Clinical Investigation Program.

Science.gov (United States)

1987-09-30

Mexico , September 1987. Publications: None ! ~t 4, FAMC A.P.R. (RCS MED 300) Detail Summary Sheet (HSCR 40-23 as amended) (1) Date: 30 Sep 87 (2...Infection: A Prospective Study. Presented: 2nd Annual Symposium of the Rocky Moun-tain Flow Cytometry Users Group, Albuquerque, New Mexico , 10-11...COL, MC (9) Dept/Sv:Pe-at (10) Associate Tnvestigators (lI) Tey WoJr--s: Myron J. Levin, M.D. varicella vaccine U Co. HSC (12) Accumu tEve MEDCASE:* 1

Bokföringslagens förändringar år 2016 : Med fokus på småföretag

OpenAIRE

Häggblom, Caroline

2017-01-01

Från och med år 2016 ändrades bokföringslagen i Finland. Detta på grund av ett direktiv som Europaparlamentet tillsammans med rådet kom ut med år 2013. I och med denna ändring påverkas alla företag som är bokföringsskyldiga i något skede, vilket innebär att det är ett aktuellt och viktigt ämne att studera. I detta arbete förklaras grunderna i bokföring, vad bokföringslagen innehåller samt ändringarna som skett i lagen och konsekvenserna av dem. Informationen till förändringarna i bokföring...

Græsensilage med forskellig snitlængde til drægtige og diegivende moderfår

DEFF Research Database (Denmark)

Eilersen, Rie Jasmund; Arnesson, Annika; Nadeau, Elisabet

2009-01-01

Forsøget viste, at får med tvilling lam der gives 0,8 kg kraftfoder pr dag, under diegivningen æder 1,5 gange mere ensilage end under drægtigheden. Snitning af ensilagen til en partikellængde på 1,3 cm medførte ikke højere optagelse af ensilage ved separat fodring. Når ensilage med denne snitlængde...... indgik i fuldfoder havde fårene en 12% større daglig foderoptagelse efter læmning sammenlignet med separat fodertildeling....

Dam methylation participates in the regulation of PmrA/PmrB and RcsC/RcsD/RcsB two component regulatory systems in Salmonella enterica serovar Enteritidis.

Directory of Open Access Journals (Sweden)

Sebastián Hernán Sarnacki

Full Text Available The absence of Dam in Salmonella enterica serovar Enteritidis causes a defect in lipopolysaccharide (LPS pattern associated to a reduced expression of wzz gene. Wzz is the chain length regulator of the LPS O-antigen. Here we investigated whether Dam regulates wzz gene expression through its two known regulators, PmrA and RcsB. Thus, the expression of rcsB and pmrA was monitored by quantitative real-time RT-PCR and Western blotting using fusions with 3×FLAG tag in wild type (wt and dam strains of S. Enteritidis. Dam regulated the expression of both rcsB and pmrA genes; nevertheless, the defect in LPS pattern was only related to a diminished expression of RcsB. Interestingly, regulation of wzz in serovar Enteritidis differed from that reported earlier for serovar Typhimurium; RcsB induces wzz expression in both serovars, whereas PmrA induces wzz in S. Typhimurium but represses it in serovar Enteritidis. Moreover, we found that in S. Enteritidis there is an interaction between both wzz regulators: RcsB stimulates the expression of pmrA and PmrA represses the expression of rcsB. Our results would be an example of differential regulation of orthologous genes expression, providing differences in phenotypic traits between closely related bacterial serovars.

75 FR 28480 - Airworthiness Directives; Airbus Model A300 Series Airplanes; Model A300 B4-600, B4-600R, F4-600R...

Science.gov (United States)

2010-05-21

... Airworthiness Directives; Airbus Model A300 Series Airplanes; Model A300 B4-600, B4-600R, F4-600R Series..., B4-622, B4- 605R, B4-622R, F4-605R, F4-622R, and C4-605R Variant F airplanes; and Model A310-203...

Forord til den danske udgave af bogen rådgivning og terapi med børn

DEFF Research Database (Denmark)

Kragh-Müller, Grethe

2007-01-01

En bog om rådgivning og terapi med børn med en integrativ indfaldsvinkel. Der tages udgangspunkt i forskellige teorier og metoder.......En bog om rådgivning og terapi med børn med en integrativ indfaldsvinkel. Der tages udgangspunkt i forskellige teorier og metoder....

Clinical Investigation Program Annual Progress Report

Science.gov (United States)

1988-10-20

Presented: Interna- tional Symposium on Orthopedics, Mexico , September 1987. Publications: In preparation. 147 FAMC A.P.R. (RCS MED 300) Detail Summary...Infection: A Prospective Study. Presented: 2nd Annual Symposium of the Rocky Moun- tain Flow Cytometry Users Group, Albuquerque, New Mexico , 10-11...Podgore, COL, MC (9) Dept/ISvc: Pediatrics (10) Associate Investigators (11) Key Words: Myron J. Levin, M.D. varicella vaccine U Co. HSC (12

rDNA insulin glargine U300 – a critical appraisal

Directory of Open Access Journals (Sweden)

Wang F

2016-12-01

Full Text Available Fei Wang,1 Stefanie Zassman,1 Philip A Goldberg2 1Department of Pharmacy Practice, School of Pharmacy, University of Connecticut, Storrs, CT, USA; 2Department of Internal Medicine, Section of Endocrinology, Yale University School of Medicine, New Haven, CT, USA Background: As the first once-daily basal insulin analog, insulin glargine 100 U/mL (Gla‑100; Lantus® rapidly evolved into the most commonly prescribed insulin therapy worldwide. However, this insulin has clinical limitations. The approval of new basal insulin analogs in 2015 has already started to alter the prescribing landscape.Objective: To review the available evidence on the clinical efficacy and safety of a more concentrated insulin glargine (recombinant DNA origin injection 300 U/mL (Gla-300 compared to insulin Gla-100 in patients with type 1 and type 2 diabetes mellitus (T1DM and T2DM.Methods: The following electronic databases were searched: PubMed and MEDLINE (using Ovid platform, Scopus, BIOSIS, and Google Scholar through June 2016. Conference proceedings of the American Diabetes Association (2015–2016 were reviewed. We also manually searched reference lists of pertinent reviews and trials.Results: A total of 6 pivotal Phase III randomized controlled trials known as the EDITION series were reviewed. All of these trials (n=3,500 were head-to-head comparisons evaluating the efficacy and tolerability of Gla-300 vs Gla-100 in a diverse population with T1DM and T2DM. These trials were of 6 months duration with a 6-month safety extension phase.Conclusion: Gla-300 was as effective as Gla-100 for improving glycemic control over 6 months in all studies, with a lower risk of nocturnal hypoglycemia significant only in insulin-experienced patients with T2DM. Overall, patients on Gla-300 required 10%–18% more basal insulin, but with less weight gain compared with Gla-100. Keywords: basal insulin, glargine 300 U/mL, glargine 100 U/mL

Endothelin-1 promotes epithelial–mesenchymal transition in human chondrosarcoma cells by repressing miR-300

Science.gov (United States)

Wu, Min-Huan; Huang, Pei-Han; Hsieh, Mingli; Tsai, Chun-Hao; Chen, Hsien-Te; Tang, Chih-Hsin

2016-01-01

Chondrosarcoma is a malignant tumor of mesenchymal origin predominantly composed of cartilage-producing cells. This type of bone cancer is extremely resistant to radiotherapy and chemotherapy. Surgical resection is the primary treatment, but is often difficult and not always practical for metastatic disease, so more effective treatments are needed. In particular, it would be helpful to identify molecular markers as targets for therapeutic intervention. Endothelin-1 (ET-1), a potent vasoconstrictor, has been shown to enhance chondrosarcoma angiogenesis and metastasis. We report that ET-1 promotes epithelial–mesenchymal transition (EMT) in human chondrosarcoma cells. EMT is a key pathological event in cancer progression, during which epithelial cells lose their junctions and apical-basal polarity and adopt an invasive phenotype. Our study verifies that ET-1 induces the EMT phenotype in chondrosarcoma cells via the AMP-activated protein kinase (AMPK) pathway. In addition, we show that ET-1 increases EMT by repressing miR-300, which plays an important role in EMT-enhanced tumor metastasis. We also show that miR-300 directly targets Twist, which in turn results in a negative regulation of EMT. We found a highly positive correlation between ET-1 and Twist expression levels as well as tumor stage in chondrosarcoma patient specimens. Therefore, ET-1 may represent a potential novel molecular therapeutic target in chondrosarcoma metastasis. PMID:27602960

Endothelin-1 promotes epithelial-mesenchymal transition in human chondrosarcoma cells by repressing miR-300.

Science.gov (United States)

Wu, Min-Huan; Huang, Pei-Han; Hsieh, Mingli; Tsai, Chun-Hao; Chen, Hsien-Te; Tang, Chih-Hsin

2016-10-25

Chondrosarcoma is a malignant tumor of mesenchymal origin predominantly composed of cartilage-producing cells. This type of bone cancer is extremely resistant to radiotherapy and chemotherapy. Surgical resection is the primary treatment, but is often difficult and not always practical for metastatic disease, so more effective treatments are needed. In particular, it would be helpful to identify molecular markers as targets for therapeutic intervention. Endothelin-1 (ET-1), a potent vasoconstrictor, has been shown to enhance chondrosarcoma angiogenesis and metastasis. We report that ET-1 promotes epithelial-mesenchymal transition (EMT) in human chondrosarcoma cells. EMT is a key pathological event in cancer progression, during which epithelial cells lose their junctions and apical-basal polarity and adopt an invasive phenotype. Our study verifies that ET-1 induces the EMT phenotype in chondrosarcoma cells via the AMP-activated protein kinase (AMPK) pathway. In addition, we show that ET-1 increases EMT by repressing miR-300, which plays an important role in EMT-enhanced tumor metastasis. We also show that miR-300 directly targets Twist, which in turn results in a negative regulation of EMT. We found a highly positive correlation between ET-1 and Twist expression levels as well as tumor stage in chondrosarcoma patient specimens. Therefore, ET-1 may represent a potential novel molecular therapeutic target in chondrosarcoma metastasis.

Obamas opgør med Bush låser ham i dronekrig

DEFF Research Database (Denmark)

Ulrich, Philip Christian

2013-01-01

En helt central del af Obamas valgkamp i 2008 var et opgør med dele af Bush administrationens krig mod terror. Obama er dog blevet fanget i en kontroversiel dronepolitik på grund af hans manglende succes med de indenrigspolitiske aspekter af opgøret...

Bør det være strafbart at have sex med dyr?

DEFF Research Database (Denmark)

Christiansen, Stine Billeschou; Greve, Vagn; Sandøe, Peter

2009-01-01

Artiklen opridser baggrunden for den standende diskussion om, hvorvidt der i Danmark bør være et generelt og absolut forbud mod menneskers seksuelle omgang med dyr. Indledningsvis gives et historisk overblik over udviklingen i den danske regulering af menneskers seksuelle omgang med dyr. Efterføl...

Inferior ectopic pupil and typical ocular coloboma in RCS rats.

Science.gov (United States)

Tsuji, Naho; Ozaki, Kiyokazu; Narama, Isao; Matsuura, Tetsuro

2011-08-01

Ocular coloboma is sometimes accompanied by corectopia in humans and therefore ectopic pupil may indicate ocular coloboma in experimental animals. The RCS strain of rats has a low incidence of microphthalmia. We found that inferior ectopic pupil is associated exclusively with small-sized eyes in this strain. The objective of the current study was to evaluate whether inferior ectopic pupil is associated with iridal coloboma and other types of ocular coloboma in RCS rats. Both eyes of RCS rats were examined clinically, and those with inferior ectopic pupils underwent morphologic and morphometric examinations. In a prenatal study, coronal serial sections of eyeballs from fetuses at gestational day 16.5 were examined by using light microscopy. Ectopic pupils in RCS rats were found exclusively in an inferior position, where the iris was shortened. Fundic examination revealed severe chorioretinal coloboma in all cases of inferior ectopic pupil. The morphologic characteristics closely resembled those of chorioretinal coloboma in humans. Histopathologic examination of primordia showed incomplete closure of the optic fissure in 4 eyeballs of RCS fetuses. Neither F(1) rats nor N(2) (progeny of RCS × BN matings) displayed any ocular anomalies, including ectopic pupils. The RCS strain is a suitable model for human ocular coloboma, and inferior ectopic pupil appears to be a strong indicator of ocular coloboma.

On-Orbit Propulsion OMS/RCS

Science.gov (United States)

Hurlbert, Eric A.

2001-01-01

This slide presentation reviews the Space Shuttle's On-Orbit Propulsion systems: the Orbital Maneuvering System (OMS) and the Reaction Control System (RCS). The functions of each of the systems is described, and the diagrams of the systems are presented. The OMS/RCS thruster is detailed and a trade study comparison of non-toxic propellants is presented.

Systemic administration of erythropoietin inhibits retinopathy in RCS rats.

Directory of Open Access Journals (Sweden)

Weiyong Shen

Full Text Available OBJECTIVE: Royal College of Surgeons (RCS rats develop vasculopathy as photoreceptors degenerate. The aim of this study was to examine the effect of erythropoietin (EPO on retinopathy in RCS rats. METHODS: Fluorescein angiography was used to monitor retinal vascular changes over time. Changes in retinal glia and vasculature were studied by immunostaining. To study the effects of EPO on retinal pathology, EPO (5000 IU/kg was injected intraperitoneally in 14 week old normal and RCS rats twice a week for 4 weeks. Changes in the retinal vasculature, glia and microglia, photoreceptor apoptosis, differential expression of p75 neurotrophin receptor (p75NTR, pro-neurotrophin 3 (pro-NT3, tumour necrosis factor-α (TNFα, pigment epithelium derived factor (PEDF and vascular endothelial growth factor-A (VEGF-A, the production of CD34(+ cells and mobilization of CD34(+/VEGF-R2(+ cells as well as recruitment of CD34(+ cells into the retina were examined after EPO treatment. RESULTS: RCS rats developed progressive capillary dropout and subretinal neovascularization which were accompanied by retinal gliosis. Systemic administration of EPO stabilized the retinal vasculature and inhibited the development of focal vascular lesions. Further studies showed that EPO modulated retinal gliosis, attenuated photoreceptor apoptosis and p75NTR and pro-NT3 upregulation, promoted the infiltration of ramified microglia and stimulated VEGF-A expression but had little effect on TNFα and PEDF expression. EPO stimulated the production of red and white blood cells and CD34(+ cells along with effective mobilization of CD34(+/VEGF-R2(+ cells. Immunofluorescence study demonstrated that EPO enhanced the recruitment of CD34+ cells into the retina. CONCLUSIONS: Our results suggest that EPO has therapeutic potentials in treatment of neuronal and vascular pathology in retinal disease. The protective effects of EPO on photoreceptors and the retinal vasculature may involve multiple

Lærernes vilkår gør det svært at lykkes med inklusion og differentieret undervisning

DEFF Research Database (Denmark)

Hedegaard-Sørensen, Lotte; Grumløse, Sine Penthin

2017-01-01

Debatindlæg i Skoleliv Politiken om sammenhængen mellem læreres vilkår for at arbejde inkluderende med særligt fokus på organisatoriske betingelser for samarbejde og fælles forberedelse med andre faggrupper....

Evaluering af ordning med psykologbehandling af personer med let til moderat depression

DEFF Research Database (Denmark)

Fjeldsted, Rita; Christensen, Kaj Sparle

Herværende rapport evaluerer den pr. 1.4.2008 indførte ordning med mulighed for henvisning til psykologbehandling med 60 % tilskud for patienter med let til moderat depression. Evalueringen har betjent sig af flere gensidigt supplerende metoder: spørgeskemaundersøgelser overfor patienter, psykolo......Herværende rapport evaluerer den pr. 1.4.2008 indførte ordning med mulighed for henvisning til psykologbehandling med 60 % tilskud for patienter med let til moderat depression. Evalueringen har betjent sig af flere gensidigt supplerende metoder: spørgeskemaundersøgelser overfor patienter...... tidligere evaluering af forsøgsordning af psykologbehandling af depression i perioden 2005-06. 18.419 personer i alderen 18-37 år blev henvist til psykolog i den undersøgte ordning i perioden 1.2.2009 – 31.1.2010, svarende til en henvisningshyppighed på 1,6 % af baggrundsbefolkningen i samme aldersgruppe....... Ordningen giver mulighed for én rehenvisning, og 9 % blev rehenvist i perioden. Spørgeskemaresultater viser, at kun 33 % af de henviste falder ind under henvisningskriteriet ” let til moderat depression” på tidspunktet for opstart af psykologbehandling, 39 % har ingen tegn på depression, og 28 % har svær...

Tillverkningsmetod för tillverkning av däcksluckor med glas

OpenAIRE

Gripenberg, Lars

2010-01-01

Arbetet går ut på att hitta ett system för att tillverka däcksluckor med glas internt på Nautor. Detta är idag en produkt som vi köper utifrån av en extern leverantör till höga priser därför att vi inte själva har ett fungerande koncept för dylika produkter. Arbetet består av att kartlägga vilka olika tillverkningsmetoder som finns som är lämpade för detta ändamål, (Handlaminat, Injecering, Prepreg, mm). En eller två tillverkningsmetoder väljs ut och därefter tillverkas ett provexemp...

Metasurface base on uneven layered fractal elements for ultra-wideband RCS reduction

Science.gov (United States)

Su, Jianxun; Cui, Yueyang; Li, Zengrui; Yang, Yaoqing Lamar; Che, Yongxing; Yin, Hongcheng

2018-03-01

A novel metasurface based on uneven layered fractal elements is designed and fabricated for ultra-wideband radar cross section (RCS) reduction in this paper. The proposed metasurface consists of two fractal subwavelength elements with different layer thickness. The reflection phase difference of 180° (±37°) between two unit cells covers an ultra-wide frequency range. Ultra-wideband RCS reduction results from the phase cancellation between two local waves produced by these two unit cells. The diffuse scattering of electromagnetic (EM) waves is caused by the randomized phase distribution, leading to a low monostatic and bistatic RCS simultaneously. This metasurface can achieve -10dB RCS reduction in an ultra-wide frequency range from 6.6 to 23.9 GHz with a ratio bandwidth (fH/fL) of 3.62:1 under normal incidences for both x- and y-polarized waves. Both the simulation and the measurement results are consistent to verify this excellent RCS reduction performance of the proposed metasurface.

76 FR 42029 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Science.gov (United States)

2011-07-18

... Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and Model A300 C4... A300 B4-605R and B4-622R airplanes, Model A300 F4-605R and F4-622R airplanes, and Model A300 C4- [[Page...

75 FR 60611 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Science.gov (United States)

2010-10-01

... Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and Model A300 C4...; Model A300 B4-601, B4- 603, B4-620, B4-622, B4-605R, B4-622R, F4-605R, F4-622R, and C4-605R Variant F...-- Dated-- A300 series airplanes......... A300-32A0447..... April 22, 2004. A300 B4-600, B4-600R, and F4...

Gemensam modell för professionella : E-klubb för närståendevårdare till personer med Multipel Skleros

OpenAIRE

Ekholm, Johanna; Lukkari, Noora; Nordberg, Marie; Parviainen, Jolanda

2017-01-01

Detta examensarbete är en del av ett projekt som Yrkeshögskolan Novia inledde redan våren 2016. Syftet med arbetet är främja hälsa och välbefinnande samt stöda och stärka närståendevårdarens egna resurser. Målet med arbetet är att skapa en gemensam modell för en e-klubb som skall användas av professionella. Grunden för arbetet har varit tjänstedesign och litteraturöversikt. Arbetet är uppdelat i två delar: en gemensam modell för uppbyggandet av en e klubb samt en målgruppsspecifik del. Den...

75 FR 76926 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Science.gov (United States)

2010-12-10

... Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R... airplanes; Model A300 B4-605R and B4-622R airplanes; Model A300 F4-605R and F4-622R airplanes; Model A300 C4...

Analysis of effect of late water injection on RCS repressurization

International Nuclear Information System (INIS)

Tao Jun; Cao Xuewu

2011-01-01

Effect of late water injection on RCS repressurization during high pressure severe accident sequence in a typical PWR was analyzed. As the results shown, late water injection could increase RCS pressure when RPV failed without RCS passive depressurization. Especially in the condition of opening one PORV, RCS pressure could reach high pressure limit when RPV failed and the risk of HPME and DCH was dramatically increased. Integrity of containment could be threatened. However, in the condition of RCS passive depressurization induced by pressurizer surge line creep failure, RCS pressure could be decreased to very low level even only one PORV was opened and two trains of emergency core cooling were implemented. The risk of HPME and DCH was eliminated. The more PORVs were opened, the faster accident progression was and the earlier RPV failed. RCS pressure was a little higher when PRV failed if two trains of emergency core cooling was implemented comparing with the condition with only one train of emergency core cooling. However the time of RPV failure was obviously delayed. From the point of delaying RPV failure and preventing containment early failure of view, the optimized late water injection was opening three PORVs and implementing two trains of emergency core cooling. (authors)

Arbetsmöbel för ungdomar : Beskrivning av designprocessen i ett samarbete med IKEA

OpenAIRE

Leckström, Anna

2007-01-01

Rapporten beskriver ett designprojekt, utfört som en del av examensarbetet på 15 HP, jag utfört som avgångsstudent på möbeldesignprogrammet vid Carl Malmsten Centrum för Träteknik & Design. Från Ronnie Runesson, produktutvecklare på IKEA of Sweden, fick jag ett uppdrag, ett reellt projekt att arbeta med. Projektet handlade om att ta fram ett koncept på en ny typ av arbetsmöbel för ungdomar i åldersgruppen 12 – 18 år. Målet med projektet var att, förutom att leverera ett fungerande koncept...

Cone function studied with flicker electroretinogram during progressive retinal degeneration in RCS rats.

Science.gov (United States)

Pinilla, I; Lund, R D; Sauvé, Y

2005-01-01

The Royal College of Surgeons (RCS) rat has a primary defect in retinal pigment epithelial cells that leads to the progressive loss of photoreceptors and central visual responsiveness. While most rods are lost by 90 days of age (P90), cones degenerate more slowly, and can be detected anatomically up to 2 years of age, despite massive neuronal death and retinal remodelling. To examine how this progressive degenerative process impacts on cone function, we recorded the electroretingram to white light flashes (1.37 log cd s m(-2)) presented at frequencies ranging from 3 to 50 Hz, under light adapted conditions (29.8 cd m(-2)). Pigmented dystrophic and congenic non-dystrophic RCS rats aged from 18 to 300 days were studied. In all responsive animals at all ages, maximal amplitudes were obtained at 3 Hz. In both non-dystrophic and dystrophic rats, there was an increase from P18 to P21 in response amplitude and critical fusion frequency. After P21, these two parameters declined progressively with age in dystrophic rats. Other changes included prolongation in latency, which was first detected prior to the initiation of amplitude reduction. While phase shifts were also detected in dystrophic RCS rats, they appeared at later degenerative stages. The latest age at which responses could be elicited in dystrophic rats was at P200, with positive waves being replaced by negative deflections. The effect of increments in the intensity of background illumination was tested at P50 in both groups. This caused a diminution in flicker response amplitude and critical fusion frequencies in non-dystrophics, while in dystrophic animals, response amplitudes were reduced only at low frequencies and critical fusion frequencies were unaltered. In conclusion, although dystrophic RCS rats undergo a progressive decline in cone function with age, the flicker responsiveness at P21 is comparable to that of non-dystrophic congenic rats, suggesting normal developmental maturation of the cone system in

Accumulation of neurocan, a brain chondroitin sulfate proteoglycan, in association with the retinal vasculature in RCS rats.

Science.gov (United States)

Zhang, Yiqin; Rauch, Uwe; Perez, Maria-Thereza R

2003-03-01

To examine whether and how the retinal distribution of the chondroitin sulfate proteoglycan neurocan is affected after photoreceptor cell loss and whether it correlates with the multiple secondary cellular changes that accompany the photoreceptor degeneration. Retinas from normal rats (Sprague-Dawley; postnatal days [P]0-P70), RCS rats with dystrophic retinas (P0-P300), RCS-rdy(+) congenic rats with nondystrophic retinas (P0-202), and rhodopsin mutant rats, P23H (P0-P257) and S334ter (P0-P220), were processed for immunohistochemistry using a polyclonal antibody to rat neurocan. The overall distribution of neurocan was similar in all retinas examined. Neurocan immunostaining was detected over the nerve fiber layer, the plexiform layers, the photoreceptor outer segments region, and the ciliary epithelium. With age, labeling throughout the plexiform layers decreased continuously. In RCS rats however, conspicuous labeling was also seen in association with retinal vessels, from P15 onward. Accumulation of neurocan in association with the retinal vasculature does not correlate with photoreceptor cell loss, because it was not observed in the rhodopsin mutant rats. During the earliest stages of the disease, accumulation of debris in the subretinal space in RCS rats may be sufficient per se to initiate a cascade of metabolic changes that result in accumulation of neurocan. With time, the neurocan accumulated perivascularly may, by interaction with other matrix molecules, modulate at least some of the vascular alterations observed in this animal model.

Spectroscopic characterization of galaxy clusters in RCS-1: spectroscopic confirmation, redshift accuracy, and dynamical mass-richness relation

Science.gov (United States)

Gilbank, David G.; Barrientos, L. Felipe; Ellingson, Erica; Blindert, Kris; Yee, H. K. C.; Anguita, T.; Gladders, M. D.; Hall, P. B.; Hertling, G.; Infante, L.; Yan, R.; Carrasco, M.; Garcia-Vergara, Cristina; Dawson, K. S.; Lidman, C.; Morokuma, T.

2018-05-01

We present follow-up spectroscopic observations of galaxy clusters from the first Red-sequence Cluster Survey (RCS-1). This work focuses on two samples, a lower redshift sample of ˜30 clusters ranging in redshift from z ˜ 0.2-0.6 observed with multiobject spectroscopy (MOS) on 4-6.5-m class telescopes and a z ˜ 1 sample of ˜10 clusters 8-m class telescope observations. We examine the detection efficiency and redshift accuracy of the now widely used red-sequence technique for selecting clusters via overdensities of red-sequence galaxies. Using both these data and extended samples including previously published RCS-1 spectroscopy and spectroscopic redshifts from SDSS, we find that the red-sequence redshift using simple two-filter cluster photometric redshifts is accurate to σz ≈ 0.035(1 + z) in RCS-1. This accuracy can potentially be improved with better survey photometric calibration. For the lower redshift sample, ˜5 per cent of clusters show some (minor) contamination from secondary systems with the same red-sequence intruding into the measurement aperture of the original cluster. At z ˜ 1, the rate rises to ˜20 per cent. Approximately ten per cent of projections are expected to be serious, where the two components contribute significant numbers of their red-sequence galaxies to another cluster. Finally, we present a preliminary study of the mass-richness calibration using velocity dispersions to probe the dynamical masses of the clusters. We find a relation broadly consistent with that seen in the local universe from the WINGS sample at z ˜ 0.05.

76 FR 39248 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Science.gov (United States)

2011-07-06

... Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R... B4-605R and B4-622R airplanes; Model A300 F4-605R and F4-622R airplanes; Model A300 C4-605R Variant F...

Transient protective effect of caspase inhibitors in RCS rat.

Science.gov (United States)

Perche, O; Doly, M; Ranchon-Cole, I

2008-03-01

In most retinal degenerations in humans and in animal models, photoreceptor cells die by apoptosis. Although the biochemical features are similar in all apoptotic cells, different molecular events lead the cell to death. In the present study we used a rat model of inherited retinal degeneration, the RCS rats, to investigate the involvement of the proteases, caspases and/or calpains, in photoreceptor apoptosis. In the first experiments, rats were untreated or injected intravitreally at post natal day 27 (P27) with the large broad spectrum caspase inhibitor, ZVAD, the calpain inhibitor, MuhPhe, or with the vehicle, DMSO. Retinal status was evaluated at P35 and P42 by electroretinography, morphometry and apoptotic nuclei detection. DMSO and MuhPhe had no effect on RCS retinas as evidenced by equivalent loss of function and equivalent number of apoptotic cells than in untreated group. ZVAD transiently reduced apoptotic cells and preserved photoreceptor function at P35 but not at P42. These results suggest that caspases but not calpains are involved in retinal degeneration in the RCS. In the second experiments, RCS rats were injected twice at P27 and P35 with ZVAD or DMSO. Although ZVAD-treated retinas were preserved at P35 compared to the DMSO controls, the second injection of ZVAD did not extend the preserving effect to P42. Moreover, a single injection of ZVAD at P35 had no preserving effect at P42. All these data taken together suggest that caspases do not play a pivotal role after P35. In a fourth set of experiments, we used specific caspase inhibitors to elucidate which caspase was activated. The caspase-1/4 inhibitor (YVAD) or the caspase-3/7 inhibitor (DEVD) were injected intravitreally at P27 and retinal status was evaluated at P35 and P42. Electroretinograms and apoptotic nuclei detection demonstrated that YVAD and DEVD preserved photoreceptors at P35 but not at P42. These results suggest that both caspase-1/4 and caspase-3/7 play a major role in the apoptotic

Structural Basis for DNA Recognition by the Two-Component Response Regulator RcsB.

Science.gov (United States)

Filippova, Ekaterina V; Zemaitaitis, Bozena; Aung, Theint; Wolfe, Alan J; Anderson, Wayne F

2018-02-27

RcsB is a highly conserved transcription regulator of the Rcs phosphorelay system, a complex two-component signal transduction system (N. Majdalani and S. Gottesman, Annu Rev Microbiol 59:379-405, 2005; A. J. Wolfe, Curr Opin Microbiol 13:204-209, 2010, https://doi.org/10.1016/j.mib.2010.01.002; D. J. Clarke, Future Microbiol 5:1173-1184, 2010, https://doi.org/10.2217/fmb.10.83). RcsB plays an important role in virulence and pathogenicity in human hosts by regulating biofilm formation. RcsB can regulate transcription alone or together with its auxiliary transcription regulators by forming heterodimers. This complexity allows RcsB to regulate transcription of more than 600 bacterial genes in response to different stresses (D. Wang et al., Mol Plant Microbe Interact 25:6-17, 2012, https://doi.org/10.1094/MPMI-08-11-0207). Despite increasing knowledge of RcsB importance, molecular mechanisms that drive the ability of RcsB to control transcription of a large number of genes remain unclear. Here, we present crystal structures of unphosphorylated RcsB in complex with the consensus DNA-binding sequence of 22-mer (DNA22) and 18-mer (DNA18) of the flhDC operon from Escherichia coli determined at 3.15- and 3.37-Å resolution, respectively. The results of our structural analysis combined with the results of in vitro binding assays provide valuable insights to the protein regulatory mechanism, demonstrate how RcsB recognizes target DNA sequences, and reveal a unique oligomeric state that allows RcsB to form homo- and heterodimers. This information will help us understand the complex mechanisms of transcriptional regulation by RcsB in bacteria. IMPORTANCE RcsB is a well-studied two-component response regulator of the Rcs phosphorelay system, conserved within the family Enterobacteriaceae , which includes many pathogens. It is a global regulator, controlling more than 5% of bacterial genes associated with capsule biosynthesis, flagellar biogenesis, cell wall biosynthesis

Omvårdnadsåtgärder för att minska rädsla, oro och ångest hos barn 0-18 år i samband med en röntgenundersökning : En litteraturstudie

OpenAIRE

Mohsen, Nadja; Imsirovic, Amela

2016-01-01

Bakgrund: Att besöka en röntgenavdelning kan vara något nytt och skrämmande för många barn. Den nya miljön kan orsaka rädsla, oro och ångest hos barn. Därför är det viktigt att röntgensjuksköterskan har kunskap om barnets behov för att upplevelsen på röntgenavdelningen ska vara så bra som möjligt. Syfte: Syftet med den här studien är att beskriva omvårdnadsåtgärder för att minska rädsla, oro och ångest hos barn 0-18 år i samband med röntgenundersökning. Metod: Detta arbete är en litteraturstu...

Thermographic Inspections And The Residential Conservation Service Program (RCS)

Science.gov (United States)

Ward, Ronald J.

1983-03-01

Rhode Islanders Saving Energy (RISE) is a non-profit corporation founded in 1977 to provide Rhode Island residents with a variety of energy conservation services. Since January of 1981, it has been performing energy audits in compliance with the Department of Energy's (DOE) Residential Conservation Service Program (RCS). One aspect of the RCS program is the performance of inspections on energy conservation activities completed according to RCS installation guidelines. This paper will describe both the use and results of thermographic inspections within the RISE program. The primary objective of these inspections has been to assure the quality of the building envelope after completion of retrofit measures. Thermal anamolies have been detected that vary in size, location and probable cause. Approximately 37% of all jobs performed through RISE in conjunction with the RCS program have required remedial work as a result of problems that were identi-fied during the thermographic inspection. This percentage was much higher when infra-red inspections were conducted on "Non-RCS" retrofits. Statistics will be presented that provide an interesting insight on the quality of retrofit work when performed in associa-tion with a constant inspection process.

RCS Diversity of Electromagnetic Wave Carrying Orbital Angular Momentum.

Science.gov (United States)

Zhang, Chao; Chen, Dong; Jiang, Xuefeng

2017-11-13

An electromagnetic (EM) wave with orbital angular momentum (OAM) has a helical wave front, which is different from that of the plane wave. The phase gradient can be found perpendicular to the direction of propagation and proportional to the number of OAM modes. Herein, we study the backscattering property of the EM wave with different OAM modes, i.e., the radar cross section (RCS) of the target is measured and evaluated with different OAM waves. As indicated by the experimental results, different OAM waves have the same RCS fluctuation for the simple target, e.g., a small metal ball as the target. However, for complicated targets, e.g., two transverse-deployed small metal balls, different RCSs can be identified from the same incident angle. This valuable fact helps to obtain RCS diversity, e.g., equal gain or selective combining of different OAM wave scattering. The majority of the targets are complicated targets or expanded targets; the RCS diversity can be utilized to detect a weak target traditionally measured by the plane wave, which is very helpful for anti-stealth radar to detect the traditional stealth target by increasing the RCS with OAM waves.

A Novel Low RCS Design Method for X-Band Vivaldi Antenna

Directory of Open Access Journals (Sweden)

XiaoXiang He

2012-01-01

Full Text Available A novel low radar cross-section (RCS design method is proposed, and its application on Vivaldi antenna that covers the entire X band is investigated. According to the difference of the current distribution on the radiator when the antenna radiates or scatters, the shape of the metal radiator is modified, so that maximally 19.2 dBsm RCS reduction is achieved which satisfied radiation performance. Simulated and measured results about gain, S11, and RCS are presented. As a result, the effectiveness of the presented low RCS design method is validated.

Konceptutveckling av ett nytt utomhusgym med träningsredskap för offentlig utemiljö

OpenAIRE

Persson, Madeleine; Hammargren, Ellen

2013-01-01

I dagsläget är en stillasittande livsstil med inget eller endast litet inslag av fysisk aktivitet vanligt förekommande. Med sin slogan – Inspiring all generations – vill HAGS Aneby AB bjuda in alla generationer till fysisk aktivitet genom sina produkter inom lek, sport och fitness. Genom att styrka idén om utomhusgym kan den fysiska aktiviteten ökas – användare ska vilja använda utomhusgym och kunder ska vilja köpa in utomhusgym. Önskemålet är att skapa attraktiva platser som stödjer fysisk a...

Conformational dynamism for DNA interaction in the Salmonella RcsB response regulator.

Science.gov (United States)

Casino, Patricia; Miguel-Romero, Laura; Huesa, Juanjo; García, Pablo; García-Del Portillo, Francisco; Marina, Alberto

2018-01-09

The RcsCDB phosphorelay system controls an extremely large regulon in Enterobacteriaceae that involves processes such as biofilm formation, flagella production, synthesis of extracellular capsules and cell division. Therefore, fine-tuning of this system is essential for virulence in pathogenic microorganisms of this group. The final master effector of the RcsCDB system is the response regulator (RR) RcsB, which activates or represses multiple genes by binding to different promoter regions. This regulatory activity of RcsB can be done alone or in combination with additional transcriptional factors in phosphorylated or dephosphorylated states. The capacity of RcsB to interact with multiple promoters and partners, either dephosphorylated or phosphorylated, suggests an extremely conformational dynamism for this RR. To shed light on the activation mechanism of RcsB and its implication on promoter recognition, we solved the crystal structure of full-length RcsB from Salmonella enterica serovar Typhimurium in the presence and absence of a phosphomimetic molecule BeF3-. These two novel structures have guided an extensive site-directed mutagenesis study at the structural and functional level that confirms RcsB conformational plasticity and dynamism. Our data allowed us to propose a β5-T switch mechanism where phosphorylation is coupled to alternative DNA binding ways and which highlights the conformational dynamism of RcsB to be so pleiotropic. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

BYOD och Cloud Computing : En vägledande studie för hur BYOD bör bedrivas säkert tillsammans med cloud computing

OpenAIRE

Abramian, Fredrik; Wedholm, Joel

2013-01-01

Syftet med denna uppsats är att få en insikt i hur informationssäkerhetsarbetet påverkas av Bring Your Own Device (BYOD) i kombination med cloud computing. Författarna har kommit fram till sin slutsats genom att utföra intervjuer på två olika verksamheter samt en enkätundersökning som sedan har analyserats med aktuell teori. Utifrån detta har en kravspecifikation tagits fram som ett vägledande bidrag för organisationer. The aim of this thesis is to gain a richer insight into how informati...

Research on the Scattering Characteristics and the RCS Reduction of Circularly Polarized Microstrip Antenna

Directory of Open Access Journals (Sweden)

W. Jiang

2013-01-01

Full Text Available Based on the study of the radiation and scattering of the circularly polarized (CP antenna, a novel radar cross-section (RCS reduction technique is proposed for CP antenna in this paper. Quasi-fractal slots are applied in the design of the antenna ground plane to reduce the RCS of the CP antenna. Both prototype antenna and array are designed, and their time-, frequency-, and space-domain characteristics are studied to authenticate the proposed technique. The simulated and measured results show that the RCS of the prototype antenna and array is reduced up to 7.85 dB and 6.95 dB in the band of 1 GHz–10 GHz. The proposed technique serves a candidate in the design of low RCS CP antennas and arrays.

pubmed.mineR: an R package with text-mining algorithms to analyse PubMed abstracts.

Science.gov (United States)

Rani, Jyoti; Shah, A B Rauf; Ramachandran, Srinivasan

2015-10-01

The PubMed literature database is a valuable source of information for scientific research. It is rich in biomedical literature with more than 24 million citations. Data-mining of voluminous literature is a challenging task. Although several text-mining algorithms have been developed in recent years with focus on data visualization, they have limitations such as speed, are rigid and are not available in the open source. We have developed an R package, pubmed.mineR, wherein we have combined the advantages of existing algorithms, overcome their limitations, and offer user flexibility and link with other packages in Bioconductor and the Comprehensive R Network (CRAN) in order to expand the user capabilities for executing multifaceted approaches. Three case studies are presented, namely, 'Evolving role of diabetes educators', 'Cancer risk assessment' and 'Dynamic concepts on disease and comorbidity' to illustrate the use of pubmed.mineR. The package generally runs fast with small elapsed times in regular workstations even on large corpus sizes and with compute intensive functions. The pubmed.mineR is available at http://cran.rproject. org/web/packages/pubmed.mineR.

Effect of natural circulation on RCS depressurization strategy in PWR NPP

International Nuclear Information System (INIS)

Zhang Kun; Tong Lili; Cao Xuewu

2009-01-01

The natural circulation model of Chinese Qinshan Nuclear Power Plant (NPP) Unit 2 is built using SCDAP/RELAP5 code. Selecting TMLB' accident as the base sequence, this paper analyzes the natural circulation phenomena in high-pressure core melt severe accident. In order to study the effect of natural circulation on RCS depressurization strategy, the accident progressions of RCS depressurization with and without natural circulation are simulated, respectively. According to the results, the natural circulation can delay the initiation of RCS depressurization and the whole accident progression, but it does not evidently influence the results of RCS depressurization. (authors)

The Rcs regulon in Proteus mirabilis: implications for motility, biofilm formation, and virulence.

Science.gov (United States)

Howery, Kristen E; Clemmer, Katy M; Rather, Philip N

2016-11-01

The overall role of the Rcs phosphorelay in Proteus mirabilis is largely unknown. Previous work had demonstrated that the Rcs phosphorelay represses the flhDC operon and activates the minCDE cell division inhibition system. To identify additional cellular functions regulated by the Rcs phosphorelay, an analysis of RNA-seq data was undertaken. In this report, the results of the RNA-sequencing are discussed with an emphasis on the predicted roles of the Rcs phosphorelay in swarmer cell differentiation, motility, biofilm formation, and virulence. RcsB is shown to activate genes important for differentiation and fimbriae formation, while repressing the expression of genes important for motility and virulence. Additionally, to follow up on the RNA-Seq data, we demonstrate that an rcsB mutant is deficient in its ability to form biofilm and exhibits enhanced virulence in a Galleria mellonella waxworm model. Overall, these results indicate the Rcs regulon in P. mirabilis extends beyond flagellar genes to include those involved in biofilm formation and virulence. Furthermore, the information presented in this study may provide clues to additional roles of the Rcs phosphorelay in other members of the Enterobacteriaceae.

Survival and Functionality of hESC-Derived Retinal Pigment Epithelium Cells Cultured as a Monolayer on Polymer Substrates Transplanted in RCS Rats.

Science.gov (United States)

Thomas, Biju B; Zhu, Danhong; Zhang, Li; Thomas, Padmaja B; Hu, Yuntao; Nazari, Hossein; Stefanini, Francisco; Falabella, Paulo; Clegg, Dennis O; Hinton, David R; Humayun, Mark S

2016-05-01

To determine the safety, survival, and functionality of human embryonic stem cell-derived RPE (hESC-RPE) cells seeded on a polymeric substrate (rCPCB-RPE1 implant) and implanted into the subretinal (SR) space of Royal College of Surgeons (RCS) rats. Monolayers of hESC-RPE cells cultured on parylene membrane were transplanted into the SR space of 4-week-old RCS rats. Group 1 (n = 46) received vitronectin-coated parylene membrane without cells (rMSPM+VN), group 2 (n = 59) received rCPCB-RPE1 implants, and group 3 (n = 13) served as the control group. Animals that are selected based on optical coherence tomography screening were subjected to visual function assays using optokinetic (OKN) testing and superior colliculus (SC) electrophysiology. At approximately 25 weeks of age (21 weeks after surgery), the eyes were examined histologically for cell survival, phagocytosis, and local toxicity. Eighty-seven percent of the rCPCB-RPE1-implanted animals showed hESC-RPE survivability. Significant numbers of outer nuclear layer cells were rescued in both group 1 (rMSPM+VN) and group 2 (rCPCB-RPE1) animals. A significantly higher ratio of rod photoreceptor cells to cone photoreceptor cells was found in the rCPCB-RPE1-implanted group. Animals with rCPCB-RPE1 implant showed hESC-RPE cells containing rhodopsin-positive particles in immunohistochemistry, suggesting phagocytic function. Superior colliculus mapping data demonstrated that a significantly higher number of SC sites responded to light stimulus at a lower luminance threshold level in the rCPCB-RPE1-implanted group. Optokinetic data suggested both implantation groups showed improved visual acuity. These results demonstrate the safety, survival, and functionality of the hESC-RPE monolayer transplantation in an RPE dysfunction rat model.

Radar Cross Section (RCS) Simulation for Wind Turbines

Science.gov (United States)

2013-06-01

wind turbines are unsafe to operate. Also, helical wind turbines generally have less environmental concerns such as killing birds , especially in...SECTION (RCS) SIMULATION FOR WIND TURBINES by Cuong Ton June 2013 Thesis Advisor: David C. Jenn Second Reader: Ric Romero THIS PAGE...TITLE AND SUBTITLE RADAR CROSS SECTION (RCS) SIMULATION FOR WIND TURBINES 5. FUNDING NUMBERS 6. AUTHOR(S) Cuong Ton 7. PERFORMING ORGANIZATION

Ultra-wideband RCS reduction using novel configured chessboard metasurface

International Nuclear Information System (INIS)

Zhuang Ya-Qiang; Wang Guang-Ming; Xu He-Xiu

2017-01-01

A novel artificial magnetic conductor (AMC) metasurface is proposed with ultra-wideband 180° phase difference for radar cross section (RCS) reduction. It is composed of two dual-resonant AMC cells, which enable a broadband phase difference of 180°±30° from 7.9 GHz to 19.2 GHz to be achieved. A novel strategy is devised by dividing each rectangular grid in a chessboard configuration into four triangular grids, leading to a further reduction of peak bistatic RCS. Both full-wave simulation and measurement results show that the proposed metasurface presents a good RCS reduction property over an ultra-wideband frequency range. (paper)

Preliminary Research on RCS Using DGTD

Directory of Open Access Journals (Sweden)

Yang Qian

2015-06-01

Full Text Available Discontinuous Galerkin Time Domain (DGTD method appears to be very promising which combines the advantages of unstructured mesh in Finite Element Time Domain (FETD and explicit scheme in Finite Difference Time Domain (FDTD. This paper first describes principle of DGTD base on vector basis function. Secondly, Specific method for incident plane wave is given for scattering problem. At last, the monostatic Radar Cross Section (RCS of PEC sphere, medium sphere and the PEC bullet are computed by DGTD method. The numerical results illustrate the feasibility and correctness of the presented scheme. The study of this paper is a foundation for analyzing the RCS of complex target.

Tang med omtanke

DEFF Research Database (Denmark)

Schlundt, Jørgen

2013-01-01

Befolkningen bør kende både mulige positive og negative effekter af fødevarer, før de spiser dem. Det mener Jørgen Schlundt, DTU Fødevareinstituttet, med henvisning til Ole G. Mouritsens kritik af instituttets udmeldinger om tang i det seneste nummer af Aktuel Naturvidenskab.......Befolkningen bør kende både mulige positive og negative effekter af fødevarer, før de spiser dem. Det mener Jørgen Schlundt, DTU Fødevareinstituttet, med henvisning til Ole G. Mouritsens kritik af instituttets udmeldinger om tang i det seneste nummer af Aktuel Naturvidenskab....

76 FR 28914 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Science.gov (United States)

2011-05-19

... B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R Variant F Airplanes (Collectively... B4-605R and B4-622R airplanes; A300 F4-605R and F4-622R airplanes; A300 C4-605R Variant F airplanes...

Wideband RCS Reduction of Microstrip Array Antenna Based on Absorptive Frequency Selective Surface and Microstrip Resonators

Directory of Open Access Journals (Sweden)

Jingjing Xue

2017-01-01

Full Text Available An approach for wideband radar cross section (RCS reduction of a microstrip array antenna is presented and discussed. The scheme is based on the microstrip resonators and absorptive frequency selective surface (AFSS with a wideband absorptive property over the low band 1.9–7.5 GHz and a transmission characteristic at high frequency 11.05 GHz. The AFSS is designed to realize the out-of-band RCS reduction and preserve the radiation performance simultaneously, and it is placed above the antenna with the operating frequency of 11.05 GHz. Moreover, the microstrip resonators are loaded to obtain the in-band RCS reduction. As a result, a significant RCS reduction from 1.5 GHz to 13 GHz for both types of polarization has been accomplished. Compared with the reference antenna, the simulated results exhibit that the monostatic RCS of the proposed array antenna in x- and y-polarization can be reduced as much as 17.6 dB and 21.5 dB, respectively. And the measured results agree well with the simulated ones.

Betydningen af en række faktorer for døvfødte børn med CI

DEFF Research Database (Denmark)

Bengtsson, Steen; Larsen, Lena Bech

2014-01-01

Formålet med dette notat er ved hjælp af data fra SFI's undersøgelse af levevilkår for døvfødte børn med CI at belyse spørgsmålet om, hvad forskellige faktorer betyder for deres situation. Spørgsmålet er belyst ved at se på syv forhold, som repræsenterer forskellige sider af det resultat, som...... barnet har fået af CI-behandlingen. Vi belyser resultatet af behandlingen med spørgsmål, der giver vurderinger af: 1) barnets handicap, 2) barnets skolepræstationer, 3) barnets emotionelle forstyrrelser, 4) om barnet er en enspænder, 5) omfang af barnets besøg hos kammerater, 6) forældrenes bekymring...

Long non-coding RNA TUG1 promotes cell proliferation and metastasis by negatively regulating miR-300 in gallbladder carcinoma.

