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Sample records for ras design simulation

  1. Analog reactor simulator RAS; Reaktorski analogni simulator RAS

    Energy Technology Data Exchange (ETDEWEB)

    Radanovic, Lj; Bingulac, S; Popovic, D [The Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Yugoslavia)

    1961-07-01

    Analog computer RAS was designed as a nuclear reactor simulator, but it can be simultaneously used for solving a number of other problems. This paper contains a brief description of the simulator parts and their principal characteristics.

  2. Ras conformational switching: simulating nucleotide-dependent conformational transitions with accelerated molecular dynamics.

    Directory of Open Access Journals (Sweden)

    Barry J Grant

    2009-03-01

    Full Text Available Ras mediates signaling pathways controlling cell proliferation and development by cycling between GTP- and GDP-bound active and inactive conformational states. Understanding the complete reaction path of this conformational change and its intermediary structures is critical to understanding Ras signaling. We characterize nucleotide-dependent conformational transition using multiple-barrier-crossing accelerated molecular dynamics (aMD simulations. These transitions, achieved for the first time for wild-type Ras, are impossible to observe with classical molecular dynamics (cMD simulations due to the large energetic barrier between end states. Mapping the reaction path onto a conformer plot describing the distribution of the crystallographic structures enabled identification of highly populated intermediate structures. These structures have unique switch orientations (residues 25-40 and 57-75 intermediate between GTP and GDP states, or distinct loop3 (46-49, loop7 (105-110, and alpha5 C-terminus (159-166 conformations distal from the nucleotide-binding site. In addition, these barrier-crossing trajectories predict novel nucleotide-dependent correlated motions, including correlations of alpha2 (residues 66-74 with alpha3-loop7 (93-110, loop2 (26-37 with loop10 (145-151, and loop3 (46-49 with alpha5 (152-167. The interconversion between newly identified Ras conformations revealed by this study advances our mechanistic understanding of Ras function. In addition, the pattern of correlated motions provides new evidence for a dynamic linkage between the nucleotide-binding site and the membrane interacting C-terminus critical for the signaling function of Ras. Furthermore, normal mode analysis indicates that the dominant collective motion that occurs during nucleotide-dependent conformational exchange, and captured in aMD (but absent in cMD simulations, is a low-frequency motion intrinsic to the structure.

  3. Flood Zoning Simulation by HEC-RAS Model (Case Study: Johor River-Kota Tinggi Region)

    OpenAIRE

    ShahiriParsa, Ahmad; Heydari, Mohammad; Sadeghian, Mohammad Sadegh; Moharrampour, Mahdi

    2015-01-01

    Flooding of rivers has caused many human and financial losses. Hence, studies and research on the nature of the river is inevitable.However, the behavior of rivers hasmany complexities and in this respect, computer models are efficient tools in order to study and simulate the behavior of rivers with the least possible cost. In this paper, one-dimensional model HEC-RAS was used to simulate the flood zoning in the Kota Tinggi district in Johor state. Implementation processes of the zoning on ca...

  4. RAS Insight

    Science.gov (United States)

    David Heimbrook, now CEO of the Frederick National Laboratory for Cancer Research, played a major role in a large pharma as it tried to develop an anti-RAS drug. Lessons from that failure inform the RAS Initiative today.

  5. Technique for Simulation of Black Sea Circulation with Increased Resolution in the Area of the IO RAS Polygon

    Science.gov (United States)

    Gusev, A. V.; Zalesny, V. B.; Fomin, V. V.

    2017-11-01

    A numerical technique is presented for simulating the hydrophysical fields of the Black Sea on a variable-step grid with refinement in the area of IO RAS polygon. Model primitive equations are written in spherical coordinates with an arbitrary arrangement of poles. In order to increase the horizontal resolution of the coastal zone in the area of the IO RAS polygon in the northeastern part of the sea near Gelendzhik, one of the poles is placed at a land point (38.35° E, 44.75° N). The model horizontal resolution varies from 150 m in the area of the IO RAS polygon to 4.6 km in the southwestern part of the Black Sea. The numerical technique makes it possible to simulate a large-scale structure of Black Sea circulation as well as the meso- and submesoscale dynamics of the coastal zone. In order to compute the atmospheric forcing, the results of the regional climate model WRF with a resolution of about 10 km in space and 1 h in time are used. In order to demonstrate the technique, Black Sea hydrophysical fields for 2011-2012 and a passive tracer transport representing self-cleaning of Gelendzhik Bay in July 2012 are simulated.

  6. An innovative modeling approach using Qual2K and HEC-RAS integration to assess the impact of tidal effect on River Water quality simulation.

    Science.gov (United States)

    Fan, Chihhao; Ko, Chun-Han; Wang, Wei-Shen

    2009-04-01

    Water quality modeling has been shown to be a useful tool in strategic water quality management. The present study combines the Qual2K model with the HEC-RAS model to assess the water quality of a tidal river in northern Taiwan. The contaminant loadings of biochemical oxygen demand (BOD), ammonia nitrogen (NH(3)-N), total phosphorus (TP), and sediment oxygen demand (SOD) are utilized in the Qual2K simulation. The HEC-RAS model is used to: (i) estimate the hydraulic constants for atmospheric re-aeration constant calculation; and (ii) calculate the water level profile variation to account for concentration changes as a result of tidal effect. The results show that HEC-RAS-assisted Qual2K simulations taking tidal effect into consideration produce water quality indices that, in general, agree with the monitoring data of the river. Comparisons of simulations with different combinations of contaminant loadings demonstrate that BOD is the most import contaminant. Streeter-Phelps simulation (in combination with HEC-RAS) is also performed for comparison, and the results show excellent agreement with the observed data. This paper is the first report of the innovative use of a combination of the HEC-RAS model and the Qual2K model (or Streeter-Phelps equation) to simulate water quality in a tidal river. The combination is shown to provide an alternative for water quality simulation of a tidal river when available dynamic-monitoring data are insufficient to assess the tidal effect of the river.

  7. Design of fault simulator

    Energy Technology Data Exchange (ETDEWEB)

    Gabbar, Hossam A. [Faculty of Energy Systems and Nuclear Science, University of Ontario Institute of Technology (UOIT), Ontario, L1H 7K4 (Canada)], E-mail: hossam.gabbar@uoit.ca; Sayed, Hanaa E.; Osunleke, Ajiboye S. [Okayama University, Graduate School of Natural Science and Technology, Division of Industrial Innovation Sciences Department of Intelligent Systems Engineering, Okayama 700-8530 (Japan); Masanobu, Hara [AspenTech Japan Co., Ltd., Kojimachi Crystal City 10F, Kojimachi, Chiyoda-ku, Tokyo 102-0083 (Japan)

    2009-08-15

    Fault simulator is proposed to understand and evaluate all possible fault propagation scenarios, which is an essential part of safety design and operation design and support of chemical/production processes. Process models are constructed and integrated with fault models, which are formulated in qualitative manner using fault semantic networks (FSN). Trend analysis techniques are used to map real time and simulation quantitative data into qualitative fault models for better decision support and tuning of FSN. The design of the proposed fault simulator is described and applied on experimental plant (G-Plant) to diagnose several fault scenarios. The proposed fault simulator will enable industrial plants to specify and validate safety requirements as part of safety system design as well as to support recovery and shutdown operation and disaster management.

  8. Estimating design flood and HEC-RAS modelling approach for flood analysis in Bojonegoro city

    Science.gov (United States)

    Prastica, R. M. S.; Maitri, C.; Hermawan, A.; Nugroho, P. C.; Sutjiningsih, D.; Anggraheni, E.

    2018-03-01

    Bojonegoro faces flood every year with less advanced prevention development. Bojonegoro city development could not peak because the flood results material losses. It affects every sectors in Bojonegoro: education, politics, economy, social, and infrastructure development. This research aims to analyse and to ensure that river capacity has high probability to be the main factor of flood in Bojonegoro. Flood discharge analysis uses Nakayasu synthetic unit hydrograph for period of 5 years, 10 years, 25 years, 50 years, and 100 years. They would be compared to the water maximum capacity that could be loaded by downstream part of Bengawan Solo River in Bojonegoro. According to analysis result, Bengawan Solo River in Bojonegoro could not able to load flood discharges. Another method used is HEC-RAS analysis. The conclusion that shown by HEC-RAS analysis has the same view. It could be observed that flood water loading is more than full bank capacity elevation in the river. To conclude, the main factor that should be noticed by government to solve flood problem is river capacity.

  9. The RAS Initiative

    Science.gov (United States)

    NCI established the RAS Initiative to explore innovative approaches for attacking the proteins encoded by mutant forms of RAS genes and to ultimately create effective, new therapies for RAS-related cancers.

  10. Design and realization of simulators

    International Nuclear Information System (INIS)

    Mathey, C.

    1984-01-01

    The two main categories of simulators are training simulators of which aim is the education of the nuclear power plant operators, and the study simulators. The French park of simulators is reviewed, as also their field of utilization. One deals with the simulator design: general description, calculation tools, middleware, and programming, mathematical models and numerical methods. Then, the instructor post of the EDF's simulators are more particularly described. The realization of a simulator includes two main stages: the development of the material and, the development of the software [fr

  11. Inhibitors of Ras-SOS Interactions.

    Science.gov (United States)

    Lu, Shaoyong; Jang, Hyunbum; Zhang, Jian; Nussinov, Ruth

    2016-04-19

    Activating Ras mutations are found in about 30 % of human cancers. Ras activation is regulated by guanine nucleotide exchange factors, such as the son of sevenless (SOS), which form protein-protein interactions (PPIs) with Ras and catalyze the exchange of GDP by GTP. This is the rate-limiting step in Ras activation. However, Ras surfaces lack any evident suitable pockets where a molecule might bind tightly, rendering Ras proteins still 'undruggable' for over 30 years. Among the alternative approaches is the design of inhibitors that target the Ras-SOS PPI interface, a strategy that is gaining increasing recognition for treating Ras mutant cancers. Herein we focus on data that has accumulated over the past few years pertaining to the design of small-molecule modulators or peptide mimetics aimed at the interface of the Ras-SOS PPI. We emphasize, however, that even if such Ras-SOS therapeutics are potent, drug resistance may emerge. To counteract this development, we propose "pathway drug cocktails", that is, drug combinations aimed at parallel (or compensatory) pathways. A repertoire of classified cancer, cell/tissue, and pathway/protein combinations would be beneficial toward this goal. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Effects of Land Use Changes on the Runoff in the Landscape Based on Hydrological Simulation in HEC-HMS and HEC-RAS Using Different Elevation Data

    Directory of Open Access Journals (Sweden)

    Josef Divín

    2016-01-01

    Full Text Available The aim of this paper is to determine the effects of land use changes on the runoff in the landscape by means of hydrological modelling. Our partial aim is also to determine the effect of different elevation data and define optimal data sources for this modelling. The research was conducted on the Starozuberský stream experimental watershed. For comparing elevation models, three scenarios were developed with different input data. Based on a comparison of these models an optimal data source for hydrological modelling was selected. To simulate the change in land use, we have created two scenarios based either upon the current land use and historical data from the fifties of the twentieth century. Comparison was carried out using the HEC-HMS software interface for rainfall-runoff simulation and HEC-RAS for the flooding simulation. Data for the simulation were prepared using the ESRI ArcGIS extensions, namely HEC- GeoHMS and HEC-GeoRAS.

  13. Design education with simulation games

    DEFF Research Database (Denmark)

    Juuti, Tero; Lehtonen, Timo; Hansen, Poul H. Kyvsgård

    2008-01-01

    " This paper is a report on the use of simulation games in design education. Our objective was to find solution to the question: "How to do design education effectively and efficiently for hundreds of people with minimum resources?" In the paper the learning theories are described in short. Our...... data was gathered from exams and the results were analysed. Especially the learning of low grade exam students was impressive when using simulation game. The data from industry is based on observations while using simulation game. The results were that each of the workshop, game, and simulation...... elements can support the effort if configured and synchronized properly. The simulation games are valuable method for design education with skillful design, scoping and facilitation."...

  14. Design automation, languages, and simulations

    CERN Document Server

    Chen, Wai-Kai

    2003-01-01

    As the complexity of electronic systems continues to increase, the micro-electronic industry depends upon automation and simulations to adapt quickly to market changes and new technologies. Compiled from chapters contributed to CRC's best-selling VLSI Handbook, this volume covers a broad range of topics relevant to design automation, languages, and simulations. These include a collaborative framework that coordinates distributed design activities through the Internet, an overview of the Verilog hardware description language and its use in a design environment, hardware/software co-design, syst

  15. Design of tool monitor simulator

    International Nuclear Information System (INIS)

    Yao Yonggang; Deng Changming; Zhang Jia; Meng Dan; Zhang Lu; Wang Zhi'ai; Shen Yang

    2011-01-01

    It is based on tool monitor in Qinshan Nuclear Power Plant for the object of study, and manufacture a tool monitor simulator. The device is designed to automatically emulate-monitor the contamination level of objects for training students. Once if the tool monitor reports the contamination, the students can handle properly. The brief introduction of main function and system design of the simulator are presented in the paper. (authors)

  16. RAS Initiative - Community Outreach

    Science.gov (United States)

    Through community and technical collaborations, workshops and symposia, and the distribution of reference reagents, the RAS Initiative seeks to increase the sharing of knowledge and resources essential to defeating cancers caused by mutant RAS genes.

  17. RAS Initiative - Events

    Science.gov (United States)

    The NCI RAS Initiative has organized multiple events with outside experts to discuss how the latest scientific and technological breakthroughs can be applied to discover vulnerabilities in RAS-driven cancers.

  18. About the RAS Initiative

    Science.gov (United States)

    The RAS Initiative, a "hub and spoke" model, connects researchers to better understand and target the more than 30% of cancers driven by mutations in RAS genes. Includes oversight and contact information.

  19. Genetic alterations in Ki-ras and Ha-ras genes in Juvenile Nasopharyngeal Angiofibromas and head and neck cancer

    Directory of Open Access Journals (Sweden)

    Cláudia Malheiros Coutinho

    1999-05-01

    Full Text Available CONETXT: Ras gene mutations have been associated to a wide range of human solid tumors. Members of the ras gene family (Ki-ras, Ha-ras and N-ras are structurally related and code for a protein (p21 known to play an important role in the regulation of normal signal transduction and cell growth. The frequency of ras mutations is different from one type of tumor to another, suggesting that point mutations might be carcinogen-specific. OBJECTIVES: To study the occurrence of Ki-ras and Ha-ras mutations. We also studied the relative level of Ha-ras mRNA in 32 of the head and neck tumors. DESIGN: Case series. SETTING: University referral unit. PARTICIPANTS: 60 head and neck tumors and in 28 Juvenile Nasopharyngeal Angiofibromas (JNA. DIAGNOSTIC TEST: Using PCR-SSCP we examined the occurrence of Ki-ras and Ha-ras mutations. The relative level of Ha-ras mRNA was examined by Northern blot analysis. RESULTS: None of the head and neck tumors or JNA samples showed evidence of mutations within codons 12, 13, 59 and 61 of Ki-ras or Ha-ras genes. However, 17 (53% of the tumors where gene expression could be examined exhibited increased levels of Ha-ras mRNA compared with the normal tissue derived from the same patient. CONCLUSIONS: Our results demonstrate for the first time that mutations of Ki-ras and Ha-ras genes are not associated with the development of JNA and confirm previous reports indicating that activating ras mutations are absent or rarely involved in head and neck tumors from western world patients. Furthermore, our findings suggest that overexpression of Ha-ras, rather than mutations, might be an important factor in the development and progression of head and neck tumors.

  20. RAS - Target Identification - Informatics

    Science.gov (United States)

    The RAS Informatics lab group develops tools to track and analyze “big data” from the RAS Initiative, as well as analyzes data from external projects. By integrating internal and external data, this group helps improve understanding of RAS-driven cancers.

  1. Design Techniques and Reservoir Simulation

    Directory of Open Access Journals (Sweden)

    Ahad Fereidooni

    2012-11-01

    Full Text Available Enhanced oil recovery using nitrogen injection is a commonly applied method for pressure maintenance in conventional reservoirs. Numerical simulations can be practiced for the prediction of a reservoir performance in the course of injection process; however, a detailed simulation might take up enormous computer processing time. In such cases, a simple statistical model may be a good approach to the preliminary prediction of the process without any application of numerical simulation. In the current work, seven rock/fluid reservoir properties are considered as screening parameters and those parameters having the most considerable effect on the process are determined using the combination of experimental design techniques and reservoir simulations. Therefore, the statistical significance of the main effects and interactions of screening parameters are analyzed utilizing statistical inference approaches. Finally, the influential parameters are employed to create a simple statistical model which allows the preliminary prediction of nitrogen injection in terms of a recovery factor without resorting to numerical simulations.

  2. High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.

    Science.gov (United States)

    Burns, Michael C; Howes, Jennifer E; Sun, Qi; Little, Andrew J; Camper, DeMarco V; Abbott, Jason R; Phan, Jason; Lee, Taekyu; Waterson, Alex G; Rossanese, Olivia W; Fesik, Stephen W

    2018-05-01

    K-RAS is mutated in approximately 30% of human cancers, resulting in increased RAS signaling and tumor growth. Thus, RAS is a highly validated therapeutic target, especially in tumors of the pancreas, lung and colon. Although directly targeting RAS has proven to be challenging, it may be possible to target other proteins involved in RAS signaling, such as the guanine nucleotide exchange factor Son of Sevenless (SOS). We have previously reported on the discovery of small molecules that bind to SOS1, activate SOS-mediated nucleotide exchange on RAS, and paradoxically inhibit ERK phosphorylation (Burns et al., PNAS, 2014). Here, we describe the discovery of additional, structurally diverse small molecules that also bind to SOS1 in the same pocket and elicit similar biological effects. We tested >160,000 compounds in a fluorescence-based assay to assess their effects on SOS-mediated nucleotide exchange. X-Ray structures revealed that these small molecules bind to the CDC25 domain of SOS1. Compounds that elicited high levels of nucleotide exchange activity in vitro increased RAS-GTP levels in cells, and inhibited phospho ERK levels at higher treatment concentrations. The identification of structurally diverse SOS1 binding ligands may assist in the discovery of new molecules designed to target RAS-driven tumors. Copyright © 2018 Elsevier Inc. All rights reserved.

  3. Simulation of a class of hazardous situations in the ICS «INM RAS - Baltic Sea»

    Science.gov (United States)

    Zakharova, Natalia; Agoshkov, Valery; Aseev, Nikita; Parmuzin, Eugene; Sheloput, Tateana; Shutyaev, Victor

    2017-04-01

    Development of Informational Computational Systems (ICS) for data assimilation procedures is one of multidisciplinary problems. To study and solve these problems one needs to apply modern results from different disciplines and recent developments in mathematical modeling, theory of adjoint equations and optimal control, inverse problems, numerical methods theory, numerical algebra, scientific computing and processing of satellite data. In this work the results on the ICS development for PC-ICS "INM RAS - Baltic Sea" are presented. We discuss practical problems studied by ICS. The System includes numerical model of the Baltic Sea thermodynamics, the new oil spill model describing the propagation of a slick at the Sea surface (Agoshkov, Aseev et al., 2014) and the optimal ship route calculating block (Agoshkov, Zayachkovsky et al., 2014). The ICS is based on the INMOM numerical model of the Baltic Sea thermodynamics (Zalesny et al., 2013). It is possible to calculate main hydrodynamic parameters (temperature, salinity, velocities, sea level) using user-friendly interface of the ICS. The System includes data assimilation procedures (Agoshkov, 2003, Parmuzin, Agoshkov, 2012) and one can use the block of variational assimilation of the sea surface temperature in order to obtain main hydrodynamic parameters. Main possibilities of the ICS and several numerical experiments are presented in the work. By the problem of risk control is meant a problem of determination of optimal resources quantity which are necessary for decreasing the risk to some acceptable value. Mass of oil slick is chosen as a function of control. For the realization of the random variable the quadratic "functional of cost" is introduced. It comprises cleaning costs and deviation of damage of oil pollution from its acceptable value. The problem of minimization of this functional is solved based on the methods of optimal control and the theory of adjoint equations. The solution of this problem is

  4. Xyce parallel electronic simulator design.

    Energy Technology Data Exchange (ETDEWEB)

    Thornquist, Heidi K.; Rankin, Eric Lamont; Mei, Ting; Schiek, Richard Louis; Keiter, Eric Richard; Russo, Thomas V.

    2010-09-01

    This document is the Xyce Circuit Simulator developer guide. Xyce has been designed from the 'ground up' to be a SPICE-compatible, distributed memory parallel circuit simulator. While it is in many respects a research code, Xyce is intended to be a production simulator. As such, having software quality engineering (SQE) procedures in place to insure a high level of code quality and robustness are essential. Version control, issue tracking customer support, C++ style guildlines and the Xyce release process are all described. The Xyce Parallel Electronic Simulator has been under development at Sandia since 1999. Historically, Xyce has mostly been funded by ASC, the original focus of Xyce development has primarily been related to circuits for nuclear weapons. However, this has not been the only focus and it is expected that the project will diversify. Like many ASC projects, Xyce is a group development effort, which involves a number of researchers, engineers, scientists, mathmaticians and computer scientists. In addition to diversity of background, it is to be expected on long term projects for there to be a certain amount of staff turnover, as people move on to different projects. As a result, it is very important that the project maintain high software quality standards. The point of this document is to formally document a number of the software quality practices followed by the Xyce team in one place. Also, it is hoped that this document will be a good source of information for new developers.

  5. Simulation of a Wall-Bounded Flow using a Hybrid LES/RAS Approach with Turbulence Recycling

    Science.gov (United States)

    Quinlan, Jesse R.; Mcdaniel, James; Baurle, Robert A.

    2012-01-01

    Simulations of a supersonic recessed-cavity flow are performed using a hybrid large-eddy/ Reynolds-averaged simulation approach utilizing an inflow turbulence recycling procedure and hybridized inviscid flux scheme. Calorically perfect air enters the three-dimensional domain at a free stream Mach number of 2.92. Simulations are performed to assess grid sensitivity of the solution, efficacy of the turbulence recycling, and effect of the shock sensor used with the hybridized inviscid flux scheme. Analysis of the turbulent boundary layer upstream of the rearward-facing step for each case indicates excellent agreement with theoretical predictions. Mean velocity and pressure results are compared to Reynolds-averaged simulations and experimental data for each case, and these comparisons indicate good agreement on the finest grid. Simulations are repeated on a coarsened grid, and results indicate strong grid density sensitivity. The effect of turbulence recycling on the solution is illustrated by performing coarse grid simulations with and without inflow turbulence recycling. Two shock sensors, one of Ducros and one of Larsson, are assessed for use with the hybridized inviscid flux reconstruction scheme.

  6. Sensitivity of Cirrus and Mixed-phase Clouds to the Ice Nuclei Spectra in McRAS-AC: Single Column Model Simulations

    Science.gov (United States)

    Betancourt, R. Morales; Lee, D.; Oreopoulos, L.; Sud, Y. C.; Barahona, D.; Nenes, A.

    2012-01-01

    The salient features of mixed-phase and ice clouds in a GCM cloud scheme are examined using the ice formation parameterizations of Liu and Penner (LP) and Barahona and Nenes (BN). The performance of LP and BN ice nucleation parameterizations were assessed in the GEOS-5 AGCM using the McRAS-AC cloud microphysics framework in single column mode. Four dimensional assimilated data from the intensive observation period of ARM TWP-ICE campaign was used to drive the fluxes and lateral forcing. Simulation experiments where established to test the impact of each parameterization in the resulting cloud fields. Three commonly used IN spectra were utilized in the BN parameterization to described the availability of IN for heterogeneous ice nucleation. The results show large similarities in the cirrus cloud regime between all the schemes tested, in which ice crystal concentrations were within a factor of 10 regardless of the parameterization used. In mixed-phase clouds there are some persistent differences in cloud particle number concentration and size, as well as in cloud fraction, ice water mixing ratio, and ice water path. Contact freezing in the simulated mixed-phase clouds contributed to transfer liquid to ice efficiently, so that on average, the clouds were fully glaciated at T approximately 260K, irrespective of the ice nucleation parameterization used. Comparison of simulated ice water path to available satellite derived observations were also performed, finding that all the schemes tested with the BN parameterization predicted 20 average values of IWP within plus or minus 15% of the observations.

  7. An orthosteric inhibitor of the RAS-SOS interaction.

    Science.gov (United States)

    Nickerson, Seth; Joy, Stephen T; Arora, Paramjit S; Bar-Sagi, Dafna

    2013-01-01

    Rat sarcoma (RAS) proteins are signaling nodes that transduce extracellular cues into precise alterations in cellular physiology by engaging effector pathways. RAS signaling thus regulates diverse cell processes including proliferation, migration, differentiation, and survival. Owing to this central role in governing mitogenic signals, RAS pathway components are often dysregulated in human diseases. Targeted therapy of RAS pathways has generally not been successful, largely because of the robust biochemistry of the targets and their multifaceted network of molecular regulators. The rate-limiting step of RAS activation is Son of Sevenless (SOS)-mediated nucleotide exchange involving a single evolutionarily conserved catalytic helix from SOS. Structure function data of this mechanism provided a strong platform to design an SOS-derived, helically constrained peptide mimic as an inhibitor of the RAS-SOS interaction. In this chapter, we review RAS-SOS signaling dynamics and present evidence supporting the novel paradigm of inhibiting their interaction as a therapeutic strategy. We then describe a method of generating helically constrained peptide mimics of protein surfaces, which we have employed to inhibit the RAS-SOS active site interaction. The biochemical and functional properties of this SOS mimic support the premise that inhibition of RAS-nucleotide exchange can effectively block RAS activation and downstream signaling. © 2013 Elsevier Inc. All rights reserved.

  8. In service design by simulations

    Energy Technology Data Exchange (ETDEWEB)

    Nasr H. Ghoniem

    2004-03-14

    Irradiation of materials by energetic particles (e.g. electrons, ions and neutrons) is associated with very high internal power dissipation, which can drive the underlying nano- and microstructure far from normal equilibrium conditions. One of the most unusual responses in this connection is the ability of the material's nano- and microstructure to self-assemble in well-organized, two- and three-dimensional periodic arrangements. We reviewed and assessed experimental evidence and theoretical models pertaining to the physical understanding of nano- and microstructure self-organization under irradiation conditions. Experimental observations on the formation of self-organized defect clusters, dislocation loops, voids and bubbles were presented and critically assessed. Implantation of metals with energetic helium results in remarkable self-assembled bubble super-lattices with wavelengths (super-lattice parameters) in the range of 5-8 nm. Ion and neutron irradiation produce a wide variety of self-assembled 3-D defect walls and void lattices, with wavelengths that can be tailored in the range of 10's to 100's of nanometers. Theoretical models aimed at explaining these observations were introduced, and a consistent description of many features is outlined. The primary focus of the most recent modeling efforts, which are based on stability theory and concepts of non-linear dynamics, was to determine criteria for the evolution and spatial symmetry of self-organized microstructures. The correspondence between this theoretical framework and experimental observations was also examined, highlighting areas of agreement and pointing out unresolved questions. The main objective of this research was to develop new computational tools for in-service design and performance prediction of advanced fusion material systems by computational simulation. We also need to develop these computational tools to assist in planning and assessment of corresponding radiation

  9. What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf.

    Science.gov (United States)

    Filchtinski, Daniel; Sharabi, Oz; Rüppel, Alma; Vetter, Ingrid R; Herrmann, Christian; Shifman, Julia M

    2010-06-11

    Ras is a small GTP-binding protein that is an essential molecular switch for a wide variety of signaling pathways including the control of cell proliferation, cell cycle progression and apoptosis. In the GTP-bound state, Ras can interact with its effectors, triggering various signaling cascades in the cell. In the GDP-bound state, Ras looses its ability to bind to known effectors. The interaction of the GTP-bound Ras (Ras(GTP)) with its effectors has been studied intensively. However, very little is known about the much weaker interaction between the GDP-bound Ras (Ras(GDP)) and Ras effectors. We investigated the factors underlying the nucleotide-dependent differences in Ras interactions with one of its effectors, Raf kinase. Using computational protein design, we generated mutants of the Ras-binding domain of Raf kinase (Raf) that stabilize the complex with Ras(GDP). Most of our designed mutations narrow the gap between the affinity of Raf for Ras(GTP) and Ras(GDP), producing the desired shift in binding specificity towards Ras(GDP). A combination of our best designed mutation, N71R, with another mutation, A85K, yielded a Raf mutant with a 100-fold improvement in affinity towards Ras(GDP). The Raf A85K and Raf N71R/A85K mutants were used to obtain the first high-resolution structures of Ras(GDP) bound to its effector. Surprisingly, these structures reveal that the loop on Ras previously termed the switch I region in the Ras(GDP).Raf mutant complex is found in a conformation similar to that of Ras(GTP) and not Ras(GDP). Moreover, the structures indicate an increased mobility of the switch I region. This greater flexibility compared to the same loop in Ras(GTP) is likely to explain the natural low affinity of Raf and other Ras effectors to Ras(GDP). Our findings demonstrate that an accurate balance between a rigid, high-affinity conformation and conformational flexibility is required to create an efficient and stringent molecular switch. Copyright 2010 Elsevier Ltd

  10. RAS - Screens & Assays - Drug Discovery

    Science.gov (United States)

    The RAS Drug Discovery group aims to develop assays that will reveal aspects of RAS biology upon which cancer cells depend. Successful assay formats are made available for high-throughput screening programs to yield potentially effective drug compounds.

  11. Simulation and Spacecraft Design: Engineering Mars Landings.

    Science.gov (United States)

    Conway, Erik M

    2015-10-01

    A key issue in history of technology that has received little attention is the use of simulation in engineering design. This article explores the use of both mechanical and numerical simulation in the design of the Mars atmospheric entry phases of the Viking and Mars Pathfinder missions to argue that engineers used both kinds of simulation to develop knowledge of their designs' likely behavior in the poorly known environment of Mars. Each kind of simulation could be used as a warrant of the other's fidelity, in an iterative process of knowledge construction.

  12. Ras activation by SOS

    DEFF Research Database (Denmark)

    Iversen, Lars; Tu, Hsiung-Lin; Lin, Wan-Chen

    2014-01-01

    Activation of the small guanosine triphosphatase H-Ras by the exchange factor Son of Sevenless (SOS) is an important hub for signal transduction. Multiple layers of regulation, through protein and membrane interactions, govern activity of SOS. We characterized the specific activity of individual ...

  13. CMOS circuit design, layout and simulation

    CERN Document Server

    Baker, R Jacob

    2010-01-01

    The Third Edition of CMOS Circuit Design, Layout, and Simulation continues to cover the practical design of both analog and digital integrated circuits, offering a vital, contemporary view of a wide range of analog/digital circuit blocks including: phase-locked-loops, delta-sigma sensing circuits, voltage/current references, op-amps, the design of data converters, and much more. Regardless of one's integrated circuit (IC) design skill level, this book allows readers to experience both the theory behind, and the hands-on implementation of, complementary metal oxide semiconductor (CMOS) IC design via detailed derivations, discussions, and hundreds of design, layout, and simulation examples.

  14. Simulation of integrated beam experiment designs

    International Nuclear Information System (INIS)

    Grote, D.P.; Sharp, W.M.

    2004-01-01

    Simulation of designs of an Integrated Beam Experiment (IBX) class accelerator have been carried out. These simulations are an important tool for validating such designs. Issues such as envelope mismatch and emittance growth can be examined in a self-consistent manner, including the details of injection, accelerator transitions, long-term transport, and longitudinal compression. The simulations are three-dimensional and time-dependent, and begin at the source. They continue up through the end of the acceleration region, at which point the data is passed on to a separate simulation of the drift compression. Results are be presented

  15. Crash simulations for interior design

    NARCIS (Netherlands)

    Poeze, E.; Slaats, P.M.A.

    1996-01-01

    With the increasing number of compact cars, safety aspects becomes increasingly important for interior designs. The smaller dimensions of these cars do not only decrease the car mass, but also the energy absorption length, resulting in a more severe crash pulse. As a consequence, the inertia loading

  16. Energy simulation in building design

    NARCIS (Netherlands)

    Hensen, J.L.M.

    1992-01-01

    Design decision support related to building energy consumption and / or indoor climate, should be based on an integral approach of environment, building, heating, ventilating and airconditioning (HVAC) system and occupants. The tools to achieve this are now available in the form of computer

  17. Simulation Integrated Design for Logistics

    NARCIS (Netherlands)

    Veeke, H.P.M.

    2003-01-01

    The design of an innovative logistic system is a complex problem in the solution of which many disciplines are involved. Each discipline developed its own way of conceptual modeling for a logistic system based on a mono disciplinary perception. In essence this leads to a communication problem

  18. Analysis of the diffusion of Ras2 in Saccharomyces cerevisiae using fluorescence recovery after photobleaching

    International Nuclear Information System (INIS)

    Vinnakota, Kalyan C; Wakatsuki, Tetsuro; Beard, Daniel A; Mitchell, David A; Deschenes, Robert J

    2010-01-01

    Binding, lateral diffusion and exchange are fundamental dynamic processes involved in protein association with cellular membranes. In this study, we developed numerical simulations of lateral diffusion and exchange of fluorophores in membranes with arbitrary bleach geometry and exchange of the membrane-localized fluorophore with the cytosol during fluorescence recovery after photobleaching (FRAP) experiments. The model simulations were used to design FRAP experiments with varying bleach region sizes on plasma membrane-localized wild-type GFP-Ras2 with a dual lipid anchor and mutant GFP-Ras2C318S with a single lipid anchor in live yeast cells to investigate diffusional mobility and the presence of any exchange processes operating in the time scale of our experiments. Model parameters estimated using data from FRAP experiments with a 1 µm × 1 µm bleach region-of-interest (ROI) and a 0.5 µm × 0.5 µm bleach ROI showed that GFP-Ras2, single or dual lipid modified, diffuses as single species with no evidence of exchange with a cytoplasmic pool. This is the first report of Ras2 mobility in the yeast plasma membrane. The methods developed in this study are generally applicable for studying diffusion and exchange of membrane-associated fluorophores using FRAP on commercial confocal laser scanning microscopes

  19. Design and Analysis of simulation experiments : Tutorial

    NARCIS (Netherlands)

    Kleijnen, J.P.C.

    2017-01-01

    This tutorial reviews the design and analysis of simulation experiments. These experiments may have various goals: validation, prediction, sensitivity analysis, optimization (possibly robust), and risk or uncertainty analysis. These goals may be realized through metamodels. Two types of metamodels

  20. Simulation for (sustainable) building design: Czech experiences

    NARCIS (Netherlands)

    Bartak, M.; Drkal, F.; Hensen, J.L.M.; Lain, M.; Schwarzer, J.; Sourek, B.

    2001-01-01

    This paper attempts to outline the current state-of-the-art in the Czech Republic regarding the use of integrated building performance simulation as a design tool. Integrated performance simulation for reducing the environmental impact of buildings is illustrated by means of three recent HVAC

  1. Slab cooling system design using computer simulation

    NARCIS (Netherlands)

    Lain, M.; Zmrhal, V.; Drkal, F.; Hensen, J.L.M.

    2007-01-01

    For a new technical library building in Prague computer simulations were carried out to help design of slab cooling system and optimize capacity of chillers. In the paper is presented concept of new technical library HVAC system, the model of the building, results of the energy simulations for

  2. Modeling and simulation for RF system design

    CERN Document Server

    Frevert, Ronny; Jancke, Roland; Knöchel, Uwe; Schwarz, Peter; Kakerow, Ralf; Darianian, Mohsen

    2005-01-01

    Focusing on RF specific modeling and simulation methods, and system and circuit level descriptions, this work contains application-oriented training material. Accompanied by a CD- ROM, it combines the presentation of a mixed-signal design flow, an introduction into VHDL-AMS and Verilog-A, and the application of commercially available simulators.

  3. Novel Methods for Electromagnetic Simulation and Design

    Science.gov (United States)

    2016-08-03

    modeling software that can handle complicated, electrically large objects in a manner that is sufficiently fast to allow design by simulation. 15. SUBJECT...electrically large objects in a manner that is sufficiently fast to allow design by simulation. We also developed new methods for scattering from cavities in a...basis for high fidelity modeling software that can handle complicated, electrically large objects in a manner that is sufficiently fast to allow

  4. Proactive building simulations for early design support

    DEFF Research Database (Denmark)

    Østergård, Torben

    important design parameters that require the most attention when seeking to improve building performance. Fast metamodels facilitate immediate feedback on design changes and reduce time-consumption related to performance assessment. Ultimately, the work described in this thesis and on buildingdesign...... that relies on thousands of simulations representing the multidimensional design space. Interactive visualizations enable decision-makers to explore, in real-time, the vast design space and identify favorable solutions which satisfy the needs of different stakeholders. Sensitivity analysis helps reveal...

  5. Simulation tools for detector and instrument design

    DEFF Research Database (Denmark)

    Kanaki, Kalliopi; Kittelmann, Thomas; Cai, Xiao Xiao

    2018-01-01

    The high performance requirements at the European Spallation Source have been driving the technological advances on the neutron detector front. Now more than ever is it important to optimize the design of detectors and instruments, to fully exploit the ESS source brilliance. Most of the simulation...... a powerful set of tools to tailor the detector and instrument design to the instrument application....

  6. On architectural acoustic design using computer simulation

    DEFF Research Database (Denmark)

    Schmidt, Anne Marie Due; Kirkegaard, Poul Henning

    2004-01-01

    properties prior to the actual construction of a building. With the right tools applied, acoustic design can become an integral part of the architectural design process. The aim of this paper is to investigate the field of application that an acoustic simulation programme can have during an architectural...... acoustic design process. The emphasis is put on the first three out of five phases in the working process of the architect and a case study is carried out in which each phase is represented by typical results ? as exemplified with reference to the design of Bagsværd Church by Jørn Utzon. The paper...... discusses the advantages and disadvantages of the programme in each phase compared to the works of architects not using acoustic simulation programmes. The conclusion of the paper is that the application of acoustic simulation programs is most beneficial in the last of three phases but an application...

  7. Participatory simulation in hospital work system design

    DEFF Research Database (Denmark)

    Andersen, Simone Nyholm

    When ergonomic considerations are integrated into the design of work systems, both overall system performance and employee well-being improve. A central part of integrating ergonomics in work system design is to benefit from emplo y-ees’ knowledge of existing work systems. Participatory simulation...... (PS) is a method to access employee knowledge; namely employees are involved in the simulation and design of their own future work systems through the exploration of models representing work system designs. However, only a few studies have investigated PS and the elements of the method. Yet...... understanding the elements is essential when analyzing and planning PS in research and practice. This PhD study investigates PS and the method elements in the context of the Danish hospital sector, where PS is applied in the renewal and design of public hospitals and the work systems within the hospitals...

  8. On Architectural Acoustics Design using Computer Simulation

    DEFF Research Database (Denmark)

    Schmidt, Anne Marie Due; Kirkegaard, Poul Henning

    2004-01-01

    The acoustical quality of a given building, or space within the building, is highly dependent on the architectural design. Architectural acoustics design has in the past been based on simple design rules. However, with a growing complexity in the architectural acoustic and the emergence of potent...... room acoustic simulation programs it is now possible to subjectively analyze and evaluate acoustic properties prior to the actual construction of a facility. With the right tools applied, the acoustic design can become an integrated part of the architectural design process. The aim of the present paper...... this information is discussed. The conclusion of the paper is that the application of acoustical simulation programs is most beneficial in the last of three phases but that an application of the program to the two first phases would be preferable and possible with an improvement of the interface of the program....

  9. NUMERICAL MODEL APPLICATION IN ROWING SIMULATOR DESIGN

    Directory of Open Access Journals (Sweden)

    Petr Chmátal

    2016-04-01

    Full Text Available The aim of the research was to carry out a hydraulic design of rowing/sculling and paddling simulator. Nowadays there are two main approaches in the simulator design. The first one includes a static water with no artificial movement and counts on specially cut oars to provide the same resistance in the water. The second approach, on the other hand uses pumps or similar devices to force the water to circulate but both of the designs share many problems. Such problems are affecting already built facilities and can be summarized as unrealistic feeling, unwanted turbulent flow and bad velocity profile. Therefore, the goal was to design a new rowing simulator that would provide nature-like conditions for the racers and provide an unmatched experience. In order to accomplish this challenge, it was decided to use in-depth numerical modeling to solve the hydraulic problems. The general measures for the design were taken in accordance with space availability of the simulator ́s housing. The entire research was coordinated with other stages of the construction using BIM. The detailed geometry was designed using a numerical model in Ansys Fluent and parametric auto-optimization tools which led to minimum negative hydraulic phenomena and decreased investment and operational costs due to the decreased hydraulic losses in the system.

  10. H-RAS, K-RAS, and N-RAS gene activation in human bladder cancers.

    Science.gov (United States)

    Przybojewska, B; Jagiello, A; Jalmuzna, P

    2000-08-01

    Bladder cancer is one of the leading causes of cancer death in most developed countries. In this work, 19 bladder cancer specimens, along with their infiltrations of the urinary bladder wall from the same patients, were examined for the presence of H-RAS, K-RAS, and N-RAS activation using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The H-RAS activation was found in 15 (about 84%) of the 19 bladder cancers studied. The same results were obtained in the infiltrating urinary bladder wall samples. N-RAS gene mutations were observed in all cases (except 1) in which H-RAS gene mutations were detected. The results suggest a strong relationship between H-RAS and N-RAS gene activation in bladder cancer. Changes in the K-RAS gene in bladder cancers seem to be a rare event; this is in agreement with findings of other authors. We found activation of the gene in one specimen of bladder cancer and its infiltration of the urinary bladder wall in the same patient.

  11. Design of penicillin fermentation process simulation system

    Science.gov (United States)

    Qi, Xiaoyu; Yuan, Zhonghu; Qi, Xiaoxuan; Zhang, Wenqi

    2011-10-01

    Real-time monitoring for batch process attracts increasing attention. It can ensure safety and provide products with consistent quality. The design of simulation system of batch process fault diagnosis is of great significance. In this paper, penicillin fermentation, a typical non-linear, dynamic, multi-stage batch production process, is taken as the research object. A visual human-machine interactive simulation software system based on Windows operation system is developed. The simulation system can provide an effective platform for the research of batch process fault diagnosis.

  12. Detector simulation needs for detector designers

    International Nuclear Information System (INIS)

    Hanson, G.G.

    1987-11-01

    Computer simulation of the components of SSC detectors and of the complete detectors will be very important for the designs of the detectors. The ratio of events from interesting physics to events from background processes is very low, so detailed understanding of detector response to the backgrounds is needed. Any large detector for the SSC will be very complex and expensive and every effort must be made to design detectors which will have excellent performance and will not have to undergo major rebuilding. Some areas in which computer simulation is particularly needed are pattern recognition in tracking detectors and development of shower simulation code which can be trusted as an aid in the design and optimization of calorimeters, including their electron identification performance. Existing codes require too much computer time to be practical and need to be compared with test beam data at energies of several hundred GeV. Computer simulation of the processing of the data, including electronics response to the signals from the detector components, processing of the data by microprocessors on the detector, the trigger, and data acquisition will be required. In this report we discuss the detector simulation needs for detector designers

  13. Thin-film designs by simulated annealing

    Science.gov (United States)

    Boudet, T.; Chaton, P.; Herault, L.; Gonon, G.; Jouanet, L.; Keller, P.

    1996-11-01

    With the increasing power of computers, new methods in synthesis of optical multilayer systems have appeared. Among these, the simulated-annealing algorithm has proved its efficiency in several fields of physics. We propose to show its performances in the field of optical multilayer systems through different filter designs.

  14. Electromechanical motion systems design and simulation

    CERN Document Server

    Moritz, Frederick G

    2013-01-01

    An introductory reference covering the devices, simulations and limitations in the control of servo systems Linking theoretical material with real-world applications, this book provides a valuable introduction to motion system design. The book begins with an overview of classic theory, its advantages and limitations, before showing how classic limitations can be overcome with complete system simulation. The ability to efficiently vary system parameters (such as inertia, friction, dead-band, damping), and quickly determine their effect on performance, stability, efficiency, is also described. T

  15. CAGE IIIA Distributed Simulation Design Methodology

    Science.gov (United States)

    2014-05-01

    2 VHF Very High Frequency VLC Video LAN Codec – an Open-source cross-platform multimedia player and framework VM Virtual Machine VOIP Voice Over...Implementing Defence Experimentation (GUIDEx). The key challenges for this methodology are with understanding how to: • design it o define the...operation and to be available in the other nation’s simulations. The challenge for the CAGE campaign of experiments is to continue to build upon this

  16. Mevalonates, Ras and Breast Cancer

    National Research Council Canada - National Science Library

    White, Michael

    2001-01-01

    .... This selective inhibition appears to be a consequence of expression of oncogenic Ras. Here we are evaluating the ability of Fmev to selectively interfere with proliferation of breast cancer cells...

