WorldWideScience

Sample records for ratchet type dielectrophoretic

  1. Assessment methods for Bree-type ratcheting without the necessity of linearization of stresses and strains

    International Nuclear Information System (INIS)

    Fujioka, Terutaka

    2015-01-01

    This paper proposes methods for assessing Bree-type ratcheting in a cylinder subjected to constant internal pressure and cyclic thermal loading. The proposed methods are elastic analysis-route and elastic–plastic analysis-route. The former is based on the polynomial approximation of the elastic stress distributions for thermal stresses and the reference stress concept for estimating primary stress. The latter elastic–plastic route method is based on the concept of relative elastic core size. The methods proposed were validated by performing elastic–plastic finite element analyses of a smooth cylinder that exhibited Bree-type ratcheting. - Highlights: • Rationalization of the ratcheting assessment has been made. • The proposed methods include both elastic and elastic-plastic routes. • The elastic route method is based on skeletal point stress by elastic FEA. • The elastic-plastic route is based on elastic core size in elastic-plastic FEA. • These have been validated by elastic-plastic FEA causing Bree-type ratcheting

  2. Quantum ratchets

    OpenAIRE

    Grifoni, Milena

    1997-01-01

    In this thesis, ratchet systems operating in the quantum regime are investigated. Ratchet systems, also known as Brownian motors, are periodic systems presenting an intrinsic asymmetry which can be exploited to extract work out of unbiased forces. As a model for ratchet systems, we consider the motion of a particle in a one-dimensional periodic and asymmetric potential, interacting with a thermal environment, and subject to an unbiased driving force. In quantum ratchets, intrinsic quantum flu...

  3. Ratchetting behavior of type 304 stainless steel at room and elevated temperatures

    International Nuclear Information System (INIS)

    Ruggles, M.; Krempl, E.

    1988-01-01

    The zero-to-tension ratchetting behavior was investigated under uniaxial loading at room temperature and at 550, 600 and 650/degree/ C. In History I the maximum stress level of ratchetting was equal to the stress reached in a tensile test at one percent strain. For History II the maximum stress level was established as the stress reached after a 2100 s relaxation at one percent strain. Significant ratchetting was observed for History I at room temperature but not at the elevated temperatures. The accumulated ratchet strain increases with decreasing stress rate. Independent of the stress rates used insignificant ratchet strain was observed at room temperature for History II. This observation is explained in the context of the viscoplasticity theory based on overstress by the exhaustion of the viscous contribution to the stress during relaxation. The viscous part of the stress is the driving force for the ratchetting in History I. Strain aging is presumably responsible for the lack of short-time inelastic deformation resulting in a nearly rate-independent behavior at the elevated temperatures. 26 refs., 7 figs., 1 tab

  4. Cantilever-type electrode array-based high-throughput microparticle sorting platform driven by gravitation and negative dielectrophoretic force

    International Nuclear Information System (INIS)

    Kim, Youngho; Kim, Byungkyu; Lee, Junghun; Kim, Younggeun; Shin, Sang-Mo

    2011-01-01

    In this paper, we describe a cantilever-type electrode (CE) array-based high-throughput sorting platform, which is a tool used to separate microparticles using gravitation and negative dielectrophoretic (n-DEP) force. This platform consists of meso-size channels and a CE array, which is designed to separate a large number of target particles by differences in their dielectric material properties (DMP) and the weight of the particles. We employ a two-step separation process, with sedimentation as the first step and n-DEP as the second step. In order to differentiate the weight and the DMP of each particle, we employ the sedimentation phenomena in a vertical channel and the CE-based n-DEP in an inclined channel. By using three kinds of polystyrene beads with diameters of 10, 25 and 50 µm, the optimal population (10 7 beads ml −1 ) of particles and the appropriate length (25 mm) of the vertical channel for high performance were determined experimentally. Conclusively, by combining sedimentation and n-DEP schemes, we achieve 74.5, 94.7 and 100% separation efficiency for sorting microparticles with a diameter of 10, 25 and 50 µm, respectively.

  5. Ratchetting strain prediction

    International Nuclear Information System (INIS)

    Noban, Mohammad; Jahed, Hamid

    2007-01-01

    A time-efficient method for predicting ratchetting strain is proposed. The ratchetting strain at any cycle is determined by finding the ratchetting rate at only a few cycles. This determination is done by first defining the trajectory of the origin of stress in the deviatoric stress space and then incorporating this moving origin into a cyclic plasticity model. It is shown that at the beginning of the loading, the starting point of this trajectory coincides with the initial stress origin and approaches the mean stress, displaying a power-law relationship with the number of loading cycles. The method of obtaining this trajectory from a standard uniaxial asymmetric cyclic loading is presented. Ratchetting rates are calculated with the help of this trajectory and through the use of a constitutive cyclic plasticity model which incorporates deviatoric stresses and back stresses that are measured with respect to this moving frame. The proposed model is used to predict the ratchetting strain of two types of steels under single- and multi-step loadings. Results obtained agree well with the available experimental measurements

  6. Design methods for structures under thermal ratchet

    International Nuclear Information System (INIS)

    Branca, T.R.; McLean, J.L.

    1975-01-01

    Previous work on the thermal ratchet analysis of a simple pipe is extended to the case of an intersection of a pipe with a spherical shell. The chosen nozzle configuration is subjected to an internal pressure which remains constant, and a cyclic thermal transient which is representative of the type of transient that might be expected for components of a LMFBR. A number of cross-sections through the nozzle were examined, each yielding a different combination of elastic primary and secondary stress. These stresses, together with their associated cyclic strain growth, as determined from an elastic-plastic-creep analysis of the nozzle, were then plotted on a Miller or Bree-type diagram. Thus, a number of points, one for each cross-section considered, were available for comparison with the data obtained from the ratchet analysis of simple pipe sections. Both the elastic and inelastic analyses on the nozzle were performed using the finite element method of structural analysis of the ANSYS computer code. The pipe ratchetting cases were computed using the Oak Ridge National Laboratory PLACRE code. For a simple pipe ratchet case, a brief comparison is given between the version of ANSYS used in this study, the ANSYS version used in previous work and PLACRE code. The three programs did not yield identical results. Further study is needed to resolve the discrepancies that were observed. The results of the comparison between the nozzle ratchet and pipe ratchet solutions indicate that reasonable predictions can be made for the nozzle ratchet strains based on elastic parameters and design curves developed from pipe ratchetting solutions. (author)

  7. Dielectrophoretic separation of gaseous isotopes

    International Nuclear Information System (INIS)

    McConnell, D.B.

    1975-01-01

    Gaseous isotopes are separated from a mixture in a vertically elongated chamber by subjecting the mixture to a nonuniform transverse electric field. Dielectrophoretic separation of the isotopes is effected, producing a transverse temperature gradient in the chamber, thereby enhancing the separation by convective countercurrent flow. In the example given, the process and apparatus are applied to the production of heavy water from steam

  8. Modelling of ratchetting

    International Nuclear Information System (INIS)

    Geyer, P.; Proix, J.M.; Shoenberger, P.; Taheri, S.

    1993-09-01

    The normal or abnormal operating subjects the nuclear power plant's components to cyclic loading (pressure, temperature gradient). So, we can have a progressive strain accumulation on every cyclic loading. This ratchet (cyclic strain accumulation) can produce excessive deformation or increase some damages as thermal fatigue. For some components, a fine modelling of the material's behaviour is necessary to study their mechanical strength. The modelling of cyclic plasticity made great progress during the past 20 years. The ratchet is one of the last phenomena for which numerical models have to be improved. We give in this paper the present state of research to model the description of ratcheting effects. Then we use the experimental results on the austenitic stainless steel 316L at 20 deg C and 300 deg C to study the TAHERI and the BURLET and CAILLETAUD model's capabilities. The cyclic constitutive law with a discrete memory variable developed by TAHERI leads to a satisfying description of ratcheting phenomena in uniaxial loadings. With the modification of kinematic hardening proposed by Burlet and Cailletaud in the Chaboche model we get a good modelling of ratchet in biaxial loadings. These two models have been integrated into a 3D structural mechanics software, the F.E. code ASTER. We present here the calculation of a tubular structure with a thickness transition subjected to thermal cycling. (authors). 11 figs., 3 tabs., 22 refs

  9. Ratchet due to broken friction symmetry

    DEFF Research Database (Denmark)

    Norden, Bengt; Zolotaryuk, Yaroslav; Christiansen, Peter Leth

    2002-01-01

    A ratchet mechanism that occurs due to asymmetric dependence of the friction of a moving system on its velocity or a driving force is reported. For this kind of ratchet, instead of a particle moving in a periodic potential, the dynamics of which have broken space-time symmetry, the system must...... be provided with sonic internal structure realizing such a velocity- or force-friction dependence. For demonstration of a ratchet mechanism of this type, an experimental setup (gadget) that converts longitudinal oscillating or fluctuating motion into a unidirectional rotation has been built and experiments...... with it have been carried out. In this device, an asymmetry of friction dependence on an applied force appears, resulting in rectification of rotary motion, In experiments, our setup is observed to rotate only in one direction, which is in accordance with given theoretical arguments, Despite the setup being...

  10. Electrodynamic ratchet motor.

    Science.gov (United States)

    Lim, Jiufu; Sader, John E; Mulvaney, Paul

    2009-03-01

    Brownian ratchets produce directed motion through rectification of thermal fluctuations and have been used for separation processes and colloidal transport. We propose a flashing ratchet motor that enables the transduction of electrical energy into rotary micromechanical work. This is achieved through torque generation provided by boundary shaping of equipotential surfaces. The present device contrasts to previous implementations that focus on translational motion. Stochastic simulations elucidate the performance characteristics of this device as a function of its geometry. Miniaturization to nanoscale dimensions yields rotational speeds in excess of 1 kHz, which is comparable to biomolecular motors of similar size.

  11. Quantum ratchets reroute electrons

    International Nuclear Information System (INIS)

    Haenggi, P.; Reimann, P.

    1999-01-01

    Is it possible to extract energy from random fluctuations and put it to use? This challenging question has provoked discussion ever since the early days of Brownian-motion theory. For large-scale or macroscopic fluctuations, the answer is ''yes'' - the principle is demonstrated, for example, in the self-winding wristwatch. Much subtler is the issue of whether microscopic random fluctuations, such as thermal Brownian motion or even the haphazard motion of quantum particles, acting as a random energy source can cause the particles to flow in one direction only. In recent years this field has been the scene of remarkable activity, motivated by the prospect of potentially high-profile technological and biological applications, such as molecular motors. In particular the directed transport of particles in an asymmetric potential known as a ratchet has received a lot of attention. This research, however, has focused on ''thermal ratchets'' in which the particles undergo thermal Brownian motion: the next challenge is to move from the classical world and account for quantum mechanical effects. Recently a collaboration between physicists at Lund University in Sweden and the Niels Bohr Institute in Copenhagen has taken a significant step forward and built a quantum ratchet (H Linke et al. 1998 Europhys. Lett. 44 341 and 45 406). The device is based on an aluminium-doped gallium arsenide (GaAs/AlGaAs) quantum dot with a ratchet-like, triangular-shaped cavity. In this article the authors discuss the implications of this work. (UK)

  12. Implementing Demons and Ratchets

    Directory of Open Access Journals (Sweden)

    Peter M. Orem

    2017-01-01

    Full Text Available Experimental results show that ratchets may be implemented in semiconductor and chemical systems, bypassing the second law and opening up huge gains in energy production. This paper summarizes or describes experiments and results on systems that effect demons and ratchets operating in chemical or electrical domains. One creates temperature differences that can be harvested by a heat engine. A second produces light with only heat input. A third produces harvestable electrical potential directly. These systems share creating particles in one location, destroying them in another and moving them between locations by diffusion (Brownian motion. All absorb ambient heat as they produce other energy forms. None requires an external hot and cold side. The economic and social impacts of these conversions of ambient heat to work are, of course, well-understood and huge. The experimental results beg for serious work on the chance that they are valid.

  13. The Leverage Ratchet Effect

    OpenAIRE

    Anat R. Admati; Peter M. DeMarzo; Martin F. Hellwig; Paul Pfleiderer

    2013-01-01

    Shareholder-creditor conflicts can create leverage ratchet effects, resulting in inefficient capital structures. Once debt is in place, shareholders may inefficiently increase leverage but avoid reducing it no matter how beneficial leverage reduction might be to total firm value. We present conditions for an irrelevance result under which shareholders view asset sales, pure recapitalization and asset expansion with new equity as equally undesirable. We then analyze how seniority, asset hetero...

  14. Magnus-induced ratchet effects for skyrmions interacting with asymmetric substrates

    Science.gov (United States)

    Reichhardt, C.; Ray, D.; Olson Reichhardt, C. J.

    2015-07-01

    We show using numerical simulations that pronounced ratchet effects can occur for ac driven skyrmions moving over asymmetric quasi-one-dimensional substrates. We find a new type of ratchet effect called a Magnus-induced transverse ratchet that arises when the ac driving force is applied perpendicular rather than parallel to the asymmetry direction of the substrate. This transverse ratchet effect only occurs when the Magnus term is finite, and the threshold ac amplitude needed to induce it decreases as the Magnus term becomes more prominent. Ratcheting skyrmions follow ordered orbits in which the net displacement parallel to the substrate asymmetry direction is quantized. Skyrmion ratchets represent a new ac current-based method for controlling skyrmion positions and motion for spintronic applications.

  15. Analytical Formulation of the Electric Field Induced by Electrode Arrays: Towards Automated Dielectrophoretic Cell Sorting

    Directory of Open Access Journals (Sweden)

    Vladimir Gauthier

    2017-08-01

    Full Text Available Dielectrophoresis is defined as the motion of an electrically polarisable particle in a non-uniform electric field. Current dielectrophoretic devices enabling sorting of cells are mostly controlled in open-loop applying a predefined voltage on micro-electrodes. Closed-loop control of these devices would enable to get advanced functionalities and also more robust behavior. Currently, the numerical models of dielectrophoretic force are too complex to be used in real-time closed-loop control. The aim of this paper is to propose a new type of models usable in this framework. We propose an analytical model of the electric field based on Fourier series to compute the dielectrophoretic force produced by parallel electrode arrays. Indeed, this method provides an analytical expression of the electric potential which decouples the geometrical factors (parameter of our system, the voltages applied on electrodes (input of our system, and the position of the cells (output of our system. Considering the Newton laws on each cell, it enables to generate easily a dynamic model of the cell positions (output function of the voltages on electrodes (input. This dynamic model of our system is required to design the future closed-loop control law. The predicted dielectrophoretic forces are compared to a numerical simulation based on finite element model using COMSOL software. The model presented in this paper enables to compute the dielectrophoretic force applied to a cell by an electrode array in a few tenths of milliseconds. This model could be consequently used in future works for closed-loop control of dielectrophoretic devices.

  16. Ratcheting failure of pressurised straight pipes and elbows under reversed bending

    International Nuclear Information System (INIS)

    Vishnuvardhan, S.; Raghava, G.; Gandhi, P.; Saravanan, M.; Goyal, Sumit; Arora, Punit; Gupta, Suneel K.; Bhasin, Vivek

    2013-01-01

    Ratcheting studies were carried out on Type 304LN stainless steel straight pipes and elbows subjected to steady internal pressure and cyclic bending load. The internal pressure for all the straight pipes was 35 MPa and in the case of elbows the internal pressure was varied for different elbows, ranging from 27.6 MPa to 39.2 MPa. Cyclic bending load was applied on the specimens by subjecting them to different levels of load-line displacement. The specimens have undergone significant ratchet swelling (ballooning), ovalization and consequent thinning of the cross-section during ratcheting. The straight pipes failed either by occurrence of through-wall crack accompanied by simultaneous ballooning, or bursting with simultaneous ballooning. All the elbows failed by occurrence of through-wall crack accompanied by simultaneous ballooning. Ratcheting behaviour of straight pipes and elbows were compared and it was generally inferred that ratcheting was more pronounced in straight pipes than in elbows. -- Graphical abstract: Strain history for the specimen QCE-RAT-6-L1. Highlights: • Studies were carried out under combined internal pressure and cyclic bending. • Ratcheting strains were measured at critical locations of the specimens. • Quantified the percentage of ballooning, ovalization and reduction in thickness. • Modes of ratcheting failure of straight pipes and elbows are studied. • Inferred that ratcheting is more pronounced in straight pipes than in elbows

  17. Mixed motion in deterministic ratchets due to anisotropic permeability

    NARCIS (Netherlands)

    Kulrattanarak, T.; Sman, van der R.G.M.; Lubbersen, Y.S.; Schroën, C.G.P.H.; Pham, H.T.M.; Sarro, P.M.; Boom, R.M.

    2011-01-01

    Nowadays microfluidic devices are becoming popular for cell/DNA sorting and fractionation. One class of these devices, namely deterministic ratchets, seems most promising for continuous fractionation applications of suspensions (Kulrattanarak et al., 2008 [1]). Next to the two main types of particle

  18. Dielectrophoretic assembly of carbon nanotube devices

    DEFF Research Database (Denmark)

    Dimaki, Maria

    The purpose of this project has been to assemble single-walled carbon nanotubes on electrodes at the tip of a biocompatible cantilever and use these for chemical species sensing in air and liquid, for example in order to measure the local activity from ion channels in the cell membrane....... The electrical resistance of carbon nanotubes has been shown to be extremely sensitive to gas molecules. Dielectrophoresis is a method capable of quickly attracting nanotubes on microelectrodes by using an electric field, thus enabling nanotube integration in microsystems. Dielectrophoresis offers also....... A model for the dielectrophoretic assembly of carbon nanotubes on microelectrodes was developed and several simulations were conducted using values from the available literature for the various key parameters. The model can give qualitative results regarding the parameters dominating the dielectrophoretic...

  19. Dielectrophoretic assay of bacterial resistance to antibiotics

    International Nuclear Information System (INIS)

    Johari, Juliana; Huebner, Yvonne; Hull, Judith C; Dale, Jeremy W; Hughes, Michael P

    2003-01-01

    The dielectrophoretic collection spectra of antibiotic-sensitive and antibiotic-resistant strains of Staphylococcus epidermidis have been determined. These indicate that in the absence of antibiotic treatment there is a strong similarity between the dielectric properties of sensitive and resistant strains, and that there is a significant difference between the sensitive strains before and after treatment with the antibiotic streptomycin after 24 h exposure. This method offers possibilities for the assessment of bacterial resistance to antibiotics. (note)

  20. Experimental tests on ratchet of structural elements diagrams for primary tension and secondary twist

    International Nuclear Information System (INIS)

    Lebey, J.; Roche, R.L.; Cousseran, P.

    1980-05-01

    Design by analysis of pressure vessels is not complete without an appraisal of failure by progressive distortion or stress ratchet. Ratchet tests under constant axial stress associated with cyclic torsion deformation have been carried out on 304 L and 316 L thin tubular specimens, at room temperature. Results are given in the form of iso-deformation curves ranging from 0.1% to 2.5%, in the field definite by the primary and secondary stress intensities (Bree's diagram type). The use of an effective primary stress is proposed, as a practical way, to assess the elongation due to the ratchet effect

  1. Dielectrophoretic Microfluidic Device for in Vitro Fertilization

    Directory of Open Access Journals (Sweden)

    Hong-Yuan Huang

    2018-03-01

    Full Text Available The aim of this work was to create a microfluidic platform that uses in vitro fertilization (IVF and avoids unnecessary damage to oocytes due to the dielectrophoretic force manipulation of the sperms and oocytes that occurs in a traditional IVF operation. The device from this research can serve also to decrease medium volumes, as well as the cost of cell culture under evaporation, and to prevent unnecessary risk in intracytoplasmic sperm injection (ICSI. To decrease the impact and destruction of the oocyte and the sperm, we adopted a positive dielectrophoretic force to manipulate both the sperms and the oocyte. The mouse oocytes were trapped with a positive dielectrophoretic (p-DEP force by using Indium Tin Oxide (ITO-glass electrodes; the ITO-glass electrode chip was fabricated by wet etching the ITO-glass. The polydimethylsiloxane (PDMS flow-focusing microfluidic device was used to generate microdroplets of micrometer size to contain the zygotes. The volume of the microdroplets was controlled by adjusting the flow rates of both inlets for oil and the DEP buffer. As a result, the rate of fertilization was increased by about 5% beyond that of the DEP treatment in traditional IVF, and more than 20% developed to the blastocyst stage with a low sperm-oocyte ratio.

  2. Shakedown and ratchetting below the creep range

    International Nuclear Information System (INIS)

    Ponter, A.R.S.

    1983-01-01

    The report reviews current understanding of the behaviour of structure subject to variable mechanical and thermal loading below the creep range through a comparison of theoretical solutions and experimental studies. The particular characteristics of the austenitic stainless steels are emphasized in components subject to moderate primary loads and large thermal loads. The review shows that a clear classification of types of thermal loading is required in design. Two main classes, termed category A and B, exist which arise not from the magnitude of the thermal stresses but their extent through the material volume of the structure. In category A situations, the Bree plate problem being the prime example, the maximum thermal stresses occur over a volume of the structure which does not contain a mechanism of failure. As a result very large thermal stresses may be withstood without ratchetting occurring for sufficiently small mechanical loads. For category B situations, the maximum thermal stress occur within a volume of material which contains a mechanism of deformation. In such cases, the capacity of the structure to withstand thermal loading is limited by a variation of the maximum thermal stress at a material point of 2σsub(γ) where σsub(γ) is a suitably defined yield stress. This situation seems to be the most typical problem of the Liquid Metal Fast Reactor and the ''3Sm'' limit in the ASME III code restriction on secondary stress cannot be exceeded if ratchetting is to be prevented

  3. Harmonic ratcheting for fast acceleration

    Science.gov (United States)

    Cook, N.; Brennan, J. M.; Peggs, S.

    2014-04-01

    A major challenge in the design of rf cavities for the acceleration of medium-energy charged ions is the need to rapidly sweep the radio frequency over a large range. From low-power medical synchrotrons to high-power accelerator driven subcritical reactor systems, and from fixed focus alternating gradient accelerators to rapid cycling synchrotrons, there is a strong need for more efficient, and faster, acceleration of protons and light ions in the semirelativistic range of hundreds of MeV/u. A conventional way to achieve a large, rapid frequency sweep (perhaps over a range of a factor of 6) is to use custom-designed ferrite-loaded cavities. Ferrite rings enable the precise tuning of the resonant frequency of a cavity, through the control of the incremental permeability that is possible by introducing a pseudoconstant azimuthal magnetic field. However, rapid changes over large permeability ranges incur anomalous behavior such as the "Q-loss" and "f-dot" loss phenomena that limit performance while requiring high bias currents. Notwithstanding the incomplete understanding of these phenomena, they can be ameliorated by introducing a "harmonic ratcheting" acceleration scheme in which two or more rf cavities take turns accelerating the beam—one turns on when the other turns off, at different harmonics—so that the radio frequency can be constrained to remain in a smaller range. Harmonic ratcheting also has straightforward performance advantages, depending on the particular parameter set at hand. In some typical cases it is possible to halve the length of the cavities, or to double the effective gap voltage, or to double the repetition rate. This paper discusses and quantifies the advantages of harmonic ratcheting in general. Simulation results for the particular case of a rapid cycling medical synchrotron ratcheting from harmonic number 9 to 2 show that stability and performance criteria are met even when realistic engineering details are taken into consideration.

  4. Thermal ratcheting and creep damage

    International Nuclear Information System (INIS)

    Clement, G.; Cousseran, P.; Roche, R.L.

    1983-01-01

    Several proposals have been made to assist adesigners with thermal ratcheting in the creep range, the more known has been made by O'DONNELL and POROWSKY. Unfortunately these methods are not validated by experiments, and they take only inelastic distortion into consideration as creep effects. The aim of the work presented here is to correct these deficiencies - in providing an experimental basis to ratcheting analysis rules in the creep range, - in considering the effect of cyclic straining (like cyclic thermal stresses) on the time to rupture by creep. Experimental tests have been performed on austenitic stainless steel at 650 0 C for the first item. Results of these tests and results available in the open literature have been used to built a practical rule of ratcheting analysis. This rule giving a conservative value of the creep distortion, is based on the concept of effective primary stress which is an amplification of the primary stress really applied. Concerning the second point (time to rupture), it was necessary to obtain real creep rupture and not instability. According to the proposal of Pr LECKIE, tests were performed on specimens made out of copper, and of aluminium alloys at temperatures between 150 0 C and 300 0 C. With such materials creep rupture is obtained without necking. Experimental tests show that cyclic straining reduces the time to creep rupture under load controlled stress. Caution must be given to the designer: cyclic thermal stress can lead to premature creep rupture. (orig./GL)

  5. Cell Patterning for Liver Tissue Engineering via Dielectrophoretic Mechanisms

    Directory of Open Access Journals (Sweden)

    Wan Nurlina Wan Yahya

    2014-07-01

    Full Text Available Liver transplantation is the most common treatment for patients with end-stage liver failure. However, liver transplantation is greatly limited by a shortage of donors. Liver tissue engineering may offer an alternative by providing an implantable engineered liver. Currently, diverse types of engineering approaches for in vitro liver cell culture are available, including scaffold-based methods, microfluidic platforms, and micropatterning techniques. Active cell patterning via dielectrophoretic (DEP force showed some advantages over other methods, including high speed, ease of handling, high precision and being label-free. This article summarizes liver function and regenerative mechanisms for better understanding in developing engineered liver. We then review recent advances in liver tissue engineering techniques and focus on DEP-based cell patterning, including microelectrode design and patterning configuration.

  6. Thermal ratcheting and creep damage

    International Nuclear Information System (INIS)

    Clement, G.; Cousseran, P.; Roche, R.L.

    1983-08-01

    Creep is a cause of deformation; it may also result in rupture in time. Although LMFBR structures are not heavily loaded, they are subjected to large thermal transients. Can structure lifetime be shortened by such transients. Several proposals have been made to assist adesigners with thermal ratcheting in the creep range. Unfortunately these methods are not validated by experiments, and they take only inelastic distorsion into consideration as creep effects. The aim of the work presented here is to correct these deficiencies in providing an experimental basis to ratcheting analysis rules in the creep range, and in considering the effect of cyclic straining (like cyclic thermal stresses) on the time to rupture by creep. Experimental tests have been performed on austenitic stainless steel at 650 0 C for the first item. Results of these tests and results available in the open literature have been used to built a practical rule of ratcheting analysis. This rule giving a conservative value of the creep distortion, is based on the concept of effective primary stress which is an amplification of the primary stress really applied. Concerning the second point (time to rupture), it was necessary to obtain real creep rupture and not instability. According to the proposal of Pr LECKIE, tests were performed on specimen made out of copper, and of aluminium alloys at temperatures between 150 0 C and 300 0 C. With such materials creep rupture is obtained without necking. Experimental tests show that cyclic straining reduces the time to creep rupture under load controlled stress. Caution must be given to the designer: cyclic thermal stress can lead to premature creep rupture

  7. Ratcheting of pressurized piping subjected to seismic loading

    International Nuclear Information System (INIS)

    Scavuzzo, R.J.; Lam, P.C.; Gau, J.S.

    1992-01-01

    The ABAQUS finite element code was used to model a pressurized pipe and subjected to cyclic bending loads to investigate ratcheting. A 1-in. schedule 40 pipe was loaded with a slow (static) cyclic load. The pipe internal pressure was varied from 0 to 6000 psi. In this paper, two types of materials were considered: an elastic perfectly plastic and a bilinear elastic-plastic material. Two types of finite elements of the ABAQUS program were compared to analytical solutions to evaluate the element accuracy in the plastic regime. Depending upon loading conditions and specified material properties, three different responses were observed from the finite element analyses: cyclic plasticity, ratcheting of the hoop strain, or shakedown. These analytical results are compared to some experimental measurements

  8. Ratcheting up the ratchet: on the evolution of cumulative culture.

    Science.gov (United States)

    Tennie, Claudio; Call, Josep; Tomasello, Michael

    2009-08-27

    Some researchers have claimed that chimpanzee and human culture rest on homologous cognitive and learning mechanisms. While clearly there are some homologous mechanisms, we argue here that there are some different mechanisms at work as well. Chimpanzee cultural traditions represent behavioural biases of different populations, all within the species' existing cognitive repertoire (what we call the 'zone of latent solutions') that are generated by founder effects, individual learning and mostly product-oriented (rather than process-oriented) copying. Human culture, in contrast, has the distinctive characteristic that it accumulates modifications over time (what we call the 'ratchet effect'). This difference results from the facts that (i) human social learning is more oriented towards process than product and (ii) unique forms of human cooperation lead to active teaching, social motivations for conformity and normative sanctions against non-conformity. Together, these unique processes of social learning and cooperation lead to humans' unique form of cumulative cultural evolution.

  9. Ratcheting up the ratchet: on the evolution of cumulative culture

    Science.gov (United States)

    Tennie, Claudio; Call, Josep; Tomasello, Michael

    2009-01-01

    Some researchers have claimed that chimpanzee and human culture rest on homologous cognitive and learning mechanisms. While clearly there are some homologous mechanisms, we argue here that there are some different mechanisms at work as well. Chimpanzee cultural traditions represent behavioural biases of different populations, all within the species’ existing cognitive repertoire (what we call the ‘zone of latent solutions’) that are generated by founder effects, individual learning and mostly product-oriented (rather than process-oriented) copying. Human culture, in contrast, has the distinctive characteristic that it accumulates modifications over time (what we call the ‘ratchet effect’). This difference results from the facts that (i) human social learning is more oriented towards process than product and (ii) unique forms of human cooperation lead to active teaching, social motivations for conformity and normative sanctions against non-conformity. Together, these unique processes of social learning and cooperation lead to humans’ unique form of cumulative cultural evolution. PMID:19620111

  10. Seismic ratchet-fatigue failure of piping systems

    International Nuclear Information System (INIS)

    Severud, L.K.; Anderson, M.J.; Lindquist, M.R.; Weiner, E.O.

    1987-01-01

    Failures of piping systems during earthquakes have been rare. Those that have failed were either made of brittle material such as cast iron, were rigid systems between major components where component relative seismic motions tore the pipe out of the component, or were high pressure systems where a ratchet-fatigue fracture followed a local bulging of the pipe diameter. Tests to failure of an unpressurized 3-inch and a pressurized 6-inch diameter carbon steel nuclear pipe systems subjected to high-level shaking have been accomplished. The high-level shaking loads needed to cause failure were much higher than ASME Code rules would permit with present design limits. Failure analyses of these tests are presented and correlated to the test results. It was found that failure of the unpressurized system could be correlated well with standard ASME type fatigue analysis predictions. Moreover, the pressurized system failure occured in significantly less load cycles than predicted by standard fatigue analysis. However, a ratchet-fatigue and ductility exhaustion analysis of the pressurized system did correlate reasonably well. These findings indicate modifications to design analysis methods and the present ASME Code piping design rules to reduce unneeded conservatisms and to cover the ratchet-fatigue failure mode may be appropriate

  11. Seismic ratchet-fatigue failure of piping systems

    International Nuclear Information System (INIS)

    Severud, L.K.; Anderson, M.J.; Lindquist, M.R.; Weiner, E.O.

    1986-01-01

    Failures of piping systems during earthquakes have been rare. Those that have failed were either made of brittle material such as cast iron, were rigid systems between major components where component relative seismic motions tore the pipe out of the component, or were high pressure systems where a ratchet-fatigue fracture followed a local bulging of the pipe diameter. Tests to failure of an unpressurized 3-in. and a pressurized 6-in. diameter carbon steel nuclear pipe systems subjected to high level shaking have been accomplished. Failure analyses of these tests are presented and correlated to the test results. It was found that failure of the unpressurized system could be correlated well with standard ASME type fatigue analysis predictions. Moreover, the pressurized system failure occurred in significantly less load cycles than predicted by standard fatigue analysis. However, a ratchet-fatigue and ductility exhaustion analysis of the pressurized system did correlate very well. These findings indicate modifications to design analysis methods and the present ASME Code piping design rules may be appropriate to cover the ratchet-fatigue failure mode

  12. Investigations on the ratchetting behaviour of austenitic pipes

    International Nuclear Information System (INIS)

    Kraemer, D.; Krolop, S.; Scheffold, A.; Stegmeyer, R.

    1994-01-01

    Reversed bending tests at room temperature with pipes with and without internal pressure were carried out. The pipes were manufactured from the austenitic steel X10 CrNiNb 18 9. Under internal pressure ratchetting was observed in circumferential direction. The component tests were accompanied by numerical computations using a nonlinear kinematic hardening rule and superposed isotropic hardening. In total the constitutive model needed 13 parameters to be fitted when isotropic hardening resulted in a cyclic saturation. Uniaxial monotonic and cyclic loading tests served for characterizing the material. A reasonable parameter fitting with respect to describe ratchetting required load controlled nonzero mean-stress tests. On condition, that the loading will lead to cyclic saturation, ratchetting could be well predicted in the pipe with the found set of parameters. An extension of the isotropic hardening rule in the constitutive model was proposed allowing to describe various types of isotropic hardening. In a first step it was shown that under uniaxial conditions the extension reproduces continuous isotropic hardening up to incipient cracking quite well. (orig.)

  13. Thermal ratcheting and progressive buckling

    International Nuclear Information System (INIS)

    Lebey, J.; Brouard, D.; Roche, R.L.

    1983-01-01

    Pure elastic buckling is not a frequent mode of failure and plastic deformations often occurs before buckling - like instability does. Elastic-plastic buckling is very difficult to analyse. The most important difficulty is the material modeling. In the elastic plastic buckling phenomena, small modifications of the material constitutive equation used are of great influence on the final result. When buckling cannot occurs, it is well known that distortion due to applied loads is greatly amplified when there is also some cyclic straining (like thermal stresses). This effect is called ratcheting - and thermal ratcheting when caused by cyclic thermal transients. As cyclic thermal stresses can be applied in addition of load able to cause buckling failure of a component, the question arise of the effect of cyclic thermal stresses on the critical buckling load. The aim of the work presented here is to answer that question: 'Is the critical buckling load reduced when cyclic straining is added'. It seems sensible to avoid premature computation based only on arbitrary assumptions and to prefer obtaining a sound experimental basis for analysis. Sufficient experimental knowledge is needed in order to check the validity of the material modeling (and imperfections) used in analysis. Experimental tests on buckling of compressed columns subjected to cyclic straining have been performed. These experiments are described and results are given. The most important result is cyclic straining reduces the critical buckling load. It appears that distortion can be increasing progressively during cyclic straining and that buckling can happen at last at compressive loads too small to cause buckling in the absence of cyclic straining. (orig./RW)

  14. Dielectrophoretic focusing integrated pulsed laser activated cell sorting

    Science.gov (United States)

    Zhu, Xiongfeng; Kung, Yu-Chun; Wu, Ting-Hsiang; Teitell, Michael A.; Chiou, Pei-Yu

    2017-08-01

    We present a pulsed laser activated cell sorter (PLACS) integrated with novel sheathless size-independent dielectrophoretic (DEP) focusing. Microfluidic fluorescence activated cell sorting (μFACS) systems aim to provide a fully enclosed environment for sterile cell sorting and integration with upstream and downstream microfluidic modules. Among them, PLACS has shown a great potential in achieving comparable performance to commercial aerosol-based FACS (>90% purity at 25,000 cells sec-1). However conventional sheath flow focusing method suffers a severe sample dilution issue. Here we demonstrate a novel dielectrophoresis-integrated pulsed laser activated cell sorter (DEP-PLACS). It consists of a microfluidic channel with 3D electrodes laid out to provide a tunnel-shaped electric field profile along a 4cmlong channel for sheathlessly focusing microparticles/cells into a single stream in high-speed microfluidic flows. All focused particles pass through the fluorescence detection zone along the same streamline regardless of their sizes and types. Upon detection of target fluorescent particles, a nanosecond laser pulse is triggered and focused in a neighboring channel to generate a rapidly expanding cavitation bubble for precise sorting. DEP-PLACS has achieved a sorting purity of 91% for polystyrene beads at a throughput of 1,500 particle/sec.

  15. Experimental quantum ratchets based on nanostructures

    International Nuclear Information System (INIS)

    Linke, H.; Loefgren, A.; Sheng, W.; Xu, H.; Svensson, A.; Omling, P.; Lindelof, P.E.

    1999-01-01

    Full text: A number of biological processes, for instance muscular contraction and intracellular transport, are based on a fascinating physical principle: In periodic, asymmetric potentials, so-called ratchets, the random motion of Brownian particles can be put to use by extracting energy from nonequilibrium fluctuations. These findings have recently revived interest in physics to explore the general principles of ratchet effects. So far, most ratchet systems studied assumed or used classical systems. In extension of this previous work, highly interesting and new physics can also be expected from ratchet mechanisms that rely on quantum processes. In this contribution, the requirements for experimental studies of quantum ratchet effects will be discussed, and it will be pointed out that these prerequisites are ideally fulfilled in semiconductor- and metal-nanostructures. As an example, experimental and theoretical results will be presented showing that phase-coherent, asymmetric (triangular) electron cavities can partially rectify an applied AC voltage. Using this effect, which is related to electron wave interference, an electron current can be generated without applied net field

  16. Molecular wires acting as quantum heat ratchets.

    Science.gov (United States)

    Zhan, Fei; Li, Nianbei; Kohler, Sigmund; Hänggi, Peter

    2009-12-01

    We explore heat transfer in molecular junctions between two leads in the absence of a finite net thermal bias. The application of an unbiased time-periodic temperature modulation of the leads entails a dynamical breaking of reflection symmetry, such that a directed heat current may emerge (ratchet effect). In particular, we consider two cases of adiabatically slow driving, namely, (i) periodic temperature modulation of only one lead and (ii) temperature modulation of both leads with an ac driving that contains a second harmonic, thus, generating harmonic mixing. Both scenarios yield sizable directed heat currents, which should be detectable with present techniques. Adding a static thermal bias allows one to compute the heat current-thermal load characteristics, which includes the ratchet effect of negative thermal bias with positive-valued heat flow against the thermal bias, up to the thermal stop load. The ratchet heat flow in turn generates also an electric current. An applied electric stop voltage, yielding effective zero electric current flow, then mimics a solely heat-ratchet-induced thermopower ("ratchet Seebeck effect"), although no net thermal bias is acting. Moreover, we find that the relative phase between the two harmonics in scenario (ii) enables steering the net heat current into a direction of choice.

  17. Dielectrophoresis and dielectrophoretic impedance detection of adenovirus and rotavirus

    Science.gov (United States)

    Nakano, Michihiko; Ding, Zhenhao; Suehiro, Junya

    2016-01-01

    The aim of this study is the electrical detection of pathogenic viruses, namely, adenovirus and rotavirus, using dielectrophoretic impedance measurement (DEPIM). DEPIM consists of two simultaneous processes: dielectrophoretic trapping of the target and measurement of the impedance change and increase in conductance with the number of trapped targets. This is the first study of applying DEPIM, which was originally developed to detect bacteria suspended in aqueous solutions, to virus detection. The dielectric properties of the viruses were also investigated in terms of their dielectrophoretic behavior. Although their estimated dielectric properties were different from those of bacteria, the trapped viruses increased the conductance of the microelectrode in a manner similar to that in bacteria detection. We demonstrated the electrical detection of viruses within 60 s at concentrations as low as 70 ng/ml for adenovirus and 50 ng/ml for rotavirus.

  18. Impedance technique for measuring dielectrophoretic collection of microbiological particles

    CERN Document Server

    Allsopp, D W E; Brown, A P; Betts, W B

    1999-01-01

    Measurement of the impedance change resulting from the collection of microbiological particles at coplanar electrodes is shown to be an effective and potentially quantitative method of detecting dielectrophoresis. Strong correlations between the frequency-dependent dielectrophoretic collection characteristics measured by impedance change and those observed using an established counting method based on image analysis have been obtained for Escherichia coli. In addition it is shown that the new electrical method can be used to sense dielectrophoretic collection of 19 nm diameter latex beads, particles too small to be resolved by conventional optical detection systems. (author)

  19. Ratchet device with broken friction symmetry

    DEFF Research Database (Denmark)

    Norden, Bengt; Zolotaryuk, Yaroslav; Christiansen, Peter Leth

    2002-01-01

    An experimental setup (gadget) has been made for demonstration of a ratchet mechanism induced by broken symmetry of a dependence of dry friction on external forcing. This gadget converts longitudinal oscillating or fluctuating motion into a unidirectional rotation, the direction of which is in ac......An experimental setup (gadget) has been made for demonstration of a ratchet mechanism induced by broken symmetry of a dependence of dry friction on external forcing. This gadget converts longitudinal oscillating or fluctuating motion into a unidirectional rotation, the direction of which...... is in accordance with given theoretical arguments. Despite the setup being three dimensional, the ratchet rotary motion is proved to be described by one simple dynamic equation. This kind of motion is a result of the interplay of friction and inertia....

  20. Granular Segregation by an Oscillating Ratchet Mechanism

    International Nuclear Information System (INIS)

    Igarashi, A.; Horiuchi, Ch.

    2004-01-01

    We report on a method to segregate granular mixtures which consist of two kinds of particles by an oscillating ''ratchet'' mechanism. The segregation system has an asymmetrical sawtooth-shaped base which is vertically oscillating. Such a ratchet base produces a directional current of particles owing to its transport property. It is a counterintuitive and interesting phenomenon that a vertically vibrated base transports particles horizontally. This system is studied with numerical simulations, and it is found that we can apply such a system to segregation of mixtures of particles with different properties (radius or mass). Furthermore, we find out that an appropriate inclination of the ratchet-base makes the quality of segregation high. (author)

  1. Reversible Vector Ratchet Effect in Skyrmion Systems

    Science.gov (United States)

    Ma, Xiaoyu; Reichhardt, Charles; Reichhardt, Cynthia

    Magnetic skyrmions are topological non-trivial spin textures found in several magnetic materials. Since their motion can be controlled using ultralow current densities, skyrmions are appealing for potential applications in spintronics as information carriers and processing devices. In this work, we studied the collective transport properties of driven skyrmions based on a particle-like model with molecular dynamics (MD) simulation. Our results show that ac driven skyrmions interacting with an asymmetric substrate provide a realization of a new class of ratchet system, which we call a vector ratchet, that arises due to the effect of the Magnus term on the skyrmion dynamics. In a vector ratchet, the dc motion induced by the ac drive can be described as a vector that can be rotated up to 360 degrees relative to the substrate asymmetry direction. This could represent a new method for controlling skyrmion motion for spintronic applications.

  2. Modelization of ratcheting in biaxial experiments

    International Nuclear Information System (INIS)

    Guionnet, C.

    1989-08-01

    A new unified viscoplastic constitutive equation has been developed in order to interpret ratcheting experiments on mechanical structures of fast reactors. The model is based essentially on a generalized Armstrong Frederick equation for the kinematic variable; the coefficients of the dynamic recovery term in this equation is a function of both instantaneous and accumulated inelastic strain which is allowed to vary in an appropriate manner in order to reproduce the experimental ratcheting rate. The validity of the model is verified by comparing predictions with experimental results for austenitic stainless steel (17-12 SPH) tubular specimens subjected to cyclic torsional loading under constant tensile stress at 600 0 C [fr

  3. Uniaxial ratcheting behavior of Zircaloy-4 tubes at room temperature

    International Nuclear Information System (INIS)

    Wen, Mingjian; Li, Hua; Yu, Dunji; Chen, Gang; Chen, Xu

    2013-01-01

    In this study, a series of uniaxial tensile, strain cycling and uniaxial ratcheting tests were conducted at room temperature on Zircaloy-4 (Zr-4) tubes used as nuclear fuel cladding in Pressurized Water Reactors (PWRs) for the purpose to investigate the uniaxial ratcheting behavior of Zr-4 and the factors which may influence it. The experimental results show that at room temperature this material features cyclic softening remarkably within the strain range of 1.6%, and former cycling under larger strain amplitude cannot retard cyclic softening of later cycling under lower strain amplitude. Uniaxial ratcheting strain accumulates in the direction of mean stress, and the ratcheting stain level is larger under tensile mean stress than that under compressive mean stress. Uniaxial ratcheting strain level increases with the increase of mean stress and stress amplitude, and decreases with the increase of loading rate. The sequence of loading rate appears to have no effects on the final ratcheting strain accumulation. Loading history has great influence on the uniaxial ratcheting behavior. Lower stress level after loading history with higher stress level leads to the shakedown of ratcheting. Higher loading rate after loading history with lower loading rate brings down the ratcheting strain rate. Uniaxial ratcheting behavior is sensitive to compressive pre-strain, and the decay rate of the ratcheting strain rate is slowed down by pre-compression

  4. Ratchetting in the creep range

    International Nuclear Information System (INIS)

    Ponter, A.R.S.; Cocks, A.C.F.; Clement, G.; Roche, R.; Corradi, L.; Franchi, A.

    1985-01-01

    This report attempts to present a ''State of the Art'' of this problem from three contracting and complementary points of view which reflect separate traditions within the discipline of structural analysis. Part I gives a brief summary of the essential elements of the three constitutive parts and a set of conclusions and recommendations are then formulated. Part II is an attempt by a group at CEA Saclay, France, to distil from available experimental data a set of rules expressed in terms of the stress classifications of the ASME codes, which will ensure the prevention of excessive creep ratchetting. The resulting stresses to an effective (or reference) stress and the creep assessment is then made in terms of the creep produced by the effective stress. They aim at analytical procedures for LMFBR components that operate in the creep region and are subject to considerable thermal transients. Part III by Ponter and Cocks of the University of Leicester is a theoretical study of the problem using bounding and other approximate techniques. The problem is studied in a sequence of increasingly complex problems commencing with an isothermal structure subjected to constant load and terminating in a structure subjected to arbitrary cyclic thermal loading. The results are expressed in terms of a reference stress derived from a plastic shakedown solution, and a reference history of temperature. These techniques are capable of providing assessment of the creep deformation of a structure when the plastic shakedown properties of the structures are known. The particular circumstances which occur in a LMFBR are emphasized. Part IV by Corradi and Franchi discusses the methods by which finite element solution may be calculated. These are surveyed with particular reference to the numerical problems involved and the relationship between computational procedure and the form of the constitutive equation. 162 refs

  5. Experimental quantum ratchets based on solid state nanostructures

    International Nuclear Information System (INIS)

    Linke, H.

    1999-01-01

    Ratchets are spatially asymmetric devices in which particles can move on average in one direction in the absence of external net forces or gradients. This is made possible by the rectification of fluctuations, which also provide the energy for the process. Interest in the physics of ratchets was revived in recent years when it emerged that the ratchet principle may be a suitable physical model for 'molecular motors', which are central to many fundamental biological processes, such as intracellular transport or muscle contraction. Most ratchets studied so far have relied on classical effects, but recently 'quantum ratchets', involving quantum effects, have also been studied. In the present article it is pointed out that semiconductor or metal nanostructures are very suitable systems for the realisation of experimental quantum ratchets. Recent experimental studies of a quantum ratchet based on an asymmetric quantum dot are reviewed. Copyright (1999) CSIRO Australia

  6. Viability of dielectrophoretically trapped neuronal cortical cells in culture

    NARCIS (Netherlands)

    Heida, Tjitske; Vulto, P; Rutten, Wim; Marani, Enrico

    2001-01-01

    Negative dielectrophoretic trapping of neural cells is an efficient way to position neural cells on the electrode sites of planar micro-electrode arrays. The preservation of viability of the neural cells is essential for this approach. This study investigates the viability of postnatal cortical rat

  7. A design rule about thermal ratcheting

    International Nuclear Information System (INIS)

    Clement, G.; Lebey, J.; Roche, R.L.

    1984-01-01

    The purpose of this paper is to present an analysis of thermal ratcheting, and to give a practical design rule aimed at avoiding its detrimental effects. A practical method will thus be available to designers for dealing with one of the adverse effects of computed thermal stresses

  8. Engineering Autonomous Chemomechanical Nanomachines Using Brownian Ratchets

    Science.gov (United States)

    Lavella, Gabriel

    Nanoscale machines which directly convert chemical energy into mechanical work are ubiquitous in nature and are employed to perform a diverse set of tasks such as transporting molecules, maintaining molecular gradients, and providing motion to organisms. Their widespread use in nature suggests that large technological rewards can be obtained by designing synthetic machines that use similar mechanisms. This thesis addresses the technological adaptation of a specific mechanism known as the Brownian ratchet for the design of synthetic autonomous nanomachines. My efforts were focused more specifically on synthetic chemomechanical ratchets which I deem will be broadly applicable in the life sciences. In my work I have theoretically explored the biophysical mechanisms and energy landscapes that give rise to the ratcheting phenomena and devised devices that operate off these principles. I demonstrate two generations of devices that produce mechanical force/deformation in response to a user specified ligand. The first generation devices, fabricatied using a combination nanoscale lithographic processes and bioconjugation techniques, were used to provide evidence that the proposed ratcheting phenomena can be exploited in synthetic architectures. Second generation devices fabricated using self-assembled DNA/hapten motifs were constructed to gain a precise understanding of ratcheting dynamics and design constraints. In addition, the self-assembled devices enabled fabrication en masse, which I feel will alleviate future experimental hurdles in analysis and facilitate its adaptation to technologies. The product of these efforts is an architecture that has the potential to enable numerous technologies in biosensing and drug delivery. For example, the coupling of molecule-specific actuation to the release of drugs or signaling molecules from nanocapsules or porous materials could be transformative. Such architectures could provide possible avenues to pressing issues in biology and

  9. Direct current dielectrophoretic manipulation of the ionic liquid droplets in water.

    Science.gov (United States)

    Zhao, Kai; Li, Dongqing

    2018-07-13

    The ionic liquids (ILs) as the environmentally benign solvents show great potentials in microemulsion carrier systems and have been widely used in the biochemical and pharmaceutical fields. In the work, the ionic liquid-in-water microemulsions were fabricated by using two kinds of hydrophobic ionic liquid, 1-Butyl-3-methylimidazolium hexafluorophosphate [Bmim][PF 6 ] and 1-Hexyl-3-methylimidazolium hexafluorophosphate [Hmim][PF 6 ] with Tween 20. The ionic liquid droplets in water experience the dielectrophoretic (DEP) forces induced by applying electrical field via a nano-orifice and a micron orifice on the opposite channel walls of a microchannel. The dielectrophoretic behaviors of the ionic liquid-in-water emulsion droplets were investigated under direct current (DC) electric field. The positive and negative DEP behaviors of the ionic liquid-in-water droplets varying with the electrical conductivity of the suspending medium were investigated and two kinds of the ionic liquid droplets of similar sizes were separated by their different DEP behaviors. In addition, the separation of the ionic liquid-in-water droplets by size was conducted. This paper, for the first time to our knowledge, presents the DC-DEP manipulation of the ionic liquid-in-water emulsion droplets by size and by type. This method provides a platform to manipulate the ionic liquid droplets individually. Copyright © 2018 Elsevier B.V. All rights reserved.