Science.gov (United States)

Ma, Fei; Wang, Shou-Hua; Cai, Qiang; Jin, Long-Yang; Zhou, Di; Ding, Jun; Quan, Zhi-Wei

2017-04-01

As we all know, long non-coding RNAs (lncRNAs) have been reported to play vital roles in various human cancers. In this study, we aimed to explore the role of lncRNA TUG1 in gallbladder carcinoma (GBC) development. Total RNA was extracted from the tissues of thirty GBC patients, four GBC cell lines. We detected the expression levels of TUG1 using quantitative real-time PCR. We performed CCK8, colony formation, transwell invasion and apoptosis assays to study the effects of TUG1 on GBC cell proliferation and invasion. Western blot assay was performed to assess to the expression level of epithelial-mesenchymal transition (EMT) markers in transforming growth factor-β1 (TGF-β1) treated and TUG1 knockdown GBC cell. Lastly, dual-luciferase reporter assay and quantitative real-time PCR were performed to verify the potential target microRNAs (miRNAs) of TUG1. TUG1 expression was significantly overexpressed in GBC tissues. Functionally, this study demonstrated that knockdown of TUG1 significantly inhibited GBC cell proliferation, metastasis. Mechanically, we found that TUG1 is upregulated by TGF-β1, and knockdown of TUG1 inhibited GBC cell EMT. Furthermore, we identified that miR-300, which has been reported as a suppressor in other types of cancer, is negatively regulated by TUG1. LncRNA TUG1 promotes GBC cell proliferation, metastasis and EMT progression by functioning as a miRNA sponge to abrogate the endogenous effect of miR-300. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

76 FR 27242 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Science.gov (United States)

2011-05-11

... Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R... applies to all Airbus Model A300 B4-601, B4-603, B4- 620, B4-622, B4-605R, B4-622R, F4-605R, F4-622R, and...

76 FR 59008 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Science.gov (United States)

2011-09-23

... Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R... to Airbus Model A300 B4-601, B4-603, B4-620, B4-622, B4-605R, B4-622R, F4-605R, F4-622R, and C4-605R...

Selskabsloven med kommentarer

DEFF Research Database (Denmark)

Schaumburg-Müller, Peer; Werlauff, Erik

Selskabsloven med kommentarer er bibelen på området for kapitalselskaber. Den er et juridisk arbejdsredskab for praktikere, rådgivere, forskere og studerende. Bogen indeholder en komplet opdatering af kommentarerne i forhold til de mange ændringer i selskabsloven siden 1.-udgaven, men bygger i øv...

A Multiple Model SNR/RCS Likelihood Ratio Score for Radar-Based Feature-Aided Tracking

National Research Council Canada - National Science Library

Slocumb, Benjamin J; Klusman, III, Michael E

2005-01-01

...) and radar cross section (RCS) for use in narrowband radar tracking. The formulation requires an estimate of the target mean RCS, and a key challenge is the tracking of the mean RCS through significant jumps due to aspect dependencies...

Ultra-Wideband RCS Reduction and Gain Enhancement of Aperture-Coupled Antenna Based on Hybrid-FSS

Directory of Open Access Journals (Sweden)

L. L. Cong

2017-12-01

Full Text Available A novel design of aperture-coupled microstrip antenna with ultra-wideband low radar cross section (RCS is proposed. Hybrid frequency selective surface (FSS structures consisting of two kinds of polarization-dependent folded split ring resonators (PDFSRRs and square patches are utilized to replace the conventional metallic ground. By orthogonally arranging the PDFSRRs in a chessboard-like configuration, the band-stop characteristic contributes to the gain enhancement, while the zero degree points of reflection phase and wave-transmission characteristic are utilized to achieve RCS reduction both in-band and out-of-band. Furthermore, with square patches periodically etched on the bottom of FSS structure, a new zero degree reflection phase is introduced to enhance the effect of RCS reduction. Full wave simulations and measurements demonstrate that the proposed antenna achieves RCS reduction from 1 GHz to 18 GHz and gain enhancement compared with traditional microstrip antenna.

Proteomic profiling of early degenerative retina of RCS rats.

Science.gov (United States)

Zhu, Zhi-Hong; Fu, Yan; Weng, Chuan-Huang; Zhao, Cong-Jian; Yin, Zheng-Qin

2017-01-01

To identify the underlying cellular and molecular changes in retinitis pigmentosa (RP). Label-free quantification-based proteomics analysis, with its advantages of being more economic and consisting of simpler procedures, has been used with increasing frequency in modern biological research. Dystrophic RCS rats, the first laboratory animal model for the study of RP, possess a similar pathological course as human beings with the diseases. Thus, we employed a comparative proteomics analysis approach for in-depth proteome profiling of retinas from dystrophic RCS rats and non-dystrophic congenic controls through Linear Trap Quadrupole - orbitrap MS/MS, to identify the significant differentially expressed proteins (DEPs). Bioinformatics analyses, including Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotation and upstream regulatory analysis, were then performed on these retina proteins. Finally, a Western blotting experiment was carried out to verify the difference in the abundance of transcript factor E2F1. In this study, we identified a total of 2375 protein groups from the retinal protein samples of RCS rats and non-dystrophic congenic controls. Four hundred thirty-four significantly DEPs were selected by Student's t -test. Based on the results of the bioinformatics analysis, we identified mitochondrial dysfunction and transcription factor E2F1 as the key initiation factors in early retinal degenerative process. We showed that the mitochondrial dysfunction and the transcription factor E2F1 substantially contribute to the disease etiology of RP. The results provide a new potential therapeutic approach for this retinal degenerative disease.

Proteomic profiling of early degenerative retina of RCS rats

Directory of Open Access Journals (Sweden)

Zhi-Hong Zhu

2017-06-01

Full Text Available AIM: To identify the underlying cellular and molecular changes in retinitis pigmentosa (RP. METHODS: Label-free quantification-based proteomics analysis, with its advantages of being more economic and consisting of simpler procedures, has been used with increasing frequency in modern biological research. Dystrophic RCS rats, the first laboratory animal model for the study of RP, possess a similar pathological course as human beings with the diseases. Thus, we employed a comparative proteomics analysis approach for in-depth proteome profiling of retinas from dystrophic RCS rats and non-dystrophic congenic controls through Linear Trap Quadrupole - orbitrap MS/MS, to identify the significant differentially expressed proteins (DEPs. Bioinformatics analyses, including Gene ontology (GO and Kyoto Encyclopedia of Genes and Genomes (KEGG pathway annotation and upstream regulatory analysis, were then performed on these retina proteins. Finally, a Western blotting experiment was carried out to verify the difference in the abundance of transcript factor E2F1. RESULTS: In this study, we identified a total of 2375 protein groups from the retinal protein samples of RCS rats and non-dystrophic congenic controls. Four hundred thirty-four significantly DEPs were selected by Student’s t-test. Based on the results of the bioinformatics analysis, we identified mitochondrial dysfunction and transcription factor E2F1 as the key initiation factors in early retinal degenerative process. CONCLUSION: We showed that the mitochondrial dysfunction and the transcription factor E2F1 substantially contribute to the disease etiology of RP. The results provide a new potential therapeutic approach for this retinal degenerative disease.

Ulykke med hækkesaks

DEFF Research Database (Denmark)

Leth, Peter Mygind

1996-01-01

Snitsår med blødning fra en overskåret pulsåre på armen forekommer hyppigt ved selvmordsforsøg, men har sjældent et dødeligt forløb. Her gives et eksempel på en isoleret partiel overklipning af a.ulnaris ved en ulykke med en hækkesaks med dødelig forløbende blødning.......Snitsår med blødning fra en overskåret pulsåre på armen forekommer hyppigt ved selvmordsforsøg, men har sjældent et dødeligt forløb. Her gives et eksempel på en isoleret partiel overklipning af a.ulnaris ved en ulykke med en hækkesaks med dødelig forløbende blødning....

Nostalgitrip med Pikachu

DEFF Research Database (Denmark)

Konzack, Lars

2016-01-01

Sommeren 2016 vil blive husket for den omsiggribende dille, Pokémon Go, med over 100 millioner downloads. Tusindvis af især børn og unge, men også forældre med barnevogne og hele familier, kunne pludselig ses på gader og stræder, i parker og grønne områder med en smartphone i hånden på jagt efter...

76 FR 18960 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Science.gov (United States)

2011-04-06

... B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R Variant F Airplanes (Collectively... July 20, 2005; have been performed in service. (2) Airbus Model A300 B4-605R, B4-622R, F4-605R, and F4... C4-600R, and A300 F4-600R series airplanes (fitted with a trim tank), all serial numbers, except...

Orbiter OMS and RCS technology

Science.gov (United States)

Boudreaux, R. A.

1982-01-01

Orbiter Orbital Maneuver Subsystem (OMS) and Reaction Control Subsystem (RCS) tankage has proved to be highly successful in shuttle flights on-orbit propellant transfer tests were done. Tank qualification tests along with flight demonstrations were carried out future uses of storable propellants are cited.

Ainooson et al., Afr J Tradit Complement Altern Med. (2012) 9(1):8 ...

African Journals Online (AJOL)

AJTCAM

Ainooson et al., Afr J Tradit Complement Altern Med. (2012) ..... The authors are grateful for the technical assistance offered by Messrs Thomas Ansah, Gordon Darku and George Ofei of ... Miller, J. R. (2003). ... R. Watson and V. R. Preedy.

Evaluation of High-Pressure RCS Natural Circulations Under Severe Accident Conditions

International Nuclear Information System (INIS)

Lee, Byung Chul; Bang, Young Suk; Suh, Nam Duk

2006-01-01

Since TMI-2 accident, the occurrence of severe accident natural circulations inside RCS during entire in-vessel core melt progressions before the reactor vessel breach had been emphasized and tried to clarify its thermal-hydraulic characteristics. As one of consolidated outcomes of these efforts, sophisticated models have been presented to explain the effects of a variety of engineering and phenomenological factors involved during severe accident mitigation on the integrity of RCS pressure boundaries, i.e. reactor pressure vessel(RPV), RCS coolant pipe and steam generator tubes. In general, natural circulation occurs due to density differences, which for single phase flow, is typically generated by temperature differences. Three natural circulation flows can be formed during severe accidents: in-vessel, hot leg countercurrent flow and flow through the coolant loops. Each of these flows may be present during high-pressure transients such as station blackout (SBO) and total loss of feedwater (TLOFW). As a part of research works in order to contribute on the completeness of severe accident management guidance (SAMG) in domestic plants by quantitatively assessing the RCS natural circulations on its integrity, this study presents basic approach for this work and some preliminary results of these efforts with development of appropriately detailed RCS model using MELCOR computer code

RCS estimation of linear and planar dipole phased arrays approximate model

CERN Document Server

Singh, Hema; Jha, Rakesh Mohan

2016-01-01

In this book, the RCS of a parallel-fed linear and planar dipole array is derived using an approximate method. The signal propagation within the phased array system determines the radar cross section (RCS) of phased array. The reflection and transmission coefficients for a signal at different levels of the phased-in scattering array system depend on the impedance mismatch and the design parameters. Moreover the mutual coupling effect in between the antenna elements is an important factor. A phased array system comprises of radiating elements followed by phase shifters, couplers, and terminating load impedance. These components lead to respective impedances towards the incoming signal that travels through them before reaching receive port of the array system. In this book, the RCS is approximated in terms of array factor, neglecting the phase terms. The mutual coupling effect is taken into account. The dependence of the RCS pattern on the design parameters is analyzed. The approximate model is established as a...

Annual Progress Report of the Department of Clinical Investigation, Reports Control Symbol MED-300(R-1), Fiscal Year 1992

Science.gov (United States)

1992-10-01

II. Acid Dissociation HPLC Analysis Of Dissociated iANF. Am J Physiol 261(4):E525-E528, 1991. *Published Abstracts* Agnew J, Freund BJ, Dubose D...1991. (C) Letterie GS, Sakas L: Histology Of Proximal Tubal Obstruction In Cases Of Unsuccessful Tubal Canalization. Fertil Steril 56(5):831-835, 1991...C) (SP) Orthopedic Service Green MR, Christensen KP, Embry R: Use of Magnetic Imaging of the Glenoid Labrum in Anterior Shoulder Instability. Am J

Med det sociale som designmateriale

DEFF Research Database (Denmark)

Brandt, Eva; Binder, Thomas

2016-01-01

Samarbejde, samskabelse og social nysgerrighed er i dag en præmis for den nyskabende designer. Det sociale er det nye designmateriale som unge designere giver sig i kast med når f.eks. Emmy Linde samarbejder med plejehjemsbeboere, deres pårørende, plejepersonale og fysioterapeuter for at designe ...

Arbejdspladsvurdering i små virksomheder med 1-4 ansatte

DEFF Research Database (Denmark)

Hasle, Peter; Esben, Dalskinn

En analyse af mulighederne for at gennemføre arbejdspladsvurdering i mikrovirksomheder med 1-4 ansatte.......En analyse af mulighederne for at gennemføre arbejdspladsvurdering i mikrovirksomheder med 1-4 ansatte....

A Disulfide Bond in the Membrane Protein IgaA Is Essential for Repression of the RcsCDB System

Directory of Open Access Journals (Sweden)

M. Graciela Pucciarelli

2017-12-01

Full Text Available IgaA is an integral inner membrane protein that was discovered as repressor of the RcsCDB phosphorelay system in the intracellular pathogen Salmonella enterica serovar Typhimurium. The RcsCDB system, conserved in many members of the family Enterobacteriaceae, regulates expression of varied processes including motility, biofilm formation, virulence and response to envelope stress. IgaA is an essential protein to which, in response to envelope perturbation, the outer membrane lipoprotein RcsF has been proposed to bind in order to activate the RcsCDB phosphorelay. Envelope stress has also been reported to be sensed by a surface exposed domain of RcsF. These observations support a tight control of the RcsCDB system by RcsF and IgaA via mechanisms that, however, remain unknown. Interestingly, RcsF and IgaA have four conserved cysteine residues in loops exposed to the periplasmic space. Two non-consecutive disulfide bonds were shown to be required for RcsF function. Here, we report mutagenesis studies supporting the presence of one disulfide bond (C404-C425 in the major periplasmic loop of IgaA that is essential for repression of the RcsCDB phosphorelay. Our data therefore suggest that the redox state of the periplasm may be critical for the control of the RcsCDB system by its two upstream regulators, RcsF and IgaA.

Expression of nitric oxide synthase during the development of RCS rat retinas.

Science.gov (United States)

Sharma, R K; Warfvinge, K; Ehinger, B

2001-01-01

Nitric oxide (NO) has been reported to be both neurodestructive and neuroprotective in the central nervous system and could possibly play an important role in neurodegenerative disorders. On the assumption that NO synthesis may influence degenerative processes in the retina, we have examined the development and distribution of nitric-oxide-synthase(NOS)-immunoreactive cells in developing Royal College of Surgeons (RCS) rat retinas, which is an animal model for retinal degeneration. An antibody against constitutive neuronal NOS was used for immunocytochemistry on RCS rat retinas from postnatal (PN) days 3, 7, 10, 14, 35, 70 and 281 and compared with that in the normal rats of PN days 3, 7, 10, 14, 54 and adults. Immunoreactive cells were not seen in PN 3 retinas but were distinctly seen in the PN 7 retina along with a plexus in the inner plexiform layer. In both groups (normal and RCS rats) a distinct sublayering of the plexus in the inner plexiform layer could be seen at PN 10, which became more distinct at PN 14. The immunoreactive cells were detected also in the oldest retina examined, which was PN 281 in the case of RCS rats. In both groups, certain amacrine cells, certain bipolar cells and certain horizontal cells were found to be immunoreactive. In conclusion, the developmental timetable of the NOS immunoreactivity was identical in the normal and the RCS rat retinas. The NOS-immunoreactive cells persisted in the RCS retinas even when the retina had degenerated extensively. Abnormalities with the inducible isoforms of NOS cannot be ruled out from this study. We conclude that the chronological and qualitative development of the constitutive neuronal NOS immunoreactivity is normal in RCS rat retinas. Copyright 2001 S. Karger AG, Basel

An efficient hybrid technique in RCS predictions of complex targets at high frequencies

Science.gov (United States)

Algar, María-Jesús; Lozano, Lorena; Moreno, Javier; González, Iván; Cátedra, Felipe

2017-09-01

Most computer codes in Radar Cross Section (RCS) prediction use Physical Optics (PO) and Physical theory of Diffraction (PTD) combined with Geometrical Optics (GO) and Geometrical Theory of Diffraction (GTD). The latter approaches are computationally cheaper and much more accurate for curved surfaces, but not applicable for the computation of the RCS of all surfaces of a complex object due to the presence of caustic problems in the analysis of concave surfaces or flat surfaces in the far field. The main contribution of this paper is the development of a hybrid method based on a new combination of two asymptotic techniques: GTD and PO, considering the advantages and avoiding the disadvantages of each of them. A very efficient and accurate method to analyze the RCS of complex structures at high frequencies is obtained with the new combination. The proposed new method has been validated comparing RCS results obtained for some simple cases using the proposed approach and RCS using the rigorous technique of Method of Moments (MoM). Some complex cases have been examined at high frequencies contrasting the results with PO. This study shows the accuracy and the efficiency of the hybrid method and its suitability for the computation of the RCS at really large and complex targets at high frequencies.

Rätten till självbestämmande : Samernas rättigheter i samband med mineralutvinning

OpenAIRE

Lindström, Emelie

2015-01-01

Idag etablerar sig flertalet gruvbolag i Sverige på marker som även är av intresse för samernaoch den rennäring som de bedriver på markerna. Denna uppsats belyser det regelverk sombehandlar de rättigheter samerna, som urbefolkning, har gentemot Sverige. Sverige har fåttskarp kritik från FN: s rasdiskrimineringskommitté (CERD) för att samernas rättigheter somurbefolkning inte skyddas tillräckligt i samband med den mineralutvinning som pågår iSápmi. Främst riktas kritiken mot att samerna inte k...

Sker der noget med læringdudbyttet, når undervisningssproget skiftes?

Directory of Open Access Journals (Sweden)

Camilla Falk Rønne Nissen

2016-04-01

Full Text Available I takt med en øget internationalisering af de videregående uddannelser øges mængden af undervisning på engelsk på de danske universiteter. Men hvilke konsekvenser har det for kvaliteten af undervisningen? Falder læringsudbyttet, når der undervises på et sprog, der for de fleste universitetsstuderende og undervisere ikke er deres førstesprog? Denne artikel prøver gennem et litteraturreview at finde svar i den eksisterende, forskningsbaserede litteratur. Første del af reviewet identificerer interesseområder i forskningen, mens anden del gennemgår resultater fra enkelte studier med fokus på læring og deltagelse, særligt i en nordisk kontekst. The internationalization of higher education has driven Danish universities to increase the amount of teaching in English. But what are the consequences for the quality of the education? Is the quality of the learning outcome compromised when teaching and learning activities take place in a second language? Based on a literature review of existing, research-based literature, this article tries to offer some answers to that question. The first part of the review identifies different research interests, while the second part of the review discusses results from selected studies that have focused on student learning and activity, especially within a Nordic setting.

Detailed evaluation of RCS boundary rupture during high-pressure severe accident sequences

International Nuclear Information System (INIS)

Park, Rae-Joon; Hong, Seong-Wan

2011-01-01

A depressurization possibility of the reactor coolant system (RCS) before a reactor vessel rupture during a high-pressure severe accident sequence has been evaluated for the consideration of direct containment heating (DCH) and containment bypass. A total loss of feed water (TLOFW) and a station blackout (SBO) of the advanced power reactor 1400 (APR 1400) has been evaluated from an initiating event to a creep rupture of the RCS boundary by using the SCDAP/RELAP5 computer code. In addition, intentional depressurization of the RCS using power-operated safety relief valves (POSRVs) has been evaluated. The SCDAPRELAP5 results have shown that the pressurizer surge line broke before the reactor vessel rupture failure, but a containment bypass did not occur because steam generator U tubes did not break. The intentional depressurization of the RCS using POSRV was effective for the DCH prevention at a reactor vessel rupture. (author)

Integrable RCS as a Proposed Replacement for Fermilab Booster

Energy Technology Data Exchange (ETDEWEB)

Eldred, Jeffrey [Fermilab; Valishev, Alexander [Fermilab

2017-03-07

Integrable optics is an innovation in particle accelerator design that potentially enables a greater betatron tune spread and damps collective instabilities. An integrable rapid-cycling synchrotron (RCS) would be an effective replacement for the Fermilab Booster, as part of a plan to reach multi-MW beam power at 120 GeV for the Fermilab high-energy neutrino program. We provide an example integrable lattice with features of a modern RCS - dispersion-free drifts, low momentum compaction factor, superperiodicity, chromaticity correction, bounded beta functions, and separate-function magnets.

Regulation of the Min Cell Division Inhibition Complex by the Rcs Phosphorelay in Proteus mirabilis.

Science.gov (United States)

Howery, Kristen E; Clemmer, Katy M; Şimşek, Emrah; Kim, Minsu; Rather, Philip N

2015-08-01

A key regulator of swarming in Proteus mirabilis is the Rcs phosphorelay, which represses flhDC, encoding the master flagellar regulator FlhD4C2. Mutants in rcsB, the response regulator in the Rcs phosphorelay, hyperswarm on solid agar and differentiate into swarmer cells in liquid, demonstrating that this system also influences the expression of genes central to differentiation. To gain a further understanding of RcsB-regulated genes involved in swarmer cell differentiation, transcriptome sequencing (RNA-Seq) was used to examine the RcsB regulon. Among the 133 genes identified, minC and minD, encoding cell division inhibitors, were identified as RcsB-activated genes. A third gene, minE, was shown to be part of an operon with minCD. To examine minCDE regulation, the min promoter was identified by 5' rapid amplification of cDNA ends (5'-RACE), and both transcriptional lacZ fusions and quantitative real-time reverse transcriptase (qRT) PCR were used to confirm that the minCDE operon was RcsB activated. Purified RcsB was capable of directly binding the minC promoter region. To determine the role of RcsB-mediated activation of minCDE in swarmer cell differentiation, a polar minC mutation was constructed. This mutant formed minicells during growth in liquid, produced shortened swarmer cells during differentiation, and exhibited decreased swarming motility. This work describes the regulation and role of the MinCDE cell division system in P. mirabilis swarming and swarmer cell elongation. Prior to this study, the mechanisms that inhibit cell division and allow swarmer cell elongation were unknown. In addition, this work outlines for the first time the RcsB regulon in P. mirabilis. Taken together, the data presented in this study begin to address how P. mirabilis elongates upon contact with a solid surface. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Subretinal electrical stimulation preserves inner retinal function in RCS rat retina.

Science.gov (United States)

Ciavatta, Vincent T; Mocko, Julie A; Kim, Moon K; Pardue, Machelle T

2013-01-01

Previously, studies showed that subretinal electrical stimulation (SES) from a microphotodiode array (MPA) preserves electroretinography (ERG) b-wave amplitude and regional retinal structure in the Royal College of Surgeons (RCS) rat and simultaneously upregulates Fgf2 expression. This preservation appears to be associated with the increased current produced when the MPA is exposed to ERG test flashes, as weekly ERG testing produces greater neuroprotection than biweekly or no testing. Using an infrared source to stimulate the MPA while avoiding potential confounding effects from exposing the RCS retina to high luminance white light, this study examined whether neuroprotective effects from SES increased with subretinal current in a dose-dependent manner. RCS rats (n=49) underwent subretinal implantation surgery at P21 with MPA devices in one randomly selected eye, and the other eye served as the control. Naïve RCS rats (n=25) were also studied. To increase SES current levels, implanted eyes were exposed to 15 min per session of flashing infrared light (IR) of defined intensity, frequency, and duty cycle. Rats were divided into four SES groups that received ERG testing only (MPA only), about 450 µA/cm2 once per week (Low 1X), about 450 µA/cm2 three times per week (Low 3X), and about 1350 µA/cm2 once per week (High 1X). One eye of the control animals was randomly chosen for IR exposure. All animals were followed for 4 weeks with weekly binocular ERGs. A subset of the eyes was used to measure retina Fgf2 expression with real-time reverse-transcription PCR. Eyes receiving SES showed significant preservation of b-wave amplitude, a- and b-wave implicit times, oscillatory potential amplitudes, and post-receptoral parameters (Vmax and log σ) compared to untreated eyes. All SES-treated eyes had similar preservation, regardless of increased SES from IR light exposure. SES-treated eyes tended to have greater retinal Fgf2 expression than untreated eyes, but Fgf2 expression

Antichrist - Anti-Ødipus. Et essay om Triers opgør med den symbolske orden

DEFF Research Database (Denmark)

Carlsen, Benny Bang

2012-01-01

I essayet indkredses først receptionen af filmen "Antichrist" og dens virkningshistorie gennem en række udvalgte eksempler. Dernæst trækker essayet filmens påvirkninger og mulige inspirationskilder frem i lyset, bl.a. gennem Nietzsches filosofi og Lacans psykoanalyse. Herefter analyseres filmen m...... baggrund i Derridas dekonstruktionsbegreb, Genettes fokaliseringsbegreb samt Grodals kognitive semiotisk funderede receptionsanalyse. Endelig diskuteres filmens budskab med inddragelse af en række filosoffer bl.a. Heidegger, Deleuzes m.fl....

Clinical Investigation Program, Reports Control Symbol MED-300(R1), Fiscal Year 1988

Science.gov (United States)

1988-10-01

MOREAU GORDON A, BOUCEK ROBERT Jr, GRAHAM THOMAS P Jr: "Acute shift of right ventricular distensibility after balloon pulmonary valvuloplasty"/Washington...allowing dynamic torsional forces to be recorded at set velocities throughout a pre-selected range of motion using both concentric and eccentric muscular

Uneven-Layered Coding Metamaterial Tile for Ultra-wideband RCS Reduction and Diffuse Scattering.

Science.gov (United States)

Su, Jianxun; He, Huan; Li, Zengrui; Yang, Yaoqing Lamar; Yin, Hongcheng; Wang, Junhong

2018-05-25

In this paper, a novel uneven-layered coding metamaterial tile is proposed for ultra-wideband radar cross section (RCS) reduction and diffuse scattering. The metamaterial tile is composed of two kinds of square ring unit cells with different layer thickness. The reflection phase difference of 180° (±37°) between two unit cells covers an ultra-wide frequency range. Due to the phase cancellation between two unit cells, the metamaterial tile has the scattering pattern of four strong lobes deviating from normal direction. The metamaterial tile and its 90-degree rotation can be encoded as the '0' and '1' elements to cover an object, and diffuse scattering pattern can be realized by optimizing phase distribution, leading to reductions of the monostatic and bi-static RCSs simultaneously. The metamaterial tile can achieve -10 dB RCS reduction from 6.2 GHz to 25.7 GHz with the ratio bandwidth of 4.15:1 at normal incidence. The measured and simulated results are in good agreement and validate the proposed uneven-layered coding metamaterial tile can greatly expanding the bandwidth for RCS reduction and diffuse scattering.

On the radar cross section (RCS) prediction of vehicles moving on the ground

Energy Technology Data Exchange (ETDEWEB)

Sabihi, Ahmad [Department of Mathematical Sciences, Sharif University of Technology, Tehran (Iran, Islamic Republic of)

2014-12-10

As readers should be aware, Radar Cross Section depends on the factors such as: Wave frequency and polarization, Target dimension, angle of ray incidence, Target’s material and covering, Type of radar system as monostatic or bistatic, space in which contains target and propagating waves, and etc. Having moved or stationed in vehicles can be effective in RCS values. Here, we investigate effective factors in RCS of moving targets on the ground or sea. Image theory in electromagnetic applies to be taken into account RCS of a target over the ground or sea.

On the radar cross section (RCS) prediction of vehicles moving on the ground

International Nuclear Information System (INIS)

Sabihi, Ahmad

2014-01-01

As readers should be aware, Radar Cross Section depends on the factors such as: Wave frequency and polarization, Target dimension, angle of ray incidence, Target’s material and covering, Type of radar system as monostatic or bistatic, space in which contains target and propagating waves, and etc. Having moved or stationed in vehicles can be effective in RCS values. Here, we investigate effective factors in RCS of moving targets on the ground or sea. Image theory in electromagnetic applies to be taken into account RCS of a target over the ground or sea

Layer-specific blood-flow MRI of retinitis pigmentosa in RCS rats☆

Science.gov (United States)

Li, Guang; Garza, Bryan De La; Shih, Yen-Yu I.; Muir, Eric R.; Duong, Timothy Q.

2013-01-01

The Royal College of Surgeons (RCS) rat is an established animal model of retinitis pigmentosa, a family of inherited retinal diseases which starts with loss of peripheral vision and progresses to eventual blindness. Blood flow (BF), an important physiological parameter, is intricately coupled to metabolic function under normal physiological conditions and is perturbed in many neurological and retinal diseases. This study reports non-invasive high-resolution MRI (44 × 44 × 600 μm) to image quantitative retinal and choroidal BF and layer-specific retinal thicknesses in RCS rat retinas at different stages of retinal degeneration compared with age-matched controls. The unique ability to separate retinal and choroidal BF was made possible by the depth-resolved MRI technique. RBF decreased with progressive retinal degeneration, but ChBF did not change in RCS rats up to post-natal day 90. We concluded that choroidal and retinal circulations have different susceptibility to progressive retinal degeneration in RCS rats. Layer-specific retinal thickness became progressively thinner and was corroborated by histological analysis in the same animals. MRI can detect progressive anatomical and BF changes during retinal degeneration with laminar resolution. PMID:22721720

Layer-specific blood-flow MRI of retinitis pigmentosa in RCS rats.

Science.gov (United States)

Li, Guang; De La Garza, Bryan; Shih, Yen-Yu I; Muir, Eric R; Duong, Timothy Q

2012-08-01

The Royal College of Surgeons (RCS) rat is an established animal model of retinitis pigmentosa, a family of inherited retinal diseases which starts with loss of peripheral vision and progresses to eventual blindness. Blood flow (BF), an important physiological parameter, is intricately coupled to metabolic function under normal physiological conditions and is perturbed in many neurological and retinal diseases. This study reports non-invasive high-resolution MRI (44 × 44 × 600 μm) to image quantitative retinal and choroidal BF and layer-specific retinal thicknesses in RCS rat retinas at different stages of retinal degeneration compared with age-matched controls. The unique ability to separate retinal and choroidal BF was made possible by the depth-resolved MRI technique. RBF decreased with progressive retinal degeneration, but ChBF did not change in RCS rats up to post-natal day 90. We concluded that choroidal and retinal circulations have different susceptibility to progressive retinal degeneration in RCS rats. Layer-specific retinal thickness became progressively thinner and was corroborated by histological analysis in the same animals. MRI can detect progressive anatomical and BF changes during retinal degeneration with laminar resolution. Copyright © 2012 Elsevier Ltd. All rights reserved.

An Ultra-wideband and Polarization-independent Metasurface for RCS Reduction.

Science.gov (United States)

Su, Pei; Zhao, Yongjiu; Jia, Shengli; Shi, Wenwen; Wang, Hongli

2016-02-11

In this paper, an ultra-wideband and polarization-independent metasurface for radar cross section (RCS) reduction is proposed. The unit cell of the metasurface operates in a linear cross-polarization scheme in a broad band. The phase and amplitude of cross-polarized reflection can be separately controlled by its geometry and rotation angle. Based on the diffuse reflection theory, a 3-bit coding metasurface is designed to reduce the RCS in an ultra-wide band. The wideband property of the metasurface benefits from the wideband cross polarization conversion and flexible phase modulation. In addition, the polarization-independent feature of the metasurface is achieved by tailoring the rotation angle of each element. Both the simulated and measured results demonstrate that the proposed metasurface can reduce the RCS significantly in an ultra-wide frequency band for both normal and oblique incidences, which makes it promising in the applications such as electromagnetic cloaking.

Analys av nickel med ICP-MS

OpenAIRE

Wallman, Karin; Löfgren, Stefan; Sonesten, Lars; Demandt, Christian

2009-01-01

Vid en granskning av nickelhalter för perioden 1985-2007 upptäcktes ett nivåskifte i tidsserierna på flera stationer mellan 2001 och 2002. Skiftet visade sig bero på att prover innan 2002 inte korrigerades för kalciuminterferens, medan prover under åren 2002-2007 korrigerades. Syftet med denna rapport är att utreda om resultaten före 2002 i efterhand kan korrigeras för kalciuminterferensen. Från 2002 finns ett antal prover (N=347) med resultat som både är kalciumkorrigerade och som inte är de...

Bioinformatics, interaction network analysis, and neural networks to characterize gene expression of radicular cyst and periapical granuloma.

Science.gov (United States)

Poswar, Fabiano de Oliveira; Farias, Lucyana Conceição; Fraga, Carlos Alberto de Carvalho; Bambirra, Wilson; Brito-Júnior, Manoel; Sousa-Neto, Manoel Damião; Santos, Sérgio Henrique Souza; de Paula, Alfredo Maurício Batista; D'Angelo, Marcos Flávio Silveira Vasconcelos; Guimarães, André Luiz Sena

2015-06-01

Bioinformatics has emerged as an important tool to analyze the large amount of data generated by research in different diseases. In this study, gene expression for radicular cysts (RCs) and periapical granulomas (PGs) was characterized based on a leader gene approach. A validated bioinformatics algorithm was applied to identify leader genes for RCs and PGs. Genes related to RCs and PGs were first identified in PubMed, GenBank, GeneAtlas, and GeneCards databases. The Web-available STRING software (The European Molecular Biology Laboratory [EMBL], Heidelberg, Baden-Württemberg, Germany) was used in order to build the interaction map among the identified genes by a significance score named weighted number of links. Based on the weighted number of links, genes were clustered using k-means. The genes in the highest cluster were considered leader genes. Multilayer perceptron neural network analysis was used as a complementary supplement for gene classification. For RCs, the suggested leader genes were TP53 and EP300, whereas PGs were associated with IL2RG, CCL2, CCL4, CCL5, CCR1, CCR3, and CCR5 genes. Our data revealed different gene expression for RCs and PGs, suggesting that not only the inflammatory nature but also other biological processes might differentiate RCs and PGs. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

41 CFR 300-1.1 - What is the FTR?

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What is the FTR? 300-1.1 Section 300-1.1 Public Contracts and Property Management Federal Travel Regulation System GENERAL INTRODUCTION 1-THE FEDERAL TRAVEL REGULATION (FTR) § 300-1.1 What is the FTR? The FTR is the regulation...

A marvel of precision: MedAustron

CERN Document Server

Anaïs Schaeffer

2013-01-01

MedAustron, which is currently being built in Austria, will be one of the most advanced centres for ion beam therapy and research in Europe. It is based on the same design as the Italian National Centre for Oncological Hadrontherapy (CNAO), which in turn is based on the CERN-led Proton Ion Medical Machine Study (PIMMS). MedAustron should welcome its first patient at the end of 2015.   Layout of the MedAustron accelerator complex.  With three ion-sources, a linac, a synchrotron and four irradiation rooms (see picture), MedAustron is a huge accelerator complex. Among other equipment, it comprises 300 magnets of 30 different types, all designed at CERN but produced at different sites: “We are working with five main suppliers from Europe and Russia,” explains Thomas Zickler, leader of the MedAustron magnet group. “All the magnets come to CERN to undergo a series of strict acceptance tests.” From the interfaces, to the electrical insulation, the co...

An investigation of the RCS (radar cross section) computation of grid cavities

International Nuclear Information System (INIS)

Sabihi, Ahmad

2014-01-01

In this paper, the aperture of a cavity is covered by a metallic grid net. This metallic grid is to reduce RCS deduced by impinging radar ray on the aperture. A radar ray incident on a grid net installed on a cavity may create six types of propagation. 1-Incident rays entering inside the cavity and backscattered from it.2-Incidebnt rays on the grid net and created reection rays as an array of scatterers. These rays may create a wave with phase difference of 180 degree with respect to the exiting rays from the cavity.3-Incident rays on the grid net create surface currents owing on the net and make travelling waves, which regenerate the magnetic and electric fields. These fields make again propagated waves against incident ones.4-Creeping waves.5-Diffracted rays due to leading edges of net’s elements.6-Mutual impedance among elements of the net could be effective on the resultant RCS. Therefore, the author compares the effects of three out of six properties to a cavity without grid net. This comparison shows that RCS prediction of cavity having a grid net is much more reduced than that of without one

An investigation of the RCS (radar cross section) computation of grid cavities

Energy Technology Data Exchange (ETDEWEB)

Sabihi, Ahmad [Department of Mathematical Sciences, Sharif University of Technology, Tehran (Iran, Islamic Republic of)

2014-12-10

In this paper, the aperture of a cavity is covered by a metallic grid net. This metallic grid is to reduce RCS deduced by impinging radar ray on the aperture. A radar ray incident on a grid net installed on a cavity may create six types of propagation. 1-Incident rays entering inside the cavity and backscattered from it.2-Incidebnt rays on the grid net and created reection rays as an array of scatterers. These rays may create a wave with phase difference of 180 degree with respect to the exiting rays from the cavity.3-Incident rays on the grid net create surface currents owing on the net and make travelling waves, which regenerate the magnetic and electric fields. These fields make again propagated waves against incident ones.4-Creeping waves.5-Diffracted rays due to leading edges of net’s elements.6-Mutual impedance among elements of the net could be effective on the resultant RCS. Therefore, the author compares the effects of three out of six properties to a cavity without grid net. This comparison shows that RCS prediction of cavity having a grid net is much more reduced than that of without one.

Fault-tolerant control with mixed aerodynamic surfaces and RCS jets for hypersonic reentry vehicles

Directory of Open Access Journals (Sweden)

Jingjing He

2017-04-01

Full Text Available This paper proposes a fault-tolerant strategy for hypersonic reentry vehicles with mixed aerodynamic surfaces and reaction control systems (RCS under external disturbances and subject to actuator faults. Aerodynamic surfaces are treated as the primary actuator in normal situations, and they are driven by a continuous quadratic programming (QP allocator to generate torque commanded by a nonlinear adaptive feedback control law. When aerodynamic surfaces encounter faults, they may not be able to provide sufficient torque as commanded, and RCS jets are activated to augment the aerodynamic surfaces to compensate for insufficient torque. Partial loss of effectiveness and stuck faults are considered in this paper, and observers are designed to detect and identify the faults. Based on the fault identification results, an RCS control allocator using integer linear programming (ILP techniques is designed to determine the optimal combination of activated RCS jets. By treating the RCS control allocator as a quantization element, closed-loop stability with both continuous and quantized inputs is analyzed. Simulation results verify the effectiveness of the proposed method.

The analysis of SCS return momentum effects on the RCS water level during mid-loop operations

Energy Technology Data Exchange (ETDEWEB)

swang Seo, J.; Young Yang, J.; Tack Hwang, S. [Seoul National Univ. (Korea, Republic of)

1995-09-01

An accurate prediction of Reactor Coolant System (RCS) water levels is of importance in the determination of allowable operating range to ensure the safety during the mid-loop operations. However, complex hydraulic phenomena induced by Shutdown Cooling System (SCS) return momentum cause different water levels from those in the loop where the water level indicators are located. This was apparantly observed at the pre-core cold hydro test of the Younggwang Nuclear Unit 3 (YGN 3) in Korea. In this study, in order to analytically understand the effect of the SCS return momentum on the RCS water level and its general trend, a model using one-dimensional momentum equation, hydraulic jump, Bernoulli equation, flow resistance coefficient, and total water volume conservation has been developed to predict the RCS water levels at various RCS locations during the mid-loop conditions and the simulation results were compared with the test data. The analysis shows that the hydraulic jump in the operating cold legs in conjunction with the momentum loss throughout the RCS is the main cause creating the water level differences at various RCS locations. The prediction results provide good explanations for the test data and show the significant effect of the SCS return momentum on the RCS water levels.

The analysis of SCS return momentum effects on the RCS water level during mid-loop operations

International Nuclear Information System (INIS)

swang Seo, J.; Young Yang, J.; Tack Hwang, S.

1995-01-01

An accurate prediction of Reactor Coolant System (RCS) water levels is of importance in the determination of allowable operating range to ensure the safety during the mid-loop operations. However, complex hydraulic phenomena induced by Shutdown Cooling System (SCS) return momentum cause different water levels from those in the loop where the water level indicators are located. This was apparantly observed at the pre-core cold hydro test of the Younggwang Nuclear Unit 3 (YGN 3) in Korea. In this study, in order to analytically understand the effect of the SCS return momentum on the RCS water level and its general trend, a model using one-dimensional momentum equation, hydraulic jump, Bernoulli equation, flow resistance coefficient, and total water volume conservation has been developed to predict the RCS water levels at various RCS locations during the mid-loop conditions and the simulation results were compared with the test data. The analysis shows that the hydraulic jump in the operating cold legs in conjunction with the momentum loss throughout the RCS is the main cause creating the water level differences at various RCS locations. The prediction results provide good explanations for the test data and show the significant effect of the SCS return momentum on the RCS water levels

Et felteksperiment med Kærlighed i Kaos

DEFF Research Database (Denmark)

Christensen, Christiane Præstgaard; Scavenius Sonne-Schmidt, Christoffer

Som et nyt tilbud til danske forældre med børn med ADHD og ADHD-lignende vanskeligheder har ADHDforeningen udviklet forældretræningsprogrammet Kærlighed i Kaos, hvor frivillige hjælper forældre til børn med ADHD, der står med et særligt vanskeligt opdragelsesarbejde. Denne rapport har til formål......, når forældrene stiller krav til børnene. Resultaterne i denne rapport har interesse for fagpersoner, behandlere, undervisere, beslutningstagere, frivillige organisationer, foreninger og de mange nuværende og kommende familier, som dagligt kæmper med adfærdsvanskeligheder – såsom ADHD. Effektmålingen...

75 FR 7942 - Airworthiness Directives; Airbus Model A310-203, -221, -222 Airplanes; and Model A300 F4-605R and...

Science.gov (United States)

2010-02-23

... Airworthiness Directives; Airbus Model A310-203, -221, -222 Airplanes; and Model A300 F4-605R and -622R...-222 airplanes, all serial numbers. (2) Airbus Model A300 F4-605R and A300 F4-622R airplanes, all...

Automation med pneumatiske servodrev - status og fremtid

DEFF Research Database (Denmark)

Sørensen, Paul Haase

1996-01-01

Der er råd for problemer med ulineariteter. Med de nyeste metoder kan der lineære driftsområde udvides. Men pneumatikkomponenter skal være af høj kvalitet, når positionering skal være nøjagtig....

Pulseshape characteristics of a 300 $\\mu$m PR03 R-measuring VELO sensor read out with a Beetle1.3 chip

CERN Document Server

Palacios, A; Buytaert, J; Borel, J; Collins, P; Eckstein, D; Eklund, L; Ferro-Luzzi, M; Jans, E; Ketel, T; Petrie, D; Pivk, M; Tobin, M

2005-01-01

The signal-to-noise, overspill and undershoot characteristics of a VELO module equipped with Beetle1.3 read-out chips have been measured using 120 GeV pions from the SPS test beam facility at CERN. The module consists of a PR03 n-on-n 300 $\\mu$m R measuring prototype sensor and a fully populated K03 hybrid. Results are presented for a single Beetle1.3 chip with a variety of chip parameter settings controlling the pre-amplifier and shaper currents and feedback voltages, with the objective of establishing the performance of the module and understanding its dependence on the read-out chip settings.

Design and Implementation of Adaptive Turbo Encoder for Quantized Software Defined Low-Power DVB-RCS Radios

Directory of Open Access Journals (Sweden)

S. H. Elramly

2010-11-01

Full Text Available Turbo codes are employed in every robust wireless digital communications system. Those codes have been adopted for the satellite return channel in DVB-RCS (Return Channel via Satellite standard. In Software Defined Radios (SDRs, Field Programmable Gate Array technology (FPGA is considered a highly configurable option for implementing many sophisticated signal processing tasks. The implementation for such codes is complex and dissipates a large amount of power. This paper studies the efficient implementation of quantized DVB-RCS turbo coding. Also, a low-power, turbo encoder for DVB-RCS is described using a VHDL code. The proposed encoder design is implemented on Xilinx Virtex-II Pro, XC2vpx30 FPGA chip. FPGA Advantage Pro package provided by Mentor Graphics is used for VHDL description and ISE 10.1 by Xilinx is used for synthetization.

Experimental benchmarks and simulation of GAMMA-T for overcooling and undercooling transients in HTGRs coupled with MED desalination plants

International Nuclear Information System (INIS)

Kim, Ho Sik; Kim, In Hun; NO, Hee Cheon; Jin, Hyung Gon

2013-01-01

Highlights: ► The GAMMA-T code was well validated through benchmark experiments. ► Based on the KAIST coupling scheme, the GTHTR300 + MED systems were made. ► Safety analysis was performed for overcooling and undercooling accidents. ► In all accidents, maximum peak fuel temperatures were well below than 1600 °C. ► In all accidents, the HTGR + MED system could be operated continuously. -- Abstracts: The nuclear desalination based on the high temperature gas-cooled reactor (HTGR) with gas turbomachinery and multi-effect distillation (MED) is attracting attention because the coupling system can utilize the waste heat of the nuclear power system for the MED desalination system. In previous work, KAIST proposed the new HTGR + MED coupling scheme, evaluated desalination performance, and performed cost analysis for the system. In this paper, in order to confirm the safety and the performance of the coupling system, we performed the transient analysis with GAMMA-T (GAs Multidimensional Multicomponent mixture Analysis–Turbomachinery) code for the KAIST HTGR + MED systems. The experimental benchmarks of GAMMA-T code were set up before the transient analysis for several accident scenarios. The GAMMA-T code was well validated against steady state and transient scenarios of the He–Water test loop such as changes in water mass flow rate and water inlet temperatures. Then, for transient analysis, the GTHTR300 was chosen as a reference plant. The GTHTR300 + MED systems were made, based on the KAIST HTGR + MED coupling scheme. Transient analysis was performed for three kinds of accidents scenarios: (1) loss of heat rejection through MED plant, (2) loss of heat rejection through heat sink, and (3) overcooling due to abnormal cold temperature of seawater. In all kinds of accident scenarios, maximum peak fuel temperatures were well below than the fuel failure criterion, 1600 °C and the GTHTR300 + MED system could be operated continuously and safely. Specially, in the

Dynamic radar cross section measurements of a full-scale aircraft for RCS modelling validation

CSIR Research Space (South Africa)

Van Schalkwyk, Richard F

2017-10-01

Full Text Available In this paper the process followed in generating a high fidelity reference data set for radar cross section (RCS) modelling validation for a full-scale aircraft, is presented. An overview of two dynamic RCS measurement campaigns, involving both...

Gruppemusikterapi med patienter med borderline-personlighedsforstyrrelse i dagbehandlingsregi

Directory of Open Access Journals (Sweden)

Niels Hannibal

2008-05-01

Full Text Available Denne artikel er første redegørelse for de erfaringer, som er gjort med gruppemusikterapi (GMT for patienter med borderline-personlighedsforstyrrelse (BPF i dagbehandlingsregi på Aalborg Psykiatriske Sygehus. Artiklen indeholder både konkrete anvisninger til aktiviteter og interventioner, ligesom den i et teoretisk perspektiv redegør for forskellige processer og reaktioner, der kan iagttages i behandlingen. Artiklen konkluderer, at GMT i sin nuværende form kan bidrage til udvikling af BPF-patienters evne til mentalisering og affektregulering, til opbygning af en gruppefølelse og fremme af interpersonel læring, ligesom GMT kan udvikle alliance til terapi generelt og GMT specifikt.

Bcl-2 expression during the development and degeneration of RCS rat retinae.

Science.gov (United States)

Sharma, R K

2001-12-14

In various hereditary retinal degenerations, including that in Royal College of Surgeons (RCS) rats, the photoreceptors ultimately die by apoptosis. Bcl-2 is one of the genes, which regulates apoptosis and is thought to promote survival of cells. This study has investigated the developmental expression of Bcl-2 in RCS rat, which is a well-studied animal model for hereditary retinal degeneration. An antibody against Bcl-2 was used for its immunohistochemical localization in dystrophic RCS rat retinae from postnatal (PN) days 4, 7, 13, 35, 45, 70, 202 and 14 months. Results were compared with Bcl-2 localization in congenic non-dystrophic rats from PN 4, 7, 13, 44, 202 and 14 months. Bcl-2 immunoreactivity in non-dystrophic retinae was already present in PN 4 retinae in the nerve fiber layer (presumably in the endfeet of immature Müller cells) and in the proximal parts of certain radially aligned neuroepithelial cells/immature Müller cell radial processes. With increasing age the immunoreactivity in relatively more mature Müller cell radial processes spread distally towards the outer retina and between PN 13 and 44 it reached the adult distribution. No cell bodies in the ganglion cell layer were found to be immunoreactive. Expression of Bcl-2 immunoreactivity in dystrophic RCS rat retinae closely resembled that of non-dystrophic retinae. No immunoreactivity was seen in photoreceptors or retinal pigment epithelium in dystrophic or non-dystrophic retinae. In conclusion, Bcl-2 expression is not altered, either in terms of its chronology or the cell type expressing it, during retinal degeneration in RCS rats.

Mellem nyliberalisme og terror - Interview med Chantal Mouffe

DEFF Research Database (Denmark)

Hansen, Allan Dreyer; Sonnichsen, André

2012-01-01

Interview med Chantal Mouffe om Hegemony and Socalist Strategy, modstandere og fjender en ny multipolær verdensorden og demokrati......Interview med Chantal Mouffe om Hegemony and Socalist Strategy, modstandere og fjender en ny multipolær verdensorden og demokrati...

Effektivisering av arbetet med rumsbeskrivningar

OpenAIRE

Enström, Magnus

2016-01-01

För att ta byggbranschen till nästa steg i utvecklingen är BIM det naturliga steget. Iteorin tycks många av lösningarna som medföljer implementationen av BIM varaenkla att förstå och skapa, i praktiken ligger dock de tekniska lösningarna långt ifrånen full implementation i branschen. I arbetet med olika typer av beskrivningar inomett byggprojekt har utvecklingen med hjälp av BIM stått still länge. Då det inte finnsnågot vedertaget sätt att utnyttja en BIM-modells information för att fylla oli...

