, were collected from the control group (n = 19 at baseline, and from MP patients (n = 19 and severe chronic periodontitis (SP (n = 19 patients before and 6 weeks after periodontal non-surgical treatment. PAR-2 and gingipain messenger RNA (mRNA in the GCF of 4 periodontal sites per patient were evaluated by Reverse Transcription Polymerase Chain Reaction (RT-qPCR. PAR-2 and gingipain expressions were greater in periodontitis patients than in control group patients. In addition, the SP group presented increased PAR-2 and gingipain mRNA levels, compared with the MP group. Furthermore, periodontal treatment significantly reduced (p <0.05 PAR-2 expression in patients with periodontitis. In conclusion, PAR-2 is associated with chronic periodontitis severity and with gingipain levels in the periodontal pocket, thus suggesting that PAR-2 expression in the GCF reflects the severity of destruction during periodontal infection.
Structures of actin-like ParM filaments show architecture of plasmid-segregating spindles.

Science.gov (United States)

Bharat, Tanmay A M; Murshudov, Garib N; Sachse, Carsten; Löwe, Jan

2015-07-02

Active segregation of Escherichia coli low-copy-number plasmid R1 involves formation of a bipolar spindle made of left-handed double-helical actin-like ParM filaments. ParR links the filaments with centromeric parC plasmid DNA, while facilitating the addition of subunits to ParM filaments. Growing ParMRC spindles push sister plasmids to the cell poles. Here, using modern electron cryomicroscopy methods, we investigate the structures and arrangements of ParM filaments in vitro and in cells, revealing at near-atomic resolution how subunits and filaments come together to produce the simplest known mitotic machinery. To understand the mechanism of dynamic instability, we determine structures of ParM filaments in different nucleotide states. The structure of filaments bound to the ATP analogue AMPPNP is determined at 4.3 Å resolution and refined. The ParM filament structure shows strong longitudinal interfaces and weaker lateral interactions. Also using electron cryomicroscopy, we reconstruct ParM doublets forming antiparallel spindles. Finally, with whole-cell electron cryotomography, we show that doublets are abundant in bacterial cells containing low-copy-number plasmids with the ParMRC locus, leading to an asynchronous model of R1 plasmid segregation.

Par and IR reflectance, transmittance, and absorptance of four crop canopies

International Nuclear Information System (INIS)

Wanjura, D.F.; Hatfield, J.L.

1986-01-01

Reflectance, transmittance and absorptance of electromagnetic radiation by cotton, soybeans, grain sorghum, and sunflower was measured at three growth stages in two wavebands (PAR: 0.4 to 0.7 pun and IR: 0.7 to 1.1 yim). As leaf area increased in each crop there were increases in IR reflectance and PAR absorptance and decreases in PAR reflectance and both PAR and IR transmittance. IR radiation was concentrated at the soil surface between rows by reflectance from the sides of canopies when crop cover was less than 80%. Across all crops one parameter, leaf overlap index, explained 81 and 71% of the PAR reflectance and another, crop cover, explained 86 and 94% of IR reflectance from rows and interrows, respectively. Attenuation of PAR radiation through the canopies of cotton and sunflower was similar (K = 0.62 and 0.67) but different from that of soybeans and grain sorghum (K = 0.46 and 0.43) which were the same
Épidémiologie de l'intoxication par envenimation chez les enfants ...

African Journals Online (AJOL)

Introduction: L'intoxication par envenimation est l'ensemble des manifestations locales et générales induites par la pénétration dans l'organisme d'une substance toxique produite par un animal venimeux. Le but de notre travail était d'étudier les signes cliniques des intoxications par envenimation chez les enfants de 0 à 15 ...
The uranium dioxide-uranium system at high temperature; Le systeme uranium-dioxyde d'uranium a haute temperature

Energy Technology Data Exchange (ETDEWEB)

Guinet, Ph.; Vaugoyeau, H.; Blum, P. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1966-07-01

The liquidus curve has been determined by a saturation method in which the thermal gradient was cancelled upon cooling, and the solidus curve by analyzing the deposits in equilibrium with the liquid at each temperature. The diagram, of a displaced eutectic type, presents a liquid immiscibility domain between 47 and 59 mol per cent of dioxide and a substoichiometry range UO{sub 2x}, the minimum O/U ratio being 1,6 at 3470 {+-} 30 C. The monotectic composition was found by chemical analysis to be 59 mol per cent of dioxide and the reaction temperature 2470 {+-} 30 C. (author) [French] La courbe liquidus a ete determinee par une methode de saturation en annulant le gradient thermique au cours du refroidissement, la courbe solidus par analyse des depots en equilibre avec le liquide a chaque temperature. Le diagramme du type a eutectique deporte comporte un domaine d'immiscibilite liquide entre 47 et 59 moles pour cent de dioxyde, ainsi qu'un domaine d'existence du compose sous stoechiometrique UO{sub 2x}, le rapport O/U minimum etant egal a 1,6 a 2470 {+-} 30 C. La composition du monotectique, obtenue par analyse chimique, est de 59 moles pour cent de dioxyde et la temperature de la reaction a ete trouvee egale a 2470 {+-} 30 C. (auteur)
PARs for combustible gas control in advanced light water reactors

International Nuclear Information System (INIS)

Hosler, J.; Sliter, G.

1997-01-01

This paper discusses the progress being made in the United States to introduce passive autocatalytic recombiner (PAR) technology as a cost-effective alternative to electric recombiners for controlling combustible gas produced in postulated accidents in both future Advanced Light Water Reactors (ALWRs) and certain U. S. operating nuclear plants. PARs catalytically recombine hydrogen and oxygen, gradually producing heat and water vapor. They have no moving parts and are self-starting and self-feeding, even under relatively cold and wet containment conditions. Buoyancy of the hot gases they create sets up natural convective flow that promotes mixing of combustible gases in a containment. In a non-inerted ALWR containment, two approaches each employing a combination of PARs and igniters are being considered to control hydrogen in design basis and severe accidents. In pre-inerted ALWRs, PARs alone control radiolytic oxygen produced in either accident type. The paper also discusses regulatory feedback regarding these combustible gas control approaches and describes a test program being conducted by the Electric Power Research Institute (EPRI) and Electricite de France (EdF) to supplement the existing PAR test database with performance data under conditions of interest to U.S. plants. Preliminary findings from the EPRI/EdF PAR model test program are included. Successful completion of this test program and confirmatory tests being sponsored by the U. S. NRC are expected to pave the way for use of PARs in ALWRs and operating plants. (author)
Brulure par Plaque de Bistouri Electrique: a Propos de Quatre Cas

Science.gov (United States)

Khales, A.; Achbouk, A.; Belmir, R.; Cherkab, L.; Ennouhi, M.A.; Ababou, K.; Ihrai, H.

2010-01-01

Summary La brûlure par plaque de bistouri électrique est un accident rare mais grave par la profondeur de la lésion et par sa localisation, surtout quand qu’elle survient dans un contexte chirurgical dont le vécu reste difficile de la part du malade et du chirurgien. Cette brûlure bien que imprévisible reste grave par la profondeur et la localisation de la brûlure et par sa survenue dans un contexte opératoire, chez des patients malades. La prise en charge de la brûlure doit se faire en milieu spécialisé. La prévention reste le seul moyen d’éviter ce type d’accident. PMID:21991216
Elusloom lennukiga puhkusele / Inge Parring

Index Scriptorium Estoniae

Parring, Inge

2003-01-01

Ilmunud ka: Delovõje Vedomosti 1. okt. lk. 13. Air Cargo Estonia/ACE Logisticsi müügijuht Inge Parring tutvustab elusloomade transpordivõimalusi. Vt. samas: Loomade transportimiseks vajalikud dokumendid
suPAR

DEFF Research Database (Denmark)

Eugen-Olsen, Jesper; Giamarellos-Bourboulis, Evangelos J

2015-01-01

Investigation of biomarkers that can promptly predict unfavourable outcome of critically illness is an emerging necessity taking into consideration the need for early intervention, the shortage of available beds in intensive care units and the considerable cost of hospitalisation. The most...... promising biomarker is soluble urokinase-type plasminogen activator receptor (suPAR). Three studies in large populations of critically ill patients and patients admitted to the emergency department have shown that concentrations >12ng/mL can safely predict unfavourable outcome. This review presents...
Urine suPAR levels compared with plasma suPAR levels as predictors of post-consultation mortality risk among individuals assumed to be TB-negative: a prospective cohort study

DEFF Research Database (Denmark)

Rabna, Paulo; Andersen, Andreas; Wejse, Christian

2010-01-01

-suPAR was measured using a commercial ELISA (suPARnostic®). We found that U-suPAR carried significant prognostic information on mortality for HIV-infected subjects with an area under the ROC curve of 0.75. For HIV-negative individuals, little or no prognostic effect was observed. However, in both HIV positives...... and negatives, the predictive effect of U-suPAR was found to be inferior to that of P-suPAR....
Brésil : La contamination par le mercure en Amazonie | CRDI ...

International Development Research Centre (IDRC) Digital Library (Canada)

11 janv. 2011 ... En tentant de déceler la source de la contamination de l'Amazone par le ... par Jean-Rémy Davy Guimaraes de l'Université fédérale de Rio de Janeiro ... ces mattes est circonscrite par la conservation et la restauration en rive.
Operating Experience with the BR-5 Reactor; Experience acquise aupres du reacteur BR-5; Opyt ehkspluatatsii reaktora BR-5; Experiencia practica con el reactor BR-5

Energy Technology Data Exchange (ETDEWEB)

Lejpunskij, A. I.; Kazachkovskij, O. D.; Pinkhasik, M. S.; Aristarkhov, N. N.; Karpov, A. V.; Larin, E. P.; Efimov, I. A.

1963-10-15

The paper discusses the carrying-out of repair and maintenance work on the radioactive liquid-metal circuit of the BR-5 fast neutron reactor. Attention is also given to problems of reactor operation after achievement of the planned 2% fuel burn-up with some disturbance of leak-tightness in individual fuel elements. An account is given of experience in discharging the active section, examining the condition and leak-tightness of the fuel elements, and decontaminating the equipment and piping of the first radioactive circuit after reaching 5% fuel burn-up. (author) [French] Dans ce memoire les auteurs decrivent l'execution des reparations et des travaux d'entretien dans le circuit radioactif liquide-metal du reacteur a neutrons rapides BR-5. Ils etudient egalement les problemes lies au fonctionnement du reacteur au taux de combustion de 2% prevu avec quelques defauts d'etancheite dans des elements combustibles particuliers. Ils decrivent le dechargementen zone active et examinent les conditions d'etancheite des elements combustibles. Ainsi que la decontamination de l'appareillage et des tuyauteries du premier circuit radioactif apres avoir atteint un taux de combustion de 5%. (author) [Spanish] En la memoria se examinan los problemas planteados por el mantenimiento del circuito radiactivo de metal liquido del reactor de neutrones rapidos BR-5. Se tratan cuestiones relacionadas con la explotacion del reactor una vez alcanzado el grado de combustion de 2%, previsto en el proyecto y luego de producirse ciertas alteraciones de la densidad de determinados elementos combustibles. Se describen la experiencia adquirida durante la descarga del cuerpo del reactor, las investigaciones del estado general y de la hermeticidad de los elementos combustibles y las operaciones de descontaminacion de la instalacion y de las tuberias del circuito radiactivo primario despues de alcanzado un grado de combustion de 5%. (author) [Russian] V doklade rassmatrivayutsya voprosy proizvodstva
Electron microscope study of vacancy clusters produced by quenching in magnesium; Etude par microscopie electronique des amas de lacunes crees par trempe dans le magnesium

Energy Technology Data Exchange (ETDEWEB)

Levy, V; Espinasse, J; Mairy, C; Hillairet, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1969-07-01

Vacancy clustering in quenched magnesium has been studied by transmission electron microscopy. The nature of the vacancy loops observed, seems to depend essentially on the impurity content of the metal; this effect can be attributed to a variation of the stacking fault energy of magnesium due to impurities. (authors) [French] On a etudie par microscopie electronique en transmission les defauts crees par trempe dans le magnesium. Un effet considerable des impuretes du metal sur la nature des boucles obtenues par condensation de lacunes a ete mis en evidence; cet effet semble s'expliquer de facon satisfaisante par un abaissement de l'energie de faute d'empilement du magnesium du aux impuretes. (auteur)
ParABS Systems of the Four Replicons of Burkholderia cenocepacia: New Chromosome Centromeres Confer Partition Specificity†

Science.gov (United States)

Dubarry, Nelly; Pasta, Franck; Lane, David

2006-01-01

Most bacterial chromosomes carry an analogue of the parABS systems that govern plasmid partition, but their role in chromosome partition is ambiguous. parABS systems might be particularly important for orderly segregation of multipartite genomes, where their role may thus be easier to evaluate. We have characterized parABS systems in Burkholderia cenocepacia, whose genome comprises three chromosomes and one low-copy-number plasmid. A single parAB locus and a set of ParB-binding (parS) centromere sites are located near the origin of each replicon. ParA and ParB of the longest chromosome are phylogenetically similar to analogues in other multichromosome and monochromosome bacteria but are distinct from those of smaller chromosomes. The latter form subgroups that correspond to the taxa of their hosts, indicating evolution from plasmids. The parS sites on the smaller chromosomes and the plasmid are similar to the “universal” parS of the main chromosome but with a sequence specific to their replicon. In an Escherichia coli plasmid stabilization test, each parAB exhibits partition activity only with the parS of its own replicon. Hence, parABS function is based on the independent partition of individual chromosomes rather than on a single communal system or network of interacting systems. Stabilization by the smaller chromosome and plasmid systems was enhanced by mutation of parS sites and a promoter internal to their parAB operons, suggesting autoregulatory mechanisms. The small chromosome ParBs were found to silence transcription, a property relevant to autoregulation. PMID:16452432
MODIS-derived daily PAR simulation from cloud-free images and its validation

Energy Technology Data Exchange (ETDEWEB)

Chen, Liangfu; Gu, Xingfa; Tian, Guoliang [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); The Center for National Spaceborne Demonstration, Beijing 100101 (China); Gao, Yanhua [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101 (China); Yang, Lei [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); Jilin University, Changchun 130026 (China); Liu, Qinhuo [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China)

2008-06-15

In this paper, a MODIS-derived daily PAR (photosynthetically active radiation) simulation model from cloud-free image over land surface has been developed based on Bird and Riordan's model. In this model, the total downwelling spectral surface irradiance is divided into two parts: one is beam irradiance, and another is diffuse irradiance. The attenuation of solar beam irradiance comprises scattering by the gas mixture, absorption by ozone, the gas mixture and water vapor, and scattering and absorption by aerosols. The diffuse irradiance is scattered out of the direct beam and towards the surface. The multiple ground-air interactions have been taken into account in the diffuse irradiance model. The parameters needed in this model are atmospheric water vapor content, aerosol optical thickness and spectral albedo ranging from 400 nm to 700 nm. They are all retrieved from MODIS data. Then, the instantaneous photosynthetically available radiation (IPAR) is integrated by using a weighted sum at each of the visible MODIS wavebands. Finally, a daily PAR is derived by integration of IPAR. In order to validate the MODIS-derived PAR model, we compared the field PAR measurements in 2003 and 2004 against the simulated PAR. The measurements were made at the Qianyanzhou ecological experimental station, Chinese Ecosystem Research Network. A total of 54 days of cloud-free MODIS L1B level images were used for the PAR simulation. Our results show that the simulated PAR is consistent with field measurements, where the correlation coefficient of linear regression between calculated PAR and measured PAR is 0.93396. However, there were some uncertainties in the comparison of 1 km pixel PAR with the tower flux stand measurement. (author)
PAR-2 expression in the gingival crevicular fluid reflects chronic periodontitis severity.

Science.gov (United States)

Fukushima, Henrique; Alves, Vanessa Tubero Euzebio; Carvalho, Verônica Franco de; Ambrósio, Lucas Macedo Batitucci; Eichler, Rosangela Aparecida Dos Santos; Carvalho, Maria Helena Catelli de; Saraiva, Luciana; Holzhausen, Marinella

2017-01-26

Recent studies investigating protease-activated receptor type 2 (PAR-2) suggest an association between the receptor and periodontal inflammation. It is known that gingipain, a bacterial protease secreted by the important periodontopathogen Porphyromonas gingivalis can activate PAR-2. Previous studies by our group found that PAR-2 is overexpressed in the gingival crevicular fluid (GCF) of patients with moderate chronic periodontitis (MP). The present study aimed at evaluating whether PAR-2 expression is associated with chronic periodontitis severity. GCF samples and clinical parameters, including plaque and bleeding on probing indices, probing pocket depth and clinical attachment level, were collected from the control group (n = 19) at baseline, and from MP patients (n = 19) and severe chronic periodontitis (SP) (n = 19) patients before and 6 weeks after periodontal non-surgical treatment. PAR-2 and gingipain messenger RNA (mRNA) in the GCF of 4 periodontal sites per patient were evaluated by Reverse Transcription Polymerase Chain Reaction (RT-qPCR). PAR-2 and gingipain expressions were greater in periodontitis patients than in control group patients. In addition, the SP group presented increased PAR-2 and gingipain mRNA levels, compared with the MP group. Furthermore, periodontal treatment significantly reduced (p periodontitis. In conclusion, PAR-2 is associated with chronic periodontitis severity and with gingipain levels in the periodontal pocket, thus suggesting that PAR-2 expression in the GCF reflects the severity of destruction during periodontal infection.
Molecular mechanism of bundle formation by the bacterial actin ParM

Energy Technology Data Exchange (ETDEWEB)

Popp, David, E-mail: dpopp@imcb.a-star.edu.sg [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, 138673 Singapore (Singapore); Narita, Akihiro [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Nagoya University Graduate School of Science, Structural Biology Research Center and Division of Biological Sciences, Furo-cho, Chikusa-ku, Nagoya 464-8601 (Japan); Iwasa, Mitsusada [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Maeda, Yuichiro [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Nagoya University Graduate School of Science, Structural Biology Research Center and Division of Biological Sciences, Furo-cho, Chikusa-ku, Nagoya 464-8601 (Japan); Robinson, Robert C. [Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, 138673 Singapore (Singapore)

2010-01-22

The actin homolog ParM plays a microtubule-like role in segregating DNA prior to bacterial cell division. Fluorescence and cryo-electron microscopy have shown that ParM forms filament bundles between separating DNA plasmids in vivo. Given the lack of ParM bundling proteins it remains unknown how ParM bundles form at the molecular level. Here we show using time-lapse TIRF microscopy, under in vitro molecular crowding conditions, that ParM-bundle formation consists of two distinct phases. At the onset of polymerization bundle thickness and shape are determined in the form of nuclei of short helically disordered filaments arranged in a liquid-like lattice. These nuclei then undergo an elongation phase whereby they rapidly increase in length. At steady state, ParM bundles fuse into one single large aggregate. This behavior had been predicted by theory but has not been observed for any other cytomotive biopolymer, including F-actin. We employed electron micrographs of ParM rafts, which are 2-D analogs of 3-D bundles, to identify the main molecular interfilament contacts within these suprastructures. The interface between filaments is similar for both parallel and anti-parallel orientations and the distribution of filament polarity is random within a bundle. We suggest that the interfilament interactions are not due to the interactions of specific residues but rather to long-range, counter ion mediated, electrostatic attractive forces. A randomly oriented bundle ensures that the assembly is rigid and that DNA may be captured with equal efficiency at both ends of the bundle via the ParR binding protein.
Par Pond vegetation status Summer 1995 -- October survey descriptive summary

International Nuclear Information System (INIS)

Mackey, H.E. Jr.; Riley, R.S.

1995-11-01

The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the emergent shoreline aquatic plant communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level and continued with this late October survey. Communities similar to the pre-drawdown Par Pond aquatic plant communities are becoming re-established; especially, beds of maiden cane, lotus, waterlily, and watershield are now extensive and well established. Cattail occurrence continues to increase, but large beds common to Par Pond prior to the drawdown have not formed. Future surveys throughout 1996 and 1997, along with the continued evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned
Par Pond vegetation status Summer 1995 -- September survey descriptive summary

International Nuclear Information System (INIS)

Mackey, H.E. Jr.; Riley, R.S.

1995-09-01

The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the emergent shoreline aquatic plant communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level and continued with this mid-September survey. Communities similar to the pre-drawdown Par Pond aquatic plant communities are becoming re-established; especially, beds of maidencane, lotus, waterlily, and watershield are now extensive and well established. Cattail occurrence continues to increase, but large beds common to Par Pond prior to the drawdown have not formed. Future surveys during the late growing seasons of 1995, and throughout 1996 and 1997, along with the evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned
Improved Satellite-based Photosysnthetically Active Radiation (PAR) for Air Quality Studies

Science.gov (United States)

Pour Biazar, A.; McNider, R. T.; Cohan, D. S.; White, A.; Zhang, R.; Dornblaser, B.; Doty, K.; Wu, Y.; Estes, M. J.

2015-12-01

One of the challenges in understanding the air quality over forested regions has been the uncertainties in estimating the biogenic hydrocarbon emissions. Biogenic volatile organic compounds, BVOCs, play a critical role in atmospheric chemistry, particularly in ozone and particulate matter (PM) formation. In southeastern United States, BVOCs (mostly as isoprene) are the dominant summertime source of reactive hydrocarbon. Despite significant efforts in improving BVOC estimates, the errors in emission inventories remain a concern. Since BVOC emissions are particularly sensitive to the available photosynthetically active radiation (PAR), model errors in PAR result in large errors in emission estimates. Thus, utilization of satellite observations to estimate PAR can help in reducing emission uncertainties. Satellite-based PAR estimates rely on the technique used to derive insolation from satellite visible brightness measurements. In this study we evaluate several insolation products against surface pyranometer observations and offer a bias correction to generate a more accurate PAR product. The improved PAR product is then used in biogenic emission estimates. The improved biogenic emission estimates are compared to the emission inventories over Texas and used in air quality simulation over the period of August-September 2013 (NASA's Discover-AQ field campaign). A series of sensitivity simulations will be performed and evaluated against Discover-AQ observations to test the impact of satellite-derived PAR on air quality simulations.
SAFARI 2000 PAR Measurements, Kalahari Transect, Botswana, Wet Season 2000

Data.gov (United States)

National Aeronautics and Space Administration — Ceptometer data from a Decagon AccuPAR (Model PAR-80) were collected at four sites in Botswana during the SAFARI 2000 Kalahari Transect Wet Season Campaign (March,...
Lumbar lordosis and pars interarticularis fractures: a case-control study

International Nuclear Information System (INIS)

Bugg, William G.; Lewis, Mark; Juette, Arne; Cahir, John G.; Toms, Andoni P.

2012-01-01

The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)

Lumbar lordosis and pars interarticularis fractures: a case-control study

Energy Technology Data Exchange (ETDEWEB)

Bugg, William G; Lewis, Mark; Juette, Arne; Cahir, John G; Toms, Andoni P [Cotman Centre, Norwich Radiology Academy, Norwich, Norfolk (United Kingdom)

2012-07-15

The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)
Lumbar lordosis and pars interarticularis fractures: a case-control study

Energy Technology Data Exchange (ETDEWEB)

Bugg, William G.; Lewis, Mark; Juette, Arne; Cahir, John G.; Toms, Andoni P. [Cotman Centre, Norwich Radiology Academy, Norwich, Norfolk (United Kingdom)

2012-07-15

The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)
Croissance epitaxiale de GaAs sur substrats de Ge par epitaxie par faisceaux chimiques

Science.gov (United States)

Belanger, Simon

La situation energetique et les enjeux environnementaux auxquels la societe est confrontee entrainent un interet grandissant pour la production d'electricite a partir de l'energie solaire. Parmi les technologies actuellement disponibles, la filiere du photovoltaique a concentrateur solaire (CPV pour concentrator photovoltaics) possede un rendement superieur et mi potentiel interessant a condition que ses couts de production soient competitifs. La methode d'epitaxie par faisceaux chimiques (CBE pour chemical beam epitaxy) possede plusieurs caracteristiques qui la rendent interessante pour la production a grande echelle de cellules photovoltaiques a jonctions multiples a base de semi-conducteurs III-V. Ce type de cellule possede la meilleure efficacite atteinte a ce jour et est utilise sur les satellites et les systemes photovoltaiques a concentrateur solaire (CPV) les plus efficaces. Une des principales forces de la technique CBE se trouve dans son potentiel d'efficacite d'utilisation des materiaux source qui est superieur a celui de la technique d'epitaxie qui est couramment utilisee pour la production a grande echelle de ces cellules. Ce memoire de maitrise presente les travaux effectues dans le but d'evaluer le potentiel de la technique CBE pour realiser la croissance de couches de GaAs sur des substrats de Ge. Cette croissance constitue la premiere etape de fabrication de nombreux modeles de cellules solaires a haute performance decrites plus haut. La realisation de ce projet a necessite le developpement d'un procede de preparation de surface pour les substrats de germanium, la realisation de nombreuses sceances de croissance epitaxiale et la caracterisation des materiaux obtenus par microscopie optique, microscopie a force atomique (AFM), diffraction des rayons-X a haute resolution (HRXRD), microscopie electronique a transmission (TEM), photoluminescence a basse temperature (LTPL) et spectrometrie de masse des ions secondaires (SIMS). Les experiences ont permis
The cryogenic installations for irradiation in the reactors Melusine and Siloe; Les installations cryogeniques pour irradiations des reacteurs Melusine et Siloe

Energy Technology Data Exchange (ETDEWEB)

Bochirol, L; Le Calvez, J; Doulat, J; Verdier, J; Lacaze, A; Weil, L [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1964-07-01

vaporized in the atmosphere and without any pollution of the refrigerating circuit. Lastly, a few words are said about the liquid helium loop, a prototype of which has worked, and which is being rebuilt with an increased power. (authors) [French] L'etude des defauts crees par l'irradiation dans les solides est d'un interet theorique et pratique, considerable. L'irradiation a basse temperature permet d'obtenir les defauts dans leur etat le plus simple, leur etat 'primaire' sans que l'agitation thermique permette leur annihilation ou leur rearrangement. L'irradiation en pile a basse temperature pose un certain nombre de problemes techniques provenant de la puissance de refrigeration necessaire, qui est quelquefois considerable, des reactions chimiques possibles sous rayonnement et du manque d'espace dans un reacteur. Enfin, la necessite de faire toute l'irradiation et les mesures ulterieures sans rechauffer les; echantillons impose que le dispositif fonctionne en continu sans defaillance et qu'il soit equipe de facon a permettre la recuperation des echantillons froids, ou bien leur mesure et leur rechauffage controle 'in situ'. On decrit la facon dont ces problemes ont ete resolus a Grenoble, pour des dispositifs d'irradiation a 78 deg. K, 28 deg. K et 4 deg. K dans les deux piles piscines Melusine et Siloe. Quelques resultats d'exploitation sont donnes sur la boucle a azote liquide, dite type A, qui fonctionne depuis plusieurs annees dans Melusine. En particulier certaines observations sont faites sur les reactions chimiques qui peuvent se produire sous irradiation dans l'azote liquide impur. On decrit assez en detail la boucle a azote liquide, dite type A, qui vient d'etre installee dans le reacteur Siloe. Les traits essentiels de cet appareil sont: qu'il permet l'irradiation dans des flux plus eleves que le precedent et que son exploitation est grandement facilitee grace a un mode de realisation qui permet l'acces aux echantillons sans demontage ni deconnexion de l
ParTIES: a toolbox for Paramecium interspersed DNA elimination studies.

Science.gov (United States)

Denby Wilkes, Cyril; Arnaiz, Olivier; Sperling, Linda

2016-02-15

Developmental DNA elimination occurs in a wide variety of multicellular organisms, but ciliates are the only single-celled eukaryotes in which this phenomenon has been reported. Despite considerable interest in ciliates as models for DNA elimination, no standard methods for identification and characterization of the eliminated sequences are currently available. We present the Paramecium Toolbox for Interspersed DNA Elimination Studies (ParTIES), designed for Paramecium species, that (i) identifies eliminated sequences, (ii) measures their presence in a sequencing sample and (iii) detects rare elimination polymorphisms. ParTIES is multi-threaded Perl software available at https://github.com/oarnaiz/ParTIES. ParTIES is distributed under the GNU General Public Licence v3. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
Effect of simvastatin and ezetimibe on suPAR levels and outcomes

DEFF Research Database (Denmark)

Hodges, Gethin W; Bang, Casper N; Forman, Julie L

2018-01-01

-lowering therapy also lowers suPAR levels is unknown. METHODS: We investigated whether treatment with Simvastatin 40 mg and Ezetimibe 10 mg lowered plasma suPAR levels in 1838 patients with mild-moderate, asymptomatic aortic stenosis, included in the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study, using...... and Ezetimibe treatment impeded the progression of the time-related increase in plasma suPAR levels. Year-1 suPAR was associated with all-cause mortality, MCE, and AVE irrespective of baseline levels (SEAS study: NCT00092677)....... cardiovascular events (MCE) composed of ischemic cardiovascular events (ICE) and aortic valve related events (AVE). RESULTS: After 4.3 years of follow-up, suPAR levels had increased by 9.2% (95% confidence interval [CI]: 7.0%-11.5%) in the placebo group, but only by 4.1% (1.9%-6.2%) in the group with lipid...
Paracrine Apoptotic Effect of p53 Mediated by Tumor Suppressor Par-4

Directory of Open Access Journals (Sweden)

Ravshan Burikhanov

2014-01-01

Full Text Available The guardian of the genome, p53, is often mutated in cancer and may contribute to therapeutic resistance. Given that p53 is intact and functional in normal tissues, we harnessed its potential to inhibit the growth of p53-deficient cancer cells. Specific activation of p53 in normal fibroblasts selectively induced apoptosis in p53-deficient cancer cells. This paracrine effect was mediated by p53-dependent secretion of the tumor suppressor Par-4. Accordingly, the activation of p53 in normal mice, but not p53−/− or Par-4−/− mice, caused systemic elevation of Par-4, which induced apoptosis of p53-deficient tumor cells. Mechanistically, p53 induced Par-4 secretion by suppressing the expression of its binding partner, UACA, which sequesters Par-4. Thus, normal cells can be empowered by p53 activation to induce Par-4 secretion for the inhibition of therapy-resistant tumors.
Efficacy and safety of the pars plana clip in the Ahmed valve device inserted via the pars plana in patients with refractory glaucoma

Directory of Open Access Journals (Sweden)

Manuel Diaz-Llopis

2010-05-01

Full Text Available Manuel Diaz-Llopis1,2,3, David Salom1,3, Salvador García-Delpech1,2,3, Patricia Udaondo1,3, Jose Maria Millan3,5, J Fernando Arevalo61Department of Ophthalmology, La Fe University Hospital of Valencia, Valencia, Spain; 2Department of Ophthalmology of the Valencia University, Valencia, Spain; 3Biomedical Network Research Centre on Rare Diseases (CIBERER, Valencia, Spain; 4Catholic University San Vicente Martir, Valencia, Spain; 5Department of Genetics, La Fe University Hospital of Valencia, Valencia, Spain; 6Clinica Oftalmologica Centro Caracas, Retina and VItreous Service, Caracas, DC, VenezuelaPurpose: To evaluate the efficacy and safety of the pars plana clip (PPC in the Ahmed valve tube inserted via the pars plana in patients with secondary refractory glaucomas.Methods: Prospective and interventional case series that included 10 patients with secondary refractory glaucoma. The pars plana vitrectomy and the implant of the modified tube were performed during the same surgery. Control of intraocular pressure (IOP and the development of intra- and postoperative complications were evaluated during the follow-up.Results: Follow-up time was twelve months in all the patients. Control of IOP was achieved in 90% of patients, and 70% needed no antiglaucoma treatment. The complications that occurred were transient hypotony in three cases, choroidal detachment in two cases, and one case of intraocular hemorrhage. No case of tube extrusion or tube kink was observed.Conclusions: Our data suggests that implantation of the Ahmed tube modified with the PPC via the pars plana is safe and effective in patients with secondary refractory glaucomas. Keywords: pars plana clip, Ahmed valve, refractory glaucoma, pars plana vitrectomy
Effects of solar PAR and UV radiation on tropical biofouling communities

KAUST Repository

Dobretsov, SV

2010-03-08

We investigated the effect of solar ultraviolet radiation (UVR) and photosynthetically active radiation (PAR) on the development of tropical micro- and macrofouling communities for 30 d. The experimental design involved 3 treatments: full spectrum (PAR+UVR), PAR only, and minimal light (reduced PAR and UVR). Terminal restriction fragment length polymorphism analysis demonstrated that different light conditions resulted in the formation of highly different microbial communities. The lowest densities of bacteria were found under the full spectrum treatment, while the lowest densities of diatoms were found in the minimal light treatment. Macrofouling communities consisted of 13 species and differed among light treatments. In the presence of UVR, communities had low species diversity, evenness, and richness, while in minimal light and PAR treatments, communities had high species diversity, evenness, and richness. Similarity percentage (SIMPER) analysis revealed that the tubeworm Hydroides elegans, the alga Ulva (Enteromorpha) sp., and the bivalve Perna viridis were the species responsible for most of the dissimilarities in macrofouling communities among treatments. While densities of H. elegans were similar in the PAR and minimal light treatments, this polychaete had higher growth rates under minimal light conditions. We conclude that UVR and PAR directly control the development of shallow micro- and macrofouling communities by inhibiting the recruitment and growth of sensitive species and promoting the growth of resistant species, but also that these forms of solar radiation influence the surface cues available to competent larvae by altering the development of the microbial community.
Paternal age related schizophrenia (PARS): Latent subgroups detected by k-means clustering analysis.

Science.gov (United States)

Lee, Hyejoo; Malaspina, Dolores; Ahn, Hongshik; Perrin, Mary; Opler, Mark G; Kleinhaus, Karine; Harlap, Susan; Goetz, Raymond; Antonius, Daniel

2011-05-01

Paternal age related schizophrenia (PARS) has been proposed as a subgroup of schizophrenia with distinct etiology, pathophysiology and symptoms. This study uses a k-means clustering analysis approach to generate hypotheses about differences between PARS and other cases of schizophrenia. We studied PARS (operationally defined as not having any family history of schizophrenia among first and second-degree relatives and fathers' age at birth ≥ 35 years) in a series of schizophrenia cases recruited from a research unit. Data were available on demographic variables, symptoms (Positive and Negative Syndrome Scale; PANSS), cognitive tests (Wechsler Adult Intelligence Scale-Revised; WAIS-R) and olfaction (University of Pennsylvania Smell Identification Test; UPSIT). We conducted a series of k-means clustering analyses to identify clusters of cases containing high concentrations of PARS. Two analyses generated clusters with high concentrations of PARS cases. The first analysis (N=136; PARS=34) revealed a cluster containing 83% PARS cases, in which the patients showed a significant discrepancy between verbal and performance intelligence. The mean paternal and maternal ages were 41 and 33, respectively. The second analysis (N=123; PARS=30) revealed a cluster containing 71% PARS cases, of which 93% were females; the mean age of onset of psychosis, at 17.2, was significantly early. These results strengthen the evidence that PARS cases differ from other patients with schizophrenia. Hypothesis-generating findings suggest that features of PARS may include a discrepancy between verbal and performance intelligence, and in females, an early age of onset. These findings provide a rationale for separating these phenotypes from others in future clinical, genetic and pathophysiologic studies of schizophrenia and in considering responses to treatment. Copyright © 2011 Elsevier B.V. All rights reserved.
Par Pond vegetation status Summer 1995 -- June survey descriptive summary

International Nuclear Information System (INIS)

Mackey, H.E. Jr.; Riley, R.S.

1995-06-01

The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the shoreline aquatic plant communities in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level, indicated that much of the original plant communities and the intermediate shoreline communities present on the exposed sediments have been lost. The extensive old-field and emergent marsh communities that were present on the exposed shoreline during the drawdown have been flooded and much of the pre-drawdown Par Pond aquatic plant communities have not had sufficient time for re-establishment. The shoreline does, however, have extensive beds of maidencane which extend from the shoreline margin to areas as deep as 2 and perhaps 3 meters. Scattered individual plants of lotus and watershield are common and may indicate likely directions of future wetland development in Par Pond. In addition, within isolated coves, which apparently received ground water seepage and/or stream surface flows during the period of the Par Pond draw down, extensive beds of waterlilies and spike rush are common. Invasion of willow and red maple occurred along the lake shoreline as well. Although not absent from this survey, evidence of the extensive redevelopment of the large cattail and eel grass beds was not observed in this first survey of Par Pond. Future surveys during the growing seasons of 1995, 1996, and 1997 along with the evaluation of satellite date to map the areal extent of the macrophyte beds of Par Pond are planned
Apparatus of irradiation of steel test pieces in the Marcoule pile G 1; Dispositifs d'irradiation d'eprouvettes d'acier dans la pile G 1 de Marcoule

Energy Technology Data Exchange (ETDEWEB)

Marinot, R; Wallet, Ph [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

1960-07-01

Test pieces of steel were irradiated in the reactor G1 at Marcoule, in convectors replacing fuel elements, and in vertical channels in furnace-heated containers. The apparatus designed for this irradiation is described: containers, converter-rods, suspension fixtures and clamps, temperature measurement devices, lead castles and unloading set-ups. (author) [French] Des eprouvettes d'acier ont ete irradiees dans le reacteur G1 de Marcoule dans des convertisseurs mis a la place d'elements combustibles, et dans des canaux verticaux, en conteneurs chauffes par four. Nous decrivons l'appareillage etudie pour cette irradiation: conteneurs, barreaux-convertisseurs, dispositifs de suspension et d'amarrage, dispositifs de regulation et de mesure de temperature, chateaux de plomb et montages de defournement. (auteur)
Characteristics and construction problems of EL 4; Caracteristiques et problemes de construction d'EL4

Energy Technology Data Exchange (ETDEWEB)

Carle, R; Schulhof, P [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires; Sevin, Ph [Electricite de France (EDF), 75 - Paris (France); Buttin, J [Societe INDATOM (France)

1964-07-01

detail and the connections to be employed were tested. The whole circuit is made in fairly classical materials (slightly alloyed steels) whose behaviour in the carbon dioxyde at 500 deg. C was proved. The CO{sub 2}, and heavy water circuits construction will begin in October 1964. Aerodynamic tests were carried out for the helico-centrifugal blowers (of unit power 9 MW). The choice of a pressure as high as 60 kg/cm{sup 2} does not seem to induce new problems in connection with leaks on the machine shafts. Finally, the choice of a type of CO{sub 2} - steam heat exchanger with forced circulation led Electricite de France to test the operation and stability of a prototype exchanger in its test plant The reactor will be equipped with a de-pressurizing and de-superheating system which will allow the reactor to operate at 20 p. 100 of its nominal power whether the turbo-alternator is available or not. (authors) [French] EL 4 est le prototype d'une filiere originale de reacteurs moderes a l'eau lourde et refroidis au gaz carbonique. Son etude a ete menee dans la double optique de: - realiser un reacteur suffisamment important et complet pour y tester l'ensemble des problemes de construction et d'exploitation de la filiere; - menager dans l'installation les possibilites de tenir compte des ameliorations (materiaux nouveaux, elements combustibles ameliores) qui sont etudiees par ailleurs. Le premier objectif n'etait envisageable que sous reserve d'un volume d'etudes preliminaires important. A ce titre, ont ete realises et essayes de 1962 a 1964 plusieurs canaux prototypes, hors pile, mais dans les conditions reelles de temperature et de pression. Ces essais ont montre la bonne tenue des materiaux aux difficiles conditions mecaniques et chimiques du projet. Ces installations seront d'ailleurs disponibles pour eprouver, avant mise en pile, les modifications ulterieures. D'importants essais touchant la securite du reacteur en cas d'explosion du circuit de CO{sub 2}, ont ete realises
[Ambroise Paré, his death and his historians].