  17. Design and characterization of a cough simulator.

    Science.gov (United States)

    Zhang, Bo; Zhu, Chao; Ji, Zhiming; Lin, Chao-Hsin

    2017-02-23

    Expiratory droplets from human coughing have always been considered as potential carriers of pathogens, responsible for respiratory infectious disease transmission. To study the transmission of disease by human coughing, a transient repeatable cough simulator has been designed and built. Cough droplets are generated by different mechanisms, such as the breaking of mucus, condensation and high-speed atomization from different depths of the respiratory tract. These mechanisms in coughing produce droplets of different sizes, represented by a bimodal distribution of 'fine' and 'coarse' droplets. A cough simulator is hence designed to generate transient sprays with such bimodal characteristics. It consists of a pressurized gas tank, a nebulizer and an ejector, connected in series, which are controlled by computerized solenoid valves. The bimodal droplet size distribution is characterized for the coarse droplets and fine droplets, by fibrous collection and laser diffraction, respectively. The measured size distributions of coarse and fine droplets are reasonably represented by the Rosin-Rammler and log-normal distributions in probability density function, which leads to a bimodal distribution. To assess the hydrodynamic consequences of coughing including droplet vaporization and polydispersion, a Lagrangian model of droplet trajectories is established, with its ambient flow field predetermined from a computational fluid dynamics simulation.

  18. Drug design: Insights from atomistic simulations

    International Nuclear Information System (INIS)

    Collu, F.; Spiga, E.; Kumar, A.; Hajjar, E.; Vargiu, A.V.; Ceccarelli, M.; Ruggerone, P.

    2009-01-01

    Computer simulations have become a widely used and powerful tool to study the behaviour of many-particle and many-interaction systems and processes such as nucleic acid dynamics, drug-DNA interactions, enzymatic processes, membrane, antibiotics. The increased reliability of computational techniques has made possible to plane a bottom-up approach in drug design, i.e. designing molecules with improved properties starting from the knowledge of the molecular mechanisms. However, the in silico techniques have to face the fact that the number of degrees of freedom involved in biological systems is very large while the time scale of several biological processes is not accessible to standard simulations. Algorithms and methods have been developed and are still under construction to bridge these gaps. Here we review the activities of our group focussed on the time-scale bottleneck and, in particular, on the use of the meta dynamics scheme that allows the investigation of rare events in reasonable computer time without reducing the accuracy of the calculation. In particular, we have devoted particular attention to the characterization at microscopic level of translocation of antibiotics through membrane pores, aiming at the identification of structural and dynamical features helpful for a rational drug design.

  19. Simulation-based disassembly systems design

    Science.gov (United States)

    Ohlendorf, Martin; Herrmann, Christoph; Hesselbach, Juergen

    2004-02-01

    Recycling of Waste of Electrical and Electronic Equipment (WEEE) is a matter of actual concern, driven by economic, ecological and legislative reasons. Here, disassembly as the first step of the treatment process plays a key role. To achieve sustainable progress in WEEE disassembly, the key is not to limit analysis and planning to merely disassembly processes in a narrow sense, but to consider entire disassembly plants including additional aspects such as internal logistics, storage, sorting etc. as well. In this regard, the paper presents ways of designing, dimensioning, structuring and modeling different disassembly systems. Goal is to achieve efficient and economic disassembly systems that allow recycling processes complying with legal requirements. Moreover, advantages of applying simulation software tools that are widespread and successfully utilized in conventional industry sectors are addressed. They support systematic disassembly planning by means of simulation experiments including consecutive efficiency evaluation. Consequently, anticipatory recycling planning considering various scenarios is enabled and decisions about which types of disassembly systems evidence appropriateness for specific circumstances such as product spectrum, throughput, disassembly depth etc. is supported. Furthermore, integration of simulation based disassembly planning in a holistic concept with configuration of interfaces and data utilization including cost aspects is described.

  20. Regulation of p21ras activity

    DEFF Research Database (Denmark)

    Lowy, D R; Zhang, K; DeClue, J E

    1992-01-01

    The ras genes encode GTP/GDP-binding proteins that participate in mediating mitogenic signals from membrane tyrosine kinases to downstream targets. The activity of p21ras is determined by the concentration of GTP-p21ras, which is tightly regulated by a complex array of positive and negative control...... mechanisms. GAP and NF1 can negatively regulate p21ras activity by stimulating hydrolysis of GTP bound to p21ras. Other cellular factors can positively regulate p21ras by stimulating GDP/GTP exchange....

  1. Software for natural gas pipeline design and simulation (gaspisim ...

    African Journals Online (AJOL)

    Software for natural gas pipeline design and simulation (gaspisim) ... This paper focuses on the development of software for optimum design and simulation of natural gas pipeline. General ... EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT

  2. Ras proteins have multiple functions in vegetative cells of Dictyostelium.

    Science.gov (United States)

    Bolourani, Parvin; Spiegelman, George; Weeks, Gerald

    2010-11-01

    During the aggregation of Dictyostelium cells, signaling through RasG is more important in regulating cyclic AMP (cAMP) chemotaxis, whereas signaling through RasC is more important in regulating the cAMP relay. However, RasC is capable of substituting for RasG for chemotaxis, since rasG⁻ cells are only partially deficient in chemotaxis, whereas rasC⁻/rasG⁻ cells are totally incapable of chemotaxis. In this study we have examined the possible functional overlap between RasG and RasC in vegetative cells by comparing the vegetative cell properties of rasG⁻, rasC⁻, and rasC⁻/rasG⁻ cells. In addition, since RasD, a protein not normally found in vegetative cells, is expressed in vegetative rasG⁻ and rasC⁻/rasG⁻ cells and appears to partially compensate for the absence of RasG, we have also examined the possible functional overlap between RasG and RasD by comparing the properties of rasG⁻ and rasC⁻/rasG⁻ cells with those of the mutant cells expressing higher levels of RasD. The results of these two lines of investigation show that RasD is capable of totally substituting for RasG for cytokinesis and growth in suspension, whereas RasC is without effect. In contrast, for chemotaxis to folate, RasC is capable of partially substituting for RasG, but RasD is totally without effect. Finally, neither RasC nor RasD is able to substitute for the role that RasG plays in regulating actin distribution and random motility. These specificity studies therefore delineate three distinct and none-overlapping functions for RasG in vegetative cells.

  3. Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region.

    Science.gov (United States)

    Jang, Hyunbum; Abraham, Sherwin J; Chavan, Tanmay S; Hitchinson, Ben; Khavrutskii, Lyuba; Tarasova, Nadya I; Nussinov, Ruth; Gaponenko, Vadim

    2015-04-10

    K-Ras4B belongs to a family of small GTPases that regulates cell growth, differentiation and survival. K-ras is frequently mutated in cancer. K-Ras4B association with the plasma membrane through its farnesylated and positively charged C-terminal hypervariable region (HVR) is critical to its oncogenic function. However, the structural mechanisms of membrane association are not fully understood. Here, using confocal microscopy, surface plasmon resonance, and molecular dynamics simulations, we observed that K-Ras4B can be distributed in rigid and loosely packed membrane domains. Its membrane binding domain interaction with phospholipids is driven by membrane fluidity. The farnesyl group spontaneously inserts into the disordered lipid microdomains, whereas the rigid microdomains restrict the farnesyl group penetration. We speculate that the resulting farnesyl protrusion toward the cell interior allows oligomerization of the K-Ras4B membrane binding domain in rigid microdomains. Unlike other Ras isoforms, K-Ras4B HVR contains a single farnesyl modification and positively charged polylysine sequence. The high positive charge not only modulates specific HVR binding to anionic phospholipids but farnesyl membrane orientation. Phosphorylation of Ser-181 prohibits spontaneous farnesyl membrane insertion. The mechanism illuminates the roles of HVR modifications in K-Ras4B targeting microdomains of the plasma membrane and suggests an additional function for HVR in regulation of Ras signaling. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  4. Mechanisms of Membrane Binding of Small GTPase K-Ras4B Farnesylated Hypervariable Region*

    Science.gov (United States)

    Jang, Hyunbum; Abraham, Sherwin J.; Chavan, Tanmay S.; Hitchinson, Ben; Khavrutskii, Lyuba; Tarasova, Nadya I.; Nussinov, Ruth; Gaponenko, Vadim

    2015-01-01

    K-Ras4B belongs to a family of small GTPases that regulates cell growth, differentiation and survival. K-ras is frequently mutated in cancer. K-Ras4B association with the plasma membrane through its farnesylated and positively charged C-terminal hypervariable region (HVR) is critical to its oncogenic function. However, the structural mechanisms of membrane association are not fully understood. Here, using confocal microscopy, surface plasmon resonance, and molecular dynamics simulations, we observed that K-Ras4B can be distributed in rigid and loosely packed membrane domains. Its membrane binding domain interaction with phospholipids is driven by membrane fluidity. The farnesyl group spontaneously inserts into the disordered lipid microdomains, whereas the rigid microdomains restrict the farnesyl group penetration. We speculate that the resulting farnesyl protrusion toward the cell interior allows oligomerization of the K-Ras4B membrane binding domain in rigid microdomains. Unlike other Ras isoforms, K-Ras4B HVR contains a single farnesyl modification and positively charged polylysine sequence. The high positive charge not only modulates specific HVR binding to anionic phospholipids but farnesyl membrane orientation. Phosphorylation of Ser-181 prohibits spontaneous farnesyl membrane insertion. The mechanism illuminates the roles of HVR modifications in K-Ras4B targeting microdomains of the plasma membrane and suggests an additional function for HVR in regulation of Ras signaling. PMID:25713064

  5. Designing solar thermal experiments based on simulation

    International Nuclear Information System (INIS)

    Huleihil, Mahmoud; Mazor, Gedalya

    2013-01-01

    In this study three different models to describe the temperature distribution inside a cylindrical solid body subjected to high solar irradiation were examined, beginning with the simpler approach, which is the single dimension lump system (time), progressing through the two-dimensional distributed system approach (time and vertical direction), and ending with the three-dimensional distributed system approach with azimuthally symmetry (time, vertical direction, and radial direction). The three models were introduced and solved analytically and numerically. The importance of the models and their solution was addressed. The simulations based on them might be considered as a powerful tool in designing experiments, as they make it possible to estimate the different effects of the parameters involved in these models

  6. Design and Simulation of Nano Wire FET

    Directory of Open Access Journals (Sweden)

    M. Anil Kumar

    2017-06-01

    Full Text Available As the era of classical planar metal-oxide-semiconductor field-effect transistors (MOSFETs comes to an end, the semiconductor industry is beginning to adopt 3D device architectures, such as FinFETs, starting at the 22 nm technology node. Since physical limits such as short channel effect (SCE and self-heating may dominate, it may be difficult to scale Si FinFET below 10 nm. In this regard, transistors with different materials, geometries, or operating principles may help. For example, gate has excellent electrostatic control over 2D thin film channel with planar geometry and 1D nanowire (NW channel with gate-all-around (GAA geometry to reduce SCE. High carrier mobility of single wall carbon nanotube (SWNT or III-V channels may reduce VDD to reduce power consumption. Therefore, as channel of transistor, 2D thin film of array SWNTs and 1D III-V multi NWs are promising for sub 10 nm technology nodes. To simulate these devices, accurate modelling and design based on gate-material are necessary to assess their performance limits, since cross-sections of the multi-gate NWFETs are expected to be a few nano-meters wide in their ultimate scaling. In this paper we have explored the use of SILVACO with different materials for simulating and studying the short channel behaviour of nanowire FETs.

  7. Mutational analysis of a ras catalytic domain

    DEFF Research Database (Denmark)

    Willumsen, B M; Papageorge, A G; Kung, H F

    1986-01-01

    localization. We speculate that this latter region interacts with the putative cellular target of ras. The results suggest that transforming ras proteins require membrane localization, guanosine nucleotide binding, and an additional undefined function that may represent interaction with their target....

  8. Hygrothermal Simulation: A Tool for Building Envelope Design Analysis

    Science.gov (United States)

    Samuel V. Glass; Anton TenWolde; Samuel L. Zelinka

    2013-01-01

    Is it possible to gauge the risk of moisture problems while designing the building envelope? This article provides a brief introduction to computer-based hygrothermal (heat and moisture) simulation, shows how simulation can be useful as a design tool, and points out a number of im-portant considerations regarding model inputs and limita-tions. Hygrothermal simulation...

  9. Ras signaling in aging and metabolic regulation.

    Science.gov (United States)

    Slack, Cathy

    2017-12-07

    Aberrant signal transduction downstream of the Ras GTPase has a well-established role in tumorigenesis. Mutations that result in hyperactivation of Ras are responsible for a third of all human cancers. Hence, small molecule inhibitors of the Ras signal transduction cascade have been under intense focus as potential cancer treatments. In both invertebrate and mammalian models, emerging evidence has also implicated components of the Ras signaling pathway in aging and metabolic regulation. Here, I review the current evidence for Ras signaling in these newly discovered roles highlighting the interactions between the Ras pathway and other longevity assurance mechanisms. Defining the role of Ras signaling in maintaining age-related health may have important implications for the development of interventions that could not only increase lifespan but also delay the onset and/or progression of age-related functional decline.

  10. Design of a bounded wave EMP (Electromagnetic Pulse) simulator

    Science.gov (United States)

    Sevat, P. A. A.

    1989-06-01

    Electromagnetic Pulse (EMP) simulators are used to simulate the EMP generated by a nuclear weapon and to harden equipment against the effects of EMP. At present, DREO has a 1 m EMP simulator for testing computer terminal size equipment. To develop the R and D capability for testing larger objects, such as a helicopter, a much bigger threat level facility is required. This report concerns the design of a bounded wave EMP simulator suitable for testing large size equipment. Different types of simulators are described and their pros and cons are discussed. A bounded wave parallel plate type simulator is chosen for it's efficiency and the least environmental impact. Detailed designs are given for 6 m and 10 m parallel plate type wire grid simulators. Electromagnetic fields inside and outside the simulators are computed. Preliminary specifications for a pulse generator required for the simulator are also given. Finally, the electromagnetic fields radiated from the simulator are computed and discussed.

  11. Simulation-Based System Design Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — The research objective is to develop, test, and implement effective and efficient simulation techniques for modeling, evaluating, and optimizing systems in order to...

  12. Simulation of sparse matrix array designs

    Science.gov (United States)

    Boehm, Rainer; Heckel, Thomas

    2018-04-01

    Matrix phased array probes are becoming more prominently used in industrial applications. The main drawbacks, using probes incorporating a very large number of transducer elements, are needed for an appropriate cabling and an ultrasonic device offering many parallel channels. Matrix arrays designed for extended functionality feature at least 64 or more elements. Typical arrangements are square matrices, e.g., 8 by 8 or 11 by 11 or rectangular matrixes, e.g., 8 by 16 or 10 by 12 to fit a 128-channel phased array system. In some phased array systems, the number of simultaneous active elements is limited to a certain number, e.g., 32 or 64. Those setups do not allow running the probe with all elements active, which may cause a significant change in the directivity pattern of the resulting sound beam. When only a subset of elements can be used during a single acquisition, different strategies may be applied to collect enough data for rebuilding the missing information from the echo signal. Omission of certain elements may be one approach, overlay of subsequent shots with different active areas may be another one. This paper presents the influence of a decreased number of active elements on the sound field and their distribution on the array. Solutions using subsets with different element activity patterns on matrix arrays and their advantages and disadvantages concerning the sound field are evaluated using semi-analytical simulation tools. Sound field criteria are discussed, which are significant for non-destructive testing results and for the system setup.

  13. K-RAS and N-RAS mutations in testicular germ cell tumors

    Directory of Open Access Journals (Sweden)

    Bekir Muhammet Hacioglu

    2017-05-01

    Full Text Available Testicular cancer is a relatively rare tumor type, accounting for approximately 1% of all cancers in men. However, among men aged between 15 and 40 years, testicular cancer is the most commonly diagnosed malignancy. Testicular germ cell tumors (TGCTs are classified as seminoma and non-seminoma. The RAS oncogene controls several cellular functions, including cell proliferation, apoptosis, migration, and differentiation. Thus, RAS signaling is important for normal germ cell development. Mutations of the Kirsten RAS (K-RAS gene are present in over 20% of all cancers. RAS gene mutations have also been reported in TGCTs. We investigated K-RAS and N-RAS mutations in seminoma and non-seminoma TGCT patients. A total of 24 (55% pure seminoma cases and 19 (45% non-seminoma cases were included in the study. K-RAS and N-RAS analyses were performed in our molecular pathology laboratory, using K-RAS and N-RAS Pyro Kit 24 V1 (Qiagen. In total, a RAS mutation was present in 12 patients (27%: 7 seminoma (29% and 5 non-seminoma cases (26% [p = 0.55]. A K-RAS mutation was present in 4 pure seminoma tumors (16% and 3 non-seminoma tumors (15% [p = 0.63], and an N-RAS mutation was observed in 4 seminoma tumors (16% and 3 non-seminoma tumors (15% [p = 0.63]. Both, K-RAS and N-RAS mutations were present in two patients: one with seminoma tumor and the other with non-seminoma tumor. To date, no approved targeted therapy is available for the treatment of TGCTs. The analysis of K-RAS and N-RAS mutations in these tumors may provide more treatment options, especially in platinum-resistant tumors.

  14. HF filter design and computer simulation

    CERN Document Server

    Rhea, Randall W

    1994-01-01

    A book for engineers who design and build filters of all types, including lumped element, coaxial, helical, dielectric resonator, stripline and microstrip types. A thorough review of classic and modern filter design techniques, containing extensive practical design information of passband characteristics, topologies and transformations, component effects and matching. An excellent text for the design and construction of microstrip filters.

  15. Design of blast simulators for nuclear testing

    International Nuclear Information System (INIS)

    Mark, A.; Opalka, K.O.; Kitchens, C.W. Jr.

    1983-01-01

    A quasi-one-dimensional computational technique is used to model the flow of a large, complicated shock tube. The shock tube, or Large Blast Simulator, is used to simulate conventional or nuclear explosions by shaping the pressure history. Results from computations show favorable agreement when compared with data taken in the facility at Gramat, France. Such future shock tubes will include a thermal irradiation capability to better simulate a nuclear event. The computations point to the need for venting of the combustion products since the pressure history will be considerably altered as the shock propagates through these hot gases

  16. Application of discrete event simulation to MRS design

    International Nuclear Information System (INIS)

    Bali, M.; Standley, W.

    1993-01-01

    The application of discrete event simulation to the Monitored, Retrievable Storage (MRS) material handling operations supported the MRS conceptual design effort and established a set of tools for use during MRS detail design and license application. The effort to develop a design analysis tool to support the MRS project started in 1991. The MRS simulation has so far identified potential savings and suggested methods of improving operations to enhance throughput. Immediately, simulation aided the MRS conceptual design effort through the investigation of alternative cask handling operations and the sizing and sharing of expensive equipment. The simulation also helped analyze the operability of the current design of MRS under various waste acceptance scenarios. Throughout the simulation effort, the model development and experimentation resulted in early identification and resolution of several design and operational issues

  17. Design of compact nuclear power marine engineering simulator

    International Nuclear Information System (INIS)

    Gao Jinghui; Xing Hongchuan; Zhang Ronghua; Yang Yanhua; Xu Jijun

    2004-01-01

    The essentiality of compact nuclear power marine engineering simulator (NPMES) is discussed. The technology of nuclear power plant engineering simulator (NPPES) for NPMES development is introduced, and the function design, general design and model design are given in details. A compact NPMES based on the nuclear power marine of 'Mutsu' is developed. The design can help the development of NPMES, which will improve operation safety and management efficiency of marine. (authors)

  18. Resistorless Electronically Tunable Grounded Inductance Simulator Design

    OpenAIRE

    Herencsár, Norbert; Kartci, Aslihan

    2017-01-01

    A new realization of grounded lossless positive inductance simulator (PIS) using simple inverting voltage buffer and unity-gain current follower/inverter (CF±) is reported. Considering the input intrinsic resistance of CF± as useful active parameter, the proposed PIS can be considered as resistorless circuit and it only employs in total 16 Metal-Oxide-Semiconductor (MOS) transistors and a grounded capacitor. The resulting equivalent inductance value of the proposed simulator can be adjusted v...

  19. Simulant Basis for the Standard High Solids Vessel Design

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, Reid A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Fiskum, Sandra K. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Suffield, Sarah R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Daniel, Richard C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Gauglitz, Phillip A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Wells, Beric E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-09-01

    This document provides the requirements for a test simulant suitable for demonstrating the mixing requirements for the Single High Solids Vessel Design (SHSVD). This simulant has not been evaluated for other purposes such as gas retention and release or erosion. The objective of this work is to provide an underpinning for the simulant properties based on actual waste characterization.

  20. Design and construction of a basic principle simulator: an experiment

    International Nuclear Information System (INIS)

    Fernandez, O.; Galdoz, E.; Flury, C.; Fontanini, H.; Maciel, F.; Rovere, L.; Carpio, R.

    1992-01-01

    This paper describes activities developed over design and building of a Basic Principle Simulator for nuclear power plants. This simulator has been developed in Process Control Division of Bariloche Atomic Center, Argentina. This project was sponsored jointly by CNEA and Atomic Energy International Organization, through the United Nations Program for Development. The paper specially emphasizes aspects like: architecture design methodology of real time simulators; graphic environment and interfaces design for users and instructor interaction, and for display information; test and validation of the used models; and human resources formation. Finally describes the actual implementation of the simulator to be used in Embalse Nuclear Power Plant. (author)

  1. Using IMPRINT to Guide Experimental Design with Simulated Task Environments

    Science.gov (United States)

    2015-06-18

    USING IMPRINT TO GUIDE EXPERIMENTAL DESIGN OF SIMULATED TASK ENVIRONMENTS THESIS Gregory...ENG-MS-15-J-052 USING IMPRINT TO GUIDE EXPERIMENTAL DESIGN WITH SIMULATED TASK ENVIRONMENTS THESIS Presented to the Faculty Department...Civilian, USAF June 2015 DISTRIBUTION STATEMENT A. APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED. AFIT-ENG-MS-15-J-052 USING IMPRINT

  2. The role of simulation in designing for universal access

    DEFF Research Database (Denmark)

    Keates, Simeon; Looms, Peter

    2014-01-01

    the difficulty of finding and recruiting suitable participants. Simulation aids offer a potentially cost-effective replacement or complement to participatory design. This paper examines a number of the issues associated with the use of simulation aids when designing for Universal Access. It concludes...

  3. Mechanical design of NASA Ames Research Center vertical motion simulator

    Science.gov (United States)

    Engelbert, D. F.; Bakke, A. P.; Chargin, M. K.; Vallotton, W. C.

    1976-01-01

    NASA has designed and is constructing a new flight simulator with large vertical travel. Several aspects of the mechanical design of this Vertical Motion Simulator (VMS) are discussed, including the multiple rack and pinion vertical drive, a pneumatic equilibration system, and the friction-damped rigid link catenaries used as cable supports.

  4. GPU-accelerated CFD Simulations for Turbomachinery Design Optimization

    NARCIS (Netherlands)

    Aissa, M.H.

    2017-01-01

    Design optimization relies heavily on time-consuming simulations, especially when using gradient-free optimization methods. These methods require a large number of simulations in order to get a remarkable improvement over reference designs, which are nowadays based on the accumulated engineering

  5. Using the capital markets in Ras Gas

    International Nuclear Information System (INIS)

    Voge, B.; Penzer, M.

    1997-01-01

    In December 1996, Ras Laffan Liquefied Natural Gas Company Ltd (Ras Gas) closed a multi-source financing that included an offering of US$1.2bn of bonds. The sponsors of the Ras Gas project overcame a number of obstacles on the road to closing the capital markets offering. This article provides a general overview of capital markets offerings in international project financings and discusses how Ras Gas was able to successfully integrate a capital markets offering into a financing plan which included a commercial bank facility and several export-credit agency facilities. (Author)

  6. Simulation Packages Expand Aircraft Design Options

    Science.gov (United States)

    2013-01-01

    In 2001, NASA released a new approach to computational fluid dynamics that allows users to perform automated analysis on complex vehicle designs. In 2010, Palo Alto, California-based Desktop Aeronautics acquired a license from Ames Research Center to sell the technology. Today, the product assists organizations in the design of subsonic aircraft, space planes, spacecraft, and high speed commercial jets.

  7. Conceptual Design and Simulation of a Miniature Plasma Focus

    International Nuclear Information System (INIS)

    Jafari, H.; Habibi, M.; Amrollahi, R.

    2012-01-01

    Design and construction of a miniature plasma focus device with 3.6 J of energy bank is reported. In design the device, some of very important parameters of designing such as plasma energy density and derive parameter was used. Regarding to the electrical and geometrical parameters of the device, a simulation is carried out by MATLAB software. Simulation results showed that the formation of the pinch have occurred at the moment of the peak discharge current.

  8. SHIPBUILDING PRODUCTION PROCESS DESIGN METHODOLOGY USING COMPUTER SIMULATION

    OpenAIRE

    Marko Hadjina; Nikša Fafandjel; Tin Matulja

    2015-01-01

    In this research a shipbuilding production process design methodology, using computer simulation, is suggested. It is expected from suggested methodology to give better and more efficient tool for complex shipbuilding production processes design procedure. Within the first part of this research existing practice for production process design in shipbuilding was discussed, its shortcomings and problem were emphasized. In continuing, discrete event simulation modelling method, as basis of sugge...

  9. Simulant Basis for the Standard High Solids Vessel Design

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, Reid A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Fiskum, Sandra K. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Suffield, Sarah R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Daniel, Richard C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Gauglitz, Phillip A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Wells, Beric E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2017-09-30

    The Waste Treatment and Immobilization Plant (WTP) is working to develop a Standard High Solids Vessel Design (SHSVD) process vessel. To support testing of this new design, WTP engineering staff requested that a Newtonian simulant and a non-Newtonian simulant be developed that would represent the Most Adverse Design Conditions (in development) with respect to mixing performance as specified by WTP. The majority of the simulant requirements are specified in 24590-PTF-RPT-PE-16-001, Rev. 0. The first step in this process is to develop the basis for these simulants. This document describes the basis for the properties of these two simulant types. The simulant recipes that meet this basis will be provided in a subsequent document.

  10. Quantitative two-dimensional gel electrophoresis analysis of human fibroblasts transformed by ras oncogenes.

    Science.gov (United States)

    Miller, M J; Maher, V M; McCormick, J J

    1992-11-01

    Quantitative two-dimensional gel electrophoresis was used to compare the cellular protein patterns of a normal foreskin-derived human fibroblasts cell line (LG1) and three immortal derivatives of LG1. One derivative, designated MSU-1.1 VO, was selected for its ability to grow in the absence of serum and is non-tumorigenic in athymic mice. The other two strains were selected for focus-formation following transfection with either Ha-ras or N-ras oncogenes and form high grade malignant tumors. Correspondence and cluster analysis provided a nonbiased estimate of the relative similarity of the different two-dimensional patterns. These techniques separated the gel patterns into three distinct classes: LG1, MSU-1.1 VO, and the ras transformed cell strains. The MSU-1.1 VO cells were more closely related to the parental LG1 than to the ras-transformed cells. The differences between the three classes were primarily quantitative in nature: 16% of the spots demonstrated statistically significant changes (P 2) in the rate of incorporation of radioactive amino acids. The patterns from the two ras-transformed cell strains were similar, and variations in the expression of proteins that occurred between the separate experiments obscured consistent differences between the Ha-ras and N-ras transformed cells. However, while only 9 out of 758 spots were classified as different (1%), correspondence analysis could consistently separate the two ras transformants. One of these spots was five times more intense in the Ha-ras transformed cells than the N-ras.(ABSTRACT TRUNCATED AT 250 WORDS)

  11. Simulation Data Management - Requirements and Design Specification

    Energy Technology Data Exchange (ETDEWEB)

    Clay, Robert L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Friedman-Hill, Ernest J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gibson, Marcus J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hoffman, Edward L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Olson, Kevin H. [Science Applications International Corporation (SAIC), Reston, VA (United States); Laney, Daniel [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-11-01

    Simulation Data Management (SDM), the ability to securely organize, archive, and share analysis models and the artifacts used to create them, is a fundamental requirement for modern engineering analysis based on computational simulation. We have worked separately to provide secure, network SDM services to engineers and scientists at our respective laboratories for over a decade. We propose to leverage our experience and lessons learned to help develop and deploy a next-generation SDM service as part of a multi-laboratory team. This service will be portable across multiple sites and platforms, and will be accessible via a range of command-line tools and well-documented APIs. In this document, we’ll review our high-level and low-level requirements for such a system, review one existing system, and briefly discuss our proposed implementation.

  12. Physiological Based Simulator Fidelity Design Guidance

    Science.gov (United States)

    Schnell, Thomas; Hamel, Nancy; Postnikov, Alex; Hoke, Jaclyn; McLean, Angus L. M. Thom, III

    2012-01-01

    The evolution of the role of flight simulation has reinforced assumptions in aviation that the degree of realism in a simulation system directly correlates to the training benefit, i.e., more fidelity is always better. The construct of fidelity has several dimensions, including physical fidelity, functional fidelity, and cognitive fidelity. Interaction of different fidelity dimensions has an impact on trainee immersion, presence, and transfer of training. This paper discusses research results of a recent study that investigated if physiological-based methods could be used to determine the required level of simulator fidelity. Pilots performed a relatively complex flight task consisting of mission task elements of various levels of difficulty in a fixed base flight simulator and a real fighter jet trainer aircraft. Flight runs were performed using one forward visual channel of 40 deg. field of view for the lowest level of fidelity, 120 deg. field of view for the middle level of fidelity, and unrestricted field of view and full dynamic acceleration in the real airplane. Neuro-cognitive and physiological measures were collected under these conditions using the Cognitive Avionics Tool Set (CATS) and nonlinear closed form models for workload prediction were generated based on these data for the various mission task elements. One finding of the work described herein is that simple heart rate is a relatively good predictor of cognitive workload, even for short tasks with dynamic changes in cognitive loading. Additionally, we found that models that used a wide range of physiological and neuro-cognitive measures can further boost the accuracy of the workload prediction.

  13. Design and Test of Advanced Thermal Simulators for an Alkali Metal-Cooled Reactor Simulator

    Science.gov (United States)

    Garber, Anne E.; Dickens, Ricky E.

    2011-01-01

    The Early Flight Fission Test Facility (EFF-TF) at NASA Marshall Space Flight Center (MSFC) has as one of its primary missions the development and testing of fission reactor simulators for space applications. A key component in these simulated reactors is the thermal simulator, designed to closely mimic the form and function of a nuclear fuel pin using electric heating. Continuing effort has been made to design simple, robust, inexpensive thermal simulators that closely match the steady-state and transient performance of a nuclear fuel pin. A series of these simulators have been designed, developed, fabricated and tested individually and in a number of simulated reactor systems at the EFF-TF. The purpose of the thermal simulators developed under the Fission Surface Power (FSP) task is to ensure that non-nuclear testing can be performed at sufficiently high fidelity to allow a cost-effective qualification and acceptance strategy to be used. Prototype thermal simulator design is founded on the baseline Fission Surface Power reactor design. Recent efforts have been focused on the design, fabrication and test of a prototype thermal simulator appropriate for use in the Technology Demonstration Unit (TDU). While designing the thermal simulators described in this paper, effort were made to improve the axial power profile matching of the thermal simulators. Simultaneously, a search was conducted for graphite materials with higher resistivities than had been employed in the past. The combination of these two efforts resulted in the creation of thermal simulators with power capacities of 2300-3300 W per unit. Six of these elements were installed in a simulated core and tested in the alkali metal-cooled Fission Surface Power Primary Test Circuit (FSP-PTC) at a variety of liquid metal flow rates and temperatures. This paper documents the design of the thermal simulators, test program, and test results.

  14. Design of specimen for weld residual stress simulation

    International Nuclear Information System (INIS)

    Kim, Jin Weon; Park, Jong Sun; Lee, Kyung Soo

    2008-01-01

    The objective of this study is to design a laboratory specimen for simulating residual stress of circumferential butt welding of pipe. Specimen type and method for residual stress generation were proposed based on the review of prior studies and parametric finite element simulation. To prove the proposed specimen type and loading method, the residual stress was generated using the designed specimen by applying proposed method and was measured. The measured residual stress using X-ray diffraction reasonably agreed with the results of finite element simulation considered in the specimen design. Comparison of residual strains measured at several locations of specimen and given by finite element simulation also showed good agreement. Therefore, it is indicated that the designed specimen can reasonably simulate the residual stress of circumferential butt welding of pipe

  15. Design and Analysis of Solar Smartflower Simulation by Solidwork Program

    Science.gov (United States)

    Mulyana, Tatang; Sebayang, Darwin; Fajrina, Fildzah; Raihan; Faizal, M.

    2018-03-01

    The potential of solar energy that is so large in Indonesia can be a driving force for the use of renewable energy as a solution for energy needs. Government with the community can utilize and optimize this technology to increase the electrification ratio up to 100% in all corners of Indonesia. Because of its modular and practical nature, making this technology easy to apply. One of the latest imported products that have started to be offered and sold in Indonesia but not yet widely used for solar power generation is the kind of smartflower. Before using the product, it is of course very important and immediately to undertake an in-depth study of the utilization, use, maintenance, repair, component supply and fabrication. The best way to know the above is through a review of the design and simulation. To meet this need, this paper presents a solar-smartflower design and then simulated using the facilities available in the solidwork program. Solid simulation express is a tool that serves to create power simulation of a design part modelling. With the simulation is very helpful at all to reduce errors in making design. Accurate or not a design created is also influenced by several other factors such as material objects, the silent part of the part, and the load given. The simulation is static simulation and body battery drop test, and based on the results of this simulation is known that the design results have been very satisfactory.

  16. Integrated computer aided design simulation and manufacture

    OpenAIRE

    Diko, Faek

    1989-01-01

    Computer Aided Design (CAD) and Computer Aided Manufacture (CAM) have been investigated and developed since twenty years as standalone systems. A large number of very powerful but independent packages have been developed for Computer Aided Design,Aanlysis and Manufacture. However, in most cases these packages have poor facility for communicating with other packages. Recently attempts have been made to develop integrated CAD/CAM systems and many software companies a...

  17. Evaluation of Control and Adjustment Structures of the Shibab Main Canal Using HEC-RAS

    Directory of Open Access Journals (Sweden)

    maryam mohammadi

    2017-02-01

    existing structures on the Shibab main canal. HEC-RAS model was prepared by United States army corps of engineers which is developed by the hydrologicengineering center.HEC-RAS analyzes river system and runs under the Windows operating system. This software package is of hydraulic analysis program series, where the user communicates with the system via a graphical user interface (GUI. The system is capable of performing steady and unsteady flow water surfaceprofile calculations. HEC-RAS software is designed to perform one dimensional hydraulic calculation for a full network of natural and synthetic channels. Visits were made before and after the beginning of irrigation, and during the Operation, in order to record the data of the flow and observe the way of utilization of canal, and existing structures. Then, the model was calibrated on the basis of depth and discharge measurement and simulation data in real condition of operation for 10 days impoundment during 21 to 30 April, and the Statistical parameter values:RMSE, EF, MBEand R2 were calculated. Then the objective functionwas evaluatedusingoperational performance indexes of adequacy, efficiency, equity and reliability of Molden and Gates regarding to HEC-RAS simulation results in unsteady condition. Results and Discussion: According to the simulation results in existing condition,theerror of delivery dischargeis equal to 0.54 while applying the management onthe adjustment structure of irrigation networkdeclined theerror to 0.42. By the canal routstructuremanagement in HEC-RAS model, on the basis of proposed operation option, according to existing operation condition, delivery discharge loss in comparison to the total discharge of the network 0.12 value decreases.Based on the simulation results, the mean percentage of improvementin performance indexes of adequacy,efficiency, equity and reliability, as well as objective functionofdelivery discharge are equal to 19.7, 20.90, 66.07, 65.24and54.81. Therefore based on

  18. Hierarchical Network Design Using Simulated Annealing

    DEFF Research Database (Denmark)

    Thomadsen, Tommy; Clausen, Jens

    2002-01-01

    networks are described and a mathematical model is proposed for a two level version of the hierarchical network problem. The problem is to determine which edges should connect nodes, and how demand is routed in the network. The problem is solved heuristically using simulated annealing which as a sub......-algorithm uses a construction algorithm to determine edges and route the demand. Performance for different versions of the algorithm are reported in terms of runtime and quality of the solutions. The algorithm is able to find solutions of reasonable quality in approximately 1 hour for networks with 100 nodes....

  19. Automated simulation and study of spatial-structural design processes

    NARCIS (Netherlands)

    Davila Delgado, J.M.; Hofmeyer, H.; Stouffs, R.; Sariyildiz, S.

    2013-01-01

    A so-called "Design Process Investigation toolbox" (DPI toolbox), has been developed. It is a set of computational tools that simulate spatial-structural design processes. Its objectives are to study spatial-structural design processes and to support the involved actors. Two case-studies are

  20. Mindfully implementing simulation tools for supporting pragmatic design inquiries

    NARCIS (Netherlands)

    Hartmann, Timo; olde Scholtenhuis, Léon Luc; Zerjav, Vedran; Champlin, Carissa J

    2015-01-01

    Based upon a conceptualization of the engineering design process as pragmatic inquiry, this paper introduces a framework for supporting designers and design managers with a better understanding of the trade-offs required for a successful implementation of simulation tools. This framework contributes

  1. Technology computer aided design simulation for VLSI MOSFET

    CERN Document Server

    Sarkar, Chandan Kumar

    2013-01-01

    Responding to recent developments and a growing VLSI circuit manufacturing market, Technology Computer Aided Design: Simulation for VLSI MOSFET examines advanced MOSFET processes and devices through TCAD numerical simulations. The book provides a balanced summary of TCAD and MOSFET basic concepts, equations, physics, and new technologies related to TCAD and MOSFET. A firm grasp of these concepts allows for the design of better models, thus streamlining the design process, saving time and money. This book places emphasis on the importance of modeling and simulations of VLSI MOS transistors and

  2. White light signal simulator microcontroller design | Haghighi ...

    African Journals Online (AJOL)

    In this research, first through experimental studies, the recorded signals associated with the light white from human retina cells were digitized, then the digital data were calculated and the resulted mathematical equation was programmed on a microcontroller, and by designing a circuit, the output voltage over time similar to ...

  3. Molecular interaction between K-Ras and H-REV107 in the Ras signaling pathway.

    Science.gov (United States)

    Han, Chang Woo; Jeong, Mi Suk; Jang, Se Bok

    2017-09-16

    Ras proteins are small GTPases that serve as master moderators of a large number of signaling pathways involved in various cellular processes. Activating mutations in Ras are found in about one-third of cancers. H-REV107, a K-Ras binding protein, plays an important role in determining K-Ras function. H-REV107 is a member of the HREV107 family of class II tumor suppressor genes and a growth inhibitory Ras target gene that suppresses cellular growth, differentiation, and apoptosis. Expression of H-REV107 was strongly reduced in about 50% of human carcinoma cell lines. However, the specific molecular mechanism by which H-REV107 inhibits Ras is still unknown. In the present study, we suggest that H-REV107 forms a strong complex with activating oncogenic mutation Q61H K-Ras from various biochemical binding assays and modeled structures. In addition, the interaction sites between K-Ras and H-REV107 were predicted based on homology modeling. Here, we found that some structure-based mutants of the K-Ras disrupted the complex formation with H-REV107. Finally, a novel molecular mechanism describing K-Ras and H-REV107 binding is suggested and insights into new K-Ras effector target drugs are provided. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. A Simulation Approach for Performance Validation during Embedded Systems Design

    Science.gov (United States)

    Wang, Zhonglei; Haberl, Wolfgang; Herkersdorf, Andreas; Wechs, Martin

    Due to the time-to-market pressure, it is highly desirable to design hardware and software of embedded systems in parallel. However, hardware and software are developed mostly using very different methods, so that performance evaluation and validation of the whole system is not an easy task. In this paper, we propose a simulation approach to bridge the gap between model-driven software development and simulation based hardware design, by merging hardware and software models into a SystemC based simulation environment. An automated procedure has been established to generate software simulation models from formal models, while the hardware design is originally modeled in SystemC. As the simulation models are annotated with timing information, performance issues are tackled in the same pass as system functionality, rather than in a dedicated approach.

  5. Modeling and Simulation for Mission Operations Work System Design

    Science.gov (United States)

    Sierhuis, Maarten; Clancey, William J.; Seah, Chin; Trimble, Jay P.; Sims, Michael H.

    2003-01-01

    Work System analysis and design is complex and non-deterministic. In this paper we describe Brahms, a multiagent modeling and simulation environment for designing complex interactions in human-machine systems. Brahms was originally conceived as a business process design tool that simulates work practices, including social systems of work. We describe our modeling and simulation method for mission operations work systems design, based on a research case study in which we used Brahms to design mission operations for a proposed discovery mission to the Moon. We then describe the results of an actual method application project-the Brahms Mars Exploration Rover. Space mission operations are similar to operations of traditional organizations; we show that the application of Brahms for space mission operations design is relevant and transferable to other types of business processes in organizations.

  6. Conceptual design for simulator of irradiation test reactors

    International Nuclear Information System (INIS)

    Takemoto, Noriyuki; Ohto, Tsutomu; Magome, Hirokatsu; Izumo, Hironobu; Hori, Naohiko

    2012-03-01

    A simulator of irradiation test reactors has been developed since JFY 2010 for understanding reactor behavior and for upskilling in order to utilize a nuclear human resource development (HRD) and to promote partnership with developing countries which have a plan to introduce nuclear power plant. The simulator is designed based on the JMTR, one of the irradiation test reactors, and it simulates operation, irradiation tests and various kinds of accidents caused by the reactor and irradiation facility. The development of the simulator is sponsored by the Japanese government as one of the specialized projects of advanced research infrastructure in order to promote basic as well as applied researches. The training using the simulator will be started for the nuclear HRD from JFY 2012. This report summarizes the result of the conceptual design of the simulator in JFY 2010. (author)

  7. Simulation-enhanced lean design process

    Directory of Open Access Journals (Sweden)

    Jon H. Marvel

    2009-07-01

    Full Text Available 72 Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} A traditional lean transformation process does not validate the future state before implementation, relying instead on a series of iterations to modify the system until performance is satisfactory. An enhanced lean process that includes future state validation before implementation is presented.  Simulation modeling and experimentation is proposed as the primary validation tool.  Simulation modeling and experimentation extends value stream mapping to include time, the behavior of individual entities, structural variability, random variability, and component interaction effects. Experiments to analyze the model and draw conclusions about whether the lean transformation effectively addresses the current state gap can be conducted.  Industrial applications of the enhanced lean process show it effectiveness.

  8. Toward Designing a Quantum Key Distribution Network Simulation Model

    OpenAIRE

    Miralem Mehic; Peppino Fazio; Miroslav Voznak; Erik Chromy

    2016-01-01

    As research in quantum key distribution network technologies grows larger and more complex, the need for highly accurate and scalable simulation technologies becomes important to assess the practical feasibility and foresee difficulties in the practical implementation of theoretical achievements. In this paper, we described the design of simplified simulation environment of the quantum key distribution network with multiple links and nodes. In such simulation environment, we analyzed several ...

  9. Design of biped hip simulator using SolidWorks

    Science.gov (United States)

    Zainudin, M. R.; Yahya, A.; Fazli, M. I. M.; Syahrom, A.; Harun, F. K. C.; Nazarudin, M. S.

    2017-10-01

    The increasing number of people who underwent both hip implant surgery based on World Health Organization (WHO) has received massive attention from researchers lately to develop various types of hip simulators in order to test the hip implant. Various number of hip simulator have been developed with different functions and capabilities. This paper presents the design development of biped hip simulator using SolidWorks software by taking into consideration some improvement and modifications. The finite element method is used to test the design whether it is safe to be used or not. The biped hip simulator has been successfully designed and ready to be fabricated as the endurance testing shown a positive results. The von Mises stress induced in the material is an alloy steel which is 2,975,862.3 N/m2 lower than the yield strength. Thus, the design is safe to be used as it obey the safety criterion.

  10. WDM Systems and Networks Modeling, Simulation, Design and Engineering

    CERN Document Server

    Ellinas, Georgios; Roudas, Ioannis

    2012-01-01

    WDM Systems and Networks: Modeling, Simulation, Design and Engineering provides readers with the basic skills, concepts, and design techniques used to begin design and engineering of optical communication systems and networks at various layers. The latest semi-analytical system simulation techniques are applied to optical WDM systems and networks, and a review of the various current areas of optical communications is presented. Simulation is mixed with experimental verification and engineering to present the industry as well as state-of-the-art research. This contributed volume is divided into three parts, accommodating different readers interested in various types of networks and applications. The first part of the book presents modeling approaches and simulation tools mainly for the physical layer including transmission effects, devices, subsystems, and systems), whereas the second part features more engineering/design issues for various types of optical systems including ULH, access, and in-building system...