  10. Punchets: nonlinear transport in Hamiltonian pump-ratchet hybrids

    Science.gov (United States)

    Dittrich, Thomas; Medina Sánchez, Nicolás

    2018-02-01

    ‘Punchets’ are hybrids between ratchets and pumps, combining a spatially periodic static potential, typically asymmetric under space inversion, with a local driving that breaks time-reversal invariance, and are intended to model metal or semiconductor surfaces irradiated by a collimated laser beam. Their crucial feature is irregular driven scattering between asymptotic regions supporting periodic (as opposed to free) motion. With all binary spatio-temporal symmetries broken, scattering in punchets typically generates directed currents. We here study the underlying nonlinear transport mechanisms, from chaotic scattering to the parameter dependence of the currents, in three types of Hamiltonian models, (i) with spatially periodic potentials where only in the driven scattering region, spatial and temporal symmetries are broken, and (ii), spatially asymmetric (ratchet) potentials with a driving that only breaks time-reversal invariance. As more realistic models of laser-irradiated surfaces, we consider (iii), a driving in the form of a running wave confined to a compact region by a static envelope. In this case, the induced current can even run against the direction of wave propagation, drastically evidencing its nonlinear nature. Quantizing punchets is indicated as a viable research perspective.

  11. Analysis and application of ratcheting evaluation procedure of Japanese high temperature design code DDS

    International Nuclear Information System (INIS)

    Lee, H. Y.; Kim, J. B.; Lee, J. H.

    2002-01-01

    In this study, the evaluation procedure of Japanese DDS code which was recently developed to assess the progressive inelastic deformation occurring under repetition of secondary stresses was analyzed and the evaluation results according to DDS was compared those of the thermal ratchet structural test carried out by KAERI to analyze the conservativeness of the code. The existing high temperature codes of US ASME-NH and French RCC-MR suggest the limited ratcheting procedures for only the load cases of cyclic secondary stresses under primary stresses. So they are improper to apply to the actual ratcheting problem which can occur under cyclic secondary membrane stresses due to the movement of hot free surface for the pool type LMR. DDS provides explicitly an analysis procedure of ratcheting due to moving thermal gradients near hot free surface. A comparison study was carried out between the results by the design code of DDS and by the structural test to investigate the conservativeness of DDS code, which showed that the evaluation results by DDS were in good agreement with those of the structural test

  12. Molecular wires acting as quantum heat ratchets

    OpenAIRE

    Zhan, Fei; Li, Nianbei; Kohler, Sigmund; Hänggi, Peter

    2009-01-01

    We explore heat transfer in molecular junctions between two leads in the absence of a finite net thermal bias. The application of an unbiased, time-periodic temperature modulation of the leads entails a dynamical breaking of reflection symmetry, such that a directed heat current may emerge (ratchet effect). In particular, we consider two cases of adiabatically slow driving, namely (i) periodic temperature modulation of only one lead and (ii) temperature modulation of both leads with an ac dri...

  13. Dielectrophoretic capture of low abundance cell population using thick electrodes

    OpenAIRE

    Marchalot, Julien; Chateaux, Jean-François; Faivre, Magalie; Mertani, Hichem C.; Ferrigno, Rosaria; Deman, Anne-Laure

    2015-01-01

    Enrichment of rare cell populations such as Circulating Tumor Cells (CTCs) is a critical step before performing analysis. This paper presents a polymeric microfluidic device with integrated thick Carbon-PolyDimethylSiloxane composite (C-PDMS) electrodes designed to carry out dielectrophoretic (DEP) trapping of low abundance biological cells. Such conductive composite material presents advantages over metallic structures. Indeed, as it combines properties of both the matrix and doping particle...

  14. ASME code and ratcheting in piping components. Final technical report

    International Nuclear Information System (INIS)

    Hassan, T.; Matzen, V.C.

    1999-01-01

    The main objective of this research is to develop an analysis program which can accurately simulate ratcheting in piping components subjected to seismic or other cyclic loads. Ratcheting is defined as the accumulation of deformation in structures and materials with cycles. This phenomenon has been demonstrated to cause failure to piping components (known as ratcheting-fatigue failure) and is yet to be understood clearly. The design and analysis methods in the ASME Boiler and Pressure Vessel Code for ratcheting of piping components are not well accepted by the practicing engineering community. This research project attempts to understand the ratcheting-fatigue failure mechanisms and improve analysis methods for ratcheting predictions. In the first step a state-of-the-art testing facility is developed for quasi-static cyclic and seismic testing of straight and elbow piping components. A systematic testing program to study ratcheting is developed. Some tests have already been performed and the rest will be completed by summer'99. Significant progress has been made in the area of constitutive modeling. A number of sophisticated constitutive models have been evaluated in terms of their simulations for a broad class of ratcheting responses. From the knowledge gained from this evaluation study two improved models are developed. These models are demonstrated to have promise in simulating ratcheting responses in piping components. Hence, implementation of these improved models in widely used finite element programs, ANSYS and/or ABAQUS, is in progress. Upon achieving improved finite element programs for simulation of ratcheting, the ASME Code provisions for ratcheting of piping components will be reviewed and more rational methods will be suggested. Also, simplified analysis methods will be developed for operability studies of piping components and systems. Some of the future works will be performed under the auspices of the Center for Nuclear Power Plant Structures

  15. A Ratchet Lens: Black Queer Youth, Agency, Hip Hop, and the Black Ratchet Imagination

    Science.gov (United States)

    Love, Bettina L.

    2017-01-01

    This article explores the utilization of the theory of a Black ratchet imagination as a methodological perspective to examine the multiple intersections of Black and queer identity constructions within the space of hip hop. In particular, I argue for the need of a methodological lens that recognizes, appreciates, and struggles with the fluidity,…

  16. High temperature viscoplastic ratchetting: Material response or modeling artifact

    International Nuclear Information System (INIS)

    Freed, A.D.

    1991-01-01

    Ratchetting, the net accumulation of strain over a loading cycle, is a deformation mechanism that leads to distortions in shape, often resulting in a loss of function that culminates in structural failure. Viscoplastic ratchetting is prevalent at high homologous temperatures where viscous characteristics are prominent in material response. This deformation mechanism is accentuated by the presence of a mean stress; a consequence of interaction between thermal gradients and structural constraints. Favorable conditions for viscoplastic ratchetting exist in the Stirling engines being developed by the National Aeronautics and Space Administration (NASA) and the Department of Energy (DOE) for space and terrestrial power applications. To assess the potential for ratchetting and its effect on durability of high temperature structures requires a viscoplastic analysis of the design. But ratchetting is a very difficult phenomenon to accurately model. One must therefore ask whether the results from such an analysis are indicative of actual material behavior, or if they are artifacts of the theory being used in the analysis. There are several subtle aspects in a viscoplastic model that must be dealt with in order to accurately model ratchetting behavior, and therefore obtain meaningful predictions from it. In this paper, some of these subtlties and the necessary ratchet experiments needed to obtain an accurate viscoplastic representation of a material are discussed

  17. Dielectrophoretic Manipulation and Separation of Microparticles Using Microarray Dot Electrodes

    Directory of Open Access Journals (Sweden)

    Bashar Yafouz

    2014-04-01

    Full Text Available This paper introduces a dielectrophoretic system for the manipulation and separation of microparticles. The system is composed of five layers and utilizes microarray dot electrodes. We validated our system by conducting size-dependent manipulation and separation experiments on 1, 5 and 15 μm polystyrene particles. Our findings confirm the capability of the proposed device to rapidly and efficiently manipulate and separate microparticles of various dimensions, utilizing positive and negative dielectrophoresis (DEP effects. Larger size particles were repelled and concentrated in the center of the dot by negative DEP, while the smaller sizes were attracted and collected by the edge of the dot by positive DEP.

  18. Polymer cantilever platform for dielectrophoretic assembly of carbon nanotubes

    DEFF Research Database (Denmark)

    Johansson, Alicia; Calleja, M.; Dimaki, Maria

    2004-01-01

    A polymer cantilever platform for dielectrophoretic assembly of carbon nanotubes has been designed and realized. Multi-walled carbon nanotubes from aqueous solution have been assembled between two metal electrodes that are separated by 2 mu m and embedded in the polymer cantilever. The entire chip......, except for the metallic electrodes and wiring, was fabricated in the photoresist SU-8. SU-8 allows for an inexpensive, flexible and fast fabrication method, and the cantilever platform provides a hydrophobic surface that should be well suited for nanotube assembly. The device can be integrated in a micro...

  19. Thermal stress ratcheting analysis of a time-hardening structure

    International Nuclear Information System (INIS)

    Hada, Kazuhiko

    1999-01-01

    Thermal stress ratcheting and shakedown is analyzed for a time-hardening structure: the yield stress increases as time goes on under exposure to neutron irradiation or thermal aging. New three modes of ratcheting and shakedown are identified as transition to other deformation modes. Stress regimes and thermal ratchet strains are formulated as a function of time-increasing yield stress. Moreover, a new model of trouble occurrence frequency as a modification to a bath-tube curve is proposed for calculating a time period of a thermal cycle. Application of the proposed formulation tells us a benefit of taking into account the time hardening due to neutron irradiation. (author)

  20. Monte Carlo simulations of interacting particle mixtures in ratchet potentials

    International Nuclear Information System (INIS)

    Fendrik, A J; Romanelli, L

    2012-01-01

    There are different models of devices for achieving a separation of mixtures of particles by using the ratchet effect. On the other hand, it has been proposed that one could also control the separation by means of appropriate interactions. Through Monte Carlo simulations, we show that inclusion of simple interactions leads to a decrease of the ratchet effect and therefore also a separation of the mixtures.

  1. Polymer deformation in Brownian ratchets: theory and molecular dynamics simulations.

    Science.gov (United States)

    Kenward, Martin; Slater, Gary W

    2008-11-01

    We examine polymers in the presence of an applied asymmetric sawtooth (ratchet) potential which is periodically switched on and off, using molecular dynamics (MD) simulations with an explicit Lennard-Jones solvent. We show that the distribution of the center of mass for a polymer in a ratchet is relatively wide for potential well depths U0 on the order of several kBT. The application of the ratchet potential also deforms the polymer chains. With increasing U0 the Flory exponent varies from that for a free three-dimensional (3D) chain, nu=35 (U0=0), to that corresponding to a 2D compressed (pancake-shaped) polymer with a value of nu=34 for moderate U0. This has the added effect of decreasing a polymer's diffusion coefficient from its 3D value D3D to that of a pancaked-shaped polymer moving parallel to its minor axis D2D. The result is that a polymer then has a time-dependent diffusion coefficient D(t) during the ratchet off time. We further show that this suggests a different method to operate a ratchet, where the off time of the ratchet, toff, is defined in terms of the relaxation time of the polymer, tauR. We also derive a modified version of the Bader ratchet model [Bader, Proc. Natl. Acad. Sci. U.S.A. 96, 13165 (1999)] which accounts for this deformation and we present a simple expression to describe the time dependent diffusion coefficient D(t). Using this model we then illustrate that polymer deformation can be used to modulate polymer migration in a ratchet potential.

  2. Ratchet effect on a relativistic particle driven by external forces

    International Nuclear Information System (INIS)

    Quintero, Niurka R; Alvarez-Nodarse, Renato; Cuesta, Jose A

    2011-01-01

    We study the ratchet effect of a damped relativistic particle driven by both asymmetric temporal bi-harmonic and time-periodic piecewise constant forces. This system can be formally solved for any external force, providing the ratchet velocity as a nonlinear functional of the driving force. This allows us to explicitly illustrate the functional Taylor expansion formalism recently proposed for this kind of systems. The Taylor expansion reveals particularly useful to obtain the shape of the current when the force is periodic, piecewise constant. We also illustrate the somewhat counterintuitive effect that introducing damping may induce a ratchet effect. When the force is symmetric under time-reversal and the system is undamped, under symmetry principles no ratchet effect is possible. In this situation increasing damping generates a ratchet current which, upon increasing the damping coefficient eventually reaches a maximum and decreases toward zero. We argue that this effect is not specific of this example and should appear in any ratchet system with tunable damping driven by a time-reversible external force. (paper)

  3. Ratchet effect on a relativistic particle driven by external forces

    Energy Technology Data Exchange (ETDEWEB)

    Quintero, Niurka R [Departamento de Fisica Aplicada I, Escuela Universitaria Politecnica, Universidad de Sevilla, Calle Virgen de Africa 7, E-41011 Sevilla (Spain); Alvarez-Nodarse, Renato [Departamento de Analisis Matematico, Facultad de Matematicas, Universidad de Sevilla, Apdo 1160, E-41080 Sevilla (Spain); Cuesta, Jose A, E-mail: niurka@us.es, E-mail: ran@us.es, E-mail: cuesta@math.uc3m.es [Grupo Interdisciplinar de Sistemas Complejos (GISC), Departamento de Matematicas, Universidad Carlos III de Madrid, Avenida de la Universidad 30, E-28911 Leganes, Madrid (Spain)

    2011-10-21

    We study the ratchet effect of a damped relativistic particle driven by both asymmetric temporal bi-harmonic and time-periodic piecewise constant forces. This system can be formally solved for any external force, providing the ratchet velocity as a nonlinear functional of the driving force. This allows us to explicitly illustrate the functional Taylor expansion formalism recently proposed for this kind of systems. The Taylor expansion reveals particularly useful to obtain the shape of the current when the force is periodic, piecewise constant. We also illustrate the somewhat counterintuitive effect that introducing damping may induce a ratchet effect. When the force is symmetric under time-reversal and the system is undamped, under symmetry principles no ratchet effect is possible. In this situation increasing damping generates a ratchet current which, upon increasing the damping coefficient eventually reaches a maximum and decreases toward zero. We argue that this effect is not specific of this example and should appear in any ratchet system with tunable damping driven by a time-reversible external force. (paper)

  4. A 3-D Microelectrode System for Dielectrophoretic Manipulation of Microparticles

    International Nuclear Information System (INIS)

    Chen, D F; Du, H; Gong, H Q; Li, W H

    2006-01-01

    This paper presents a microfluidic system for manipulation and separation of micron-sized particles based on the combined use of negative dielectrophoresis (DEP) and hydrodynamic forces. A 3-D microelectrode structure (so called paired electrode array) are constructed face to face on the top and bottom sides of the microchannel and driven with highfrequency AC voltage to generate dielectrophoretic gates. Depending on the relative strengths of the two forces, particles such as polystyrene beads or cells carrying by a laminar flow can either penetrate the gate or settle there. This gives rise to certain applications including selectively concentrating particles from the flow, separating particles depending on their sizes or dielectric properties, and automatically positioning particles to selective locations. For this purpose, a microfluidic device consisting of the paired electrode array sitting on the channel has been fabricated using microfabrication techniques. Polystyrene beads were used to study the performance of the device. Experimental results including the concentration and separation of particles are presented

  5. Dielectrophoretic capture of low abundance cell population using thick electrodes.

    Science.gov (United States)

    Marchalot, Julien; Chateaux, Jean-François; Faivre, Magalie; Mertani, Hichem C; Ferrigno, Rosaria; Deman, Anne-Laure

    2015-09-01

    Enrichment of rare cell populations such as Circulating Tumor Cells (CTCs) is a critical step before performing analysis. This paper presents a polymeric microfluidic device with integrated thick Carbon-PolyDimethylSiloxane composite (C-PDMS) electrodes designed to carry out dielectrophoretic (DEP) trapping of low abundance biological cells. Such conductive composite material presents advantages over metallic structures. Indeed, as it combines properties of both the matrix and doping particles, C-PDMS allows the easy and fast integration of conductive microstructures using a soft-lithography approach while preserving O2 plasma bonding properties of PDMS substrate and avoiding a cumbersome alignment procedure. Here, we first performed numerical simulations to demonstrate the advantage of such thick C-PDMS electrodes over a coplanar electrode configuration. It is well established that dielectrophoretic force ([Formula: see text]) decreases quickly as the distance from the electrode surface increases resulting in coplanar configuration to a low trapping efficiency at high flow rate. Here, we showed quantitatively that by using electrodes as thick as a microchannel height, it is possible to extend the DEP force influence in the whole volume of the channel compared to coplanar electrode configuration and maintaining high trapping efficiency while increasing the throughput. This model was then used to numerically optimize a thick C-PDMS electrode configuration in terms of trapping efficiency. Then, optimized microfluidic configurations were fabricated and tested at various flow rates for the trapping of MDA-MB-231 breast cancer cell line. We reached trapping efficiencies of 97% at 20 μl/h and 78.7% at 80 μl/h, for 100 μm thick electrodes. Finally, we applied our device to the separation and localized trapping of CTCs (MDA-MB-231) from a red blood cells sample (concentration ratio of 1:10).

  6. Multiaxial ratcheting behavior of zirconium alloy tubes under combined cyclic axial load and internal pressure

    Energy Technology Data Exchange (ETDEWEB)

    Chen, G.; Zhang, X. [School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072 (China); Xu, D.K. [Environmental Corrosion Center, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016 (China); Li, D.H. [Hunan Taohuajiang Nuclear Power Co., Ltd, Yiyang, 413000 (China); Chen, X. [School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072 (China); Zhang, Z., E-mail: zhe.zhang@tju.edu.cn [School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072 (China)

    2017-06-15

    In this study, a series of uniaxial and multiaxial ratcheting tests were conducted at room temperature on zirconium alloy tubes. The experimental results showed that for uniaxial symmetrical cyclic test, the axial ratcheting strain ɛ{sub x} did not accumulate obviously in initial stage, but gradually increased up to 1% with increasing stress amplitude σ{sub xa}. For multiaxial ratcheting tests, the zirconium alloy tube was highly sensitive to both the axial stress amplitude σ{sub xa} and the internal pressure p{sub i}. The hoop ratcheting strain ɛ{sub θ} increased continuously with the increase of axial stress amplitude, whereas the evolution of axial ratcheting strain ɛ{sub x} was related to the axial stress amplitude. The internal pressure restricted the ratcheting accumulation in the axial direction, but promoted the hoop ratcheting strain on the contrary. The prior loading history greatly restrained the ratcheting behavior of subsequent cycling with a small internal pressure. - Highlights: •Uniaxial and multiaxial ratcheting behavior of the zirconium alloy tubes are investigated at room temperature. •The ratcheting depends greatly on the stress amplitude or internal pressure. •The interaction between the axial and hoop ratcheting mechanisms is greatly dependent on the internal pressure level. •The ratcheting is influenced significantly by the loading history of internal pressure.

  7. Dislocation based controlling of kinematic hardening contribution to simulate primary and secondary stages of uniaxial ratcheting

    Science.gov (United States)

    Bhattacharjee, S.; Dhar, S.; Acharyya, S. K.

    2017-07-01

    The primary and secondary stages of the uniaxial ratcheting curve for the C-Mn steel SA333 have been investigated. Stress controlled uniaxial ratcheting experiments were conducted with different mean stresses and stress amplitudes to obtain curves showing the evolution of ratcheting strain with number of cycles. In stage-I of the ratcheting curve, a large accumulation of ratcheting strain occurs, but at a decreasing rate. In contrast, in stage-II a smaller accumulation of ratcheting strain is found and the ratcheting rate becomes almost constant. Transmission electron microscope observations reveal that no specific dislocation structures are developed during the early stages of ratcheting. Rather, compared with the case of low cycle fatigue, it is observed that sub-cell formation is delayed in the case of ratcheting. The increase in dislocation density as a result of the ratcheting strain is obtained using the Orowan equation. The ratcheting strain is obtained from the shift of the plastic strain memory surface. The dislocation rearrangement is incorporated in a functional form of dislocation density, which is used to calibrate the parameters of a kinematic hardening law. The observations are formulated in a material model, plugged into the ABAQUS finite element (FE) platform as a user material subroutine. Finally the FE-simulated ratcheting curves are compared with the experimental curves.

  8. Multiaxial ratcheting behavior of zirconium alloy tubes under combined cyclic axial load and internal pressure

    International Nuclear Information System (INIS)

    Chen, G.; Zhang, X.; Xu, D.K.; Li, D.H.; Chen, X.; Zhang, Z.

    2017-01-01

    In this study, a series of uniaxial and multiaxial ratcheting tests were conducted at room temperature on zirconium alloy tubes. The experimental results showed that for uniaxial symmetrical cyclic test, the axial ratcheting strain ɛ x did not accumulate obviously in initial stage, but gradually increased up to 1% with increasing stress amplitude σ xa . For multiaxial ratcheting tests, the zirconium alloy tube was highly sensitive to both the axial stress amplitude σ xa and the internal pressure p i . The hoop ratcheting strain ɛ θ increased continuously with the increase of axial stress amplitude, whereas the evolution of axial ratcheting strain ɛ x was related to the axial stress amplitude. The internal pressure restricted the ratcheting accumulation in the axial direction, but promoted the hoop ratcheting strain on the contrary. The prior loading history greatly restrained the ratcheting behavior of subsequent cycling with a small internal pressure. - Highlights: •Uniaxial and multiaxial ratcheting behavior of the zirconium alloy tubes are investigated at room temperature. •The ratcheting depends greatly on the stress amplitude or internal pressure. •The interaction between the axial and hoop ratcheting mechanisms is greatly dependent on the internal pressure level. •The ratcheting is influenced significantly by the loading history of internal pressure.

  9. Ratcheting fatigue behavior of Zircaloy-2 at room temperature

    Energy Technology Data Exchange (ETDEWEB)

    Rajpurohit, R.S., E-mail: rsrajpurohit.rs.met13@iitbhu.ac.in [Department of Metallurgical Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi, 221005 (India); Sudhakar Rao, G. [Nuclear Energy and Safety Department, Paul Scherrer Institute, Villigen, CH-5232 (Switzerland); Chattopadhyay, K.; Santhi Srinivas, N.C.; Singh, Vakil [Department of Metallurgical Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi, 221005 (India)

    2016-08-15

    Nuclear core components of zirconium alloys experience asymmetric stress or strain cycling during service which leads to plastic strain accumulation and drastic reduction in fatigue life as well as dimensional instability of the component. Variables like loading rate, mean stress, and stress amplitude affect the influence of asymmetric loading. In the present investigation asymmetric stress controlled fatigue tests were conducted with mean stress from 80 to 150 MPa, stress amplitude from 270 to 340 MPa and stress rate from 30 to 750 MPa/s to study the process of plastic strain accumulation and its effect on fatigue life of Zircaloy-2 at room temperature. It was observed that with increase in mean stress and stress amplitude accumulation of ratcheting strain was increased and fatigue life was reduced. However, increase in stress rate led to improvement in fatigue life due to less accumulation of ratcheting strain. - Highlights: • Ratcheting strain accumulation occurred due to asymmetric cyclic loading. • Accumulation of ratcheting strain increased with mean stress and stress amplitude. • Ratcheting strain accumulation decreased with increase in stress rate. • With increase in mean stress and stress amplitude there was reduction in fatigue life. • Fatigue life is improved with increase in stress rate.

  10. Investigations into the ratchetting behaviour of austenitic pipes

    International Nuclear Information System (INIS)

    Kraemer, D.; Krolop, S.; Scheffold, A.; Stegmeyer, R.

    1997-01-01

    In technical components subjected to cyclic loading, inelastic deformations cannot be excluded. In such cases, under certain conditions, small amounts of non-reversed plastic strain per cycle can accumulate to large strains, an effect commonly called ratchetting. The proof of ratchetting in complex structures is often possible by numerical methods only, e.g. the finite-element method. Describing cyclic plasticity and predicting ratchetting necessitate a suitable constitutive law. This paper describes the investigation of the ratchetting behaviour of thin-walled tubes under cyclic loading. Tests were performed and accompanied by finite-element computations using a non-linear kinematic hardening rule with superposed isotropic cyclic hardening. The constitutive law applied used a set of 13 material parameters. This paper discusses the requirements for uniaxial tests which meet the determination of a suitable set of parameters for describing ratchetting. To describe different kinds of isotropic hardening, an extension of the isotropic hardening rule is proposed. Under uniaxial conditions, continuous cyclic hardening is well reproduced with this extension. (orig.)

  11. Simplified design rule for ratcheting analysis

    International Nuclear Information System (INIS)

    Cousseran, P.; Clement, G.; Lebey, J.; Roche, R.L.

    1982-07-01

    Ratcheting in the creep range is the magnification of primary stress effects caused by cyclic straining. Computation results do not agree with experimental results due to the complexity of the real material behavior. From the results of experimental tests a design rule based on the concept of effective primary stress Psub(eff) is proposed. The effective primary stress is a fictitious primary stress giving the same effect that the real loading i.e. the same effect that the combination of an applied primary stress P and a cyclic straining quoted by the range Qsub(R) of secondary stress variation. Determination of an upper bound value of Psub(eff) is made with the help of an efficiency diagram. More precisely the efficiency diagram include a curve giving a conservative value of an efficiency index V = P/Psub(eff) as a function of the secondarity quotient SQ = Qsub(R)/P. Finally limitation of Psub(eff) intensity is discussed in regard with the current practice

  12. Rare beneficial mutations can halt Muller's ratchet

    Science.gov (United States)

    Balick, Daniel; Goyal, Sidhartha; Jerison, Elizabeth; Neher, Richard; Shraiman, Boris; Desai, Michael

    2012-02-01

    In viral, bacterial, and other asexual populations, the vast majority of non-neutral mutations are deleterious. This motivates the application of models without beneficial mutations. Here we show that the presence of surprisingly few compensatory mutations halts fitness decay in these models. Production of deleterious mutations is balanced by purifying selection, stabilizing the fitness distribution. However, stochastic vanishing of fitness classes can lead to slow fitness decay (i.e. Muller's ratchet). For weakly deleterious mutations, production overwhelms purification, rapidly decreasing population fitness. We show that when beneficial mutations are introduced, a stable steady state emerges in the form of a dynamic mutation-selection balance. We argue this state is generic for all mutation rates and population sizes, and is reached as an end state as genomes become saturated by either beneficial or deleterious mutations. Assuming all mutations have the same magnitude selective effect, we calculate the fraction of beneficial mutations necessary to maintain the dynamic balance. This may explain the unexpected maintenance of asexual genomes, as in mitochondria, in the presence of selection. This will affect in the statistics of genetic diversity in these populations.

  13. Flashing subdiffusive ratchets in viscoelastic media

    International Nuclear Information System (INIS)

    Kharchenko, Vasyl; Goychuk, Igor

    2012-01-01

    We study subdiffusive ratchet transport in periodically and randomly flashing potentials. A central Brownian particle is elastically coupled to the surrounding auxiliary Brownian quasi-particles, which account for the influence of the viscoelastic environment. Similar to standard dynamical modeling of Brownian motion, the external force influences only the motion of the central particle, not affecting directly the environmental degrees of freedom. Just a handful of auxiliary Brownian particles suffices to model subdiffusion over many temporal decades. Time modulation of the potential violates the symmetry of thermal detailed balance and induces an anomalous subdiffusive current which exhibits a remarkably small dispersion at low temperatures, as well as a number of other surprising features such as saturation at low temperatures, and multiple inversions of the transport direction upon a change of the driving frequency in the non-adiabatic regime. It is shown that the subdiffusive current is finite at zero temperature for random flashing and can be finite for periodic flashing for a certain frequency window. Our study generalizes classical Brownian motors towards operating in sticky viscoelastic environments such as the cytosol of biological cells or dense polymer solutions. (paper)

  14. Experimental analysis of ratchetting in elbows

    International Nuclear Information System (INIS)

    Acker, D.; Touboul, F.; Brouard, D.

    1991-01-01

    Despite of their apparent simplicity, elbows or curved tubes are one of the most tested and analyzed structures to the last years when a large effort has been done by CEA in the framework of the European Structural Integrity Working Group in order to reassess the RCC-MR (1985) piping design rules for elbows and straight parts (TOUBOUL (1988-1989)). It is impossible to mention all the authors and an extensive bibliography has been done by BENDJEDIDIA (1987). But nobody in our knowledge has taken care in experimental validation of design rules against ratcheting. With such objectives, an experimental test program has been performed at CEA, in order to appraise the design methods based on shakedown model like 3 S m rule used by ASME section III (1989) in USA or RCC-M (1988) in FRANCE, or based on the efficiency Diagram used by the french design code for Fast Breeder reactors RCC-MR (1985). The first results were published by M. BENDJEDIDIA (1987). They have been completed by additional tests and improved by a better material characterisation

  15. Nanoscale magnetic ratchets based on shape anisotropy

    Science.gov (United States)

    Cui, Jizhai; Keller, Scott M.; Liang, Cheng-Yen; Carman, Gregory P.; Lynch, Christopher S.

    2017-02-01

    Controlling magnetization using piezoelectric strain through the magnetoelectric effect offers several orders of magnitude reduction in energy consumption for spintronic applications. However strain is a uniaxial effect and, unlike directional magnetic field or spin-polarized current, cannot induce a full 180° reorientation of the magnetization vector when acting alone. We have engineered novel ‘peanut’ and ‘cat-eye’ shaped nanomagnets on piezoelectric substrates that undergo repeated deterministic 180° magnetization rotations in response to individual electric-field-induced strain pulses by breaking the uniaxial symmetry using shape anisotropy. This behavior can be likened to a magnetic ratchet, advancing magnetization clockwise with each piezostrain trigger. The results were validated using micromagnetics implemented in a multiphysics finite elements code to simulate the engineered spatial and temporal magnetic behavior. The engineering principles start from a target device function and proceed to the identification of shapes that produce the desired function. This approach opens a broad design space for next generation magnetoelectric spintronic devices.

  16. Quantum ratchets for quantum communication with optical superlattices

    International Nuclear Information System (INIS)

    Romero-Isart, Oriol; Garcia-Ripoll, Juan Jose

    2007-01-01

    We propose to use a quantum ratchet to transport quantum information in a chain of atoms trapped in an optical superlattice. The quantum ratchet is created by a continuous modulation of the optical superlattice which is periodic in time and in space. Though there is zero average force acting on the atoms, we show that indeed the ratchet effect permits atoms on even and odd sites to move along opposite directions. By loading the optical lattice with two-level bosonic atoms, this scheme permits us to perfectly transport a qubit or entangled state imprinted in one or more atoms to any desired position in the lattice. From the quantum computation point of view, the transport is achieved by a smooth concatenation of perfect swap gates. We analyze setups with noninteracting and interacting particles and in the latter case we use the tools of optimal control to design optimal modulations. We also discuss the feasibility of this method in current experiments

  17. A new approach for primary overloads allowance in ratcheting evaluation

    International Nuclear Information System (INIS)

    Cabrillat, M.T.; Gatt, J.M.; Lejeail, Y.

    1995-01-01

    Seismic loading must be taken into account in ratchetting design analysis. In LMFBR structures it mainly produces primary overloads, which are characterised by severe magnitudes but a generally low number of occurrences. Other cases of several primary overloads can also observed in pipes during emptying operations for instance. In the RCC-MR design code rule, the maximum primary stress supported by a structure is considered as permanent. No allowance is made for temporary load. Experimental ratchetting tests conducted on different structures with and without overloads clearly point out that temporary overloads lead to less ratchetting effect. A method using the RCC-MR efficiency diagram framework is proposed. A general theoretical approach allows to extend its field of application of various cases of primary loading: constant or null primary loading or overloads. Experimental results are then used to check the validity of this new approach. (author). 2 refs., 2 figs., 2 tabs

  18. Near-Field, On-Chip Optical Brownian Ratchets.

    Science.gov (United States)

    Wu, Shao-Hua; Huang, Ningfeng; Jaquay, Eric; Povinelli, Michelle L

    2016-08-10

    Nanoparticles in aqueous solution are subject to collisions with solvent molecules, resulting in random, Brownian motion. By breaking the spatiotemporal symmetry of the system, the motion can be rectified. In nature, Brownian ratchets leverage thermal fluctuations to provide directional motion of proteins and enzymes. In man-made systems, Brownian ratchets have been used for nanoparticle sorting and manipulation. Implementations based on optical traps provide a high degree of tunability along with precise spatiotemporal control. Here, we demonstrate an optical Brownian ratchet based on the near-field traps of an asymmetrically patterned photonic crystal. The system yields over 25 times greater trap stiffness than conventional optical tweezers. Our technique opens up new possibilities for particle manipulation in a microfluidic, lab-on-chip environment.

  19. Thermal ratchetting in pipes subjected to intermittent thermal downshocks at elevated temperatures

    International Nuclear Information System (INIS)

    Corum, J.M.; Young, H.C.; Grindell, A.G.

    1974-01-01

    The results of two thermal ratchetting tests on straight sections of pipe are presented. The pipes, each of which was machined from a well-characterized heat of type 304 stainless steel, were subjected to a series of thermal downshocks on their inner surface, followed by sustained periods under an internal pressure loading at a temperature of 1100 0 F. Testing was carried out in a special sodium test facility built for the purpose, and the outer surface strain histories were measured using high-temperature capacitive strain gages. The circumferential strain responses, which typify the inelastic behaviors, are presented. 7 references. (U.S.)

  20. Segregation of granular binary mixtures by a ratchet mechanism.

    Science.gov (United States)

    Farkas, Zénó; Szalai, Ferenc; Wolf, Dietrich E; Vicsek, Tamás

    2002-02-01

    We report on a segregation scheme for granular binary mixtures, where the segregation is performed by a ratchet mechanism realized by a vertically shaken asymmetric sawtooth-shaped base in a quasi-two-dimensional box. We have studied this system by computer simulations and found that most binary mixtures can be segregated using an appropriately chosen ratchet, even when the particles in the two components have the same size and differ only in their normal restitution coefficient or friction coefficient. These results suggest that the components of otherwise nonsegregating granular mixtures may be separated using our method.

  1. Thermo-mechanical ratcheting in jointed rock masses

    KAUST Repository

    Pasten, C.; Garcí a, M.; Santamarina, Carlos

    2015-01-01

    Thermo-mechanical coupling takes place in jointed rock masses subjected to large thermal oscillations. Examples range from exposed surfaces under daily and seasonal thermal fluctuations to subsurface rock masses affected by engineered systems such as geothermal operations. Experimental, numerical and analytical results show that thermo-mechanical coupling can lead to wedging and ratcheting mechanisms that result in deformation accumulation when the rock mass is subjected to a biased static-force condition. Analytical and numerical models help in identifying the parameter domain where thermo-mechanical ratcheting can take place.

  2. Transverse ratchet effect and superconducting vortices: simulation and experiment

    International Nuclear Information System (INIS)

    Dinis, L; Parrondo, J M R; Perez de Lara, D; Gonzalez, E M; Vicent, J L; Anguita, J V

    2009-01-01

    A transverse ratchet effect has been measured in magnetic/superconducting hybrid films fabricated by electron beam lithography and magnetron sputtering techniques. The samples are Nb films grown on top of an array of Ni nanotriangles. Injecting an ac current parallel to the triangle reflection symmetry axis yields an output dc voltage perpendicular to the current, due to a net motion of flux vortices in the superconductor. The effect is reproduced by numerical simulations of vortices as Langevin particles with realistic parameters. Simulations provide an intuitive picture of the ratchet mechanism, revealing the fundamental role played by the random intrinsic pinning of the superconductor.

  3. Thermo-mechanical ratcheting in jointed rock masses

    KAUST Repository

    Pasten, C.

    2015-09-01

    Thermo-mechanical coupling takes place in jointed rock masses subjected to large thermal oscillations. Examples range from exposed surfaces under daily and seasonal thermal fluctuations to subsurface rock masses affected by engineered systems such as geothermal operations. Experimental, numerical and analytical results show that thermo-mechanical coupling can lead to wedging and ratcheting mechanisms that result in deformation accumulation when the rock mass is subjected to a biased static-force condition. Analytical and numerical models help in identifying the parameter domain where thermo-mechanical ratcheting can take place.

  4. Ratcheting problems for ITER [International Thermonuclear Experimental Reactor

    International Nuclear Information System (INIS)

    Majumdar, S.

    1991-01-01

    Because of the presence of high cyclic thermal stress, pressure-induced primary stress, and disruption-induced high cyclic primary stress, ratcheting of the first wall poses a serious challenge to the designers of ITER (International Thermonuclear Experimental Reactor). Existing design tools such as the Bree diagram in the ASME Boiler and Pressure Vessels Code, are not directly applicable to ITER, because of important differences in geometry and loading modes. Available alternative models for ratcheting are discussed and new Bree diagrams, that are more relevant for fusion reactor applications, are proposed. 9 refs., 17 figs

  5. Dielectrophoretic sample preparation for environmental monitoring of microorganisms: Soil particle removal.

    Science.gov (United States)

    Fatoyinbo, Henry O; McDonnell, Martin C; Hughes, Michael P

    2014-07-01

    Detection of pathogens from environmental samples is often hampered by sensors interacting with environmental particles such as soot, pollen, or environmental dust such as soil or clay. These particles may be of similar size to the target bacterium, preventing removal by filtration, but may non-specifically bind to sensor surfaces, fouling them and causing artefactual results. In this paper, we report the selective manipulation of soil particles using an AC electrokinetic microfluidic system. Four heterogeneous soil samples (smectic clay, kaolinitic clay, peaty loam, and sandy loam) were characterised using dielectrophoresis to identify the electrical difference to a target organism. A flow-cell device was then constructed to evaluate dielectrophoretic separation of bacteria and clay in a continous flow through mode. The average separation efficiency of the system across all soil types was found to be 68.7% with a maximal separation efficiency for kaolinitic clay at 87.6%. This represents the first attempt to separate soil particles from bacteria using dielectrophoresis and indicate that the technique shows significant promise; with appropriate system optimisation, we believe that this preliminary study represents an opportunity to develop a simple yet highly effective sample processing system.

  6. Modeling of uniaxial ratchetting behavior of SA333 carbon manganese steel

    International Nuclear Information System (INIS)

    Shit, J.; Dhar, S.; Acharyya, S.K.; Goyal, S.

    2012-01-01

    The paper deals with uniaxial ratcheting phenomenon of cyclic plasticity behavior of the materials SA333 carbon Manganese steel. A mechanistic model for the ratcheting phenomenon has been proposed. It is observed that von Mises yield criterion together with Chaboche’s kinematic hardening rules are not sufficient to model ratcheting phenomenon. Other associated phenomena like plastic strain memory surface, back stress memory points and over all the extra hardening behavior have to be incorporated to get a complete material model for ratcheting. The proposed model assembled all these ideas together with von Mises yield criterion and Chabache’s kinematic hardening rule. Low cycle fatigue tests and uniaxial ratcheting tests have been conducted for the materials. The material constants are identified and derived from experimental results. The ratcheting coefficients have been properly calibrated with these material constants. The material model, as mentioned above, for the ratcheting phenomenon has been implemented in an elastic plastic finite element code. The ratcheting results for different stress controlled ratcheting loads have been computed. The good feature of this model is that it reduces to symmetric low cycle fatigue model when loop closes. - Highlights: ► A common material model to simulate symmetric LCF and ratcheting. ► Extra hardening to take care the shift of plastic strain centre. ► Material parameters from tensile and LCF tests. ► Saturated loop in LCF and ratcheting strain rate is compared with experiment. ► Consideration of loading path, memory path and their directions.

  7. Continuous particle separation in a serpentine microchannel via negative and positive dielectrophoretic focusing

    International Nuclear Information System (INIS)

    Church, Christopher; Zhu, Junjie; Nieto, Juan; Keten, Gyunay; Ibarra, Erl; Xuan, Xiangchun

    2010-01-01

    Dielectrophoresis (DEP) has been widely used to focus and separate cells and particles in microfluidic devices. This work first demonstrates negative and positive dielectrophoretic focusing of particles in a serpentine microchannel by changing only the electric conductivity of the suspending fluid. Due to the channel turn-induced dielectrophoretic force, particles are focused to either the centerline or the sidewalls of the channel when their electric conductivity is lower (i.e. negative DEP) or higher (i.e. positive DEP) than that of the fluid. These distinctive dielectrophoretic focusing phenomena in a serpentine microchannel are then combined to implement a continuous separation between particles of different sizes and electric conductivities. Such separation eliminates the fabrication of in-channel microelectrodes or micro-insulators that are typically required in DEP-based separation techniques. A numerical model is also developed to predict the particle motion, and the simulation results agree reasonably with the observed particle focusing and separation behaviors.

  8. Simulation study of dielectrophoretic assembly of nanowire between electrode pairs

    Energy Technology Data Exchange (ETDEWEB)

    Tao, Quan, E-mail: taq3@pitt.edu; Lan, Fei; Jiang, Minlin [University of Pittsburgh, The Department of Electrical and Computer Engineering (United States); Wei, Fanan [Chinese Academy of Sciences, State Key Laboratory of Robotics, Shenyang Institute of Automation (China); Li, Guangyong, E-mail: gul6@pitt.edu [University of Pittsburgh, The Department of Electrical and Computer Engineering (United States)

    2015-07-15

    Dielectrophoresis (DEP) of rod-shaped nanostructures is attractive because of its exceptional capability to fabricate nanowire-based electronic devices. This efficient manipulation method, however, has a common side effect of assembling a certain number of nanowires at undesired positions. It is therefore essential to understand the underlying physics of DEP of nanowires in order to better guide the assembly. In this work, we propose theoretical methods to characterize the dielectrophoretic force and torque as well as the hydrodynamic drag force and torque on the nanowire (typical length: 10 μm). The trajectory of the nanowire is then simulated based on rigid body dynamics. The nanowire is predicted to either bridge the electrodes or attach on the surface of one electrode. A neighborhood in which the nanowire is more likely to bridge electrodes is found, which is conducive to successful assembly. The simulation study in this work provides us not only a better understanding of the underlying physics but also practical guidance on nanowire assembly by DEP.

  9. Nanotip analysis for dielectrophoretic concentration of nanosized viral particles.

    Science.gov (United States)

    Yeo, Woon-Hong; Lee, Hyun-Boo; Kim, Jong-Hoon; Lee, Kyong-Hoon; Chung, Jae-Hyun

    2013-05-10

    Rapid and sensitive detection of low-abundance viral particles is strongly demanded in health care, environmental control, military defense, and homeland security. Current detection methods, however, lack either assay speed or sensitivity, mainly due to the nanosized viral particles. In this paper, we compare a dendritic, multi-terminal nanotip ('dendritic nanotip') with a single terminal nanotip ('single nanotip') for dielectrophoretic (DEP) concentration of viral particles. The numerical computation studies the concentration efficiency of viral particles ranging from 25 to 100 nm in radius for both nanotips. With DEP and Brownian motion considered, when the particle radius decreases by two times, the concentration time for both nanotips increases by 4-5 times. In the computational study, a dendritic nanotip shows about 1.5 times faster concentration than a single nanotip for the viral particles because the dendritic structure increases the DEP-effective area to overcome the Brownian motion. For the qualitative support of the numerical results, the comparison experiment of a dendritic nanotip and a single nanotip is conducted. Under 1 min of concentration time, a dendritic nanotip shows a higher sensitivity than a single nanotip. When the concentration time is 5 min, the sensitivity of a dendritic nanotip for T7 phage is 10(4) particles ml(-1). The dendritic nanotip-based concentrator has the potential for rapid identification of viral particles.

  10. Nanotip analysis for dielectrophoretic concentration of nanosized viral particles

    International Nuclear Information System (INIS)

    Yeo, Woon-Hong; Lee, Hyun-Boo; Kim, Jong-Hoon; Chung, Jae-Hyun; Lee, Kyong-Hoon

    2013-01-01

    Rapid and sensitive detection of low-abundance viral particles is strongly demanded in health care, environmental control, military defense, and homeland security. Current detection methods, however, lack either assay speed or sensitivity, mainly due to the nanosized viral particles. In this paper, we compare a dendritic, multi-terminal nanotip (‘dendritic nanotip’) with a single terminal nanotip (‘single nanotip’) for dielectrophoretic (DEP) concentration of viral particles. The numerical computation studies the concentration efficiency of viral particles ranging from 25 to 100 nm in radius for both nanotips. With DEP and Brownian motion considered, when the particle radius decreases by two times, the concentration time for both nanotips increases by 4–5 times. In the computational study, a dendritic nanotip shows about 1.5 times faster concentration than a single nanotip for the viral particles because the dendritic structure increases the DEP-effective area to overcome the Brownian motion. For the qualitative support of the numerical results, the comparison experiment of a dendritic nanotip and a single nanotip is conducted. Under 1 min of concentration time, a dendritic nanotip shows a higher sensitivity than a single nanotip. When the concentration time is 5 min, the sensitivity of a dendritic nanotip for T7 phage is 10 4 particles ml −1 . The dendritic nanotip-based concentrator has the potential for rapid identification of viral particles. (paper)

  11. Motional dispersions and ratchet effect in inertial systems

    Indian Academy of Sciences (India)

    without the application of any time-averaged external field is termed as ratchet effect [1]. This is necessarily a ... The effect can also be obtained if the system is driven periodically but time asymmetrically in such a way that the ..... Govt. of India for financial assistance (SR/FTP/PS-33/2004). References. [1] P Reimann, Phys.

  12. Active Brownian motion models and applications to ratchets

    Science.gov (United States)

    Fiasconaro, A.; Ebeling, W.; Gudowska-Nowak, E.

    2008-10-01

    We give an overview over recent studies on the model of Active Brownian Motion (ABM) coupled to reservoirs providing free energy which may be converted into kinetic energy of motion. First, we present an introduction to a general concept of active Brownian particles which are capable to take up energy from the source and transform part of it in order to perform various activities. In the second part of our presentation we consider applications of ABM to ratchet systems with different forms of differentiable potentials. Both analytical and numerical evaluations are discussed for three cases of sinusoidal, staircaselike and Mateos ratchet potentials, also with the additional loads modelled by tilted potential structure. In addition, stochastic character of the kinetics is investigated by considering perturbation by Gaussian white noise which is shown to be responsible for driving the directionality of the asymptotic flux in the ratchet. This stochastically driven directionality effect is visualized as a strong nonmonotonic dependence of the statistics of the right versus left trajectories of motion leading to a net current of particles. Possible applications of the ratchet systems to molecular motors are also briefly discussed.

  13. Performance Estimation for Two-Dimensional Brownian Rotary Ratchet Systems

    Science.gov (United States)

    Tutu, Hiroki; Horita, Takehiko; Ouchi, Katsuya

    2015-04-01

    Within the context of the Brownian ratchet model, a molecular rotary system that can perform unidirectional rotations induced by linearly polarized ac fields and produce positive work under loads was studied. The model is based on the Langevin equation for a particle in a two-dimensional (2D) three-tooth ratchet potential of threefold symmetry. The performance of the system is characterized by the coercive torque, i.e., the strength of the load competing with the torque induced by the ac driving field, and the energy efficiency in force conversion from the driving field to the torque. We propose a master equation for coarse-grained states, which takes into account the boundary motion between states, and develop a kinetic description to estimate the mean angular momentum (MAM) and powers relevant to the energy balance equation. The framework of analysis incorporates several 2D characteristics and is applicable to a wide class of models of smooth 2D ratchet potential. We confirm that the obtained expressions for MAM, power, and efficiency of the model can enable us to predict qualitative behaviors. We also discuss the usefulness of the torque/power relationship for experimental analyses, and propose a characteristic for 2D ratchet systems.

  14. Dynamical analysis of an optical rocking ratchet: Theory and experiment

    Czech Academy of Sciences Publication Activity Database

    Arzola, Alejandro V.; Volke-Sepúlveda, K.; Mateos, J.L.

    2013-01-01

    Roč. 87, č. 6 (2013), 062910:1-9 ISSN 1539-3755 R&D Projects: GA MŠk LH12018; GA MŠk EE2.4.31.0016 Institutional support: RVO:68081731 Keywords : deterministic optical rocking ratchet * analysis of the dynamics Subject RIV: BH - Optics, Masers, Lasers Impact factor: 2.326, year: 2013

  15. Shock initiation experiments on ratchet grown PBX 9502

    Energy Technology Data Exchange (ETDEWEB)

    Gustavsen, Richard L [Los Alamos National Laboratory; Thompson, Darla G [Los Alamos National Laboratory; Olinger, Barton W [Los Alamos National Laboratory; Deluca, Racci [Los Alamos National Laboratory; Bartram, Brian D [Los Alamos National Laboratory; Pierce, Timothy H [Los Alamos National Laboratory; Sanchez, Nathaniel J [Los Alamos National Laboratory

    2010-01-01

    This study compares the shock initiation behavior of PBX 9502 pressed to less than nominal density (nominal density is 1.890 {+-} 0.005 g/cm{sup 3}) with PBX 9502 pressed to nominal density and then ''ratchet grown'' to low density. PBX 9502 is an insensitive plastic bonded explosive consisting of 95 weight % dry-aminated tri-amino-tri-nitro-benzene (TATB) and 5 weight % Kel-F 800 plastic binder. ''Ratchet growth'' - an irreversible increase in specific volume - occurs when an explosive based on TATB is temperature cycled. The design of our study is as follows: PBX 9502, all from the same lot, received the following four treatments. Samples in the first group were pressed to less than nominal density. These were not ratchet grown and used as a baseline. Samples in the second group were pressed to nominal density and then ratchet grown by temperature cycling 30 times between -54 C and +80 C. Samples in the final group were pressed to nominal density and cut into 100 mm by 25.4 mm diameter cylinders. During thermal cycling the cylinders were axially constrained by a 100 psi load. Samples for shock initiation experiments were cut perpendicular (disks) and parallel (slabs) to the axial load. The four sample groups can be summarized with the terms pressed low, ratchet grown/no load, axial load/disks, and axial load/slabs. All samples were shock initiated with nearly identical inputs in plate impact experiments carried out on a gas gun. Wave profiles were measured after propagation through 3, 4, 5, and 6 mm of explosive. Side by side comparison of wave profiles from different samples is used as a measure of relative sensitivity. All reduced density samples were more shock sensitive than nominal density PBX 9502. Differences in shock sensitivity between ratchet grown and pressed to low density PBX 9502 were small, but the low density pressings are slightly more sensitive than the ratchet grown samples.