Science.gov (United States)

Dumaître, P

2001-01-01

Ambroise Paré died December the 20th., 1590. What happened after his death and what are we knowing about his life? Never forgotten, though a lack of care, we were waiting till the XIXth. century to get recollection upon a subject sustained only by accounts of his travels. After Percy, a surgeon who tried to write Paré's biography through the "Biographie universelle ancienne et moderne, de Michaud (1822)" and some second rank authors, Malgaigne is the first who inside a printing of the "Oeuvres complétes de Paré (1840-41)" has a fine look upon the question, though his work is incomplete and allows many mistakes. Doctors Chéreau and Jal, an historian, analysing civil status records, gave new information enlarged by doctors Le Paulmier, Turner and the U.S. native Janet Doe.
Bacterial mitosis: Partitioning protein ParA oscillates in spiral-shaped structures and positions plasmids at mid-cell

DEFF Research Database (Denmark)

Ebersbach, G.; Gerdes, Kenn

2004-01-01

The par2 locus of Escherichia coli plasmid pB171 encodes oscillating ATPase ParA, DNA binding protein ParB and two cis-acting DNA regions to which ParB binds (parC1 and parC2). Three independent techniques were used to investigate the subcellular localization of plasmids carrying par2. In cells......A-GFP oscillated in spiral-shaped structures. Amino acid substitutions in ParA simultaneously abolished ParA spiral formation, oscillation and either plasmid localization or plasmid separation at mid-cell. Therefore, our results suggest that ParA spirals position plasmids at the middle of the bacterial nucleoid...
Recent progress in the detection of bursts in the canning in French reactors; Progres recents de la detection des ruptures de gaines dans les reacteurs francais G1, EL2, G3, EL3

Energy Technology Data Exchange (ETDEWEB)

Goupil, J; Grenon, M; Raffailhac, J; Roguin, A [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1959-07-01

des produits de fission, 2) de la pollution d'uranium des gaines et de la pollution eventuelle des canaux apres ruptures de gaines rapides. L'evolumetre est constitue par une memoire qui stocke les valeurs de l'activite des canaux prises a un instant considere comme reference. A cette memoire, on vient comparer les valeurs de l'activite des canaux en cours de prospection. Une difference entre ces valeurs indique l'apparition ou l'evolution d'une fissure de gaine. Pour tenir compte des variations du regime thermodynamique dans les canaux, les valeurs extraites de la memoire sont corrigees par un signal provenant d'un detecteur d'activite place dans le circuit general de sortie du gaz de la pile. Dans le cas de la pile EL{sub 2}, egalement a refroidissement par CO{sub 2}, sous pression, une methode analogue a celle de G{sub 3} a ete utilisee. Des echantillons de gaz de refroidissement sont preleves dans chacune des 133 cellules de la pile successivement par l'ouverture d'electrovannes. Le gaz est filtre et les produits de fission sont extraits par une methode de collection electrostatique. Un scintillateur et une chaine electronique fournissent un signal specifique des produits de fission qui s'inscrit sur un enregistreur. Dans le cas d'un depassement du seuil d'activite, la cellule incriminee est isolee du systeme de prospection et prise en charge par un detecteur 'suiveur' qui permet de suivre l'evolution de la fissure. Une annee d'exploitation de la pile G1 qui est refroidie a l'air a la pression atmospherique a permis d'obtenir des resultats sur le fonctionnement du dispositif D.R.G. ce qui nous a amenes a perfectionner le dispositif initial en installant un evolumetre du type decrit ci-dessus pour G{sub 3}. Le reacteur EL{sub 3}, refroidi a l'eau lourde, utilise un systeme de detection base sur la mesure, au moyen de compteurs G.M., de l'activite des gaz de fission entraines par de l'helium dilue dans l'eau lourde puis extraits de celle-ci par des hydrocyclones. La
Indium-Gallium Radiation Contour of the IRT Nuclear Reactor; Circuit d'activation d'indium-gallium dans le reacteur nucleaire IRT; Indij-gallievyj radiatsionnyj kontur yadernogo reaktora IRT; Circuito de radiaciones de indio-galio del reactor IRT

Energy Technology Data Exchange (ETDEWEB)

Breger, A K; Ryabukin, Y S; Tulkes, S G; Volkov, E N

1960-07-15

Following on theoretical work already published, an indium-gallium radiation contour of the IRT nuclear reactor has been prepared, and represents a powerful new source of gamma-radiation. The first contour of this type ''RK-1'' was prepared on the IRT reactor at the Physics Institute of the Academy of Sciences of the Georgian SSR. The paper gives the activation calculations for indium-gallium alloy; the structural components of RK-1 and their arrangement in the reactor tank and the hot cell; the devise for feeding liquid and gaseous substances into the irradiation zone; and the conveyor for solid substances to be irradiated. When the IRT reactor is at a power of 2000 kW, the radiation strength of the contour is equivalent to that of a gamma-emitter having an activity of 20,000 g. Ra equivalent. The prospects for the use of the indium-gallium radiation contour for research and semi-industrial purposes are discussed. (author) [French] A la suite de la publication d'un ouvrage theorique, on a etabli autour du reacteur nucleaire IRT un circuit d'activation d'indium-gallium qui represente une nouvelle source de rayonnements gamma de grande intensite. Le premier circuit de ce type ''RK-1'' a ete etabli sur le reacteur IRT a l'Institut de physique de l'Academie des sciences de la RSS de Georgie. Les auteurs donnent les calculs de l'activation pour l'alliage indium-gallium; ils indiquent les elements structurels du RK-1 et leur disposition dans le reservoir et dans la cellule de haute activite du reacteur; ils decrivent le dispositif permettant d'introduire des substances liquides et gazeuses dans la zone d'irradiation et le systeme qui transporte les substances solides a irradier. Lorsque le reacteur IRT fonctionne a 2 000 kW, la puissance de rayonnement du circuit equivaut a celle d'un emetteur gamma ayant une activite equivalente a 20 000 grammes de radium. Les auteurs examinent les perspectives d'emploi de ce processus pour la recherche et a des fins semi
TMS suppression of right pars triangularis, but not pars opercularis, improves naming in aphasia

Science.gov (United States)

Naeser, Margaret A.; Martin, Paula I.; Theoret, Hugo; Kobayashi, Masahito; Fregni, Felipe; Nicholas, Marjorie; Tormos, Jose M.; Steven, Megan S.; Baker, Errol H.; Pascual-Leone, Alvaro

2011-01-01

This study sought to discover if an optimum 1 cm2 area in the non-damaged right hemisphere (RH) was present, which could temporarily improve naming in chronic, nonfluent aphasia patients when suppressed with repetitive transcranial magnetic stimulation (rTMS). Ten minutes of slow, 1 Hz rTMS was applied to suppress different RH ROIs in eight aphasia cases. Picture naming and response time (RT) were examined before, and immediately after rTMS. In aphasia patients, suppression of right pars triangularis (PTr) led to significant increase in pictures named, and significant decrease in RT. Suppression of right pars opercularis (POp), however, led to significant increase in RT, but no change in number of pictures named. Eight normals named all pictures correctly; similar to aphasia patients, RT significantly decreased following rTMS to suppress right PTr, versus right POp. Differential effects following suppression of right PTr versus right POp suggest different functional roles for these regions. PMID:21864891
First-in-human uPAR PET: Imaging of Cancer Aggressiveness

Science.gov (United States)

Persson, Morten; Skovgaard, Dorthe; Brandt-Larsen, Malene; Christensen, Camilla; Madsen, Jacob; Nielsen, Carsten H.; Thurison, Tine; Klausen, Thomas Levin; Holm, Søren; Loft, Annika; Berthelsen, Anne Kiil; Ploug, Michael; Pappot, Helle; Brasso, Klaus; Kroman, Niels; Højgaard, Liselotte; Kjaer, Andreas

2015-01-01

A first-in-human clinical trial with Positron Emission Tomography (PET) imaging of the urokinase-type plasminogen activator receptor (uPAR) in patients with breast, prostate and bladder cancer, is described. uPAR is expressed in many types of human cancers and the expression is predictive of invasion, metastasis and indicates poor prognosis. uPAR PET imaging therefore holds promise to be a new and innovative method for improved cancer diagnosis, staging and individual risk stratification. The uPAR specific peptide AE105 was conjugated to the macrocyclic chelator DOTA and labeled with 64Cu for targeted molecular imaging with PET. The safety, pharmacokinetic, biodistribution profile and radiation dosimetry after a single intravenous dose of 64Cu-DOTA-AE105 were assessed by serial PET and computed tomography (CT) in 4 prostate, 3 breast and 3 bladder cancer patients. Safety assessment with laboratory blood screening tests was performed before and after PET ligand injection. In a subgroup of the patients, the in vivo stability of our targeted PET ligand was determined in collected blood and urine. No adverse or clinically detectable side effects in any of the 10 patients were found. The ligand exhibited good in vivo stability and fast clearance from plasma and tissue compartments by renal excretion. In addition, high uptake in both primary tumor lesions and lymph node metastases was seen and paralleled high uPAR expression in excised tumor tissue. Overall, this first-in-human study therefore provides promising evidence for safe use of 64Cu-DOTA-AE105 for uPAR PET imaging in cancer patients. PMID:26516369
Rat beta-LPH, gamma-LPH and beta-endorphin biosynthesized by isolated cells of pars intermedia and pars distalis

International Nuclear Information System (INIS)

Gianoulakis, C.; Seidah, N.G.; Routhier, R.; Chretien, M.

1980-01-01

Rats pars intermedia cells were incubated for 3 h with the following amino-acids: a) 35 S-methionine and 3 H-phenylalamine; b) 3 H-valine; and c) 3 H-valine and 3 H-lysine. Radioactive gamma-lipotropin, beta-lipotropin and beta-endorphin were purified on carboxy- methyl-cellulose and characterized by polyacrylamide disc gel electrophoresis af pH 4.5, molecular weight estimation and microsequencing. Rat gamma-lipotropin was shown to differ slightly from ovine gamma-lipotropin in its NH 2 -terminal amino acid sequence, in containing no methionine and having phenylalanine at position 6, valine at positions 13 and 27, and lysine at position 20. The same variations were observed in the sequence of rat beta-lipotropin, while rat beta-endorphin was shown to be identical to the ovine beta-endorphin. Following a 3-h pulse of rat pars distalis, the cells were extracted with care to avoid beta-lipotropin degradation by proteolytic enzymes. A peptide was purified and identified to be rat beta-endorphin, thus demonstrating that beta-endorphin is biosynthesized in pars distalis and is not an extraction artifact. (author)

Identification of a new epitope in uPAR as a target for the cancer therapeutic monoclonal antibody ATN-658, a structural homolog of the uPAR binding integrin CD11b (αM.

Directory of Open Access Journals (Sweden)

Xiang Xu

Full Text Available The urokinase plasminogen activator receptor (uPAR plays a role in tumor progression and has been proposed as a target for the treatment of cancer. We recently described the development of a novel humanized monoclonal antibody that targets uPAR and has anti-tumor activity in multiple xenograft animal tumor models. This antibody, ATN-658, does not inhibit ligand binding (i.e. uPA and vitronectin to uPAR and its mechanism of action remains unclear. As a first step in understanding the anti-tumor activity of ATN-658, we set out to identify the epitope on uPAR to which ATN-658 binds. Guided by comparisons between primate and human uPAR, epitope mapping studies were performed using several orthogonal techniques. Systematic site directed and alanine scanning mutagenesis identified the region of aa 268-275 of uPAR as the epitope for ATN-658. No known function has previously been attributed to this epitope Structural insights into epitope recognition were obtained from structural studies of the Fab fragment of ATN-658 bound to uPAR. The structure shows that the ATN-658 binds to the DIII domain of uPAR, close to the C-terminus of the receptor, corroborating the epitope mapping results. Intriguingly, when bound to uPAR, the complementarity determining region (CDR regions of ATN-658 closely mimic the binding regions of the integrin CD11b (αM, a previously identified uPAR ligand thought to be involved in leukocyte rolling, migration and complement fixation with no known role in tumor progression of solid tumors. These studies reveal a new functional epitope on uPAR involved in tumor progression and demonstrate a previously unrecognized strategy for the therapeutic targeting of uPAR.
The protein kinase SIK downregulates the polarity protein Par3

DEFF Research Database (Denmark)

Vanlandewijck, Michael; Dadras, Mahsa Shahidi; Lomnytska, Marta

2018-01-01

on Par3. Functionally, this mechanism impacts on tight junction downregulation. Furthermore, SIK contributes to the loss of epithelial polarity and examination of advanced and invasive human cancers of diverse origin displayed high levels of SIK expression and a corresponding low expression of Par3...
PET imaging of urokinase-type plasminogen activator receptor (uPAR) in prostate cancer

DEFF Research Database (Denmark)

Skovgaard, Dorthe; Persson, Morten; Kjaer, Andreas

2016-01-01

Overexpression of urokinase-type plasminogen activator receptors (uPAR) represents an important biomarker for aggressiveness in most common malignant diseases, including prostate cancer (PC). Accordingly, uPAR expression either assessed directly in malignant PC tissue or assessed directly in plasma...... and prognostic imaging method. In this review, we will focus on the recent development of uPAR PET and the relevance within prostate cancer imaging. Novel antibody and small-molecule radiotracers-targeting uPAR, including a series of uPAR-targeting PET ligands, based on the high affinity peptide ligand AE105......, have been synthesized and tested in vitro and in vivo in preclinical murine xenograft models and, recently, in a first-ever clinical uPAR PET study in cancer patients, including patients with PC. In this phase I study, a high and specific uptake of the tracer 64Cu-DOTA-AE105 was found in both primary...
Par3L enhances colorectal cancer cell survival by inhibiting Lkb1/AMPK signaling pathway

International Nuclear Information System (INIS)

Li, Taiyuan; Liu, Dongning; Lei, Xiong; Jiang, Qunguang

2017-01-01

Partitioning defective 3-like protein (Par3L) is a recently identified cell polarity protein that plays an important role in mammary stem cell maintenance. Previously, we showed that high expression of Par3L is associated with poor survival in malignant colorectal cancer (CRC), but the underlying mechanism remained unknown. To this end, we established a Par3L knockout colorectal cancer cell line using the CRISPR/Cas system. Interestingly, reduced proliferation, enhanced cell death and caspase-3 activation were observed in Par3L knockout (KO) cells as compared with wildtype (WT) cells. Consistent with previous studies, we showed that Par3L interacts with a tumor suppressor protein liver kinase B1 (Lkb1). Moreover, Par3L depletion resulted in abnormal activation of Lkb1/AMPK signaling cascade. Knockdown of Lkb1 in these cells could significantly reduce AMPK activity and partially rescue cell death caused by Par3L knockdown. Furthermore, we showed that Par3L KO cells were more sensitive to chemotherapies and irradiation. Together, these results suggest that Par3L is essential for colorectal cancer cell survival by inhibiting Lkb1/AMPK signaling pathway, and is a putative therapeutic target for CRC. - Highlights: • Par3L knockout using the CRISPR/Cas system induces apoptosis in colorectal cancer cells. • Par3L interacts with Lkb1 and regulates the activity of AMPK signaling cascade. • Par3L knockout cells are more sensitive to treatment of different chemotherapy drugs and irradiation.
Profils des enfants infectes par le vih en debut du traitement ...

African Journals Online (AJOL)

But : Décrire les profils des enfants infectés par le VIH au début du traitement antirétroviral. Matériels et méthode: Les dossiers des enfants infectés par le VIH dans la région maritime ont été analysés de mai 2008 à février 2010 par le comité thérapeutique. Résultats: Parmi les 96 dossiers analysés, 66,67% venaient du ...
Brief communication: Population variation in human maxillary premolar accessory ridges (MxPAR).

Science.gov (United States)

Burnett, Scott E; Hawkey, Diane E; Turner, Christy G

2010-02-01

The purpose of this brief communication is to report the results of an analysis of maxillary premolar accessory ridges (MxPAR), a common but understudied accessory ridge that may occur both mesial and distal to the central ridge of the buccal cusp of upper premolars. We developed a new five-grade scoring plaque to better categorize MxPAR variation. Subsequently, we conducted a population analysis of MxPAR frequency in 749 dental casts of South African Indian, American Chinese, Alaskan Eskimo, Tohono O'odham (Papago), Akimel O'odham (Pima), Solomon Islander, South African Bantu, and both American and South African Whites. Northeast Asian and Asian-derived populations exhibited the highest MxPAR frequencies while Indo-European samples (South African Indians, American and South African Whites) exhibited relatively low frequencies. The Solomon Islanders and South African Bantu samples exhibited intermediate frequencies. Our analysis indicates that statistically significant differences in MxPAR frequency exist between major geographic populations. As a result, the MxPAR plaque has now been added to the Arizona State University Dental Anthropology System, an important contribution as maxillary premolar traits are underrepresented in analyses of dental morphology. 2009 Wiley-Liss, Inc.
Intoxication par la paraphényléne-diamine

African Journals Online (AJOL)

raoul

9 mars 2011 ... remède contre la douleur par Averbukh [8], ou contre la constipation par Schemesh [9], mais l´utilisation à des fins autolytique reste toujours prédominante. Le tableau clinique de l´intoxication à ... une anurie ayant nécessité le recours à l´hémodialyse. Ce taux de survenue d´IRA anurique est relativement ...
Reactor Radiation Loops as Large Gamma Sources; Boucles d'irradiation des reacteurs nucleaires utilisees comme sources gamma intenses; Radiatsionnye kontury yadernykh reaktorov kak moshchnye gamma-istochniki; Empleo de circuitos de irradiacion de los reactores como fuentes gamma de gran intensidad

Energy Technology Data Exchange (ETDEWEB)

Ryabukhina, Yu. S.

1963-11-15

Since 1957, study and research on the' production of radiation loops has been going on in the Soviet Union. Methods for calculating such systems were worked out and the possibilities of various gamma carriers examined. Indium alloy loops, liquid at room temperature, were first selected for practical experiment. The behaviour of two eutectic indium alloys was studied in relation to certain constructional materials and at the beginning of 1960 the first test indium-gallium loop was operated. Further work led to the installation of a model indium-gallium loop in the IRT reactor of the Georgian SSR Academy of Sciences with an irradiation source activity of 100 g Ra equivalent and a test In-Ga-Sn loop in a channel of the IRT reactor at the Institute of Atomic Energy, USSR Academy of Sciences. Finally in 1962, a pilot In-Ga-Sn loop for semi-industrial radiation processes was put into service in the IRT reactor of the Latvian SSR Academy of Sciences; its maximum irradiation source activity was 30 000 g Ra equivalent. The paper has the following sections: (1) ''Radiation loop calculation'', summarizing the work done on the computation techniques involved. (2) ''A model In-Ga radiation loop for the IRT-2000 reactor in Tbilisi'', describing the loop in operation. (3) ''An In-Ga-Sn radiation loop for the Latvian SSR Academy of Sciences IRT Reactor'', describing the loop in operation. (4) ''Possibilities of further radiation loop development'', describing experiments and systems and giving calculations on the basis of which it is considered possible to build hard manganese and mobile liquid indium-alloy loops. (author) [French] Depuis 1957, on execute en Union sovietique des travaux en vue d'etudier et de construire des boucles d'irradiation. On a elabore des methodes permettant de les calculer et d'examiner les possibilites offertes par differents emetteurs gamma. Le choix a porte tout d'abord sur les boucles utilisant des alliages liquides d'indium a la temperature ambiante
Profiling gene expression induced by protease-activated receptor 2 (PAR2 activation in human kidney cells.

Directory of Open Access Journals (Sweden)

Jacky Y Suen

Full Text Available Protease-Activated Receptor-2 (PAR2 has been implicated through genetic knockout mice with cytokine regulation and arthritis development. Many studies have associated PAR2 with inflammatory conditions (arthritis, airways inflammation, IBD and key events in tumor progression (angiogenesis, metastasis, but they have relied heavily on the use of single agonists to identify physiological roles for PAR2. However such probes are now known not to be highly selective for PAR2, and thus precisely what PAR2 does and what mechanisms of downstream regulation are truly affected remain obscure. Effects of PAR2 activation on gene expression in Human Embryonic Kidney cells (HEK293, a commonly studied cell line in PAR2 research, were investigated here by comparing 19,000 human genes for intersecting up- or down-regulation by both trypsin (an endogenous protease that activates PAR2 and a PAR2 activating hexapeptide (2f-LIGRLO-NH(2. Among 2,500 human genes regulated similarly by both agonists, there were clear associations between PAR2 activation and cellular metabolism (1,000 genes, the cell cycle, the MAPK pathway, HDAC and sirtuin enzymes, inflammatory cytokines, and anti-complement function. PAR-2 activation up-regulated four genes more than 5 fold (DUSP6, WWOX, AREG, SERPINB2 and down-regulated another six genes more than 3 fold (TXNIP, RARG, ITGB4, CTSD, MSC and TM4SF15. Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4 known to be important in cancer. This is the first widespread profiling of specific activation of PAR2 and provides a valuable platform for better understanding key mechanistic roles of PAR2 in human physiology. Results clearly support the development of both antagonists and agonists of human PAR2 as potential disease modifying therapeutic agents.
par genes in Mycobacterium bovis and Mycobacterium smegmatis are arranged in an operon transcribed from "SigGC" promoters

Directory of Open Access Journals (Sweden)

Casart Yveth

2008-03-01

Full Text Available Abstract Background The ParA/Soj and ParB/Spo0J proteins, and the cis-acting parS site, participate actively in chromosome segregation and cell cycle progression. Genes homologous to parA and parB, and two putative parS copies, have been identified in the Mycobacterium bovis BCG and Mycobacterium smegmatis chromosomes. As in Mycobacterium tuberculosis, the parA and parB genes in these two non-pathogenic mycobacteria are located near the chromosomal origin of replication. The present work focused on the determination of the transcriptional organisation of the ~6 Kb orf60K-parB region of M. bovis BCG and M. smegmatis by primer extension, transcriptional fusions to the green fluorescence protein (GFP and quantitative RT-PCR. Results The parAB genes were arranged in an operon. However, we also found promoters upstream of each one of these genes. Seven putative promoter sequences were identified in the orf60K-parB region of M. bovis BCG, whilst four were identified in the homologous region of M. smegmatis, one upstream of each open reading frame (ORF. Real-time PCR assays showed that in M. smegmatis, mRNA-parA and mRNA-parB levels decreased between the exponential and stationary phases. In M. bovis BCG, mRNA-parA levels also decreased between the exponential and stationary phases. However, parB expression was higher than parA expression and remained almost unchanged along the growth curve. Conclusion The majority of the proposed promoter regions had features characteristic of Mycobacterium promoters previously denoted as Group D. The -10 hexamer of a strong E. coli σ70-like promoter, located upstream of gidB of M. bovis BCG, overlapped with a putative parS sequence, suggesting that the transcription from this promoter might be regulated by the binding of ParB to parS.
Par-4-mediated recruitment of Amida to the actin cytoskeleton leads to the induction of apoptosis

International Nuclear Information System (INIS)

Boosen, Meike; Vetterkind, Susanne; Koplin, Ansgar; Illenberger, Susanne; Preuss, Ute

2005-01-01

Par-4 (prostate apoptosis response-4) sensitizes cells to apoptotic stimuli, but the exact mechanisms are still poorly understood. Using Par-4 as bait in a yeast two-hybrid screen, we identified Amida as a novel interaction partner, a ubiquitously expressed protein which has been suggested to be involved in apoptotic processes. Complex formation of Par-4 and Amida occurs in vitro and in vivo and is mediated via the C-termini of both proteins, involving the leucine zipper of Par-4. Amida resides mainly in the nucleus but displays nucleo-cytoplasmic shuttling in heterokaryons. Upon coexpression with Par-4 in REF52.2 cells, Amida translocates to the cytoplasm and is recruited to actin filaments by Par-4, resulting in enhanced induction of apoptosis. The synergistic effect of Amida/Par-4 complexes on the induction of apoptosis is abrogated when either Amida/Par-4 complex formation or association of these complexes with the actin cytoskeleton is impaired, indicating that the Par-4-mediated relocation of Amida to the actin cytoskeleton is crucial for the pro-apoptotic function of Par-4/Amida complexes in REF52.2 cells. The latter results in enhanced phosphorylation of the regulatory light chain of myosin II (MLC) as has previously been shown for Par-4-mediated recruitment of DAP-like kinase (Dlk), suggesting that the recruitment of nuclear proteins involved in the regulation of apoptotic processes to the actin filament system by Par-4 represents a potent mechanism how Par-4 can trigger apoptosis
Prognostic value of suPAR and hs-CRP on cardiovascular disease

DEFF Research Database (Denmark)

Diederichsen, Marie Zöga; Diederichsen, Søren Zöga; Mickley, Hans

2018-01-01

Background and aims: Studies have shown that soluble urokinase Plasminogen Activator Receptor (suPAR) and CRP (both inflammatory markers) and coronary artery calcification (CAC) are independent risk predictors for cardiovascular (CV) disease. The aim of this study is to assess whether suPAR and CRP...... have an increased predictive prognostic value beyond the traditional CV risk factors and the CAC score. Methods: A population sample of 1179 subjects, free of CV disease was included. The subjects underwent traditional CV risk evaluation, CAC assessment and blood sampling for suPAR and CRP. CV events...
mTORC2 activation is regulated by the urokinase receptor (uPAR) in bladder cancer.

Science.gov (United States)

Hau, Andrew M; Leivo, Mariah Z; Gilder, Andrew S; Hu, Jing-Jing; Gonias, Steven L; Hansel, Donna E

2017-01-01

Mammalian target of rapamycin complex 2 (mTORC2) has been identified as a major regulator of bladder cancer cell migration and invasion. Upstream pathways that mediate mTORC2 activation remain poorly defined. Urokinase-type plasminogen activator receptor (uPAR) is a GPI-anchored membrane protein and known activator of cell-signaling. We identified increased uPAR expression in 94% of invasive human bladder cancers and in 54-71% of non-invasive bladder cancers, depending on grade. Normal urothelium was uPAR-immunonegative. Analysis of publicly available datasets identified uPAR gene amplification or mRNA upregulation in a subset of bladder cancer patients with reduced overall survival. Using biochemical approaches, we showed that uPAR activates mTORC2 in bladder cancer cells. Highly invasive bladder cancer cell lines, including T24, J82 and UM-UC-3 cells, showed increased uPAR mRNA expression and protein levels compared with the less aggressive cell lines, UROtsa and RT4. uPAR gene-silencing significantly reduced phosphorylation of Serine-473 in Akt, an mTORC2 target. uPAR gene-silencing also reduced bladder cancer cell migration and Matrigel invasion. S473 phosphorylation was observed by immunohistochemistry in human bladder cancers only when the tumors expressed high levels of uPAR. S473 phosphorylation was not controlled by uPAR in bladder cancer cell lines that are PTEN-negative; however, this result probably did not reflect altered mTORC2 regulation. Instead, PTEN deficiency de-repressed alternative kinases that phosphorylate S473. Our results suggest that uPAR and mTORC2 are components of a single cell-signaling pathway. Targeting uPAR or mTORC2 may be beneficial in patients with bladder cancer. Copyright Â© 2016. Published by Elsevier Inc.
Réduction du risque d'infection par le VIH au Botswana - essais ...

International Development Research Centre (IDRC) Digital Library (Canada)

Au Botswana, ce sont les jeunes femmes qui sont le plus touchées par les nouvelles infections par le VIH. Le présent projet a pour but de réduire le nombre de nouveaux cas d'infection par le VIH, en particulier chez les femmes de 15 à 29 ans. Bien que l'on recense des cas de VIH/sida dans la plupart des régions du ...
Heat exchanges during the re-flooding of a water reactor core - within the framework of the 'reference accident'; Echanges thermiques lors du renoyage d'un coeur de reacteur a eau - dans le cadre de 'l'accident de reference'

Energy Technology Data Exchange (ETDEWEB)

Andreoni, Daniel

1975-11-28

After a brief presentation of reported studies made in different countries and regarding the so-called 'reference accident', this research thesis reports the study of reactor re-flooding when the reactor is completely dried and heating elements have reached a temperature between 300 and 900 C, with a constant water flow rate entering the test section, with a constant dissipated electrical power, and by using very simple geometries. After a first part addressing the experimental study, the author reports the development of conduction calculation codes used to compute the flow extracted by the two-phase flow, present the thermal-hydraulic code used to compute local values and to study the correlation of the upstream area exchange coefficient. The author finally reports an analysis of the different existing models and the study of a re-flooding model [French] La presente etude est consacree a l'un des aspects de la surete des reacteurs a eau sous pression, et plus precisement a l'accident tres important qui consiste en une perte de fluide caloporteur (Loss of Coolant Accident - 'LOCA'). Le but de l'etude est de fournir des renseignements necessaires a l'interpretation des experiences effectuees sur des grappes, de donner une correlation de coefficient d'echange dans la zone aval, et de donner aussi un modele de progression du front de trempe pour les analyses de surete. Une etude bibliographique preliminaire nous a permis de faire le point sur les experiences entreprises concernant le refroidissement de secours. Ensuite, les chapitres suivants seront decrits: 1) Le chapitre II, consacre a l'etude experimentale (boucle, sections d'essais, resultats globaux). 2) Le chapitre III ou seront presentes les codes de calcul de conduction, necessaires au calcul du flux extrait par le melange diphasique, le code de thermohydraulique necessaire au calcul des grandeurs locales et l'etude de la correlation du coefficient d'echange de la zone aval. 3) Enfin le chapitre IV ou, apres
Production of nuclear graphite in France; Production de graphite nucleaire en France

Energy Technology Data Exchange (ETDEWEB)

Legendre, P; Mondet, L [Societe Pechiney, 74 - Chedde (France); Arragon, Ph; Cornuault, P; Gueron, J; Hering, H [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1955-07-01

The graphite intended for the construction of the reactors is obtained by the usual process: confection of a cake from coke of oil and tar, cooked (in a electric oven) then the product of cook is graphitized, also by electric heating. The use of the air transportation and the control of conditions cooking and graphitization have permitted to increase the nuclear graphite production as well as to better control their physical and mechanical properties and to reduce to the minimum the unwanted stains. (M.B.) [French] Le graphite destine a la construction des reacteurs est obtenu par le procede usuel: confection d'une pate a partir de coke de petrole et de brai, cuisson de cette pate (au four electrique) puis graphitation du produit cuit, egalement par chauffage electrique. L'usage du transport pneumatique et le controle des conditions cuisson et de graphitation ont permit d'augmenter la production de graphite nucleaire ainsi que de mieux controler ses proprietes physiques et mecaniques et de reduire au minimum les souillures accidentelles. (M.B.)
Protection of uranium by electrodeposition of nickel and diffusion; Protection de l'uranium par nickelage electrolytique et diffusion

Energy Technology Data Exchange (ETDEWEB)

Chauvin, G; Coriou, H; Hure, J [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

1959-07-01

diffusion, that which is richest in nickel UNi{sub 5}, is the hardest and most brittle. This brittleness results in the systematic appearance of fractures at the Ni-UNi{sub 5} interface; all the diffusion layers remain fixed to the uranium. (author) [French] Ce travail s'integre dans le cadre tres general du probleme de gainage de l'uranium dans les reacteurs nucleaires. En effet il convient notamment: - D'assurer une protection du combustible (uranium) contre la corrosion par le refrigerant (eau lourde, CO, etc.) dans le cas d'une rupture de gaine (Al, Zr, etc.); - D'eviter la diffusion prohibitive U-Al (cas d'une gaine en aluminium) par l'emploi d'une couche intermediaire d'un metal dont la cinetique de diffusion avec l'uranium soit, dans les memes conditions, considerablement plus faible que celle de l'aluminium. De la presente etude, basee sur l'utilisation eventuelle du nickel comme couche intermediaire, on peut degager les principaux points suivants: 1) Apres lui avoir fait subir un traitement de surface chimique determine, on peut realiser sur l'uranium des depots electrolytiques de nickel d'une adherence telle que, apres un recuit sans l'application d'aucune pression, ces depots donnent lieu a une bonne diffusion intermetallique U-Ni. Tout en restant tres inferieure a celle du systeme U-Al, cette diffusion permet de renforcer la protection, donc d'accroitre la resistance du combustible a la corrosion. 2) Toutes autres conditions egales par ailleurs, l'experience montre que la qualite des zones de diffusion obtenues depend de la nature du bain de nickelage. 3) Les bains classiques de nickelage utilises jusqu'a present dans ce domaine d'etude contiennent 20 a 40 g/l d'acide borique a titre de tampon electrolytique. Il en resulte une contamination extremement elevee des depots de nickel par 400 a 500 ppm de bore. Nous montrons qu'avec au moins un bain exempt de poisons nucleaires, on peut obtenir des zones de diffusion U-Ni tres saines. 4) Apres un recuit de 100 heures
A mechanism for ParB-dependent waves of ParA, a protein related to DNA segregation during cell division in prokaryotes

DEFF Research Database (Denmark)

Hunding, Axel; Gerdes, Kenn; Charbon, Gitte Ebersbach

2003-01-01

in an autocatalytic process. We discuss this mechanism in relation to recent models for MinDE oscillations in E.coli and to microtubule degradation in mitosis. The study points to an ancestral role for the presented pattern types in generating bipolarity in prokaryotes and eukaryotes.......Prokaryotic plasmids encode partitioning (par) loci involved in segregation of DNA to daughter cells at cell division. A functional fusion protein consisting of Walker-type ParA ATPase and green fluorescent protein (Gfp) oscillates back and forth within nucleoid regions with a wave period of about...
[Ambroise Paré in French literature].

Science.gov (United States)

Dumaitre, P

1995-01-01

The 16th century by its passionate side has been the favourite one of authors of historical novels in which among the heroes of "cloak and dagger stories" appears sometime Ambroise Paré. Alexandre Dumas (the father) has shown him at the court of Charles IX in La Reine Margot (1845) where he does not however play a great role. On the contrary, Balzac in Le Martyr calviniste (1842) has given him a capital part close to the dying François II, whom he intended to trepanize but had to give up this idea as a consequence of the opposition of the queen-mother Catherine de Médicis. In the present century, Robert Merle in Paris ma bonne ville (Fortune de France, 3, 1980) shows Paré at the time of the Saint Barthélemy.
Les dispensées par fantaisie en éducation physique et sportive ...

African Journals Online (AJOL)

Cette étude vise à comprendre les raisons avancées par les élèves dispensés par fantaisie des cours d'EPS, pour justifier leur attitude et principalement leur forfait. Une enquête par questionnaire écrit a été menée dans 13 établissements publics de la ville de Porto-Novo au Bénin. Au total, 203 élèves parmi les 771 élèves ...

Complexation de l'aluminium par des hétéropolyanions lacunaires ...

African Journals Online (AJOL)

L'objectif visé par cette étude est la dépollution des eaux à partir de la complexation d'un métal toxique, l'aluminium en solution, par des hétéropolyanions lacunaires (HPA) de type Dawson. Les complexes formés sont récupérés par membrane liquide émulsionnée (MEL).Les résultats de la complex1ation de l'aluminium ...
Study of the dynamic behaviour of the reactor Rapsodie; Etude du comportement dynamique de la pile rapsodie

Energy Technology Data Exchange (ETDEWEB)

Abdon, R; Chaigne, M [Commissariat a l' Energie Atomique, Cadarache (France). Centre d' Etudes Nucleaires

1964-07-01

. The investigation of the control, carried out on analog computer, served to determine the different possible means of starting and changing the conditions of the reactor as well as its automatic control. The calculations were examined in the totality by the construction of a training simulator composed of a board similar to the control board of the reactor, all of whose commands (reactivity and flows) work on an analogue computer which resolves in the real time the dynamic equations of the reactor and which reproduces simultaneously all the parameters representing the state of the installation (power, period, temperatures, etc. ) in the case of various incidents as well as under normal conditions of functioning. (authors) [French] On sait que le developpement des reacteurs surgenerateurs a neutrons rapides pose des problemes nouveaux d'une part dans les domaines mecanique et thermique et d'autre part en ce qui concerne leur comportement dynamique et leur surete. La pile RAPSODIE a ete l'objet de tres nombreuses etudes dynamiques effectuees sur machines analogiques et digitales, pour deux versions du combustible (metal et oxyde). Apres elaboration des modeles mathematiques representatifs de l'ensemble de l'installation (bloc pile et circuit de refroidissement) tant du point de vue neutronique que du point de vue thermodynamique, on a mis au point les schemas analogiques et les codes digitaux utilisables pour mener a bien les simulations d'incidents, de conduite et de stabilite du reacteur. On s'est attache, par rapport aux methodes habituelles a obtenir une precision plus grande, par un decoupage en zones plus fines, par l'emploi de formulations plus representatives du systeme reel, voire solubles analytiquement. Les etudes d'incidents ont ete effectuees par voie analogique pour l'ensemble de l'installation et par voie digitale pour l'etude du bloc pile seul ou de l'installation fonctionnant avec un seul circuit thermique. Un programme complementaire special - qui, a
Removal of focal segmental glomerulosclerosis (FSGS) factor suPAR using CytoSorb.

Science.gov (United States)

Schenk, Heiko; Müller-Deile, Janina; Schmitt, Roland; Bräsen, Jan Hinrich; Haller, Hermann; Schiffer, Mario

2017-12-01

Treatment of primary focal segmental glomerulosclerosis (FSGS) and its recurrence after kidney transplantation associated with rapid deterioration of kidney function remains to be challenging despite advances in immunosuppressive therapy. The presence of circulating factors has been postulated to be a pivotal player in the pathogenesis of FSGS, although suPAR and CLCF-1 have been identified as the most promising causative factors. The potential therapeutic effect of suPAR elimination in an FSGS patient using CytoSorb, a hemoadsorption device that gained attention in the cytokine elimination in septic patients, was studied. Efficiency of total plasma exchange to remove suPAR was determined. CytoSorb hemoadsorption caused a 27.33% reduction of the suPAR level in a single treatment, whereas total plasma exchange showed a suPAR level reduction of 25.12% (n = 3; 95% confidence interval, 0.2777-0.8090; P < 0.01), which may indicate therapeutic potential in the treatment of primary FSGS and its recurrence in a kidney transplant. © 2017 Wiley Periodicals, Inc.
Thrombin induces rapid PAR1-mediated non-classical FGF1 release

International Nuclear Information System (INIS)

Duarte, Maria; Kolev, Vihren; Soldi, Raffaella; Kirov, Alexander; Graziani, Irene; Oliveira, Silvia Marta; Kacer, Doreen; Friesel, Robert; Maciag, Thomas; Prudovsky, Igor

2006-01-01

Thrombin induces cell proliferation and migration during vascular injury. We report that thrombin rapidly stimulated expression and release of the pro-angiogenic polypeptide fibroblast growth factor 1 (FGF1). Thrombin failed to induce FGF1 release from protease-activated receptor 1 (PAR1) null fibroblasts, indicating that this effect was dependent on PAR1. Similarly to thrombin, FGF1 expression and release were induced by TRAP, a specific oligopeptide agonist of PAR1. These results identify a novel aspect of the crosstalk between FGF and thrombin signaling pathways which both play important roles in tissue repair and angiogenesis
Apparatus of irradiation of steel test pieces in the Marcoule pile G 1; Dispositifs d'irradiation d'eprouvettes d'acier dans la pile G 1 de Marcoule

Energy Technology Data Exchange (ETDEWEB)

Marinot, R.; Wallet, Ph. [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

1960-07-01

Test pieces of steel were irradiated in the reactor G1 at Marcoule, in convectors replacing fuel elements, and in vertical channels in furnace-heated containers. The apparatus designed for this irradiation is described: containers, converter-rods, suspension fixtures and clamps, temperature measurement devices, lead castles and unloading set-ups. (author) [French] Des eprouvettes d'acier ont ete irradiees dans le reacteur G1 de Marcoule dans des convertisseurs mis a la place d'elements combustibles, et dans des canaux verticaux, en conteneurs chauffes par four. Nous decrivons l'appareillage etudie pour cette irradiation: conteneurs, barreaux-convertisseurs, dispositifs de suspension et d'amarrage, dispositifs de regulation et de mesure de temperature, chateaux de plomb et montages de defournement. (auteur)
Examining relational empowerment for elementary school students in a yPAR program.