76 FR 441 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Science.gov (United States)

2011-01-05

... Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R...-622, B4-605R, B4-622R, F4-605R, F4-622R, and C4-605R Variant F airplanes, certificated in any category...

Design Considerations for Proposed Fermilab Integrable RCS

Energy Technology Data Exchange (ETDEWEB)

Eldred, Jeffrey [Fermilab; Valishev, Alexander

2017-03-02

Integrable optics is an innovation in particle accelerator design that provides strong nonlinear focusing while avoiding parametric resonances. One promising application of integrable optics is to overcome the traditional limits on accelerator intensity imposed by betatron tune-spread and collective instabilities. The efficacy of high-intensity integrable accelerators will be undergo comprehensive testing over the next several years at the Fermilab Integrable Optics Test Accelerator (IOTA) and the University of Maryland Electron Ring (UMER). We propose an integrable Rapid-Cycling Synchrotron (iRCS) as a replacement for the Fermilab Booster to achieve multi-MW beam power for the Fermilab high-energy neutrino program. We provide a overview of the machine parameters and discuss an approach to lattice optimization. Integrable optics requires arcs with integer-pi phase advance followed by drifts with matched beta functions. We provide an example integrable lattice with features of a modern RCS - long dispersion-free drifts, low momentum compaction, superperiodicity, chromaticity correction, separate-function magnets, and bounded beta functions.

20 CFR 300.1 - Words and phrases.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Words and phrases. 300.1 Section 300.1 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT DEFINITIONS § 300.1 Words and phrases. For the purposes of the regulations in this part, except where the...

Subretinally transplanted embryonic stem cells rescue photoreceptor cells from degeneration in the RCS rats.

Science.gov (United States)

Schraermeyer, U; Thumann, G; Luther, T; Kociok, N; Armhold, S; Kruttwig, K; Andressen, C; Addicks, K; Bartz-Schmidt, K U

2001-01-01

The Royal College of Surgeons (RCS) rat is an animal model for retinal degeneration such as the age-related macular degeneration. The RCS rat undergoes a progressive retinal degeneration during the early postnatal period. A potential treatment to prevent this retinal degeneration is the transplantation into the subretinal space of cells that would replace functions of the degenerating retinal pigment epithelium (RPE) cells or may form neurotrophic factors. In this study we have investigated the potential of subretinally transplanted embryonic stem cells to prevent the genetically determined photoreceptor cell degeneration in the RCS rat. Embryonic stem cells from the inner cell mass of the mouse blastocyst were allowed to differentiate to neural precursor cells in vitro and were then transplanted into the subretinal space of 20-day-old RCS rats. Transplanted and sham-operated rats were sacrificed 2 months following cell transplantation. The eyes were enucleated and photoreceptor degeneration was quantified by analyzing and determining the thickness of the outer nuclear layer by light and electron microscopy. In the eyes transplanted with embryonic cells up to 8 rows of photoreceptor cell nuclei were observed, whereas in nontreated control eyes the outer nuclear layer had degenerated completely. Transplantation of embryonic stem cells appears to delay photoreceptor cell degeneration in RCS rats.

76 FR 19724 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Science.gov (United States)

2011-04-08

... B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R Variant F Airplanes (Collectively... F4-605R and F4-622R airplanes, and Model A300 C4-605R Variant F airplanes; and Model A310-203, -204...

Alterations in NMDA receptor expression during retinal degeneration in the RCS rat.

Science.gov (United States)

Gründer, T; Kohler, K; Guenther, E

2001-01-01

To determine how a progressive loss of photoreceptor cells and the concomitant loss of glutamatergic input to second-order neurons can affect inner-retinal signaling, glutamate receptor expression was analyzed in the Royal College of Surgeons (RCS) rat, an animal model of retinitis pigmentosa. Immunohistochemistry was performed on retinal sections of RCS rats and congenic controls between postnatal (P) day 3 and the aged adult (up to P350) using specific antibodies against N-methyl-D-aspartate (NMDA) subunits. All NMDA subunits (NR1, NR2A-2D) were expressed in control and dystrophic retinas at all ages, and distinct patterns of labeling were found in horizontal cells, subpopulations of amacrine cells and ganglion cells, as well as in the outer and inner plexiform layer (IPL). NRI immunoreactivity in the inner plexiform layer of adult control retinas was concentrated in two distinct bands, indicating a synaptic localization of NMDA receptors in the OFF and ON signal pathways. In the RCS retina, these bands of NRI immunoreactivity in the IPL were much weaker in animals older than P40. In parallel, NR2B immunoreactivity in the outer plexiform layer (OPL) of RCS rats was always reduced compared to controls and vanished between P40 and P120. The most striking alteration observed in the degenerating retina, however, was a strong expression of NRI immunoreactivity in Müller cell processes in the inner retina which was not observed in control animals and which was present prior to any visible sign of photoreceptor degeneration. The results suggest functional changes in glutamatergic receptor signaling in the dystrophic retina and a possible involvement of Müller cells in early processes of this disease.

THYDE-P2 code: RCS (reactor-coolant system) analysis code

International Nuclear Information System (INIS)

Asahi, Yoshiro; Hirano, Masashi; Sato, Kazuo

1986-12-01

THYDE-P2, being characterized by the new thermal-hydraulic network model, is applicable to analysis of RCS behaviors in response to various disturbances including LB (large break)-LOCA(loss-of-coolant accident). In LB-LOCA analysis, THYDE-P2 is capable of through calculation from its initiation to complete reflooding of the core without an artificial change in the methods and models. The first half of the report is the description of the methods and models for use in the THYDE-P2 code, i.e., (1) the thermal-hydraulic network model, (2) the various RCS components models, (3) the heat sources in fuel, (4) the heat transfer correlations, (5) the mechanical behavior of clad and fuel, and (6) the steady state adjustment. The second half of the report is the user's mannual for the THYDE-P2 code (version SV04L08A) containing items; (1) the program control (2) the input requirements, (3) the execution of THYDE-P2 job, (4) the output specifications and (5) the sample problem to demonstrate capability of the thermal-hydraulic network model, among other things. (author)

Spilleregler i musikterapi med børn

DEFF Research Database (Denmark)

Holck, Ulla

2005-01-01

Artiklen gennemgår udvalgte eksempler på anvendelse af spilleregler i musikterapi med børneklientgrupper. Efter en kort introduktion af Priestleys syn på analytisk musikterapi med børn, præsenteres læseren således for en række caseeksempler fra faglitteraturen, der giver indblik i udformning og a...

Forsøg med 4 centralt belastede betonelementer samt 4 tilhørende betoncylindre

DEFF Research Database (Denmark)

Ellegaard, Peter; Hansen, Lars Pilegaard

Nærværende rapport indeholder beskrivelser og resultater for en række forsøg udført i Laboratoriet for Bærende Konstruktioner, Aalborg Universitet. Prøvelegemerne, som er nærmere beskrevet i kapitel 1, består af 4 betonelementer med en længde på 2600 mm og et tværsnitsareal på 400x120 mm. Element......Nærværende rapport indeholder beskrivelser og resultater for en række forsøg udført i Laboratoriet for Bærende Konstruktioner, Aalborg Universitet. Prøvelegemerne, som er nærmere beskrevet i kapitel 1, består af 4 betonelementer med en længde på 2600 mm og et tværsnitsareal på 400x120 mm....... Elementerne er belastet centralt med tryk, og de er forsynet med transportarmering. Til bestemmelse af betonens brudstyrke og arbejdskurve op til 75% af brudstyrken er der udført forsøg på 4betoncylindre med diameter 100 mm og højde 200 mm. Elementerne og cylinderne er fremstillet af Fårup Betonindustri A...

Mutual Coupling Effects for Radar Cross Section (RCS of a Series-Fed Dipole Antenna Array

Directory of Open Access Journals (Sweden)

H. L. Sneha

2012-01-01

Full Text Available The estimation of RCS of a phased array depends on various parameters, namely, array geometry, operational frequency, feed network, mutual coupling between the antenna elements and so fourth. This paper presents the estimation of RCS of linear dipole array with series-feed network by tracing the signal path from the antenna aperture into the feed network. The effect of mutual coupling exhibited by the dipole antenna is considered for three configurations namely, side by side, collinear, and parallel in echelon. It is shown that the mutual coupling affects the antenna pattern (and hence RCS significantly for larger scan angles. Further it is inferred that the RCS of phased array can be optimized by (i reducing the length of the dipole, (ii termination of the isolation port of the coupler with a suitable load, and (iii using suitable amplitude distribution.

Radar cross-section (RCS) analysis of high frequency surface wave radar targets

OpenAIRE

ÇAKIR, Gonca; SEVGİ, Levent

2010-01-01

Realistic high frequency surface wave radar (HFSWR) targets are investigated numerically in terms of electromagnetic wave -- target interactions. Radar cross sections (RCS) of these targets are simulated via both the finite-difference time-domain (FDTD) method and the Method of Moments (MoM). The virtual RCS prediction tool that was introduced in previous work is used for these investigations. The virtual tool automatically creates the discrete FDTD model of the target under investi...

75 FR 27956 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Science.gov (United States)

2010-05-19

... B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R Variant F Airplanes (Collectively...-203, and B4-203 airplanes; Model A300 B4-601, B4- 603, B4-620, B4-622, B4-605R, B4-622R, F4-605R, F4...

Musikalsk leg med formgivning, timing og vitalitetsformer

DEFF Research Database (Denmark)

Holck, Ulla

2015-01-01

Ifølge de Udviklingsorienterede Social-Pragmatiske Interventionsformer til børn med Autisme Spektrum Forstyrrelse er en legende indfaldsvinkel, hvor man følger barnets lead, den mest effektive til at engagere yngre børn med autisme eller børn med svær autisme i et gensidigt samspil. Artiklen...

TMI-2 RCS activity and solids loading from aggressive defueling techniques

International Nuclear Information System (INIS)

Baston, V.F.; Hofstetter, K.J.

1987-01-01

One of the tasks performed in support of defueling operations has involved mechanical degradation of resolidified material (core crust layer) utilizing the core drilling equipment. Prior to actual drilling operations, an engineering estimate was made for the anticipated increase in radioactivity and particulate loading to the Three Mile Island Unit 2 (TMI-2) reactor coolant system (RCS). Predictions for RCS activity and particulate loading increases were important to evaluate the cleanup requirements for the defueling water cleanup system to minimize both the dose rates for defueling personnel and water turbidity

National trivselsdag med fokus på bevægelse

DEFF Research Database (Denmark)

Holt, Anne-Didde

2016-01-01

breaks”, skriver tre elever. Trivselsdagen gav ligeledes anledning til at dele de gode erfaringer, der indtil nu er udsprunget af ’Trivsel og Bevægelse i Skolen’ - P1 Morgen, P4 Fyn og TV-avisen bragte historier fra dagen på Glamsbjergskolen i Assens, mens P4 Midt og Vest besøgte Haldgård Skole i...... til at fordybe sig i, videreudvikle og vise omverdenen, hvordan der arbejdes med at fremme trivsel gennem bevægelse. Eleverne arbejdede bl.a. med at udvikle og afprøve brain breaks, som er små pauser med bevægelsesaktiviteter, der lægges ind i løbet af den stillesiddende undervisning. Formålet var...... for dem. ”Vi synes brain breaks er vigtige fordi med brain breaks får vi meget mere energi og fordi at man får et bedre forhold til sine klassekammerater, som man måske ikke snakker med så tit. Man kan holde til mere og det er vigtigt at få en pause til at tænke så derfor vil vi gerne have flere brain...

Changes in intrinsic excitability of ganglion cells in degenerated retinas of RCS rats

Directory of Open Access Journals (Sweden)

Yi-Ming Ren

2018-05-01

Full Text Available AIM: To evaluate the intrinsic excitability of retinal ganglion cells (RGCs in degenerated retinas. METHODS: The intrinsic excitability of various morphologically defined RGC types using a combination of patch-clamp recording and the Lucifer yellow tracer in retinal whole-mount preparations harvested from Royal College of Surgeons (RCS rats, a common retinitis pigmentosa (RP model, in a relatively late stage of retinal degeneration (P90 were investigated. Several parameters of RGC morphologies and action potentials (APs were measured and compared to those of non-dystrophic control rats, including dendritic stratification, dendritic field diameter, peak amplitude, half width, resting membrane potential, AP threshold, depolarization to threshold, and firing rates. RESULTS: Compared with non-dystrophic control RGCs, more depolarizations were required to reach the AP threshold in RCS RGCs with low spontaneous spike rates and in RCS OFF cells (especially A2o cells, and RCS RGCs maintained their dendritic morphologies, resting membrane potentials and capabilities to generate APs. CONCLUSION: RGCs are relatively well preserved morphologically and functionally, and some cells are more susceptible to decreased excitability during retinal degeneration. These findings provide valuable considerations for optimizing RP therapeutic strategies.

Forandringslæring med autismediagnoser?

DEFF Research Database (Denmark)

Gustafson, Kari Ingrid; Mørck, Line Lerche

2013-01-01

Artiklen drøfter en række aktuelle spørgsmål omkring læring hos børn og unge med autisme-spektrum-forstyrrelses diagnoser. Der introduceres til en social praksisteoretisk forståelse af forandringslæring, der diskuterer forandring ikke kun i relation til en persons identitet, men også aktuelle og...... potentielle forandringer, når det gælder overskridelse af binær logik i autisme versus normalitet, samt i relation til at overskride individualiserede og dualistiske problem-forståelser af fejl og mangler ved det autistiske barn. Det illustreres, hvordan disse former for dualistisk tænkning er forankret i et...... Rasmus’ ændringer i læring, selvforståelse og tilhørsforhold perspektiveres med andre ASF-diagnostiseredes læring udforsket bl.a. gennem gruppeinterviews i regi af Asperger-foreningen. Artiklen byder således på et alternativ i form af at forstå forandringslæring som overskridende læring, med langt større...

RCS Leak Rate Calculation with High Order Least Squares Method

International Nuclear Information System (INIS)

Lee, Jeong Hun; Kang, Young Kyu; Kim, Yang Ki

2010-01-01

As a part of action items for Application of Leak before Break(LBB), RCS Leak Rate Calculation Program is upgraded in Kori unit 3 and 4. For real time monitoring of operators, periodic calculation is needed and corresponding noise reduction scheme is used. This kind of study was issued in Korea, so there have upgraded and used real time RCS Leak Rate Calculation Program in UCN unit 3 and 4 and YGN unit 1 and 2. For reduction of the noise in signals, Linear Regression Method was used in those programs. Linear Regression Method is powerful method for noise reduction. But the system is not static with some alternative flow paths and this makes mixed trend patterns of input signal values. In this condition, the trend of signal and average of Linear Regression are not entirely same pattern. In this study, high order Least squares Method is used to follow the trend of signal and the order of calculation is rearranged. The result of calculation makes reasonable trend and the procedure is physically consistence

Activation of retinal stem cells in the proliferating marginal region of RCS rats during development of retinitis pigmentosa.

Science.gov (United States)

Jian, Qian; Xu, Haiwei; Xie, Hanping; Tian, Chunyu; Zhao, Tongtao; Yin, ZhengQin

2009-11-06

Retinal stem cells (RSCs) have been demonstrated at the proliferating marginal regions from the pars plana of ciliary body to the ciliary marginal zone (CMZ) in adult lower vertebrates and mammals. Investigations in the lower vertebrates have provided some evidence that RSCs can proliferate following retinal damage; however, the evidence that this occurs in mammals is not clear. In this study, we explored RSCs proliferation potential of adult mammalian in proliferating marginal regions of Royal College of Surgeons (RCS) rats, an animal model for retinitis pigmentosa (RP). The proliferation was evaluated using BrdU labeling, and Chx-10 as markers to discern progenitor cell of CMZ in Long-Evan's and RCS rats at different postnatal day (PND) after eye opening. We found that few Chx-10 and BrdU labeled cells in the proliferating marginal regions of Long-Evan's rats, which significantly increased in RCS rats at PND30 and PND60. Consistent with this, Chx-10/Vimentin double staining cells in the center retina of RCS rats increased significantly at PND30 after eye opening. In addition, mRNA expression of Shh, Ptch1 and Smo was up-regulated in RCS rats at PND60 compared to age-matched Long-Evan's rats, which revealed Shh/ptc pathway involving in the activation of RSCs. These results suggest that RSCs in the mammalian retinal proliferating marginal regions has the potential to regenerate following degeneration.

Location Privacy on DVB-RCS using a “Spatial-Timing” Approach

Directory of Open Access Journals (Sweden)

A. Aggelis

2011-09-01

Full Text Available DVB-RCS synchronization scheme on the Return Channel requires the RCSTs to be programmed with their location coordinates with an accuracy of no more than a few kilometers. RCSTs use this location information in their ranging calculation to the servicing satellite. For certain users this location information disclosure to the network operator can be seen as a serious security event. Recent work of the authors overcame this requirement by cloaking the location of an RCST in such a way (based on "spatial/geometric" symmetries of the network that the respective ranging calculations are not affected. In this work we argue that timing tolerances in the Return Channel synchronization scheme, accepted by the DVB-RCS standard, can be used in combination to the "spatial" method, further enhancing the location privacy of an RCST. Theoretical findings of the proposed "spatial-timing" approach were used to develop a practical method that can be used by workers in the field. Finally this practical method was successfully tested on a real DVB-RCS system.

Akupunktur til patienten med kvalme og opkastning i forbindelse med kemoterapi - er der evidens for dette?

DEFF Research Database (Denmark)

Pedersen, Birgith; Sørensen, Lene Bundgaard; Stricker, Lisbeth

2008-01-01

  Patienter, der får kemoterapi med højemetogene stoffer lider stadig af kvalme og opkastning trods understøttende behandling med moderne antieemtika som 5HT3-antagonister eksempelvis ondansetron. Akupunkturstimulation anvendes for flere lidelser i sundhedsvæsenet og det undersøges om der er evid...

Geograf med GIS som ledetråd

DEFF Research Database (Denmark)

Nielsen, Søren Zebitz

2013-01-01

Fra speciale om kortlægning af luft forurening med NO2 i troposfæren målt fra satellit til PhD studerende med fokus på forståelsen af menneskers bevægelsesmønstre i byer. GIS og geodata er den røde tråd der binder de brede interesser indenfor geografi en sammen for denne forskerlærling.......Fra speciale om kortlægning af luft forurening med NO2 i troposfæren målt fra satellit til PhD studerende med fokus på forståelsen af menneskers bevægelsesmønstre i byer. GIS og geodata er den røde tråd der binder de brede interesser indenfor geografi en sammen for denne forskerlærling....

Dynamic RCS Simulation of a Missile Target Group Based on the High-frequency Asymptotic Method

Directory of Open Access Journals (Sweden)

Zhao Tao

2014-04-01

Full Text Available To simulate dynamic Radar Cross Section (RCS of missile target group, an efficient RCS prediction approach is proposed based on the high-frequency asymptotic theory. The minimal energy trajectory and coordinate transformation is used to get trajectories of the missile, decoys and roll booster, and establish the dynamic scene for the separate procedure of the target group, and the dynamic RCS including specular reflection, edge diffraction and multi-reflection from the target group are obtained by Physical Optics (PO, Equivalent Edge Currents (EEC and Shooting-and-Bouncing Ray (SBR methods. Compared with the dynamic RCS result with the common interpolation method, the proposed method is consistent with the common method when the targets in the scene are far away from each other and each target is not sheltered by others in the incident direction. When the target group is densely distributed and the shelter effect can not be neglected, the interpolation method is extremely difficult to realize, whereas the proposed method is successful.

Hvad skal vi med Trump-satire?

DEFF Research Database (Denmark)

Møller, Mette

2017-01-01

Trump-satire er et stort hit, og særligt en lang række satiriske videohilsner til Trump fra lande verden over får folk til at trække på smilebåndet. Men hvorfor er det så sjovt at gøre grin med Trump, og hvad kan vi bruge den politiske humor til?......Trump-satire er et stort hit, og særligt en lang række satiriske videohilsner til Trump fra lande verden over får folk til at trække på smilebåndet. Men hvorfor er det så sjovt at gøre grin med Trump, og hvad kan vi bruge den politiske humor til?...

Kulturbankeprojekt med udlægning af blåmuslinger produceret på langline

DEFF Research Database (Denmark)

Dolmer, Per; Christensen, Helle Torp; Christoffersen, Mads Ole

Farm systemer, men pga isskader på anlæg var dette ikke muligt. I maj 2011 blev 75 tons kompensationsopdrættede muslinger fra Skive Fjord udlagt i et 300x100 m stort område på 10-11 meters vanddybde i en tæthed på 2,5 kg m-2. I forbindelse med afhøstning af muslingerne i Skive Fjord, transport til Horsens Fjord...... hydrodynamisk model og en økologisk model. Til modelarbejdet anvendes data fra 2011 og første halvår 2012, samt data for muslingers tilvækst, som er indsamlet under projektet. På baggrund af modelanalyser anbefales det at udlægningstætheden af muslinger i området ikke overskriver 400 individer m-2. Kortlægning...... på 4-5 meters dybde. Der er gennemført 14 punktdyk med dykkerobservationer og billedoptagelse, og der er gennemført en side scan kortlægning af området. Der er ikke observeret ålegræs i området. I forbindelse med projektet er projektets resultater formidlet til Fødevareministeriet og Miljøministeriet...

Mindfulness som smertehåndteringsredskab for kvinder med endometriose

DEFF Research Database (Denmark)

Jensen, Mette Kold; Vedsted-Hansen, Hanne; Hansen, Tia G. B.

2011-01-01

Endometriose er en kronisk underlivssygdom med smerter og en række afledte problemer, som ikke nødvendigvis kan behandles med lægelige tiltag. Artiklen argumenterer for, at en mindfulness-baseret tilgang med fokus på smertehåndtering kan anvendes til denne klientgruppe. I vestlig terapeutisk...... sammenhæng kan mindfulness karakteriseres som nærvær, observation og beskrivelse af sansninger uden vurdering eller reaktion. Mindfulness-træning har effekt mod andre typer stress og kroniske smerter, og artiklen opridser et koncept til anvendelse ved endometriose. Konceptet belyses med en case, hvor...

Fang CO2 med Aminosyrer

DEFF Research Database (Denmark)

Lerche, Benedicte Mai

2010-01-01

Med såkaldte “carbon capture-teknikker” er det muligt at rense røgen fra kulfyrede kraftværker, således at den er næsten helt fri for drivhusgassen CO2. Kunsten er at gøre processen tilstrækkeligt billig. Et lovende fangstredskab i denne proces er aminosyrer.......Med såkaldte “carbon capture-teknikker” er det muligt at rense røgen fra kulfyrede kraftværker, således at den er næsten helt fri for drivhusgassen CO2. Kunsten er at gøre processen tilstrækkeligt billig. Et lovende fangstredskab i denne proces er aminosyrer....

Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk.

Science.gov (United States)

Vollrath, D; Feng, W; Duncan, J L; Yasumura, D; D'Cruz, P M; Chappelow, A; Matthes, M T; Kay, M A; LaVail, M M

2001-10-23

The Royal College of Surgeons (RCS) rat is a widely studied animal model of retinal degeneration in which the inability of the retinal pigment epithelium (RPE) to phagocytize shed photoreceptor outer segments leads to a progressive loss of rod and cone photoreceptors. We recently used positional cloning to demonstrate that the gene Mertk likely corresponds to the retinal dystrophy (rdy) locus of the RCS rat. In the present study, we sought to determine whether gene transfer of Mertk to a RCS rat retina would result in correction of the RPE phagocytosis defect and preservation of photoreceptors. We used subretinal injection of a recombinant replication-deficient adenovirus encoding rat Mertk to deliver the gene to the eyes of young RCS rats. Electrophysiological assessment of animals 30 days after injection revealed an increased sensitivity of treated eyes to low-intensity light. Histologic and ultrastructural assessment demonstrated substantial sparing of photoreceptors, preservation of outer segment structure, and correction of the RPE phagocytosis defect in areas surrounding the injection site. Our results provide definitive evidence that mutation of Mertk underlies the RCS retinal dystrophy phenotype, and that the phenotype can be corrected by treatment of juvenile animals. To our knowledge, this is the first demonstration of complementation of both a functional cellular defect (phagocytosis) and a photoreceptor degeneration by gene transfer to the RPE. These results, together with the recent discovery of MERTK mutations in individuals with retinitis pigmentosa, emphasize the importance of the RCS rat as a model for gene therapy of diseases that arise from RPE dysfunction.

Metal radomes for reduced RCS performance

Science.gov (United States)

Wahid, M.; Morris, S. B.

A frequency selective surface (FSS) comprising a square grid and a hexagonal array of disks is proposed as a means of reducing the Radar Cross Section (RCS) of a radar bay over a wide (2 GHz to 14.6 GHz) frequency bandwidth. Results are presented in terms of transmission loss for an 'A'-type sandwich radome consisting of two FSS layers for normal and non-normal incidence. A single FSS layer on a GRP flat panel is also considered. Good agreement is found between the predicted and measured results. The proposed FSS shows good performance and is relatively insensitive to angle of incidence between 3.8 GHz and 10.1 GHz. Predicted Insertion Phase Delay (IPD) and cross-polar performances are also given. Parametric studies have indicated the versatility of the proposed structure.

VXIbus-based signal generator for resonant power supply system of the 3 GeV RCS

Energy Technology Data Exchange (ETDEWEB)

Zhang, Fengqing; Watanabe, Yasuhiro; Koseki, Shoichiro; Tani, Norio [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Adachi, Toshikazu; Someya, Hirohiko [High Energy Accelerator Reseach Organization, Tsukuba, Ibaraki (Japan)

2002-03-01

The 3 GeV Proton RCS of the JAERI-KEK Joint Project is a 25 Hz separate-function rapid cycling synchrotron under design. Bending magnets (BM) and quadrupole magnets (QM) are excited separately. The 3 GeV RCS requests above 10 families of magnets excited independently, far beyond 3 families in practical RCS's. Difficulty of field tracking between BM and QM is significantly increased. Magnet strings are grouped into resonant networks and excited resonantly with power supplies driven by a waveform pattern, typically a DC-biased sinusoidal signal. To achieve a close tracking between many families, the driving signal of each power supply should be adjusted in phase and amplitude flexibly and dynamically. This report proposes a signal generator based on VXIbus. The VXIbus, an extension of VMEbus (VME eXtensions for Instrument), provides an open architecture with shared process bus and timing. The VXIbus-based signal generator facilitates the timing synchronization and is easy to extend to many channels needed by the 3 GeV RCS. Experimental results of the signal generator are reported. (author)

R-HPDC of magnesium alloys

CSIR Research Space (South Africa)

Curle, UA

2013-01-01

Full Text Available Flexibility of the Council for Scientific and Industrial Research’s Rheocasting System (CSIR-RCS) and its rheo-high pressure die casting (R-HPDC) technology is again demonstrated, as with aluminium alloys, by processing and shape casting of three...

Social indsats til borgere med erfaring fra salg af sex

DEFF Research Database (Denmark)

Mehlsen, Line; Amilon, Anna; Henriksen, Theresa Dyrvig

2017-01-01

Formålet med denne guide er at give endnu flere kommuner inspiration og vejledning til, hvordan man kan implementere og arbejde med CTI-forløb over for borgere med prostitutionserfaring. Manglende viden om borgere med prostitutionserfaringer gør det svært for kommunerne at hjælpe borgerne med de ...

Specifik mutation med nålestiksoperation

DEFF Research Database (Denmark)

Holme, Inger; Wendt, Toni; Brinch-Pedersen, Henrik

2014-01-01

Mutanter af byg er vigtige i forskningen og benyttes også, når der forædles nye sorter til dyrkning. Hidtil har det kun været muligt at inducere mutationer tilfældige steder i genomet. Med helt ny teknologi benyttes proteiner med betegnelsen TALENs til at inducere mutationer i helt specifikke...

Parallel Computation of RCS of Electrically Large Platform with Coatings Modeled with NURBS Surfaces

Directory of Open Access Journals (Sweden)

Ying Yan

2012-01-01

Full Text Available The significance of Radar Cross Section (RCS in the military applications makes its prediction an important problem. This paper uses large-scale parallel Physical Optics (PO to realize the fast computation of RCS to electrically large targets, which are modeled by Non-Uniform Rational B-Spline (NURBS surfaces and coated with dielectric materials. Some numerical examples are presented to validate this paper’s method. In addition, 1024 CPUs are used in Shanghai Supercomputer Center (SSC to perform the simulation of a model with the maximum electrical size 1966.7 λ for the first time in China. From which, it can be found that this paper’s method can greatly speed the calculation and is capable of solving the real-life problem of RCS prediction.

13 CFR 300.1 - Introduction and mission.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Introduction and mission. 300.1 Section 300.1 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE... innovation and competitiveness, preparing American regions for growth and success in the worldwide economy...

MANUAL FOR PROCESORIENTERET MUSIKTERAPI MED PERSONER MED BPD.

Directory of Open Access Journals (Sweden)

Niels Hannibal

2010-12-01

Full Text Available Denne artikel introducerer et musikterapeutisk behandlingskoncept kaldet: Procesorienteret Musikterapi (PROM. PROM er et forsøg på at formulere en principiel ramme for musikterapi i psykiatrien, som dels tager udgangspunkt i 17 års klinisk erfaring, dels stiler mod at være ”best practice”. PROM indeholder beskrivelser af manualens unikke, essentielle men ikke unikke, acceptable og ikke acceptable dele. Den unikke del af PROM skal kunne implementeres til alle målgrupper, mens de øvrige dele af manualen rettes til i forhold til en specifik målgruppe. Denne udgave af PROM er specifikt rettet i mod musikterapi for patienter med personlighedsforstyrrelser. Manualen indgår også som en del af et pilotprojekt, der har til formål at udvikle en protokol for et internationalt RCT projekt med samme målgruppe

Når to mennesker møtes: Hvordan kan sykepleier møte pasienter med selvskadende atferd

OpenAIRE

Eikrem, Mats Ulstein

2017-01-01

Høgskulen på Vestlandet Institutt for sykepleie Avdeling for helsefag Tittel: Når to mennesker møtes Bakgrunn for val av tema: Bakgrunnen for tema er mine egne erfaringer innenfor legevakts arbeid, og de observasjonene jeg har tilnærmet meg der. Noe som har ført til at jeg opplever at sykepleiere ikke skaper nok rom for pasienter med selvskadende atferd. Jeg ønsker derfor å lære mer om hvordan man bør møte denne pasientgruppen på en god måte. Problemstilling: Hvordan kan syk...

At lede med latter

DEFF Research Database (Denmark)

Møller, Mette

2014-01-01

"Det sagde hun også i går!" Platte vitser, der lægger op til den karakteristiske 'bodom-tchi'-trommelyd, behøver ikke være lederens eneste forsøg på at udvise humoristisk sans på talerstolen. For humor kan være meget andet og gøre meget mere for lederen end at score billige point med en spontan s...... spøg. Humor kan skabe klarhed over en pointe, skabe lederens image og skabe sammenhold i organisationen. Uden trommelyd, men med mange andre effekter i spil....

Experimental Results and Numerical Simulation of the Target RCS using Gaussian Beam Summation Method

Directory of Open Access Journals (Sweden)

Ghanmi Helmi

2018-05-01

Full Text Available This paper presents a numerical and experimental study of Radar Cross Section (RCS of radar targets using Gaussian Beam Summation (GBS method. The purpose GBS method has several advantages over ray method, mainly on the caustic problem. To evaluate the performance of the chosen method, we started the analysis of the RCS using Gaussian Beam Summation (GBS and Gaussian Beam Launching (GBL, the asymptotic models Physical Optic (PO, Geometrical Theory of Diffraction (GTD and the rigorous Method of Moment (MoM. Then, we showed the experimental validation of the numerical results using experimental measurements which have been executed in the anechoic chamber of Lab-STICC at ENSTA Bretagne. The numerical and experimental results of the RCS are studied and given as a function of various parameters: polarization type, target size, Gaussian beams number and Gaussian beams width.

Personer med handicap

DEFF Research Database (Denmark)

Larsen, Brian; Jonassen, Anders Bruun; Høgelund, Jan

Regeringens Arbejdsmarkedskommission kommmer medio 2009 med forslag til, hvordan den samlede arbejdsindsats varigt kan øges gennem reformer på arbejdsmarkedet. En måde det kan ske på, er ved at begrænse antallet af personer, der står uden for arbejdsmarkedet som følge af helbredsproblemer. Rappor...

Hvad SKER der med drikkevandet i USA?

DEFF Research Database (Denmark)

Ramsay, Loren Mark

2017-01-01

Forskellige lande har forskellige traditioner indenfor drikkevandsbehandling. Denne beretning fra ”Water Quality Technology Conference” i USA er set med en særlig vinkel, da forfatteren er amerikansk statsborger, men har arbejdet i den danske vandbranche i mere end 25 år.......Forskellige lande har forskellige traditioner indenfor drikkevandsbehandling. Denne beretning fra ”Water Quality Technology Conference” i USA er set med en særlig vinkel, da forfatteren er amerikansk statsborger, men har arbejdet i den danske vandbranche i mere end 25 år....

Sociale indsatser til mennesker med ADHD

DEFF Research Database (Denmark)

Bengtsson, Steen; Alim, Winnie; Holmskov, Henriette

Igennem de seneste år har flere og flere fået stillet diagnosen ADHD, som er en adfærdsmæssig forstyrrelse. Mennesker med ADHD har meget forskelligt støttebehov, og rapportens formål er at skabe overblik over de eksisterende sociale indsatser og tilbud til børn, unge og voksne med ADHD. Langt de...... ansvar for sociale end for terapeutiske tilbud i forhold til gruppen med ADHD. Mange voksne med ADHD beskriver, at det kræver mange ressourcer at få den fornødne støtte fra kommunen, mens forældre til børn med ADHD oplever det som nemmere at få adgang til de rette støttetilbud. Men begge grupper møder...... mange udfordringer som fx manglende koordinering og hyppige sagsbehandlerskift. Rapporten er udarbejdet i tilknytning til Servicestyrelsens projekt ’Ny og forstærket indsats til børn, unge og voksne med ADHD’ og er finansieret af Socialministeriet....

KOMMUNIKATIVT LEDARSKAP ett ledarskap för moderna organisationer : Kvalitativ studie med ansats att definiera begreppet

OpenAIRE

Axäll, Jenny

2004-01-01

AbstractTitle: Communicative leadership – a leadership for modern organizationsQualitative research attempting to define the concept.(Kommunikativt ledarskap – ett ledarskap för moderna organisationerKvalitativ studie med ansats att definiera begreppet.)Author: Jenny AxällAim: The aim of this essay is to try to find the essence of and a definition of the communicative leadership. Questions asked are: How can communicative leadership be described? How can it be practiced? What does it demand o...

ESTIMATION OF WIDE BAND RADAR CROSS SECTION (RCS OF REGULAR SHAPED OBJECTS USING METHOD OF MOMENTS (MOM

Directory of Open Access Journals (Sweden)

M. Madheswaran

2012-06-01

Full Text Available Modern fighter aircrafts, ships, missiles etc need to be very low Radar Cross Section (RCS designs, to avoid detection by hostile radars. Hence accurate prediction of RCS of complex objects like aircrafts is essential to meet this requirement. A simple and efficient numerical procedure for treating problems of wide band RCS prediction Perfect Electric Conductor (PEC objects is developed using Method of Moment (MoM. Implementation of MoM for prediction of RCS involves solving Electric Field Integral Equation (EFIE for electric current using the vector and scalar potential solutions, which satisfy the boundary condition that the tangential electric field at the boundary of the PEC body is zero. For numerical purposes, the objects are modeled using planar triangular surfaces patches. Set of special sub-domain type basis functions are defined on pairs of adjacent triangular patches. These basis functions yield a current representation free of line or point charges at sub-domain boundaries. Once the current distribution is obtained, dipole model is used to find Scattering field in free space. RCS can be calculated from the scattered and incident fields. Numerical results for a square plate, a cube, and a sphere are presented over a bandwidth.

Seabrook simulator model upgrade: Implementation and validation of two-phase, nonequilibrium RCS and steam generator models

International Nuclear Information System (INIS)

Kao, S.

1990-01-01

A number of deficiencies in the original RCS and steam generator models on the Seabrook simulator were found to give unrealistic results under some off-normal and accident conditions. These deficiencies are attributed to the simplistic assumptions used in the original models, such as the homogeneous, equilibrium equations used in the pressurizer and steam generator models, and the single-phase flow model used in the RCS thermal-hydraulic model. To improve the fidelity of the simulator, efforts have been made to upgrade the RCS and steam generator models to include two-phase, nonequilibrium features. In the new RCS model, the following major assumptions are used to derive the finite difference form of the conservation equations: a donor-cell differencing scheme is adopted to allow flow reversal; a single pressure is used to evaluate properties; a single mass flow rate is assumed in each loop; enthalpy is assumed to vary linearly within each control volume; a homogeneous flow is assumed under two-phase conditions. The pressurizer is divided into a vapor region and a liquid region, each of which is represented by a set of mass and energy conservation equations. Interfacial mass and energy exchange mechanisms (condensation and flashing), thermal interactions between the vessel and fluids, and thermal nonequilibrium between the phases are included in the pressurizer model. The steam generator is divided into the vapor dome, riser, and downcomer regions. The assumptions applied are similar to those of the RCS and pressurizer models. A momentum model is incorporated to calculate the recirculation flow and simulate the downcomer level shrink/swell phenomenon. The new RCS and steam generator models are validated by comparing the simulator calculations against sister plant data and FSAR vendor analysis. The results show the new models give realistic and reliable calculations under off-normal and accident conditions

Verification of the CADRCS RCS tool for NCTR work

CSIR Research Space (South Africa)

Botha, L

2007-03-01

Full Text Available This paper looks at the suitability of using the CADRCS RCS prediction tool for research into a class of NCTR work where the radar will give a high resolution output of the target, either a High Range Resolution (HRR) plot or Inverse Synthetic...

Sjuksköterskors upplevelse vid vård av patienter med substansbrukssyndrom

OpenAIRE

Hanna, Johansson; Frida, Zetterman

2016-01-01

Bakgrund Tidigare forskning visar att sjuksköterskor har förutfattade meningar om patienter med en stigmatiserande diagnos. Sjuksköterskor stigmatiserar och har negativa attityder som påverkar deras vård av dessa patienter. Individer med substansbrukssyndrom är en grupp som är särskilt utsatt för stigmatisering i samhället. Dessa individer påträffas inom samtliga specialiteter inom vården. Denna studie fokuserar därför på sjuksköterskors upplevelse av patienter med substansbrukssyndrom. Syfte...

Att drabbas av cancer i tonåren : En kvantitativ studie om hälsorelaterad livskvalitet två till fyra år efter diagnos

OpenAIRE

Hiding, Markus; Lavemark, Niklas

2010-01-01

Syfte Studiens syfte var att undersöka: självskattad hälsorelaterad livskvalitet hos tonåringar som drabbats av cancer två år (T5), tre år (T6) och fyra år (T7) efter diagnos, samt att jämföra deras skattningar med en referensgrupp randomiserad från befolkningen.   Metod Tonåringarna med cancer besvarade SF-36 2 år (N=38), 3 år (N=42) samt 4 år (N=39) efter diagnos. En referensgrupp (N=300) randomiserad av Statistiska centralbyrån (SCB) besvarade samma formulär vid ett tillfälle. Samtlig data...

Implementering af ny standard for forebyggelse af delir i forhold til ældre svagelige patienter > 65 år med hoftefraktur

DEFF Research Database (Denmark)

Bagger, Bettan; Rehder, Bente; Pedersen, Niels

2013-01-01

Baggrund: Pro-hip er et inter-regionalt projekt www.prohip.eu der blandt andet har til formål at evidensbasere den rehabiliterende sygepleje til hoftepatienten i forhold til indsatsområderne; ernæring, urinretention/UVI, delir og tryksår. Delirium er et hyppigt forekommende problem blandt patienter...... standard. Intentionen er således at udvikle en evidensbaseret standard eller instruks, der har til formål at opspore tidlige symptomer på konfusion og dermed forebygge udviklingen af deliriøs tilstand hos patienten med hoftefraktur. Metode: Der er udarbejdet et systematisk review med henblik på...

Hvad spillede de egentlig på P3 i januar 1963? 50 år med P3

DEFF Research Database (Denmark)

Smith-Sivertsen, Henrik

2015-01-01

ungdomsmusik, før P3 kom til, bl.a. med Jørn Hjorting som vært, og Jørgen de Mylius var langtfra den eneste af de nye P3-værter, der slog et ekstra slag for den ny musik. Smith-Sivertsen viser, at Pedro Biker og Hans Jørgen Skov bidrog i lige så høj grad til udbredelsen af fx The Beatles....

Med sjefen på Facebook: En studie av ledere som er "venner" med sine ansatte

OpenAIRE

Jensen, Anita

2014-01-01

MR690 Masteroppgave i organisasjon og ledelse - utdanningsledelse Formålet med studien er å belyse hvordan aktiv bruk av sosiale medier, i dette tilfellet Facebook, påvirker relasjoner mellom mennesker. Hva skjer når en tar i bruk en websjanger som i utgangspunktet er umiddelbar og uformell, til jobbrelatert og mer formell kommunikasjon? Er det sjangeren eller relasjonen som endres? Søkelyset rettes mot ledere som er “venner” med sine medarbeidere, og problemstillingen er...

Arbetet med arbetsgivarvarumärkets attraktivitet : En kvalitativ intervjustudie i tre företag om hur arbetet med "Employer branding" ser ut och implementeras i företag.

OpenAIRE

Drugge, Marie; Bernelind, Diana

2013-01-01

Arbetet med att stärka ett arbetsgivarvarumärkes attraktivitet, både internt och externt, det alltmer välbekanta begreppet “Employer branding”, är ett vanligt förekommande koncept i dagens organisationer. Syftet med studien är att försöka ta reda på vad fenomenet “Employer branding” är och hur organisationer kan bedriva arbetet med att göra sitt arbetsgivarvarumärket attraktiv på den svenska arbetsmarknaden. Tieto, COWI och Klarna AB är de företag som deltar i studien. Begreppen legitimitet o...

MED1 independent activation of endogenous target genes by PPARα

DEFF Research Database (Denmark)

Grøntved, Lars; Bugge, Anne K.; Roeder, Robert G.

The mediator complex serves as a transcriptional co-activator complex by acting as a bridge between promoter-bound transcription factors and the preinitiation complex. Genetic and biochemical studies indicate that nuclear receptors recruit the mediator complex through direct interaction with the ......The mediator complex serves as a transcriptional co-activator complex by acting as a bridge between promoter-bound transcription factors and the preinitiation complex. Genetic and biochemical studies indicate that nuclear receptors recruit the mediator complex through direct interaction...... derived from TRAP220 KO mice. Interestingly, rescue experiments in confluent TRAP220 KO MEFs with different versions of MED1 indicate that the LXXLL motif is not necessary for PPARgamma mediated gene activation (Ge et al, MCB published online ahead of print 2007). By analogy, we show here that MED1...... is dispensable for PPARalpha transcriptional activity in proliferating but is necessary in confluent AML-12 cells and TRAP220 KO MEFs. Collectively this indicates that the PPARs might have adopted an alternative mediator recruitment mechanism that is dispensable of direct interaction with MED1 on endogenous...

Poetisk sortsyn med lys for enden

DEFF Research Database (Denmark)

Larsen, Peter Stein

2015-01-01

Ursula Andkjær Olsens digtsamling " Udgående fartøj" indledes med den følgende prægnante passage, der kan læses i sin helhed som " ugens digt" her på siden: " jeg har brugt tid på at tyde/ sprede dumpe fornemmelser / fra mit fjerne indre (...)......Ursula Andkjær Olsens digtsamling " Udgående fartøj" indledes med den følgende prægnante passage, der kan læses i sin helhed som " ugens digt" her på siden: " jeg har brugt tid på at tyde/ sprede dumpe fornemmelser / fra mit fjerne indre (...)...

Notat om arbejdet med innovation i Randers Kommune

DEFF Research Database (Denmark)

Hansen, Morten Balle; Agger Nielsen, Jeppe

2012-01-01

for innovation i Randers Kommune, herunder hvordan politikerne inddrages i innovationsprocessen, 5) Hvor tæt skal økonomi og innovationsdagsorden knyttes? 6) Hvordan er innovationsdagsordenen relateret til en overordnet strategi for Randers Kommune? og 7) selve organiseringen af innovationsprocessen. Notatet...... hovedpunkter er; 1) udarbejdelse af de gode innovationsspørgsmål, 2) dobbeltudfordringen med på den ene side at sikre daglig drift og på den anden side at arbejde innovativt, 3) top-down versus bottom-up processer, dvs. hvor meget skal innovationsprocesserne designes og styres? 4) den særlige kontekst......Dette notat udgør en erfaringsopsamling fra innovationsdag i Randers Kommune, d. 13. november 2012. Notatet fremhæver hovedpointerne fra interne og eksterne oplægsholdere og udpeger en række fokuspunkter/problemstillinger for arbejdet med innovation i Randers Kommune. De syv identificerede...

Grønnere skibsfart med modstandsdygtige motorer

DEFF Research Database (Denmark)

Lassen, Lisbeth

2015-01-01

Udledningen af forurening fra skibsmotorer skal sænkes kraftigt i de kommende år, og derfor står den maritime industri overfor helt nye krav til blandt andet hvilke brændstoffer, man kan bruge. På grund af de nye regler, der begrænser skibenes energiforbrug, er man også begyndt at sejle med nedsa...... foregår i samarbejde med DTU Kemiteknik og MAN Diesel & Turbo....... hastighed. Både de nye brændstoftyper og den nedsatte hastighed giver problemer for skibsmotorerne, problemer som projektet SULCOR, Sulfuric Acid corrosion in Large Marine Diesel Engines, netop har modtaget 16 millioner kr. fra Innovationsfonden til at begynde at løse. Projektet ledes af DTU Mekanik og...

Endostatin (EntreMed).

Science.gov (United States)

Grosios, K

2000-07-01

EntreMed has licensed the worldwide rights to the angiogenesis inhibitor Endostatin, a 20 kDa C-terminal fragment of collagen XVIII, from the Children's Hospital of Boston, a teaching affiliate of Harvard Medical School. It is being developed as a potential cancer treatment and may also be useful in certain types of blindness and arthritis [227427]. EntreMed filed an IND for Endostatin in June 1999 [334125] and as of September 1999, phase I trials were underway [341462]. As of April 2000, the company had initiated plans for testing low doses of Endostatin in cancer patients using continuous infusion and sc administration in a further phase I study to be conducted in Europe [361594]. A phase I trial of Endostatin which will evaluate the safety and efficacy of Endostatin at a range of doses in no more than 100 cancer patients has been initiated. The trial will take place at the University of Texas MD Anderson Medical Center and the University of Wisconsin Cancer Center in Madison. The National Cancer Center will be sponsoring the trial, which is expected to be completed in late 2000. As of March 2000, there had been no serious adverse events attributable to Endostatin administration. The first report from this trial is expected in autumn 2000 [341462], [366312]. The mechanism of action for Endostatin remains unclear, although reports from the 91st AACR Meeting in April 2000 showed that recombinant human endostatin bound to a number of tropomyosin cDNAs in a library screen [362039]. In preclinical studies, repeated administration of Endostatin consistently shrank primary tumors and did not produce any drug resistance. In mice, a variety of tumors which had progressed to 1 to 2% of total body weight, regressed to microscopic, dormant lesions following Endostatin treatment [231418], [231470], [270673]. Types of cancers which respond to Endostatin include lung, skin, vascular and fibrosarcomas. Toxicology studies in cynomolgus monkeys showed that bolus injections of

Resolution of issues related to alternative RCS injection in the absence of containment sump recirculation

International Nuclear Information System (INIS)

Charles L Kling; Stephen S Barshay; Mathew C Jacob; Michael J Friedman

2005-01-01

evaluations were performed to determine (1) the minimum refill water boron concentration necessary to ensure core sub-criticality, (2) minimum flowrate required to both refill the RWST (to maintain the tank as a source of cooling water) and remove heat from the core, and (3) whether neutralization of the reinjected boric acid is necessary to maintain the pH of the sump fluid greater than or equal to 7.0 in order to prevent re-volatilization of iodines in the fluid. Based on these evaluations a minimum RWST boron concentration of at least 965 ppm is required for the FCS plant. Assuming a minimum time to sump blockage of 30 minutes from the initiation of the LOCA, the required SI flow to the RCS should be at least 215 gpm total SI pump flow to account for. (authors)

Classical and modern power spectrum estimation for tune measurement in CSNS RCS

International Nuclear Information System (INIS)

Yang Xiaoyu; Xu Taoguang; Fu Shinian; Zeng Lei; Bian Xiaojuan

2013-01-01

Precise measurement of betatron tune is required for good operating condition of CSNS RCS. The fractional part of betatron tune is important and it can be measured by analyzing the signals of beam position from the appointed BPM. Usually these signals are contaminated during the acquisition process, therefore several power spectrum methods are used to improve the frequency resolution. In this article classical and modern power spectrum methods are used. In order to compare their performance, the results of simulation data and IQT data from J-PARC RCS are discussed. It is shown that modern power spectrum estimation has better performance than the classical ones, though the calculation is more complex. (authors)

Die EBM-Datenbank DynaMed für PocketPC und Palm

Directory of Open Access Journals (Sweden)

Dollfuß, Helmut

2007-09-01

Full Text Available DynaMed is a database for Evidence Based Medicine. Licencee can download a stand-alone version of this database onto their Personal Digital Assistant (PDA. Contents and aims of DynaMed will be introduced. Main features of the PDA-version will be presented and illustrated with screenshots.