  16. Dielectrophoretic capture and genetic analysis of single neuroblastoma tumor cells

    Directory of Open Access Journals (Sweden)

    Erica L Carpenter

    2014-07-01

    Full Text Available Our understanding of the diversity of cells that escape the primary tumor and seed micrometastases remains rudimentary, and approaches for studying circulating and disseminated tumor cells have been limited by low throughput and sensitivity, reliance on single parameter sorting, and a focus on enumeration rather than phenotypic and genetic characterization. Here we utilize a highly sensitive microfluidic and dielectrophoretic approach for the isolation and genetic analysis of individual tumor cells. We employed fluorescence labeling to isolate 208 single cells from spiking experiments conducted with 11 cell lines, including 8 neuroblastoma cell lines, and achieved a capture sensitivity of 1 tumor cell per 106 white blood cells. Sample fixation or freezing had no detectable effect on cell capture. Point mutations were accurately detected in the whole genome amplification product of captured single tumor cells but not in negative control white blood cells. We applied this approach to capture 144 single tumor cells from 10 bone marrow samples from patients suffering from neuroblastoma. In this pediatric malignancy, high-risk patients often exhibit wide-spread hematogenous metastasis, but access to primary tumor can be difficult or impossible. Here we used flow-based sorting to pre-enrich samples with tumor involvement below 0.02%. For all patients for whom a mutation in the Anaplastic Lymphoma Kinase gene had already been detected in their primary tumor, the same mutation was detected in single cells from their marrow. These findings demonstrate a novel, non-invasive, and adaptable method for the capture and genetic analysis of single tumor cells from cancer patients.

  17. Brownian ratchets from statistical physics to bio and nano-motors

    CERN Document Server

    Cubero, David

    2016-01-01

    Illustrating the development of Brownian ratchets, from their foundations, to their role in the description of life at the molecular scale and in the design of artificial nano-machinery, this text will appeal to both advanced graduates and researchers entering the field. Providing a self-contained introduction to Brownian ratchets, devices which rectify microscopic fluctuations, Part I avoids technicalities and sets out the broad range of physical systems where the concept of ratchets is relevant. Part II supplies a single source for a complete and modern theoretical analysis of ratchets in regimes such as classical vs quantum and stochastic vs deterministic, and in Part III readers are guided through experimental developments in different physical systems, each highlighting a specific unique feature of ratchets. The thorough and systematic approach to the topic ensures that this book provides a complete guide to Brownian ratchets for newcomers and established researchers in physics, biology and biochemistry.

  18. Experimental study on ratcheting of a cylinder subjected to axially moving temperature distribution

    International Nuclear Information System (INIS)

    Igari, T.; Yamauchi, M.; Wada, H.

    1989-01-01

    Development of a design of cylinder subjected to axially moving temperature distribution is very important in the design of the reactor vessel of fast breeder reactor containing high-temperature sodium. So far, however, a mechanism and a prediction method for this ratcheting have not been clarified. This paper proposes the ratcheting mechanism as well as the predictive equations of the ratcheting strain for the representative two temperature distributions. The proposed ratcheting mechanism was based on the hoop-membrane stress-strain behavior of the cylinder, and the movement of the temperature distribution was regarded as a driving force of this ratcheting. This paper describes the results of the experimental study on the proposed ratcheting mechanism and the predictive equations

  19. Evaluation of thermal ratcheting of reactor vessel wall near the sodium surface

    International Nuclear Information System (INIS)

    Take, Kohji; Fujioka, Terutaka; Yano, Kazutaka

    1989-01-01

    Plastic ratcheting of reactor vessels may occur by an axially moving thermal gradient without primary stress. So there is a need to establish a proper prediction method for the plastic ratcheting. In this study, inelastic FEM analyses of reactor vessel model by using an advanced constitutive equation were carried out in order to comprehend plastic ratcheting behaviour of cylinder which subject to an axially moving thermal gradient. As a result of analyses, a basic mechanism of this ratcheting was found. And it also indicated that cyclic hardening behaviour will became important for development of evaluation method. (author)

  20. Clarification of strain limits considering the ratcheting fatigue strength of 316FR steel

    International Nuclear Information System (INIS)

    Isobe, Nobuhiro; Sukekawa, Masayuki; Nakayama, Yasunari; Date, Shingo; Ohtani, Tomomi; Takahashi, Yukio; Kasahara, Naoto; Shibamoto, Hiroshi; Nagashima, Hideaki; Inoue, Kazuhiko

    2008-01-01

    The effect of ratcheting on fatigue strength was investigated in order to rationalize the strain limit as a design criterion of commercialized fast reactor systems. Ratcheting fatigue tests were conducted at 550 deg. Duration of the ratchet straining was set for a certain number of strain cycles taking the loading condition of fast reactors into account, and the number of cycles for strain accumulation was defined as the ratchet-expired cycle. Fatigue lives decrease as the accumulated strain by ratcheting increases. Mean stress increased during the ratcheting cycle and its maximum value depended on the accumulated strain and the ratchet-expired cycle. Fatigue life reduction was negligible when the maximum mean stress was less than 25 MPa, corresponding to an accumulated strain of 2.2%. Accumulated strain is limited to 2% in the present design guidelines and this strain limit is considered effective to avoid reducing fatigue life by ratcheting. Microcrack growth behaviors were also investigated in these tests in order to discuss the life reduction mechanisms in ratcheting conditions

  1. Constitutive modeling for uniaxial time-dependent ratcheting of SS304 stainless steel

    International Nuclear Information System (INIS)

    Kan Qianhua; Kang Guozheng; Zhang Juan

    2007-01-01

    Based on the experimental results of uniaxial time-dependent ratcheting behavior of SS304 stainless steel at room temperature and 973K, a new time-dependent constitutive model was proposed. The model describes the time-dependent ratcheting by adding a static/thermal recovery into the Abdel-Karim-Ohno non-linear kinematic hardening rule. The capability of the model to describe the time-dependent ratcheting was discussed by comparing the simulations with the corresponding experimental results. It is shown that the revised unified viscoplastic model can simulate the time-dependent ratcheting reasonably both at room and high temperatures. (authors)

  2. Ratchetting deformation behavior of modified 9Cr-1Mo steel and applicability of existing constitutive models

    International Nuclear Information System (INIS)

    Yaguchi, Masatsugu; Takahashi, Yukio

    2001-01-01

    A series of ratchetting deformation tests was conducted on modified 9Cr-1Mo steel at 550degC under uniaxial and multiaxial stress conditions. Ratchetting behavior depended on various parameters such as mean stress, stress/strain rate and those range, hold time and prior cyclic deformation. Under uniaxial conditions, untraditional ratchetting behavior was observed; the ratchetting deformation rate was the fastest when the stress ratio was equal to -1, while no ratchetting deformation was predicted by conventional constitutive models. In order to discuss the reason for this untraditional ratchetting behavior, a lot of monotonic compression tests were conducted and compared with tension data. The material showed a difference of deformation resistance of about 30 MPa between tension and compression at high strain rates. Furthermore, the authors' previous model and Ohno-Wang model were applied to the test conditions to evaluate their description capability for ratchetting behavior of the material. It was shown that the authors' model has a tendency to overestimate the ratchetting deformation and that the Ohno-Wang model has a tendency to underestimate the uniaxial ratchetting deformation at small stress rates. (author)

  3. Solution of the ratchet-shakedown Bree problem with an extra orthogonal primary load

    International Nuclear Information System (INIS)

    Bradford, R.A.W.

    2015-01-01

    The complete shakedown and ratcheting solution is derived analytically for a flat plate subject to unequal biaxial primary membrane stresses and a cyclic secondary bending stress in one in-plane direction (x). The Tresca yield condition and elastic-perfectly plastic behaviour are assumed. It is shown that the results can be expressed in the form of a “universal” ratchet diagram applicable for all magnitudes of orthogonal load. For sufficiently large cyclic bending stresses, tensile ratcheting can occur in the x direction if the x direction primary membrane stress exceeds half that in the orthogonal direction. Conversely, for sufficiently large cyclic bending stresses ratcheting in the x direction will be compressive if the x direction primary membrane stress is less than half that in the orthogonal direction. When the x direction primary membrane stress is exactly half that in the orthogonal direction ratcheting cannot occur however large the cyclic secondary bending stress. - Highlights: • A complete shakedown and ratcheting solution is derived analytically. • The problem is Bree-like but with an extra orthogonal primary load. • The ratchet diagram can be expressed in a form applicable to any orthogonal load. • Tensile ratcheting can occur if the primary load exceeds half the orthogonal load. • Compressive ratcheting can occur for smaller primary loads

  4. High-throughput particle manipulation by hydrodynamic, electrokinetic, and dielectrophoretic effects in an integrated microfluidic chip

    KAUST Repository

    Li, Shunbo; Li, Ming; Bougot-Robin, Kristelle; Cao, Wenbin; Yeung Yeung Chau, Irene; Li, Weihua; Wen, Weijia

    2013-01-01

    Integrating different steps on a chip for cell manipulations and sample preparation is of foremost importance to fully take advantage of microfluidic possibilities, and therefore make tests faster, cheaper and more accurate. We demonstrated particle manipulation in an integrated microfluidic device by applying hydrodynamic, electroosmotic (EO), electrophoretic (EP), and dielectrophoretic (DEP) forces. The process involves generation of fluid flow by pressure difference, particle trapping by DEP force, and particle redirect by EO and EP forces. Both DC and AC signals were applied, taking advantages of DC EP, EO and AC DEP for on-chip particle manipulation. Since different types of particles respond differently to these signals, variations of DC and AC signals are capable to handle complex and highly variable colloidal and biological samples. The proposed technique can operate in a high-throughput manner with thirteen independent channels in radial directions for enrichment and separation in microfluidic chip. We evaluated our approach by collecting Polystyrene particles, yeast cells, and E. coli bacteria, which respond differently to electric field gradient. Live and dead yeast cells were separated successfully, validating the capability of our device to separate highly similar cells. Our results showed that this technique could achieve fast pre-concentration of colloidal particles and cells and separation of cells depending on their vitality. Hydrodynamic, DC electrophoretic and DC electroosmotic forces were used together instead of syringe pump to achieve sufficient fluid flow and particle mobility for particle trapping and sorting. By eliminating bulky mechanical pumps, this new technique has wide applications for in situ detection and analysis.

  5. High-throughput particle manipulation by hydrodynamic, electrokinetic, and dielectrophoretic effects in an integrated microfluidic chip

    KAUST Repository

    Li, Shunbo

    2013-03-20

    Integrating different steps on a chip for cell manipulations and sample preparation is of foremost importance to fully take advantage of microfluidic possibilities, and therefore make tests faster, cheaper and more accurate. We demonstrated particle manipulation in an integrated microfluidic device by applying hydrodynamic, electroosmotic (EO), electrophoretic (EP), and dielectrophoretic (DEP) forces. The process involves generation of fluid flow by pressure difference, particle trapping by DEP force, and particle redirect by EO and EP forces. Both DC and AC signals were applied, taking advantages of DC EP, EO and AC DEP for on-chip particle manipulation. Since different types of particles respond differently to these signals, variations of DC and AC signals are capable to handle complex and highly variable colloidal and biological samples. The proposed technique can operate in a high-throughput manner with thirteen independent channels in radial directions for enrichment and separation in microfluidic chip. We evaluated our approach by collecting Polystyrene particles, yeast cells, and E. coli bacteria, which respond differently to electric field gradient. Live and dead yeast cells were separated successfully, validating the capability of our device to separate highly similar cells. Our results showed that this technique could achieve fast pre-concentration of colloidal particles and cells and separation of cells depending on their vitality. Hydrodynamic, DC electrophoretic and DC electroosmotic forces were used together instead of syringe pump to achieve sufficient fluid flow and particle mobility for particle trapping and sorting. By eliminating bulky mechanical pumps, this new technique has wide applications for in situ detection and analysis.

  6. Pattern formation in plastic liquid films on elastomers by ratcheting.

    Science.gov (United States)

    Huang, Jiangshui; Yang, Jiawei; Jin, Lihua; Clarke, David R; Suo, Zhigang

    2016-04-20

    Plastic liquids, also known as Bingham liquids, retain their shape when loads are small, but flow when loads exceed a threshold. We discovered that plastic liquid films coated on elastomers develop wavy patterns under cyclic loads. As the number of cycles increases, the wavelength of the patterns remains unchanged, but the amplitude of the patterns increases and then saturates. Because the patterns develop progressively under cyclic loads, we call this phenomenon as "patterning by ratcheting". We observe the phenomenon in plastic liquids of several kinds, and studied the effects of thickness, the cyclic frequency of the stretch, and the range of the stretch. Finite element simulations show that the ratcheting phenomenon can occur in materials described by a commonly used model of elastic-plastic deformation.

  7. Uniaxial ratcheting behavior of sintered nanosilver joint for electronic packaging

    International Nuclear Information System (INIS)

    Chen, Gang; Yu, Lin; Mei, Yunhui; Li, Xin; Chen, Xu; Lu, Guo-Quan

    2014-01-01

    Uniaxial ratcheting behavior and the fatigue life of sintered nanosilver joint were investigated at room temperature. All tests were carried out under stress-controlled mode. Force–displacement data were recorded during the entire fatigue lifespan by a non-contact displacement detecting system. Effects of stress amplitude, mean stress, stress rate, and stress ratio on the uniaxial ratcheting behavior of the sintered nanosilver joint were discussed. Stress-life (S–N) curves of the sintered joints were also obtained. The Smith–Watson–Topper (SWT) model, the Gerber model and the modified Goodman model, all of which took effect of mean stress into consideration, were compared for predicting the fatigue life of the sintered joint. Both the ratcheting strain and its rate increased with increasing stress amplitude or mean stress. The increase in stress amplitude and mean stress both reduced the fatigue life of the sintered joint, while the fatigue life prolonged with the increase in stress rate and stress ratio. The modified Goodman model predicted the fatigue life of the sintered joints well

  8. Atomistic study of a nanometer-scale pump based on the thermal ratchet concept

    DEFF Research Database (Denmark)

    Oyarzua, Elton; Walther, J. H.; Zambrano, Harvey

    In this study, a novel concept of nanoscale pump fabricated using Carbon Nanotubes (CNTs) is presented. The development of nanofluidic systems provides unprecedented possibilities for the control of biology and chemistry at the molecular level with potential applications in low energy cost devices...... dynamics simulations, we explore the possibility to design thermophoretic pumping devices fabricated of CNTs for water transport in nanoconduits. The design of the nanopumps is based on the concept of the Feynman-Smoluchowski ratchet....... of great interest in nanofluidics. Thermophoresisis the phenomenon observed when a mixture of two or more types of motile objects experience a force induced by a thermal gradient and the different types of objects respond to it differently, inducing a motion and segregation of the objects. Using molecular...

  9. Cyclic mechanical behavior of 316L: Uniaxial LCF and strain-controlled ratcheting tests

    International Nuclear Information System (INIS)

    Facheris, G.; Janssens, K.G.F.

    2013-01-01

    Highlights: ► Characterization of cyclic plastic deformation behavior of plate and tubular 316L. ► Strain-controlled ratcheting response between room temperature and 200 °C. ► Isotropic cyclic hardening is dependent on the yield criterion used. ► Ratcheting induced hardening mostly affects the kinematic hardening component. ► Ratcheting induced hardening is related to the mean strain and the ratcheting rate. -- Abstract: With the purpose of analyzing the fatigue behavior under loading conditions relevant for the primary cooling circuit of a light water nuclear reactor, a set of uniaxial low cycle fatigue and strain-controlled ratcheting tests (also named ‘cyclic tension tests’) has been performed at room temperature and at 200 °C on specimens manufactured from two different batches of stainless steel grade 316L. The experiments have been repeated varying strain amplitude, cyclic ratcheting rate and ratcheting direction in order to investigate the influence on the cyclic deformation behavior. In strain-controlled ratcheting tests, the stress response is found to be a superposition of two hardening mechanisms: the first one due to the zero mean strain cycling and the second one linked with the monotonic drifting of mean plastic strain. An approach is proposed to distinguish the effect of each mechanism and the influence of the test parameters on the hardening mechanisms is discussed

  10. Test and analysis of thermal ratcheting deformation for 316L stainless steel cylindrical structure

    International Nuclear Information System (INIS)

    Lee, Hyeong Yeon; Kim, Jong Bum; Lee, Jae Han

    2002-01-01

    In this study, the progressive inelastic deformation, so called, thermal ratchet phenomenon which can occur in high temperature structures of liquid metal simulated with thermal ratchet structural test facility and 316L stainless steel test cylinder. The thermal ratchet deformation at the reactor baffle cylinder of the liquid metal reactor can occur due to the moving temperature distribution along the axial direction as the sodium free surface moves up and down under the cyclic heat-up and cool-down transients. The ratchet deformation was measured with the laser displacement sensor and LVDTs after cooling the structural specimen which is heated up to 550 degree C with steep temperature gradients along the axial direction. The temperature distribution of the test cylinder along the axial direction was measured with 28 channels of thermocouples and was used for the ratchet analysis. The thermal ratchet deformation was analyzed with the constitutive equation of nonlinear combined hardening model which was implemented as ABAQUS user subroutine and the analysis results were compared with those of the test. Thermal ratchet load was applied 9 times and the residual displacement after 9 cycles of thermal load was measured to be 1.79 mm. The ratcheting deformation shapes obtained by the analysis with the combined hardening model were in reasonable agreement with those of the structural tests

  11. A study on thermal ratcheting structure test of 316L test cylinder

    International Nuclear Information System (INIS)

    Lee, H. Y.; Kim, J. B.; Koo, G. H.

    2001-01-01

    In this study, the progressive inelastic deformation, so called, thermal ratchet phenomenon which can occur in high temperature liquid metal reactor was simulated with thermal ratchet structural test facility and 316L stainless steel test cylinder. The inelastic deformation of the reactor baffle cylinder can occur due to the moving temperature distribution along the axial direction as the hot free surface moves up and down under the cyclic heat-up and cool-down of reactor operations. The ratchet deformations were measured with the laser displacement sensor and LVDTs after cooling the structural specimen which experiences thermal load up to 550 .deg. C and the temperature differences of about 500 .deg. C. During structural thermal ratchet test, the temperature distribution of the test cylinder along the axial direction was measured from 28 channels of thermocouples and the temperatures were used for the ratchet analysis. The thermal ratchet deformation analysis was performed with the NONSTA code whose constitutive model is nonlinear combined kinematic and isotropic hardening model and the test results were compared with those of the analysis. Thermal ratchet test was carried out with respect to 9 cycles of thermal loading and the maximum residual displacements were measured to be 1.8mm. It was shown that thermal ratchet load can cause a progressive deformation to the reactor structure. The analysis results with the combined hardening model were in reasonable agreement with those of the tests

  12. Dielectrophoretic self-assembly of polarized light emitting poly(9,9-dioctylfluorene) nanofibre arrays

    International Nuclear Information System (INIS)

    O'Riordan, A; Iacopino, D; Lovera, P; Floyd, L; Reynolds, K; Redmond, G

    2011-01-01

    Conjugated polymer based 1D nanostructures are attractive building blocks for future opto-electronic nanoscale devices and systems. However, a critical challenge remains the lack of manipulation methods that enable controlled and reliable positioning and orientation of organic nanostructures in a fast, reliable and scalable manner. To address this challenge, we explore dielectrophoretic assembly of discrete poly(9,9-dioctylfluorene) nanofibres and demonstrate site selective assembly and orientation of these fibres. Nanofibre arrays were assembled preferentially at receptor electrode edges, being aligned parallel to the applied electric field with a high order parameter fit (∼0.9) and exhibiting an emission dichroic ratio of ∼ 4.0. As such, the dielectrophoretic method represents a fast, reliable and scalable self-assembly approach for manipulation of 1D organic nanostructures. The ability to fabricate nanofibre arrays in this manner could be potentially important for exploration and development of future nanoscale opto-electronic devices and systems.

  13. Self assembly of organic nanostructures and dielectrophoretic assembly of inorganic nanowires.

    Science.gov (United States)

    Dholakia, Geetha; Kuo, Steven; Allen, E. L.

    2007-03-01

    Self assembly techniques enable the organization of organic molecules into nanostructures. Currently engineering strategies for efficient assembly and routine integration of inorganic nanoscale objects into functional devices is very limited. AC Dielectrophoresis is an efficient technique to manipulate inorganic nanomaterials into higher dimensional structures. We used an alumina template based sol-gel synthesis method for the growth of various metal oxide nanowires with typical diameters of 100-150 nm, ranging in length from 3-10 μm. Here we report the dielectrophoretic assembly of TiO2 nanowires, an important material for photocatalysis and photovoltaics, onto interdigitated devices. Self assembly in organic nanostructures and its dependence on structure and stereochemistry of the molecule and dielectrophoretic field dependence in the assembly of inorganic nanowires will be compared and contrasted. Tunneling spectroscopy and DOS of these nanoscale systems will also be discussed.

  14. Controlled dielectrophoretic nanowire self-assembly using atomic layer deposition and suspended microfabricated electrodes

    International Nuclear Information System (INIS)

    Baca, Alicia I; Brown, Joseph J; Bright, Victor M; Bertness, Kris A

    2012-01-01

    Effects of design and materials on the dielectrophoretic self-assembly of individual gallium nitride nanowires (GaN NWs) onto microfabricated electrodes have been experimentally investigated. The use of TiO 2 surface coating generated by atomic layer deposition (ALD) improves dielectrophoretic assembly yield of individual GaN nanowires on microfabricated structures by as much as 67%. With a titanium dioxide coating, individual nanowires were placed across suspended electrode pairs in 46% of tests (147 out of 320 total), versus 28% of tests (88 out of 320 total tests) that used uncoated GaN NWs. An additional result from these tests was that suspending the electrodes 2.75 μm above the substrate corresponded with up to 15.8% improvement in overall assembly yield over that of electrodes fabricated directly on the substrate. (paper)

  15. Regional Atmospheric Transport Code for Hanford Emission Tracking, Version 2 (RATCHET2)

    International Nuclear Information System (INIS)

    Ramsdell, James V.; Rishel, Jeremy P.

    2006-01-01

    This manual describes the atmospheric model and computer code for the Atmospheric Transport Module within SAC. The Atmospheric Transport Module, called RATCHET2, calculates the time-integrated air concentration and surface deposition of airborne contaminants to the soil. The RATCHET2 code is an adaptation of the Regional Atmospheric Transport Code for Hanford Emissions Tracking (RATCHET). The original RATCHET code was developed to perform the atmospheric transport for the Hanford Environmental Dose Reconstruction Project. Fundamentally, the two sets of codes are identical; no capabilities have been deleted from the original version of RATCHET. Most modifications are generally limited to revision of the run-specification file to streamline the simulation process for SAC.

  16. Regional Atmospheric Transport Code for Hanford Emission Tracking, Version 2(RATCHET2)

    Energy Technology Data Exchange (ETDEWEB)

    Ramsdell, James V.; Rishel, Jeremy P.

    2006-07-01

    This manual describes the atmospheric model and computer code for the Atmospheric Transport Module within SAC. The Atmospheric Transport Module, called RATCHET2, calculates the time-integrated air concentration and surface deposition of airborne contaminants to the soil. The RATCHET2 code is an adaptation of the Regional Atmospheric Transport Code for Hanford Emissions Tracking (RATCHET). The original RATCHET code was developed to perform the atmospheric transport for the Hanford Environmental Dose Reconstruction Project. Fundamentally, the two sets of codes are identical; no capabilities have been deleted from the original version of RATCHET. Most modifications are generally limited to revision of the run-specification file to streamline the simulation process for SAC.

  17. Ductility, strength and hardness relation after prior incremental deformation (ratcheting) of austenitic steel

    International Nuclear Information System (INIS)

    Kussmaul, K.; Diem, H.K.; Wachter, O.

    1993-01-01

    Experimental investigations into the stress/strain behavior of the niobium stabilized austenitic material with the German notation X6 CrNiNb 18 10 proved that a limited incrementally applied prior deformation will reduce the total deformation capability only by the amount of the prior deformation. It could especially be determined on the little changes in the reduction of area that the basically ductile deformation behavior will not be changed by the type of the prior loading. There is a correlation between the amount of deformation and the increase in hardness. It is possible to correlate both the changes in hardness and the material properties. In the case of low cycle fatigue tests with alternating temperature an incremental increase in total strain (ratcheting) was noted to depend on the strain range applied

  18. Hubble Space Telescope EVA Power Ratchet Tool redesign

    Science.gov (United States)

    Richards, Paul W.; Park, Chan; Brown, Lee

    The Power Ratchet Tool (PRT) is a self contained, power-driven, 3/8 inch drive ratchet wrench which will be used by astronauts during Extravehicular Activities (EVA). This battery-powered tool is controlled by a dedicated electonic controller. The PRT was flown during the Hubble Space Telescope (HST) Deployment Mission STS-31 to deploy the solar arrays if the automatic mechanisms failed. The PRT is currently intended for use during the first HST Servicing Mission STS-61 as a general purpose power tool. The PRT consists of three major components; the wrench, the controller, and the battery module. Fourteen discrete combinations of torque, turns, and speed may be programmed into the controller before the EVA. The crewmember selects the desired parameter profile by a switch mounted on the controller. The tool may also be used in the manual mode as a non-powered ratchet wrench. The power is provided by a silver-zinc battery module, which fits into the controller and is replaceable during an EVA. The original PRT did not meet the design specification of torque output and hours of operation. To increase efficiency and reliability the PRT underwent a redesign effort. The majority of this effort focused on the wrench. The original PRT drive train consisted of a low torque, high speed brushless DC motor, a face gear set, and a planocentric gear assembly. The total gear reduction was 300:1. The new PRT wrench consists of a low speed, high torque brushless DC motor, two planetary gear sets and a bevel gear set. The total gear reduction is now 75:1. A spline clutch has also been added to disengage the drive train in the manual mode. The design changes to the controller will consist of only those modifications necessary to accomodate the redesigned wrench.

  19. Regional Atmospheric Transport Code for Hanford Emission Tracking (RATCHET)

    International Nuclear Information System (INIS)

    Ramsdell, J.V. Jr.; Simonen, C.A.; Burk, K.W.

    1994-02-01

    The purpose of the Hanford Environmental Dose Reconstruction (HEDR) Project is to estimate radiation doses that individuals may have received from operations at the Hanford Site since 1944. This report deals specifically with the atmospheric transport model, Regional Atmospheric Transport Code for Hanford Emission Tracking (RATCHET). RATCHET is a major rework of the MESOILT2 model used in the first phase of the HEDR Project; only the bookkeeping framework escaped major changes. Changes to the code include (1) significant changes in the representation of atmospheric processes and (2) incorporation of Monte Carlo methods for representing uncertainty in input data, model parameters, and coefficients. To a large extent, the revisions to the model are based on recommendations of a peer working group that met in March 1991. Technical bases for other portions of the atmospheric transport model are addressed in two other documents. This report has three major sections: a description of the model, a user's guide, and a programmer's guide. These sections discuss RATCHET from three different perspectives. The first provides a technical description of the code with emphasis on details such as the representation of the model domain, the data required by the model, and the equations used to make the model calculations. The technical description is followed by a user's guide to the model with emphasis on running the code. The user's guide contains information about the model input and output. The third section is a programmer's guide to the code. It discusses the hardware and software required to run the code. The programmer's guide also discusses program structure and each of the program elements

  20. Entropic Ratchet transport of interacting active Brownian particles

    International Nuclear Information System (INIS)

    Ai, Bao-Quan; He, Ya-Feng; Zhong, Wei-Rong

    2014-01-01

    Directed transport of interacting active (self-propelled) Brownian particles is numerically investigated in confined geometries (entropic barriers). The self-propelled velocity can break thermodynamical equilibrium and induce the directed transport. It is found that the interaction between active particles can greatly affect the ratchet transport. For attractive particles, on increasing the interaction strength, the average velocity first decreases to its minima, then increases, and finally decreases to zero. For repulsive particles, when the interaction is very weak, there exists a critical interaction at which the average velocity is minimal, nearly tends to zero, however, for the strong interaction, the average velocity is independent of the interaction

  1. Entropic Ratchet transport of interacting active Brownian particles

    Energy Technology Data Exchange (ETDEWEB)

    Ai, Bao-Quan, E-mail: aibq@hotmail.com [Laboratory of Quantum Engineering and Quantum Materials, School of Physics and Telecommunication Engineering, South China Normal University, 510006 Guangzhou (China); He, Ya-Feng [College of Physics Science and Technology, Hebei University, 071002 Baoding (China); Zhong, Wei-Rong, E-mail: wrzhong@jnu.edu.cn [Department of Physics and Siyuan Laboratory, College of Science and Engineering, Jinan University, 510632 Guangzhou (China)

    2014-11-21

    Directed transport of interacting active (self-propelled) Brownian particles is numerically investigated in confined geometries (entropic barriers). The self-propelled velocity can break thermodynamical equilibrium and induce the directed transport. It is found that the interaction between active particles can greatly affect the ratchet transport. For attractive particles, on increasing the interaction strength, the average velocity first decreases to its minima, then increases, and finally decreases to zero. For repulsive particles, when the interaction is very weak, there exists a critical interaction at which the average velocity is minimal, nearly tends to zero, however, for the strong interaction, the average velocity is independent of the interaction.

  2. Ratchet effect for nanoparticle transport in hair follicles.

    Science.gov (United States)

    Radtke, Matthias; Patzelt, Alexa; Knorr, Fanny; Lademann, Jürgen; Netz, Roland R

    2017-07-01

    The motion of a single rigid nanoparticle inside a hair follicle is investigated by means of Brownian dynamics simulations. The cuticular hair structure is modeled as a periodic asymmetric ratchet-shaped surface. Induced by oscillating radial hair motion we find directed nanoparticle transport into the hair follicle with maximal velocity at a specific optimal frequency and an optimal particle size. We observe flow reversal when switching from radial to axial oscillatory hair motion. We also study the diffusion behavior and find strongly enhanced diffusion for axial motion with a diffusivity significantly larger than for free diffusion. Copyright © 2016 Elsevier B.V. All rights reserved.

  3. Giant transversal particle diffusion in a longitudinal magnetic ratchet.

    Science.gov (United States)

    Tierno, Pietro; Reimann, Peter; Johansen, Tom H; Sagués, Francesc

    2010-12-03

    We study the transversal motion of paramagnetic particles on a uniaxial garnet film, exhibiting a longitudinal ratchet effect in the presence of an oscillating magnetic field. Without the field, the thermal diffusion coefficient obtained by video microscopy is D(0) ≈ 3 × 10(-4)  μm2/s. With the field, the transversal diffusion exhibits a giant enhancement by almost four decades and a pronounced maximum as a function of the driving frequency. We explain the experimental findings with a theoretical interpretation in terms of random disorder effects within the magnetic film.

  4. Polarizability of Six-Helix Bundle and Triangle DNA Origami and Their Escape Characteristics from a Dielectrophoretic Trap.

    Science.gov (United States)

    Gan, Lin; Camacho-Alanis, Fernanda; Ros, Alexandra

    2015-12-15

    DNA nanoassemblies, such as DNA origamis, hold promise in biosensing, drug delivery, nanoelectronic circuits, and biological computing, which require suitable methods for migration and precision positioning. Insulator-based dielectrophoresis (iDEP) has been demonstrated as a powerful migration and trapping tool for μm- and nm-sized colloids as well as DNA origamis. However, little is known about the polarizability of origami species, which is responsible for their dielectrophoretic migration. Here, we report the experimentally determined polarizabilities of the six-helix bundle origami (6HxB) and triangle origami by measuring the migration times through a potential landscape exhibiting dielectrophoretic barriers. The resulting migration times correlate to the depth of the dielectrophoretic potential barrier and the escape characteristics of the origami according to an adapted Kramer's rate model, allowing their polarizabilities to be determined. We found that the 6HxB polarizability is larger than that of the triangle origami, which correlates with the variations in charge density of both origamis. Further, we discuss the orientation of both origami species in the dielectrophoretic trap and discuss the influence of diffusion during the escape process. Our study provides detailed insight into the factors contributing to the migration through dielectrophoretic potential landscapes, which can be exploited for applications with DNA and other nanoassemblies based on dielectrophoresis.

  5. Quantum ratchet effect in a time non-uniform double-kicked model

    Science.gov (United States)

    Chen, Lei; Wang, Zhen-Yu; Hui, Wu; Chu, Cheng-Yu; Chai, Ji-Min; Xiao, Jin; Zhao, Yu; Ma, Jin-Xiang

    2017-07-01

    The quantum ratchet effect means that the directed transport emerges in a quantum system without a net force. The delta-kicked model is a quantum Hamiltonian model for the quantum ratchet effect. This paper investigates the quantum ratchet effect based on a time non-uniform double-kicked model, in which two flashing potentials alternately act on a particle with a homogeneous initial state of zero momentum, while the intervals between adjacent actions are not equal. The evolution equation of the state of the particle is derived from its Schrödinger equation, and the numerical method to solve the evolution equation is pointed out. The results show that quantum resonances can induce the ratchet effect in this time non-uniform double-kicked model under certain conditions; some quantum resonances, which cannot induce the ratchet effect in previous models, can induce the ratchet effect in this model, and the strengths of the ratchet effect in this model are stronger than those in previous models under certain conditions. These results enrich people’s understanding of the delta-kicked model, and provides a new optional scheme to control the quantum transport of cold atoms in experiment.

  6. Electric generation and ratcheted transport of contact-charged drops

    Science.gov (United States)

    Cartier, Charles A.; Graybill, Jason R.; Bishop, Kyle J. M.

    2017-10-01

    We describe a simple microfluidic system that enables the steady generation and efficient transport of aqueous drops using only a constant voltage input. Drop generation is achieved through an electrohydrodynamic dripping mechanism by which conductive drops grow and detach from a grounded nozzle in response to an electric field. The now-charged drops are transported down a ratcheted channel by contact charge electrophoresis powered by the same voltage input used for drop generation. We investigate how the drop size, generation frequency, and transport velocity depend on system parameters such as the liquid viscosity, interfacial tension, applied voltage, and channel dimensions. The observed trends are well explained by a series of scaling analyses that provide insight into the dominant physical mechanisms underlying drop generation and ratcheted transport. We identify the conditions necessary for achieving reliable operation and discuss the various modes of failure that can arise when these conditions are violated. Our results demonstrate that simple electric inputs can power increasingly complex droplet operations with potential opportunities for inexpensive and portable microfluidic systems.

  7. Ratchet baryogenesis and an analogy with the forced pendulum

    Science.gov (United States)

    Bamba, Kazuharu; Barrie, Neil D.; Sugamoto, Akio; Takeuchi, Tatsu; Yamashita, Kimiko

    2018-06-01

    A new scenario of baryogenesis via the ratchet mechanism is proposed based on an analogy with the forced pendulum. The oscillation of the inflaton field during the reheating epoch after inflation plays the role of the driving force, while the phase 𝜃 of a scalar baryon field (a complex scalar field with baryon number) plays the role of the angle of the pendulum. When the inflaton is coupled to the scalar baryon, the behavior of the phase 𝜃 can be analogous to that of the angle of the forced pendulum. If the oscillation of the driving force is adjusted to the pendulum’s motion, a directed rotation of the pendulum is obtained with a nonvanishing value of 𝜃˙, which models successful baryogenesis since 𝜃˙ is proportional to the baryon number density. Similar ratchet models which lead to directed motion have been used in the study of molecular motors in biology. There, the driving force is supplied by chemical reactions, while in our scenario this role is played by the inflaton during the reheating epoch.

  8. Microfabricated ratchet structures for concentrating and patterning motile bacterial cells

    International Nuclear Information System (INIS)

    Kim, Sang Yub; Lee, Eun Se; Lee, Ho Jae; Lee, Se Yeon; Lee, Sung Kuk; Kim, Taesung

    2010-01-01

    We present a novel microfabricated concentrator for Escherichia coli that can be a stand-alone and self-contained microfluidic device because it utilizes the motility of cells. First of all, we characterize the motility of E. coli cells and various ratcheting structures that can guide cells to move in a desired direction in straight and circular channels. Then, we combine these ratcheting microstructures with the intrinsic tendency of cells to swim on the right side in microchannels to enhance the concentration rates up to 180 fold until the concentrators are fully filled with cells. Furthermore, we demonstrate that cells can be positioned and concentrated with a constant spacing distance on a surface, allowing spatial patterning of motile cells. These results can be applied to biosorption or biosensor devices that are powered by motile cells because they can be highly concentrated without any external mechanical and electrical energy sources. Hence, we believe that the concentrator design holds considerable potential to be applied for concentrating and patterning other motile microbes and providing a versatile structure for motility study of bacterial cells.

  9. Forespore engulfment mediated by a ratchet-like mechanism.

    Science.gov (United States)

    Broder, Dan H; Pogliano, Kit

    2006-09-08

    A key step in bacterial endospore formation is engulfment, during which one bacterial cell engulfs another in a phagocytosis-like process that normally requires SpoIID, SpoIIM, and SpoIIP (DMP). We here describe a second mechanism involving the zipper-like interaction between the forespore protein SpoIIQ and its mother cell ligand SpoIIIAH, which are essential for engulfment when DMP activity is reduced or SpoIIB is absent. They are also required for the rapid engulfment observed during the enzymatic removal of peptidoglycan, a process that does not require DMP. These results suggest the existence of two separate engulfment machineries that compensate for one another in intact cells, thereby rendering engulfment robust. Photobleaching analysis demonstrates that SpoIIQ assembles a stationary structure, suggesting that SpoIIQ and SpoIIIAH function as a ratchet that renders forward membrane movement irreversible. We suggest that ratchet-mediated engulfment minimizes the utilization of chemical energy during this dramatic cellular reorganization, which occurs during starvation.

  10. Prediction method for thermal ratcheting of a cylinder subjected to axially moving temperature distribution

    International Nuclear Information System (INIS)

    Wada, Hiroshi; Igari, Toshihide; Kitade, Shoji.

    1989-01-01

    A prediction method was proposed for plastic ratcheting of a cylinder, which was subjected to axially moving temperature distribution without primary stress. First, a mechanism of this ratcheting was proposed, which considered the movement of temperature distribution as a driving force of this phenomenon. Predictive equations of the ratcheting strain for two representative temperature distributions were proposed based on this mechanism by assuming the elastic-perfectly-plastic material behavior. Secondly, an elastic-plastic analysis was made on a cylinder subjected to the representative two temperature distributions. Analytical results coincided well with the predicted results, and the applicability of the proposed equations was confirmed. (author)

  11. Evaluation of fatigue-ratcheting damage of a pressurised elbow undergoing damage seismic inputs

    International Nuclear Information System (INIS)

    Dang Van, K.

    2000-01-01

    We present a simplified method to calculate the plastic ratchet of elbow-shaped pipes submitted to seismic loading and an internal pressure. This method is simplified in the sense that the value of the ratchet is obtained without the use of finite element method (FEM) calculations. Here we derive a formula and use it to evaluate the fatigue-ratcheting damage of an elbow. This approach is applicable to complex plastic response appropriately described by non-linear kinematics hardening, which is more realistic for stainless steel such as 316-L. (orig.)

  12. Control-oriented approaches to anticipating synchronization of chaotic deterministic ratchets

    Energy Technology Data Exchange (ETDEWEB)

    Xu Shiyun [State Key Lab for Turbulence and Complex Systems, Department of Mechanics and Aerospace Engineering, College of Engineering, Peking University, Beijing 100871 (China)], E-mail: xushiyun@pku.edu.cn; Yang Ying [State Key Lab for Turbulence and Complex Systems, Department of Mechanics and Aerospace Engineering, College of Engineering, Peking University, Beijing 100871 (China)], E-mail: yy@mech.pku.edu.cn; Song Lei [State Key Lab for Turbulence and Complex Systems, Department of Mechanics and Aerospace Engineering, College of Engineering, Peking University, Beijing 100871 (China)

    2009-06-15

    In virtue of techniques derived from nonlinear control system theory, we establish conditions under which one could obtain anticipating synchronization between two periodically driven deterministic ratchets that are able to exhibit directed transport with a finite velocity. Criteria are established in order to guarantee the anticipating synchronization property of such systems as well as characterize phase space dynamics of the ratchet transporting behaviors. These results allow one to predict the chaotic direct transport features of particles on a ratchet potential using a copy of the same system that performs as a slave, which are verified through numerical simulation.

  13. Ratcheting deformation of advanced 316 steel under creep-plasticity condition

    Energy Technology Data Exchange (ETDEWEB)

    Kawashima, Fumiko; Ishikawa, Akiyoshi; Asada, Yasuhide [Tokai Univ., Tokyo (Japan). Dept. of Mechanical Engineering

    1998-11-01

    Tension-torsion biaxial ratcheting tests have been conducted with Advanced 316 Steel (316FR Steel) at 650 C under a cyclic strain rate of 10{sup -3} to 10{sup -5} s{sup -1}. Accumulation of ratcheting strain has been measured. Accumulated ratchet strain has shown to be much larger than predicted based on a usual method of the linear superposition of strains due to creep and plasticity. The result shows there observed the creep-plasticity interaction in the observation. (orig.)

  14. Experimental study on uniaxial ratcheting deformation and failure behavior of 304 stainless steel

    International Nuclear Information System (INIS)

    Yang Xianjie; Gao Qing; Cai Lixun; Liu Yujie

    2004-01-01

    In the paper, the tests of cyclic strain ratcheting and low cycle fatigue for 304 stainless steel under uniaxial cyclic straining were carried out to systematically explore the deformation and failure behavior of the material. The experimental study shows that the cyclic strain ratcheting deformation behavior of the material is different from either the uniaxial monotonic tensile one or the cyclic deformation one under the symmetrical cyclic straining with the same strain amplitude, and the strain ratcheting deformation and failure behaviors depend on both the plastic strain amplitude and the strain increment at the cyclic maximum strain. Some significant results were observed

  15. Ratcheting and low cycle fatigue behavior of SA333 steel and their life prediction

    International Nuclear Information System (INIS)

    Paul, Surajit Kumar; Sivaprasad, S.; Dhar, S.; Tarafder, S.

    2010-01-01

    Ratcheting and low cycle fatigue (LCF) experiments have been conducted at 25 o C temperature in laboratory environment under different loading conditions. SA333 steel exhibits cyclic hardening throughout its life during LCF. It is found that ratcheting strain increases with both increasing mean stress and stress amplitude. It has also been noticed that plastic strain amplitude and plastic strain energy decrease with increase in mean stress at constant stress amplitude. Ratcheting and LCF life in the range of 10 2 -10 5 cycles have been predicted with the help of a mean stress-based fatigue lifing equation.

  16. Effects of kinematic hardening rules on thermal ratchetting analysis of cylinders subjected to cyclically moving temperature distribution

    International Nuclear Information System (INIS)

    Ohno, N.; Kobayashi, M.

    1995-01-01

    In the present work, thermal ratchetting in a cylinder subjected to a cyclically moving temperature front (i.e. liquid surface induced thermal ratchetting) was analyzed by implementing in a finite element method the four kinds of plasticity models with different kinematic hardening rules. The following findings were thus obtained concerning effects of the kinematic hardening rules on the analysis. (1) If transition nonlinear hardening after yielding is disregarded, the thermal ratchetting becomes significant, as seen in the results of the PP and LKH models. Especially the PP model, which does not express any strain hardening, predicts steady development of the thermal ratchetting. (2) If significant mechanical ratchetting is allowed in the modeling of kinematic hardening, the thermal ratchetting becomes marked, as seen in the results of the AF model. (3) Model dependence of the thermal ratchetting is more noticeable when the difference of temperature at the temperature front, ΔT, is smaller. (4) The OW model makes the thermal ratchetting stop at a smaller number of cycles when ΔT is smaller. On the other hand, the LKH and AF models allow that the thermal ratchetting to develop more constantly when ΔT is smaller. As seen from the above findings, the analysis of liquid surface induced thermal ratchetting has great dependence on the kinematic hardening rules employed. Especially the PP model, which has been used often to analyze the thermal ratchetting so far, gives too large development of the thermal ratchetting. Thus we may say that in order to improve the analysis it is necessary to use an appropriate kinematic hardening model which is capable of expressing appropriately both mechanical ratchetting and transient nonlinear hardening after yielding. (author)

  17. Effect of moving distance of temperature distribution on thermal ratchetting behavior of a FBR reactor vessel

    International Nuclear Information System (INIS)

    Ueta, Masahiro; Douzaki, Kouji; Takahashi, Yukio; Ooka, Yuji; Osaki, Toshio; Take, Kouji.

    1992-01-01

    It should be considered in a FBR reactor vessel design that thermal ratchetting might be caused by moving axial thermal gradient, in other words, moving sodium level. The behavior and the mechanism of ratchetting have almost become clear by studies for the past several years. A simplified evaluation method for ratchetting behavior has been proposed. However, the evaluation method has been shown to be excessively conservative by testing results. In this paper, the effect of moving distance of axial temperature distributions, which is one of main factors to be considered in precise estimation of ratchetting behavior, is studied by inelastic analyses. Based on the study, it is proposed to introduce a strain reducing factor taking account of residual stresses in the region of moving axial temperature distribution to the original evaluation method. The new method has been validated by comparing the prediction with results of both testing and the original method. (author)

  18. Firm Innovation and the Ratchet Effect Among Consumer Packaged Goods Firms

    OpenAIRE

    Christine Moorman; Simone Wies; Natalie Mizik; Fredrika J. Spencer

    2012-01-01

    We consider how public firms influence their stock market valuations by timing the introduction of innovative new products. Our focus is on innovation ratchet strategy --firms timing the introduction of innovations in order to demonstrate an improvement in the number of introductions over time. We document that public firms use an innovation ratchet strategy more often than do private firms and that the stock market rewards public firms for doing so. These rewards from the stock market, howev...

  19. A three-bar model for ratcheting of fusion reactor first wall

    International Nuclear Information System (INIS)

    Wolters, J.; Majumdar, S.

    1994-12-01

    First wall structures of fusion reactors are subjected to cyclic bending stresses caused by inhomogeneous temperature distribution during plasma burn cycles and by electromagnetically induced impact loads during plasma disruptions. Such a combination of loading can potentially lead to ratcheting or incremental accumulation of plastic strain with cycles. An elastic-plastic three-bar model is developed to investigate the ratcheting behavior of the first wall

  20. Towards Computing Ratcheting and Training in Superconducting Magnets

    International Nuclear Information System (INIS)

    Ferracin, Paolo; Caspi, Shlomo; Lietzke, A.F.

    2007-01-01

    The Superconducting Magnet Group at Lawrence Berkeley National Laboratory (LBNL) has been developing 3D finite element models to predict the behavior of high field Nb 3 Sn superconducting magnets. The models track the coil response during assembly, cool-down, and excitation, with particular interest on displacements when frictional forces arise. As Lorentz forces were cycled, irreversible displacements were computed and compared with strain gauge measurements. Additional analysis was done on the local frictional energy released during magnet excitation, and the resulting temperature rise. Magnet quenching and training was correlated to the level of energy release during such mechanical displacements under frictional forces. We report in this paper the computational results of the ratcheting process, the impact of friction, and the path-dependent energy release leading to a computed magnet training curve

  1. Micro rectennas: Brownian ratchets for thermal-energy harvesting

    International Nuclear Information System (INIS)

    Pan, Y.; Powell, C. V.; Balocco, C.; Song, A. M.

    2014-01-01

    We experimentally demonstrated the operation of a rectenna for harvesting thermal (blackbody) radiation and converting it into dc electric power. The device integrates an ultrafast rectifier, the self-switching nanodiode, with a wideband log-periodic spiral microantenna. The radiation from the thermal source drives the rectenna out of thermal equilibrium, permitting the rectification of the excess thermal fluctuations from the antenna. The power conversion efficiency increases with the source temperatures up to 0.02% at 973 K. The low efficiency is attributed mainly to the impedance mismatch between antenna and rectifier, and partially to the large field of view of the antenna. Our device not only opens a potential solution for harvesting thermal energy but also provides a platform for experimenting with Brownian ratchets

  2. Micro rectennas: Brownian ratchets for thermal-energy harvesting

    Science.gov (United States)

    Pan, Y.; Powell, C. V.; Song, A. M.; Balocco, C.

    2014-12-01

    We experimentally demonstrated the operation of a rectenna for harvesting thermal (blackbody) radiation and converting it into dc electric power. The device integrates an ultrafast rectifier, the self-switching nanodiode, with a wideband log-periodic spiral microantenna. The radiation from the thermal source drives the rectenna out of thermal equilibrium, permitting the rectification of the excess thermal fluctuations from the antenna. The power conversion efficiency increases with the source temperatures up to 0.02% at 973 K. The low efficiency is attributed mainly to the impedance mismatch between antenna and rectifier, and partially to the large field of view of the antenna. Our device not only opens a potential solution for harvesting thermal energy but also provides a platform for experimenting with Brownian ratchets.

  3. The westward drift of the lithosphere: A tidal ratchet?

    Directory of Open Access Journals (Sweden)

    A. Carcaterra

    2018-03-01

    Full Text Available Is the westerly rotation of the lithosphere an ephemeral accidental recent phenomenon or is it a stable process of Earth's geodynamics? The reason why the tidal drag has been questioned as the mechanism determining the lithospheric shift relative to the underlying mantle is the apparent too high viscosity of the asthenosphere. However, plate boundaries asymmetries are a robust indication of the ‘westerly’ decoupling of the entire Earth's outer lithospheric shell and new studies support lower viscosities in the low-velocity layer (LVZ atop the asthenosphere. Since the solid Earth tide oscillation is longer in one side relative to the other due to the contemporaneous Moon's revolution, we demonstrate that a non-linear rheological behavior is expected in the lithosphere mantle interplay. This may provide a sort of ratchet favoring lowering of the LVZ viscosity under shear, allowing decoupling in the LVZ and triggering the westerly motion of the lithosphere relative to the mantle.