Science.gov (United States)

Langhout, Regina Day; Collins, Charles; Ellison, Erin Rose

2014-06-01

This paper joins relational empowerment, youth empowerment, and Bridging Multiple Worlds frameworks to examine forms of relational empowerment for children in two intermediary institutions-school and a youth participatory action research after-school program (yPAR ASP). Participants were twelve children, most of whom were Latina/o and from im/migrant families, enrolled in a yPAR ASP for 2 years. A mixed-method approach was utilized; we analyzed children's interviews, self-defined goals, and their social networks to examine their experiences of relational empowerment. We conclude that children experienced each of the five relational empowerment factors-collaborative competence, bridging social divisions, facilitating others' empowerment, mobilizing networks, and passing on a legacy-in the yPAR ASP setting, and some factors in school. These experiences, however, were more pronounced in the yPAR ASP setting. Additionally, social network analyses revealed that a small but meaningful percentage of actors bridged worlds, especially home and family, but by year 2, also school and the yPAR ASP. Finally, most helpers for school-based goals came from school, but a sizable number came from family, friends, and home worlds, and by year 2, also came from the yPAR ASP. Implications range from theoretical to methodological development, including the use of social network analysis as a tool to descriptively examine relational power in context.
Elevated soluble urokinase plasminogen activator receptor (suPAR) predicts mortality in Staphylococcus aureus bacteremia

DEFF Research Database (Denmark)

Mölkänen, T; Ruotsalainen, E; Thorball, C W

2011-01-01

The soluble form of urokinase-type plasminogen activator receptor (suPAR) is a new inflammatory marker. High suPAR levels have been shown to associate with mortality in cancer and in chronic infections like HIV and tuberculosis, but reports on the role of suPAR in acute bacteremic infections...... are scarce. To elucidate the role of suPAR in a common bacteremic infection, the serum suPAR levels in 59 patients with Staphylococcus aureus bacteremia (SAB) were measured using the suPARnostic ELISA assay and associations to 1-month mortality and with deep infection focus were analyzed. On day three, after...... the first positive blood culture for S. aureus, suPAR levels were higher in 19 fatalities (median 12.3; range 5.7-64.6 ng/mL) than in 40 survivors (median 8.4; range 3.7-17.6 ng/mL, p = 0.002). This difference persisted for 10 days. The presence of deep infection focus was not associated with elevated su...
The polarity protein Par6 is coupled to the microtubule network during molluscan early embryogenesis

Energy Technology Data Exchange (ETDEWEB)

Homma, Taihei [Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Shimizu, Miho [Kuroda Chiromorphology Team, ERATO-SORST, JST, Komaba, Meguro-ku, Tokyo 153-8902 (Japan); Kuroda, Reiko, E-mail: ckuroda@mail.ecc.u-tokyo.ac.jp [Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Kuroda Chiromorphology Team, ERATO-SORST, JST, Komaba, Meguro-ku, Tokyo 153-8902 (Japan); Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902 (Japan)

2011-01-07

Research highlights: {yields} The cDNAs encoding Par6 and aPKC homologues were cloned from the snail Lymnaea stagnalis. {yields} L. stagnalis Par6 directly interacts with tubulin and microtubules and localizes to the microtubule cytoskeleton during the early embryogenesis. {yields} Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of body handedness. -- Abstract: Cell polarity, which directs the orientation of asymmetric cell division and segregation of fate determinants, is a fundamental feature of development and differentiation. Regulators of polarity have been extensively studied, and the critical importance of the Par (partitioning-defective) complex as the polarity machinery is now recognized in a wide range of eukaryotic systems. The Par polarity module is evolutionarily conserved, but its mechanism and cooperating factors vary among different systems. Here we describe the cloning and characterization of a pond snail Lymnaea stagnalis homologue of partitioning-defective 6 (Lspar6). The protein product LsPar6 shows high affinity for microtubules and localizes to the mitotic apparatus during embryonic cell division. In vitro assays revealed direct binding of LsPar6 to tubulin and microtubules, which is the first evidence of the direct interaction between the two proteins. The interaction is mediated by two distinct regions of LsPar6 both located in the N-terminal half. Atypical PKC, a functional partner of Par6, was also found to localize to the mitotic spindle. These results suggest that the L. stagnalis Par complex employs the microtubule network in cell polarity processes during the early embryogenesis. Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of handedness.
The polarity protein Par6 is coupled to the microtubule network during molluscan early embryogenesis

International Nuclear Information System (INIS)

Homma, Taihei; Shimizu, Miho; Kuroda, Reiko

2011-01-01

Research highlights: → The cDNAs encoding Par6 and aPKC homologues were cloned from the snail Lymnaea stagnalis. → L. stagnalis Par6 directly interacts with tubulin and microtubules and localizes to the microtubule cytoskeleton during the early embryogenesis. → Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of body handedness. -- Abstract: Cell polarity, which directs the orientation of asymmetric cell division and segregation of fate determinants, is a fundamental feature of development and differentiation. Regulators of polarity have been extensively studied, and the critical importance of the Par (partitioning-defective) complex as the polarity machinery is now recognized in a wide range of eukaryotic systems. The Par polarity module is evolutionarily conserved, but its mechanism and cooperating factors vary among different systems. Here we describe the cloning and characterization of a pond snail Lymnaea stagnalis homologue of partitioning-defective 6 (Lspar6). The protein product LsPar6 shows high affinity for microtubules and localizes to the mitotic apparatus during embryonic cell division. In vitro assays revealed direct binding of LsPar6 to tubulin and microtubules, which is the first evidence of the direct interaction between the two proteins. The interaction is mediated by two distinct regions of LsPar6 both located in the N-terminal half. Atypical PKC, a functional partner of Par6, was also found to localize to the mitotic spindle. These results suggest that the L. stagnalis Par complex employs the microtubule network in cell polarity processes during the early embryogenesis. Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of handedness.
A critical summary of microscopic fast-neutron interactions with reactor structural, fissile and fertile materials; Apercu critique des interactions microscopiques des neutrons rapides avec les materiaux de construction et les matieres fissiles et fertiles utilisees dans les reacteurs; Kriticheskij obzor mikroskopicheskog o vzaimodejstviya bystrykh nejtronov s konstruktsionnymi, rasshcheplyayushchimis ya i vosproizvodyashchim i reaktornymi materialami; Resumen critico de las interacciones microscopicas de los neutrones rapidos con los materiales estructurales fisionables y fertiles utilizados en los reactores

Energy Technology Data Exchange (ETDEWEB)

Smith, A B [Argonne National Laboratory, Argonne, IL (United States)

1962-03-15

Prevailing knowledge of fast-neutron-induced reactions utilized in the nuclear design of reactor systems is reviewed. Principal emphasis is placed upon microscopic experimental methods, results and precisions. Fast-neutron scattering is considered in detail, including the results of experimental determinations of scattering from oxygen, iron, zirconium, niobium, tungsten, thorium and uranium. Representative results of experimental studies of fast-neutron capture and fast-neutron-induced fission are given. The measurements discussed not only provide results of considerable applied usefulness but axe also examples of the application of advanced experimental nuclear techniques. Areas of limited, conflicting or non-existent experimental information are outlined. A prognosis of future knowledge of fast-neutron reactions is made, with emphasis on the fulfillment of reactor requirements for basic nuclear data. (author) [French] L'auteur fait le point des connaissances sur les reactions provoquees par les neutrons rapides sur lesquelles on tend a fonder les projets de reacteurs. Il met en relief les methodes, les resultats et la precision de mesures experimentales a l'echelle microscopique. Il etudie en detail la diffusion des neutrons rapides, et donne les resultats de mesures experimentales de diffusion dans l'oxygene, le fer, le zirconium, le niobium, le tungstene, le thorium et l'uranium. Il donne les resultats les plus significatifs d'etudes experimentales sur la capture des neutrons rapides et sur la fission provoquee par des neutrons rapides. Les mesures etudiees, non seulement fournissent des renseignements d'une utilite pratique considerable, mais aussi constituent des exemples de l'application de techniques experimentales nucleaires a la pointe du progres. L'auteur indique les domaines ou les donnees experimentales sont limitees, contradictoires ou inexistantes. Il se livre a des pronostics sur le developpement des connaissances experimentales en matiere de
MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.

Directory of Open Access Journals (Sweden)

Laura P Bernard

Full Text Available The Par1 kinases, also known as microtubule affinity-regulating kinases (MARKs, are important for the establishment of cell polarity from worms to mammals. Dysregulation of these kinases has been implicated in autism, Alzheimer's disease and cancer. Despite their important function in health and disease, it has been unclear how the activity of MARK/Par1 is regulated by signals from cell surface receptors. Here we show that MARK/Par1 is activated downstream of NMDA receptors in primary hippocampal neurons. Further, we show that this activation is dependent on protein kinase A (PKA, through the phosphorylation of Ser431 of Par4/LKB1, the major upstream kinase of MARK/Par1. Together, our data reveal a novel mechanism by which MARK/Par1 is activated at the neuronal synapse.
Tumour Microenvironments Induce Expression of Urokinase Plasminogen Activator Receptor (uPAR) and Concomitant Activation of Gelatinolytic Enzymes

Science.gov (United States)

Magnussen, Synnøve; Hadler-Olsen, Elin; Latysheva, Nadezhda; Pirila, Emma; Steigen, Sonja E.; Hanes, Robert; Salo, Tuula; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Svineng, Gunbjørg

2014-01-01

Background The urokinase plasminogen activator receptor (uPAR) is associated with poor prognosis in oral squamous cell carcinoma (OSCC), and increased expression of uPAR is often found at the invasive tumour front. The aim of the current study was to elucidate the role of uPAR in invasion and metastasis of OSCC, and the effects of various tumour microenvironments in these processes. Furthermore, we wanted to study whether the cells’ expression level of uPAR affected the activity of gelatinolytic enzymes. Methods The Plaur gene was both overexpressed and knocked-down in the murine OSCC cell line AT84. Tongue and skin tumours were established in syngeneic mice, and cells were also studied in an ex vivo leiomyoma invasion model. Soluble factors derived from leiomyoma tissue, as well as purified extracellular matrix (ECM) proteins, were assessed for their ability to affect uPAR expression, glycosylation and cleavage. Activity of gelatinolytic enzymes in the tissues were assessed by in situ zymography. Results We found that increased levels of uPAR did not induce tumour invasion or metastasis. However, cells expressing low endogenous levels of uPAR in vitro up-regulated uPAR expression both in tongue, skin and leiomyoma tissue. Various ECM proteins had no effect on uPAR expression, while soluble factors originating from the leiomyoma tissue increased both the expression and glycosylation of uPAR, and possibly also affected the proteolytic processing of uPAR. Tumours with high levels of uPAR, as well as cells invading leiomyoma tissue with up-regulated uPAR expression, all displayed enhanced activity of gelatinolytic enzymes. Conclusions Although high levels of uPAR are not sufficient to induce invasion and metastasis, the activity of gelatinolytic enzymes was increased. Furthermore, several tumour microenvironments have the capacity to induce up-regulation of uPAR expression, and soluble factors in the tumour microenvironment may have an important role in the
Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR and concomitant activation of gelatinolytic enzymes.

Directory of Open Access Journals (Sweden)

Synnøve Magnussen

Full Text Available The urokinase plasminogen activator receptor (uPAR is associated with poor prognosis in oral squamous cell carcinoma (OSCC, and increased expression of uPAR is often found at the invasive tumour front. The aim of the current study was to elucidate the role of uPAR in invasion and metastasis of OSCC, and the effects of various tumour microenvironments in these processes. Furthermore, we wanted to study whether the cells' expression level of uPAR affected the activity of gelatinolytic enzymes.The Plaur gene was both overexpressed and knocked-down in the murine OSCC cell line AT84. Tongue and skin tumours were established in syngeneic mice, and cells were also studied in an ex vivo leiomyoma invasion model. Soluble factors derived from leiomyoma tissue, as well as purified extracellular matrix (ECM proteins, were assessed for their ability to affect uPAR expression, glycosylation and cleavage. Activity of gelatinolytic enzymes in the tissues were assessed by in situ zymography.We found that increased levels of uPAR did not induce tumour invasion or metastasis. However, cells expressing low endogenous levels of uPAR in vitro up-regulated uPAR expression both in tongue, skin and leiomyoma tissue. Various ECM proteins had no effect on uPAR expression, while soluble factors originating from the leiomyoma tissue increased both the expression and glycosylation of uPAR, and possibly also affected the proteolytic processing of uPAR. Tumours with high levels of uPAR, as well as cells invading leiomyoma tissue with up-regulated uPAR expression, all displayed enhanced activity of gelatinolytic enzymes.Although high levels of uPAR are not sufficient to induce invasion and metastasis, the activity of gelatinolytic enzymes was increased. Furthermore, several tumour microenvironments have the capacity to induce up-regulation of uPAR expression, and soluble factors in the tumour microenvironment may have an important role in the regulation of posttranslational
Operating Experience with the VERA Zero-Energy Fast Reactor; Fonctionnement du Reacteur VERA a Neutrons Rapides, de Puissance Zero; Opyt ehkspluatatsii reaktora VERA na bystrykh nejtronakh nulevoj moshchnosti; Experiencia Adquirida con el Reactor Rapido VERA de Potencia Nula

Energy Technology Data Exchange (ETDEWEB)

Weale, J. W.; McTaggart, M. H.; Goodfellow, H.; Paterson, W. J. [Atomic Weapons Research Establishment, Aldermaston (United Kingdom)

1964-02-15

The design of a two-halves zero-energy fast reactor is briefly described, particular emphasis being placed on those features which determine the practicability and precision of reactor physics measurements. The advantages and disadvantages of the design are discussed with reference to the two years' operating experience of the reactor. The following topics are dealt with: the experimental convenience of the lay-out and of the two halves design; the size and precision of the fuel pieces and the accuracy of location of the fuel elements; the effects of edge irregularities and heterogeneity of structure on the accuracy with which the critical mass of an 'ideal' equivalent assembly is determined; reproducibility of the critical condition after dismantling the assembly, or separating the two halves; variation of reactivity with separation of the halves, including effects of asymmetric loading; sensitivity of various counters, neutron source strength, use of an accelerator neutron source; speed of response of safety circuits and consequent restrictions on rate of assembly of the two halves; additional precautions necessary in using plutonium fuel; and notes on the accuracy of measurement of reactivity and on the practical limitations affecting various other reactor physics measurements. (author) [French] Les auteurs decrivent brievement ce modele de reacteur a neutrons rapides et de puissance zero construit en deux moities, en insistant particulierment sur les caracteristiques qui determinent la possibilites de faire des mesures relatives a la physique des reacteurs et la precision de ces mesures. Ils exposent les avantages et les inconvenients de ce modele compte tenu de l'experience acquise au cours des deux annees de fonctionnement du reacteur. Ils traitent les sujets suivants: interet pratique, au point de vue experimental, du plan de ce reacteur et de sa constitution en deux moities; dimension et precision des pieces de combustible et exactitude de l'emplacement des
Influencia de los parámetros de proceso, en el comportamiento del parámetro vibración absoluta en turbinas de vapor.

Directory of Open Access Journals (Sweden)

F. de la Torre Silva

2008-01-01

Full Text Available Este trabajo muestra el estudio realizado en turbinas de vapor de pequeña capacidad de generación de las centrales termoeléctricas cubanas, relacionadas con la influencia estadística entre parámetros de proceso de la turbina, respecto al parámetro vibración absoluta, medidos en las chumaceras de la turbina. Se utilizan las bases de datos de los sistemas de monitoreado on-line de la turbina. Se exponen las relaciones existentes entre los principales parámetros seleccionados para este estudio.This work show the study in small steam turbine capacity of generation in cubans thermoelectric power station to relative with statistical influence between steam process parameters regarding absolute vibration parameter, in the steam housing measurements. Themselves use database as steam on-line monitoring systems. Expose the existing relation between the principal selection parameters for this study.
Contamination potentielle des aliments par des ...

African Journals Online (AJOL)

SARA Computers

la notion de la pollution et de l'exposition aux PCBs, lorsque 77% n'ont pas conscience de cette situation de risque ... 2018). Quoique la contamination par les. PCBs soit de faible niveau, elle est ...... Université Paris-Est, Paris, France ; 183.
Techniques d'inspection par ondes guidees ultrasonores d'assemblages brases dans des reacteurs aeronautiques =

Science.gov (United States)

Comot, Pierre

L'industrie aeronautique, cherche a etudier la possibilite d'utiliser de maniere structurelle des joints brases, dans une optique de reduction de poids et de cout. Le developpement d'une methode d'evaluation rapide, fiable et peu couteuse pour evaluer l'integrite structurelle des joints apparait donc indispensable. La resistance mecanique d'un joint brase dependant principalement de la quantite de phase fragile dans sa microstructure. Les ondes guidees ultrasonores permettent de detecter ce type de phase lorsqu'elles sont couplees a une mesure spatio-temporelle. De plus la nature de ce type d'ondes permet l'inspection de joints ayant des formes complexes. Ce memoire se concentre donc sur le developpement d'une technique basee sur l'utilisation d'ondes guidees ultrasonores pour l'inspection de joints brases a recouvrement d'Inconel 625 avec comme metal d'apport du BNi-2. Dans un premiers temps un modele elements finis du joint a ete utilise pour simuler la propagation des ultrasons et optimiser les parametres d'inspection, la simulation a permis egalement de demontrer la faisabilite de la technique pour la detection de la quantite de phase fragile dans ce type de joints. Les parametres optimises sont la forme de signal d'excitation, sa frequence centrale et la direction d'excitation. Les simulations ont montre que l'energie de l'onde ultrasonore transmise a travers le joint aussi bien que celle reflechie, toutes deux extraites des courbes de dispersion, etaient proportionnelles a la quantite de phase fragile presente dans le joint et donc cette methode permet d'identifier la presence ou non d'une phase fragile dans ce type de joint. Ensuite des experimentations ont ete menees sur trois echantillons typiques presentant differentes quantites de phase fragile dans le joint, pour obtenir ce type d'echantillons differents temps de brasage ont ete utilises (1, 60 et 180 min). Pour cela un banc d'essai automatise a ete developpe permettant d'effectuer une analyse similaire a celle utilisee en simulation. Les parametres experimentaux ayant ete choisis en accord avec l'optimisation effectuee lors des simulations et apres une premiere optimisation du procede experimental. Finalement les resultats experimentaux confirment les resultats obtenus en simulation, et demontrent le potentiel de la methode developpee.
Fuel material neutron crystallography texture and structure determinations (1960); Etudes sur l'evolution des structures cristallines de l'uranium par neutrocristallographie (1960)

Energy Technology Data Exchange (ETDEWEB)

Laniesse, J; Englander, M; Meriel, P [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

1960-07-01

{beta} {yields} {alpha} transformation at 333 deg. K of a bulk U alloy containing 1000 ppm chromium. (author) [French] La methode utilisee permet d'obtenir d'une maniere plus rapide et plus statistique que par difraction de rayons X des informations sur la texture d'agregats polycristallins d'uranium-metal et sur les cours de l'evolution de leurs structures crystallines pendant leurs transformations allotropiques. Elle emploie un faisceau neutronique sortant du reacteur EL3 au CEN Saclay, monochromatise a {lambda} = 1,143 A {+-} 0,030 Angstrom; l'axe de ce faisceau rigoureusement collimate, est dirige perpendiculairement a l'axe de fibre de l'echantillon de forme cylindrique et de dimensions optimales. Les neutrons diffuses sont recus dans un compteur BF3 qui peut decrire un cercle centre sur l'echantillon (R = 1,30 m), dans un plan horizontal passant par l'axe du faisceau; de plus, le dispositif de fixation de l'echantillon permet la rotation de celui-ci autour de son axe longitudinal. Le spectre de reference des raies de diffraction neutronique de la phase {alpha} de l'uranium pur est ainsi obtenu a la temperature ordinaire, en utilisant un echantillon pour lequel il est certain qu'il n'existe aucune texture parasite ou residuaire. Il en est de meme pour la phase {beta} d'une solution solide metastable d'uranium contenant la concentration nominale d'impuretes metalliques telles que le Cr ou le Si. Ces deux spectres sont compares aux spectres theoriques ainsi qu'aux spectres de diffraction roentgenographiques. En choisissant ensuite convenablement un certain nombre de ces raies de diffraction, les evaluations d'orientations predominantes eventuelles peuvent etre suivies qualitativement et semi-quantitativement, en fonction des differents traitements mecaniques et/ou thermiques subis simultanement ou non par l'echantillon. De meme en enregistrant d'une maniere continue l'intensite d'une raie mixte judicieusement placee par rapport aux raies des spectres {alpha} et {beta
Determination of the Effectiveness of Control Rods in the VVER Reactor Fuel Assemblies; Determination de l'Efficacite des Barres de Reglage dans les Ensembles Combustibles du reacteur VVER; Opredelenie ehffektivnosti reguliruyushchikh sterzhnej v sborkakh reaktora VVEHR; Determinacion de la Eficacia de las Barras de Control en los Conjuntos de Elementos Combustibles del Reactor VVER

Energy Technology Data Exchange (ETDEWEB)

Semenov, V. N.; Lunin, G. L.; Komissarov, L. V.; Kamyshan, A. N.; Halizev, V. I.; Andrianov, G. Ja.; Voznesenskij, V. A.; Kuz' micheva, V. A.; Lebedev, V. I. [Ordena Lenina Institut Atomnoj Energii Im. I.V. Kurchatova, Moskva, SSSR (Russian Federation)

1964-06-15

The paper describes experiments done in homogeneous mock-ups of the fuel assemblies from the VVER Reactor (at one level of enrichment) to determine the effectiveness of absorbing systems comprising shim fuel assemblies or water cavities and of absorbing rods clad in jackets made of differing materials. The paper also gives data on some experiments that have been done in mock-ups of assemblies with differing levels of enrichment. These experiments make it possible to verify the methods used in calculation and to evaluate the prospects of using them for heterogeneous reactors. (author) [French] Le memoire decrit les experiences qui ont ete faites pour determiner l 'efficacite des absorbants contenus dans les barres de compensation, l'effet cavitaire et l 'efficacite des absorbants gaines de materiaux divers, au moyen d'assemblages homogenes de cartouches de combustible du reacteur VVER (reacteur de puissance ralenti et refroidi a l 'eau ayant le meme taux d'enrichissement. On y trouve en outre des donnees sur certaines experiences executees a l 'aide d'assemblages de cartouches de combustible taux d'enrichissement differents. Ces travaux permettent de verifier la methode de calcul et d'evaluer ses possibilites d'application aux reacteurs non homogenes. (author) [Spanish] Se describen en la memoria experimentos para determinar la eficacia de los materiales absorbentes contenidos en las barras de compensacion, el efecto de cavitacion y la eficacia de los materiales absorbentes revestidos de diversos materiales, realizados con ayuda de los conjuntos homogeneos de elementos combustibles del reactor VVER (reactor de potencia moderado y refrigerado por agua) con un solo grado de enriquecimiento. Ademas, se exponen datos sobre los experimentos efectuados con ayuda de conjuntos de grados de enriquecimientos; variados. Tales experimentos permiten verificar el metodo de calculo teorico, utilizad o y evaluar la posibilidad de aplicarlo a los reactores no homogeneos. (author
Accouchement par césarienne et mortalité maternelle du postpartum

OpenAIRE

Deneux-Tharaux , Catherine; Carmona , Elodie; Bouvier-Colle , Marie-Hélène; Bréart , Gérard

2006-01-01

Objectifs Une augmentation continue du taux d'accouchements par césarienne (CS)est observée dans la plupart des pays depuis 20 ans. Cette évolution a suscité l'émergence d'un débat controversé sur les risques et les bénéfices associés à la CS. L'objectif de cette étude était d'estimer le risque de mort maternelle du postpartum lié directement à la CS par comparaison à l'accouchement par voie basse, globalement et en distinguant les CS pre- ou intra- partum . Méthode Etude cas/témoins. Les cas...

Prise en charge des intoxications par envenimation chez les enfants ...

African Journals Online (AJOL)

Les signes cliniques étaient dominés par les douleurs (98%) suivies des hémorragies (73,80%) pour les morsures de serpent, la douleur pour les piqures de scorpion (100%) et les oedèmes pour les piqures d'abeilles (100%). Les cas de morsure de serpent ont été traités par le sérum antivenimeux polyvalent. Conclusion: ...
Initial Operating Experience with the ''NPD'' Reactor; Experience recueillie pendant les premiers mois de fonctionnement du reacteur NPD; Pervyj opyt po ehkspluatatsii reaktora NPD; Experiencia inicial de funcionamiento del reactor NPD

Energy Technology Data Exchange (ETDEWEB)

McConnell, L. G. [Hydro-Electric Power Commission of Ontario, Toronto, Ontario (Canada)

1963-10-15

'y apporter des perfectionnements pendant les periodes d'arret complet. Les resultats obtenus jusqu'a present ont ete positifs; la premiere experience de fonctionnement, qui a dure six semaines, a permis d'obtenir un facteur de puissance de 70%. Les perfectionnements deja apportes ont permis d'augmenter la securite, d'ameliorer les performances et ont montre en meme temps qu*il etait possible de reduire les depenses d'investissement pour les centrales futures. On a, par exemple, modifie les joints d'arbre des pompes du circuit primaire de refroidissement pour obtenir de meilleures performances; les appareils de recuperation de la vapeur, a congelation', ont ete remplaces par des colonnes d'absorption de facon a reduire les pertes de vapeur d'eau lourde; des regulateurs de debit sont installes en certains points pour reduire les pertes d'eau lourde pour le cas ou des joints cederaient. En decembre 1962, deux fuites simultanees dans l'appareil de rechargement en puissance ont entraihe une serie inhabituelle d'incidents; une quantite importante d'eau lourde a haute pression et haute temperature a ete projetee dans l'enceinte du reacteur ou sa purete isotopique a ete legerement alteree. On a redonne a l'eau lourde la purete voulue et le reacteur a pu recommencer a fonctionner a la fin du mois. Touslesdispositift de securite, notamment ceux destines a parer aux fuites d'eau lourde, ont fonctionne correctement pendant l'accident. (author) [Spanish] La primera central nucleoelectrica del Canada, NPD, constituye una instalacion de demostracion, destinada a comprobar el funcionamiento de los reactores alimentados con uranio natural y moderados y refrigerados por agua pesada. Alcanzo su regimen normal de potencia el 28 de junio de 1962. Aunque ha sido disenada como central para la carga basica, en las primeras fases funcionara en parte como central para la carga de cresta, lo que permitira introducir mejoras durante los periodos de paro. Los resultados obtenidos hasta el presente
Possibilities of long duration generation of vapour of iodine 131 in the air for its trapping in French activated carbons; Possibilites de generation de longue duree dans l'air de vapeur d'iode 131 en vue de son piegeage par les charbons actifs francais

Energy Technology Data Exchange (ETDEWEB)

Billard, F.; Chevalier, G.; Pradel, J.

1962-12-17

As previous studies performed on activated carbon showed that it was necessary to possess a long duration iodine generator to determine the scope of application of some advanced theories concerning the trap mechanism of different forms of radio-iodines, the authors present a generator which uses the high temperature oxidation of sodium iodide by an air stream or an oxygen stream. A version of this apparatus using a 5 Curie source is planned to check the operation of a trap of 100.000 m{sup 3}/h with a purification coefficient of 10{sup 4}, and aimed at being mounted on the venting circuit of a nuclear reactor enclosure [French] Les etudes que nous avons effectuees sur les charbons actifs nous ont montre qu'il etait necessaire de posseder un generateur d'iode de longue duree pour preciser le domaine d'application de certaines theories avancees concernant le mecanisme de piegeage des differentes formes de radioiodes. Un generateur utilisant l'oxydation de l'iodure de sodium a chaud par un courant d'air ou d'oxygene est decrit. Une version de cet appareil utilisant une source de 5 curies est prevue pour verifier le bon fonctionnement d'un piege de 100.000 m{sup 3}/h ayant un coefficient d'epuration de 10{sup 4} est destine a etre place sur le circuit de ventilation de l'enceinte d'un reacteur nucleaire. (auteurs)
Experimental study about the regulating effect of Par-4 gene overexpression on the nephroblastoma sensitivity to cisplatin

Directory of Open Access Journals (Sweden)

Hui-Lin Mao

2017-11-01

Full Text Available Objective: To study the regulating effect of Par-4 gene overexpression on the nephroblastoma sensitivity to cisplatin. Methods: Nephroblastoma SK-NEP-1 cells were cultured and divided into four groups, control group were treated with RMPI-1640 without serum or drugs, cisplatin group were treated with serum-free RMPI-1640 containing 5 μg/mL cisplatin, Par-4 group were transfected by Par-4 overexpression plasmids with serum-free RMPI-1640, and cisplatin + Par-4 group were transfected by Par-4 overexpression plasmid with serum-free RMPI-1640 containing 5 μg/mL cisplatin. The cell proliferation activity as well the expression of apoptosis genes, migration genes and invasion genes was measured. Results: 8 h, 16 h and 24 h after different conditions of treatment, the cell proliferation activity of cisplatin group, Par-4 group and cisplatin + Par-4 group were significantly lower than that of control group, and the cell proliferation activity of cisplatin + Par-4 group was significantly lower than that of cisplatin group and Par-4 group; 24 h after different conditions of treatment, Bim, PDCD4, WT1, RGS4, Axin, KAI1, E-cadherin, PPARγ and PTEN mRNA expression in cisplatin group, Par-4 group and cisplatin + Par-4 group were greatly higher than those in control group whereas GDNF, GFRα1, TUBB3, NME1 and FGF1 mRNA expression were greatly lower than those in control group; Bim, PDCD4, WT1, RGS4, Axin, KAI1, E-cadherin, PPARγ and PTEN mRNA expression in cisplatin + Par-4 group were greatly higher than those in cisplatin group and Par-4 group whereas GDNF, GFRα1, TUBB3, NME1 and FGF1 mRNA expression were greatly significantly lower than those in cisplatin group and Par-4 group. Conclusion: Par-4 gene overexpression can increase the nephroblastoma sensitivity to cisplatin, reduce cell proliferation activity, promote apoptosis and inhibit cell migration and invasion.
Nanomechanical recognition of prognostic biomarker suPAR with DVD-ROM optical technology

International Nuclear Information System (INIS)

Bache, Michael; Bosco, Filippo G; Brøgger, Anna L; Frøhling, Kasper B; Boisen, Anja; Alstrøm, Tommy Sonne; Hwu, En-Te; Chen, Ching-Hsiu; Hwang, Ing-Shouh; Eugen-Olsen, Jesper

2013-01-01

In this work the use of a high-throughput nanomechanical detection system based on a DVD-ROM optical drive and cantilever sensors is presented for the detection of urokinase plasminogen activator receptor inflammatory biomarker (uPAR). Several large scale studies have linked elevated levels of soluble uPAR (suPAR) to infectious diseases, such as HIV, and certain types of cancer. Using hundreds of cantilevers and a DVD-based platform, cantilever deflection response from antibody–antigen recognition is investigated as a function of suPAR concentration. The goal is to provide a cheap and portable detection platform which can carry valuable prognostic information. In order to optimize the cantilever response the antibody immobilization and unspecific binding are initially characterized using quartz crystal microbalance technology. Also, the choice of antibody is explored in order to generate the largest surface stress on the cantilevers, thus increasing the signal. Using optimized experimental conditions the lowest detectable suPAR concentration is currently around 5 nM. The results reveal promising research strategies for the implementation of specific biochemical assays in a portable and high-throughput microsensor-based detection platform. (paper)
Effect of a physical activity intervention on suPAR levels

DEFF Research Database (Denmark)

Rohde, Christopher; Polcwiartek, Christoffer; Andersen, Eivind

2018-01-01

OBJECTIVES: Soluble urokinase-type plasminogen activator receptor (suPAR) is a novel inflammatory marker, associated with lifestyle diseases and mortality risk. No studies have investigated whether physical activity may reduce suPAR levels using a randomized controlled design. DESIGN AND METHODS......: suPAR and C-reactive protein (CRP) levels were determined in blood samples from a previous randomized controlled trial with Pakistani immigrants in Norway, 2008. The study included physically inactive men that were randomized to an intervention group (supervised group exercises) or a control group...... and followed for 5 months. A linear regression model was used and adjusted for age, inactivity level at baseline, and mean difference in CRP levels. RESULTS: Overall, 80 and 53 participants were included in the intervention and control group, respectively. Obesity and smoking were associated with higher su...
uPAR Expression Pattern in Patients with Urothelial Carcinoma of the Bladder

DEFF Research Database (Denmark)

Dohn, Line Hammer; Pappot, Helle; Iversen, Benedikte Richter

2015-01-01

The objective of the present study was to confirm the expression and localisation pattern of the urokinase-type plasminogen activator receptor (uPAR) focusing on its possible clinical relevance in patients with urothelial neoplasia of the bladder. uPAR is a central molecule in tissue remodelling...... during cancer invasion and metastasis and is an established prognostic marker in various cancer diseases other than bladder cancer. Formalin-fixed and paraffin-embedded tumour-tissue blocks from 186 patients treated with radical cystectomy were analysed. uPAR expression was scored as either negative...... or positive as well as by the actual score. Separate scores were obtained for cancer cells, macrophages and myofibroblasts at the invasive front and in tumour core. We were able to confirm, in an independent patient cohort, the tissue expression and localisation pattern of uPAR as investigated...
uPA/uPAR system activation drives a glycolytic phenotype in melanoma cells.

Science.gov (United States)

Laurenzana, Anna; Chillà, Anastasia; Luciani, Cristina; Peppicelli, Silvia; Biagioni, Alessio; Bianchini, Francesca; Tenedini, Elena; Torre, Eugenio; Mocali, Alessandra; Calorini, Lido; Margheri, Francesca; Fibbi, Gabriella; Del Rosso, Mario

2017-09-15

In this manuscript, we show the involvement of the uPA/uPAR system in the regulation of aerobic glycolysis of melanoma cells. uPAR over-expression in human melanoma cells controls an invasive and glycolytic phenotype in normoxic conditions. uPAR down-regulation by siRNA or its uncoupling from integrins, and hence from integrin-linked tyrosine kinase receptors (IL-TKRs), by an antagonist peptide induced a striking inhibition of the PI3K/AKT/mTOR/HIF1α pathway, resulting into impairment of glucose uptake, decrease of several glycolytic enzymes and of PKM2, a checkpoint that controls metabolism of cancer cells. Further, binding of uPA to uPAR regulates expression of molecules that govern cell invasion, including extracellular matrix metallo-proteinases inducer (EMPPRIN) and enolase, a glycolytyc enzyme that also serves as a plasminogen receptor, thus providing a common denominator between tumor metabolism and phenotypic invasive features. Such effects depend on the α5β1-integrin-mediated uPAR connection with EGFR in melanoma cells with engagement of the PI3K-mTOR-HIFα pathway. HIF-1α trans-activates genes whose products mediate tumor invasion and glycolysis, thus providing the common denominator between melanoma metabolism and its invasive features. These findings unveil a unrecognized interaction between the invasion-related uPAR and IL-TKRs in the control of glycolysis and disclose a new pharmacological target (i.e., uPAR/IL-TKRs axis) for the therapy of melanoma. © 2017 UICC.
uPAR Expression Pattern in Patients with Urothelial Carcinoma of the Bladder--Possible Clinical Implications.

Directory of Open Access Journals (Sweden)

Line Hammer Dohn

Full Text Available The objective of the present study was to confirm the expression and localisation pattern of the urokinase-type plasminogen activator receptor (uPAR focusing on its possible clinical relevance in patients with urothelial neoplasia of the bladder. uPAR is a central molecule in tissue remodelling during cancer invasion and metastasis and is an established prognostic marker in various cancer diseases other than bladder cancer. Formalin-fixed and paraffin-embedded tumour-tissue blocks from 186 patients treated with radical cystectomy were analysed. uPAR expression was scored as either negative or positive as well as by the actual score. Separate scores were obtained for cancer cells, macrophages and myofibroblasts at the invasive front and in tumour core. We were able to confirm, in an independent patient cohort, the tissue expression and localisation pattern of uPAR as investigated by Immunohistochemistry as well as a significant association between uPAR positivity and increasing tumour stage and tumour grade. This demonstrates the robustness of our previous and current findings. In addition the association between uPAR positive myofibroblasts and poor survival was reproduced. The highest hazard ratios for survival were seen for uPAR positive myofibroblasts both at the invasive front and in tumour core. Evaluating uPAR expression by the actual score showed a significant association between uPAR positive myofibroblasts in tumour core and an increased risk of cancer specific mortality. Our investigations have generated new and valuable biological information about the cell types being involved in tumour invasion and progression through the plasminogen activation system.
Proteinase-Activated Receptor-1 and Immunomodulatory Effects of a PAR1-Activating Peptide in a Mouse Model of Prostatitis

Science.gov (United States)

Stanton, M. Mark; Nelson, Lisa K.; Benediktsson, Hallgrimur; Hollenberg, Morley D.; Buret, Andre G.; Ceri, Howard

2013-01-01

Background. Nonbacterial prostatitis has no established etiology. We hypothesized that proteinase-activated receptor-1 (PAR1) can play a role in prostatitis. We therefore investigated the effects of PAR1 stimulation in the context of a new model of murine nonbacterial prostatitis. Methods. Using a hapten (ethanol-dinitrobenzene sulfonic acid- (DNBS-)) induced prostatitis model with both wild-type and PAR1-null mice, we examined (1) the location of PAR1 in the mouse prostate and (2) the impact of a PAR1-activating peptide (TFLLR-NH2: PAR1-TF) on ethanol-DNBS-induced inflammation. Results. Ethanol-DNBS-induced inflammation was maximal at 2 days. In the tissue, PAR1 was expressed predominantly along the apical acini of prostatic epithelium. Although PAR1-TF on its own did not cause inflammation, its coadministration with ethanol-DNBS reduced all indices of acute prostatitis. Further, PAR1-TF administration doubled the prostatic production of interleukin-10 (IL-10) compared with ethanol-DNBS treatment alone. This enhanced IL-10 was not observed in PAR1-null mice and was not caused by the reverse-sequence receptor-inactive peptide, RLLFT-NH2. Surprisingly, PAR1-TF, also diminished ethanol-DNBS-induced inflammation in PAR1-null mice. Conclusions. PAR1 is expressed in the mouse prostate and its activation by PAR1-TF elicits immunomodulatory effects during ethanol-DNBS-induced prostatitis. However, PAR1-TF also diminishes ethanol-DNBS-induced inflammation via a non-PAR1 mechanism by activating an as-yet unknown receptor. PMID:24459330
Solar PAR and UVR modify the community composition and photosynthetic activity of sea ice algae.

Science.gov (United States)

Enberg, Sara; Piiparinen, Jonna; Majaneva, Markus; Vähätalo, Anssi V; Autio, Riitta; Rintala, Janne-Markus

2015-10-01

The effects of increased photosynthetically active radiation (PAR) and ultraviolet radiation (UVR) on species diversity, biomass and photosynthetic activity were studied in fast ice algal communities. The experimental set-up consisted of nine 1.44 m(2) squares with three treatments: untreated with natural snow cover (UNT), snow-free (PAR + UVR) and snow-free ice covered with a UV screen (PAR). The total algal biomass, dominated by diatoms and dinoflagellates, increased in all treatments during the experiment. However, the smaller biomass growth in the top 10-cm layer of the PAR + UVR treatment compared with the PAR treatment indicated the negative effect of UVR. Scrippsiella complex (mainly Scrippsiella hangoei, Biecheleria baltica and Gymnodinium corollarium) showed UV sensitivity in the top 5-cm layer, whereas Heterocapsa arctica ssp. frigida and green algae showed sensitivity to both PAR and UVR. The photosynthetic activity was highest in the top 5-cm layer of the PAR treatment, where the biomass of the pennate diatom Nitzschia frigida increased, indicating the UV sensitivity of this species. This study shows that UVR is one of the controlling factors of algal communities in Baltic Sea ice, and that increased availability of PAR together with UVR exclusion can cause changes in algal biomass, photosynthetic activity and community composition. © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Heavy water moderated gas-cooled reactors; Filiere eau lourde - gaz

Energy Technology Data Exchange (ETDEWEB)

Bailly du Bois, B; Bernard, J L; Naudet, R; Roche, R [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

France has based its main effort for the production of nuclear energy on natural Uranium Graphite-moderated gas-cooled reactors, and has a long term programme for fast reactors, but this country is also engaged in the development of heavy water moderated gas-cooled reactors which appear to present the best middle term prospects. The economy of these reactors, as in the case of Graphite, arises from the use of natural or very slightly enriched Uranium; heavy water can take the best advantages of this fuel cycle and moreover offers considerable development potential because of better reactor performances. A prototype plant EL 4 (70 MW) is under construction and is described in detail in another paper. The present one deals with the programme devoted to the development of this reactor type in France. Reasons for selecting this reactor type are given in the first part: advantages and difficulties are underlined. After reviewing the main technological problems and the Research and Development carried out, results already obtained and points still to be confirmed are reported. The construction of EL 4 is an important step of this programme: it will be a significant demonstration of reactor performances and will afford many experimentation opportunities. Now the design of large power reactors is to be considered. Extension and improvements of the mechanical structures used for EL 4 are under study, as well as alternative concepts. The paper gives some data for a large reactor in the present state of technology, as a result from optimization studies. Technical improvements, especially in the field of materials could lead to even more interesting performances. Some prospects are mentioned for the long run. Investment costs and fuel cycles are discussed in the last part. (authors) [French] La France, qui a base son effort principal pour la production d'energie nucleaire sur la filiere des reacteurs a uranium naturel et graphite refroidis par gaz, et qui a un programme a plus
PAR-Complex and Crumbs Function During Photoreceptor Morphogenesis and Retinal Degeneration.

Science.gov (United States)

Pichaud, Franck

2018-01-01

The fly photoreceptor has long been used as a model to study sensory neuron morphogenesis and retinal degeneration. In particular, elucidating how these cells are built continues to help further our understanding of the mechanisms of polarized cell morphogenesis, intracellular trafficking and the causes of human retinal pathologies. The conserved PAR complex, which in flies consists of Cdc42-PAR6-aPKC-Bazooka, and the transmembrane protein Crumbs (Crb) are key players during photoreceptor morphogenesis. While the PAR complex regulates polarity in many cell types, Crb function in polarity is relatively specific to epithelial cells. Together Cdc42-PAR6-aPKC-Bazooka and Crb orchestrate the differentiation of the photoreceptor apical membrane (AM) and zonula adherens (ZA) , thus allowing these cells to assemble into a neuro-epithelial lattice. In addition to its function in epithelial polarity, Crb has also been shown to protect fly photoreceptors from light-induced degeneration, a process linked to Rhodopsin expression and trafficking. Remarkably, mutations in the human Crumbs1 (CRB1) gene lead to retinal degeneration, making the fly photoreceptor a powerful disease model system.
Potential Ecological Effects of Contaminants in the Exposed Par Pond Sediments

International Nuclear Information System (INIS)

Paller, M.H.; Wike, L.D.

1996-08-01

Sediment and small mammal samples were collected from the exposed sediments of Par Pond in early 1995, shortly before the reservoir was refilled after a 4-year drawdown. Sampling was confined to elevations between 58 and 61 meters (190 and 200 feet) above mean sea level, which includes the sediments likely to be exposed if the Par Pond water level is permitted to fluctuate naturally. Both soil and small mammal samples were analyzed for a number of radionuclides and metals. Some of the soil samples were also analyzed for organic contaminants. The objective of the study was to determine if contaminant levels in the Par Pond sediments were high enough to cause deleterious ecological effects
The pars intermedia: an anatomic basis for a coordinated vascular response to female genital arousal.

Science.gov (United States)

Shih, Cheryl; Cold, Christopher J; Yang, Claire C

2013-06-01

The pars intermedia is an area of the vulva that has been inconsistently described in the literature. We conducted anatomic studies to better describe the tissues and vascular structures of the pars intermedia and proposed a functional rationale of the pars intermedia in the female sexual response. Nine cadaveric vulvectomy specimens were used. Each was serially sectioned and stained with hematoxylin and eosin and Masson's trichrome. Histologic ultrastructural description of the pars intermedia. The pars intermedia contains veins traveling longitudinally in the angle of the clitoris, supported by collagen-rich stromal tissues. These veins drain the different vascular compartments of the vulva, including the clitoris, the bulbs, and labia minora; also, the interconnecting veins link the different vascular compartments. The pars intermedia is not composed of erectile tissue, distinguishing it from the erectile tissues of the corpora cavernosa of the clitoris as well as the corpus spongiosum of the clitoral (vestibular) bulbs. The venous communications of the pars intermedia, linking the erectile tissues with the other vascular compartments of the vulva, appear to provide the anatomic basis for a coordinated vascular response during female sexual arousal. © 2012 International Society for Sexual Medicine.
PAR-1 and thrombin: the ties that bind the microenvironment to melanoma metastasis.