Tur-samspil i musikterapi med børn med svære kommunikationsvanskeligheder

DEFF Research Database (Denmark)

Holck, Ulla

2006-01-01

Tur-samspil udgør en vigtig grundsten i den tidlige sociale og kommunikative udvikling, og optræder ofte i musikterapeutiske samspil med kommunikationssvage børn. Artiklen præsenterer relevante begreber fra faglitteraturen om tur-samspil i voksendialoger (de såkaldte Konversationsanalyser), som k...

Effects of low-frequency repetitive transcranial magnetic stimulation on event-related potential P300

Science.gov (United States)

Torii, Tetsuya; Sato, Aya; Iwahashi, Masakuni; Iramina, Keiji

2012-04-01

The present study analyzed the effects of repetitive transcranial magnetic stimulation (rTMS) on brain activity. P300 latency of event-related potential (ERP) was used to evaluate the effects of low-frequency and short-term rTMS by stimulating the supramarginal gyrus (SMG), which is considered to be the related area of P300 origin. In addition, the prolonged stimulation effects on P300 latency were analyzed after applying rTMS. A figure-eight coil was used to stimulate left-right SMG, and intensity of magnetic stimulation was 80% of motor threshold. A total of 100 magnetic pulses were applied for rTMS. The effects of stimulus frequency at 0.5 or 1 Hz were determined. Following rTMS, an odd-ball task was performed and P300 latency of ERP was measured. The odd-ball task was performed at 5, 10, and 15 min post-rTMS. ERP was measured prior to magnetic stimulation as a control. Electroencephalograph (EEG) was measured at Fz, Cz, and Pz that were indicated by the international 10-20 electrode system. Results demonstrated that different effects on P300 latency occurred between 0.5-1 Hz rTMS. With 1 Hz low-frequency magnetic stimulation to the left SMG, P300 latency decreased. Compared to the control, the latency time difference was approximately 15 ms at Cz. This decrease continued for approximately 10 min post-rTMS. In contrast, 0.5 Hz rTMS resulted in delayed P300 latency. Compared to the control, the latency time difference was approximately 20 ms at Fz, and this delayed effect continued for approximately 15 min post-rTMS. Results demonstrated that P300 latency varied according to rTMS frequency. Furthermore, the duration of the effect was not similar for stimulus frequency of low-frequency rTMS.

En definitionssandhed med modifikationer

DEFF Research Database (Denmark)

Holtermann, Jakob v. H.; Olsen, Henrik Palmer

2013-01-01

Denne artikel indgår i den debat om retskildebegrebet, der tidligere har været rejst af Jens Ravnkilde. Forfatterne påviser flere svagheder i Ravnkildes argumentation, herunder at han ignorerer hele den internationale diskussion på området, samtidig med at han baserer sit eget angiveligt nyudvikl...

Med H.C. Andersen i Portugal år 1866

DEFF Research Database (Denmark)

Skousbøll, Karin

2004-01-01

ankomst med diligence fra Spanien ind over fastlandet til Lissabon, men også rundt i byen, i omegnen og til havnebyen Setubal. Det indsamlede billedstof som underbygger teksten er dels historisk stof indhentet fra Det kg. Bibliotek o.a. kilder og dels fremskaffet fra Portugals arkiver og de respektive...

Constitutively reduced sensory capacity promotes better recovery after spinal cord-injury (SCI) in blind rats of the dystrophic RCS strain.

Science.gov (United States)

Rink, Svenja; Bendella, Habib; Alsolivany, Kurdin; Meyer, Carolin; Woehler, Aliona; Jansen, Ramona; Isik, Zeynep; Stein, Gregor; Wennmachers, Sina; Nakamura, Makoto; Angelov, Doychin N

2018-01-01

We compared functional, electrophysiological and morphological parameters after SCI in two groups of rats Sprague Dawley (SD) rats with normal vision and blind rats from a SD-substrain "Royal College of Surgeons" (SD/RCS) who lose their photoreceptor cells after birth due to a genetic defect in the retinal pigment epithelium. For these animals skin-, intramuscular-, and tendon receptors are major available means to resolve spatial information. The purpose of this study was to check whether increased sensitivity in SD/RCS rats would promote an improved recovery after SCI. All rats were subjected to severe compression of the spinal cord at vertebra Th8, spinal cord segment Th10. Recovery of locomotion was analyzed at 1, 3, 6, 9, and 12 weeks after SCI using video recordings of beam walking and inclined ladder climbing. Five functional parameters were studied: foot-stepping angle (FSA), rump-height index (RHI) estimating paw placement and body weight support, respectively, number of correct ladder steps (CLS) assessing skilled hindlimb movements, the BBB-locomotor score and an established urinary bladder score (BS). Sensitivity tests were followed by electrophysiological measurement of M- and H-wave amplitudes from contractions of the plantar musculature after stimulation of the tibial nerve. The closing morphological measurements included lesion volume and expression of astro- and microglia below the lesion. Numerical assessments of BBB, FSA, BS, lesion volume and GFAP-expression revealed no significant differences between both strains. However, compared to SD-rats, the blind SD/RCS animals significantly improved RHI and CLS by 6 - 12 weeks after SCI. To our surprise the withdrawal latencies in the blind SD/RCS rats were longer and the amplitudes of M- and H-waves lower. The expression of IBA1-immunoreactivity in the lumbar enlargement was lower than in the SD-animals. The longer withdrawal latencies suggest a decreased sensitivity in the blind SD/RCS rats, which

Intraocular gene transfer of ciliary neurotrophic factor rescues photoreceptor degeneration in RCS rats.

Science.gov (United States)

Huang, Shun-Ping; Lin, Po-Kang; Liu, Jorn-Hon; Khor, Chin-Ni; Lee, Yih-Jing

2004-01-01

Ciliary neurotrophic factor (CNTF) is known as an important factor in the regulation of retinal cell growth. We used both recombinant CNTF and an adenovirus carrying the CNTF gene to regulate retinal photoreceptor expression in a retinal degenerative animal, Royal College of Surgeons (RCS) rats. Cells in the outer nuclear layer of the retinae from recombinant-CNTF-treated, adenoviral-CNTF-treated, saline-operated, and contralateral untreated preparations were examined for those exhibiting CNTF photoreceptor protective effects. Cell apoptosis in the outer nuclear layer of the retinae was also detected. It was found that CNTF had a potent effect on delaying the photoreceptor degeneration process in RCS rats. Furthermore, adenovirus CNTF gene transfer was proven to be better at rescuing photoreceptors than that when using recombinant CNTF, since adenoviral CNTF prolonged the photoreceptor protection effect. The function of the photoreceptors was also examined by taking electroretinograms of different animals. Adenoviral-CNTF-treated eyes showed better retinal function than did the contralateral control eyes. This study indicates that adenoviral CNTF effectively rescues degenerating photoreceptors in RCS rats. Copyright 2004 National Science Council, ROC and S. Karger AG, Basel

Problemer med å måle eksponering for passiv røyking blant barn

Directory of Open Access Journals (Sweden)

Per Nafstad m.fl.

2009-10-01

Full Text Available  SAMMENDRAGVanligvis måles eksponering for passiv røyking blant barn ved spørreskjemaopplysninger omforeldres røykevaner. Etter hvert som det blir mer oppmerksomhet om helseeffekter av passivrøyking, vil det kunne påvirke hvordan foreldre røyker og dermed også barns eksponering. Medhenvisning til innsamlede data om røykeeksponering i en kohort av Oslo-barn og fra en studie avbarn ved to helsestasjoner, diskuteres noen av de metodeproblemene en står overfor når en skal måleeksponering for passiv røyking i epidemiologiske studier. I disse studiene er barns eksponering forpassiv røyking målt ved spørreskjemaopplysninger og ved måling av hårnikotin og kotinin i urin.Det konkluderes med at det er usikkerhet om nøyaktigheten av eksisterende metoder for måling avpassiv røyking. Dette og manglende kunnskap om faktisk eksponeringsnivå kan føre til feilaktigestimering av helseeffekter av passiv røyking i en barnebefolkning.Nafstad P, Botten G, Magnus P. Problems in measuring environmental tobacco smoke exposurein children. Nor J Epidemiol 1995; 5 (2: 141-144.ENGLISH SUMMARYUsually environmental tobacco smoke exposure among children is measuered by questionnaires,recording parental smoking. As the adverse health effects of environmental tobacco smoke exposureare getting more known among the public, this is likely to influence the parents' way of smoking andby that their children's actual exposure. With references to findings in a cohort study of Oslochildren and a study of children attending two of Oslo’s health centers, some methodologicalproblems when measuring environmental tobacco smoke exposure in epidemiological studies arediscussed. The exposure in these studies is measured in questionnaires to the parents and aschildren's hair nicotine concentration and urine cotinine concentration. Furthermore, the paperdiscusses how the uncertainty in actual levels of exposure may lead to false estimates for the totalhealth impact of

Anpassning av ett avgassystem för en motkolvstvåtaktsmotor med HCCI-förbränning

OpenAIRE

LAINEZ MARTÍ, JAVIER

2010-01-01

Målet för detta examensarbete har varit att förbättra driften av en motkolvs tvåtaktsmotormed HCCI-förbränning. Huvudfokus för arbetet har varit på gasväxlingsprocessen, dåfrämst avgasprocessen.Motorn har studerats med utgångspunkt från hur en tvåtakts Otto-cykel fungerar.Gasväxlingsprocessen i tvåtaktsmotorer kännetecknas av behovet av att snabbt få ut denförbrända gasen och införa ny blandning vid varje expansionstakt, samt avsaknaden avventiler. Behovet att kunna kontrollera gasflödet geno...

Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice.

Science.gov (United States)

Jia, Yuzhi; Chang, Hsiang-Chun; Schipma, Matthew J; Liu, Jing; Shete, Varsha; Liu, Ning; Sato, Tatsuya; Thorp, Edward B; Barger, Philip M; Zhu, Yi-Jun; Viswakarma, Navin; Kanwar, Yashpal S; Ardehali, Hossein; Thimmapaya, Bayar; Reddy, Janardan K

2016-01-01

Mediator, an evolutionarily conserved multi-protein complex consisting of about 30 subunits, is a key component of the polymerase II mediated gene transcription. Germline deletion of the Mediator subunit 1 (Med1) of the Mediator in mice results in mid-gestational embryonic lethality with developmental impairment of multiple organs including heart. Here we show that cardiomyocyte-specific deletion of Med1 in mice (csMed1-/-) during late gestational and early postnatal development by intercrossing Med1fl/fl mice to α-MyHC-Cre transgenic mice results in lethality within 10 days after weaning due to dilated cardiomyopathy-related ventricular dilation and heart failure. The csMed1-/- mouse heart manifests mitochondrial damage, increased apoptosis and interstitial fibrosis. Global gene expression analysis revealed that loss of Med1 in heart down-regulates more than 200 genes including Acadm, Cacna1s, Atp2a2, Ryr2, Pde1c, Pln, PGC1α, and PGC1β that are critical for calcium signaling, cardiac muscle contraction, arrhythmogenic right ventricular cardiomyopathy, dilated cardiomyopathy and peroxisome proliferator-activated receptor regulated energy metabolism. Many genes essential for oxidative phosphorylation and proper mitochondrial function such as genes coding for the succinate dehydrogenase subunits of the mitochondrial complex II are also down-regulated in csMed1-/- heart contributing to myocardial injury. Data also showed up-regulation of about 180 genes including Tgfb2, Ace, Atf3, Ctgf, Angpt14, Col9a2, Wisp2, Nppa, Nppb, and Actn1 that are linked to cardiac muscle contraction, cardiac hypertrophy, cardiac fibrosis and myocardial injury. Furthermore, we demonstrate that cardiac specific deletion of Med1 in adult mice using tamoxifen-inducible Cre approach (TmcsMed1-/-), results in rapid development of cardiomyopathy and death within 4 weeks. We found that the key findings of the csMed1-/- studies described above are highly reproducible in TmcsMed1-/- mouse heart

Food-Dependent Exercise-Induced Anaphylaxis - Kasuistik med hydrolyseret valleprotein

DEFF Research Database (Denmark)

Junker Christensen, Morten

2013-01-01

Formål / Introduktion: Patienter med Food-Dependent Exercise-Induced Anaphylaxis (FDEIA) eller løbershock kan udvikle livstruende allergiske reaktioner (anafylaksi), når de kombinere fysisk anstrengelse med samtidig indtagelse af et normalt tolereret fødeemne - oftest hvede. Hydrolysering af prot...

Spilleregler i musikterapi med voksne

DEFF Research Database (Denmark)

Holck, Ulla

2005-01-01

Artiklen gennemgår udvalgt faglitteratur, der på et overordnet plan beskriver typer af spilleregler i musikterapi med (fortrinsvis) voksne klientgrupper. Udgangspunktet er Priestleys anvendelse af begrebet, og hendes inddeling af spilleregler i forhold til forskellige teknikker gennemgås, efterfu...

Susceptibility of MED-Q1 and MED-Q3 Biotypes of Bemisia tabaci (Hemiptera: Aleyrodidae) Populations to Essential and Seed Oils.

Science.gov (United States)

Samuel Fogné, Drabo; Olivier, Gnankine; Bassolé, Imael H N; Nébié, Roger Charles; Laurence, Mouton

2017-06-01

Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) is a major pest of many agricultural and ornamental crops in tropical and subtropical regions causing damages that result in important economic losses. Insecticides are commonly used in greenhouses or fields to control B. tabaci populations leading to rapid evolution of resistance that render treatments inefficient. Therefore, and for environmental and human health concerns, other approaches must be developed for this pest management. In the present study, we compare, using the leaf dip method, the toxicity of three essential oils (Cymbopogon citratus, Ocimum americanum, and Hyptis spicigera) and three seed oils (Lannea microcarpa, Lannea acida, and Carapa procera) with three chemical insecticides (acetamiprid, deltamethrin, and chlorpyrifos-ethyl) on adults. Two B. tabaci biotypes (MED-Q1 and MED-Q3) belonging to the Mediterranean species and collected in Burkina Faso were used. Essential oils were analyzed by gas chromatography-mass spectrometry and gas chromatography-flame ionization detector. We showed that these two biotypes have different levels of resistance to the three insecticides, MED-Q3 being more sensitive than MED-Q1. Moreover, they differ in the frequency of resistance alleles to insecticides, especially for organophosphates, as these alleles are almost fixed in MED-Q1. On the other hand, the two biotypes prove to be more susceptible to the plant extracts than to insecticides except for chlorpyrifos-ethyl, with essential oils that showed the highest insecticidal activities. Monoterpenes content were the most abundant and showed the highest insecticidal activities. Our results indicated that essential oils, but also seed oils, have the potential to constitute an alternative strategy of pest management. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Mitigation action plan for 300-FF-1 remedial action

International Nuclear Information System (INIS)

Weiss, S.G.

1996-10-01

A record of decision was issued (dated July 1996), for remediation of waste sites in the 300-FF-1 Operable Unit in the 300 Area of the Hanford Site. The selected remedies for the 300-FF-1 and 300-FF-5 waste sites include selective excavation and disposal of contaminated soil and debris from the process waste units, excavation and removal of the 618-4 Burial Ground, and institutional controls for groundwater. This mitigation action plan explains how cultural resources will be managed and how revegetation for these remedial activities will be planned

The MEDIATOR genes MED12 and MED13 control Arabidopsis root system configuration influencing sugar and auxin responses.

Science.gov (United States)

Raya-González, Javier; López-Bucio, Jesús Salvador; Prado-Rodríguez, José Carlos; Ruiz-Herrera, León Francisco; Guevara-García, Ángel Arturo; López-Bucio, José

2017-09-01

Arabidopsis med12 and med13 mutants exhibit shoot and root phenotypes related to an altered auxin homeostasis. Sucrose supplementation reactivates both cell division and elongation in primary roots as well as auxin-responsive and stem cell niche gene expression in these mutants. An analysis of primary root growth of WT, med12, aux1-7 and med12 aux1 single and double mutants in response to sucrose and/or N-1-naphthylphthalamic acid (NPA) placed MED12 upstream of auxin transport for the sugar modulation of root growth. The MEDIATOR (MED) complex plays diverse functions in plant development, hormone signaling and biotic and abiotic stress tolerance through coordination of transcription. Here, we performed genetic, developmental, molecular and pharmacological analyses to characterize the role of MED12 and MED13 on the configuration of root architecture and its relationship with auxin and sugar responses. Arabidopsis med12 and med13 single mutants exhibit shoot and root phenotypes consistent with altered auxin homeostasis including altered primary root growth, lateral root development, and root hair elongation. MED12 and MED13 were required for activation of cell division and elongation in primary roots, as well as auxin-responsive and stem cell niche gene expression. Remarkably, most of these mutant phenotypes were rescued by supplying sucrose to the growth medium. The growth response of primary roots of WT, med12, aux1-7 and med12 aux1 single and double mutants to sucrose and application of auxin transport inhibitor N-1-naphthylphthalamic acid (NPA) revealed the correlation of med12 phenotype with the activity of the auxin intake permease and suggests that MED12 acts upstream of AUX1 in the root growth response to sugar. These data provide compelling evidence that MEDIATOR links sugar sensing to auxin transport and distribution during root morphogenesis.

"Toore puuga kütmine on raiskamine ..." = "Att elda med sur ved är slöseri ..." : [luuletused] / Gunnar D. Hansson ; tlk. Mati Sirkel

Index Scriptorium Estoniae

Hansson, Gunnar D.

2004-01-01

Sisu: "Toore puuga kütmine on raiskamine ..." = "Att elda med sur ved är slöseri ..."; "Esimest päeva rändab tuul ..." = "Första dagen vandrar vinden ..."; "Päike tuli lähemale ..." = "Solen kom närmare ..."; "Nagu oleks kõik möödas ..." = "Som om allt vore över ..."

Numerical simulation of RCS for carrier electronic warfare airplanes

Directory of Open Access Journals (Sweden)

Yue Kuizhi

2015-04-01

Full Text Available This paper studies the radar cross section (RCS of carrier electronic warfare airplanes. Under the typical naval operations section, the mathematical model of the radar wave’s pitch angle incidence range analysis is established. Based on the CATIA software, considering dynamic deflections of duck wing leading edge flaps, flaperons, horizontal tail, and rudder, as well as aircraft with air-to-air missile, anti-radiation missile, electronic jamming pod, and other weapons, the 3D models of carrier electronic warfare airplanes Model A and Model B with weapons were established. Based on the physical optics method and the equivalent electromagnetic flow method, by the use of the RCSAnsys software, the characteristics of carrier electronic warfare airplanes’ RCS under steady and dynamic flights were simulated under the UHF, X, and S radar bands. This paper researches the detection probability of aircraft by radars under the condition of electronic warfare, and completes the mathematical statistical analysis of the simulation results. The results show that: The Model A of carrier electronic warfare airplane is better than Model B on stealth performance and on discover probability by radar detection effectively.

Silencing MED1 sensitizes breast cancer cells to pure anti-estrogen fulvestrant in vitro and in vivo.

Directory of Open Access Journals (Sweden)

Lijiang Zhang

Full Text Available Pure anti-estrogen fulvestrant has been shown to be a promising ER antagonist for locally advanced and metastatic breast cancer. Unfortunately, a significant proportion of patients developed resistance to this type of endocrine therapy but the molecular mechanisms governing cellular responsiveness to this agent remain poorly understood. Here, we've reported that knockdown of estrogen receptor coactivator MED1 sensitized fulvestrant resistance breast cancer cells to fulvestrant treatment. We found that MED1 knockdown further promoted cell cycle arrest induced by fulvestrant. Using an orthotopic xenograft mouse model, we found that knockdown of MED1 significantly reduced tumor growth in mice. Importantly, knockdown of MED1 further potentiated tumor growth inhibition by fulvestrant. Mechanistic studies indicated that combination of fulvestrant treatment and MED1 knockdown is able to cooperatively inhibit the expression of ER target genes. Chromatin immunoprecipitation experiments further supported a role for MED1 in regulating the recruitment of RNA polymerase II and transcriptional corepressor HDAC1 on endogenous ER target gene promoter in the presence of fulvestrant. These results demonstrate a role for MED1 in mediating resistance to the pure anti-estrogen fulvestrant both in vitro and in vivo.

Explosion i rötkammare med biogas

DEFF Research Database (Denmark)

Hedlund, Frank Huess

2017-01-01

En biogasreaktor exploderade 1990 på Vejle Centrala reningsverk. Nu, 24 år senare, när biogas är populärare än någonsin, har händelsen helt försvunnit från tillgängliga, öppna källor......En biogasreaktor exploderade 1990 på Vejle Centrala reningsverk. Nu, 24 år senare, när biogas är populärare än någonsin, har händelsen helt försvunnit från tillgängliga, öppna källor...

Fuzzy-4D/RCS for Unmanned Aerial Vehicles

OpenAIRE

Olivares Mendez, Miguel Angel; Campoy, Pascual; Mondragon, Ivan F.; Martinez, Carol

2010-01-01

Abstract This paper presents an improvement of the cognitive architecture, 4D/RCS, developed by the NIST. This improvement consist of the insertion of Fuzzy Logic cells (FLCs), in different parts and hierarchy levels of the architecture, and the adaptation of this architecture for Unmanned Aerial Vehicles (UAVs). This advance provides an improvement in the functionality of the system based on the uses of the Miguel Olivares’ Fuzzy Software for the definition of the FLCs and its...

Analysis of PubMed User Sessions Using a Full-Day PubMed Query Log: A Comparison of Experienced and Nonexperienced PubMed Users

Science.gov (United States)

2015-01-01

Background PubMed is the largest biomedical bibliographic information source on the Internet. PubMed has been considered one of the most important and reliable sources of up-to-date health care evidence. Previous studies examined the effects of domain expertise/knowledge on search performance using PubMed. However, very little is known about PubMed users’ knowledge of information retrieval (IR) functions and their usage in query formulation. Objective The purpose of this study was to shed light on how experienced/nonexperienced PubMed users perform their search queries by analyzing a full-day query log. Our hypotheses were that (1) experienced PubMed users who use system functions quickly retrieve relevant documents and (2) nonexperienced PubMed users who do not use them have longer search sessions than experienced users. Methods To test these hypotheses, we analyzed PubMed query log data containing nearly 3 million queries. User sessions were divided into two categories: experienced and nonexperienced. We compared experienced and nonexperienced users per number of sessions, and experienced and nonexperienced user sessions per session length, with a focus on how fast they completed their sessions. Results To test our hypotheses, we measured how successful information retrieval was (at retrieving relevant documents), represented as the decrease rates of experienced and nonexperienced users from a session length of 1 to 2, 3, 4, and 5. The decrease rate (from a session length of 1 to 2) of the experienced users was significantly larger than that of the nonexperienced groups. Conclusions Experienced PubMed users retrieve relevant documents more quickly than nonexperienced PubMed users in terms of session length. PMID:26139516

Observations of electrons in the Intense Pulse Neutron Source (IPNS) Rapid Cycling Synchrotron (RCS)

International Nuclear Information System (INIS)

Dooling, J.C.; Brumwell, F.R.; Czyz, W.S.; Harkay, K.C.; Lien, M.K.; McMichael, G.E.

2004-01-01

In the process of accelerating protons from 50 to 450 MeV at 30 Hz, low-energy electrons are generated within the IPNS RCS vacuum chamber. Electrons from background gas stripping are detected using an Ionization Profile Monitor (IPM) to generate integrated, horizontal charge distributions of the single-harmonic bunch during acceleration. Recently, a Retarding Field Analyzer (RFA) was installed in the RCS to look for evidence of beam-induced multipacting by measuring the electrons ejected by the space charge of the beam. A wide-band, high-gain transimpedance amplifier has been built to observe time structure in the electron signal detected with the RFA. Though a noisy power supply prevented full I-V characteristics from being obtained, interesting features are observed; especially, after the period of phase modulation between the rf cavities that is deliberately introduced during the cycle. The phase modulation generates a longitudinal quadrupole oscillation in the bunch, which is believed to enhance beam stability. Preliminary results indicate that electron multipacting is not significant in the RCS. The effects of background gas neutralization are considered and details of the RFA measurements are presented.

Space Shuttle RCS Oxidizer Leak Repair for STS-26

Science.gov (United States)

Delventhal, R. A.; Faget, N. M.

1989-01-01

Following propellant loading of the Space Shuttle's reaction control system (RCS) for mission STS 26, an oxidizer leak was detected in the left orbital maneuvering system (OMS) pod, where the RCS is located. Subsequent investigation determined that the leak was isolated at a mechanical Dynatube fitting near the RCS nitrogen tetroxide tank. An intense effort was initiated to design, fabricate, and qualify a sealing device to stop the oxidizer leak externally so that the Space Shuttle launch could proceed. It was discovered that sealing devices called clamshells were widely used throughout the petrochemical and power generation industries to stop leaks developed in large diameter pipes which carry steam or other hazardous fluids. These clamshells are available in different diameters and strengths and are placed around the pipe at the location of the leak. A sealing compound is then injected under high pressure into the clamshell to stop the leak. This technology was scaled down and applied to the problem of stopping the leak on the Orbiter, which was on a half-inch diameter line in a nearly inaccessible location. Many obstacles had to be overcome such as determining that the sealing material would be compatible with the nitrogen tetroxide and ensuring that the clamshell would actually fit around the Dynatube fitting without interfering with other lines which were in close proximity. The effort at the NASA Johnson Space Center included materials compatibility testing of several sealants, design of a clamshell to fit in the confined compartment, and manufacture and qualification of the flight hardware. A clamshell was successfully placed around the Dynatube fitting on the Orbiter and the oxidizer leak was terminated. Then it was decided to apply this technology further and design clamshells for other mechanical fittings onboard the Orbiter and develop sealing compounds which will be compatible with fuels such as monomethyl hydrazine (MMH). The potential exists for

Polarized e-bunch acceleration at Cornell RCS: Tentative tracking simulations

Energy Technology Data Exchange (ETDEWEB)

Meot, F. [Brookhaven National Lab. (BNL), Upton, NY (United States); Ptitsyn, V. [Brookhaven National Lab. (BNL), Upton, NY (United States); Ranjbar, V. [Brookhaven National Lab. (BNL), Upton, NY (United States); Rubin, D. [Brookhaven National Lab. (BNL), Upton, NY (United States)

2017-10-19

An option as an injector into eRHIC electron storage ring is a rapid-cyclic synchrotron (RCS). Rapid acceleration of polarized electron bunches has never been done, Cornell synchrotron might lend itself to dedicated tests, which is to be first explored based on numerical investigations. This paper is a very preliminary introduction to the topic.

Eksplosion i rådnetank med biogas

DEFF Research Database (Denmark)

Hedlund, Frank Huess

2015-01-01

En rådnetank på Vejle Centralrenseanlæg eksploderede i 1990, mens håndværkere arbejdede på taget. Nu, 24 år senere, hvor biogas er populært som aldrig før, er hændelsen fuldstændig forsvundet fra tilgængelige åbne kilder.......En rådnetank på Vejle Centralrenseanlæg eksploderede i 1990, mens håndværkere arbejdede på taget. Nu, 24 år senere, hvor biogas er populært som aldrig før, er hændelsen fuldstændig forsvundet fra tilgængelige åbne kilder....

Eksplosion i rådnetank med biogas

DEFF Research Database (Denmark)

Hedlund, Frank Huess

2014-01-01

En rådnetank på Vejle Centralrenseanlæg eksploderede i 1990, mens håndværkere arbejdede på taget. Nu, 24 år senere, hvor biogas er populært som aldrig før, er hændelsen fuldstændig forsvundet fra tilgængelige åbne kilder.......En rådnetank på Vejle Centralrenseanlæg eksploderede i 1990, mens håndværkere arbejdede på taget. Nu, 24 år senere, hvor biogas er populært som aldrig før, er hændelsen fuldstændig forsvundet fra tilgængelige åbne kilder....

LIVIVO: Neue Herausforderungen an das ZB MED-Suchportal für Lebenswissenschaften

Directory of Open Access Journals (Sweden)

Poley, Christoph

2016-12-01

Full Text Available The German National Library of Medicine (ZB MED has a long track record providing search portals for life sciences. In 2015 LIVIVO was introduced as a new product, which database covers ZB MED’s entire range of subjects: medicine, health, nutrition, environment and agriculture.Initially LIVIVO’s development aimed at realizing a modern search engine combining the functionalities of the predecessor portals. An entirely new web interface was developed, driven by a highly improved usability and a responsive web design. LIVIVO has a great potential in providing search services based on more than 55 million metadata records. Current work of ZB MED focuses on automatic interfaces. Concurrently setting up ZB MED Knowledge Environment creates an indispensable data base for research work at .This article will address the current challenges of a scientific portal using the example of LIVIVO. It will outline the approaches to solutions and development lines.

Grafting of ARPE-19 and Schwann cells to the subretinal space in RCS rats.

Science.gov (United States)

Wang, Shaomei; Lu, Bin; Wood, Patrick; Lund, Raymond D

2005-07-01

To study the distribution of the human retinal pigment epithelium (hRPE) cell line ARPE-19 and human Schwann (hSC) cells grafted to the subretinal space of the Royal College of Surgeon (RCS) rat and the relation of graft cell distribution to photoreceptor rescue. Cell suspensions of both donor types were injected into the subretinal space of 3-week-old dystrophic RCS rats through a transscleral approach, human fibroblast and medium were used as control grafts. All animals were maintained on oral cyclosporine. At 1, 2, 4, 6, 15, 28, and 36 weeks after grafting, animals were killed. Human cell-specific markers were used to localize donor cells. Both donor cell types, as revealed by antibodies survived for a substantial time. Their distribution was very different: hRPE cells formed a large clump early on and, with time, spread along the host RPE in a layer one to two cells deep, whereas hSCs formed many smaller clumps, mainly in the subretinal space. Both cells rescued photoreceptors beyond the area of donor cell distribution. The number of surviving cells declined with time. Both hRPE and hSC grafts can survive and rescue photoreceptors for a substantial time after grafting. The number of both donor cell types declined with time, which could be an immune-related problem and/or due to other factors intrinsic to the host RCS retina. The fact that rescue occurred beyond the area of donor cell distribution suggests that diffusible factors are involved, raising the possibility that the two cell types function in a similar manner to rescue photoreceptors.

Med politiet i ’virkeligheden’: Reality-tv og kriminalitet

Directory of Open Access Journals (Sweden)

Ib Bondebjerg

2002-09-01

Full Text Available Kriminalstoffet på tv bliver ofte anklaget for at spekulere i vore lavere instinkter, og med reality kommer vi tættere end nogensinde på sam- fundets bund og det utrættelige politi, som har til opgave at opretholde lov og orden. Artiklen gennemgår en lang række af de senere års kri- minalprogrammer og diskuterer dokumentarismens former med en særlig belysning af æstetik, retorik og synsvinkel i undergenrerne »reality magasin« og »reality soap«. Lars Engels’ serie »Historier fra en politistation« tages op til særlig debat, fordi Engels – vanen tro – arbejder med en mindre iscenesættelse og ukommenteret virkelig- hedsgengivelse, end vi finder det i andre »reality soaps«.

Investigation of 3-D RCS Image formation of ships using ISAR

CSIR Research Space (South Africa)

Lord, RT

2006-05-01

Full Text Available Conventional Inverse Synthetic Aperture Radar (ISAR) utilises the rotational motion of a target such as a ship or an aircraft to obtain a 2-D image of the target’s radar cross section (RCS) profile from a coherent radar system. This concept can...

Förhållandet mellan den fria rörligheten inom EU och internationella dubbelbeskattningsavtal : En analys med utgångspunkt i EU-domstolens praxis

OpenAIRE

Österman, Catharina

2013-01-01

När en skattskyldig blir beskattad flera gånger för samma inkomst, i minst två länder och under samma tidsperiod, uppstår juridisk dubbelbeskattning. En vanlig metod för att i möjligaste mån undvika dubbelbeskattning är att stater ingår bilaterala dubbelbeskattningsavtal med varandra. I ett dubbelbeskattningsavtal avgör de avtalsslutande staterna vilken stat som, i en rad olika situationer, ska ha beskattningsrätt och vilken stat som till följd därav avstår från sin rätt till beskattning. Där...

EU-retlige og forvaltningsretlige aspekter ved kommunernes tilsyn med taxiførere

DEFF Research Database (Denmark)

Sørensen, Henning Fuglsang

2011-01-01

Afhandlingen gennemgår taxilovens krav til kommunernes tilsyn med førere af taxier, herunder særligt de eu-retlige og forvaltningsretlige problemer i dette tilsyn.......Afhandlingen gennemgår taxilovens krav til kommunernes tilsyn med førere af taxier, herunder særligt de eu-retlige og forvaltningsretlige problemer i dette tilsyn....

Nye steder med liv og sjæl?

DEFF Research Database (Denmark)

Stender, Marie

planlæggere, der har skabt dem, udforskes stedernes tilblivelsesproces og sociale liv. Det nye sted opfattes af både beboere og professionelle som en bar mark, og mange kræfter sættes ind på at genfortrylle det med et skær af liv, identitet og historie fra start. Hånd i hånd med branding, virtuelle fora...

10 CFR 300.1 - General.

Science.gov (United States)

2010-01-01

... CLIMATE CHANGE VOLUNTARY GREENHOUSE GAS REPORTING PROGRAM: GENERAL GUIDELINES § 300.1 General. (a) Purpose... Policy Act of 1992 (42 U.S.C. 13385(b)). The purpose of the guidelines is to establish the procedures and... organizations, households and other private and public entities to submit annual reports of their greenhouse gas...

Förändrat omhändertagande av patienter med uretärsten : - Lärdomar från ett förbättringsarbete

OpenAIRE

Khatami, Annelie

2014-01-01

Bakgrund: Omkring 10-15 % av befolkningen, oftast i arbetsför ålder, riskerar att någon gång drabbas av njursten. Nationella riktlinjer för njurstensbehandling saknas, men studier stödjer behandling inom 48 timmar för snabb symtomlindring och minskade besvär för patienten. Inom studerad verksamhet var tiden från diagnos till behandling lång och återinläggningarna var många, varför ett förbättringsarbete initierades. Syfte: Syftet med förbättringsarbetet var att halvera tiden från diagnos till...

Characterization of the rcsA Gene from Pantoea sp. Strain PPE7 and Its Influence on Extracellular Polysaccharide Production and Virulence on Pleurotus eryngii

Directory of Open Access Journals (Sweden)

Min Keun Kim

2017-06-01

Full Text Available RcsA is a positive activator of extracellular polysaccharide (EPS synthesis in the Enterobacteriaceae. The rcsA gene of the soft rot pathogen Pantoea sp. strain PPE7 in Pleurotus eryngii was cloned by PCR amplification, and its role in EPS synthesis and virulence was investigated. The RcsA protein contains 3 highly conserved domains, and the C-terminal end of the open reading frame shared significant amino acid homology to the helix-turn-helix DNA binding motif of bacterial activator proteins. The inactivation of rcsA by insertional mutagenesis created mutants that had decreased production of EPS compared to the wild-type strain and abolished the virulence of Pantoea sp. strain PPE7 in P. eryngii. The Pantoea sp. strain PPE7 rcsA gene was shown to strongly affect the formation of the disease symptoms of a mushroom pathogen and to act as the virulence factor to cause soft rot disease in P. eryngii.

The internalization of posterior subcapsular cataracts (PSCs) in Royal College of Surgeons (RCS) rats. II. The inter-relationship of optical quality and structure as a function of age.

Science.gov (United States)

Kuszak, J R; Al-Ghoul, K J; Novak, L A; Peterson, K L; Herbert, K L; Sivak, J G

1999-05-06

The Royal College of Surgeons (RCS) rat is an animal model for human retinal degenerative disease and posterior subcapsular cataracts (PSCs). The purpose of this study was to correlate the structure and optical quality of RCS lenses with PSCs as a function of their internalization, with normal, non-cataractous, age-matched control lenses. Correlative light (LM), scanning electron microscopic (SEM), three-dimensional computer assisted drawings (3D-CADs) and low power helium-neon laser scan analysis were used to examine the structure and function of lenses. The optical properties (average focal length variability; sharpness of focus) of RCS rat lenses are quantitatively compromised by PSCs. Correlative LM and SEM analysis of RCS lenses at various stages of PSC internalization (1.5, 3, 6, 9, 12 and 15 months of age), revealed that the sutures formed by additional fiber growth were progressively more abnormal. During PSC internalization, two to nine small suture branches were formed and arranged in modified line to multiple y configurations rather than the normal three branch y sutures. These temporal changes were also chronicled in animated 3D-CAD videos derived from lens reconstructions based on LM and SEM micrographs from the selected time points stated above. However, laser scan analysis also revealed that as the PSCs of RCS rat lenses were progressively internalized, there was a steady improvement in total sharpness of focus that reached normal levels by 12 months of age. The correlation of laser scan and structural data from specific regions of lenses revealed the following: 1. The abnormal posterior sutures of RCS rats with internalized PSCs effect a greater reduction in optical quality than normal posterior sutures of age-matched controls; 2. However, the resulting abnormal suture plane area was cumulatively similar to that of age-matched controls; 3. Thus, total optical quality was similar between RCS lenses with internalized PSCs and age-matched controls by

Mediator subunit MED1 is a T3-dependent and T3-independent coactivator on the thyrotropin β gene promoter

Energy Technology Data Exchange (ETDEWEB)

Matsui, Keiji; Oda, Kasumi; Mizuta, Shumpei; Ishino, Ruri; Urahama, Norinaga; Hasegawa, Natsumi [Laboratory of Hematology, Division of Medical Biophysics, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Suma-ku, Kobe 654-0142 (Japan); Roeder, Robert G. [Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065 (United States); Ito, Mitsuhiro, E-mail: itomi@med.kobe-u.ac.jp [Laboratory of Hematology, Division of Medical Biophysics, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Suma-ku, Kobe 654-0142 (Japan); Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065 (United States); Department of Family and Community Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 654-0142 (Japan); Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 159-8555 (Japan)

2013-10-11

Highlights: •MED1 is a bona fide T3-dependent coactivator on TSHB promoter. •Mice with LxxLL-mutant MED1 have attenuated TSHβ mRNA and thyroid hormone levels. •MED1 activates TSHB promoter T3-dependently in cultured cells. •T3-dependent MED1 action is enhanced when SRC1/SRC2 or HDAC2 is downregulated. •MED1 is also a T3-independent GATA2/Pit1 coactivator on TSHB promoter. -- Abstract: The MED1 subunit of the Mediator transcriptional coregulator complex is a nuclear receptor-specific coactivator. A negative feedback mechanism of thyroid-stimulating hormone (TSH, or thyrotropin) expression in the thyrotroph in the presence of triiodothyronine (T3) is employed by liganded thyroid hormone receptor β (TRβ) on the TSHβ gene promoter, where conventional histone-modifying coactivators act as corepressors. We now provide evidence that MED1 is a ligand-dependent positive cofactor on this promoter. TSHβ gene transcription was attenuated in MED1 mutant mice in which the nuclear receptor-binding ability of MED1 was specifically disrupted. MED1 stimulated GATA2- and Pit1-mediated TSHβ gene promoter activity in a ligand-independent manner in cultured cells. MED1 also stimulated transcription from the TSHβ gene promoter in a T3-dependent manner. The transcription was further enhanced when the T3-dependent corepressors SRC1, SRC2, and HDAC2 were downregulated. Hence, MED1 is a T3-dependent and -independent coactivator on the TSHβ gene promoter.

Glow experiment documentation of OMS/RCS pod and vertical stabilizer

Science.gov (United States)

1982-01-01

Glow experiment documentation of one of the orbital maneuvering system (OMS) reaction control system (RCS) pods and a portion of the vertical stabilizer shows chemoluminescent effectresulting from atomic oxygen impacting the spacecraft and building to the point that the atomic oxygen atoms combine to form molecules of oxygen. The Image Intensifier on NIKON 35mm camera was used to record the glow.

Glow experiment documentation of OMS/RCS pods and vertical stabilizer

Science.gov (United States)

1982-01-01

Glow experiment documentation of orbital maneuvering system (OMS) reaction control system (RCS) pods and vertical stabilizer shows chemo-luminescent effect resulting from atomic oxygen impacting the spacecraft and building to the point that the atomic oxygen atoms combine to form molecules of oxygen. Image intensifier on NIKON 35mm camera was used to record glow on vertical tail and OMS pods.

Ny viden begynder med forhindringer

DEFF Research Database (Denmark)

Johansen, Martin Blok

2017-01-01

Pædagogik og pædagogisk arbejde diskuteres typisk inden for rammerne af det at hjælpe, støtte, simplificere og kompleksitetsreducere. Hvis man ønsker at vide noget om forhindringer, modstand og vanskeligheder som pædagogiske muligheder, så er udbuddet derimod forsvindende småt. Og når sådanne...... begreber endelig tages op, så benævnes de typisk blot, men bliver sjældent defineret. Hvad menes der med modstand, vanskeligheder eller kompleksitet? Med afsæt i en kort gennemgang af eksisterende forskning på området forsøger denne artikel at give et bud på en mulig definition af begrebet forhindring...

Manifest for en psykiatri med brugerrespekt

DEFF Research Database (Denmark)

Samskabelsesprojekt med psykiatribrugere og pårørende. Psykiatri Manifestet består af forskellige statements om psykiatrien som den opleves set fra brugerperspektiv, og visioner om hvor brugerne ønsker, den skal udvikle sig hen. Brugerne har reageret på Marianne Træbing Sechers invitation via hen...... hendes kontoer på Facebook, Twitter og LinkedIn, samt gennem nedenstående facebooksider og interesseorganisationer. Marianne er ansat som adjunkt på VIA University College og står for videreuddannelse, konsulentarbejde og forskning/udvikling på psykiatriområdet i tilknytning hertil....

The Mediator Complex MED15 Subunit Mediates Activation of Downstream Lipid-Related Genes by the WRINKLED1 Transcription Factor.

Science.gov (United States)

Kim, Mi Jung; Jang, In-Cheol; Chua, Nam-Hai

2016-07-01

The Mediator complex is known to be a master coordinator of transcription by RNA polymerase II, and this complex is recruited by transcription factors (TFs) to target promoters for gene activation or repression. The plant-specific TF WRINKLED1 (WRI1) activates glycolysis-related and fatty acid biosynthetic genes during embryogenesis. However, no Mediator subunit has yet been identified that mediates WRI1 transcriptional activity. Promoter-β-glucuronidase fusion experiments showed that MEDIATOR15 (MED15) is expressed in the same cells in the embryo as WRI1. We found that the Arabidopsis (Arabidopsis thaliana) MED15 subunit of the Mediator complex interacts directly with WRI1 in the nucleus. Overexpression of MED15 or WRI1 increased transcript levels of WRI1 target genes involved in glycolysis and fatty acid biosynthesis; these genes were down-regulated in wild-type or WRI1-overexpressing plants by silencing of MED15 However, overexpression of MED15 in the wri1 mutant also increased transcript levels of WRI1 target genes, suggesting that MED15 also may act with other TFs to activate downstream lipid-related genes. Chromatin immunoprecipitation assays confirmed the association of MED15 with six WRI1 target gene promoters. Additionally, silencing of MED15 resulted in reduced fatty acid content in seedlings and mature seeds, whereas MED15 overexpression increased fatty acid content in both developmental stages. Similar results were found in wri1 mutant and WRI1 overexpression lines. Together, our results indicate that the WRI1/MED15 complex transcriptionally regulates glycolysis-related and fatty acid biosynthetic genes during embryogenesis. © 2016 American Society of Plant Biologists. All Rights Reserved.

Folkeskolens opgaver overfor børn med forskellig social, etnisk og kultur baggrund

DEFF Research Database (Denmark)

Tireli, Üzeyir

2012-01-01

Med udgangspukt i en case om romapige fremhæves det, at skolen og lærerne stigmatiserer elever med en anden baggrund end etnisk dansk. Det betyder, at skolen i fremtiden står overfor en stor ligestillingsopgave, da prognoser tyder på øget indvandring. Der kan derfor let opstår øgede forskelle mel...

Numerical simulation of RCS for carrier electronic warfare airplanes

OpenAIRE

Yue Kuizhi; Liu Wenlin; Li Guanxiong; Ji Jinzu; Yu Dazhao

2015-01-01

This paper studies the radar cross section (RCS) of carrier electronic warfare airplanes. Under the typical naval operations section, the mathematical model of the radar wave’s pitch angle incidence range analysis is established. Based on the CATIA software, considering dynamic deflections of duck wing leading edge flaps, flaperons, horizontal tail, and rudder, as well as aircraft with air-to-air missile, anti-radiation missile, electronic jamming pod, and other weapons, the 3D models of carr...

41 CFR 300-2.1 - What formats exist in the FTR?

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What formats exist in the FTR? 300-2.1 Section 300-2.1 Public Contracts and Property Management Federal Travel Regulation System GENERAL INTRODUCTION 2-HOW TO USE THE FTR General § 300-2.1 What formats exist in the FTR? The FTR...

Analysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant role of STAT1 in FGFR3 signaling in cartilage.

Directory of Open Access Journals (Sweden)

Pavel Krejci

Full Text Available Activating mutations in FGFR3 tyrosine kinase cause several forms of human skeletal dysplasia. Although the mechanisms of FGFR3 action in cartilage are not completely understood, it is believed that the STAT1 transcription factor plays a central role in pathogenic FGFR3 signaling. Here, we analyzed STAT1 activation by the N540K, G380R, R248C, Y373C, K650M and K650E-FGFR3 mutants associated with skeletal dysplasias. In a cell-free kinase assay, only K650M and K650E-FGFR3 caused activatory STAT1(Y701 phosphorylation. Similarly, in RCS chondrocytes, HeLa, and 293T cellular environments, only K650M and K650E-FGFR3 caused strong STAT1 activation. Other FGFR3 mutants caused weak (HeLa or no activation (293T and RCS. This contrasted with ERK MAP kinase activation, which was strongly induced by all six mutants and correlated with the inhibition of proliferation in RCS chondrocytes. Thus the ability to activate STAT1 appears restricted to the K650M and K650E-FGFR3 mutants, which however account for only a small minority of the FGFR3-related skeletal dysplasia cases. Other pathways such as ERK should therefore be considered as central to pathological FGFR3 signaling in cartilage.

Lærere arbejder med landskabsdannelse

DEFF Research Database (Denmark)

2012-01-01

Valg af materiale/medie/form: YOUtube videoklip. Valg af arbejdsform: Lærere der er igang med at afprøve praktisk undersøgende arbejde med danske landskabsformer. Begrundelse for valg af materiale/medie/form/arbejdsform: Ultrakort videoklip valgt så 1) lærerne kan dele med kolleger, 2) øvrige...

Hvad stiller vi op med samfundsneurosen?

DEFF Research Database (Denmark)

Jensen, Niels Rosendal

2008-01-01

Pædagogisk og socialt arbejde er som aldrig før udsat for evaluering, accountability, akkreditering m.v.  Det fjerner opmærksomheden fra kerneopgaven, at de professionelles ydelser forbedres. Forhistorien opridses kort, og klummen afrundes med at pege på tre mulige veje ud af samfundsneurosen: et...

Beskrivelse af næringsstofomsætning med metabolomics

DEFF Research Database (Denmark)

Hedemann, Mette Skou

2010-01-01

I et forsøg med mink med lav eller høj foderkonvertering er der blevet taget blodprøver på tre tidspunkter. Blodprøverne er blevet taget i en periode, hvor minkene er blevet fodret restriktivt (en prøve) og i en periode med ad libitum fodring (to prøver). Blodprøverne blev analyseret ved hjælp af...... fra restriktivt fodrede mink end i plasma fra ad libitum fodrede mink - betain og carnitin. Derudover er der en lang række andre metabolitter, som også findes i forskellig koncentration som endnu ikke er identificeret....

Changes of the vasculature and innervation in the anterior segment of the RCS rat eye.

Science.gov (United States)

May, Christian Albrecht

2011-12-01

Investigating the anterior eye segment vasculature and innervation of dystrophic RCS rats, two major unique findings were observed: in the iris, young adult animals with retinal dystrophy showed an increase in substance P nerve fibres and a dilation of arterioles and capillaries. This finding continued during ageing. In the pars plana region, the surface covered by venules decreased continuously with age. In older animals, this decrease was parallelled by a local decrease of sympathetic TH-positive nerve fibres supplying these venules. For both conditions, no comparable data exists so far in the literature. They might point to a unique situation in the anterior eye segment of the dystrophic RCS rat. Copyright © 2011 Elsevier Ltd. All rights reserved.