  4. Micro rectennas: Brownian ratchets for thermal-energy harvesting

    Energy Technology Data Exchange (ETDEWEB)

    Pan, Y.; Powell, C. V.; Balocco, C., E-mail: claudio.balocco@durham.ac.uk [School of Engineering and Computing Sciences, Durham University, Durham DH1 3LE (United Kingdom); Song, A. M. [School of Electrical and Electronic Engineering, University of Manchester, Manchester M13 9PL (United Kingdom)

    2014-12-22

    We experimentally demonstrated the operation of a rectenna for harvesting thermal (blackbody) radiation and converting it into dc electric power. The device integrates an ultrafast rectifier, the self-switching nanodiode, with a wideband log-periodic spiral microantenna. The radiation from the thermal source drives the rectenna out of thermal equilibrium, permitting the rectification of the excess thermal fluctuations from the antenna. The power conversion efficiency increases with the source temperatures up to 0.02% at 973 K. The low efficiency is attributed mainly to the impedance mismatch between antenna and rectifier, and partially to the large field of view of the antenna. Our device not only opens a potential solution for harvesting thermal energy but also provides a platform for experimenting with Brownian ratchets.

  5. Magnetic quantum ratchet effect in Si-MOSFETs

    International Nuclear Information System (INIS)

    Ganichev, S D; Karch, J; Kamann, J; Tarasenko, S A; Kvon, Z D

    2014-01-01

    We report on the observation of magnetic quantum ratchet effect in metal-oxide-semiconductor field-effect-transistors on silicon surface (Si-MOSFETs). We show that the excitation of an unbiased transistor by ac electric field of terahertz radiation at normal incidence leads to a direct electric current between the source and drain contacts if the transistor is subjected to an in-plane magnetic field. The current rises linearly with the magnetic field strength and quadratically with the ac electric field amplitude. It depends on the polarization state of the ac field and can be induced by both linearly and circularly polarized radiation. We present the quasi-classical and quantum theories of the observed effect and show that the current originates from the Lorentz force acting upon carriers in asymmetric inversion channels of the transistors. (paper)

  6. Can vocal conditioning trigger a semiotic ratchet in marmosets?

    Directory of Open Access Journals (Sweden)

    Hjalmar Kosmos Turesson

    2015-10-01

    Full Text Available The complexity of human communication has often been taken as evidence that our language reflects a true evolutionary leap, bearing little resemblance to any other animal communication system. The putative uniqueness of the human language poses serious evolutionary and ethological challenges to a rational explanation of human communication. Here we review ethological, anatomical, molecular and computational results across several species to set boundaries for these challenges. Results from animal behavior, cognitive psychology, neurobiology, and semiotics indicate that human language shares multiple features with other primate communication systems, such as specialized brain circuits for sensorimotor processing, the capability for indexical (pointing and symbolic (referential signaling, the importance of shared intentionality for associative learning, affective conditioning and parental scaffolding of vocal production. The most substantial differences lie in the higher human capacity for symbolic compositionality, fast vertical transmission of new symbols across generations, and irreversible accumulation of novel adaptive behaviors (cultural ratchet. We hypothesize that increasingly-complex vocal conditioning of an appropriate animal model may be sufficient to trigger a semiotic ratchet, evidenced by progressive sign complexification, as spontaneous contact calls become indexes, then symbols and finally arguments (strings of symbols. To test this hypothesis, we outline a series of conditioning experiments in the common marmoset (Callithrix jacchus. The experiments are designed to probe the limits of vocal communication in a prosocial, highly vocal primate 35 million years far from the human lineage, so as to shed light on the mechanisms of semiotic complexification and cultural transmission, and serve as a naturalistic behavioral setting for the investigation of language disorders.

  7. Can vocal conditioning trigger a semiotic ratchet in marmosets?

    Science.gov (United States)

    Turesson, Hjalmar K; Ribeiro, Sidarta

    2015-01-01

    The complexity of human communication has often been taken as evidence that our language reflects a true evolutionary leap, bearing little resemblance to any other animal communication system. The putative uniqueness of the human language poses serious evolutionary and ethological challenges to a rational explanation of human communication. Here we review ethological, anatomical, molecular, and computational results across several species to set boundaries for these challenges. Results from animal behavior, cognitive psychology, neurobiology, and semiotics indicate that human language shares multiple features with other primate communication systems, such as specialized brain circuits for sensorimotor processing, the capability for indexical (pointing) and symbolic (referential) signaling, the importance of shared intentionality for associative learning, affective conditioning and parental scaffolding of vocal production. The most substantial differences lie in the higher human capacity for symbolic compositionality, fast vertical transmission of new symbols across generations, and irreversible accumulation of novel adaptive behaviors (cultural ratchet). We hypothesize that increasingly-complex vocal conditioning of an appropriate animal model may be sufficient to trigger a semiotic ratchet, evidenced by progressive sign complexification, as spontaneous contact calls become indexes, then symbols and finally arguments (strings of symbols). To test this hypothesis, we outline a series of conditioning experiments in the common marmoset (Callithrix jacchus). The experiments are designed to probe the limits of vocal communication in a prosocial, highly vocal primate 35 million years far from the human lineage, so as to shed light on the mechanisms of semiotic complexification and cultural transmission, and serve as a naturalistic behavioral setting for the investigation of language disorders.

  8. Phase synchronization for two Brownian motors with bistable coupling on a ratchet

    International Nuclear Information System (INIS)

    Mateos, Jose L.; Alatriste, F.R.

    2010-01-01

    Graphical abstract: We study phase synchronization for a walker with two Brownian motors with bistable coupling on a ratchet and show a connection between synchronization and optimal transport. - Abstract: We study phase synchronization for a walker on a ratchet potential. The walker consist of two particles coupled by a bistable potential that allow the interchange of the order of the particles while moving through a one-dimensional asymmetric periodic ratchet potential. We consider the deterministic and the stochastic dynamics of the center of mass of the walker in a tilted ratchet potential with an external periodic forcing, in the overdamped case. The ratchet potential has to be tilted in order to obtain a rotator or self-sustained nonlinear oscillator in the absence of external periodic forcing. This oscillator has an intrinsic frequency that can be entrained with the frequency of the external driving. We introduced a linear phase through a set of discrete time events and the associated average frequency, and show that this frequency can be synchronized with the frequency of the external driving. In this way, we can properly characterize the phenomenon of synchronization through Arnold tongues and show that the local maxima in the average velocity of the center of mass of the walker, both in the deterministic case and in the presence of noise, correspond to the borders of these Arnold tongues. In this way, we established a connection between optimal transport in ratchets and the phenomenon of phase synchronization.

  9. Collective ratchet effects and reversals for active matter particles on quasi-one-dimensional asymmetric substrates.

    Science.gov (United States)

    McDermott, Danielle; Olson Reichhardt, Cynthia J; Reichhardt, Charles

    2016-10-19

    Using computer simulations, we study a two-dimensional system of sterically interacting self-mobile run-and-tumble disk-shaped particles with an underlying periodic quasi-one-dimensional asymmetric substrate, and show that a rich variety of collective active ratchet behaviors arise as a function of particle density, activity, substrate period, and the maximum force exerted by the substrate. The net dc drift, or ratchet transport flux, is nonmonotonic since it increases with increased activity but is diminished by the onset of self-clustering of the active particles. Increasing the particle density decreases the ratchet transport flux for shallow substrates but increases the ratchet transport flux for deep substrates due to collective hopping events. At the highest particle densities, the ratchet motion is destroyed by a self-jamming effect. We show that it is possible to realize reversals of the direction of the net dc drift in the deep substrate limit when multiple rows of active particles can be confined in each substrate minimum, permitting emergent particle-like excitations to appear that experience an inverted effective substrate potential. We map out a phase diagram of the forward and reverse ratchet effects as a function of the particle density, activity, and substrate properties.

  10. Dielectrophoretic trapping of DNA-coated gold nanoparticles on silicon based vertical nanogap devices.

    Science.gov (United States)

    Strobel, Sebastian; Sperling, Ralph A; Fenk, Bernhard; Parak, Wolfgang J; Tornow, Marc

    2011-06-07

    We report on the successful dielectrophoretic trapping and electrical characterization of DNA-coated gold nanoparticles on vertical nanogap devices (VNDs). The nanogap devices with an electrode distance of 13 nm were fabricated from Silicon-on-Insulator (SOI) material using a combination of anisotropic reactive ion etching (RIE), selective wet chemical etching and metal thin-film deposition. Au nanoparticles (diameter 40 nm) coated with a monolayer of dithiolated 8 base pairs double stranded DNA were dielectrophoretically trapped into the nanogap from electrolyte buffer solution at MHz frequencies as verified by scanning and transmission electron microscopy (SEM/TEM) analysis. First electrical transport measurements through the formed DNA-Au-DNA junctions partially revealed an approximately linear current-voltage characteristic with resistance in the range of 2-4 GΩ when measured in solution. Our findings point to the importance of strong covalent bonding to the electrodes in order to observe DNA conductance, both in solution and in the dry state. We propose our setup for novel applications in biosensing, addressing the direct interaction of biomolecular species with DNA in aqueous electrolyte media.

  11. Brownian Ratchet Mechanism for Faithful Segregation of Low-Copy-Number Plasmids.

    Science.gov (United States)

    Hu, Longhua; Vecchiarelli, Anthony G; Mizuuchi, Kiyoshi; Neuman, Keir C; Liu, Jian

    2017-04-11

    Bacterial plasmids are extrachromosomal DNA that provides selective advantages for bacterial survival. Plasmid partitioning can be remarkably robust. For high-copy-number plasmids, diffusion ensures that both daughter cells inherit plasmids after cell division. In contrast, most low-copy-number plasmids need to be actively partitioned by a conserved tripartite ParA-type system. ParA is an ATPase that binds to chromosomal DNA; ParB is the stimulator of the ParA ATPase and specifically binds to the plasmid at a centromere-like site, parS. ParB stimulation of the ParA ATPase releases ParA from the bacterial chromosome, after which it takes a long time to reset its DNA-binding affinity. We previously demonstrated in vitro that the ParA system can exploit this biochemical asymmetry for directed cargo transport. Multiple ParA-ParB bonds can bridge a parS-coated cargo to a DNA carpet, and they can work collectively as a Brownian ratchet that directs persistent cargo movement with a ParA-depletion zone trailing behind. By extending this model, we suggest that a similar Brownian ratchet mechanism recapitulates the full range of actively segregated plasmid motilities observed in vivo. We demonstrate that plasmid motility is tuned as the replenishment rate of the ParA-depletion zone progressively increases relative to the cargo speed, evolving from diffusion to pole-to-pole oscillation, local excursions, and, finally, immobility. When the plasmid replicates, the daughters largely display motilities similar to that of their mother, except that when the single-focus progenitor is locally excursive, the daughter foci undergo directed segregation. We show that directed segregation maximizes the fidelity of plasmid partition. Given that local excursion and directed segregation are the most commonly observed modes of plasmid motility in vivo, we suggest that the operation of the ParA-type partition system has been shaped by evolution for high fidelity of plasmid segregation

  12. Ratcheting study in pressurized piping components under cyclic loading at room temperature

    International Nuclear Information System (INIS)

    Ravi Kiran, A.; Agrawal, M.K.; Reddy, G.R.; Vaze, K.K.; Ghosh, A.K.; Kushwaha, H.S.

    2006-07-01

    The nuclear power plant piping components and systems are often subjected to reversing cyclic loading conditions due to various process transients, seismic and other events. Earlier the design of piping subjected to seismic excitation was based on the principle of plastic collapse. It is believed that during such events, fatigue-ratcheting is likely mode of failure of piping components. The 1995 ASME Boiler and Pressure Vessel code, Section-III, has incorporated the reverse dynamic loading and ratcheting into the code. Experimental and analytical studies are carried out to understand this failure mechanism. The biaxial ratcheting characteristics of SA 333, Gr. 6 steel and SS 304 stainless steel at room temperature are investigated in the present work. Experiments are carried out on straight pipes subjected to internal pressure and cyclic bending load applied in a three point and four point bend test configurations. A shake table test is also carried out on a pressurized elbow by applying sinusoidal base excitation. Analytical simulation of ratcheting in the piping elements is carried out. Chaboche nonlinear kinematic hardening model is used for ratcheting simulation. (author)

  13. Quasi-static and ratcheting properties of trabecular bone under uniaxial and cyclic compression.

    Science.gov (United States)

    Gao, Li-Lan; Wei, Chao-Lei; Zhang, Chun-Qiu; Gao, Hong; Yang, Nan; Dong, Li-Min

    2017-08-01

    The quasi-static and ratcheting properties of trabecular bone were investigated by experiments and theoretical predictions. The creep tests with different stress levels were completed and it is found that both the creep strain and creep compliance increase rapidly at first and then increase slowly as the creep time goes by. With increase of compressive stress the creep strain increases and the creep compliance decreases. The uniaxial compressive tests show that the applied stress rate makes remarkable influence on the compressive behaviors of trabecular bone. The Young's modulus of trabecular bone increases with increase of stress rate. The stress-strain hysteresis loops of trabecular bone under cyclic load change from sparse to dense with increase of number of cycles, which agrees with the change trend of ratcheting strain. The ratcheting strain rate rapidly decreases at first, and then exhibits a relatively stable and small value after 50cycles. Both the ratcheting strain and ratcheting strain rate increase with increase of stress amplitude or with decrease of stress rate. The creep model and the nonlinear viscoelastic constitutive model of trabecular bone were proposed and used to predict its creep property and rate-dependent compressive property. The results show that there are good agreements between the experimental data and predictions. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Peptide Probes Reveal a Hydrophobic Steric Ratchet in the Anthrax Toxin Protective Antigen Translocase.

    Science.gov (United States)

    Colby, Jennifer M; Krantz, Bryan A

    2015-11-06

    Anthrax toxin is a tripartite virulence factor produced by Bacillus anthracis during infection. Under acidic endosomal pH conditions, the toxin's protective antigen (PA) component forms a transmembrane channel in host cells. The PA channel then translocates its two enzyme components, lethal factor and edema factor, into the host cytosol under the proton motive force. Protein translocation under a proton motive force is catalyzed by a series of nonspecific polypeptide binding sites, called clamps. A 10-residue guest/host peptide model system, KKKKKXXSXX, was used to functionally probe polypeptide-clamp interactions within wild-type PA channels. The guest residues were Thr, Ala, Leu, Phe, Tyr, and Trp. In steady-state translocation experiments, the channel blocked most tightly with peptides that had increasing amounts of nonpolar surface area. Cooperative peptide binding was observed in the Trp-containing peptide sequence but not the other tested sequences. Trp substitutions into a flexible, uncharged linker between the lethal factor amino-terminal domain and diphtheria toxin A chain expedited translocation. Therefore, peptide-clamp sites in translocase channels can sense large steric features (like tryptophan) in peptides, and while these steric interactions may make a peptide translocate poorly, in the context of folded domains, they can make the protein translocate more rapidly presumably via a hydrophobic steric ratchet mechanism. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  15. Quantum ratchets, the orbital Josephson effect, and chaos in Bose-Einstein condensates

    Science.gov (United States)

    Carr, Lincoln D.; Heimsoth, Martin; Creffield, Charles E.; Sols, Fernando

    2014-03-01

    In a system of ac-driven condensed bosons we study a new type of Josephson effect occurring between states sharing the same region of space and the same internal atom structure. We first develop a technique to calculate the long-time dynamics of a driven interacting many-body system. For resonant frequencies, this dynamics can be shown to derive from an effective time-independent Hamiltonian which is expressed in terms of standard creation and annihilation operators. Within the subspace of resonant states, and if the undriven states are plane waves, a locally repulsive interaction between bosons translates into an effective attraction. We apply the method to study the effect of interactions on the coherent ratchet current of an asymmetrically driven boson system. We find a wealth of dynamical regimes which includes Rabi oscillations, self-trapping and chaotic behavior. In the latter case, a full quantum many-body calculation deviates from the mean-field results by predicting large quantum fluctuations of the relative particle number. Moreover, we find that chaos and entanglement, as defined by a variety of widely used and accepted measures, are overlapping but distinct notions. Funded by Spanish MINECO, the Ramon y Cajal program (CEC), the Comunidad de Madrid through Grant Microseres, the Heidelberg Center for Quantum Dynamics, and the NSF.

  16. Discrete numerical investigation of the ratcheting phenomenon in granular materials

    Science.gov (United States)

    Calvetti, Francesco; di Prisco, Claudio

    2010-10-01

    Several relevant geotechnical works, such as railway and road embankments, offshore foundations and vibrating machine foundations, are affected by the progressive accumulation of irreversible settlements. These latter represent the macroscopic evidence of the progressive rearrangement of particles under cycling loading, which is commonly referred to, in the literature, as ratcheting. This phenomenon is well known, but it is quite difficult to describe it by means of an appropriate constitutive model. As a consequence, the evaluation of durability of the aforementioned structures remains an open problem. In this article, the phenomenon will be approached by employing a Distinct Element model capable of describing the evolution of the microstructure induced by cyclic mechanical perturbations. Several analyses are performed in order to stress the influence of both the stress level and loading history on the mechanical response of a numerical model of a sand specimen. The numerical analyses are intended to provide an experimental background for conceiving a simplified macro approach based on generalised plasticity theory. In particular by means of probe test the plastic potential and the hardening parameters will be defined as a function of the current stress state and loading history.

  17. Modified Feynman ratchet with velocity-dependent fluctuations

    Directory of Open Access Journals (Sweden)

    Jack Denur

    2004-03-01

    Full Text Available Abstract: The randomness of Brownian motion at thermodynamic equilibrium can be spontaneously broken by velocity-dependence of fluctuations, i.e., by dependence of values or probability distributions of fluctuating properties on Brownian-motional velocity. Such randomness-breaking can spontaneously obtain via interaction between Brownian-motional Doppler effects --- which manifest the required velocity-dependence --- and system geometrical asymmetry. A non random walk is thereby spontaneously superposed on Brownian motion, resulting in a systematic net drift velocity despite thermodynamic equilibrium. The time evolution of this systematic net drift velocity --- and of velocity probability density, force, and power output --- is derived for a velocity-dependent modification of Feynman's ratchet. We show that said spontaneous randomness-breaking, and consequent systematic net drift velocity, imply: bias from the Maxwellian of the system's velocity probability density, the force that tends to accelerate it, and its power output. Maximization, especially of power output, is discussed. Uncompensated decreases in total entropy, challenging the second law of thermodynamics, are thereby implied.

  18. Analysis of the role of elution buffers on the separation capabilities of dielectrophoretic devices

    Directory of Open Access Journals (Sweden)

    Rossana Di Martino

    2016-03-01

    Full Text Available Field flow fractionation dielectrophoretic (FFF-DEP devices are currently used, among the others, for the separation of tumor cells from healthy blood cells. To this end specific suspension/elution buffers (EBs, with reduced conductivity (with respect to that of the cell cytoplasm are generally used. In this paper we investigate the long-term alterations of the cells and elution buffers. We find that the EB conductivity is critically modified within few minutes after cells suspension. In turn, this modification results in a change the ideal separation frequency of the FFF-DEP device. On the other hand we prove that DEP manipulation is preserved for more than three hours for cells suspended in the considered EBs. Keywords: Dielectrophoresis, Elution buffer, Circulating tumor cells, Cell motility

  19. Dielectrophoretic manipulation of human chromosomes in microfluidic channels: extracting chromosome dielectric properties

    DEFF Research Database (Denmark)

    Clausen, Casper Hyttel; Dimaki, Maria; Buckley, Sonia

    2011-01-01

    An investigation of the dielectric properties of polyamine buffer prepared human chromosomes is presented in this paper. Chromosomes prepared in this buffer are only a few micrometers in size and shaped roughly like spherical discs. Dielectrophoresis was therefore chosen as the method...... of manipulation combined with a custom designed microfluidic system containing the required electrodes for dielectrophoresis experiments. Our results show that although this system is presently not able to distinguish between the different chromosomes, it can provide average data for the dielectric properties...... of human chromosomes in polyamine buffer. These can then be used to optimize system designs for further characterization and even sorting. The experimental data from the dielectrophoretic manipulation were combined with theoretical calculations to extract a range of values for the permittivity...

  20. Iterative Dipole Moment Method for the Dielectrophoretic Particle-Particle Interaction in a DC Electric Field

    Directory of Open Access Journals (Sweden)

    Qing Zhang

    2018-01-01

    Full Text Available Electric force is the most popular technique for bioparticle transportation and manipulation in microfluidic systems. In this paper, the iterative dipole moment (IDM method was used to calculate the dielectrophoretic (DEP forces of particle-particle interactions in a two-dimensional DC electric field, and the Lagrangian method was used to solve the transportation of particles. It was found that the DEP properties and whether the connection line between initial positions of particles perpendicular or parallel to the electric field greatly affect the chain patterns. In addition, the dependence of the DEP particle interaction upon the particle diameters, initial particle positions, and the DEP properties have been studied in detail. The conclusions are advantageous in elelctrokinetic microfluidic systems where it may be desirable to control, manipulate, and assemble bioparticles.

  1. Shaping of Rack Cutter Original Profile for Fine-module Ratchet Teeth Cutting

    Science.gov (United States)

    Sharkov, O. V.; Koryagin, S. I.; Velikanov, N. L.

    2018-05-01

    The design models and the process of shaping the cutting edges of the rack cutter for cutting fine-module ratchet teeth are considered in the article. The use of fine-module ratchet teeth can reduce the noise and impact loads during operation of the freewheel mechanisms. Mathematical dependencies for calculating the coordinates determining the geometric position of the points of the front and back edges of the cutting profile of the rack cutter, the workpiece angle of rotation during cutting the ratchet teeth were obtained. When applying the developed method, the initial data are: the radii of the workpiece circumferences passing through the dedendum of the external and internal cut teeth; gradient angles of the front and back edges of the rail.

  2. A simplified approach for ratcheting analysis in structures with elastic follow-up

    International Nuclear Information System (INIS)

    Berton, M.N.; Cabrillat, M.T.

    1991-01-01

    In the framework of an elastic analysis, the RCC-MR design code uses the concept of the efficiency diagram to assess the behaviour of a structure relatively to ratcheting. This diagram was obtained from a lot of experimental results and allows to cover many reactor situations. However this approach needs to classify stresses between primary and secondary stresses and for a few cases, in particular for structures with significant elastic follow-up, this classification is not obvious. After a recall of elastic follow-up definition and a few considerations on the way to evaluate it, an approach is proposed to take it into account in an elastic analysis verifying the avoidance of ratcheting. An experimental program has been developed to study this interaction between elastic follow-up and ratcheting. The first results are presented together with interpretations with the proposed method. (author)

  3. The effect of creep ratchetting on thin shells

    International Nuclear Information System (INIS)

    Hibbeler, R.C.; Wang, P.Y.

    1975-01-01

    The behavior of thin shells, in particular, cylindrical and spherical shells, which are subjected to a long-time cyclic thermal gradient is discussed. Like many reactor components (shells) which are subjected to start-up and shut-down conditions, provided the temperature is high enough, the shell will exhibit a progressive growth with each cycle of temperature. This phenomena is often referred to as ratchetting and is caused by inelastic strains developed by creep. Although the thermal stress distribution is biaxial it is possible to represent the material behavior using a simple uniaxial-stress model. Assuming thermal stress interaction occurs, the equations which determine the solution of the strain growth and stress per cycle are presented. The flexibility of the analysis provides a means for including the effects of an arbitrary temperature-cycle time and temperature dependence of material properties. A step temperature variation is considered. During each part of the temperature cycle it is necessary to satisfy the equilibrium and compatibility conditions for the model. At any instant, the total strain will depend upon elastic, thermal, and creep strain components in addition to prior inelastic creep strains accumulated during previous temperature cycles. Accounting for all these conditions, the relations describing the behavior of the material can be determined during an arbitrary jth cycle of temperature. In particular, the cases of material properties are considered which are used for reactor components. Where possible, a closed form solution is given for appropriate values of the creep law exponents n and m. For the general case, an algorithm for the computer-solution to the problem is given. Using the general solution, the analysis appears to offer a suitable compromise between accurate behavior description and analytical complexity

  4. Effective Brownian ratchet separation by a combination of molecular filtering and a self-spreading lipid bilayer system.

    Science.gov (United States)

    Motegi, Toshinori; Nabika, Hideki; Fu, Yingqiang; Chen, Lili; Sun, Yinlu; Zhao, Jianwei; Murakoshi, Kei

    2014-07-01

    A new molecular manipulation method in the self-spreading lipid bilayer membrane by combining Brownian ratchet and molecular filtering effects is reported. The newly designed ratchet obstacle was developed to effectively separate dye-lipid molecules. The self-spreading lipid bilayer acted as both a molecular transport system and a manipulation medium. By controlling the size and shape of ratchet obstacles, we achieved a significant increase in the separation angle for dye-lipid molecules compared to that with the previous ratchet obstacle. A clear difference was observed between the experimental results and the simple random walk simulation that takes into consideration only the geometrical effect of the ratchet obstacles. This difference was explained by considering an obstacle-dependent local decrease in molecular diffusivity near the obstacles, known as the molecular filtering effect at nanospace. Our experimental findings open up a novel controlling factor in the Brownian ratchet manipulation that allow the efficient separation of molecules in the lipid bilayer based on the combination of Brownian ratchet and molecular filtering effects.

  5. Quantifying the threat of extinction from Muller's ratchet in the diploid Amazon molly (Poecilia formosa

    Directory of Open Access Journals (Sweden)

    Loewe Laurence

    2008-03-01

    Full Text Available Abstract Background The Amazon molly (Poecilia formosa is a small unisexual fish that has been suspected of being threatened by extinction from the stochastic accumulation of slightly deleterious mutations that is caused by Muller's ratchet in non-recombining populations. However, no detailed quantification of the extent of this threat is available. Results Here we quantify genomic decay in this fish by using a simple model of Muller's ratchet with the most realistic parameter combinations available employing the evolution@home global computing system. We also describe simple extensions of the standard model of Muller's ratchet that allow us to deal with selfing diploids, triploids and mitotic recombination. We show that Muller's ratchet creates a threat of extinction for the Amazon molly for many biologically realistic parameter combinations. In most cases, extinction is expected to occur within a time frame that is less than previous estimates of the age of the species, leading to a genomic decay paradox. Conclusion How then does the Amazon molly survive? Several biological processes could individually or in combination solve this genomic decay paradox, including paternal leakage of undamaged DNA from sexual sister species, compensatory mutations and many others. More research is needed to quantify the contribution of these potential solutions towards the survival of the Amazon molly and other (ancient asexual species.

  6. Prediction of ratcheting behaviour of 304 SS cylindrical shell using the Chaboche model

    International Nuclear Information System (INIS)

    Lee, Hyeong-Yeon; Kim, Jong Bum; Lee, Jae-Han; Yoo, Bong

    1997-01-01

    Ratcheting, that is, a progressive cyclic inelastic deformation can occur in a component subjected to thermal secondary stress, mechanical stress or both in the presence of a primary stress. The circumferential plastic strain may be accumulated with the increase of the number of cycles when a cylinder is subjected to a temperature front moving cyclically in the axial direction. This phenomenon of liquid surface induced thermal ratcheting is important in the design of liquid metal reactor. The ratcheting behaviour of a thin-walled 304 stainless steel cylinder under axially moving temperature distribution was analyzed using the constitutive theory of Chaboche. The constitutive model was implemented as a user subroutine of ABAQUS and it was verified through the comparison with the exact solutions for the uniaxial cyclic loading and test results available in the literature for the cylinder. In addition, ratcheting in pressurized push-pull pipes under loading conditions of ± 1% axial strain with steady hoop stress was analyzed with Chaboche model. It is shown that the elastic-plastic analysis using Chaboche model can evaluate properly the progressive strain accumulation under secondary cyclic loads. (author). 10 refs, 11 figs., 1 tab

  7. Thermally driven ratchet motion of a skyrmion microcrystal and topological magnon Hall effect

    NARCIS (Netherlands)

    Mochizuki, M.; Yu, X.Z.; Seki, S.; Kanazawa, N.; Koshibae, W.; Zang, J.; Mostovoy, M.; Tokura, Y.; Nagaosa, N.

    2014-01-01

    Spontaneously emergent chirality is an issue of fundamental importance across the natural sciences. It has been argued that a unidirectional (chiral) rotation of a mechanical ratchet is forbidden in thermal equilibrium, but becomes possible in systems out of equilibrium. Here we report our finding

  8. Vortex ratchet effect in a niobium film with spacing-graded density

    Czech Academy of Sciences Publication Activity Database

    Wu, T.C.; Horng, L.; Wu, J.C.; Cao, R.; Koláček, Jan; Yang, T.-J.

    2007-01-01

    Roč. 102, č. 3 (2007), 033918/1-033918/4 ISSN 0021-8979 R&D Projects: GA ČR GA202/05/0173 Institutional research plan: CEZ:AV0Z10100521 Keywords : vortex ratchet effect * niobium film Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 2.171, year: 2007

  9. Dielectrophoretic Separation of Live and Dead Monocytes Using 3D Carbon-Electrodes

    Directory of Open Access Journals (Sweden)

    Yagmur Yildizhan

    2017-11-01

    Full Text Available Blood has been the most reliable body fluid commonly used for the diagnosis of diseases. Although there have been promising investigations for the development of novel lab-on-a-chip devices to utilize other body fluids such as urine and sweat samples in diagnosis, their stability remains a problem that limits the reliability and accuracy of readouts. Hence, accurate and quantitative separation and characterization of blood cells are still crucial. The first step in achieving high-resolution characteristics for specific cell subpopulations from the whole blood is the isolation of pure cell populations from a mixture of cell suspensions. Second, live cells need to be purified from dead cells; otherwise, dead cells might introduce biases in the measurements. In addition, the separation and characterization methods being used must preserve the genetic and phenotypic properties of the cells. Among the characterization and separation approaches, dielectrophoresis (DEP is one of the oldest and most efficient label-free quantification methods, which directly purifies and characterizes cells using their intrinsic, physical properties. In this study, we present the dielectrophoretic separation and characterization of live and dead monocytes using 3D carbon-electrodes. Our approach successfully removed the dead monocytes while preserving the viability of the live monocytes. Therefore, when blood analyses and disease diagnosis are performed with enriched, live monocyte populations, this approach will reduce the dead-cell contamination risk and achieve more reliable and accurate test results.

  10. Modeling and characterization of dielectrophoretically structured piezoelectric composites using piezoceramic particle inclusions with high aspect ratios

    Science.gov (United States)

    van den Ende, D. A.; Maier, R. A.; van Neer, P. L. M. J.; van der Zwaag, S.; Randall, C. A.; Groen, W. A.

    2013-01-01

    In this work, the piezoelectric properties at high electric fields of dielectrophoretically aligned PZT—polymer composites containing high aspect ratio particles (such as short fibers) are presented. Polarization and strain as a function of electric field are evaluated. The properties of the composites are compared to those of PZT-polymer composites with equiaxed particles, continuous PZT fiber-polymer composites, and bulk PZT ceramics. From high-field polarization and strain measurements, the effective field dependent permittivity and piezoelectric charge constant in the poling direction are determined for dielectrophoresis structured PZT-polymer composites, continuous PZT fiber-polymer composites, and bulk PZT ceramics. The changes in dielectric properties of the inclusions and the matrix at high fields influence the dielectric and piezoelectric properties of the composites. It is found that the permittivity and piezoelectric charge constants increase towards a maximum at an applied field of around 2.5-5 kV/mm. The electric field at which the maximum occurs depends on the aspect ratio and degree of alignment of the inclusions. Experimental values of d33 at low and high applied fields are compared to a model describing the composites as a continuous polymer matrix containing PZT particles of various aspect ratios arranged into chains. Thickness mode coupling factors were determined from measured impedance data using fitted equivalent circuit model simulations. The relatively high piezoelectric strain constants, voltage constants, and thickness coupling factors indicate that such aligned short fiber composites could be useful as flexible large area transducers.

  11. Escherichia coli Fiber Sensors Using Concentrated Dielectrophoretic Force with Optical Defocusing Method.

    Science.gov (United States)

    Tai, Yi-Hsin; Lee, Chia-Wei; Chang, Dao-Ming; Lai, Yu-Sheng; Huang, Ding-Wei; Wei, Pei-Kuen

    2018-05-25

    A sensitive tapered optical fiber tip combined with dielectrophoretic (DEP) trapping was used for rapid and label-free detection of bacteria in water. The angular spectrum of the optical field at the fiber tip was changed with the surrounding refractive index (RI). By measuring far-field intensity change at the defocus plane, the intensity sensitivity was up to 95 200%/RIU (RI unit), and the detection limit was 5.2 × 10 -6 RIU at 0.5% intensity stability. By applying an AC voltage to a Ti/Al coated fiber tip and an indium-tin-oxide glass, the DEP force effectively trapped the Escherichia coli ( E. coli) near the fiber tip. Those bacteria can be directly measured from optical intensity change due to the increase of surrounding RI. By immobilizing the antibody on the Ti/Al fiber tip, the tests for specific K12 bacteria and nonspecific BL21 bacteria verified the specificity. The antibody-immobilized Ti/Al coated fiber tip with DEP trapping can detect bacteria at a concentration about 100 CFU/mL.

  12. A review of microfabrication techniques and dielectrophoretic microdevices for particle manipulation and separation

    International Nuclear Information System (INIS)

    Li, M; Li, W H; Zhang, J; Alici, G; Wen, W

    2014-01-01

    The development of lab-on-a-chip (LOC) devices over the past decade has attracted growing interest. LOC devices aim to achieve the miniaturization, integration, automation and parallelization of biological and chemical assays. One of the applications, the ability to effectively and accurately manipulate and separate micro- and nano-scale particles in an aqueous solution, is particularly appealing in biological, chemical and medical fields. Among the technologies that have been developed and implemented in microfluidic microsystems for particle manipulation and separation (such as mechanical, inertial, hydrodynamic, acoustic, optical, magnetic and electrical methodologies), dielectrophoresis (DEP) may prove to be the most popular because of its label-free nature, ability to manipulate neutral bioparticles, analyse with high selectivity and sensitivity, compatibility with LOC devices, and easy and direct interface with electronics. The required spatial electric non-uniformities for the DEP effect can be generated by patterning microelectrode arrays within microchannels, or placing insulating obstacles within a microchannel and curving the microchannels. A wide variety of electrode- and insulator-based DEP microdevices have been developed, fabricated, and successfully employed to manipulate and separate bioparticles (i.e. DNA, proteins, bacteria, viruses, mammalian and yeast cells). This review provides an overview of the state-of-the-art of microfabrication techniques and of the structures of dielectrophoretic microdevices aimed towards different applications. The techniques used for particle manipulation and separation based on microfluidics are provided in this paper. In addition, we also present the theoretical background of DEP. (topical review)

  13. "Artificial micro organs"--a microfluidic device for dielectrophoretic assembly of liver sinusoids.

    Science.gov (United States)

    Schütte, Julia; Hagmeyer, Britta; Holzner, Felix; Kubon, Massimo; Werner, Simon; Freudigmann, Christian; Benz, Karin; Böttger, Jan; Gebhardt, Rolf; Becker, Holger; Stelzle, Martin

    2011-06-01

    In order to study possible toxic side effects of potential drug compounds in vitro a reliable test system is needed. Predicting liver toxicity presents a major challenge of particular importance as liver cells grown in a cell culture suffer from a rapid loss of their liver specific functions. Therefore we are developing a new microfluidic test system for liver toxicity. This test system is based on an organ-like liver 3D co-culture of hepatocytes and endothelial cells. We devised a microfluidic chip featuring cell culture chambers with integrated electrodes for the assembly of liver sinusoids by dielectrophoresis. Fluid channels enable an organ-like perfusion with culture media and test compounds. Different chamber designs were studied and optimized with regard to dielectrophoretic force distribution, hydrodynamic flow profile, and cell trapping rate using numeric simulations. Based on simulation results a microchip was injection-moulded from COP. This chip allowed the assembly of viable hepatocytes and endothelial cells in a sinusoid-like fashion.

  14. Off-Axis Ratcheting Behavior of Unidirectional Carbon/Epoxy Laminate under Asymmetric Cyclic Loading at High Temperature

    Science.gov (United States)

    2011-11-01

    ply unidirectional carbon/epoxy laminates [0]12 were fabricated from the prepreg tape of P3252-20 (TORAY). They were laid up by hand and cured in...Off-Axis Ratcheting Behavior of Unidirectional Carbon/Epoxy Laminate under Asymmetric Cyclic Loading at High Temperature Takafumi Suzuki 1 and...Development of an engineering model for predicting the off-axis ratcheting behavior of a unidirectional CFRP laminate has been attempted. For this purpose

  15. Incremental elongation or ratchetting - Experimental tests and practical method of analysis (on stainless steel 304L and 306L)

    International Nuclear Information System (INIS)

    Cousseran, Pierre; Lebey, Jacques; Roche, Roland; Clement, Gerard; Moulin, Didier.

    1980-12-01

    Ratchetting, or incremental elongation can be considered as a creep enhancement when cyclic deformations are added to a primary constant load. Under examination, it appears that theoretical models proposed till now do not fit correctly the actual behavior of materials. From experimental tests results performed in Saclay, a simplified method for prevention of ratcheting is proposed. A validation was made by using experimental data from various sources [fr

  16. The Bree problem with different yield stresses on-load and off-load and application to creep ratcheting

    International Nuclear Information System (INIS)

    Bradford, R.A.W.; Ure, J.; Chen, H.F.

    2014-01-01

    The ratchet boundaries and ratchet strains are derived for the Bree problem and an elastic-perfectly plastic material with different yield stresses on-load and off-load. The Bree problem consists of a constant uniaxial primary membrane stress and a cycling thermal bending stress. The ratchet problem with differing yield stresses is also solved for a modified loading in which both the primary membrane and thermal bending stresses cycle in-phase. The analytic solutions for the ratchet boundaries are compared with the results of deploying the linear matching method (LMM) and excellent agreement is found. Whilst these results are of potential utility for purely elastic–plastic behaviour, since yield stresses will often differ at the two ends of the cycle, the solution is also proposed as a means of assessing creep ratcheting via a creep ductility exhaustion approach. -- Highlights: • The Bree problem is solved for differing yield stresses on and off load. • The modified Bree problem with cycling primary load is also solved. • These solutions can be applied to creep ratcheting using a pseudo-yield stress

  17. A new approach to quantify the additional effect of primary overloads on ratcheting

    International Nuclear Information System (INIS)

    Waeckel, N.; Faure, O.; Sperandio, M.; Cousin, M.; Taleb, L.

    1991-01-01

    Taking into account the temporary nature of overloads reduces the conservatism of the current RCC-MR rules for prevention of ratcheting. An empirical K factor determined by the BITUBE tests carried out at INSA LYON, permits to quantify the influence of short-term mechanical overloads by comparison with the case without overload. The prediction of ratcheting risks by the RCC-MR efficiency diagram using a fictitious increased primary load by a K-factor is more fitted to the design of structures submitted to seisms. From then on, taking advantage of the workability of the experimental device BITUBE a new tests program has begun to confirm the results expressed above. (author)

  18. Cooperation and competition between two symmetry breakings in a coupled ratchet

    Science.gov (United States)

    Li, Chen-Pu; Chen, Hong-Bin; Fan, Hong; Xie, Ge-Ying; Zheng, Zhi-Gang

    2018-03-01

    We investigate the collective mechanism of coupled Brownian motors in a flashing ratchet in the presence of coupling symmetry breaking and space symmetry breaking. The dependences of directed current on various parameters are extensively studied in terms of numerical simulations and theoretical analysis. Reversed motion can be achieved by modulating multiple parameters including the spatial asymmetry coefficient, the coupling asymmetry coefficient, the coupling free length and the coupling strength. The dynamical mechanism of these transport properties can be reasonably explained by the effective potential theory and the cooperation or competition between two symmetry breakings. Moreover, adjusting the Gaussian white noise intensity, which can induce weak reversed motion under certain condition, can optimize and manipulate the directed transport of the ratchet system.

  19. Collective coordinates theory for discrete soliton ratchets in the sine-Gordon model

    Science.gov (United States)

    Sánchez-Rey, Bernardo; Quintero, Niurka R.; Cuevas-Maraver, Jesús; Alejo, Miguel A.

    2014-10-01

    A collective coordinate theory is developed for soliton ratchets in the damped discrete sine-Gordon model driven by a biharmonic force. An ansatz with two collective coordinates, namely the center and the width of the soliton, is assumed as an approximated solution of the discrete nonlinear equation. The dynamical equations of these two collective coordinates, obtained by means of the generalized travelling wave method, explain the mechanism underlying the soliton ratchet and capture qualitatively all the main features of this phenomenon. The numerical simulation of these equations accounts for the existence of a nonzero depinning threshold, the nonsinusoidal behavior of the average velocity as a function of the relative phase between the harmonics of the driver, the nonmonotonic dependence of the average velocity on the damping, and the existence of nontransporting regimes beyond the depinning threshold. In particular, it provides a good description of the intriguing and complex pattern of subspaces corresponding to different dynamical regimes in parameter space.

  20. Hydrodynamic interactions induce movement against an external load in a ratchet dimer Brownian motor.

    Science.gov (United States)

    Fornés, José A

    2010-01-15

    We use the Brownian dynamics with hydrodynamic interactions simulation in order to describe the movement of a elastically coupled dimer Brownian motor in a ratchet potential. The only external forces considered in our system were the load, the random thermal noise and an unbiased thermal fluctuation. For a given set of parameters we observe direct movement against the load force if hydrodynamic interactions were considered.

  1. Ratchetting and creep-fatigue evaluation for nozzle-to-cylinder intersection

    International Nuclear Information System (INIS)

    Barsoum, R.S.; Loomis, R.W.; Stewart, B.D.

    1976-01-01

    The study is part of an analytical investigation on the applicability of the simplified ratchetting and creep-fatigue rules to LMFBR component geometry. Both the detailed inelastic rules and the simplified elastic rules are applied to the results obtained from a three-dimensional finite element analysis of the nozzle-to-cylinder intersection. The results of both evaluations are compared at several locations on the surface, and an assessment of the degree of conservatism of the simplified methods is discussed

  2. Numerical convergence in simulations of multiaxial ratcheting with directional distortional hardening

    Czech Academy of Sciences Publication Activity Database

    Welling, CH.A.; Marek, René; Feigenbaum, H. P.; Dafalias, Y.F.; Plešek, Jiří; Hrubý, Zbyněk; Parma, Slavomír

    2017-01-01

    Roč. 126, November (2017), s. 105-121 ISSN 0020-7683 R&D Projects: GA MŠk(CZ) EF15_003/0000493; GA MŠk LH14018 Keywords : plastic ity * yield * ratcheting * yield surface distortion * directional distortional hardening Subject RIV: JG - Metallurgy OBOR OECD: Materials engineering Impact factor: 2.760, year: 2016 http://www.sciencedirect.com/science/article/pii/S0020768317303499

  3. Experimental study on uniaxial cyclic ratcheting behavior of 304 stainless steel at room temperature

    International Nuclear Information System (INIS)

    Yang Xianjie; Gao Qing; Cai Lixun; Liu Yujie

    2004-01-01

    The cyclic tests for 304 stainless steel with solution heat treatment under uni-axial cyclic straining and stressing were carried out systematically. The effects of the cyclic engineering stress amplitude history with constant mean stress, the mean engineering stress history with constant cyclic stress amplitude and the stress amplitude histories with the specific mean stress increment per cycle on the uni-axial ratcheting deformation behavior were investigated. Some significant results are obtained

  4. Simulation of ratcheting in straight pipes using ANSYS with an improved cyclic plasticity model

    International Nuclear Information System (INIS)

    Hassan, T.; Zhu, Y.; Matzen, V.C.

    1996-01-01

    Ratcheting has been shown to be a contributing cause of failure in several seismic experiments on piping components and systems. Most commercial finite element codes have been unable to simulate the ratcheting in those tests accurately. The reason for this can be traced to inadequate plasticity constitutive models in the analysis codes. The authors have incorporated an improved cyclic plasticity model, based on an Armstrong-Frederick kinematic hardening rule in conjunction with the Drucker-Palgen plastic modulus equation, into an ANSYS user subroutine. This modified analysis code has been able to simulate quite accurately the ratcheting behavior of a tube subjected to a constant internal pressure and axially strain controlled cycling. This paper describes simulations obtained form this modified ANSYS code for two additional tests: (1) a tube subjected to constant axial stress and prescribed torsional cycling, and (2) a straight pipe subjected to constant internal pressure and quasi-static cyclic bending. The analysis results from the modified ANSYS code are compared to the experimental data, as well as results from ABAQUS and the original ANSYS code. The resulting correlation shows a significant improvement over the original ANSYS and the ABAQUS codes

  5. Pinning, flux diodes and ratchets for vortices interacting with conformal pinning arrays

    International Nuclear Information System (INIS)

    Olson Reichhardt, C. J.; Wang, Y. L.; Argonne National Laboratory; Xiao, Z. L.; Northern Illinois University, DeKalb, IL

    2016-01-01

    A conformal pinning array can be created by conformally transforming a uniform triangular pinning lattice to produce a new structure in which the six-fold ordering of the original lattice is conserved but where there is a spatial gradient in the density of pinning sites. Here we examine several aspects of vortices interacting with conformal pinning arrays and how they can be used to create a flux flow diode effect for driving vortices in different directions across the arrays. Under the application of an ac drive, a pronounced vortex ratchet effect occurs where the vortices flow in the easy direction of the array asymmetry. When the ac drive is applied perpendicular to the asymmetry direction of the array, it is possible to realize a transverse vortex ratchet effect where there is a generation of a dc flow of vortices perpendicular to the ac drive due to the creation of a noise correlation ratchet by the plastic motion of the vortices. We also examine vortex transport in experiments and compare the pinning effectiveness of conformal arrays to uniform triangular pinning arrays. In conclusion, we find that a triangular array generally pins the vortices more effectively at the first matching field and below, while the conformal array is more effective at higher fields where interstitial vortex flow occurs.

  6. A three dimensional elastoplastic cyclic constitutive law with a semi discrete variable and a ratchetting stress

    International Nuclear Information System (INIS)

    Geyer, P.; Proix, J.M.; Jayet-Gendrot, S.; Schoenberger, P.; Taheri, S.

    1995-01-01

    The study of cyclic elastoplastic constitutive law is, at the moment, focused on non proportional loadings, but for uniaxial loadings some problems remain, as for example the ability for a law to describe simultaneously ratcheting (constant increment of strain) in non symmetrical ones. We propose a law with a discrete memory variable, the plastic strain at the last unloading, and a ratchetting stress which, in addition to previous phenomena, describes the other hand the choice of all macroscopic variables is justified by a microscopic analysis. The extension to 3D situations of this law is proposed. The discrete nature of the memory leads to discontinuity problems for some loading paths, a modification is then proposed which uses a differential evolution law. For large enough uniaxial cycles, the uniaxial law is nevertheless recovered. An incremental form of he implicit evolution problem is given, and we describe the implementation of this model in the Code Aster a thermomechanical structural software using the f.e.m. developed at Electricite de France. For a 316 stainless steel we present comparisons between experiments and numerical results in uniaxial and biaxial ratchetting and non proportional strain controlled test (circular, square, stair loading). (authors). 13 refs., 10 figs

  7. Analysis of thermal ratchetting of a cylinder subjected to axially moving temperature front. Effect of kinematic hardening rule

    International Nuclear Information System (INIS)

    Ohno, Nobutada; Yari, Takashi; Kobayashi, Mineo

    1995-01-01

    When a cylinder is subjected to a temperature front moving cyclically in the axial direction, the circumferential plastic strain may accumulate with the increase of the number of cycles. This is a thermal ratchetting problem induced by a liquid surface moving in a cylinder, and it is important especially in designing fast breeder reactors. In the present paper, the effect of kinematic hardening rule on the thermal ratchetting analysis is discussed by implementing the following four kinds of kinematic hardening rules in a finite element analysis; the perfectly plastic model (PP), the linear kinematic hardening rule (LKH), the classical nonlinear kinematic hardening rule of Armstrong and Frederick (AF), and the rule proposed recently by Ohno and Wang (OW). It is shown that disregard of transient hardening after yielding leads to overestimating the thermal ratchetting, that a rule predicting larger mechanical ratchetting under uniaxial cyclic loading makes the thermal ratchetting more serious, and that the Ohno and Wang rule can render the analysis most realistic among them. (author)

  8. Ratchetting behavior of primary heat transport (PHT) piping material SA-333 carbon steel subjected to cyclic loads at room temperature

    International Nuclear Information System (INIS)

    Kulkarni, S.; Desai, Y.M.; Kant, T.; Reddy, G.R.; Gupta, C.; Chakravarthy, J.K.

    2004-01-01

    Ratchetting behavior of SA-333 Gr. 6 carbon steel used as primary heat transport (PHT) piping material has been investigated with three constitutive models proposed by Armstrong-Frederick, Chaboche and Ohno-Wang involving different hardening rules. Performance of the above mentioned models have been evaluated for a broad set of uniaxial and biaxial loading histories. The uniaxial ratchetting simulations have been performed for a range of stress ratios (R) by imposing different stress amplitudes and mean stress conditions. Numerical simulations indicated significant ratchetting and opening of hysteresis loop for negative stress ratio with constant mean stress. Application of cyclic stress without mean stress (R = -1.0) has been observed to produce negligible ratchet-strain accumulation in the material. Simulation under the biaxial stress condition was based on modeling of an internally pressurized thin walled pipe subjected to cyclic bending load. Numerical results have been validated with the experiments as per simulation conditions. All three models have been found to predict the observed accumulation of circumferential strain with increasing number of cycles. However, the Armstrong Frederick (A-F) model was found to be inadequate in simulating the ratchetting response for both uniaxial as well as biaxial loading cases. The A-F model actually over-predicted the ratchetting strain in comparison with the experimental strain values. On the other hand, results obtained with the Chaboche and the Ohno-Wang models for both the uniaxial as well as biaxial loading histories have been observed to closely simulate the experimental results. The Ohno-Wang model resulted in better simulation for the presents sets of experimental results in comparison with the Chaboche model. It can be concluded that the Ohno-Wang model suited well compared to the Chaboche model for above sets of uniaxial and biaxial loading histories. (authors)

  9. Many-Body Quantum Chaos and Entanglement in a Quantum Ratchet

    Science.gov (United States)

    Valdez, Marc Andrew; Shchedrin, Gavriil; Heimsoth, Martin; Creffield, Charles E.; Sols, Fernando; Carr, Lincoln D.