Science.gov (United States)

Zigler, Maya; Kamiya, Takafumi; Brantley, Emily C; Villares, Gabriel J; Bar-Eli, Menashe

2011-11-01

Progression of melanoma is dependent on cross-talk between tumor cells and the adjacent microenvironment. The thrombin receptor, protease-activated receptor-1 (PAR-1), plays a key role in exerting this function during melanoma progression. PAR-1 and its activating factors, which are expressed on tumor cells and the surrounding stroma, induce not only coagulation but also cell signaling, which promotes the metastatic phenotype. Several adhesion molecules, cytokines, growth factors, and proteases have recently been identified as downstream targets of PAR-1 and have been shown to modulate interactions between tumor cells and the microenvironment in the process of melanoma growth and metastasis. Inhibiting such interactions by targeting PAR-1 could potentially be a useful therapeutic modality for melanoma patients. ©2011 AACR.
SECHAGE DE PRODUITS GRANULAIRES PAR DESHYDRATATION PAR DETENTES SUCCESSIVES (DDS)

OpenAIRE

Abdulla , Galal; Mellouk , Hamid; Belghit , Abdelhamid; Allaf , Karim

2009-01-01

International audience; Dans cette étude, nous avons évalué les performances d'un nouveau procédé de séchage dans le cas du liège en granulés. Ce procédé (La déshydratation par détentes successives : DDS) consiste à soumettre le matériau liège dans une chambre hermétique aux variations cycliques de la pression. Chaque cycle est composé d'une compression et d'une décompression. La phase de compression est réalisée en injectant de l'air comprimé à température ambiante provenant d'un compresseur...
Par Pond vegetation status summer 1995 - July survey descriptive summary

International Nuclear Information System (INIS)

Mackey, H.E. Jr.; Riley, R.S.

1995-07-01

A survey of the emergent shoreline aquatic plant, communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet (61 meters) above mean sea level, and continued with this July survey. Aquatic plant communities, similar to the pre-drawdown Par Pond communities, are becoming reestablished. Beds of maidencane (Panicum hemitomon), lotus (Nelumbo lutea), water lily (Nymphaea odorata), and watershield (Brasenia schreberi) are now extensive and well established. In addition, within isolated coves, extensive beds of water lilies and spike-rush (Eleocharis sp.) are common. Cattail occurrence has increased since refill, but large beds common to Par Pond prior to the drawdown have not formed. Invasion of willow (Salix sp.) and red maple (Acer rubrum) occurred along the lake shoreline during drawdown. The red maples along the present shoreline are beginning to show evidence of stress and mortality from flooding over the past four months. Some of the willows appear to be stressed as well. The loblolly pines (Pinus taeda), which were flooded in all but the shallow shoreline areas, are now dead. Future surveys are planned for the growing seasons of 1995, 1996, and 1997, along with the evaluation of satellite data for mapping the areal extent of the macrophyte beds of Par Pond
Presence de Carbone-13 dans les elements combustibles de type (U,Pu)O 2 irradies en reacteur rapide

Science.gov (United States)

Kryger, Bernard; Hagemann, Robert

1982-06-01

Du carbone-13 produit par la réaction de capture neutronique 168O + 10n → 136C + 42He se forme dans les combustibles de type oxyde irradiés en neutrons rapides. Cette réaction, dont le seuil d'énergie se situe à 2.35 MeV, conduit à la formation d'une quantité de carbone-13 qui peut varier notablement suivant le spectre neutronique du réacteur (entre 20 et 40 × 10 -6g 13C/g (U,Pu)O 2 pour une fluence de 2 × 10 23 n/cm 2). DES mesures effectuées sur le combustible et la gaine par spectrométrie de masse après irradiation montrent qu'une fraction égale ou supérieure à la moitié du carbone-13 produit dans l'oxyde peut être transférée dans la gaine. Un tel comportement nous fait considérer le carbone-13 comme un véritable marqueur du carbone plus généralement contenu dans l'oxyde et, à ce titre, la détection de cet isotope devrait contribuer à élucider tout particulièrement les mécanismes de carburation de la gaine par les combustibles (U,Pu)O 2 des réacteurs surgénérateurs.
Project Plan 7930 Cell G PaR Remote Handling System Replacement

International Nuclear Information System (INIS)

Kinney, Kathryn A.

2009-01-01

For over 40 years the US Department of Energy (DOE) and its predecessors have made Californium-252 ( 252 Cf) available for a wide range of industries including medical, nuclear fuels, mining, military and national security. The Radiochemical Engineering Development Center (REDC) located within the Oak Ridge National Laboratory (ORNL) processes irradiated production targets from the High Flux Isotope Reactor (HFIR). Operations in Building 7930, Cell G provide over 70% of the world's demand for 252 Cf. Building 7930 was constructed and equipped in the mid-1960s. Current operations for 252 Cf processing in Building 7930, Cell G require use of through-the-wall manipulators and the PaR Remote Handling System. Maintenance and repairs for the manipulators is readily accomplished by removal of the manipulator and relocation to a repair shop where hands-on work can be performed in glove boxes. Contamination inside cell G does not currently allow manned entry and no provisions were created for a maintenance area inside the cell. There has been no maintenance of the PaR system or upgrades, leaving operations vulnerable should the system have a catastrophic failure. The Cell G PaR system is currently being operated in a run to failure mode. As the manipulator is now 40+ years old there is significant risk in this method of operation. In 2006 an assessment was completed that resulted in recommendations for replacing the manipulator operator control and power centers which are used to control and power the PaR manipulator in Cell G. In mid-2008 the chain for the bridge drive failed and subsequent examinations indicated several damaged links (see Figure 1). To continue operations the PaR manipulator arm is being used to push and pull the bridge as a workaround. A retrieval tool was fabricated, tested and staged inside Cell G that will allow positioning of the bridge and manipulator arm for removal from the cell should the PaR system completely fail. A fully functioning and

PAR-1 mediated apoptosis of breast cancer cells by V. cholerae hemagglutinin protease.

Science.gov (United States)

Ray, Tanusree; Pal, Amit

2016-05-01

Bacterial toxins have emerged as promising agents in cancer treatment strategy. Hemagglutinin (HAP) protease secreted by Vibrio cholerae induced apoptosis in breast cancer cells and regresses tumor growth in mice model. The success of novel cancer therapies depends on their selectivity for cancer cells with limited toxicity for normal tissues. Increased expression of Protease Activated Receptor-1 (PAR-1) has been reported in different malignant cells. In this study we report that HAP induced activation and over expression of PAR-1 in breast cancer cells (EAC). Immunoprecipitation studies have shown that HAP specifically binds with PAR-1. HAP mediated activation of PAR-1 caused nuclear translocation of p50-p65 and the phosphorylation of p38 which triggered the activation of NFκB and MAP kinase signaling pathways. These signaling pathways enhanced the cellular ROS level in malignant cells that induced the intrinsic pathway of cell apoptosis. PAR-1 mediated apoptosis by HAP of malignant breast cells without effecting normal healthy cells in the same environment makes it a good therapeutic agent for treatment of cancer.
Comparative study of thyroid fixation of different iodine compounds; Etude comparative de la fixation thyroidienne de differents composes iodes

Energy Technology Data Exchange (ETDEWEB)

Rinaldi, R; Coeur, A; Raynfeld, Ch [Commissariat a l' Energie Atomique, Grenoble (France).Centre d' Etudes Nucleaires

1961-07-01

The aim of this work is to study the thyroid fixation of various iodine compounds in mineral or organic form. The animals (rats) are given therapeutic doses of the derivative orally with the object of saturating the thyroid, and then receive a determined dose of radio-iodine 131 by intra-peritoneal injection; any fixation of this latter is then measured under anaesthetic by means of a scintillation counter. Whatever form of iodine derivative was used whether in ionic (potassium iodide type) or organic form (iodo-tannic syrup) or in the form of elementary iodine (iodinated water), thyroid saturation was always obtained, as shown by practically zero fixation of the 4 {mu}curies of iodine 131 administered by intra-peritoneal injection. (author) [French] Notre travail a pour but l'etude de la fixation thyroidienne de differents composes iodes sous forme minerale ou organique. Les animaux (rats), apres absorption orale de doses therapeutiques de derives destines a saturer leur thyroide recoivent par voie intra-peritoneale une dose determinee de radio-iode {sup 131}I, la fixation eventuelle de ce dernier est ensuite mesuree sous anesthesie en utilisant un compteur a scintillation. Quelle que soit la forme utilisee, c'est-a-dire derive iode sous forme ionique (type iodure de potassium) ou sous forme organique (sirop iodotanique) ou encore sous forme d'iode metalloidique (eau iodee), nous avons obtenu chaque fois une saturation thyroidienne mise en evidence par une fixation pratiquement nulle des 4 {mu}curies de l'iode 131 injectes par voie intraperitoneale. (auteur)
New Instruments and Principles for the Dimensional Measurement and Measurement of Spacing of Reactor Components; Nouveaux Instruments et Procedes de Mesure des Dimensions et de l'Espacement des Elements d'un Reacteur; Novye pribory i printsipy izmereniya razmerov i raspolozheniya komponentov reaktora; Nuevos Instrumentos y Principios para Medir las Dimensiones y la Separacion Entre Componentes de Reactor

Energy Technology Data Exchange (ETDEWEB)

Mueller, P. [Institut Dr. Foerster, Reutlingen, Federal Republic of Germany (Germany)

1965-09-15

instrument for reactor components are discussed. Special attention is given to the possibility of using a small and versatile pick-up by means of manipulators in the ''hot'' zones and on ''hot'' materials. The increase of surface roughness with increasing irradiation dose is discussed. (author) [French] Full text: L'auteur presente les problemes de mesure de l'epaisseur de feuilles et des parois de tubes et recipients en aciers austenitiques ou en metaux non ferreux. Deux methodes de mesure des epaisseurs sans contact sont discutees: la mesure, par courants de Foucault, de l'epaisseur de feuilles et des parois de recipients en metaux non ferreux ou en aciers austenitiques, au moyen de bobines se deplacant le long des pieces a examiner: la mesure, par courants de Foucault, de l'epaisseur des parois de tubes, au moyen de bobines dans lesquelles se deplacent les pieces a examiner. L'auteur decrit des instruments appropries et le mode d'utilisation. Il discute egalement la mesure de l'epaisseur des parois de parties constitutives de reacteurs, en metaux non ferreux, par la 'methode de la bille magnetique' et explique le principe de ce nouveau type de mesure et son domaine d'utilisation - notamment pour les mesures par points; il decrit un instrument approprie. L'auteur examine la mesure des revetements non magnetiques de materiaux magnetiques; il explique les principes de mesure (methodes fondees sur les champs magnetiques des courants continus et des courants alternatifs) et decrit des instruments de mesure de revetements non magnetiques dont l'epaisseur varie entre 3 {mu}m et 20 mm. Il expose le probleme special de la mesure des depots de stellite sur les parois en aciers ferritiques des cuves de reacteurs. La mesure des revetements non conducteurs de metaux non ferreux est etudiee. Le memoire explique le principe de mesure (courants de Foucault). Il decrit un instrument approprie et donne des exemples de mesures typiques. L'auteur examine egalement la mesure sans contact, en
Contribution to the isotopic analysis of nitrogen using optical spectrometry; Contribution a l'analyse isotopique de l'azote par spectrometrie optique

Energy Technology Data Exchange (ETDEWEB)

Leicknam, J P [Commissariat a l' Energie Atomique, 91 - Saclay (France). Centre d' Etudes Nucleaires

1968-07-01

15 (abondances isotopiques inferieures a 2 pour cent), les methodes proposees jusqu'alors ne donnaient pas rapidement des resultats suffisamment precis. Cette analyse isotopique ne necessite qu'un spectrometre de moyenne resolution; on peut meme, comme nous l'avons fait, utiliser un spectrographe en substituant a la plaque photographique une fente de sortie, suivie d'un photomultiplicateur; cette transformation est tres simple a realiser et les signaux provenant du detecteur peuvent alors etre envoyes sur un enregistreur. Dans ces conditions la duree d'une determination ne demande que de trois a dix minutes, suivant la precision desiree. Les sources de lumiere sont constituees par des lampes a decharge sans electrode, excitees par haute frequence; les conditions de remplissage sont telles que l'on peut preparer des lampes en quelques minutes, les impuretes etant suffisamment eliminees pour ne pas perturber les mesures. Le choix du couple de bandes d'analyse tient compte de la position relative des bandes isotopiques et de la presence eventuelle de traces de ces impuretes: parmi les transitions du systeme C({sup 3}{pi}{sub u}) <-> B({sup 3}{pi}{sub g}), la transition 2 {yields} 0 presente la disposition la plus favorable pour effectuer ce dosage isotopique. La methode est appliquee a des echantillons de diverses provenances (sels ammoniacaux, engrais et plantes): les teneurs isotopiques sont determinees a 3 pour cent pres au voisinage de l'abondance naturelle et a 1 pour cent pres lorsque l'echantillon contient environ 1.5 atomes d'azote 15 pour 100 atomes d'azote 14. La precision est donc largement suffisante pour la plupart des etudes biologiques utilisant, l'atome 15 comme traceur. (auteur)
Comparaison du Pangola (Digitaria decumbens) et du Stargrass (Cynodon nlemfluensis) exploités par des ovins

OpenAIRE

Boval, Maryline

1989-01-01

A la Martinique l'utilisation comparée de Digitaria decumbens (Dd) et de Cynodon nlemfuensis (Cn) par des brebis allaitantes a été étudiée pendant une période d'observation de 6 mois. Le cheptel est à un taux élevé de 1 600 kg de poids vif par hectare et par an, obtenu par une fertilisation de 450 kg/ha/an en azote.
ParFit: A Python-Based Object-Oriented Program for Fitting Molecular Mechanics Parameters to ab Initio Data.

Science.gov (United States)

Zahariev, Federico; De Silva, Nuwan; Gordon, Mark S; Windus, Theresa L; Dick-Perez, Marilu

2017-03-27

A newly created object-oriented program for automating the process of fitting molecular-mechanics parameters to ab initio data, termed ParFit, is presented. ParFit uses a hybrid of deterministic and stochastic genetic algorithms. ParFit can simultaneously handle several molecular-mechanics parameters in multiple molecules and can also apply symmetric and antisymmetric constraints on the optimized parameters. The simultaneous handling of several molecules enhances the transferability of the fitted parameters. ParFit is written in Python, uses a rich set of standard and nonstandard Python libraries, and can be run in parallel on multicore computer systems. As an example, a series of phosphine oxides, important for metal extraction chemistry, are parametrized using ParFit. ParFit is in an open source program available for free on GitHub ( https://github.com/fzahari/ParFit ).
Application of passive auto catalytic recombiner (PAR) for BWR plants in Japan

International Nuclear Information System (INIS)

Kobayashi, K.; Murano, K.; Yamanari, S.; Yamamoto, Y.

2001-01-01

The passive auto-catalytic recombiner (PAR), which can recombine flammable gases such as hydrogen and oxygen with each other to avoid an explosion in case of a loss-of-coolant accident (LOCA), installed in the primary containment vessel does not require a power supply or dynamic equipment, while the existing flammability gas control system (FCS) of most BWRs as an outer loop of the primary containment vessel needs them to make flammable gases circulate through blowers and heaters in the system. PAR offers a number of advantages over existing FCS, such as high reliability, low cost due to much smaller amount of materials needed, good maintainability, good operability in case of a LOCA, and smaller space for installation. An experimental study has been carried out for the purpose of solving the problems of applying PAR to Japanese BWR plants instead of existing FCS, in which we grasped the basic characteristics of PAR. (author)
Improvements of the sensitivity of burst cartridge detection; Amelioration du seuil de detection des ruptures de gaine

Energy Technology Data Exchange (ETDEWEB)

Vasnier, F [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1967-07-01

I - Special tests for improving the sensitivity of burst cartridge detection equipment in power reactors II - Scintillator purge-flow tests using aged gas in the B.C.D. /E.D.F. 2 Summary. - The first part of this report describes the tests carried out on fission product detectors by a process in which gas is continuously injected in front of the scintillator. Using this system, the background is reduced and perturbations caused by pneumatic switches on the prospecting circuits are eliminated. The quality of the signals thus obtained permits better processing of the data and thus leads to a possible improvement in the sensitivity of burst cartridge detection. The second part gives results of tests carried out with both fresh and aged gases, the economic advantage of the latter being that it permits recycling through the reactor. Reduction of the background is less pronounced but the advantage of the stable signals is conserved. (author) [French] I - Essais speciaux pour ameliorer le seuil de detection des installations de D.R.G. des reacteurs de puissance II- Essais de balayage sous scintillateur avec gaz vieilli a la D.R.G. /E.D.F. 2 Sommaire. - La premiere partie de ce rapport decrit les essais effectues sur les detecteurs de produits de fission par un procede d'injection continue de gaz sous le scintillateur. Grace a ce systeme on obtient une reduction du bruit de fond et l'elimination des perturbations causees par les commutations pneumatiques des circuits de prospection. La qualite des signaux obtenus ainsi permet un meilleur traitement des informations d'ou une amelioration possible du seuil de detection des ruptures de gaines. La seconde partie donne les resultats d'essais effectues avec du gaz propre et vieilli, l'utilisation de ce dernier presentant l'avantage economique d'etre recycle du reacteur. La reduction du bruit de fond est moins importante mais on conserve l'avantage de la stabilisation des signaux. (auteur)
A Survey of the Fuel Cycles Operated in the United Kingdom; Etude d'ensemble sur les cycles de combustible au Royaume-Uni; Obzor toplivnykh tsiklov, ispol'zuemykh v soedinennom korolevstve; Estudio de los ciclos de combustible utilizados en el Reino Unido

Energy Technology Data Exchange (ETDEWEB)

Allday, C. [United Kingdom Atomic Energy Authority, Risley, Warrington, Lancs (United Kingdom)

1963-10-15

son programme d'energie d'origine nucleaire sur la filie re des reacteurs a l'uranium naturel et au graphite, refroidis par un gaz. Les reacteurs de Calder Hall et de Chapelcross fonctionnent depuis sept ans; ceux de Berkeley et de Bradwell, qui dependent du Central Electricity Generating Board (CEGB), sont maintenant en service et sept autres reacteurs sont en construction ou en projet. Le combustible destine a ces reacteurs est etudie et fabrique dans l'usine de l'Atomic Energy Authority (AEA) a Springfields, puis transporte jusqu'au reacteur. Apres irradiation et dechargement, le combustible est transporte a l'usine de l'AEA, situee a Windscale, ou l'uranium et le plutonium sont separes des produits de fission. L'auteur decrit l'experience britannique en matiere d'etude et de fabrication du combustible, d'exploitation du reacteur, de transport et de traitement chimique du combustible irradie. Il examine brievement le comportement du combustible dans le reacteur et les differents programmes possibles de chargement et de dechargement, ce sujet etant developpe dans un autre memoire. b) Reacteurs utilisant les combustibles enrichis. Le Royaume-Uni met au point un reacteur perfectionne refroidi par un gaz (Advanced Gas Cooled Reactor = AGR), dont le prototype a ete mis en service en 1963. Le combustible est fabrique a partir d'oxyde d'uranium enrichi gaine d' acier inoxydable; apres irradiation, il sera traite dans une novelle installation qui sera ajoutee a l'usine de separation de Windscale ou est actu ellement traite le combustible gaine de magnox. L'uranium enrichi destine a AGR est produit par l'usine de diffusion situee a Capenhurst. L'oxyde d'uranium naturel enrichi au plutonium peut remplacer, comme combustible, l'oxyde d'uranium enrichi. L'auteur decrit l'experience acquise dans la transformation de l'oxyde destine a AGR et dans le fonctionnement du reacteur et indique comment on envisage de traiter le combustible irradie. Il examine le cas de l'utilisation d
Pars plana Ahmed valve and vitrectomy in patients with glaucoma associated with posterior segment disease.

Science.gov (United States)

Wallsh, Josh O; Gallemore, Ron P; Taban, Mehran; Hu, Charles; Sharareh, Behnam

2013-01-01

To assess the safety and efficacy of a modified technique for pars plana placement of the Ahmed valve in combination with pars plana vitrectomy in the treatment of glaucoma associated with posterior segment disease. Thirty-nine eyes with glaucoma associated with posterior segment disease underwent pars plana vitrectomy combined with Ahmed valve placement. All valves were placed in the pars plana using a modified technique, without the pars plana clip, and using a scleral patch graft. The 24 eyes diagnosed with neovascular glaucoma had an improvement in intraocular pressure from 37.6 mmHg to 13.8 mmHg and best-corrected visual acuity from 2.13 logarithm of minimum angle of resolution to 1.40 logarithm of minimum angle of resolution. Fifteen eyes diagnosed with steroid-induced glaucoma had an improvement in intraocular pressure from 27.9 mmHg to 14.1 mmHg and best-corrected visual acuity from 1.38 logarithm of minimum angle of resolution to 1.13 logarithm of minimum angle of resolution. Complications included four cases of cystic bleb formation and one case of choroidal detachment and explantation for hypotony. Ahmed valve placement through the pars plana during vitrectomy is an effective option for managing complex cases of glaucoma without the use of the pars plana clip.
La syphilis congenitale revelee par une fracture spontanee

Directory of Open Access Journals (Sweden)

Mounia Lakhdar Idrissi

2011-11-01

Full Text Available Alors qu�elle est actuellement oubliee dans les pays developpes, la syphilis congenitale se voit encore chez nous faute du depistage antenatal. Ses formes cliniques sont polymorphes et orientent a tord vers d�autres pathologies surtout en periode neonatale. Le diagnostic n�est donc pas toujours facile. La revelation d�une syphilis congenitale par une fracture spontanee est exceptionnellement decrite. Nous rapportons dans ce travail le cas d�un nourrisson de 2 mois ramene en consultation pour limitation douloureuse des mouvements du bras droit. Le diagnostic est evoque sur les donnees radiologiques et confirme par la serologie syphilitique. Le traitement a repose essentiellement sur l�administration de la penicilline G avec une bonne evolution clinique.
[Roles of protease-activated receptor-2 (PAR-2), a G protein-coupled receptor, in modulation of exocrine gland functions].

Science.gov (United States)

Nishikawa, Hiroyuki

2006-07-01

Protease-activated receptor-2 (PAR-2), a G protein-coupled receptor, is activated by proteolytic unmasking of the N-terminal extracellular tethered ligand that presumably binds to the extracellular loop 2 of the receptor itself. PAR-2 is widely distributed in the mammalian body and plays various roles in biological events in the cardiovascular, respiratory, alimentary, and central neurons systems. PAR-2-activating peptides administered systemically to mice and rats trigger prompt salivation in vivo. In an in vitro study, PAR-2 agonists including the endogenous PAR-2 activator trypsin induce secretion of amylase and mucin from isolated rat parotid glands and sublingual glands, respectively. PAR-2-activating peptides administered systemically also modulate pancreatic exocrine secretion in vivo as well as in vitro. In the gastric mucosa, PAR-2 stimulation enhances secretion of mucus and pepsinogen and suppresses acid secretion. Tear secretion can also be caused by PAR-2-related peptides in PAR-2-dependent and -independent manners. PAR-2 thus plays a general or key role in the regulation of exocrine secretion. This review focuses on the physiologic and/or pathophysiologic roles of PAR-2 in glandular exocrine secretion. The possibility of PAR-2 as a target for drug development is also discussed.
Etk/Bmx regulates proteinase-activated-receptor1 (PAR1 in breast cancer invasion: signaling partners, hierarchy and physiological significance.

Directory of Open Access Journals (Sweden)

Irit Cohen

Full Text Available BACKGROUND: While protease-activated-receptor 1 (PAR(1 plays a central role in tumor progression, little is known about the cell signaling involved. METHODOLOGY/PRINCIPAL FINDINGS: We show here the impact of PAR(1 cellular activities using both an orthotopic mouse mammary xenograft and a colorectal-liver metastasis model in vivo, with biochemical analyses in vitro. Large and highly vascularized tumors were generated by cells over-expressing wt hPar1, Y397Z hPar1, with persistent signaling, or Y381A hPar1 mutant constructs. In contrast, cells over-expressing the truncated form of hPar1, which lacks the cytoplasmic tail, developed small or no tumors, similar to cells expressing empty vector or control untreated cells. Antibody array membranes revealed essential hPar1 partners including Etk/Bmx and Shc. PAR(1 activation induces Etk/Bmx and Shc binding to the receptor C-tail to form a complex. Y/A mutations in the PAR(1 C-tail did not prevent Shc-PAR(1 association, but enhanced the number of liver metastases compared with the already increased metastases obtained with wt hPar1. We found that Etk/Bmx first binds via the PH domain to a region of seven residues, located between C378-S384 in PAR(1 C-tail, enabling subsequent Shc association. Importantly, expression of the hPar1-7A mutant form (substituted A, residues 378-384, which is incapable of binding Etk/Bmx, resulted in inhibition of invasion through Matrigel-coated membranes. Similarly, knocking down Etk/Bmx inhibited PAR(1-induced MDA-MB-435 cell migration. In addition, intact spheroid morphogenesis of MCF10A cells is markedly disrupted by the ectopic expression of wt hPar1. In contrast, the forced expression of the hPar1-7A mutant results in normal ball-shaped spheroids. Thus, by preventing binding of Etk/Bmx to PAR(1 -C-tail, hPar1 oncogenic properties are abrogated. CONCLUSIONS/SIGNIFICANCE: This is the first demonstration that a cytoplasmic portion of the PAR(1 C-tail functions as a scaffold
Comparison of Direct Pars Repair Techniques of Spondylolysis in Pediatric and Adolescent Patients: Pars Compression Screw Versus Pedicle Screw-Rod-Hook.

Science.gov (United States)

Karatas, Ali F; Dede, Ozgur; Atanda, Alfred A; Holmes, Larry; Rogers, Kenneth; Gabos, Peter; Shah, Suken A

2016-08-01

Retrospective clinical cohort study. To compare the clinical and radiographic outcomes of patients who were treated with intrasegmental pars fixation by either laminar compression screw (LS) or a pedicle screw, rod, and laminar hook (PSRH) construct. Spondylolysis is a nonunion defect of the pars interarticularis. In symptomatic spondylolysis, direct repair of the pars interarticularis defect can preserve motion and prevent abnormal stresses at the adjacent levels. Sixteen patients who failed nonoperative treatment and underwent direct pars repair by using LS (n=9) or PSRH (n=7) constructs were included in the study. Clinical outcome was assessed by using the MacNab criteria. Radiologic fusion and complications were evaluated using plain radiographs or computed tomography images and patient charts. The healing rate was 100% after 6 months. The healing time was similar in both the groups: LS, 6.5 months; PSRH, 6.2 months. Patients with PSRH (5.9 mo) were more likely to return to sports earlier relative to patients with LS (7.7 mo). There were no complications in the LS group; in the PSRH group, 1 patient had mild sensory deficit and 2 had superficial wound infections. The MacNab criteria for pain assessment showed an excellent or good outcome in 8 of 9 patients in LS group and 6 of 7 patients in PSRH group. Relative to LS patients, there was a significant increase in surgical time and estimated blood loss among PSRH patients. Either of the mentioned 2 techniques appears to produce acceptable results. Biplanar fluoroscopy and navigation systems could minimize the risk of screw misplacement with LS construct. Familiarity with the various fixation techniques will allow the surgeon to select the most appropriate surgical technique.
PAR-Complex and Crumbs Function During Photoreceptor Morphogenesis and Retinal Degeneration

Directory of Open Access Journals (Sweden)

Franck Pichaud

2018-03-01

Full Text Available The fly photoreceptor has long been used as a model to study sensory neuron morphogenesis and retinal degeneration. In particular, elucidating how these cells are built continues to help further our understanding of the mechanisms of polarized cell morphogenesis, intracellular trafficking and the causes of human retinal pathologies. The conserved PAR complex, which in flies consists of Cdc42-PAR6-aPKC-Bazooka, and the transmembrane protein Crumbs (Crb are key players during photoreceptor morphogenesis. While the PAR complex regulates polarity in many cell types, Crb function in polarity is relatively specific to epithelial cells. Together Cdc42-PAR6-aPKC-Bazooka and Crb orchestrate the differentiation of the photoreceptor apical membrane (AM and zonula adherens (ZA, thus allowing these cells to assemble into a neuro-epithelial lattice. In addition to its function in epithelial polarity, Crb has also been shown to protect fly photoreceptors from light-induced degeneration, a process linked to Rhodopsin expression and trafficking. Remarkably, mutations in the human Crumbs1 (CRB1 gene lead to retinal degeneration, making the fly photoreceptor a powerful disease model system.
L'analyse par activation de neutrons de réacteur

Science.gov (United States)

Meyer, G.

2003-02-01

Quand les neutrons traversent la matière, certains sont transmis sans interaction, les autres interagissent avec le milieu traversé par diffusion et par absorption. Ce phénomène d'absorption est utilisé pour se protéger des neutrons, mais aussi pour les détecter; il peut également être utilisé pour identifier les noyaux “absorbants" et ainsi analyser le milieu traversé. En effet par différentes réactions nucléaires (n,γ), (n,p), (n,α), (n,fission), on obtient des noyaux résiduels qui sont souvent radioactifs; on dit que l'échantillon est “activé". Si l'on connaît le rendement d'activation et donc le pourcentage de noyaux ainsi “transmutés", les mesures de radioactivité induite vont permettre de déterminer la composition de l'échantillon irradié. Cette méthode dite d'analyse par activation neutronique est pratiquée depuis la découverte du neutron. Elle a permis grâce à sa sélectivité et à sa sensibilité d'avoir accès au domaine des traces et des ultra-traces dans des champs d'application très divers comme la métallurgie, l'archéologie, la biologie, la géochimie etc...
Etude par simulation hil des performances d'un statcom pour la ...

African Journals Online (AJOL)

Ce travail présente l'étude par simulation Hardware In the Loop (HIL) des performances d'un STATCOM pour la stabilisation de la tension délivrée par une génératrice asynchrone triphasée auto excitée dans un réseau autonome. Nous avons combiné l'utilisation du logiciel de simulation LABVIEW et la carte ARDUINO ...
Protease activated receptors (PARS) mediation in gyroxin biological activity; Mediacao dos receptores ativados por proteases (PARs) em atividades biologicas da giroxina

Energy Technology Data Exchange (ETDEWEB)

Silva, Jose Alberto Alves da

2009-07-01

Gyroxin is a serine protease enzyme from the South American rattlesnake (Crotalus durissus terrificus) venom; it is only partially characterized and has multiple activities. Gyroxin induces blood coagulation, blood pressure decrease and a neurotoxic behavior named barrel rotation. The mechanisms involved in this neurotoxic activity are not known. Whereas gyroxin is a member of enzymes with high potential to become a new drug with clinical applications such as thrombin, batroxobin, ancrod, tripsyn and kalicrein, it is important to find out how gyroxin works. The analysis on agarose gel electrophoresis and circular dichroism confirmed the molecules' integrity and purity. The gyroxin intravenous administration in mice proved its neurotoxicity (barrel rotation). In vivo studies employing intravital microscopy proved that gyroxin induces vasodilation with the participation of protease activated receptors (PARs), nitric oxide and Na+K+ATPase. The leukocytes' adherence and rolling counting indicated that gyroxin has no pro inflammatory activity. Gyroxin induced platelet aggregation, which was blocked by inhibitors of PAR1 and PAR4 receptors (SCH 79797 and tcY-NH{sub 2}, respectively). Finally, it was proved that the gyroxin temporarily alter the permeability of the blood brain barrier (BBB). Our study has shown that both the protease-activated receptors and nitric oxide are mediators involved in the biological activities of gyroxin. (author)
Un « gouvernement des journalistes par le Pouvoir politique » par défaut ?

Directory of Open Access Journals (Sweden)

Matthieu Lardeau

2013-12-01

Full Text Available Cet article présente les interactions de deux mouvements concomitants apparusprincipalement dans les décennies 1950 à 1970 dans le champ de la presse française : d’un côté les initiatives – consécutives à la démarche pionnière, en 1951, de création de la première Société des journalistes (SDJ au sein du Monde – menées par les journalistes de rédactions de quotidiens pour créer des SDJ dont la destination peut aller jusqu’à gouverner les journaux; de l’autre côté, les « réponses » apportées par les Pouvoirs politique et public pour contenir ces initiatives visant à étendre le pouvoir des journalistes dans la gestion et la gouvernance de leurs journaux. Cette étude exploratoire repose principalement sur l’analyse de deux types de littérature, souvent déconsidérés ou négligés par le champ académique, en dépit de leur grande richesse : (1 la littérature professionnelle, ayant pour principaux auteurs les journalistes et managers de presse (Périer Daville, Boegner, Pigasse, etc., florissante depuis 1944 et singulièrement durant les décennies 1960 et 1970 ; (2 la littérature grise constituée notamment par des rapports publics rédigés par des institutions comme les services du Premier ministre (commissions Lindon de 1970 et Serisé de 1972, le Conseil économique et social, etc. Nos principaux résultats montrent que les propositions ou actions menées par les journalistes (1 restent le plus souvent inexploitées in concreto par les journalistes eux-mêmes; (2 entrent le plus souvent en opposition avec les politiques de nouveaux actionnaires ou directions de journaux et avec les projets des autorités politiques et publiques qui cherchent à encadrer l’autonomie de la profession journalistique pour mieux gouverner celle-ci ; (3 combien in fine les représentants des différents acteurs impliqués s’accordent pour contenir l’émergence d’un « gouvernement des journalistes » par les
Measures and modelling of PAR (photosynthetically-active radiation) for the Northeast of Brazil; Medidas e modelagem da radiacao PAR (photosynthetically-active radiation) para o nordeste do Brasil

Energy Technology Data Exchange (ETDEWEB)

Tiba, Chigueru; Leal, Sergio da S.A. [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Dept. de Energia Nuclear], e-mail: tiba@rce.neoline.com.br

2004-07-01

Photosynthetically active solar radiation, known by its acronym in the English language as PAR, is the principal driving force of innumerable biological and physical processes related to biomass production, such as, the evolution of vegetal covering, agricultural productivity, and countless environment aspects, among others. Unfortunately in Brazil and particularly in the Northeast of Brazil, the PAR radiation measures are not a routine part of meteorological station measures, and therefore are still rarer than solar irradiation measures. In this context, a station was installed in Recife, Pernambuco in 2003, to carry out simultaneous measures of daily solar irradiation and PAR irradiation, which permits the modelling and valuation of the relationship between these two parameters and thus makes the estimation of PAR radiation possible, where there used to be only information on solar irradiation. Three others stations are being installed, one on Fernando de Noronha-PE, another in Pesqueira-PE, and the other in Xingo-SE, which complete a group of 4 between Latitudes 8 deg and 10 deg South and Longitudes 34 deg to 38 deg West, each having differentiated Equatorial Climates: island maritime, continental maritime, sylvan (Agreste) and semi-arid. (author)

A method for estimating the diffuse attenuation coefficient (KdPAR)from paired temperature sensors

Science.gov (United States)

Read, Jordan S.; Rose, Kevin C.; Winslow, Luke A.; Read, Emily K.

2015-01-01

A new method for estimating the diffuse attenuation coefficient for photosynthetically active radiation (KdPAR) from paired temperature sensors was derived. We show that during cases where the attenuation of penetrating shortwave solar radiation is the dominant source of temperature changes, time series measurements of water temperatures at multiple depths (z1 and z2) are related to one another by a linear scaling factor (a). KdPAR can then be estimated by the simple equation KdPAR ln(a)/(z2/z1). A suggested workflow is presented that outlines procedures for calculating KdPAR according to this paired temperature sensor (PTS) method. This method is best suited for conditions when radiative temperature gains are large relative to physical noise. These conditions occur frequently on water bodies with low wind and/or high KdPARs but can be used for other types of lakes during time periods of low wind and/or where spatially redundant measurements of temperatures are available. The optimal vertical placement of temperature sensors according to a priori knowledge of KdPAR is also described. This information can be used to inform the design of future sensor deployments using the PTS method or for campaigns where characterizing sub-daily changes in temperatures is important. The PTS method provides a novel method to characterize light attenuation in aquatic ecosystems without expensive radiometric equipment or the user subjectivity inherent in Secchi depth measurements. This method also can enable the estimation of KdPAR at higher frequencies than many manual monitoring programs allow.
RESOLUTION DU PROBLEME DE PREDICTION LINEAIRE PAR LA METHODE ULV. APPLICATION AU SIGNAL FID

Directory of Open Access Journals (Sweden)

M KHELIF

2003-06-01

Full Text Available Dans le cadre de la spectroscopie RMN, notre objectif est de déterminer le spectre d'absorption du signal de précession libre FID par la méthode de prédiction linéaire (PL. Ceci revient à résoudre le problème de prédiction linéaire en exploitant la méthode de corrélation par l'utilisation de la décomposition en valeurs singulières SVD pour l'inversion de la matrice de corrélation. Or, cette technique est la source d'un certain nombre de problèmes lorsque le signal est noyé dans du bruit. Aussi sera-t-elle coûteuse en temps lorsque les dimensions de la matrice de corrélation sont importantes. Afin de résoudre ce problème, nous exploitons les propriétés d'une nouvelle technique dérivée de la SVD, la décomposition ULV pour minimiser le coût du traitement et assurer une inversion correcte de la matrice de corrélation. Dans ce but, nous déterminons le spectre d'absorption par la technique ULV et nous le comparons avec le spectre déterminé par la SVD et la FFT. Nous comparons par la suite la qualité des spectres obtenus par rapport au spectre d'absorption idéal déterminé par FFT.
Fast neutron dosimetry in research reactors; Dosimetrie en neutrons rapides dans les reacteurs de recherche

Energy Technology Data Exchange (ETDEWEB)

Eckert, R [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

1960-07-01

This work chiefly concerns the measurement of fast neutron fluxes by means of threshold detectors. It is shown first that the cross sections to use for measurements by threshold detectors depend largely on the neutron spectrum, that is the position in which the measurement is performed. The spectrum is determined by calculation for several positions in the piles EL2 and EL3; from this can be deduced the cross-sections to be used for the measurements carried out in these positions. In the last part of the report, possible methods for the experimental determination of the spectrum are indicated. (author) [French] On etudie principalement la mesure des flux de neutrons rapides a l'aide de detecteurs a seuil. On montre d'abord que les sections efficaces a utiliser pour les mesures par detecteurs a seuil, dependent grandement du spectre des neutrons, c'est-a-dire de l'emplacement ou s'effectue la mesure. La determination du spectre est effectuee par le calcul pour plusieurs emplacements des piles EL2 et EL3; on en deduit les sections efficaces a utiliser pour les mesures effectuees a ces emplacements. Dans la derniere partie du rapport, on indique quelles methodes sont possibles pour la determination experimentale du spectre. (auteur)
Study of some ion exchange minerals which can be used in water at high temperature; Etude de quelques echangeurs mineraux utilisables dans l'eau a haute temperature

Energy Technology Data Exchange (ETDEWEB)

Hure, J; Platzer, R; Bittel, R [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Fourre, J [Societe le Carbone Lorraine, 75 - Paris (France); Wey, R [Faculte des Sciences de Strasbourg, Lab. de Mineralogie, 67 (France)

1958-07-01

these impurities (that is to say capable of de-mineralizing polluted water). This paper describes the preliminary results of the investigation. (author) [French] L'etude de l'utilisation des echangeurs d'ions a haute temperature a ete essentiellement faite en vue de l'epuration de l'eau des reacteurs. On connait l'interet qu'il y a a garder dans un circuit de reacteur de l'eau de tres haute resistivite (plusieurs centaines a quelques millions {omega}.cm): abaissement de la corrosion, abaissement du taux de radiolyse, abaissement de la radioactivite des circuits et canalisations, les elements autres que les constituants de l'eau transportes par celle-ci devenant generalement radioactifs par leur passage au coeur du reacteur. Si la circulation d'eau se fait a des temperatures inferieures a 45 deg. C, les resines echangeuses d'ions organiques utilisees en lit melange resolvent tres bien le probleme de l'epuration en continu. Par contre, pour des temperatures plus elevees surtout au-dessus de 100 deg. C, leur utilisation n'est pas possible, la degradation de ces hauts polymeres etant tres rapide. De meme, l'action des rayonnements, par exemple ceux des produits fixes par les echangeurs d'ions, detruit irremediablement les chaines organiques constituant le squelette de ces echangeurs. Nous avons donc cherche d'es composes pouvant assurer une bonne deionisation de l'eau, mais de structures telles qu'elles ne soient pas deteriorees par l'action de la temperature et des rayonnements. Nous nous sommes particulierement orientes dans trois voies: - echangeurs d'ions naturels a structure minerale (argile du type montmorillonite), - composes mineraux naturels traites pour leur conferer les proprietes d'echangeurs d'ions (charbons actives), - composes mineraux synthetiques (sels tres peu solubles, phosphate et hydroxyde de zirconium et de thorium). Dans ces etudes, nous nous sommes attaches a obtenir des produits stables en presence d'eau a haute temperature, tres insolubles et non
CFD modelling of hydrogen stratification in enclosures: Model validation and application to PAR performance

Energy Technology Data Exchange (ETDEWEB)

Hoyes, J.R., E-mail: james.hoyes@hsl.gsi.gov.uk; Ivings, M.J.

2016-12-15

Highlights: • The ability of CFD to predict hydrogen stratification phenomena is investigated. • Contrary to expectation, simulations on tetrahedral meshes under-predict mixing. • Simulations on structured meshes give good agreement with experimental data. • CFD model used to investigate the effects of stratification on PAR performance. • Results show stratification can have a significant effect on PAR performance. - Abstract: Computational Fluid Dynamics (CFD) models are maturing into useful tools for supporting safety analyses. This paper investigates the capabilities of CFD models for predicting hydrogen stratification in a containment vessel using data from the NEA/OECD SETH2 MISTRA experiments. Further simulations are then carried out to illustrate the qualitative effects of hydrogen stratification on the performance of Passive Autocatalytic Recombiner (PAR) units. The MISTRA experiments have well-defined initial and boundary conditions which makes them well suited for use in a validation study. Results are presented for the sensitivity to mesh resolution and mesh type. Whilst the predictions are shown to be largely insensitive to the mesh resolution they are surprisingly sensitive to the mesh type. In particular, tetrahedral meshes are found to induce small unphysical convection currents that result in molecular diffusion and turbulent mixing being under-predicted. This behaviour is not unique to the CFD model used here (ANSYS CFX) and furthermore, it may affect simulations run on other non-aligned meshes (meshes that are not aligned perpendicular to gravity), including non-aligned structured meshes. Following existing best practice guidelines can help to identify potential unphysical predictions, but as an additional precaution consideration should be given to using gravity-aligned meshes for modelling stratified flows. CFD simulations of hydrogen recombination in the Becker Technologies THAI facility are presented with high and low PAR positions
A Single-Cell Biochemistry Approach Reveals PAR Complex Dynamics during Cell Polarization.