  11. Estimation of Channel-Forming Discharge and Large-Event Geomorphic Response Using HEC-RAS

    Science.gov (United States)

    Hamilton, P.; Strom, K.; Hosseiny, S. M. H.

    2015-12-01

    The goal of the present work was to consider the functionality and applicability of HEC-RAS sediment transport simulations in two situations. The first was as a mode for obtaining quick estimates of the effective discharge, one measure of channel-forming discharge, and the second was as a mode to quickly estimate sediment transport and the commensurate potential erosion and deposition during large flood events. Though there are many other sediment transport and morphodynamic models available, e.g., CCHE1D, Nays2DH, we were interested in using HEC-RAS since this is the model of choice for many regulatory bodies, e.g., FEMA, cities, and counties. This makes using the sediment transport capability of HEC-RAS a natural extension of models that already otherwise exist and are well calibrated. In first looking at the utility of these models, we wanted to estimate the effective discharge of streams. Effective discharge is one way of defining the channel-forming discharge for a stream and is therefore an important parameter in natural channel design and restoration efforts. By running this range of floods, one can easily obtain an estimate for recurrence interval most responsible for moving the majority of sediment over a long time period. Results were compared to data collected within our research group on the Brazos River (TX). Effective discharge is an important estimate, particularly in understanding the equilibrium channel condition. Nevertheless, large floods are contemporaneously catastrophic and understanding their potential effects is desirable. Finally, we performed some sensitivity analysis to better understand the underlying assumptions of the various sediment transport model options and how they might affect the outcome of the aforementioned computations.

  12. Simulation in the Service of Design - Asking the Right Questions

    Energy Technology Data Exchange (ETDEWEB)

    Donn, Michael; Selkowitz, Stephen; Bordass, Bill

    2009-03-01

    This paper proposes an approach to the creation of design tools that address the real information needs of designers in the early stages of design of nonresidential buildings. Traditional simplified design tools are typically too limited to be of much use, even in conceptual design. The proposal is to provide access to the power of detailed simulation tools, at a stage in design when little is known about the final building, but at a stage also when the freedom to explore options is greatest. The proposed approach to tool design has been derived from consultation with design analysis teams as part of the COMFEN tool development. The paper explores how tools like COMFEN have been shaped by this consultation and how requests from these teams for real-world relevance might shape such tools in the future, drawing into the simulation process the lessons from Post Occupancy Evaluation (POE) of buildings.

  13. Experimental Design for Sensitivity Analysis of Simulation Models

    NARCIS (Netherlands)

    Kleijnen, J.P.C.

    2001-01-01

    This introductory tutorial gives a survey on the use of statistical designs for what if-or sensitivity analysis in simulation.This analysis uses regression analysis to approximate the input/output transformation that is implied by the simulation model; the resulting regression model is also known as

  14. Westinghouse Nuclear Core Design Training Center - a design simulator

    International Nuclear Information System (INIS)

    Altomare, S.; Pritchett, J.; Altman, D.

    1992-01-01

    The emergence of more powerful computing technology enables nuclear design calculations to be done on workstations. This shift to workstation usage has already had a profound effect in the training area. In 1991, the Westinghouse Electric Corporation's Commercial Nuclear Fuel Division (CNFD) developed and implemented a Nuclear Core Design Training Center (CDTC), a new concept in on-the-job training. The CDTC provides controlled on-the-job training in a structured classroom environment. It alllows one trainer, with the use of a specially prepared training facility, to provide full-scope, hands-on training to many trainees at one time. Also, the CDTC system reduces the overall cycle time required to complete the total training experience while also providing the flexibility of individual training in selected modules of interest. This paper provides descriptions of the CDTC and the respective experience gained in the application of this new concept

  15. Simulation Experiments in Practice: Statistical Design and Regression Analysis

    OpenAIRE

    Kleijnen, J.P.C.

    2007-01-01

    In practice, simulation analysts often change only one factor at a time, and use graphical analysis of the resulting Input/Output (I/O) data. The goal of this article is to change these traditional, naïve methods of design and analysis, because statistical theory proves that more information is obtained when applying Design Of Experiments (DOE) and linear regression analysis. Unfortunately, classic DOE and regression analysis assume a single simulation response that is normally and independen...

  16. Design and use of an engineering simulator for power plant and training simulator updates

    International Nuclear Information System (INIS)

    Sharawy, P.S.; Kennard, J.R.; Chou, Q.B.

    1990-01-01

    The advancement in real-time simulators has been facilitated by the availability of increasingly powerful computing devices at reduced costs for use in conjunction with high-fidelity simulation software. Ontario Hydro's commitment to the safe and reliable operation of its nuclear power plants was one of the factors which influenced its decision to build a plant-replica operator training simulator for each of its nuclear generating stations. This investment soon proved to have advantages beyond those originally envisaged. It become apparent that because the software developed for these simulators met rigorous acceptance criteria, it could be used on an engineering simulator to effectively investigate problems occurring at the stations. It could also serve as a design aid for station modifications. Encouraged by the success of early experimentation in the use of its training simulators for concept validation and verification, Ontario Hydro is developing a low-cost central facility - the Instrumentation and Control Engineering Simulator (ICES) - for use in its design work. This facility incorporates the software of its training simulators and includes a user-friendly generic interface which enables designers to configure and operate it. Inclusion of the engineering simulator in all phases of the design process, from the original concept to implementation and verification, will make it possible to shorten the design period significantly while achieving a high level of quality. It will also facilitate the rapid retrofit of simulators to reflect station modifications. This paper will recount Ontario Hydro's experience in the use of simulators for design work and will specifically discuss the design features and system performance of its engineering simulator

  17. SINERGIA laparoscopic virtual reality simulator: didactic design and technical development.

    Science.gov (United States)

    Lamata, Pablo; Gómez, Enrique J; Sánchez-Margallo, Francisco M; López, Oscar; Monserrat, Carlos; García, Verónica; Alberola, Carlos; Florido, Miguel Angel Rodríguez; Ruiz, Juan; Usón, Jesús

    2007-03-01

    VR laparoscopic simulators have demonstrated its validity in recent studies, and research should be directed towards a high training effectiveness and efficacy. In this direction, an insight into simulators' didactic design and technical development is provided, by describing the methodology followed in the building of the SINERGIA simulator. It departs from a clear analysis of training needs driven by a surgical training curriculum. Existing solutions and validation studies are an important reference for the definition of specifications, which are described with a suitable use of simulation technologies. Five new didactic exercises are proposed to train some of the basic laparoscopic skills. Simulator construction has required existing algorithms and the development of a particle-based biomechanical model, called PARSYS, and a collision handling solution based in a multi-point strategy. The resulting VR laparoscopic simulator includes new exercises and enhanced simulation technologies, and is finding a very good acceptance among surgeons.

  18. Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway

    International Nuclear Information System (INIS)

    Tseng, Ya-Shih; Lee, Jenq-Chang; Huang, Chi-Ying F; Liu, Hsiao-Sheng

    2009-01-01

    Overexpression of Aurora-A and mutant Ras (Ras V12 ) together has been detected in human bladder cancer tissue. However, it is not clear whether this phenomenon is a general event or not. Although crosstalk between Aurora-A and Ras signaling pathways has been reported, the role of these two genes acting together in tumorigenesis remains unclear. Real-time PCR and sequence analysis were utilized to identify Ha- and Ki-ras mutation (Gly -> Val). Immunohistochemistry staining was used to measure the level of Aurora-A expression in bladder and colon cancer specimens. To reveal the effect of overexpression of the above two genes on cellular responses, mouse NIH3T3 fibroblast derived cell lines over-expressing either Ras V12 and wild-type Aurora-A (designated WT) or Ras V12 and kinase-inactivated Aurora-A (KD) were established. MTT and focus formation assays were conducted to measure proliferation rate and focus formation capability of the cells. Small interfering RNA, pharmacological inhibitors and dominant negative genes were used to dissect the signaling pathways involved. Overexpression of wild-type Aurora-A and mutation of Ras V12 were detected in human bladder and colon cancer tissues. Wild-type Aurora-A induces focus formation and aggregation of the Ras V12 transformants. Aurora-A activates Ral A and the phosphorylation of AKT as well as enhances the phosphorylation of MEK, ERK of WT cells. Finally, the Ras/MEK/ERK signaling pathway is responsible for Aurora-A induced aggregation of the Ras V12 transformants. Wild-type-Aurora-A enhances focus formation and aggregation of the Ras V12 transformants and the latter occurs through modulating the Ras/MEK/ERK signaling pathway

  19. Application of HEC-RAS water quality model to estimate contaminant spreading in small stream

    Energy Technology Data Exchange (ETDEWEB)

    Halaj, Peter; Bárek, Viliam; Halajová, Anna Báreková; Halajová, Denisa [Slovak University of Agriculture in Nitra, Nitra (Slovakia)

    2013-07-01

    The paper presents study of some aspects of HEC-RAS water quality model connected to simulation of contaminant transport in small stream. Authors mainly focused on one of the key tasks in process of pollutant transport modelling in streams - determination of the dispersion characteristics represented by longitudinal dispersion coefficient D. Different theoretical and empirical formulas have been proposed for D value determination and they have revealed that the coefficient is variable parameter that depends on hydraulic and morphometric characteristics of the stream reaches. Authors compare the results of several methods of coefficient D assessment, assuming experimental data obtained by tracer studies and compare them with results optimized by HEC-RAS water quality model. The analyses of tracer study and computation outputs allow us to outline the important aspects of longitudinal dispersion coefficient set up in process of the HEC-RAS model use. Key words: longitudinal dispersion coefficient, HEC-RAS, water quality modeling.

  20. Learning Reverse Engineering and Simulation with Design Visualization

    Science.gov (United States)

    Hemsworth, Paul J.

    2018-01-01

    The Design Visualization (DV) group supports work at the Kennedy Space Center by utilizing metrology data with Computer-Aided Design (CAD) models and simulations to provide accurate visual representations that aid in decision-making. The capability to measure and simulate objects in real time helps to predict and avoid potential problems before they become expensive in addition to facilitating the planning of operations. I had the opportunity to work on existing and new models and simulations in support of DV and NASA’s Exploration Ground Systems (EGS).

  1. Instructional psychology and the design of training simulators

    International Nuclear Information System (INIS)

    Stammers, R.B.

    1985-01-01

    In this paper the role of instructional psychology in simulator design and use is discussed. It is suggested that research and development work has tended to focus upon the face validity of simulators rather than their instructional utility. Dimensions of simulation are reviewed as are the variety of uses to which a simulator may be put. The nature of instructional psychology is briefly described under the following headings: task analysis, the acquisition of knowledge and skill and theories of instruction. Attention is also given to the potential role of computer-based training and the topic of retention of training is introduced. (author)

  2. Toward Designing a Quantum Key Distribution Network Simulation Model

    Directory of Open Access Journals (Sweden)

    Miralem Mehic

    2016-01-01

    Full Text Available As research in quantum key distribution network technologies grows larger and more complex, the need for highly accurate and scalable simulation technologies becomes important to assess the practical feasibility and foresee difficulties in the practical implementation of theoretical achievements. In this paper, we described the design of simplified simulation environment of the quantum key distribution network with multiple links and nodes. In such simulation environment, we analyzed several routing protocols in terms of the number of sent routing packets, goodput and Packet Delivery Ratio of data traffic flow using NS-3 simulator.

  3. Design of simulation-based medical education and advantages and disadvantages of in situ simulation versus off-site simulation.

    Science.gov (United States)

    Sørensen, Jette Led; Østergaard, Doris; LeBlanc, Vicki; Ottesen, Bent; Konge, Lars; Dieckmann, Peter; Van der Vleuten, Cees

    2017-01-21

    Simulation-based medical education (SBME) has traditionally been conducted as off-site simulation in simulation centres. Some hospital departments also provide off-site simulation using in-house training room(s) set up for simulation away from the clinical setting, and these activities are called in-house training. In-house training facilities can be part of hospital departments and resemble to some extent simulation centres but often have less technical equipment. In situ simulation, introduced over the past decade, mainly comprises of team-based activities and occurs in patient care units with healthcare professionals in their own working environment. Thus, this intentional blend of simulation and real working environments means that in situ simulation brings simulation to the real working environment and provides training where people work. In situ simulation can be either announced or unannounced, the latter also known as a drill. This article presents and discusses the design of SBME and the advantage and disadvantage of the different simulation settings, such as training in simulation-centres, in-house simulations in hospital departments, announced or unannounced in situ simulations. Non-randomised studies argue that in situ simulation is more effective for educational purposes than other types of simulation settings. Conversely, the few comparison studies that exist, either randomised or retrospective, show that choice of setting does not seem to influence individual or team learning. However, hospital department-based simulations, such as in-house simulation and in situ simulation, lead to a gain in organisational learning. To our knowledge no studies have compared announced and unannounced in situ simulation. The literature suggests some improved organisational learning from unannounced in situ simulation; however, unannounced in situ simulation was also found to be challenging to plan and conduct, and more stressful among participants. The importance of

  4. Using interactive model simulations in co-design : An experiment in urban design

    NARCIS (Netherlands)

    Steen, M.G.D.; Arendsen, J.; Cremers, A.H.M.; Vries, A. de; Jong, J.M.G. de; Koning, N.M. de

    2013-01-01

    This paper presents an experiment in which people performed a co-design task in urban design, using a multi-user touch table application with or without interactive model simulations. We hypothesised that using the interactive model simulations would improve communication and co-operation between

  5. Simulation-based optimization for product and process design

    NARCIS (Netherlands)

    Driessen, L.

    2006-01-01

    The design of products and processes has gradually shifted from a purely physical process towards a process that heavily relies on computer simulations (virtual prototyping). To optimize this virtual design process in terms of speed and final product quality, statistical methods and mathematical

  6. Design of a PWR emergency core cooling simulator loop

    International Nuclear Information System (INIS)

    Melo, C.A. de.

    1982-12-01

    The preliminary design of a PWR Emergency Core Cooling Simulator Loop for investigations of the phenomena involved in a postulated Loss-of-Coolant Accident, during the Reflooding Phase, is presented. The functions of each component of the loop, the design methods and calculations, the specification of the instrumentation, the system operation sequence, the materials list and a cost assessment are included. (Author) [pt

  7. Advanced Simulation and Computing Co-Design Strategy

    Energy Technology Data Exchange (ETDEWEB)

    Ang, James A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hoang, Thuc T. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Kelly, Suzanne M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); McPherson, Allen [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Neely, Rob [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-11-01

    This ASC Co-design Strategy lays out the full continuum and components of the co-design process, based on what we have experienced thus far and what we wish to do more in the future to meet the program’s mission of providing high performance computing (HPC) and simulation capabilities for NNSA to carry out its stockpile stewardship responsibility.

  8. Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence*

    Science.gov (United States)

    Vo, Uybach; Vajpai, Navratna; Flavell, Liz; Bobby, Romel; Breeze, Alexander L.; Embrey, Kevin J.; Golovanov, Alexander P.

    2016-01-01

    The activity of Ras is controlled by the interconversion between GTP- and GDP-bound forms partly regulated by the binding of the guanine nucleotide exchange factor Son of Sevenless (Sos). The details of Sos binding, leading to nucleotide exchange and subsequent dissociation of the complex, are not completely understood. Here, we used uniformly 15N-labeled Ras as well as [13C]methyl-Met,Ile-labeled Sos for observing site-specific details of Ras-Sos interactions in solution. Binding of various forms of Ras (loaded with GDP and mimics of GTP or nucleotide-free) at the allosteric and catalytic sites of Sos was comprehensively characterized by monitoring signal perturbations in the NMR spectra. The overall affinity of binding between these protein variants as well as their selected functional mutants was also investigated using intrinsic fluorescence. The data support a positive feedback activation of Sos by Ras·GTP with Ras·GTP binding as a substrate for the catalytic site of activated Sos more weakly than Ras·GDP, suggesting that Sos should actively promote unidirectional GDP → GTP exchange on Ras in preference of passive homonucleotide exchange. Ras·GDP weakly binds to the catalytic but not to the allosteric site of Sos. This confirms that Ras·GDP cannot properly activate Sos at the allosteric site. The novel site-specific assay described may be useful for design of drugs aimed at perturbing Ras-Sos interactions. PMID:26565026

  9. H-Ras and K-Ras Oncoproteins Induce Different Tumor Spectra When Driven by the Same Regulatory Sequences.

    Science.gov (United States)

    Drosten, Matthias; Simón-Carrasco, Lucía; Hernández-Porras, Isabel; Lechuga, Carmen G; Blasco, María T; Jacob, Harrys K C; Fabbiano, Salvatore; Potenza, Nicoletta; Bustelo, Xosé R; Guerra, Carmen; Barbacid, Mariano

    2017-02-01

    Genetic studies in mice have provided evidence that H-Ras and K-Ras proteins are bioequivalent. However, human tumors display marked differences in the association of RAS oncogenes with tumor type. Thus, to further assess the bioequivalence of oncogenic H-Ras and K-Ras, we replaced the coding region of the murine K-Ras locus with H-Ras G12V oncogene sequences. Germline expression of H-Ras G12V or K-Ras G12V from the K-Ras locus resulted in embryonic lethality. However, expression of these genes in adult mice led to different tumor phenotypes. Whereas H-Ras G12V elicited papillomas and hematopoietic tumors, K-Ras G12V induced lung tumors and gastric lesions. Pulmonary expression of H-Ras G12V created a senescence-like state caused by excessive MAPK signaling. Likewise, H-Ras G12V but not K-Ras G12V induced senescence in mouse embryonic fibroblasts. Label-free quantitative analysis revealed that minor differences in H-Ras G12V expression levels led to drastically different biological outputs, suggesting that subtle differences in MAPK signaling confer nonequivalent functions that influence tumor spectra induced by RAS oncoproteins. Cancer Res; 77(3); 707-18. ©2016 AACR. ©2016 American Association for Cancer Research.

  10. Lead identification for the K-Ras protein: virtual screening and combinatorial fragment-based approaches

    Directory of Open Access Journals (Sweden)

    Pathan AAK

    2016-05-01

    Full Text Available Akbar Ali Khan Pathan,1,2,* Bhavana Panthi,3,* Zahid Khan,1 Purushotham Reddy Koppula,4–6 Mohammed Saud Alanazi,1 Sachchidanand,3 Narasimha Reddy Parine,1 Mukesh Chourasia3,* 1Genome Research Chair (GRC, Department of Biochemistry, College of Science, King Saud University, 2Integrated Gulf Biosystems, Riyadh, Kingdom of Saudi Arabia; 3Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research, Hajipur, India; 4Department of Internal Medicine, School of Medicine, 5Harry S. Truman Memorial Veterans Affairs Hospital, 6Department of Radiology, School of Medicine, Columbia, MO, USA *These authors contributed equally to this work Objective: Kirsten rat sarcoma (K-Ras protein is a member of Ras family belonging to the small guanosine triphosphatases superfamily. The members of this family share a conserved structure and biochemical properties, acting as binary molecular switches. The guanosine triphosphate-bound active K-Ras interacts with a range of effectors, resulting in the stimulation of downstream signaling pathways regulating cell proliferation, differentiation, and apoptosis. Efforts to target K-Ras have been unsuccessful until now, placing it among high-value molecules against which developing a therapy would have an enormous impact. K-Ras transduces signals when it binds to guanosine triphosphate by directly binding to downstream effector proteins, but in case of guanosine diphosphate-bound conformation, these interactions get disrupted. Methods: In the present study, we targeted the nucleotide-binding site in the “on” and “off” state conformations of the K-Ras protein to find out suitable lead compounds. A structure-based virtual screening approach has been used to screen compounds from different databases, followed by a combinatorial fragment-based approach to design the apposite lead for the K-Ras protein. Results: Interestingly, the designed compounds exhibit a binding preference for the

  11. Regulation of Ras exchange factors and cellular localization of Ras activation by lipid messengers in T cells

    Directory of Open Access Journals (Sweden)

    Jesse E. Jun

    2013-09-01

    Full Text Available The Ras-MAPK signaling pathway is highly conserved throughout evolution and is activated downstream of a wide range of receptor stimuli. Ras guanine nucleotide exchange factors (RasGEFs catalyze GTP loading of Ras and play a pivotal role in regulating receptor-ligand induced Ras activity. In T cells, three families of functionally important RasGEFs are expressed: RasGRF, RasGRP, and SOS-family GEFs.Early on it was recognized that Ras activation is critical for T cell development and that the RasGEFs play an important role herein. More recent work has revealed that nuances in Ras activation appear to significantly impact T cell development and selection. These nuances include distinct biochemical patterns of analog versus digital Ras activation, differences in cellular localization of Ras activation, and intricate interplays between the RasGEFs during distinct T cell developmental stages as revealed by various new mouse models. In many instances, the exact nature of these nuances in Ras activation or how these may result from fine-tuning of the RasGEFs is not understood.One large group of biomolecules critically involved in the control of Ras-GEFs´functions are lipid second messengers. Multiple, yet distinct lipid products are generated following T cell receptor (TCR stimulation and bind to different domains in the RasGRP and SOS RasGEFs to facilitate the activation of the membrane-anchored Ras GTPases. In this review we highlight how different lipid-based elements are generated by various enzymes downstream of the TCR and other receptors and how these dynamic and interrelated lipid products may fine-tune Ras activation by RasGEFs in developing T cells.

  12. A Dynamical Training and Design Simulator for Active Catheters

    Directory of Open Access Journals (Sweden)

    Georges Dumont

    2008-11-01

    Full Text Available This work addresses the design of an active multi-link micro-catheter actuated by Shape Memory Alloy (SMA micro actuators. This may be a response to one medical major demand on such devices, which will be useful for surgical explorations and interventions. In this paper, we focus on a training and design simulator dedicated to such catheters. This simulator is based on an original simulation platform (OpenMASK. The catheter is a robotic system, which is evaluated by a dynamical simulation addressing a navigation task in its environment. The design of the prototype and its mechanical model are presented. We develop an interaction model for contact. This model uses a real medical database for which distance cartography is proposed. Then we focus on an autonomous control model based on a multi-agent approach and including the behaviour description of the SMA actuators. Results of mechanical simulations including interaction with the ducts are presented. Furthermore, the interest of such a simulator is presented by applying virtual prototyping techniques for the design optimization. This optimization process is achieved by using genetic algorithms at different stages with respect to the specified task.

  13. A Dynamical Training and Design Simulator for Active Catheters

    Directory of Open Access Journals (Sweden)

    Georges Dumont

    2004-12-01

    Full Text Available This work addresses the design of an active multi-link micro-catheter actuated by Shape Memory Alloy (SMA micro actuators. This may be a response to one medical major demand on such devices, which will be useful for surgical explorations and interventions. In this paper, we focus on a training and design simulator dedicated to such catheters. This simulator is based on an original simulation platform (OpenMASK. The catheter is a robotic system, which is evaluated by a dynamical simulation addressing a navigation task in its environment. The design of the prototype and its mechanical model are presented. We develop an interaction model for contact. This model uses a real medical database for which distance cartography is proposed. Then we focus on an autonomous control model based on a multi-agent approach and including the behaviour description of the SMA actuators. Results of mechanical simulations including interaction with the ducts are presented. Furthermore, the interest of such a simulator is presented by applying virtual prototyping techniques for the design optimization. This optimization process is achieved by using genetic algorithms at different stages with respect to the specified task.

  14. Modeling and simulation for process and safeguards system design

    International Nuclear Information System (INIS)

    Gutmacher, R.G.; Kern, E.A.; Duncan, D.R.; Benecke, M.W.

    1983-01-01

    A computer modeling and simulation approach that meets the needs of both the process and safeguards system designers is described. The results have been useful to Westinghouse Hanford Company process designers in optimizing the process scenario and operating scheme of the Secure Automated Fabrication line. The combined process/measurements model will serve as the basis for design of the safeguards system. Integration of the process design and the safeguards system design should result in a smoothly operating process that is easier to safeguard

  15. Design-Based Comparison of Spine Surgery Simulators: Optimizing Educational Features of Surgical Simulators.

    Science.gov (United States)

    Ryu, Won Hyung A; Mostafa, Ahmed E; Dharampal, Navjit; Sharlin, Ehud; Kopp, Gail; Jacobs, W Bradley; Hurlbert, R John; Chan, Sonny; Sutherland, Garnette R

    2017-10-01

    Simulation-based education has made its entry into surgical residency training, particularly as an adjunct to hands-on clinical experience. However, one of the ongoing challenges to wide adoption is the capacity of simulators to incorporate educational features required for effective learning. The aim of this study was to identify strengths and limitations of spine simulators to characterize design elements that are essential in enhancing resident education. We performed a mixed qualitative and quantitative cohort study with a focused survey and interviews of stakeholders in spine surgery pertaining to their experiences on 3 spine simulators. Ten participants were recruited spanning all levels of training and expertise until qualitative analysis reached saturation of themes. Participants were asked to perform lumbar pedicle screw insertion on 3 simulators. Afterward, a 10-item survey was administrated and a focused interview was conducted to explore topics pertaining to the design features of the simulators. Overall impressions of the simulators were positive with regards to their educational benefit, but our qualitative analysis revealed differing strengths and limitations. Main design strengths of the computer-based simulators were incorporation of procedural guidance and provision of performance feedback. The synthetic model excelled in achieving more realistic haptic feedback and incorporating use of actual surgical tools. Stakeholders from trainees to experts acknowledge the growing role of simulation-based education in spine surgery. However, different simulation modalities have varying design elements that augment learning in distinct ways. Characterization of these design characteristics will allow for standardization of simulation curricula in spinal surgery, optimizing educational benefit. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. Renal Artery Stenosis (RAS) Case study

    International Nuclear Information System (INIS)

    Zaater, M.K.

    2012-01-01

    Renal Artery Stenosis (RAS), is one of the causes of secondary hypertension; there are many causes of renal artery stenosis, as atherosclerosis of the renal artery which account for 90% of cases of RAS; fibromuscular dysplasia accounts for 10% of RAS. Various causes of thrombophilia either due congenital causes or acquired causes and can lead to RAS. Our patient was presented by acute attack of epistaxis and hypertension. Angiography of the Renal Arteries,are showed no sign of renal artery stenosis. However, the right kidney showed upper pole infarction, and the left kidney showed evidence of functional lower pole renal artery stenosis, although there is no anatomical stenosis detected in angiography. Work up for the cause of thrombophilia did not help in the diagnosis, which may be due to an undiscovered cause of thrombophilia

  17. Design and Simulation of MEMS Devices using Interval Analysis

    International Nuclear Information System (INIS)

    Shanmugavalli, M; Uma, G; Vasuki, B; Umapathy, M

    2006-01-01

    Modeling and simulation of MEMS devices are used to optimize the design, to improve the performance of the device, to reduce time to market, to minimize development time and cost by avoiding unnecessary design cycles and foundry runs. The major design objectives in any device design, is to meet the required functional parameters and the reliability of the device. The functional parameters depend on the geometry of the structure, material properties and process parameters. All model parameters act as input to optimize the functional parameters. The major difficulty the designer faces is the dimensions and properties used in the simulation of the MEMS devices can not be exactly followed during fabrication. In order to overcome this problem, the designer must test the device in simulation for bound of parameters involved in it. The paper demonstrates the use of interval methods to assess the electromechanical behaviour of micro electromechanical systems (MEMS) under the presence of manufacturing and process uncertainties. Interval method guides the design of pullin voltage analysis of fixed-fixed beam to achieve a robust and reliable design in a most efficient way. The methods are implemented numerically using Coventorware and analytically using Intlab

  18. Logic hybrid simulation-optimization algorithm for distillation design

    OpenAIRE

    Caballero Suárez, José Antonio

    2014-01-01

    In this paper, we propose a novel algorithm for the rigorous design of distillation columns that integrates a process simulator in a generalized disjunctive programming formulation. The optimal distillation column, or column sequence, is obtained by selecting, for each column section, among a set of column sections with different number of theoretical trays. The selection of thermodynamic models, properties estimation etc., are all in the simulation environment. All the numerical issues relat...

  19. Simulation system architecture design for generic communications link

    Science.gov (United States)

    Tsang, Chit-Sang; Ratliff, Jim

    1986-01-01

    This paper addresses a computer simulation system architecture design for generic digital communications systems. It addresses the issues of an overall system architecture in order to achieve a user-friendly, efficient, and yet easily implementable simulation system. The system block diagram and its individual functional components are described in detail. Software implementation is discussed with the VAX/VMS operating system used as a target environment.

  20. Adding Value in Construction Design Management by Using Simulation Approach

    OpenAIRE

    Doloi, Hemanta

    2008-01-01

    Simulation modelling has been introduced as a decision support tool for front end planning and design analysis of projects. An integrated approach has been discussed linking project scope, end product or project facility performance and the strategic project objectives at the early stage of projects. The case study example on tram network demonstrates that application of simulation helps assessing performance of project operation and making appropriate investment decisions over life cycle of ...

  1. The higher level of complexity of K-Ras4B activation at the membrane

    Science.gov (United States)

    Jang, Hyunbum; Banerjee, Avik; Chavan, Tanmay S.; Lu, Shaoyong; Zhang, Jian; Gaponenko, Vadim; Nussinov, Ruth

    2016-01-01

    Is nucleotide exchange sufficient to activate K-Ras4B? To signal, oncogenic rat sarcoma (Ras) anchors in the membrane and recruits effectors by exposing its effector lobe. With the use of NMR and molecular dynamics (MD) simulations, we observed that in solution, farnesylated guanosine 5′-diphosphate (GDP)-bound K-Ras4B is predominantly autoinhibited by its hypervariable region (HVR), whereas the GTP-bound state favors an activated, HVR-released state. On the anionic membrane, the catalytic domain adopts multiple orientations, including parallel (∼180°) and perpendicular (∼90°) alignments of the allosteric helices, with respect to the membrane surface direction. In the autoinhibited state, the HVR is sandwiched between the effector lobe and the membrane; in the active state, with membrane-anchored farnesyl and unrestrained HVR, the catalytic domain fluctuates reinlessly, exposing its effector-binding site. Dimerization and clustering can reduce the fluctuations. This achieves preorganized, productive conformations. Notably, we also observe HVR-autoinhibited K-Ras4B-GTP states, with GDP-bound-like orientations of the helices. Thus, we propose that the GDP/GTP exchange may not be sufficient for activation; instead, our results suggest that the GDP/GTP exchange, HVR sequestration, farnesyl insertion, and orientation/localization of the catalytic domain at the membrane conjointly determine the active or inactive state of K-Ras4B. Importantly, K-Ras4B-GTP can exist in active and inactive states; on its own, GTP binding may not compel K-Ras4B activation.—Jang, H., Banerjee, A., Chavan, T. S, Lu, S., Zhang, J., Gaponenko, V., Nussinov, R. The higher level of complexity of K-Ras4B activation at the membrane. PMID:26718888

  2. The higher level of complexity of K-Ras4B activation at the membrane.

    Science.gov (United States)

    Jang, Hyunbum; Banerjee, Avik; Chavan, Tanmay S; Lu, Shaoyong; Zhang, Jian; Gaponenko, Vadim; Nussinov, Ruth

    2016-04-01

    Is nucleotide exchange sufficient to activate K-Ras4B? To signal, oncogenic rat sarcoma (Ras) anchors in the membrane and recruits effectors by exposing its effector lobe. With the use of NMR and molecular dynamics (MD) simulations, we observed that in solution, farnesylated guanosine 5'-diphosphate (GDP)-bound K-Ras4B is predominantly autoinhibited by its hypervariable region (HVR), whereas the GTP-bound state favors an activated, HVR-released state. On the anionic membrane, the catalytic domain adopts multiple orientations, including parallel (∼180°) and perpendicular (∼90°) alignments of the allosteric helices, with respect to the membrane surface direction. In the autoinhibited state, the HVR is sandwiched between the effector lobe and the membrane; in the active state, with membrane-anchored farnesyl and unrestrained HVR, the catalytic domain fluctuates reinlessly, exposing its effector-binding site. Dimerization and clustering can reduce the fluctuations. This achieves preorganized, productive conformations. Notably, we also observe HVR-autoinhibited K-Ras4B-GTP states, with GDP-bound-like orientations of the helices. Thus, we propose that the GDP/GTP exchange may not be sufficient for activation; instead, our results suggest that the GDP/GTP exchange, HVR sequestration, farnesyl insertion, and orientation/localization of the catalytic domain at the membrane conjointly determine the active or inactive state of K-Ras4B. Importantly, K-Ras4B-GTP can exist in active and inactive states; on its own, GTP binding may not compel K-Ras4B activation.-Jang, H., Banerjee, A., Chavan, T. S, Lu, S., Zhang, J., Gaponenko, V., Nussinov, R. The higher level of complexity of K-Ras4B activation at the membrane. © FASEB.

  3. Nuclear power plant C and I design verification by simulation

    International Nuclear Information System (INIS)

    Storm, Joachim; Yu, Kim; Lee, D.Y

    2003-01-01

    An important part of the Advanced Boiling Water Reactor (ABWR) in the Taiwan NPP Lungmen Units no.1 and no.2 is the Full Scope Simulator (FSS). The simulator was to be built according to design data and therefore, apart from the training aspect, a major part of the development is to apply a simulation based test bed for the verification, validation and improvement of plant design in the control and instrumentation (C and I) areas of unit control room equipment, operator Man Machine Interface (MMI), process computer functions and plant procedures. Furthermore the Full Scope Simulator will be used after that to allow proper training of the plant operators two years before Unit no.1 fuel load. The article describes scope, methods and results of the advanced verification and validation process and highlights the advantages of test bed simulation for real power plant design and implementation. Subsequent application of advanced simulation software tools like instrumentation and control translators, graphical model builders, process models, graphical on-line test tools and screen based or projected soft panels, allowed a team to fulfil the task of C and I verification in time before the implementation of the Distributed Control and Information System (DCIS) started. An additional area of activity was the Human Factors Engineering (HFE) for the operator MMI. Due to the fact that the ABWR design incorporates a display-based operation with most of the plant components, a dedicated verification and validation process is required by NUREG-0711. In order to support this activity an engineering test system had been installed for all the necessary HFE investigations. All detected improvements had been properly documented and used to update the plant design documentation by a defined process. The Full Scope Simulator (FSS) with hard panels and stimulated digital control and information system are in the final acceptance test process with the end customer, Taiwan Power Company

  4. An overview of the design and analysis of simulation experiments for sensitivity analysis

    NARCIS (Netherlands)

    Kleijnen, J.P.C.

    2005-01-01

    Sensitivity analysis may serve validation, optimization, and risk analysis of simulation models. This review surveys 'classic' and 'modern' designs for experiments with simulation models. Classic designs were developed for real, non-simulated systems in agriculture, engineering, etc. These designs

  5. Monte Carlo simulations for design of the KFUPM PGNAA facility

    CERN Document Server

    Naqvi, A A; Maslehuddin, M; Kidwai, S

    2003-01-01

    Monte Carlo simulations were carried out to design a 2.8 MeV neutron-based prompt gamma ray neutron activation analysis (PGNAA) setup for elemental analysis of cement samples. The elemental analysis was carried out using prompt gamma rays produced through capture of thermal neutrons in sample nuclei. The basic design of the PGNAA setup consists of a cylindrical cement sample enclosed in a cylindrical high-density polyethylene moderator placed between a neutron source and a gamma ray detector. In these simulations the predominant geometrical parameters of the PGNAA setup were optimized, including moderator size, sample size and shielding of the detector. Using the results of the simulations, an experimental PGNAA setup was then fabricated at the 350 kV Accelerator Laboratory of this University. The design calculations were checked experimentally through thermal neutron flux measurements inside the PGNAA moderator. A test prompt gamma ray spectrum of the PGNAA setup was also acquired from a Portland cement samp...

  6. LEGO - A Class Library for Accelerator Design and Simulation

    International Nuclear Information System (INIS)

    Cai, Yunhai

    1998-01-01

    An object-oriented class library of accelerator design and simulation is designed and implemented in a simple and modular fashion. All physics of single-particle dynamics is implemented based on the Hamiltonian in the local frame of the component. Symplectic integrators are used to approximate the integration of the Hamiltonian. A differential algebra class is introduced to extract a Taylor map up to arbitrary order. Analysis of optics is done in the same way both for the linear and non-linear cases. Recently, Monte Carlo simulation of synchrotron radiation has been added into the library. The code is used to design and simulate the lattices of the PEP-II and SPEAR3. And it is also used for the commissioning of the PEP-II. Some examples of how to use the library will be given

  7. Cyclic AMP signalling in Dictyostelium : G-proteins activate separate Ras pathways using specific RasGEFs

    NARCIS (Netherlands)

    Kae, Helmut; Kortholt, Arjan; Rehmann, Holger; Insall, RobertH.; Van Haastert, Peter J. M.; Spiegelman, George B.; Weeks, Gerald

    In general, mammalian Ras guanine nucleotide exchange factors (RasGEFs) show little substrate specificity, although they are often thought to regulate specific pathways. Here, we provide in vitro and in vivo evidence that two RasGEFs can each act on specific Ras proteins. During Dictyostelium

  8. Multimedia Terminal System-on-Chip Design and Simulation

    Directory of Open Access Journals (Sweden)

    Barbieri Ivano

    2005-01-01

    Full Text Available This paper proposes a design approach based on integrated architectural and system-on-chip (SoC simulations. The main idea is to have an efficient framework for the design and the evaluation of multimedia terminals, allowing a fast system simulation with a definable degree of accuracy. The design approach includes the simulation of very long instruction word (VLIW digital signal processors (DSPs, the utilization of a device multiplexing the media streams, and the emulation of the real-time media acquisition. This methodology allows the evaluation of both the multimedia algorithm implementations and the hardware platform, giving feedback on the complete SoC including the interaction between modules and conflicts in accessing either the bus or shared resources. An instruction set architecture (ISA simulator and an SoC simulation environment compose the integrated framework. In order to validate this approach, the evaluation of an audio-video multiprocessor terminal is presented, and the complete simulation test results are reported.

  9. Exploiting the bad eating habits of Ras-driven cancers.

    Science.gov (United States)

    White, Eileen

    2013-10-01

    Oncogenic Ras promotes glucose fermentation and glutamine use to supply central carbon metabolism, but how and why have only emerged recently. Ras-mediated metabolic reprogramming generates building blocks for growth and promotes antioxidant defense. To fuel metabolic pathways, Ras scavenges extracellular proteins and lipids. To bolster metabolism and mitigate stress, Ras activates cellular self-cannibalization and recycling of proteins and organelles by autophagy. Targeting these distinct features of Ras-driven cancers provides novel approaches to cancer therapy.

  10. Inhibition of RAS in diabetic nephropathy

    Directory of Open Access Journals (Sweden)

    Yacoub R

    2015-04-01

    Full Text Available Rabi Yacoub, Kirk N Campbell Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY, USA Abstract: Diabetic kidney disease (DKD is a progressive proteinuric renal disorder in patients with type 1 or type 2 diabetes mellitus. It is a common cause of end-stage kidney disease worldwide, particularly in developed countries. Therapeutic targeting of the renin–angiotensin system (RAS is the most validated clinical strategy for slowing disease progression. DKD is paradoxically a low systematic renin state with an increased intrarenal RAS activity implicated in its pathogenesis. Angiotensin II (AngII, the main peptide of RAS, is not only a vasoactive peptide but functions as a growth factor, activating interstitial fibroblasts and mesangial and tubular cells, while promoting the synthesis of extracellular matrix proteins. AngII also promotes podocyte injury through increased calcium influx and the generation of reactive oxygen species. Blockade of the RAS using either angiotensin converting enzyme inhibitors, or angiotensin receptor blockers can attenuate progressive glomerulosclerosis in animal models, and slows disease progression in humans with DKD. In this review, we summarize the role of intrarenal RAS activation in the pathogenesis and progression of DKD and the rationale for RAS inhibition in this population. Keywords: renin–angiotensin system, diabetic kidney disease, angiotensin II, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers

  11. Simulation of the Compact Ignition Tokamak (CIT) conceptual design

    International Nuclear Information System (INIS)

    Carlson, K.E.; Wareing, T.L.

    1988-01-01

    Calculations have been made using the Advanced Thermal Hydraulic Energy Network Analysis (ATHENA) code that simulate the cool down of the cryostat and the performance of the condensing heat exchanger. The purpose of this simulation was to confirm the estimated 30 minute cool down time and to size a condensing heat exchanger for the CIT liquid nitrogen cooling system. This report includes a brief description of the ATHENA code, descriptions of proposed CIT cryostat and condenser designs, and the associated ATHENA models representing these design. This is followed by the ATHENA calculated results and conclusions concerning the results. 6 refs., 17 figs

  12. Introduction to RF power amplifier design and simulation

    CERN Document Server

    Eroglu, Abdullah

    2015-01-01

    Introduction to RF Power Amplifier Design and Simulation fills a gap in the existing literature by providing step-by-step guidance for the design of radio frequency (RF) power amplifiers, from analytical formulation to simulation, implementation, and measurement. Featuring numerous illustrations and examples of real-world engineering applications, this book:Gives an overview of intermodulation and elaborates on the difference between linear and nonlinear amplifiersDescribes the high-frequency model and transient characteristics of metal-oxide-semiconductor field-effect transistorsDetails activ

  13. Simulated annealing algorithm for reactor in-core design optimizations

    International Nuclear Information System (INIS)

    Zhong Wenfa; Zhou Quan; Zhong Zhaopeng

    2001-01-01

    A nuclear reactor must be optimized for in core fuel management to make full use of the fuel, to reduce the operation cost and to flatten the power distribution reasonably. The author presents a simulated annealing algorithm. The optimized objective function and the punishment function were provided for optimizing the reactor physics design. The punishment function was used to practice the simulated annealing algorithm. The practical design of the NHR-200 was calculated. The results show that the K eff can be increased by 2.5% and the power distribution can be flattened

  14. A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors.

    Science.gov (United States)

    Loboda, Andrey; Nebozhyn, Michael; Klinghoffer, Rich; Frazier, Jason; Chastain, Michael; Arthur, William; Roberts, Brian; Zhang, Theresa; Chenard, Melissa; Haines, Brian; Andersen, Jannik; Nagashima, Kumiko; Paweletz, Cloud; Lynch, Bethany; Feldman, Igor; Dai, Hongyue; Huang, Pearl; Watters, James

    2010-06-30

    Hyperactivation of the Ras signaling pathway is a driver of many cancers, and RAS pathway activation can predict response to targeted therapies. Therefore, optimal methods for measuring Ras pathway activation are critical. The main focus of our work was to develop a gene expression signature that is predictive of RAS pathway dependence. We used the coherent expression of RAS pathway-related genes across multiple datasets to derive a RAS pathway gene expression signature and generate RAS pathway activation scores in pre-clinical cancer models and human tumors. We then related this signature to KRAS mutation status and drug response data in pre-clinical and clinical datasets. The RAS signature score is predictive of KRAS mutation status in lung tumors and cell lines with high (> 90%) sensitivity but relatively low (50%) specificity due to samples that have apparent RAS pathway activation in the absence of a KRAS mutation. In lung and breast cancer cell line panels, the RAS pathway signature score correlates with pMEK and pERK expression, and predicts resistance to AKT inhibition and sensitivity to MEK inhibition within both KRAS mutant and KRAS wild-type groups. The RAS pathway signature is upregulated in breast cancer cell lines that have acquired resistance to AKT inhibition, and is downregulated by inhibition of MEK. In lung cancer cell lines knockdown of KRAS using siRNA demonstrates that the RAS pathway signature is a better measure of dependence on RAS compared to KRAS mutation status. In human tumors, the RAS pathway signature is elevated in ER negative breast tumors and lung adenocarcinomas, and predicts resistance to cetuximab in metastatic colorectal cancer. These data demonstrate that the RAS pathway signature is superior to KRAS mutation status for the prediction of dependence on RAS signaling, can predict response to PI3K and RAS pathway inhibitors, and is likely to have the most clinical utility in lung and breast tumors.

  15. A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors

    Directory of Open Access Journals (Sweden)

    Paweletz Cloud

    2010-06-01

    Full Text Available Abstract Background Hyperactivation of the Ras signaling pathway is a driver of many cancers, and RAS pathway activation can predict response to targeted therapies. Therefore, optimal methods for measuring Ras pathway activation are critical. The main focus of our work was to develop a gene expression signature that is predictive of RAS pathway dependence. Methods We used the coherent expression of RAS pathway-related genes across multiple datasets to derive a RAS pathway gene expression signature and generate RAS pathway activation scores in pre-clinical cancer models and human tumors. We then related this signature to KRAS mutation status and drug response data in pre-clinical and clinical datasets. Results The RAS signature score is predictive of KRAS mutation status in lung tumors and cell lines with high (> 90% sensitivity but relatively low (50% specificity due to samples that have apparent RAS pathway activation in the absence of a KRAS mutation. In lung and breast cancer cell line panels, the RAS pathway signature score correlates with pMEK and pERK expression, and predicts resistance to AKT inhibition and sensitivity to MEK inhibition within both KRAS mutant and KRAS wild-type groups. The RAS pathway signature is upregulated in breast cancer cell lines that have acquired resistance to AKT inhibition, and is downregulated by inhibition of MEK. In lung cancer cell lines knockdown of KRAS using siRNA demonstrates that the RAS pathway signature is a better measure of dependence on RAS compared to KRAS mutation status. In human tumors, the RAS pathway signature is elevated in ER negative breast tumors and lung adenocarcinomas, and predicts resistance to cetuximab in metastatic colorectal cancer. Conclusions These data demonstrate that the RAS pathway signature is superior to KRAS mutation status for the prediction of dependence on RAS signaling, can predict response to PI3K and RAS pathway inhibitors, and is likely to have the most clinical

  16. New tools for the simulation and design of calorimeters

    International Nuclear Information System (INIS)

    Womersley, W.J.