    2018-06-01

    We uncover signatures of quantum chaos in the many-body dynamics of a Bose-Einstein condensate-based quantum ratchet in a toroidal trap. We propose measures including entanglement, condensate depletion, and spreading over a fixed basis in many-body Hilbert space, which quantitatively identify the region in which quantum chaotic many-body dynamics occurs, where random matrix theory is limited or inaccessible. With these tools, we show that many-body quantum chaos is neither highly entangled nor delocalized in the Hilbert space, contrary to conventionally expected signatures of quantum chaos.

  10. Electric field and dielectrophoretic force on a dielectric particle chain in a parallel-plate electrode system

    International Nuclear Information System (INIS)

    Techaumnat, B; Eua-arporn, B; Takuma, T

    2004-01-01

    This paper presents results of calculations of the electric field and dielectrophoretic force on a dielectric particle chain suspended in a host liquid lying between parallel-plate electrodes. The method of calculation is based on the method of multipole images using the multipole re-expansion technique. We have investigated the effect of the particle permittivity, the tilt angle (between the chain and the applied field) and the chain arrangement on the electric field and force. The results show that the electric field intensification rises in accordance with the increase in the ratio of the particle-to-liquid permittivity, Γ ε . The electric field at the contact point between the particles decreases with increasing tilt angle, while the maximal field at the contact point between the particles and the plate electrodes is almost unchanged. The maximal field can be approximated by a simple formula, which is a quadratic function of Γ ε . The dielectrophoretic force depends significantly on the distance from other particles or an electrode. However, for the tilt angles in this paper, the horizontal force on the upper particle of the chain always has the direction opposite to the shear direction. The maximal horizontal force of a chain varies proportional to (Γ ε - 1) 1.7 if the particles in the chain are still in contact with each other. The approximated force, based on the force on an isolated chain, has been compared with our calculation results. The comparison shows that no approximation model agrees well with our results throughout the range of permittivity ratios

  11. Controlling heat transport and flow structures in thermal turbulence using ratchet surfaces

    Science.gov (United States)

    Sun, Chao; Jiang, Hechuan; Zhu, Xiaojue; Mathai, Varghese; Verzicco, Roberto; Lohse, Detlef

    2017-11-01

    In this combined experimental and numerical study on thermally driven turbulence in a rectangular cell, the global heat transport and the coherent flow structures are controlled with an asymmetric ratchet-like roughness on the top and bottom plates. We show that, by means of symmetry breaking due to the presence of the ratchet structures on the conducting plates, the orientation of the Large Scale Circulation Roll (LSCR) can be locked to a preferred direction even when the cell is perfectly leveled out. By introducing a small tilt to the system, we show that the LSCR orientation can be tuned and controlled. The two different orientations of LSCR give two quite different heat transport efficiencies, indicating that heat transport is sensitive to the LSCR direction over the asymmetric roughness structure. Through analysis of the dynamics of thermal plume emissions and the orientation of the LSCR over the asymmetric structure, we provide a physical explanation for these findings. This work is financially supported by the Natural Science Foundation of China under Grant No. 11672156, the Dutch Foundation for Fundamental Research on Matter (FOM), the Dutch Technology Foundation (STW) and a VIDI Grant.

  12. CERN Library | Roy Calne presents: "The Ratchet of Science - Curiosity killed the cat" | 26 October

    CERN Multimedia

    CERN Library

    2015-01-01

    Sir Roy Calne will discuss his most recent book: “The Ratchet of Science - Curiosity killed the cat. Can human nature cope with the rapid and accelerated advances of science?”   Monday, 26 October - 4.30 p.m. CERN Filtration plant, Room 222-R-001 There is a limited number of seats. Please register here. The book’s premise is that huge scientific advances throughout history occur in spurts or “ratchets”. It reflects on the good and the evil consequences of discoveries. Due to the worrying nature of human beings, each ratchet in our knowledge is too often accompanied by dangerous applications. Knowledge, once established by a reliable scientific method, cannot be unlearned. The cat is out of the bag and the curiosity may kill the cat – so to speak. Professor Roy Calne illustrates this with the example of the young physicist known to all at CERN: Lise Meitner, who discovered and named nucle...

  13. Ratchet Effects, Negative Mobility, and Phase Locking for Skyrmions on Periodic Substrates

    Science.gov (United States)

    Reichhardt, Charles; Ray, Dipanjan; Olson Reichhardt, Cynthia

    We examine the dynamics of skyrmions interacting with 1D and 2D periodic substrates in the presence of dc and ac drives. We find that the Magnus term strongly affects the skyrmion dynamics and that new kinds of phenomena can occur which are absent for overdamped ac and dc driven particles interacting with similar substrates. We show that it is possible to realize a Magnus induced ratchet for skyrmions interacting with an asymmetric potential, where the application of an ac drive can produce quantized dc motion of the skyrmions even when the ac force is perpendicular to the substrate asymmetry direction. For symmetric substrates it is also possible to achieve a negative mobility effect where the net skyrmion motion runs counter to an applied dc drive. Here, as a function of increasing dc drive, the velocity-force curves show a series of locking phases that have different features from the classic Shapiro steps found in overdamped systems. In the phase locking and ratcheting states, the skyrmions undergo intricate 2D orbits induced by the Magnus term.

  14. Clonal interference and Muller's ratchet in spatial habitats

    International Nuclear Information System (INIS)

    Otwinowski, Jakub; Krug, Joachim

    2014-01-01

    Competition between independently arising beneficial mutations is enhanced in spatial populations due to the linear rather than exponential growth of clones. Recent theoretical studies have pointed out that the resulting fitness dynamics is analogous to a surface growth process, where new layers nucleate and spread stochastically, leading to the build up of scale-invariant roughness. This scenario differs qualitatively from the standard view of adaptation in that the speed of adaptation becomes independent of population size while the fitness variance does not. Here we exploit recent progress in the understanding of surface growth processes to obtain precise predictions for the universal, non-Gaussian shape of the fitness distribution for one-dimensional habitats, which are verified by simulations. When the mutations are deleterious rather than beneficial the problem becomes a spatial version of Muller's ratchet. In contrast to the case of well-mixed populations, the rate of fitness decline remains finite even in the limit of an infinite habitat, provided the ratio U d /s 2 between the deleterious mutation rate and the square of the (negative) selection coefficient is sufficiently large. Using, again, an analogy to surface growth models we show that the transition between the stationary and the moving state of the ratchet is governed by directed percolation. (paper)

  15. Quantitative Magnetic Separation of Particles and Cells Using Gradient Magnetic Ratcheting.

    Science.gov (United States)

    Murray, Coleman; Pao, Edward; Tseng, Peter; Aftab, Shayan; Kulkarni, Rajan; Rettig, Matthew; Di Carlo, Dino

    2016-04-13

    Extraction of rare target cells from biosamples is enabling for life science research. Traditional rare cell separation techniques, such as magnetic activated cell sorting, are robust but perform coarse, qualitative separations based on surface antigen expression. A quantitative magnetic separation technology is reported using high-force magnetic ratcheting over arrays of magnetically soft micropillars with gradient spacing, and the system is used to separate and concentrate magnetic beads based on iron oxide content (IOC) and cells based on surface expression. The system consists of a microchip of permalloy micropillar arrays with increasing lateral pitch and a mechatronic device to generate a cycling magnetic field. Particles with higher IOC separate and equilibrate along the miropillar array at larger pitches. A semi-analytical model is developed that predicts behavior for particles and cells. Using the system, LNCaP cells are separated based on the bound quantity of 1 μm anti-epithelial cell adhesion molecule (EpCAM) particles as a metric for expression. The ratcheting cytometry system is able to resolve a ±13 bound particle differential, successfully distinguishing LNCaP from PC3 populations based on EpCAM expression, correlating with flow cytometry analysis. As a proof-of-concept, EpCAM-labeled cells from patient blood are isolated with 74% purity, demonstrating potential toward a quantitative magnetic separation instrument. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Ratcheting Strain and Microstructure Evolution of AZ31B Magnesium Alloy under a Tensile-Tensile Cyclic Loading.

    Science.gov (United States)

    Yan, Zhifeng; Wang, Denghui; Wang, Wenxian; Zhou, Jun; He, Xiuli; Dong, Peng; Zhang, Hongxia; Sun, Liyong

    2018-03-28

    In this paper, studies were conducted to investigate the deformation behavior and microstructure change in a hot-rolled AZ31B magnesium alloy during a tensile-tensile cyclic loading. The relationship between ratcheting effect and microstructure change was discussed. The ratcheting effect in the material during current tensile-tensile fatigue loading exceeds the material's fatigue limit and the development of ratcheting strain in the material experienced three stages: initial sharp increase stage (Stage I); steady stage (Stage II); and final abrupt increase stage (Stage III). Microstructure changes in Stage I and Stage II are mainly caused by activation of basal slip system. The Extra Geometrically Necessary Dislocations (GNDs) were also calculated to discuss the relationship between the dislocation caused by the basal slip system and the ratcheting strain during the cyclic loading. In Stage III, both the basal slip and the {11-20} twins are found active during the crack propagation. The fatigue crack initiation in the AZ31B magnesium alloy is found due to the basal slip and the {11-20} tensile twins.

  17. Double-temperature ratchet model and current reversal of coupled Brownian motors

    Science.gov (United States)

    Li, Chen-Pu; Chen, Hong-Bin; Zheng, Zhi-Gang

    2017-12-01

    On the basis of the transport features and experimental phenomena observed in studies of molecular motors, we propose a double-temperature ratchet model of coupled motors to reveal the dynamical mechanism of cooperative transport of motors with two heads, where the interactions and asynchrony between two motor heads are taken into account. We investigate the collective unidirectional transport of coupled system and find that the direction of motion can be reversed under certain conditions. Reverse motion can be achieved by modulating the coupling strength, coupling free length, and asymmetric coefficient of the periodic potential, which is understood in terms of the effective potential theory. The dependence of the directed current on various parameters is studied systematically. Directed transport of coupled Brownian motors can be manipulated and optimized by adjusting the pulsation period or the phase shift of the pulsation temperature.

  18. Shaping Cutter Original Profile for Fine-module Ratchet Teeth Cutting

    Science.gov (United States)

    Sharkov, O. V.; Koryagin, S. I.; Velikanov, N. L.

    2018-03-01

    The methods for determining geometric characteristics of a theoretical original profile of the cutter for cutting ratchet teeth with a module of 0.3–1.0 mm are considered in the article. Design models describing the shaping process of cutting edges of cutter teeth are developed. Systems of expressions for determining coordinates of the points of front and back edges of cutter teeth; the workpiece angles of rotation during the cutting process; the minimum cutter radius are received. The basic data when using the proposed technique are: radii of circumferences passing through cavities of cutter teeth and external cut teeth; the gradient angle and length of straight section of the front edge of a cut tooth; angles of rotation of the cutter and the workpiece at the moment of shaping.

  19. Quantum ratchets for periodically kicked cold atoms and Bose-Einstein condensates

    Energy Technology Data Exchange (ETDEWEB)

    Casati, Giulio [Center for Nonlinear and Complex Systems, Universita degli Studi dell' Insubria and Istituto Nazionale per la Fisica della Materia, Unita di Como, Via Valleggio 11, 22100 Como (Italy); Poletti, Dario [Center for Nonlinear and Complex Systems, Universita degli Studi dell' Insubria and Istituto Nazionale per la Fisica della Materia, Unita di Como, Via Valleggio 11, 22100 Como (Italy)

    2007-05-15

    We study cold atoms and Bose-Einstein condensates exposed to time-dependent standing waves of light. We first discuss a quantum chaotic dissipative ratchet using the method of quantum trajectories. This system is characterized by directed transport emerging from a quantum strange attractor. We then present a very simple model of directed transport with cold atoms in a pair of periodically flashed optical lattices. Finally we study the dynamics of a dilute Bose-Einstein condensate confined in a toroidal trap and exposed to a pair of periodically flashed optical lattices. We show that the many-body atom-atom interactions, treated within the mean-field approximation, can generate directed transport.

  20. Experimental tests on ratchet of 304 austenitic steel, at room temperature

    International Nuclear Information System (INIS)

    Boulais, Jacques; Brouard, Daniel; Lebey, Jacques; Roche, Roland.

    1978-09-01

    Most of the studies on ratcheting are theoretical and use very rough constitutive equations for the material behavior (perfect plasticity for instance). Most of the available experimental results concern tests on complex structures, and are difficult to interpret. So there is a need for experimental tests on basic structures easy to use to determine the material characteristics. Tests on thin tubular specimen are very interesting because stress, strain and temperature fields are uniform. The primary stress P is an axial tensile one (dead weight), the secondary stress, with ΔQ range, is due to a cyclic angle controled twist. The incremental elongation is obtained as a function of the number of cycles N for different values of P and ΔQ. Diagrams representing the isocurves of cumulated elongation (for a given number of cycles) as a function of P and ΔQ are shown [fr

  1. Zeeman ratchets: pure spin current generation in mesoscopic conductors with non-uniform magnetic fields

    International Nuclear Information System (INIS)

    Scheid, Matthias; Bercioux, Dario; Richter, Klaus

    2007-01-01

    We consider the possibility to employ a quantum wire realized in a two-dimensional electron gas (2DEG) as a spin ratchet. We show that a net spin current without accompanying net charge transport can be induced in the nonlinear regime by an unbiased external driving via an ac voltage applied between the contacts at the ends of the quantum wire. To achieve this, we make use of the coupling of the electron spin to inhomogeneous magnetic fields created by ferromagnetic stripes patterned on the semiconductor heterostructure that harbors the 2DEG. Using recursive Green function techniques, we numerically study two different set-ups, consisting of one and two ferromagnetic stripes, respectively

  2. Comparisons of ratchetting analysis methods using RCC-M, RCC-MR and ASME codes

    International Nuclear Information System (INIS)

    Yang Yu; Cabrillat, M.T.

    2005-01-01

    The present paper compares the simplified ratcheting analysis methods used in RCC-M, RCC-MR and ASME with some examples. Firstly, comparisons of the methods in RCC-M and efficiency diagram in RCC-MR are investigated. A special method is used to describe these two methods with curves in one coordinate, and the different conservation is demonstrated. RCC-M method is also be interpreted by SR (second ratio) and v (efficiency index) which is used in RCC-MR. Hence, we can easily compare the previous two methods by defining SR as abscissa and v as ordinate and plotting two curves of them. Secondly, comparisons of the efficiency curve in RCC-MR and methods in ASME-NH APPENDIX T are investigated, with significant creep. At last, two practical evaluations are performed to show the comparisons of aforementioned methods. (authors)

  3. Terahertz electric field driven electric currents and ratchet effects in graphene

    Energy Technology Data Exchange (ETDEWEB)

    Ganichev, Sergey D.; Weiss, Dieter; Eroms, Jonathan [Terahertz Center, University of Regensburg (Germany)

    2017-11-15

    Terahertz field induced photocurrents in graphene were studied experimentally and by microscopic modeling. Currents were generated by cw and pulsed laser radiation in large area as well as small-size exfoliated graphene samples. We review general symmetry considerations leading to photocurrents depending on linear and circular polarized radiation and then present a number of situations where photocurrents were detected. Starting with the photon drag effect under oblique incidence, we proceed to the photogalvanic effect enhancement in the reststrahlen band of SiC and edge-generated currents in graphene. Ratchet effects were considered for in-plane magnetic fields and a structure inversion asymmetry as well as for graphene with non-symmetric patterned top gates. Lastly, we demonstrate that graphene can be used as a fast, broadband detector of terahertz radiation. (copyright 2017 by WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  4. A Simple Method to Measure Nematodes' Propulsive Thrust and the Nematode Ratchet.

    Science.gov (United States)

    Bau, Haim; Yuan, Jinzhou; Raizen, David

    2015-11-01

    Since the propulsive thrust of micro organisms provides a more sensitive indicator of the animal's health and response to drugs than motility, a simple, high throughput, direct measurement of the thrust is desired. Taking advantage of the nematode C. elegans being heavier than water, we devised a simple method to determine the propulsive thrust of the animals by monitoring their velocity when swimming along an inclined plane. We find that the swimming velocity is a linear function of the sin of the inclination angle. This method allows us to determine, among other things, the animas' propulsive thrust as a function of genotype, drugs, and age. Furthermore, taking advantage of the animals' inability to swim over a stiff incline, we constructed a sawteeth ratchet-like track that restricts the animals to swim in a predetermined direction. This research was supported, in part, by NIH NIA Grant 5R03AG042690-02.

  5. Chaotic Dynamics of a Josephson Junction with a Ratchet Potential and Current-Modulating Damping

    Science.gov (United States)

    Li, Fei; Li, Wenwu; Xu, Lan

    2018-04-01

    The chaotic dynamics of a Josephson junction with a ratchet potential and current-modulating damping are studied. Under the first-order approximation, we construct the general solution of the first-order equation whose boundedness condition contains the famous Melnikov chaotic criterion. Based on the general solution, the incomputability and unpredictability of the system's chaotic behavior are discussed. For the case beyond perturbation conditions, the evolution of stroboscopic Poincaré sections shows that the system undergoes a quasi-periodic transition to chaos with an increasing intensity of the rf-current. Through a suitable feedback controlling strategy, the chaos can be effectively suppressed and the intensity of the controller can vary in a large range. It is also found that the current between the two separated superconductors increases monotonously in some specific parameter spaces.

  6. Asymmetric step-like characteristics in a tilted rocking ratchet potential

    International Nuclear Information System (INIS)

    Lee, A. Khangjune; Lee, Jong-Rim; Lee, K.H.

    2012-01-01

    The overdamped Langevin dynamics has been employed to study the directional transport of particles driven in a tilted rocking ratchet potential. The system subjected to a constant direct force undergoes an asymmetrical dynamic transition from a static state to a sliding state at two different critical forces that are consistent with the predicted values. When an additional alternating force is applied to the system, the time-averaged velocity shows several steps of equal height as the direct force increases. These steps are similar to the Shapiro steps in an rf-driven Josephson junction, and appear whenever the system's natural frequency given by the direct force matches an integer multiple of the applied frequency. When the alternating force exceeds a certain critical value which can be also estimated for a slow rocking, a directional motion known as the rectification effect occurs even at zero direct force.

  7. Effect of ratchet strain on fatigue and creep–fatigue strength of Mod.9Cr–1Mo steel

    International Nuclear Information System (INIS)

    Ando, Masanori; Isobe, Nobuhiro; Kikuchi, Koichi; Enuma, Yasuhiro

    2012-01-01

    Highlights: ► Uniaxial fatigue and creep–fatigue tests with superimposed strain were performed. ► Variety of superimposed strain were applied as ratchet strain in the tests. ► Effect of superimposed strain on fatigue and creep–fatigue life is negligible. ► A cyclic softening character reducing the effect of superimposed strain. - Abstract: The effect of ratcheting deformation on fatigue and creep–fatigue life in Mod.9Cr–1Mo steel was investigated. Uniaxial fatigue and creep–fatigue testing with superimposed strain were performed to evaluate the effect of ratcheting deformation on the failure cycle. In a series of tests, a specific amount of superimposed strain was accumulated in each cycle. The accumulated strain as ratcheting deformation, cycles to reach the accumulated strain, and test temperatures were varied in the tests. In the fatigue tests with superimposed strain at 550 °C, slight reductions of failure lives were observed. All of the numbers of cycles to failure in the fatigue tests with superimposed strain were within a factor of 1.5 of that of the fatigue test without superimposed strain at 550 °C. The apparent relationship between failure cycles and testing parameters was not observed. In fatigue tests with superimposed strain at 550 °C, maximum mean stress was insignificant and generated in early cycles because Mod.9Cr–1Mo steel exhibits cyclic softening characteristics. It was assumed that suppression of mean stress generation by cyclic softening reduces the effect of ratcheting strain. Conversely, failure lives were increased by accumulated strain in the test conducted at 450 °C because of stress–strain hysteresis loop shrinkage caused by cyclic softening induced by the accumulated strain. In the creep–fatigue tests with superimposed strain, test results indicated that the accumulated stain was negligible. It was concluded that the effect of ratcheting deformation on fatigue and creep–fatigue life is negligible as long

  8. Continuous-flow system and monitoring tools for the dielectrophoretic integration of nanowires in light sensor arrays.

    Science.gov (United States)

    Marín, A García; Núñez, C García; Rodríguez, P; Shen, G; Kim, S M; Kung, P; Piqueras, J; Pau, J L

    2015-03-20

    Although nanowires (NWs) may improve the performance of many optoelectronic devices such as light emitters and photodetectors, the mass commercialization of these devices is limited by the difficult task of finding reliable and reproducible methods to integrate the NWs on foreign substrates. This work shows the fabrication of zinc oxide NWs photodetectors on conventional glass using transparent conductive electrodes to effectively integrate the NWs at specific locations by dielectrophoresis (DEP). The paper describes the careful preparation of NW dispersions by sedimentation and the dielectrophoretic alignment of NWs in a home-made system. This system includes an impedance technique for the assessment of the alignment quality in real time. Following this procedure, ultraviolet photodetectors based on the electrical contacts formed by the DEP process on the transparent electrodes are fabricated. This cost-effective mean of contacting NWs enables front-and back-illumination operation modes, the latter eliminating shadowing effects caused by the deposition of metals. The electro-optical characterization of the devices shows uniform responsivities in the order of 106 A W(-1) below 390 nm under both modes, as well as, time responses of a few seconds.

  9. How does a scanning ribosomal particle move along the 5'-untranslated region of eukaryotic mRNA? Brownian Ratchet model.

    Science.gov (United States)

    Spirin, Alexander S

    2009-11-17

    A model of the ATP-dependent unidirectional movement of the 43S ribosomal initiation complex (=40S ribosomal subunit + eIF1 + eIF1A + eIF2.GTP.Met-tRNA(i) + eIF3) during scanning of the 5'-untranslated region of eukaryotic mRNA is proposed. The model is based on the principles of molecular Brownian ratchet machines and explains several enigmatic data concerning the scanning complex. In this model, the one-dimensional diffusion of the ribosomal initiation complex along the mRNA chain is rectified into the net-unidirectional 5'-to-3' movement by the Feynman ratchet-and-pawl mechanism. The proposed mechanism is organized by the heterotrimeric protein eIF4F (=eIF4A + eIF4E + eIF4G), attached to the scanning ribosomal particle via eIF3, and the RNA-binding protein eIF4B that is postulated to play the role of the pawl. The energy for the useful work of the ratchet-and-pawl mechanism is supplied from ATP hydrolysis induced by the eIF4A subunit: ATP binding and its hydrolysis alternately change the affinities of eIF4A for eIF4B and for mRNA, resulting in the restriction of backward diffusional sliding of the 43S ribosomal complex along the mRNA chain, while stochastic movements ahead are allowed.

  10. Analytical investigation of the applicability of simplified ratchetting and creep-fatigue rules to a nozzle-to-sphere geometry

    International Nuclear Information System (INIS)

    Gwaltney, R.C.

    1982-01-01

    This paper presents an analysis of a nozzle-to-spherical-shell attachment and explores the applicability of simplified ratchetting and creep-fatigue rules to this attachment. A five-cycle inelastic analysis and creep-fatigue damage evaluation was carried out on this component. An elastic analysis also was done to provide input parameters required to apply the various rules and procedures of simplified analysis methods. Ten lines, or critical sections, were chosen for postprocessing to determine the ratchetting strain and creep-fatigue damage at both the inside and outside surfaces. At many of the 20 surface points analyzed, the inelastic analysis results did not develop a constant or decreasing pattern for the incremental strain or damage even after 5 cycles were analyzed. Failure to develop a constant or decreasing pattern was especially prevalent for creep damage. The results of the detailed inelastic analyses at the ten critical sections are compared with the results of elastic evaluations of ratchetting and creep-fatigue damage calculated according to American Society of Mechanical Engineers Boiler and Pressure Vessel Code Case N-47-13

  11. Bio-field array: a dielectrophoretic electromagnetic toroidal excitation to restore and maintain the golden ratio in human erythrocytes.

    Science.gov (United States)

    Purnell, Marcy C; Butawan, Matthew B A; Ramsey, Risa D

    2018-06-01

    Erythrocytes must maintain a biconcave discoid shape in order to efficiently deliver oxygen (O 2 ) molecules and to recycle carbon dioxide (CO 2 ) molecules. The erythrocyte is a small toroidal dielectrophoretic (DEP) electromagnetic field (EMF) driven cell that maintains its zeta potential (ζ) with a dielectric constant (ԑ) between a negatively charged plasma membrane surface and the positively charged adjacent Stern layer. Here, we propose that zeta potential is also driven by both ferroelectric influences (chloride ion) and ferromagnetic influences (serum iron driven). The Golden Ratio, a function of Phi φ, offers a geometrical mathematical measure within the distinct and desired curvature of the red blood cell that is governed by this zeta potential and is required for the efficient recycling of CO 2 in our bodies. The Bio-Field Array (BFA) shows potential to both drive/fuel the zeta potential and restore the Golden Ratio in human erythrocytes thereby leading to more efficient recycling of CO 2 . Live Blood Analyses and serum CO 2 levels from twenty human subjects that participated in immersion therapy sessions with the BFA for 2 weeks (six sessions) were analyzed. Live Blood Analyses (LBA) and serum blood analyses performed before and after the BFA immersion therapy sessions in the BFA pilot study participants showed reversal of erythrocyte rheological alterations (per RBC metric; P = 0.00000075), a morphological return to the Golden Ratio and a significant decrease in serum CO 2 (P = 0.017) in these participants. Immersion therapy sessions with the BFA show potential to modulate zeta potential, restore this newly defined Golden Ratio and reduce rheological alterations in human erythrocytes. © 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

  12. Effect of island shape on dielectrophoretic assembly of metal nanoparticle chains in a conductive-island-based microelectrode system

    International Nuclear Information System (INIS)

    Ding, Haitao; Shao, Jinyou; Ding, Yucheng; Liu, Weiyu; Li, Xiangming; Tian, Hongmiao; Zhou, Yaopei

    2015-01-01

    Highlights: • Conductive island shape influences the dynamic process occurring in DEP assembly of 10 nm gold nanoparticles in a conductive-island-based microelectrode system. • The DEP-assembled nanoparticle wires form a straighter conduction path with the increase in the geometric angle of conductive island tip. • The different island shapes distort the DEP force distribution and increase the local electrothermally induced fluid flow to different extents, which is important for the morphology and electrical conductance quality of the DEP-assembled metal nanoparticle chains. - Abstract: The electrical conduction quality of an electric circuit connection formed by dielectrophoretic (DEP)-assembled metal nanoparticle wires between small conductive elements plays a significant role in electronic devices. One of the major challenges for improving the electrical conductance of nanowires is optimizing their geometric morphology. So far, the electrical conduction quality has been enhanced by optimizing the AC frequency and conductivity of nanoparticle suspensions. Herein, the effect of the conductive island shapes on the dynamic process occurring in a DEP assembly of 10 nm gold nanoparticles was investigated in a conductive-island-based microelectrode system. The nanoparticle wires between the microelectrodes were assembled in situ from colloidal suspensions. The wires were grown in a much straighter route by increasing the geometric angle of the conductive-island tip. To validate the experiments, the effects of mutual DEP interactions and electrothermally induced fluid flow on the dynamic behavior of particle motion for different island geometric configurations in the conductive-island-based microelectrode system were determined by numerical simulations. The simulation results are consistent with those of experiments. This indicates that different conductive island shapes change the distribution of DEP force and increase the electrothermally induced fluid flow to

  13. Asymmetric ratchet effect for directional transport of fog drops on static and dynamic butterfly wings.

    Science.gov (United States)

    Liu, Chengcheng; Ju, Jie; Zheng, Yongmei; Jiang, Lei

    2014-02-25

    Inspired by novel creatures, researchers have developed varieties of fog drop transport systems and made significant contributions to the fields of heat transferring, water collecting, antifogging, and so on. Up to now, most of the efforts in directional fog drop transport have been focused on static surfaces. Considering it is not practical to keep surfaces still all the time in reality, conducting investigations on surfaces that can transport fog drops in both static and dynamic states has become more and more important. Here we report the wings of Morpho deidamia butterflies can directionally transport fog drops in both static and dynamic states. This directional drop transport ability results from the micro/nano ratchet-like structure of butterfly wings: the surface of butterfly wings is composed of overlapped scales, and the scales are covered with porous asymmetric ridges. Influenced by this special structure, fog drops on static wings are transported directionally as a result of the fog drops' asymmetric growth and coalescence. Fog drops on vibrating wings are propelled directionally due to the fog drops' asymmetric dewetting from the wings.

  14. Controlling Heat Transport and Flow Structures in Thermal Turbulence Using Ratchet Surfaces

    Science.gov (United States)

    Jiang, Hechuan; Zhu, Xiaojue; Mathai, Varghese; Verzicco, Roberto; Lohse, Detlef; Sun, Chao

    2018-01-01

    In this combined experimental and numerical study on thermally driven turbulence in a rectangular cell, the global heat transport and the coherent flow structures are controlled with an asymmetric ratchetlike roughness on the top and bottom plates. We show that, by means of symmetry breaking due to the presence of the ratchet structures on the conducting plates, the orientation of the large scale circulation roll (LSCR) can be locked to a preferred direction even when the cell is perfectly leveled out. By introducing a small tilt to the system, we show that the LSCR orientation can be tuned and controlled. The two different orientations of LSCR give two quite different heat transport efficiencies, indicating that heat transport is sensitive to the LSCR direction over the asymmetric roughness structure. Through a quantitative analysis of the dynamics of thermal plume emissions and the orientation of the LSCR over the asymmetric structure, we provide a physical explanation for these findings. The current work has important implications for passive and active flow control in engineering, biofluid dynamics, and geophysical flows.

  15. Stochastic Stokes' Drift, Homogenized Functional Inequalities, and Large Time Behavior of Brownian Ratchets

    KAUST Repository

    Blanchet, Adrien

    2009-01-01

    A periodic perturbation of a Gaussian measure modifies the sharp constants in Poincarae and logarithmic Sobolev inequalities in the homogeniz ation limit, that is, when the period of a periodic perturbation converges to zero. We use variational techniques to determine the homogenized constants and get optimal convergence rates toward s equilibrium of the solutions of the perturbed diffusion equations. The study of these sharp constants is motivated by the study of the stochastic Stokes\\' drift. It also applies to Brownian ratchets and molecular motors in biology. We first establish a transport phenomenon. Asymptotically, the center of mass of the solution moves with a constant velocity, which is determined by a doubly periodic problem. In the reference frame attached to the center of mass, the behavior of the solution is governed at large scale by a diffusion with a modified diffusion coefficient. Using the homogenized logarithmic Sobolev inequality, we prove that the solution converges in self-similar variables attached to t he center of mass to a stationary solution of a Fokker-Planck equation modulated by a periodic perturbation with fast oscillations, with an explicit rate. We also give an asymptotic expansion of the traveling diffusion front corresponding to the stochastic Stokes\\' drift with given potential flow. © 2009 Society for Industrial and Applied Mathematics.

  16. Current-driven domain wall motion based memory devices: Application to a ratchet ferromagnetic strip

    Science.gov (United States)

    Sánchez-Tejerina, Luis; Martínez, Eduardo; Raposo, Víctor; Alejos, Óscar

    2018-04-01

    Ratchet memories, where perpendicular magnetocristalline anisotropy is tailored so as to precisely control the magnetic transitions, has been recently proven to be a feasible device to store and manipulate data bits. For such devices, it has been shown that the current-driven regime of domain walls can improve their performances with respect to the field-driven one. However, the relaxing time required by the traveling domain walls constitutes a certain drawback if the former regime is considered, since it results in longer device latencies. In order to speed up the bit shifting procedure, it is demonstrated here that the application of a current of inverse polarity during the DW relaxing time may reduce such latencies. The reverse current must be sufficiently high as to drive the DW to the equilibrium position faster than the anisotropy slope itself, but with an amplitude sufficiently low as to avoid DW backward shifting. Alternatively, it is possible to use such a reverse current to increase the proper range of operation for a given relaxing time, i.e., the pair of values of the current amplitude and pulse time that ensures single DW jumps for a certain latency time.

  17. Cyclic creep, mechanical ratchetting and amplitude history dependence of modified 9Cr-1Mo steel and evaluation of unified constitutive models

    International Nuclear Information System (INIS)

    Tanaka, Eiichi; Yamada, Hiroshi

    1993-01-01

    The purpose of the present paper is to elucidate inelastic behavior of modified 9Cr-1Mo steel as a candidate material for the next-generation fast breeder reactor and to provide the information for the formulation of a unified constitutive model. For this purpose, cyclic creep, mechanical ratchetting and amplitude history dependence of cyclic hardening were first examined at 550degC. As a result, systematic cyclic creep and mechanical ratchetting behavior were observed under various loading conditions, and little amplitude history dependence was found. Then these results were simulated by three unified constitutive models, i.e. the Chaboche, Bodner-Partom and modified Chaboche models. The simulated results show that these models cannot describe the cyclic creep and mechanical ratchetting behavior with high accuracy, but succeed in describing the inelastic behavior of amplitude variation experiments. (author)

  18. Contribution to the validation of thermal ratchetting prevision methods in metallic structures

    International Nuclear Information System (INIS)

    Rakotovelo, A.M.

    1998-03-01

    This work concerns the steady state assessment in the metallic structures subjected to thermomechanical cyclic loadings in biaxial stress state. The effect of the short time mechanical overloads is also investigated. The first chapter is devoted to a bibliographic research concerning the behaviour of the materials and the structures in the cyclic plasticity. Some works relate to the experimental aspect as well as the numerical one for the steady state assessment of such structures are presented. The experimental part of the study is presented in the second chapter. The experimental device was carried out in order to prescribe tension and torsion forces combined with cyclic thermal loading. Some tests was then carried out, among these tests certain include some overloads in tension or torsion. The last chapter describes the numerical calculations using different models (linear isotropic hardening, linear kinematic hardening and elasto-viscoplastic Chaboche's model) and the application of some simplified methods for the ratchetting assessment in the structures. We have considered two categories of methods. The first one is based on an elastic analysis (Bree's diagram, 3 Sm rule, efficiency rule) and the second one combines elastic analysis and elastoplastic analysis of the first cycle (Gatt's and Taleb's methods). The results of this study have enabled: to validate in the biaxial stress state an expression which takes into account the effect of mechanical short time overloads; to test the performances of considered models to describe the evolution of the structure during the first cycle and to take into account the effect of short time overloads. Among the considered models, the elastoplastic Chaboche's model seems to be the most accurate to describe the structure's behaviour during the first cycles; to validate some simplified methods. Certain methods based only on elastic analysis (Bee's diagram and efficiency rule) seem not suitable for the considered kind of

  19. Ratchet Effects and Domain Wall Energy Landscapes in Amorphous Magnetic Films with 2D Arrays of Asymmetric Holes

    Science.gov (United States)

    Martin, J. I.; Alija, A.; Sobrado, I.; Perez-Junquera, A.; Rodriguez-Rodriguez, G.; Velez, M.; Alameda, J. M.; Marconi, V. I.; Kolton, A. B.; Parrondo, J. M. R.

    2009-03-01

    The driven motion of domain walls in extended magnetic films patterned with 2D arrays of asymmetric holes has been found to be subject to two different crossed ratchet effects [1] which results in an inversion of the sign of domain wall motion rectification as a function of the applied magnetic field. This effect can be understood in terms of the competition between drive, elasticity and asymmetric pinning as revealed by a simple 4̂-model. In order to optimize the asymmetric hole design, the relevant energy landscapes for domain wall motion across the array of asymmetric holes have been calculated by micromagnetic simulations as a function of array geometrical characteristics. The effects of a transverse magnetic field on these two crossed ratchet effects will also be discussed in terms of the decrease in domain wall energy per unit area and of the modifications in the magnetostatic barriers for domain wall pinning at the asymmetric inclusions. Work supported by Spanish MICINN.[1] A. Perez-Junquera et al, Phys. Rev. Lett. 100 (2008) 037203

  20. A cyclic constitutive law for metals with a semi-discrete memory variable for description of ratcheting phenomena

    International Nuclear Information System (INIS)

    Andrieux, S.; Schoenberger, P.; Taheri, S.

    1993-01-01

    The study of cyclic elastoplastic constitutive laws is, at the moment, focused on non proportional loadings, but for uniaxial loadings some problems remain, as for example the ability for a law to describe simultaneously ratcheting in non symmetrical load-controlled test, elastic and plastic shakedown in symmetrical and non symmetrical ones. We have proposed in a law with a discrete memory variable which, in addition to previous phenomena, describes the cyclic hardening in a pushpull test, and the cyclic softening after overloading. A modified law has been proposed to take into account the dependence of cyclic strain stress curve on the history of loading. The extension to 3D situations of this law is proposed. The discrete nature of the memory leads to discontinuity problems for some loading paths, a modification is then proposed which uses a differential evolution law. For large enough uniaxial cycles, the uniaxial law is nevertheless recovered. In this paper, an incremental form of the implicit evolution problem is given, and we describe the implementation of this model in the Code Aster - a thermomechanical structural software using the finite element method (f.e.m) developed at Electricite de France. Comparison between experiment and numerical results is given for uniaxial ratcheting, non proportional strain controlled test

  1. Numerical comparison between Maxwell stress method and equivalent multipole approach for calculation of the dielectrophoretic force in single-cell traps.

    Science.gov (United States)

    Rosales, Carlos; Lim, Kian Meng

    2005-06-01

    This paper presents detailed numerical calculations of the dielectrophoretic force in traps designed for single-cell trapping. A trap with eight planar electrodes is studied for spherical and ellipsoidal particles using the boundary element method (BEM). Multipolar approximations of orders one to three are compared with the full Maxwell stress tensor (MST) calculation of the electrical force on spherical particles. Ellipsoidal particles are also studied, but in their case only the dipolar approximation is available for comparison with the MST solution. The results show that a small number of multipolar terms need to be considered in order to obtain accurate results for spheres, even in the proximity of the electrodes, and that the full MST calculation is only required in the study of non-spherical particles.

  2. Fabrication of dielectrophoretic microfluidic chips using a facile screen-printing technique for microparticle trapping

    International Nuclear Information System (INIS)

    Wee, Wei Hong; Kadri, Nahrizul Adib; Pingguan-Murphy, Belinda; Li, Zedong; Hu, Jie; Xu, Feng; Li, Fei

    2015-01-01

    Trapping of microparticles finds wide applications in numerous fields. Microfluidic chips based on a dielectrophoresis (DEP) technique hold several advantages for trapping microparticles, such as fast result processing, a small amount of sample required, high spatial resolution, and high accuracy of target selection. There is an unmet need to develop DEP microfluidic chips on different substrates for different applications in a low cost, facile, and rapid way. This study develops a new facile method based on a screen-printing technique for fabrication of electrodes of DEP chips on three types of substrates (i.e. polymethyl-methacrylate (PMMA), poly(ethylene terephthalate) and A4 paper). The fabricated PMMA-based DEP microfluidic chip was selected as an example and successfully used to trap and align polystyrene microparticles in a suspension and cardiac fibroblasts in a cell culture solution. The developed electrode fabrication method is compatible with different kinds of DEP substrates, which could expand the future application field of DEP microfluidic chips, including new forms of point-of care diagnostics and trapping circulating tumor cells. (paper)

  3. Multiaxial Creep-Fatigue and Creep-Ratcheting Failures of Grade 91 and Haynes 230 Alloys Toward Addressing Design Issues of Gen IV Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Hassan, Tasnim [North Carolina State Univ., Raleigh, NC (United States); Lissenden, Cliff [Penn State Univ., University Park, PA (United States); Carroll, Laura [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-04-01

    The proposed research will develop systematic sets of uniaxial and multiaxial experimental data at a very high temperature (850-950°C) for Alloy 617. The loading histories to be prescribed in the experiments will induce creep-fatigue and creep-ratcheting failure mechanisms. These experimental responses will be scrutinized in order to quantify the influences of temperature and creep on fatigue and ratcheting failures. A unified constitutive model (UCM) will be developed and validated against these experimental responses. The improved UCM will be incorporated into the widely used finite element commercial software packages ANSYS. The modified ANSYS will be validated so that it can be used for evaluating the very high temperature ASME-NH design-by-analysis methodology for Alloy 617 and thereby addressing the ASME-NH design code issues.

  4. Multiaxial Creep-Fatigue and Creep-Ratcheting Failures of Grade 91 and Haynes 230 Alloys Toward Addressing Design Issues of Gen IV Nuclear Power Plants

    International Nuclear Information System (INIS)

    Hassan, Tasnim; Lissenden, Cliff; Carroll, Laura

    2015-01-01

    The proposed research will develop systematic sets of uniaxial and multiaxial experimental data at a very high temperature (850-950°C) for Alloy 617. The loading histories to be prescribed in the experiments will induce creep-fatigue and creep-ratcheting failure mechanisms. These experimental responses will be scrutinized in order to quantify the influences of temperature and creep on fatigue and ratcheting failures. A unified constitutive model (UCM) will be developed and validated against these experimental responses. The improved UCM will be incorporated into the widely used finite element commercial software packages ANSYS. The modified ANSYS will be validated so that it can be used for evaluating the very high temperature ASME-NH design-by-analysis methodology for Alloy 617 and thereby addressing the ASME-NH design code issues.

  5. On-chip concentration of bacteria using a 3D dielectrophoretic chip and subsequent laser-based DNA extraction in the same chip

    International Nuclear Information System (INIS)

    Cho, Yoon-Kyoung; Kim, Tae-hyeong; Lee, Jeong-Gun

    2010-01-01

    We report the on-chip concentration of bacteria using a dielectrophoretic (DEP) chip with 3D electrodes and subsequent laser-based DNA extraction in the same chip. The DEP chip has a set of interdigitated Au post electrodes with 50 µm height to generate a network of non-uniform electric fields for the efficient trapping by DEP. The metal post array was fabricated by photolithography and subsequent Ni and Au electroplating. Three model bacteria samples (Escherichia coli, Staphylococcus epidermidis, Streptococcus mutans) were tested and over 80-fold concentrations were achieved within 2 min. Subsequently, on-chip DNA extraction from the concentrated bacteria in the 3D DEP chip was performed by laser irradiation using the laser-irradiated magnetic bead system (LIMBS) in the same chip. The extracted DNA was analyzed with silicon chip-based real-time polymerase chain reaction (PCR). The total process of on-chip bacteria concentration and the subsequent DNA extraction can be completed within 10 min including the manual operation time.

  6. Calcium-Driven Folding of RTX Domain beta-Rolls Ratchets Translocation of RTX Proteins through Type I Secretion Ducts

    Czech Academy of Sciences Publication Activity Database

    Bumba, Ladislav; Mašín, Jiří; Macek, Pavel; Wald, Tomáš; Motlová, Lucia; Bíbová, Ilona; Klímová, Nela; Bednárová, Lucie; Veverka, Václav; Kachala, M.; Svergun, D. I.; Bařinka, Cyril; Šebo, Peter

    2016-01-01

    Roč. 62, č. 1 (2016), s. 47-62 ISSN 1097-2765 R&D Projects: GA MŠk(CZ) LK11205; GA MŠk(CZ) LO1304; GA ČR(CZ) GA15-11851S; GA ČR GA13-14547S; GA ČR GAP302/12/0460; GA ČR(CZ) GAP207/11/0717; GA MŠk(CZ) ED1.1.00/02.0109 Institutional support: RVO:61388971 ; RVO:61388963 ; RVO:86652036 Keywords : ADENYLATE-CYCLASE TOXIN * GRAM-NEGATIVE BACTERIA * BORDETELLA-PERTUSSIS Subject RIV: CE - Biochemistry ; EB - Genetics ; Molecular Biology (BTO-N); CE - Biochemistry (UOCHB-X) Impact factor: 14.714, year: 2016

  7. Monitoring microstructural evolution of alloy 617 with non-linear acoustics for remaining useful life prediction; multiaxial creep-fatigue and creep-ratcheting

    Energy Technology Data Exchange (ETDEWEB)

    Lissenden, Cliff [Pennsylvania State Univ., State College, PA (United States); Hassan, Tasnin [North Carolina State Univ., Raleigh, NC (United States); Rangari, Vijaya [Tuskegee Univ., Tuskegee, AL (United States)

    2014-10-30

    The research built upon a prior investigation to develop a unified constitutive model for design-­by-­analysis of the intermediate heat exchanger (IHX) for a very high temperature reactor (VHTR) design of next generation nuclear plants (NGNPs). Model development requires a set of failure data from complex mechanical experiments to characterize the material behavior. Therefore uniaxial and multiaxial creep-­fatigue and creep-­ratcheting tests were conducted on the nickel-­base Alloy 617 at 850 and 950°C. The time dependence of material behavior, and the interaction of time dependent behavior (e.g., creep) with ratcheting, which is an increase in the cyclic mean strain under load-­controlled cycling, are major concerns for NGNP design. This research project aimed at characterizing the microstructure evolution mechanisms activated in Alloy 617 by mechanical loading and dwell times at elevated temperature. The acoustic harmonic generation method was researched for microstructural characterization. It is a nonlinear acoustics method with excellent potential for nondestructive evaluation, and even online continuous monitoring once high temperature sensors become available. It is unique because it has the ability to quantitatively characterize microstructural features well before macroscale defects (e.g., cracks) form. The nonlinear acoustics beta parameter was shown to correlate with microstructural evolution using a systematic approach to handle the complexity of multiaxial creep-­fatigue and creep-­ratcheting deformation. Mechanical testing was conducted to provide a full spectrum of data for: thermal aging, tensile creep, uniaxial fatigue, uniaxial creep-­fatigue, uniaxial creep-ratcheting, multiaxial creep-fatigue, and multiaxial creep-­ratcheting. Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), and Optical Microscopy were conducted to correlate the beta parameter with individual microstructure mechanisms. We researched

  8. Monitoring microstructural evolution of alloy 617 with non-linear acoustics for remaining useful life prediction; multiaxial creep-fatigue and creep-ratcheting

    International Nuclear Information System (INIS)

    Lissenden, Cliff; Hassan, Tasnin; Rangari, Vijaya

    2014-01-01

    The research built upon a prior investigation to develop a unified constitutive model for design-@by-@analysis of the intermediate heat exchanger (IHX) for a very high temperature reactor (VHTR) design of next generation nuclear plants (NGNPs). Model development requires a set of failure data from complex mechanical experiments to characterize the material behavior. Therefore uniaxial and multiaxial creep-@fatigue and creep-@ratcheting tests were conducted on the nickel base Alloy 617 at 850 and 950°C. The time dependence of material behavior, and the interaction of time dependent behavior (e.g., creep) with ratcheting, which is an increase in the cyclic mean strain under load-@controlled cycling, are major concerns for NGNP design. This research project aimed at characterizing the microstructure evolution mechanisms activated in Alloy 617 by mechanical loading and dwell times at elevated temperature. The acoustic harmonic generation method was researched for microstructural characterization. It is a nonlinear acoustics method with excellent potential for nondestructive evaluation, and even online continuous monitoring once high temperature sensors become available. It is unique because it has the ability to quantitatively characterize microstructural features well before macroscale defects (e.g., cracks) form. The nonlinear acoustics beta parameter was shown to correlate with microstructural evolution using a systematic approach to handle the complexity of multiaxial creep-@fatigue and creep-@ratcheting deformation. Mechanical testing was conducted to provide a full spectrum of data for: thermal aging, tensile creep, uniaxial fatigue, uniaxial creep-@fatigue, uniaxial creep-ratcheting, multiaxial creep-fatigue, and multiaxial creep-@ratcheting. Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), and Optical Microscopy were conducted to correlate the beta parameter with individual microstructure mechanisms. We researched application of the

  9. Ion pump as Brownian motor: theory of electroconformational coupling and proof of ratchet mechanism for Na,K-ATPase action

    Science.gov (United States)

    Tsong, Tian Yow; Chang, Cheng-Hung

    2003-04-01

    This article reviews some concepts of the Brownian Ratchet which are relevant to our discussion of mechanisms of action of Na,K-ATPase, a universal ion pump and an elemental motor protein of the biological cell. Under wide ranges of ionic compositions it can hydrolyze an ATP and use the γ-phosphorous bond energy of ATP to pump 3 Na + out of, and 2 K + into the cell, both being uphill transport. During the ATP-dependent pump cycle, the enzyme oscillates between E1 and E2 states. Our experiment replaces ATP with externally applied electric field of various waveforms, amplitudes, and frequencies. The field enforced-oscillation, or fluctuation of E1 and E2 states enables the enzyme to harvest energy from the applied field and convert it to the chemical gradient energy of cations. A theory of electroconformational coupling (TEC), which embodies all the essential features of the Brownian Ratchet, successfully simulates these experimental results. Our analysis based on a four-state TEC model indicates that the equilibrium and the rate constants of the transport system define the frequency and the amplitude of the field for the optimal activation. Waveform, frequency, and amplitude are three elements of signal. Thus, electric signal of the ion pump is found by TEC analysis of the experimental data. Electric noise (white) superimposed on an electric signal changes the pump efficiency and produces effects similar to the stochastic resonance reported in other biological systems. The TEC concept is compared with the most commonly used Michaelis-Menten enzyme mechanism (MME) for similarities and differences. Both MME and TEC are catalytic wheels, which recycle the catalyst in each turnover. However, a MME can only catalyze reaction of descending free energy while a TEC enzyme can catalyze reaction of ascending free energy by harvesting needed energy from an off-equilibrium electric noise. The TEC mechanism is shown to be applicable to other biological motors and engines, as

  10. Modelling of ratchetting with the Chaboche elastoplastic model modified by Burlet and Cailletaud; Modelisation des phenomenes de deformation progressive par le modele elastoplastique de Chaboche modifie par Burlet et Cailletaud

    Energy Technology Data Exchange (ETDEWEB)

    Geyer, P

    1994-01-01

    A fine modelling of the material`s behaviour can be necessary to study the mechanical strength of nuclear power plant`s components under cyclic loads. The modelling of cyclic plasticity made great progress during the past 20 years. Ratchetting is one of the last phenomena for which numerical models have to be improved. We give in this document a state of the art report on research in this field. We notably show the basically different character of ratchetting in uniaxial and biaxial loading tests, usually distinguished as 1D and 2D ratchetting. On the basis of this overview, we selected the kinematic hardening formulation proposed by Burlet and Cailletaud, which we coupled with the Chaboche elastoplastic model with two non linear kinematic hardening variables to improve the modelling of 2D ratchetting. We use the experimental results on the austenitic steel 316L at 20 and 300 deg C under uniaxial loadings (low cycle fatigue) and biaxial loadings (traction-torsion) to study the new model capabilities. We get a good modelling of ratchetting in biaxial loadings. The model has been installed in the ASTER code under the name of UBRLET. It now has to be qualified by component analysis calculations. (author). 25 refs., 30 figs., 11 tabs., 3 annexes.