Science.gov (United States)

Dickinson, Daniel J; Schwager, Francoise; Pintard, Lionel; Gotta, Monica; Goldstein, Bob

2017-08-21

Regulated protein-protein interactions are critical for cell signaling, differentiation, and development. For the study of dynamic regulation of protein interactions in vivo, there is a need for techniques that can yield time-resolved information and probe multiple protein binding partners simultaneously, using small amounts of starting material. Here we describe a single-cell protein interaction assay. Single-cell lysates are generated at defined time points and analyzed using single-molecule pull-down, yielding information about dynamic protein complex regulation in vivo. We established the utility of this approach by studying PAR polarity proteins, which mediate polarization of many animal cell types. We uncovered striking regulation of PAR complex composition and stoichiometry during Caenorhabditis elegans zygote polarization, which takes place in less than 20 min. PAR complex dynamics are linked to the cell cycle by Polo-like kinase 1 and govern the movement of PAR proteins to establish polarity. Our results demonstrate an approach to study dynamic biochemical events in vivo. Copyright © 2017 Elsevier Inc. All rights reserved.
The superoxide scavenger TEMPOL induces urokinase receptor (uPAR expression in human prostate cancer cells

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Francis Joseph

2006-06-01

Full Text Available Abstract There is little understanding of the effect that reactive oxygen metabolites have on cellular behavior during the processes of invasion and metastasis. These oxygen metabolites could interact with a number of targets modulating their function such as enzymes involved in basement membrane dissolution, adhesion molecules involved in motility or receptors involved in proliferation. We investigated the effect of increased scavenging of superoxide anions on the expression of the urokinase receptor (uPAR in PC-3M human prostate cancer cells. Urokinase receptor is a GPI-linked cell surface molecule which mediates multiple functions including adhesion, proliferation and pericellular proteolysis. Addition of the superoxide scavenger 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy (TEMPOL to PC-3M cultures stimulated expression of uPAR protein peaking between 48 and 72 hours. Cell surface expression of the uPAR was also increased. Surprisingly, uPAR transcript levels increased only slightly and this mild increase did not coincide with the striking degree of protein increase. This disparity indicates that the TEMPOL effect on uPAR occurs through a post-transcriptional mechanism. TEMPOL presence in PC-3M cultures reduced intracellular superoxide-type species by 75% as assayed by NBT dye conversion; however this reduction significantly diminished within hours following TEMPOL removal. The time gap between TEMPOL treatment and peak uPAR protein expression suggests that reduction of reactive oxygen metabolites in prostate cancer cells initiates a multistep pathway which requires several hours to culminate in uPAR induction. These findings reveal a novel pathway for uPAR regulation involving reactive oxygens such as superoxide anion.
Numerical analysis of the influence of PAR unit elevation within a vessel on its performance

International Nuclear Information System (INIS)

Kotouč, Miroslav

2011-01-01

On the basis of successful validation of the MELCOR code on several experiments from the international OECD/NEA programme THAI, a numerical parametric study has been conducted at NRI Řež evaluating the influence of PAR's vertical position within a vessel on its performance. Simulations were carried out for an Areva PAR unit which was considered to be placed at 5 different elevations in the THAI test vessel, the sixth simulation comprised a model of blower, simulating thus forced convection. The initial conditions were those of the THAI HR-12 test, which was characterized by steam-saturated atmosphere at elevated pressure and temperature. The results show that the overall hydrogen mass recombined monotonically decreases with PAR elevation. This behavior is due to hot, light and hydrogen-lean plume, coming out from the PAR outlet, which, due to buoyancy forces, eventually fills the upper part of the vessel and prevents thus the PAR unit from efficient operation (if the latter is placed near the top). It was also demonstrated that the effect of forced convection is favorable since it breaks the gas stratification and increases thus hydrogen concentration at the PAR inlet. (author)
Increased Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR Levels in Plasma of Suicide Attempters.

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Filip Ventorp

Full Text Available The soluble form of the urokinase receptor, suPAR, has been suggested as a novel biomarker of low-grade inflammation. Activation of the immune system has been proposed to contribute to the development of depression and suicidal behavior. In order to identify depressed and suicidal individuals who could benefit from an anti-inflammatory treatment, a reliable biomarker of low-grade inflammation is vital. This study evaluates plasma suPAR levels as a biomarker of low-grade inflammation in patients with major depressive disorder and in patients who recently attempted suicide. The plasma suPAR and an established biomarker, C reactive protein (CRP of suicide attempters (n = 54, depressed patients (n = 19 and healthy controls (n = 19 was analyzed with enzyme-linked immunosorbent assays. The biomarker attributes of sensitivity and sensibility were evaluated using ROC curve analysis. Both the depressed patients and suicide attempters had increased plasma suPAR. The levels of suPAR discriminated better between controls and suicide attempters than did CRP. In the future, plasma suPAR might be a superior prognosticator regarding outcome of treatment applying conventional antidepressants in conjunction with anti-inflammatory drugs.
A new class of medicament: radioactivity isotopes (1962); Une nouvelle classe de medicaments: les isotopes radioactifs (1962)

Energy Technology Data Exchange (ETDEWEB)

Cohen, Y. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1962-07-01

Very many radioelement are used in medicine, either for diagnosis or as therapeutics. The development of medicine has entailed an increase in the number of application of radioactive isotopes. Firstly used in the form of simple inorganic molecules for diagnosis or as anticancer therapeutics, radioelements are now used for labelling organic molecules, allowing functional specific studies of any kind of nature. Their production is made difficult by their radio-active properties. Their pharmaceutical properties, determined by tests and controls, depend either from radiochemistry and from medicine. The author reminds, in this report, the methods for the preparation and analysis, and set out the medical application. (author) [French] De tres nombreux radioelements trouvent une application en medecine humaine, soit dans le diagnostic, soit en therapeutique. L'evolution de la medecine entraine un accroissement du champ d'application des isotopes radioactifs. D'abord utilises sous forme de molecules minerales simples, pour les diagnostics ou des therapeutiques anticancereuses, les radioelements sont maintenant introduits dans des molecules organiques qui permettent des etudes fonctionnelles specifiques de toute nature. Leur fabrication est compliquee par leurs proprietes radioactives. Leurs caracteristiques pharmaceutiques determinees par des essais et controles, sont liees d'une part a la radiochimie, d'autre part a la medecine. L'auteur rappelle, dans cet expose, les methodes de preparation et d'analyse et aborde les applications medicales. (auteur)
A new class of medicament: radioactivity isotopes (1962); Une nouvelle classe de medicaments: les isotopes radioactifs (1962)

Energy Technology Data Exchange (ETDEWEB)

Cohen, Y [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1962-07-01

Very many radioelement are used in medicine, either for diagnosis or as therapeutics. The development of medicine has entailed an increase in the number of application of radioactive isotopes. Firstly used in the form of simple inorganic molecules for diagnosis or as anticancer therapeutics, radioelements are now used for labelling organic molecules, allowing functional specific studies of any kind of nature. Their production is made difficult by their radio-active properties. Their pharmaceutical properties, determined by tests and controls, depend either from radiochemistry and from medicine. The author reminds, in this report, the methods for the preparation and analysis, and set out the medical application. (author) [French] De tres nombreux radioelements trouvent une application en medecine humaine, soit dans le diagnostic, soit en therapeutique. L'evolution de la medecine entraine un accroissement du champ d'application des isotopes radioactifs. D'abord utilises sous forme de molecules minerales simples, pour les diagnostics ou des therapeutiques anticancereuses, les radioelements sont maintenant introduits dans des molecules organiques qui permettent des etudes fonctionnelles specifiques de toute nature. Leur fabrication est compliquee par leurs proprietes radioactives. Leurs caracteristiques pharmaceutiques determinees par des essais et controles, sont liees d'une part a la radiochimie, d'autre part a la medecine. L'auteur rappelle, dans cet expose, les methodes de preparation et d'analyse et aborde les applications medicales. (auteur)
Pars plana vitrectomy for disturbing primary vitreous floaters: clinical outcome and patient satisfaction

NARCIS (Netherlands)

Nie, K.F. de; Crama, N.; Tilanus, M.A.D.; Klevering, B.J.; Boon, C.J.F.

2013-01-01

BACKGROUND: Primary vitreous floaters can be highly bothersome in some patients. In the case of persistently bothersome floaters, pars plana vitrectomy may be the most effective treatment. The aim of this study is to evaluate the incidence of complications, and patient satisfaction, after pars plana
Active zone proteins are transported via distinct mechanisms regulated by Par-1 kinase.

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Kara R Barber

2017-02-01

Full Text Available Disruption of synapses underlies a plethora of neurodevelopmental and neurodegenerative disease. Presynaptic specialization called the active zone plays a critical role in the communication with postsynaptic neuron. While the role of many proteins at the active zones in synaptic communication is relatively well studied, very little is known about how these proteins are transported to the synapses. For example, are there distinct mechanisms for the transport of active zone components or are they all transported in the same transport vesicle? Is active zone protein transport regulated? In this report we show that overexpression of Par-1/MARK kinase, a protein whose misregulation has been implicated in Autism spectrum disorders (ASDs and neurodegenerative disorders, lead to a specific block in the transport of an active zone protein component- Bruchpilot at Drosophila neuromuscular junctions. Consistent with a block in axonal transport, we find a decrease in number of active zones and reduced neurotransmission in flies overexpressing Par-1 kinase. Interestingly, we find that Par-1 acts independently of Tau-one of the most well studied substrates of Par-1, revealing a presynaptic function for Par-1 that is independent of Tau. Thus, our study strongly suggests that there are distinct mechanisms that transport components of active zones and that they are tightly regulated.
Power calibration of Proserpine (1960); Etalonnage en puissance de proserpine (1960)

Energy Technology Data Exchange (ETDEWEB)

Clouet d' Orval, C; Deilgat, E; Guery, M [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

1960-07-01

The power of a homogeneous reactor can be determined if the fission rate at one point is known, and also the flux chart throughout the whole volume of fuel. By applying this method to Proserpine, the following operations have been carried out: 1) determination of the fission rate at a point by means of a miniature zirconium fission chamber, with absolute counting of the plutonium deposit in a low-geometry {alpha} chamber; 2)establishment of a flux chart by activation of gold bands, without contamination of gold by plutonium. (author) [French] On peut determiner la puissance d'un reacteur homogene si l'on connait le taux des reactions de fission en un point, et la carte du flux dans tout le volume du combustible. Cette methode, appliquee a la pile Proserpine, a conduit aux manipulations suivantes: 1) determination du taux de reactions en un point, grace a une chambre a fission miniature en zirconium, dont le depot de plutonium a fait l'objet de comptages absolus dans une chambre {alpha} a faible geometrie; 2) etablissement d'une carte de flux, par activation de bandes d'or, sans contamination de l'or par le plutonium. (auteur)
Localization of amylin-like immunoreactivity in melanocyte-stimulating hormone-containing cells of the pars intermedia but not those of the pars distalis in the axolotl (Ambystoma mexicanum) pituitary.

Science.gov (United States)

Suzuki, Hirohumi; Yamamoto, Toshiharu

2016-04-01

Immunohistochemical techniques were employed to investigate the distribution of amylin-like immunoreactivity in the axolotl (Ambystoma mexicanum) pituitary. Amylin-immunoreactive cells were observed in the pars intermedia, and these cells were found to be immunoreactive for α-melanocyte-stimulating hormone (αMSH) as well. In contrast, αMSH-immunoreactive cells in the pars distalis were immuno-negaitive for amylin. These light microscopic findings were confirmed by immunoelectron microscopy. Amylin-immunoreactive signals were located on the haloes of presumable secretory granules in association with αMSH-immunoreactive signals in the amylin-positive cells. However, in the pars distalis, the αMSH-positive cells did not contain amylin-immunoreactive secretory granules. Western blot analysis of axolotl pituitary extracts revealed the labeling of a protein band at approximately 10.5-kDa by the anti-rat amylin serum, which was not labeled by the anti-αMSH antibody. These findings indicate that amylin secreted from MSH-producing cells in the pars intermedia may modulate MSH secretion in an autocrine fashion and may participate in MSH functions such as fatty homeostasis together with MSH. Copyright © 2016 Elsevier GmbH. All rights reserved.
evaluation de la fertilite femelle des arabusta par le niveau de ...

African Journals Online (AJOL)

Les hybrides Arabusta sont caractérisés par une faible fertilité exprimée par des taux de caracolis élevés et des taux de loges vides importants induisant des productivités faibles. Pour une stratégie plus efficiente des sélections, il est important de connaître les niveaux de fertilité femelle des différents types de caféiers ...
Slow Neutron Spectrometers at the Swedish Reactors; Spectrometres a Neutrons Lents des Reacteurs Suedois; 0421 041f 0415 041a 0422 0420 041e 041c 0415 0422 0420 042b 041c 0415 0414 041b 0415 041d 041d 042b 0425 041d 0415 0419 0422 0420 041e 041d 041e 0412 041d 0410 0428 0412 0415 0414 0421 041a 0418 0425 0420 0415 0410 041a 0422 041e 0420 0410 0425 ; Espectrometros para Neutrones Lentos en los Reactores de Suecia

Energy Technology Data Exchange (ETDEWEB)

Dahlborg, U.; Skoeld, K. [AB Atomenergi, Stockholm (Sweden); Larsson, K. -E. [Royal Institute of Technology, Stockholm (Sweden)

1965-06-15

faible du pouvoir de resolution entraine une perte d'intensite importante. Il est interessant de noter qu'en comparant les reacteurs RI et R2 en tant que sources de neutrons pour les travaux dans les canaux, on constate qu'a la sortie des neutrons, le flux cent'fois superieur de R2 subit des pertes correspondant a un facteur de dix environ. Ce phenomene s'explique par le faible diametre des canaux et par la necessite d'employer des filtres pour reduire les flux de neutrons rapides et de rayons gamma. A titre d'exemple, les auteurs discutent brievement quelques donnees sur H{sub 2}O obtenues par diffusion a l'aide des divers instruments. Une comparaison entre reacteurs a eau legere et reacteurs a eau lourde montre que pour les travaux dans les canaux les reacteurs a eau lourde presentent des avantages certains. (author) [Spanish] En los dos reactores de investigacion suecos, el RI de Estocolmo y el R2 de Studsvik, se da actualmente la posibilidad de utilizar cuatro diferentes espectrometros neutronicos para llevar a cabo experimentos de dispersion inelastica. En el reactor R1 de Estocolmo, de 600 kW y moderado por agua pesada, funcionan simultaneamente dos espectrometros de tiempo de vuelo con selectores de neutrones lentos. En uno de ellos se emplea permanentemente un filtro de Be en calidad de monocromador, mientras que en el otro se puede utilizar este filtro o un mono- cromador de cristal. Se ha comprobado que las mediciones de la distribucion angular en las que se combina un monocromador de cristal y un analizador de tiempo de vuelo dan resultados muy utiles, aunque tanto la intensidad como la resolucion obtenidas son relativamente bajas. Recientemente se ha ensayado un selector mecanico de velocidad con un poder de resolucion de 4,2% referido a la longitud de onda, pero el instrumento no se emplea todavia en los experimentos. El espectrometro de tiempo de vuelo de Studsvik, instalado en el reactor R2, de 30 MW moderado por agua ligera, emplea como monocromador el
MMP-1/PAR-1 signal transduction axis and its prognostic impact in esophageal squamous cell carcinoma

Directory of Open Access Journals (Sweden)

Hong-hua Peng

2012-01-01

Full Text Available The matrix metalloprotease-1 (MMP-1/protease-activated receptor-1 (PAR-1 signal transduction axis plays an important role in tumorigenesis. To explore the expression and prognostic value of MMP-1 and PAR-1 in esophageal squamous cell carcinoma (ESCC, we evaluated the expression of two proteins in resected specimens from 85 patients with ESCC by immunohistochemistry. Sixty-two (72.9% and 58 (68.2% tumors were MMP-1- and PAR-1-positive, respectively, while no significant staining was observed in normal esophageal squamous epithelium. MMP-1 and PAR-1 overexpression was significantly associated with tumor node metastasis (TNM stage and regional lymph node involvement. Patients with MMP-1- and PAR-1-positive tumors, respectively, had poorer disease-free survival (DFS than those with negative ESCC (P = 0.002 and 0.003, respectively. Univariate analysis showed a significant relationship between TNM stage [hazard ratio (HR = 2.836, 95% confidence interval (CI = 1.866-4.308], regional lymph node involvement (HR = 2.955, 95%CI = 1.713-5.068, MMP-1 expression (HR = 2.669, 95%CI = 1.229-6.127, and PAR-1 expression (HR = 1.762, 95%CI = 1.156-2.883 and DFS. Multivariate analysis including the above four parameters identified TNM stage (HR = 2.035, 95%CI = 1.167-3.681, MMP-1 expression (HR = 2.109, 95%CI = 1.293-3.279, and PAR-1 expression (HR = 1.967, 95%CI = 1.256-2.881 as independent and significant prognostic factors for DFS. Our data suggest for the first time that MMP-1 and PAR-1 were both overexpressed in ESCC and are novel predictors of poor patient prognosis after curative resection. The MMP-1/PAR-1 signal transduction axis might be a new therapeutic target for future therapies tailored against ESCC.
MMP-1/PAR-1 signal transduction axis and its prognostic impact in esophageal squamous cell carcinoma

Energy Technology Data Exchange (ETDEWEB)

Peng, Hong-hua; Zhang, Xi; Cao, Pei-guo [Department of Oncology, the Third Xiangya Hospital, Central South University, Changsha, Hunan Province (China)

2011-11-18

The matrix metalloprotease-1 (MMP-1)/protease-activated receptor-1 (PAR-1) signal transduction axis plays an important role in tumorigenesis. To explore the expression and prognostic value of MMP-1 and PAR-1 in esophageal squamous cell carcinoma (ESCC), we evaluated the expression of two proteins in resected specimens from 85 patients with ESCC by immunohistochemistry. Sixty-two (72.9%) and 58 (68.2%) tumors were MMP-1- and PAR-1-positive, respectively, while no significant staining was observed in normal esophageal squamous epithelium. MMP-1 and PAR-1 overexpression was significantly associated with tumor node metastasis (TNM) stage and regional lymph node involvement. Patients with MMP-1- and PAR-1-positive tumors, respectively, had poorer disease-free survival (DFS) than those with negative ESCC (P = 0.002 and 0.003, respectively). Univariate analysis showed a significant relationship between TNM stage [hazard ratio (HR) = 2.836, 95% confidence interval (CI) = 1.866-4.308], regional lymph node involvement (HR = 2.955, 95%CI = 1.713-5.068), MMP-1 expression (HR = 2.669, 95%CI = 1.229-6.127), and PAR-1 expression (HR = 1.762, 95%CI = 1.156-2.883) and DFS. Multivariate analysis including the above four parameters identified TNM stage (HR = 2.035, 95%CI = 1.167-3.681), MMP-1 expression (HR = 2.109, 95%CI = 1.293-3.279), and PAR-1 expression (HR = 1.967, 95%CI = 1.256-2.881) as independent and significant prognostic factors for DFS. Our data suggest for the first time that MMP-1 and PAR-1 were both overexpressed in ESCC and are novel predictors of poor patient prognosis after curative resection. The MMP-1/PAR-1 signal transduction axis might be a new therapeutic target for future therapies tailored against ESCC.
Radiological findings and healing patterns of incomplete stress fractures of the pars interarticularis

International Nuclear Information System (INIS)

Dunn, Andrew J.; Campbell, Robert S.D.; Mayor, Peter E.; Rees, Dai

2008-01-01

The objective was to retrospectively record the CT and MRI features and healing patterns of acute, incomplete stress fractures of the pars interarticularis. The CT scans of 156 adolescents referred with suspected pars interarticularis stress fractures were reviewed. Patients with incomplete (grade 2) pars fractures were included in the study. Fractures were assessed on CT according to vertebral level, location of cortical involvement and direction of fracture propagation. MRI was also performed in 72 of the 156 cases. MRI images of incomplete fractures were assessed for the presence of marrow oedema and cortical integrity. Fracture healing patterns were characterised on follow-up CT imaging. Twenty-five incomplete fractures were identified in 23 patients on CT. All fractures involved the inferior or infero-medial cortex of the pars and propagated superiorly or superolaterally. Ninety-two percent of incomplete fractures demonstrated either complete or partial healing on follow-up imaging. Two (8%) cases progressed to complete fractures. Thirteen incomplete fractures in 11 patients confirmed on CT also had MRI, and 92% demonstrated oedema in the pars. Ten out of thirteen fractures (77%) showed a break in the infero-medial cortex with intact supero-lateral cortex, which correlated with the CT findings. MRI incorrectly graded one case as a complete (grade 3) fracture, and 2 cases as (grade 1) stress reaction. Six fractures had follow-up MRI, 67% showed partial or complete cortical healing, and the same number showed persistent marrow oedema. Incomplete fracture of the pars interarticularis represents a stage of the evolution of a complete stress fracture. The direction of fracture propagation is consistent, and complete healing can be achieved in most cases with appropriate clinical management. CT best demonstrates fracture size and extent, and is the most appropriate modality for follow-up. MRI is limited in its ability to fully depict the cortical integrity of

Radiological findings and healing patterns of incomplete stress fractures of the pars interarticularis

Energy Technology Data Exchange (ETDEWEB)

Dunn, Andrew J.; Campbell, Robert S.D. [Royal Liverpool and Broadgreen University Teaching Hospitals, Department of Medical Imaging, Liverpool (United Kingdom); Mayor, Peter E. [Leighton Hospital, Department of Medical Imaging, Crewe, Cheshire (United Kingdom); Rees, Dai [Robert Jones and Agnes-Hunt Orthopaedic Hospital, Department of Orthopaedic Surgery, Oswestry, Shropshire (United Kingdom)

2008-05-15

The objective was to retrospectively record the CT and MRI features and healing patterns of acute, incomplete stress fractures of the pars interarticularis. The CT scans of 156 adolescents referred with suspected pars interarticularis stress fractures were reviewed. Patients with incomplete (grade 2) pars fractures were included in the study. Fractures were assessed on CT according to vertebral level, location of cortical involvement and direction of fracture propagation. MRI was also performed in 72 of the 156 cases. MRI images of incomplete fractures were assessed for the presence of marrow oedema and cortical integrity. Fracture healing patterns were characterised on follow-up CT imaging. Twenty-five incomplete fractures were identified in 23 patients on CT. All fractures involved the inferior or infero-medial cortex of the pars and propagated superiorly or superolaterally. Ninety-two percent of incomplete fractures demonstrated either complete or partial healing on follow-up imaging. Two (8%) cases progressed to complete fractures. Thirteen incomplete fractures in 11 patients confirmed on CT also had MRI, and 92% demonstrated oedema in the pars. Ten out of thirteen fractures (77%) showed a break in the infero-medial cortex with intact supero-lateral cortex, which correlated with the CT findings. MRI incorrectly graded one case as a complete (grade 3) fracture, and 2 cases as (grade 1) stress reaction. Six fractures had follow-up MRI, 67% showed partial or complete cortical healing, and the same number showed persistent marrow oedema. Incomplete fracture of the pars interarticularis represents a stage of the evolution of a complete stress fracture. The direction of fracture propagation is consistent, and complete healing can be achieved in most cases with appropriate clinical management. CT best demonstrates fracture size and extent, and is the most appropriate modality for follow-up. MRI is limited in its ability to fully depict the cortical integrity of
Equações de chuvas intensas para o estado do Pará Intense rainfall equations for the state of Pará, Brazil

Directory of Open Access Journals (Sweden)

Rodrigo O. R. de M. Souza

2012-09-01

Full Text Available As equações de chuvas intensas têm sido usadas como ferramenta importante para o dimensionamento de obras hidráulicas. Devido à grande carência de informações relativas às equações de chuvas intensas, o presente trabalho teve como objetivo a obtenção das relações de intensidade, duração e frequência de precipitação pluvial para o Estado do Pará, utilizando-se a metodologia da desagregação da chuva de 24 h. Foram utilizadas séries históricas de dados pluviométricos de 74 cidades do Estado do Pará, obtidas no Sistema de Informações Hidrológicas da Agência Nacional de Águas-ANA. As equações de intensidade-duração-frequência foram devidamente ajustadas e apresentaram bom ajuste, com coeficientes de determinação acima de 0,99. A maioria das estações (51,4% apresentou intensidade de precipitação entre 90 e 110 mm h-1, para uma duração de chuva de 30 min e um tempo de retorno de 15 anos. Pode-se perceber uma concentração das maiores precipitações na região próxima ao litoral do nordeste paraense e no sudeste da Ilha do Marajó.The intense rainfall equations have been used as an important tool for design of hydraulic structures. Considering the lack of intense rainfall equations, this study aimed to determine the relations of intensity, duration and frequency of intense rainfall in the Pará State (Brazil, using the one-day rain disaggregation method. In this research rainfall data of 74 cities in the State of Pará were used, obtained from the Hydrological Information System of the National Water Agency-ANA. The equations of intensity-duration-frequency were adjusted and presented good adjustment with coefficients of determination above 0.99. Most stations (51.4% showed intensity of precipitation between 90 and 110 mm h-1 for duration of 30 min and rainfall return period of 15 years. The highest rainfall intensities were in the region near the northeast coast of Pará State and southeast of the Marajo
Plant-derived SAC domain of PAR-4 (Prostate Apoptosis Response 4 exhibits growth inhibitory effects in prostate cancer cells

Directory of Open Access Journals (Sweden)

Shayan eSarkar

2015-10-01

Full Text Available The gene Par-4 (Prostate Apoptosis Response 4 was originally identified in prostate cancer cells undergoing apoptosis and its product Par-4 showed cancer specific pro-apoptotic activity. Particularly, the SAC domain of Par-4 (SAC-Par-4 selectively kills cancer cells leaving normal cells unaffected. The therapeutic significance of bioactive SAC-Par-4 is enormous in cancer biology; however, its large scale production is still a matter of concern. Here we report the production of SAC-Par-4-GFP fusion protein coupled to translational enhancer sequence (5′ AMV and apoplast signal peptide (aTP in transgenic Nicotiana tabacum cv. Samsun NN plants under the control of a unique recombinant promoter M24. Transgene integration was confirmed by genomic DNA PCR, Southern and Northern blotting, Real-time PCR and Nuclear run-on assays. Results of Western blot analysis and ELISA confirmed expression of recombinant SAC-Par-4-GFP protein and it was as high as 0.15% of total soluble protein. In addition, we found that targeting of plant recombinant SAC-Par-4-GFP to the apoplast and endoplasmic reticulum (ER was essential for the stability of plant recombinant protein in comparison to the bacterial derived SAC-Par-4. Deglycosylation analysis demonstrated that ER-targeted SAC-Par-4-GFP-SEKDEL undergoes O-linked glycosylation unlike apoplast-targeted SAC-Par-4-GFP. Furthermore, various in vitro studies like mammalian cells proliferation assay (MTT, apoptosis induction assays, and NF-κB suppression suggested the cytotoxic and apoptotic properties of plant-derived SAC-Par-4-GFP against multiple prostate cancer cell lines. Additionally, pre-treatment of MAT-LyLu prostate cancer cells with purified SAC-Par-4-GFP significantly delayed the onset of tumor in a syngeneic rat prostate cancer model. Taken altogether, we proclaim that plant made SAC-Par-4 may become a useful alternate therapy for effectively alleviating cancer in the new era.
Contribution to the study of can deformations in the fuel elements of gas-graphite reactors during thermal cycling; Contribution a l'etude des deformations des gaines des elements combustibles de reacteur graphite-gaz au cours du cyclage thermique

Energy Technology Data Exchange (ETDEWEB)

Gauthron, M; Boudouresques, B; Delpeyroux, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

The cans of fuel cartridges used in reactors of the gas-graphite type have either longitudinal fins of variable thickness, short herring-bone fins, or else a mixture of the two. An important test of the strength of these cartridges is their behaviour during thermal cycling carried out in cells reproducing in-pile conditions. It has been observed during with rapid cooling that there occurs a shortening at the base of the fins which can be accompanied in particular by a compression effect at the fin type, which has a tendency to curl, and by a tractive force acting on the body of the can at the ends of the longitudinal fins; this last phenomenon can result in a fracturing of the welds at the extremities or of the ends of the cartridge. This report presents first of all the way in which the stress diagram can be drawn for a can touching the fuel, and then the effect of the ratchet along a fin fixed to a bar with or without grooves. Finally the importance is shown of the test cycling variables (temperature, heating and cooling rates). (authors) [French] Les gaines des cartouches combustibles des reacteurs de la filiere graphite-gaz comportent soit des ailettes longitudinales plus ou moins epaisses, soit de courtes ailettes a chevrons, soit un ensemble des deux. Un test important de la tenue des cartouches, est la tenue au cyclage thermique en cellule pour reproduire le comportement en pile. On a observe au cours des cyclages a refroidissement rapide, un raccourcissement a la base des ailettes qui peut s'accompagner notamment d'une mise en compression du sommet de l'ailette qui a tendance a friser, et d'une traction exercee sur le corps des gaines au bout des ailettes longitudinales; ce dernier phenomene peut se traduire par des ruptures de soudures d'extremites ou des parties terminales de la cartouche. Ce rapport presente d'abord la maniere dont peut etre trace le diagramme des contraintes dans une gaine liee au combustible, puis l'effet du rochet le long d
Fast flux measurements by means of threshold detectors on the reactor 'Melusine'; Mesures de flux rapides a l'aide de detecteurs a seuil sur le reacteur 'Melusine'

Energy Technology Data Exchange (ETDEWEB)

Leger, P; Sautiez, B [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

1959-07-01

Using existing data on the (n,p) and (n,{alpha}) threshold reactions we have carried out fast flux measurements on the swimming pool type reactor 'Melusine'. Four common elements: P, S, Mg, Al were chosen because from the point of view of fast spectrum analysis they represent a fairly good energy range from 2.4 MeV to 8 MeV. The fission flux value found in the central element at a power of 1 MW is 1.4 x 10{sup 13} n/cm{sup 2}/s {+-} 0.14. (author) [French] A l'aide des donnees actuelles sur les reactions a seuil (n,p) et (n,{alpha}) nous avons realise des mesures de flux rapide dans le reacteur du type piscine 'Melusine'. Quatre corps courants: P, S, Mg, Al, ont ete choisis parce qu'ils constituent au point de vue de l'analyse du spectre rapide un assez bon etalement en energie de 2,4 MeV A 8 MeV. La valeur du flux de fission trouve dans l'element central a une puissance de 1 MW est de 1,4.10{sup 13} n/cm{sup 2}/s {+-} 0,14. (auteur)
Hep par-1: a novel immunohistochemical marker for differentiating hepatocellular carcinoma from metastatic carcinoma

International Nuclear Information System (INIS)

Hanif, R.

2014-01-01

To evaluate the diagnostic utility of Hep par-1 in differentiating hepatocellular carcinoma from metastatic carcinoma taking histopathology as a gold standard. Study Design: Comparative cross-sectional study. Place and Duration of Study: Pathology Department, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, from April 2007 to February 2008. Methodology: Hep par-1 immunohistochemical stain was performed on 60 cases of liver carcinoma, 30 cases each of metastatic and hepatocellular carcinoma. Information regarding patient age, gender, sign and symptoms, radiographic findings, histological grade of tumour, and expression of Hep par-1 on hepatocellular and metastatic carcinoma were recorded on proforma sheet. Sensitivity, specificity, positive and negative predictive values, and accuracy of Hep par-1 were calculated using the formulas. Results: Hep par-1 expression was noted in 25 out of 30 cases of hepatocellular carcinoma (83%). Out of 30 cases of metastatic carcinoma, only one case expressed staining in < 5% tumour cells and remaining 29 cases showed no reactivity. The age of the patients with hepatocellular carcinoma ranged from 40 to 76 years with a median age of 60.5 years and 40 - 75 years for metastatic carcinomas with a median age of 57.5 years. Conclusion: Hep par-1 is a reliable immunohistochemical marker for cases of hepatocellular carcinoma (HCC). It can be used along with other markers in morphologically difficult cases when differential diagnosis lies between poorly differentiated HCC and metastatic carcinoma of liver. (author)
Paraplégie compliquant une plaie abdominale antérieure par arme blanche

Science.gov (United States)

Elahmadi, Brahim; Awab, Almahdi; El Moussaoui, Rachid; El Hijri, Ahmed; Azzouzi, Abderrahim; Alilou, Mustapha

2015-01-01

Les traumatismes médullaires sont des complications rares des plaies abdominales antérieures par arme blanche. Son diagnostic est difficile parfois retardé. L'imagerie par résonance magnétique reste l'examen de choix. Le traitement dépend du tableau clinique et de la gravité de la souffrance médullaire. Le pronostic est corrélé à l’étendue et à la nature de la lésion médullaire. Nous rapportons un cas exceptionnel d'un traumatisme médullaire chez une patiente victime d'une plaie abdominale antérieure par arme blanche. PMID:25995808
In vitro activity of five quinolones and analysis of the quinolone resistance-determining regions of gyrA, gyrB, parC, and parE in Ureaplasma parvum and Ureaplasma urealyticum clinical isolates from perinatal patients in Japan.

Science.gov (United States)

Kawai, Yasuhiro; Nakura, Yukiko; Wakimoto, Tetsu; Nomiyama, Makoto; Tokuda, Tsugumichi; Takayanagi, Toshimitsu; Shiraishi, Jun; Wasada, Kenshi; Kitajima, Hiroyuki; Fujita, Tomio; Nakayama, Masahiro; Mitsuda, Nobuaki; Nakanishi, Isao; Takeuchi, Makoto; Yanagihara, Itaru

2015-04-01

Ureaplasma spp. cause several disorders, such as nongonococcal urethritis, miscarriage, and preterm delivery with lung infections in neonates, characterized by pathological chorioamnionitis in the placenta. Although reports on antibiotic resistance in Ureaplasma are on the rise, reports on quinolone-resistant Ureaplasma infections in Japan are limited. The purpose of this study was to determine susceptibilities to five quinolones of Ureaplasma urealyticum and Ureaplasma parvum isolated from perinatal samples in Japan and to characterize the quinolone resistance-determining regions in the gyrA, gyrB, parC, and parE genes. Out of 28 clinical Ureaplasma strains, we isolated 9 with high MICs of quinolones and found a single parC gene mutation, resulting in the change S83L. Among 158 samples, the ParC S83L mutation was found in 37 samples (23.4%), including 1 sample harboring a ParC S83L-GyrB P462S double mutant. Novel mutations of ureaplasmal ParC (S83W and S84P) were independently found in one of the samples. Homology modeling of the ParC S83W mutant suggested steric hindrance of the quinolone-binding pocket (QBP), and de novo prediction of peptide structures revealed that the ParC S84P may break/kink the formation of the α4 helix in the QBP. Further investigations are required to unravel the extent and mechanism of antibiotic resistance of Ureaplasma spp. in Japan. Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Etude par imagerie radar des pollutions pétrolières

Directory of Open Access Journals (Sweden)

G. Rees

2004-06-01

Full Text Available En Russie, chaque année, les déversements de pétrole représentent un cinquième de la production totale. Les plus importants se produisent dans le domaine périglaciaire où le milieu naturel est d’une extrême fragilité. Les pipelines sont soumis à de rudes conditions notamment à la corrosion et aux processus cryogéniques. Le risque de rupture augmente en conséquence. La surveillance des déversements d’hydrocarbures, contrainte par l’immensité et la fréquente inaccessibilité du réseau de pipelines, peut être réalisée par le recours à la télédétection. L’objectif de ce travail est de fournir, à travers l’exemple de la catastrophe d’Usinsk (Rép. de Komi survenue en 1994, des outils d’analyse des images radar. Outre leur capacité à s’affranchir du couvert nuageux, les capteurs radar apportent des informations complémentaires à celles fournies par des capteurs optiques. L’exploitation thématique de ces images est rendue difficile par un certain nombre de facteurs perturbateurs tels que les caractéristiques propres du capteur, la direction de visée, la topographie et le phénomène de chatoiement (speckle. Le travail présenté montre le rôle prépondérant joué par ces corrections qui permettent de disposer de données quantitatives comparables d’une date à une autre. La méthode mise au point ici pour le suivi temporel de l’épanchement de pétrole d’Usinsk à partir de trois images radar, est discutée notamment dans ses limites et son aspect opérationnel possible.
Increased plasma soluble uPAR level is a risk marker of respiratory cancer in initially cancer-free individuals

DEFF Research Database (Denmark)

Langkilde, Anne A; Hansen, Tine Willum; Ladelund, Steen

2011-01-01

BACKGROUND: Soluble urokinase plasminogen activator receptor (suPAR) is a stable plasma biomarker associated with inflammation and disease. This study tested the association between suPAR levels and incident respiratory, gastrointestinal or other types of cancer in initially cancer-free individuals...... with respiratory, gastrointestinal and other cancer types, respectively.CONCLUSIONS: Elevated suPAR levels were associated with increased risk of incident respiratory cancer and other types of cancer, but not gastrointestinal cancers, independently of established risk factors, CRP and leukocyte numbers. Impact.......RESULTS: suPAR levels ranged from 0.6-22 ng/ml, and median suPAR level was 4.01 ng/ml. 1 ng/ml increase in baseline suPAR was associated with adjusted hazard ratios (HR) of 1.61 (95% CI: 1.23-2.11, P
Experimental studies of some of the physical features of beryllium-moderated intermediate reactors; Etude experimentale de quelques particularites physiques des reacteurs a neutrons intermediaires, ralentis au beryllium; Ehksperimental'ny e issledovaniya nekotorykh fizicheskikh osobennostej promezhutochnykh reaktorov s berillievym zamedlitelem; Estudios experimentales de algunas caracteristicas fisicas de los reactores intermedios moderados con berilio

Energy Technology Data Exchange (ETDEWEB)

Lejpunskij, A I; Kuznetsov, V A; Artyukhov, G Ya; Mogil' ner, A I; Prokhorov, Yu A; Steklovski, V M; Chernov, L A [Akademiya Nauk, Moskva, Union of Soviet Socialist Republics (Russian Federation)

1962-03-15

of neutrons absorbed by the uranium. The paper provides data, derived from the same assembly, on the efficiency of rods made of various absorbing materials. It gives the experimentally measured distribution of neutron density for neutrons of various energies in the neighbourhood of a boron-carbide rod, and the density of neutron captures by a 1/v detector within the rod. The paper also discusses methods used and the results obtained from experiments designed to assess the efficiency of recompensation, cylinders placed on the boundary between core and reflector. (author) [French] Le memoire analyse les resultats de plusieurs experiences effectuees sur l'ensemble critique PF-4, qui est destine a l'etude detaillee des particularites physiques des reacteurs a neutrons intermediaires. Les coeurs et les reflecteurs des differents esembles critiques etaient constitues par un assemblage compact de tubes en acier ou en aluminium dans lesquels etaient inseres des diques de diverses matieres. En combinant selon differentes proportions les disques d'uranium enrichi a 90% et les matieres de ralentissement et en introduisant dans le reflecteur des couches de ralentisseur de diverses epaisseurs, on a pu obtenir de grandes modifications du spectre des neutrons provoquant la fission. Le memoire decrit l'ensemble critique PF-4 et les differents assemblages qui le composent. Les auteurs analysent l'efficacite relative du ralentissement interieur et exterieur pour des reacteurs dans lesquels le rapport noyaux du ralentisseur noyaux d'uranium dans le coeur est tres peu eleve. Il ressort des experiences que, meme lorsqu'on emploie des reflecteurs tres epais, la faible dilution de l'uranium par le ralentisseur (le rap- port entre les noyaux du beryllium et de l'uranium-235 etant: {partial_derivative}Be/{partial_derivative}{sup 235}U{approx_equal}1) entraine un accroissement de la masse critique. Une partie importante du memoire est consacree a une analyse des effets hetero- genes produits
Lambeaux autofermants pour le traitement des brulures electriques du scalp par haut voltage

Science.gov (United States)

Hafidi, J.; El Mazouz, S.; El Mejatti, H.; Fejjal, N.; Gharib, N.E.; Abbassi, A.; Belmahi, A.M.

2011-01-01

Summary Les brûlures électriques par haut voltage sont responsables de gros dégâts tissulaires en immédiat et dans les jours suivant l’accident du fait de la chaleur importante dégagée par effet joule et de la thrombose microvasculaire évolutive. Les pertes de substances du scalp secondaires à ces brûlures nécessitent une couverture par lambeaux vu la destruction du périoste et du calvarium en regard. De juin 1997 à juin 2008, 15 patients ont été traités pour des pertes de substance du scalp secondaires à des brûlures électriques par haut voltage de diamètre allant de 8 à 11 cm et siégeant dans la région tonsurale. Ces patients ont été opérés dans la première semaine suivant l’accident. Les pertes de substance du scalp de taille moyenne secondaires à ces brûlures peuvent être couvertes per primam de façon fiable par des lambeaux locaux axialisés et multiples. Nous relatons l’expérience du Service de Chirurgie Plastique du Centre Hospitalier Universitaire Ibn-Sina, Rabat, Maroc, dans la gestion et la prise en charge de ces brûlures. PMID:22262963
Spondylolysis outcomes in adolescents after direct screw repair of the pars interarticularis.