Overall view of PLB and OMS / RCS engine thrusting

Science.gov (United States)

1983-01-01

Overall payload bay (PLB) view shows Inertial Upper Stage (IUS) Airborne Support Equipment (ASE) forward frame and aft frame tilt actuator (AFTA) table after IUS Tracking and Data Relay Satellite (TDRS) deploy. Vertical tail and Orbital Maneuvering System (OMS) pods with rear reaction control system (RCS) thruster firing (sidefiring) appears in background against blackness of space. Right right jet firing was photographed from more than 18 meters (60 feet) away in the cabin of the Earth-orbiting Challenger, Orbiter Vehicle (OV) 099.

Applications of medical wireless LAN systems (MedLAN)

OpenAIRE

Banitsas, KA; Istepanian, RSH; Tachakra, S

2002-01-01

This is a post-peer-review, pre-copyedit version of an article published in Journal of Medical Marketing. The definitive publisher-authenticated version "Konstantinos A. Banitsas, R.S.H. Istepanian, Sapal Tachakra. Applications of medical Wireless LAN systems (MedLAN). Journal of Medical Marketing, Volume 2, Number 2, 1 January 2002 , pp. 136-142(7)" is available online at: http://www.ingentaconnect.com/content/pal/jomm/2002/00000002/00000002/art00008. In this paper the Wireless LAN (WLAN)...

DMPD: Pellino proteins: novel players in TLR and IL-1R signalling. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 17635639 Pellino proteins: novel players in TLR and IL-1R signalling. Schauvliege R..., Janssens S, Beyaert R. J Cell Mol Med. 2007 May-Jun;11(3):453-61. (.png) (.svg) (.html) (.csml) Show Pellino proteins: novel player...s in TLR and IL-1R signalling. PubmedID 17635639 Title Pellino proteins: novel player...tml) CSML File (.csml) Open .csml file with CIOPlayer Open .csml file with CIOPlayer - ※CIO Playerのご利用上の注意 Open .csml file with CIO Open .csml file with CIO - ※CIOのご利用上の注意 ...

The Quantitative Reasoning for College Science (QuaRCS) Assessment: Emerging Themes from 5 Years of Data

Science.gov (United States)

Follette, Katherine; Dokter, Erin; Buxner, Sanlyn

2018-01-01

The Quantitative Reasoning for College Science (QuaRCS) Assessment is a validated assessment instrument that was designed to measure changes in students' quantitative reasoning skills, attitudes toward mathematics, and ability to accurately assess their own quantitative abilities. It has been administered to more than 5,000 students at a variety of institutions at the start and end of a semester of general education college science instruction. I will begin by briefly summarizing our published work surrounding validation of the instrument and identification of underlying attitudinal factors (composite variables identified via factor analysis) that predict 50% of the variation in students' scores on the assessment. I will then discuss more recent unpublished work, including: (1) Development and validation of an abbreviated version of the assessment (The QuaRCS Light), which results in marked improvements in students' ability to maintain a high effort level throughout the assessment and has broad implications for quantitative reasoning assessments in general, and (2) Our efforts to revise the attitudinal portion of the assessment to better assess math anxiety level, another key factor in student performance on numerical assessments.

Seismic analysis of APR1400 RCS for site envelope using big mass method

International Nuclear Information System (INIS)

Kim, J. Y.; Jeon, J. H.; Lee, D. H.; Park, S. H.

2002-01-01

One of design concepts of APR1400 is the site envelope considering various soil sites as well as rock site. The KSNP's are constructed on the rock site where only the translational excitations are directly transferred to the plant. On the other hand, the rotational motions affect the responses of the structures in the soil cases. In this study, a Big Mass Method is used to consider rotational motions as excitations at the foundation in addition to translational ones to obtain seismic responses of the APR1400 RCS main components. The seismic analyses for the APR1400 excited simultaneously by translation and rotational motions were performed. The results show that the effect of soil sites is not significant for the design of main components and supports of the RCS, but it may be considerable for the design of reactor vessel internals, piping, and nozzles which have lower natural frequencies

A Study on Temperature Distribution in the Hot Leg Pipes considering the Variation of Flow Rate in RCS

Energy Technology Data Exchange (ETDEWEB)

Cho, Hyuksu; Yi, Kunwoo; Choe, Yoonjae; Jang, Hocheol; Yune, Seokjeong; Park, Seongchan [KEPCO Engineering and Construction, Daejeon (Korea, Republic of)

2016-10-15

In this study, a computational analysis is performed to predict the deviation in the temperature distribution in the hot leg pipe according to the flow rate variation in RCS. In the hot leg pipes of Reactor Coolant System (RCS) of APR1400, four Resistance Temperature Detectors (RTDs), to obtain the average hot leg temperature, are installed at each hot leg pipe (two in the upper region and the other two in the lower region around the wall of the hot leg pipe). There is a deviation in temperature distribution in the hot leg pipe due to the sudden changes in the flow direction and area from the reactor core exit to the hot leg pipe. The non-uniform temperature distribution in the hot leg pipe can affect the measurement of the plant parameters such as the reactor power and the reactor coolant flow rate. The following conclusions are reached 1) The non-uniform temperature distribution in the core exit is sustained to some extent through the entire region of hot leg pipe. 2) The temperature ranges having a uniform pattern are 45 - 120° and 240 - 315°. The sensor positions of RTDs are located in this interval (45 - 120° and 240 - 315°) and this sensor positions of RTDs show the appropriate temperature measurement. Also, the temperature distribution shows the similar pattern without reference to the flow rate variation in RCS.

Electrophysiological studies of the feasibility of suprachoroidal-transretinal stimulation for artificial vision in normal and RCS rats.

Science.gov (United States)

Kanda, Hiroyuki; Morimoto, Takeshi; Fujikado, Takashi; Tano, Yasuo; Fukuda, Yutaka; Sawai, Hajime

2004-02-01

Assessment of a novel method of retinal stimulation, known as suprachoroidal-transretinal stimulation (STS), which was designed to minimize insult to the retina by implantation of stimulating electrodes for artificial vision. In 17 normal hooded rats and 12 Royal College of Surgeons (RCS) rats, a small area of the retina was focally stimulated with electric currents through an anode placed on the fenestrated sclera and a cathode inserted into the vitreous chamber. Evoked potentials (EPs) in response to STS were recorded from the surface of the superior colliculus (SC) with a silver-ball electrode, and their physiological properties and localization were studied. In both normal and RCS rats, STS elicited triphasic EPs that were vastly diminished by changing polarity of stimulating electrodes and abolished by transecting the optic nerve. The threshold intensity (C) of the EP response to STS was approximately 7.2 +/- 2.8 nC in normal and 12.9 +/- 7.7 nC in RCS rats. The responses to minimal STS were localized in an area on the SC surface measuring 0.12 +/- 0.07 mm(2) in normal rats and 0.24 +/- 0.12 mm(2) in RCS rats. The responsive area corresponded retinotopically to the retinal region immediately beneath the anodic stimulating electrode. STS is less invasive in the retina than stimulation through epiretinal or subretinal implants. STS can generate focal excitation in retinal ganglion cells in normal animals and in those with degenerated photoreceptors, which suggests that this method of retinal stimulation is suitable for artificial vision.

Lazarus1, a DUF300 Protein, Contributes to Programmed Cell Death Associated with Arabidopsis acd11 and the Hypersensitive Response

DEFF Research Database (Denmark)

Malinovsky, F.G.; Brodersen, P.; Fiil, B.K.

2010-01-01

, here called lazarus (laz) mutants. In addition to known suppressors of R protein-mediated HR, we isolated 13 novel complementation groups of dominant and recessive laz mutants. Here we describe laz1, which encodes a protein with a domain of unknown function (DUF300), and demonstrate that LAZ1...

41 CFR 300-1.2 - What is the purpose of the FTR?

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What is the purpose of the FTR? 300-1.2 Section 300-1.2 Public Contracts and Property Management Federal Travel Regulation System GENERAL INTRODUCTION 1-THE FEDERAL TRAVEL REGULATION (FTR) § 300-1.2 What is the purpose of the...

Calculation of beam neutralization in the IPNS-Upgrade RCS

International Nuclear Information System (INIS)

Chae, Yong-Chul.

1995-01-01

The author calculated the neutralization of circulating beam in this report. In the calculation it is assumed that all electrons liberated from the background molecules due to the collisional processes are trapped in the potential well of the proton beam. Including the dependence of ionization cross sections on the kinetic energy of the incident particle, the author derived the empirical formula for beam neutralization as a function of time and baseline vacuum pressure, which is applicable to the one acceleration cycle of the IPNS-Upgrade RCS

Kvalitative Interviews med D&I Censorer, Undervisere, Kandidater og Studerende

DEFF Research Database (Denmark)

Brodersen, Søsser; Lindegaard, Hanne

2010-01-01

Som en opfølgning på telefon surveys blev der i tredje fase af D&I evalueringen gennemført en række kvalitative interviews med udvalgte censorer, undervisere, kandidater og studerende. Formålet med de kvalitative interviews har været at undersøge om: - D&I studerende og kandidater gennem forløbet i...

A comparison on radar range profiles between in-flight measurements and RCS-predictions

NARCIS (Netherlands)

Heiden, R. van der; Ewijk, L.J. van; Groen, F.C.A.

1998-01-01

The validation of Radar Cross Section (RCS) prediction techniques against real measurements is crucial to acquire confidence in predictions when measurements are nut available. In this paper we present the results of a comparison on one-dimensional signatures, i.e. radar range profiles. The profiles

Omsättning, rörelseresultat och kapitalstruktur – Påverkas företags kapitalstruktur av förändringar i dess omsättning eller rörelseresultat?

OpenAIRE

Lisstorp, Mattias; Steinberger, Paul

2012-01-01

Syftet med uppsatsen är att undersöka hur omsättning och rörelseresultat har samband med företagets kapitalstruktur. Resultaten jämförs med befintlig teori för att verifiera de teoretiska ansatserna. Regressionsanalys av tidsserier för 32 svenska börsnoterade företag med mer än 20 miljarder svenska kronor i omsättning 2010 har använts vid den här undersökningen. Data från åren 2004 till 2010 till varje företag är tagen från databasen ”Affärsdata” och undersöks genom regressionsanalys. Först u...

A Perspective on Reagent Diversity and Non-covalent Binding of Reactive Carbonyl Species (RCS and Effector Reagents in Non-enzymatic Glycation (NEG: Mechanistic Considerations and Implications for Future Research

Directory of Open Access Journals (Sweden)

Kenneth J. Rodnick

2017-06-01

Full Text Available This perspective focuses on illustrating the underappreciated connections between reactive carbonyl species (RCS, initial binding in the nonenzymatic glycation (NEG process, and nonenzymatic covalent protein modification (here termed NECPM. While glucose is the central species involved in NEG, recent studies indicate that the initially-bound glucose species in the NEG of human hemoglobin (HbA and human serum albumin (HSA are non-RCS ring-closed isomers. The ring-opened glucose, an RCS structure that reacts in the NEG process, is most likely generated from previously-bound ring-closed isomers undergoing concerted acid/base reactions while bound to protein. The generation of the glucose RCS can involve concomitantly-bound physiological species (e.g., inorganic phosphate, water, etc.; here termed effector reagents. Extant NEG schemes do not account for these recent findings. In addition, effector reagent reactions with glucose in the serum and erythrocyte cytosol can generate RCS (e.g., glyoxal, glyceraldehyde, etc.. Recent research has shown that these RCS covalently modify proteins in vivo via NECPM mechanisms. A general scheme that reflects both the reagent and mechanistic diversity that can lead to NEG and NECPM is presented here. A perspective that accounts for the relationships between RCS, NEG, and NECPM can facilitate the understanding of site selectivity, may help explain overall glycation rates, and may have implications for the clinical assessment/control of diabetes mellitus. In view of this perspective, concentrations of ribose, fructose, Pi, bicarbonate, counter ions, and the resulting RCS generated within intracellular and extracellular compartments may be of importance and of clinical relevance. Future research is also proposed.

Phosphorylation of p300 by ATM controls the stability of NBS1

International Nuclear Information System (INIS)

Jang, Eun Ryoung; Choi, Jae Duk; Jeong, Gajin; Lee, Jong-Soo

2010-01-01

Acetyltransferase, p300 is a transcriptional cofactor of signal-responsive transcriptional regulation. The surveillance kinase ataxia-telangiectasia mutated (ATM) plays a central role in regulation of a wide range of cellular DNA damage responses. Here, we investigated whether and how ATM mediates phosphorylation of p300 in response to DNA damage and how p300 phosphorylation is functionally linked to DNA damage. ATM-phosphorylated p300 in vitro and in vivo, in response to DNA damage. Phosphorylation of p300 proteins was observed upon γ-irradiation in ATM + cells but not ATM - cells. Importantly, expression of nonphosphorylatable serine to alanine form of p300 (S106A) destabilized both p300 and NBS1 proteins, after DNA damage. These data demonstrate that ATM transduces a DNA damage signal to p300, and that ATM-dependent phosphorylation of p300 is required for stabilization of NBS1 proteins in response to DNA damage.

Projekt Fodsår

DEFF Research Database (Denmark)

Kristensen, Inger Vestergaard; Scheving, Ulla; Mark, Edith

  Baggrund for projektet  Diabetespatienter med fodsår (ca. 85 nye pr. år) kommer med henblik på at få vurderet og behandlet deres fodsår. Der er læger og sygeplejersker fra specialområderne endokrinologi, ortopædkirurgi, karkirurgi samt fodterapeut og ortopædisk skomager involveret i denne konsu...

300-FF-1 remedial design report/remedial action work plan

Energy Technology Data Exchange (ETDEWEB)

Gustafson, F.W.

1997-02-01

The 300 Area has been divided into three operable units 300-FF-1, 300-FF-2, and 300-FF-5 all of which are in various stages of the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) process. The 300-FF-1 Operable Unit, the subject of this report, includes liquid waste disposal sites, landfills, and a burial ground. This Remedial Design Report/Remedial Action Work Plan (RDR/RAWP) provides a summary description of each waste site included in the 300-FF-1 Operable Unit, the basis for remedial actions to be taken, and the remedial action approach and management process for implementing these actions. The remedial action approach and management sections provide a description of the remedial action process description, the project schedule, the project team, required planning documentation, the remedial action change process, the process for verifying attainment of the remedial action goals, and the required CERCLA and RCRA closeout documentation. Appendix A provides additional details on each waste site. In addition to remediation of the waste sites, waste generated during the remedial investigation/feasibility study portions of the project will also be disposed at the Environmental Restoration Disposal Facility (ERDF). Appendix B provides a summary of the modeling performed in the 300-FF-1 Phase 3 FS and a description of the modeling effort to be used to show attainment of the remedial action goals. Appendix C provides the sampling and analysis plan (SAP) for all sampling and field-screening activities performed during remediation and for verification of attainment with the remedial action goals. Appendix D provides the public involvement plan, prepared to ensure information is provided to the public during remedial design and remedial action processes.

300-FF-1 remedial design report/remedial action work plan

International Nuclear Information System (INIS)

Gustafson, F.W.

1997-02-01

The 300 Area has been divided into three operable units 300-FF-1, 300-FF-2, and 300-FF-5 all of which are in various stages of the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) process. The 300-FF-1 Operable Unit, the subject of this report, includes liquid waste disposal sites, landfills, and a burial ground. This Remedial Design Report/Remedial Action Work Plan (RDR/RAWP) provides a summary description of each waste site included in the 300-FF-1 Operable Unit, the basis for remedial actions to be taken, and the remedial action approach and management process for implementing these actions. The remedial action approach and management sections provide a description of the remedial action process description, the project schedule, the project team, required planning documentation, the remedial action change process, the process for verifying attainment of the remedial action goals, and the required CERCLA and RCRA closeout documentation. Appendix A provides additional details on each waste site. In addition to remediation of the waste sites, waste generated during the remedial investigation/feasibility study portions of the project will also be disposed at the Environmental Restoration Disposal Facility (ERDF). Appendix B provides a summary of the modeling performed in the 300-FF-1 Phase 3 FS and a description of the modeling effort to be used to show attainment of the remedial action goals. Appendix C provides the sampling and analysis plan (SAP) for all sampling and field-screening activities performed during remediation and for verification of attainment with the remedial action goals. Appendix D provides the public involvement plan, prepared to ensure information is provided to the public during remedial design and remedial action processes

Der er faresignaler her - om ret og heuristik i det almindelige, kommunale tilsyn med børn og unge

DEFF Research Database (Denmark)

Svendsen, Idamarie Leth

2014-01-01

KORT RESUME Kommunerne underlægges i stigende grad krav om at føre et aktivt og opsøgende tilsyn med børn og unge. Kravene fremgår af serviceloven med tilhørende forskrifter. Disse regler har sammenhæng med en række andre regler på det sociale og velfærdsretlige område i øvrigt, men også med forv...

CLCA2 epigenetic regulation by CTBP1, HDACs, ZEB1, EP300 and miR-196b-5p impacts prostate cancer cell adhesion and EMT in metabolic syndrome disease.

Science.gov (United States)

Porretti, Juliana; Dalton, Guillermo N; Massillo, Cintia; Scalise, Georgina D; Farré, Paula L; Elble, Randolph; Gerez, Esther N; Accialini, Paula; Cabanillas, Ana M; Gardner, Kevin; De Luca, Paola; De Siervi, Adriana

2018-03-14

Prostate cancer (PCa) is the most common cancer among men. Metabolic syndrome (MeS) is associated with increased PCa aggressiveness and recurrence. Previously, we proposed C-terminal binding protein 1 (CTBP1), a transcriptional co-repressor, as a molecular link between these two conditions. Notably, CTBP1 depletion decreased PCa growth in MeS mice. The aim of this study was to investigate the molecular mechanisms that explain the link between MeS and PCa mediated by CTBP1. We found that CTBP1 repressed chloride channel accessory 2 (CLCA2) expression in prostate xenografts developed in MeS animals. CTBP1 bound to CLCA2 promoter and repressed its transcription and promoter activity in PCa cell lines. Furthermore, we found that CTBP1 formed a repressor complex with ZEB1, EP300 and HDACs that modulates the CLCA2 promoter activity. CLCA2 promoted PCa cell adhesion inhibiting epithelial-mesenchymal transition (EMT) and activating CTNNB1 together with epithelial marker (CDH1) induction, and mesenchymal markers (SNAI2 and TWIST1) repression. Moreover, CLCA2 depletion in PCa cells injected subcutaneously in MeS mice increased the circulating tumor cells foci compared to control. A microRNA (miRNA) expression microarray from PCa xenografts developed in MeS mice, showed 21 miRNAs modulated by CTBP1 involved in angiogenesis, extracellular matrix organization, focal adhesion and adherents junctions, among others. We found that miR-196b-5p directly targets CLCA2 by cloning CLCA2 3'UTR and performing reporter assays. Altogether, we identified a new molecular mechanism to explain PCa and MeS link based on CLCA2 repression by CTBP1 and miR-196b-5p molecules that might act as key factors in the progression onset of this disease. © 2018 UICC.

Optimering av nanocellulosa för tillämpning som papperstyrkeadditiv

OpenAIRE

Englöf, Johan

2015-01-01

Syftet med projektet var att undersöka hur homogeniserings förhållanden (tryck antal passager och därmed energiinsatsen) vid framställning av MFC (mikrofibrillär cellulosa), från enzymatiskt förbehandlade pappersmassafibrer påverkar hållfastheten av papper förstärkt med MFC. Arbetsgivaren för projektet var Innventia och det laborativa arbetet har utförts i deras lokaler. Fördelen med att använda MFC som tillsats i papper är att arket blir starkare [1]. Detta medför att en mindre mängd materia...

Long-term preservation of retinal function in the RCS rat model of retinitis pigmentosa following lentivirus-mediated gene therapy.

Science.gov (United States)

Tschernutter, M; Schlichtenbrede, F C; Howe, S; Balaggan, K S; Munro, P M; Bainbridge, J W B; Thrasher, A J; Smith, A J; Ali, R R

2005-04-01

The Royal College of Surgeons (RCS) rat is a well-characterized model of autosomal recessive retinitis pigmentosa (RP) due to a defect in the retinal pigment epithelium (RPE). It is homozygous for a null mutation in the gene encoding , a receptor tyrosine kinase found in RPE cells, that is required for phagocytosis of shed photoreceptor outer segments. The absence of Mertk results in accumulation of outer segment debris. This subsequently leads to progressive loss of photoreceptor cells. In order to evaluate the efficacy of lentiviral-mediated gene replacement therapy in the RCS rat, we produced recombinant VSV-G pseudotyped HIV-1-based lentiviruses containing a murine Mertk cDNA driven by a spleen focus forming virus (SFFV) promoter. The vector was subretinally injected into the right eye of 10-day-old RCS rats; the left eye was left untreated as an internal control. Here, we present a detailed assessment of the duration and extent of the morphological rescue and the resulting functional benefits. We examined animals at various time points over a period of 7 months by light and electron microscopy, and electroretinography. We observed correction of the phagocytic defect, slowing of photoreceptor cell loss and preservation of retinal function for up to 7 months. This study demonstrates the potential of gene therapy approaches for the treatment of retinal degenerations caused by defects specific to the RPE and supports the use of lentiviral vectors for the treatment of such disorders.

Regional cerebral blood flow and P300 in neurosurgical disorders

International Nuclear Information System (INIS)

Funahashi, Kazuyoshi; Hyoutani, Genhachi; Maeshima, Shinichirou; Miyamoto, Kazuki; Kuwata, Toshikazu; Terada, Tomoaki; Komai, Norihiko

1990-01-01

Changes in regional cerebral blood flow (rCBF), P300 and higher brain function were studied in neurosurgical patients with localized lesions on computed tomography (CT). Twenty-five patients ranging in age from 30 to 81 were studied. Nineteen of these suffered from cerebrovascular disease and six had tumors. Using the oddball paradigm, P300 components were elicited by rate tones (2 KHz) and recorded at Cz and Pz referred to linked ear-lobe electorodes. The P300 latencies of the patients were statistically compared with those of 27 normal subjects. Higher brain function was evaluated with the following psychological tests: a rating scale for psychological function (Sano and Tanemura), Mini-Mental State (MMS), Hasegawa's Dementia Scale (HDS) and the 'Kanahiroi' test. Regional CBF was measured in the bilateral cerebral cortices (the frontal, temporal and occipital lobes), thalamus and basal ganglia by means of a cold xenon CT method. The laterality indices of rCBF (Rt. rCBF/Lt. rCBF) in the bilateral symmetrical areas of the patients were compared to those of 8 normal subjects. Of the 25 patients, 12 revealed prolongation of P300 latency. Ten (86%) of the 12 with prolonged P300 latency showed reduction of rCBF in the right cerebral hemisphere (rt. frontal lobe, rt. thalamus and rt. basal ganglia). Significant correlations (P<0.025) were recognized between the P300 latencies and the laterality indices of rCBF in the frontal lobe and thalamus. There was a significant correlation (P<0.05) between the scores of MMS and HDS and the laterality indicies of rCBF in the frontal lobe only. In the 13 patients with normal P300 latency, 6 (46%) displayed no reduction in rCBF. The remaining 7 patients with normal P300 showed reduction of rCBF in the left hemisphere. Both right frontal lobe and right thalamus have an important role affecting the prolongation of P300 latency and disturbance of cognitive functions. (author)

Regulations, Codes, and Standards (RCS) Template for California Hydrogen Dispensing Stations

Energy Technology Data Exchange (ETDEWEB)

Rivkin, C.; Blake, C.; Burgess, R.; Buttner, W.; Post, M.

2012-11-01

This report explains the Regulations, Codes, and Standards (RCS) requirements for hydrogen dispensing stations in the State of California. The reports shows the basic components of a hydrogen dispensing station in a simple schematic drawing; the permits and approvals that would typically be required for the construction and operation of a hydrogen dispensing station; and a basic permit that might be employed by an Authority Having Jurisdiction (AHJ).

300-FF-1 remedial action sampling and analysis plan DQO process summary report

International Nuclear Information System (INIS)

Carlson, R.A.

1997-01-01

The scope of the 300-FF-1 Operable Unit (OU) data quality objective (DQO) process includes the soil and debris from the waste sites identified in the Proposed Plan for the 300-FF-1 and 300-FF-5 Operable units and, as the DQO process evolved, refined by the 300-FF-1 Record of Decision (ROD). Exclusions are identified in Section 1.3. The 300-FF-1 waste sites are addressed throughout the DQO process as they were subdivided in the proposed plan. The waste sites are divided into areas or zones known to be above the cleanup standards, zones below the cleanup standards, and zones where the contamination level is currently unknown. The project objectives are (1) to identify the criteria by which 300-FF-1 contaminated soil and debris may be shipped to the Environmental Restoration Disposal Facility (ERDF), (2) to identify the criteria by which the 300-FF-1 waste sites can be demonstrated as meeting the cleanup criteria, and (3) to develop a sampling and analysis plan (SAP) that adequately allows the evaluation of soil and debris analysis against the criteria

Sydkorea: Teknologiske tigerspring med globale udfordringer

DEFF Research Database (Denmark)

Brynskov, Martin

2010-01-01

Sydkorea har gennemgået en utrolig udvikling fra u-land til førende i-land i løbet af få årtier. Helt centralt står den teknologiske eksport af elektronik, biler og skibsbyggeri i verdenseliten. Men på trods af de mange succeser er der også udfordringer. Denne analyse viser – med aktuelle eksempl...

Soil washing physical separations test procedure - 300-FF-1 operable unit

Energy Technology Data Exchange (ETDEWEB)

Belden, R.D.

1993-10-08

This procedure provides the operations approach, a field sampling plan, and laboratory procedures for a soil washing test to be conducted by Alternative Remedial Technologies, Inc. (ART) in the 300-FF-1 area at the Hanford site. The {open_quotes}Quality Assurance Project Plan for the Soil Washing Physical Separations Test, 300-FF-1 Operable Unit,{close_quotes} Hanford, Washington, Alternative Remedial Technologies, Inc., February 1994 (QAPP) is provided in a separate document that presents the procedural and organizational guidelines for this test. This document describes specifications, responsibilities, and general procedures to be followed to conduct physical separation soil treatability tests in the North Process Pond of the 300-FF-1 Operable Unit (OU) at the Hanford Site. These procedures are based on the {open_quotes}300-FF-1 Physical Separations CERCLA Treatability Test Plan, DOE/RL 92-2l,{close_quotes} (DOE-RL 1993).

Soil washing physical separations test procedure - 300-FF-1 operable unit

International Nuclear Information System (INIS)

Belden, R.D.

1993-01-01

This procedure provides the operations approach, a field sampling plan, and laboratory procedures for a soil washing test to be conducted by Alternative Remedial Technologies, Inc. (ART) in the 300-FF-1 area at the Hanford site. The open-quotes Quality Assurance Project Plan for the Soil Washing Physical Separations Test, 300-FF-1 Operable Unit,close quotes Hanford, Washington, Alternative Remedial Technologies, Inc., February 1994 (QAPP) is provided in a separate document that presents the procedural and organizational guidelines for this test. This document describes specifications, responsibilities, and general procedures to be followed to conduct physical separation soil treatability tests in the North Process Pond of the 300-FF-1 Operable Unit (OU) at the Hanford Site. These procedures are based on the open-quotes 300-FF-1 Physical Separations CERCLA Treatability Test Plan, DOE/RL 92-2l,close quotes (DOE-RL 1993)

Nye integrerede ledelsesinformationssystemer SAP/R3

DEFF Research Database (Denmark)

Nielsen, Steen

1998-01-01

Artiklen beskriver og analyserer hovedindholdet i SAP/R3's controlling modul, speciel med sigte på hvilke forudsætninger systemet bygger på, dels med reference til den danske lønsomheds- og kapacitetsmodel.......Artiklen beskriver og analyserer hovedindholdet i SAP/R3's controlling modul, speciel med sigte på hvilke forudsætninger systemet bygger på, dels med reference til den danske lønsomheds- og kapacitetsmodel....

In situ degassing of the kicker magnet in J-PARC RCS

International Nuclear Information System (INIS)

Kamiya, Junichiro; Ogiwara, Norio; Hikichi, Yusuke; Yanagibashi, Toru; Kinsho, Michikazu

2015-01-01

The usual way to reduce outgassing from a device in vacuum is to heat up a whole vacuum chamber containing the device. However, the situation, where this method can be applied, is limited due to the heat expansion of the chamber. Especially in accelerators, where the vacuum chambers are connected with nearby beam pipes, this normal bake-out method may not be applied. If a heat source and heat shields are appropriately installed inside the chamber, heat flux is directed to the device. Therefore the device can be baked out without raising the temperature of the vacuum chamber. One candidate for such bake-out method to be applied is kicker magnets in J-PARC RCS, which are installed in large vacuum chambers. We performed the heating tests with some types of heaters in order to examine the effectiveness of this method and to decide the material and configuration of the heater. As a result, the graphite heater was selected for in-situ bake-out of the kickers in the RCS beam line. Using the method, the each material of kicker magnet was heated up above 100degC with keeping the temperature rise of the vacuum chamber below 30degC. (author)

Hvordan får man succes med Business Intelligence anvendt til data på danske universiteter?

DEFF Research Database (Denmark)

Gaardboe, Rikke; Nyvang, Tom; Jensen, Erling

brug, brugertilfredshed og individuel impact. 274 BI-brugere svarede på spørgeskemaet. Resultatet er at systemkvalitet og informationskvalitet er positiv og signifikant relateret til brugertilfredshed. Og brugertilfredsheden er positiv og signifikant med individual impact. Des højere systemkvalitet......, des mere bruger brugerne BI. Men brug af BI er ikke signifikant med individual impact. At den enkelte BI bruger oplever individual impact er ikke ensbetydende med organisatorisk impact. Derfor blev der gennemført 7 semi-strukturerede interviews. Formålet var at identificere den organisatoriske impact...

Ex-dagseffekten : Existerar överavkastningar på Stockholmsbörsen i samband med utdelningar?

OpenAIRE

Bäckman, Jacob; Strand, Magnus

2012-01-01

Denna studie har undersökt huruvida det är möjligt att på Nasdaq OMX Stockholm generera systematiska överavkastningar i samband med att aktier börjar handlas exklusive rätt till utdelningar. Samtliga utdelningstillfällen har undersökts under perioden 2007-2011 vilket givit en total observationsmängd på 699 stycken tillfällen. Genom att ha tagit hänsyn till eventuella marknadsfluktueringar och vikta dessa med bolagets unika risk, i form av betatal, har resultaten även justerats för normalavkas...

The Wheat Mediator Subunit TaMED25 Interacts with the Transcription Factor TaEIL1 to Negatively Regulate Disease Resistance against Powdery Mildew1

Science.gov (United States)

Zhang, Tianren; Jia, Jizeng; Sun, Jiaqiang

2016-01-01

Powdery mildew, caused by the biotrophic fungal pathogen Blumeria graminis f. sp. tritici, is a major limitation for the production of bread wheat (Triticum aestivum). However, to date, the transcriptional regulation of bread wheat defense against powdery mildew remains largely unknown. Here, we report the function and molecular mechanism of the bread wheat Mediator subunit 25 (TaMED25) in regulating the bread wheat immune response signaling pathway. Three homoalleles of TaMED25 from bread wheat were identified and mapped to chromosomes 5A, 5B, and 5D, respectively. We show that knockdown of TaMED25 by barley stripe mosaic virus-induced gene silencing reduced bread wheat susceptibility to the powdery mildew fungus during the compatible plant-pathogen interaction. Moreover, our results indicate that MED25 may play a conserved role in regulating bread wheat and barley (Hordeum vulgare) susceptibility to powdery mildew. Similarly, bread wheat ETHYLENE INSENSITIVE3-LIKE1 (TaEIL1), an ortholog of Arabidopsis (Arabidopsis thaliana) ETHYLENE INSENSITIVE3, negatively regulates bread wheat resistance against powdery mildew. Using various approaches, we demonstrate that the conserved activator-interacting domain of TaMED25 interacts physically with the separate amino- and carboxyl-terminal regions of TaEIL1, contributing to the transcriptional activation activity of TaEIL1. Furthermore, we show that TaMED25 and TaEIL1 synergistically activate ETHYLENE RESPONSE FACTOR1 (TaERF1) transcription to modulate bread wheat basal disease resistance to B. graminis f. sp. tritici by repressing the expression of pathogenesis-related genes and deterring the accumulation of reactive oxygen species. Collectively, we identify the TaMED25-TaEIL1-TaERF1 signaling module as a negative regulator of bread wheat resistance to powdery mildew. PMID:26813794

Advancing PubMed?

DEFF Research Database (Denmark)

Wildgaard, Lorna Elizabeth; Lund, Haakon

2016-01-01

the efficiency of biomedical literature searches. PubMed remains the primary resource for biomedical literature, and as PubMed makes the Medline data and Entrez PubMed Programming utilities freely available, any developer can produce alternative tools to search the database. The authors question if PubMed still...... provides the superior search interface for systematic searches or if the innovativeness of third-party tools provide alternatives worth considering. The paper aims to discuss these issues. Design/methodology/approach In all, 76 third-party tools that build on PubMed content were identified in a PubMed...... search and in published studies known to the authors. Only tools that provided free access to the broad PubMed content and designed specifically to enhance the search were included, reducing the set to 16 tools. The functionality of each tool within the scenario of a systematic search was compared across...

Projekt Frit Sind hjælper mennesker med social angst

DEFF Research Database (Denmark)

Moutamid, Mina El

2017-01-01

Social angst er en almindelig, men overset lidelse, som ofte er forbundet med isolation. Mange fortæller ikke om den angst, de oplever, til andre og kommer til at leve et liv med begrænsninger, som de kunne være foruden, hvis de fik hjælp. Angsten betyder også, at det kan være svært at komme...... hjemmefra og opsøge hjælp hos SIND eller andre rådgivninger. Frit Sind er et nyt tilbud i København til disse mennesker og har fokus på de specifikke behov, mennesker med social angst har....

Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats

Science.gov (United States)

Hou, Baoke; Fu, Yan; Weng, Chuanhuang; Liu, Weiping; Zhao, Congjian; Yin, Zheng Qin

2017-01-01

Rod-cone gap junctions open at night to allow rod signals to pass to cones and activate the cone-bipolar pathway. This enhances the ability to detect large, dim objects at night. This electrical synaptic switch is governed by the circadian clock and represents a novel form of homeostatic plasticity that regulates retinal excitability according to network activity. We used tracer labeling and ERG recording in the retinae of control and retinal degenerative dystrophic RCS rats. We found that in the control animals, rod-cone gap junction coupling was regulated by the circadian clock via the modulation of the phosphorylation of the melatonin synthetic enzyme arylalkylamine N-acetyltransferase (AANAT). However, in dystrophic RCS rats, AANAT was constitutively phosphorylated, causing rod-cone gap junctions to remain open. A further b/a-wave ratio analysis revealed that dystrophic RCS rats had stronger synaptic strength between photoreceptors and bipolar cells, possibly because rod-cone gap junctions remained open. This was despite the fact that a decrease was observed in the amplitude of both a- and b-waves as a result of the progressive loss of rods during early degenerative stages. These results suggest that electric synaptic strength is increased during the day to allow cone signals to pass to the remaining rods and to be propagated to rod bipolar cells, thereby partially compensating for the weak visual input caused by the loss of rods. PMID:28473754

Föräldrars upplevelse av insatsen föräldrakoordinator.

OpenAIRE

Aspén-Franzén, Annika

2014-01-01

Föräldrakoordination är en barnfokuserad alternativ konfliktlösningsmetod som praktiserats i Sverige sedan 2009. Denna intervjustudie har undersökt separerade föräldrars upplevelse av att få stöd i sitt föräldrasamarbete av en föräldrakoordinator. Intervjuer har genomförts med sju föräldrar som haft insatsen föräldrakoordinator under minst sex månader. Samtliga deltagande föräldrar har flera års erfarenhet av svårlösta konflikter med den andra föräldern och har tidigare provat andra former av...

Zaznana povezanost med komponentami zavarovalne storitve pri uporabnikih dopolnilnega zdravstvenega zavarovanja

OpenAIRE

Šebjan, Urban

2015-01-01

V prispevku proučujemo odnose med komponentami storitve dopolnilno prostovoljno zdravstveno zavarovanje (DPZZ), ki jim uporabniki pripisujejo različno vlogo. Raziskovalni model s štirimi konstrukti (pomembnost kakovosti, dodatnih kritij, cenovnih popustov storitve dpzz in ugleda zavarovalnice) in indikatorjem pomembnost zavarovalne premije dpzz smo preverili z modeliranjem strukturnih enačb (SEM) na vzorcu 300 slovenskih uporabnikov storitve DPZZ. Ugotovili smo, da se pomen komponente storitv...

Zaznana povezanost med komponentami zavarovalne storitve pri uporabnikih dopolnilnega zdravstvenega zavarovanja:

OpenAIRE

Šebjan, Urban

2013-01-01

V prispevku proučujemo odnose med komponentami storitve dopolnilno prostovoljno zdravstveno zavarovanje (DPZZ), ki jim uporabniki pripisujejo različno vlogo. Raziskovalni model s štirimi konstrukti (pomembnost kakovosti, dodatnih kritij, cenovnih popustov storitve dpzz in ugleda zavarovalnice) in indikatorjem pomembnost zavarovalne premije dpzz smo preverili z modeliranjem strukturnih enačb (SEM) na vzorcu 300 slovenskih uporabnikov storitve DPZZ. Ugotovili smo, da se pomen komponente storitv...

Error Analysis of Relative Calibration for RCS Measurement on Ground Plane Range

Directory of Open Access Journals (Sweden)

Wu Peng-fei

2012-03-01

Full Text Available Ground plane range is a kind of outdoor Radar Cross Section (RCS test range used for static measurement of full-size or scaled targets. Starting from the characteristics of ground plane range, the impact of environments on targets and calibrators is analyzed during calibration in the RCS measurements. The error of relative calibration produced by the different illumination of target and calibrator is studied. The relative calibration technique used in ground plane range is to place the calibrator on a fixed and auxiliary pylon somewhere between the radar and the target under test. By considering the effect of ground reflection and antenna pattern, the relationship between the magnitude of echoes and the position of calibrator is discussed. According to the different distances between the calibrator and target, the difference between free space and ground plane range is studied and the error of relative calibration is calculated. Numerical simulation results are presented with useful conclusions. The relative calibration error varies with the position of calibrator, frequency and antenna beam width. In most case, set calibrator close to the target may keep the error under control.

A novel mutation in MED12 causes FG syndrome (Opitz-Kaveggia syndrome)

NARCIS (Netherlands)

Rump, P.; Niessen, R. C.; Verbruggen, K. T.; Brouwer, O. F.; de Raad, M.; Hordijk, R.

Opitz-Kaveggia syndrome is a rare X-linked multiple congenital anomalies and intellectual disability disorder caused by the recurrent p.R961W mutation in the MED12 gene. Twenty-three affected males from 10 families with this mutation in the MED12 gene have been described so far. Here we report on a

Tidlige brukere av alkohol – hvem er de? Kjennetegn ved ungdom som starter tidlig med alkohol

Directory of Open Access Journals (Sweden)

Anders Grimsmo

2009-10-01

Full Text Available  SAMMENDRAGDebutalder med alkoholrus er en sterk prediktor for senere alkoholbruk. I denne undersøkelsen har visammenliknet de som starter med alkohol tidlig og før det er kulturelt akseptert, med ungdommenesom begynner i konfirmasjonsalder og de som utsetter alkoholdebuten. Vi finner at gruppen sombegynner tidlig ikke bare bryter de lokale tradisjonene for alkoholkonsum, men er i opposisjon tilnormer og autoriteter generelt. Alkohol er et positivt symbol for gruppen og det å ruse seg et ritualesom gir mening i deres miljø. Hjemmet står i den sterkeste posisjonen til å kunne utsette ungdommensalkoholdebut. Vi skisserer hvilke implikasjoner dette bør ha for strategien i det forebyggende arbeidet.

Observations of a cold front with strong vertical undulations during the ARM RCS-IOP

Energy Technology Data Exchange (ETDEWEB)

Starr, D.O`C.; Whiteman, D.N. [Goddard Space Flight Center, Greenbelt, MD (United States); Melfi, S.H. [Univ. of Maryland, Baltimore, MD (United States)] [and others

1996-04-01

Passage of a cold front was observed on the night of April 14-15, 1994, during the Atmospheric Radiation Measurement (ARM) Remote Cloud Sensing (RCS) Intensive Observatios Period (IOP) at the Southern Great Plains Cloud and Radiation Testbed (CART) site near Lamont, Oklahoma. The observations are described.

Tosprogede børns møde med metafiktion i en postmoderne billedbog

DEFF Research Database (Denmark)

Daugaard, Line Møller; Johansen, Martin Blok

2012-01-01

casestudium af tosprogede børns møde med en postmoderne billedbog med tydelige metafiktive træk. I vandringerne gennem bogen demonstrerer mange tosprogede børn en høj grad af litterær kompetence. De omgås bogens metafiktive træk med stor faglig sikkerhed og efterspørger bøger, som udfordrer dem og bryder med...... deres forventninger som læsere. På den baggrund opfordres der til, at postmoderne billedbøger udgør en del af tilbuddet til tosprogede børn. When teachers and school librarians choose picture books for bilingual children, they often base their choice on an evaluation of linguistic comprehensibility...... of the bilingual children demonstrate a high level of literary competence. They deal with the book’s metafictional features with great confidence and explicitly call for books which challenge them and break with their expectations as readers. Consequently, it is argued that postmodern picture books should be part...

Evaluation of a coolant injection into the in-vessel with a RCS depressurization by using SCDAP/RELAP5

International Nuclear Information System (INIS)

Rae-Joon, Park; Sang-Baik, Kim; Hee-Dong, Kim

2007-01-01

As part of the evaluations of a severe accident management strategy, a coolant injection in the vessel with a reactor coolant system (RCS) depressurization has been evaluated by using the SCDAP/RELAP5 computer code. Two high pressure sequences of a small break loss of coolant accident (LOCA) without safety injection (SI) and a total loss of feed water (LOFW) accident have been analyzed in optimized power reactor OPR-1000. The SCDAP/RELAP5 results have shown that only one train operation of a high pressure safety injection at 30,000 seconds with a RCS depressurization by using one condenser dump valve at 6 minutes after an entrance of the severe accident management guidance prevents a reactor vessel failure for the small break LOCA without SI. In this case, only train operation of the low pressure safety injection (LPSI) without the high pressure safety injection (HPSI) does not prevent a reactor vessel failure. Only one train operation of the HPSI at 20,208 seconds with a RCS depressurization by using two safety depressurization system valves at 40 minutes after an initial opening of the safety relief valve prevents a reactor vessel failure for the total LOFW. (authors)

Jokar et al., Afr J Tradit Complement Altern Med. (2016) 13(1):40-44 ...

African Journals Online (AJOL)

PROF ADEWUNMI

Jokar et al., Afr J Tradit Complement Altern Med. ... Shiraz- Iran.3Department of Obstetrics and Gynecology, School of Medicine and maternal- fetal ..... Ann Intern Med 2001; 135(5):344–51. 7. ... Clin Geriatr Med.2008; ... Indian J. Med Res.

Early Start Denver Model - intervention for de helt små børn med autisme

DEFF Research Database (Denmark)

Brynskov, Cecilia

2015-01-01

Early Start Denver Model (ESDM) er en autismespecifik interventionsmetode, som er udviklet til helt små børn med autisme (0-4 år). Metoden fokuserer på at styrke den tidlige kontakt og barnets motivation, og den arbejder målrettet med de socio-kommunikative forløbere for sprog og med den tidlige...

Disrupt dit Mindset og få succes med Big Data

DEFF Research Database (Denmark)

Rydén, Pernille; Ringberg, Torsten; Østergaard Jacobsen, Per

Organisationer fokuserer i stigende grad på, hvordan de kan bruge Big Data strategisk. De investerer milliarder af kroner i denne ny teknologi, men værdien og afkastet viser sig tit at være begrænset. Sådanne udfordringer kan meget vel skyldes ledernes mindset, der begrænser hvordan organisationen...... bruger Big Data-teknologi til at styrke interaktionen og samspillet med kunder og andre interessenter. Det første skridt på vejen mod at få succes med Big Data er derfor at identificere og udfordre sit ledelsesmæssige mindset. I denne bog identificerer og diskuterer vi fire dominerende ledelsesmæssige...... mindset, der hver især fører til fire unikke Big Data strategier. Når ledere inden for samme team har forskellige mindset, kan det føre til manglende mental og organisatorisk alignment og problemer med at håndtere disruption. Da mindsets ofte er ubevidste, har vi udviklet en onlinetest, der hjælper dig og...

For eller imod vaccination? Om forældres beslutningstagen I forbindelse med Calmette-vaccination af deres nyfødte barn

DEFF Research Database (Denmark)

Thybo Pihl, Gitte

Sygehus, Rigshospitalet og Hvidovre Hospital, fra oktober 2012 til november 2013. I alt 4184 familier blev randomiseret i Calmette-studiet. Ad formål 1: Før Calmette-studiets begyndelse blev fem fokusgrupper gennemført med formålet at undersøge forældres overvejelser, når de skal tage stilling til, om...... Kolding blev efterfølgende telefon-interviewet med en dansk valideret udgave af "The Decisional Conflict Scale" med det formål at undersøge, hvor trygge de var ved beslutningen og om socio-demografiske faktorer havde betydning for deres oplevelse af tvivl. Ad formål 3: Spørgsmål om forældres...... kvantitativ metode, idet der anvendes statistiske tests af socio-demografiske faktorers betydning for The Decisional Conflict Score, ligesom selve scoren opgøres statistisk. Formål 3 er undersøgt i et miks af statistiske opgørelser af svarene fra telefon-interview kombineret med uddybende perspektiver fra...

Gruppemusikterapi med patienter med borderline-personlighedsforstyrrelse i dagbehandlingsregi

DEFF Research Database (Denmark)

Hannibal, Niels

2008-01-01

Denne artikel er første redegørelse for de erfaringer, som er gjort med gruppemusikterapi (GMT) for patienter med borderline-personlighedsforstyrrelse (BPF) i dagbehandlingsregi på Aalborg Psykiatriske Sygehus. Artiklen indeholder både konkrete anvisninger til aktiviteter og interventioner, liges...

Udvikling af dialogisk kompetence hos børn med CI

DEFF Research Database (Denmark)

Dammeyer, Jesper Herup; Carstensen, Susanne; Karlshøj, Bente

2011-01-01

Der er relativ god viden om børn med CI’s sproglige udvikling, hvad angår sproglyde og ord. Derimod er der i den internationale forskning kun beskrevet meget lidt om den del af den sproglige udvikling, som ligger ud over sætningsniveauet. Denne artikel beskriver nogle af de resultater, der er...... fremkommet ved et fire år langt følgestudie af tre førskolebørn med CI. Børnenes sproglige udvikling er observeret og analyseret i forhold til dialogiske kompetencer. Resultaterne peger på, at børnene udvikler gode talesproglige kompetencer i løbet af den fireårige periode, men at børnene har brug for støtte...

Lederudvikling med mål og retning

DEFF Research Database (Denmark)

Brix, Jacob

2010-01-01

Altid et behov for udvikling Vi stopper aldrig med at udvikle os; og hvis vi gør, så fortsætter samfundet sin udvikling. At være leder i år 2010 er ikke det samme som at være leder i 1954, og ledelse i år 2025 er helt sikkert ikke det samme som ledelse i dag. Henry Mintzberg, en meget anerkendt...... canadisk organisations og ledelsesforsker, er kendt for at sige: "you can't create a leader in a classroom!" - som frit tolket betyder: man bliver ikke leder på skolebænken. Mintzberg mener at en rigtig leder først skabes, når vedkommende har praksiserfaring og derefter søger videreuddannelse. For én ting...

Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism.

Science.gov (United States)

Fu, Maofu; Wang, Chenguang; Rao, Mahadev; Wu, Xiaofang; Bouras, Toula; Zhang, Xueping; Li, Zhiping; Jiao, Xuanmao; Yang, Jianguo; Li, Anping; Perkins, Neil D; Thimmapaya, Bayar; Kung, Andrew L; Munoz, Alberto; Giordano, Antonio; Lisanti, Michael P; Pestell, Richard G

2005-08-19

Cyclin D1 encodes a regulatory subunit, which with its cyclin-dependent kinase (Cdk)-binding partner forms a holoenzyme that phosphorylates and inactivates the retinoblastoma protein. In addition to its Cdk binding-dependent functions, cyclin D1 regulates cellular differentiation in part by modifying several transcription factors and nuclear receptors. The molecular mechanism through which cyclin D1 regulates the function of transcription factors involved in cellular differentiation remains to be clarified. The histone acetyltransferase protein p300 is a co-integrator required for regulation of multiple transcription factors. Here we show that cyclin D1 physically interacts with p300 and represses p300 transactivation. We demonstrated further that the interaction of the two proteins occurs at the peroxisome proliferator-activated receptor gamma-responsive element of the lipoprotein lipase promoter in the context of the local chromatin structure. We have mapped the domains in p300 and cyclin D1 involved in this interaction. The bromo domain and cysteine- and histidine-rich domains of p300 were required for repression by cyclin D1. Cyclin D1 repression of p300 was independent of the Cdk- and retinoblastoma protein-binding domains of cyclin D1. Cyclin D1 inhibits histone acetyltransferase activity of p300 in vitro. Microarray analysis identified a signature of genes repressed by cyclin D1 and induced by p300 that promotes cellular differentiation and induces cell cycle arrest. Together, our results suggest that cyclin D1 plays an important role in cellular proliferation and differentiation through regulation of p300.