  11. Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation.

    Science.gov (United States)

    Allen, William John; Corey, Robin Adam; Oatley, Peter; Sessions, Richard Barry; Baldwin, Steve A; Radford, Sheena E; Tuma, Roman; Collinson, Ian

    2016-05-16

    The essential process of protein secretion is achieved by the ubiquitous Sec machinery. In prokaryotes, the drive for translocation comes from ATP hydrolysis by the cytosolic motor-protein SecA, in concert with the proton motive force (PMF). However, the mechanism through which ATP hydrolysis by SecA is coupled to directional movement through SecYEG is unclear. Here, we combine all-atom molecular dynamics (MD) simulations with single molecule FRET and biochemical assays. We show that ATP binding by SecA causes opening of the SecY-channel at long range, while substrates at the SecY-channel entrance feed back to regulate nucleotide exchange by SecA. This two-way communication suggests a new, unifying 'Brownian ratchet' mechanism, whereby ATP binding and hydrolysis bias the direction of polypeptide diffusion. The model represents a solution to the problem of transporting inherently variable substrates such as polypeptides, and may underlie mechanisms of other motors that translocate proteins and nucleic acids.

  12. Double-lock ratchet mechanism revealing the role of  SER-344 in FoF1 ATP synthase

    KAUST Repository

    Beke-Somfai, T.

    2011-03-07

    In a majority of living organisms, FoF1 ATP synthase performs the fundamental process of ATP synthesis. Despite the simple net reaction formula, ADP+Pi→ATP+H2O, the detailed step-by-step mechanism of the reaction yet remains to be resolved owing to the complexity of this multisubunit enzyme. Based on quantum mechanical computations using recent high resolution X-ray structures, we propose that during ATP synthesis the enzyme first prepares the inorganic phosphate for the γP-OADP bond-forming step via a double-proton transfer. At this step, the highly conserved αS344 side chain plays a catalytic role. The reaction thereafter progresses through another transition state (TS) having a planar ion configuration to finally form ATP. These two TSs are concluded crucial for ATP synthesis. Using stepwise scans and several models of the nucleotide-bound active site, some of the most important conformational changes were traced toward direction of synthesis. Interestingly, as the active site geometry progresses toward the ATP-favoring tight binding site, at both of these TSs, a dramatic increase in barrier heights is observed for the reverse direction, i.e., hydrolysis of ATP. This change could indicate a "ratchet" mechanism for the enzyme to ensure efficacy of ATP synthesis by shifting residue conformation and thus locking access to the crucial TSs.

  13. Ion pump as molecular ratchet and effects of noise: electric activation of cation pumping by Na,K-ATPase

    Science.gov (United States)

    Tsong, T. Y.; Xie, T. D.

    2002-08-01

    Na,K-ATPase is a universal ion pump of the biological cell. Under physiological conditions, it uses the γ-phosphorus bond energy of ATP during hydrolysis to pump 2 K+ inward and 3 Na+ outward; both being uphill transports. The experiment presented here demonstrates that the protein transporter can also use electric energy to fuel its pump activity. A theory of electroconformational coupling (TEC) is described and an experiment performed to verify several predictions of the model. Analysis based on the TEC model suggests that Na,K-ATPase is a Brownian ratchet. The enzyme harvests energy from the applied field by means of the field-induced conformational oscillation or fluctuation. However, high efficiency of energy transduction can only be achieved with an electric field of certain intensities, frequencies and waveforms. This property of the enzyme allows us to define an electric signal and differentiate it from electric noise on the basis of the analysis by the TEC model. Data show that electric noise alone does not induce pump activity. However, an appropriate power level of noise imposed on a signal can enhance the pump efficiency. The effect of noise on the signal transduction of Na,K-ATPase is reminiscent of the stochastic resonance phenomenon reported in other biological systems [3, 35]. The TEC model embodies many common features of enzymes and biological motors. It is potentially energy-efficient, much more so than models based on the ion-rectification mechanism.

  14. Design rules of mechanical structure of reactors. Damage due to cyclic loading. Progressive distortion. Practical analysis of ratcheting

    International Nuclear Information System (INIS)

    Clement, Gerard; Cousseran, Pierre; Lebey, Jacques; Moulin, Didier; Roche, Roland; Tremblais, Andre.

    1982-08-01

    At first is given a definition of what is ratcheting. A short discussion shows that computation results do not agree with experimental results. This is attributed to the complexity of the real material behavior. These considerations lead to try to build a design rule mainly based on the results of experimental tests. A large experimental program is in progress at CEN-Saclay. Using these results and the results available in open litterature, it was possible to propose a rule based on the concept of effective primary stress Psub(eff). The effective primary stress is a fictitious primary stress giving the same effects that the real loading (it is to say the same effect that the combination of an applied primary stress P and a cyclic straining). Determination of an upper bound value of Psub(eff) is made with the help of an efficiency diagram. More precisely the efficiency diagram include a curve giving a conservative value of an efficiency index V=P/Psub(eff) as a function of the secondary quotient SQ=ΔQ/P. Finally limitation of Psub(eff) intensity is discussed in regard with the current practice [fr

  15. Effects of the Reynolds number on two-dimensional dielectrophoretic motions of a pair of particles under a uniform electric field

    International Nuclear Information System (INIS)

    Kang, Sang Mo; Mannoor, Madhusoodanan; Maniyeri, Ranjith Maniyeri

    2016-01-01

    This paper presents two-dimensional direct numerical simulations to explore the effect of the Reynolds number on the Dielectrophoretic (DEP) motion of a pair of freely suspended particles in an unbounded viscous fluid under an external uniform electric field. Accordingly, the electric potential is obtained by solving the Maxwell'00s equation with a great sudden change in the electric conductivity at the particle-fluid interface and then the Maxwell stress tensor is integrated to determine the DEP force exerted on each particle. The fluid flow and particle movement, on the other hand, are predicted by solving the continuity and Navier-Stokes equations together with the kinetic equations. Numerical simulations are carried out using a finite volume approach, composed of a sharp interface method for the electric potential and a direct-forcing immersed-boundary method for the fluid flow. Through the simulations, it is found that both particles with the same sign of the conductivity revolve and eventually align themselves in a line with the electric field. With different signs, to the contrary, they revolve in the reverse way and eventually become lined up at a right angle with the electric field. The DEP motion also depends significantly on the Reynolds number defined based on the external electric field for all the combinations of the conductivity signs. When the Reynolds number is approximately below Re cr ≈ 0.1, the DEP motion becomes independent of the Reynolds number and thus can be exactly predicted by the no-inertia solver that neglects all the inertial and convective effects. With increasing Reynolds number above the critical number, on the other hand, the particles trace larger trajectories and thus take longer time during their revolution to the eventual in-line alignment.

  16. Effects of the Reynolds number on two-dimensional dielectrophoretic motions of a pair of particles under a uniform electric field

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Sang Mo; Mannoor, Madhusoodanan [Dong-A University, Busan (Korea, Republic of); Maniyeri, Ranjith Maniyeri [National Institute of Technology Karnataka, Mangalore (India)

    2016-07-15

    This paper presents two-dimensional direct numerical simulations to explore the effect of the Reynolds number on the Dielectrophoretic (DEP) motion of a pair of freely suspended particles in an unbounded viscous fluid under an external uniform electric field. Accordingly, the electric potential is obtained by solving the Maxwell'00s equation with a great sudden change in the electric conductivity at the particle-fluid interface and then the Maxwell stress tensor is integrated to determine the DEP force exerted on each particle. The fluid flow and particle movement, on the other hand, are predicted by solving the continuity and Navier-Stokes equations together with the kinetic equations. Numerical simulations are carried out using a finite volume approach, composed of a sharp interface method for the electric potential and a direct-forcing immersed-boundary method for the fluid flow. Through the simulations, it is found that both particles with the same sign of the conductivity revolve and eventually align themselves in a line with the electric field. With different signs, to the contrary, they revolve in the reverse way and eventually become lined up at a right angle with the electric field. The DEP motion also depends significantly on the Reynolds number defined based on the external electric field for all the combinations of the conductivity signs. When the Reynolds number is approximately below Re{sub cr} ≈ 0.1, the DEP motion becomes independent of the Reynolds number and thus can be exactly predicted by the no-inertia solver that neglects all the inertial and convective effects. With increasing Reynolds number above the critical number, on the other hand, the particles trace larger trajectories and thus take longer time during their revolution to the eventual in-line alignment.

  17. Study of interaction of fatigue damage and ratcheting. Effect of a tensile primary load on torsion fatigue resistance of stainless steel 304 L at ambient temperature

    International Nuclear Information System (INIS)

    Hakem, N.S.

    1987-01-01

    Effect of ratcheting on fatigue resistance of a stainless steel 304 L, used for reactor vessels, is studied experimentally. Lifetime of samples is reduced if a static constant tensile load (primary loading) is superimposed to cyclic torsion deformations (secondary loading). An equivalent deformation concept is developed to express a criterion of fatigue rupture under primary loading. No effect is noted on the curve of cyclic strain hardening. This fatigue analysis gives no information on cumulated axial deformation. Progressive elongation, observed during testing, is dependent of primary and secondary loading. Rupture is produced by fatigue because cumulated axial deformation is limited ( 4 cycles at rupture cumulated deformation is [fr

  18. Stochastic Ratcheting on a Funneled Energy Landscape Is Necessary for Highly Efficient Contractility of Actomyosin Force Dipoles

    Science.gov (United States)

    Komianos, James E.; Papoian, Garegin A.

    2018-04-01

    Current understanding of how contractility emerges in disordered actomyosin networks of nonmuscle cells is still largely based on the intuition derived from earlier works on muscle contractility. In addition, in disordered networks, passive cross-linkers have been hypothesized to percolate force chains in the network, hence, establishing large-scale connectivity between local contractile clusters. This view, however, largely overlooks the free energy of cross-linker binding at the microscale, which, even in the absence of active fluctuations, provides a thermodynamic drive towards highly overlapping filamentous states. In this work, we use stochastic simulations and mean-field theory to shed light on the dynamics of a single actomyosin force dipole—a pair of antiparallel actin filaments interacting with active myosin II motors and passive cross-linkers. We first show that while passive cross-linking without motor activity can produce significant contraction between a pair of actin filaments, driven by thermodynamic favorability of cross-linker binding, a sharp onset of kinetic arrest exists at large cross-link binding energies, greatly diminishing the effectiveness of this contractility mechanism. Then, when considering an active force dipole containing nonmuscle myosin II, we find that cross-linkers can also serve as a structural ratchet when the motor dissociates stochastically from the actin filaments, resulting in significant force amplification when both molecules are present. Our results provide predictions of how actomyosin force dipoles behave at the molecular level with respect to filament boundary conditions, passive cross-linking, and motor activity, which can explicitly be tested using an optical trapping experiment.

  19. Stochastic Ratcheting on a Funneled Energy Landscape Is Necessary for Highly Efficient Contractility of Actomyosin Force Dipoles

    Directory of Open Access Journals (Sweden)

    James E. Komianos

    2018-04-01

    Full Text Available Current understanding of how contractility emerges in disordered actomyosin networks of nonmuscle cells is still largely based on the intuition derived from earlier works on muscle contractility. In addition, in disordered networks, passive cross-linkers have been hypothesized to percolate force chains in the network, hence, establishing large-scale connectivity between local contractile clusters. This view, however, largely overlooks the free energy of cross-linker binding at the microscale, which, even in the absence of active fluctuations, provides a thermodynamic drive towards highly overlapping filamentous states. In this work, we use stochastic simulations and mean-field theory to shed light on the dynamics of a single actomyosin force dipole—a pair of antiparallel actin filaments interacting with active myosin II motors and passive cross-linkers. We first show that while passive cross-linking without motor activity can produce significant contraction between a pair of actin filaments, driven by thermodynamic favorability of cross-linker binding, a sharp onset of kinetic arrest exists at large cross-link binding energies, greatly diminishing the effectiveness of this contractility mechanism. Then, when considering an active force dipole containing nonmuscle myosin II, we find that cross-linkers can also serve as a structural ratchet when the motor dissociates stochastically from the actin filaments, resulting in significant force amplification when both molecules are present. Our results provide predictions of how actomyosin force dipoles behave at the molecular level with respect to filament boundary conditions, passive cross-linking, and motor activity, which can explicitly be tested using an optical trapping experiment.

  20. Inelastic Cyclic Deformation Behaviors of Type 316H Stainless Steel for Reactor Pressure Vessel of Sodium-Cooled Fast Reactor at Elevated Temperatures

    International Nuclear Information System (INIS)

    Yoon, Ji-Hyun; Hong, Seokmin; Koo, Gyeong-Hoi; Lee, Bong-Sang; Kim, Young-Chun

    2015-01-01

    Type 316H stainless steel is a primary candidate material for a reactor pressure vessel of a sodium-cooled fast (SFR) reactor which is under development in Korea. The reactor pressure vessel for a SFR is subjected to inelastic deformation induced by cyclic thermal stress. Fully reversed cyclic testing and ratcheting testing at elevated temperatures were performed to characterize the inelastic cyclic deformation behaviors of Type 316H stainless steel at the SFR operating temperature. It was found that cyclic hardening of Type 316H stainless steel was enhanced, and the accumulation of ratcheting deformation of Type 316H stainless steel was retarded at around the SFR operating temperature. The results of the tensile testing and the microstructural investigation for dislocated structures after the inelastic deformation testing showed that dynamic strain aging affected the inelastic cyclic deformation behavior of Type 316 stainless steel at around the SFR operating temperature.

  1. Ratchet Transport of Chiral Particles Caused by the Transversal Asymmetry: Current Reversals and Particle Separation

    Science.gov (United States)

    Liu, Jian-li; Lu, Shi-cai; Ai, Bao-quan

    2018-06-01

    Due to the chirality of active particles, the transversal asymmetry can induce the the longitudinal directed transport. The transport of chiral active particles in a periodic channel is investigated in the presence of two types of the transversal asymmetry, the transverse force and the transverse rigid half-circle obstacles. For all cases, the counterclockwise and clockwise particles move to the opposite directions. For the case of the only transverse force, the chiral active particles can reverse their directions when increasing the transverse force. When the transverse rigid half-circle obstacles are introduced, the transport behavior of particles becomes more complex and multiple current reversals occur. The direction of the transport is determined by the competition between two types of the transversal asymmetry. For a given chirality, by suitably tailoring parameters, particles with different self-propulsion speed can move in different directions and can be separated.

  2. Microscopic analysis of the influence of ratcheting on the evolution of dislocation structures observed in AISI 316L stainless steel during low cycle fatigue

    Energy Technology Data Exchange (ETDEWEB)

    Facheris, G., E-mail: giacomo.facheris@psi.ch [Laboratory for Nuclear Materials, Nuclear Energy and Safety Research Department, Paul Scherrer Institute, Villigen PSI (Switzerland); Pham, M.-S. [Department of Materials Science and Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213 (United States); High Temperature Integrity Group, Mechanics for Modelling and Simulation, Swiss Federal Laboratories for Materials Science and Technology, EMPA, Dübendorf (Switzerland); Janssens, K.G.F., E-mail: koen.janssens@psi.ch [Laboratory for Nuclear Materials, Nuclear Energy and Safety Research Department, Paul Scherrer Institute, Villigen PSI (Switzerland); Holdsworth, S.R. [High Temperature Integrity Group, Mechanics for Modelling and Simulation, Swiss Federal Laboratories for Materials Science and Technology, EMPA, Dübendorf (Switzerland)

    2013-12-10

    When subjected to controlled cyclic deformation, the response of austenitic stainless steel typically involves primary hardening followed by softening, and eventually cyclic stabilization with or without secondary hardening. If a continuously drifting mean strain is superposed to an alternating strain path (i.e. strain controlled ratcheting), the response in terms of mean stress and strain amplitude is significantly different. A series of low cycle fatigue and ratcheting experiments are performed at room temperature on round specimens extracted from a batch of AISI 316L hot rolled plate. The experiments are interrupted at cycle numbers selected to correspond with the different strain controlled cycle response stages. The as-received material and the fatigued specimens are analyzed by means of transmission electron microscopy to characterize the microstructure and its evolution with cyclic loading. The low cycle fatigue experiments, performed to establish a reference point for the zero mean strain loading condition, are in line with observations reported for AISI 316L stainless steel by other authors. The continuously increasing mean strain is found to induce higher dislocation densities in the channels of the evolving microstructure, being responsible for the macroscopically observed additional hardening. The observed polarized dislocation walls at least partially accommodate the continuously drifting mean strain and play a role in the non-zero mean stress response.

  3. Biomarker-free dielectrophoretic sorting of differentiating myoblast multipotent progenitor cells and their membrane analysis by Raman spectroscopy.

    Science.gov (United States)

    Muratore, Massimo; Srsen, Vlastimil; Waterfall, Martin; Downes, Andrew; Pethig, Ronald

    2012-09-01

    Myoblasts are muscle derived mesenchymal stem cell progenitors that have great potential for use in regenerative medicine, especially for cardiomyogenesis grafts and intracardiac cell transplantation. To utilise such cells for pre-clinical and clinical applications, and especially for personalized medicine, it is essential to generate a synchronised, homogenous, population of cells that display phenotypic and genotypic homogeneity within a population of cells. We demonstrate that the biomarker-free technique of dielectrophoresis (DEP) can be used to discriminate cells between stages of differentiation in the C2C12 myoblast multipotent mouse model. Terminally differentiated myotubes were separated from C2C12 myoblasts to better than 96% purity, a result validated by flow cytometry and Western blotting. To determine the extent to which cell membrane capacitance, rather than cell size, determined the DEP response of a cell, C2C12 myoblasts were co-cultured with GFP-expressing MRC-5 fibroblasts of comparable size distributions (mean diameter ∼10 μm). A DEP sorting efficiency greater than 98% was achieved for these two cell types, a result concluded to arise from the fibroblasts possessing a larger membrane capacitance than the myoblasts. It is currently assumed that differences in membrane capacitance primarily reflect differences in the extent of folding or surface features of the membrane. However, our finding by Raman spectroscopy that the fibroblast membranes contained a smaller proportion of saturated lipids than those of the myoblasts suggests that the membrane chemistry should also be taken into account.

  4. Dielectrophoretic trapping of multilayer DNA origami nanostructures and DNA origami-induced local destruction of silicon dioxide.

    Science.gov (United States)

    Shen, Boxuan; Linko, Veikko; Dietz, Hendrik; Toppari, J Jussi

    2015-01-01

    DNA origami is a widely used method for fabrication of custom-shaped nanostructures. However, to utilize such structures, one needs to controllably position them on nanoscale. Here we demonstrate how different types of 3D scaffolded multilayer origamis can be accurately anchored to lithographically fabricated nanoelectrodes on a silicon dioxide substrate by DEP. Straight brick-like origami structures, constructed both in square (SQL) and honeycomb lattices, as well as curved "C"-shaped and angular "L"-shaped origamis were trapped with nanoscale precision and single-structure accuracy. We show that the positioning and immobilization of all these structures can be realized with or without thiol-linkers. In general, structural deformations of the origami during the DEP trapping are highly dependent on the shape and the construction of the structure. The SQL brick turned out to be the most robust structure under the high DEP forces, and accordingly, its single-structure trapping yield was also highest. In addition, the electrical conductivity of single immobilized plain brick-like structures was characterized. The electrical measurements revealed that the conductivity is negligible (insulating behavior). However, we observed that the trapping process of the SQL brick equipped with thiol-linkers tended to induce an etched "nanocanyon" in the silicon dioxide substrate. The nanocanyon was formed exactly between the electrodes, that is, at the location of the DEP-trapped origami. The results show that the demonstrated DEP-trapping technique can be readily exploited in assembling and arranging complex multilayered origami geometries. In addition, DNA origamis could be utilized in DEP-assisted deformation of the substrates onto which they are attached. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Experimental observations on uniaxial whole-life transformation ratchetting and low-cycle stress fatigue of super-elastic NiTi shape memory alloy micro-tubes

    Science.gov (United States)

    Song, Di; Kang, Guozheng; Kan, Qianhua; Yu, Chao; Zhang, Chuanzeng

    2015-07-01

    In this work, the low-cycle fatigue failure of super-elastic NiTi shape memory alloy micro-tubes with a wall thickness of 150 μm is investigated by uniaxial stress-controlled cyclic tests at human body temperature 310 K. The effects of mean stress, peak stress, and stress amplitude on the uniaxial whole-life transformation ratchetting and fatigue failure of the NiTi alloy are observed. It is concluded that the fatigue life depends significantly on the stress levels, and the extent of martensite transformation and its reverse play an important role in determining the fatigue life. High peak stress or complete martensite transformation shortens the fatigue life.

  6. Experimental observations on uniaxial whole-life transformation ratchetting and low-cycle stress fatigue of super-elastic NiTi shape memory alloy micro-tubes

    International Nuclear Information System (INIS)

    Song, Di; Kang, Guozheng; Kan, Qianhua; Yu, Chao; Zhang, Chuanzeng

    2015-01-01

    In this work, the low-cycle fatigue failure of super-elastic NiTi shape memory alloy micro-tubes with a wall thickness of 150 μm is investigated by uniaxial stress-controlled cyclic tests at human body temperature 310 K. The effects of mean stress, peak stress, and stress amplitude on the uniaxial whole-life transformation ratchetting and fatigue failure of the NiTi alloy are observed. It is concluded that the fatigue life depends significantly on the stress levels, and the extent of martensite transformation and its reverse play an important role in determining the fatigue life. High peak stress or complete martensite transformation shortens the fatigue life. (paper)

  7. Deformation behaviour of type 316 steel at 400 deg. C

    International Nuclear Information System (INIS)

    Wood, D.S.; Williamson, K.

    A variety of type 316 steel deformation tests at 400 deg. C involving a study of strain rate, stress increment, stress cycling and strain cycling effects are reported. It is concluded that very small ratchet strains may occur, but these are unlikely to be of engineering significance. It is also shown that in the absence of reversed plasticity the upper stress bound is represented by the monotonic stress-strain curve. Under reversed plasticity, significant cyclic hardening can occur and in this case the upper bound may be represented by the cyclic stress-strain curve

  8. Dielectrophoretic separation of gaseous isotopes

    International Nuclear Information System (INIS)

    McConnell, D.B.

    1976-01-01

    This invention relates to a process for the separation of gaseous isotopes by electrophoresis assisted by convective countercurrent flow and to an apparatus for use in the process. The invention is especially applicable to heavy water separation from steam; however, it is to be understood that the invention is broadly applicable to the separation of gaseous isotopes having different dipole moments and/or different molecular weights. (author)

  9. FBR type reactor

    International Nuclear Information System (INIS)

    Jinbo, Masakazu; Kawakami, Hiroto; Nagaoka, Kazuhito.

    1996-01-01

    In a LMFBR type reactor, a liquid level control means is disposed for lowering a level of liquid metal present in an annular gap along with temperature elevation of the liquid metal after the level is once elevated upon start-up of the reactor. In addition, a liquid level measuring means is disposed for measuring the level of the liquid metal present in the annular gap so as to intermittently lower the liquid level. Thus, temperature gradient in the vertical direction of the container can be moderated compared with the case where the liquid level is not changed or the case where temperature is changed together with the elevation of the liquid level. As a result, the change of difference of thermal expansion is decreased to reduce stresses generated in the circumferential direction thereby preventing occurrence of a liquid level heat ratchet phenomenon. Even if the liquid level control means should stop during operation, the liquid level lowers and does not cause a sharp heat gradient as in the case where the liquid level is elevated, and since the temperature of the liquid level is lowered even after shut down of the reactor, generated stresses are not increased. Safety of an intermediate heat exchanger vessel is ensured and observation from a control chamber is enabled. (N.H.)

  10. Scenario analysis of energy saving and CO_2 emissions reduction potentials to ratchet up Japanese mitigation target in 2030 in the residential sector

    International Nuclear Information System (INIS)

    Wakiyama, Takako; Kuramochi, Takeshi

    2017-01-01

    This paper assesses to what extent CO_2 emissions from electricity in the residential sector can be further reduced in Japan beyond its post-2020 mitigation target (known as “Intended Nationally Determined Contribution (INDC)”). The paper examines the reduction potential of electricity demand and CO_2 emissions in the residential sector by conducting a scenario analysis. Electricity consumption scenarios are set up using a time-series regression model, and used to forecast the electricity consumption patterns to 2030. The scenario analysis also includes scenarios that reduce electricity consumption through enhanced energy efficiency and energy saving measures. The obtained results show that Japan can reduce electricity consumption and CO_2 emissions in the residential sector in 2030 more than the Japanese post-2020 mitigation target indicates. At the maximum, the electricity consumption could be reduced by 35 TWh, which contributes to 55.4 MtCO_2 of emissions reduction in 2030 compared to 2013 if the voluntarily targeted CO_2 intensity of electricity is achieved. The result implies that Japan has the potential to ratchet up post-2020 mitigation targets discussed under the Paris Agreement of the United Nations Framework Convention on Climate Change (UNFCCC). - Highlights: • Further reduction of electricity consumption is possible beyond Japan's post-2020 mitigation target. • Energy saving efforts by households and incentives to reduce electricity demands are required. • Improvement of CO_2 intensity from electricity is a key factor in the reduction of CO_2 emissions.

  11. Evaluation of thermal ratchetting on axisymmetric thin shells at the free level of sodium: Experimental results and elastic analysis

    International Nuclear Information System (INIS)

    Cabrillat, M.T.; Gatt, J.M.; Schoulguine, P.; Skiara, A.

    1993-01-01

    Startup operations and load variations for a FBR reactor (Fast Breeder Reactor) cause sodium level variations in the vessels which exert stresses on the emergent shells in the free level area. The loading of these shells is mainly linked to the axial thermal gradient, primary stresses being generally low or negligible as are the radial thermal gradients. Under the effect of these variable axial thermal gradients, there is a risk of progressive deformation even in the absence of primary type stresses. The simplified methods of analysis (Bree diagram, efficiency diagram) proposed in the design codes (Code Case and RCCMR) are not applicable in this specific case where primary type stresses are negligible. In recent years, many studies and experimental programmes have been undertaken in order to propose more reliable methods of analysis for these structures. This paper describes the experimental program, called VINIL, developed at the CEA at Cadarache. After a brief description of the experimental facility and of the experimental results, this paper proposes an evaluation of the risk of progressive deformation on an elastic basis: various simplified methods of analysis were used and are compared with experimental results

  12. Contribution to the validation of thermal ratchetting prevision methods in metallic structures; Contribution a la validation des methodes de prevision du rochet thermique dans les structures metalliques

    Energy Technology Data Exchange (ETDEWEB)

    Rakotovelo, A.M

    1998-03-01

    This work concerns the steady state assessment in the metallic structures subjected to thermomechanical cyclic loadings in biaxial stress state. The effect of the short time mechanical overloads is also investigated. The first chapter is devoted to a bibliographic research concerning the behaviour of the materials and the structures in the cyclic plasticity. Some works relate to the experimental aspect as well as the numerical one for the steady state assessment of such structures are presented. The experimental part of the study is presented in the second chapter. The experimental device was carried out in order to prescribe tension and torsion forces combined with cyclic thermal loading. Some tests was then carried out, among these tests certain include some overloads in tension or torsion. The last chapter describes the numerical calculations using different models (linear isotropic hardening, linear kinematic hardening and elasto-viscoplastic Chaboche's model) and the application of some simplified methods for the ratchetting assessment in the structures. We have considered two categories of methods. The first one is based on an elastic analysis (Bree's diagram, 3 Sm rule, efficiency rule) and the second one combines elastic analysis and elastoplastic analysis of the first cycle (Gatt's and Taleb's methods). The results of this study have enabled: to validate in the biaxial stress state an expression which takes into account the effect of mechanical short time overloads; to test the performances of considered models to describe the evolution of the structure during the first cycle and to take into account the effect of short time overloads. Among the considered models, the elastoplastic Chaboche's model seems to be the most accurate to describe the structure's behaviour during the first cycles; to validate some simplified methods. Certain methods based only on elastic analysis (Bee's diagram and efficiency rule) seem not

  13. Deterministic ratchets for suspension fractionation

    NARCIS (Netherlands)

    Kulrattanarak, T.

    2010-01-01

    Driven by the current insights in sustainability and technological development in
    biorefining natural renewable resources, the food industry has taken an interest in
    fractionation of agrofood materials, like milk and cereal crops. The purpose of fractionation
    is to split the raw

  14. “土地财政”内在生成逻辑、棘轮效应与自主债融资架构%The Inherent Logic, Ratchet Effect and Independent Debt Financing Structure of "Land finance"

    Institute of Scientific and Technical Information of China (English)

    夏梁省

    2012-01-01

    伴随分税制改革,在财政扩张的驱使下,“土地财政”发展成为地方政府财政资金的重要来源。但是,“土地财政”内在的棘轮效应带来一系列发展问题,具有不可持续性,并倒逼地方政府减少对“土地财政”的依赖程度,寻求融资机制的创新。财政部试行的地方政府自行发债举措,为地方政府未来的融资方式创新提供了方向性导引,地方政府应该在自主债融资框架下积极探索新的融资机制,改善财政资金的结构比例。%With the reform of tax system, "Land finance" had become an important fund source of local govern- ments driven by fiscal expansion. But, the internal ratchet effects of "Land finance" has brought a series of problems in the development, which are unsustainable, and force the local governments to reduce the dependence on "land fi- nance" through innovations of financing mechanisms. The trial of Ministry of Finance that the local governments can initiate treasury bonds on their own provides a directional guidance for the future financing innovation of local govern- ments. Local governments should positively explore new financing mechanisms in the framework of self-debt finan- cing, to improve the mix of financial resources.

  15. Identifying functional thermodynamics in autonomous Maxwellian ratchets

    Science.gov (United States)

    Boyd, Alexander B.; Mandal, Dibyendu; Crutchfield, James P.

    2016-02-01

    We introduce a family of Maxwellian Demons for which correlations among information bearing degrees of freedom can be calculated exactly and in compact analytical form. This allows one to precisely determine Demon functional thermodynamic operating regimes, when previous methods either misclassify or simply fail due to approximations they invoke. This reveals that these Demons are more functional than previous candidates. They too behave either as engines, lifting a mass against gravity by extracting energy from a single heat reservoir, or as Landauer erasers, consuming external work to remove information from a sequence of binary symbols by decreasing their individual uncertainty. Going beyond these, our Demon exhibits a new functionality that erases bits not by simply decreasing individual-symbol uncertainty, but by increasing inter-bit correlations (that is, by adding temporal order) while increasing single-symbol uncertainty. In all cases, but especially in the new erasure regime, exactly accounting for informational correlations leads to tight bounds on Demon performance, expressed as a refined Second Law of thermodynamics that relies on the Kolmogorov-Sinai entropy for dynamical processes and not on changes purely in system configurational entropy, as previously employed. We rigorously derive the refined Second Law under minimal assumptions and so it applies quite broadly—for Demons with and without memory and input sequences that are correlated or not. We note that general Maxwellian Demons readily violate previously proposed, alternative such bounds, while the current bound still holds. As such, it broadly describes the minimal energetic cost of any computation by a thermodynamic system.

  16. Ratcheting Up The Search for Dark Matter

    Energy Technology Data Exchange (ETDEWEB)

    McDermott, Samuel Dylan [Univ. of Michigan, Ann Arbor, MI (United States)

    2014-01-01

    The last several years have included remarkable advances in two of the primary areas of fundamental particle physics: the search for dark matter and the discovery of the Higgs boson. This dissertation will highlight some contributions made on the forefront of these exciting fields. Although the circumstantial evidence supporting the dark matter hypothesis is now almost undeniably significant, indisputable direct proof is still lacking. As the direct searches for dark matter continue, we can maximize our prospects of discovery by using theoretical techniques complementary to the observational searches to rule out additional, otherwise accessible parameter space. In this dissertation, I report bounds on a wide range of dark matter theories. The models considered here cover the spectrum from the canonical case of self-conjugate dark matter with weak-scale interactions, to electrically charged dark matter, to non-annihilating, non-fermionic dark matter. These bounds are obtained from considerations of astrophysical and cosmological data, including, respectively: diffuse gamma ray photon observations; structure formation considerations, along with an explication of the novel local dark matter structure due to galactic astrophysics; and the existence of old pulsars in dark-matter-rich environments. I also consider the prospects for a model of neutrino dark matter which has been motivated by a wide set of seemingly contradictory experimental results. In addition, I include a study that provides the tools to begin solving the speculative ``inverse'' problem of extracting dark matter properties solely from hypothetical nuclear energy spectra, which we may face if dark matter is discovered with multiple direct detection experiments. In contrast to the null searches for dark matter, we have the example of the recent discovery of the Higgs boson. The Higgs boson is the first fundamental scalar particle ever observed, and precision measurements of the production and decay of the Higgs boson represent a unique entry p! oint to searches for new kinds of physics. Continuing to refine our understanding of the Higgs boson will also allow us to learn about a vast array of possible new physics. This dissertation includes work parameterizing some of the scenarios that are most likely to be discovered with future Higgs data.

  17. Blood typing

    Science.gov (United States)

    ... detect these minor antigens. It is done before transfusions, except in emergency situations. Alternative Names Cross matching; Rh typing; ABO blood typing; Blood group; Anemia - immune hemolytic blood type; ...

  18. Klebsiella Typing

    DEFF Research Database (Denmark)

    Hansen, D S; Skov, R; Benedí, J.V.

    2002-01-01

    OBJECTIVE: To compare pulsed-field gel electrophoresis (PFGE) typing and O:K-serotyping of Klebsiella in two different epidemiological settings. METHODS: One hundred and four bacteremia isolates without known epidemiological relation and 47 isolates from an outbreak in a neonatal intensive care...... unit (NICU) were K-typed by countercurrent immunoelectrophoresis (CCIE), O-typed by an inhibition enzyme-linked immunosorbent assay method, and typed by pulsed-field gel electrophoresis (PFGE) using the restriction enzyme XbaI. RESULTS: Typing data for the 104 bacteremia isolates were compared...... with regard to typability, number of types, maximum number of isolates per type, and the Discriminative Index (DI). O-typing combined with K-typing (DI 0.98) as O:K-serotyping (DI 0.99) gave a very discriminative typing system, whereas O-typing alone was not very discriminative (DI 0.76). PFGE (DI 1...

  19. Blood Types

    Science.gov (United States)

    ... blood, safe blood transfusions depend on careful blood typing and cross-matching. There are four major blood ... cause exceptions to the above patterns. ABO blood typing is not sufficient to prove or disprove paternity ...

  20. Graphene-edge dielectrophoretic tweezers for trapping of biomolecules.

    Science.gov (United States)

    Barik, Avijit; Zhang, Yao; Grassi, Roberto; Nadappuram, Binoy Paulose; Edel, Joshua B; Low, Tony; Koester, Steven J; Oh, Sang-Hyun

    2017-11-30

    The many unique properties of graphene, such as the tunable optical, electrical, and plasmonic response make it ideally suited for applications such as biosensing. As with other surface-based biosensors, however, the performance is limited by the diffusive transport of target molecules to the surface. Here we show that atomically sharp edges of monolayer graphene can generate singular electrical field gradients for trapping biomolecules via dielectrophoresis. Graphene-edge dielectrophoresis pushes the physical limit of gradient-force-based trapping by creating atomically sharp tweezers. We have fabricated locally backgated devices with an 8-nm-thick HfO 2 dielectric layer and chemical-vapor-deposited graphene to generate 10× higher gradient forces as compared to metal electrodes. We further demonstrate near-100% position-controlled particle trapping at voltages as low as 0.45 V with nanodiamonds, nanobeads, and DNA from bulk solution within seconds. This trapping scheme can be seamlessly integrated with sensors utilizing graphene as well as other two-dimensional materials.

  1. Dielectrophoretic immobilisation of nanoparticles as isolated singles in regular arrays

    Science.gov (United States)

    Knigge, Xenia; Wenger, Christian; Bier, Frank F.; Hölzel, Ralph

    2018-02-01

    We demonstrate the immobilisation of polystyrene nanoparticles on vertical nano-electrodes by means of dielectrophoresis. The electrodes have diameters of 500 nm or 50 nm, respectively, and are arranged in arrays of several thousand electrodes, allowing many thousands of experiments in parallel. At a frequency of 15 kHz, which is found favourable for polystyrene, several occupation patterns are observed, and both temporary and permanent immobilisation is achieved. In addition, a histogram method is applied, which allows to determine the number of particles occupying the electrodes. These results are validated with scanning electron microscopy images. Immobilising exactly one particle at each electrode tip is achieved for electrode tip diameters with half the particle size. Extension of this system down to the level of single molecules is envisaged, which will avoid ensemble averaging at still statistically large sample sizes.

  2. TEMPLATE-ASSISTED FABRICATION AND DIELECTROPHORETIC MANIPULATION OF PZT MICROTUBES

    Directory of Open Access Journals (Sweden)

    VLADIMÍR KOVAĽ

    2012-09-01

    Full Text Available Mesoscopic high aspect ratio ferroelectric tube structures of a diverse range of compositions with tailored physical properties can be used as key components in miniaturized flexible electronics, nano- and micro-electro-mechanical systems, nonvolatile FeRAM memories, and tunable photonic applications. They are usually produced through advanced “bottom-up” or “topdown” fabrication techniques. In this study, a template wetting approach is employed for fabrication of Pb(Zr0.52Ti0.48O3 (PZT microtubes. The method is based on repeated infiltration of precursor solution into macroporous silicon (Si templates at a sub-atmospheric pressure. Prior to crystallization at 750°C, free-standing tubes of a 2-μm outer diameter, extending to over 30 μm in length were released from the Si template using a selective isotropic-pulsed XeF2 reactive ion etching. To facilitate rapid electrical characterization and enable future integration process, directed positioning and aligning of the PZT tubes was performed by dielectrophoresis. The electric field-assisted technique involves an alternating electric voltage that is applied through pre-patterned microelectrodes to a colloidal suspension of PZT tubes dispersed in isopropyl alcohol. The most efficient biasing for the assembly of tubes across the electrode gap of 12 μm was a square wave signal of 5 Vrms and 10 Hz. By varying the applied frequency in between 1 and 10 Hz, an enhancement in tube alignment was obtained.

  3. High Voltage Dielectrophoretic and Magnetophoretic Hybrid Integrated Circuit / Microfluidic Chip

    Science.gov (United States)

    Issadore, David; Franke, Thomas; Brown, Keith A.; Hunt, Thomas P.; Westervelt, Robert M.

    2010-01-01

    A hybrid integrated circuit (IC) / microfluidic chip is presented that independently and simultaneously traps and moves microscopic objects suspended in fluid using both electric and magnetic fields. This hybrid chip controls the location of dielectric objects, such as living cells and drops of fluid, on a 60 × 61 array of pixels that are 30 × 38 μm2 in size, each of which can be individually addressed with a 50 V peak-to-peak, DC to 10 MHz radio frequency voltage. These high voltage pixels produce electric fields above the chip’s surface with a magnitude , resulting in strong dielectrophoresis (DEP) forces . Underneath the array of DEP pixels there is a magnetic matrix that consists of two perpendicular sets of 60 metal wires running across the chip. Each wire can be sourced with 120 mA to trap and move magnetically susceptible objects using magnetophoresis (MP). The DEP pixel array and magnetic matrix can be used simultaneously to apply forces to microscopic objects, such as living cells or lipid vesicles, that are tagged with magnetic nanoparticles. The capabilities of the hybrid IC / microfluidic chip demonstrated in this paper provide important building blocks for a platform for biological and chemical applications. PMID:20625468

  4. Compact and tunable size-based dielectrophoretic flow fractionation

    International Nuclear Information System (INIS)

    Chuang, Han-Sheng; Chung, Tien-Yu; Li, Yun

    2014-01-01

    A compact and tunable size-based flow fractionation microchip using negative dielectrophoresis (DEP) is presented in this paper. In the microchip, a sample containing a mixture of particles is hydrodynamically focused in a contraction section and then sorted by size after flowing over planar interdigitated electrodes. The electrodes and flow chamber were aligned at an angle of 45° to produce effective sorting. 1, 2.5 and 4.8 µm polystyrene (PS) particles were successfully separated into three distinct streams in a short distance (1 mm) and collected in different outlet channels. The sorting was subjected to flow rates and electric potential. The experimental sorting efficiencies of 1, 2.5 and 4.8 µm particles reached 97.2%, 79.6% and 99.8%, respectively. With the same device, lipid vesicle sorting was demonstrated. 86.9% of vesicles larger than 10 µm were effectively extracted from the sample stream. Likewise, sorting of other biological particles can be achieved in the same fashion. (paper)

  5. Type Tricks

    DEFF Research Database (Denmark)

    Beier, Sofie

    2017-01-01

    Type Tricks’ is about typographical rules and the underlying structure of the work process in the design of new typefaces. In that way, it is both a reference book and a user manual. In an illustrative format, it presents the different stages of type design in an easily accessible manner. Being...

  6. Type inference for correspondence types

    DEFF Research Database (Denmark)

    Hüttel, Hans; Gordon, Andy; Hansen, Rene Rydhof

    2009-01-01

    We present a correspondence type/effect system for authenticity in a π-calculus with polarized channels, dependent pair types and effect terms and show how one may, given a process P and an a priori type environment E, generate constraints that are formulae in the Alternating Least Fixed......-Point (ALFP) logic. We then show how a reasonable model of the generated constraints yields a type/effect assignment such that P becomes well-typed with respect to E if and only if this is possible. The formulae generated satisfy a finite model property; a system of constraints is satisfiable if and only...... if it has a finite model. As a consequence, we obtain the result that type/effect inference in our system is polynomial-time decidable....

  7. Blood Types

    Science.gov (United States)

    ... positive or Rh-negative blood may be given to Rh-positive patients. The rules for plasma are the reverse: ... ethnic and racial groups have different frequency of the main blood types in their populations. Approximately ...

  8. Tank type LMFBR type reactors

    International Nuclear Information System (INIS)

    Shimizu, Hiroshi

    1985-01-01

    Purpose: To detect the abnormality in the suspended body or reactor core supporting structures thereby improve the safety and reliability of tank type LMFBR reactors. Constitution: Upon inspection during reactor operation period, the top end of the gripper sensing rod of a fuel exchanger is abutted against a supporting bed and the position of the reactor core supporting structures from the roof slab is measured by a stroke measuring device. Then, the sensing rod is pulled upwardly to abut against the arm portion and the position is measured by the stroke measuring device. The measuring procedures are carried out for all of the sensing rods and the measured values are compared with a previously determined value at the initial stage of the reactor operation. As a result, it is possible to detect excess distortions and abnormal deformation in the suspended body or reactor core supporting structures. Furthermore, integrity of the suspended body against thermal stresses can be secured by always measuring the coolant liquid level by the level measuring sensor. (Kamimura, M.)

  9. Type Classes for Lightweight Substructural Types

    Directory of Open Access Journals (Sweden)

    Edward Gan

    2015-02-01

    Full Text Available Linear and substructural types are powerful tools, but adding them to standard functional programming languages often means introducing extra annotations and typing machinery. We propose a lightweight substructural type system design that recasts the structural rules of weakening and contraction as type classes; we demonstrate this design in a prototype language, Clamp. Clamp supports polymorphic substructural types as well as an expressive system of mutable references. At the same time, it adds little additional overhead to a standard Damas-Hindley-Milner type system enriched with type classes. We have established type safety for the core model and implemented a type checker with type inference in Haskell.

  10. Refining types using type guards in TypeScript

    NARCIS (Netherlands)

    de Wolff, Ivo Gabe; Hage, J.

    2017-01-01

    We discuss two adaptations of the implementation of type guards and narrowing in the TypeScript compiler. The first is an improvement on the original syntax-directed implementation, and has now replaced the original one in the TypeScript compiler. It is specifically suited for the scenario in which

  11. Guarded dependent type theory with coinductive types

    DEFF Research Database (Denmark)

    Bizjak, Aleš; Grathwohl, Hans Bugge; Clouston, Ranald

    2016-01-01

    We present guarded dependent type theory, gDTT, an extensional dependent type theory with a later' modality and clock quantifiers for programming and proving with guarded recursive and coinductive types. The later modality is used to ensure the productivity of recursive definitions in a modular......, type based, way. Clock quantifiers are used for controlled elimination of the later modality and for encoding coinductive types using guarded recursive types. Key to the development of gDTT are novel type and term formers involving what we call delayed substitutions’. These generalise the applicative...... functor rules for the later modality considered in earlier work, and are crucial for programming and proving with dependent types. We show soundness of the type theory with respect to a denotational model....

  12. Facts about Type 2

    Medline Plus

    Full Text Available ... Care of Type 2 Diabetes This two-page introduction to type 2 diabetes is in PDF format ... Basics Symptoms Type 1 Type 2 Gestational Myths Statistics Common Terms Genetics Living With Diabetes Recently Diagnosed ...

  13. Refinement Types for TypeScript

    OpenAIRE

    Vekris, Panagiotis; Cosman, Benjamin; Jhala, Ranjit

    2016-01-01

    We present Refined TypeScript (RSC), a lightweight refinement type system for TypeScript, that enables static verification of higher-order, imperative programs. We develop a formal core of RSC that delineates the interaction between refinement types and mutability. Next, we extend the core to account for the imperative and dynamic features of TypeScript. Finally, we evaluate RSC on a set of real world benchmarks, including parts of the Octane benchmarks, D3, Transducers, and the TypeScript co...

  14. Facts about Type 2

    Medline Plus

    Full Text Available ... Alert Day Diabetes Basics Home Symptoms Diagnosis America's Diabetes Challenge Type 1 Type 2 Facts About Type 2 Enroll in ... Where Do I Begin With Type2? Living With Type 1 Diabetes Enroll in the Living WIth Type 2 Diabetes ...

  15. Omnidirectional Transport in Fully Reconfigurable Two Dimensional Optical Ratchets

    Czech Academy of Sciences Publication Activity Database

    Arzola, A. V.; Villasante-Barahona, M.; Volke-Sepulveda, K.; Jákl, Petr; Zemánek, Pavel

    2017-01-01

    Roč. 118, č. 13 (2017), s. 1-5, č. článku 138002. ISSN 0031-9007 R&D Projects: GA ČR GB14-36681G; GA MŠk(CZ) LO1212; GA MŠk(CZ) LD14069 Institutional support: RVO:68081731 Keywords : separation * motion Subject RIV: BH - Optics, Masers, Lasers OBOR OECD: Optics (including laser optics and quantum optics) Impact factor: 8.462, year: 2016

  16. Experimental adiabatic vortex ratchet effect in Nb films with ...

    Indian Academy of Sciences (India)

    tuned at will with the value of the applied magnetic field. Acknowledgments. We want to thank Spanish Ministerio de Educacion y Ciencia for grants MAT2002-. 04543 and MAT2002-12385-E and CAM GR/MAT/0617/2004. E M Gonzalez and. N O Nunez want to thank Spanish Ministerio de Educacion y Ciencia for ramon y.

  17. Forespore Engulfment Mediated by a Ratchet-Like Mechanism

    OpenAIRE

    Broder, Dan H.; Pogliano, Kit

    2006-01-01

    A key step in bacterial endospore formation is engulfment, during which one bacterial cell engulfs another in a phagocytosis-like process that normally requires SpoIID, SpoIIM, and SpoIIP (DMP). We here describe a second mechanism involving the zipper-like interaction between the forespore protein SpoIIQ and its mother cell ligand SpoIIIAH, which are essential for engulfment when DMP activity is reduced or SpoIIB is absent. They are also required for the rapid engulfment observed during the e...

  18. Transport in ratchets with single-file constraint

    Indian Academy of Sciences (India)

    file diffusion” in the literature. Anomaly in protein molecule diffusion on a cell ... tic media [20]. The rectification effect vanishes in the adiabatically slow modulation limit and optimizes in a driving frequency range. In other related work on flash-.

  19. Multiaxial ratcheting with advanced kinematic and directional distortional hardening rules

    Czech Academy of Sciences Publication Activity Database

    Feigenbaum, H. P.; Dugdale, J.; Dafalias, Y.F.; Kourousis, K. I.; Plešek, Jiří

    2012-01-01

    Roč. 49, č. 22 (2012), s. 3063-3076 ISSN 0020-7683 R&D Projects: GA MŠk(CZ) ME10024 Institutional research plan: CEZ:AV0Z20760514 Keywords : plasticity * directional distortional hardening * thermodynamics Subject RIV: JJ - Other Materials Impact factor: 1.871, year: 2012 http://www.sciencedirect.com/science/article/pii/S0020768312002612

  20. Spatial propagation of excitonic coherence enables ratcheted energy transfer

    OpenAIRE

    Hoyer, Stephan; Ishizaki, Akihito; Whaley, K. Birgitta

    2011-01-01

    Experimental evidence shows that a variety of photosynthetic systems can preserve quantum beats in the process of electronic energy transfer, even at room temperature. However, whether this quantum coherence arises in vivo and whether it has any biological function have remained unclear. Here we present a theoretical model that suggests that the creation and recreation of coherence under natural conditions is ubiquitous. Our model allows us to theoretically demonstrate a mechanism for a ratch...