    1989-01-01

    Two new approaches to the simulation and design of large hermetic calorimeters are presented. Firstly, the Shower Library scheme used in the fast generation of showers in the Monte Carlo of the calorimeter for the D-Zero experiment at the Fermilab Tevatron is described. Secondly, a tool for the design future calorimeters is described, which can be integrated with a computer aided design system to give engineering designers an immediate idea of the relative physics capabilities of different geometries. 9 refs., 6 figs., 1 tab

  17. Optimization of a neutron detector design using adjoint transport simulation

    International Nuclear Information System (INIS)

    Yi, C.; Manalo, K.; Huang, M.; Chin, M.; Edgar, C.; Applegate, S.; Sjoden, G.

    2012-01-01

    A synthetic aperture approach has been developed and investigated for Special Nuclear Materials (SNM) detection in vehicles passing a checkpoint at highway speeds. SNM is postulated to be stored in a moving vehicle and detector assemblies are placed on the road-side or in chambers embedded below the road surface. Neutron and gamma spectral awareness is important for the detector assembly design besides high efficiencies, so that different SNMs can be detected and identified with various possible shielding settings. The detector assembly design is composed of a CsI gamma-ray detector block and five neutron detector blocks, with peak efficiencies targeting different energy ranges determined by adjoint simulations. In this study, formulations are derived using adjoint transport simulations to estimate detector efficiencies. The formulations is applied to investigate several neutron detector designs for Block IV, which has its peak efficiency in the thermal range, and Block V, designed to maximize the total neutron counts over the entire energy spectrum. Other Blocks detect different neutron energies. All five neutron detector blocks and the gamma-ray block are assembled in both MCNP and deterministic simulation models, with detector responses calculated to validate the fully assembled design using a 30-group library. The simulation results show that the 30-group library, collapsed from an 80-group library using an adjoint-weighting approach with the YGROUP code, significantly reduced the computational cost while maintaining accuracy. (authors)

  18. Software Design for Interactive Graphic Radiation Treatment Simulation Systems*

    Science.gov (United States)

    Kalet, Ira J.; Sweeney, Christine; Jacky, Jonathan

    1990-01-01

    We examine issues in the design of interactive computer graphic simulation programs for radiation treatment planning (RTP), as well as expert system programs that automate parts of the RTP process, in light of ten years of experience at designing, building and using such programs. An experiment in object-oriented design using standard Pascal shows that while some advantage is gained from the design, it is still difficult to achieve modularity and to integrate expert system components. A new design based on the Common LISP Object System (CLOS) is described. This series of designs for RTP software shows that this application benefits in specific ways from object-oriented design methods and appropriate languages and tools.

  19. Design principles for simulation games for learning clinical reasoning: A design-based research approach.

    Science.gov (United States)

    Koivisto, J-M; Haavisto, E; Niemi, H; Haho, P; Nylund, S; Multisilta, J

    2018-01-01

    Nurses sometimes lack the competence needed for recognising deterioration in patient conditions and this is often due to poor clinical reasoning. There is a need to develop new possibilities for learning this crucial competence area. In addition, educators need to be future oriented; they need to be able to design and adopt new pedagogical innovations. The purpose of the study is to describe the development process and to generate principles for the design of nursing simulation games. A design-based research methodology is applied in this study. Iterative cycles of analysis, design, development, testing and refinement were conducted via collaboration among researchers, educators, students, and game designers. The study facilitated the generation of reusable design principles for simulation games to guide future designers when designing and developing simulation games for learning clinical reasoning. This study makes a major contribution to research on simulation game development in the field of nursing education. The results of this study provide important insights into the significance of involving nurse educators in the design and development process of educational simulation games for the purpose of nursing education. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. INTELLIGENT DESIGN: ON THE EMULATION OF COSMOLOGICAL SIMULATIONS

    International Nuclear Information System (INIS)

    Schneider, Michael D.; Holm, Oskar; Knox, Lloyd

    2011-01-01

    Simulation design is the choice of locations in parameter space at which simulations are to be run and is the first step in building an emulator capable of quickly providing estimates of simulation results for arbitrary locations in the parameter space. We introduce an alteration to the 'OALHS' design used by Heitmann et al. that reduces the number of simulation runs required to achieve a fixed accuracy in our case study by a factor of two. We also compare interpolation procedures for emulators and find that interpolation via Gaussian process models and via the much-easier-to-implement polynomial interpolation have comparable accuracy. A very simple emulation-building procedure consisting of a design sampled from the parameter prior distribution, combined with interpolation via polynomials also performs well. Although our primary motivation is efficient emulators of nonlinear cosmological N-body simulations, in an appendix we describe an emulator for the cosmic microwave background temperature power spectrum publicly available as a computer code.

  1. Oxidative Stress Posttranslationally Regulates the Expression of Ha-Ras and Ki-Ras in Cultured Astrocytes

    Directory of Open Access Journals (Sweden)

    Samantha Messina

    2012-01-01

    Full Text Available Addition of hydrogen peroxide to cultured astrocytes induced a rapid and transient increase in the expression of Ha-Ras and Ki-Ras. Pull-down experiments with the GTP-Ras-binding domain of Raf-1 showed that oxidative stress substantially increased the activation of Ha-Ras, whereas a putative farnesylated activated form of Ki-Ras was only slightly increased. The increase in both Ha-Ras and Ki-Ras was insensitive to the protein synthesis inhibitor, cycloheximide, and was occluded by the proteasomal inhibitor, MG-132. In addition, exposure to hydrogen peroxide reduced the levels of ubiquitinated Ras protein, indicating that oxidative stress leads to a reduced degradation of both isoforms through the ubiquitin/proteasome pathway. Indeed, the late reduction in Ha-Ras and Ki-Ras was due to a recovery of proteasomal degradation because it was sensitive to MG-132. The late reduction of Ha-Ras levels was abrogated by compound PD98059, which inhibits the MAP kinase pathway, whereas the late reduction of Ki-Ras was unaffected by PD98059. We conclude that oxidative stress differentially regulates the expression of Ha-Ras and Ki-Ras in cultured astrocytes, and that activation of the MAP kinase pathway by oxidative stress itself or by additional factors may act as a fail-safe mechanism limiting a sustained expression of the potentially detrimental Ha-Ras.

  2. User Interface Design to Bring Simulation Data into the Classroom

    International Nuclear Information System (INIS)

    Tebbe, P.A.

    1999-01-01

    The training and simulation staff at the AmerenUE Callaway nuclear plant has been given the task of implementing the plant full-scope simulator in a classroom setting. As part of this project, members of the Nuclear Engineering Program at the University of Missouri, Columbia are working with plant personnel to create desktop software for use in training on fundamental plant principles. Data are created with the same modeling software used to power the simulator and are made available with the existing dynamic database structure. Visualization is provided through a specially designed user interface, created with the G programming language of LabVIEW. It is hoped that by focusing on a specific topic and designing the interface with educational objectives in mind, this software will help provide operators with an improved understanding of fundamental principles

  3. Software for simulation and design of neutron scattering instrumentation

    DEFF Research Database (Denmark)

    Bertelsen, Mads

    designed using the software. The Union components uses a new approach to simulation of samples in McStas. The properties of a sample are split into geometrical and material, simplifying user input, and allowing the construction of complicated geometries such as sample environments. Multiple scattering...... from conventional choices. Simulation of neutron scattering instrumentation is used when designing instrumentation, but also to understand instrumental effects on the measured scattering data. The Monte Carlo ray-tracing package McStas is among the most popular, capable of simulating the path of each...... neutron through the instrument using an easy to learn language. The subject of the defended thesis is contributions to the McStas language in the form of the software package guide_bot and the Union components.The guide_bot package simplifies the process of optimizing neutron guides by writing the Mc...

  4. Simulink and CATIA for Modelling, Simulation and Design

    DEFF Research Database (Denmark)

    Conrad, Finn

    2005-01-01

    The paper presents a proposed IT-Tools concept for modelling, simulation, analysis and design of water hydraulic actuators for motion control of machines, lifts, cranes and robots. Matlab/Simulink and CATIA are used as IT-Tools. The contributions include results from on-going research projects...

  5. Design and simulation of 120 capacity automobile parking control ...

    African Journals Online (AJOL)

    Design and simulation of 120 capacity automobile parking control system using up/down decade counters. ... leave(s) the parking lot through the exit gate the counter counts down, and the DC motor circuitry drives the entry gate open to allow access for the same number of automobiles that leave(s) the parking lot.

  6. Designing in situ simulation in the emergency department

    DEFF Research Database (Denmark)

    Paltved, Charlotte; Bjerregaard, Anders Thais; Krogh, Kristian

    2017-01-01

    Baggrund: Dette interventionsstudie har til formål at forbedre patientsikkerheden gennem design af in situ simulation. Undersøgelsen fandt sted på en akut medicinsk stue i den centrale region i Danmark. Forskning tyder på, at mangelfuld handover kommunikation kan øge sandsynligheden for kritiske ...

  7. Design gaze simulation for people with visual disability

    NARCIS (Netherlands)

    Qiu, S.

    2017-01-01

    In face-to-face communication, eye gaze is integral to a conversation to supplement verbal language. The sighted often uses eye gaze to convey nonverbal information in social interactions, which a blind conversation partner cannot access and react. My doctoral research is to design gaze simulation

  8. Two-dimensional integrated Z-pinch ICF design simulations

    Energy Technology Data Exchange (ETDEWEB)

    Lash, J.S.

    1999-07-01

    The dynamic hohlraum ICF concept for a Z-pinch driver utilizes the imploding wire array collision with a target to produce a radiation history suitable for driving an embedded inertial confinement fusion (ICF) capsule. This target may consist of various shaped layers of low-density foams or solid-density materials. The use of detailed radiation magneto-hydrodynamic (RMHD) modeling is required for understanding and designing these complex systems. Critical to producing credible simulations and designs is inclusion of the Rayleigh-Taylor unstable wire-array dynamics; the bubble and spike structure of the collapsing sheath may yield regions of low-opacity enhancing radiation loss as well as introduce non-uniformities in the capsule's radiation drive. Recent improvements in LASNEX have allowed significant progress to be made in the modeling of unstable z-pinch implosions. Combining this with the proven ICF capsule design capabilities of LASNEX, the authors now have the modeling tools to produce credible, fully-integrated ICF dynamic hohlraum simulations. They present detailed two-dimensional RMHD simulations of recent ICF dynamic hohlraum experiments on the Sandia Z-machine as well as design simulations for the next-generation Z-pinch facility and future high-yield facility.

  9. Two-dimensional integrated Z-pinch ICF design simulations

    International Nuclear Information System (INIS)

    Lash, J.S.

    1999-01-01

    The dynamic hohlraum ICF concept for a Z-pinch driver utilizes the imploding wire array collision with a target to produce a radiation history suitable for driving an embedded inertial confinement fusion (ICF) capsule. This target may consist of various shaped layers of low-density foams or solid-density materials. The use of detailed radiation magneto-hydrodynamic (RMHD) modeling is required for understanding and designing these complex systems. Critical to producing credible simulations and designs is inclusion of the Rayleigh-Taylor unstable wire-array dynamics; the bubble and spike structure of the collapsing sheath may yield regions of low-opacity enhancing radiation loss as well as introduce non-uniformities in the capsule's radiation drive. Recent improvements in LASNEX have allowed significant progress to be made in the modeling of unstable z-pinch implosions. Combining this with the proven ICF capsule design capabilities of LASNEX, the authors now have the modeling tools to produce credible, fully-integrated ICF dynamic hohlraum simulations. They present detailed two-dimensional RMHD simulations of recent ICF dynamic hohlraum experiments on the Sandia Z-machine as well as design simulations for the next-generation Z-pinch facility and future high-yield facility

  10. FEM assisted design and simulation of novel electrothermal actuators

    NARCIS (Netherlands)

    Deladi, S.; Krijnen, Gijsbertus J.M.; Elwenspoek, Michael Curt

    2003-01-01

    In this work the authors present the design, simulation, and experimental results of novel electrothermal actuators, such as the trimorph actuator for out-of-plane motion, the coupled in-plane actuator for in-plane motion and an actuator providing combined in- and out-of-plane motion that have been

  11. FPGA Controller Design and Simulation of a Portable Dough Mixing ...

    African Journals Online (AJOL)

    With the advent of Microcontrollers, Application Specic Integrated Circuits, Digital Signal Processors (DSP) and Programmable Logic Devices, complex industrial systems and controls can now be integrated into portable embedded household electronic systems. In this paper, the design and simulation of a Dough Mixer ...

  12. Simulation Experiments in Practice : Statistical Design and Regression Analysis

    NARCIS (Netherlands)

    Kleijnen, J.P.C.

    2007-01-01

    In practice, simulation analysts often change only one factor at a time, and use graphical analysis of the resulting Input/Output (I/O) data. Statistical theory proves that more information is obtained when applying Design Of Experiments (DOE) and linear regression analysis. Unfortunately, classic

  13. Simulation Experiments in Practice : Statistical Design and Regression Analysis

    NARCIS (Netherlands)

    Kleijnen, J.P.C.

    2007-01-01

    In practice, simulation analysts often change only one factor at a time, and use graphical analysis of the resulting Input/Output (I/O) data. The goal of this article is to change these traditional, naïve methods of design and analysis, because statistical theory proves that more information is

  14. The design and implementation of a network simulation platform

    CSIR Research Space (South Africa)

    Von Solms, S

    2013-11-01

    Full Text Available these events and their effects can enable researchers to identify these threats and find ways to counter them. In this paper we present the design of a network simulation platform which can enable researchers to study dynamic behaviour of networks, network...

  15. Climate Responsive Design Simulation and Modelling for Industrial Heritage

    Directory of Open Access Journals (Sweden)

    Manuel V. Castilla

    2018-01-01

    Full Text Available The control of solar radiation is a basic dimension of modern design in all different types of constructions. Many architects have recently observed that different phases of sustainable design require a set of calculations and simulations that are necessary as a new standard design. The valuable contributions to the process of sustainable design has a common denominator: solar radiation and comfort. In this way, motivated by all these new strategies and concepts, the large number of papers published suggests that the work has not been finished. This work provides an illustration of the Atarazanas regarding its climate responsiveness, focusing specifically on daylighting, shading, heat gain, and cooling loads. The objective is to assess the design of the Reales Atarazanas de Sevilla (Seville Royal Dockyards to quantify how it is impacted by solar insolation and to provide insights about design characteristics that influence efficiency and conservation.

  16. Enhanced avatar design using cognitive map-based simulation.

    Science.gov (United States)

    Lee, Kun Chang; Moon, Byung Suk

    2007-12-01

    With the advent of the Internet era and the maturation of electronic commerce, strategic avatar design has become an important way of keeping up with market changes and customer tastes. In this study, we propose a new approach to an adaptive avatar design that uses cognitive map (CM) as a what-if simulation vehicle. The main virtue of the new design is its ability to change specific avatar design features with objective consideration of the subsequent effects upon other design features, thereby enhancing user satisfaction. Statistical analyses of focus group interview results with a group of experts majoring in avatars and CM showed that our proposed approach could be used to effectively analyze avatar design in an adaptive and practical manner when the market situation is changing.

  17. Design of Accelerator Online Simulator Server Using Structured Data

    International Nuclear Information System (INIS)

    Shen, Guobao

    2012-01-01

    Model based control plays an important role for a modern accelerator during beam commissioning, beam study, and even daily operation. With a realistic model, beam behaviour can be predicted and therefore effectively controlled. The approach used by most current high level application environments is to use a built-in simulation engine and feed a realistic model into that simulation engine. Instead of this traditional monolithic structure, a new approach using a client-server architecture is under development. An on-line simulator server is accessed via network accessible structured data. With this approach, a user can easily access multiple simulation codes. This paper describes the design, implementation, and current status of PVData, which defines the structured data, and PVAccess, which provides network access to the structured data.

  18. Software simulation: a tool for enhancing control system design

    International Nuclear Information System (INIS)

    Sze, B.; Ridgway, G.H.

    2008-01-01

    The creation, implementation and management of engineering design tools are important to the quality and efficiency of any large engineering project. Some of the most complicated tools to develop are system simulators. The development and implementation of system simulators to support replacement fuel handling control systems is of particular interest to the Canadian nuclear industry given the current age of installations and the risk of obsolescence to many utilities. The use of such simulator tools has been known to significantly improve successful deployment of new software packages and maintenance-related software changes while reducing the time required for their overall development. Moreover, these simulation systems can also serve as operator training stations and provide a virtual environment for site engineers to test operational changes before they are uploaded to the actual system. (author)

  19. Cosmic reionization on computers. I. Design and calibration of simulations

    Energy Technology Data Exchange (ETDEWEB)

    Gnedin, Nickolay Y., E-mail: gnedin@fnal.gov [Particle Astrophysics Center, Fermi National Accelerator Laboratory, Batavia, IL 60510 (United States)

    2014-09-20

    Cosmic Reionization On Computers is a long-term program of numerical simulations of cosmic reionization. Its goal is to model fully self-consistently (albeit not necessarily from the first principles) all relevant physics, from radiative transfer to gas dynamics and star formation, in simulation volumes of up to 100 comoving Mpc, and with spatial resolution approaching 100 pc in physical units. In this method paper, we describe our numerical method, the design of simulations, and the calibration of numerical parameters. Using several sets (ensembles) of simulations in 20 h {sup –1} Mpc and 40 h {sup –1} Mpc boxes with spatial resolution reaching 125 pc at z = 6, we are able to match the observed galaxy UV luminosity functions at all redshifts between 6 and 10, as well as obtain reasonable agreement with the observational measurements of the Gunn-Peterson optical depth at z < 6.

  20. Study, simulation and design of a 3D clinostat

    Science.gov (United States)

    Pavone, Valentina; Guarnieri, Vincenzo; Lobascio, Cesare; Soma, Aurelio; Bosso, Nicola; Lamantea, Matteo Maria

    High cost and limited number of physically executable experiments in space have introduced the need for ground simulation systems that enable preparing experiments to be carried out on board, identifying phenomena associated with the altered gravity conditions, and taking advantage of these conditions, as in Biotechnology. Among systems developed to simulate microgravity, especially for life sciences experiments, different types of clinostats were realized. This work deals with mechanical design of a three-dimensional clinostat and simulation of the dynamic behavior of the system by varying the operating parameters. The design and simulation phase was preceded by a careful analysis of the state of art and by the review of the most recent results, in particular from the major investigators of Life Sciences in Space. The mechanical design is quite innovative by adoption of a structure entirely in aluminum, which allows robustness while reducing the overall weight. The transmission system of motion has been optimized by means of brushless DC micro motors, light and compact, which helped to reduce weight, dimensions, power consumption and increase the reliability and durability of the system. The study of the dynamic behavior using SIMPACK, a multibody simulation software, led to results in line with those found in the most important and recent scientific publications. This model was also appropriately configured to represent any desired operating condition, and for eventual system scalability. It would be interesting to generate simulated hypogravity - e.g.: 0.38-g (Mars) or 0.17-g (Moon). This would allow to investigate how terrestrial life forms can grow in other planetary habitats, or to determine the gravity threshold response of different organisms. At the moment, such a system can only be achieved by centrifuges in real microgravity. We are confident that simulation and associated tests with our 3D clinostat can help adjusting the parameters allowing variable g

  1. Eficacia de la terapia génica antisentido utilizando oligonucleótidos anti K-ras y antitelomerasa en cáncer colorrectal

    OpenAIRE

    Lledó, S.; Alfonso, R.; Aliño, S. F.

    2005-01-01

    Aim: to test the efficacy of anti-k-ras and antitelomerase oligonucleotides for disabling colorectal cancer cell growth. Material and methods: an established human colorectal cancer cell line (SW 480, ATTC®) was used. Oligodeoxiribonucleotides (ODNs) have a phosphorotioate modification to ensure intracellular intake. We used an antitelomerase ODN (Telp5) and two anti-k-ras ODNs (AS-KRAS and ISIS). AS-KRAS is designed to join the k-ras oncogene's exon 1. ISIS links to the terminal transcriptio...

  2. Simulation platform to model, optimize and design wind turbines

    Energy Technology Data Exchange (ETDEWEB)

    Iov, F.; Hansen, A.D.; Soerensen, P.; Blaabjerg, F.

    2004-03-01

    This report is a general overview of the results obtained in the project 'Electrical Design and Control. Simulation Platform to Model, Optimize and Design Wind Turbines'. The motivation for this research project is the ever-increasing wind energy penetration into the power network. Therefore, the project has the main goal to create a model database in different simulation tools for a system optimization of the wind turbine systems. Using this model database a simultaneous optimization of the aerodynamic, mechanical, electrical and control systems over the whole range of wind speeds and grid characteristics can be achieved. The report is structured in six chapters. First, the background of this project and the main goals as well as the structure of the simulation platform is given. The main topologies for wind turbines, which have been taken into account during the project, are briefly presented. Then, the considered simulation tools namely: HAWC, DIgSILENT, Saber and Matlab/Simulink have been used in this simulation platform are described. The focus here is on the modelling and simulation time scale aspects. The abilities of these tools are complementary and they can together cover all the modelling aspects of the wind turbines e.g. mechanical loads, power quality, switching, control and grid faults. However, other simulation packages e.g PSCAD/EMTDC can easily be added in the simulation platform. New models and new control algorithms for wind turbine systems have been developed and tested in these tools. All these models are collected in dedicated libraries in Matlab/Simulink as well as in Saber. Some simulation results from the considered tools are presented for MW wind turbines. These simulation results focuses on fixed-speed and variable speed/pitch wind turbines. A good agreement with the real behaviour of these systems is obtained for each simulation tool. These models can easily be extended to model different kinds of wind turbines or large wind

  3. PORFLOW Simulations Supporting Saltstone Disposal Unit Design Optimization

    Energy Technology Data Exchange (ETDEWEB)

    Flach, G. P. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Hang, T. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Taylor, G. A. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-12-10

    SRNL was requested by SRR to perform PORFLOW simulations to support potential cost-saving design modifications to future Saltstone Disposal Units in Z-Area (SRR-CWDA-2015-00120). The design sensitivity cases are defined in a modeling input specification document SRR-CWDA-2015-00133 Rev. 1. A high-level description of PORFLOW modeling and interpretation of results are provided in SRR-CWDA-2015-00169. The present report focuses on underlying technical issues and details of PORFLOW modeling not addressed by the input specification and results interpretation documents. Design checking of PORFLOW modeling is documented in SRNL-L3200-2015-00146.

  4. Design of Experiment Using Simulation of a Discrete Dynamical System

    Directory of Open Access Journals (Sweden)

    Mašek Jan

    2016-12-01

    Full Text Available The topic of the presented paper is a promising approach to achieve optimal Design of Experiment (DoE, i.e. spreading of points within a design domain, using a simulation of a discrete dynamical system of interacting particles within an n-dimensional design space. The system of mutually repelling particles represents a physical analogy of the Audze-Eglājs (AE optimization criterion and its periodical modification (PAE, respectively. The paper compares the performance of two approaches to implementation: a single-thread process using the JAVA language environment and a massively parallel solution employing the nVidia CUDA platform.

  5. RS-485 Bus Design of a Missile Simulation Training System

    Directory of Open Access Journals (Sweden)

    Liu Fang

    2013-07-01

    Full Text Available In a missile simulation training system with one-master and multi-slaves distributed system structure, a universal controller is necessary due to the system composed with several controllers. In this research, the designed controllers communicate with each other and upper control computer through RS-485 field bus. RS-485 bus including interface circuits, transmission protocol, Cyclic Redundancy Check (CRC method and upper control test software is designed and proposed. The universal controller adopting the designed RS-485 interface circuits is connected through twisted-pair and makes the simulation system, then the controller is tested in line. The results show that the RS-485 bus communicates effectively using the protocol and CRC method, data transmission rates reaches 115.2 kbps, and has a good stability.

  6. Modeling, simulation, and design of SAW grating filters

    Science.gov (United States)

    Schwelb, Otto; Adler, E. L.; Slaboszewicz, J. K.

    1990-05-01

    A systematic procedure for modeling, simulating, and designing SAW (surface acoustic wave) grating filters, taking losses into account, is described. Grating structures and IDTs (interdigital transducers) coupling to SAWs are defined by cascadable transmission-matrix building blocks. Driving point and transfer characteristics (immittances) of complex architectures consisting of gratings, transducers, and coupling networks are obtained by chain-multiplying building-block matrices. This modular approach to resonator filter analysis and design combines the elements of lossy filter synthesis with the transmission-matrix description of SAW components. A multipole filter design procedure based on a lumped-element-model approximation of one-pole two-port resonator building blocks is given and the range of validity of this model examined. The software for simulating the performance of SAW grating devices based on this matrix approach is described, and its performance, when linked to the design procedure to form a CAD/CAA (computer-aided design and analysis) multiple-filter design package, is illustrated with a resonator filter design example.

  7. Elektrisk Design og Styring. Simulation Platform to Model, Optimize and Design Wind Turbines

    DEFF Research Database (Denmark)

    Iov, Florin; Hansen, A. D.; Soerensen, P.

    This report is a general overview of the results obtained in the project ?Electrical Design and Control. Simulation Platform to Model, Optimize and Design Wind Turbines?. The report is structured in six chapters. First, the background of this project and the main goals as well as the structure...... of the simulation platform is given. The main topologies for wind turbines, which have been taken into account during the project, are briefly presented. Then, the considered simulation tools namely: HAWC, DIgSILENT, Saber and Matlab/Simulink have been used in this simulation platform are described. The focus here...... is on the modelling and simulation time scale aspects. The abilities of these tools are complementary and they can together cover all the modelling aspects of the wind turbines e.g. mechanical loads, power quality, switching, control and grid faults. New models and new control algorithms for wind turbine systems have...

  8. Simulating Social Networks of Online Communities: Simulation as a Method for Sociability Design

    Science.gov (United States)

    Ang, Chee Siang; Zaphiris, Panayiotis

    We propose the use of social simulations to study and support the design of online communities. In this paper, we developed an Agent-Based Model (ABM) to simulate and study the formation of social networks in a Massively Multiplayer Online Role Playing Game (MMORPG) guild community. We first analyzed the activities and the social network (who-interacts-with-whom) of an existing guild community to identify its interaction patterns and characteristics. Then, based on the empirical results, we derived and formalized the interaction rules, which were implemented in our simulation. Using the simulation, we reproduced the observed social network of the guild community as a means of validation. The simulation was then used to examine how various parameters of the community (e.g. the level of activity, the number of neighbors of each agent, etc) could potentially influence the characteristic of the social networks.

  9. Simulations for designing and interpreting intervention trials in infectious diseases.

    Science.gov (United States)

    Halloran, M Elizabeth; Auranen, Kari; Baird, Sarah; Basta, Nicole E; Bellan, Steven E; Brookmeyer, Ron; Cooper, Ben S; DeGruttola, Victor; Hughes, James P; Lessler, Justin; Lofgren, Eric T; Longini, Ira M; Onnela, Jukka-Pekka; Özler, Berk; Seage, George R; Smith, Thomas A; Vespignani, Alessandro; Vynnycky, Emilia; Lipsitch, Marc

    2017-12-29

    Interventions in infectious diseases can have both direct effects on individuals who receive the intervention as well as indirect effects in the population. In addition, intervention combinations can have complex interactions at the population level, which are often difficult to adequately assess with standard study designs and analytical methods. Herein, we urge the adoption of a new paradigm for the design and interpretation of intervention trials in infectious diseases, particularly with regard to emerging infectious diseases, one that more accurately reflects the dynamics of the transmission process. In an increasingly complex world, simulations can explicitly represent transmission dynamics, which are critical for proper trial design and interpretation. Certain ethical aspects of a trial can also be quantified using simulations. Further, after a trial has been conducted, simulations can be used to explore the possible explanations for the observed effects. Much is to be gained through a multidisciplinary approach that builds collaborations among experts in infectious disease dynamics, epidemiology, statistical science, economics, simulation methods, and the conduct of clinical trials.

  10. Cavity design and beam simulations for the APS rf gun

    International Nuclear Information System (INIS)

    Borland, M.

    1991-01-01

    An earlier note discussed the preliminary design of the 1-1/2 cell RF cavity for the APS RF gun. This note describes the final design, including cavity properties and simulation results from the program rf gun. The basic idea for the new design was that the successful SSRL design could be improved upon by reducing fields that had nonlinear dependence on radius. As discussed previously, this would reduce the emittance and produce tighter momentum and time distributions. In addition, it was desirable to increase the fields in the first half-cell relative to the fields in the second half-cell, in order to allow more rapid initial acceleration, which would reduce the effects of space charge. Both of these goals were accomplished in the new design

  11. The design of narrative as an immersive simulation

    OpenAIRE

    gomes, renata

    2005-01-01

    This paper proposes a concept of narrative as the design of an immersive simulation to be experienced by the interactor in a video game. We face this new narrative status as the reconfiguration of a creative process that was initiated in an attempt to generate, in the digital format, a certain concept of narrative inherited from the canonic cinema, but that, faced with the simulative nature of the video game format, was forced to take a different shape. To explain this concept, we draw a brie...

  12. Specific repression of mutant K-RAS by 10-23 DNAzyme: Sensitizing cancer cell to anti-cancer therapies

    International Nuclear Information System (INIS)

    Yu, S.-H.; Wang, T.-H.; Au, L.-C.

    2009-01-01

    Point mutations of the Ras family are frequently found in human cancers at a prevalence rate of 30%. The most common mutation K-Ras(G12V), required for tumor proliferation, survival, and metastasis due to its constitutively active GTPase activity, has provided an ideal target for cancer therapy. 10-23 DNAzyme, an oligodeoxyribonucleotide-based ribonuclease consisting of a 15-nucleotide catalytical domain flanked by two target-specific complementary arms, has been shown to effectively cleave the target mRNA at purine-pyrimidine dinucleotide. Taking advantage of this specific property, 10-23 DNAzyme was designed to cleave mRNA of K-Ras(G12V)(GGU → GUU) at the GU dinucleotide while left the wild-type (WT) K-Ras mRNA intact. The K-Ras(G12V)-specific 10-23 DNAzyme was able to reduce K-Ras(G12V) at both mRNA and protein levels in SW480 cell carrying homozygous K-Ras(G12V). No effect was observed on the WT K-Ras in HEK cells. Although K-Ras(G12V)-specific DNAzymes alone did not inhibit proliferation of SW480 or HEK cells, pre-treatment of this DNAzyme sensitized the K-Ras(G12V) mutant cells to anti-cancer agents such as doxorubicin and radiation. These results offer a potential of using allele-specific 10-23 DNAzyme in combination with other cancer therapies to achieve better effectiveness on cancer treatment.

  13. A system for designing and simulating particle physics experiments

    International Nuclear Information System (INIS)

    Zelazny, R.; Strzalkowski, P.

    1987-01-01

    In view of the rapid development of experimental facilities and their costs, the systematic design and preparation of particle physics experiments have become crucial. A software system is proposed as an aid for the experimental designer, mainly for experimental geometry analysis and experimental simulation. The following model is adopted: the description of an experiment is formulated in a language (here called XL) and put by its processor in a data base. The language is based on the entity-relationship-attribute approach. The information contained in the data base can be reported and analysed by an analyser (called XA) and modifications can be made at any time. In particular, the Monte Carlo methods can be used in experiment simulation for both physical phenomena in experimental set-up and detection analysis. The general idea of the system is based on the design concept of ISDOS project information systems. The characteristics of the simulation module are similar to those of the CERN Geant system, but some extensions are proposed. The system could be treated as a component of greater, integrated software environment for the design of particle physics experiments, their monitoring and data processing. (orig.)

  14. Programmable multi-node quantum network design and simulation

    Science.gov (United States)

    Dasari, Venkat R.; Sadlier, Ronald J.; Prout, Ryan; Williams, Brian P.; Humble, Travis S.

    2016-05-01

    Software-defined networking offers a device-agnostic programmable framework to encode new network functions. Externally centralized control plane intelligence allows programmers to write network applications and to build functional network designs. OpenFlow is a key protocol widely adopted to build programmable networks because of its programmability, flexibility and ability to interconnect heterogeneous network devices. We simulate the functional topology of a multi-node quantum network that uses programmable network principles to manage quantum metadata for protocols such as teleportation, superdense coding, and quantum key distribution. We first show how the OpenFlow protocol can manage the quantum metadata needed to control the quantum channel. We then use numerical simulation to demonstrate robust programmability of a quantum switch via the OpenFlow network controller while executing an application of superdense coding. We describe the software framework implemented to carry out these simulations and we discuss near-term efforts to realize these applications.

  15. Design and simulation for real-time distributed processing systems

    International Nuclear Information System (INIS)

    Legrand, I.C.; Gellrich, A.; Gensah, U.; Leich, H.; Wegner, P.

    1996-01-01

    The aim of this work is to provide a proper framework for the simulation and the optimization of the event building, the on-line third level trigger, and complete event reconstruction processor farm for the future HERA-B experiment. A discrete event, process oriented, simulation developed in concurrent μC++ is used for modelling the farm nodes running with multi-tasking constraints and different types of switching elements and digital signal processors interconnected for distributing the data through the system. An adequate graphic interface to the simulation part which allows to monitor features on-line and to analyze trace files, provides a powerful development tool for evaluating and designing parallel processing architectures. Control software and data flow protocols for event building and dynamic processor allocation are presented for two architectural models. (author)

  16. Dedicated software for diffractive optics design and simulation

    International Nuclear Information System (INIS)

    Firsov, A; Brzhezinskaya, M; Erko, A; Firsov, A; Svintsov, A

    2013-01-01

    An efficient software package for the structure design and simulation of imaging properties of diffraction optical elements has been developed. It operates with point source and consists of: the ZON software, to calculate the structure of an optical element in transmission and reflection; the KRGF software, to simulate the diffraction properties of an ideal optical element with point source; the DS software, to calculate the diffraction properties by taking into consideration material and shadowing effects. Optional software allows simulation with a real non-point source. Zone plate thickness profile, source shape as well as substrate curvature are considered in this calculation. This is especially important for the diffractive focusing elements and gratings at a total external reflection, given that the lateral size of the structure can be up to 1 m. The program package can be used in combination with the Nanomaker software to prepare data for ion and e-beam surface modifications and corrections.

  17. Design of 3D simulation engine for oilfield safety training

    Science.gov (United States)

    Li, Hua-Ming; Kang, Bao-Sheng

    2015-03-01

    Aiming at the demand for rapid custom development of 3D simulation system for oilfield safety training, this paper designs and implements a 3D simulation engine based on script-driven method, multi-layer structure, pre-defined entity objects and high-level tools such as scene editor, script editor, program loader. A scripting language been defined to control the system's progress, events and operating results. Training teacher can use this engine to edit 3D virtual scenes, set the properties of entity objects, define the logic script of task, and produce a 3D simulation training system without any skills of programming. Through expanding entity class, this engine can be quickly applied to other virtual training areas.

  18. New insights into RAS biology reinvigorate interest in mathematical modeling of RAS signaling.

    Science.gov (United States)

    Erickson, Keesha E; Rukhlenko, Oleksii S; Posner, Richard G; Hlavacek, William S; Kholodenko, Boris N

    2018-03-05

    RAS is the most frequently mutated gene across human cancers, but developing inhibitors of mutant RAS has proven to be challenging. Given the difficulties of targeting RAS directly, drugs that impact the other components of pathways where mutant RAS operates may potentially be effective. However, the system-level features, including different localizations of RAS isoforms, competition between downstream effectors, and interlocking feedback and feed-forward loops, must be understood to fully grasp the opportunities and limitations of inhibiting specific targets. Mathematical modeling can help us discern the system-level impacts of these features in normal and cancer cells. New technologies enable the acquisition of experimental data that will facilitate development of realistic models of oncogenic RAS behavior. In light of the wealth of empirical data accumulated over decades of study and the advancement of experimental methods for gathering new data, modelers now have the opportunity to advance progress toward realization of targeted treatment for mutant RAS-driven cancers. Copyright © 2018 Elsevier Ltd. All rights reserved.

  19. High mobility and quantum well transistors design and TCAD simulation

    CERN Document Server

    Hellings, Geert

    2013-01-01

    For many decades, the semiconductor industry has miniaturized transistors, delivering increased computing power to consumers at decreased cost. However, mere transistor downsizing does no longer provide the same improvements. One interesting option to further improve transistor characteristics is to use high mobility materials such as germanium and III-V materials. However, transistors have to be redesigned in order to fully benefit from these alternative materials. High Mobility and Quantum Well Transistors: Design and TCAD Simulation investigates planar bulk Germanium pFET technology in chapters 2-4, focusing on both the fabrication of such a technology and on the process and electrical TCAD simulation. Furthermore, this book shows that Quantum Well based transistors can leverage the benefits of these alternative materials, since they confine the charge carriers to the high-mobility material using a heterostructure. The design and fabrication of one particular transistor structure - the SiGe Implant-Free Qu...

  20. Simulation of gas turbines operating in off-design condition

    Energy Technology Data Exchange (ETDEWEB)

    Walter, Arnaldo [Universidade Estadual de Campinas, SP (Brazil). Faculdade de Engenharia Mecanica. Dept. de Energia]. E-mail: walter@fem.unicamp.br

    2000-07-01

    In many countries thermal power plants based on gas turbines have been the main option for new investment into the electric system due to their relatively high efficiency and low capital cost. Cogeneration systems based on gas turbines have also been an important option for the electric industry. Feasibility studies of power plants based on gas turbine should consider the effect of atmospheric conditions and part-load operation on the machine performance. Doing this, an off-design procedure is required. A G T off-design simulation procedure is described in this paper. Ruston R M was used to validate the simulation procedure that, general sense, presents deviations lower than 2.5% in comparison to manufacturer's data. (author)

  1. An automated methodology development. [software design for combat simulation

    Science.gov (United States)

    Hawley, L. R.

    1985-01-01

    The design methodology employed in testing the applicability of Ada in large-scale combat simulations is described. Ada was considered as a substitute for FORTRAN to lower life cycle costs and ease the program development efforts. An object-oriented approach was taken, which featured definitions of military targets, the capability of manipulating their condition in real-time, and one-to-one correlation between the object states and real world states. The simulation design process was automated by the problem statement language (PSL)/problem statement analyzer (PSA). The PSL/PSA system accessed the problem data base directly to enhance the code efficiency by, e.g., eliminating non-used subroutines, and provided for automated report generation, besides allowing for functional and interface descriptions. The ways in which the methodology satisfied the responsiveness, reliability, transportability, modifiability, timeliness and efficiency goals are discussed.

  2. A design of inverse Taylor projectiles using material simulation

    International Nuclear Information System (INIS)

    Tonks, Michael; Harstad, Eric; Maudlin, Paul; Trujillo, Carl

    2008-01-01

    The classic Taylor cylinder test, in which a right circular cylinder is projected at a rigid anvil, exploits the inertia of the projectile to access strain rates that are difficult to achieve with more traditional uniaxial testing methods. In this work we present our efforts to design inverse Taylor projectiles, in which a tapered projectile becomes a right circular cylinder after impact, from annealed copper and show that the self-correcting geometry leads to a uniform compressive strain in the radial direction. We design projectiles using finite element simulation and optimization that deform as desired in tests with minor deviations in the deformed geometry due to manufacturing error and uncertainty in the initial velocity. The inverse Taylor projectiles designed in this manner provide a simple means of validating constitutive models. This work is a step towards developing a general method of designing Taylor projectiles that provide stress–strain behavior relevant to particular engineering problems

  3. Design and simulation of the direct drive servo system

    Science.gov (United States)

    Ren, Changzhi; Liu, Zhao; Song, Libin; Yi, Qiang; Chen, Ken; Zhang, Zhenchao

    2010-07-01

    As direct drive technology is finding their way into telescope drive designs for its many advantages, it would push to more reliable and cheaper solutions for future telescope complex motion system. However, the telescope drive system based on the direct drive technology is one high integrated electromechanical system, which one complex electromechanical design method is adopted to improve the efficiency, reliability and quality of the system during the design and manufacture circle. The telescope is one ultra-exact, ultra-speed, high precision and huge inertial instrument, which the direct torque motor adopted by the telescope drive system is different from traditional motor. This paper explores the design process and some simulation results are discussed.

  4. RAS in Pregnancy and Preeclampsia and Eclampsia

    Directory of Open Access Journals (Sweden)

    M. Rodriguez

    2012-01-01

    Full Text Available Preeclampsia is a common disease of pregnancy characterized by the presence of hypertension and commitment of many organs, including the brain, secondary to generalized endothelial dysfunction. Its etiology is not known precisely, but it involved several factors, highlighting the renin angiotensin system (RAS, which would have an important role in the origin of multisystem involvement. This paper reviews the evidence supporting the involvement of RAS in triggering the disease, in addition to the components of this system that would be involved and how it eventually produces brain engagement.

  5. Configuration System for Simulation Based Design of Vibratory Bowl Feeders

    DEFF Research Database (Denmark)

    Hansson, Michael Natapon; Mathiesen, Simon; Ellekilde, Lars-Peter

    2017-01-01

    Vibratory bowl feeders are still among the most commonly used production equipment for automated part feeding, where parts are correctly oriented for further manipulation by being conveyed through a set of orienting devices. Designing vibratory bowl feeders involves selecting and sequencing...... a number of these devices that either reorients or rejects the part until a desirable orientation is achieved. To aid the designer in this task, this work presents a configuration system where knowledge of the behaviour for each device is acquired through dynamic simulation, and used to solve...

  6. Robust Multivariable Optimization and Performance Simulation for ASIC Design

    Science.gov (United States)

    DuMonthier, Jeffrey; Suarez, George

    2013-01-01

    Application-specific-integrated-circuit (ASIC) design for space applications involves multiple challenges of maximizing performance, minimizing power, and ensuring reliable operation in extreme environments. This is a complex multidimensional optimization problem, which must be solved early in the development cycle of a system due to the time required for testing and qualification severely limiting opportunities to modify and iterate. Manual design techniques, which generally involve simulation at one or a small number of corners with a very limited set of simultaneously variable parameters in order to make the problem tractable, are inefficient and not guaranteed to achieve the best possible results within the performance envelope defined by the process and environmental requirements. What is required is a means to automate design parameter variation, allow the designer to specify operational constraints and performance goals, and to analyze the results in a way that facilitates identifying the tradeoffs defining the performance envelope over the full set of process and environmental corner cases. The system developed by the Mixed Signal ASIC Group (MSAG) at the Goddard Space Flight Center is implemented as a framework of software modules, templates, and function libraries. It integrates CAD tools and a mathematical computing environment, and can be customized for new circuit designs with only a modest amount of effort as most common tasks are already encapsulated. Customization is required for simulation test benches to determine performance metrics and for cost function computation.

  7. Simulation models and designs for advanced Fischer-Tropsch technology

    Energy Technology Data Exchange (ETDEWEB)

    Choi, G.N.; Kramer, S.J.; Tam, S.S. [Bechtel Corp., San Francisco, CA (United States)

    1995-12-31

    Process designs and economics were developed for three grass-roots indirect Fischer-Tropsch coal liquefaction facilities. A baseline and an alternate upgrading design were developed for a mine-mouth plant located in southern Illinois using Illinois No. 6 coal, and one for a mine-mouth plane located in Wyoming using Power River Basin coal. The alternate design used close-coupled ZSM-5 reactors to upgrade the vapor stream leaving the Fischer-Tropsch reactor. ASPEN process simulation models were developed for all three designs. These results have been reported previously. In this study, the ASPEN process simulation model was enhanced to improve the vapor/liquid equilibrium calculations for the products leaving the slurry bed Fischer-Tropsch reactors. This significantly improved the predictions for the alternate ZSM-5 upgrading design. Another model was developed for the Wyoming coal case using ZSM-5 upgrading of the Fischer-Tropsch reactor vapors. To date, this is the best indirect coal liquefaction case. Sensitivity studies showed that additional cost reductions are possible.

  8. Designing and simulating a nitinol-based micro ejector

    Directory of Open Access Journals (Sweden)

    Yesid Mora Sierra

    2012-01-01

    Full Text Available This paper describes pico-droplet ejector design and simulation. The actuation system was based on two interconnected nitinol membranes’ shape memory effect. Ejected volume was 12pL and it operated at 30°C to 64°C. Ejecting excitation voltage was 12V and the ejecting energy required by actuator operation was 26µJ per drop. These pico-liter ejectors could have applications in making, lubricating and cooling integrated circuits.