PubMedReco: A Real-Time Recommender System for PubMed Citations.

Science.gov (United States)

Samuel, Hamman W; Zaïane, Osmar R

2017-01-01

We present a recommender system, PubMedReco, for real-time suggestions of medical articles from PubMed, a database of over 23 million medical citations. PubMedReco can recommend medical article citations while users are conversing in a synchronous communication environment such as a chat room. Normally, users would have to leave their chat interface to open a new web browser window, and formulate an appropriate search query to retrieve relevant results. PubMedReco automatically generates the search query and shows relevant citations within the same integrated user interface. PubMedReco analyzes relevant keywords associated with the conversation and uses them to search for relevant citations using the PubMed E-utilities programming interface. Our contributions include improvements to the user experience for searching PubMed from within health forums and chat rooms, and a machine learning model for identifying relevant keywords. We demonstrate the feasibility of PubMedReco using BMJ's Doc2Doc forum discussions.

Remedial action and waste disposal project -- 300-FF-1 remedial action readiness assessment plan

International Nuclear Information System (INIS)

April, J.G.; Carlson, R.A.; Greif, A.A.; Johnson, C.R.; Orewiler, R.I.; Perry, D.M.; Plastino, J.C.; Roeck, F.V.; Tuttle, B.G.

1997-04-01

This Readiness Assessment Plan presents the methodology used to assess the readiness of the 300-FF-1 Remedial Action Project. Remediation involves the excavation, treatment if applicable, and final disposal of contaminated soil and debris associated with the waste sites in the 300-FF-1 Operable Unit. The scope of the 300-FF-1 remediation is to excavate, transport, and dispose of contaminated solid from sites identified in the 300-FF-1 Operable Unit

Environmental Control Plan for the 300-FF-1 Operable Unit Remedial Action

International Nuclear Information System (INIS)

Carlson, R.A.

2000-01-01

This environmental control plan is for the 300-FF-1 Operable Unit Remedial Action Project. The purpose of this plan is to identify environmental requirements for the 300-FF-1 operable unit Remedial Action/Waste Disposal Project

Diabetes mellitus type 1

OpenAIRE

Tøraasen, Lisa Vangen; Al-Sultan, Zainab

2014-01-01

Bacheloroppgave i sykepleie, 2014 Hvert år blir rundt 600 nordmenn diagnostisert med sykdommen diabetes type 1, og Norge er et av landene i verden med størst andel av barnediabetes. I dag er det 15 000- 20 000 personer i Norge som har diabetes type 1, og antall barn som får diabetes har fordoblet seg de siste 30 årene (Diabetesforbundet, 2014). Problemstillingen vår gikk ut på hvordan sykepleiere kan veilede og undervise ungdom med nyoppdaget diabetes type på sykehus. Ut i fra litteraturst...

Diabetes mellitus type 1

OpenAIRE

Tøraasen, Lisa Vangen; Al-Sultan, Zainab

2014-01-01

Hvert år blir rundt 600 nordmenn diagnostisert med sykdommen diabetes type 1, og Norge er et av landene i verden med størst andel av barnediabetes. I dag er det 15 000- 20 000 personer i Norge som har diabetes type 1, og antall barn som får diabetes har fordoblet seg de siste 30 årene (Diabetesforbundet, 2014). Problemstillingen vår gikk ut på hvordan sykepleiere kan veilede og undervise ungdom med nyoppdaget diabetes type på sykehus. Ut i fra litteraturstudiet har vi arbeidet oss frem for å ...

Trafikulykker med ældre bilister - litteraturundersøgelse

DEFF Research Database (Denmark)

Siren, Anu Kristiina

Andelen af ældre mennesker er i disse år hastigt stigende i de industrialiserede lande, herunder i Danmark. Som følge heraf vokser antallet af ældre bilister, og nutidens ældre forbliver aktive og mobile langt op i årene. Da mobilitet er en vigtig del af dagligdagen, skal transportsystemet blandt...... antal ældre trafikanter vil medføre flere sikkerhedsmæssige problemer. Tværtimod ser det ud, som om sikkerheden generelt vil øges i takt med det voksende antal ældre trafikanter. Denne positive udvikling er dog ikke ensbetydende med, at der ikke fortsat skal fokuseres på ældrevenlige løsninger i...

Seismic analysis of the reactor coolant system of PWR nuclear power plants

International Nuclear Information System (INIS)

Borsoi, L.; Sollogoub, P.

1986-01-01

For safety considerations, seismic analyses are performed of the Reactor Coolant System (R.C.S.) of PWR Plants. After a brief description of the R.C.S. and R.C.S. operation, the paper presents the two types of analysis used to determine the effect of earthquake on the R.C.S.: modal spectral analysis and nonlinear time history analysis. The paper finally shows how seismic loadings are combined with other types of loadings and illustrates how the consideration of seismic loads affects R.C.S. design [fr

Development of Probability Evaluation Methodology for High Pressure/Temperature Gas Induced RCS Boundary Failure and SG Creep Rupture

Energy Technology Data Exchange (ETDEWEB)

Lee, Byung Chul; Hong, Soon Joon; Lee, Jin Yong; Lee, Kyung Jin; Lee, Kuh Hyung [FNC Tech. Co., Seoul (Korea, Republic of)

2008-04-15

Existing MELCOR 1.8.5 model was improved in view of severe accident natural circulation and MELCOR 1.8.6 input model was developed and calculation sheets for detailed MELCOR 1.8.6 model were produced. Effects of natural circulation modeling were found by simulating SBO accident by comparing existing model with detailed model. Major phenomenon and system operations which affect on natural circulation by high temperature and high pressure gas were investigated and representative accident sequences for creep rupture model of RCS pipeline and SG tube were selected.

Indsats for forældre til børn med ADHD

DEFF Research Database (Denmark)

Neubert, Katja

2012-01-01

Et nyt review, udarbejdet af forskergruppen omkring Morris Zwi, undersøger om interventionsprogrammer til forældre til børn med ADHD er effektive, når det gælder reducering af børnenes ADHD-relaterede adfærd og associerede problemer som eksempelvis indlæringsproblemer. Reviewet peger på, at en...... indsats til forældre til børn med ADHD kan have en gavnlig effekt på børnenes adfærd. Interventionen kan også være med til at sænke stressniveauet hos forældre til disse børn, og forbedre forældrenes selvtillid....

ZEB1 Mediates Drug Resistance and EMT in p300-Deficient CRC.

Science.gov (United States)

Lazarova, Darina; Bordonaro, Michael

2017-01-01

We discuss the hypothesis that ZEB1-Wnt-p300 signaling integrates epithelial to mesenchymal transition (EMT) and resistance to histone deacetylase inhibitors (HDACis) in colorectal cancer (CRC) cells. The HDACi butyrate, derived from dietary fiber, has been linked to CRC prevention, and other HDACis have been proposed as therapeutic agents against CRC. We have previously discussed that resistance to butyrate likely contributes to colonic carcinogenesis, and we have demonstrated that butyrate resistance leads to cross-resistance to cancer therapeutic HDACis. Deregulated Wnt signaling is the major initiating event in most CRC cases. One mechanism whereby butyrate and other HDACis exert their anti-CRC effects is via Wnt signaling hyperactivation, which promotes CRC cell apoptosis. The histone acetylases (HATs) CBP and p300 are mediators of Wnt transcriptional activity, and play divergent roles in the downstream consequences of Wnt signaling. CBP-mediated Wnt signaling is associated with cell proliferation and stem cell maintenance; whereas, p300-mediated Wnt activity is associated with differentiation. We have found that CBP and p300 differentially affect the ability of butyrate to influence Wnt signaling, apoptosis, and proliferation. ZEB 1 is a Wnt signaling-targeted gene, whose product is a transcription factor expressed at the invasive front of carcinomas where it promotes malignant progression and EMT. ZEB1 is typically a transcriptional repressor; however, when associated with p300, ZEB1 enhances transcription. These changes in ZEB1 activity likely affect the cancer cell phenotype. ZEB1 has been shown to promote resistance to chemotherapeutic agents, and expression of ZEB1 is upregulated in butyrate-resistant CRC cells that lack p300 expression. Since the expression of ZEB1 correlates with poor outcomes in cancer, ZEB represents a relevant therapeutic target. Here we propose that targeting the signaling network established by ZEB1, Wnt signaling, and p300

Localization and Developmental Expression Patterns of CSPG in the RCS Rat Retina

Directory of Open Access Journals (Sweden)

Li-Feng Chen

2011-05-01

Full Text Available Purpose: Investigate changes in chondroitin sulfate proteoglycan (CSPG distribution in Royal College of Surgeons (RCS rat retinae. Could CSPGs distribution act as a physical barrier to transplanted cell migration in degenerating retinae? Methods: CSPG expression was examined in RCS and Long-Evans rat retinae from birth to postnatal day 150 (PND150 using immunofluorescence and western-blots. Results: Both groups showed a rapid rise in CSPG expression on PND14, which peaked on PND21 before declining to lower levels by PND35. CSPG expression had risen again by PND90 and remained elevated for the duration of the study (PND150. However, from PND21, CSPG expression was significantly higher (p ≤ 0.05, n = 5 in Long-Evans rat retinae. CSPG-positive cells were localized in the ganglion cell layer (GCL and the photoreceptor outer segment debris zone (DZ; CSPG expression in the DZ was the main contributor to the higher expression in older animals for both groups. Conclusions: Increased expression of CSPGs in the DZ may act as a physical barrier following retinal cellular transplantation. CSPGs in the GCL is probably related to dendritic changes. CSPG accumulation in the older retinae suggests that aging influences the microenvironment in the retina, which may affect the efficacy of cell transplantation.

Possible sources of neuroprotection following subretinal silicon chip implantation in RCS rats

Science.gov (United States)

Pardue, Machelle T.; Phillips, Michael J.; Yin, Hang; Fernandes, Alcides; Cheng, Yian; Chow, Alan Y.; Ball, Sherry L.

2005-03-01

Current retinal prosthetics are designed to stimulate existing neural circuits in diseased retinas to create a visual signal. However, implantation of retinal prosthetics may create a neurotrophic environment that also leads to improvements in visual function. Possible sources of increased neuroprotective effects on the retina may arise from electrical activity generated by the prosthetic, mechanical injury due to surgical implantation, and/or presence of a chronic foreign body. This study evaluates these three neuroprotective sources by implanting Royal College of Surgeons (RCS) rats, a model of retinitis pigmentosa, with a subretinal implant at an early stage of photoreceptor degeneration. Treatment groups included rats implanted with active and inactive devices, as well as sham-operated. These groups were compared to unoperated controls. Evaluation of retinal function throughout an 18 week post-implantation period demonstrated transient functional improvements in eyes implanted with an inactive device at 6, 12 and 14 weeks post-implantation. However, the number of photoreceptors located directly over or around the implant or sham incision was significantly increased in eyes implanted with an active or inactive device or sham-operated. These results indicate that in the RCS rat localized neuroprotection of photoreceptors from mechanical injury or a chronic foreign body may provide similar results to subretinal electrical stimulation at the current output evaluated here.

P/B i kombination med marknadsvärde : En studie på Stockholmsbörsen 2006 - 2016

OpenAIRE

Lundgren, Anton; Ahlgren, Sara

2017-01-01

Bakgrund: Denna studie är ett test av investeringsstrategi baserad på relativvärdering av multiplar. Den multipel som kommer att studeras som investeringsstrategi är Price-to-Book (P/B). Valet av multipel på P/B beror på att det är en väl omskriven multipel som fortfarande väcker frågeställningar avseende betydelsen av bokfört värde i kombination med marknadsvärde. Syfte: Syftet med denna studie är att undersöka och analysera multipeln P/B som investeringsstrategi för aktier. Vidare syftar st...

Med hjerne og hjerte - et aktionsforskningsprojekt om demensomsorg

DEFF Research Database (Denmark)

Hansen, Helle Krogh; Rasmussen, Else Marie

om værdier; individuelle interviews (8 pårørende og 3 frivillige); to kernekvalitetsundersøgelser (4 medarbejdere undersøgte kvaliteter og værdier ud fra D. Ofmans teori om kernekvaliteter); en kernekvalitetsundersøgelse i samarbejde med lederen; SWOT-analyser, udarbejdelse og analyse af...

MED23-associated intellectual disability in a non-consanguineous family.

Science.gov (United States)

Trehan, Aditi; Brady, Jacqueline M; Maduro, Valerie; Bone, William P; Huang, Yan; Golas, Gretchen A; Kane, Megan S; Lee, Paul R; Thurm, Audrey; Gropman, Andrea L; Paul, Scott M; Vezina, Gilbert; Markello, Thomas C; Gahl, William A; Boerkoel, Cornelius F; Tifft, Cynthia J

2015-06-01

Intellectual disability (ID) is a heterogeneous condition arising from a variety of environmental and genetic factors. Among these causes are defects in transcriptional regulators. Herein, we report on two brothers in a nonconsanguineous family with novel compound heterozygous, disease-segregating mutations (NM_015979.3: [3656A > G];[4006C > T], NP_057063.2: [H1219R];[R1336X]) in MED23. This gene encodes a subunit of the Mediator complex that modulates the expression of RNA polymerase II-dependent genes. These brothers, who had profound ID, spasticity, congenital heart disease, brain abnormalities, and atypical electroencephalography, represent the first case of MED23-associated ID in a non-consanguineous family. They also expand upon the clinical features previously reported for mutations in this gene. © 2015 Wiley Periodicals, Inc.

Dynamisk Ledarutveckling : En ny metod för personlig utveckling av ledare skapad genom integration av två etablerade metoder för personlig utveckling

OpenAIRE

Rudbäck, Marie-Christine

2013-01-01

Syftet med denna studie är att teoretiskt pröva att integrera en etablerad metod för personlig utveckling, The Skilled Helper, med metoden Dynamisk Pedagogik och skapa en ny metod för en specifik tillämpning, personlig utveckling av ledare. Integrationen görs med hjälp av en etablerad metametod för metodutveckling. De bägge ingående metoderna värderas enligt fastställda kriterier. Samma kriterier används sedan för att värdera den nya metod som designas. Med detta har studien uppnått en jämför...

Metabolic patterns of JWH-210, RCS-4, and THC in pig urine elucidated using LC-HR-MS/MS: Do they reflect patterns in humans?

Science.gov (United States)

Schaefer, Nadine; Helfer, Andreas G; Kettner, Mattias; Laschke, Matthias W; Schlote, Julia; Ewald, Andreas H; Meyer, Markus R; Menger, Michael D; Maurer, Hans H; Schmidt, Peter H

2017-04-01

The knowledge of pharmacokinetic (PK) properties of synthetic cannabinoids (SCs) is important for interpretation of analytical results found for example in intoxicated individuals. In the absence of human data from controlled studies, animal models elucidating SC PK have to be established. Pigs providing large biofluid sample volumes were tested for prediction of human PK data. In this context, the metabolic fate of two model SCs, namely 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-210) and 2-(4-methoxyphenyl)-1-(1-pentyl-indol-3-yl)methanone (RCS-4), was elucidated in addition to Δ 9 -tetrahydrocannabinol (THC). After intravenous administration of the compounds, hourly collected pig urine was analyzed by liquid chromatography-high resolution mass spectrometry. The following pathways were observed: for JWH-210, hydroxylation at the ethyl side chain or pentyl chain and combinations of them followed by glucuronidation; for RCS-4, hydroxylation at the methoxyphenyl moiety or pentyl chain followed by glucuronidation as well as O-demethylation followed by glucuronidation or sulfation; for THC, THC glucuronidation, 11-hydroxylation, followed by carboxylation and glucuronidation. For both SCs, parent compounds could not be detected in urine in contrast to THC. These results were consistent with those obtained from human hepatocyte and/or human case studies. Urinary markers for the consumption of JWH-210 were the glucuronide of the N-hydroxypentyl metabolite (detectable for 3-4 h) and of RCS-4 the glucuronides of the N-hydroxypentyl, hydroxy-methoxyphenyl (detectable for at least 6 h), and the O-demethyl-hydroxy metabolites (detectable for 4 h). Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Att veta när man ska göra det man vet att man ska göra : om barn med ADHD, uppfattning av tid och att komma ihåg att göra det man har planerat

OpenAIRE

Hillertz, Anna

2005-01-01

I den här studien undersöks om det är bristande tidsuppfattning som orsakar sämre prospektivt minne hos barn med diagnos ADHD. Studien syftar även till att utreda vad prospektivt minne har för relation till arbetsminne och exekutiva funktioner. Studien har genomförts genom att två grupper, en grupp barn med diagnos ADHD och en kontrollgrupp, har utfört uppgifter som ger mått på prospektivt minne, tidsuppfattning, arbetsminne och exekutiva funktioner. Barnen i ADHD-gruppen har även deltagit i ...

Hvad ved Herbener om det moderne Europas rødder?

DEFF Research Database (Denmark)

Thomassen, Bjørn

2016-01-01

I FORBINDELSE MED den nyligt udgivne samtalebog med og om dronning Margrethe - ' De dybeste rødder' - fremførte religionshistoriker Jens-André P.......I FORBINDELSE MED den nyligt udgivne samtalebog med og om dronning Margrethe - ' De dybeste rødder' - fremførte religionshistoriker Jens-André P....

A muscle-specific knockout implicates nuclear receptor coactivator MED1 in the regulation of glucose and energy metabolism.

Science.gov (United States)

Chen, Wei; Zhang, Xiaoting; Birsoy, Kivanc; Roeder, Robert G

2010-06-01

As conventional transcriptional factors that are activated in diverse signaling pathways, nuclear receptors play important roles in many physiological processes that include energy homeostasis. The MED1 subunit of the Mediator coactivator complex plays a broad role in nuclear receptor-mediated transcription by anchoring the Mediator complex to diverse promoter-bound nuclear receptors. Given the significant role of skeletal muscle, in part through the action of nuclear receptors, in glucose and fatty acid metabolism, we generated skeletal muscle-specific Med1 knockout mice. Importantly, these mice show enhanced insulin sensitivity and improved glucose tolerance as well as resistance to high-fat diet-induced obesity. Furthermore, the white muscle of these mice exhibits increased mitochondrial density and expression of genes specific to type I and type IIA fibers, indicating a fast-to-slow fiber switch, as well as markedly increased expression of the brown adipose tissue-specific UCP-1 and Cidea genes that are involved in respiratory uncoupling. These dramatic results implicate MED1 as a powerful suppressor in skeletal muscle of genetic programs implicated in energy expenditure and raise the significant possibility of therapeutical approaches for metabolic syndromes and muscle diseases through modulation of MED1-nuclear receptor interactions.

Standard reference and other important nuclear data. Supplement 1 to the report BNL-NCS-51123 (Dec. 1979) = ENDF-300 = IAEA-NDS-15/300 (microfiche)

Energy Technology Data Exchange (ETDEWEB)

Bhat, M R [ed.

1981-03-01

The document contains inserts to be added to the report `Standard Reference and Other Important Nuclear Data` (BNL-NCS-51123, ENDF-300), including the following two articles: Fast Neutron Capture in {sup 238}U and {sup 232}Th by W.P. Poentiz (ANL), and {sup 239}Pu Decay Power Discrepancy by T.R. England and P.G. Young (LANL) Refs, figs

Initial mass function in R-associations CMaR1, Mon R1 and Mon R2 from radiodata

International Nuclear Information System (INIS)

Pyatunina, T.B.

1985-01-01

Results of search for compact radiosources in R-associations CMa R1 and Mon R1 carried out with the radiotelescope RATAN-600 at the 7.6-cm wavelength are given. The number of sources found in the association Mon R1 is approximately equal to the expected number of background extragalactic radiosources. In the association CMa R1 seven radiosources of small angular diameter with the flux greater than 30 mJy are found, two of which probably are background sources. A comparison of optical and radiodata on the association CMa R1 and previously published data on the association Mon R2 make it possible to estimate the initial mass function for associations under study: xi(M) infinity Msup(-2.7+-0.7) for stars with M approximately 10Msub(Sun)

Apport diagnostique de la cervicotomie exploratrice: étude rétrospective de 300 cas

Science.gov (United States)

Darouassi, Youssef; Chihani, Mehdi; Touati, Mohamed Mliha; Ammar, Haddou; Bouaity, Brahim

2015-01-01

Les tuméfactions cervicales représentent un motif fréquent de consultation, et les adénopathies en constituent l’étiologie la plus fréquente. L'examen clinique et les bilans paracliniques permettent, dans la majorité des cas de retrouver une étiologie. Néanmoins certaines de ces tuméfactions restent d'origine non précisée, portant donc l'indication d'une cervicotomie exploratrice. Il s'agit d'une étude rétrospective d'une série de 300 cas de tuméfactions cervicales isolées colligées au service d'ORL de l'hôpital militaire Avicenne de Marrakech entre 2001 et 2014. Tous nos patients ont bénéficié d'une cervicotomie exploratrice avec étude anatomo-pathologique. L’âge des patients varie entre 1 et 76 ans avec un âge moyen de 32,57 ans et une légère prédominance masculine de 52%. La symptomatologie qui a motivé une consultation chez 81% des patients était la tuméfaction latérocervicale. La localisation la plus fréquente était sous mandibulaire (33,34%). Les tuméfactions d'installation progressive ont été retrouvées chez 93,34% des patients. Les principales étiologies retrouvées dans notre étude après examen anatomopathologique étaient de deux types: soit d'origine ganglionnaire dominées par la tuberculose ganglionnaire cervicale (53,66%), le lymphome malin non hodgkinien (6,66%), les adénites réactionnelles non spécifiques (4,66%), la maladie deHodgkin (4,33%) et les métastases ganglionnaires cervicales (3,33%); soit d'origine non ganglionnaire dont le lipome cervicale (17,66%), les kystes branchiaux (6%), les kystes du tractus thyréoglosse (1,66%) et le lymphangiome kystique (1,66%). A la lumière des résultats obtenus et des données de la littérature, nous allons discuter l'intérêt et l'utilité de la cervicotomie exploratrice dans le diagnostic étiologique des tuméfactions cervicales lorsque les examens cliniques et paracliniques ne sont pas concluants, et ainsi d'analyser les aspects �

A Hybrid Optimization Algorithm for Low RCS Antenna Design

Directory of Open Access Journals (Sweden)

W. Shao

2012-12-01

Full Text Available In this article, a simple and efficient method is presented to design low radar cross section (RCS patch antennas. This method consists of a hybrid optimization algorithm, which combines a genetic algorithm (GA with tabu search algorithm (TSA, and electromagnetic field solver. The TSA, embedded into the GA frame, defines the acceptable neighborhood region of parameters and screens out the poor-scoring individuals. Thus, the repeats of search are avoided and the amount of time-consuming electromagnetic simulations is largely reduced. Moreover, the whole design procedure is auto-controlled by programming the VBScript language. A slot patch antenna example is provided to verify the accuracy and efficiency of the proposed method.

Improvement on RCS reduction using flat lossy focusing reflectors.

Science.gov (United States)

Chin, Cheng-Yuan; Jou, Christina F

2013-12-30

In this paper, we propose a planar non-periodic subwavelength resistive grating (SWRG). The phase front of the scattered fields can be completely manipulated through non-periodic design of the grating while high absorptivity is preserved. The SWRG has an interesting property similar to a resistive concave reflecting lens. Scattered wave is focused in the near-field region, and spread out in the far-field. This feature of non-periodic resistive grating can improve the original radar cross section (RCS) reduction up to 22.86 dB in the boresight direction comparing to the periodic counterpart. Non-periodic design of SWRG could have a substantial impact on stealth technology, aerospace engineering, and microwave anechoic chamber.

Fokus på fremme af livskvalitet og trivsel hos personer med demens gennem læringsmodel med musikterapi og Dementia Care Mapping som det fælles omdrejningspunkt

DEFF Research Database (Denmark)

Ottesen, Aase Marie

. Beskrivelse af den metode som er anvendt Metodisk er projektet tilrettelagt som et casestudie af et musikterapiforløb. I læringsmodellen tages afsæt i Tom Kitwoods teori og værdigrundlag om en personorienteret omsorg. Dementia Care Mapping (DCM) anvendes i læringsforløbet til at belyse de relationelle møder......, der opstår i musikterapien. Samtidig anvendes DCM som pædagogisk metode i feedbackprocessen med omsorgsgiverne, hvor der arbejdes på at give omsorgsgiverne redskaber til at bruge musik aktivt i deres interaktion med personer med demens i forskellige samværssituationer. Projektets teoretiske...

World Register of marine Cave Species (WoRCS: a new Thematic Species Database for marine and anchialine cave biodiversity

Directory of Open Access Journals (Sweden)

Vasilis Gerovasileiou

2016-09-01

Full Text Available Scientific exploration of marine cave environments and anchialine ecosystems over recent decades has led to outstanding discoveries of novel taxa, increasing our knowledge of biodiversity. However, biological research on underwater caves has taken place only in a few areas of the world and relevant information remains fragmented in isolated publications and databases. This fragmentation makes assessing the conservation status of marine cave species especially problematic, and this issue should be addressed urgently given the stresses resulting from planned and rampant development in the coastal zone worldwide. The goal of the World Register of marine Cave Species (WoRCS initiative is to create a comprehensive taxonomic and ecological database of known species from marine caves and anchialine systems worldwide and to present this as a Thematic Species Database (TSD of the World Register of marine Species (WoRMS. WoRCS will incorporate ecological data (e.g., type of environment, salinity regimes, and cave zone as well as geographical information on the distribution of species in cave and anchialine environments. Biodiversity data will be progressively assembled from individual database sources at regional, national or local levels, as well as from literature sources (estimate: >20,000 existing records of cave-dwelling species scattered in several databases. Information will be organized in the WoRCS database following a standard glossary based on existing terminology. Cave-related information will be managed by the WoRCS thematic editors with all data dynamically linked to WoRMS and its team of taxonomic editors. In order to mobilize data into global biogeographic databases, a Gazetteer of the Marine and Anchialine Caves of the World will be established. The presence records of species could be eventually georeferenced for submission to the Ocean Biogeographic Information System (OBIS and constitute an important dataset for biogeographical and

Ledelsesretten - hvad skal vi stille op med den?

DEFF Research Database (Denmark)

Pagh, Lone

2016-01-01

for ledelsesretten at træde ind som en kommunikerbar og legitim rammesætning i lederens praksis. Artiklen inddrager i sin analyse retssociologiske perspektiver i et moderne og postmoderne perspektiv og rundes af med en diskussion af de faldgruber, det kan indebære, når ledelsesrettens styringssprog skal omsættes til...

25 år med selvbestemt abort i Norge

OpenAIRE

Vigran, Åsne; Lappegård, Trude

2003-01-01

Artiklene i Samfunnsspeilet er tilgjengelige fra SSBs nettsider: http://www.ssb.no/ssp/ Lov om selvbestemt abort ble vedtatt 30. mai 1978 og trådte i kraft året etter. Motstanderne av loven fryktet økte aborttall. 25 år etter at loven ble vedtatt, er aborttallene nedadgående. Dette gjelder spesielt blant tenåringsjenter, hvor dagens abortrate er 30 prosent lavere enn for 25 år siden.

Læringslandskaber for elever med indlæringsvanskeligheder

DEFF Research Database (Denmark)

Szulevicz, Thomas

Baggrund Denne afhandling består af en empirisk undersøgelse af den pædagogiske praksis på Havredal Praktiske Landbrugsskole (HPL). HPL er en mesterlæreinspireret landbrugsuddannelse for unge elever mellem 16-25 år med indlæringsvanskeligheder. HPL fungerer som et moderne landbrug, der drives af...... elever og lærere i fællesskab. Der er 38 indskrevne elever på skolen, der dyrker 140 ha jord og har en besætning på 50 sortbrogede malkekøer i løsdriftsstald, 250 søer samt 10 heste. Elevernes uddannelse og læring er struktureret omkring deres deltagelse i landbrugsaktiviteterne på skolen. HPL er...... observationerne fandt sted i forskningsprojektets første 14 måneder. Herudover er der blevet foretaget kvalitative interviews med 12 elever fra HPL. Heraf blev de 7 af eleverne interviewet à 3 omgange. 7 lærere på HPL er blevet interviewet. Endelig er der blevet foretaget to videoobservationer af en elevs...

Usikkerhed som følgesvend når børn dør på intensiv afdeling

DEFF Research Database (Denmark)

Sørensen, Anne Boier; Aagaard, Hanne

2015-01-01

-ældre og familie, når beslutning om behandlingsophør er truffet og barnet dør. Dette studie inklude-rer ti empiriske artikler fra perioden 1997-2010. Artiklerne blev udvalgt på baggrund af en systema-tisk søgning i databaserne: PubMed, CINAHL, Scopus, PsycINFO og SweMed+. Max van Manens 4 eksistentialer...

Usikkerhed som følgesvend når børn dør på intensiv afdeling

DEFF Research Database (Denmark)

Sørensen, Anne Boier; Aagaard, Hanne

2015-01-01

, forældre og familie, når beslutning om behandlingsophør er truffet og barnet dør. Dette studie inkluderer ti empiriske artikler fra perioden 1997–2010. Artiklerne blev udvalgt på baggrund af en systematisk søgning i databaserne: PubMed, CINAHL, Scopus, PsycINFO og SweMed+. Max van Manens fire...

PRDM16 enhances nuclear receptor-dependent transcription of the brown fat-specific Ucp1 gene through interactions with Mediator subunit MED1.

Science.gov (United States)

Iida, Satoshi; Chen, Wei; Nakadai, Tomoyoshi; Ohkuma, Yoshiaki; Roeder, Robert G

2015-02-01

PR domain-containing 16 (PRDM16) induces expression of brown fat-specific genes in brown and beige adipocytes, although the underlying transcription-related mechanisms remain largely unknown. Here, in vitro studies show that PRDM16, through its zinc finger domains, directly interacts with the MED1 subunit of the Mediator complex, is recruited to the enhancer of the brown fat-specific uncoupling protein 1 (Ucp1) gene through this interaction, and enhances thyroid hormone receptor (TR)-driven transcription in a biochemically defined system in a Mediator-dependent manner, thus providing a direct link to the general transcription machinery. Complementary cell-based studies show that upon forskolin treatment, PRDM16 induces Ucp1 expression in undifferentiated murine embryonic fibroblasts, that this induction depends on MED1 and TR, and, consistent with a direct effect, that PRDM16 is recruited to the Ucp1 enhancer. Related studies have defined MED1 and PRDM16 interaction domains important for Ucp1 versus Ppargc1a induction by PRDM16. These results reveal novel mechanisms for PRDM16 function through the Mediator complex. © 2015 Iida et al.; Published by Cold Spring Harbor Laboratory Press.

Den fuldt åbne MOOC med afsæt i aktuelle deltagere

DEFF Research Database (Denmark)

Hansbøl, Mikala; Erkmann, Malene; Munksgaard, Marianne Eilsø

2015-01-01

I dette afsnit præsenterer vi nogle af erfaringerne fra arbejdet med fire versioner af Videnskabsteori MOOC’en. Erfaringerne tager afsæt i vores kvalitative undersøgelser af deltagerperspektiver (UCSJ undervisere og MOOC deltagere) på MOOC-understøttet undervisning i, og læring af, anvendt...... videnskabsteori. MOOC litteraturen havde indtil 2013 primært beskæftiget sig med universitetsuddannelse, og der var stort set ikke skrevet noget om MOOCs i en dansk sammenhæng. Kjærgaard et al. (2013) leverede et første dansk bidrag, der kobler MOOCs med professionshøjskolerne i Danmark. Arbejdet med...... Videnskabsteori MOOC’en har især taget afsæt i en interesse i at forstå samspillet mellem deltagerforudsætninger, interesser og behov, og læringsmulighederne med MOOC’en. På den baggrund udpeger vi nogle væsentlige designelementer, der kan medtænkes i fremtidige udviklinger af tilsvarende fuldt åbne MOOCs...

Cerebral lesions and event-related potential P300 using positron emission tomography (PET)

International Nuclear Information System (INIS)

Sakai, Yasujiro; Okamoto, Kazuma; Tanaka, Makoto; Kondoh, Susumu; Hirai, Shunsaku

1993-01-01

To determine what lesions are involved in prolonging event-related potential P300 latency, regional cerebral blood flow (rCBF) and metabolism were investigated by positron emission tomography (PET) in a total of 40 patients with neurologic diseases (12 with chronic cerebrovascular disorder, 9 with spino-cerebellar degeneration, 4 with Alzheimer's type dementia, 4 with amyotrophic lateral sclerosis, and 11 with miscellaneous diseases). There was inverse correlation between rCBF and P300 latency in terms of any of the whole, left, and right hemispheres: P300 latency was associated with decreased rCBF. This was more noticeable in the cerebral cortex than white matter and in the right than left hemisphere, although there was no significant difference between them. In none of the regions, however, was there significant correlation between cerebral oxygen consumption and P300 latency. When the right and left frontal, temporal, parietal and occipital cortexes, thalamus, putamen, and caudatum were examined as regions of interest, there was significantly inverse correlation between rCBF and P300 latency in all regions except for the occipital cortex. This was more noticeable on the right than the left side, although no significant difference was observed. Cerebral oxygen consumption in these lesions did not correlate with P300 latency. In the study on bilateral rCBF difference, decreased rCBF confined to the right parietal lobe, bilateral thalamus and bilateral temporal lobes was found to be associated with a significantly prolonged P300 latency. Thus, rCBF in these regions seemed to be particularly responsible for P300 latency. (N.K.)

Cerebral lesions and event-related potential P300 using positron emission tomography (PET)

Energy Technology Data Exchange (ETDEWEB)

Sakai, Yasujiro; Okamoto, Kazuma; Tanaka, Makoto; Kondoh, Susumu; Hirai, Shunsaku (Gunma Univ., Maebashi (Japan). School of Medicine)

1993-06-01

To determine what lesions are involved in prolonging event-related potential P300 latency, regional cerebral blood flow (rCBF) and metabolism were investigated by positron emission tomography (PET) in a total of 40 patients with neurologic diseases (12 with chronic cerebrovascular disorder, 9 with spino-cerebellar degeneration, 4 with Alzheimer's type dementia, 4 with amyotrophic lateral sclerosis, and 11 with miscellaneous diseases). There was inverse correlation between rCBF and P300 latency in terms of any of the whole, left, and right hemispheres: P300 latency was associated with decreased rCBF. This was more noticeable in the cerebral cortex than white matter and in the right than left hemisphere, although there was no significant difference between them. In none of the regions, however, was there significant correlation between cerebral oxygen consumption and P300 latency. When the right and left frontal, temporal, parietal and occipital cortexes, thalamus, putamen, and caudatum were examined as regions of interest, there was significantly inverse correlation between rCBF and P300 latency in all regions except for the occipital cortex. This was more noticeable on the right than the left side, although no significant difference was observed. Cerebral oxygen consumption in these lesions did not correlate with P300 latency. In the study on bilateral rCBF difference, decreased rCBF confined to the right parietal lobe, bilateral thalamus and bilateral temporal lobes was found to be associated with a significantly prolonged P300 latency. Thus, rCBF in these regions seemed to be particularly responsible for P300 latency. (N.K.).

On the COSMO-SkyMed Exploitation for Interferometric DEM Generation

Science.gov (United States)

Teresa, C. M.; Raffaele, N.; Oscar, N. D.; Fabio, B.

2011-12-01

Work supported by ASI (Agenzia Spaziale Italiana) in the framework of the project "AO-COSMO Project ID-1462 - Feasibility of possible use of COSMO/SkyMed in bistatic SAR Earth observation - ASI Contract I/063/09/0". References [1] B. Rabus, M. Eineder, A. Roth, and R. Bamler, "The Shuttle Radar Topography Mission-A new class of digital elevation models acquired by spaceborne radar," ISPRS J. Photogramm. Remote Sens., vol. 57, no. 4, pp. 241-262, Feb. 2003. [2] F. BOVENGA, D. O. NITTI, R. NUTRICATO, M. T. CHIARADIA, "C- and X-band multi-pass InSAR analysis over Alpine and Apennine regions". In Proceedings of the European Space Agency Living Planet Symposium, June 28 - July 2, 2010, Bergen, Norway. [3] D. REALE, D. O. NITTI, D. PEDUTO, R. NUTRICATO, F. BOVENGA, G. FORNARO, "Postseismic Deformation Monitoring With The COSMO/SKYMED Constellation". IEEE Geoscience Remote Sensing Letters, 2011. DOI: 10.1109/LGRS.2010.2100364 [4] Nitti, D.O., Nutricato, R., Bovenga, F., Conte, D., Guerriero, L. & Milillo, G., "Quantitative Analysis of Stripmap And Spotlight SAR Interferometry with CosmoSkyMed constellation.", Proceedings if IEEE IGARSS 2009, July 13-17, 2009. Cape Town, South Africa.

Mediator Recruitment to Heat Shock Genes Requires Dual Hsf1 Activation Domains and Mediator Tail Subunits Med15 and Med16*

Science.gov (United States)

Kim, Sunyoung; Gross, David S.

2013-01-01

The evolutionarily conserved Mediator complex is central to the regulation of gene transcription in eukaryotes because it serves as a physical and functional interface between upstream regulators and the Pol II transcriptional machinery. Nonetheless, its role appears to be context-dependent, and the detailed mechanism by which it governs the expression of most genes remains unknown. Here we investigate Mediator involvement in HSP (heat shock protein) gene regulation in the yeast Saccharomyces cerevisiae. We find that in response to thermal upshift, subunits representative of each of the four Mediator modules (Head, Middle, Tail, and Kinase) are rapidly, robustly, and selectively recruited to the promoter regions of HSP genes. Their residence is transient, returning to near-background levels within 90 min. Hsf1 (heat shock factor 1) plays a central role in recruiting Mediator, as indicated by the fact that truncation of either its N- or C-terminal activation domain significantly reduces Mediator occupancy, whereas removal of both activation domains abolishes it. Likewise, ablation of either of two Mediator Tail subunits, Med15 or Med16, reduces Mediator recruitment to HSP promoters, whereas deletion of both abolishes it. Accompanying the loss of Mediator, recruitment of RNA polymerase II is substantially diminished. Interestingly, Mediator antagonizes Hsf1 occupancy of non-induced promoters yet facilitates enhanced Hsf1 association with activated ones. Collectively, our observations indicate that Hsf1, via its dual activation domains, recruits holo-Mediator to HSP promoters in response to acute heat stress through cooperative physical and/or functional interactions with the Tail module. PMID:23447536

Transport properties of Y1-xRxCo2 (R=Er, Ho) in magnetic field

International Nuclear Information System (INIS)

Uchima, Kiyoharu; Nakama, Takao; Takaesu, Yoshinao; Misashi, Masataka; Yagasaki, Katsuma; Hedo, Masato; Uwatoko, Yoshiya; Burkov, Alexander T.

2006-01-01

Thermopower S and resistivity ρ of Y 1-x R x Co 2 (R=Er, Ho) compounds have been measured in the temperature range from 1.5 to 300-bar K under magnetic fields up to 15-bar T. Strong enhancement of resistivity and fundamental changes in temperature variation of thermopower are observed at low temperatures in the compounds within the composition range where uniform Co 3d magnetization collapses. The magnetic state of Co 3d electrons has a dominant effect on the characteristic behavior of S and ρ in these compounds

Interview med børn

DEFF Research Database (Denmark)

Interview med børn handler om børneinterview i forbindelse med forskning. Bogen er tænkt som inspiration til og afsæt for metodiske refleksioner i forbindelse med inddragelse af børn som informanter.......Interview med børn handler om børneinterview i forbindelse med forskning. Bogen er tænkt som inspiration til og afsæt for metodiske refleksioner i forbindelse med inddragelse af børn som informanter....

Rapport for Center for Vildtsundhed 1. halvår 2012

DEFF Research Database (Denmark)

Chriél, Mariann; Enemark, Heidi L.; Therkildsen, Ole Roland

for vurderingen af parasitbelastningen hos raske ederfugle. Redemateriale til undersøgelse af Pasteurella multocida, der forårsager udbrud af fjerkrækolera, fortsættes i et specialestudie af de dyrkbare bakterier. Med henblik på kortlægning af rævens dværgbændelorm (Echinococcus multilocularis) hos mårhund og ræv...... Danmark siden 2000, og det er første gang bændelormen er påvist i jyske ræve. Echinococcus multilocularis kan smitte til mennesker, hvor de i larvestadiet angriber leveren, hvilket kan have fatale følger, så det er vigtigt, at folk er opmærksomme på risikoen og tager deres forbehold. Mennesker smittes...

Virtuelt skrivebord med open office

DEFF Research Database (Denmark)

Nielsen, Kurt Gammelgaard

2009-01-01

SDUs erfaringer med projektet Port 22: en virtuel platform med Open Office som kontorpakke til studerende.......SDUs erfaringer med projektet Port 22: en virtuel platform med Open Office som kontorpakke til studerende....

Ledarskapet och de två faktorerna : En induktiv studie för att förstå hur organisationsfaktorer och könsstereotyper påverkar ledarskap

OpenAIRE

Larsson, Hampus; Tang, Vinh; Vannfält, Jessica

2018-01-01

Sammanfattning   Titel: Ledarskapet och de två faktorerna: En induktiv studie för att förstå hur organisationsfaktorer och könsstereotyper påverkar ledarskap.   Seminariedatum: 2018-01-09   Akademi: Akademin för Ekonomi, Samhälle och Teknik, Mälardalen Högskola   Ämne/kurs: FOA300, examensarbete i företagsekonomi på kandidatnivå.   Författare: Larsson, Hampus 930903, Tang, Vinh 940523, Vannfält, Jessica 911031   Handledare: Magnus Linderström   Syfte: Syftet med denna studie är att genom en i...

Serratia marcescens ShlA pore-forming toxin is responsible for early induction of autophagy in host cells and is transcriptionally regulated by RcsB.

Science.gov (United States)

Di Venanzio, Gisela; Stepanenko, Tatiana M; García Véscovi, Eleonora

2014-09-01

Serratia marcescens is a Gram-negative bacterium that thrives in a wide variety of ambient niches and interacts with an ample range of hosts. As an opportunistic human pathogen, it has increased its clinical incidence in recent years, being responsible for life-threatening nosocomial infections. S. marcescens produces numerous exoproteins with toxic effects, including the ShlA pore-forming toxin, which has been catalogued as its most potent cytotoxin. However, the regulatory mechanisms that govern ShlA expression, as well as its action toward the host, have remained unclear. We have shown that S. marcescens elicits an autophagic response in host nonphagocytic cells. In this work, we determine that the expression of ShlA is responsible for the autophagic response that is promoted prior to bacterial internalization in epithelial cells. We show that a strain unable to express ShlA is no longer able to induce this autophagic mechanism, while heterologous expression of ShlA/ShlB suffices to confer on noninvasive Escherichia coli the capacity to trigger autophagy. We also demonstrate that shlBA harbors a binding motif for the RcsB regulator in its promoter region. RcsB-dependent control of shlBA constitutes a feed-forward regulatory mechanism that allows interplay with flagellar-biogenesis regulation. At the top of the circuit, activated RcsB downregulates expression of flagella by binding to the flhDC promoter region, preventing FliA-activated transcription of shlBA. Simultaneously, RcsB interaction within the shlBA promoter represses ShlA expression. This circuit offers multiple access points to fine-tune ShlA production. These findings also strengthen the case for an RcsB role in orchestrating the expression of Serratia virulence factors. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Reduction of the In-Band RCS of Microstrip Patch Antenna by Using Offset Feeding Technique

Directory of Open Access Journals (Sweden)

Weiwei Xu

2014-01-01

Full Text Available This paper presents a method for implementing a low in-band scattering design for microstrip patch antennas based on the analysis of structural mode scattering and radiation characteristics. The antenna structure is first designed to have the lowest structural mode scattering in a desired frequency band. The operating frequency band of the antenna is then changed to coincide with that of the lowest structural mode scattering by adjusting the feed position on the antenna (offset feeding to achieve an antenna with low in-band radar cross section (RCS. In order to reduce the level of cross polarization of the antenna caused by offset feeding, symmetry feeding structures for both single patch antennas and two-patch arrays are proposed. Examples that show the efficiency of the method are given, and the results illustrate that the in-band RCS of the proposed antennas can be reduced by as much as 17 dBsm for plane waves impinging from the normal direction compared to patch antennas fed by conventional methods.

Mediator Complex Subunits MED2, MED5, MED16, and MED23 Genetically Interact in the Regulation of Phenylpropanoid Biosynthesis.

Science.gov (United States)

Dolan, Whitney L; Dilkes, Brian P; Stout, Jake M; Bonawitz, Nicholas D; Chapple, Clint

2017-12-01

The phenylpropanoid pathway is a major global carbon sink and is important for plant fitness and the engineering of bioenergy feedstocks. In Arabidopsis thaliana , disruption of two subunits of the transcriptional regulatory Mediator complex, MED5a and MED5b, results in an increase in phenylpropanoid accumulation. By contrast, the semidominant MED5b mutation reduced epidermal fluorescence4-3 ( ref4-3 ) results in dwarfism and constitutively repressed phenylpropanoid accumulation. Here, we report the results of a forward genetic screen for suppressors of ref4-3. We identified 13 independent lines that restore growth and/or phenylpropanoid accumulation in the ref4-3 background. Two of the suppressors restore growth without restoring soluble phenylpropanoid accumulation, indicating that the growth and metabolic phenotypes of the ref4-3 mutant can be genetically disentangled. Whole-genome sequencing revealed that all but one of the suppressors carry mutations in MED5b or other Mediator subunits. RNA-seq analysis showed that the ref4-3 mutation causes widespread changes in gene expression, including the upregulation of negative regulators of the phenylpropanoid pathway, and that the suppressors reverse many of these changes. Together, our data highlight the interdependence of individual Mediator subunits and provide greater insight into the transcriptional regulation of phenylpropanoid biosynthesis by the Mediator complex. © 2017 American Society of Plant Biologists. All rights reserved.

National demonstration of full reactor coolant system (RCS) chemical decontamination at Indian Point 2

Energy Technology Data Exchange (ETDEWEB)

Trovato, S.A.; Parry, J.O. [Consolidated Edison Co., New York, NY (United States)

1995-03-01

Key to the safe and efficient operation of the nation`s civilian nuclear power plants is the performance of maintenance activities within regulations and guidelines for personnel radiation exposure. However, maintenance activities, often performed in areas of relatively high radiation fields, will increase as the nation`s plant age. With the Nuclear Regulatory Commission (NRC) lowering the allowable radiation exposure to plant workers in 1994 and considering further reductions and regulations in the future, it is imperative that new techniques be developed and applied to reduce personnel exposure. Full primary system chemical decontamination technology offers the potential to be single most effective method of maintaining workers exposure {open_quotes}as low as reasonably achievable{close_quotes} (ALARA) while greatly reducing plant operation and maintenance (O&M) costs. A three-phase program underway since 1987, has as its goal to demonstrate that full RCS decontamination is a visible technology to reduce general plant radiation levels without threatening the long term reliability and operability of a plant. This paper discusses research leading to and plans for a National Demonstration of Full RCS Chemical Decontamination at Indian Point 2 nuclear generating station in 1995.

Reproducibility in Natural Language Processing: A Case Study of Two R Libraries for Mining PubMed/MEDLINE

Science.gov (United States)

Cohen, K. Bretonnel; Xia, Jingbo; Roeder, Christophe; Hunter, Lawrence E.

2018-01-01

There is currently a crisis in science related to highly publicized failures to reproduce large numbers of published studies. The current work proposes, by way of case studies, a methodology for moving the study of reproducibility in computational work to a full stage beyond that of earlier work. Specifically, it presents a case study in attempting to reproduce the reports of two R libraries for doing text mining of the PubMed/MEDLINE repository of scientific publications. The main findings are that a rational paradigm for reproduction of natural language processing papers can be established; the advertised functionality was difficult, but not impossible, to reproduce; and reproducibility studies can produce additional insights into the functioning of the published system. Additionally, the work on reproducibility lead to the production of novel user-centered documentation that has been accessed 260 times since its publication—an average of once a day per library. PMID:29568821

Distribution of Synthetic Cannabinoids JWH-210, RCS-4 and Δ 9-Tetrahydrocannabinol After Intravenous Administration to Pigs.