  1. Ratcheting tests on stainless steel 316 L at room temperature

    International Nuclear Information System (INIS)

    Cousseran, Pierre; Lebey, Jacques; Roche, Roland; Corbel, P.

    1980-06-01

    An experimental study on progressive distortion (tension-torsion) of simple structures (thin tubes) has been undertaken at the CEA. Results of tests performed on 316 L steel at room temperature are reported in this paper. There are chiefly: - plastic iso-deformation curves in the field of the 2 loadings applied to the specimen, i.e. the constant primary loading P (tension) and the secondary loading ΔQ (cyclic torsion at controled deformation); - indications on the evolution of torque and of torsion plastic deformation, during the cycling; - a convenient rule for evaluation of the progressive distortion is proposed. It is based on the use of an effective stress Psub(eff), which is determined from the tensile characteristics of the material, of when creep occurs, from creep curves [fr

  2. Types of Dementia

    Science.gov (United States)

    ... Kids For Teens For Parents & Teachers Resolving Family Conflicts The Holidays and Alzheimer's Glossary Virtual Library Online ... Use Map Selector Search Alzheimer’s Association Alzheimer's & Dementia Types of Dementia Types of Dementia Types of Dementia ...

  3. Type 1 diabetes

    Science.gov (United States)

    Insulin-dependent diabetes; Juvenile onset diabetes; Diabetes - type 1; High blood sugar - type 1 diabetes ... Type 1 diabetes can occur at any age. It is most often diagnosed in children, adolescents, or young adults. Insulin is ...

  4. Types of Diabetes

    Science.gov (United States)

    ... Diabetes, Sexual, & Bladder Problems Clinical Trials What is Diabetes? Diabetes is a disease that occurs when your ... is serious. What are the different types of diabetes? The most common types of diabetes are type ...

  5. Facts about Type 2

    Medline Plus

    Full Text Available ... Day Diabetes Basics Home Symptoms Diagnosis America's Diabetes Challenge Type 1 Type 2 Facts About Type 2 ... Planner, and tips from experts Let's Be Well: Products to help you thrive with diabetes - lets-be- ...

  6. Type 2 diabetes

    Science.gov (United States)

    ... type 2 diabetes; Oral hypoglycemic - type 2 diabetes; High blood sugar - type 2 diabetes ... your kidneys are working well ( microalbuminuria and serum creatinine ). Visit your eye doctor at least once a ...

  7. Facts about Type 2

    Medline Plus

    Full Text Available ... En Español Type 1 Type 2 About Us Online Community Meal Planning Sign In Search: Search More ... Diagnosing Diabetes and Learning About Prediabetes Type 2 Diabetes Risk Test Lower ...

  8. Guarded Cubical Type Theory

    DEFF Research Database (Denmark)

    Birkedal, Lars; Bizjak, Aleš; Clouston, Ranald

    2016-01-01

    This paper improves the treatment of equality in guarded dependent type theory (GDTT), by combining it with cubical type theory (CTT). GDTT is an extensional type theory with guarded recursive types, which are useful for building models of program logics, and for programming and reasoning...... with coinductive types. We wish to implement GDTT with decidable type-checking, while still supporting non-trivial equality proofs that reason about the extensions of guarded recursive constructions. CTT is a variation of Martin-L\\"of type theory in which the identity type is replaced by abstract paths between...... terms. CTT provides a computational interpretation of functional extensionality, is conjectured to have decidable type checking, and has an implemented type-checker. Our new type theory, called guarded cubical type theory, provides a computational interpretation of extensionality for guarded recursive...

  9. Facts about Type 2

    Medline Plus

    Full Text Available ... Do I Begin With Type2? Living With Type 1 Diabetes Enroll in the Living WIth Type 2 Diabetes Program In It Together We Can Help ... Tips for Caregivers Health Insurance Health Insurance ...

  10. Types of Blood Donations

    Science.gov (United States)

    ... Red Cell Plasma Platelets Red Cells What blood donation type is best for me? **If you do ... type, a whole blood donation is recommended** Blood Donation Types: Volunteer Donations The standard or most common ...

  11. Facts about Type 2

    Medline Plus

    Full Text Available ... a Member Donate Now! One Time Monthly In Memory In Honor Become a Member En Español Type 1 Type ... Diagnosing Diabetes and Learning About Prediabetes Type 2 Diabetes Risk Test Lower ...

  12. Guarded Cubical Type Theory

    DEFF Research Database (Denmark)

    Birkedal, Lars; Bizjak, Aleš; Clouston, Ranald

    2016-01-01

    This paper improves the treatment of equality in guarded dependent type theory (GDTT), by combining it with cubical type theory (CTT). GDTT is an extensional type theory with guarded recursive types, which are useful for building models of program logics, and for programming and reasoning...... with coinductive types. We wish to implement GDTT with decidable type checking, while still supporting non-trivial equality proofs that reason about the extensions of guarded recursive constructions. CTT is a variation of Martin-L\\"of type theory in which the identity type is replaced by abstract paths between...... terms. CTT provides a computational interpretation of functional extensionality, enjoys canonicity for the natural numbers type, and is conjectured to support decidable type-checking. Our new type theory, guarded cubical type theory (GCTT), provides a computational interpretation of extensionality...

  13. Facts about Type 2

    Medline Plus

    Full Text Available ... August 1, 2013 Last Edited: October 27, 2015 Articles from Diabetes Forecast® magazine: lp-type-2, . In this section Diabetes Basics Type 2 Facts About Type 2 Recently Diagnosed Treatment and Care Blood ...

  14. Facts about Type 2

    Medline Plus

    Full Text Available ... Ways to Give Close Are You at Risk? Home Prevention Diagnosing Diabetes and Learning About Prediabetes Type ... To Know Your Risk Alert Day Diabetes Basics Home Symptoms Diagnosis America's Diabetes Challenge Type 1 Type ...

  15. Type classes for mathematics in type theory

    OpenAIRE

    Spitters, Bas; Van der Weegen, Eelis

    2011-01-01

    The introduction of first-class type classes in the Coq system calls for re-examination of the basic interfaces used for mathematical formalization in type theory. We present a new set of type classes for mathematics and take full advantage of their unique features to make practical a particularly flexible approach formerly thought infeasible. Thus, we address both traditional proof engineering challenges as well as new ones resulting from our ambition to build upon this development a library...

  16. Concrete Types for TypeScript

    OpenAIRE

    Richards, Gregor; Zappa Nardelli, Francesco; Vitek, Jan

    2015-01-01

    Typescript extends JavaScript with optional type annotations that are, by design, unsound and, that the Typescript compiler discards as it emits code. This design point preserves programming idioms developers are familiar with, and allows them to leave their legacy code unchanged, while offering a measure of static error checking in parts of the program that have type annotations. We present an alternative design for TypeScript, one where it is possible to support the same degree of dynamism,...

  17. Several types of types in programming languages

    OpenAIRE

    Martini, Simone

    2015-01-01

    Part 2: Regular Submissions; International audience; Types are an important part of any modern programming language, but we often forget that the concept of type we understand nowadays is not the same it was perceived in the sixties. Moreover, we conflate the concept of " type " in programming languages with the concept of the same name in mathematical logic, an identification that is only the result of the convergence of two different paths, which started apart with different aims. The paper...

  18. Facts about Type 2

    Medline Plus

    Full Text Available ... Know Your Risk Diabetes Basics Symptoms Type 1 Type 2 Gestational Myths Statistics Common Terms Genetics Living With Diabetes Recently Diagnosed Treatment & Care Complications ...

  19. Types and Automata

    DEFF Research Database (Denmark)

    Schwartzbach, Michael Ignatieff; Meineche Smidt, Erik

    A hierarchical type system for imperative programming languages gives rise to various computational problems, such as type equivalence, type ordering, etc. We present a particular class of finite automata which are shown to be isomorphic to type equations. All the relevant type concepts turn out...... to have well-known automata analogues, such as language equality, language inclusion, etc. This provides optimal or best known algorithms for the type system, by a process of translating type equations to automata, solving the analogous problem, and translating the result back to type equations. Apart...

  20. Type checking with open type functions

    DEFF Research Database (Denmark)

    Schrijvers, Tom; Jones, Simon Peyton; Chakravarty, Manual

    2008-01-01

    We report on an extension of Haskell with open type-level functions and equality constraints that unifies earlier work on GADTs, functional dependencies, and associated types. The contribution of the paper is that we identify and characterise the key technical challenge of entailment checking; an...

  1. Equational type logic

    NARCIS (Netherlands)

    Manca, V.; Salibra, A.; Scollo, Giuseppe

    1990-01-01

    Equational type logic is an extension of (conditional) equational logic, that enables one to deal in a single, unified framework with diverse phenomena such as partiality, type polymorphism and dependent types. In this logic, terms may denote types as well as elements, and atomic formulae are either

  2. Types of intersections.

    NARCIS (Netherlands)

    2015-01-01

    There are many types of intersections in the Netherlands. In an inherently safe road traffic system, however, the number of intersection types needs to be limited, depending on the road types that intersect. The desired types of intersections do not always correspond with the recommendations in the

  3. On use of radial evanescence remain term in kinematic hardening

    International Nuclear Information System (INIS)

    Geyer, P.

    1995-01-01

    This paper presents the interest which lies in non-linear kinematic hardening rule with radial evanescence remain term as proposed for modelling multiaxial ratchetting. From analytical calculations in the case of the tension/torsion test, this ratchetting is compared with that proposed by Armstrong and Frederick. A modification is then proposed for Chaboche's elastoplastic model with two non-linear kinematic variables, by coupling the two types of hardening by means of two scalar parameters. Identification of these two parameters returns to speculate on the directions of strain in order to adjust the ratchetting to experimental observations. Using biaxial ratchetting tests on stainless steel 316 L specimens at ambient temperature, it is shown that satisfactory modelling of multiaxial ratchetting is obtained. (author). 4 refs., 5 figs

  4. Type Inference with Inequalities

    DEFF Research Database (Denmark)

    Schwartzbach, Michael Ignatieff

    1991-01-01

    of (monotonic) inequalities on the types of variables and expressions. A general result about systems of inequalities over semilattices yields a solvable form. We distinguish between deciding typability (the existence of solutions) and type inference (the computation of a minimal solution). In our case, both......Type inference can be phrased as constraint-solving over types. We consider an implicitly typed language equipped with recursive types, multiple inheritance, 1st order parametric polymorphism, and assignments. Type correctness is expressed as satisfiability of a possibly infinite collection...

  5. Towards Practical Gradual Typing

    OpenAIRE

    Takikawa, Asumu; Feltey, Daniel; Dean, Earl; Flatt, Matthew; Findler, Robert Bruce; Tobin-Hochstadt, Sam; Felleisen, Matthias

    2015-01-01

    Over the past 20 years, programmers have embraced dynamically-typed programming languages. By now, they have also come to realize that programs in these languages lack reliable type information for software engineering purposes. Gradual typing addresses this problem; it empowers programmers to annotate an existing system with sound type information on a piecemeal basis. This paper presents an implementation of a gradual type system for a full-featured class-based language as well as a novel p...

  6. Multiparty Asynchronous Session Types

    DEFF Research Database (Denmark)

    Honda, Kohei; Yoshida, Nobuko; Carbone, Marco

    2016-01-01

    . This work extends the foregoing theories of binary session types to multiparty, asynchronous sessions, which often arise in practical communication-centered applications. Presented as a typed calculus for mobile processes, the theory introduces a new notion of types in which interactions involving multiple......Communication is a central elements in software development. As a potential typed foundation for structured communication-centered programming, session types have been studied over the past decade for a wide range of process calculi and programming languages, focusing on binary (two-party) sessions...... peers are directly abstracted as a global scenario. Global types retain the friendly type syntax of binary session types while specifying dependencies and capturing complex causal chains of multiparty asynchronous interactions. A global type plays the role of a shared agreement among communication peers...

  7. Multiparty symmetric sum types

    DEFF Research Database (Denmark)

    Nielsen, Lasse; Yoshida, Nobuko; Honda, Kohei

    2010-01-01

    This paper introduces a new theory of multiparty session types based on symmetric sum types, by which we can type non-deterministic orchestration choice behaviours. While the original branching type in session types can represent a choice made by a single participant and accepted by others...... determining how the session proceeds, the symmetric sum type represents a choice made by agreement among all the participants of a session. Such behaviour can be found in many practical systems, including collaborative workflow in healthcare systems for clinical practice guidelines (CPGs). Processes...... with the symmetric sums can be embedded into the original branching types using conductor processes. We show that this type-driven embedding preserves typability, satisfies semantic soundness and completeness, and meets the encodability criteria adapted to the typed setting. The theory leads to an efficient...

  8. Advances in Blood Typing.

    Science.gov (United States)

    Quraishy, N; Sapatnekar, S

    The clinical importance of blood group antigens relates to their ability to evoke immune antibodies that are capable of causing hemolysis. The most important antigens for safe transfusion are ABO and D (Rh), and typing for these antigens is routinely performed for patients awaiting transfusion, prenatal patients, and blood donors. Typing for other blood group antigens, typically of the Kell, Duffy, Kidd, and MNS blood groups, is sometimes necessary, for patients who have, or are likely to develop antibodies to these antigens. The most commonly used typing method is serological typing, based on hemagglutination reactions against specific antisera. This method is generally reliable and practical for routine use, but it has certain drawbacks. In recent years, molecular typing has emerged as an alternative or supplemental typing method. It is based on detecting the polymorphisms and mutations that control the expression of blood group antigens, and using this information to predict the probable antigen type. Molecular typing methods are useful when traditional serological typing methods cannot be used, as when a patient has been transfused and the sample is contaminated with red blood cells from the transfused blood component. Moreover, molecular typing methods can precisely identify clinically significant variant antigens that cannot be distinguished by serological typing; this capability has been exploited for the resolution of typing discrepancies and shows promise for the improved transfusion management of patients with sickle cell anemia. Despite its advantages, molecular typing has certain limitations, and it should be used in conjunction with serological methods. © 2016 Elsevier Inc. All rights reserved.

  9. Linearly Refined Session Types

    Directory of Open Access Journals (Sweden)

    Pedro Baltazar

    2012-11-01

    Full Text Available Session types capture precise protocol structure in concurrent programming, but do not specify properties of the exchanged values beyond their basic type. Refinement types are a form of dependent types that can address this limitation, combining types with logical formulae that may refer to program values and can constrain types using arbitrary predicates. We present a pi calculus with assume and assert operations, typed using a session discipline that incorporates refinement formulae written in a fragment of Multiplicative Linear Logic. Our original combination of session and refinement types, together with the well established benefits of linearity, allows very fine-grained specifications of communication protocols in which refinement formulae are treated as logical resources rather than persistent truths.

  10. Blood Type Puzzle.

    Science.gov (United States)

    Kelly, Janet

    1997-01-01

    Presents a blood type puzzle that provides a visual, hands-on mechanism by which students can examine blood group reactions. Offers students an opportunity to construct their own knowledge about blood types. (JRH)

  11. Facts about Type 2

    Medline Plus

    Full Text Available ... Enroll in the Living WIth Type 2 Diabetes Program Gestational What is Gestational Diabetes? How to Treat ... Enroll in the Living WIth Type 2 Diabetes Program In It Together We Can Help Center for ...

  12. Preventing Type 2 Diabetes

    Science.gov (United States)

    ... Sexual, & Bladder Problems Clinical Trials Preventing Type 2 Diabetes Perhaps you have learned that you have a ... I lower my chances of developing type 2 diabetes? Research such as the Diabetes Prevention Program shows ...

  13. Facts about Type 2

    Medline Plus

    Full Text Available ... Infographics Living with Diabetes Home Recently Diagnosed Where Do I Begin With Type2? Living With Type 1 ... Diabetes at School Tour de Cure Women's Series Do-It-Yourself Fundraising Become a Volunteer American Diabetes ...

  14. Facts about Type 2

    Medline Plus

    Full Text Available ... Type 1 Diabetes Enroll in the Living WIth Type 2 Diabetes Program In It Together We Can Help Center for Information Legal Assistance Success Stories ... Tips for Caregivers ...

  15. Types of Stem Cells

    Science.gov (United States)

    ... Stem Cell Glossary Search Toggle Nav Types of Stem Cells Stem cells are the foundation from which all ... Learn About Stem Cells > Types of Stem Cells Stem cells Stem cells are the foundation for every organ ...

  16. Facts about Type 2

    Medline Plus

    Full Text Available ... and Type 2 Diabetes Know Your Rights Employment Discrimination Health Care Professionals Law Enforcement Driver's License For ... 1 Type 2 Gestational Myths Statistics Common Terms Genetics Living With Diabetes Recently Diagnosed Treatment & Care Complications ...

  17. Facts about Type 2

    Medline Plus

    Full Text Available ... Your Risk Alert Day Diabetes Basics Home Symptoms Diagnosis America's Diabetes Challenge Type 1 Type 2 Facts ... Online Community Site Menu Are You at Risk? Diagnosis Lower Your Risk Risk Test Alert Day Prediabetes ...

  18. Facts about Type 2

    Medline Plus

    Full Text Available ... Type 2 Diabetes Risk Test Lower Your Risk Healthy Eating Overweight Smoking High Blood Pressure Physical Activity High ... type 2 can control their blood glucose with healthy eating and being active. But, your doctor may need ...

  19. Different Types of Lupus

    Science.gov (United States)

    ... Twitter Facebook Pinterest Email Print Different types of lupus Lupus Foundation of America September 18, 2017 Resource ... lupus. Learn more about each type below. Systemic lupus erythematosus Systemic lupus is the most common form ...

  20. Facts about Type 2

    Medline Plus

    Full Text Available ... Type 1 Diabetes Get Started Safely Get And Stay Fit Types of Activity Weight Loss Assess Your Lifestyle Getting Started Food Choices In My Community Home Find Your Local Office Find your local diabetes ...

  1. Facts about Type 2

    Medline Plus

    Full Text Available ... En Español Type 1 Type 2 About Us Online Community Meal Planning Sign In Search: Search More ... Generation of Brilliant Researchers Diabetes Pro: Professional Resources Online We Support Your Doctor Clinical Practice Guidelines Patient ...

  2. Facts about Type 2

    Medline Plus

    Full Text Available ... People Working to Stop Diabetes Common Terms Diabetes Statistics Infographics Living with Diabetes Home Recently Diagnosed Where ... Basics Symptoms Type 1 Type 2 Gestational Myths Statistics Common Terms Genetics Living With Diabetes Recently Diagnosed ...

  3. Facts about Type 2

    Medline Plus

    Full Text Available ... Know Your Risk Diabetes Basics Symptoms Type 1 Type 2 Gestational Myths Statistics Common Terms Genetics Living With Diabetes Recently Diagnosed Treatment & Care Complications Health Insurance For ...

  4. Facts about Type 2

    Medline Plus

    Full Text Available ... 2 Type 2 diabetes is the most common form of diabetes. In type 2 diabetes, your body ... Sign Up Thank you for signing up ' + ' '); $('.survey-form').show(); }, success: function (data) { $('#survey-errors').remove(); $('.survey- ...

  5. Types of chemotherapy

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000910.htm Types of chemotherapy To use the sharing features on this page, ... cancer.org/treatment/treatments-and-side-effects/treatment-types/chemotherapy/how-chemotherapy-drugs-work.html . Updated February 15, ...

  6. Facts about Type 2

    Medline Plus

    Full Text Available ... Us in the Fight for a Cure Your tax-deductible gift today can fund critical diabetes research ... Care of Type 2 Diabetes This two-page introduction to type 2 diabetes is in PDF format ...

  7. Facts about Type 2

    Medline Plus

    Full Text Available ... About Type 2 Recently Diagnosed Treatment and Care Blood Glucose Control Complications Medication Doctors, Nurses & More Enroll in the Living With Type 2 Diabetes Program donate en -- A Future Without Diabetes - a- ...

  8. Facts about Type 2

    Medline Plus

    Full Text Available ... or insulin to help you meet your target blood glucose levels. Type 2 usually gets worse over time – even if ... About Type 2 Recently Diagnosed Treatment and Care Blood Glucose ... Living With Type 2 Diabetes Program donate en -- A Future Without ...

  9. Diabetes Type 2

    Science.gov (United States)

    Diabetes means your blood glucose, or blood sugar, levels are too high. With type 2 diabetes, the more common type, your body does not ... You have a higher risk of type 2 diabetes if you are older, have obesity, have a ...

  10. Facts about Type 2

    Medline Plus

    Full Text Available ... from Diabetes Forecast® magazine: lp-type-2, . In this section Diabetes Basics Type 2 Facts About Type ... ensureArray(data.submitSurveyResponse.errors); $.each(surveyErrors, function () { if (this.errorField) { $('input[name="' + this.errorField + '"]').closest('.form-group') . ...

  11. Diabetes, Type 1

    OpenAIRE

    Riazi, Afsane; Bradley, Clare

    2007-01-01

    This chapter provides an overview of the role of psychological stress in Type 1 diabetes. Studies relating to stress and Type 1 diabetes onset and control, as well as the evidence relating to stress management training in people with Type 1 diabetes are discussed.

  12. Osteogenesis imperfecta type V

    DEFF Research Database (Denmark)

    Rauch, Frank; Moffatt, Pierre; Cheung, Moira

    2013-01-01

    Osteogenesis imperfecta (OI) type V is an autosomal dominant bone fragility disorder that we had described a decade ago. Recent research has shown that OI type V is caused by a recurrent c.-14C>T mutation in IFITM5. In the present study, we assessed all patients diagnosed with OI type V at our...

  13. Facts about Type 2

    Medline Plus

    Full Text Available ... Home Prevention Diagnosing Diabetes and Learning About Prediabetes Type 2 Diabetes Risk Test Lower Your Risk Healthy Eating Overweight ... About Type 2 Enroll in the Living WIth Type 2 Diabetes Program Gestational What is Gestational Diabetes? How to ...

  14. Type Systems for Bigraphs

    DEFF Research Database (Denmark)

    Elsborg, Ebbe; Hildebrandt, Thomas; Sangiorgi, Davide

    of controls and a set of reaction rules, collectively a bigraphical reactive system (BRS). Possible advantages of developing bigraphical type systems include: a deeper understanding of a type system itself and its properties; transfer of the type systems to the concrete family of calculi that the BRS models...

  15. Facts about Type 2

    Medline Plus

    Full Text Available ... or insulin to help you meet your target blood glucose levels. Type 2 usually gets worse over time – even if ... About Type 2 Recently Diagnosed Treatment and Care Blood Glucose ... the Living With Type 2 Diabetes Program donate en -- A Future Without ...

  16. Tension Type Headache: Evaluation of Chronic Type

    Directory of Open Access Journals (Sweden)

    Ömer Karadaş

    2013-11-01

    Full Text Available Tension type headache(TTH which is a primary headache has episodic and chronic forms. Episodic TTH (ETTH can also be frequent-type and non-frequent-type. According to population-based studies, annual prevalence rates are 38.3% for ETTH and 2.2% for chronic TTH (CTTH. Patients can shift between the sub-groups of TTH. In particular, patients with ETTH are at risk of developing CTTH. Peripheral and central nociceptive mechanism are thought to be responsible in occurrence of TTH. Psychiatric disorders are frequently associated with TTH. Although basic and combined analgesics are used in acute treatment and antidepresants are used in prophylaxis, new treatment modalities are needed.

  17. Guarded Type Promotion

    DEFF Research Database (Denmark)

    Winther, Johnni

    2011-01-01

    conditional using the instanceof operator and thus the cast type is redundantly mentioned twice. We propose a new typing rule for Java called Guarded Type Promotion aimed at eliminating the need for the explicit casts when guarded. This new typing rule is backward compatible and has been fully implemented...... in a Java 6 compiler. Through our extensive testing of real-life code we show that guarded casts account for approximately one fourth of all casts and that Guarded Type Promotion can eliminate the need for 95 percent of these guarded casts....

  18. Improving Precision of Types

    DEFF Research Database (Denmark)

    Winther, Johnni

    Types in programming languages provide a powerful tool for the programmer to document the code so that a large aspect of the intent can not only be presented to fellow programmers but also be checked automatically by compilers. The precision with which types model the behavior of programs...... is crucial to the quality of these automated checks, and in this thesis we present three different improvements to the precision of types in three different aspects of the Java programming language. First we show how to extend the type system in Java with a new type which enables the detection of unintended...

  19. Type B Drum packages

    International Nuclear Information System (INIS)

    Edwards, W.S.

    1995-11-01

    The Type B Drum package is a container in which a single drum containing Type B quantities of radioactive material will be packaged for shipment. The Type B Drum containers are being developed to fill a void in the packaging and transportation capabilities of the US Department of Energy (DOE), as no double containment packaging for single drums of Type B radioactive material is currently available. Several multiple-drum containers and shielded casks presently exist. However, the size and weight of these containers present multiple operational challenges for single-drum shipments. The Type B Drum containers will offer one unshielded version and, if needed, two shielded versions, and will provide for the option of either single or double containment. The primary users of the Type B Drum container will be any organization with a need to ship single drums of Type B radioactive material. Those users include laboratories, waste retrieval facilities, emergency response teams, and small facilities

  20. TypeSan : Practical type confusion detection

    NARCIS (Netherlands)

    Haller, Istvan; Jeon, Yuseok; Peng, Hui; Payer, Mathias; Giuffrida, Cristiano; Bos, Herbert; Van Der Kouwe, Erik

    2016-01-01

    The low-level C++ programming language is ubiquitously used for its modularity and performance. Typecasting is a fundamental concept in C++ (and object-oriented programming in general) to convert a pointer from one object type into another. However, downcasting (converting a base class pointer to a

  1. Honesty by Typing

    OpenAIRE

    Bartoletti , Massimo; Scalas , Alceste; Tuosto , Emilio; Zunino , Roberto

    2013-01-01

    We propose a type system for a calculus of contracting processes. Processes can establish sessions by stipulating contracts, and then can interact either by keeping the promises made, or not. Type safety guarantees that a typeable process is honest - that is, it abides by the contracts it has stipulated in all possible contexts, even in presence of dishonest adversaries. Type inference is decidable, and it allows to safely approximate the honesty of processes using either synchronous or async...

  2. Mastering TypeScript

    CERN Document Server

    Rozentals, Nathan

    2015-01-01

    Whether you are a JavaScript developer aiming to learn TypeScript, or an experienced TypeScript developer wanting to take your skills to the next level, this book is for you. From basic to advanced language constructs, test-driven development, and object-oriented techniques, you will learn how to get the most out of the TypeScript language.

  3. Facts about Type 2

    Medline Plus

    Full Text Available ... Type 2 Diabetes Know Your Rights Employment Discrimination Health Care Professionals Law ... Your Plate Gluten Free Diets Meal Planning for Vegetarian Diets Cook with Heart- ...

  4. Diabetes mellitus type 1

    OpenAIRE

    Desta, Semere Tekeste

    2017-01-01

    Høgskulen på Vestlandet Avdeling for helsefag for sykepleiere Tittel: Diabetes type 1 Bakgrunn for val av tema: I 2000 var det ca. 130 000 personer i Norge med diabetes, av disse hadde ca. 20 000 diabetes type 1. I dag er det ca. 230 000 personer som har diabetes i Norge. Av disse ca. 28 000 type 1 diabetes. Tallet viser hvor alvorlig sykdommen er, fordi det har vært og fortsatt er, en økning av antall diabetikere i Norge. Type 1 diabetes kan komme i alle aldersgrupper, men vanligvis...

  5. TypeScript revealed

    CERN Document Server

    Maharry, Dan

    2013-01-01

    TypeScript Revealed is a quick 100-page guide to Anders Hejlsberg's new take on JavaScript. With this brief, fast-paced introduction to TypeScript, .NET, Web and Windows 8 application developers who are already familiar with JavaScript will easily get up to speed with TypeScript and decide whether or not to start incorporating it into their own development. TypeScript is 'JavaScript for Application-scale development'; a superset of JavaScript that brings to it an additional object-oriented-like syntax familiar to .NET programmers that compiles down into simple, clean JavaScript that any browse

  6. Type Ia Supernova Cosmology

    Science.gov (United States)

    Leibundgut, B.; Sullivan, M.

    2018-03-01

    The primary agent for Type Ia supernova cosmology is the uniformity of their appearance. We present the current status, achievements and uncertainties. The Hubble constant and the expansion history of the universe are key measurements provided by Type Ia supernovae. They were also instrumental in showing time dilation, which is a direct observational signature of expansion. Connections to explosion physics are made in the context of potential improvements of the quality of Type Ia supernovae as distance indicators. The coming years will see large efforts to use Type Ia supernovae to characterise dark energy.

  7. Facts about Type 2

    Medline Plus

    Full Text Available ... steps you take Help change the conversation about type 2 diabetes. Recipes and More: Diabetes Food Hub - ... }, success: function (data) { $('#survey-errors').remove(); $('. ...

  8. Facts about Type 2

    Medline Plus

    Full Text Available ... Plate Gluten Free Diets Meal Planning for Vegetarian Diets Cook with Heart-Healthy Foods Holiday ... Carbohydrates Types of Carbohydrates Carbohydrate Counting Make Your Carbs ...

  9. Facts about Type 2

    Medline Plus

    Full Text Available ... 2383) Give by Mail Close www.diabetes.org > Diabetes Basics > Type 2 Share: Print Page Text Size: A A A ... 2 diabetes is the most common form of diabetes. In type 2 diabetes, your body does not use insulin properly. ...

  10. Facts about Type 2

    Medline Plus

    Full Text Available ... to help you meet your target blood glucose levels. Type 2 usually gets worse over time – even if you don’t need medications at first, you may need to later on. Some groups have a higher risk for developing type 2 diabetes than ...

  11. Types of Anesthesia

    Science.gov (United States)

    ... Videos for Educators Search English Español Types of Anesthesia KidsHealth / For Teens / Types of Anesthesia What's in ... Get? Print en español Tipos de anestesia About Anesthesia Anesthesia is broken down into three main categories: ...

  12. Diabetes Type 1

    Science.gov (United States)

    Diabetes means your blood glucose, or blood sugar, levels are too high. With type 1 diabetes, your pancreas does not make insulin. Insulin is ... kidneys, nerves, and gums and teeth. Type 1 diabetes happens most often in children and young adults ...

  13. Type 1 Diabetes Facts

    Science.gov (United States)

    ... Affiliates JDRF Celebrity Ambassadors JDRF Logo Usage Contact Us Donate Events More Type 1 Diabetes Facts Type 1 diabetes (T1D) is an autoimmune ... about Insulin and T1D Learn More What Is Diabetes? Causes of T1D The Complexity of Diagnosing ... US CAREERS NEWSROOM FOR RESEARCHERS © JDRF 2018 • Privacy Policy • ...

  14. Facts about Type 2

    Medline Plus

    Full Text Available ... as well as the aged population. Patient Education Materials — Taking Care of Type 2 Diabetes This two-page introduction to type 2 diabetes is in PDF format so you can download it, print it, and hand it out to patients. You ...

  15. Facts about Type 2

    Medline Plus

    Full Text Available ... or insulin to help you meet your target blood glucose levels. Type 2 usually gets worse over time – even if you don’t need medications at first, you may need to later on. Some groups have a higher risk for developing type 2 ...

  16. Flash-Type Discrimination

    Science.gov (United States)

    Koshak, William J.

    2010-01-01

    This viewgraph presentation describes the significant progress made in the flash-type discrimination algorithm development. The contents include: 1) Highlights of Progress for GLM-R3 Flash-Type discrimination Algorithm Development; 2) Maximum Group Area (MGA) Data; 3) Retrieval Errors from Simulations; and 4) Preliminary Global-scale Retrieval.

  17. Tension type headache

    Directory of Open Access Journals (Sweden)

    Debashish Chowdhury

    2012-01-01

    Full Text Available Tension type headaches are common in clinical practice. Earlier known by various names, the diagnosis has had psychological connotations. Recent evidence has helped clarify the neurobiological basis and the disorder is increasingly considered more in the preview of neurologists. The classification, clinical features, differential diagnosis and treatment of tension type headache are discussed in this paper.

  18. Facts about Type 2

    Medline Plus

    Full Text Available ... org > Diabetes Basics > Type 2 Share: Print Page Text Size: A A A Listen En Español Facts ... Type 2 Education Series Hear audio clips and full recordings of past Q&A events at your ...

  19. Molecular Typing and Differentiation

    Science.gov (United States)

    In this chapter, general background and bench protocols are provided for a number of molecular typing techniques in common use today. Methods for the molecular typing and differentiation of microorganisms began to be widely adopted following the development of the polymerase chai...

  20. Beyond Type D personality

    DEFF Research Database (Denmark)

    Pelle, Aline J; Pedersen, Susanne S.; Szabó, Balázs M

    2009-01-01

    Type D personality has been associated with impaired health status in chronic heart failure (CHF), but other psychological factors may also be important.......Type D personality has been associated with impaired health status in chronic heart failure (CHF), but other psychological factors may also be important....

  1. Facts about Type 2

    Medline Plus

    Full Text Available ... a Member Donate Now! One Time Monthly In Memory In Honor Become a Member En Español Type 1 Type 2 About Us Online Community Meal Planning Sign In Search: Search More Sites Search ≡ Are You At Risk? Diabetes Basics Living with Diabetes Food & Fitness In My Community Advocacy Research & Practice Ways ...

  2. Facts about Type 2

    Medline Plus

    Full Text Available ... Honor Donation Donate by phone at 1-800-DIABETES (1-800-342-2383) Donate by mail Why Give? ... My Health Advisor Tools to Know Your Risk Diabetes Basics Symptoms Type 1 Type 2 Gestational Myths Statistics Common Terms Genetics ...

  3. Personality types of entrepreneurs.

    Science.gov (United States)

    Müller, Günter F; Gappisch, Cathrin

    2005-06-01

    85 German entrepreneurs were psychometrically assessed on 12 primary trait characteristics. The sample consisted of 49 men and 36 women whose mean age was 45.6 yr. (SD= 10.3). Occupational domains were production (40%) and services (60%). The mean duration of entrepreneurship within these domains was 13.1 yr. (SD=9.3). By factor analysis five personality types of entrepreneurs could be identified: Creative Acquisitor, Controlled Perseverator, Distant Achiever, Rational Manager, and Egocentric Agitator. These types correspond with types found in research by Miner and with the Myer-Briggs Indicator. In addition, correlations between general type potential and both job and life satisfaction of entrepreneurs were found. The results are discussed with regard to intercultural stability of personality types and implications for research and application.

  4. Types Of Christian Tourism

    Directory of Open Access Journals (Sweden)

    Cornelia Petroman

    2015-10-01

    Full Text Available Christian tourism is asub-type of tourism where pilgrims travel alone or in group as missionaries orpilgrims or to spend their free time to recollect; it attracts a large numberof travellers. Christian tourism can be practiced by religious young people,missionaries, participants to religious convents, amateurs of religiouscruises, religious camps, visitors of religious attractions, religiousadventurers. Christian tourism can be considered a sub-type of religioustourism because of the large number of people involved in this type of tourismworldwide. Christian tourism as a sub-category of religious tourism coversthree main sub-types: traditional pilgrimage practiced by most world religions,missionary travel to different areas in the world, and confessional voyage. Thestructure of hospitality industry is common to all types of tourism but, fortraditional pilgrimage, there must be special places for the pilgrims to sleep,eat and pray, because they belong, in most cases, to the medium-income touristcategory.

  5. Typed ψ-calculi

    DEFF Research Database (Denmark)

    Hüttel, Hans

    2011-01-01

    A large variety of process calculi extend the pi-calculus with more general notions of messages. Bengtson et al. have shown that many of these pi-like calculi can be expressed as so-called psi-calculi. In this paper, we describe a simple type system for psi-calculi. The type system satisfies a su...... for the distributed pi-calculus of Hennessy and Riely and finally show how existing type systems for secrecy and authenticity in the spi calculus can be represented and shown to be safe.......A large variety of process calculi extend the pi-calculus with more general notions of messages. Bengtson et al. have shown that many of these pi-like calculi can be expressed as so-called psi-calculi. In this paper, we describe a simple type system for psi-calculi. The type system satisfies...... a subject reduction property and a general notion of channel safety. A number of existing systems are shown to be instances of our system, and other, new type systems can also be obtained. We first present a new type system for the calculus of explicit fusions by Wischik and Gardner, then one...

  6. Diabetes mellitus type 1

    OpenAIRE

    Tøraasen, Lisa Vangen; Al-Sultan, Zainab

    2014-01-01

    Bacheloroppgave i sykepleie, 2014 Hvert år blir rundt 600 nordmenn diagnostisert med sykdommen diabetes type 1, og Norge er et av landene i verden med størst andel av barnediabetes. I dag er det 15 000- 20 000 personer i Norge som har diabetes type 1, og antall barn som får diabetes har fordoblet seg de siste 30 årene (Diabetesforbundet, 2014). Problemstillingen vår gikk ut på hvordan sykepleiere kan veilede og undervise ungdom med nyoppdaget diabetes type på sykehus. Ut i fra litteraturst...

  7. Diabetes mellitus type 1

    OpenAIRE

    Tøraasen, Lisa Vangen; Al-Sultan, Zainab

    2014-01-01

    Hvert år blir rundt 600 nordmenn diagnostisert med sykdommen diabetes type 1, og Norge er et av landene i verden med størst andel av barnediabetes. I dag er det 15 000- 20 000 personer i Norge som har diabetes type 1, og antall barn som får diabetes har fordoblet seg de siste 30 årene (Diabetesforbundet, 2014). Problemstillingen vår gikk ut på hvordan sykepleiere kan veilede og undervise ungdom med nyoppdaget diabetes type på sykehus. Ut i fra litteraturstudiet har vi arbeidet oss frem for å ...

  8. Action Type Deontic Logic

    DEFF Research Database (Denmark)

    Bentzen, Martin Mose

    2014-01-01

    A new deontic logic, Action Type Deontic Logic, is presented. To motivate this logic, a number of benchmark cases are shown, representing inferences a deontic logic should validate. Some of the benchmark cases are singled out for further comments and some formal approaches to deontic reasoning...... are evaluated with respect to the benchmark cases. After that follows an informal introduction to the ideas behind the formal semantics, focussing on the distinction between action types and action tokens. Then the syntax and semantics of Action Type Deontic Logic is presented and it is shown to meet...

  9. Type 2 diabetes models

    DEFF Research Database (Denmark)

    Gram, Dorte Xenia

    2012-01-01

    This chapter deals with type 2 diabetes in vivo models and techniques suitable for testing new anti-diabetic compounds. In particular, the testing of TRP antagonist for beneficial effects against type 2 diabetes is considered. There are many choices of both in vitro techniques and in vivo models......, impaired glucose tolerance, impaired insulin secretion, and insulin resistance in vivo and should, thus, be sufficient to demonstrate preclinical proof of concept of a TRP antagonist in type 2 diabetes in rodents. The experiments are suggestions and could be replaced or supplemented by others....

  10. Parametric compositional data types

    DEFF Research Database (Denmark)

    Bahr, Patrick; Hvitved, Tom

    2012-01-01

    In previous work we have illustrated the benefits that compositional data types (CDTs) offer for implementing languages and in general for dealing with abstract syntax trees (ASTs). Based on Swierstra's data types \\'a la carte, CDTs are implemented as a Haskell library that enables the definition...... of recursive data types and functions on them in a modular and extendable fashion. Although CDTs provide a powerful tool for analysing and manipulating ASTs, they lack a convenient representation of variable binders. In this paper we remedy this deficiency by combining the framework of CDTs with Chlipala...

  11. Type I supernova models

    International Nuclear Information System (INIS)

    Canal, Ramon; Labay, Javier; Isern, Jordi

    1987-01-01

    We briefly describe the characteristics of Type I supernova outbursts and we present the theoretical models so far advanced to explain them. We especially insist on models based on the thermonuclear explosion of a white dwarf in a close binary system, even regarding the recent division of Type I supernovae into the Ia and Ib subtypes. Together with models assuming explosive thermonuclear burning in a fluid interior, we consider in some detail those based on partially solid interiors. We finally discuss models that incorporate nonthermonuclear energy contributions, suggested in order to explain Type Ib outbursts. (Author)

  12. Tethering sockets and wrenches

    Science.gov (United States)

    Johnson, E. P.

    1990-01-01

    The tethering of sockets and wrenches was accomplished to improve the safety of working over motor segments. To accomplish the tethering of the sockets to the ratchets, a special design was implemented in which a groove was machined into each socket. Each socket was then fitted with a snap ring that can spin around the machined groove. The snap ring is tethered to the handle of the ratchet. All open end wrenches are also tethered to the ratchet or to the operator, depending upon the type. Tests were run to ensure that the modified tools meet torque requirements. The design was subsequently approved by Space Safety.

  13. Tethering sockets and wrenches

    Science.gov (United States)

    Johnson, E. P.

    1990-07-01

    The tethering of sockets and wrenches was accomplished to improve the safety of working over motor segments. To accomplish the tethering of the sockets to the ratchets, a special design was implemented in which a groove was machined into each socket. Each socket was then fitted with a snap ring that can spin around the machined groove. The snap ring is tethered to the handle of the ratchet. All open end wrenches are also tethered to the ratchet or to the operator, depending upon the type. Tests were run to ensure that the modified tools meet torque requirements. The design was subsequently approved by Space Safety.

  14. Facts about Type 2

    Medline Plus

    Full Text Available ... make enough insulin to keep your blood glucose levels normal. Type 2 is treated with lifestyle changes, ... starved for energy. Over time, high blood glucose levels may hurt your eyes, kidneys, nerves or heart. ...

  15. Facts about Type 2

    Medline Plus

    Full Text Available ... and Learning About Prediabetes Type 2 Diabetes Risk Test Lower Your Risk Healthy Eating Overweight Smoking High Blood Pressure Physical Activity High Blood Glucose My Health Advisor Tools ...

  16. Making Type Inference Practical

    DEFF Research Database (Denmark)

    Schwartzbach, Michael Ignatieff; Oxhøj, Nicholas; Palsberg, Jens

    1992-01-01

    We present the implementation of a type inference algorithm for untyped object-oriented programs with inheritance, assignments, and late binding. The algorithm significantly improves our previous one, presented at OOPSLA'91, since it can handle collection classes, such as List, in a useful way. Abo......, the complexity has been dramatically improved, from exponential time to low polynomial time. The implementation uses the techniques of incremental graph construction and constraint template instantiation to avoid representing intermediate results, doing superfluous work, and recomputing type information....... Experiments indicate that the implementation type checks as much as 100 lines pr. second. This results in a mature product, on which a number of tools can be based, for example a safety tool, an image compression tool, a code optimization tool, and an annotation tool. This may make type inference for object...

  17. Facts about Type 2

    Medline Plus

    Full Text Available ... to Give Close Are You at Risk? Home Prevention Diagnosing Diabetes and Learning About Prediabetes Type 2 ... Disease (Nephropathy) Gastroparesis Mental Health Step On Up Treatment & Care Blood Glucose Testing Medication Doctors, Nurses & More ...

  18. Facts about Type 2

    Medline Plus

    Full Text Available ... Right away, your cells may be starved for energy. Over time, high blood glucose levels may hurt ... lwt2d-en.html Have Type 2 Diabetes? Our free program will help you live well. More from ...

  19. Facts about Type 2

    Medline Plus

    Full Text Available ... Risk Test Lower Your Risk Healthy Eating Overweight Smoking High Blood Pressure Physical Activity High Blood Glucose ... Index Low-Calorie Sweeteners Sugar and Desserts Fitness Exercise & Type 1 Diabetes Get Started Safely Get And ...

  20. Facts about Type 2

    Medline Plus

    Full Text Available ... for Association Events Messaging Tools Recruiting Advocates Local Market Planning Training Webinars News & Events Advocacy News Call ... medications or insulin to help you meet your target blood glucose levels. Type 2 usually gets worse ...

  1. Treating Type 2 Diabetes

    Science.gov (United States)

    ... health care team is there for you. Your child's diabetes management plan should be easy to understand, detailed, ... Can Diabetes Be Prevented? Monitoring Blood Sugar Your Child's Diabetes Health Care Team Medicines for Diabetes Type 2 ...

  2. Facts about Type 2

    Medline Plus

    Full Text Available ... Future Without Diabetes - a-future-without-diabetes-2.html A Future Without Diabetes Donate towards research today ... Donate Today We Can Help - we-can-help.html Chat Online Chat Closed engagement en -- Have Type ...

  3. Facts about Type 2

    Medline Plus

    Full Text Available ... Diabetes Risk Test Lower Your Risk Healthy Eating Overweight Smoking High Blood Pressure Physical Activity High Blood ... For Parents & Kids Safe at School Everyday Life Children and Type 2 Diabetes Know Your Rights Employment ...

  4. Facts about Type 2

    Medline Plus

    Full Text Available ... is Gestational Diabetes? How to Treat Gestational Diabetes Genetics of Diabetes Diabetes Myths A Day in the ... 1 Type 2 Gestational Myths Statistics Common Terms Genetics Living With Diabetes Recently Diagnosed Treatment & Care Complications ...

  5. Types of Pesticide Ingredients

    Science.gov (United States)

    Pesticide active ingredients are described by the types of pests they control or how they work. For example, algicides kill algae, biopesticides are derived from natural materials, and insecticides kill insects.

  6. Facts about Type 2

    Medline Plus

    Full Text Available ... breast cancer and AIDS combined. Your gift today will help us get closer to curing diabetes and ... html Have Type 2 Diabetes? Our free program will help you live well. More from diabetes.org ...

  7. Facts about Type 2

    Medline Plus

    Full Text Available ... Practice Ways to Give Close Are You at Risk? Home Prevention Diagnosing Diabetes and Learning About Prediabetes Type 2 Diabetes Risk Test Lower Your Risk Healthy Eating Overweight Smoking ...

  8. Facts about Type 2

    Medline Plus

    Full Text Available ... You at Risk? Home Prevention Diagnosing Diabetes and Learning About Prediabetes Type 2 Diabetes Risk Test Lower ... Find Your Local Office Find your local diabetes education program Calendar of Events Wellness Lives Here Awareness ...

  9. Facts about Type 2

    Medline Plus

    Full Text Available ... Meals Diabetes Meal Plans Create Your Plate Gluten Free Diets Meal Planning for Vegetarian Diets Cook with ... lwt2d-en.html Have Type 2 Diabetes? Our free program will help you live well. More from ...

  10. Teaching Typing by Transcription.

    Science.gov (United States)

    Janson, Eleanor L.

    1978-01-01

    In addition to discussing the program for teaching typewriting to blind students using the auditory mode, the article presents a sample lesson in print, along with typing rates achieved by earlier classes. (DLS)

  11. Facts about Type 2

    Medline Plus

    Full Text Available ... and Learning About Prediabetes Type 2 Diabetes Risk Test Lower Your Risk Healthy Eating Overweight Smoking High ... excused. 86 million Americans have prediabetes. Take the test. Know where you stand. More from diabetes.org ...

  12. Facts about Type 2

    Medline Plus

    Full Text Available ... Complications DKA (Ketoacidosis) & Ketones Kidney Disease (Nephropathy) Gastroparesis Mental Health Step On Up Treatment & Care Blood Glucose ... or heart. Some people with type 2 can control their blood glucose with healthy eating and being ...

  13. Facts about Type 2

    Medline Plus

    Full Text Available ... Diabetes Research & Practice Home We Are Research Leaders World's Largest Diabetes Meeting Recent Advances Type 1 Research ... 342-2383) Copyright 1995-2018. American Diabetes Association. All rights reserved. Use of this website constitutes acceptance ...

  14. Facts about Type 2

    Medline Plus

    Full Text Available ... Future Without Diabetes - a-future-without-diabetes-2.html A Future Without Diabetes Make your donation today ... Donate Today We Can Help - we-can-help.html Chat Online Chat Closed engagement en -- Have Type ...

  15. Facts about Type 2

    Medline Plus

    Full Text Available ... Life Children and Type 2 Diabetes Know Your Rights Employment Discrimination Health Care Professionals Law Enforcement Driver's ... going into cells, it can cause two problems: Right away, your cells may be starved for energy. ...

  16. Facts about Type 2

    Medline Plus

    Full Text Available ... Test Lower Your Risk Healthy Eating Overweight Smoking High Blood Pressure Physical Activity High Blood Glucose My Health Advisor Tools To Know Your Risk Alert Day Diabetes Basics Home Symptoms Diagnosis America's Diabetes Challenge Type ...

  17. Facts about Type 2

    Medline Plus

    Full Text Available ... Know Your Rights Employment Discrimination Health Care Professionals Law Enforcement Driver's License For Lawyers Food & Fitness Home ... make enough insulin to keep your blood glucose levels normal. Type 2 is treated with lifestyle changes, ...

  18. Facts about Type 2

    Medline Plus

    Full Text Available ... Medicare Medicaid & CHIP For Parents & Kids Safe at School Everyday Life Children and Type 2 Diabetes Know Your Rights Employment Discrimination Health Care Professionals Law Enforcement Driver's License For Lawyers ...

  19. Facts about Type 2

    Medline Plus

    Full Text Available ... A Day in the Life of Diabetes Famous People Working to Stop Diabetes Common Terms Diabetes Statistics ... hurt your eyes, kidneys, nerves or heart. Some people with type 2 can control their blood glucose ...

  20. Facts about Type 2

    Medline Plus

    Full Text Available ... You at Risk? Home Prevention Diagnosing Diabetes and Learning About Prediabetes Type 2 Diabetes Risk Test Lower ... EXPO Volunteer Opportunities Sponsorship and Exhibit Opportunities Camp Learning at Camp Find a Camp Fundraising Events Step ...