Science.gov (United States)

Snyder, Laura A; Shufflebarger, Harry; O'Brien, Michael F; Thind, Harjot; Theodore, Nicholas; Kakarla, Udaya K

2014-09-01

Isthmic spondylolysis can significantly decrease functional abilities, especially in adolescent athletes. Although treatment can range from observation to surgery, direct screw placement through the fractured pars, or Buck's procedure, may be a more minimally invasive procedure than the more common pedicle screw-hook construct. Review of surgical databases identified 16 consecutive patients treated with Buck's procedure from 2004 to 2010. Twelve patients were treated at Miami Children's Hospital and 4 at Barrow Neurological Institute. Demographics and clinical and radiographic outcomes were recorded and analyzed retrospectively. The 16 patients had a median age of 16 years, and 14 were 20 years or younger at the time of treatment. Symptoms included axial back pain in 100% of patients with concomitant radiculopathy in 38%. Pars defects were bilateral in 81% and unilateral in 19% for a total of 29 pars defects treated using Buck's procedure. Autograft or allograft augmented with recombinant human bone morphogenetic protein as well as postoperative bracing was used in all cases. Postoperatively, symptoms resolved completely or partially in 15 patients (94%). Of 29 pars defects, healing was observed in 26 (89.6%) prior to 1 revision surgery, and an overall fusion rate of 97% was observed at last radiological follow-up. There were no implant failures. All 8 athletes in this group had returned to play at last follow-up. Direct screw repair of the pars interarticularis defect as described in this series may provide a more minimally invasive treatment of adolescent patients with satisfactory clinical and radiological outcomes, including return to play of adolescent athletes.
Compression robuste du signal par la transformée avec les B ...

African Journals Online (AJOL)

Par contre, elle diminue de façon considérable pour les b-splincs et les paquets dbndelcttes de Haar. Du point de vue entropie, la compression par bfsplines est bonne que celle de la TCD. Nous donnons ci-dessous un tableau récapitulatif des résultats de quelques méthodes utilisées pour deux signaux EMG. Le facteur de ...
Planar Cell Polarity Breaks the Symmetry of PAR Protein Distribution prior to Mitosis in Drosophila Sensory Organ Precursor Cells.

Science.gov (United States)

Besson, Charlotte; Bernard, Fred; Corson, Francis; Rouault, Hervé; Reynaud, Elodie; Keder, Alyona; Mazouni, Khalil; Schweisguth, François

2015-04-20

During development, cell-fate diversity can result from the unequal segregation of fate determinants at mitosis. Polarization of the mother cell is essential for asymmetric cell division (ACD). It often involves the formation of a cortical domain containing the PAR complex proteins Par3, Par6, and atypical protein kinase C (aPKC). In the fly notum, sensory organ precursor cells (SOPs) divide asymmetrically within the plane of the epithelium and along the body axis to generate two distinct cells. Fate asymmetry depends on the asymmetric localization of the PAR complex. In the absence of planar cell polarity (PCP), SOPs divide with a random planar orientation but still asymmetrically, showing that PCP is dispensable for PAR asymmetry at mitosis. To study when and how the PAR complex localizes asymmetrically, we have used a quantitative imaging approach to measure the planar polarization of the proteins Bazooka (Baz, fly Par3), Par6, and aPKC in living pupae. By using imaging of functional GFP-tagged proteins with image processing and computational modeling, we find that Baz, Par6, and aPKC become planar polarized prior to mitosis in a manner independent of the AuroraA kinase and that PCP is required for the planar polarization of Baz, Par6, and aPKC during interphase. This indicates that a "mitosis rescue" mechanism establishes asymmetry at mitosis in PCP mutants. This study therefore identifies PCP as the initial symmetry-breaking signal for the planar polarization of PAR proteins in asymmetrically dividing SOPs. Copyright © 2015 Elsevier Ltd. All rights reserved.
uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERS

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Mariana Rodrigues Faleiro

2013-06-01

Full Text Available Prostatic lesions such as prostatic intraepithelial neoplasia (PIN and proliferative inflammatory atrophy (PIA are studied in human and canine species due to their malignance potential. The plasminogen activator (PA system has been suggested to play a central role in cell adhesion, angiogenesis, inflammation, and tumor invasion. The urokinase-type plasminogen activator receptor (uPAR is a component of the PA, with a range of expression in tumor and stromal cells. In this study, uPAR expression in both canine normal prostates and with proliferative disorders (benign prostatic hyperplasia-BPH, proliferative inflammatory atrophy-PIA, prostatic intraepithelial neoplasia-PIN, and carcinoma-PC was evaluated by immunohistochemistry in a tissue microarray (TMA slide to establish the role of this enzyme in extracellular matrix (ECM remodeling and in the processes of tissue invasion. A total of 298 cores and 355 diagnoses were obtained, with 36 (10.1% normal prostates, 46 (13.0% with BPH, 128 (36.1% with PIA, 74 (20.8% with PIN and 71 (20.0% with PC. There is variation in the expression of uPAR in canine prostate according to the lesion, with lower expression in normal tissue and with BPH, and higher expression in tissue with PIA, PIN and PC. The high expression of uPAR in inflammatory and neoplastic microenvironment indicates increased proteolytic activity in canine prostates with PIA, PIN, and PC.
In vitro and in vivo inhibition of proangiogenic retinal phenotype by an antisense oligonucleotide downregulating uPAR expression.

Science.gov (United States)

Lulli, Matteo; Cammalleri, Maurizio; Granucci, Irene; Witort, Ewa; Bono, Silvia; Di Gesualdo, Federico; Lupia, Antonella; Loffredo, Rosa; Casini, Giovanni; Dal Monte, Massimo; Capaccioli, Sergio

2017-08-26

Neoangiogenesis is the main pathogenic event involved in a variety of retinal diseases. It has been recently demonstrated that inhibiting the urokinase-type plasminogen activator receptor (uPAR) results in reduced angiogenesis in a mouse model of oxygen-induced retinopathy (OIR), establishing uPAR as a therapeutic target in proliferative retinopathies. Here, we evaluated in cultured human retinal endothelial cells (HRECs) and in OIR mice the potential of a specific antisense oligodeoxyribonucleotide (ASO) in blocking the synthesis of uPAR and in providing antiangiogenic effects. uPAR expression in HRECs was inhibited by lipofection with the phosphorotioated 5'-CGGCGGGTGACCCATGTG-3' ASO-uPAR, complementary to the initial translation site of uPAR mRNA. Inhibition of uPAR expression via ASO-uPAR was evaluated in HRECs by analyzing VEGF-induced tube formation and migration. In addition, the well-established and reproducible murine OIR model was used to induce retinal neovascularization in vivo. OIR mice were injected intraperitoneally with ASO-uPAR and retinopathy was evaluated considering the extent of the avascular area in the central retina and neovascular tuft formation. The ASO-uPAR specifically decreased uPAR mRNA and protein levels in HRECs and mitigated VEGF-induced tube formation and cell migration. Noteworthy, in OIR mice ASO-uPAR administration reduced both the avascular area and the formation of neovascular tufts. In conclusion, although the extrapolation of these experimental findings to the clinic is not straightforward, ASO-uPAR may be considered a potential therapeutic tool for treatment of proliferative retinal diseases. Copyright © 2017 Elsevier Inc. All rights reserved.
Protease activated receptors (PARS) mediation in gyroxin biological activity

International Nuclear Information System (INIS)

Silva, Jose Alberto Alves da

2009-01-01

Gyroxin is a serine protease enzyme from the South American rattlesnake (Crotalus durissus terrificus) venom; it is only partially characterized and has multiple activities. Gyroxin induces blood coagulation, blood pressure decrease and a neurotoxic behavior named barrel rotation. The mechanisms involved in this neurotoxic activity are not known. Whereas gyroxin is a member of enzymes with high potential to become a new drug with clinical applications such as thrombin, batroxobin, ancrod, tripsyn and kalicrein, it is important to find out how gyroxin works. The analysis on agarose gel electrophoresis and circular dichroism confirmed the molecules' integrity and purity. The gyroxin intravenous administration in mice proved its neurotoxicity (barrel rotation). In vivo studies employing intravital microscopy proved that gyroxin induces vasodilation with the participation of protease activated receptors (PARs), nitric oxide and Na+K+ATPase. The leukocytes' adherence and rolling counting indicated that gyroxin has no pro inflammatory activity. Gyroxin induced platelet aggregation, which was blocked by inhibitors of PAR1 and PAR4 receptors (SCH 79797 and tcY-NH 2 , respectively). Finally, it was proved that the gyroxin temporarily alter the permeability of the blood brain barrier (BBB). Our study has shown that both the protease-activated receptors and nitric oxide are mediators involved in the biological activities of gyroxin. (author)
Avis 6 sur la formation à et par la recherche

OpenAIRE

Centre de Coopération Internationale en Recherche Agronomique pour le Développement

2015-01-01

La formation à et par la recherche s’appuie sur la démarche scientifique, les savoirs, les connaissances à transmettre, tout autant que l’acquisition de compétences en gestion de projet, de capacités au travail en équipe, d’une ouverture d’esprit qui favorisera la créativité. Elle doit permettre de prendre conscience de la responsabilité endossée par la communauté scientifique vis-à-vis de la société et de l’environnement, mais aussi préparer l’avenir professionnel de celle ou de celui qu...
Désadification biologique des vins par les levures de fleur

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C. LLAGUNO

1971-03-01

Le processus de désacidification bactérienne du vin par la fermentation malolactique est bien connu. Le vin acquiert ainsi une plus grande souplesse au goût et une stabilité biologique indispensable à sa conservation en bouteilles. Cependant, les levures Schizosaccharomyces pombe peuvent aussi fermenter l'acide malique (RIBÉREAU-GAYON et PEYNAUD, 1962. TARANTOLA et GANDINI, 1967 ont décrit des essais semi-industriels de désacidification biologique d'un moût blanc piémontais ; provoquée aussi bien par l'ensemencement de bactéries malolactiques que de Schizosaccharomyces pombe.

"Parīzes šiks" mūsdienu restorānu interjera dizainā

OpenAIRE

Kalnarāja, Agnese

2015-01-01

Diplomdarbā “Parīzes šiks mūsdienu restorānu interjera dizainā” sastāv no piecām nodaļām. Pirmajā nodaļā tiek aprakstīta Parīzes arhitektūras un interjera dizaina vēsture, tā ietekme uz “Parīzes šika” veidošanos, kā arī pētīta restorānu vēsture. Otrajā nodaļā tiek pētīti elementi, kas raksturo “Parīzes šika” interjeru. Trešajā nodaļā tiek analizēti un aprakstīti psiholoģiskie faktori, kas ietekmē restorānu dizainu – apgaismojums, krāsu lietojums un atmosfēras nozīme interjerā. Empīriskajā...
Funding Research Through the Online Partnership to Accelerate Research (OnPAR

Directory of Open Access Journals (Sweden)

Martin A. Dueñas, MPA

2016-10-01

Full Text Available OnPAR—the Online Partnership to Accelerate Research—seeks to provide a second opportunity for funding of high-quality, unfunded applications originally submitted to the National Institutes of Health and other national and international funding agencies. OnPAR will match applicable, unfunded applications with the research priorities of nongovernment organizations such as private biomedical foundations, pharmaceutical companies, venture capital funds, and other private funds. Funding organization members will review and make final funding decisions through a simple, 2-step process whereby applicants can submit public abstracts directly to OnPAR. If a member requests additional information, then, by invitation only, an applicant can submit their original unfunded application and their peer review summary statement. Advancing research discovery and drug development to improve clinical outcomes for patients afflicted with or at risk for disease is the primary goal of OnPAR. OnPAR invites the scientific community to fully participate in this new funding paradigm by submitting their National Institutes of Health public abstracts so that funding members can review and potentially support these high-quality, unfunded applications.
Factor Xa stimulates fibroblast procollagen production, proliferation, and calcium signaling via PAR1 activation

International Nuclear Information System (INIS)

Blanc-Brude, Olivier P.; Archer, Fabienne; Leoni, Patricia; Derian, Claudia; Bolsover, Steven; Laurent, Geoffrey J.; Chambers, Rachel C.

2005-01-01

Fibroblast proliferation and procollagen production are central features of tissue repair and fibrosis. In addition to its role in blood clotting, the coagulation cascade proteinase thrombin can contribute to tissue repair by stimulating fibroblasts via proteolytic activation of proteinase-activated receptor-1 (PAR 1 ). During hemostasis, the coagulation cascade proteinase factor X is converted into factor Xa. We have previously shown that factor Xa upregulates fibroblast proliferation via production of autocrine PDGF. In this study, we further examined the effects of factor Xa on fibroblast function and aimed to identify its signaling receptor. We showed that factor Xa stimulates procollagen promoter activity and protein production by human and mouse fibroblasts. This effect was independent of PDGF and thrombin production, but dependent on factor Xa proteolytic activity. We also showed that PAR 1 -deficient mouse fibroblasts did not upregulate procollagen production, mobilize cytosolic calcium, or proliferate in response to factor Xa. Desensitization techniques and PAR 1 -specific agonists and inhibitors were used to demonstrate that PAR 1 mediates factor Xa signaling in human fibroblasts. This is the first report that factor Xa stimulates extracellular matrix production. In contrast with endothelial cells and vascular smooth muscle cells, fibroblasts appear to be the only cell type in which the effects of factor Xa are mediated mainly via PAR 1 and not PAR 2 . These findings are critical for our understanding of tissue repair and fibrotic mechanisms, and for the design of novel approaches to inhibit the profibrotic effects of the coagulation cascade without compromising blood hemostasis
Recherche documentaire par titrage automatique

OpenAIRE

Lopez , Cédric; Prince , Violaine; Roche , Mathieu

2011-01-01

Nous proposons dans cet article un système facilitant la recherche d'information dans un ensemble de documents textuels, basé sur le titrage (et sous-titrage) automatique. Ce dernier peut se révéler crucial, par exemple, dans le cadre de la problématique de l'accessibilité des pages web (norme W3C). Notre processus de titrage automatique consiste à extraire des syntagmes nominaux pertinents dans les textes, pouvant constituer des titres ou sous-titres candidats. Une approche originale combina...
Urokinase-type plasminogen activator receptor (uPAR) as a promising new imaging target

DEFF Research Database (Denmark)

Persson, Morten; Kjaer, Andreas

2013-01-01

modalities such as optical imaging, magnetic resonance imaging, single photon emission computer tomography (SPECT) and positron emission topography (PET). In this review, we will discuss recent advances in the development of uPAR-targeted imaging ligands according to imaging modality. In addition, we...... will discuss the potential future clinical application for uPAR imaging as a new imaging biomarker....
Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells.

Science.gov (United States)

Tripathi, Trivendra; Abdi, Mahshid; Alizadeh, Hassan

2014-05-29

Acanthamoeba plasminogen activator (aPA) is a serine protease elaborated by Acanthamoeba trophozoites that facilitates the invasion of trophozoites to the host and contributes to the pathogenesis of Acanthamoeba keratitis (AK). The aim of this study was to explore if aPA stimulates proinflammatory cytokine in human corneal epithelial (HCE) cells via the protease-activated receptors (PARs) pathway. Acanthamoeba castellanii trophozoites were grown in peptone-yeast extract glucose for 7 days, and the supernatants were collected and centrifuged. The aPA was purified using the fast protein liquid chromatography system, and aPA activity was determined by zymography assays. Human corneal epithelial cells were incubated with or without aPA (100 μg/mL), PAR1 agonists (thrombin, 10 μM; TRAP-6, 10 μM), and PAR2 agonists (SLIGRL-NH2, 100 μM; AC 55541, 10 μM) for 24 and 48 hours. Inhibition of PAR1 and PAR2 involved preincubating the HCE cells for 1 hour with the antagonist of PAR1 (SCH 79797, 60 μM) and PAR2 (FSLLRY-NH2, 100 μM) with or without aPA. Human corneal epithelial cells also were preincubated with PAR1 and PAR2 antagonists and then incubated with or without PAR1 agonists (thrombin and TRAP-6) and PAR2 agonists (SLIGRL-NH2 and AC 55541). Expression of PAR1 and PAR2 was examined by quantitative RT-PCR (qRT-PCR), flow cytometry, and immunocytochemistry. Interleukin-8 expression was quantified by qRT-PCR and ELISA. Human corneal epithelial cells constitutively expressed PAR1 and PAR2 mRNA. Acanthamoeba plasminogen activator and PAR2 agonists significantly upregulated PAR2 mRNA expression (1- and 2-fold, respectively) (P aPA, and PAR2 agonists induced PAR2 mRNA expression in HCE cells (P aPA, significantly upregulated PAR1 mRNA expression, which was significantly inhibited by PAR1 antagonist in HCE cells. Acanthamoeba plasminogen activator and PAR2 agonists stimulated IL-8 mRNA expression and protein production, which is significantly diminished by PAR2 antagonist
Parĳs is een meervoud. Adriaan van Dis en de heruitvinding van de Hollander in Parĳs

NARCIS (Netherlands)

Koffeman, M.N.; Koffeman, Maaike; Montoya, Alicia C.; Smeets, Marc

2017-01-01

Parĳs, tot halverwege de 20ste eeuw het onbetwiste centrum van de Europese cultuur, heeft van oudsher een grote aantrekkingskracht uitgeoefend op Nederlandse kunstenaars en schrĳvers. Velen van hen verbleven er kortere of langere tĳd, op zoek naar internationale erkenning. De vrĳere seksuele moraal
Childhood Pars Planitis; Clinical Features and Outcomes

Directory of Open Access Journals (Sweden)

Homayoon Nikkhah

2011-01-01

Full Text Available Purpose: To evaluate the demographic and clinical features of childhood pars planitis, and to determine the therapeutic and visual outcomes of the disease. Methods: Medical records of pediatric patients (less than 16 years of age at diagnosis with pars planitis and at least 6 months of follow-up who were referred to Labbafinejad Medical Center, Tehran, Iran over a 22 year period were reviewed. Results: Overall, 117 eyes of 61 patients including 51 (83.6% male subjects were included. Mean age at the time of diagnosis was 7.8΁3.2 (range, 3-16 years. Mean best corrected visual acuity (BCVA was 0.88΁0.76 logMAR at presentation which improved to 0.39΁0.51 logMAR at final visit (P<0.001. Endotheliitis was present in 23 (19.6% eyes and was significantly more prevalent in subjects younger than 9 years (P=0.025. Cataract formation (41.9% and cystoid macular edema (19.7% were the most prevalent complications. Univariate regression analysis showed that better baseline visual acuity (OR=0.38, 95%CI 0.21-0.70, P=0.002, age older than 5 years at disease onset (OR=0.36, 95%CI 0.14-0.9, P=0.029, absence of endotheliitis (OR=0.39, 95%CI 0.15-0.99, P=0.047 and female gender (OR=3.77, 95%CI 1.03-13.93, P=0.046 were significantly associated with final BCVA of 20/40 or better. Conclusion: Childhood pars planitis was much more common among male subjects. Endotheliitis may be a sign of inflammation spillover and is more prevalent in younger patients. Visual prognosis is favorable in most patients with appropriate treatment.
suPAR associates to glucose metabolic aberration during glucose stimulation in HIV-infected patients on HAART

DEFF Research Database (Denmark)

Andersen, Ove; Eugen-Olsen, Jesper; Kofoed, Kristian

2008-01-01

extend these findings by investigating the association of suPAR to glucose metabolic insufficiency during an oral glucose challenge (OGTT). METHODS: In 16 HIV-infected patients with lipodystrophy and 15 HIV-infected patients without lipodystrophy, glucose tolerance, insulin sensitivity (ISI......PAR correlated inversely with ISI(composite) and positively with 2h plasma glucose, fasting insulin secretion, fasting intact proinsulin and FFA level during the OGTT (all P...-RNA, duration of HIV infection), and dyslipidemia (plasma total cholesterol, triglyceride and free fatty acid level during the OGTT) were included, suPAR remained a significant marker of glucose tolerance and insulin sensitivity. Plasma suPAR exhibited a small CV (11%) during the 3h OGTT. CONCLUSIONS: su...
Non-Destructive Testing in Reactor Pressure-Vessel Fabrication; Essais non Destructifs dans la Fabrication des Caissons Etanches de Reacteurs; Nedestruktivnoe ispytanie pri izgotovlenii reaktornykh bakov vysokogo davleniya; Ensayo no Destructivo Durante la Fabricacion de Recipientes de Presion para Reactores

Energy Technology Data Exchange (ETDEWEB)

McGonnagle, W. J. [Fluids Dynamics Research, Iit Research Institute, Chicago, IL (United States)

1965-09-15

of the pressure vessel are discussed. (author) [French] Le memoire a pour objet d'exposer les grandes lignes d'un programme de controle de la qualite dans la fabrication d'un caisson etanche de reacteur qui satisfera a toutes les specifications du point de vue nucleaire et de la securite, et de mettre en evidence le role et l'importance des essais non destructifs dans ce programme. Les defauts constates dans les materiaux, les elements et leur assemblage montrent que les methodes actuelles de fabrication ne permettent pas en elles-memes d'assurer le maintien de la qualite des elements critiques. 11 se produit des pailles et des heterogeneites memes lorsque l'on utilise les meilleurs procedes de fabrication et que l'on applique des methodes et techniques dument controlees. C'est pourquoi, afin d'obtenir la qualite requise pour un caisson de reacteur, il faut executer un programme approprie et coherent d'essais non destructifs. Les principales methodes d'essais non destructifs appliquees par les fabricants de caissons de reacteurs sont les suivantes: inspection visuelle, radiographie par les rayons X ou gamma, ultrasons, particules magnetiques et penetration de liquides. Le programme d'essais non destructifs comporte le controle des materiau', du forgeage, du moulage, du gainage et des soudures. L'auteur etudie les problemes particuliers que posent les essais non destructifs des caissons etanches. Il decrit et discute les techniques speciales propres aux essais non destructifs des caissons et de leurs elements. Le memoire donne un apercu des reglements et specifications applicables, notamment du reglement de fabrication des bouilleurs et caissons etanches publie par la Societe americaine des ingenieurs mecaniciens. L'auteur etudie la mesure dans laquelle les essais non destructifs peuvent contribuer a repondre aux specifications imposees par les institutions de normalisation, ainsi que la mesure dans laquelle les normes admises pour ces essais sont appropriees et
Calculation of reactivity by digital processing; Calcul de la reactivite par traitement numerique

Energy Technology Data Exchange (ETDEWEB)

Hedde, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1968-12-01

With a view to exploring the new possibilities offered by digital techniques, a description is given of the optimum theoretical conditions of a computation of the realtime reactivity using counting samples (obtained from a nuclear reactor). The degree to which these optimum conditions can be attained depends on the complexity of the processing which can be accepted. A compromise thus has to be made between the accuracy required and the simplicity of the equipment carrying out the processing. An example is given, using a relatively simple structure, which gives an idea of the accuracy of the results obtained over a wide range of reactor power. (author) [French] Dans le but d'explorer les possibilites nouvelles des techniques numeriques, on decrit les conditions theoriques optimales d'un calcul de la reactivite en temps reel a partir d'echantillons de comptage (en provenance d'un reacteur nucleaire). Ces conditions optimales peuvent etre approchees d'autant mieux que l'on accepte un traitement plus complexe. Un compromis est donc a faire entre la precision desiree et la simplicite du materiel assurant le traitement. Un exemple adoptant une structure de complexite reduite permet de juger de la precision des resultats obtenus sur une importante plage d'evolution de la puissance. (auteur)
Calculation of reactivity by digital processing; Calcul de la reactivite par traitement numerique

Energy Technology Data Exchange (ETDEWEB)

Hedde, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1968-12-01

With a view to exploring the new possibilities offered by digital techniques, a description is given of the optimum theoretical conditions of a computation of the realtime reactivity using counting samples (obtained from a nuclear reactor). The degree to which these optimum conditions can be attained depends on the complexity of the processing which can be accepted. A compromise thus has to be made between the accuracy required and the simplicity of the equipment carrying out the processing. An example is given, using a relatively simple structure, which gives an idea of the accuracy of the results obtained over a wide range of reactor power. (author) [French] Dans le but d'explorer les possibilites nouvelles des techniques numeriques, on decrit les conditions theoriques optimales d'un calcul de la reactivite en temps reel a partir d'echantillons de comptage (en provenance d'un reacteur nucleaire). Ces conditions optimales peuvent etre approchees d'autant mieux que l'on accepte un traitement plus complexe. Un compromis est donc a faire entre la precision desiree et la simplicite du materiel assurant le traitement. Un exemple adoptant une structure de complexite reduite permet de juger de la precision des resultats obtenus sur une importante plage d'evolution de la puissance. (auteur)
Some economic aspects of natural uranium graphite gas reactor types. Present status and trends of costs in France; Quelques aspects economiques de la filiere uranium naturel - Graphite - gaz. Etat actuel et tendance des couts en France

Energy Technology Data Exchange (ETDEWEB)

Gaussens, J; Tanguy, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Leo, B [Electricite de France (EDF), 75 - Paris (France)

1964-07-01

reduction in investment costs can be obtained without relying on fuel enrichment, and that this development is accompanied moreover by improvements in the operational safety of the reactor. The economic aspects of the main technical problems entailed by these developments are discussed: loading and unloading machines, blowers etc... (authors) [French] Dans une premiere partie, on situe l'interet economique de l'utilisation de l'uranium naturel comme combustible. Cet interet reside a la fois dans le nombre limite et la simplicite relative des operations de mise en forme des elements combustibles, dans le faible cout du produit fini par kwh et dans les immobilisations modestes en capital qu'implique ce cycle par rapport ou cycle de l'uranium enrichi. Tous ces elements permettent de reduire le caractere aleatoire des evaluations des couts, particulierement marque dans le cas de l'uranium enrichi, en raison de la complexite de son cycle et des incertitudes concernant le prix du plutonium. Enfin, la diversite des sources d'approvisionnement en concentre d'uranium naturel opposee au quasi monopole actuel de la separation isotopique, et le faible cout du stockage de ce concentre, offrent des garanties en matiere de securite d'approvisionnement et d'independance economique et politique appreciables par rapport a l'uranium enrichi. En ce qui concerne l'ensemble des capitaux immobilises, on montre que si le cout des centrales au graphite-gaz est plus eleve que celui des centrales eau legere pour certaines gammes de puissance, ce resultat est fortement nuance des que l'on fait intervenir dans un souci d'independance nationale le cout de l'equipement de production des combustibles de l'une et l'autre filiere. Enfin, le cout marginal de la puissance du reacteur au graphite est faible, ses limitations technologiques ont considerablement recule (grace en particulier a l'utilisation du beton precontraint). On sait que la tendance actuelle est a l'accroissement de la puissance unitaire des
Eficacia de los antivirales en la parálisis de Bell

OpenAIRE

Vázquez, María Cristina; Sánchez, Nury; Calvo, Judith; Perna, Abayubá

2008-01-01

Introducción: la parálisis de Bell es una afección frecuente que presenta en 15% de los casos una recuperación incompleta. En los últimos años se ha acumulado evidencia del posible rol del virus herpes simple tipo 1 en su etiología. Objetivos: comparar la eficacia de valaciclovir y prednisona versus prednisona placebo en la parálisis de Bell. Material y método: se realizó un ensayo prospectivo, randomizado y placebo controlado. De los 41 pacientes incluidos, 21 fueron tratados con valaciclovi...
CRP and suPAR are differently related to anthropometry and subclinical organ damage

DEFF Research Database (Denmark)

Lyngbæk, Stig; Sehestedt, Thomas; Marott, Jacob L

2013-01-01

BACKGROUND: Low-grade inflammation is a marker for cardiovascular disease (CVD). The inflammatory biomarkers C-reactive protein (CRP) and soluble urokinase plasminogen activator receptor (suPAR) independently predict CVD. We tested the hypothesis that these biomarkers reflect different aspects...... of the inflammation associated with CVD. METHODS: We studied 2273 subjects without CVD. Log-transformed CRP and suPAR were included in general linear and logistic regression models to compare associations with measures of anthropometry and subclinical organ damage (SOD). Owing to interactions on body mass index (BMI......) (P3: 1.31 (1.16-1.47), whereas log-CRP was not (1.00 (0.89-1.11))). CONCLUSIONS: CRP is positively associated with anthropometric measures, whereas suPAR is linked to endothelial dysfunction and atherosclerosis....
Sucralfate modulates uPAR and EGFR expression in an experimental rat model of cervicitis.

Science.gov (United States)

Mannari, C; Santi, S; Migliori, M; Filippi, C; Origlia, N; Sansò, M; Boldrini, E; Giovannini, L

2008-01-01

Sucralfate is a drug used in the treatment of gastric and duodenal ulcer; it is cytoprotective and able to increase the bioavailability of several growth factors, modulating the wound healing process. In this study we tested the possible therapeutic effect of Sucralfate in the treatment of ulcerative lesions occurring in uterine cervix; to investigate such effect we used an experimental rat model of cervicitis in which the uPAR and EGFR expression were evaluated. Cervicitis was induced in wild and ovariectomized Wistar female rats by an acetic acid-soaked tampon. The animals were divided into two main groups (4 and 7 days) and Sucralfate was administered topically until the day they were sacrificed. In order to distinguish physiological and drug-induced healing, quantitative and qualitative uPAR and EGFR expression were evaluated by using Western blot and Immunohistochemistry techniques. Western blot analysis demonstrated an increased expression of both receptors after 4 days from wounding in wild and ovariectomized animals. In particular in ovariectomized animals the expression of uPAR and EGFR increased after 4 days while it reduced following the administration of Sucralfate. In wild rats the same was observed for uPAR expression, while EGFR was different; in fact, its expression increased significantly at day 4 in the animals treated with the drug and only at day 7 in those untreated. Immunohistochemistry highlighted a noteworthy epithelial colocalization of EGFR and uPAR after 4 days in the animals treated with Sucralfate. We conclude that Sucralfate can promote the healing of ulcerative cervicitis and moreover, it reduces the normal healing time because of its modulatory property on uPAR and EGFR expression.
The role of gyrA and parC mutations in fluoroquinolones-resistant Pseudomonas aeruginosa isolates from Iran

Directory of Open Access Journals (Sweden)

Roghayeh Nouri

Full Text Available Abstract The aim of this study was to examine mutations in the quinolone-resistance-determining region (QRDR of gyrA and parC genes in Pseudomonas aeruginosa isolates. A total of 100 clinical P. aeruginosa isolates were collected from different university-affiliated hospitals in Tabriz, Iran. Minimum inhibitory concentrations (MICs of ciprofloxacin and levofloxacin were evaluated by agar dilution assay. DNA sequences of the QRDR of gyrA and parC were determined by the dideoxy chain termination method. Of the total 100 isolates, 64 were resistant to ciprofloxacin. No amino acid alterations were detected in gyrA or parC genes of the ciprofloxacin susceptible or ciprofloxacin intermediate isolates. Thr-83 → Ile substitution in gyrA was found in all 64 ciprofloxacin resistant isolates. Forty-four (68.75% of them had additional substitution in parC. A correlation was found between the number of the amino acid alterations in the QRDR of gyrA and parC and the level of ciprofloxacin and levofloxacin resistance of the P. aeruginosa isolates. Ala-88 → Pro alteration in parC was generally found in high level ciprofloxacin resistant isolates, which were suggested to be responsible for fluoroquinolone resistance. These findings showed that in P. aeruginosa, gyrA was the primary target for fluoroquinolone and additional mutation in parC led to highly resistant isolates.
Some physics aspects of cermet and ceramic fast systems; Quelques aspects de la physique des reacteurs a neutrons rapides utilisant des cermets et des ceramiques comme combustibles; Nekotorye fizicheskie aspekty kermetnykh i keramicheskikh sistem na bystrykh nejtronakh; Algunos aspectos fisicos de los sistemas rapidos a base de combustibles cermet y ceramicos

Energy Technology Data Exchange (ETDEWEB)

Codd, J; James, M F; Mann, J E [United Kingdom Atomic Energy Authority, Reactor Group (United Kingdom)

1962-03-15

The characteristics of a system using an iron-based oxide cermet as fuel material are discussed. A transport theory investigation to develop methods of predicting the effect of core heterogeneity on reactivity and flux distribution is described. Some preliminary calculations are also given of resonance self-shielding and Doppler temperature effects in a cermet system. (author) [French] Les auteurs etudient les caracteristique s d'un reacteur utilisant comme combustible un cermet d'oxydes a armature de fer. Ils exposent une application de la theorie du transport a la mise au point des methodes permettant de prevoir l'effet de l'heterogeneite du coeur sur la reactivite et sur la distribution du flux. Ils donnent egalement quelques calculs preliminaires d'effets d'autoprotection due a la resonance et d'effet Doppler du a la chaleur dans un reacteur utilisant un cermet. (author) [Spanish] La memoria discute las caracteristicas de un sistema que emplea como combustible un oxido tipo cermet a base de hierro. Describe una investigacion de la teoria de transporte con miras a desarrollar metodos para evaluar el efecto de la heterogeneidad del cuerpo sobre la reactividad y la distribucion de flujo. Tambien da algunos calculos preliminares de los efectos del autoblindaje por resonancia y de la temperatura de Doppler en un sistema de tipo cermet. (author) [Russian] Obsuzhdayutsya kharakteristiki sistemy, ispol'zuyushchej v kachestve toplivnogo materiala oksidnye kermety, razrabotannye na osnove zheleza. Opisyvaetsya issledovanie teorii perenosa, chtoby razvit' metody predskazaniya vliyaniya geterogennosti aktivnoj zony na reaktivnost' i raspredelenie potoka. Dayutsya takzhe nekotorye predvaritel'nye raschety ehffektov rezonansnoj samozashchity i temperaturnogo ehffekta Dopplera v kermetnoj sisteme. (author)
Contribution de la tomographie par coherence optique au diagnostic ...

African Journals Online (AJOL)

Contribution de la tomographie par coherence optique au diagnostic de la neuropathie optique toxique. C.O.A. Abouki, S Alamou, C.R.A. Assavedo, L Odoulami-Yehouessi, I Sounouvou, S Hounnou-Tchabi ...
La lecture de Merleau-Ponty par Renaud Barbaras

Czech Academy of Sciences Publication Activity Database

Pechar, Jiří

2015-01-01

Roč. 11, č. 2 (2015), s. 1-6 ISSN 1336-6556 Institutional support: RVO:67985955 Keywords : Merleau-Ponty * Husserl * phenomenology * linguistics of Ferdinand de Saussure Subject RIV: AA - Philosophy ; Religion http://www.ostium.sk/sk/la-lecture-de-merleau-ponty-par-renaud-barbaras/

Monoradiculopathy and secondary segmental instability caused by postoperative pars interarticularis fracture: a case report.

Science.gov (United States)

Kaner, Tuncay; Tutkan, Ibrahim

2009-04-01

Instability can develop after lumbar spinal surgery. What is also known as secondary segmental instability is one of the important causes of failed back syndrome. In this paper, we described a 45-year-old female patient who was diagnosed with secondary segmental instability caused by left L3 pars interarticularis fracture after a high lumbar disc surgery and was subsequently treated with re-operation. We evaluated the clinical course, diagnosis, and treatment methods for secondary segmental instability caused by postoperative pars interarticularis fracture. Furthermore, we emphasized the importance of preserving the pars interarticularis during upper lumbar disc surgeries in order to avoid a potential stress fracture.
Influence of P-Reactor operation on the aquatic ecology of Par Pond: a literature review

International Nuclear Information System (INIS)

Wilde, E.W.; Tilly, L.J.

1985-02-01

Par Pond is a 1012 hectare reservoir that was constructed in 1958 to provide cooling water for Savannah River nuclear reactors. The purpose of this report is to summarize all known studies on the Par Pond system and point out demonstrable or probable effects that can be correlated with reactor operations. Reactor operation effects the Par Pond ecosystem through: (1) pumping, (2) thermal alteration, and (3) the addition of Savannah River makeup water. The influence of each of these factors is discussed. 108 references, 24 figures, 34 tables. (MF)
Par Pond refill water quality sampling

International Nuclear Information System (INIS)

Koch, J.W. II; Martin, F.D.; Westbury, H.M.

1996-08-01

This study was designed to document anoxia and its cause in the event that the anoxia caused a fish kill. However, no fish kill was observed during this study, and dissolved oxygen and nutrient concentrations generally remained within the range expected for southeastern reservoirs. Par Pond water quality monitoring will continue during the second summer after refill as the aquatic macrophytes become reestablished and nutrients in the sediments are released to the water column
Self-Absorption Studies with a 4 {pi} {beta}-Proportional Flow Counter; Etudes sur l'autoabsorption avec un compteur {beta} 4 {pi} proportionnel a courant; Izuchenie samopogloshcheniya pri pomoshchi {beta} proportsional'no-potochnogo 4 {pi} schetchika; Estudios sobre autoabsorcion con un contador de flujo proporcional {beta}4 {pi}

Energy Technology Data Exchange (ETDEWEB)

Yaffe, L; Fishman, J B [Radiochemistry Laboratory, Dept. of Chemistry, McGill University, Montreal, Quebec (Canada)

1960-06-15

Self-absorption studies of {beta} emitters have been made by means of the techniques outlined by Pate and Yaffe [Can. J. Chem. 34, 265 (1956)]. Volatile compounds of H''3, C''1''4, Co''6''0, Hg''2''0''3, As''7''7, and P{sup 32} (E{sub max} ranging from 0.018 to 1.7 MeV) were distilled on to thin VYNS mounts and the self-absorption characteristics determined. An empirically determined series of curves relating E{sub max}, source thickness, and self-absorption is given. The self-absorption data have been subjected to a theoretical analysis for counters of small angle and 4{pi} geometry. The experimentally determined self-absorption curves for 4 {pi} geometry lie in between the theoretical small angles and 4 {pi} geometry curves. (author) [French] Des etudes sur l'autoabsorption des emetteurs {beta} ont ete faites selon les techniques indiquees par Pate and Yaffe [Can. J. Chem. 34, 265 (1956)]. Des composes volatils de H{sup 3}, S{sup 14}, Co{sup 60}, Hg{sup 203}, As{sup 77} et P{sup 32} (E{sub max} allant de 0,018 a 1,7 MeV), ont ete recueillis par distillation sur des supports minces en resine vynilique (VYNS) et les caracteristiques de l'autoabsorption ont ete determinees. Le memoire contient une serie de courbes determinees empiriquement, qui donnent les relations entre E{sub max} l'epaisseur de la source et l'autoabsorption . Les donnees sur l'autoabsorption ont fait l'objet d'une analyse theorique pour les compteurs a geometrie de petit angle solide et 4 {pi}. Les courbes d'auto- absorption determinees experimentalemen t pour la geometrie 4 {pi} sont comprises entre les courbes theoriques correspondant a la geometrie de petit angle solide et a la geometrie 4 {pi}. (author) [Spanish] Les autores han estudiado la autoabsorcion de los emisores {beta} utilizando las tecnicas descritas por Pate y Yaffe [Can. J. Chem. 34, 265 (1956)]. Han destilado compuestos volatiles de H{sup 3}, S{sup 14}, So{sup 60}, Hg{sup 203}, As{sup 77} y P{sup 32} (E{sub max} comprendida
Contribution to the chromatography of atmospheric gases (1963); Contribution a la chromatographie des gaz de l'air (1963)

Energy Technology Data Exchange (ETDEWEB)

Ghalamsiah, A [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1963-06-15

In the first part, the author studies the gas-phase chromatographic separation of the atmospheric rare gases, of hydrogen, and of some gaseous compounds of carbon (CO, CO{sub 2}, CH{sub 4}) using inactive gases to obtain the most favourable operational conditions far this separation. In the second part, the optimum conditions for detecting non-active gases using an ionisation chamber and a {sup 239}Pu radioactive source emitting 5.15 MeV {alpha} particles are determined. (author) [French] Dans une premiere partie, l'auteur etudie la separation par chromatographie en phase gazeuse des gaz rares de l'air, de l'hydrogene, et de quelques composes gazeux du carbone (CO, CO{sub 2}, CH{sub 4}) en utilisant des gaz inactifs an vue d'obtenir les conditions experimenales les plus favorables en vue de cette separation. Dans une deuxieme partie, les conditions optimales de detection de gaz non actifs a l'aide d'une chambre d'ionisation, en utilisant comme source radioactive du {sup 239}Pu qui emet des particules {alpha} de 5,15 MeV, sont determinees. (auteur)
ParShield: A computer program for calculating attenuation parameters of the gamma rays and the fast neutrons

International Nuclear Information System (INIS)

Elmahroug, Y.; Tellili, B.; Souga, C.; Manai, K.