  9. Design, modelling and simulation aspects of an ankle rehabilitation device

    Science.gov (United States)

    Racu, C. M.; Doroftei, I.

    2016-08-01

    Ankle injuries are amongst the most common injuries of the lower limb. Besides initial treatment, rehabilitation of the patients plays a crucial role for future activities and proper functionality of the foot. Traditionally, ankle injuries are rehabilitated via physiotherapy, using simple equipment like elastic bands and rollers, requiring intensive efforts of therapists and patients. Thus, the need of robotic devices emerges. In this paper, the design concept and some modelling and simulation aspects of a novel ankle rehabilitation device are presented.

  10. UOE Pipe Manufacturing Process Simulation: Equipment Designing and Construction

    Science.gov (United States)

    Delistoian, Dmitri; Chirchor, Mihael

    2017-12-01

    UOE pipe manufacturing process influence directly on pipeline resilience and operation capacity. At present most spreaded pipe manufacturing method is UOE. This method is based on cold forming. After each technological step appears a certain stress and strain level. For pipe stress strain study is designed and constructed special equipment that simulate entire technological process.UOE pipe equipment is dedicated for manufacturing of longitudinally submerged arc welded DN 400 (16 inch) steel pipe.

  11. Genetic algorithms and Monte Carlo simulation for optimal plant design

    International Nuclear Information System (INIS)

    Cantoni, M.; Marseguerra, M.; Zio, E.

    2000-01-01

    We present an approach to the optimal plant design (choice of system layout and components) under conflicting safety and economic constraints, based upon the coupling of a Monte Carlo evaluation of plant operation with a Genetic Algorithms-maximization procedure. The Monte Carlo simulation model provides a flexible tool, which enables one to describe relevant aspects of plant design and operation, such as standby modes and deteriorating repairs, not easily captured by analytical models. The effects of deteriorating repairs are described by means of a modified Brown-Proschan model of imperfect repair which accounts for the possibility of an increased proneness to failure of a component after a repair. The transitions of a component from standby to active, and vice versa, are simulated using a multiplicative correlation model. The genetic algorithms procedure is demanded to optimize a profit function which accounts for the plant safety and economic performance and which is evaluated, for each possible design, by the above Monte Carlo simulation. In order to avoid an overwhelming use of computer time, for each potential solution proposed by the genetic algorithm, we perform only few hundreds Monte Carlo histories and, then, exploit the fact that during the genetic algorithm population evolution, the fit chromosomes appear repeatedly many times, so that the results for the solutions of interest (i.e. the best ones) attain statistical significance

  12. Design and simulation of permanent magnet synchronous motor control system

    Science.gov (United States)

    Li, Li; Liu, Yongqiu

    2018-06-01

    In recent years, with the development of power electronics, microelectronics, new motor control theory and rare earth permanent magnet materials, permanent magnet synchronous motors have been rapidly applied. Permanent magnet synchronous motors have the advantages of small size, low loss and high efficiency. Today, energy conservation and environmental protection are increasingly valued. It is very necessary to study them. Permanent magnet synchronous motor control system has a wide range of application prospects in the fields of electric vehicles, ships and other transportation. Using the simulation function of MATLAB/SIMULINK, a modular design structure was used to simulate the whole system model of speed loop adjustment, current PI modulation, SVPWM (Space Vector Pulse Width Module) wave generation and double closed loop. The results show that this control method has good robustness, and this method can improve the design efficiency and shorten the system design time. In this article, the analysis of the control principle of modern permanent magnet synchronous motor and the various processes of MATLAB simulation application will be analyzed in detail. The basic theory, basic method and application technology of the permanent magnet synchronous motor control system are systematically introduced.

  13. Quantitative Assays for RAS Pathway Proteins and Phosphorylation States

    Science.gov (United States)

    The NCI CPTAC program is applying its expertise in quantitative proteomics to develop assays for RAS pathway proteins. Targets include key phosphopeptides that should increase our understanding of how the RAS pathway is regulated.

  14. Genetic and Molecular Analysis of Suppressors of Ras Mutations

    National Research Council Canada - National Science Library

    Eastburn, Dennis

    2000-01-01

    .... The study of Caenorhabditis elegans and other model systems has demonstrated that Ras is part of a conserved Ras/MAPK signaling pathway involved in many aspects of development and cell regulation. The C...

  15. Designing a Distributed Space Systems Simulation in Accordance with the Simulation Interoperability Standards Organization (SISO)

    Science.gov (United States)

    Cowen, Benjamin

    2011-01-01

    Simulations are essential for engineering design. These virtual realities provide characteristic data to scientists and engineers in order to understand the details and complications of the desired mission. A standard development simulation package known as Trick is used in developing a source code to model a component (federate in HLA terms). The runtime executive is integrated into an HLA based distributed simulation. TrickHLA is used to extend a Trick simulation for a federation execution, develop a source code for communication between federates, as well as foster data input and output. The project incorporates international cooperation along with team collaboration. Interactions among federates occur throughout the simulation, thereby relying on simulation interoperability. Communication through the semester went on between participants to figure out how to create this data exchange. The NASA intern team is designing a Lunar Rover federate and a Lunar Shuttle federate. The Lunar Rover federate supports transportation across the lunar surface and is essential for fostering interactions with other federates on the lunar surface (Lunar Shuttle, Lunar Base Supply Depot and Mobile ISRU Plant) as well as transporting materials to the desired locations. The Lunar Shuttle federate transports materials to and from lunar orbit. Materials that it takes to the supply depot include fuel and cargo necessary to continue moon-base operations. This project analyzes modeling and simulation technologies as well as simulation interoperability. Each team from participating universities will work on and engineer their own federate(s) to participate in the SISO Spring 2011 Workshop SIW Smackdown in Boston, Massachusetts. This paper will focus on the Lunar Rover federate.

  16. The conceptual design and simulation of 30m RIT

    Science.gov (United States)

    Liu, Zhong; Yichun, Dai; Jin, Zhenyu; Jun, Xu; Lin, Jing

    2008-07-01

    As one of the preliminary research projects of Chinese ELT, 30m RIT--Ring Interferometric Telescope are being simulated and tentatively designed by Yunnan Astronomical Observatory, CAS. The simulations of 30m RIT are mainly included as follows: PSF transform and the image quality at limited photons mode, active control mode of the primary ring mirror, the phasing mode of 30m segmented ring mirror, the turbulent atmosphere and adaptive optics etc. This paper also introduces some tentative design results of 30m RIT, such as the optical design, the conceptual design of the enclosure. The astronomical experiments at seeing limited case and diffraction limited case are introduced in this paper too. A ring aperture mask was put on the entrance pupil of a one meter telescope, real astronomical objects were observed by this "ring telescope" and reconstructed by high resolution imaging techniques such as speckle masking, iterative shift and add methods. The diffraction imaging ability and the full u-v coverage property of a ring aperture were proved by these astronomical experiments.

  17. Design and Simulation of an Electrothermal Actuator Based Rotational Drive

    Science.gov (United States)

    Beeson, Sterling; Dallas, Tim

    2008-10-01

    As a participant in the Micro and Nano Device Engineering (MANDE) Research Experience for Undergraduates program at Texas Tech University, I learned how MEMS devices operate and the limits of their operation. Using specialized AutoCAD-based design software and the ANSYS simulation program, I learned the MEMS fabrication process used at Sandia National Labs, the design limitations of this process, the abilities and drawbacks of micro devices, and finally, I redesigned a MEMS device called the Chevron Torsional Ratcheting Actuator (CTRA). Motion is achieved through electrothermal actuation. The chevron (bent-beam) actuators cause a ratcheting motion on top of a hub-less gear so that as voltage is applied the CTRA spins. The voltage applied needs to be pulsed and the frequency of the pulses determine the angular frequency of the device. The main objective was to design electromechanical structures capable of transforming the electrical signals into mechanical motion without overheating. The design was optimized using finite element analysis in ANSYS allowing multi-physics simulations of our model system.

  18. Design and simulation of the nuSTORM pion beamline

    Energy Technology Data Exchange (ETDEWEB)

    Liu, A., E-mail: aoliu@fnal.gov; Neuffer, D.; Bross, A.

    2015-11-21

    The nuSTORM (neutrinos from STORed Muons) proposal presents a detailed design for a neutrino facility based on a muon storage ring, with muon decay in the production straight section of the ring providing well defined neutrino beams. The facility includes a primary high-energy proton beam line, a target station with pion production and collection, and a pion beamline for pion transportation and injection into a muon decay ring. The nuSTORM design uses “stochastic injection”, in which pions are directed by a chicane, referred to as the Orbit Combination Section (OCS), into the production straight section of the storage ring. Pions that decay within that straight section provide muons within the circulating acceptance of the ring. The design enables injection without kickers or a separate pion decay transport line. The beam line that the pions traverse before being extracted from the decay ring is referred to as the pion beamline. This paper describes the design and simulation of the pion beamline, and includes full beam dynamics simulations of the system.

  19. Design and Control of Full Scale Wave Energy Simulator System

    DEFF Research Database (Denmark)

    Pedersen, Henrik C.; Hansen, Anders Hedegaard; Hansen, Rico Hjerm

    2012-01-01

    For wave energy to become feasible it is a requirement that the efficiency and reliability of the power take-off (PTO) systems are significantly improved. The cost of installing and testing PTO-systems at sea are however very high, and the focus of the current paper is therefore on the design...... of a full scale wave simulator for testing PTO-systems for point absorbers. The main challenge is here to design a system, which mimics the behavior of a wave when interacting with a given PTO-system. The paper includes a description of the developed system, located at Aalborg University......, and the considerations behind the design. Based on the description a model of the system is presented, which, along with a description of the wave theory applied, makes the foundation for the control strategy. The objective of the control strategy is to emulate not only the wave behavior, but also the dynamic wave...

  20. Stochastic simulation and robust design optimization of integrated photonic filters

    Directory of Open Access Journals (Sweden)

    Weng Tsui-Wei

    2016-07-01

    Full Text Available Manufacturing variations are becoming an unavoidable issue in modern fabrication processes; therefore, it is crucial to be able to include stochastic uncertainties in the design phase. In this paper, integrated photonic coupled ring resonator filters are considered as an example of significant interest. The sparsity structure in photonic circuits is exploited to construct a sparse combined generalized polynomial chaos model, which is then used to analyze related statistics and perform robust design optimization. Simulation results show that the optimized circuits are more robust to fabrication process variations and achieve a reduction of 11%–35% in the mean square errors of the 3 dB bandwidth compared to unoptimized nominal designs.

  1. Applying Statistical Design to Control the Risk of Over-Design with Stochastic Simulation

    Directory of Open Access Journals (Sweden)

    Yi Wu

    2010-02-01

    Full Text Available By comparing a hard real-time system and a soft real-time system, this article elicits the risk of over-design in soft real-time system designing. To deal with this risk, a novel concept of statistical design is proposed. The statistical design is the process accurately accounting for and mitigating the effects of variation in part geometry and other environmental conditions, while at the same time optimizing a target performance factor. However, statistical design can be a very difficult and complex task when using clas-sical mathematical methods. Thus, a simulation methodology to optimize the design is proposed in order to bridge the gap between real-time analysis and optimization for robust and reliable system design.

  2. Status of neutron complex of INR RAS

    Energy Technology Data Exchange (ETDEWEB)

    Grachev, M I; Koptelov, E A; Kravchuk, L V; Matveev, V A; Perekrestenko, A D; Sidorkin, S F [Institute for Nuclear Research of Russian Academy of Sciences, Prospekt, Moscow (Russian Federation); Stavissky, Y Y

    2001-03-01

    The neutron complex of INR RAS consists of two sources of neutrons, beam stop, lead slowing down spectrometer and solid state spectrometers. The description of objects and their condition, the program of planned researches, co-operation with other institutes of the Moscow Region, progress reached for last two years are introduced in the article. (author)

  3. Status of neutron complex of INR RAS

    International Nuclear Information System (INIS)

    Grachev, M.I.; Koptelov, E.A.; Kravchuk, L.V.; Matveev, V.A.; Perekrestenko, A.D.; Sidorkin, S.F.; Stavissky, Y.Y.

    2001-01-01

    The neutron complex of INR RAS consists of two sources of neutrons, beam stop, lead slowing down spectrometer and solid state spectrometers. The description of objects and their condition, the program of planned researches, co-operation with other institutes of the Moscow Region, progress reached for last two years are introduced in the article. (author)

  4. Using simulation to aid trial design: Ring-vaccination trials.

    Directory of Open Access Journals (Sweden)

    Matt David Thomas Hitchings

    2017-03-01

    Full Text Available The 2014-6 West African Ebola epidemic highlights the need for rigorous, rapid clinical trial methods for vaccines. A challenge for trial design is making sample size calculations based on incidence within the trial, total vaccine effect, and intracluster correlation, when these parameters are uncertain in the presence of indirect effects of vaccination.We present a stochastic, compartmental model for a ring vaccination trial. After identification of an index case, a ring of contacts is recruited and either vaccinated immediately or after 21 days. The primary outcome of the trial is total vaccine effect, counting cases only from a pre-specified window in which the immediate arm is assumed to be fully protected and the delayed arm is not protected. Simulation results are used to calculate necessary sample size and estimated vaccine effect. Under baseline assumptions about vaccine properties, monthly incidence in unvaccinated rings and trial design, a standard sample-size calculation neglecting dynamic effects estimated that 7,100 participants would be needed to achieve 80% power to detect a difference in attack rate between arms, while incorporating dynamic considerations in the model increased the estimate to 8,900. This approach replaces assumptions about parameters at the ring level with assumptions about disease dynamics and vaccine characteristics at the individual level, so within this framework we were able to describe the sensitivity of the trial power and estimated effect to various parameters. We found that both of these quantities are sensitive to properties of the vaccine, to setting-specific parameters over which investigators have little control, and to parameters that are determined by the study design.Incorporating simulation into the trial design process can improve robustness of sample size calculations. For this specific trial design, vaccine effectiveness depends on properties of the ring vaccination design and on the

  5. Design, modeling, simulation and evaluation of a distributed energy system

    Science.gov (United States)

    Cultura, Ambrosio B., II

    This dissertation presents the design, modeling, simulation and evaluation of distributed energy resources (DER) consisting of photovoltaics (PV), wind turbines, batteries, a PEM fuel cell and supercapacitors. The distributed energy resources installed at UMass Lowell consist of the following: 2.5kW PV, 44kWhr lead acid batteries and 1500W, 500W & 300W wind turbines, which were installed before year 2000. Recently added to that are the following: 10.56 kW PV array, 2.4 kW wind turbine, 29 kWhr Lead acid batteries, a 1.2 kW PEM fuel cell and 4-140F supercapacitors. Each newly added energy resource has been designed, modeled, simulated and evaluated before its integration into the existing PV/Wind grid-connected system. The Mathematical and Simulink model of each system was derived and validated by comparing the simulated and experimental results. The Simulated results of energy generated from a 10.56kW PV system are in good agreement with the experimental results. A detailed electrical model of a 2.4kW wind turbine system equipped with a permanent magnet generator, diode rectifier, boost converter and inverter is presented. The analysis of the results demonstrates the effectiveness of the constructed simulink model, and can be used to predict the performance of the wind turbine. It was observed that a PEM fuel cell has a very fast response to load changes. Moreover, the model has validated the actual operation of the PEM fuel cell, showing that the simulated results in Matlab Simulink are consistent with the experimental results. The equivalent mathematical equation, derived from an electrical model of the supercapacitor, is used to simulate its voltage response. The model is completely capable of simulating its voltage behavior, and can predict the charge time and discharge time of voltages on the supercapacitor. The bi-directional dc-dc converter was designed in order to connect the 48V battery bank storage to the 24V battery bank storage. This connection was

  6. Standard High Solids Vessel Design De-inventory Simulant Qualification

    Energy Technology Data Exchange (ETDEWEB)

    Fiskum, Sandra K. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Burns, Carolyn A.M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Gauglitz, Phillip A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Linn, Diana T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Peterson, Reid A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Smoot, Margaret R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2017-09-12

    The Hanford Tank Waste Treatment and Immobilization Plant (WTP) is working to develop a Standard High Solids Vessel Design (SHSVD) process vessel. To support testing of this new design, WTP engineering staff requested that a Newtonian simulant be developed that would represent the de-inventory (residual high-density tank solids cleanout) process. Its basis and target characteristics are defined in 24590-WTP-ES-ENG-16-021 and implemented through PNNL Test Plan TP-WTPSP-132 Rev. 1.0. This document describes the de-inventory Newtonian carrier fluid (DNCF) simulant composition that will satisfy the basis requirement to mimic the density (1.18 g/mL ± 0.1 g/mL) and viscosity (2.8 cP ± 0.5 cP) of 5 M NaOH at 25 °C.1 The simulant viscosity changes significantly with temperature. Therefore, various solution compositions may be required, dependent on the test stand process temperature range, to meet these requirements. Table ES.1 provides DNCF compositions at selected temperatures that will meet the density and viscosity specifications as well as the temperature range at which the solution will meet the acceptable viscosity tolerance.

  7. Examination of VDR/RXR/DRIP205 Interaction, Intranuclear Localization, and DNA Binding in Ras-Transformed Keratinocytes and Its Implication for Designing Optimal Vitamin D Therapy in Cancer.

    Science.gov (United States)

    Jusu, Sylvester; Presley, John F; Williams, Chris; Das, Sanjoy Kumar; Jean-Claude, Bertrand; Kremer, Richard

    2018-03-01

    Retinoid X receptor (RXR) occupies a central position within the nuclear receptor superfamily, serving as an obligatory partner to numerous other nuclear receptors, including vitamin D receptor (VDR). In the current study, we examined whether phosphorylation of RXRα at serine 260 affects VDR/RXR and VDR interacting protein (DRIP) 205 coactivator recruitment, interactions, and binding of the VDR/human RXRα (hRXRα)/DRIP205 complex to chromatin. Serine 260 is a critical amino acid on the hRXRα that is located in close spatial proximity to regions of coactivator and corepressor interactions. Using fluorescence resonance energy transfer and immunofluorescence studies, we showed that the physical interaction between hRXRα and DRIP205 coactivator was impaired in human keratinocytes with the ras oncogene (HPK1Aras) or transfected with the wild-type hRXRα. Furthermore, the nuclear colocalization of VDR/DRIP205, hRXRα/DRIP205, and VDR/hRXRα/DRIP205 complex binding to chromatin is impaired in the HPK1Aras cells when compared with the normal human keratinocytes (HPK1A cells). However, transfection with the nonphosphorylatable hRXRα (S260A) mutant or treatment with the mitogen-activated protein kinase (MAPK) inhibitor UO126 rescued their nuclear localization, interaction, and binding of the complex to chromatin in the HPK1Aras cells. In summary, we have demonstrated, using highly specific intracellular tagging methods in live and fixed cells, important alterations of the vitamin D signaling system in cancer cells in which the ras-raf-MAPK system is activated, suggesting that specific inhibition of this commonly activated pathway could be targeted therapeutically to enhance vitamin D efficacy. Copyright © 2018 Endocrine Society.

  8. Reactor controller design using genetic algorithms with simulated annealing

    International Nuclear Information System (INIS)

    Erkan, K.; Buetuen, E.

    2000-01-01

    This chapter presents a digital control system for ITU TRIGA Mark-II reactor using genetic algorithms with simulated annealing. The basic principles of genetic algorithms for problem solving are inspired by the mechanism of natural selection. Natural selection is a biological process in which stronger individuals are likely to be winners in a competing environment. Genetic algorithms use a direct analogy of natural evolution. Genetic algorithms are global search techniques for optimisation but they are poor at hill-climbing. Simulated annealing has the ability of probabilistic hill-climbing. Thus, the two techniques are combined here to get a fine-tuned algorithm that yields a faster convergence and a more accurate search by introducing a new mutation operator like simulated annealing or an adaptive cooling schedule. In control system design, there are currently no systematic approaches to choose the controller parameters to obtain the desired performance. The controller parameters are usually determined by test and error with simulation and experimental analysis. Genetic algorithm is used automatically and efficiently searching for a set of controller parameters for better performance. (orig.)

  9. Demonstration of pb-PSHA with Ras-Elhekma earthquake, Egypt

    Directory of Open Access Journals (Sweden)

    Elsayed Fergany

    2017-06-01

    Full Text Available The main goal of this work is to: (1 argue for the importance of a physically-based probabilistic seismic hazard analysis (pb-PSHA methodology and show examples to support the argument from recent events, (2 demonstrate the methodology with the ground motion simulations of May 28, 1998, Mw = 5.5 Ras-Elhekma earthquake, north Egypt. The boundaries for the possible rupture parameters that may have been identified prior to the 1998 Ras-Elhekma earthquake were estimated. A range of simulated ground-motions for the Ras-Elhekma earthquake was “predicted” for frequency 0.5–25 Hz at three sites, where the large earthquake was recorded, with average epicentral distances of 220 km. The best rupture model of the 1998 Ras-Elhekma earthquake was identified by calculated the goodness of fit between observed and synthesized records at sites FYM, HAG, and KOT. We used the best rupture scenario of the 1998 earthquake to synthesize the ground motions at interested sites where the main shock was not recorded. Based on the good fit of simulated and observed seismograms, we concluded that this methodology can provide realistic ground motion of an earthquake and highly recommended for engineering purposes in advance or foregoing large earthquakes at non record sites. We propose that there is a need for this methodology for good-representing the true hazard with reducing uncertainties.

  10. The design and simulation of UHF RFID microstrip antenna

    Science.gov (United States)

    Chen, Xiangqun; Huang, Rui; Shen, Liman; Liu, Liping; Xiong, Dezhi; Xiao, Xiangqi; Liu, Mouhai; Renheng, Xu

    2018-02-01

    At present, China has delineated UHF RFID communicating frequency range which is 840 ∼ 845 MHz and 920 ∼ 925 MHz, but most UHF microstrip antenna don’t carry out this standard, that leads to radio frequency pollution. In order to solve the problems above, a method combining theory and simulation is adopted. Combining with a new ceramic material, a 925.5 MHz RFID microstrip antenna is designed, which is optimized and simulated by HFSS software. The results show that the VSWR of this RFID microstrip antenna is relatively small in the vicinity of 922.5 MHz, the gain is 2.1 dBi, which can be widely used in China’s UHF RFID communicating equipments.

  11. Simulation approaches to probabilistic structural design at the component level

    International Nuclear Information System (INIS)

    Stancampiano, P.A.

    1978-01-01

    In this paper, structural failure of large nuclear components is viewed as a random process with a low probability of occurrence. Therefore, a statistical interpretation of probability does not apply and statistical inferences cannot be made due to the sparcity of actual structural failure data. In such cases, analytical estimates of the failure probabilities may be obtained from stress-strength interference theory. Since the majority of real design applications are complex, numerical methods are required to obtain solutions. Monte Carlo simulation appears to be the best general numerical approach. However, meaningful applications of simulation methods suggest research activities in three categories: methods development, failure mode models development, and statistical data models development. (Auth.)

  12. Design and construction of a low cost solar simulator

    International Nuclear Information System (INIS)

    Supranto; Daud, W.R.W.; Sopian, K.; Othman, M.Y.; Yatim, B.

    2000-01-01

    A solar simulator has been designed and constructed for indoor testing for solar collectors. The simulator consists of 45 halogen lamps. Each lamp has a rated power of a 300 watts. The lamps in ten rows where each row consists of 4 to 5 lamps. The lamps occupied area 6 m 2 . Dimmers are used to control the amount of lamp intensities. The spacing between the lamps and the collector is about 150 cm. The intensities of the lamps are measured using a pyranometer. The intensity contours or mappings for minimum and maximum average pyranometer readings about 280 to 640 W/m 2 are produced, with errors are about of 3.16 % to 4.5 %. (Author)

  13. Design of virtual SCADA simulation system for pressurized water reactor

    International Nuclear Information System (INIS)

    Wijaksono, Umar; Abdullah, Ade Gafar; Hakim, Dadang Lukman

    2016-01-01

    The Virtual SCADA system is a software-based Human-Machine Interface that can visualize the process of a plant. This paper described the results of the virtual SCADA system design that aims to recognize the principle of the Nuclear Power Plant type Pressurized Water Reactor. This simulation uses technical data of the Nuclear Power Plant Unit Olkiluoto 3 in Finland. This device was developed using Wonderware Intouch, which is equipped with manual books for each component, animation links, alarm systems, real time and historical trending, and security system. The results showed that in general this device can demonstrate clearly the principles of energy flow and energy conversion processes in Pressurized Water Reactors. This virtual SCADA simulation system can be used as instructional media to recognize the principle of Pressurized Water Reactor

  14. Design of virtual SCADA simulation system for pressurized water reactor

    Energy Technology Data Exchange (ETDEWEB)

    Wijaksono, Umar, E-mail: umar.wijaksono@student.upi.edu; Abdullah, Ade Gafar; Hakim, Dadang Lukman [Electrical Power System Research Group, Department of Electrical Engineering Education, Jl. Dr. Setiabudi No. 207 Bandung, Indonesia 40154 (Indonesia)

    2016-02-08

    The Virtual SCADA system is a software-based Human-Machine Interface that can visualize the process of a plant. This paper described the results of the virtual SCADA system design that aims to recognize the principle of the Nuclear Power Plant type Pressurized Water Reactor. This simulation uses technical data of the Nuclear Power Plant Unit Olkiluoto 3 in Finland. This device was developed using Wonderware Intouch, which is equipped with manual books for each component, animation links, alarm systems, real time and historical trending, and security system. The results showed that in general this device can demonstrate clearly the principles of energy flow and energy conversion processes in Pressurized Water Reactors. This virtual SCADA simulation system can be used as instructional media to recognize the principle of Pressurized Water Reactor.

  15. Design, modeling and simulation of MEMS-based silicon Microneedles

    International Nuclear Information System (INIS)

    Amin, F; Ahmed, S

    2013-01-01

    The advancement in semiconductor process engineering and nano-scale fabrication technology has made it convenient to transport specific biological fluid into or out of human skin with minimum discomfort. Fluid transdermal delivery systems such as Microneedle arrays are one such emerging and exciting Micro-Electro Mechanical System (MEMS) application which could lead to a total painless fluid delivery into skin with controllability and desirable yield. In this study, we aimed to revisit the problem with modeling, design and simulations carried out for MEMS based silicon hollow out of plane microneedle arrays for biomedical applications particularly for transdermal drug delivery. An approximate 200 μm length of microneedle with 40 μm diameter of lumen has been successfully shown formed by isotropic and anisotropic etching techniques using MEMS Pro design tool. These microneedles are arranged in size of 2 × 4 matrix array with center to center spacing of 750 μm. Furthermore, comparisons for fluid flow characteristics through these microneedle channels have been modeled with and without the contribution of the gravitational forces using mathematical models derived from Bernoulli Equation. Physical Process simulations have also been performed on TCAD SILVACO to optimize the design of these microneedles aligned with the standard Si-Fabrication lines.

  16. Design, modeling and simulation of MEMS-based silicon Microneedles

    Science.gov (United States)

    Amin, F.; Ahmed, S.

    2013-06-01

    The advancement in semiconductor process engineering and nano-scale fabrication technology has made it convenient to transport specific biological fluid into or out of human skin with minimum discomfort. Fluid transdermal delivery systems such as Microneedle arrays are one such emerging and exciting Micro-Electro Mechanical System (MEMS) application which could lead to a total painless fluid delivery into skin with controllability and desirable yield. In this study, we aimed to revisit the problem with modeling, design and simulations carried out for MEMS based silicon hollow out of plane microneedle arrays for biomedical applications particularly for transdermal drug delivery. An approximate 200 μm length of microneedle with 40 μm diameter of lumen has been successfully shown formed by isotropic and anisotropic etching techniques using MEMS Pro design tool. These microneedles are arranged in size of 2 × 4 matrix array with center to center spacing of 750 μm. Furthermore, comparisons for fluid flow characteristics through these microneedle channels have been modeled with and without the contribution of the gravitational forces using mathematical models derived from Bernoulli Equation. Physical Process simulations have also been performed on TCAD SILVACO to optimize the design of these microneedles aligned with the standard Si-Fabrication lines.

  17. Building interactive simulations in a Web page design program.

    Science.gov (United States)

    Kootsey, J Mailen; Siriphongs, Daniel; McAuley, Grant

    2004-01-01

    A new Web software architecture, NumberLinX (NLX), has been integrated into a commercial Web design program to produce a drag-and-drop environment for building interactive simulations. NLX is a library of reusable objects written in Java, including input, output, calculation, and control objects. The NLX objects were added to the palette of available objects in the Web design program to be selected and dropped on a page. Inserting an object in a Web page is accomplished by adding a template block of HTML code to the page file. HTML parameters in the block must be set to user-supplied values, so the HTML code is generated dynamically, based on user entries in a popup form. Implementing the object inspector for each object permits the user to edit object attributes in a form window. Except for model definition, the combination of the NLX architecture and the Web design program permits construction of interactive simulation pages without writing or inspecting code.

  18. Design and simulation of an accelerating and focusing system

    Directory of Open Access Journals (Sweden)

    A Sadeghipanah

    2011-06-01

    Full Text Available Electrostatic focusing lenses have a vast field of applications in electrostatic accelerators and particularly in electron guns. In this paper, we first express a parametric mathematical analysis of an electrostatic accelerator and focusing system for an electron beam. Next, we At design a system of electron emission slit, accelerating electrodes and focusing lens for an electron beam emitted from a cathode with 4 mm radius and 2 mA current, in a distance less than 10 cm and up to the energy of 30 keV with the beam divergence less than 5°. This is achieved by solving the yielded equations in mathematical analysis using MATLAB. At the end, we simulate the behavior of above electron beam in the designed accelerating and focusing system using CST EM Studio. The results of simulation are in high agreement with required specifications of the electron beam, showing the accuracy of the used method in analysis and design of the accelerating and focusing system.

  19. Integrated predictive modelling simulations of burning plasma experiment designs

    International Nuclear Information System (INIS)

    Bateman, Glenn; Onjun, Thawatchai; Kritz, Arnold H

    2003-01-01

    Models for the height of the pedestal at the edge of H-mode plasmas (Onjun T et al 2002 Phys. Plasmas 9 5018) are used together with the Multi-Mode core transport model (Bateman G et al 1998 Phys. Plasmas 5 1793) in the BALDUR integrated predictive modelling code to predict the performance of the ITER (Aymar A et al 2002 Plasma Phys. Control. Fusion 44 519), FIRE (Meade D M et al 2001 Fusion Technol. 39 336), and IGNITOR (Coppi B et al 2001 Nucl. Fusion 41 1253) fusion reactor designs. The simulation protocol used in this paper is tested by comparing predicted temperature and density profiles against experimental data from 33 H-mode discharges in the JET (Rebut P H et al 1985 Nucl. Fusion 25 1011) and DIII-D (Luxon J L et al 1985 Fusion Technol. 8 441) tokamaks. The sensitivities of the predictions are evaluated for the burning plasma experimental designs by using variations of the pedestal temperature model that are one standard deviation above and below the standard model. Simulations of the fusion reactor designs are carried out for scans in which the plasma density and auxiliary heating power are varied

  20. Method and Tool for Design Process Navigation and Automatic Generation of Simulation Models for Manufacturing Systems

    Science.gov (United States)

    Nakano, Masaru; Kubota, Fumiko; Inamori, Yutaka; Mitsuyuki, Keiji

    Manufacturing system designers should concentrate on designing and planning manufacturing systems instead of spending their efforts on creating the simulation models to verify the design. This paper proposes a method and its tool to navigate the designers through the engineering process and generate the simulation model automatically from the design results. The design agent also supports collaborative design projects among different companies or divisions with distributed engineering and distributed simulation techniques. The idea was implemented and applied to a factory planning process.

  1. Solar air heating system: design and dynamic simulation

    Science.gov (United States)

    Bououd, M.; Hachchadi, O.; Janusevicius, K.; Martinaitis, V.; Mechaqrane, A.

    2018-05-01

    The building sector is one of the big energy consumers in Morocco, accounting for about 23% of the country’s total energy consumption. Regarding the population growth, the modern lifestyle requiring more comfort and the increase of the use rate of electronic devices, the energy consumption will continue to increase in the future. In this context, the introduction of renewable energy systems, along with energy efficiency, is becoming a key factor in reducing the energy bill of buildings. This study focuses on the design and dynamic simulation of an air heating system for the mean categories of the tertiary sector where the area exceeds 750 m3. Heating system has been designed via a dynamic simulation environment (TRNSYS) to estimate the produced temperature and airflow rate by one system consisting of three essential components: vacuum tube solar collector, storage tank and water-to-air finned heat exchanger. The performances estimation of this system allows us to evaluate its capacity to meet the heating requirements in Ifrane city based on the prescriptive approach according to the Moroccan Thermal Regulation. The simulation results show that in order to maintain a comfort temperature of 20°C in a building of 750m3, the places requires a thermal powers of approximately 21 kW, 29 kW and 32 kW, respectively, for hotels, hospitals, administrative and public-school. The heat generation is ensured by a solar collector areas of 5 m², 7 m² and 10 m², respectively, for hotels, hospitals, administrative and public-school spaces, a storage tank of 2 m3 and a finned heat exchanger with 24 tubes. The finned tube bundles have been modelled and integrated into the system design via a Matlab code. The heating temperature is adjusted via two controllers to ensure a constant air temperature of 20°C during the heating periods.

  2. Design and simulation on the morphing composite propeller (Conference Presentation)

    Science.gov (United States)

    Chen, Fanlong; Li, Qinyu; Liu, Liwu; Lan, Xin; Liu, Yanju; Leng, Jinsong

    2017-04-01

    As one of the most crucial part of the unmanned underwater vehicle (UUV), the composite propeller plays an important role on the UUV's performance. As the composite propeller behaves excellent properties in hydroelastic facet and acoustic suppression, it attracts increasing attentions all over the globe. This paper goes a step further based on this idea, and comes up with a novel concept of "morphing composite propeller" (MCP) to improve the performance of the conventional composite propeller (CCP) to anticipate the improved propeller can perform better to propel the UUV. Based on the new concept, a novel MCP is designed. Each blade of the propeller is assembled with an active rotatable flap (ARF) to change the blade's local camber with flap rotation. Then the transmission mechanism (TM) has been designed and housed in the propeller blade to push the ARF. With the ARF rotating, the UUV can be propelled by different thrusts under certain rotation velocities of the propeller. Based on the design, the Fluent is exploited to analyze the fluid dynamics around the propeller. Finally, based on the design and hydrodynamic analysis, the structural response for the novel morphing composite propeller is calculated. The propeller blade is simplified and layered with composite materials. And the structure response of an MCP is obtained with various rotation angle under the hydrodynamic pressure. This simulation can instruct the design and fabrication techniques of the MCP.

  3. Design and simulation for a hydraulic actuated quadruped robot

    International Nuclear Information System (INIS)

    Rong, Xuewen; Li, Yibin; Li, Bin; Ruan, Jiuhong

    2012-01-01

    This paper describes the mechanical configuration of a quadruped robot firstly. Each of the four legs consists of three rotary joints. All joints of the robot are actuated by linear hydraulic servo cylinders. Then it deduces the forward and inverse kinematic equations for four legs with D-H transformation matrices. Furthermore, it gives a composite foot trajectory composed of cubic curve and straight line, which greatly reduces the velocity and acceleration fluctuations of the torso along forward and vertical directions. Finally, dynamics cosimulation is given with MSC.ADAMS and MATLAB. The results of co-simulation provide important guidance to mechanism design and parameters preference for the linear hydraulic servo cylinders

  4. Fisher information in the design of computer simulation experiments

    Energy Technology Data Exchange (ETDEWEB)

    StehlIk, Milan; Mueller, Werner G [Department of Applied Statistics, Johannes-Kepler-University Linz Freistaedter Strasse 315, A-4040 Linz (Austria)], E-mail: Milan.Stehlik@jku.at, E-mail: Werner.Mueller@jku.at

    2008-11-01

    The concept of Fisher information is conveniently used as a basis for designing efficient experiments. However, if the output stems from computer simulations they are often approximated as realizations of correlated random fields. Consequently, the conditions under which Fisher information may be suitable must be restated. In the paper we intend to give some simple but illuminating examples for these cases. 'Random phenomena have increasing importance in Engineering and Physics, therefore theoretical results are strongly needed. But there is a gap between the probability theory used by mathematicians and practitioners. Two very different languages have been generated in this way...' (Paul Kree, Paris 1995)

  5. Fisher information in the design of computer simulation experiments

    International Nuclear Information System (INIS)

    StehlIk, Milan; Mueller, Werner G

    2008-01-01

    The concept of Fisher information is conveniently used as a basis for designing efficient experiments. However, if the output stems from computer simulations they are often approximated as realizations of correlated random fields. Consequently, the conditions under which Fisher information may be suitable must be restated. In the paper we intend to give some simple but illuminating examples for these cases. 'Random phenomena have increasing importance in Engineering and Physics, therefore theoretical results are strongly needed. But there is a gap between the probability theory used by mathematicians and practitioners. Two very different languages have been generated in this way...' (Paul Kree, Paris 1995)

  6. APRON: A Cellular Processor Array Simulation and Hardware Design Tool

    Science.gov (United States)

    Barr, David R. W.; Dudek, Piotr

    2009-12-01

    We present a software environment for the efficient simulation of cellular processor arrays (CPAs). This software (APRON) is used to explore algorithms that are designed for massively parallel fine-grained processor arrays, topographic multilayer neural networks, vision chips with SIMD processor arrays, and related architectures. The software uses a highly optimised core combined with a flexible compiler to provide the user with tools for the design of new processor array hardware architectures and the emulation of existing devices. We present performance benchmarks for the software processor array implemented on standard commodity microprocessors. APRON can be configured to use additional processing hardware if necessary and can be used as a complete graphical user interface and development environment for new or existing CPA systems, allowing more users to develop algorithms for CPA systems.

  7. Design and Implementation of Software for Resistance Welding Process Simulations

    DEFF Research Database (Denmark)

    Zhang, Wenqi

    2003-01-01

    Based on long time engineering research and dedicated collaborations with industry, a new welding software, SORPAS, has been developed for simulation of resistance projection and spot welding processes applying the powerful finite element method (FEM). In order to make the software directly usabl...... equipment manufacturers...... by engineers and technicians in industry, all of the important parameters in resistance welding are considered and automatically implemented into the software. With the specially designed graphic user interface for Windows, engineers (even without prior knowledge of FEM) can quickly learn and easily operate...... and utilize the software. All industrial users, including welding engineers from DaimlerChrysler, Volkswangen, PSA Peugeot Citroen, VOLVO, Siemens, ABB and so on, have started using the software just after taking a one-day training course. With the user-friendly facilities for flexible geometric design...

  8. APRON: A Cellular Processor Array Simulation and Hardware Design Tool

    Directory of Open Access Journals (Sweden)

    David R. W. Barr

    2009-01-01

    Full Text Available We present a software environment for the efficient simulation of cellular processor arrays (CPAs. This software (APRON is used to explore algorithms that are designed for massively parallel fine-grained processor arrays, topographic multilayer neural networks, vision chips with SIMD processor arrays, and related architectures. The software uses a highly optimised core combined with a flexible compiler to provide the user with tools for the design of new processor array hardware architectures and the emulation of existing devices. We present performance benchmarks for the software processor array implemented on standard commodity microprocessors. APRON can be configured to use additional processing hardware if necessary and can be used as a complete graphical user interface and development environment for new or existing CPA systems, allowing more users to develop algorithms for CPA systems.

  9. Design-based research in designing the model for educating simulation facilitators.

    Science.gov (United States)

    Koivisto, Jaana-Maija; Hannula, Leena; Bøje, Rikke Buus; Prescott, Stephen; Bland, Andrew; Rekola, Leena; Haho, Päivi

    2018-03-01

    The purpose of this article is to introduce the concept of design-based research, its appropriateness in creating education-based models, and to describe the process of developing such a model. The model was designed as part of the Nurse Educator Simulation based learning project, funded by the EU's Lifelong Learning program (2013-1-DK1-LEO05-07053). The project partners were VIA University College, Denmark, the University of Huddersfield, UK and Metropolia University of Applied Sciences, Finland. As an outcome of the development process, "the NESTLED model for educating simulation facilitators" (NESTLED model) was generated. This article also illustrates five design principles that could be applied to other pedagogies. Copyright © 2018 Elsevier Ltd. All rights reserved.

  10. Genetic analysis of Ras genes in epidermal development and tumorigenesis

    Science.gov (United States)

    Drosten, Matthias; Lechuga, Carmen G; Barbacid, Mariano

    2013-01-01

    Proliferation and differentiation of epidermal keratinocytes are tightly controlled to ensure proper development and homeostasis of the epidermis. The Ras family of small GTPases has emerged as a central node in the coordination of cell proliferation in the epidermis. Recent genetic evidence from mouse models has revealed that the intensity of Ras signaling modulates the proliferative capacity of epidermal keratinocytes. Interfering with Ras signaling either by combined elimination of the 3 Ras genes from the basal layer of the epidermis or by overexpression of dominant-negative Ras isoforms caused epidermal thinning due to hypoproliferation of keratinocytes. In contrast, overexpression of oncogenic Ras mutants in different epidermal cell layers led to hyperproliferative phenotypes including the development of papillomas and squamous cell carcinomas. Here, we discuss the value of loss- and gain-of-function studies in mouse models to assess the role of Ras signaling in the control of epidermal proliferation. PMID:24150175

  11. Integrating Multibody Simulation and CFD: toward Complex Multidisciplinary Design Optimization

    Science.gov (United States)

    Pieri, Stefano; Poloni, Carlo; Mühlmeier, Martin

    This paper describes the use of integrated multidisciplinary analysis and optimization of a race car model on a predefined circuit. The objective is the definition of the most efficient geometric configuration that can guarantee the lowest lap time. In order to carry out this study it has been necessary to interface the design optimization software modeFRONTIER with the following softwares: CATIA v5, a three dimensional CAD software, used for the definition of the parametric geometry; A.D.A.M.S./Motorsport, a multi-body dynamic simulation software; IcemCFD, a mesh generator, for the automatic generation of the CFD grid; CFX, a Navier-Stokes code, for the fluid-dynamic forces prediction. The process integration gives the possibility to compute, for each geometrical configuration, a set of aerodynamic coefficients that are then used in the multiboby simulation for the computation of the lap time. Finally an automatic optimization procedure is started and the lap-time minimized. The whole process is executed on a Linux cluster running CFD simulations in parallel.

  12. Modern design of far-field target motion simulators

    Science.gov (United States)

    Hauser, Robin; Swamp, Michael; Havlicsek, Howard

    2006-05-01

    Target Motion Simulators (TMS) are often used in conjunction with Flight Motion Simulators (FMS) to provide a realistic simulation of tracking and target engagement. For near-field applications, the TMS has typically been implemented with two additional gimbals around the FMS. For far-field applications, such as a radar, the TMS has traditionally been implemented with curvilinear X-Y Frames. A curvilinear frame placed at the proper distance from the FMS has the benefit of always pointing the Target back to the FMS intersection of axes. In most cases the curvilinear TMS provides good results. However, the curvilinear TMS lacks the possibility to change the distance between Target and Seeker, which is needed for operation with different radar wavelengths. Acutronic has developed a new approach using a flat frame (X-Y) TMS coupled with a gimballed payload mount that has the possibility of being used at various distances without losing the functionality of continuous pointing back to the seeker. This paper describes the electro-mechanical design and gives an overview of the Computer and Controllers used. It further addresses the problem of coordination transformation that is needed to obtain the correct pointing.