  1. Tissue types (image)

    Science.gov (United States)

    ... are 4 basic types of tissue: connective tissue, epithelial tissue, muscle tissue, and nervous tissue. Connective tissue supports ... binds them together (bone, blood, and lymph tissues). Epithelial tissue provides a covering (skin, the linings of the ...

  2. Types of Crude Oil

    Science.gov (United States)

    The petroleum industry often classifies these types by geographical source, but the classification scheme here is more useful in a spill cleanup scenario. It indicates general toxicity, physical state, and changes caused by time and weathering.

  3. Facts about Type 2

    Medline Plus

    Full Text Available ... the Living WIth Type 2 Diabetes Program In It Together We Can Help Center for Information Legal ... at School Tour de Cure Women's Series Do-It-Yourself Fundraising Become a Volunteer American Diabetes Month® ...

  4. Facts about Type 2

    Medline Plus

    Full Text Available ... Medicare Medicaid & CHIP For Parents & Kids Safe at School Everyday Life Children and Type 2 Diabetes Know ... Cure Father of the Year Stop Diabetes at School Tour de Cure Women's Series Do-It-Yourself ...

  5. Facts about Type 2

    Medline Plus

    Full Text Available ... for Association Events Messaging Tools Recruiting Advocates Local Market Planning Training Webinars News & Events Advocacy News Call ... Diabetes Basics > Type 2 Share: Print Page Text Size: A A A Listen En Español Facts About ...

  6. Facts about Type 2

    Medline Plus

    Full Text Available ... Risk? Home Prevention Diagnosing Diabetes and Learning About Prediabetes Type 2 Diabetes Risk Test Lower Your Risk ... Diagnosis Lower Your Risk Risk Test Alert Day Prediabetes My Health Advisor Tools to Know Your Risk ...

  7. Facts about Type 2

    Medline Plus

    Full Text Available ... hotelscom.html Ways to Give Vacation for Donations Travel bookings completed through Hotels.com give 5% back ... about type 2 diabetes. Recipes and More: Diabetes Food Hub - recipes-and-more-1.html Recipes and ...

  8. Facts about Type 2

    Medline Plus

    Full Text Available ... Type 2 Diabetes Program In It Together We Can Help Center for Information Legal Assistance Success Stories ... with Heart-Healthy Foods Holiday Meal Planning What Can I Eat? Making Healthy Food Choices Diabetes Superfoods ...

  9. Facts about Type 2

    Medline Plus

    Full Text Available ... and Learning About Prediabetes Type 2 Diabetes Risk Test Lower Your Risk Healthy Eating Overweight Smoking High Blood Pressure Physical Activity High Blood Glucose My Health ...

  10. Facts about Type 2

    Medline Plus

    Full Text Available ... Fruit Dairy Food Tips Eating Out Quick Meal Ideas Snacks Nutrient Content Claims Understanding Carbohydrates Types of ... our 2018 Tour de Cure events. Start your team today! More from diabetes.org Healthy Recipes: Delicious ...

  11. Facts about Type 2

    Medline Plus

    Full Text Available ... Us in the Fight for a Cure Your tax-deductible gift today can fund critical diabetes research ... Type 2 Diabetes Program Food & Fitness Food Recipes Planning Meals What Can I Eat Weight Loss Fitness ...

  12. Facts about Type 2

    Medline Plus

    Full Text Available ... and Learning About Prediabetes Type 2 Diabetes Risk Test Lower Your Risk Healthy Eating Overweight Smoking High ... You at Risk? Diagnosis Lower Your Risk Risk Test Alert Day Prediabetes My Health Advisor Tools to ...

  13. Facts about Type 2

    Medline Plus

    Full Text Available ... of Diabetes Diabetes Myths A Day in the Life of Diabetes Famous People Working to Stop Diabetes ... CHIP For Parents & Kids Safe at School Everyday Life Children and Type 2 Diabetes Know Your Rights ...

  14. Facts about Type 2

    Medline Plus

    Full Text Available ... for Association Events Messaging Tools Recruiting Advocates Local Market Planning Training Webinars News & Events Advocacy News Call ... Asian Americans/Pacific Islanders, as well as the aged population. Patient Education Materials — Taking Care of Type ...

  15. Facts about Type 2

    Medline Plus

    Full Text Available ... and Pacific Islanders American Indian/Alaska Native Programs Older ... may hurt your eyes, kidneys, nerves or heart. Some people with type 2 can control their blood glucose ...

  16. Facts about Type 2

    Medline Plus

    Full Text Available ... Diets Meal Planning for Vegetarian Diets Cook with Heart-Healthy Foods Holiday Meal Planning What Can I ... levels may hurt your eyes, kidneys, nerves or heart. Some people with type 2 can control their ...

  17. Facts about Type 2

    Medline Plus

    Full Text Available ... 2 Enroll in the Living WIth Type 2 Diabetes Program Gestational What is Gestational Diabetes? How to Treat Gestational Diabetes Genetics of Diabetes Diabetes Myths A Day in ...

  18. Facts about Type 2

    Science.gov (United States)

    ... Rights Employment Discrimination Health Care Professionals Law Enforcement Driver's License For Lawyers Food & Fitness Home Food MyFoodAdvisor ... Fit Types of Activity Weight Loss Assess Your Lifestyle Getting Started Food Choices In My Community Home ...

  19. Facts about Type 2

    Medline Plus

    Full Text Available ... Rights Employment Discrimination Health Care Professionals Law Enforcement Driver's License For Lawyers Food & Fitness Home Food MyFoodAdvisor ... Fit Types of Activity Weight Loss Assess Your Lifestyle Getting Started Food Choices In My Community Home ...

  20. Facts about Type 2

    Medline Plus

    Full Text Available ... Day in the Life of Diabetes Famous People Working to Stop Diabetes Common Terms Diabetes Statistics Infographics Living with Diabetes Home Recently Diagnosed Where Do I Begin With Type2? ...

  1. Facts about Type 2

    Medline Plus

    Full Text Available ... Up Treatment & Care Blood Glucose Testing Medication Doctors, Nurses & More Oral Health & Hygiene Women A1C Insulin Pregnancy ... and Care Blood Glucose Control Complications Medication Doctors, Nurses & More Enroll in the Living With Type 2 ...

  2. Facts about Type 2

    Medline Plus

    Full Text Available ... My Community Advocacy Research & Practice Ways to Give Close Are You at Risk? Home Prevention Diagnosing Diabetes ... 800-DIABETES (800-342-2383) Give by Mail Close www.diabetes.org > Diabetes Basics > Type 2 Share: ...

  3. Type 1 diabetes

    DEFF Research Database (Denmark)

    Green, Anders; Kyvik, Kirsten Ohm

    2001-01-01

    Prediction of Type 1 diabetes at individual level is relevant for any possible intervention before clinical disease develops. Currently available markers of Type 1 diabetes include genetic specificities and immune markers, in addition to a positive family history. This chapter reviews the measures...... and methods of importance in predicting Type 1 diabetes. Based on numerical examples it is demonstrated that available markers have a low level of performance, even when combined. Even so, combined marker information may allow for the identification of the large majority of the general population who...... is at very low disease risk. The impact at population level of predicting Type 1 diabetes varies between societies because the performance of markers depends on levels of disease risk and distribution of markers within a population. The incorporation of the influence of non-genetic etiological factors may...

  4. Facts about Type 2

    Medline Plus

    Full Text Available ... Are Research Leaders World's Largest Diabetes Meeting Recent Advances Type 1 Research Highlights Research Excellence Honorees How ... Diabetes causes more deaths a year than breast cancer and AIDS combined. Your gift today will help ...

  5. Facts about Type 2

    Medline Plus

    Full Text Available ... or heart. Some people with type 2 can control their blood glucose with healthy eating and being ... 2 Recently Diagnosed Treatment and Care Blood Glucose Control Complications Medication Doctors, Nurses & More Enroll in the ...

  6. Facts about Type 2

    Medline Plus

    Full Text Available ... Diagnosing Diabetes and Learning About Prediabetes Type 2 Diabetes Risk Test Lower Your Risk Healthy Eating Overweight Smoking High Blood Pressure Physical Activity High Blood Glucose My Health Advisor ...

  7. Facts about Type 2

    Medline Plus

    Full Text Available ... a Member Donate Now! One Time Monthly In Memory In Honor Become a Member En Español Type ... time Give monthly Give in honor Give in memory Donate Now Why Give? Nearly 30 million battle ...

  8. Facts about Type 2

    Medline Plus

    Full Text Available ... Eye Complications Neuropathy Foot Complications DKA (Ketoacidosis) & Ketones Kidney Disease (Nephropathy) Gastroparesis Mental Health Step On Up ... high blood glucose levels may hurt your eyes, kidneys, nerves or heart. Some people with type 2 ...

  9. Types of Heart Failure

    Science.gov (United States)

    ... Introduction Types of Heart Failure Classes of Heart Failure Heart Failure in Children Advanced Heart Failure • Causes and ... and procedures related to heart disease and stroke. Heart Failure Questions to Ask Your Doctor Use these questions ...

  10. Facts about Type 2

    Medline Plus

    Full Text Available ... Are Research Leaders World's Largest Diabetes Meeting Recent Advances Type 1 Research Highlights Research Excellence Honorees How ... breast cancer and AIDS combined. Your gift today will help us get closer to curing diabetes and ...

  11. Facts about Type 2

    Medline Plus

    Full Text Available ... for the Uninsured Medicare Medicaid & CHIP For Parents & Kids Safe at School Everyday Life Children and Type ... Diagnosed Treatment & Care Complications Health Insurance For Parents & Kids Know Your Rights We Can Help Enroll in ...

  12. Facts about Type 2

    Medline Plus

    Full Text Available ... Fit Types of Activity Weight Loss Assess Your Lifestyle Getting Started Food Choices In My Community Home Find Your Local Office Find your local diabetes education program Calendar of Events Wellness Lives Here ...

  13. Facts about Type 2

    Medline Plus

    Full Text Available ... a Member Donate Now! One Time Monthly In Memory In Honor Become a Member En Español Type ... 250 $500 Other Other Ways to Donate: In Memory Donation In Honor Donation Donate by phone at ...

  14. Facts about Type 2

    Medline Plus

    Full Text Available ... it can cause two problems: Right away, your cells may be starved for energy. Over time, high blood glucose levels may hurt your eyes, kidneys, nerves or heart. Some people with type ...

  15. Facts about Type 2

    Medline Plus

    Full Text Available ... of Events Wellness Lives Here Awareness Programs Hispanic Heritage Month African American Programs Latino Programs Asian Americans, ... 1 Type 2 Gestational Myths Statistics Common Terms Genetics Living With Diabetes Recently Diagnosed Treatment & Care Complications ...

  16. Multilocus Sequence Typing

    OpenAIRE

    Belén, Ana; Pavón, Ibarz; Maiden, Martin C.J.

    2009-01-01

    Multilocus sequence typing (MLST) was first proposed in 1998 as a typing approach that enables the unambiguous characterization of bacterial isolates in a standardized, reproducible, and portable manner using the human pathogen Neisseria meningitidis as the exemplar organism. Since then, the approach has been applied to a large and growing number of organisms by public health laboratories and research institutions. MLST data, shared by investigators over the world via the Internet, have been ...

  17. Type 1 diabetes

    OpenAIRE

    Atkinson, Mark A; Eisenbarth, George S; Michels, Aaron W

    2013-01-01

    Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes has grown substantially, particularly with regard to disease prediction and heterogeneity, pancreatic pathology, and epidemiology. Technological improvements in insulin pumps and continuous glucose monitors help patients with type 1 diabetes manage the challenge of lifelong insulin administration. Agents that show promise for averting debilitating disease-associated complications have also been identifi...

  18. Type extension trees

    DEFF Research Database (Denmark)

    Jaeger, Manfred

    2006-01-01

    We introduce type extension trees as a formal representation language for complex combinatorial features of relational data. Based on a very simple syntax this language provides a unified framework for expressing features as diverse as embedded subgraphs on the one hand, and marginal counts...... of attribute values on the other. We show by various examples how many existing relational data mining techniques can be expressed as the problem of constructing a type extension tree and a discriminant function....

  19. Effect of dielectrophoretic structuring on piezoelectric and pyroelectric properties of lead titanate-epoxy composites

    NARCIS (Netherlands)

    Khanbareh, H.; Zwaag, S. van der; Groen, W.A.

    2014-01-01

    Functional granular composites of lead titanate particles in an epoxy matrix prepared by dielectrophoresis show enhanced dielectric, piezoelectric and pyroelectric properties compared to 0-3 composites for different ceramic volume content from 10% to 50%. Two structuring parameters, the

  20. Dual-cycle dielectrophoretic collection rates for probing the dielectric properties of nanoparticles.

    Science.gov (United States)

    Bakewell, David J; Holmes, David

    2013-04-01

    A new DEP spectroscopy method and supporting theoretical model is developed to systematically quantify the dielectric properties of nanoparticles using continuously pulsed DEP collection rates. Initial DEP collection rates, that are dependent on the nanoparticle dielectric properties, are an attractive alternative to the crossover frequency method for determining dielectric properties. The new method introduces dual-cycle amplitude modulated and frequency-switched DEP (dual-cycle DEP) where the first collection rate with a fixed frequency acts as a control, and the second collection rate frequency is switched to a chosen value, such that, it can effectively probe the dielectric properties of the nanoparticles. The application of the control means that measurement variation between DEP collection experiments is reduced so that the frequency-switched probe collection is more effective. A mathematical model of the dual-cycle method is developed that simulates the temporal dynamics of the dual-cycle DEP nanoparticle collection system. A new statistical method is also developed that enables systematic bivariate fitting of the multifrequency DEP collection rates to the Clausius-Mossotti function, and is instrumental for determining dielectric properties. A Monte-Carlo simulation validates that collection rates improve estimation of the dielectric properties, compared with the crossover method, by exploiting a larger number of independent samples. Experiments using 200 nm diameter latex nanospheres suspended in 0.2 mS/m KCl buffer yield a nanoparticle conductivity of 26 mS/m that lies within 8% of the expected value. The results show that the dual-frequency method has considerable promise particularly for automated DEP investigations and associated technologies. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Preventing droplet deformation during dielectrophoretic centering of a compound emulsion droplet

    Science.gov (United States)

    Randall, Greg; Blue, Brent

    2012-11-01

    Compound droplets, or droplets-within-droplets, are traditionally key components in applications ranging from drug delivery to the food industry. Presently, millimeter-sized compound droplets are precursors for shell targets in inertial fusion energy work. However, a key constraint in target fabrication is a uniform shell wall thickness, which in turn requires a centered core droplet in the compound droplet precursor. Previously, Bei et al. (2009, 2010) have shown that compound droplets could be centered in a static fluid using an electric field of 0.7 kV/cm at 20 MHz. Randall et al. (2012) developed a process to center the core of a moving compound droplet, though the ~kV/cm field induced small (fluid mechanics and interfacial rheology perspective and we discuss the effective interfacial charge from an emulsifier and its impact on centering. Work funded by General Atomics Internal R&D.

  2. Simulation of dielectrophoretic assembly of carbon nanotubes using 3D finite element analysis

    International Nuclear Information System (INIS)

    Berger, S D; McGruer, N E; Adams, G G

    2015-01-01

    One of the most important methods for selective and repeatable assembly of carbon nanotubes (CNTs) is alternating current dielectrophoresis (DEP). This method has been demonstrated experimentally as a viable technique for nano-scale manufacturing of novel CNT based devices. Previous numerical analyses have studied the motion of nanotubes, the volume from which they are assembled, and the rate of assembly, but have been restricted by various simplifying assumptions. In this paper we present a method for simulating the motion and behavior of CNTs subjected to dielectrophoresis using a three-dimensional electrostatic finite element analysis. By including the CNT in the finite element model, we can accurately predict the effect of the CNT on the electric field and the resulting force distribution across the CNT can be determined. We have used this information to calculate the motion of CNTs assembling onto the electrodes, and show how they tend to move towards the center of an electrode and come into contact at highly skewed angles. Our analysis suggests that the CNTs move to the electrode gap only after initially contacting the electrodes. We have also developed a model of the elastic deformation of CNTs as they approach the electrodes demonstrating how the induced forces can significantly alter the CNT shape during assembly. These results show that the CNT does not behave as a rigid body when in close proximity to the electrodes. In the future this method can be applied to a variety of real electrode geometries on a case-by-case basis and will provide more detailed insight into the specific motion and assembly parameters necessary for effective DEP assembly. (paper)

  3. Dimensional analysis and prediction of dielectrophoretic crossover frequency of spherical particles

    Directory of Open Access Journals (Sweden)

    Che-Kai Yeh

    2017-06-01

    Full Text Available The manipulation of biological cells and micrometer-scale particles using dielectrophoresis (DEP is an indispensable technique for lab-on-a-chip systems for many biological and colloidal science applications. However, existing models, including the dipole model and numerical simulations based on Maxwell stress tensor (MST, cannot achieve high accuracy and high computation efficiency at the same time. The dipole model is widely used and provides adequate predictions on the crossover frequency of submicron particles, but cannot predict the crossover frequency for larger particles accurately; on the other hand, the MST method offers high accuracy for a wide variety of particle sizes and shapes, but is time-consuming and may lack predictive understanding of the interplay between key parameters. Here we present a mathematical model, using dimensional analysis and the Buckingham pi theorem, that permits high accuracy and efficiency in predicting the crossover frequency of spherical particles. The curve fitting and calculation are performed using commercial packages OriginLab and MATLAB, respectively. In addition, through this model we also can predict the conditions in which no crossover frequency exists. Also, we propose a pair of dimensionless parameters, forming a functional relation, that provide physical insights into the dependency of the crossover frequency on five key parameters. The model is verified under several scenarios using comprehensive MST simulations by COMSOL Multiphysics software (COMSOL, Inc. and some published experimental data.

  4. Dielectrophoretic deformation of thin liquid films induced by surface charge patterns on dielectric substrates

    NARCIS (Netherlands)

    Berendsen, C.W.J.; Kuijpers, C.J.; Zeegers, J.C.H.; Darhuber, A.A.

    2013-01-01

    We studied the deformation of thin liquid films induced by surface charge patterns at the solid–liquid interface quantitatively by experiments and numerical simulations. We deposited a surface charge distribution on dielectric substrates by applying potential differences between a conductive liquid

  5. Hybrid cell adhesive material for instant dielectrophoretic cell trapping and long-term cell function assessment.

    Science.gov (United States)

    Reyes, Darwin R; Hong, Jennifer S; Elliott, John T; Gaitan, Michael

    2011-08-16

    Dielectrophoresis (DEP) for cell manipulation has focused, for the most part, on approaches for separation/enrichment of cells of interest. Advancements in cell positioning and immobilization onto substrates for cell culture, either as single cells or as cell aggregates, has benefited from the intensified research efforts in DEP (electrokinetic) manipulation. However, there has yet to be a DEP approach that provides the conditions for cell manipulation while promoting cell function processes such as cell differentiation. Here we present the first demonstration of a system that combines DEP with a hybrid cell adhesive material (hCAM) to allow for cell entrapment and cell function, as demonstrated by cell differentiation into neuronlike cells (NLCs). The hCAM, comprised of polyelectrolytes and fibronectin, was engineered to function as an instantaneous cell adhesive surface after DEP manipulation and to support long-term cell function (cell proliferation, induction, and differentiation). Pluripotent P19 mouse embryonal carcinoma cells flowing within a microchannel were attracted to the DEP electrode surface and remained adhered onto the hCAM coating under a fluid flow field after the DEP forces were removed. Cells remained viable after DEP manipulation for up to 8 d, during which time the P19 cells were induced to differentiate into NLCs. This approach could have further applications in areas such as cell-cell communication, three-dimensional cell aggregates to create cell microenvironments, and cell cocultures.

  6. Investigation of parameters controlling the dielectrophoretic assembly of carbon nanotubes on microelectrodes

    DEFF Research Database (Denmark)

    Dimaki, Maria; Bøggild, Peter

    2008-01-01

    Networks of single-walled carbon nanotubes were assembled onto microelectrodes by dielectrophoresis. The dependence of the obtained networks on several assembly parameters such as bias voltage, field application time, frequency, electrode geometry and the nanotube solvent were investigated both s...

  7. Rapid fabrication of three-dimensional structures for dielectrophoretic sorting of lipid-containing organisms

    International Nuclear Information System (INIS)

    Schor, Alisha R; Buie, Cullen R

    2016-01-01

    In this work, we demonstrate a microfluidic particle sorter consisting of three-dimensional, conducting microposts. Our sorter uses dielectrophoresis (DEP) to sort high- and low-lipid phenotypes of the yeast Yarrowia lipolytica . Y. lipolytica is one of the many microorganisms being explored as a hydrocarbon source for biodiesel, Omega-3 additives, and other products derived from fatty acids. A rapid, non-destructive, lipid-based sorting tool would accelerate the commercialization of these products. Our device consists of an array of 105, 25 μ m wide gold microposts that span the height of a 15 μ m channel. This array generates an electric field in a microfluidic device that is uniform through the channel height, but has a custom-shaped non-uniformity in the horizontal directions. This is crucial in order to achieve continuous sorting using DEP, as it ensures all cells are exposed to the same conditions throughout the channel height. By using very low currents (100 μ A), we are able to electroplate these post arrays in fewer than 15 min. This is an order of magnitude improvement over previous reports of electroplated microstructures. With an applied signal of 250 MHz, 2.6 V pp in our device, we separate a heterogeneous population with a purity of 97.8% in the low-lipid stream and 71.4% in the high-lipid stream. The high-lipid stream purity can be improved by adjusting the spacing of the array. This unique protocol for the rapid fabrication of 3D microstructures has enabled the creation of a non-invasive sorting tool for genetically engineered, lipid-producing organisms. The ability to screen organisms based on lipid content will alleviate one of the major bottlenecks in commercialization of microbial biofuels. (paper)

  8. Dielectrophoretic positioning of single nanoparticles on atomic force microscope tips for tip-enhanced Raman spectroscopy.

    Science.gov (United States)

    Leiterer, Christian; Deckert-Gaudig, Tanja; Singh, Prabha; Wirth, Janina; Deckert, Volker; Fritzsche, Wolfgang

    2015-05-01

    Tip-enhanced Raman spectroscopy, a combination of Raman spectroscopy and scanning probe microscopy, is a powerful technique to detect the vibrational fingerprint of molecules at the nanometer scale. A metal nanoparticle at the apex of an atomic force microscope tip leads to a large enhancement of the electromagnetic field when illuminated with an appropriate wavelength, resulting in an increased Raman signal. A controlled positioning of individual nanoparticles at the tip would improve the reproducibility of the probes and is quite demanding due to usually serial and labor-intensive approaches. In contrast to commonly used submicron manipulation techniques, dielectrophoresis allows a parallel and scalable production, and provides a novel approach toward reproducible and at the same time affordable tip-enhanced Raman spectroscopy tips. We demonstrate the successful positioning of an individual plasmonic nanoparticle on a commercial atomic force microscope tip by dielectrophoresis followed by experimental proof of the Raman signal enhancing capabilities of such tips. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Focused ion beam patterning to dielectrophoretically assemble single nanowire based devices

    International Nuclear Information System (INIS)

    La Ferrara, V; Massera, E; Francia, G Di; Alfano, B

    2010-01-01

    Direct-write processing is increasingly taking place in nanodevice fabrication. In this work, Focused Ion Beam (FIB), a powerful tool in maskless micromachining, is used for electrode patterning onto a silicon/silicon nitride substrate. Then a single palladium nanowire is assembled between electrodes by means of dielectrophoresis (DEP). The nanowire morphology depends on the electrode pattern when DEP conditions are fixed. FIB/DEP combination overcomes the problem of nanowire electrical contamination due to gallium ion bombardment and the as-grown nanowire retains its basic electrical properties. Single nanowire based devices have been fabricated with this novel approach and have been tested as hydrogen sensors, confirming the reliability of this technology.

  10. Helical type vacuum container

    International Nuclear Information System (INIS)

    Owada, Kimio.

    1989-01-01

    Helical type vacuum containers in the prior art lack in considerations for thermal expansion stresses to helical coils, and there is a possibility of coil ruptures. The object of the present invention is to avoid the rupture of helical coils wound around the outer surface of a vacuum container against heat expansion if any. That is, bellows or heat expansion absorbing means are disposed to a cross section of a helical type vacuum container. With such a constitution, thermal expansion of helical coils per se due to temperature elevation of the coils during electric supply can be absorbed by expansion of the bellows or absorption of the heat expansion absorbing means. Further, this can be attained by arranging shear pins in the direction perpendicular to the bellows axis so that the bellows are not distorted when the helical coils are wound around the helical type vacuum container. (I.S.)

  11. Brauer type embedding problems

    CERN Document Server

    Ledet, Arne

    2005-01-01

    This monograph is concerned with Galois theoretical embedding problems of so-called Brauer type with a focus on 2-groups and on finding explicit criteria for solvability and explicit constructions of the solutions. The advantage of considering Brauer type embedding problems is their comparatively simple condition for solvability in the form of an obstruction in the Brauer group of the ground field. This book presupposes knowledge of classical Galois theory and the attendant algebra. Before considering questions of reducing the embedding problems and reformulating the solvability criteria, the

  12. Facts about Type 2

    Medline Plus

    Full Text Available ... the Living WIth Type 2 Diabetes Program Gestational What is Gestational Diabetes? How to Treat Gestational Diabetes Genetics of Diabetes Diabetes Myths A Day in the Life of Diabetes Famous People Working to Stop Diabetes Common Terms Diabetes Statistics Infographics ...

  13. Facts about Type 2

    Medline Plus

    Full Text Available ... diabetes. » « Connect With Us Register for diabetes news, research and food & fitness tips. Email: Sign Up Thank you for ... Living WIth Type 2 Diabetes Program Food & Fitness Food Recipes Planning ... to Congress Research & Practice We Are Research Leaders We Support Your ...

  14. Facts about Type 2

    Medline Plus

    Full Text Available ... Risk? Home Prevention Diagnosing Diabetes and Learning About Prediabetes Type 2 Diabetes Risk Test Lower Your Risk ... Chat Closed engagement en -- So…Do You Have Prediabetes? - 2017-01-ad-council.html So…Do You ...

  15. Type VI secretion system.

    Science.gov (United States)

    Salomon, Dor; Orth, Kim

    2015-03-30

    Bacteria employ a variety of tools to survive in a competitive environment. Salomon and Orth describe one such tool-the Type 6 Secretion Systems used by bacteria to deliver a variety of toxins into competing cells. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. Facts about Type 2

    Medline Plus

    Full Text Available ... Are Research Leaders World's Largest Diabetes Meeting Recent Advances Type 1 Research Highlights Research Excellence Honorees How ... you for signing up ' + ' '); $('.survey-form').show(); }, success: function (data) { $('#survey-errors').remove(); $('.survey-form .form-group . ...

  17. Chemistry of Blood Type

    Science.gov (United States)

    Coleman, William F.

    2005-01-01

    The molecule of December 2005 comes from the paper by Rose, Palcic and Evans on structural factors determining the blood type. The structure was previously reported by Palcic and Evans and is presented without the water molecule that is determined in the crystal structure.

  18. Facts about Type 2

    Medline Plus

    Full Text Available ... Care Blood Glucose Testing Medication Doctors, Nurses & More Oral Health & Hygiene Women A1C Insulin Pregnancy 8 Tips for ... But, your doctor may need to also prescribe oral medications or insulin to help you meet your target blood glucose levels. Type 2 usually gets ... Health Advisor Tools to Know Your Risk Diabetes Basics ...

  19. Facts about Type 2

    Medline Plus

    Full Text Available ... Diabetes Meal Plans Create Your Plate Gluten Free Diets Meal Planning for Vegetarian Diets Cook with Heart-Healthy Foods Holiday Meal Planning ... Index Low-Calorie Sweeteners Sugar and Desserts Fitness Exercise & Type 1 Diabetes Get Started Safely Get And ...

  20. Facts about Type 2

    Medline Plus

    Full Text Available ... Gift Fundraising Events Donate Stocks Give by Phone 1-800-DIABETES (800-342-2383) Give by ... 2 diabetes is the most common form of diabetes. In type 2 diabetes, your body does not use insulin properly. This is called insulin resistance. At first, ...

  1. Facts about Type 2

    Medline Plus

    Full Text Available ... first, you may need to later on. Some groups have a higher risk for developing type 2 ... function (data) { $('#survey-errors').remove(); $('.survey-form .form-group .survey-alert-wrap').remove(); if (data.submitSurveyResponse.success == ' ...

  2. TypeScript essentials

    CERN Document Server

    Nance, Christopher

    2014-01-01

    The book introduces the TypeScript language and its features to anyone looking to develop rich web applications. Whether you are new to web development or are an experienced engineer with strong JavaScript skills, this book will get you writing code quickly. A basic understanding of JavaScript and its language features are necessary for this book.

  3. Facts about Type 2

    Medline Plus

    Full Text Available ... Diabetes Research & Practice Home We Are Research Leaders World's Largest Diabetes Meeting Recent Advances Type 1 Research ... survey-loading').remove(); $('#emailsurvey').hide(); $('#emailsurveythanks').show(); } } }; /* bind any forms with the "luminateApi" class */ luminateExtend.api.bind(); }); })( ...

  4. [Enterocin typing of enterococci].

    Science.gov (United States)

    Sedov, V I

    1978-09-01

    The author worked out a method of enterocinotyping on enterococci. A possibility of enterococcus typing by means of a set of enterocinogenic enterococcus strains was shown. A mobile enterococcus 4 (10 p) strain, possessing a high antagonistic activity, is suggested for enterococcus identification. Differentiation of enterococcus species by the enterocine sensitivity proved to be impossible.

  5. Facts about Type 2

    Medline Plus

    Full Text Available ... Diabetes causes more deaths a year than breast cancer and AIDS combined. Your gift today will help us get closer to ... normal. Type 2 is treated with lifestyle changes, oral medications (pills), and insulin. When glucose builds up ...

  6. Facts about Type 2

    Medline Plus

    Full Text Available ... You At Risk? Diabetes Basics Living with Diabetes Food & Fitness In My Community Advocacy Research & Practice Ways to Give Close Are You at Risk? ... Living WIth Type 2 Diabetes Program Food & Fitness Food Recipes Planning ... Congress Research & Practice We Are Research Leaders We Support Your Doctor ...

  7. Facts about Type 2

    Medline Plus

    Full Text Available ... Superfoods Non-starchy Vegetables Grains and Starchy Vegetables Fats Alcohol What Can I Drink? Fruit Dairy Food Tips Eating Out Quick Meal Ideas Snacks Nutrient Content Claims Understanding Carbohydrates Types of Carbohydrates Carbohydrate Counting Make Your Carbs Count ...

  8. Facts about Type 2

    Medline Plus

    Full Text Available ... August 1, 2013 Last Edited: October 27, 2015 Articles from Diabetes Forecast® magazine: lp-type-2, . In ... today and help fund grants supporting next generation scientists. Donate Today We Can Help - we-can-help. ...

  9. Facts about Type 2

    Medline Plus

    Full Text Available ... can’t make enough insulin to keep your blood glucose levels normal. Type 2 is treated with lifestyle changes, ... may be starved for energy. Over time, high blood glucose levels may hurt your eyes, kidneys, nerves or heart. ...

  10. Facts about Type 2

    Medline Plus

    Full Text Available ... Diabetes causes more deaths a year than breast cancer and AIDS combined. Your gift today will help us get closer ... time, high blood glucose levels may hurt your eyes, kidneys, nerves or heart. Some people with type 2 ...

  11. Facts about Type 2

    Medline Plus

    Full Text Available ... You at Risk? Home Prevention Diagnosing Diabetes and Learning About Prediabetes Type 2 Diabetes Risk Test Lower Your Risk Healthy Eating Overweight Smoking High Blood Pressure Physical Activity High Blood Glucose My Health Advisor Tools To Know Your Risk Alert Day Diabetes Basics ...

  12. Facts about Type 2

    Medline Plus

    Full Text Available ... 1 Type 2 About Us Online Community Meal Planning Sign In Search: Search More Sites Search ≡ Are ... Fitness Home Food MyFoodAdvisor Recipes Association Cookbook Recipes Planning Meals Diabetes Meal Plans Create Your Plate Gluten ...

  13. Facts about Type 2

    Medline Plus

    Full Text Available ... and Pacific Islanders American Indian/Alaska Native Programs Older Adults Family Link Diabetes EXPO Upcoming Diabetes EXPOs EXPO ... Asian Americans/Pacific Islanders, as well as the aged population. Patient Education Materials — Taking Care of Type 2 Diabetes This ... Health Advisor Tools to Know Your Risk Diabetes Basics ...

  14. Facts about Type 2

    Medline Plus

    Full Text Available ... You At Risk? Diabetes Basics Living with Diabetes Food & Fitness In My Community Advocacy Research & Practice Ways to Give Close Are You at Risk? Home Prevention Diagnosing Diabetes and Learning About Prediabetes Type 2 Diabetes Risk Test Lower Your Risk Healthy Eating Overweight Smoking High ...

  15. Facts about Type 2

    Medline Plus

    Full Text Available ... Diabetes Research & Practice Home We Are Research Leaders World's Largest Diabetes Meeting Recent Advances Type 1 Research Highlights Research Excellence Honorees How We Fund Research Funding the Next Generation of Brilliant Researchers Diabetes Pro: Professional Resources Online We Support Your ...

  16. Facts about Type 2

    Medline Plus

    Full Text Available ... isn’t able to keep up and can’t make enough insulin to keep your blood glucose levels normal. Type 2 is treated with lifestyle changes, oral medications (pills), and insulin. When glucose builds up in the blood instead of going into cells, it can cause two problems: Right away, your ...

  17. Compositional data types

    DEFF Research Database (Denmark)

    Bahr, Patrick; Hvitved, Tom

    2011-01-01

    -cut fusion style deforestation which yields considerable speedups. We demonstrate our framework in the setting of compiler construction, and moreover, we compare compositional data types with generic programming techniques and show that both are comparable in run-time performance and expressivity while our...

  18. Facts about Type 2

    Medline Plus

    Full Text Available ... News & Events Advocacy News Call to Congress The Cost of Diabetes Research & Practice Home We Are Research Leaders World's Largest Diabetes Meeting Recent Advances Type 1 Research Highlights Research Excellence Honorees How We Fund Research Funding the Next Generation of Brilliant Researchers ...

  19. Facts about Type 2

    Medline Plus

    Full Text Available ... Diets Cook with Heart-Healthy Foods Holiday Meal Planning What Can I Eat? Making Healthy Food Choices Diabetes ... Type 2 Diabetes Program Food & Fitness Food Recipes Planning Meals What Can I Eat Weight Loss Fitness In My ...

  20. Type 1 narcolepsy

    DEFF Research Database (Denmark)

    Degn, Matilda; Kornum, Birgitte Rahbek

    2015-01-01

    Type 1 narcolepsy is a sleep disorder characterized by excessive daytime sleepiness with unintentional sleep attacks and cataplexy. The disorder is caused by a loss of hypocretinergic neurons in the brain. The specific loss of these neurons in narcolepsy is thought to result from an autoimmune...

  1. Type B drum packages

    International Nuclear Information System (INIS)

    McCoy, J.C.

    1994-08-01

    The Type B drum packages (TBD) are conceptualized as a family of containers in which a single 208 L or 114 L (55 gal or 30 gal) drum containing Type B quantities of radioactive material (RAM) can be packaged for shipment. The TBD containers are being developed to fill a void in the packaging and transportation capabilities of the U.S. Department of Energy as no container packaging single drums of Type B RAM exists offering double containment. Several multiple-drum containers currently exist, as well as a number of shielded casks, but the size and weight of these containers present many operational challenges for single-drum shipments. As an alternative, the TBD containers will offer up to three shielded versions (light, medium, and heavy) and one unshielded version, each offering single or optional double containment for a single drum. To reduce operational complexity, all versions will share similar design and operational features where possible. The primary users of the TBD containers are envisioned to be any organization desiring to ship single drums of Type B RAM, such as laboratories, waste retrieval activities, emergency response teams, etc. Currently, the TBD conceptual design is being developed with the final design and analysis to be completed in 1995 to 1996. Testing and certification of the unshielded version are planned to be completed in 1996 to 1997 with production to begin in 1997 to 1998

  2. Facts about Type 2

    Medline Plus

    Full Text Available ... for Association Events Messaging Tools Recruiting Advocates Local Market Planning Training Webinars News & Events Advocacy News Call to Congress The Cost of Diabetes Research & Practice Home We Are Research Leaders World's Largest Diabetes Meeting Recent Advances Type 1 ...

  3. Facts about Type 2

    Medline Plus

    Full Text Available ... Complications Neuropathy Foot Complications DKA (Ketoacidosis) & Ketones Kidney Disease (Nephropathy) Gastroparesis Mental Health Step On Up Treatment & ... Non-starchy Vegetables Grains and Starchy ... form of diabetes. In type 2 diabetes, your body does not use insulin properly. This is called insulin resistance. At ...

  4. Facts about Type 2

    Medline Plus

    Full Text Available ... Last Edited: October 27, 2015 Articles from Diabetes Forecast® magazine: lp-type-2, . In this section Diabetes ... Use and Privacy Policy « American Diabetes Association Diabetes Forecast Stop Diabetes Step Out: Walk to Stop Diabetes ...

  5. Facts about Type 2

    Medline Plus

    Full Text Available ... You At Risk? Diabetes Basics Living with Diabetes Food & Fitness In My Community Advocacy Research & Practice Ways to Give Close Are You at ... Living WIth Type 2 Diabetes Program Food & Fitness Food Recipes Planning ... to Congress Research & Practice We Are Research Leaders We Support Your ...

  6. Type Inference for Session Types in the Pi-Calculus

    DEFF Research Database (Denmark)

    Graversen, Eva Fajstrup; Harbo, Jacob Buchreitz; Huttel, Hans

    2014-01-01

    In this paper we present a direct algorithm for session type inference for the π-calculus. Type inference for session types has previously been achieved by either imposing limitations and restriction on the π-calculus, or by reducing the type inference problem to that for linear types. Our approach...

  7. Types of planetary tori

    International Nuclear Information System (INIS)

    Huang, T.S.; Siscoe, G.L.

    1987-01-01

    While satellite tori are morphologically similar, they divide into dynamically distinct groups whose global balances of ions and neutrals are presently modeled in order to determine how a torus behaves as a consequence of whether it generates itself and whether it disperses or recombines in place. Six possible types of behavior result; attention is given to the equilibrium and stability of each type. The behavior of a perturbation is characterized by a trajectory in the two-dimensional space formed by the ion density and neutral density perturbations. The equilibrium is stable if a perturbation follows its trajectory toward the origin, but is unstable if the motion is away from it. An attempt is made to classify the Jupiter and Saturn tori in this light. 27 references

  8. Types, typologies, arguments

    OpenAIRE

    Plantin, Christian

    2017-01-01

    The concept of arguments schemes is fundamental for argumentation studies; but its implementation is not obvious. The first section of this contribution briefly starts from the concepts of argument scheme, typology of arguments schemes, and the foundational catalogue of 28 topoi from Aristotle's Rhetoric. The application of the "topical method" is first based on the knowledge of typologies of arguments, and then on the precise features defining an argument type. The practical question that re...

  9. Contract types - turnkey

    International Nuclear Information System (INIS)

    Loeffler, G.

    1975-01-01

    Turnkey or the turnkey type of contract refers to a system of management according to which one organization accepts total responsibility for completing all parts and all phases of a project. In the case of a power project the turnkey contractor undertakes to design the plant, supply or procure and erect the equipment, build the station and put it into operation. (orig./FW) [de

  10. Nuclear reactor types

    International Nuclear Information System (INIS)

    Jones, P.M.S.

    1987-01-01

    The characteristics of different reactor types designed to exploit controlled fission reactions are explained. Reactors vary from low power research devices to high power devices especially designed to produce heat, either for direct use or to produce steam to drive turbines to generate electricity or propel ships. A general outline of basic reactors (thermal and fast) is given and then the different designs considered. The first are gas cooled, including the Magnox reactors (a list of UK Magnox stations and reactor performance is given), advanced gas cooled reactors (a list of UK AGRs is given) and the high temperature reactor. Light water cooled reactors (pressurized water [PWR] and boiling water [BWR] reactors) are considered next. Heavy water reactors are explained and listed. The pressurized heavy water reactors (including CANDU type reactors), boiling light water, steam generating heavy water reactors and gas cooled heavy water reactors all come into this category. Fast reactors (liquid metal fast breeder reactors and gas cooled fast reactors) and then water-cooled graphite-moderated reactors (RBMK) (the type at Chernobyl-4) are discussed. (U.K.)

  11. Tank type reactor

    International Nuclear Information System (INIS)

    Otsuka, Fumio.

    1989-01-01

    The present invention concerns a tank type reactor capable of securing reactor core integrity by preventing incorporation of gases to an intermediate heat exchanger, thgereby improving the reliability. In a conventional tank type reactor, since vortex flows are easily caused near the inlet of an intermediate heat exchanger, there is a fear that cover gases are involved into the coolant main streams to induce fetal accidents. In the present invention, a reactor core is suspended by way of a suspending body to the inside of a reactor vessel and an intermediate heat exchanger and a pump are disposed between the suspending body and the reactor vessel, in which a vortex current preventive plate is attached at the outside near the coolant inlet on the primary circuit of the intermediate heat exchanger. In this way vortex or turbulence near the inlet of the intermediate heata exchanger or near the surface of coolants can be prevented. Accordingly, the cover gases are no more involved, to insure the reactor core integrity and obtain a tank type nuclear reactor of high reliability. (I.S.)

  12. Type Families with Class, Type Classes with Family

    DEFF Research Database (Denmark)

    Serrano, Alejandro; Hage, Jurriaan; Bahr, Patrick

    2015-01-01

    Type classes and type families are key ingredients in Haskell programming. Type classes were introduced to deal with ad-hoc polymorphism, although with the introduction of functional dependencies, their use expanded to type-level programming. Type families also allow encoding type-level functions......, now as rewrite rules. This paper looks at the interplay of type classes and type families, and how to deal with shortcomings in both of them. Furthermore, we show how to use families to simulate classes at the type level. However, type families alone are not enough for simulating a central feature...... of type classes: elaboration, that is, generating code from the derivation of a rewriting. We look at ways to solve this problem in current Haskell, and propose an extension to allow elaboration during the rewriting phase....

  13. Play the Blood Typing Game

    Science.gov (United States)

    ... Nobel's Life and Work Teachers' Questionnaire The Blood Typing Game What happens if you get a blood ... learn about human blood types! Play the Blood Typing Game 28 September 2017 The mission based game ...

  14. Type 1 autoimmune pancreatitis.

    Science.gov (United States)

    Zen, Yoh; Bogdanos, Dimitrios P; Kawa, Shigeyuki

    2011-12-07

    Before the concept of autoimmune pancreatitis (AIP) was established, this form of pancreatitis had been recognized as lymphoplasmacytic sclerosing pancreatitis or non-alcoholic duct destructive chronic pancreatitis based on unique histological features. With the discovery in 2001 that serum IgG4 concentrations are specifically elevated in AIP patients, this emerging entity has been more widely accepted. Classical cases of AIP are now called type 1 as another distinct subtype (type 2 AIP) has been identified. Type 1 AIP, which accounts for 2% of chronic pancreatitis cases, predominantly affects adult males. Patients usually present with obstructive jaundice due to enlargement of the pancreatic head or thickening of the lower bile duct wall. Pancreatic cancer is the leading differential diagnosis for which serological, imaging, and histological examinations need to be considered. Serologically, an elevated level of IgG4 is the most sensitive and specific finding. Imaging features include irregular narrowing of the pancreatic duct, diffuse or focal enlargement of the pancreas, a peri-pancreatic capsule-like rim, and enhancement at the late phase of contrast-enhanced images. Biopsy or surgical specimens show diffuse lymphoplasmacytic infiltration containing many IgG4+ plasma cells, storiform fibrosis, and obliterative phlebitis. A dramatic response to steroid therapy is another characteristic, and serological or radiological effects are normally identified within the first 2 or 3 weeks. Type 1 AIP is estimated as a pancreatic manifestation of systemic IgG4-related disease based on the fact that synchronous or metachronous lesions can develop in multiple organs (e.g. bile duct, salivary/lacrimal glands, retroperitoneum, artery, lung, and kidney) and those lesions are histologically identical irrespective of the organ of origin. Several potential autoantigens have been identified so far. A Th2-dominant immune reaction and the activation of regulatory T-cells are assumed

  15. Type 1 autoimmune pancreatitis

    Directory of Open Access Journals (Sweden)

    Zen Yoh

    2011-12-01

    Full Text Available Abstract Before the concept of autoimmune pancreatitis (AIP was established, this form of pancreatitis had been recognized as lymphoplasmacytic sclerosing pancreatitis or non-alcoholic duct destructive chronic pancreatitis based on unique histological features. With the discovery in 2001 that serum IgG4 concentrations are specifically elevated in AIP patients, this emerging entity has been more widely accepted. Classical cases of AIP are now called type 1 as another distinct subtype (type 2 AIP has been identified. Type 1 AIP, which accounts for 2% of chronic pancreatitis cases, predominantly affects adult males. Patients usually present with obstructive jaundice due to enlargement of the pancreatic head or thickening of the lower bile duct wall. Pancreatic cancer is the leading differential diagnosis for which serological, imaging, and histological examinations need to be considered. Serologically, an elevated level of IgG4 is the most sensitive and specific finding. Imaging features include irregular narrowing of the pancreatic duct, diffuse or focal enlargement of the pancreas, a peri-pancreatic capsule-like rim, and enhancement at the late phase of contrast-enhanced images. Biopsy or surgical specimens show diffuse lymphoplasmacytic infiltration containing many IgG4+ plasma cells, storiform fibrosis, and obliterative phlebitis. A dramatic response to steroid therapy is another characteristic, and serological or radiological effects are normally identified within the first 2 or 3 weeks. Type 1 AIP is estimated as a pancreatic manifestation of systemic IgG4-related disease based on the fact that synchronous or metachronous lesions can develop in multiple organs (e.g. bile duct, salivary/lacrimal glands, retroperitoneum, artery, lung, and kidney and those lesions are histologically identical irrespective of the organ of origin. Several potential autoantigens have been identified so far. A Th2-dominant immune reaction and the activation of

  16. Type 2 diabetes mellitus

    DEFF Research Database (Denmark)

    DeFronzo, Ralph A; Ferrannini, Ele; Groop, Leif

    2015-01-01

    Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular complications (including retinopathy, nephropathy and neuropathy) and macrovascular complications (such as cardiovascular...... that multiple antidiabetic agents, used in combination, will be required to maintain normoglycaemia. The treatment must not only be effective and safe but also improve the quality of life. Several novel medications are in development, but the greatest need is for agents that enhance insulin sensitivity, halt...

  17. Tension-type headache

    DEFF Research Database (Denmark)

    Bendtsen, Lars; Jensen, Rigmor; Bendtsen, Lars

    2009-01-01

    The substantial societal and individual burdens associated with tension-type headache (TTH) constitute a previously overlooked major public health issue. TTH is prevalent, affecting up to 78% of the general population, and 3% suffer from chronic TTH. Pericranial myofascial nociception probably...... is important for the pathophysiology of episodic TTH, whereas sensitization of central nociceptive pathways seems responsible for the conversion of episodic to chronic TTH. Headache-related disability usually can be reduced by identification of trigger factors combined with nonpharmacologic and pharmacologic...... treatments, but effective treatment modalities are lacking. Benefits can be gained by development of specific and effective treatment strategies....

  18. Desmoid-type fibromatosis

    International Nuclear Information System (INIS)

    Otero, S.; Moskovic, E.C.; Strauss, D.C.; Benson, C.; Miah, A.B.; Thway, K.; Messiou, C.

    2015-01-01

    Desmoid-type fibromatosis is a rare, locally infiltrative, mesenchymal neoplasm that is associated with high rates of local recurrence but lacks the potential to metastasise. The disease affects younger individuals, with a peak age of 30 years, and is the most common cause of an anterior abdominal wall mass in young women of childbearing age. It may, however, involve nearly every body part, including the extremities, head and neck, trunk, and abdominal cavity; as such, desmoid-type fibromatosis may present to a range of general and subspecialty radiologists. These rare tumours have a widely variable clinical presentation and unpredictable natural history, hence input from a soft-tissue tumour centre is recommended, although much of the imaging may be performed at the patient's local hospital. The consensus for treatment has changed over the past decade, with most centres moving away from primary radical surgery towards a front-line ‘watch-and-wait’ policy. Therefore, imaging has an increasingly important role to play in both the diagnosis and follow-up of these patients. This review will discuss the typical imaging characteristics of these lesions and suggest diagnostic and follow-up magnetic resonance imaging protocols, with details of suitable sequences and scanning intervals

  19. BWR type nuclear reactors

    International Nuclear Information System (INIS)

    Yamamoto, Toru.

    1987-01-01

    Purpose: To obtain reactor core characteristics with less changes in the excess reactivity due to fuel burnup even when the operation period varies. Constitution: In a BWR type reactor where fuel assemblies containing fuel rods incorporated with burnable poisons are arranged, the fuel assemblies are grouped into first fuel assemblies and second fuel assemblies. Then, the number of fuel rods incorporated with burnable poisons within the first fuel assemblies is made greater than that of the second fuel rods, while the concentration of the burnable poisons in the fuel rods incorporated with the burnable poisons in the first fuel assemblies is made lower than that of the fuel rods incorporated with the burnable poisons in the second fuel assemblies. In the BWR type reactor constituted in this way, the reactor core characteristics can be improved by changing the ratio between the first fuel assemblies and the second fuel assemblies charged to the reactor core, thereby decreasing the changes in the burnup of the excess reactivity. (Kamimura, M.)

  20. Stack semantics of type theory

    DEFF Research Database (Denmark)

    Coquand, Thierry; Mannaa, Bassel; Ruch, Fabian

    2017-01-01

    We give a model of dependent type theory with one univalent universe and propositional truncation interpreting a type as a stack, generalizing the groupoid model of type theory. As an application, we show that countable choice cannot be proved in dependent type theory with one univalent universe...