2015-01-01

Highlights: • Description of the theoretical method used by the ParShield program. • Description of the ParShield program. • Test and validation the ParShield program. - Abstract: This study aims to present a new computer program called ParShield which determines the neutron and gamma-ray shielding parameters. This program can calculate the total mass attenuation coefficients (μ t ), the effective atomic numbers (Z eff ) and the effective electron densities (N eff ) for gamma rays and it can also calculate the effective removal cross-sections (Σ R ) for fast neutrons for mixtures and compounds. The results obtained for the gamma rays by using ParShield were compared with the results calculated by the WinXcom program and the measured results. The obtained values of (Σ R ) were tested by comparing them with the measured results,the manually calculated results and with the results obtained by using MERCSFN program and an excellent agreement was found between them. The ParShield program can be used as a fast and effective tool to choose and compare the shielding materials, especially for the determination of (Z eff ) and (N eff ), there is no other programs in the literature which can calculate
SuPAR predicts postoperative complications and mortality in patients with asymptomatic aortic stenosis

DEFF Research Database (Denmark)

Hodges, Gethin W; Bang, Casper N; Eugen-Olsen, Jesper

2018-01-01

complications with a HR of 2.7 (95% CI 1.5 to 5.1, P=0.002), per doubling in suPAR. After adjusting for the European System for Cardiac Operative Risk Evaluation or Society of Thoracic Surgeons risk score, suPAR remained associated with postoperative mortality with a HR 3.2 (95% CI 1.2 to 8.6, P=0.025) and 2...
Evolution of nuclear chemical industry in France; Evolution de l'industrie chimique nucleaire en France

Energy Technology Data Exchange (ETDEWEB)

Fould, M H [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

1959-07-01

'impulsion du CEA, mais aussi de maitres d'oeuvres tels qu'Electricite de France et la Marine Marchande, l'effort nucleaire fran is atteint pour les annees 1957-1961, environ 600 milliards de francs: plus de la moitie de cette somme sera depensee par l'industrie chimique en recherches, installations pilotes, constructions d'usines et livraisons. Faire bien, vite et rentable sont les buts recherches. Ces objectifs sont atteints grace a une collaboration intime des grands services de l'etat et de l'industrie privee. Ce gros effort s'exerce principalement dans les voies suivantes: - Un traitement chimique pousse de tonnages croissants des minerais de l'Union fran ise, visant a produire un uranium pur, abondant et bon marche. - Une preparation soigneuse de combustibles nucleaires economiques et parfaitement adaptes aux divers types de reacteurs en fonctionnement ou en construction. - Un retraitement des combustibles irradies pour en extraire le plutonium de facon complete ainsi que l'uranium et certains produits de fission. - Une fabrication industrielle des materiaux nucleairement purs ou resistants a la corrosion exiges par la technologie des reacteurs producteurs d'energie et de recherches. - La fourniture aux multiples utilisateurs etrangers et fran is d'isotopes et de traceurs radioactifs reclames par la medecine, l'industrie et l'agriculture en nombre toujours croissant. - Un traitement chimique meticuleux des effluents gazeux ou liquides dans des stations au controle rigoureux afin de rendre les reacteurs et leurs annexes parfaitement surs d'emploi. Cet expose aura montre l'ampleur de l'effort deploye par une industrie chimique nucleaire jeune, dynamique et en plein essor. Ayant assure ses techniques, realise de nombreuses installations, elle est largement en etat de faire face au programme atomique fran is. En outre, elle est capable et desireuse d'etre associee aux developpements de l'industrie atomique etrangere notamment dans te cadre de l'Euratom et d
Results of Preliminary Tests of PAR Bunch Cleaning

CERN Document Server

Yao, Chihyuan; Grelick, Arthur; Lumpkin, Alex H; Sereno, Nicholas S

2005-01-01

A particle accumulator ring (PAR) is used at the Advanced Photon Source (APS) to collect multiple linac bunches and compress them into a 0.3-ns (rms) single bunch for booster injection. A 9.77-MHz fundamental rf system and a 117.3-MHz harmonic rf system are employed for initial beam capture and bunch length compression. Satellite bunches with very low charge form due to rf phase drifts or beam loading change. These satellites, when injected into the booster and then into the storage ring (SR), cause bunch impurity at three buckets from the target bucket. Storage ring and booster bunch cleaning was tried but proved to be difficult due to the top-up mode of operation in the storage ring and tune drift in the booster synchrotron. Recently we implemented a PAR bunch-cleaning system with tune-modulated harmonic rf knockout. Preliminary tests gave a measured SR bunch purity of better than 10
Analysis of clinical features and visual outcomes of pars planitis.

Science.gov (United States)

Berker, Nilufer; Sen, Emine; Elgin, Ufuk; Atilgan, Cemile Ucgul; Dursun, Erdem; Yilmazbas, Pelin

2018-04-01

To evaluate the demographic characteristics, clinical features, treatment and outcomes of patients with pars planitis in a tertiary referral center in Turkey. Medical records of patients with pars planitis were retrospectively reviewed. The data including demographic and ocular features and treatment outcomes were recorded. The distribution of clinical findings and complications were evaluated according to age and gender groups. The changes in final BCVA compared to the initial BCVA were noted. Statistical analysis was performed using SPSS software (Version 18.0, SPSS Inc., Chicago, USA). Twenty-seven patients (54 eyes) were included in this study. 16 patients were male (59.3%), and 11 were female (40.7%). Mean age at diagnosis was 12.84 ± 8.26 (range 4-36) years. Mean follow-up period was 61.3 ± 52.15 (range 9-172) months. Mean BCVA was 0.58 ± 0.36 (range 0.03-1.00) (0.40 ± 0.45 logMAR) at presentation, and 0.81 ± 0.28 (range 0.10-1.00) (0.14 ± 0.27 logMAR) at final visit (P = 0.001). Vitreous inflammation (100%), vitreous haze (92.6%), snowballs (74.1%), snowbanks (66.7%), anterior chamber cells (66.7%) and peripheral retinal vascular sheathing (48.1%) were the most common presentations. Ocular complications included vitreous condensation (51.9%), cystoid macular edema (22.2%), cataract (18.5%), inferior peripheral retinal detachment (11.1%), glaucoma (5.6%) and vitreous hemorrhage (3.7%). Treatments included topical, periocular, intravitreal and systemic corticosteroids, immunosuppressives, peripheral laser photocoagulation and pars plana vitrectomy when needed. Pars planitis is an idiopathic chronic intermediate uveitis mostly affecting children and adolescents. In spite of its chronic nature with high potential of causing ocular complications, adequate treatment and close follow-up lead to favorable visual outcomes.
Could soluble urokinase plasminogen receptor (suPAR) be used as a diagnostic biomarker for ventilator-associated pneumonia?

Science.gov (United States)

Sunnetcioglu, Aysel; Sunnetcioglu, Mahmut; Adıyaman, Fırat; Binici, Irfan; Soyoral, Lokman

2017-11-01

Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker that is increasingly used for evaluation of systemic inflammation. This study was performed to investigate whether suPAR may possess a diagnostic value in patients with ventilator-associated pneumonia (VAP). This clinical study was performed in the anesthesia intensive care units (ICUs) of our university. In addition to descriptive data, WBC, serum levels of C-reactive protein (CRP) and suPAR prior to and after development of VAP were noted and compared in 31 patients (22 men, 9 women) diagnosed with VAP (Study Group) and 19 patients without VAP (Control Group) in ICU (14 men, 5 women). The suPAR (P = 0.023), CRP (P = 0.037), WBCs (P = 0.024) in patients with VAP were significantly higher than patients without VAP. There was no remarkable difference in terms of WBCs (P = 0.052) and suPAR levels (P = 0.616) between groups on the first day of connection to mechanical ventilator. The suPAR and CRP levels in patients with VAP were significantly higher than prior to development of VAP (P = 0.001 for both). Area under curve value after diagnosis of pneumonia was found 0.248 (P = 0.002). To conclude, our results suggest that suPAR can be a useful diagnostic biomarker in patients with VAP. However, clinical trials on larger series are warranted to explore the clinical significance more accurately. © 2016 John Wiley & Sons Ltd.
Spectral variations of UV-A and PAR solar radiation in estuarine waters of Goa

Digital Repository Service at National Institute of Oceanography (India)

Talaulikar, M.; Suresh, T.; Silveira, N.; Desa, E.; Matondkar, S; Lotlikar, A

radiation (400 to 700 nm), PAR and ultraviolet radiation in the range 350-400 nm (UV-A) are presented here. The mean PAR values at the surface were 327 W/m sup(2) and reduced to 84 W/m sup(2) at first optical depth, Z sub(90) (m) in water. The first optical...
Repérer des sites similaires à une recherche par Google

OpenAIRE

Ginouvès, Véronique

2006-01-01

Repérer des sites similaires à une recherche par Google Afficher graphiquement les liens d’un site avec d’autres sites similaires TouchGraph GoogleBrowser crée des agrégations de sites à partir de l’interrogation de Google. Vous visualisez ainsi des nébuleuses de sites à l’intérieur desquelles vous pouvez naviguer facilement, en sautant d'un groupe à l'autre afin de voir les nuages autour de sujets ou de communautés de sujets. Cet outil a été développé par Alex Shapiro, à partir de la version...
Le dysfonctionnement socio-spatial des grands ensembles en Algérie: technique de l’analyse wayfinding par méthode “movement traces” et l’analyse morphologique (syntaxe spatiale par logiciel “depthmap”

Directory of Open Access Journals (Sweden)

Amara Hima

2018-03-01

Full Text Available Résumé La technique de l’analyse syntaxique de la visibilité (Visibility Graph Analysis – VGA et de l’accessibilité (All Line Analysis – ALA par logiciel “DepthMap©(UCL, Londres” et l’analyse du dysfonctionnement wayfinding par méthode “movement traces”, sont utilisées dans ce papier afin de développer un modèle d’analyse et d’investigation de l’impact des changements spatiaux sur le dysfonctionnement socio-spatial du wayfinding, ainsi sur la reproduction urbaine, notamment les transformations des façades et l’appropriation des espaces extérieurs dans les grands ensembles en Algérie. Nous donnons ici le cas d’étude de la cité 1000 logt-Biskra et la cité 500 logt-M’sila. Afin de vérifier cette hypothèse, un modèle d’analyse hybride a été développé par croisement des résultats d’analyses des deux techniques. Par conséquent, le schéma de l’interférence montre que la majorité des piétons préfèrent parcourir les axes courts et droits — caractérisés par une forte propriété syntaxique de visibilité et d’accessibilité (l’intégration, la connectivité et l’intelligibilité — en directions des équipements adjacents et aux milieux des deux cités. Ces itinéraires ont un impact sur les transformations des façades et l’appropriation des espaces extérieurs. Le modèle développé promet de futures recherches sur le plan de la quantification, la modélisation et la simulation du processus de la reproduction urbaine, notamment par les automates cellulaires.
Infection par le VIH chez les patientes atteintes de cancer du sein en ...

African Journals Online (AJOL)

L'objectif était de déterminer la prévalence de l'infection à VIH chez les patientes atteintes de cancer du sein et de comparer les caractéristiques anatomocliques et thérapeutiques de ces cancers du sein par rapports aux patientes non infectées par le VIH. Il s'agissait d'une étude rétrospective et analytique comparant les ...
A cluster of aspartic residues in the extracellular loop II of PAR 4 is important for thrombin interaction and activation of platelets.

Science.gov (United States)

Sánchez Centellas, Daniel; Gudlur, Sushanth; Vicente-Carrillo, Alejandro; Ramström, Sofia; Lindahl, Tomas L

2017-06-01

Thrombin activates platelets via proteolytic cleavage of protease-activated receptors (PARs) 1 and 4. The two PARs have distinct but complementary roles. The mechanisms responsible for PAR1 activation by thrombin have been extensively studied. However, much less is known regarding thrombin activation of PAR4, especially the potential involvement of regions of PAR4 other than the N-terminal, which is bound to the catalytic site of thrombin. We have studied PAR4 in S. cerevisiae strain MMY12, an expression system in which the GPCR receptors are connected to a Lac Z reporter gene resulting in increased β-galactosidase activity. This approach was used to assess PAR4 mutants to evaluate the contribution of different aspartic residues in facilitating PAR4 activation. Furthermore, peptides mimicking parts of the PAR4 N-terminal and the second extracellular loop (ECLII) were tested for their ability to inhibit platelet activation by thrombin. Binding of these peptides to γ-thrombin was studied by monitoring the decrease in tryptophan fluorescence intensity of thrombin. We conclude that not only the N-terminal but also the electronegative aspartic residues D224, D230 and D235 (located in ECLII) are be important for PAR4 binding to thrombin. We further suggest that they play a role for the tethered ligand binding to the receptor, as mutations also affected activation in response to a PAR4-activating peptide mimicking the new N-terminal formed after cleavage. This agrees with previous results on PAR1 and thrombin binding. We suggest that the ECLII of PAR4 could be a potential target for antithrombotic drug development. Copyright © 2017 Elsevier Ltd. All rights reserved.
Preliminary Analysis For Wolsong Par Effects Using ISACC Calculations

International Nuclear Information System (INIS)

Song, Yong Mann; Kim, Dong Ha

2012-01-01

In the paper, hydrogen control effects using PARs only are analyzed for severe SBO station blackout (SBO) sequences beyond the design basis accidents in WS-1 which are of CANDU6 type reactor. As a computational tool, the latest version of ISAAC4.3 (Integrated Severe Accident Analysis Code for CANDU), which is a fully integrated and lumped severe accident computer code, is used to simulate hydrogen generation and transport inside the reactor building (R/B) before its failure. For the performance of hydrogen removal, the depletion rate equation of K-PAR developed in Korea is applied. In a CANDU reactor, three areas are identified as sources of hydrogen under severe accidents: fuel-coolant interactions in intact channels, suspended fuel or debris interactions in-calandria tank and debris interactions in-calandria vault. The first two origins provide source for the late ('late' terminology is used because it takes more than one day before calandria tank failure) potential hydrogen combustion before calandria tank failure and all the three origins would provide source for the very late potential hydrogen combustion occurring at or after calaria tank failure. If the hydrogen mitigation system fails, the AICC (adiabatic isochoric complete combustion) burning of highly flammable hydrogen may cause Wolsong R/B failure. So hydrogen induced failure possibility is evaluated, using preliminary ISAAC calculations, under several SBO conditions with and without PAR for both late and very late accident periods
fortification des farines tropicales par l'introduction de proteines ...

African Journals Online (AJOL)

2Université d'Abomey Calavy, Faculté des Sciences et Techniques, Bénin ... valeur recommandée par le Codex Alimentarius pour ce type de complément alimentaire destiné aux enfants. ..... neurotransmission, coagulation sanguine et.
Ultrasonic Inspection following Heat Treatment of Uranium Alloys; Controle des Traitements Thermiques d'Alliage d'Uranium par Ultrasons; Kontrol' termicheskoj obrabotki uranovykh splavov s pomoshch'yu ul'trazvuka; Control Ultrasonico de los Tratamientos Termicos de Aleaciones de Uranio

Energy Technology Data Exchange (ETDEWEB)

Destribats, Marie-Therese; Cherpentier, C.; Papezik, F.; Pigeon, M. [Centre d' Etudes Nucleaires Desaclay (France)

1965-10-15

To improve the behaviour of low uranium alloys in reactors it is often necessary to reduce grain size by heat treatment. It has proved essential to provide for inspection of the whole element and the entire output in order to discover the exact quality of the fuel used. This inspection cannot be made by micrography because of the time required and the fact that the data obtained are incomplete. The inspection system adopted is based on the principle of absorption of ultrasonic waves by materials. This absorption depends on the structure of the medium. If {lambda} is small in relation to grain size G, absorption is low; whereas if G is of the order of {lambda}/2, absorption is very high. The tests were made first in air, using the multiple-echo system, then by measuring the height of the first echo, and finally by transmission in water, the height of the transmitted echo being compared with that of the initial signal. In industrial use, the amplitude of the echo transmitted by the material is compared with the echo obtained from a standard of the same characteristics and shape. Inspection takes place in a special machine in which the materials are rotated by rollers and adjustable transducers move over the element. The helicoidal scanning is carried out with a pitch of less than 5 mm. The ultrasonic generator includes a control system ensuring a constant reference echo. The paper quotes a series of records showing the results obtained with various alloys and in particular the faults observed in elements treated by induction upon linear displacement. The arrangement can detect faulty treatment zones of less than 1 cm{sup 2}. The system is at present used to inspect all low alloy uranium fuels of the G2, EL3, EDF1, EDF2 and INCA reactors, i.e. rods and tubes with diameters between 20 and 95 mm. (author) [French] Afin d'obtenir une meilleure tenue des alliages d'uranium faiblement allies dans les reacteurs, un affinage du grain par traitements thermiques est souvent
Parasitisme des champs semenciers de cacaoyers par les ...

African Journals Online (AJOL)

SARAH

30 janv. 2015 ... J. Appl. Biosci. Parasitisme des champs semenciers de cacaoyers par les loranthaceae dans la localité de Nkoemvone (sud Cameroun). 7795 to the various clones, Phragmanthera capitata was the most abundant Loranthaceae; the level of parasitism of cacao trees is more important at the cacao trees of ...

Report by the AERES on the unit: Reactor Study Department (DER) under the supervision of the establishments and bodies: Atomic Energy and Alternative Energies Commission (CEA); Rapport de l'AERES sur l'unite: Departement d'Etudes des Reacteurs (DER) sous tutelle des etablissements et organismes: CEA

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-02-15

This report is a kind of audit report on a research laboratory, the DER (Departement d'Etudes des Reacteurs, Reactor Study Department) whose activity if focused on four main themes: neutron transport simulation in reactor cores, thermal-hydraulic simulation of reactors, design and safety of innovative reactors, nuclear instrumentation for reactors. The authors discuss an assessment of the whole unit activities in terms of strengths and opportunities, aspects to be improved, risks and recommendations, productions and publications, scientific quality, influence and attractiveness (awards, recruitment capacity, capacity to obtain financing and to tender, participation to international programs), strategy and governance, and project. These same aspects are then discussed and commented for each theme
Decontamination of lead by fusion (1962); Decontamination du plomb par fusion (1962)

Energy Technology Data Exchange (ETDEWEB)

Boutot, P; Giachetto, L; Capitaine, A [Commissariat a l' Energie Atomique, Centre de Production de Plutonium, Marcoule (France). Centre d' Etudes Nucleaires

1962-07-01

Various attempts to decontaminate using mechanical and chemical methods having given questionable results, a fusion method has been developed. The apparatus consists of a propane-heated oven fitted with a steel crucible of 1 400 kg capacity, with two ventilation systems, and with a vacuum gauge for preventing the diffusion of toxic gases. There are three operational controls : 1. On the samples taken before during and after the operation, 2. On the plugs taken from the ingots, 3. On the ingot itself. The continuous sanitary control is done by a radioactive aerosol recorder and by periodic sampling. This decontamination process will be improved, especially as far as the productivity and the safety precautions are concerned. (authors) [French] Divers essais de decontamination par voies mecaniques et chimiques ayant donne des resultats discutables, un procede par fusion a ete mis au point. L'appareil se compose d'un four, chauffe au propane, muni d'un creuset en acier d'une capacite de 1 400 kg, de deux systemes de ventilation et d'un deprimometre afin d'eviter la diffusion de vapeurs nocives. Trois controles d'activite sont effectues: 1. sur des echantillons preleves avant, pendant et apres l'operation, 2. sur des carottages realises sur les lingots, 3. sur le lingot lui-meme. Le controle sanitaire permanent est assure par un enregistreur d'aerosols radioactifs et par des prelevements periodiques. Ce procede de decontamination doit encore etre ameliore, principalement en ce qui concerne la productivite et la securite. (auteurs)
The rate of endophthalmitis after pars plana vitrectomy and its risk factors.

Science.gov (United States)

Tabatabaei, Seyed Ali; Soleimani, Mohammad; Vakili, Hadi; Naderan, Morteza; Lashay, Alireza; Faghihi, Houshang; Yaseri, Mehdi

2018-05-11

To study the incidence of endophthalmitis after pars plana vitrectomy, its causative organisms, and visual acuity outcomes. In this retrospective, comparative study, the medical records of patients with acute-onset postoperative endophthalmitis after pars plana vitrectomy at Farabi Eye Hospital, Tehran, Iran, during a 12-year period between January 2004 and November 2015 were reviewed. To compare the endophthalmitis patients with other cases who underwent pars plana vitrectomy at the same day and also the same operating room, a control group was developed by gathering the data from surgical records. In the present study, the incidence rate of pos- vitrectomy endophthalmitis was 0.04% (16/39783). The organisms identified in aqueous or vitreous cultures (culture positive 44%) included Streptococcus pneumoniae (two patients, 12.5%), Pseudomonas aeruginosa (two patients, 12.5%), fungi (two patients, 12.5%), and Streptococcus viridans (one patient, 6.25%). Visual acuity after treatment for endophthalmitis ranged from light perception (7 eyes) to hand motion (1 eye), and evisceration was performed in 8 eyes (50%). When comparing the cases (patients developing endophthalmitis) and controls (patients with no complications operated in the same day and place of operation with the case group), only not using tamponade showed a statistically significant relation with the occurrence of endophthalmitis (p = 0.034). Our results indicated low incidence of endophthalmitis after pars plana vitrectomy comparable to previous studies which resulted in poor visual acuity. It seems that not using tamponade might increase the risk of endophthalmitis among these patients.
MODELISATION DE LA CINETIQUE CHIMIQUE DANS LA REDUCTION DES OXYDES D4AZOTE PAR DECHARGE COURONNE.

OpenAIRE

MEDJAHDI, Sarah ines

2015-01-01

CE TRAVAIL DE recherche rentre dans le cadre général de modélisation de la réduction des oxydes d'azote . l'utilisation des réacteurs a plasma froid non-thermique généré par des décharges couronnes est actuellement l'une des techniques les puis promettre .ses pour la destruction des oxydes d'azote .en effet , le traitement des gaz pollués par les décharges couronnes est notamment rendu possible par la multiplication des décharges Électriques .
Evaluation of the Stability After Orthodontic Treatment Using PAR Index

Directory of Open Access Journals (Sweden)

Chaitra Ramanathan

2006-01-01

Full Text Available The aim of the present study is to establish the results using the scores obtained from the methodology that was applied for assessing the stability after 2 years post orthodontic treatment and stability in a sample of 69 individuals. After applying PAR index to the collected group of patients, a series of scores were obtained, which were then needed to be evaluated further to establish the results. The scores were evaluated using the nomogram. A comparison was done between the post treatment and the 2 years post treatment PAR weighting scores to determine if the results were stable after orthodontic treatment. The majority of the orthodontic patients were treated to a good standard and that the results appeared to be stable.
Epuration des effluents industriels par électroflottation Belkacem ...

African Journals Online (AJOL)

étudié la séparation de quelques métaux lourds tels que le fer, le nickel, ... the separation of some heavy metals such as iron, nickel, copper, zinc, lead and ... généralement basées sur l'adsorption (par ... Différents essais de concentration en.
L'initiative Agua Limpia para Perú est dirigée par un ancien titulaire ...

International Development Research Centre (IDRC) Digital Library (Canada)

9 juil. 2014 ... Au Pérou, de nombreuses sources d'eau sont contaminées par de ... l'accès à une eau propre et la formation sur l'assainissement, les eaux usées et les ... par AguaSAN Perú aux fins du traitement des eaux (en espagnol).
Insectos parásitos que afectan a loros de Argentina y métodos para su obtención

OpenAIRE

Aramburú, Rosana

2012-01-01

Las aves son parasitadas por una comunidad diversa de artrópodos, que pueden ser la causa principal de morbilidad y mortalidad en pichones y adultos. En este trabajo se brinda información sobre métodos para obtener insectos parásitos, distinguiendo métodos sobre el ave (para parásitos permanentes) y de búsqueda en el nido (para parásitos temporarios). Se ofrecen comentarios sobre algunos de los grupos más importantes de insectos parásitos de loros que se distribuyen en Argentina: piojos masti...
The life of some metallic uranium based fuel elements; Duree de vie de quelques combustibles a base d'uranium metal

Energy Technology Data Exchange (ETDEWEB)

Stohr, J A; Englander, M [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1958-07-01

Description of some theoretical and experimental data concerning the design and most economic preparation of metallic uranium based fuel elements, which are intended to produce an energy of 3 kW days/g of uranium in a thermal reactor, at a sufficiently high mean temperature. Experimental results obtained by testing by analogy or by actually trying out fuel elements obtained by alloying uranium with other metals in proportions such that the resistance to deformation of the alloy produced is much higher than that of pure metallic uranium and that the thermal utilisation factor is only slightly different from that of the uranium. (author) [French] Description de quelques donnees theoriques et experimentales concernant la conception et la preparation la plus economique d'elements combustibles a base d'uranium metallique naturel, destines a degager dans un reacteur thermique une energie de l'ordre de 3 kWj/g d'uranium a une temperature moyenne suffisamment elevee. Resultats experimentaux acquis par tests analogiques ou reels sur combustibles obtenus par alliage de l'uranium avec des elements metalliques en proportions telles que la resistance a la deformation soit bien superieure a celle de l'uranium metal pur et que le facteur propre d'utilisation thermique n ne soit que peu affecte. (auteur)
"It was like reading a detective novel": Using PAR to work together for culture change.

Science.gov (United States)

Fortune, Darla; McKeown, Janet; Dupuis, Sherry; de Witt, Lorna

2015-08-01

Participatory action research (PAR), with its focus on engagement and collaboration, is uniquely suited to enhancing culture change initiatives in dementia care. Yet, there is limited literature of its application to culture change approaches in care settings, and even less in dementia specific care contexts. To address these gaps in the literature, the purpose of this paper is to examine the complexities of a PAR project aimed at changing the culture of dementia care in two diverse dementia care settings, including a long term care (LTC) and community care setting. Drawing from data gathered throughout the PAR process, we unpack the challenges experienced by participants working together to guide culture change within their respective care settings. These challenges include: overextending selves through culture change participation; fluctuating group membership; feeling uncertainty, confusion and apprehension about the process; frustratingly slow process; and seeking diverse group representation in decision making. We also highlight the potential for appreciative inquiry (AI) to be integrated with PAR to guide a process whereby participants involved in culture change initiatives can develop strategies to mitigate challenges they experience. We view the challenges and strategies shared here as being constructive to would-be culture change agents and hope this paper will move others to consider the use of PAR when engaging in culture change initiatives. Copyright © 2015 Elsevier Inc. All rights reserved.
Inhibiting trophoblast PAR-1 overexpression suppresses sFlt-1-induced anti-angiogenesis and abnormal vascular remodeling: a possible therapeutic approach for preeclampsia.

Science.gov (United States)

Zhao, Yin; Zheng, YanFang; Liu, XiaoXia; Luo, QingQing; Wu, Di; Liu, XiaoPing; Zou, Li

2018-03-01

Is it possible to improve vascular remodeling by inhibiting the excessive expression of protease-activated receptor 1 (PAR-1) in trophoblast of abnormal placenta? Inhibition of trophoblast PAR-1 overexpression may promote placental angiogenesis and vascular remodeling, offering an alternative therapeutic approach for preeclampsia. PAR-1 is high-affinity receptor of thrombin. Thrombin increases sFlt-1 secretion in trophoblast via the activation of PAR-1. It is reported that the expression of both thrombin and PAR-1 expression are increased in placentas of preeclampsia patients compared with normal placentas. Trophoblast cells were transfected with PAR-1 short hairpin RNA (shRNA) or PAR-1 overexpression plasmids in vitro. Tube formation assays and a villus-decidua co-culture system were used to study the effect of PAR-1 inhibition on placental angiogenesis and vascular remodeling, respectively. Placentas from rats with preeclampsia were transfected with PAR-1 shRNA to confirm the effect of inhibiting PAR-1 overexpression in placenta. The trophoblast cell line HTR-8/SVneo was transfected with PAR-1 shRNA or PAR-1 overexpression plasmids. After 48 h, supernatant was collected and the level of sFlt-1 secretion was measured by ELISA. Human umbilical cord epithelial cells and a villus-decidua co-culture system were treated with conditioned media to study the effect of PAR-1 inhibition on tube formation and villi vascular remodeling. A preeclampsia rat model was established by intraperitoneal injection of L-NAME. Plasmids were injected into the placenta of the preeclampsia rats and systolic blood pressure was measured on Days 15 and 19. The effect of different treatments was evaluated by proteinuria, placental weights, fetal weights and fetal numbers in study and control groups. The level of serum sFlt-1 in rats with preeclampsia was also measured. Changes in the placenta microvessels were studied by histopathological staining. PAR-1 shRNA inhibited PAR-1 expression and
Le coût par QALY rapporté au PIB (CQP): suggestion d'un nouvel ...

African Journals Online (AJOL)

Le coût par QALY rapporté au PIB (CQP): suggestion d'un nouvel indice économique évaluant l'impact réel du coût du bénéfice des molécules onéreuses en oncologie par rapport aux moyens économique d'un pays.
uPAR Targeted Radionuclide Therapy with 177Lu-DOTA-AE105 Inhibits Dissemination of Metastatic Prostate Cancer

DEFF Research Database (Denmark)

Persson, Morten; Juhl, Karina; Rasmussen, Palle

2014-01-01

The urokinase-type plasminogen activator receptor (uPAR) is implicated in cancer invasion and metastatic development in prostate cancer and provides therefore an attractive molecular target for both imaging and therapy. In this study, we provide the first in vivo data on an antimetastatic effect...... of uPAR radionuclide targeted therapy in such lesions and show the potential of uPAR positron emission tomography (PET) imaging for identifying small foci of metastatic cells in a mouse model of disseminating human prostate cancer. Two radiolabeled ligands were generated in high purity and specific...... value of 100 nM in a competitive binding experiment. In vivo, uPAR targeted radionuclide therapy significantly reduced the number of metastatic lesions in the disseminated metastatic prostate cancer model, when compared to vehicle and nontargeted 177Lu groups (p
Traitement De La Peripneumonie Contagieuse Bovine Par L ...

African Journals Online (AJOL)

Traitement De La Peripneumonie Contagieuse Bovine Par L'oxyteTracycline Longe Action Et Transmission Experimentale de la Maladie A Partir de Bovins Traites. ... Tous les 14 animaux ont séroconverti et l'analyse post-mortem a montré la présence des lésions chroniques dont des séquestres pulmonaires chez 4 d'entre ...
Parasitisme de Dacryodes edulis par le genre Tapinanthus ...

African Journals Online (AJOL)

SARAH

31 août 2013 ... Parasitisme de Dacryodes edulis par le genre. Tapinanthus (Loranthaceae) et répartition de la myrmécofaune associée à Logbessou Plateau. (Douala, Cameroun). Massako F1*, Tchatat M2, Mony R3, Ladoh Yemeda CF1, Dibong SD1,4,5. 1Laboratoire de Biologie et Physiologie des Organismes ...
Solution volumes finis polynomiale par morceaux pour les ...

African Journals Online (AJOL)

Nous présentons dans ce papier un concept de solution volumes finis continue pour des problèmes de diffusion-convection avec des données régulières. Nous comparons dans certains cas particuliers la solution proposée avec la solution volumes finis classiques (qui est une fonction constante par morceaux) et la ...
Cyclanthaceae no estado do Pará, Brasil Cyclanthaceae in Pará State, Brazil

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Eduardo da Silva Leal

2012-12-01

Full Text Available Cyclanthaceae apresenta distribuição exclusiva na região neotropical sendo bem diversificada nas terras baixas das florestas pluviais tropicais, ocorrendo do sul do México até a Mata Atlântica do sul do Brasil. Consistem de ervas terrestres, epífitas, hemiepífitas ou lianas. O tratamento taxonômico de Cyclanthaceae no Pará foi baseado em coleções de herbário, trabalhos de campo e consulta a bibliografia referente à família. Foram registradas 11 espécies: Asplundia altiscandens E.S. Leal, A. fanshawei (Maguire Harling, A. glandulosa (Gleason Harling, A. heteranthera Harling, A. latifrons (Drude Harling, A. schizotepala Harling, A. xiphophylla Harling, Cyclanthus bipartitus Poit. ex A. Rich., Evodianthus funifer (Poit. Lindm., Ludovia lancifolia Brongn. e Thoracocarpus bissectus (Vell. Harling. São apresentadas chave de identiﬁcação, descrições e ilustrações das espécies, além de comentários sobre distribuição geográﬁca, hábitat e período de ﬂoração e frutiﬁcação.Cyclanthaceae is a family with a distribution exclusively in the Neotropics and is well diversified in lowland rainforests, occurring from southern Mexico to the Atlantic Forest of southern Brazil. The family consists of terrestrial herbs, epiphytes, hemiepiphytes and lianas. This taxonomic treatment of the Cyclanthaceae from the state of Pará was based on herbarium specimens, ﬁeldwork, and the literature. Eleven species were recorded: Asplundia altiscandens E.S. Leal, A. fanshawei (Maguire Harling, A. glandulosa (Gleason Harling, A. heteranthera Harling, A. latifrons (Drude Harling, A. schizotepala Harling, A. xiphophylla Harling, Cyclanthus bipartitus Poit. ex A. Rich., Evodianthus funifer (Poit. Lindm., Ludovia lancifolia Brongn. and Thoracocarpus bissectus (Vell. Harling. An identiﬁcation key, descriptions and illustrations of species are presented. Additional information on the geographic distribution, habitat, and ﬂowering and
Study of some ion exchange minerals which can be used in water at high temperature; Etude de quelques echangeurs mineraux utilisables dans l'eau a haute temperature

Energy Technology Data Exchange (ETDEWEB)

Hure, J.; Platzer, R.; Bittel, R. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Fourre, J. [Societe le Carbone Lorraine, 75 - Paris (France); Wey, R. [Faculte des Sciences de Strasbourg, Lab. de Mineralogie, 67 (France)

1958-07-01

these impurities (that is to say capable of de-mineralizing polluted water). This paper describes the preliminary results of the investigation. (author) [French] L'etude de l'utilisation des echangeurs d'ions a haute temperature a ete essentiellement faite en vue de l'epuration de l'eau des reacteurs. On connait l'interet qu'il y a a garder dans un circuit de reacteur de l'eau de tres haute resistivite (plusieurs centaines a quelques millions {omega}.cm): abaissement de la corrosion, abaissement du taux de radiolyse, abaissement de la radioactivite des circuits et canalisations, les elements autres que les constituants de l'eau transportes par celle-ci devenant generalement radioactifs par leur passage au coeur du reacteur. Si la circulation d'eau se fait a des temperatures inferieures a 45 deg. C, les resines echangeuses d'ions organiques utilisees en lit melange resolvent tres bien le probleme de l'epuration en continu. Par contre, pour des temperatures plus elevees surtout au-dessus de 100 deg. C, leur utilisation n'est pas possible, la degradation de ces hauts polymeres etant tres rapide. De meme, l'action des rayonnements, par exemple ceux des produits fixes par les echangeurs d'ions, detruit irremediablement les chaines organiques constituant le squelette de ces echangeurs. Nous avons donc cherche d'es composes pouvant assurer une bonne deionisation de l'eau, mais de structures telles qu'elles ne soient pas deteriorees par l'action de la temperature et des rayonnements. Nous nous sommes particulierement orientes dans trois voies: - echangeurs d'ions naturels a structure minerale (argile du type montmorillonite), - composes mineraux naturels traites pour leur conferer les proprietes d'echangeurs d'ions (charbons actives), - composes mineraux synthetiques (sels tres peu solubles, phosphate et hydroxyde de zirconium et de thorium). Dans ces etudes, nous nous
suPAR remains uninfluenced by surgery in septic patients with bloodstream infection

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Rabensteiner, Jasmin

2016-07-01

Full Text Available Surgical trauma induces activation of the immune system and may cause an increase of inflammatory biomarkers tested postoperatively in septic patients treated for bloodstream infection. The aim of this study was to determine the impact of surgical interventions on the novel sepsis biomarker soluble urokinase plasminogen activator receptor (suPAR and to compare results with those of routine laboratory parameters CRP, PCT, and IL-6 in patients with culture-proven bloodstream infection. Forty-six adult patients with positive blood culture undergoing minor or major surgical intervention were investigated, 12 blood culture positive patients served as control group. Blood was collected 24 hours before and after surgical intervention for determination of the sepsis biomarkers suPAR, CRP, PCT, and IL-6. Within the surgical study cohort, a non-significant increase of suPAR, CRP, and PCT was observed postoperatively ( 0.642; 0.773; 0.087. In contrast, a slight decrease of IL-6 ( 0.599 was observed. A significant correlation was calculated for the pre- and postoperative difference of CRP ( 0.028 and PCT and type of surgical intervention received: after minor surgical intervention only PCT decreased significantly (<0.001, while after major surgical interventions no significant differences were observed for all biomarkers evaluated. In the control group, a significant decrease of CRP ( 0.005 and PCT ( 0.005 was observed. In patients treated adequately for bloodstream infections, postoperative suPAR levels remained uninfluenced of the surgical trauma and might therefore be a reliable parameter for postoperative infectious monitoring. After minor surgical intervention, PCT seems to be the most reliable parameter.
Equilibrios de óxido-reducción. Variación del potencial de un par con el pH. Reacción entre el par dicromato-cromo y yodo-yoduro. Problema interactivo.

OpenAIRE

Milla González, Miguel

2015-01-01

El potencial redox de los oxoaniones oxidantes varía en función de la concentración de protones del medio. Eso le ocurre al par dicromato-cromo(III). Sin embargo, el potencial del par yodo-yoduro es formalmente independiente del pH. En este ejercicio es necesario calcular el pH para el que la reacción entre ambos pares no va teóricamente en ningún sentido.

Evaluation of Passive Autocatalytic Recombiner (PAR) Implementation in a Konvoi NPP Containment Type

Energy Technology Data Exchange (ETDEWEB)

Lopez-Alonso, E.; Papini, D.; Jimenez, G.

2015-07-01

The evaluation of Passive Autocatalytic Recombiner (PAR) implementation has been developed under the methodology extracted from the IAEA document, analysing the size, location and number of the PARs capable to minimize the combustion risk, which arises from a hydrogen release generated during a severe accident and its distribution in containment building. A detailed three-dimensional model of Konvoi (PWR) containment with GOTHIC 8.1 code was used for the simulations. The hydrogen preferential pathways and the accumulation points were studied and identified on the basis of a base case scenario without any mitigation measure. The PAR configuration offers an improvement in the chosen accidental scenario; decreasing the possibility of hydrogen combustion and leading to concentration values below the flammability limit (hydrogen concentration below 7%), in all the containment compartments at the end of the transient. Furthermore, from the analysis, it is concluded that the time required to reach hydrogen concentrations below the combustion limit is considerably reduced. (Author)
Indications and visual outcome of first hundred pars plana ...

African Journals Online (AJOL)

Objective: To review the indications and visual outcome of the first one hundred pars plana vitrectomies performed at the newly established surgical retina unit of Makkah Specialist Eye Hospital, Kano, Kano State, Nigeria. Materials and Methods: Aretrospective chart review was performed. Data recorded from the patient ...
Aspects of Reactor Physics Research at the Victoria University of Manchester; Quelques Aspects des Experiences de Physique des Reacteurs a l'Universite Victoria de Manchester; Aspekty ehksperimental'nykh issledovanij po fizike reaktorov v universitete viktorii v manchestere; Trabajos de Fisica Experimental con Reactores Efectuados en la Universidad Victoria de Manchester

Energy Technology Data Exchange (ETDEWEB)

Harris, M. J.; Walton, D. G. [Victoria University of Manchester (United Kingdom)

1964-02-15

constructed. Its mechanical design gives considerable flexibility so that, for instance, measurements parallel and perpendicular to the fuel rods are greatly facilitated. A programme of steady-state measurements is under way. Future work is outlined, and includes fine structure measurements, voidage effects and pulsed neutron studies. (author) [French] Le Departement du genie nucleaire de l'Universite de Manchester a ete cree en 1959. Depuis lors, les etudes post-universitaires de physique des reacteurs se sont progressivement developpees et elargies en partant virtuellement de zero; les travaux ont porte sur les reseaux a eau ordinaire et notamment sur les experiences exponentielles a uranium naturel et a eau ordinaire alimentees par un accelerateur de particules. Les auteurs passent en revue les travaux effectues, etudient les resultats obtenus, donnent des apercus sur les recherches futures et illustrent leur expose par la description de diverses techniques experimentales adoptees a Manchester, qui sont peu onereuses et ne necessitent qu'un personnel reduit. Les principaux sujets de recherches sont decrits ci-apres. Les auteurs ont etudie la diffusion des neutrons dans l'eau ordinaire en employant successivement la methode de la source puisee et celle de la source stationnaire. Avec la premiere methode, ils se sont astreints a faire une analyse harmonique complete, au point d'etudier effectivement les modes superieurs alors que, par le passe, ont cherchait seulement a les eliminer. Au moyen de la methode de la source stationnaire, ils ont cherche surtout a eliminer tous les effets dus a la dimension de la source finie et du detecteur, al'activation par resonance, a la perturbation du flux, etc. Ils discutent et comparent les resultats de ces deux etudes. Le memoire decrit ensuite une mesure tres precise des sections efficaces d'absorption, egalement en cours, par la methode des neutrons puises, en prenant soin d'eliminer les effets harmoniques et autres, generateurs d
Stress reactions involving the pars interarticularis in young athletes

Energy Technology Data Exchange (ETDEWEB)

Jackson, D.W.; Wiltse, L.L.; Dingeman, R.D.; Hayes, M.

A stress reaction involving the pars interarticularis of the lumbar spine was confirmed in seven young athletes with a positive technetium pyrophosphate bone scan. No pars defects were detectable on their lumbosacral roentgenograms, which included oblique views. The return to normal levels of radioactive uptake on repeat bone scans correlated closely with their clinical course. If the bony reaction is recognized early, it may heal at a subroentgenographic level and prevent the development of lumbar spondylolysis. These early lesions usually show unilateral increased uptake at one lumbar level on the bone scan and, initially, the athlete localizes the pain to the corresponding unilateral lumbar paraspinous area. The ''one-legged hyperextension test'' is positive on the ipsilateral side and aggravates the pain. Treatment consists of avoiding the aggravating activities and resting. The average time for return to pain-free competition was 7.3 months. These developing defects may be the source of considerable prolonged disability in the young athlete, particularly if undiagnosed and untreated.
Stress reactions involving the pars interarticularis in young athletes

International Nuclear Information System (INIS)

Jackson, D.W.; Wiltse, L.L.; Dingeman, R.D.; Hayes, M.