  13. Design and simulations for RFPI system test jig

    International Nuclear Information System (INIS)

    Keshwani, Rajesh; Khole, Shailesh; Sujo, C.I.; Shukla, Hitesh; Afaash, M.; Bharade, Sandeep; Joshi, Gopal

    2015-01-01

    RFPI system for condition monitoring and protection of RF systems of LEHIPA has been designed. The intention of this system is to protect and monitor different high power RF components. The system consists of variety of analog and digital cards to process, acquire and monitor signals from RF sensors, photo multiplier tubes (PMT), field emission probes, photo sensors, etc. The system can also accept and process digital inputs or contacts and analog input signals from other subsystems, indicating their status. It comprises of analog signal processing electronics, condition monitoring, data acquisition and fault reporting features. Since RFPI system should process and take action within prescribed time limit, the testing of system is critical issue. In order to carry out stand-alone field testing of such elaborate electronic system, variety of carefully designed electronic test circuit with suitable rangeability is required. These include fast current sources, fast amplifiers, fast rectifiers, etc. This paper elaborates on specifications, design approach, circuit design and simulations for various circuits used in test jig

  14. Operationalising elaboration theory for simulation instruction design: a Delphi study.

    Science.gov (United States)

    Haji, Faizal A; Khan, Rabia; Regehr, Glenn; Ng, Gary; de Ribaupierre, Sandrine; Dubrowski, Adam

    2015-06-01

    The aim of this study was to assess the feasibility of incorporating the Delphi process within the simplifying conditions method (SCM) described in elaboration theory (ET) to identify conditions impacting the complexity of procedural skills for novice learners. We generated an initial list of conditions impacting the complexity of lumbar puncture (LP) from key informant interviews (n = 5) and a literature review. Eighteen clinician-educators from six different medical specialties were subsequently recruited as expert panellists. Over three Delphi rounds, these panellists rated: (i) their agreement with the inclusion of the simple version of the conditions in a representative ('epitome') training scenario, and (ii) how much the inverse (complex) version increases LP complexity for a novice. Cronbach's α-values were used to assess inter-rater agreement. All panellists completed Rounds 1 and 2 of the survey and 17 completed Round 3. In Round 1, Cronbach's α-values were 0.89 and 0.94 for conditions that simplify and increase LP complexity, respectively; both values increased to 0.98 in Rounds 2 and 3. With the exception of 'high CSF (cerebral spinal fluid) pressure', panellists agreed with the inclusion of all conditions in the simplest (epitome) training scenario. Panellists rated patient movement, spinal anatomy, patient cooperativeness, body habitus, and the presence or absence of an experienced assistant as having the greatest impact on the complexity of LP. This study demonstrated the feasibility of using expert consensus to establish conditions impacting the complexity of procedural skills, and the benefits of incorporating the Delphi method into the SCM. These data can be used to develop and sequence simulation scenarios in a progressively challenging manner. If the theorised learning gains associated with ET are realised, the methods described in this study may be applied to the design of simulation training for other procedural and non-procedural skills

  15. Numerical simulation of CICC design based on optimization of ratio of copper to superconductor

    International Nuclear Information System (INIS)

    Jiang Huawei; Li Yuan; Yan Shuailing

    2007-01-01

    For cable-in-conduit conductor (CICC) structure design, a numeric simulation is proposed for conductor configuration based on optimization of ratio of copper to superconductor. The simulation outcome is in agreement with engineering design one. (authors)

  16. Functional requirements for design of the Space Ultrareliable Modular Computer (SUMC) system simulator

    Science.gov (United States)

    Curran, R. T.; Hornfeck, W. A.

    1972-01-01

    The functional requirements for the design of an interpretive simulator for the space ultrareliable modular computer (SUMC) are presented. A review of applicable existing computer simulations is included along with constraints on the SUMC simulator functional design. Input requirements, output requirements, and language requirements for the simulator are discussed in terms of a SUMC configuration which may vary according to the application.

  17. Numerical design and simulation of gas turbines; Numerische Auslegung und Simulation von Gasturbinen

    Energy Technology Data Exchange (ETDEWEB)

    Schaber, R.W.

    2000-12-14

    Purpose of this thesis is the development of a universal tool for the conceptual design phase of gas turbine engines. The software concept for the tool especially for tasks in industry will be provided and examples will be shown. The Gas Turbine Simulation and Design Program GTSDP given, developed in this theses, will augment the quality of work and reduce the calculation time. In parameter studies, gas turbine designs can be easily compared with respect to component efficiencies, mass, cost, and life. [German] Ziel der Arbeit ist, unter besonderer Beachtung industrieller Aufgabenstellungen ein neues universelles Auslegungsverfahren fuer die Vorauslegung von Gasturbinen zu entwickeln, die Voraussetzungen fuer ein derartiges Programmsystem bereitzustellen und die Einsatzmoeglichkeiten an ersten Beispielen aufzuzeigen. Mit dem entwickelten Gasturbinen-Vorauslegungsprogramm GTSDP wird ein Werkzeug vorgestellt, das die Arbeitsqualitaet bei gleichzeitiger Reduzierung der Durchlaufzeiten, insbesondere durch die schnelle Vergleichbarkeit von Triebwerken hinsichtlich Wirkungsgraden, Gewicht, Kosten und Lebensdauer verbessert.

  18. Design and simulation of advanced charge recovery piezoactuator drivers

    International Nuclear Information System (INIS)

    Biancuzzi, G; Lemke, T; Woias, P; Goldschmidtboeing, F; Ruthmann, O; Schrag, H J; Vodermayer, B; Schmid, T

    2010-01-01

    The German Artificial Sphincter System project aims at the development of an implantable sphincter prosthesis driven by a piezoelectrically actuated micropump. The system has been designed to be fully implantable, i.e. the power supply is provided by a rechargeable lithium polymer battery. In order to provide sufficient battery duration and to limit battery dimensions, special effort has to be made to minimize power consumption of the whole system and, in particular, of the piezoactuator driver circuitry. Inductive charge recovery can be used to recover part of the charge stored within the actuator. We are going to present a simplified inductor-based circuit capable of voltage inversion across the actuator without the need of an additional negative voltage source. The dimension of the inductors required for such a concept is nevertheless significant. We therefore present a novel alternative concept, called direct switching, where the equivalent capacitance of the actuator is charged directly by a step-up converter and discharged by a step-down converter. We achieved superior performance compared to a simple inductor-based driver with the advantage of using small-size chip inductors. As a term of comparison, the performance of the aforementioned drivers is compared to a conventional driver that does not implement any charge recovery technique. With our design we have been able to achieve more than 50% reduction in power consumption compared to the simplest conventional driver. The new direct switching driver performs 15% better than an inductor-based driver. A novel, whole-system SPICE simulation is presented, where both the driving circuit and the piezoactuator are modeled making use of advanced nonlinear models. Such a simulation is a precious tool to design and optimize piezoactuator drivers

  19. Micro energy harvesting from ambient motion : modeling, simulation and design

    Energy Technology Data Exchange (ETDEWEB)

    Blystad, Lars-Cyril

    2012-07-01

    Vibration energy harvesting is the process of converting available ambient kinetic energy into useful electrical energy. It can be done on large scale with e.g. a wind-driven turbine. This thesis deals with small scale energy harvesters that are suitable for fabrication in Micro electromechanical Systems (MEMS) technologies. Such MEMS energy harvesters have the potential to supply power for micro power devices. Modeling, simulation and design of MEMS vibration energy harvesters are the foci of this thesis. Transduction mechanisms that are covered are electrostatic and piezoelectric. Electric equivalent circuits are obtained for the use in electromechanical simulations with the circuit simulator SPICE. The feasibility of simulating both narrow- and broadband vibrations, to model different external driving forces, in a standard circuit simulator is demonstrated. Comparisons of the har- vesters performance for different excitations are presented. A selection of passive and active power conditioning circuits is investigated and their performances compared. The active nonlinear switching conversion circuitry performs better than simple passive circuitry, especially when mechanical end stops are in effect. The active switching circuits give higher electromechanical damping, and thus can be driven at higher acceleration amplitudes before end stops are engaged. Mechanical end stops have to be present in all MEMS vibrational energy harvesters. Either due to space limitations, reliability issues, Simliberate introduction of nonlinearities or a combination of these. ulations in the thesis include mechanical end stops and thus include the corresponding nonlinearities introduced in the system. When the mechanical end stops are hit by the proof mass during high-amplitude vibrations, nonlinear effects such as saturation and jumps are present. The end stops increase the effective bandwidth at large acceleration amplitudes. End stops limit the output power for sinusoidal

  20. SIMULATION MODEL FOR DESIGN SUPPORT OF INFOCOMM REDUNDANT SYSTEMS

    Directory of Open Access Journals (Sweden)

    V. A. Bogatyrev

    2016-09-01

    Full Text Available Subject of Research. The paper deals with the effectiveness of multipath transfer of request copies through the network and their redundant service without the use of laborious analytical modeling. The model and support tools for the design of highly reliable distributed systems based on simulation modeling have been created. Method. The effectiveness of many variants of service organization and delivery through the network to the query servers is formed and analyzed. Options for providing redundant service and delivery via the network to the servers of request copies are also considered. The choice of variants for the distribution and service of requests is carried out taking into account the criticality of queries to the time of their stay in the system. The request is considered successful if at least one of its copies is accurately delivered to the working server, ready to service the request received through a network, if it is fulfilled in the set time. Efficiency analysis of the redundant transmission and service of requests is based on the model built in AnyLogic 7 simulation environment. Main Results. Simulation experiments based on the proposed models have shown the effectiveness of redundant transmission of copies of queries (packets to the servers in the cluster through multiple paths with redundant service of request copies by a group of servers in the cluster. It is shown that this solution allows increasing the probability of exact execution of at least one copy of the request within the required time. We have carried out efficiency evaluation of destruction of outdated request copies in the queues of network nodes and the cluster. We have analyzed options for network implementation of multipath transfer of request copies to the servers in the cluster over disjoint paths, possibly different according to the number of their constituent nodes. Practical Relevance. The proposed simulation models can be used when selecting the optimal

  1. Differential evolution and simulated annealing algorithms for mechanical systems design

    Directory of Open Access Journals (Sweden)

    H. Saruhan

    2014-09-01

    Full Text Available In this study, nature inspired algorithms – the Differential Evolution (DE and the Simulated Annealing (SA – are utilized to seek a global optimum solution for ball bearings link system assembly weight with constraints and mixed design variables. The Genetic Algorithm (GA and the Evolution Strategy (ES will be a reference for the examination and validation of the DE and the SA. The main purpose is to minimize the weight of an assembly system composed of a shaft and two ball bearings. Ball bearings link system is used extensively in many machinery applications. Among mechanical systems, designers pay great attention to the ball bearings link system because of its significant industrial importance. The problem is complex and a time consuming process due to mixed design variables and inequality constraints imposed on the objective function. The results showed that the DE and the SA performed and obtained convergence reliability on the global optimum solution. So the contribution of the DE and the SA application to the mechanical system design can be very useful in many real-world mechanical system design problems. Beside, the comparison confirms the effectiveness and the superiority of the DE over the others algorithms – the SA, the GA, and the ES – in terms of solution quality. The ball bearings link system assembly weight of 634,099 gr was obtained using the DE while 671,616 gr, 728213.8 gr, and 729445.5 gr were obtained using the SA, the ES, and the GA respectively.

  2. Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence.

    Science.gov (United States)

    Vo, Uybach; Vajpai, Navratna; Flavell, Liz; Bobby, Romel; Breeze, Alexander L; Embrey, Kevin J; Golovanov, Alexander P

    2016-01-22

    The activity of Ras is controlled by the interconversion between GTP- and GDP-bound forms partly regulated by the binding of the guanine nucleotide exchange factor Son of Sevenless (Sos). The details of Sos binding, leading to nucleotide exchange and subsequent dissociation of the complex, are not completely understood. Here, we used uniformly (15)N-labeled Ras as well as [(13)C]methyl-Met,Ile-labeled Sos for observing site-specific details of Ras-Sos interactions in solution. Binding of various forms of Ras (loaded with GDP and mimics of GTP or nucleotide-free) at the allosteric and catalytic sites of Sos was comprehensively characterized by monitoring signal perturbations in the NMR spectra. The overall affinity of binding between these protein variants as well as their selected functional mutants was also investigated using intrinsic fluorescence. The data support a positive feedback activation of Sos by Ras·GTP with Ras·GTP binding as a substrate for the catalytic site of activated Sos more weakly than Ras·GDP, suggesting that Sos should actively promote unidirectional GDP → GTP exchange on Ras in preference of passive homonucleotide exchange. Ras·GDP weakly binds to the catalytic but not to the allosteric site of Sos. This confirms that Ras·GDP cannot properly activate Sos at the allosteric site. The novel site-specific assay described may be useful for design of drugs aimed at perturbing Ras-Sos interactions. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  3. Fetisisme Ras Kaukasoid dan Ras Mongoloid Sebagai Strategi Pemasaran dalam Sinetron Indonesia

    Directory of Open Access Journals (Sweden)

    Dimas Yudhistira

    2014-12-01

    ABSTRAK   Budaya populer yang tumbuh seiring dengan industrialisasi memengaruhi produksi per- filman di Indonesia. Salah satu genre perfilman di Indonesia adalah sinetron. Sinetron yang di- kategorikan sebagai produk seni kitsch memiliki dua kriteria yaitu sebagai komoditi seni yang populer dan sebagai komoditi dagang yang menghasilkan keuntungan ekonomis. Sebagai se- buah produk seni kitsch yang merupakan dasar pembuatan karyanya adalah selera masyarakat kebanyakan maka sinetron harus jeli dalam melihat keadaan dan latar belakang masyarakat. Penelitian ini menggunakan metode kualitatif. Hasil penelitian ini menggambarkan masyara- kat Indonesia yang merupakan ras Melayu telah dijajah oleh ras Kaukasoid dan Mongoloid sebelum tahun 1945 dan setelahnya. Efek dari penjajahan ini adalah ras Melayu telah ditanami fantasi yang menjadi stereotip mengenai ras Kaukasoid dan Mongoloid yang berakhir dengan fetisisme. Fetisisme ini dijadikan sebagai strategi pemasaran oleh produser dan sutradara un- tuk menarik antusiasme calon penonton sinetron. Caranya dengan menampilkan aktor dan aktris Melayu keturunan Kaukasoid dan Mongoloid sebagai pemeran utama.   Kata kunci: sinetron, seni kitsch, ras, fetisisme

  4. Processing and fatty acid acylation of RAS1 and RAS2 proteins in Saccharomyces cerevisiae

    International Nuclear Information System (INIS)

    Fujiyama, A.; Tamanoi, F.

    1986-01-01

    The authors demonstrate the pathway for the biosynthesis of RAS1 and RAS2 gene products of Saccharomyces cerevisiae leading to their localization in membranes. The primary translation products of these genes are detected in a soluble fraction. Shortly after synthesis, these precursor molecules are converted to forms that migrate slightly faster than the precursor forms on a NaDodSO 4 /polyacrylamide gel. These processed proteins are further modified by fatty acid acylation, which is detected by [ 3 H]palmitic acid labeling. The acylated derivatives are found exclusively in cell membranes, indicating the translocation of the RAS proteins from cytosol to membranes during maturation process. The attached fatty acids can be released by mild alkaline hydrolysis, suggesting that the linkage between the fatty acid and the protein is an ester bond. The site of the modification by fatty acid is presumably localized to the COOH-terminal portion of the RAS proteins. Fraction of the membranes by sucrose gradient demonstrates that a majority of the fatty-acylated RAS proteins are localized in plasma membrane

  5. An Overview of the Design and Analysis of Simulation Experiments for Sensitivity Analysis

    NARCIS (Netherlands)

    Kleijnen, J.P.C.

    2004-01-01

    Sensitivity analysis may serve validation, optimization, and risk analysis of simulation models.This review surveys classic and modern designs for experiments with simulation models.Classic designs were developed for real, non-simulated systems in agriculture, engineering, etc.These designs assume a

  6. Robotic Design Choice Overview using Co-simulation and Design Space Exploration

    DEFF Research Database (Denmark)

    Christiansen, Martin Peter; Larsen, Peter Gorm; Nyholm Jørgensen, Rasmus

    2015-01-01

    . Simulations are used to evaluate the robot model output response in relation to operational demands. An example of a load carrying challenge in relation to the feeding robot is presented and a design space is defined with candidate solutions in both the mechanical and software domains. Simulation results......Rapid robotic system development has created a demand for multi-disciplinary methods and tools to explore and compare design alternatives. In this paper, we present a collaborative modelling technique that combines discrete-event models of controller software with continuous-time models of physical...... robot components. The proposed co-modelling method utilises Vienna Development Method (VDM) and Matlab for discrete-event modelling and 20-sim for continuous-time modelling. The model-based development of a mobile robot mink feeding system is used to illustrate the collaborative modelling method...

  7. Designing Crop Simulation Web Service with Service Oriented Architecture Principle

    Science.gov (United States)

    Chinnachodteeranun, R.; Hung, N. D.; Honda, K.

    2015-12-01

    Crop simulation models are efficient tools for simulating crop growth processes and yield. Running crop models requires data from various sources as well as time-consuming data processing, such as data quality checking and data formatting, before those data can be inputted to the model. It makes the use of crop modeling limited only to crop modelers. We aim to make running crop models convenient for various users so that the utilization of crop models will be expanded, which will directly improve agricultural applications. As the first step, we had developed a prototype that runs DSSAT on Web called as Tomorrow's Rice (v. 1). It predicts rice yields based on a planting date, rice's variety and soil characteristics using DSSAT crop model. A user only needs to select a planting location on the Web GUI then the system queried historical weather data from available sources and expected yield is returned. Currently, we are working on weather data connection via Sensor Observation Service (SOS) interface defined by Open Geospatial Consortium (OGC). Weather data can be automatically connected to a weather generator for generating weather scenarios for running the crop model. In order to expand these services further, we are designing a web service framework consisting of layers of web services to support compositions and executions for running crop simulations. This framework allows a third party application to call and cascade each service as it needs for data preparation and running DSSAT model using a dynamic web service mechanism. The framework has a module to manage data format conversion, which means users do not need to spend their time curating the data inputs. Dynamic linking of data sources and services are implemented using the Service Component Architecture (SCA). This agriculture web service platform demonstrates interoperability of weather data using SOS interface, convenient connections between weather data sources and weather generator, and connecting

  8. Multiphysics Modelling and Simulation for Systems Design Conference

    CERN Document Server

    Abbes, Mohamed; Choley, Jean-Yves; Boukharouba, Taoufik; Elnady, Tamer; Kanaev, Andrei; Amar, Mounir; Chaari, Fakher

    2015-01-01

    This book reports on the state of the art in the field of multiphysics systems. It consists of accurately reviewed contributions to the MMSSD’2014 conference, which was held from December 17 to 19, 2004 in Hammamet, Tunisia. The different chapters, covering new theories, methods and a number of case studies, provide readers with an up-to-date picture of multiphysics modeling and simulation. They highlight the role played by high-performance computing and newly available software in promoting the study of multiphysics coupling effects, and show how these technologies can be practically implemented to bring about significant improvements in the field of design, control and monitoring of machines.  In addition to providing a detailed description of the methods and their applications, the book also identifies new research issues, challenges and opportunities, thus providing researchers and practitioners with both technical information to support their daily work and a new source of inspiration for their future...

  9. Numerical simulation for design of biped locomotion robots

    International Nuclear Information System (INIS)

    Kume, Etsuo; Takanishi, Atsuo

    1993-01-01

    A mechanical design study of anthropomorphic walking robots for patrol and inspection in nuclear facilities is being performed at Computing and Information Systems Center (CISC) of JAERI. We mainly focus on developing a software system to find a stable walking pattern, given robot models described by links, joints and so on. One of the features of our software is that some of the body elements, such as actuators and sensors, can be modeled as material particles as well as rigid bodies. The other is that our software has the cabability of obtaining unknown part of robot motions under given part of robot motions, satisfying a stable constraint. In this paper, we present the numerical models and the simulated results. (orig.)

  10. Free elements resonator: design and simulation, application to NMR imaging

    International Nuclear Information System (INIS)

    Fakri-Bouchet, L.; Lapray, Ch.; Briquet, A.

    1999-01-01

    The free elements resonator, has a bird cage structure. It is made with purely inductively coupled circuits which are individually pre-tuned. The resonance frequency is adjusted by a simultaneous rotation of elements that preserves the coil symmetry. The radiofrequency functioning can be analysis by the usual set of coupled differential equations leading to the resonant modes. In the work presented here the formal analysis is completed by a simulation based on software (Pspice). The characteristics of each element (resistance, self-inductance, capacitance) are Firstly measured, as well as the mutual inductance between each couple of elements. Then the resonant modes and the corresponding current and voltage distribution are obtained to evaluate the radiofrequency field. Using this approach, a free elements bird-cage for efficient operation at 2 Tesla is designed. (authors)

  11. Frontiers in Planar Lightwave Circuit Technology Design, Simulation, and Fabrication

    CERN Document Server

    Janz, Siegfried; Tanev, Stoyan

    2005-01-01

    This book is the result of the NATO Advanced Research Workshop on Frontiers in Planar Lightwave Circuit Technology, which took place in Ottawa, Canada from September 21-25, 2004. Many of the world’s leading experts in integrated photonic design, theory and experiment were invited to give lectures in their fields of expertise, and participate in discussions on current research and applications, as well as the new directions planar lightwave circuit technology is evolving towards. The sum of their contributions to this book constitutes an excellent record of many key issues and scientific problems in planar lightwave circuit research at the time of writing. In this volume the reader will find detailed overviews of experimental and theoretical work in high index contrast waveguide systems, micro-optical resonators, nonlinear optics, and advanced optical simulation methods, as well as articles describing emerging applications of integrated optics for medical and biological applications.

  12. Optimized Design of Spacer in Electrodialyzer Using CFD Simulation Method

    Science.gov (United States)

    Jia, Yuxiang; Yan, Chunsheng; Chen, Lijun; Hu, Yangdong

    2018-06-01

    In this study, the effects of length-width ratio and diversion trench of the spacer on the fluid flow behavior in an electrodialyzer have been investigated through CFD simulation method. The relevant information, including the pressure drop, velocity vector distribution and shear stress distribution, demonstrates the importance of optimized design of the spacer in an electrodialysis process. The results show width of the diversion trench has a great effect on the fluid flow compared with length. Increase of the diversion trench width could strength the fluid flow, but also increase the pressure drop. Secondly, the dead zone of the fluid flow decreases with increase of length-width ratio of the spacer, but the pressure drop increases with the increase of length-width ratio of the spacer. So the appropriate length-width ratio of the space should be moderate.

  13. Experiments simulation and design to set traffic lights operation rules

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez Garcia, J.A.

    2016-07-01

    In this paper it is used the experimental design to minimize the travel time of motor vehicles, in one of the most important avenues of Celaya City in Guanajuato, Mexico, by means of optimal synchronization of existing traffic lights. In the optimization process three factors are considered: the traffic lights’ cycle times, the synchrony defined as stepped, parallel and actual, and speed limit, each one with 3 evaluation levels. The response variables to consider are: motor vehicles’ travel time, fuel consumption and greenhouse effect gas (CO2) emissions. The different experiments are performed using the simulation model developed in the PTV-VISSIM software, which represents the vehicle traffic system. The obtained results for the different proposed scenarios allow to find proper levels at which the vehicle traffic system must be operated in order to improve mobility, to reduce contamination rates and decrease the fuel consumption for the different motor vehicles that use the avenue. (Author)

  14. Colossal Tooling Design: 3D Simulation for Ergonomic Analysis

    Science.gov (United States)

    Hunter, Steve L.; Dischinger, Charles; Thomas, Robert E.; Babai, Majid

    2003-01-01

    The application of high-level 3D simulation software to the design phase of colossal mandrel tooling for composite aerospace fuel tanks was accomplished to discover and resolve safety and human engineering problems. The analyses were conducted to determine safety, ergonomic and human engineering aspects of the disassembly process of the fuel tank composite shell mandrel. Three-dimensional graphics high-level software, incorporating various ergonomic analysis algorithms, was utilized to determine if the process was within safety and health boundaries for the workers carrying out these tasks. In addition, the graphical software was extremely helpful in the identification of material handling equipment and devices for the mandrel tooling assembly/disassembly process.

  15. Carbon dioxide capture processes: Simulation, design and sensitivity analysis

    DEFF Research Database (Denmark)

    Zaman, Muhammad; Lee, Jay Hyung; Gani, Rafiqul

    2012-01-01

    equilibrium and associated property models are used. Simulations are performed to investigate the sensitivity of the process variables to change in the design variables including process inputs and disturbances in the property model parameters. Results of the sensitivity analysis on the steady state...... performance of the process to the L/G ratio to the absorber, CO2 lean solvent loadings, and striper pressure are presented in this paper. Based on the sensitivity analysis process optimization problems have been defined and solved and, a preliminary control structure selection has been made.......Carbon dioxide is the main greenhouse gas and its major source is combustion of fossil fuels for power generation. The objective of this study is to carry out the steady-state sensitivity analysis for chemical absorption of carbon dioxide capture from flue gas using monoethanolamine solvent. First...

  16. FinFET modeling for IC simulation and design

    CERN Document Server

    Hu, Chenming; Lu, Darsen D

    2015-01-01

    This book is the first to explain FinFET modeling for IC simulation and the industry standard - BSIM-CMG - describing the rush in demand for advancing the technology from planar to 3D architecture, as now enabled by the approved industry standard. The book gives a strong foundation on the physics and operation of FinFET, details aspects of the BSIM-CMG model such as surface potential, charge and current calculations, and includes a dedicated chapter on parameter extraction procedures, providing a step-by-step approach for the efficient extraction of model parameters. With this book you will learn: * Why you should use FinFET* The physics and operation of FinFET* Details of the FinFET standard model (BSIM-CMG)* Parameter extraction in BSIM-CMG* FinFET circuit design and simulation * Authored by the lead inventor and developer of FinFET, and developers of the BSIM-CM standard model, providing an experts' insight into the specifications of the standard* The first book on the industry-standard FinFET model - BSIM...

  17. Constraining continuous rainfall simulations for derived design flood estimation

    Science.gov (United States)

    Woldemeskel, F. M.; Sharma, A.; Mehrotra, R.; Westra, S.

    2016-11-01

    Stochastic rainfall generation is important for a range of hydrologic and water resources applications. Stochastic rainfall can be generated using a number of models; however, preserving relevant attributes of the observed rainfall-including rainfall occurrence, variability and the magnitude of extremes-continues to be difficult. This paper develops an approach to constrain stochastically generated rainfall with an aim of preserving the intensity-durationfrequency (IFD) relationships of the observed data. Two main steps are involved. First, the generated annual maximum rainfall is corrected recursively by matching the generated intensity-frequency relationships to the target (observed) relationships. Second, the remaining (non-annual maximum) rainfall is rescaled such that the mass balance of the generated rain before and after scaling is maintained. The recursive correction is performed at selected storm durations to minimise the dependence between annual maximum values of higher and lower durations for the same year. This ensures that the resulting sequences remain true to the observed rainfall as well as represent the design extremes that may have been developed separately and are needed for compliance reasons. The method is tested on simulated 6 min rainfall series across five Australian stations with different climatic characteristics. The results suggest that the annual maximum and the IFD relationships are well reproduced after constraining the simulated rainfall. While our presentation focusses on the representation of design rainfall attributes (IFDs), the proposed approach can also be easily extended to constrain other attributes of the generated rainfall, providing an effective platform for post-processing of stochastic rainfall generators.

  18. Design, simulation and construction of the Taban tokamak

    Science.gov (United States)

    H, R. MIRZAEI; R, AMROLLAHI

    2018-04-01

    This paper describes the design and construction of the Taban tokamak, which is located in Amirkabir University of Technology, Tehran, Iran. The Taban tokamak was designed for plasma investigation. The design, simulation and construction of essential parts of the Taban tokamak such as the toroidal field (TF) system, ohmic heating (OH) system and equilibrium field system and their power supplies are presented. For the Taban tokamak, the toroidal magnetic coil was designed to produce a maximum field of 0.7 T at R = 0.45 m. The power supply of the TF was a 130 kJ, 0–10 kV capacitor bank. Ripples of toroidal magnetic field at the plasma edge and plasma center are 0.2% and 0.014%, respectively. For the OH system with 3 kA current, the stray field in the plasma region is less than 40 G over 80% of the plasma volume. The power supply of the OH system consists of two stages, as follows. The fast bank stage is a 120 μF, 0–5 kV capacitor that produces 2.5 kA in 400 μs and the slow bank stage is 93 mF, 600 V that can produce a maximum of 3 kA. The equilibrium system can produce uniform magnetic field at plasma volume. This system’s power supply, like the OH system, consists of two stages, so that the fast bank stage is 500 μF, 800 V and the slow bank stage is 110 mF, 200 V.

  19. Software for simulation of a computed tomography imaging spectrometer using optical design software

    Science.gov (United States)

    Spuhler, Peter T.; Willer, Mark R.; Volin, Curtis E.; Descour, Michael R.; Dereniak, Eustace L.

    2000-11-01

    Our Imaging Spectrometer Simulation Software known under the name Eikon should improve and speed up the design of a Computed Tomography Imaging Spectrometer (CTIS). Eikon uses existing raytracing software to simulate a virtual instrument. Eikon enables designers to virtually run through the design, calibration and data acquisition, saving significant cost and time when designing an instrument. We anticipate that Eikon simulations will improve future designs of CTIS by allowing engineers to explore more instrument options.

  20. Numerical simulation for the design analysis of kinematic Stirling engines

    International Nuclear Information System (INIS)

    Araoz, Joseph A.; Salomon, Marianne; Alejo, Lucio; Fransson, Torsten H.

    2015-01-01

    simulation allowed to evaluate the effect that different design and operational parameters have on the engine performance, and consequently different performance curves were obtained. These curves allowed to identify ranges for the charged pressure, temperature ratio, heat exchangers dimensions, crank phase angle and crank mechanical effectiveness, where the engine performance was improved. In addition, the curves also permitted to recognise ranges were the design parameters could drastically reduce the brake power and efficiency. The results also showed that the design of the engine is affected by the conditions imposed by the CHP interactions, and that the engine could reach a brake power closer to 832 W with a corresponding brake efficiency of 26% when the adequate design parameters were considered. On the other hand, the performance could also be very low; as the reported in experimental tests, with brake power measurements ranging 52–120 W.

  1. Bacillus subtilis Intramembrane Protease RasP Activity in Escherichia coli and In Vitro.

    Science.gov (United States)

    Parrell, Daniel; Zhang, Yang; Olenic, Sandra; Kroos, Lee

    2017-10-01

    RasP is a predicted intramembrane metalloprotease of Bacillus subtilis that has been proposed to cleave the stress response anti-sigma factors RsiW and RsiV, the cell division protein FtsL, and remnant signal peptides within their transmembrane segments. To provide evidence for direct effects of RasP on putative substrates, we developed a heterologous coexpression system. Since expression of catalytically inactive RasP E21A inhibited expression of other membrane proteins in Escherichia coli , we added extra transmembrane segments to RasP E21A, which allowed accumulation of most other membrane proteins. A corresponding active version of RasP appeared to promiscuously cleave coexpressed membrane proteins, except those with a large periplasmic domain. However, stable cleavage products were not observed, even in clpP mutant E. coli Fusions of transmembrane segment-containing parts of FtsL and RsiW to E. coli maltose-binding protein (MBP) also resulted in proteins that appeared to be RasP substrates upon coexpression in E. coli , including FtsL with a full-length C-terminal domain (suggesting that prior cleavage by a site 1 protease is unnecessary) and RsiW designed to mimic the PrsW site 1 cleavage product (suggesting that further trimming by extracytoplasmic protease is unnecessary). Purified RasP cleaved His 6 -MBP-RsiW(73-118) in vitro within the RsiW transmembrane segment based on mass spectrometry analysis, demonstrating that RasP is an intramembrane protease. Surprisingly, purified RasP failed to cleave His 6 -MBP-FtsL(23-117). We propose that the lack of α-helix-breaking residues in the FtsL transmembrane segment creates a requirement for the membrane environment and/or an additional protein(s) in order for RasP to cleave FtsL. IMPORTANCE Intramembrane proteases govern important signaling pathways in nearly all organisms. In bacteria, they function in stress responses, cell division, pathogenesis, and other processes. Their membrane-associated substrates are

  2. A calculation method for RF couplers design based on numerical simulation by microwave studio

    International Nuclear Information System (INIS)

    Wang Rong; Pei Yuanji; Jin Kai

    2006-01-01

    A numerical simulation method for coupler design is proposed. It is based on the matching procedure for the 2π/3 structure given by Dr. R.L. Kyhl. Microwave Studio EigenMode Solver is used for such numerical simulation. the simulation for a coupler has been finished with this method and the simulation data are compared with experimental measurements. The results show that this numerical simulation method is feasible for coupler design. (authors)

  3. Tornado missile simulation and design methodology. Volume 1: simulation methodology, design applications, and TORMIS computer code. Final report

    International Nuclear Information System (INIS)

    Twisdale, L.A.; Dunn, W.L.

    1981-08-01

    A probabilistic methodology has been developed to predict the probabilities of tornado-propelled missiles impacting and damaging nuclear power plant structures. Mathematical models of each event in the tornado missile hazard have been developed and sequenced to form an integrated, time-history simulation methodology. The models are data based where feasible. The data include documented records of tornado occurrence, field observations of missile transport, results of wind tunnel experiments, and missile impact tests. Probabilistic Monte Carlo techniques are used to estimate the risk probabilities. The methodology has been encoded in the TORMIS computer code to facilitate numerical analysis and plant-specific tornado missile probability assessments. Sensitivity analyses have been performed on both the individual models and the integrated methodology, and risk has been assessed for a hypothetical nuclear power plant design case study

  4. Positional glow curve simulation for thermoluminescent detector (TLD) system design

    International Nuclear Information System (INIS)

    Branch, C.J.; Kearfott, K.J.

    1999-01-01

    Multi- and thin element dosimeters, variable heating rate schemes, and glow-curve analysis have been employed to improve environmental and personnel dosimetry using thermoluminescent detectors (TLDs). Detailed analysis of the effects of errors and optimization of techniques would be highly desirable. However, an understanding of the relationship between TL light production, light attenuation, and precise heating schemes is made difficult because of experimental challenges involved in measuring positional TL light production and temperature variations as a function of time. This work reports the development of a general-purpose computer code, thermoluminescent detector simulator, TLD-SIM, to simulate the heating of any TLD type using a variety of conventional and experimental heating methods including pulsed focused or unfocused lasers with Gaussian or uniform cross sections, planchet, hot gas, hot finger, optical, infrared, or electrical heating. TLD-SIM has been used to study the impact on the TL light production of varying the input parameters which include: detector composition, heat capacity, heat conductivity, physical size, and density; trapped electron density, the frequency factor of oscillation of electrons in the traps, and trap-conduction band potential energy difference; heating scheme source terms and heat transfer boundary conditions; and TL light scatter and attenuation coefficients. Temperature profiles and glow curves as a function of position time, as well as the corresponding temporally and/or spatially integrated glow values, may be plotted while varying any of the input parameters. Examples illustrating TLD system functions, including glow curve variability, will be presented. The flexible capabilities of TLD-SIM promises to enable improved TLD system design

  5. Variational data assimilation system "INM RAS - Black Sea"

    Science.gov (United States)

    Parmuzin, Eugene; Agoshkov, Valery; Assovskiy, Maksim; Giniatulin, Sergey; Zakharova, Natalia; Kuimov, Grigory; Fomin, Vladimir

    2013-04-01

    Development of Informational-Computational Systems (ICS) for Data Assimilation Procedures is one of multidisciplinary problems. To study and solve these problems one needs to apply modern results from different disciplines and recent developments in: mathematical modeling; theory of adjoint equations and optimal control; inverse problems; numerical methods theory; numerical algebra and scientific computing. The problems discussed above are studied in the Institute of Numerical Mathematics of the Russian Academy of Science (INM RAS) in ICS for Personal Computers (PC). Special problems and questions arise while effective ICS versions for PC are being developed. These problems and questions can be solved with applying modern methods of numerical mathematics and by solving "parallelism problem" using OpenMP technology and special linear algebra packages. In this work the results on the ICS development for PC-ICS "INM RAS - Black Sea" are presented. In the work the following problems and questions are discussed: practical problems that can be studied by ICS; parallelism problems and their solutions with applying of OpenMP technology and the linear algebra packages used in ICS "INM - Black Sea"; Interface of ICS. The results of ICS "INM RAS - Black Sea" testing are presented. Efficiency of technologies and methods applied are discussed. The work was supported by RFBR, grants No. 13-01-00753, 13-05-00715 and by The Ministry of education and science of Russian Federation, project 8291, project 11.519.11.1005 References: [1] V.I. Agoshkov, M.V. Assovskii, S.A. Lebedev, Numerical simulation of Black Sea hydrothermodynamics taking into account tide-forming forces. Russ. J. Numer. Anal. Math. Modelling (2012) 27, No.1, 5-31 [2] E.I. Parmuzin, V.I. Agoshkov, Numerical solution of the variational assimilation problem for sea surface temperature in the model of the Black Sea dynamics. Russ. J. Numer. Anal. Math. Modelling (2012) 27, No.1, 69-94 [3] V.B. Zalesny, N.A. Diansky, V

  6. Intraocular Telescopic System Design: Optical and Visual Simulation in a Human Eye Model

    OpenAIRE

    Zoulinakis, Georgios; Ferrer-Blasco, Teresa

    2017-01-01

    Purpose. To design an intraocular telescopic system (ITS) for magnifying retinal image and to simulate its optical and visual performance after implantation in a human eye model. Methods. Design and simulation were carried out with a ray-tracing and optical design software. Two different ITS were designed, and their visual performance was simulated using the Liou-Brennan eye model. The difference between the ITS was their lenses’ placement in the eye model and their powers. Ray tracing in bot...

  7. fpga controller design and simulation of a portable dough mixing

    African Journals Online (AJOL)

    modelled and simulated with Matlab/Simulink. Synthesizable VHDL ... Keywords: FPGA, VHDL, PID controller, Pulse Width Modulation, Full H-Bridge DC motor driver. 1. ... and (b) to simulate the control process in a virtual environment, using.

  8. Easy simulation and design of on-chip inductors in standard CMOS processes

    DEFF Research Database (Denmark)

    Christensen, Kåre Tais; Jørgensen, Allan

    1998-01-01

    This paper presents an approach to CMOS inductor modelling, that allow easy simulation in SPICE-like simulators. A number of test results are presented concerning optimal center hole, inductor area, wire spacing and self-inductance. Finally a comprehensive design guide is provided on how to design...... close-to-optimal inductors without the use of electromagnetic simulators...

  9. A Ten-Step Design Method for Simulation Games in Logistics Management

    NARCIS (Netherlands)

    Fumarola, M.; Van Staalduinen, J.P.; Verbraeck, A.

    2011-01-01

    Simulation games have often been found useful as a method of inquiry to gain insight in complex system behavior and as aids for design, engineering simulation and visualization, and education. Designing simulation games are the result of creative thinking and planning, but often not the result of a

  10. Intuitive thinking of design and redesign on innovative aircraft cabin simulator

    NARCIS (Netherlands)

    Tan, C.F.; Chen, W.; Rauterberg, G.W.M.

    2009-01-01

    In this paper, the intuition approach in the design and redesign of the environmental friendly innovative aircraft cabin simulator is presented. The simulator is a testbed that was designed and built for research on aircraft passenger comfort improvement of long haul air travel. The simulation

  11. RAS III - concept and operating experience

    International Nuclear Information System (INIS)

    Kunze, U.; Wander, J.

    1990-01-01

    A new noise analysis system RAS III is being employed at the Greifswald NPP 'Bruno Leuschner' units 5 and 6 which differs from its forerunner types by an extended number of measuring points and a higher degree of automation. Substantial prerequisite of the system's full efficiency is implementation of efficient signal monitoring techniques that free the power plant engineer from routine work as well. The system has therefore been completed by algorithms established for automatic noise signal spectra control and for monitoring the pressure vessel vibrations. Moreover, a number of special techniques have been developed, such as for recording velocity-time plots during control element drop experiments. (author)

  12. Effects of Thinking Style on Design Strategies: Using Bridge Construction Simulation Programs

    Science.gov (United States)

    Sun, Chuen-Tsai; Wang, Dai-Yi; Chang, Yu-Yeh

    2013-01-01

    Computer simulation users can freely control operational factors and simulation results, repeat processes, make changes, and learn from simulation environment feedback. The focus of this paper is on simulation-based design tools and their effects on student learning processes in a group of 101 Taiwanese senior high school students. Participants…

  13. Design of simulation-based medical education and advantages and disadvantages of in situ simulation versus off-site simulation

    DEFF Research Database (Denmark)

    Sørensen, Jette Led; Østergaard, Doris; LeBlanc, Vicki

    2017-01-01

    that choice of setting for simulations does not seem to influence individual and team learning. Department-based local simulation, such as simulation in-house and especially in situ simulation, leads to gains in organisational learning. The overall objectives of simulation-based education and factors......BACKGROUND: Simulation-based medical education (SBME) has traditionally been conducted as off-site simulation in simulation centres. Some hospital departments also provide off-site simulation using in-house training room(s) set up for simulation away from the clinical setting, and these activities...... simulations. DISCUSSION: Non-randomised studies argue that in situ simulation is more effective for educational purposes than other types of simulation settings. Conversely, the few comparison studies that exist, either randomised or retrospective, show that choice of setting does not seem to influence...

  14. NDDP multi-stage flash desalination process simulator design

    International Nuclear Information System (INIS)

    Chatterjee, M.; Sashi Kumar, G.N.; Mahendra, A.K.; Sanyal, A.; Gouthaman, G.

    2006-05-01

    A majority of large-scale desalination plants all over the world employ multi-stage flash (MSF) distillation process. Many of these MSF desalination plants have been set up near to nuclear power plants (generally called as nuclear desalination plants) to effectively utilize the low-grade steam from the power plants as the source of energy. A computer program called MSFSIM has been developed to simulate the MSF desalination plant operation both for steady state and various transients including start up. This code predicts the effect of number of stages, flashing temperature, velocity of brine flowing through the tubes of brine heater and evaporators, temperature of the condensing thin film etc. on the plant performance ratio. Such a code can be used for the design of a new plant and to predict its operating and startup characteristics. The code has been extensively validated with available start up data from the pilot MSF desalination plant of 425-m3/day capacity at Trombay, Mumbai. A MSF desalination plant of 4500-m3/day capacity is under construction by BARC at Kalpakkam, which will utilize the steam from Madras Atomic Power Station (MAPS). In this present work extensive parametric study of the 4500-m3/day capacity desalination plant at Kalpakkam has been done using the code MSFSIM for optimizing the operating parameters in order to maximize the performance ratio for stable plant operation. The aim of the work is prediction of plant performance under different operating conditions. (author)

  15. Simulation-based optimal Bayesian experimental design for nonlinear systems

    KAUST Repository

    Huan, Xun

    2013-01-01

    The optimal selection of experimental conditions is essential to maximizing the value of data for inference and prediction, particularly in situations where experiments are time-consuming and expensive to conduct. We propose a general mathematical framework and an algorithmic approach for optimal experimental design with nonlinear simulation-based models; in particular, we focus on finding sets of experiments that provide the most information about targeted sets of parameters.Our framework employs a Bayesian statistical setting, which provides a foundation for inference from noisy, indirect, and incomplete data, and a natural mechanism for incorporating heterogeneous sources of information. An objective function is constructed from information theoretic measures, reflecting expected information gain from proposed combinations of experiments. Polynomial chaos approximations and a two-stage Monte Carlo sampling method are used to evaluate the expected information gain. Stochastic approximation algorithms are then used to make optimization feasible in computationally intensive and high-dimensional settings. These algorithms are demonstrated on model problems and on nonlinear parameter inference problems arising in detailed combustion kinetics. © 2012 Elsevier Inc.

  16. New cellular automaton designed to simulate geometration in gel electrophoresis

    Science.gov (United States)

    Krawczyk, M. J.; Kułakowski, K.; Maksymowicz, A. Z.

    2002-08-01

    We propose a new kind of cellular automaton to simulate transportation of molecules of DNA through agarose gel. Two processes are taken into account: reptation at strong electric field E, described in the particle model, and geometration, i.e. subsequent hookings and releases of long molecules at and from gel fibres. The automaton rules are deterministic and they are designed to describe both processes within one unified approach. Thermal fluctuations are not taken into account. The number of simultaneous hookings is limited by the molecule length. The features of the automaton are: (i) the size of the cell neighbourhood for the automaton rule varies dynamically, from nearest neighbors to the entire molecule; (ii) the length of the time step is determined at each step according to dynamic rules. Calculations are made up to N=244 reptons in a molecule. Two subsequent stages of the motion are found. Firstly, an initial set of random configurations of molecules is transformed into a more ordered phase, where most molecules are elongated along the applied field direction. After some transient time, the mobility μ reaches a constant value. Then, it varies with N as 1/ N for long molecules. The band dispersion varies with time t approximately as Nt1/2. Our results indicate that the well-known plateau of the mobility μ vs. N does not hold at large electric fields.

  17. Design and Simulation of Low Power 2 Gbps LVDS Driver

    CERN Document Server

    2015-01-01

    A monolithic active pixel sensor developed in the TowerJazz 180 nm CMOS imaging Sensor process will equip the upgraded ALICE Inner Tracking System after the Long Shutdown 2 in 2019. To limit the material budget, the power consumption of the pixel chip should be below 100 mW/cm2. The pixel sensor chip data is transmitted by a High speed Low Voltage Differential Signaling (LVDS) driver. It is responsible to deliver the signal to the transmission line with high quality (minimum jitter and wide eye diagram opening). The present LVDS driver is one of the most power hungry circuits in the sensor. For this reason a detailed study has been carried out to target a lower power consumption. This report presents the design and simulation of a Low Voltage Differential Signaling (LVDS) driver based on the H-bridge scheme driving a 4 mA current on a 100 Ω termination resistor. Since the 4 mA always flows in one of the two branches, while the other branch is “off”, the static power consumption is power is represented by...