Science.gov (United States)

Schaefer, Nadine; Kettner, Mattias; Laschke, Matthias W; Schlote, Julia; Ewald, Andreas H; Menger, Michael D; Maurer, Hans H; Schmidt, Peter H

2017-01-01

Synthetic cannabinoids (SCs) have become an increasing issue in forensic toxicology. Controlled human studies evaluating pharmacokinetic data of SCs are lacking and only few animal studies have been published. Thus, an interpretation of analytical results found in intoxicated or poisoned individuals is difficult. Therefore, the distribution of two selected SCs, namely 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-210) and 2-(4-methoxyphenyl)-1-(1- pentyl-indol-3-yl)methanone (RCS-4) as well as Δ9-tetrahydrocannabinol (THC) as reference were examined in pigs. Pigs (n = 6 per drug) received a single intravenous 200 μg/kg BW dose of JWH-210, RCS- 4, or THC. Six hours after administration, the animals were exsanguinated and relevant organs, important body fluids such as bile, and tissues such as muscle and adipose tissue, as well as the bradytrophic specimens dura and vitreous humor were collected. After hydrolysis and solid phase extraction, analysis was performed by LC-MS/MS. To overcome matrix effects of the LC-MS/MS analysis, a standard addition method was applied for quantification. The parent compounds could be detected in every analyzed specimen with the exception of THC that was not present in dura and vitreous humor. Moderate concentrations were present in brain, the site of biological effect. Metabolite concentrations were highest in tissues involved in metabolism and/or elimination Conclusions: Besides kidneys and lungs routinely analyzed in postmortem toxicology, brain, adipose, and muscle tissue could serve as alternative sources, particularly if other specimens are not available. Bile fluid is the most appropriate specimen for SCs and THC metabolites detection. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Distribution of Synthetic Cannabinoids JWH-210, RCS-4 and ∆ 9-Tetrahydrocannabinol After Intravenous Administration to Pigs

Science.gov (United States)

Schaefer, Nadine; Kettner, Mattias; Laschke, Matthias W.; Schlote, Julia; Ewald, Andreas H.; Menger, Michael D.; Maurer, Hans H.; Schmidt, Peter H.

2017-01-01

Background: Synthetic cannabinoids (SCs) have become an increasing issue in forensic toxicology. Controlled human studies evaluating pharmacokinetic data of SCs are lacking and only few animal studies have been published. Thus, an interpretation of analytical results found in intoxicated or poisoned individuals is difficult. Therefore, the distribution of two selected SCs, namely 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-210) and 2-(4-methoxyphenyl)-1-(1-pentyl-indol-3-yl)methanone (RCS-4) as well as ∆9-tetrahydrocannabinol (THC) as reference were examined in pigs. Methods: Pigs (n = 6 per drug) received a single intravenous 200 µg/kg BW dose of JWH-210, RCS-4, or THC. Six hours after administration, the animals were exsanguinated and relevant organs, important body fluids such as bile, and tissues such as muscle and adipose tissue, as well as the bradytrophic specimens dura and vitreous humor were collected. After hydrolysis and solid phase extraction, analysis was performed by LC-MS/MS. To overcome matrix effects of the LC-MS/MS analysis, a standard addition method was applied for quantification. Results: The parent compounds could be detected in every analyzed specimen with the exception of THC that was not present in dura and vitreous humor. Moderate concentrations were present in brain, the site of biological effect. Metabolite concentrations were highest in tissues involved in metabolism and/or elimination. Conclusions: Besides kidneys and lungs routinely analyzed in postmortem toxicology, brain, adipose, and muscle tissue could serve as alternative sources, particularly if other specimens are not available. Bile fluid is the most appropriate specimen for SCs and THC metabolites detection. PMID:27834143

Design og analyse af eksperimenter i R

DEFF Research Database (Denmark)

Dahl, Malte Rokkjær

2017-01-01

eksperimentelle studier med afsæt i statistikprogrammet R. Det er håbet, at notatet vil være en hjælp til at reflektere over, designe, og analysere eksperimenter i forbindelse med bachelorprojekter eller specialer - og forhåbentligt også i arbejde med eksperimenter uden for instituttets mure. Notatet berører......, herunder balancetest, hypotesetest med og uden kovariatjustering, interaktioner samt udledning af konfidensintervaller. Det antages, at læseren har et grundlæggende kendskab til R samt til *potentiel outcomes*-frameworket. De indledende kapitler i Gerber & Green (2012) eller Imbens & Athey (2017) er gode...

The study of gravity makeup to RCS for the loss of RHR event during mid-loop operation

International Nuclear Information System (INIS)

Oh, H. S.; Yoon, D. J.; Ha, S. J.; Lee, C. S.

2004-01-01

In case of the loss of residual heat removal system (RHR) event during mid-loop operation, one of the mitigation actions to prevent core uncovery is gravity makeup to the RCS. This study includes the mitigation actions for gravity makeup to the RCS for 3-loop nuclear power plant, minimum gravity makeup flow for prevention of core boiling and core uncovery and possible pass of gravity make up. Also, the evaluation of minimum gravity makeup to prevent core boiling and core uncovery was performed using the RELAP/MOD3.2.2beta code. The results of this study show that the minimum flow to prevent core uncovery in case of cold leg injection (about 20m 3 /hr) is too small to recover the core water level. So, our conclusion is that the minimum flow to prevent core boiling (about 170m 3 /hr) is enough to recover core water level

CRE promoter sites modulate alternative splicing via p300-mediated histone acetylation

Czech Academy of Sciences Publication Activity Database

Dušková, E.; Hnilicová, Jarmila; Staněk, D.

2014-01-01

Roč. 11, č. 7 (2014), s. 1-10 ISSN 1547-6286 R&D Projects: GA ČR(CZ) GBP305/12/G034 Grant - others:Charles University Prague(CZ) 274111 Institutional support: RVO:61388971 Keywords : alternative splicing * fibronectin * p300 Subject RIV: EE - Microbiology, Virology Impact factor: 4.974, year: 2014

Remedial action and waste disposal project -- 300-FF-1 remedial action readiness assessment report

International Nuclear Information System (INIS)

Carson, J.W.; Carlson, R.A.; Greif, A.A.; Johnson, C.R.; Orewiler, R.I.; Perry, D.M.; Remsen, W.E.; Tuttle, B.G.; Wilson, R.C.

1997-09-01

This report documents the readiness assessment for initial startup of the 300-FF-1 Remedial Action Task. A readiness assessment verifies and documents that field activities are ready to start (or restart) safely. The 300-FF-1 assessment was initiated in April 1997. Readiness assessment activities included confirming the completion of project-specific procedures and permits, training staff, obtaining support equipment, receipt and approval of subcontractor submittals, and mobilization and construction of site support systems. The scope of the 300-FF-1 Remedial Action Task includes excavation and disposal of contaminated soils at liquid waste disposal facilities and of waste in the 618-4 Burial Ground and the 300-FF-1 landfills. The scope also includes excavation of test pits and test trenches

Phase I remedial investigation report for the 300-FF-5 operable unit, Volume 1

Energy Technology Data Exchange (ETDEWEB)

NONE

1994-01-01

The focus of this remedial investigation (RI) is the 300-FF-5 operable unit, one of five operable units associated with the 300 Area aggregate of the U.S. Department of Energy`s (DOE`s) Hanford Site. The 300-FF-5 operable unit is a groundwater operable unit beneath the 300-FF-1, 300-FF-2, and 300-FF-3 source operable units. This operable unit was designated to include all contamination detected in the groundwater and sediments below the water table that emanates from the 300-FF-1, 300-FF-2, and 300-FF-3 operable units (DOE-RL 1990a). In November 1989, the U.S. Environmental Protection Agency (EPA) placed the 300 Area on the National Priorities List (NPL) contained within Appendix B of the National Oil and Hazardous Substance Pollution Contingency Plan (NCP, 53 FR 51391 et seq.). The EPA took this action pursuant to their authority under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA, 42 USC 9601 et seq.). The DOE Richland Operations Office (DOE-RL), the EPA and Washington Department of Ecology (Ecology) issued the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement), in May 1989 (Ecology et al. 1992, Rev. 2). This agreement, among other matters, governs all CERCLA efforts at the Hanford Site. In June 1990, a remedial investigation/feasibility study (RI/FS) workplan for the 300-FF-5 operable unit was issued pursuant to the Tri-Party Agreement.

Phase I remedial investigation report for the 300-FF-5 operable unit, Volume 1

International Nuclear Information System (INIS)

1994-01-01

The focus of this remedial investigation (RI) is the 300-FF-5 operable unit, one of five operable units associated with the 300 Area aggregate of the U.S. Department of Energy's (DOE's) Hanford Site. The 300-FF-5 operable unit is a groundwater operable unit beneath the 300-FF-1, 300-FF-2, and 300-FF-3 source operable units. This operable unit was designated to include all contamination detected in the groundwater and sediments below the water table that emanates from the 300-FF-1, 300-FF-2, and 300-FF-3 operable units (DOE-RL 1990a). In November 1989, the U.S. Environmental Protection Agency (EPA) placed the 300 Area on the National Priorities List (NPL) contained within Appendix B of the National Oil and Hazardous Substance Pollution Contingency Plan (NCP, 53 FR 51391 et seq.). The EPA took this action pursuant to their authority under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA, 42 USC 9601 et seq.). The DOE Richland Operations Office (DOE-RL), the EPA and Washington Department of Ecology (Ecology) issued the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement), in May 1989 (Ecology et al. 1992, Rev. 2). This agreement, among other matters, governs all CERCLA efforts at the Hanford Site. In June 1990, a remedial investigation/feasibility study (RI/FS) workplan for the 300-FF-5 operable unit was issued pursuant to the Tri-Party Agreement

MedSun Reports

Data.gov (United States)

U.S. Department of Health & Human Services — The Medical Product Safety Network (MedSun) is an adverse event reporting program launched in 2002. The primary goal for MedSun is to work collaboratively with the...

mir-300 promotes self-renewal and inhibits the differentiation of glioma stem-like cells

KAUST Repository

Zhang, Daming

2014-01-28

MicroRNAs (miRNAs) are small noncoding RNAs that have been critically implicated in several human cancers. miRNAs are thought to participate in various biological processes, including proliferation, cell cycle, apoptosis, and even the regulation of the stemness properties of cancer stem cells. In this study, we explore the potential role of miR-300 in glioma stem-like cells (GSLCs). We isolated GSLCs from glioma biopsy specimens and identified the stemness properties of the cells through neurosphere formation assays, multilineage differentiation ability analysis, and immunofluorescence analysis of glioma stem cell markers. We found that miR-300 is commonly upregulated in glioma tissues, and the expression of miR-300 was higher in GSLCs. The results of functional experiments demonstrated that miR-300 can enhance the self-renewal of GSLCs and reduce differentiation toward both astrocyte and neural fates. In addition, LZTS2 is a direct target of miR-300. In conclusion, our results demonstrate the critical role of miR-300 in GSLCs and its functions in LZTS2 inhibition and describe a new approach for the molecular regulation of tumor stem cells. © 2014 Springer Science+Business Media.

Spilleregler i musikterapi med voksne - oversigter fra faglitteraturen

Directory of Open Access Journals (Sweden)

Ulla Holck

2005-02-01

Full Text Available Artiklen gennemgår udvalgt faglitteratur, der på et overordnet plan beskriver typer af spilleregler i musikterapi med (fortrinsvis voksne klientgrupper. Udgangspunktet er Priestleys anvendelse af begrebet, og hendes inddeling af spilleregler i forhold til forskellige teknikker gennemgås, efterfulgt af en præsentation af opdelinger lavet af henholdsvis Pedersen & Scheiby, Bruscia og Wigram. En af forskellene på opfattelsen af spillereglernes karakter og anvendelse handler om, hvorvidt spillereglerne udelukkende bør have et referentielt indhold med udgangspunkt i klientens psykiske materiale, eller om også rent musikalske (eller nonreferentiellespilleregler kan siges at have en terapeutisk effekt. Artiklens forfatter ser i stedet spørgsmålet i lyset af mange klienters behov for en gradvis introduktion til klinisk improvisation og inddrager i den sammenhæng litteratur om introduktion og assessment af bl.a. Wigram, Hannibal og Jensen. Artiklen er den første i en serie, hvis overordnede mål er at indsamle viden og erfaring om anvendelse af spilleregler i forhold til forskellige klientgrupper. Anden del omhandler udvikling af spilleregler i forhold til børneklientgrupper og findes i næste kapitel i dette årsskrift.

Brand management og den refleksive forbruger - med semiotik som hjælpedisciplin

DEFF Research Database (Denmark)

Hermansen, Judy

2009-01-01

  Kritisk eftertanke er et væsentligt træk ved den refleksive forbruger - ofte parret med en vis negativitet overfor et brand, en reklame eller forbrugerisme i al almindelighed. Den refleksive forbrugertype kommer til udtryk hos for eksempel en anti-branding guru som Naomi Klein og hendes...... bestseller bog "No Logo" eller i græsrodsbevægelsen Adbusters ( https://www.adbusters.org/ ), der efterhånden i mange år har udsendt et månedsmagasin med kritik af forbrugersamfundet og al dets reklame og branding. Disse anti-forbrugs og anti-branding bevægelser udspringer af, og er identifikationspunkter...... - den refleksive forbruger skal have noget, der kan "brande" ham som anderledes end alle mainstreamforbrugerne. Den refleksive forbruger er med andre ord en Feinschmecker og i lighed med - eller måske rettere i endnu højere grad end - alle andre forbrugere signalerer den refleksive forbruger sin...

The MedDRA paradox.

Science.gov (United States)

Merrill, Gary H

2008-11-06

MedDRA (the Medical Dictionary for Regulatory Activities Terminology) is a controlled vocabulary widely used as a medical coding scheme. However, MedDRA's characterization of its structural hierarchy exhibits some confusing and paradoxical features. The goal of this paper is to examine these features, determine whether there is a coherent view of the MedDRA hierarchy that emerges, and explore what lessons are to be learned from this for using MedDRA and similar terminologies in a broad medical informatics context that includes relations among multiple disparate terminologies, thesauri, and ontologies.

Kommunikation ved brug af mobile enheder med digital video i idræt

DEFF Research Database (Denmark)

Langagergaard Rødbro, Lise; Elbæk, Lars

2012-01-01

I artiklen redegøres kort for et projekt, som førte frem til en videoplatform, der er et bud på et ’lukket YouTube’, hvor video filmet med smartphone direkte kan uploades til, og med funktioner specifikt udviklet til skolens idrætsundervisning. Med afsæt i systemisk kommunikationsteori analyseres...... observations- og interviewda-ta for at belyse den kommunikation, der foregår ved brug af platformen. Senere diskuteres resultaterne ud fra kommunikationstrekanten, og der skitseres en model for videostøttet undervisning i idræt ud fra Batesons kommunikations- og læringsniveauer. Gennem analyser af platformens...

Ahn and Son Afr J Tradit Complement Altern Med. (2014) 11(1):28 ...

African Journals Online (AJOL)

cadewumi

Ahn and Son Afr J Tradit Complement Altern Med. (2014) 11(1):28-29 ... The comparisons of the frequency and choice of functional supplements were analysed using Chi-square test with. SPSS (SPSSs 18.0K for ... Significant difference of choice for functional supplements was observed between male and female (p < 0.01) ...

Impact of coronary collaterals on in-hospital and 5-year mortality after ST-elevation myocardial infarction in the contemporary percutaneous coronary intervention era: a prospective observational study

Science.gov (United States)

Hara, Masahiko; Sakata, Yasuhiko; Nakatani, Daisaku; Suna, Shinichiro; Nishino, Masami; Sato, Hiroshi; Kitamura, Tetsuhisa; Nanto, Shinsuke; Hori, Masatsugu; Komuro, Issei

2016-01-01

Objectives To evaluate the short-term and long-term prognostic impacts of acute phase coronary collaterals to occluded infarct-related arteries (IRA) after ST-elevation myocardial infarction (STEMI) in the percutaneous coronary intervention (PCI) era. Design A prospective observational study. Setting Osaka Acute Coronary Insufficiency Study (OACIS) in Japan. Participants 3340 patients with STEMI from the OACIS database who were admitted to hospitals within 24 hours from the onset and who had a completely occluded IRA. Interventions Patients were divided into 4 groups according to the Rentrop collateral score (RCS) by angiography on admission (RCS-0, no visible collaterals; RCS-1, collaterals without IRA filling; RCS-2, collaterals with partial IRA filling; and RCS-3, collaterals with complete IRA filling). Primary outcome measures In-hospital and 5-year mortality. Results Patients with RCS-0/3 were older than patients with RCS-1/2, and the prevalence of previous myocardial infarction was highest in patients with RCS-3. Median peak creatinine phosphokinase levels decreased as RCS increases (p<0.001), suggesting the acute cardioprotective effects of collaterals. Although RCS-1 and RCS-2 collaterals were associated with better in-hospital mortality (adjusted OR 0.48, p=0.046 and 0.38, p=0.010 for RCS-1 and RCS-2, respectively) and 5-year mortality (adjusted HR 0.53, p=0.004 and 0.46, p<0.001 for RCS-1 and RCS-2, respectively) as compared with R-0, presence of RCS-3 collaterals was not associated with improved in-hospital (adjusted OR 1.35, p=0.331) and 5-year mortality (adjusted HR 0.98, p=0.920), possibly because worse clinical profiles in patients with RCS-3 may mask mortality benefit of coronary collaterals. Conclusions Presence of acute phase coronary collaterals such as RCS-1 and RCS-2 were associated with better in-hospital and 5-year mortality after STEMI in the contemporary PCI era. PMID:27412101

Ødelæg alt muligt med et bogstav

DEFF Research Database (Denmark)

Konzack, Lars

2017-01-01

En gang imellem griber en raptus SoMe-Danmark, og så fyldes alles feed med samme slags indhold. Senest overspringshandlede vi med hashtagget #oedelaeg1filmed1bogstav - og alle mulige afledninger af det....

Analysis of specific factors causing RCS pressure boundary cracking

International Nuclear Information System (INIS)

Song, Taek-Ho; Jeong, Il-Seok

2007-01-01

As nuclear power plants become aged, pressure boundary integrity has become so important issue in domestic and foreign nuclear industry that many related research projects are on-going. KEPRI is going to embark a new research project for managing and preventing these kinds of cracks in nuclear power plants (NPPs). Many nuclear power plants experienced pressure boundary stress corrosion cracking (SCC) and shut downed because of it. In USA, V.C. Summer plant experienced reactor coolant pipe SCC near reactor outlet nozzle and Davis Vesse plant experienced reactor head crack around penetration pipe which is used to control rod drive mechanism. In this paper, RCS pressure boundary cracking cases and corrosion potential have been studied to find out what are the specific factors that have affected crack initiations in the reactor coolant pressure boundaries

Hvornår har 1.000 landbrug 90 pct. af landbrugsjorden?

DEFF Research Database (Denmark)

Hansen, Henning Otte

2017-01-01

relativt lige i forhold til resten af EU. De 1.000 største landbrug driver ca. 22 pct. af landbrugsjorden, og andelen er stigende. Selv om strukturudviklingen ser ud til at fortsætte upåvirket af de økonomiske og markedsmæssige forhold, kan man identificere en række forhold, som er drivkræfter bag...... strukturudviklingen. De senere års liberalisering af landbrugsloven har sandsynligvis været med til fremme strukturudviklingen yderligere, og også fjernelsen af EU‘s mælkekvoter ser ud til at have genskabt den hidtidige udvikling. Om strukturudviklingen er en fordel eller en ulempe kan ikke afgøres entydigt, idet...

Radio evidence for the initial stellar mass function in the R associations CMa R1, Mon R1, Mon R2

International Nuclear Information System (INIS)

Pyatunina, T.B.

1985-01-01

The R associations CMa R1 and Mon R1 have been searched for compact 7.6-cm sources with the RATAN-600 radio telescope. The Mon R1 region shows only about the expected number of background radio galaxies; in CMa R1 seven sources of small angular size with S> or =30 mJy have been found, two of them probably background objects. Comparison with optical data for CMa R1, together with previous RATAN-600 data for Mon R2, yields an initial mass function xi(M)proportionalM/sup -2.7plus-or-minus0.7/ for the rather massive (Mroughly-equal10 M/sub sun/) stars in these associations

Lazarus1, a DUF300 Protein, Contributes to Programmed Cell Death Associated with Arabidopsis acd11 and the Hypersensitive Response

DEFF Research Database (Denmark)

Malinovsky, F.G.; Brodersen, P.; Fiil, B.K.

2010-01-01

) mutant exhibits HR-like accelerated cell death, and cell death execution in acd11 shares genetic requirements for HR execution triggered by one subclass of R proteins. Methodology/Principal Findings: To identify genes required for this PCD pathway, we conducted a genetic screen for suppressors of acd11......Background: Programmed cell death (PCD) is a necessary part of the life of multi-cellular organisms. A type of plant PCD is the defensive hypersensitive response (HR) elicited via recognition of a pathogen by host resistance (R) proteins. The lethal, recessive accelerated cell death 11 (acd11......, here called lazarus (laz) mutants. In addition to known suppressors of R protein-mediated HR, we isolated 13 novel complementation groups of dominant and recessive laz mutants. Here we describe laz1, which encodes a protein with a domain of unknown function (DUF300), and demonstrate that LAZ1...

Al-muammar et al., Afr J Tradit Complement Altern Med. (2016) 13(1 ...

African Journals Online (AJOL)

PROF ADEWUNMI

Al-muammar et al., Afr J Tradit Complement Altern Med. (2016) 13(1):17- .... Feed and water were provided ad libitum for one week before the start of experiment for adaptation. The basal .... The mean value of feed intake (g/day/rat) for all treated groups was slightly reduced as compared to the negative control group. On the.

Differences and similarities between behavior of Fukushima-derived and Chernobyl-derived radiocesium in the environment

Science.gov (United States)

Konoplev, Alexei; Nanba, Kenji; Onda, Yuichi; Golosov, Valentin; Wakiyama, Yoshifumi; Takase, Tsugiko; Yoschenko, Vasyl; Zheleznyak, Mark

2016-04-01

The mobility and bioavailability of radiocesium (r-Cs) of accidental origin is governed by the ratio of its chemical forms in fallout and site-specific environmental characteristics determining the rates of leaching, fixation-remobilization, as well as sorption-desorption of the mobile fraction (its solid-liquid distribution). R-Cs in the environment is strongly bound to soil and sediment particles containing micaceous clay minerals (illite, vermiculite, etc.). This is associated with two basic processes - high selective reversible sorption and fixation. Climate and geographical conditions for Fukushima Prefecture of Japan and Chernobyl zone differ. For example, the catchments of the Chernobyl zone are flat and characterized by low slopes, while Fukushima's watersheds are hilly with steep slopes. Annual precipitation also differs substantially, with annual average for Fukushima about 3 times higher than at Chernobyl. The soils on the north-east coast of the Honshu island that were primarily affected by the radioactive contamination from the Fukushima Daiichi nuclear power plant (FDNPP) accident differ significantly from the Chernobyl zone soils. The proportion of clays such as illite, vermiculite etc. is 20-30% at Fukushima, which is higher than in the sandy loam soils of the Chernobyl zone. In addition to the landscape differences, the speciation of r-Cs in fallout was also different between Fukushima and Chernobyl. It is a challenge to compare r-Cs behavior in FDNPP and Chernobyl zones. Comparative analysis has been carried out for r-Cs wash-off parameters and the distribution coefficient Kd in rivers and surface runoff on Fukushima and Chernobyl contaminated areas for the first years after the accidents. The r-Cs distribution coefficient in Fukushima rivers was 1-2 orders of magnitude higher than correspondent values for rivers and surface runoff of the Chernobyl zone. This suggests higher ability of Fukushima soils and sediments to bind r-Cs. The normalized

Brandingprocessen för konsumtionsprodukten Tazza : En fallstudie

OpenAIRE

Holm, Maria

2012-01-01

Ämnesområdet i studien är branding och temat är brandingprocessen för konsumtions-produkter ur företagets synvinkel. Målet med studien är att beskriva och klargöra för olika element av brandingprocessen via ett case där produkten Tazza står i huvudrollen. Eftersom Tazza är en chokladdryck är den en del av FMCG (Fast Moving Consumer Goods) och CPG segmentet (Consumer Packaged Goods). Inom dessa segment strävar man till att komma på konsumenternas top of mind med starka brand. Brandingproces-se...

Andelsboligforeningslovens § 4 og vilkår i lejeforhold, der stiftes i medfør af bestemmelsen

DEFF Research Database (Denmark)

Graven Nielsen, Kristian; Edlund, Hans Henrik

2013-01-01

Sælges en andelsboligforenings ejendom, har de hidtidige andelshavere efter andelsboligforeningslovens § 4, stk. 1, ret til fortsat brugsret som lejere. I artiklen redegøres for det nærmere indhold af den retsstilling, som bestemmelsen i andelsboligforeningsloven hjemler, herunder især med hensyn...... lejelovgivningens præceptive og deklaratoriske regler, medmindre den ny ejer kan opnå lejerens accept af andre vilkår....

Vilka typer av nyheter har drivit stora prisförändringar hos börsnoterade europeiska fotbollsklubbar? : Är prisförändringarna ekonomiskt rationella?

OpenAIRE

Dagberg, Michael; Yap, Daniel

2016-01-01

Bakgrund: Det som skiljer fotbollsbranschen från övriga företag är att framgång i inte enbart mäts i ökade marknadsandelar eller intäkter utan även utifrån sportsliga framgångar. Traditionell finansteori med utgångspunkt i ekonomisk rationalitet kontrasterar en känslobaserad beteendeekonomi för att förklara vad som driver fotbollsklubbars aktiepriser. Syfte: Syftet med uppsatsen är att identifiera och kartlägga vilka typer av nyheter som har drivit stora prisförändringar och analysera om det ...

miR-625 suppresses cell proliferation and migration by targeting HMGA1 in breast cancer

Energy Technology Data Exchange (ETDEWEB)

Zhou, Wen-bin; Zhong, Cai-neng; Luo, Xun-peng; Zhang, Ya-yuan; Zhang, Gui-ying [Department of Breast Surgery, Second Clinical Medical College of Jinan University, Shenzhen People' s Hospital, Shenzhen, Guangdong Province (China); Zhou, Dong-xian, E-mail: 1072241978@qq.com [Department of Breast Surgery, Second Clinical Medical College of Jinan University, Shenzhen People' s Hospital, Shenzhen, Guangdong Province (China); Liu, Li-ping, E-mail: leoliping@aliyun.com [Department of Hepatobiliary and Pancreas Surgery, Second Clinical Medical College of Jinan University, Shenzhen People' s Hospital, Shenzhen, Guangdong Province (China)

2016-02-19

Dysregulation of microRNA contributes to the high incidence and mortality of breast cancer. Here, we show that miR-625 was frequently down-regulated in breast cancer. Decrease of miR-625 was closely associated with estrogen receptor (P = 0.004), human epidermal growth factor receptor 2 (P = 0.003) and clinical stage (P = 0.001). Kaplan–Meier and multivariate analyses indicated miR-625 as an independent factor for unfavorable prognosis (hazard ratio = 2.654, 95% confident interval: 1.300–5.382, P = 0.007). Re-expression of miR-625 impeded, whereas knockdown of miR-625 enhanced cell viabilities and migration abilities in breast cancer cells. HMGA1 was confirmed as a direct target of miR-625. The expressions of HMGA1 mRNA and protein were induced by miR-625 mimics, but reduced by miR-625 inhibitor. Re-introduction of HMGA1 in cells expressing miR-625 distinctly abrogated miR-625-mediated inhibition of cell growth. Taken together, our data demonstrate that miR-625 suppresses cell proliferation and migration by targeting HMGA1 and suggest miR-625 as a promising prognostic biomarker and a potential therapeutic target for breast cancer. - Highlights: • miR-625 expression was significantly decreased in breast cancer. • Decrease of miR-625 was associated with poor clinical outcomes and unfavorable overall survival. • miR-625 overexpression inhibits cell proliferation and migration in vitro. • miR-625 directly targets and suppresses the expression of HMGA1.

Tandlæger og personer med en spiseforstyrrelse

DEFF Research Database (Denmark)

Gehrt, Charlotte Astrid; Christensen, Lisa Bøge; Klinker, Sabine

2016-01-01

Mødet mellem tandlæge og patient med spiseforstyrrelse Introduktion og formål: Det er velkendt, at tandlæger kan spille en rolle i forhold til tidlig identifikation af en spiseforstyrrelse. Der erimidlertid begrænset viden om, hvilke forventninger tandlæger og personer med en spiseforstyrrelse har...... til mødet med hinanden i klinikken, og hvordan dette opleves. Undersøgelsens formål var derfor at få viden om mødet mellem tandlæger og personer med en spiseforstyrrelse. Materialer og metoder: Undersøgelsen var en tværsnitsundersøgelse baseret på to spørgeskemaer udarbejdet til henholdsvis tandlæger...... og personer med en spiseforstyrrelse. I alt 1.405 tandlæger deltog, mens 260 personer med en spiseforstyrrelse besvarede spørgeskemaet. Resultater: Tandlægerne havde større selvrapporteret viden om orale komplikationer ved en spiseforstyrrelse end om spiseforstyrrelser generelt. Størstedelen af...

MED23-associated Intellectual Disability in a Non-consanguineous Family

OpenAIRE

Trehan, Aditi; Brady, Jacqueline M.; Maduro, Valerie; Bone, William; Huang, Yan; Golas, Gretchen A.; Kane, Megan; Lee, Paul R.; Thurm, Audrey; Gropman, Andrea L.; Paul, Scott M.; Vezina, Gilbert; Markello, Thomas C.; Gahl, William A.; Boerkoel, Cornelius F.

2015-01-01

Intellectual disability (ID) is a heterogeneous condition arising from a variety of environmental and genetic factors. Among these causes are defects in transcriptional regulators. Herein, we report two brothers in a non-consanguineous family with novel compound heterozygous, disease-segregating mutations (NM_015979.3: [3656A>G];[4006C>T], NP_057063.2: [H1219R];[R1336X]) in MED23. This gene encodes a subunit of the Mediator complex that modulates the expression of RNA polymerase II-dependent ...

Lyden Sker - et interview med Torben Ulrich og Søren Kjærgaard

DEFF Research Database (Denmark)

Kristensen, Thomas Bjørnsten

2009-01-01

Da musikeren, poeten og tennisspilleren Torben Ulrich i Seattle mødte jazzpianisten og komponisten Søren Kjærgaard udviklede det sig til en dybdegående udforskning af feltet mellem lyd og ord, stilhed og puls, rum og nærvær. Deres fælles bestræbelser kulminerede i foråret 2009 med det eksperiment......Da musikeren, poeten og tennisspilleren Torben Ulrich i Seattle mødte jazzpianisten og komponisten Søren Kjærgaard udviklede det sig til en dybdegående udforskning af feltet mellem lyd og ord, stilhed og puls, rum og nærvær. Deres fælles bestræbelser kulminerede i foråret 2009 med det...

Sammensvorne designere med succes

DEFF Research Database (Denmark)

Dickson, Thomas

2005-01-01

Den danske tegnestue Komplot Design har for nylig oplevet den ære, at to af deres stole bliver brugt i cafeerne på det nyindrettede Museum of Modern Art i New York. Men det er ikke kun med møbler, de har succes - tegnestuen kaster sig med iver over mange slags produkter.......Den danske tegnestue Komplot Design har for nylig oplevet den ære, at to af deres stole bliver brugt i cafeerne på det nyindrettede Museum of Modern Art i New York. Men det er ikke kun med møbler, de har succes - tegnestuen kaster sig med iver over mange slags produkter....

Processeringsoptimering med Canons software

DEFF Research Database (Denmark)

Precht, Helle

2009-01-01

. Muligheder i software optimering blev studeret i relation til optimal billedkvalitet og kontrol optagelser, for at undersøge om det var muligt at acceptere diagnostisk billedkvalitet og derved tage afsæt i ALARA. Metode og materialer Et kvantitativt eksperimentelt studie baseret på forsøg med teknisk og...... humant fantom. CD Rad fantom anvendes som teknisk fantom, hvor billederne blev analyseret med CD Rad software, og resultatet var en objektiv IQF værdi. Det humane fantom var et lamme pelvis med femur, der via NRPB’ er sammenlignelig med absorptionen ved et femårigt barn. De humane forsøgsbilleder blev...

Predicting clicks of PubMed articles.

Science.gov (United States)

Mao, Yuqing; Lu, Zhiyong

2013-01-01

Predicting the popularity or access usage of an article has the potential to improve the quality of PubMed searches. We can model the click trend of each article as its access changes over time by mining the PubMed query logs, which contain the previous access history for all articles. In this article, we examine the access patterns produced by PubMed users in two years (July 2009 to July 2011). We explore the time series of accesses for each article in the query logs, model the trends with regression approaches, and subsequently use the models for prediction. We show that the click trends of PubMed articles are best fitted with a log-normal regression model. This model allows the number of accesses an article receives and the time since it first becomes available in PubMed to be related via quadratic and logistic functions, with the model parameters to be estimated via maximum likelihood. Our experiments predicting the number of accesses for an article based on its past usage demonstrate that the mean absolute error and mean absolute percentage error of our model are 4.0% and 8.1% lower than the power-law regression model, respectively. The log-normal distribution is also shown to perform significantly better than a previous prediction method based on a human memory theory in cognitive science. This work warrants further investigation on the utility of such a log-normal regression approach towards improving information access in PubMed.

Tungmetaller i korn Undersøkelser av prøver dyrket før 1945 sammenlignet med prøver fra 197 6

OpenAIRE

Selmer-Olsen, A. R.

1986-01-01

Hvete, havre og bygg fra 1930, 1931 og 1943 er analysert på en del tungmetaller og resultatene er sammenlignet med korn dyrket i 1976. Materialet er altfor spinkelt til å trekke noen konklusjon, men antydningsvis kan det se ut som om tungmetallnivået i hvete og bygg ikke er høyere nå enn det var før 1945. Innholdet i havre derimot kan se ut som om det har øket litt. Generelt kan det se ut som om havre har et litt høyere nivå enn de andre.

PubMed-EX: a web browser extension to enhance PubMed search with text mining features.

Science.gov (United States)

Tsai, Richard Tzong-Han; Dai, Hong-Jie; Lai, Po-Ting; Huang, Chi-Hsin

2009-11-15

PubMed-EX is a browser extension that marks up PubMed search results with additional text-mining information. PubMed-EX's page mark-up, which includes section categorization and gene/disease and relation mark-up, can help researchers to quickly focus on key terms and provide additional information on them. All text processing is performed server-side, freeing up user resources. PubMed-EX is freely available at http://bws.iis.sinica.edu.tw/PubMed-EX and http://iisr.cse.yzu.edu.tw:8000/PubMed-EX/.

Udkantsdanmark: Avisernes (med)produktion af Nordjyllands territorielle stigma

DEFF Research Database (Denmark)

Pristed Nielsen, Helene; Christensen, Sascha

2013-01-01

Artiklen undersøger hvordan Region Nordjylland (NJ) beskrives i medierne og hvordan diskursen om Udkanten dominerer avisernes fremstilling af regionen . Baggrunden herfor er en interesse for social ulighed, og i denne sammenhæng Wacquants begreb om territorielt stigma (1996, 2007). Wacquant føjer...... stigma. I Gunnar Lind Haase Svendsens studie af italesættelsen af ’udkanten’ fra 1996-2011 ses fx en gennem de seneste år stigende anvendelse af termer som ’den rådne banan’ og ’Udkantsdanmark’ i medierne (Svendsen 2013: 12). Dette stigma forbindes med flere dele af Danmark (se bl.a. Arbejderbevægelsens...

Når tælleriet løber af med os

DEFF Research Database (Denmark)

Nielsen, Gritt B.; Sarauw, Laura Louise

2014-01-01

Studiefremdriftsreformen kan ses som en slags omvendt motorvejslogik, hvor de studerende belønnes for at køre (for) stærkt. Samtidig er den anvendte kilometerenhed, det såkaldte ECTS-system (European Credit Transfer System), en rent kvantitativ logik. Den måler med andre ord ikke det faglige niveau...... eller sværhedsgrad, men den tid, de studerende (teoretisk set) forventes at bruge på et forløb. Kravet om en minimumakkumulation af 60 ECTS-point årligt betyder således, at studerende på tværs af fag vil skulle bevæge sig igennem uddannelsessystemet i samme tempo og takt. Tid bliver hermed en faktor...

In-flight measurements and RCS-predictions: A comparison on broad-side radar range profiles of a Boeing 737

NARCIS (Netherlands)

Heiden, R. van der; Ewijk, L.J. van; Groen, F.C.A.

1997-01-01

The validation of Radar Cross Section (RCS) prediction techniques against real measurements is crucial to acquire confidence in predictions when measurements are not available. In this paper we present the first results of a comparison on one dimensional images, i.e., radar range profiles. The

Liquid viscosity of low-GWP refrigerant mixtures (R32 + R1234yf) and (R125 + R1234yf)

International Nuclear Information System (INIS)

Dang, Yagu; Kamiaka, Takumi; Dang, Chaobin; Hihara, Eiji

2015-01-01

Highlights: • We measured liquid viscosity of low GWP refrigerant R1234yf binary mixtures. • Viscosity of R1234yf mixtures were correlated with the roughness hard-sphere method. • Viscosity of R1234yf mixtures were correlated with the Grunberg and Nissan method. - Abstract: In this work, the viscosity of R1234yf, (R32 + R1234yf), and (R125 + R1234yf) in one-phase liquid was measured. The combined expanded uncertainty of viscosity measurement apparatus of confidence of 0.95 (k = 2) is about 2.0%. The measurements of mixtures containing (30.0, 50.0, and 70.0) wt% R32 or R125 were carried out between T = (283.0 and 323.0) K (at intervals of T = 5 K) and P = (1.58 and 2.74) MPa, with a moving piston viscometer (VISCOpro 1600, accuracy ±1.0%) and a Coriolis flowmeter (Ultramass MKII, accuracy ±0.001 g/ml). The measured data were correlated with a hard-sphere (RSH) method and the Grunberg and Nissan method. The average absolute deviations are (2.2 and 3.3)% for the (R32 + R1234yf) and (R125 + R1234yf) mixtures by RSH method, (2.8 and 1.3)% for the (R32 + R1234yf) and (R125 + R1234yf) mixtures by Grunberg and Nissan method, while (3.5 and 2.4)% for the (R32 + R1234yf) and (R125 + R1234yf) mixtures by RefProp V9.1, respectively

Survey Method for Radiological Surveys of 300-FF-1 Operable Unit Soils and Material

International Nuclear Information System (INIS)

Brehm, D.M.

1998-06-01

This technical basis is to be used to survey soils at the 300-FF-1 Operable Unit during remediation of the site. Its purpose is to provide a basis for the survey methods to be employed by radiological control technician (RCTs) to guide the excavation effort in accordance with the 300-FF-1 waste site Record of Decision (ROD). The ROD for the 300-FF-1 Operable Unit requires selective excavation, removal, and disposal of contaminated soil above 350 pCi/g total uranium activity. Soil above this level will be disposed of as radioactive waste. The remaining soil will remain onsite

Isothermal (vapour + liquid) equilibrium for the binary {l_brace}1,1,2,2-tetrafluoroethane (R134) + propane (R290){r_brace} and {l_brace}1,1,2,2-tetrafluoroethane (R134) + isobutane (R600a){r_brace} systems

Energy Technology Data Exchange (ETDEWEB)

Dong Xueqiang [Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, P.O. Box 2711, Beijing 100190 (China); Graduate University of Chinese Academy of Sciences, Beijing 100039 (China); Gong Maoqiong, E-mail: gongmq@mail.ipc.ac.c [Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, P.O. Box 2711, Beijing 100190 (China); Liu Junsheng [Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, P.O. Box 2711, Beijing 100190 (China); Graduate University of Chinese Academy of Sciences, Beijing 100039 (China); Wu Jianfeng, E-mail: jfwu@mail.ipc.ac.c [Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, P.O. Box 2711, Beijing 100190 (China)

2010-09-15

(Vapour + liquid) equilibrium (VLE) data for the binary systems of {l_brace}1,1,2,2-tetrafluoroethane (R134) + propane (R290){r_brace} and {l_brace}1,1,2,2-tetrafluoroethane (R134) + isobutane (R600a){r_brace} were measured with a recirculation method at the temperatures ranging from (263.15 to 278.15) K and (268.15 to 288.15) K, respectively. All of the data were correlated by the Peng-Robinson (PR) equation of state (EoS) with the Huron-Vidal (HV) mixing rules utilizing the non-random two-liquid (NRTL) activity coefficient model. Good agreement can be found between the experimental data and the correlated results. Azeotropic behaviour can be found at the measured temperature ranges for these two mixtures.

Musik og billeddannelse (GIM med PTSD-ramte flygtninge: Introduktion til tre single case-studier

Directory of Open Access Journals (Sweden)

Bolette Daniels Beck

2016-12-01

Full Text Available Mange flygtninge kommer fra kulturer med helt andre forestillinger og begreber om årsager til og forventninger om behandling af psykisk lidelse end man almindeligvis anvender i psykiatrien. F.eks. er psykisk lidelse i mange mellemøstlige kulturer forbundet med skam, og udtrykkes måske derfor snarere i form af fysisk smerte. For at et behandlingsforløb skal lykkes, er der behov for kulturel sensitivitet hos behandleren, når der skal samarbejdes med tolken, skabes et møde på tværs af kulturer samt etableres en fælles forståelse af behandlingens formål og proces.

The Wheat Mediator Subunit TaMED25 Interacts with the Transcription Factor TaEIL1 to Negatively Regulate Disease Resistance against Powdery Mildew.

Science.gov (United States)

Liu, Jie; Zhang, Tianren; Jia, Jizeng; Sun, Jiaqiang

2016-03-01

Powdery mildew, caused by the biotrophic fungal pathogen Blumeria graminis f. sp. tritici, is a major limitation for the production of bread wheat (Triticum aestivum). However, to date, the transcriptional regulation of bread wheat defense against powdery mildew remains largely unknown. Here, we report the function and molecular mechanism of the bread wheat Mediator subunit 25 (TaMED25) in regulating the bread wheat immune response signaling pathway. Three homoalleles of TaMED25 from bread wheat were identified and mapped to chromosomes 5A, 5B, and 5D, respectively. We show that knockdown of TaMED25 by barley stripe mosaic virus-induced gene silencing reduced bread wheat susceptibility to the powdery mildew fungus during the compatible plant-pathogen interaction. Moreover, our results indicate that MED25 may play a conserved role in regulating bread wheat and barley (Hordeum vulgare) susceptibility to powdery mildew. Similarly, bread wheat ETHYLENE INSENSITIVE3-LIKE1 (TaEIL1), an ortholog of Arabidopsis (Arabidopsis thaliana) ETHYLENE INSENSITIVE3, negatively regulates bread wheat resistance against powdery mildew. Using various approaches, we demonstrate that the conserved activator-interacting domain of TaMED25 interacts physically with the separate amino- and carboxyl-terminal regions of TaEIL1, contributing to the transcriptional activation activity of TaEIL1. Furthermore, we show that TaMED25 and TaEIL1 synergistically activate ETHYLENE RESPONSE FACTOR1 (TaERF1) transcription to modulate bread wheat basal disease resistance to B. graminis f. sp. tritici by repressing the expression of pathogenesis-related genes and deterring the accumulation of reactive oxygen species. Collectively, we identify the TaMED25-TaEIL1-TaERF1 signaling module as a negative regulator of bread wheat resistance to powdery mildew. © 2016 American Society of Plant Biologists. All Rights Reserved.

Frontal cortex and hippocampus neurotransmitter receptor complex level parallels spatial memory performance in the radial arm maze.

Science.gov (United States)

Shanmugasundaram, Bharanidharan; Sase, Ajinkya; Miklosi, András G; Sialana, Fernando J; Subramaniyan, Saraswathi; Aher, Yogesh D; Gröger, Marion; Höger, Harald; Bennett, Keiryn L; Lubec, Gert

2015-08-01

Several neurotransmitter receptors have been proposed to be involved in memory formation. However, information on receptor complexes (RCs) in the radial arm maze (RAM) is missing. It was therefore the aim of this study to determine major neurotransmitter RCs levels that are modulated by RAM training because receptors are known to work in homo-or heteromeric assemblies. Immediate early gene Arc expression was determined by immunohistochemistry to show if prefrontal cortices (PFC) and hippocampi were activated following RAM training as these regions are known to be mainly implicated in spatial memory. Twelve rats per group, trained and untrained in the twelve arm RAM were used, frontal cortices and hippocampi were taken, RCs in membrane protein were quantified by blue-native PAGE immunoblotting. RCs components were characterised by co-immunoprecipitation followed by mass spectrometrical analysis and by the use of the proximity ligation assay. Arc expression was significantly higher in PFC of trained as compared to untrained rats whereas it was comparable in hippocampi. Frontal cortical levels of RCs containing AMPA receptors GluA1, GluA2, NMDA receptors GluN1 and GluN2A, dopamine receptor D1, acetylcholine nicotinic receptor alpha 7 (nAChR-α7) and hippocampal levels of RCs containing D1, GluN1, GluN2B and nAChR-α7 were increased in the trained group; phosphorylated dopamine transporter levels were decreased in the trained group. D1 and GluN1 receptors were shown to be in the same complex. Taken together, distinct RCs were paralleling performance in the RAM which is relevant for interpretation of previous and design of future work on RCs in memory studies. Copyright © 2015 Elsevier B.V. All rights reserved.

Kontaktlærers utfordringer når en elev i klassen dør

OpenAIRE

Nevland, Tiril

2014-01-01

I denne bacheloroppgaven har jeg valgt å skrive om prosessen i en klasse etter en elev i klassen dør, med kontaktlærers utfordringer i fokus. De fleste av oss vil kanskje aldri oppleve det, men hva gjør man om det skjer sin egen klasse? En pult står tom, og vi må som kontaktlærer klare å håndtere situasjonen på en profesjonell måte. Jeg ønsker å finne ut av hvilke utfordringer kontaktlærer kan møte etter en slik tragedie. Med det ønsker jeg å bli bedre forberedt dersom det skjer i min klasse....

»Man tager virkeligheden og gør den til en god historie«

Directory of Open Access Journals (Sweden)

Birgitte Knudsen

2002-09-01

Full Text Available I MedieKultur nr. 30 udskrev redaktionen en konkurrence om »den bedste artikel om Robinson Ekspeditionen.« Deadline for besvarelser var d. 1.1 2001, og Birgitte Knudsens bidrag er belønnet med vin og publicering i dette nummer af MedieKultur, hvor reality-tv er tema. De øvrige artikler om Robinson Ekspeditionen i nærværende nummer er indkommet efter deadline og har ikke deltaget i konkurrencen. Artiklen gennemgår de resultater, som fremkom på baggrund af en undersøgelse af Robinson Ekspeditionen år 2000. Det empiriske grundlag udgøres af to fokusgrupper – begge med stort kendskab til Robinson Ekspeditionen. Analysen viser, at deltagerne i fokusgrup- perne opfatter Robinson Ekspeditionen som et underholdningspro- gram og som et spil. Samtidig opfattes deltagerne i ekspeditionen som virkelige mennesker, som foretager virkelige handlinger, og det betrag- tes hverken som et problem, at TV3 har castet dem som figurer med bestemte karakteristika, eller at programmerne er redigeret på fiktionel- le præmisser. Analysen peger hermed på, at TV3 har indgået en suc- cesfuld dobbelt kontrakt med seriens trofaste seere: det betyder ikke så meget med nuancerne i iscenesættelsesgraden og dermed virke- lighedsreferencen – når bare programmet opfylder sin mission: at un- derholde seeren med intriger og alliancer mellem virkelige mennesker.

Etik och marknadsföring i bloggar : Var går gränsen för smygreklam?

OpenAIRE

Hellman, Anna

2014-01-01

Syftet med detta examensarbete är att belysa marknadsföringen i bloggar och dess etiska problem. Avsikten är att redogöra för var gränsen för smygreklam går och att få reda på hur mycket bloggarna känner till om ämnet. Bloggarnas andel av sociala medier samt mängden bloggläsare har vuxit explosionsartat. Marknadsföring och reklam i soci-ala medier har vuxit i och med populariteten av sociala medier bland folket. På grund av den ökade marknadsföringen i bloggar har smygreklam uppstått. Efterso...

Solution Structure of the N-Terminal Domain of Mediator Subunit MED26 and Molecular Characterization of Its Interaction with EAF1 and TAF7.

Science.gov (United States)

Lens, Zoé; Cantrelle, François-Xavier; Peruzzini, Riccardo; Hanoulle, Xavier; Dewitte, Frédérique; Ferreira, Elisabeth; Baert, Jean-Luc; Monté, Didier; Aumercier, Marc; Villeret, Vincent; Verger, Alexis; Landrieu, Isabelle

2017-10-13

MED26 is a subunit of Mediator, a large complex central to the regulation of gene transcription by RNA Polymerase II. MED26 plays a role in the switch between the initiation and elongation phases of RNA Polymerase II-mediated transcription process. Regulation of these steps requires successive binding of MED26 N-terminal domain (NTD) to TATA-binding protein-associated factor 7 (TAF7) and Eleven-nineteen lysine-rich in leukemia-Associated Factor 1 (EAF1). In order to investigate the mechanism of regulation by MED26, MED26-NTD structure was solved by NMR, revealing a 4-helix bundle. EAF1 (239-268) and TAF7 (205-235) peptide interactions were both mapped to the same groove formed by H3 and H4 helices of MED26-NTD. Both interactions are characterized by dissociation constants in the 10-μM range. Further experiments revealed a folding-upon-binding mechanism that leads to the formation of EAF1 (N247-S260) and TAF7 (L214-S227) helices. Chemical shift perturbations and nuclear Overhauser enhancement contacts support the involvement of residues I222/F223 in anchoring TAF7 helix to a hydrophobic pocket of MED26-NTD, including residues L48, W80 and I84. In addition, Ala mutations of charged residues located in the C-terminal disordered part of TAF7 and EAF1 peptides affected the binding, with a loss of affinity characterized by a 10-time increase of dissociation constants. A structural model of MED26-NTD/TAF7 complex shows bi-partite components, combining ordered and disordered segments, as well as hydrophobic and electrostatic contributions to the binding. This study provides molecular detail that will help to decipher the mechanistic basis for the initiation to elongation switch-function mediated by MED26-NTD. Copyright © 2017 Elsevier Ltd. All rights reserved.