1981-01-01

A stress reaction involving the pars interarticularis of the lumbar spine was confirmed in seven young athletes with a positive technetium pyrophosphate bone scan. No pars defects were detectable on their lumbosacral roentgenograms, which included oblique views. The return to normal levels of radioactive uptake on repeat bone scans correlated closely with their clinical course. If the bony reaction is recognized early, it may heal at a subroentgenographic level and prevent the development of lumbar spondylolysis. These early lesions usually show unilateral increased uptake at one lumbar level on the bone scan and, initially, the athlete localizes the pain to the corresponding unilateral lumbar paraspinous area. The ''one-legged hyperextension test'' is positive on the ipsilateral side and aggravates the pain. Treatment consists of avoiding the aggravating activities and resting. The average time for return to pain-free competition was 7.3 months. These developing defects may be the source of considerable prolonged disability in the young athlete, particularly if undiagnosed and untreated
Modification de la surface du cuivre par implantation ionique par source plasma (IISP): applications à l’érosion cathodique dans les systèmes à arcs

OpenAIRE

Roy, F

2006-01-01

L’érosion cathodique est un phénomène bien connu qui limite la durée de vie de l’électrode négative dans les systèmes à arcs. Dans le présent mémoire, nous avons tenté de voir si la formation de précipités nanométriques d’oxyde de cuivre pouvait réduire l’érosion cathodique nécessaire au maintien de l’arc en mode thermo-champ (T-F). Les dits précipités ont été produits par implantation ionique par source plasma (IISP). Avec l’aide de techniques de caractérisation telle que la microscopie à fo...
Apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma.

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Ramaprasada Rao Kotipatruni

Full Text Available Medulloblastoma is a highly invasive cancer of central nervous system diagnosed mainly in children. Matrix metalloproteinase-9 (MMP-9 and urokinase plasminogen activator receptor (uPAR are over expressed in several cancers and well established for their roles in tumor progression. The present study is aimed to determine the consequences of targeting these molecules on medulloblastoma progression.Radiation is one of the foremost methods applied for treating cancer and considerable evidence showed that radiation elevated uPAR and MMP-9 expression in medulloblastoma cell. Therefore efforts are made to target these molecules in non-irradiated and irradiated medulloblastoma cells. Our results showed that siRNA-mediated knockdown of uPAR and MMP-9, either alone or in combination with radiation modulated a series of events leading to apoptosis. Down regulation of uPAR and MMP-9 inhibited the expression of anti-apoptotic molecules like Bcl-2, Bcl-xL, survivin, XIAP and cIAPI; activated BID cleavage, enhanced the expression of Bak and translocated cyctochrome C to cytosol. Capsase-3 and -9 activities were also increased in uPAR- and MMP-9-downregulated cells. The apoptosis induced by targeting MMP-9 and uPAR was initiated by inhibiting epidermal growth factor receptor (EGFR mediated activation of STAT3 and NF-κB related signaling molecules. Silencing uPAR and MMP-9 inhibited DNA binding activity of STAT3 and also reduced the recruitment of STAT3 protein at the promoter region of Bcl-2 and survivin genes. Our results suggest that inhibiting uPAR and MMP-9 reduced the expression of anti-apoptotic molecules by inactivating the transcriptional activity of STAT3. In addition, treating pre-established medulloblastoma with siRNAs against uPAR and MMP-9 both alone or in combination with radiation suppressed uPAR, MMP-9, EGFR, STAT3 expression and induced Bak activation leading to apoptosis.Taken together, our results illustrated that RNAi mediated targeting of
Améliorer l'immunité innée des macrophages par la modulation des ...

International Development Research Centre (IDRC) Digital Library (Canada)

Les maladies causées par une infection guérissent le plus souvent grâce à une réaction immunitaire déclenchée par des cellules pour éliminer les agents étrangers. Ces cellules comprennent les macrophages, le principal type de cellule qui élimine les agents infectieux au cours d'un processus appelé phagocytose, ...
Tuberculose lymphonodale cervicale chez les enfants vaccines par ...

African Journals Online (AJOL)

La tuberculose ganglionnaire cervicale est une localisation extrapulmonaire relativement fréquente chez l'enfant. Elle pose essentiellement des difficultés de prévention. L'objectif de ce travail est d'étudier les particularités diagnostiques et thérapeutiques chez des enfants vaccinés par le BCG. Matériel et méthodes: Nôtre ...
Candido: Uma Leitura Paródica de Candide

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Maria Gloria Cusumano Mazzi

2010-12-01

Full Text Available O presente artigo estuda a leitura paródica que Leonardo Sciascia (1921-1989 faz de Voltaire (1694-1778 mediante o cotejo das obras: o hipertexto Candido ovvero Un sogno fatto in Sicilia (1977 e o hipotexto Candide ou l’optimisme (1759. Apresenta ainda outra possibilidade de leitura, ou seja, Candido como metáfora da própria intertextualidade.
Manufactering of par-fried french-fries. Part 3: a blueprint to predict the maximum production yield

NARCIS (Netherlands)

Somsen, D.J.; Capelle, A.; Tramper, J.

2004-01-01

Very little research on the production yield of par-fried French-fries has been reported in the literature. This paper bridges the knowledge gap and outlines the development of a model to predict the maximum production yield of par-fried French-fries. This yield model can be used to calculate the
parámetros en híbridos de populus

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O. S. Vallejos-Barra

2007-01-01

Full Text Available La variable diámetro a la altura del pecho, medido a 1.3 m desde el suelo (DAP es lognormal si log(DAP-θ se distribuye normalmente. Para simplificar el ajuste de esta función de densidad de probabilidad (fdp se supone que el parámetro de localización (θ es cero en híbridos de Populus; sin embargo, en algunos casos esta simplificación no asegura el mejor ajuste de la fdp, incidiendo en la representación de la estructura horizontal de los híbridos. El objetivo de la investigación fue calcular el parámetro θ que proporcione el mejor ajuste de la fdp lognormal del DAP en los híbridos I-488 e I-63/51. Para este cálculo se utilizó un algoritmo de búsqueda binaria, que minimizó el estadístico Dn de la prueba de Kolmogorov-Smirnov. 38 % de las parcelas presentó un parámetro θ distinto de cero, originando una mejoría del valor de probabilidad (P entre 0.02 y 55.4 %. Se hizo un análisis de varianza no paramétrico de la variable √n * Dn, ya que la variable original y múltiples transformaciones no permitieron aceptar los supuestos del análisis paramétrico. El tipo de ajuste presentó diferencias estadísticas altamente significativas con un valor de 17.1 (P0.800 y las edades un valor de 11.2 (P>0.260.
La preuve par le nombre

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Hélène Verdier

2012-04-01

Full Text Available S’il en était besoin, la question des usages et de la finalité des résultats de l’inventaire général pourrait être abordée par le nombre : nombre d’œuvres répertoriées, de communes inventoriées, de clichés photographiques réalisés, de dossiers, de consultations des notices dans les bases de données… Les additions aujourd’hui sont éloquentes, mais elles laissent dans l’ombre le rôle de l’inventaire qui, en mettant en œuvre une démarche systématique de connaissance, participe à l’ identificatio...
EXAME PRÉ-PARTICIPAÇÃO ESPORTIVA E O PAR-Q, EM PRATICANTES DE ACADEMIAS

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Ingryd Maturo Andreazzi

Full Text Available RESUMO Introdução: O Brasil tem o maior número de academias do mundo (cerca de 20 mil e aproximadamente de 3,6 milhões de brasileiros praticam atividade física nesses locais. Torna-se necessária uma padronização da triagem de praticantes de academia a fim de reduzir ao máximo o risco de morte súbita e outras morbidades associadas ao exercício físico. Objetivo: Comparar o Questionário de Prontidão para Atividade Física (Physical Activity Readiness Questionnaire, PAR-Q com o exame físico pré-participação esportiva na detecção de risco à saúde em praticantes de academia. Métodos: Estudo transversal, realizado nas cidades de São Bernardo do Campo e Guarulhos, São Paulo, Brasil. Foram avaliados 50 indivíduos, de ambos os sexos, entre 18 e 35 anos que iniciariam atividades físicas. Realizou-se anamnese, exame físico geral e ortopédico, teste de flexibilidade e o PAR-Q. As variáveis quantitativas foram analisadas pela média, desvio padrão e porcentagens. A comparação das variáveis contínuas com distribuição normal foi feita pelo teste t e a comparação das variáveis qualitativas, pelo teste do qui-quadrado ou teste exato de Fisher. Fixou-se em 5% a hipótese de nulidade. Resultados: O PAR-Q foi positivo em 20% dos entrevistados, assemelhando-se aos dados da anamnese, em que 28% relataram alguma doença. O questionário teve associação positiva em indivíduos que faziam uso de medicação (p = 0,001, história familiar de hipertensão arterial sistêmica (p = 0,001 e antecedentes de cirurgia (p = 0,03. Os participantes com PAR-Q positivo tiveram os maiores valores de índice de massa corpórea, pressão arterial sistólica e diastólica, mas a diferença não foi estatisticamente significante. O PAR-Q não foi capaz detectar morbidades clínicas como: asma (8%, dislipidemia (4%, hipotireoidismo (2%, tabagismo (8% e cirurgias prévias (40%. O exame abdominal e cardiopulmonar estava alterado em quatro
Row orientation effect on UV-B, UV-A and PAR solar irradiation components in vineyards at Tuscany, Italy

Science.gov (United States)

Grifoni, D.; Carreras, G.; Zipoli, G.; Sabatini, F.; Dalla Marta, A.; Orlandini, S.

2008-11-01

Besides playing an essential role in plant photosynthesis, solar radiation is also involved in many other important biological processes. In particular, it has been demonstrated that ultraviolet (UV) solar radiation plays a relevant role in grapevines ( Vitis vinifera) in the production of certain important chemical compounds directly responsible for yield and wine quality. Moreover, the exposure to UV-B radiation (280-320 nm) can affect plant-disease interaction by influencing the behaviour of both pathogen and host. The main objective of this research was to characterise the solar radiative regime of a vineyard, in terms of photosynthetically active radiation (PAR) and UV components. In this analysis, solar spectral UV irradiance components, broadband UV (280-400 nm), spectral UV-B and UV-A (320-400 nm), the biological effective UVBE, as well as the PAR (400-700 nm) component, were all considered. The diurnal patterns of these quantities and the UV-B/PAR and UV-B/UV-A ratios were analysed to investigate the effect of row orientation of the vineyard in combination with solar azimuth and elevation angles. The distribution of PAR and UV irradiance at various heights of the vertical sides of the rows was also studied. The results showed that the highest portion of plants received higher levels of daily radiation, especially the UV-B component. Row orientation of the vines had a pronounced effect on the global PAR received by the two sides of the rows and, to a lesser extent, UV-A and UV-B. When only the diffused component was considered, this geometrical effect was greatly attenuated. UV-B/PAR and UV-A/PAR ratios were also affected, with potential consequences on physiological processes. Because of the high diffusive capacity of the UV-B radiation, the UV-B/PAR ratio was significantly lower on the plant portions exposed to full sunlight than on those in the shade.
Situation des personnes transgenres par rapport au VIH/IST en Suisse : rapid assessment

OpenAIRE

Bize, R.; Koutaissoff, D.; Dubois-Arber, F.

2013-01-01

Ce rapport permet d'identifier le sous-groupe des personnes transgenres pratiquant ou ayant pratiqué le travail du sexe comme une population clairement exposée à un risque notoirement élevé d'infection par le VIH et les IST. L'ampleur rapportée du phénomène justifie pleinement l'inclusion de cette population dans le dispositif de surveillance comportementale du VIH et des autres IST, mais également la réalisation urgente d'actions de prévention communautaire. Par contre, il ne nous permet pas...
Incorporating GOES Satellite Photosynthetically Active Radiation (PAR) Retrievals to Improve Biogenic Emission Estimates in Texas

Science.gov (United States)

Zhang, Rui; White, Andrew T.; Pour Biazar, Arastoo; McNider, Richard T.; Cohan, Daniel S.

2018-01-01

This study examines the influence of insolation and cloud retrieval products from the Geostationary Operational Environmental Satellite (GOES) system on biogenic emission estimates and ozone simulations in Texas. Compared to surface pyranometer observations, satellite-retrieved insolation and photosynthetically active radiation (PAR) values tend to systematically correct the overestimation of downwelling shortwave radiation in the Weather Research and Forecasting (WRF) model. The correlation coefficient increases from 0.93 to 0.97, and the normalized mean error decreases from 36% to 21%. The isoprene and monoterpene emissions estimated by the Model of Emissions of Gases and Aerosols from Nature are on average 20% and 5% less, respectively, when PAR from the direct satellite retrieval is used rather than the control WRF run. The reduction in biogenic emission rates using satellite PAR reduced the predicted maximum daily 8 h ozone concentration by up to 5.3 ppbV over the Dallas-Fort Worth (DFW) region on some days. However, episode average ozone response is less sensitive, with a 0.6 ppbV decrease near DFW and 0.3 ppbV increase over East Texas. The systematic overestimation of isoprene concentrations in a WRF control case is partially corrected by using satellite PAR, which observes more clouds than are simulated by WRF. Further, assimilation of GOES-derived cloud fields in WRF improved CAMx model performance for ground-level ozone over Texas. Additionally, it was found that using satellite PAR improved the model's ability to replicate the spatial pattern of satellite-derived formaldehyde columns and aircraft-observed vertical profiles of isoprene.
Diversidade de Arctiinae (Lepidoptera, Arctiidae em área alterada em Altamira, Amazônia Oriental, Pará, Brasil Diversity of Arctiinae (Lepidoptera, Arctiidae in disturbed area at Altamira, Eastern Amazon, Pará, Brazil

Directory of Open Access Journals (Sweden)

José Augusto Teston

2010-01-01

Full Text Available Este trabalho avaliou a fauna de Arctiinae em Altamira, Pará, numa área com forte ação antrópica, por meio de armadilhas luminosas, com capturas de duas noites a cada fase de lua nova por mês, no período de dezembro de 2007 a novembro de 2008. Na avaliação foram utilizados os parâmetros: riqueza, abundância, constância, índices de diversidade e uniformidade de Shannon (H’ e E’ e Brillouin (H e E, dominância de Berger-Parker (BP. As estimativas de riqueza foram feitas através dos procedimentos não paramétricos, “Bootstrap”, “Chao 1”, “Chao 2”, “Jackknife 1”, “Jackknife 2” e “Michaelis-Mentem”. Foram capturados 420 espécimes pertencentes a 64 táxons de Arctiinae, sendo 19 espécies registradas pela primeira vez no estado do Pará. Os valores dos parâmetros analisados para todo o período foram: H’= 4,69, E’= 0,781, H= 4,37, E= 0,732 e BP= 0,183. Durante o período menos chuvoso (junho-novembro foram encontrados os valores mais significativos para todos os parâmetros analisados. No período mais chuvoso (dezembro-maio foram encontrados os mais significativos percentuais de similaridade entre os meses. Os estimadores previram o encontro de mais espécies, entre 18,7% a 60,9%.This work evaluates the Arctiinae fauna in Altamira, Pará, in an area with strong human pressure, using light-traps during two nights at each stage of the new moon each month, from December 2007 to November 2008. The evaluation parameters were: richness, abundance, constancy, diversity index and evenness (Shannon H ‘and E’ and Brillouin (H and E, dominance of Berger-Parker (BP. The richness estimatives were made by means of non-parametric procedures, Bootstrap, Chao 1, Chao 2, Jackknife 1, Jackknife 2 and Michaelis-Mentem. We captured 420 specimens belonging to 64 species of Arctiinae, and 19 species recorded for the first time in the state of Pará. The values of the parameters analyzed for the total period were: H �
Glaucoma de ángulo abierto posterior a la vitrectomía pars plana

Directory of Open Access Journals (Sweden)

Kenia Galindo Reymond

Full Text Available Con este trabajo nos proponemos revisar las evidencias científicas relacionadas con la aparición del glaucoma de ángulo abierto posterior a la vitrectomía pars plana. Se revisaron las evidencias científicas relacionadas con la aparición del glaucoma de ángulo abierto posterior a la cirugía de vitrectomía pars plana. Para la investigación documental se examinaron los artículos de la temática indexados en las bases de datos Pubmed, Pubmed Central y Scielo, que correspondieron a los descriptores DeCs-MeSH: glaucoma de ángulo abierto y vitrectomía pars plana. En la búsqueda de avanzada se utilizó el booleano AND y la restricción de tiempo entre los años 2004 y 2014. De los 38 artículos identificados, se desecharon 16 por no tenerse acceso íntegro al documento. El tratamiento de los datos se realizó mediante el análisis de contenido de tipo directo. Los mecanismos patológicos que causan glaucoma de ángulo abierto posterior a la vitrectomía pars plana son múltiples y complejos. La hipótesis del daño por estrés oxidativo en las celdas de la malla trabecular y su repercusión en la salida del humor acuoso, tiene un sustento científico en su patogenia que la hace plausible. El tratamiento para controlar la hipertensión ocular en estos pacientes después de la vitrectomía es individualizado; puede transitar desde el tratamiento médico y hasta el uso de técnicas quirúrgicas simples o complejas en algunos casos. Aún no se han esclarecido los mecanismos fisiopatológicos del glaucoma de ángulo abierto posterior a la vitrectomía pars plana, por lo que son necesarias nuevas investigaciones sobre el tema.
Screening of phytochemicals against protease activated receptor 1 (PAR1), a promising target for cancer.

Science.gov (United States)

Kakarala, Kavita Kumari; Jamil, Kaiser

2015-02-01

Drug resistance and drug-associated toxicity are the primary causes for withdrawal of many drugs, although patient recovery is satisfactory in many instances. Interestingly, the use of phytochemicals in the treatment of cancer as an alternative to synthetic drugs comes with a host of advantages; minimum side effects, good human absorption and low toxicity to normal cells. Protease activated receptor 1 (PAR1) has been established as a promising target in many diseases including various cancers. Strong evidences suggest its role in metastasis also. There are no natural compounds known to inhibit its activity, so we aimed to identify phytochemicals with antagonist activity against PAR1. We screened phytochemicals from Naturally Occurring Plant-based Anticancer Compound-Activity-Target database (NPACT, http://crdd.osdd.net/raghava/npact/ ) against PAR1 using virtual screening workflow of Schrödinger software. It analyzes pharmaceutically relevant properties using Qikprop and calculates binding energy using Glide at three accuracy levels (high-throughput virtual screening, standard precision and extra precision). Our study led to the identification of phytochemicals, which showed interaction with at least one experimentally determined active site residue of PAR1, showed no violations to Lipinski's rule of five along with predicted high human absorption. Furthermore, structural interaction fingerprint analysis indicated that the residues H255, D256, E260, S344, V257, L258, L262, Y337 and S344 may play an important role in the hydrogen bond interactions of the phytochemicals screened. Of these residues, H255 and L258 residues were experimentally proved to be important for antagonist binding. The residues Y183, L237, L258, L262, F271, L332, L333, Y337, L340, A349, Y350, A352, and Y353 showed maximum hydrophobic interactions with the phytochemicals screened. The results of this work suggest that phytochemicals Reissantins D, 24,25-dihydro-27-desoxywithaferin A, Isoguaiacin

L’octroi de crédits aux femmes entrepreneuses libanaises par les banquiers : le cas du dispositif Kafalat

Directory of Open Access Journals (Sweden)

Inaya Wahidi

2016-03-01

Full Text Available L’accès au crédit bancaire sans garantie est quasi impossible au Liban, d’où le dispositif Kafalat qui représente une solution face à cette difficulté. Selon la littérature, l’entrepreneuriat des femmes souffre de discrimination par rapport aux hommes quant à l’octroi de crédits bancaires. Notre objectif est d’essayer de voir dans quelle mesure cette situation existe au Liban. L’étude exploratoire conduite par entretiens semi-directifs auprès des banquiers exclusivement fournit les premiers éléments sur le profil de ces femmes entrepreneuses libanaises et sur la discrimination éventuelle qui pourrait exister du fait de leur sexe pour l’obtention de crédits bancaires. Les résultats semblent montrer que les banquiers ne font pas de distinction entre les entrepreneurs hommes ou femmes, même si les entrepreneuses ont peut-être moins d’informations concernant les garanties offertes par le dispositif Kafalat et sont souvent soutenues par leur mari qui accepte une hypothèque comme garantie du crédit demandé par leur femme ou qui passe par leur femme pour obtenir le crédit nécessaire au développement de leur propre entreprise.
Análisis de parámetros objetivos y subjetivos en Pre-Amplificadores de Audio

Directory of Open Access Journals (Sweden)

Javier A. Beltrán Bríñez

2014-03-01

Full Text Available El siguiente artículo explica los resultados de las mediciones en cinco (5 diferentes pre-amplificadores, entre estado sólido y válvulas al vacío, de parámetros objetivos de THD –Análisis de Fourier- y función de transferencia, y parámetros subjetivos de calidez y brillo, en una muestra no probabilística de expertos con ingenieros de grabación que cuentan con una experiencia entre quince (15 y veinticinco (25 años, con el fin de encontrar una correspondencia directa entre estos parámetros y determinar qué elementos electrónicos están relacionados con la percepción auditiva de calidez y brillo en una grabación realizada con estos dispositivos.
Association entre le travail par quarts et l’obésité chez les hommes dans le nord-est de l’Ontario

Directory of Open Access Journals (Sweden)

Anne Grundy

2017-01-01

Full Text Available Introduction : Même si certaines études suggèrent une association entre le travail par quarts et l’obésité, peu sont fondées sur la population ou tiennent compte de divers horaires de travail par quarts. L’obésité étant associée à plusieurs problèmes de santé chroniques, il est important de comprendre quelles formes de travail par quarts ont une incidence sur elle et d’effectuer des travaux permettant d’évaluer de façon plus détaillée l’exposition au travail par quarts. Méthodologie : Au moyen d’une régression logistique polytomique multivariée, nous avons étudié l’association entre le travail par quarts (de soir ou nuit, par quarts ou autre type de rotation et le surpoids et l’obésité, en fonction d’une mesure transversale de l’indice de masse corporelle chez 1 561 hommes. Ces hommes avaient déjà servi de témoins dans une étude cas-témoins sur le cancer de la prostate menée dans le nord-est de l’Ontario de 1995 à 1999. Nous avons obtenu l’information sur leurs antécédents de travail (notamment sur le travail par quarts, leur taille et leur poids à partir de données autodéclarées recueillies par questionnaire. Résultats : Nous avons observé une association entre le fait d’avoir déjà travaillé par quarts (par opposition au fait de n’avoir jamais travaillé par quarts et le surpoids (RC [rapport de cotes] = 1,34; IC [intervalle de confiance] à 95 % : 1,05 à 1,73 ainsi que l’obésité (RC = 1,57; IC à 95 % : 1,12 à 2,21. Nous avons également observé des associations statistiquement non significatives avec le fait d’avoir déjà travaillé (par opposition au fait de n’avoir jamais travaillé de façon permanente selon un quart de soir ou de nuit. Nous avons par ailleurs observé une tendance à la hausse statistiquement significative en ce qui concerne le risque de surpoids et d’obésité en fonction de la durée du travail par quarts. Conclusion : Tant l�
Urokinase-type plasminogen activator receptor (uPAR), tissue factor (TF) and epidermal growth factor receptor (EGFR)

DEFF Research Database (Denmark)

Christensen, Anders; Kiss, Katalin; Lelkaitis, Giedrius

2017-01-01

Background: Tumor-specific biomarkers are a prerequisite for the development of targeted imaging and therapy in oral squamous cell carcinoma (OSCC). urokinase-type Plasminogen Activator Receptor (uPAR), Tissue Factor (TF) and Epidermal Growth Factor Receptor (EGFR) are three biomarkers that exhib...... with a reduced survival. uPAR seems to be a prognostic biomarker in oral cancer....
Les Brulures Electriques par Haut Voltage - A Propos de 10 Cas

Science.gov (United States)

Belmir, R.; Fejjal, N.; El Omari, M.; El Mazouz, S.; Gharib, N.; Abassi, A.; Belmahi, A.

2008-01-01

Summary Les accidents électriques par haute tension (AEHT) provoquent des brûlures profondes par effet Joule le long des axes vasculo-nerveux entre les points d'entrée et de sortie, qui sont le siège de lésions délabrantes. Les Auteurs rapportent une série de dix cas d'AEHT admis au service de chirurgie réparatrice et de brûlés de l'Hôpital Ibn Sina de Rabat à travers laquelle ils étudient les caractéristiques épidémiologiques, cliniques et thérapeutiques. Tous les patients étaient des adultes de sexe masculin dont l'âge moyen était de 31 ans. Dans 70% des cas, ces brûlures étaient secondaires à un contact avec les distributeurs d'électricité avec une surface brûlée inférieure à 20%. Le traitement des lésions électrothermiques a nécessité des interventions itératives avec amputation des segments de membres nécrosés dans 70% des cas, dont les suites étaient marquées par des séquelles fonctionnelles invalidantes. La prévention des AEHT, en particulier pour les accidents du travail au sein des professions exposées, reste fondamentale. PMID:21991124
Galectin-3 facilitates cell motility in gastric cancer by up-regulating protease-activated receptor-1 (PAR-1 and matrix metalloproteinase-1 (MMP-1.

Directory of Open Access Journals (Sweden)

Seok-Jun Kim

Full Text Available BACKGROUND: Galectin-3 is known to regulate cancer metastasis. However, the underlying mechanism has not been defined. Through the DNA microarray studies after galectin-3 silencing, we demonstrated here that galectin-3 plays a key role in up-regulating the expressions of protease-activated receptor-1 (PAR-1 and matrix metalloproteinase-1 (MMP-1 PAR-1 thereby promoting gastric cancer metastasis. METHODOLOGY/PRINCIPAL FINDINGS: We examined the expression levels of Galectin-3, PAR-1, and MMP-1 in gastric cancer patient tissues and also the effects of silencing these proteins with specific siRNAs and of over-expressing them using specific lenti-viral constructs. We also employed zebrafish embryo model for analysis of in vivo gastric cancer cell invasion. These studies demonstrated that: a galectin-3 silencing decreases the expression of PAR-1. b galectin-3 over-expression increases cell migration and invasion and this increase can be reversed by PAR-1 silencing, indicating that galectin-3 increases cell migration and invasion via PAR-1 up-regulation. c galectin-3 directly interacts with AP-1 transcriptional factor, and this complex binds to PAR-1 promoter and drives PAR-1 transcription. d galectin-3 also amplifies phospho-paxillin, a PAR-1 downstream target, by increasing MMP-1 expression. MMP-1 silencing blocks phospho-paxillin amplification and cell invasion caused by galectin-3 over-expression. e Silencing of either galectin-3, PAR-1 or MMP-1 significantly reduced cell migration into the vessels in zebrafish embryo model. f Galectin-3, PAR-1, and MMP-1 are highly expressed and co-localized in malignant tissues from gastric cancer patients. CONCLUSIONS/SIGNIFICANCE: Galectin-3 plays the key role of activating cell surface receptor through production of protease and boosts gastric cancer metastasis. Galectin-3 has the potential to serve as a useful pharmacological target for prevention of gastric cancer metastasis.
Estradiol attenuates EGF-induced rapid uPAR mobilization and cell migration via the G-protein-coupled receptor 30 in ovarian cancer cells

DEFF Research Database (Denmark)

Henic, Emir; Noskova, Vera; Høyer-Hansen, Gunilla

2009-01-01

: rapid mobilization of uPAR from detergent-resistant domains, increased mRNA, and decreased degradation. G-protein-coupled receptor 30 (GPR30) is a newly identified membrane estrogen receptor (ER).The objective of this study was to explore the effects of 17beta-estradiol (E(2)) on uPAR expression...... for ERalpha, and quantitative polymerase chain reaction. Estradiol attenuates the stimulatory effect of EGF on cell migration and uPAR expression. Specifically, E(2) reduces the very rapid increase of detergent extractable uPAR, which occurs within minutes of EGF stimulation and probably represents...... agonist G1, mimicked the effect of E(2) on uPAR expression and cell migration. OVCAR-3 cells express mRNA for GPR30.Estradiol attenuates EGF-induced mobilization of ligated uPAR from detergent-resistant domains and subsequent migration in ovarian cancer cells. The response to various ER ligands indicates...
Urokinase-type plasminogen activator receptor (uPAR) expression is associated with T-stage and survival in urothelial carcinoma of the bladder

DEFF Research Database (Denmark)

Dohn, Line Hammer; Illemann, Martin; Høyer-Hansen, Gunilla

2015-01-01

OBJECTIVES: To evaluate the expression-and localization pattern of the urokinase-type plasminogen activator receptor (uPAR), focusing on its clinical implications in patients with urothelial neoplasia of the bladder treated with radical cystectomy. uPAR is a central molecule in tissue remodeling...... during cancer invasion and metastasis and is an established prognostic marker in cancer. The expression and localization of uPAR and its prognostic significance is only limitedly investigated in urothelial bladder neoplasia. MATERIALS AND METHODS: The expression-and localization pattern of u......PAR was investigated in formalin-fixed paraffin-embedded tumor tissue from 149 patients treated with radical cystectomy between 1988 and 2005. uPAR expression was determined by immunohistochemistry and scored as either negative or positive. Separate values were obtained for cancer cells, macrophages...
Metastatic breast cancer to the liver with hepatoid features and Hep Par 1 antibody positive mimicking hepatocellular carcinoma.

Science.gov (United States)

Affleck, Authur; Lyman, William B; Jacobs, W Carl; Livasy, Chad A; Martinie, John B; Iannitti, David A; Vrochides, Dionisios

2018-05-09

The hepatocyte paraffin 1 antibody (Hep Par 1) has a high positive predictive value for differentiating hepatocellular carcinoma from cholangiocarcinoma and metastatic carcinoma. 1 We report a case of metastatic breast cancer to the liver with hepatoid histology and strong positive staining for Hep Par 1 mimicking hepatocellular carcinoma. To our knowledge, primary breast carcinoma staining Hep Par 1 positive has not been reported in the setting of hepatic metastasis. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
Parálisis del músculo oblicuo superior atípica

Directory of Open Access Journals (Sweden)

Pedro Daniel Castro Pérez

Full Text Available Las paresias y parálisis oculomotoras implican todos aquellos procesos susceptibles de producir un déficit parcial o total de los movimientos del globo ocular. La lesión puede estar en cualquier parte del sistema oculomotor que incluye la corteza cerebral, el tronco cerebral, nervios, placa neuromuscular y del propio músculo. Las paresias y/o parálisis del músculo oblicuo superior o IV par craneal constituye una de las más frecuentes en la práctica médica estrabológica, puede ser de etiología congénita o adquirida, se caracteriza por hipertropía que aumenta con la inclinación de la cabeza hacia el hombro del lado del ojo afectado (signo de Bielschowsky, anisotropía en V, exciclotropía. Los pacientes con paresias y/o parálisis adquirida muestran diplopía vertical y torsional que aumenta con la mirada hacia abajo, tortícolis con inclinación de la cabeza hacia el lado opuesto del ojo afectado y descenso del mentón. El paciente acude a consulta por presentar diplopía vertical y torsional de 13 años de evolución. Al examen de la motilidad ocular había ortotropía en la Posición Primaria de la Mirada con hiperforia al cover test ojo izquierdo, 10 Dp base inferior por barra de prismas, exciclotropía 5*, tortícolis hacia la derecha y Bielschowsky positivo hacia el lado izquierdo. La impresión diagnóstica fue paresia adquirida del músculo OS izquierdo de etiología no precisada. El tratamiento realizado fue la retroinserción del recto superior del ojo izquierdo 4 mm más el desplazamiento temporal de un 1/4 de la inserción con el objetivo de eliminar la diplopía vertical y torsional y la posición anómala de la cabeza.
Quantitative analysis of textures produced in a hot-extruded zirconium plate; Analyse quantitative des textures developpees dans une plaque de zirconium filee a chaud

Energy Technology Data Exchange (ETDEWEB)

Couterne, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires. Institut national des sciences et techniques nucleaires, laboratoire de metallurgie

1967-01-01

ete etudiees par la methode de Schulz en se referant a un etalon isotrope. Ces textures ont. ete determinees soit parallelement au plan de la plaque, soit parallelement au plan des rives. Tous les resultats sont analyses dans une discussion finale qui permet, en particulier au voisinage des aretes de la plaque, de montrer que certaines composantes des textures observees clans les deux series d'enregistrements, sont en fait l'expression de la meme texture vue sous deux angles differents. D'autre part. it est montre que le zirconium ainsi mis en forme comporte des textures d'ecrouissage et de recristallisation posterieure a l'ecrouissage precedent. En schematisant l'ensemble des textures determinees, on observe trois textures dont deux deja signalees dans la bibliographie et comparable a celles des produits lamines: ces textures sont telles que les plans. (0001 presentent des inclinaisons respectives de 36 deg C et 60 deg C par rapport a un plan tangent a la courbe (enveloppe des vitesses d'ecoulement transverse) resulant de la geometrie du filage considere; la troisieme texture est definie par le fait que le plan (0001) est orthogonal aux surfaces exterieures de la plaque. La direction de filage associee a ces plans et commune aux trois textures est du type <1010>. Des essais dilatometriques ont ete effectues sur des echantillons preleves dans le sens du filage et clans le sens transverse. Ces essais mettent en evidence l'anisotropie dilatometrique du zirconium ainsi qu'un changement de pente de la courbe ({alpha}{sub v}){sub a} en fonction de la temperature a partir de 400 drg C, pouvant etre explique par la variation de la configuration electronique du metal a partir de cette temperature. (auteur)
Quantitative analysis of textures produced in a hot-extruded zirconium plate; Analyse quantitative des textures developpees dans une plaque de zirconium filee a chaud

Energy Technology Data Exchange (ETDEWEB)

Couterne, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires. Institut national des sciences et techniques nucleaires, laboratoire de metallurgie

1967-01-01

etudiees par la methode de Schulz en se referant a un etalon isotrope. Ces textures ont. ete determinees soit parallelement au plan de la plaque, soit parallelement au plan des rives. Tous les resultats sont analyses dans une discussion finale qui permet, en particulier au voisinage des aretes de la plaque, de montrer que certaines composantes des textures observees clans les deux series d'enregistrements, sont en fait l'expression de la meme texture vue sous deux angles differents. D'autre part. it est montre que le zirconium ainsi mis en forme comporte des textures d'ecrouissage et de recristallisation posterieure a l'ecrouissage precedent. En schematisant l'ensemble des textures determinees, on observe trois textures dont deux deja signalees dans la bibliographie et comparable a celles des produits lamines: ces textures sont telles que les plans. (0001 presentent des inclinaisons respectives de 36 deg C et 60 deg C par rapport a un plan tangent a la courbe (enveloppe des vitesses d'ecoulement transverse) resulant de la geometrie du filage considere; la troisieme texture est definie par le fait que le plan (0001) est orthogonal aux surfaces exterieures de la plaque. La direction de filage associee a ces plans et commune aux trois textures est du type <1010>. Des essais dilatometriques ont ete effectues sur des echantillons preleves dans le sens du filage et clans le sens transverse. Ces essais mettent en evidence l'anisotropie dilatometrique du zirconium ainsi qu'un changement de pente de la courbe ({alpha}{sub v}){sub a} en fonction de la temperature a partir de 400 drg C, pouvant etre explique par la variation de la configuration electronique du metal a partir de cette temperature. (auteur)
Effects of solar PAR and UV radiation on tropical biofouling communities

KAUST Repository

Dobretsov, SV; Gosselin, L; Qian, P

2010-01-01

We investigated the effect of solar ultraviolet radiation (UVR) and photosynthetically active radiation (PAR) on the development of tropical micro- and macrofouling communities for 30 d. The experimental design involved 3 treatments: full spectrum
Predicting spectral and PAR light attenuation in Greenlandic coastal waters

DEFF Research Database (Denmark)

Murray, Ciarán; Markager, Stiig; Stedmon, Colin

(CDOM), phytoplankton pigments and inorganic particles. These differences are due in part to hydrography and to the sources of meltwater: respectively, fjord-terminating and land-terminating glaciers. We present a model to explain the variation in spectral and PAR irradiance in terms of the variation...
Estuarine morphometry governs optically active substances, Kd(PAR) and beam attenuation

DEFF Research Database (Denmark)

Lund-Hansen, L. C.; Nielsen, J. M.; Blüthgen, J.

2013-01-01

estuaries using OACs as input parameters. It is concluded that there are no large differences in OAC concentrations between the two estuaries. The spatial distributions of OACs and optical properties were significantly different and governed by the estuary morphometry, i.e. a power distribution......°N) at high discharges. The major difference was the spatial distribution of the optical properties against distance, best described by significant power functions in the ria, compared to significant linear functions in the coastal plain. It was hypothesized that estuarine morphometry could explain...... this spatial distribution. Partition and multiple regression analyses showed that Chl-a governed Kd(PAR) and beam attenuation coefficient in both estuaries. Significant, high correlations were obtained by multiple regression analyses in the estimation of Kd(PAR) and beam attenuation coefficients in the two...
Youth empowerment in context: exploring tensions in school-based yPAR.

Science.gov (United States)

Kohfeldt, Danielle; Chhun, Lina; Grace, Sarah; Langhout, Regina Day

2011-03-01

In much of the youth empowerment literature, researchers focus on the relationship between youth and adults involved in empowerment programs while neglecting the broader social framework in which these relationships and the program itself functions. Utilizing an ecological model, the current research examines the tensions that surfaced in attempts to create an empowering setting in an after-school PAR program with fifth-graders. Challenging assumptions about youth, structural challenges, and conflicting theories of change are highlighted. Results examine the role of sociocultural context as PAR researchers attempt to create a setting in which students gain skills to become change agents within their school. The study suggests that youth empowerment is a context dependent process that requires attention to a multiplicity of factors that influence possibilities for empowerment via second order change.
Regulator of G protein signaling 2 (RGS2 and RGS4 form distinct G protein-dependent complexes with protease activated-receptor 1 (PAR1 in live cells.

Directory of Open Access Journals (Sweden)

Sungho Ghil

Full Text Available Protease-activated receptor 1 (PAR1 is a G-protein coupled receptor (GPCR that is activated by natural proteases to regulate many physiological actions. We previously reported that PAR1 couples to Gi, Gq and G12 to activate linked signaling pathways. Regulators of G protein signaling (RGS proteins serve as GTPase activating proteins to inhibit GPCR/G protein signaling. Some RGS proteins interact directly with certain GPCRs to modulate their signals, though cellular mechanisms dictating selective RGS/GPCR coupling are poorly understood. Here, using bioluminescence resonance energy transfer (BRET, we tested whether RGS2 and RGS4 bind to PAR1 in live COS-7 cells to regulate PAR1/Gα-mediated signaling. We report that PAR1 selectively interacts with either RGS2 or RGS4 in a G protein-dependent manner. Very little BRET activity is observed between PAR1-Venus (PAR1-Ven and either RGS2-Luciferase (RGS2-Luc or RGS4-Luc in the absence of Gα. However, in the presence of specific Gα subunits, BRET activity was markedly enhanced between PAR1-RGS2 by Gαq/11, and PAR1-RGS4 by Gαo, but not by other Gα subunits. Gαq/11-YFP/RGS2-Luc BRET activity is promoted by PAR1 and is markedly enhanced by agonist (TFLLR stimulation. However, PAR1-Ven/RGS-Luc BRET activity was blocked by a PAR1 mutant (R205A that eliminates PAR1-Gq/11 coupling. The purified intracellular third loop of PAR1 binds directly to purified His-RGS2 or His-RGS4. In cells, RGS2 and RGS4 inhibited PAR1/Gα-mediated calcium and MAPK/ERK signaling, respectively, but not RhoA signaling. Our findings indicate that RGS2 and RGS4 interact directly with PAR1 in Gα-dependent manner to modulate PAR1/Gα-mediated signaling, and highlight a cellular mechanism for selective GPCR/G protein/RGS coupling.
Contamination des eaux de puits traditionnels par les nitrates sur le ...

African Journals Online (AJOL)

SARAH

30 juin 2014 ... Objectif : La contamination des eaux souterraines par les nitrates est un ... Methodology and Results: the origin of nitrate water from traditional wells of Lobo's watershed was ...... 12 water supply wells, Yucatan, Mexico.
Densité, morphologie urbaine et qualité de vie. Une approche par le projet

OpenAIRE

Occhiuto, Rita; Goossens, Marc; Fisher, Axel

2013-01-01

La recherche "Densification des tissus urbanisés en Wallonie: forme, acceptabilité et modalités pour accompagner la mutation des tissus bâtis" s'articule en plusieurs volets thématiques, parmi lesquels figure le volet "formes urbaines, modes d'habitat". Ce dernier volet est abordé selon deux approches parallèles et complémentaires qui se valident mutuellement: la première dite "par le projet" (approche qualitative et opérationnelle) et la seconde par analyse statistique et cartographique (ap...
Flow cytometry analysis reveals different activation profiles of thrombin- or TRAP-stimulated platelets in db/db mice. The regulatory role of PAR-3.

Science.gov (United States)

Kassassir, Hassan; Siewiera, Karolina; Talar, Marcin; Przygodzki, Tomasz; Watala, Cezary

2017-06-01

Recent studies have shown that it may be the concentration of thrombin, which is discriminative in determining of the mechanism of platelet activation via protease activated receptors (PARs). Whether the observed phenomenon of differentiated responses of mouse platelets to various thrombin concentrations in non-diabetic db/+ and diabetic db/db mice depends upon the concerted action of various PARs, remains to be established. We found elevated reactivity of platelets, as well as the enhanced PAR-3 expression in response to both the used concentrations of AYPGKF in db/db mice, as compared to db/+ heterozygotes. At low concentration of thrombin platelets from diabetic mice demonstrated hyperreactivity, reflected by higher expression of PAR-3. For higher thrombin concentration, blood platelets from db/db mice appeared hyporeactive, compared to db/+ animals, while no significant differences in PAR-3 expression were observed between diabetic and non-diabetic mice. The novel and previously unreported finding resulting from our study is that the increased expression of PAR-3 in response to either TRAP for PAR-4 or low thrombin (when PAR-4 is not the efficient thrombin receptor) may be one of the key events contributing to higher reactivity of platelets in db/db mice. Copyright © 2017 Elsevier Inc. All rights reserved.

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