  18. Design of simulation-based medical education and advantages and disadvantages of in situ simulation versus off-site simulation

    NARCIS (Netherlands)

    Sorensen, J.L.; Ostergaard, D.; Leblanc, V.; Ottesen, B.; Konge, L.; Dieckmann, P.; Vleuten, C. van der

    2017-01-01

    BACKGROUND: Simulation-based medical education (SBME) has traditionally been conducted as off-site simulation in simulation centres. Some hospital departments also provide off-site simulation using in-house training room(s) set up for simulation away from the clinical setting, and these activities

  19. Design, simulation and construction of the GERDA-muon veto; Design, Simulation und Aufbau des GERDA-Myonvetos

    Energy Technology Data Exchange (ETDEWEB)

    Knapp, Markus Alexander

    2009-10-09

    The GERmanium Detector Array (Gerda) is a experiment searching for the neutrinoless double beta decay of {sup 76}Ge. This very rare weakly interacting process is predicted to occur if the neutrino exhibits a mass and is a Majorana particle; i.e. it is its own antiparticle. Although the double beta decay with emission of two neutrinos has been found in several nuclei, there is at this moment only a part of the Heidelberg-Moscow Collaboration claiming to have observed the neutrinoless double beta decay. The best limit for the half life currently is T{sub 1/2} > 1.2.10{sup 25} y. Gerda will expose about 15 kg.y of enriched germanium detectors from the Heidelberg-Moscow and IGEX crystals in phase I. In this phase, it will be able to test the claim within one year, due to reduced background by a factor 10. In phase II about 100 kg.y of data will be accumulated, leading to T{sub 1/2} > 2.10{sup 26} y due to an additional reduction of the background by a factor of 10. For a high sensitivity at these half lives, it is necessary to detect the corresponding rare events. Therefore background reduction to a rate of 10{sup -3} (counts)/(keV.kg.year) is of utmost importance. Therefore different background identification methods, like pulseshape analysis or a muon veto will be used. In this work, the development of the Cherenkov muon veto detectors is presented. First design studies will be shown, including extensive Monte-Carlo simulations. These simulations were also used to optimize the trigger conditions of the data acquisition, to detect all muons, that cause an energy deposition in the germanium detectors. Finally the on site construction at the Laboratori Nazionali del Gran Sasso in Italy will be described. (orig.)

  20. Exploring environmental causes of altered ras effects: fragmentation plus integration?

    Science.gov (United States)

    Porta, Miquel; Ayude, Daniel; Alguacil, Juan; Jariod, Manuel

    2003-02-01

    Mutations in ras genes are the most common abnormality of oncogenes in human cancer and a major example of activation by point mutation. Experimental and epidemiological studies support the notion that Ki-ras activation and expression may be chemically related. We discuss the potential role of several environmental compounds in the induction or promotion of ras mutations in humans, with a focus on exocrine pancreatic cancer, the human tumor with the highest prevalence at diagnosis of Ki-ras mutations. Organochlorine compounds, organic solvents, and coffee compounds may play an indirect role in causing Ki-ras mutations, rather than as direct inducers of the mutations. Although for some organochlorine compounds the induction of point mutations in ras oncogenes cannot be excluded, it seems more likely that the effects of these compounds are mediated through nongenomic or indirectly genotoxic mechanisms of action. Organic solvents also may act via enzymatic induction of ras mutagens or by providing a proliferation advantage to ras-mutated cell clones. In exocrine pancreatic cancer, caffeine, other coffee compounds, or other factors with which coffee drinking is associated could modulate Ki-ras activation by interfering with DNA repair, cell-cycle checkpoints, and apoptosis. Asbestos, cigarette smoking, and some dietary factors also may be involved in the initiation or the promotion of Ki-ras mutations in lung and colon cancers. Further development of the mechanistic scenarios proposed here could contribute to a meaningful integration of biological, clinical, and environmental knowledge on the causes of altered ras effects. Copyright 2003 Wiley-Liss, Inc.

  1. Ras and Rheb Signaling in Survival and Cell Death

    International Nuclear Information System (INIS)

    Ehrkamp, Anja; Herrmann, Christian; Stoll, Raphael; Heumann, Rolf

    2013-01-01

    One of the most obvious hallmarks of cancer is uncontrolled proliferation of cells partly due to independence of growth factor supply. A major component of mitogenic signaling is Ras, a small GTPase. It was the first identified human protooncogene and is known since more than three decades to promote cellular proliferation and growth. Ras was shown to support growth factor-independent survival during development and to protect from chemical or mechanical lesion-induced neuronal degeneration in postmitotic neurons. In contrast, for specific patho-physiological cases and cellular systems it has been shown that Ras may also promote cell death. Proteins from the Ras association family (Rassf, especially Rassf1 and Rassf5) are tumor suppressors that are activated by Ras-GTP, triggering apoptosis via e.g., activation of mammalian sterile 20-like (MST1) kinase. In contrast to Ras, their expression is suppressed in many types of tumours, which makes Rassf proteins an exciting model for understanding the divergent effects of Ras activity. It seems likely that the outcome of Ras signaling depends on the balance between the activation of its various downstream effectors, thus determining cellular fate towards either proliferation or apoptosis. Ras homologue enriched in brain (Rheb) is a protein from the Ras superfamily that is also known to promote proliferation, growth, and regeneration through the mammalian target of rapamycin (mTor) pathway. However, recent evidences indicate that the Rheb-mTor pathway may switch its function from a pro-growth into a cell death pathway, depending on the cellular situation. In contrast to Ras signaling, for Rheb, the cellular context is likely to modulate the whole Rheb-mTor pathway towards cellular death or survival, respectively

  2. Ras and Rheb Signaling in Survival and Cell Death

    Energy Technology Data Exchange (ETDEWEB)

    Ehrkamp, Anja [Molecular Neurobiochemistry, Ruhr University of Bochum, 44780 Bochum (Germany); Herrmann, Christian [Department of Physical Chemistry1, Protein Interaction, Ruhr University of Bochum, 44780 Bochum (Germany); Stoll, Raphael [Biomolecular NMR, Ruhr University of Bochum, 44780 Bochum (Germany); Heumann, Rolf, E-mail: rolf.heumann@rub.de [Molecular Neurobiochemistry, Ruhr University of Bochum, 44780 Bochum (Germany)

    2013-05-28

    One of the most obvious hallmarks of cancer is uncontrolled proliferation of cells partly due to independence of growth factor supply. A major component of mitogenic signaling is Ras, a small GTPase. It was the first identified human protooncogene and is known since more than three decades to promote cellular proliferation and growth. Ras was shown to support growth factor-independent survival during development and to protect from chemical or mechanical lesion-induced neuronal degeneration in postmitotic neurons. In contrast, for specific patho-physiological cases and cellular systems it has been shown that Ras may also promote cell death. Proteins from the Ras association family (Rassf, especially Rassf1 and Rassf5) are tumor suppressors that are activated by Ras-GTP, triggering apoptosis via e.g., activation of mammalian sterile 20-like (MST1) kinase. In contrast to Ras, their expression is suppressed in many types of tumours, which makes Rassf proteins an exciting model for understanding the divergent effects of Ras activity. It seems likely that the outcome of Ras signaling depends on the balance between the activation of its various downstream effectors, thus determining cellular fate towards either proliferation or apoptosis. Ras homologue enriched in brain (Rheb) is a protein from the Ras superfamily that is also known to promote proliferation, growth, and regeneration through the mammalian target of rapamycin (mTor) pathway. However, recent evidences indicate that the Rheb-mTor pathway may switch its function from a pro-growth into a cell death pathway, depending on the cellular situation. In contrast to Ras signaling, for Rheb, the cellular context is likely to modulate the whole Rheb-mTor pathway towards cellular death or survival, respectively.

  3. The Role of Conserved Waters in Conformational Transitions of Q61H K-ras

    Science.gov (United States)

    Prakash, Priyanka; Sayyed-Ahmad, Abdallah; Gorfe, Alemayehu A.

    2012-01-01

    To investigate the stability and functional role of long-residence water molecules in the Q61H variant of the signaling protein K-ras, we analyzed all available Ras crystal structures and conformers derived from a series of independent explicit solvent molecular dynamics (MD) simulations totaling 1.76 µs. We show that the protein samples a different region of phase space in the presence and absence of several crystallographically conserved and buried water molecules. The dynamics of these waters is coupled with the local as well as the global motions of the protein, in contrast to less buried waters whose exchange with bulk is only loosely coupled with the motion of loops in their vicinity. Aided by two novel reaction coordinates involving the distance (d) between the Cα atoms of G60 at switch 2 and G10 at the P-loop and the N-Cα-C-O dihedral (ξ) of G60, we further show that three water molecules located in lobe1, at the interface between the lobes and at lobe2, are involved in the relative motion of residues at the two lobes of Q61H K-ras. Moreover, a d/ξ plot classifies the available Ras x-ray structures and MD-derived K-ras conformers into active GTP-, intermediate GTP-, inactive GDP-bound, and nucleotide-free conformational states. The population of these states and the transition between them is modulated by water-mediated correlated motions involving the functionally critical switch 2, P-loop and helix 3. These results suggest that water molecules act as allosteric ligands to induce a population shift among distinct switch 2 conformations that differ in effector recognition. PMID:22359497

  4. Gas-grain simulation experiment module conceptual design and gas-grain simulation facility breadboard development

    Science.gov (United States)

    Zamel, James M.; Petach, Michael; Gat, Nahum; Kropp, Jack; Luong, Christina; Wolff, Michael

    1993-12-01

    This report delineates the Option portion of the Phase A Gas-Grain Simulation Facility study. The conceptual design of a Gas-Grain Simulation Experiment Module (GGSEM) for Space Shuttle Middeck is discussed. In addition, a laboratory breadboard was developed during this study to develop a key function for the GGSEM and the GGSF, specifically, a solid particle cloud generating device. The breadboard design and test results are discussed and recommendations for further studies are included. The GGSEM is intended to fly on board a low earth orbit (LEO), manned platform. It will be used to perform a subset of the experiments planned for the GGSF for Space Station Freedom, as it can partially accommodate a number of the science experiments. The outcome of the experiments performed will provide an increased understanding of the operational requirements for the GGSF. The GGSEM will also act as a platform to accomplish technology development and proof-of-principle experiments for GGSF hardware, and to verify concepts and designs of hardware for GGSF. The GGSEM will allow assembled subsystems to be tested to verify facility level operation. The technology development that can be accommodated by the GGSEM includes: GGSF sample generation techniques, GGSF on-line diagnostics techniques, sample collection techniques, performance of various types of sensors for environmental monitoring, and some off-line diagnostics. Advantages and disadvantages of several LEO platforms available for GGSEM applications are identified and discussed. Several of the anticipated GGSF experiments require the de-agglomeration and dispensing of dry solid particles into an experiment chamber. During the GGSF Phase A study, various techniques and devices available for the solid particle aerosol generator were reviewed. As a result of this review, solid particle de-agglomeration and dispensing were identified as key undeveloped technologies in the GGSF design. A laboratory breadboard version of a solid

  5. Design of subjects training on reactor simulator and feasibility study - toward the empirical evaluation of interface design concept

    International Nuclear Information System (INIS)

    Yamaguchi, Y.; Furukawa, H.; Tanabe, F.

    1998-01-01

    On-going JAERI's project for empirical evaluation of the ecological interface design concept was first described. The empirical evaluation is planned to be proceeded through three consecutive steps; designing and actual implementation of the interface on reactor simulator, verification of the interface created, and the validation by the simulator experiment. For conducting the project, three different experimental resources are prerequisite, that are, data analysis method for identifying the operator's strategies, experimental facility including reactor simulator, and experimental subjects or subjects training method. Among the three experimental resources, subjects training method was recently designed and a simulator experiment was earned out in order to examine the feasibility of the designed training method. From the experiment and analysis of the experimental records, we could conclude that it is feasible that the experimental subjects having an appropriate technical basis can gain the sufficient competence for evaluation work of the interface design concept by using the training method designed. (author)

  6. Application of HEC-RAS for flood forecasting in perched river-A case study of hilly region, China

    Science.gov (United States)

    Sun, Pingping; Wang, Shuqian; Gan, Hong; Liu, Bin; Jia, Ling

    2017-04-01

    Flooding in small and medium rivers are seriously threatening the safety of human beings’ life and property. The simulation forecasting of the river flood and bank risk in hilly region has gradually become a hotspot. At present, there are few studies on the simulation of hilly perched river, especially in the case of lacking section flow data. And the method of how to determine the position of the levee breach along the river bank is not much enough. Based on the characteristics of the sections in hilly perched river, an attempt is applied in this paper which establishes the correlation between the flow profile computed by HEC-RAS model and the river bank. A hilly perched river in Lingshi County, Shanxi Province of China, is taken as the study object, the levee breach positions along the bank are simulated under four different design storm. The results show that the flood control standard of upper reach is high, which can withstand the design storm of 100 years. The current standard of lower reach is low, which is the flooding channel with high frequency. As the standard of current channel between the 2rd and the 11th section is low, levee along that channel of the river bank is considered to be heighten and reinforced. The study results can provide some technical support for flood proofing in hilly region and some reference for the reinforcement of river bank.

  7. Model of Ciliwung River Flood Diversion Tunnel Using HEC-RAS Software

    Directory of Open Access Journals (Sweden)

    Nugroho Joko

    2018-01-01

    Full Text Available As a coastal city which lies in lowland area, Jakarta is prone to flooding. One major river which flow through Jakarta is Ciliwung River. There are alternatives to reduce flood risk, such as: river capacity improvement, existing natural reservoir and polder system improvement, upstream reservoir construction, city drainage improvement, flood channel construction and flood diversion. This paper presents capacity analysis of a proposed flood diversion of Ciliwung River to Cipinang River. Cipinang River has its downstream end at Eastern Flood Canal (Kanal Banjir Timur, KBT. This diversion is based on the available capacity of KBT. A 1-D numerical hydraulic model using HEC-RAS based on a proposed design is used to assess the performance of the diversion system in any combination of upstream and downstream boundary condition. Simulations were done for steady condition. The results show that capacity of the system can be achieved for certain condition at upstream and downstream boundary. The effects at the downstream reach of Ciliwung and Cipinang River due to the diversion are also obtained.

  8. Rapidly Re-Configurable Flight Simulator Tools for Crew Vehicle Integration Research and Design

    Science.gov (United States)

    Pritchett, Amy R.

    2002-01-01

    While simulation is a valuable research and design tool, the time and difficulty required to create new simulations (or re-use existing simulations) often limits their application. This report describes the design of the software architecture for the Reconfigurable Flight Simulator (RFS), which provides a robust simulation framework that allows the simulator to fulfill multiple research and development goals. The core of the architecture provides the interface standards for simulation components, registers and initializes components, and handles the communication between simulation components. The simulation components are each a pre-compiled library 'plugin' module. This modularity allows independent development and sharing of individual simulation components. Additional interfaces can be provided through the use of Object Data/Method Extensions (OD/ME). RFS provides a programmable run-time environment for real-time access and manipulation, and has networking capabilities using the High Level Architecture (HLA).

  9. Design and Implementation of a Simulator for Photovoltaic Modules

    Directory of Open Access Journals (Sweden)

    Kuang-Hui Tang

    2012-01-01

    Full Text Available Proposed in this paper is the development of a photovoltaic module simulator, one capable of running an output characteristic simulation under normal operation according to various electrical parameters specified and exhibiting multiple advantages of being low cost, small sized, and easy to implement. In comparison with commercial simulation tools, Pspice and Solar Pro, the simulator developed demonstrates a comparable I-V as well as a P-V output characteristic curve. In addition, a series-parallel configuration of individual modules constitutes a photovoltaic module array, which turns into a photovoltaic power generation system with an integrated power conditioner.

  10. Simulation of design dependent failure exposure levels for CMOS ICs

    International Nuclear Information System (INIS)

    Kaul, N.; Bhuva, B.L.; Rangavajjhala, V.; van der Molen, H.; Kerns, S.E.

    1990-01-01

    The total dose exposure of CMOS ICs introduces bias-dependent parameter shifts in individual devices. The bias dependency of individual parameter shifts of devices cause different designs to behave differently under identical testing conditions. This paper studies the effect of design and bias on the radiation tolerance of ICs and presents an automated design tool that produces different designs for a logic function, and presents important parameters of each design to circuit designer for trade off analysis

  11. Comparison of HEC-RAS with FLDWAV and DAMBRK models for dam break analysis

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, R.D.; Judge, D.G.; Donnelly, C.R. [Acres International Ltd., Niagara Falls, ON (Canada)

    2004-09-01

    Dam break analysis is conducted as a routine dam safety assessment in determining the incremental hazard potential (IHP) that would occur in the event of a dam failure. Dam safety analysis also provides the information needed to make flood inundation maps and emergency preparedness plans (EPP) for dams that present a risk to human safety. For several years, the standard programs that have been used by the national weather service (NWS) for dam break flood simulation were the FLDWAV and DAMBRK models. However, another popular hydraulic model has been introduced. The HEC-RAS is an upgraded version of the former HEC-2 model used for the assessment of river floodplain inundation. A dam break analysis module has been added to HEC-2 and renamed the HEC-RAS which offers similar modeling capabilities to the DAMBRK and FLDWAV models for simulating flood hydrographs and flood wave propagation in river channels located downstream of a breached dam. The use of the alternative HEC-RAS could save time and resources. As such, it has the potential to replace the FLDWAV and DAMBRK. This paper compares the HEC-RAS dam break module with the FLDWAV and DAMBRK to determine if the new module accurately represents the dam break flood process. The comparison focuses on the theoretical background of the models, numerical solution techniques, ease of use of the module, modeling accuracy, practical aspects in performing dam break simulations, and capability for coupling the models with GIS for inundation mapping. The advantages and disadvantages of each model were summarized. 19 refs., 5 figs.

  12. Improving the Aircraft Design Process Using Web-based Modeling and Simulation

    Science.gov (United States)

    Reed, John A.; Follen, Gregory J.; Afjeh, Abdollah A.

    2003-01-01

    Designing and developing new aircraft systems is time-consuming and expensive. Computational simulation is a promising means for reducing design cycle times, but requires a flexible software environment capable of integrating advanced multidisciplinary and muitifidelity analysis methods, dynamically managing data across heterogeneous computing platforms, and distributing computationally complex tasks. Web-based simulation, with its emphasis on collaborative composition of simulation models, distributed heterogeneous execution, and dynamic multimedia documentation, has the potential to meet these requirements. This paper outlines the current aircraft design process, highlighting its problems and complexities, and presents our vision of an aircraft design process using Web-based modeling and simulation.

  13. Oncogenic N-Ras Stimulates SRF-Mediated Transactivation via H3 Acetylation at Lysine 9

    Directory of Open Access Journals (Sweden)

    Sun-Ju Yi

    2018-01-01

    Full Text Available Signal transduction pathways regulate the gene expression by altering chromatin dynamics in response to mitogens. Ras proteins are key regulators linking extracellular stimuli to a diverse range of biological responses associated with gene regulation. In mammals, the three ras genes encode four Ras protein isoforms: H-Ras, K-Ras4A, K-Ras4B, and N-Ras. Although emerging evidence suggests that Ras isoforms differentially regulate gene expressions and are functionally nonredundant, the mechanisms underlying Ras specificity and Ras signaling effects on gene expression remain unclear. Here, we show that oncogenic N-Ras acts as the most potent regulator of SRF-, NF-κB-, and AP-1-dependent transcription. N-Ras-RGL2 axis is a distinct signaling pathway for SRF target gene expression such as Egr1 and JunB, as RGL2 Ras binding domain (RBD significantly impaired oncogenic N-Ras-induced SRE activation. By monitoring the effect of Ras isoforms upon the change of global histone modifications in oncogenic Ras-overexpressed cells, we discovered that oncogenic N-Ras elevates H3K9ac/H3K23ac levels globally in the chromatin context. Importantly, chromatin immunoprecipitation (ChIP assays revealed that H3K9ac is significantly enriched at the promoter and coding regions of Egr1 and JunB. Collectively, our findings define an undocumented role of N-Ras in modulating of H3 acetylation and in gene regulation.

  14. System Design Description Salt Well Liquid Pumping Dynamic Simulation

    International Nuclear Information System (INIS)

    HARMSEN, R.W.

    1999-01-01

    The Salt Well Liquid (SWL) Pumping Dynamic Simulation used by the single-shell tank (SST) Interim Stabilization Project is described. A graphical dynamic simulation predicts SWL removal from 29 SSTs using an exponential function and unique time constant for each SST. Increasing quarterly efficiencies are applied to adjust the pumping rates during fiscal year 2000

  15. Building performance simulation for sustainable building design and operation

    NARCIS (Netherlands)

    Hensen, J.L.M.

    2011-01-01

    This paper aims to provide a general view of the background and current state of building performance simulation, which has the potential to deliver, directly or indirectly, substantial benefits to building stakeholders and to the environment. However the building simulation community faces many

  16. Regional scale flood modeling using NEXRAD rainfall, GIS, and HEC-HMS/RAS: a case study for the San Antonio River Basin Summer 2002 storm event.

    Science.gov (United States)

    Knebl, M R; Yang, Z-L; Hutchison, K; Maidment, D R

    2005-06-01

    This paper develops a framework for regional scale flood modeling that integrates NEXRAD Level III rainfall, GIS, and a hydrological model (HEC-HMS/RAS). The San Antonio River Basin (about 4000 square miles, 10,000 km2) in Central Texas, USA, is the domain of the study because it is a region subject to frequent occurrences of severe flash flooding. A major flood in the summer of 2002 is chosen as a case to examine the modeling framework. The model consists of a rainfall-runoff model (HEC-HMS) that converts precipitation excess to overland flow and channel runoff, as well as a hydraulic model (HEC-RAS) that models unsteady state flow through the river channel network based on the HEC-HMS-derived hydrographs. HEC-HMS is run on a 4 x 4 km grid in the domain, a resolution consistent with the resolution of NEXRAD rainfall taken from the local river authority. Watershed parameters are calibrated manually to produce a good simulation of discharge at 12 subbasins. With the calibrated discharge, HEC-RAS is capable of producing floodplain polygons that are comparable to the satellite imagery. The modeling framework presented in this study incorporates a portion of the recently developed GIS tool named Map to Map that has been created on a local scale and extends it to a regional scale. The results of this research will benefit future modeling efforts by providing a tool for hydrological forecasts of flooding on a regional scale. While designed for the San Antonio River Basin, this regional scale model may be used as a prototype for model applications in other areas of the country.

  17. Development of a HEC-RAS temperature model for the North Santiam River, northwestern Oregon

    Science.gov (United States)

    Stonewall, Adam J.; Buccola, Norman L.

    2015-01-01

    A one-dimensional, unsteady streamflow and temperature model (HEC-RAS) of the North Santiam and Santiam Rivers was developed by the U.S. Geological Survey to be used in conjunction with previously developed two-dimensional hydrodynamic water-quality models (CE-QUAL-W2) of Detroit and Big Cliff Lakes upstream of the study area. In conjunction with the output from the previously developed models, the HEC-RAS model can simulate streamflows and temperatures within acceptable limits (mean error [bias] near zero; typical streamflow errors less than 5 percent; typical water temperature errors less than 1.0 °C) for the length of the North Santiam River downstream of Big Cliff Dam under a series of potential future conditions in which dam structures and/or dam operations are modified to improve temperature conditions for threatened and endangered fish. Although a two-dimensional (longitudinal, vertical) CE-QUAL-W2 model for the North Santiam and Santiam Rivers downstream of Big Cliff Dam exists, that model proved unstable under highly variable flow conditions. The one-dimensional HEC-RAS model documented in this report can better simulate cross-sectional-averaged stream temperatures under a wide range of flow conditions.

  18. Multiphysics simulation by design for electrical machines, power electronics and drives

    CERN Document Server

    Rosu, Marius; Lin, Dingsheng; Ionel, Dan M; Popescu, Mircea; Blaabjerg, Frede; Rallabandi, Vandana; Staton, David

    2018-01-01

    This book combines the knowledge of experts from both academia and the software industry to present theories of multiphysics simulation by design for electrical machines, power electronics, and drives. The comprehensive design approach described within supports new applications required by technologies sustaining high drive efficiency. The highlighted framework considers the electric machine at the heart of the entire electric drive. The book also emphasizes the simulation by design concept--a concept that frames the entire highlighted design methodology, which is described and illustrated by various advanced simulation technologies. Multiphysics Simulation by Design for Electrical Machines, Power Electronics and Drives begins with the basics of electrical machine design and manufacturing tolerances. It also discusses fundamental aspects of the state of the art design process and includes examples from industrial practice. It explains FEM-based analysis techniques for electrical machine design--providing deta...

  19. Analysis of trade condition in Ras region

    Directory of Open Access Journals (Sweden)

    Andelić Slavica

    2017-01-01

    Full Text Available Modern academic literature in the field of trade in macro and mesoeconomic atmosphere, is trying to shed light on the data which defines exchange flows in intra and international environment. The study of this work is based on the database based through state registers, where with their sizing and analysis, we are coming to a deeper insight into the condition of market channels of Ras region and its relationship with the environment. The aim of this work is meticulous interpretation of trade patterns as a result of macro and meso trade policy, which could serve as an incentive for local and governmental structures in developing commercial potential of the southern part of our country.

  20. The study, design and simulation of a free piston Stirling engine linear alternatorThe study, design and simulation of a free piston Stirling engine linear alternator

    Directory of Open Access Journals (Sweden)

    Teodora Susana Oros

    2014-12-01

    Full Text Available This paper presents a study, design and simulation of a Free Piston Stirling Engine Linear Alternator. There are presented the main steps of the magnetic and electric calculations for a permanent magnet linear alternator of fixed coil and moving magnets type. Finally, a detailed thermal, mechanical and electrical model for a Stirling engine linear alternator have been made in SIMULINK simulation program. The linear alternator simulation model uses a controllable DC voltage which simulates the linear alternator combined with a rectifier, a variable load and a DC-DC converter, which compensates for the variable nature of Stirling engine operation, and ensures a constant voltage output regardless of the load.

  1. Feasibility studies and pre-design simulation of Warsaw's new wastewater treatment plant.

    Science.gov (United States)

    Oleszkiewicz, J A; Kalinowska, E; Dold, P; Barnard, J L; Bieniowski, M; Ferenc, Z; Jones, R; Rypina, A; Sudol, J

    2004-12-01

    The proposed transfer of wastewater from the western part of Warsaw, across the Wisla (Vistula) River for joint treatment at the existing eastern side "Czajka" wastewater treatment plant (WWTP) will result in combined winter flows of approx. 580,000 m3 d(-1). One-year of pilot-scale studies defined the COD characteristics and kinetics of nitrogen removal and VFA production from primary sludge. BioWin simulation was used to size and price the optional processes and pointed to the Westbank process as the most cost-effective. The process consists of a sequence of a RAS pre-denitrification zone followed by an anaerobic, anoxic and aerobic zone. Some 100-150 t d(-1) of 10% methanol would be needed to remove 2-4 mg l(-1) of NO3-N above the recommended effluent level TN = 10 mg l(-1). Applying the principle of annual average 80% TN removal, and allowing for use of daily composite samples (rather than grab) could annually save the municipality over 1.5 million Euro on external carbon source.

  2. Design, Construct and Test the Hi-Therm Simulator

    National Research Council Canada - National Science Library

    Zavitsanos, Peter

    1998-01-01

    Under the previous SBIR programs, GSI investigated the application of highly exothermic intermetallic reactions with the most energetic of these reactions constituting the basis for the Hi-Therm Simulator...

  3. The design of a network emulation and simulation laboratory

    CSIR Research Space (South Africa)

    Von Solms, S

    2015-07-01

    Full Text Available The development of the Network Emulation and Simulation Laboratory is motivated by the drive to contribute to the enhancement of the security and resilience of South Africa's critical information infrastructure. The goal of the Network Emulation...

  4. Use of Torness simulator as a design and commissioning tool

    International Nuclear Information System (INIS)

    Hamilton, J.; Hacking, D.

    1989-01-01

    Real-time replica control room simulators are now in general use for the training of nuclear power plant operators, and the almost universal trend towards accurate physics-based plant models and detailed operator interface has opened up interesting and valuable engineering applications. This paper discusses the use of the Torness AGR Simulator in its dual role of commissioning support tool and operator training facility. (author)

  5. Electrical design and control. Simulation platform to model, optimice and design windturbines; Elektrisk design og styring - simuleringsplatform til modellering, optimering og design af vindmoeller

    Energy Technology Data Exchange (ETDEWEB)

    Iov, F.; Timbus, A.V.; Hansen, A.D.; Soerensen, P.; Blaabjerg, F.

    2004-03-01

    This report is a general overview of the results obtained in the project 'Electrical Design and Control. Simulation Platform to Model, Optimize and Design Wind Turbines'. The motivation for this research project is the ever-increasing wind energy penetration into the power network. Therefore, the project has the main goal to create a model database in different simulation tools for a system optimization of the wind turbine systems. Using this model database a simultaneous optimization of the aerodynamic, mechanical, electrical and control systems over the whole range of wind speeds and grid characteristics can be achieved. The report is structured in six chapters. First, the background of this project and the main goals as well as the structure of the simulation platform is given. The main topologies for wind turbines, which have been taken into account during the project, are briefly presented. Then, the considered simulation tools narrely: HAWC, DIgSILENT, Saber and Matlab/Simulink have been used in this simulation platform are described. The focus here is on the modelling and simulation time scale aspects. The abilities of these tools are complementary and they can together cover all the modelling aspects of the wind turbines e.g. mechanical loads, power quality, switching, control and grid faults. However, other simulation packages e.g PSCAD/EMTDC can easily be added in the simulation platform. New models and new Control algorithms for wind turbine systems have been developed and tested in these tools. All these models are collected in dedicated libraries in Matlab/Simulink as well as in Saber. Some simulation results from the considered tools are presented for MW wind turbines. These simulation results focuses on fixed-speed and variable speed/pitch wind turbines. A good agreement with the real behaviour of these systems is obtained for each simulation tool. These models can easily be extended to model different kinds of wind turbines or large wind

  6. RasGRP3 regulates the migration of glioma cells via interaction with Arp3

    Science.gov (United States)

    Lee, Hae Kyung; Finniss, Susan; Cazacu, Simona; Xiang, Cunli; Poisson, Laila M.; Blumberg, Peter M.; Brodie, Chaya

    2015-01-01

    Glioblastoma (GBM), the most aggressive primary brain tumors, are highly infiltrative. Although GBM express high Ras activity and Ras proteins have been implicated in gliomagenesis, Ras-activating mutations are not frequent in these tumors. RasGRP3, an important signaling protein responsive to diacylglycerol (DAG), increases Ras activation. Here, we examined the expression and functions of RasGRP3 in GBM and glioma cells. RasGRP3 expression was upregulated in GBM specimens and glioma stem cells compared with normal brains and neural stem cells, respectively. RasGRP3 activated Ras and Rap1 in glioma cells and increased cell migration and invasion partially via Ras activation. Using pull-down assay and mass spectroscopy we identified the actin-related protein, Arp3, as a novel interacting protein of RasGRP3. The interaction of RasGRP3 and Arp3 was validated by immunofluorescence staining and co-immunoprecipitation, and PMA, which activates RasGRP3 and induces its translocation to the peri-nuclear region, increased the association of Arp3 and RasGRP3. Arp3 was upregulated in GBM, regulated cell spreading and migration and its silencing partially decreased these effects of RasGRP3 in glioma cells. In summary, RasGRP3 acts as an important integrating signaling protein of the DAG and Ras signaling pathways and actin polymerization and represents an important therapeutic target in GBM. PMID:25682201

  7. Spectrum of K ras mutations in Pakistani colorectal cancer patients

    Energy Technology Data Exchange (ETDEWEB)

    Murtaza, B.N.; Bibi, A. [School of Biological Sciences, University of the Punjab, Quaid-i-Azam Campus, Lahore (Pakistan); Rashid, M.U.; Khan, Y.I. [Shaukat Khanum Memorial Cancer Hospital and Research Centre, Johar Town, Lahore (Pakistan); Chaudri, M.S. [Services Institute of Medical Sciences, Lahore (Pakistan); Shakoori, A.R. [School of Biological Sciences, University of the Punjab, Quaid-i-Azam Campus, Lahore (Pakistan)

    2013-11-29

    The incidence of colorectal cancer (CRC) is increasing daily worldwide. Although different aspects of CRC have been studied in other parts of the world, relatively little or almost no information is available in Pakistan about different aspects of this disease at the molecular level. The present study was aimed at determining the frequency and prevalence of K ras gene mutations in Pakistani CRC patients. Tissue and blood samples of 150 CRC patients (64% male and 36% female) were used for PCR amplification of K ras and detection of mutations by denaturing gradient gel electrophoresis, restriction fragment length polymorphism analysis, and nucleotide sequencing. The K ras mutation frequency was found to be 13%, and the most prevalent mutations were found at codons 12 and 13. A novel mutation was also found at codon 31. The dominant mutation observed was a G to A transition. Female patients were more susceptible to K ras mutations, and these mutations were predominant in patients with a nonmetastatic stage of CRC. No significant differences in the prevalence of K ras mutations were observed for patient age, gender, or tumor type. It can be inferred from this study that Pakistani CRC patients have a lower frequency of K ras mutations compared to those observed in other parts of the world, and that K ras mutations seemed to be significantly associated with female patients.

  8. Spectrum of K ras mutations in Pakistani colorectal cancer patients

    International Nuclear Information System (INIS)

    Murtaza, B.N.; Bibi, A.; Rashid, M.U.; Khan, Y.I.; Chaudri, M.S.; Shakoori, A.R.

    2013-01-01

    The incidence of colorectal cancer (CRC) is increasing daily worldwide. Although different aspects of CRC have been studied in other parts of the world, relatively little or almost no information is available in Pakistan about different aspects of this disease at the molecular level. The present study was aimed at determining the frequency and prevalence of K ras gene mutations in Pakistani CRC patients. Tissue and blood samples of 150 CRC patients (64% male and 36% female) were used for PCR amplification of K ras and detection of mutations by denaturing gradient gel electrophoresis, restriction fragment length polymorphism analysis, and nucleotide sequencing. The K ras mutation frequency was found to be 13%, and the most prevalent mutations were found at codons 12 and 13. A novel mutation was also found at codon 31. The dominant mutation observed was a G to A transition. Female patients were more susceptible to K ras mutations, and these mutations were predominant in patients with a nonmetastatic stage of CRC. No significant differences in the prevalence of K ras mutations were observed for patient age, gender, or tumor type. It can be inferred from this study that Pakistani CRC patients have a lower frequency of K ras mutations compared to those observed in other parts of the world, and that K ras mutations seemed to be significantly associated with female patients

  9. Clinical simulation as a boundary object in design of health IT-systems

    DEFF Research Database (Denmark)

    Rasmussen, Stine Loft; Jensen, Sanne; Lyng, Karen Marie

    2013-01-01

    simulation provides the opportunity to evaluate the design and the usage of clinical IT-systems without endangering the patients and interrupting clinical work. In this paper we present how clinical simulation additionally holds the potential to function as a boundary object in the design process. The case...... points out that clinical simulation provides an opportunity for discussions and mutual learning among the various stakeholders involved in design of standardized electronic clinical documentation templates. The paper presents and discusses the use of clinical simulation in the translation, transfer...... and transformation of knowledge between various stakeholders in a large healthcare organization...

  10. Simulation based design strategy for EMC compliance of components in hybrid vehicles

    Energy Technology Data Exchange (ETDEWEB)

    Maass, Uwe; Ndip, Ivan; Hoene, Eckard; Guttowski, Stephan [Fraunhofer-Institut fuer Zuverlaessigkeit und Mikrointegration (IZM), Berlin (Germany); Tschoban, Christian; Lang, Klaus-Dieter [Technische Univ. Berlin (Germany)

    2012-11-01

    The design of components for the power train of hybrid vehicles needs to take into account EMC compliance standards related to hazardous electromagnetic fields. Using a simulation based design strategy allows for virtual EMC tests in parallel to the mechanical / electrical power design and thus reduces (re-)design time and costs. Taking as an example a high-voltage battery for a hybrid vehicle the emitted magnetic fields outside the battery are examined. The simulation stategy is based on 3D EM simulations using a full-wave and an eddy current solver. The simulation models are based on the actual CAD data from the mechanical construction resulting in and a high geometrical aspect ratio. The impact of simulation specific aspects such as boundary conditions and excitation is given. It was found that using field simulations it is possible to identify noise sources and coupling paths as well as aid the construction of the battery. (orig.)

  11. Achieving informed decision-making for net zero energy buildings design using building performance simulation tools

    NARCIS (Netherlands)

    Attia, S.G.; Gratia, E.; De Herde, A.; Hensen, J.L.M.

    2013-01-01

    Building performance simulation (BPS) is the basis for informed decision-making of Net Zero Energy Buildings (NZEBs) design. This paper aims to investigate the use of building performance simulation tools as a method of informing the design decision of NZEBs. The aim of this study is to evaluate the

  12. Customized sequential designs for random simulation experiments: Kriging metamodeling and bootstrapping

    NARCIS (Netherlands)

    Beers, van W.C.M.; Kleijnen, J.P.C.

    2005-01-01

    This paper proposes a novel method to select an experimental design for interpolation in random simulation, especially discrete event simulation. (Though the paper focuses on Kriging, this design approach may also apply to other types of metamodels such as linear regression models.) Assuming that

  13. The Process of Participatory Ergonomics Simulation in Hospital Work System Design

    DEFF Research Database (Denmark)

    Andersen, Simone Nyholm

    2016-01-01

    Participatory ergonomics simulation (PES) is a method to involve workers in simulation and design of their own future work system. Understanding of the process of PES is crucial in order to plan and facilitate the process towards creating an ergonomics work system design supporting both human well...

  14. A framework for using simulation methodology in ergonomics interventions in design projects

    DEFF Research Database (Denmark)

    Broberg, Ole; Duarte, Francisco; Andersen, Simone Nyholm

    2014-01-01

    The aim of this paper is to outline a framework of simulation methodology in design processes from an ergonomics perspective......The aim of this paper is to outline a framework of simulation methodology in design processes from an ergonomics perspective...

  15. Ideas in Practice (3): A Simulated Laboratory Experience in Digital Design.

    Science.gov (United States)

    Cleaver, Thomas G.

    1988-01-01

    Gives an example of the use of a simplified logic simulator in a logic design course. Discusses some problems in logic design classes, commercially available software, and software problems. Describes computer-aided engineering (CAE) software. Lists 14 experiments in the simulated laboratory and presents students' evaluation of the course. (YP)

  16. Conceptual Design of Simulation Models in an Early Development Phase of Lunar Spacecraft Simulator Using SMP2 Standard

    Science.gov (United States)

    Lee, Hoon Hee; Koo, Cheol Hea; Moon, Sung Tae; Han, Sang Hyuck; Ju, Gwang Hyeok

    2013-08-01

    The conceptual study for Korean lunar orbiter/lander prototype has been performed in Korea Aerospace Research Institute (KARI). Across diverse space programs around European countries, a variety of simulation application has been developed using SMP2 (Simulation Modelling Platform) standard related to portability and reuse of simulation models by various model users. KARI has not only first-hand experience of a development of SMP compatible simulation environment but also an ongoing study to apply the SMP2 development process of simulation model to a simulator development project for lunar missions. KARI has tried to extend the coverage of the development domain based on SMP2 standard across the whole simulation model life-cycle from software design to its validation through a lunar exploration project. Figure. 1 shows a snapshot from a visualization tool for the simulation of lunar lander motion. In reality, a demonstrator prototype on the right-hand side of image was made and tested in 2012. In an early phase of simulator development prior to a kick-off start in the near future, targeted hardware to be modelled has been investigated and indentified at the end of 2012. The architectural breakdown of the lunar simulator at system level was performed and the architecture with a hierarchical tree of models from the system to parts at lower level has been established. Finally, SMP Documents such as Catalogue, Assembly, Schedule and so on were converted using a XML(eXtensible Mark-up Language) converter. To obtain benefits of the suggested approaches and design mechanisms in SMP2 standard as far as possible, the object-oriented and component-based design concepts were strictly chosen throughout a whole model development process.

  17. Integrated Design Validation: Combining Simulation and Formal Verification for Digital Integrated Circuits

    Directory of Open Access Journals (Sweden)

    Lun Li

    2006-04-01

    Full Text Available The correct design of complex hardware continues to challenge engineers. Bugs in a design that are not uncovered in early design stages can be extremely expensive. Simulation is a predominantly used tool to validate a design in industry. Formal verification overcomes the weakness of exhaustive simulation by applying mathematical methodologies to validate a design. The work described here focuses upon a technique that integrates the best characteristics of both simulation and formal verification methods to provide an effective design validation tool, referred as Integrated Design Validation (IDV. The novelty in this approach consists of three components, circuit complexity analysis, partitioning based on design hierarchy, and coverage analysis. The circuit complexity analyzer and partitioning decompose a large design into sub-components and feed sub-components to different verification and/or simulation tools based upon known existing strengths of modern verification and simulation tools. The coverage analysis unit computes the coverage of design validation and improves the coverage by further partitioning. Various simulation and verification tools comprising IDV are evaluated and an example is used to illustrate the overall validation process. The overall process successfully validates the example to a high coverage rate within a short time. The experimental result shows that our approach is a very promising design validation method.

  18. An intelligent simulation environment for control system design

    International Nuclear Information System (INIS)

    Robinson, J.T.

    1989-01-01

    The Oak Ridge National Laboratory is currently assisting in the development of advanced control systems for the next generation of nuclear power plants. This paper presents a prototype interactive and intelligent simulation environment being developed to support this effort. The environment combines tools from the field of Artificial Intelligence; in particular object-oriented programming, a LISP programming environment, and a direct manipulation user interface; with traditional numerical methods for simulating combined continuous/discrete processes. The resulting environment is highly interactive and easy to use. Models may be created and modified quickly through a window oriented direct manipulation interface. Models may be modified at any time, even as the simulation is running, and the results observed immediately via real-time graphics. 8 refs., 3 figs

  19. Discrete-event simulation for the design and evaluation of physical protection systems

    International Nuclear Information System (INIS)

    Jordan, S.E.; Snell, M.K.; Madsen, M.M.; Smith, J.S.; Peters, B.A.

    1998-01-01

    This paper explores the use of discrete-event simulation for the design and control of physical protection systems for fixed-site facilities housing items of significant value. It begins by discussing several modeling and simulation activities currently performed in designing and analyzing these protection systems and then discusses capabilities that design/analysis tools should have. The remainder of the article then discusses in detail how some of these new capabilities have been implemented in software to achieve a prototype design and analysis tool. The simulation software technology provides a communications mechanism between a running simulation and one or more external programs. In the prototype security analysis tool, these capabilities are used to facilitate human-in-the-loop interaction and to support a real-time connection to a virtual reality (VR) model of the facility being analyzed. This simulation tool can be used for both training (in real-time mode) and facility analysis and design (in fast mode)

  20. Refrigeration Cycle Design for Refrigerant Mixtures by Molecular Simulation

    Czech Academy of Sciences Publication Activity Database

    Smith, W.R.; Francová, Magda; Kowalski, M.; Nezbeda, Ivo

    2010-01-01

    Roč. 75, č. 4 (2010), s. 383-391 ISSN 0010-0765 R&D Projects: GA AV ČR IAA400720710 Grant - others:NSERC(CA) OGP1041 Institutional research plan: CEZ:AV0Z40720504 Keywords : refrigerants * molecular simulation s * vapor–liquid equilibrium Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 0.853, year: 2010

  1. Knowledge-Driven Design of Virtual Patient Simulations

    Science.gov (United States)

    Vergara, Victor; Caudell, Thomas; Goldsmith, Timothy; Panaiotis; Alverson, Dale

    2009-01-01

    Virtual worlds provide unique opportunities for instructors to promote, study, and evaluate student learning and comprehension. In this article, Victor Vergara, Thomas Caudell, Timothy Goldsmith, Panaiotis, and Dale Alverson explore the advantages of using virtual reality environments to create simulations for medical students. Virtual simulations…

  2. Detectors for the superconducting super collider, design concepts, and simulation

    Energy Technology Data Exchange (ETDEWEB)

    Gabriel, T.A.

    1989-06-01

    The physics of compensation calorimetry is reviewed in the light of the needs of the Superconducting Super Collider (SSC) detectors. The four major detector types: liquid argon, scintillator, room temperature liquids, and silicon, are analyzed with respect to some of their strengths and weaknesses. Finally, general comments are presented which reflect the reliability of simulation code systems.

  3. Design of wave breaking experiments and A-Posteriori Simulations

    NARCIS (Netherlands)

    Kurnia, R.; Kurnia, Ruddy; van Groesen, Embrecht W.C.

    2014-01-01

    This report presents results of 30 wave breaking experiments conducted in the long wave tank of TU Delft, Department of Maritime and Transport Technology (6,7 and 10-12 March 2014), together with simulations performed before the experiment to determine the required wave maker motion and a-posteriori

  4. Design of wave breaking experiments and A-Posteriori Simulations

    NARCIS (Netherlands)

    Kurnia, Ruddy; van Groesen, Embrecht W.C.