Relevansen af nyere psykodynamisk teori for det klinisk musikterapeutiske arbejde med psykiatriske patienter med personlighedsforstyrrelser

DEFF Research Database (Denmark)

Hannibal, Niels

2007-01-01

Denne artikel beskriver et rationale for anvendelse af musik i en psykoterapeutisk kontekst. Det eksplicitte og implicitte forandringsniveau i psykoterapi med patienter med borderline-personlighedsforstyrrelse (BPF) diskuteres herpå med henvisning til to forskellige syn på terapeutisk forandring:...

Fate and transport of radionuclides in soil-water environment. Review.

Science.gov (United States)

Konoplev, Aleksei

2017-04-01

The ease in which radionuclides move through the environment and are taken up by plants and animals is governed by their chemical forms and by site-specific environmental characteristics. The objective of this paper is to review basic mechanisms of the behavior of radiocesium and radiostrontium in the environment after the nuclear accident. Our understanding of radionuclide's speciation and migration processes seems to be adequate and explains similarities and differences of radiocesium (r-Cs) behavior in the environment after Fukushima and Chernobyl accidents. Climate and geographical conditions in Fukushima Prefecture of Japan and Chernobyl's near-field zone are obviously different. In particular, precipitation differs substantially, with the annual average for Fukushima being about 3 times higher than at Chernobyl. The landscapes and soils also differ significantly. What is more, the speciation of r-Cs in the releases was distinct (large fraction of radionuclides was deposited as fuel particles in 30-km zone around Chernobyl NPP, while in Fukushima radiocesium is mostly part of condensation particles including glassy hot particles). Radiocesium (r-Cs) in the environment is strongly bound to soil and sediment particles containing micaceous clay minerals (illite, vermiculite, etc.), which is associated with two basic processes - high selective reversible sorption and fixation. The r-Cs distribution coefficient Kd in Fukushima rivers was found to be 1-2 orders of magnitude higher than corresponding values for rivers and surface runoff of Chernobyl area. This is indicative of higher ability of Fukushima soils and sediments to bind r-Cs. Dissolved r-Cs wash-off for Fukushima river watersheds is essentially slower than those for Chernobyl. However, steeper slopes and higher precipitation in Fukushima area cause higher erosion and higher particulate r-Cs wash-off. For a comparable time after the accident the total r-Cs wash-off from contaminated catchments in Fukushima

Barns kommunikasjon med ulike typer kart - en progressiv tilnærming til kartlesing

Directory of Open Access Journals (Sweden)

Trine Bjerva

2011-11-01

Full Text Available Utgangspunktet for denne studien er en erkjennelse av hvor vanskelig det kan være for barn å samhandle med det symbolske kartet. Hovedmålet for prosjektet var å utvikle sikrere viten om hvordan barn kommuniserer med ulike typer kart. Det er utarbeidet en modell (Bjerva, Græsli, & Sigurjónsson, 2010 som viser hvordan vi kan utvikle ferdigheten kartlesing hos barn. Vi har undersøkt 106 barn i alderen 3 til 12 år om hvordan de mestrer direkte representasjoner (detaljfoto og perspektiv representasjoner (håndtegnet skråkart. Forskningsdesignet har en økologisk tilnærming hvor datainnsamlingen har foregått i terrenget. Resultatene indikerer at selv små barn mestrer antatt kompliserte oppgaver når de blir presentert for enkle hjelpemidler.

Lær Nemt! Organisation

DEFF Research Database (Denmark)

Lægaard, Jørgen

Her er bogen, som giver dig overblikket over organisationsteorier lige fra Schein til Mintzberg og mange flere - teoretikere, som op gennem de seneste 100 år, har præget organisationsteori. Med dette kompendium får du en dansk fremstilling af organisationsbegrebets teoretiske landskab og får...

STS-46 Atlantis', OV-104's, vertical tail and OMS pods lit up by RCS jet firing

Science.gov (United States)

1992-01-01

STS-46 Atlantis', Orbiter Vehicle (OV) 104's, vertical tail and orbital maneuvering system (OMS) pods are highlighted by the glow of the reaction control system (RCS) jet firings. OV-104 was at an altitude of 128 nautical miles. The remote manipulator system (RMS) arm is partially visible stowed along the port side sill longeron.

THE 300 km s–1 STELLAR STREAM NEAR SEGUE 1: INSIGHTS FROM HIGH-RESOLUTION SPECTROSCOPY OF ITS BRIGHTEST STAR

International Nuclear Information System (INIS)

Frebel, Anna; Casey, Andrew R.; Lunnan, Ragnhild; Norris, John E.; Wyse, Rosemary F. G.; Gilmore, Gerard

2013-01-01

We present a chemical abundance analysis of 300S-1, the brightest likely member star of the 300 km s –1 stream near the faint satellite galaxy Segue 1. From a high-resolution Magellan/MIKE spectrum, we determine a metallicity of [Fe/H] = –1.46 ± 0.05 ± 0.23 (random and systematic uncertainties) for star 300S-1, and find an abundance pattern similar to typical halo stars at this metallicity. Comparing our stellar parameters to theoretical isochrones, we estimate a distance of 18 ± 7 kpc. Both the metallicity and distance estimates are in good agreement with what can be inferred from comparing the Sloan Digital Sky Survey photometric data of the stream stars to globular cluster sequences. While several other structures overlap with the stream in this part of the sky, the combination of kinematic, chemical, and distance information makes it unlikely that these stars are associated with either the Segue 1 galaxy, the Sagittarius Stream, or the Orphan Stream. Streams with halo-like abundance signatures, such as the 300 km s –1 stream, present another observational piece for understanding the accretion history of the Galactic halo.

Folkeretlige problemstillinger i forbindelse med konflikten mellem Ukraine og Rusland

DEFF Research Database (Denmark)

Buhl, Kenneth Øhlenschlæger

Konflikten mellem Ukraine og Rusland udgør en trussel mod den internationale retsorden og dermed også hele den europæiske orden. Med henblik på at give et grundlag for at forstå omfanget af dette aspekt af konflikten behandles her lovligheden af nogle af de handlinger, som har været konfliktens...

Behavior and mortality of free-ranging raccoons, snowshoe hares, and striped skunks after exposure to 300 R γ radiation

International Nuclear Information System (INIS)

Tester, J.R.; Ternes, J.W.; Siniff, D.B.

1977-01-01

Free-ranging raccoons (Procyon lotor), snowshoe hares (Lepus americanus), and striped skunks (Mephitis mephitis) exposed to 300 R cesium-137 radiation were monitored by an automatic radio-tracking system. Five irradiated juvenile raccoons died within 30 days postirradiation, but no controls died. One irradiated and one control snowshoe hare were killed by predators within 30 days after irradiation. No skunks died. No consistent patterns of effects of the irradiation were detected in terms of size or location of home range or in the circadian rhythms

Morphological and functional rescue in RCS rats after RPE cell line transplantation at a later stage of degeneration.

Science.gov (United States)

Wang, Shaomei; Lu, Bin; Girman, Sergej; Holmes, Toby; Bischoff, Nicolas; Lund, Raymond D

2008-01-01

It is well documented that grafting of cells in the subretinal space of Royal College of Surgeons (RCS) rats limits deterioration of vision and loss of photoreceptors if performed early in postnatal life. What is unclear is whether cells introduced later, when photoreceptor degeneration is already advanced, can still be effective. This possibility was examined in the present study, using the human retinal pigment epithelial cell line, ARPE-19. Dystrophic RCS rats (postnatal day [P] 60) received subretinal injection of ARPE-19 cells (2 x 10(5)/3 microL/eye). Spatial frequency was measured by recording optomotor responses at P100 and P150, and luminance threshold responses were recorded from the superior colliculus at P150. Retinas were stained with cresyl violet, retinal cell-specific markers, and a human nuclear marker. Control animals were injected with medium alone. Animals comparably treated with grafts at P21 were available for comparison. All animals were treated with immunosuppression. Later grafts preserved both spatial frequency and threshold responses over the control and delayed photoreceptor degeneration. There were two to three layers of rescued photoreceptors even at P150, compared with a scattered single layer in sham and untreated control retinas. Retinal cell marker staining showed an orderly array of the inner retinal lamination. The morphology of the second-order neurons was better preserved around the grafted area than in regions distant from graft. Sham injection had little effect in rescuing the photoreceptors. RPE cell line transplants delivered later in the course of degeneration can preserve not only the photoreceptors and inner retinal lamination but also visual function in RCS rats. However, early intervention can achieve better rescue.

A systematic analysis of host factors reveals a Med23-interferon-λ regulatory axis against herpes simplex virus type 1 replication.

Science.gov (United States)

Griffiths, Samantha J; Koegl, Manfred; Boutell, Chris; Zenner, Helen L; Crump, Colin M; Pica, Francesca; Gonzalez, Orland; Friedel, Caroline C; Barry, Gerald; Martin, Kim; Craigon, Marie H; Chen, Rui; Kaza, Lakshmi N; Fossum, Even; Fazakerley, John K; Efstathiou, Stacey; Volpi, Antonio; Zimmer, Ralf; Ghazal, Peter; Haas, Jürgen

2013-01-01

Herpes simplex virus type 1 (HSV-1) is a neurotropic virus causing vesicular oral or genital skin lesions, meningitis and other diseases particularly harmful in immunocompromised individuals. To comprehensively investigate the complex interaction between HSV-1 and its host we combined two genome-scale screens for host factors (HFs) involved in virus replication. A yeast two-hybrid screen for protein interactions and a RNA interference (RNAi) screen with a druggable genome small interfering RNA (siRNA) library confirmed existing and identified novel HFs which functionally influence HSV-1 infection. Bioinformatic analyses found the 358 HFs were enriched for several pathways and multi-protein complexes. Of particular interest was the identification of Med23 as a strongly anti-viral component of the largely pro-viral Mediator complex, which links specific transcription factors to RNA polymerase II. The anti-viral effect of Med23 on HSV-1 replication was confirmed in gain-of-function gene overexpression experiments, and this inhibitory effect was specific to HSV-1, as a range of other viruses including Vaccinia virus and Semliki Forest virus were unaffected by Med23 depletion. We found Med23 significantly upregulated expression of the type III interferon family (IFN-λ) at the mRNA and protein level by directly interacting with the transcription factor IRF7. The synergistic effect of Med23 and IRF7 on IFN-λ induction suggests this is the major transcription factor for IFN-λ expression. Genotypic analysis of patients suffering recurrent orofacial HSV-1 outbreaks, previously shown to be deficient in IFN-λ secretion, found a significant correlation with a single nucleotide polymorphism in the IFN-λ3 (IL28b) promoter strongly linked to Hepatitis C disease and treatment outcome. This paper describes a link between Med23 and IFN-λ, provides evidence for the crucial role of IFN-λ in HSV-1 immune control, and highlights the power of integrative genome-scale approaches to

A systematic analysis of host factors reveals a Med23-interferon-λ regulatory axis against herpes simplex virus type 1 replication.

Directory of Open Access Journals (Sweden)

Samantha J Griffiths

Full Text Available Herpes simplex virus type 1 (HSV-1 is a neurotropic virus causing vesicular oral or genital skin lesions, meningitis and other diseases particularly harmful in immunocompromised individuals. To comprehensively investigate the complex interaction between HSV-1 and its host we combined two genome-scale screens for host factors (HFs involved in virus replication. A yeast two-hybrid screen for protein interactions and a RNA interference (RNAi screen with a druggable genome small interfering RNA (siRNA library confirmed existing and identified novel HFs which functionally influence HSV-1 infection. Bioinformatic analyses found the 358 HFs were enriched for several pathways and multi-protein complexes. Of particular interest was the identification of Med23 as a strongly anti-viral component of the largely pro-viral Mediator complex, which links specific transcription factors to RNA polymerase II. The anti-viral effect of Med23 on HSV-1 replication was confirmed in gain-of-function gene overexpression experiments, and this inhibitory effect was specific to HSV-1, as a range of other viruses including Vaccinia virus and Semliki Forest virus were unaffected by Med23 depletion. We found Med23 significantly upregulated expression of the type III interferon family (IFN-λ at the mRNA and protein level by directly interacting with the transcription factor IRF7. The synergistic effect of Med23 and IRF7 on IFN-λ induction suggests this is the major transcription factor for IFN-λ expression. Genotypic analysis of patients suffering recurrent orofacial HSV-1 outbreaks, previously shown to be deficient in IFN-λ secretion, found a significant correlation with a single nucleotide polymorphism in the IFN-λ3 (IL28b promoter strongly linked to Hepatitis C disease and treatment outcome. This paper describes a link between Med23 and IFN-λ, provides evidence for the crucial role of IFN-λ in HSV-1 immune control, and highlights the power of integrative genome

Biota of the 300-FF-1 operable unit. [Westinghouse Hanford Company

Energy Technology Data Exchange (ETDEWEB)

Rickard, W.H. Jr.; Fitzner, R.E.; Brandt, C.A.

1990-10-01

This report summarizes Task 5a-2 of the Phase I Remedial Investigation -- Operable Unit Characterization of the 300-FF-1 Operable Unit on the Hanford Site, near Richland, Washington. The ultimate goal of Phase I is to determine the nature and extent of the threat to public health and the environment from releases of hazardous substances from the operable unit. The purpose of Task 5a-2 was to determine what species inhabit the 300-FF-1 Operable Unit and how they use the unit. The focus is on those species listed as endangered or threatened, those that are economically important, or those that constitute significant components of the human food chain. 39 refs., 5 figs., 5 tabs.

MedPAC Data Book

Data.gov (United States)

U.S. Department of Health & Human Services — MedPACs Data Book is the result of discussions with congressional staff members regarding ways that MedPAC can better support them. Some of the information it...

Phase 1 and 2 feasibility study report for the 300-FF-1 Operable Unit

Energy Technology Data Exchange (ETDEWEB)

1993-11-01

The 300-FF-1 Operable Unit (OU) feasibility study (FS) presented in this document completes the FS process only through the first two study phases: Phase I, Remedial Alternatives Development, and Phase II, Remedial Alternatives Screening in accordance with CERCIA guidance for performing Remedial Investigations and Feasibility Studies (RI/FS) (EPA 1988a). This Phase I/II study provides a generalized view of workable remedial technologies as applied to the site contamination problems as a whole. Phase III, Detailed Analysis of Alternatives, will be performed at a later date to further evaluate screened alternatives based on the nine criteria in the CERCLA RI/FS guidance. The purpose of this Phase I/II FS is to develop and screen a range of alternatives for remediation of contamination present in the vadose zone of the 300-FF-1 OU. The scope of work for this Phase I/II FS includes five primary tasks: 1. Review existing documents and their associated data from relevant investigations and studies; 2. Establish remedial action objectives (RAO) and general response actions (GRA); 3. Identify applicable or relevant and appropriate requirements (ARARS) pertinent to all general response actions (including waste disposal); 4. Develop remedial alternatives (Phase I) applicable to the 300-FF-1 OU including identification and screening of technologies and process options, and assembly of remedial alternatives from representative technology types; 5. Screen alternatives (Phase II) developed in Phase I for implementability, effectiveness, and cost to identify those alternatives which warrant advancement to the detailed analysis phase (Phase III) of the FS.

Development of the SSTL-300-S1 Composite Imager Barrel Structure

Science.gov (United States)

Hamar, Chris; Wood, Trevor; Alsami, Sami; Hallett, Ben

2014-06-01

The SSTL-300-S1 is the latest in the family of highly capable SSTL-300 platforms, providing high resolution imagery with all the existing mission performance of the heritage platform. In developing the product, SSTL has had to undertake the development of a composite imager barrel assembly, which forms the payload instrument's primary structure. Working to a nominal schedule of 24 months from requirements definition to structural qualification, the barrel's development philosophy has had to carefully balance the interdependent optical, structural and programmatic requirements. This paper provides a brief summary description of that development.

7 CFR 330.300 - Soil from foreign countries or Territories or possessions. 1

Science.gov (United States)

2010-01-01

... 7 Agriculture 5 2010-01-01 2010-01-01 false Soil from foreign countries or Territories or possessions. 1 330.300 Section 330.300 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FEDERAL PLANT PEST REGULATIONS; GENERAL; PLANT PESTS; SOIL, STONE, AND QUARRY...

Leg med vision

DEFF Research Database (Denmark)

Munk, Mette; Bertelsen, Katrine

2011-01-01

Bogen henvender sig primært til det pædagogiske personale med målgruppen daginstitutioner. Bogen skal stimulere arbejdet med at gøre bevægelse til en integreret del af kulturen i daginstitutioner - at få det pædagogiske personale til - at sætte ord på og spørgsmålstegn ved deres pædagogiske bevæg...

Hvem er mest fornøyd med samlivet? : samlivskvalitet blant samboere og gifte

OpenAIRE

Wiik, Kenneth Aarskaug; Noack, Turid

2011-01-01

Artiklene i Samfunnsspeilet er tilgjengelige fra SSBs nettsider: http://www.ssb.no/ssp/ Norge og Sverige er land der samboerskap har en lang historie, og der denne samlivsformen er mest utbredt. I dag er et av fire samliv her til lands samboerskap. Men også her er det forskjeller mellom samboere og gifte. Hvis vi sammenlikner samlivskvaliteten blant samboere og gifte, finner vi at unge samboere i alderen 25 til 35 år er minst fornøyd med samlivet sitt. Samboere med planer om å gifte seg me...

Latência e amplitude do P300 auditivo na doença de Alzheimer: uma revisão sistemática P300 latency and amplitude in Alzheimer's disease: a systematic review

Directory of Open Access Journals (Sweden)

Renata Valle Pedroso

2012-08-01

Full Text Available O P300 desempenha um papel fundamental como método de avaliação e monitoramento das demências, entre elas a doença de Alzheimer. OBJETIVO: Realizar uma busca por artigos que analisaram os valores de latência e amplitude de P300 na doença de Alzheimer. MÉTODOS: Foi realizada uma busca nas seguintes bases de dados: Web of Science, PubMed/Medline, Psyc Info, Biological Abstracts e Scielo. Utilizaram-se as seguintes palavras-chave: speed of information processing, speed of processing, information processing, aged, older, elderly, older people, alzheimer dementia, alzheimer disease, Alzheimer, além de referências cruzadas dos artigos selecionados. RESULTADOS: Foram encontrados oito estudos que preencheram os critérios de inclusão adotados para o presente trabalho. Estes estudos mostraram que existe um consenso em relação ao aumento da latência de P300 de idosos com doença de Alzheimer quando comparados com idosos sem a doença. Porém, verifica-se que, com relação à amplitude de P300, ainda não há um consenso, mas, isso pode estar relacionado às diferentes variáveis metodológicas adotadas nos estudos revisados. CONCLUSÃO: Há necessidade de se padronizar as variáveis envolvidas no método de avaliação do P300 para idosos com doença de Alzheimer, para que seja possível comparar os valores de latência e amplitude de P300 dessa população.The P300 plays a key role as a method for monitoring and evaluating dementia, including Alzheimer's disease. OBJECTIVE: The goal of this study was to search for articles which analyzed P300 latency and amplitude values in Alzheimer's disease. METHODS: We searched in the following databases: Web of Science, Pub Med, Psyc Info, Medline, Biological Abstracts and Scielo using the following keywords: speed of information processing, processing speed, information processing, aged, older, elderly, older people, alzheimer dementia, alzheimer disease, Alzheimer and cross-references of selected

34 CFR Appendix E to Part 300 - Index for IDEA-Part B Regulations (34 CFR Part 300)

Science.gov (United States)

2010-07-01

... assessments 300.320(a)(6)(i). • State level activities in support of 300.704(b)(4)(x). ACT (Definition) 300.4... definition of “Secondary school” 300.36. • State-level activities regarding charter schools 300.704(b)(4)(ix... determination • Lack of instruction in reading or math (see § 300.306(b)(1)(i), (b)(1)(ii)) • Limited English...

30 år med Musikterapi. Oplevelser, Erfaringer, Visioner

DEFF Research Database (Denmark)

2012-01-01

I anledning af musikterapiuddannelsens 30 års jubilæum har vi opsøgt og interviewet relevante samarbejdspartnere for at få et indblik i, hvordan de opfatter musikterapien. Efter 30 år, hvor vi konstant har arbejdet på at forbedre musikterapiuddannelsen, synes vi nemlig, at det er spændende at und...

Regulation of immune responses in SJL and F1 hybrid mice by gamma-irradiated syngeneic lymphoma cells

International Nuclear Information System (INIS)

Katz, I.R.; Nagase, F.; Bell, M.K.; Ponzio, N.M.; Thorbecke, G.J.

1984-01-01

Syngeneic mixed lymphocyte-stimulating la+ lymphomas of SJL mice [reticulum cell sarcoma(s) (RCS)] were found to modulate immune responses in vivo. Simultaneous injection of 2 X 10(7) gamma-irradiated or glutaraldehyde-fixed RCS cells with the antigen sheep red blood cells (SRBC) or 2,4,6-trinitrophenol (TNP)-Ficoll markedly suppressed the subsequent plaque-forming cell response in the spleen. The suppression of the anti-SRBC response was prevented by pretreatment of the mice with cyclophosphamide, whereas the suppression of the anti-TNP-Ficoll response was not affected. RCS injection induced high interferon serum titers within 24 hours after injection, which were not prevented by pretreatment with cyclophosphamide. Injection of gamma-irradiated RCS cells (gamma-RCS) or RCS cell extract 2 days prior to antigen enhanced the anti-SRBC but markedly suppressed the anti- TNP-Ficoll response. Injection of RCS both on day -2 and day 0 enhanced the anti-SRBC response. SJL mice 8-9 months of age showed much less or no suppression when gamma-RCS cells were injected on day 0. Certain F1 hybrids of SJL also showed the gamma-RCS-induced suppression of the anti-SRBC response. Suppression was seen in SJL X BALB.B but not in SJL X BALB/c mice and in SJL X A.TH but not in SJL X A.TL mice, suggesting an I-region effect. F1 hybrids of SJL by B10 background mice showed no significant suppression. Enhancement of the anti-SRBC response by prior injection of gamma-RCS was seen in all F1 hybrid mice examined

Med Kingo på dybt vand

DEFF Research Database (Denmark)

Arndal, Lars Stubbe

2014-01-01

Tag med digteren Thomas Kingo ud på dybt vand i selskab med lektor og mag.art. Lars Arndal, der kaster nye perspektiver på Kingos forlisdigt Hierte-Suk. Arndal kommer hermed også med et bud på, hvordan man som lærer kan invitere eleverne med på opdagelse i digtet...

1 Driftsøkonomi med planlegging 2 Wild reindeer of the Soviet Union

Directory of Open Access Journals (Sweden)

Sven Skjenneberg

1985-05-01

Full Text Available Ansgar J. Kosmo. 1986. "Driftsøkonomi med planlegging". Reindriftsadministrasjonen, Alta. 111s. (Foreligger i januaer 1986. Utgis i samarbeid med Samisk utdanningsråd.E.E. Syroechovskij (ed.. 1984. "Wild reindeer of the Soviet Union". English version by U.S. Department of Interior and National Science Foundation. Lectures presented at a research conference at Dudinka, Taimyr in 1975. 43 lectures , some also with direct importance for the reindeer husbandry.

Surveillance of Strontium-90 in Foods after the Fukushima Daiichi Nuclear Power Plant Accident.

Science.gov (United States)

Nabeshi, Hiromi; Tsutsumi, Tomoaki; Uekusa, Yoshinori; Hachisuka, Akiko; Matsuda, Rieko; Teshima, Reiko

2015-01-01

As a result of the Fukushima Daiichi nuclear power plant (NPP) accident, various radionuclides were released into the environment. In this study, we surveyed strontium-90 ((90)Sr) concentrations in several foodstuffs. Strontium-90 is thought to be the third most important residual radionuclide in food collected after the Fukushima Daiichi, NPP accident after following cesium-137 ((137)Cs) and cesium-134 ((134)Cs). Results of (90)Sr analyses indicated that (90)Sr was detect in 25 of the 40 radioactive cesium (r-Cs) positive samples collected in areas around the Fukushima Daiichi NPP, ranging in distance from 50 to 250 km. R-Cs positive samples were defined as containing both (134)Cs and (137)Cs which are considered to be indicators of the after-effects of the Fukushima Daiichi NPP accident. We also detected (90)Sr in 8 of 13 r-Cs negative samples, in which (134)Cs was not detected. Strontium-90 concentrations in the r-Cs positive samples did not significantly exceed the (90)Sr concentrations in r-Cs negative samples or the (90)Sr concentration ranges in comparable food groups found in previous surveys before the Fukushima Daiichi NPP accident. Thus, (90)Sr concentrations in r-Cs positive samples were indistinguishable from the background (90)Sr concentrations arising from global fallout prior to the Fukushima accident, suggesting that no marked increase of (90)Sr concentrations has occurred in r-Cs positive samples as a result of the Fukushima Daiichi NPP accident.

Hydrologic Tests at Characterization Wells R-9i, R-13, R-19, R-22, and R-31, Revision 1

Energy Technology Data Exchange (ETDEWEB)

S.G.McLin; W.J. Stone

2004-06-01

geologic contact between the Puye fanglomerate and unassigned pumiceous units. The specific capacity analysis of a 12 minute pumping test indicates that the Puye fanglomerates near the R-13 screen have a T of 5269 ft{sup 2}/day and correspond to a hydraulic conductivity (K) of 17.6 ft/day based on a saturated thickness of 300 ft. Characterization well R-19 is located east of firing site IJ in Technical Area (TA) 36 on the mesa between Three-mile and Potrillo Canyons. It was completed at a depth of 1885 ft bgs in April 2000. This well was constructed with two screens positioned above the regional water table and five screens positioned below the regional water table. Only the bottom two screens were tested. Screen 6 is completed at about 1727-1734 ft bgs in Puye fanglomerate, and screen 7 is completed at about 1832-1849 ft bgs in Puye fanglomerate. Specific capacity analysis of the screen 6 data suggests that T is about 6923 ft{sup 2}/day and corresponds to a K of 18.6 ft/day based on a saturated thickness of 373 ft. Specific capacity analysis of the screen 7 data suggests that T is about 8179 ft{sup 2}/day and corresponds to a K of 22.0 ft/day based on a saturated thickness of 373 ft. Characterization well R-22 is located on Mesita del Buey between Canada del Buey and Pajarito Canyons immediately east of Material Disposal Area (MDA) G in TA-54. It was completed at a depth of 1489 ft bgs in October 2000. This well was constructed with five screens positioned at or below the regional water table; however, only screens 2-5 were tested. Screen 1 is completed at the regional water table at about 872-914 ft bgs in Cerros del Rio basalt. Screen 2 is completed at about 947-989 ft bgs in Cerros del Rio basalt. Screen 3 is completed at about 1272-1279 ft bgs in Puye fanglomerate. Screen 4 is completed at about 1378-1452 ft bgs in older basalt. Screen 5 is completed at about 1447-1452 ft bgs in older fanglomerate. Bouwer-Rice analyses of the injection-test recovery data suggest K

An advanced regulator for the helium pressurization systems of the Space Shuttle OMS and RCS

Science.gov (United States)

Wichmann, H.

1973-01-01

The Space Shuttle Orbit Maneuvering System and Reaction Control System are pressure-fed rocket propulsion systems utilizing earth storable hypergolic propellants and featuring engines of 6000 lbs and 900 lbs thrust, respectively. The helium pressurization system requirements for these propulsion systems are defined and the current baseline pressurization systems are described. An advanced helium pressure regulator capable of meeting both OMS and RCS helium pressurization system requirements is presented and its operating characteristics and predicted performance characteristics are discussed.

Engineering description of the OMS/RCS/DAP modes used in the HP-9825A High Fidelity Relative Motion Program (HFRMP)

Science.gov (United States)

Wilson, S. W.

1978-01-01

Simplified mathematical models are reported for the space shuttle's Orbital Maneuvering System (OMS), Reaction Control System (RCS), and on-orbit Digital Autopilot (DAP) that have been incorporated in the High-Fidelity Relative Motion Program (HFRMP) for the HP-9825A desk-top calculator. Comparisons were made between data generated by the HFRMP and by the Space Shuttle Functional Simulator (SSFS), which models the cited shuttle systems in much greater detail. These data include propellant requirements for representative translational maneuvers, rotational maneuvers, and attitude maintenance options. Also included are data relating to on-orbit trajectory deviations induced by RCS translational cross coupling. Potential close-range stationkeeping problems that are suggested by HFRMP simulations of 80 millisecond (as opposed to 40 millisecond) DAP cycle effects are described. The principal function of the HFRMP is to serve as a flight design tool in the area of proximity operations.

Transfer of radiocesium in the fruit tree

International Nuclear Information System (INIS)

Takata, Daisuke

2013-01-01

After Fukushima Nuclear Power Plant Accident (Mar. 2011), the author has investigated the transfer of radiocesium (rCs) mainly in peach trees under the actual and cultivating conditions in Fukushima and Tokyo areas, of which results are given with their discussion herein. There are 2 routes of the transfer through the root absorbing the soil rCs originally fallen on the ground and through the aboveground organs absorbing the directly attached rCs on them. The latter attachment includes one on the old branch and main stem existed before the Accident, and another, on the leaf, young shoot and fruit (pericarp) absent at the Accident. Experimental data of peach tree with/without a ground cover show that in the year of the Accident (2011), rCs transfer in the tree body through the aboveground organs was superior to that through the root, and this was also confirmed in the grape tree. Analysis with the imaging plate revealed that a quite high level of rCs was present in the outer thin layer of the bark and in the lenticel, which was conceived to be the possible route of transfer in the tree body. rCs levels on fresh organs like pericarp were lowered by rinsing, suggesting that the nuclide was movable on the old organs to be transferred in new ones. When the tree grown at the high dose area was dug up for its root to be rinsed and partly cut and then the tree was cultivated in non-contaminated soil, the newly shot root contained the higher level of rCs than the leaf, of which mechanism is under investigation. rCs transfer in the tree from the soil and space, and reverse distribution possibly occur: the both sides are to be further investigated qualitatively and quantitatively. (T.T.)

Med5(Nut1) and Med17(Srb4) Are Direct Targets of Mediator Histone H4 Tail Interactions

Science.gov (United States)

Liu, Zhongle; Myers, Lawrence C.

2012-01-01

The Mediator complex transmits activation signals from DNA bound transcription factors to the core transcription machinery. In addition to its canonical role in transcriptional activation, recent studies have demonstrated that S. cerevisiae Mediator can interact directly with nucleosomes, and their histone tails. Mutations in Mediator subunits have shown that Mediator and certain chromatin structures mutually impact each other structurally and functionally in vivo. We have taken a UV photo cross-linking approach to further delineate the molecular basis of Mediator chromatin interactions and help determine whether the impact of certain Mediator mutants on chromatin is direct. Specifically, by using histone tail peptides substituted with an amino acid analog that is a UV activatible crosslinker, we have identified specific subunits within Mediator that participate in histone tail interactions. Using Mediator purified from mutant yeast strains we have evaluated the impact of these subunits on histone tail binding. This analysis has identified the Med5 subunit of Mediator as a target for histone tail interactions and suggests that the previously observed effect of med5 mutations on telomeric heterochromatin and silencing is direct. PMID:22693636

Mars 2020 Entry, Descent and Landing Instrumentation (MEDLI2)

Science.gov (United States)

Bose, Deepak; Wright, Henry; White, Todd; Schoenenberger, Mark; Santos, Jose; Karlgaard, Chris; Kuhl, Chris; Oishi, TOmo; Trombetta, Dominic

2016-01-01

This paper will introduce Mars Entry Descent and Landing Instrumentation (MEDLI2) on NASA's Mars2020 mission. Mars2020 is a flagship NASA mission with science and technology objectives to help answer questions about possibility of life on Mars as well as to demonstrate technologies for future human expedition. Mars2020 is scheduled for launch in 2020. MEDLI2 is a suite of instruments embedded in the heatshield and backshell thermal protection systems of Mars2020 entry vehicle. The objectives of MEDLI2 are to gather critical aerodynamics, aerothermodynamics and TPS performance data during EDL phase of the mission. MEDLI2 builds up the success of MEDLI flight instrumentation on Mars Science Laboratory mission in 2012. MEDLI instrumentation suite measured surface pressure and TPS temperature on the heatshield during MSL entry into Mars. MEDLI data has since been used for unprecedented reconstruction of aerodynamic drag, vehicle attitude, in-situ atmospheric density, aerothermal heating, transition to turbulence, in-depth TPS performance and TPS ablation. [1,2] In addition to validating predictive models, MEDLI data has highlighted extra margin available in the MSL forebody TPS, which can potentially be used to reduce vehicle parasitic mass. MEDLI2 expands the scope of instrumentation by focusing on quantities of interest not addressed in MEDLI suite. The type the sensors are expanded and their layout on the TPS modified to meet these new objectives. The paper will provide key motivation and governing requirements that drive the choice and the implementation of the new sensor suite. The implementation considerations of sensor selection, qualification, and demonstration of minimal risk to the host mission will be described. The additional challenges associated with mechanical accommodation, electrical impact, data storage and retrieval for MEDLI2 system, which extends sensors to backshell will also be described.

Irantsam pokazali otvet "300 spartantsam"

Index Scriptorium Estoniae

2007-01-01

Ajaloohõnguline sõjafilm "300", mis kujutas Termopüülides 5. saj. e.m.a.pärslaste ja spartalaste vahel toimunud lahingut: režissöör Zack Snyder : Ameerika Ühendriigid 2006. Film kutsus Iraanis esile meelepaha. Loodi dokfilm tõestamaks pärslaste kõrget kultuuritaset filmis kujutatud ajal

Live-innspilling i studio med fokus på akustisk gitar og vokal

OpenAIRE

Lamborg, Kristine; Larsen, Axel Wold

2014-01-01

vår bacheloroppgave foreligger det en teoretisk undersøkelse, samt tre live-innspillinger med artisten Robert Bergstrøm. Vårt mål, i tillegg til å spille inn disse låtene, var å undersøke hvilke faktorer som kunne være med på å påvirke en live-innspilling i studio. Vi kom frem til at små detaljer som for eksempel valg av plekter, justering av mikrofonplassering og slitasje på stemmebåndet kan påvirke en produksjon i stor grad. Videre kom vi frem til at kondensatormikrofoner tilfører et rik...

Herrens röst

DEFF Research Database (Denmark)

Rösing, Lilian Munk

2015-01-01

Om språket är gränsen mellan djur och människor, vad innebär det när hundar talar? I filmen Upp pratar de animerade hundarna, men med sin husses röst. Lilian Munk Rösing ser filmen i sällskap av bland andra Jacques Lacan, Slavoj Žižek och Renata Salecl och finner en röst utan kropp, en kropp besj...

Loss of calretinin immunoreactive fibers in subcortical visual recipient structures of the RCS dystrophic rat.

Science.gov (United States)

Vugler, Anthony A; Coffey, Peter J

2003-11-01

The retinae of dystrophic Royal College of Surgeons (RCS) rats exhibit progressive photoreceptor degeneration accompanied by pathology of ganglion cells. To date, little work has examined the consequences of retinal degeneration for central visual structures in dystrophic rats. Here, we use immunohistochemistry for calretinin (CR) to label retinal afferents in the superior colliculus (SC), lateral geniculate nucleus, and olivary pretectal nucleus of RCS rats aged between 2 and 26 months of age. Early indications of fiber loss in the medial dystrophic SC were apparent between 9 and 13 months. Quantitative methods reveal a significant reduction in the level of CR immunoreactivity in visual layers of the medial dystrophic SC at 13 months (P animals aged 19-26 months the loss of CR fibers in SC was dramatic, with well-defined patches of fiber degeneration predominating in medial aspects of the structure. This fiber degeneration in SC was accompanied by increased detection of cells immunoreactive for CR. In several animals, regions of fiber loss were also found to contain strongly parvalbumin-immunoreactive cells. Loss of CR fibers was also observed in the lateral geniculate nucleus and olivary pretectal nucleus. Patterns of fiber loss in the dystrophic SC compliment reports of ganglion cell degeneration in these animals and the response of collicular neurons to degeneration is discussed in terms of plasticity of the dystrophic visual system and properties of calcium binding proteins.

Hjemtagning af dialysebehandling til grønlandske patienter med kronisk nyresvigt

DEFF Research Database (Denmark)

Kronborg, Christian; Kjær, Trine; Bech, Mickael

en periode på 10 år forventes at medføre ekstraomkostninger på ca. 13,9 millioner kroner sammenlignet med at lade patienterne behandle som nu på Rigshospitalet i København. Det vil altså sige en gennemsnitlig ekstraomkostning på ca. 4 millioner kroner om året. Estimatet er dog påvirkeligt at flere...

Making and Executing Decisions for Safe and Independent Living (MED-SAIL): development and validation of a brief screening tool.

Science.gov (United States)

Mills, Whitney L; Regev, Tziona; Kunik, Mark E; Wilson, Nancy L; Moye, Jennifer; McCullough, Laurence B; Naik, Aanand D

2014-03-01

Older adults prefer to remain in their own homes for as long as possible. The purpose of this article is to describe the development and preliminary validation of Making and Executing Decisions for Safe and Independent Living (MED-SAIL), a brief screening tool for capacity to live safely and independently in the community. Prospective preliminary validation study. Outpatient geriatrics clinic located in a community-based hospital. Forty-nine community-dwelling older adults referred to the clinic for a comprehensive capacity assessment. We examined internal consistency, criterion-based validity, concurrent validity, and accuracy of classification for MED-SAIL. The items included in MED-SAIL demonstrated internal consistency (5 items; α = 0.85). MED-SAIL was significantly correlated with the Independent Living Scales (r = 0.573, p ≤0.001) and instrumental activities of daily living (r = 0.440, p ≤0.01). The Mann-Whitney U test revealed significant differences between the no capacity and partial/full capacity classifications on MED-SAIL (U(48) = 60.5, Z = -0.38, p SAIL as a brief screening tool to identify older adults with impaired capacity for remaining safe and independent in their current living environment. MED-SAIL is useful tool for health and social service providers in the community for the purpose of referral for definitive capacity evaluation. Published by Elsevier Inc.

UOP LDR 300 All Assignments New

OpenAIRE

ADMIN

2018-01-01

UOP LDR 300 All Assignments New Check this A+ tutorial guideline at http://www.ldr300assignment.com/ldr-300-uop/ldr-300-all-assignments-latest For more classes visit http://www.ldr300assignment.com LDR 300 Week 1 Assignment Leadership Assessment (2 Papers) LDR 300 Week 2 Assignment Leadership Theories Matrix (2 Set) LDR 300 Week 2 Assignment Formulating Leadership Part I (2 Papers) LDR 300 Week 3 Assignment Interaction and Influence Amo...

VizieR Online Data Catalog: Young star groups in NGC 300 (Rodriguez+, 2016)

Science.gov (United States)

Rodriguez, M. J.; Baume, G.; Feinstein, C.

2016-08-01

Fundamental characteristics of 1147 young star groups identified in 6 ACS/WFC fields of the galaxy NGC 300. For each group: field of the ACS/WFC, equatorial coordinates, radius, number of stars (the suffix bri indicates bright stars with F555W<25, the suffix dct indicate stars belonging to the decontaminated region, the suffixes blue and red refer to blue and red stars respectively), the magnitude of the brightest star in the group, PDMF slope with its error, and galactocentric distance. (1 data file).

Förvaltningen av en bostadsrättsförening : –en studie med utgångspunkt från medlemmarnas ekonomiska intresse

OpenAIRE

Forsén, Rikard; Andersson, Rickard

2009-01-01

Bakgrund:  Bostadsrätten  utgör  en  alltmer  attraktiv  boendeform  och  dess  främsta  syfte  är  att tillgodose dess medlemmar med ett prisvärt boende. Månadsavgifterna från bostadsrättsförenings medlemmar bidrar  till att alla kostnader  täcks upp och därmed är boendekostnaden beroende av hur bostadsrättsföreningens kostnader hanteras. Denna studie undersöker hur verksamheten  i en bostadsrättsförening är förenlig med att verka för medlemmarnas bästa ekonomiska intresse.   Syfte: Syftet m...

Molecular characterization of the Jatropha curcas JcR1MYB1 gene encoding a putative R1-MYB transcription factor

Directory of Open Access Journals (Sweden)

Hui-Liang Li

2014-09-01

Full Text Available The cDNA encoding the R1-MYB transcription factor, designated as JcR1MYB1, was isolated from Jatropha curcas using rapid amplification of cDNA ends. JcR1MYB1 contains a 951 bp open reading frame that encodes 316 amino acids. The deduced JcR1MYB1 protein was predicted to possess the conserved, 56-amino acid-long DNA-binding domain, which consists of a single helix-turn-helix module and usually occurs in R1-MYBs. JcR1MYB1 is a member of the R1-MYB transcription factor subfamily. A subcellular localization study confirmed the nuclear localization of JcR1MYB1. Expression analysis showed that JcR1MYB1 transcripts accumulated in various examined tissues, with high expression levels in the root and low levels in the stem. JcR1MYB1 transcription was up-regulated by polyethylene glycol, NaCl, and cold treatments, as well as by abscisic acid, jasmonic acid, and ethylene treatment. Analysis of transgenic tobacco plants over-expressing JcR1MYB1 indicates an inportant function for this gene in salt stress.

MiR-223 suppresses cell proliferation by targeting IGF-1R.

Directory of Open Access Journals (Sweden)

Cheng You Jia

Full Text Available To study the roles of microRNA-223 (miR-223 in regulation of cell growth, we established a miR-223 over-expression model in HeLa cells infected with miR-223 by Lentivirus pLL3.7 system. We observed in this model that miR-223 significantly suppressed the proliferation, growth rate, colony formation of HeLa cells in vitro, and in vivo tumorigenicity or tumor formation in nude mice. To investigate the mechanisms involved, we scanned and examined the potential and putative target molecules of miR-223 by informatics, quantitative PCR and Western blot, and found that insulin-like growth factor-1 receptor (IGF-1R was the functional target of miR-223 inhibition of cell proliferation. Targeting IGF-1R by miR-223 was not only seen in HeLa cells, but also in leukemia and hepatoma cells. The downstream pathway, Akt/mTOR/p70S6K, to which the signal was mediated by IGF-1R, was inhibited as well. The relative luciferase activity of the reporter containing wild-type 3'UTR(3'untranslated region of IGF-1R was significantly suppressed, but the mutant not. Silence of IGF-1R expression by vector-based short hairpin RNA resulted in the similar inhibition with miR-223. Contrarily, rescued IGF-1R expression in the cells that over-expressed miR-223, reversed the inhibition caused by miR-223 via introducing IGF-1R cDNA that didn't contain the 3'UTR. Meanwhile, we also noted that miR-223 targeted Rasa1, but the downstream molecules mediated by Rasa1 was neither targeted nor regulated. Therefore we believed that IGF-1R was the functional target for miR-223 suppression of cell proliferation and its downstream PI3K/Akt/mTOR/p70S6K pathway suppressed by miR-223 was by targeting IGF-1R.

I Zarathustras spår

DEFF Research Database (Denmark)

Nordenfors, Ola

2006-01-01

Uppsatsen behandlar Wilhelm Peterson-Bergers djupa och varaktiga förhållande till Friedrich Nietzsches tänkande; särskilt sångerna till Nietzsche-texter. Vidare demonstreras hur P.-B.:s musikaliska uttryckssätt förändras i kontakt med Nietzsches dikter.......Uppsatsen behandlar Wilhelm Peterson-Bergers djupa och varaktiga förhållande till Friedrich Nietzsches tänkande; särskilt sångerna till Nietzsche-texter. Vidare demonstreras hur P.-B.:s musikaliska uttryckssätt förändras i kontakt med Nietzsches dikter....

Human Umbilical Cord Mesenchymal Stem Cells: Subpopulations and Their Difference in Cell Biology and Effects on Retinal Degeneration in RCS Rats.

Science.gov (United States)

Wang, L; Li, P; Tian, Y; Li, Z; Lian, C; Ou, Q; Jin, C; Gao, F; Xu, J-Y; Wang, J; Wang, F; Zhang, J; Zhang, J; Li, W; Tian, H; Lu, L; Xu, G-T

2017-01-01

Human umbilical cord mesenchymal stem cells (hUC-MSCs) are potential candidates for treating retinal degeneration (RD). To further study the biology and therapeutic effects of the hUC-MSCs on retinal degeneration. Two hUC-MSC subpopulations, termed hUC-MSC1 and hUC-MSC2, were isolated by single-cell cloning method and their therapeutic functions were compared in RCS rat, a RD model. Although both subsets satisfied the basic requirements for hUC-MSCs, they were significantly different in morphology, proliferation rate, differentiation capacity, phenotype and gene expression. Furthermore, only the smaller, fibroblast-like, faster growing subset hUC-MSC1 displayed stronger colony forming potential as well as adipogenic and osteogenic differentiation capacities. When the two subsets were respectively transplanted into the subretinal spaces of RCS rats, both subsets survived, but only hUC-MSC1 expressed RPE cell markers Bestrophin and RPE65. More importantly, hUC-MSC1 showed stronger rescue effect on the retinal function as indicated by the higher b-wave amplitude on ERG examination, thicker retinal nuclear layer, and decreased apoptotic photoreceptors. When both subsets were treated with interleukin-6, mimicking the inflammatory environment when the cells were transplanted into the eyes with degenerated retina, hUC-MSC1 expressed much higher levels of trophic factors in comparison with hUC-MSC2. The data here, in addition to prove the heterogeneity of hUC-MSCs, confirmed that the stronger therapeutic effects of hUC-MSC1 were attributed to its stronger anti-apoptotic effect, paracrine of trophic factors and potential RPE cell differentiation capacity. Thus, the subset hUC-MSC1, not the other subset or the ungrouped hUC-MSCs should be used for effective treatment of RD. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Yrkesforberedelse eller fagopplæring med fagbrev? Med design og håndverk som kontekst

Directory of Open Access Journals (Sweden)

Bjørn Magne Aakre

2013-09-01

Full Text Available Artikkelen drøfter forholdet mellom yrkesforberedelse og fagopplæring med utgangspunkt i den kombinerte studieretningen formgivingsfag som ble innført i Norge i 1994. I 2006 ble den delt i et programfag under studiespesialiserende fag, og et nytt yrkesfaglig program med betegnelse design og håndverk. Hvilke interesser lå til grunn for endringene, hvor dyptgripende ble de og hvilke overveieleser kan en gjøre i ettertid om forholdet mellom yrkesforberedelse og fagopplæring? Artikkelen søker å svare på spørsmålene ut fra relevante dokumenter og to kvantitative undersøkelser med elever og lærere som informanter. Artikkelen konkluderer med at innholdet forble nokså likt, antall elever ble halvert og at frafallet økte. Det konkluderes videre med at mange forhold bidrar til å legitimere et fag og dets innhold som henholdsvis skolefag, vitenskapsfag eller yrkesfag. Legitimeringen preges ofte av motstridende motiver og interesser, og sjelden bare faglige begrunnelser.

Tryckhållfasthet för resurssnål betong : Utvärdering i tävling av högsta tryckhållfasthet för resurssnål betong

OpenAIRE

Bashar Basmahji, Johannes; Texén, Stefan

2012-01-01

Betong är vårt vanligaste byggmaterial men cement står globalt sett för 5 % av CO2-emissionerna. Med detta som bakgrund så har CBI Betonginstitutet anordnat en tävling, där målet är att nå den högsta tryckhållfasthet i en resurssnål betong, med enbart 200 kg cement per m3. Syftet med denna rapport är att utvärdera tävlingen, vilket har utförts genom en omfattande litteraturstudie.  En första analys av de olika betongrecepten medförde att olika grupperingar kunde urskiljas. Ur dessa fanns det ...

Redox regulation of the MED28 and MED32 mediator subunits is important for development and senescence.

Science.gov (United States)

Shaikhali, Jehad; Davoine, Céline; Björklund, Stefan; Wingsle, Gunnar

2016-05-01

Mediator is a conserved multi-protein complex that acts as a bridge between promoter-bound transcriptional regulators and RNA polymerase II. While redox signaling is important in adjusting plant metabolism and development, the involvement of Mediator in redox homeostasis and regulation only recently started to emerge. Our previous results show that the MED10a, MED28, and MED32 Mediator subunits form various types of covalent oligomers linked by intermolecular disulfide bonds in vitro. To link that with biological significance we have characterized Arabidopsis med32 and med28 mutants and found that they are affected in root development and senescence, phenotypes possibly associated to redox changes.

Desperate Housewives går amok på kvinderollen

DEFF Research Database (Denmark)

Pedersen, Vibeke