    This report presents results of 30 wave breaking experiments conducted in the long wave tank of TU Delft, Department of Maritime and Transport Technology (6,7 and 10-12 March 2014), together with simulations performed before the experiment to determine the required wave maker motion and a-posteriori

  5. Contribution to study and design of PWR plant simulation code

    International Nuclear Information System (INIS)

    Delourme, Didier.

    1980-11-01

    This paper presents an improvement of PICOLO, a package for PWR plants simulation. Its describes principally the integration to the code of a primary loop and pressurizer model and the corresponding control loops. Fast transients are tested on the packages and results are compared with real transients obtained on plants [fr

  6. Design Heuristics for Authentic Simulation-Based Learning Games

    Science.gov (United States)

    Ney, Muriel; Gonçalves, Celso; Balacheff, Nicolas

    2014-01-01

    Simulation games are games for learning based on a reference in the real world. We propose a model for authenticity in this context as a result of a compromise among learning, playing and realism. In the health game used to apply this model, students interact with characters in the game through phone messages, mail messages, SMS and video.…

  7. Detectors for the superconducting super collider, design concepts, and simulation

    International Nuclear Information System (INIS)

    Gabriel, T.A.

    1989-06-01

    The physics of compensation calorimetry is reviewed in the light of the needs of the Superconducting Super Collider (SSC) detectors. The four major detector types: liquid argon, scintillator, room temperature liquids, and silicon, are analyzed with respect to some of their strengths and weaknesses. Finally, general comments are presented which reflect the reliability of simulation code systems

  8. Detectors for the Superconducting Super Collider, design concepts, and simulation

    International Nuclear Information System (INIS)

    Gabriel, T.A.

    1989-01-01

    The physics of compensation calorimetry is reviewed in the light of the need of the Superconducting Super Collider (SSC) detectors. The four major detector types: liquid argon, scintillator, room temperature liquids, and silicon, are analyzed with respect to some of their strengths and weaknesses. Finally, general comments are presented which reflect the reliability of simulation code systems. 29 refs., 20 figs., 6 tabs

  9. Design and Analysis of Windmill Simulation and Pole by Solidwork Program

    Science.gov (United States)

    Mulyana, Tatang; Sebayang, Darwin; R, Akmal Muamar. D.; A, Jauharah H. D.; Yahya Shomit, M.

    2018-03-01

    The Indonesian state of archipelago has great wind energy potential. For micro-scale power generation, the energy obtained from the windmill can be connected directly to the electrical load and can be used without problems. However, for macro-scale power generation, problems will arise such as the design of vane shapes, there should be a simulation and an accurate experiment to produce blades with a special shape that can capture wind energy. In addition, daily and yearly wind and wind rate calculations are also required to ensure the best latitude and longitude positions for building windmills. This paper presents a solution to solve the problem of how to produce a windmill which in the builder is very practical and very mobile can be moved its location. Before a windmill prototype is built it should have obtained the best windmill design result. Therefore, the simulation of the designed windmill is of crucial importance. Solid simulation express is a tool that serves to generate simulation of a design. Some factors that can affect a design result include the power part and the rest part of the part, material selection, the load is given, the security of the design power made, and changes in shape due to treat the load given to the design made. In this paper, static and thermal simulations of windmills have been designed. Based on the simulation result on the designed windmill, it shows that the design has been made very satisfactory so that it can be done prototyping fabrication process.

  10. SMI Compatible Simulation Scheduler Design for Reuse of Model Complying with SMP Standard

    Directory of Open Access Journals (Sweden)

    Cheol-Hea Koo

    2010-12-01

    Full Text Available Software reusability is one of key factors which impacts cost and schedule on a software development project. It is very crucial also in satellite simulator development since there are many commercial simulator models related to satellite and dynamics. If these models can be used in another simulator platform, great deal of confidence and cost/schedule reduction would be achieved. Simulation model portability (SMP is maintained by European Space Agency and many models compatible with SMP/simulation model interface (SMI are available. Korea Aerospace Research Institute (KARI is developing hardware abstraction layer (HAL supported satellite simulator to verify on-board software of satellite. From above reasons, KARI wants to port these SMI compatible models to the HAL supported satellite simulator. To port these SMI compatible models to the HAL supported satellite simulator, simulation scheduler is preliminary designed according to the SMI standard.

  11. Diet, Lifestyle and risk of K-ras mutation-positive and -negative colorectal adenomas

    NARCIS (Netherlands)

    Wark, P.A.; Kuil, van der W.; Ploemacher, J.; Muijen, van G.N.P.; Mulder, Ch.J.J.; Weijenberg, M.P.; Kok, F.J.; Kampman, E.

    2006-01-01

    K-ras mutation-positive (K-ras+) and -negative (K-ras-) colorectal adenomas may differ clinically and pathologically. As environmental compounds may cause mutations in the growth-related K-ras oncogene or affect clonal selection depending on mutational status, we evaluated whether the aetiology of

  12. Aiding Design of Wave Energy Converters via Computational Simulations

    Science.gov (United States)

    Jebeli Aqdam, Hejar; Ahmadi, Babak; Raessi, Mehdi; Tootkaboni, Mazdak

    2015-11-01

    With the increasing interest in renewable energy sources, wave energy converters will continue to gain attention as a viable alternative to current electricity production methods. It is therefore crucial to develop computational tools for the design and analysis of wave energy converters. A successful design requires balance between the design performance and cost. Here an analytical solution is used for the approximate analysis of interactions between a flap-type wave energy converter (WEC) and waves. The method is verified using other flow solvers and experimental test cases. Then the model is used in conjunction with a powerful heuristic optimization engine, Charged System Search (CSS) to explore the WEC design space. CSS is inspired by charged particles behavior. It searches the design space by considering candidate answers as charged particles and moving them based on the Coulomb's laws of electrostatics and Newton's laws of motion to find the global optimum. Finally the impacts of changes in different design parameters on the power takeout of the superior WEC designs are investigated. National Science Foundation, CBET-1236462.

  13. The Process of Participatory Ergonomics Simulation in Hospital Work System Design

    OpenAIRE

    Andersen, Simone Nyholm

    2016-01-01

    Participatory ergonomics simulation (PES) is a method to involve workers in simulation and design of their own future work system. Understanding of the process of PES is crucial in order to plan and facilitate the process towards creating an ergonomics work system design supporting both human well-being and overall system performance. With outset in two cases of PES in hospital work system design, this study investigates the elements of the PES process and their interrelations. The aim is to ...

  14. Building simulations supporting decision making in early design – A review

    DEFF Research Database (Denmark)

    Østergård, Torben; Jensen, Rasmus Lund; Maagaard, Steffen

    2016-01-01

    The building design community is challenged by continuously increasing energy demands, which are often combined with ambitious goals for indoor environment, for environmental impact, and for building costs. To aid decision-making, building simulation is widely used in the late design stages...... framework that facilitates proactive, intelligent, and experience based building simulation which aid decision making in early design. To find software candidates accommodating this framework, we compare existing software with regard to intended usage, interoperability, complexity, objectives, and ability...

  15. High Altitude Venus Operations Concept Trajectory Design, Modeling and Simulation

    Science.gov (United States)

    Lugo, Rafael A.; Ozoroski, Thomas A.; Van Norman, John W.; Arney, Dale C.; Dec, John A.; Jones, Christopher A.; Zumwalt, Carlie H.

    2015-01-01

    A trajectory design and analysis that describes aerocapture, entry, descent, and inflation of manned and unmanned High Altitude Venus Operation Concept (HAVOC) lighter-than-air missions is presented. Mission motivation, concept of operations, and notional entry vehicle designs are presented. The initial trajectory design space is analyzed and discussed before investigating specific trajectories that are deemed representative of a feasible Venus mission. Under the project assumptions, while the high-mass crewed mission will require further research into aerodynamic decelerator technology, it was determined that the unmanned robotic mission is feasible using current technology.

  16. Manpower simulation for the power plant design engineering

    International Nuclear Information System (INIS)

    Moon, B.S.; Juhn, P.E.

    1982-01-01

    Some observation from the examination of actual manhour curves for the power design engineering obtained from Sargent and Lundy Engineers and of a few of the model curves proposed by Bechtel, are analyzed in this paper. A model curve representing typical design engineering manhour has been determined as probability density function for the Gamma Distribution. By means of this model curve, we strategically forecast the future engineering manpower requirements to meet the Covernment's long range nuclear power plan. As a sensitivity analysis, the directions for the localization of nuclear power plant design engineering, are studied in terms of the performance factor for the experienced versus inexperienced engineers. (Author)

  17. High-Alpha Research Vehicle (HARV) longitudinal controller: Design, analyses, and simulation resultss

    Science.gov (United States)

    Ostroff, Aaron J.; Hoffler, Keith D.; Proffitt, Melissa S.; Brown, Philip W.; Phillips, Michael R.; Rivers, Robert A.; Messina, Michael D.; Carzoo, Susan W.; Bacon, Barton J.; Foster, John F.

    1994-01-01

    This paper describes the design, analysis, and nonlinear simulation results (batch and piloted) for a longitudinal controller which is scheduled to be flight-tested on the High-Alpha Research Vehicle (HARV). The HARV is an F-18 airplane modified for and equipped with multi-axis thrust vectoring. The paper includes a description of the facilities, a detailed review of the feedback controller design, linear analysis results of the feedback controller, a description of the feed-forward controller design, nonlinear batch simulation results, and piloted simulation results. Batch simulation results include maximum pitch stick agility responses, angle of attack alpha captures, and alpha regulation for full lateral stick rolls at several alpha's. Piloted simulation results include task descriptions for several types of maneuvers, task guidelines, the corresponding Cooper-Harper ratings from three test pilots, and some pilot comments. The ratings show that desirable criteria are achieved for almost all of the piloted simulation tasks.

  18. Basic architecture and design of storage simulation construction set

    International Nuclear Information System (INIS)

    Sehgal, A.; Volz, R.

    1999-02-01

    Regular practice these days has been to build a simulation prototype of an actual entity needing to be built prior to building an actual physical model. Computer simulation and modeling techniques aid greatly in this practice. In a critical system such as a fissile material storage system, various issues such as safety, security, and automation of handling processes can be assessed through virtual environments, thereby creating a safe atmosphere for research versus hands-on experimentation and possible worker exposures. By utilizing the approaches presented in this study, the concepts can be applied for rapid virtual prototyping of other systems, as this type of system is not limited to the storage of nuclear materials

  19. Design and simulation of airport congestion control algorithms

    OpenAIRE

    Simaiakis, Ioannis; Balakrishnan, Hamsa

    2014-01-01

    This paper proposes a stochastic model of runway departures and a dynamic programming algorithm for their control at congested airports. Using a multi-variable state description that includes the capacity forecast, the runway system is modeled as a semi-Markov process. The paper then introduces a queuing system for modeling the controlled departure process that enables the efficient calculation of optimal pushback policies using decomposition techniques. The developed algorithm is simulated a...

  20. Simulation and visualization tool design for robot software

    NARCIS (Netherlands)

    Lu, Zhou; Ran, Tjalling; Broenink, Johannes F.; Chalmers, K.; Pedersen, J.B.

    2016-01-01

    Modern embedded systems are designed for multiple and increasingly demanding tasks. Complex concurrent software is required by multi-task automated service robotics for implementing their challenging (control) algorithms. TERRA is a communicating Sequential Processes (CSP) algebra-based Eclipse

  1. Practical design of magnetostatic structure using numerical simulation

    CERN Document Server

    Wang, Qiuliang

    2013-01-01

    Covers the practical numerical method for the analysis and design of magnets Extensively covers the magnet design and computation aspects from theories to practical applications, emphasizing design methods of practical structures such as superconducting, electromagnetic and permanent magnet for use in various scientific instruments, industrial processing, biomedicine and special electrical equipments. The computations cover a wide range of numerical techniques and analytical derivation to efficiently provide solutions to complicated problems that are often encountered in practice, where simple analytical calculations are no longer adequate. Chapters include: Introduction of Magnet Technology, Magnetostatic Equation for the Magnet Structure, Finite Element Analysis for Magnetostatic Field, Integral Method for Magnetostatic Field, Numerical Method of Solenoid Coils Design, Series Analysis of Axially Symmetric Magnetic Field, Magnets with High Magnetic Field and High Homogeneity, Permanent Magnet and its App...

  2. The design, development and operation of a compact nuclear power plant simulator

    International Nuclear Information System (INIS)

    Lynch, M.F.

    1987-01-01

    This paper discusses the philosophy and technological considerations necessary for constructing and utilizing a plant specific compact nuclear power plant simulator, how it compares to full scope replica simulators, engineering simulators, part task simulators and basic principles training simulators. Included in this discussion are the design process, scope of simulation, the manufacturing process, test programs and experiences with operator training. Items addressed include the applicability and use of a compact simulator, how well it reproduces the actual reference plant, how well the transferral of knowledge is accomplished and what financial considerations need to be evaluated. This paper tries to provide the details on just how this type of machine was designed and developed by Westinghouse for the Swiss Utility, Nordostschweizerische Kraftwerke (NOK) AG

  3. Virtual tool for simulation and wind turbine design

    International Nuclear Information System (INIS)

    Monteiro Farias, Gustavo; Barros Galhardo, Marcos André; Tavares Pinho, João

    2015-01-01

    This paper presents an educational tool to simulate wind turbines in a virtual environment. This tool can be used for research applications as well as to evaluate the operation conditions of a wind turbine by reproducing its behaviour. The first step is to apply the Blade Element Theory in order to obtain the induction factors when the tip- speed ratio and the airfoil characteristics are configured. With these values as starting point, the geometric shape of the wind blade is created and visualized. In order to evaluate the performance of the turbine, an integration method is applied, and then the power coefficient curve is plotted versus the tip-speed ratio. The power coefficient curve reaches the maximum value at the rated operation, which is essential to the transient behaviour of the wind turbine. The transient model described in this work shows the influence of all efforts acting on the rotor, which disturb the rotation. The inertial mass of the components and the air density are set up during the simulation.Using the virtual instrumentation applied to the transient model together with a 3D computer animation, the variables of the program can be controlled and visualized in graphics, and the animation of the wind turbine shows when it accelerates or decelerates the shaft rotation due to the variation of the wind speed. The tool provides the power supplied by the wind rotor to the electric generator, which can be evaluated at the end of the simulation. (full text)

  4. The C-terminus of H-Ras as a target for the covalent binding of reactive compounds modulating Ras-dependent pathways.

    Directory of Open Access Journals (Sweden)

    Clara L Oeste

    2011-01-01

    Full Text Available Ras proteins are crucial players in differentiation and oncogenesis and constitute important drug targets. The localization and activity of Ras proteins are highly dependent on posttranslational modifications at their C-termini. In addition to an isoprenylated cysteine, H-Ras, but not other Ras proteins, possesses two cysteine residues (C181 and C184 in the C-terminal hypervariable domain that act as palmitoylation sites in cells. Cyclopentenone prostaglandins (cyPG are reactive lipidic mediators that covalently bind to H-Ras and activate H-Ras dependent pathways. Dienone cyPG, such as 15-deoxy-Δ(12,14-PGJ(2 (15d-PGJ(2 and Δ(12-PGJ(2 selectively bind to the H-Ras hypervariable domain. Here we show that these cyPG bind simultaneously C181 and C184 of H-Ras, thus potentially altering the conformational tendencies of the hypervariable domain. Based on these results, we have explored the capacity of several bifunctional cysteine reactive small molecules to bind to the hypervariable domain of H-Ras proteins. Interestingly, phenylarsine oxide (PAO, a widely used tyrosine phosphatase inhibitor, and dibromobimane, a cross-linking agent used for cysteine mapping, effectively bind H-Ras hypervariable domain. The interaction of PAO with H-Ras takes place in vitro and in cells and blocks modification of H-Ras by 15d-PGJ(2. Moreover, PAO treatment selectively alters H-Ras membrane partition and the pattern of H-Ras activation in cells, from the plasma membrane to endomembranes. These results identify H-Ras as a novel target for PAO. More importantly, these observations reveal that small molecules or reactive intermediates interacting with spatially vicinal cysteines induce intramolecular cross-linking of H-Ras C-terminus potentially contributing to the modulation of Ras-dependent pathways.

  5. Genetic and Molecular Analysis of Suppressors of Ras Mutations

    National Research Council Canada - National Science Library

    Sieburth, Derek

    1998-01-01

    .... elegans vulval development. We describe the identification and characterization of a novel gene, sur-8, that functions to regulate a receptor tyrosine kinase-Ras-MAP kinase-mediated signal transduction pathway during C...

  6. Genetic and Molecular Analysis of Suppressors of Ras Mutations

    National Research Council Canada - National Science Library

    Sieburth, Derek

    1999-01-01

    .... elegans vulvaZ development. We describe the identification and characterization of a novel gene, sur-8, that functions to regulate a receptor tyrosine kinase-Ras-MAp kinase- mediated signal transduction pathway during C...

  7. Advanced Information Technology in Simulation Based Life Cycle Design

    Science.gov (United States)

    Renaud, John E.

    2003-01-01

    In this research a Collaborative Optimization (CO) approach for multidisciplinary systems design is used to develop a decision based design framework for non-deterministic optimization. To date CO strategies have been developed for use in application to deterministic systems design problems. In this research the decision based design (DBD) framework proposed by Hazelrigg is modified for use in a collaborative optimization framework. The Hazelrigg framework as originally proposed provides a single level optimization strategy that combines engineering decisions with business decisions in a single level optimization. By transforming this framework for use in collaborative optimization one can decompose the business and engineering decision making processes. In the new multilevel framework of Decision Based Collaborative Optimization (DBCO) the business decisions are made at the system level. These business decisions result in a set of engineering performance targets that disciplinary engineering design teams seek to satisfy as part of subspace optimizations. The Decision Based Collaborative Optimization framework more accurately models the existing relationship between business and engineering in multidisciplinary systems design.

  8. Research and Application of Virtual Simulation Technology in the Aerospace Bearing Design and Manufacture

    Directory of Open Access Journals (Sweden)

    Jiangshan Liu

    2018-01-01

    Full Text Available Bearings are widely used in aerospace and other fields, its performance directly affects the production efficiency and safety. Nowadays, virtual simulation technology has become an indispensable part of intelligent manufacturing field. As a virtual simulation technology, FEA has been widely used in bearing design. China needs to import many aerospace bearings every year in aerospace area, Chinese national defense and other high precision technology is limited because the blockade of advanced bearing technology. We can use dynamics modeling and virtual simulation technology to achieve the predictive design, and strive to achieve foreign level. In this paper, the author proposed a method of bearing design based on virtual simulation technology. The factors of bearing which affect the dynamic characteristics are considered, the process of design bearing based on virtual simulation is also considered. According to the different design parameters, the simulation results are used to verify the rationality, these can reduce the cost and improve the reliability. The virtual simulation technology is applied to design the 7016C angular contact ball bearing which used in aerospace area, and supported decision-making in structure design and data analyze. Finally, The feasibility of this method is verified by experiments..

  9. Analisis Pemasaran Ayam Ras Pedaging di Pasar Tradisional Kota Medan

    OpenAIRE

    Fachri, Yusrizal

    2017-01-01

    130306044 YUSRIZAL FACHRI, 2017. “Analisis Pemasaran Ayam Ras Pedaging di Pasar Tradisional Kota Medan”. Dibimbing oleh ARMYN HAKIM DAULAY dan NEVY DIANA HANAFI. Penelitian ini bertujuan untuk mengidentifikasi karakteristik lembaga pemasaran, bentuk saluran, fungsi pemasaran, dan menganalisis nilai tambah di lembaga-lembaga pemasaran ayam ras pedaging di pasar tradisional Kota Medan pada April sampai Mei 2017. Penelitian ini menggunakan data primer yang didapatkan dari observasi dan waw...

  10. Design and co-simulation of depth estimation using simulink HDL coder and modelsim

    International Nuclear Information System (INIS)

    Memon, F.; Memon, A.H.; Talpur, S.N.

    2016-01-01

    In this paper a novel VHDL design procedure of depth estimation algorithm using HDL (Hardware Description Language) Coder is presented. A framework is developed that takes depth estimation algorithm described in MATLAB as input and generates VHDL code, which dramatically decreases the time required to implement an application on FPGAs (Field Programmable Gate Arrays). In the first phase, design is carried out in MATLAB. Using HDL Coder, MATLAB floating- point design is converted to an efficient fixed-point design and generated VHDL Code and test-bench from fixed point MATLAB code. Further, the generated VHDL code of design is verified with co-simulation using Mentor Graphic ModelSim 10.3d software. Simulation results are presented which indicate that VHDL simulations match with the MATLAB simulations and confirm the efficiency of presented methodology. (author)

  11. RAS signalling in energy metabolism and rare human diseases.

    Science.gov (United States)

    Dard, L; Bellance, N; Lacombe, D; Rossignol, R

    2018-05-08

    The RAS pathway is a highly conserved cascade of protein-protein interactions and phosphorylation that is at the heart of signalling networks that govern proliferation, differentiation and cell survival. Recent findings indicate that the RAS pathway plays a role in the regulation of energy metabolism via the control of mitochondrial form and function but little is known on the participation of this effect in RAS-related rare human genetic diseases. Germline mutations that hyperactivate the RAS pathway have been discovered and linked to human developmental disorders that are known as RASopathies. Individuals with RASopathies, which are estimated to affect approximately 1/1000 human birth, share many overlapping characteristics, including cardiac malformations, short stature, neurocognitive impairment, craniofacial dysmorphy, cutaneous, musculoskeletal, and ocular abnormalities, hypotonia and a predisposition to developing cancer. Since the identification of the first RASopathy, type 1 neurofibromatosis (NF1), which is caused by the inactivation of neurofibromin 1, several other syndromes have been associated with mutations in the core components of the RAS-MAPK pathway. These syndromes include Noonan syndrome (NS), Noonan syndrome with multiple lentigines (NSML), which was formerly called LEOPARD syndrome, Costello syndrome (CS), cardio-facio-cutaneous syndrome (CFC), Legius syndrome (LS) and capillary malformation-arteriovenous malformation syndrome (CM-AVM). Here, we review current knowledge about the bioenergetics of the RASopathies and discuss the molecular control of energy homeostasis and mitochondrial physiology by the RAS pathway. Copyright © 2018 Elsevier B.V. All rights reserved.

  12. Ras oncogenes in oral cancer: the past 20 years.

    Science.gov (United States)

    Murugan, Avaniyapuram Kannan; Munirajan, Arasambattu Kannan; Tsuchida, Nobuo

    2012-05-01

    Oral squamous cell carcinoma (OSCC) of head and neck is associated with high morbidity and mortality in both Western and Asian countries. Several risk factors for the development of oral cancer are very well established, including tobacco chewing, betel quid, smoking, alcohol drinking and human papilloma virus (HPV) infection. Apart from these risk factors, many genetic factors such as oncogenes, tumor suppressor genes and regulatory genes are identified to involve in oral carcinogenesis with these risk factors dependent and independent manner. Ras is one of the most frequently genetically deregulated oncogene in oral cancer. In this review, we analyze the past 22years of literature on genetic alterations such as mutations and amplifications of the isoforms of the ras oncogene in oral cancer. Further, we addressed the isoform-specific role of the ras in oral carcinogenesis. We also discussed how targeting the Akt and MEK, downstream effectors of the PI3K/Akt and MAPK pathways, respectively, would probably pave the possible molecular therapeutic target for the ras driven tumorigenesis in oral cancer. Analysis of these ras isoforms may critically enlighten specific role of a particular ras isoform in oral carcinogenesis, enhance prognosis and pave the way for isoform-specific molecular targeted therapy in OSCC. Copyright © 2011 Elsevier Ltd. All rights reserved.

  13. Advanced Simulation Technology to Design Etching Process on CMOS Devices

    Science.gov (United States)

    Kuboi, Nobuyuki

    2015-09-01

    Prediction and control of plasma-induced damage is needed to mass-produce high performance CMOS devices. In particular, side-wall (SW) etching with low damage is a key process for the next generation of MOSFETs and FinFETs. To predict and control the damage, we have developed a SiN etching simulation technique for CHxFy/Ar/O2 plasma processes using a three-dimensional (3D) voxel model. This model includes new concepts for the gas transportation in the pattern, detailed surface reactions on the SiN reactive layer divided into several thin slabs and C-F polymer layer dependent on the H/N ratio, and use of ``smart voxels''. We successfully predicted the etching properties such as the etch rate, polymer layer thickness, and selectivity for Si, SiO2, and SiN films along with process variations and demonstrated the 3D damage distribution time-dependently during SW etching on MOSFETs and FinFETs. We confirmed that a large amount of Si damage was caused in the source/drain region with the passage of time in spite of the existing SiO2 layer of 15 nm in the over etch step and the Si fin having been directly damaged by a large amount of high energy H during the removal step of the parasitic fin spacer leading to Si fin damage to a depth of 14 to 18 nm. By analyzing the results of these simulations and our previous simulations, we found that it is important to carefully control the dose of high energy H, incident energy of H, polymer layer thickness, and over-etch time considering the effects of the pattern structure, chamber-wall condition, and wafer open area ratio. In collaboration with Masanaga Fukasawa and Tetsuya Tatsumi, Sony Corporation. We thank Mr. T. Shigetoshi and Mr. T. Kinoshita of Sony Corporation for their assistance with the experiments.

  14. Numerical simulation design of nuclear safety related expansion muffler

    International Nuclear Information System (INIS)

    Huang Bingchen; Shen Wei; Yang Tieming; Luo Jianping; Jing Feng

    2014-01-01

    According to the working conditions and technical requirements for pipe discharge muffler in passive nuclear power plant, the numerical simulation was used in analyzing sound transmission loss and fluid pressure loss of multi-section expansion muffler by finite element analysis (FEA) software ANSYS. The effect of different muffler structural parameters on sound transmission loss, passing frequency and pressure loss was also analyzed. Based on the analysis results, a reasonable combination of the muffler structural parameters was determined, and a pipe discharge muffler with good performance was obtained. (authors)

  15. Architectural design and simulation of a virtual memory

    Science.gov (United States)

    Kwok, G.; Chu, Y.

    1971-01-01

    Virtual memory is an imaginary main memory with a very large capacity which the programmer has at his disposal. It greatly contributes to the solution of the dynamic storage allocation problem. The architectural design of a virtual memory is presented which implements by hardware the idea of queuing and scheduling the page requests to a paging drum in such a way that the access of the paging drum is increased many times. With the design, an increase of up to 16 times in page transfer rate is achievable when the virtual memory is heavily loaded. This in turn makes feasible a great increase in the system throughput.

  16. Mechanical design and simulation of an automatized sample exchanger

    International Nuclear Information System (INIS)

    Lopez, Yon; Gora, Jimmy; Bedregal, Patricia; Hernandez, Yuri; Baltuano, Oscar; Gago, Javier

    2013-01-01

    The design of a turntable type sample exchanger for irradiation and with a capacity for up to 20 capsules was performed. Its function is the automatic sending of samples contained in polyethylene capsules, for irradiation in the grid position of the reactor core, using a pneumatic system and further analysis by neutron activation. This study shows the structural design analysis and calculations in selecting motors and actuators. This development will improve efficiency in the analysis, reducing the contribution of the workers and also the radiation exposure time. (authors).

  17. Massive parallel electromagnetic field simulation program JEMS-FDTD design and implementation on jasmin

    International Nuclear Information System (INIS)

    Li Hanyu; Zhou Haijing; Dong Zhiwei; Liao Cheng; Chang Lei; Cao Xiaolin; Xiao Li

    2010-01-01

    A large-scale parallel electromagnetic field simulation program JEMS-FDTD(J Electromagnetic Solver-Finite Difference Time Domain) is designed and implemented on JASMIN (J parallel Adaptive Structured Mesh applications INfrastructure). This program can simulate propagation, radiation, couple of electromagnetic field by solving Maxwell equations on structured mesh explicitly with FDTD method. JEMS-FDTD is able to simulate billion-mesh-scale problems on thousands of processors. In this article, the program is verified by simulating the radiation of an electric dipole. A beam waveguide is simulated to demonstrate the capability of large scale parallel computation. A parallel performance test indicates that a high parallel efficiency is obtained. (authors)

  18. A Simulation Platform To Model, Optimize And Design Wind Turbines. The Matlab/Simulink Toolbox

    Directory of Open Access Journals (Sweden)

    Anca Daniela HANSEN

    2002-12-01

    Full Text Available In the last years Matlab / Simulink® has become the most used software for modeling and simulation of dynamic systems. Wind energy conversion systems are for example such systems, containing subsystems with different ranges of the time constants: wind, turbine, generator, power electronics, transformer and grid. The electrical generator and the power converter need the smallest simulation step and therefore, these blocks decide the simulation speed. This paper presents a new and integrated simulation platform for modeling, optimizing and designing wind turbines. The platform contains different simulation tools: Matlab / Simulink - used as basic modeling tool, HAWC, DIgSilent and Saber.

  19. Flood analysis using HEC-RAS model: a case study for Hafr Al-Batin, Saudi Arabia

    Directory of Open Access Journals (Sweden)

    Al-Zahrani Muhammad

    2016-01-01

    Full Text Available Hafr Al-Batin is a Saudi Arabian city located in the northeastern part of the kingdom. The city lies in the dry valley of Wadi Al-Batin, part of Wadi Al-Rummah, which leads inland towards Medina and formerly emptied into the Arabian Gulf. Hafr Al-Batin is located in an area where three valleys meet, which makes the city under high risk of flooding, especially when intense rain occurs during short duration as in the case of arid and semi-arid regions. The yearly average rainfall intensity of Hafr Al-Baten is estimated to be 125 mm. Recently, extreme rainfall events occurred, generating flood water to flow from all valleys towards the city, causing serious damage to public and private properties. In this study, HEC-HMS and HEC-RAS models are used to simulate flood occurrence in the city. The results indicate that the average flow depths within the part of the main channel passing through Hafr Al-Batin city were 3.02 m, 3.26 m, 3.45 m, 3.76 m, 4.04 m and 4.34 m for the simulated 2, 5, 10, 25, 50 and 100-year design floods, respectively. Flood hazard maps are also generated to identify the areas within the city with high risk of flooding.

  20. Design and construction of ophthalmic simulators for clinical applications

    International Nuclear Information System (INIS)

    Sanchez, Andrea

    2006-01-01

    This work presents a calculational methodology for dose determination in human eye structures, such as: sclera, choroid, retina, lens, vitreous body, optic nerve and disc, and cornea, as well as tumor due to treatment to the eye plaques. A human eye model was constructed taking into consideration its main structural and dimension characteristics. Beyond that a mathematical model for the Co-60 and 1-125 plaques with all geometric details were built employing the MCNP-4C code. This model is able to calculate the axial and radial doses in any point of the eye and for each of its structures. An acrylic eye simulator was also built with the aim to obtain experimental results for the both model validations. This simulator is made of an acrylic sphere split into foils of 1 mm thickness which allow the introduction of a radiographic film to measure the axial and radial doses. The experimental data were used to validate the MCNP-4C results. The data from the mathematical model will serve as the basis to build a data bank for all the eye structures allowing different position and sizes of tumor as well as the replacement of all ophthalmic plaques used in the treatment. This data bank will be the principal part for the construction of a national software for the dose calculation and can be of great help for a reliable treatment system planning in radiotherapy/brachytherapy. (author)

  1. Design and simulation of double annular illumination mode for microlithography

    Science.gov (United States)

    Song, Qiang; Zhu, Jing; Yang, Baoxi; Liu, Lei; Wang, Jun; Huang, Huijie

    2013-08-01

    Methods of generating various illumination patterns remain as an attractive and important micro-optics research area for the development of resolution enhancement in advanced lithography system. In the current illumination system of lithography machine, off-axis illumination is widely used as an effective approach to enhance the resolution and increase the depth of focus (DOF). This paper proposes a novel illumination mode generation unit, which transform conventional mode to double annular shaped radial polarized (DARP) mode for improving the resolution of micro-lithography. Through LightToolsTM software simulation, double annular shaped mode is obtained from the proposed generation unit. The mathematical expressions of the radius variation of inner and outer rings are deduced. The impacts of conventional and dual concentric annular illumination pattern on critical dimension uniformity were simulated on an isolated line, square hole and corner. Lithography performance was compared between DARP illumination mode and corresponding single annular modes under critical dimension of 45nm. As a result, DARP illumination mode can improve the uniformity of aerial image at 45nm node through pitch varied in 300-500 nm to a certain extent.

  2. Unified Simulation and Analysis Framework for Deep Space Navigation Design

    Science.gov (United States)

    Anzalone, Evan; Chuang, Jason; Olsen, Carrie

    2013-01-01

    As the technology that enables advanced deep space autonomous navigation continues to develop and the requirements for such capability continues to grow, there is a clear need for a modular expandable simulation framework. This tool's purpose is to address multiple measurement and information sources in order to capture system capability. This is needed to analyze the capability of competing navigation systems as well as to develop system requirements, in order to determine its effect on the sizing of the integrated vehicle. The development for such a framework is built upon Model-Based Systems Engineering techniques to capture the architecture of the navigation system and possible state measurements and observations to feed into the simulation implementation structure. These models also allow a common environment for the capture of an increasingly complex operational architecture, involving multiple spacecraft, ground stations, and communication networks. In order to address these architectural developments, a framework of agent-based modules is implemented to capture the independent operations of individual spacecraft as well as the network interactions amongst spacecraft. This paper describes the development of this framework, and the modeling processes used to capture a deep space navigation system. Additionally, a sample implementation describing a concept of network-based navigation utilizing digitally transmitted data packets is described in detail. This developed package shows the capability of the modeling framework, including its modularity, analysis capabilities, and its unification back to the overall system requirements and definition.

  3. Designing and implementing nervous system simulations on LEGO robots.

    Science.gov (United States)

    Blustein, Daniel; Rosenthal, Nikolai; Ayers, Joseph

    2013-05-25

    We present a method to use the commercially available LEGO Mindstorms NXT robotics platform to test systems level neuroscience hypotheses. The first step of the method is to develop a nervous system simulation of specific reflexive behaviors of an appropriate model organism; here we use the American Lobster. Exteroceptive reflexes mediated by decussating (crossing) neural connections can explain an animal's taxis towards or away from a stimulus as described by Braitenberg and are particularly well suited for investigation using the NXT platform.(1) The nervous system simulation is programmed using LabVIEW software on the LEGO Mindstorms platform. Once the nervous system is tuned properly, behavioral experiments are run on the robot and on the animal under identical environmental conditions. By controlling the sensory milieu experienced by the specimens, differences in behavioral outputs can be observed. These differences may point to specific deficiencies in the nervous system model and serve to inform the iteration of the model for the particular behavior under study. This method allows for the experimental manipulation of electronic nervous systems and serves as a way to explore neuroscience hypotheses specifically regarding the neurophysiological basis of simple innate reflexive behaviors. The LEGO Mindstorms NXT kit provides an affordable and efficient platform on which to test preliminary biomimetic robot control schemes. The approach is also well suited for the high school classroom to serve as the foundation for a hands-on inquiry-based biorobotics curriculum.

  4. Design and validation of inert homemade explosive simulants for X-ray-based inspection systems

    Science.gov (United States)

    Faust, Anthony A.; Nacson, Sabatino; Koffler, Bruce; Bourbeau, Éric; Gagne, Louis; Laing, Robin; Anderson, C. J.

    2014-05-01

    Transport Canada (TC), the Canadian Armed Forces, and other public security agencies have an interest in the assessment of the potential utility of advanced explosives detection technologies to aid in the detection and interdiction of commercial grade, military grade, and homemade or improvised explosives (HME or IE). The availability of suitable, non-hazardous, non-toxic, explosive simulants is of concern when assessing the potential utility of such detection systems. Lack of simulants limits the training opportunities, and ultimately the detection probability, of security personnel using these systems. While simulants for commercial and military grade explosives are available for a wide variety of detection technologies, the design and production of materials to simulate improvised explosives has not kept pace with this emerging threat. Funded by TC and the Canadian Safety and Security Program, Defence Research and Development Canada (DRDC), Visiontec Systems, and Optosecurity engaged in an effort to develop inert, non-toxic Xray interrogation simulants for IE materials such as ammonium nitrate, potassium chlorate, and triacetone triperoxide. These simulants were designed to mimic key X-ray interrogation-relevant material properties of real improvised explosives, principally their bulk density and effective atomic number. Different forms of the simulants were produced and tested, simulating the different explosive threat formulations that could be encountered by front line security workers. These simulants comply with safety and stability requirements, and as best as possible match form and homogeneity. This paper outlines the research program, simulant design, and validation.

  5. Design and Numerical Simulation of Radial Inflow Turbine Volute

    Science.gov (United States)

    Shah, Samip P.; Channiwala, S. A.; Kulshreshtha, D. B.; Chaudhari, Gaurang

    2014-12-01

    The volute of a radial inflow turbine has to be designed to ensure that the desired rotor inlet conditions like absolute Mach number, flow angle etc. are attained. For the reasonable performance of vaneless volute turbine care has to be taken for reduction in losses at an appropriate flow angle at the rotor inlet, in the direction of volute, whose function is to convert gas energy into kinetic energy and direct the flow towards the rotor inlet at an appropriate flow angle with reduced losses. In literature it was found that the incompressible approaches failed to provide free vortex and uniform flow at rotor inlet for compressible flow regimes. So, this paper describes a non-dimensional design procedure for a vaneless turbine volute for compressible flow regime and investigates design parameters, such as the distribution of area ratio and radius ratio as a function of azimuth angle. The nondimensional design is converted in dimensional form for three different volute cross sections. A commercial computational fluid dynamics code is used to develop numerical models of three different volute cross sections. From the numerical models, losses generation in the different volutes are identified and compared. The maximum pressure loss coefficient for Trapezoidal cross section is 0.1075, for Bezier-trapezoidal cross section is 0.0677 and for circular cross section is 0.0438 near tongue region, which suggested that the circular cross section will give a better efficiency than other types of volute cross sections.

  6. Investigating the Impact of Using a CAD Simulation Tool on Students' Learning of Design Thinking

    Science.gov (United States)

    Taleyarkhan, Manaz; Dasgupta, Chandan; Garcia, John Mendoza; Magana, Alejandra J.

    2018-02-01

    Engineering design thinking is hard to teach and still harder to learn by novices primarily due to the undetermined nature of engineering problems that often results in multiple solutions. In this paper, we investigate the effect of teaching engineering design thinking to freshmen students by using a computer-aided Design (CAD) simulation software. We present a framework for characterizing different levels of engineering design thinking displayed by students who interacted with the CAD simulation software in the context of a collaborative assignment. This framework describes the presence of four levels of engineering design thinking—beginning designer, adept beginning designer, informed designer, adept informed designer. We present the characteristics associated with each of these four levels as they pertain to four engineering design strategies that students pursued in this study—understanding the design challenge, building knowledge, weighing options and making tradeoffs, and reflecting on the process. Students demonstrated significant improvements in two strategies—understanding the design challenge and building knowledge. We discuss the affordances of the CAD simulation tool along with the learning environment that potentially helped students move towards Adept informed designers while pursuing these design strategies.

  7. Primary Cosmic Rays Composition: Simulations and Detector Design

    International Nuclear Information System (INIS)

    Supanitsky, D.; Etchegoyen, A.; Medina, C.; Medina-Tanco, G.; Gomez Berisso, M.

    2007-01-01

    The Pierre Auger Observatory is a hybrid detector system for the detection of very high energy cosmic rays. A most difficult and important problem in these studies is the determination of the primary cosmic ray composition for which muon content in air showers appears to be one of the best parameters to discriminate between different composition types.Although the Pierre Auger surface detectors, which consist of water Cherenkov tanks, are sensitive to muon content they are not able to measure the number of muons directly. In this work we study using simulations the information that can be gained by adding muon detectors to the Auger surface detectors. We consider muon counters with two alternative areas

  8. Design and Study of Cognitive Network Physical Layer Simulation Platform

    Directory of Open Access Journals (Sweden)

    Yongli An

    2014-01-01

    Full Text Available Cognitive radio technology has received wide attention for its ability to sense and use idle frequency. IEEE 802.22 WRAN, the first to follow the standard in cognitive radio technology, is featured by spectrum sensing and wireless data transmission. As far as wireless transmission is concerned, the availability and implementation of a mature and robust physical layer algorithm are essential to high performance. For the physical layer of WRAN using OFDMA technology, this paper proposes a synchronization algorithm and at the same time provides a public platform for the improvement and verification of that new algorithm. The simulation results show that the performance of the platform is highly close to the theoretical value.

  9. System studies for micro grid design: modeling and simulation examples

    Energy Technology Data Exchange (ETDEWEB)

    Rosa, Arlei Lucas S. [Federal University of Juiz de Fora (UFJF), MG (Brazil); Ribeiro, Paulo F. [Calvin College, Grand Rapids, MI (United States). Electrical Engineering Dept.

    2009-07-01

    The search for new energy sources to replace or increase the existing power plant of the traditional system leads to changes in concepts of energy generation and consumption. In this context, the concept of Microgrid has been developed and opens the opportunity for local power generation. The Microgrid can operate connected to the existing distribution network, increasing the reliability and safety of the system. Control measures and electronics interface are taken to maintain the network as a single and strong unit to any perturbation. This paper presents the typical system studies required to investigate the performance of a Microgrid operating under different system condition (e.g. interconnected or isolated from the utility grid and under system disturbance). Load flow and electromagnetic transient studies are used for modeling and simulation of a typical Microgrid configuration. (author)

  10. High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site

    Science.gov (United States)

    Chavan, Tanmay S.; Jang, Hyunbum; Khavrutskii, Lyuba; Abraham, Sherwin J.; Banerjee, Avik; Freed, Benjamin C.; Johannessen, Liv; Tarasov, Sergey G.; Gaponenko, Vadim; Nussinov, Ruth; Tarasova, Nadya I.

    2015-01-01

    Ras proteins are small GTPases that act as signal transducers between cell surface receptors and several intracellular signaling cascades. They contain highly homologous catalytic domains and flexible C-terminal hypervariable regions (HVRs) that differ across Ras isoforms. KRAS is among the most frequently mutated oncogenes in human tumors. Surprisingly, we found that the C-terminal HVR of K-Ras4B, thought to minimally impact the catalytic domain, directly interacts with the active site of the protein. The interaction is almost 100-fold tighter with the GDP-bound than the GTP-bound protein. HVR binding interferes with Ras-Raf interaction, modulates binding to phospholipids, and slightly slows down nucleotide exchange. The data indicate that contrary to previously suggested models of K-Ras4B signaling, HVR plays essential roles in regulation of signaling. High affinity binding of short peptide analogs of HVR to K-Ras active site suggests that targeting this surface with inhibitory synthetic molecules for the therapy of KRAS-dependent tumors is feasible. PMID:26682817

  11. One-dimensional disk model simulation for klystron design

    International Nuclear Information System (INIS)

    Yonezawa, H.; Okazaki, Y.

    1984-05-01

    In 1982, one of the authors (Okazaki), of Toshiba Corporation, wrote a one-dimensional, rigid-disk model computer program to serve as a reliable design tool for the 150 MW klystron development project. This is an introductory note for the users of this program. While reviewing the so-called disk programs presently available, hypotheses such as gridded interaction gaps, a linear relation between phase and position, and so on, were found. These hypotheses bring serious limitations and uncertainties into the computational results. JPNDISK was developed to eliminate these defects, to follow the equations of motion as rigorously as possible, and to obtain self-consistent solutions for the gap voltages and the electron motion. Although some inaccuracy may be present in the relativistic region, JPNDISK, in its present form, seems a most suitable tool for klystron design; it is both easy and inexpensive to use

  12. Design of a transport calculation system for logging sondes simulation

    International Nuclear Information System (INIS)

    Marquez Damian, Jose Ignacio

    2005-01-01

    Analysis of available resources in earth crust is performed by different techniques, one of them is neutron logging. Design of sondes that are used to make such logging is supported by laboratory experiments as well as by numerical calculations.This work presents several calculation schemes, designed to simplify the task of whom has to planify such experiments or optimize parameters of this kind of sondes.These schemes use transport calculation codes, especially DaRT, TORT and MCNP, and cross section processing modules from SCALE system.Additionally a system for DaRT and TORT data postprocessing using OpenDX is presented.It allows scalar flux spatial distribution analysis, as wells as cross section condensation and reaction rates calculation

  13. A Simulation Tool for the Conceptual Design of Thermonuclear Pulsors

    International Nuclear Information System (INIS)

    Ramos, R.; Gonzalez, J.; Clausse, A.

    2003-01-01

    We worked with an effective model that calculates the neutron production of Plasma Focus devices.From experimental data we obtained different fitting functions for the model lumped parameters.By this way, we obtained a simple tool for neutron yield calculation.This tool is very useful at a conceptual design stage, because it can predict easily if a given PF device would be suitable for a certain application

  14. Flexible Multi-Body Spacecraft Simulator: Design, Construction, and Experiments

    Science.gov (United States)

    2017-12-01

    required analysis. The first step in applying Pontryagin’s Principle is writing the control Hamiltonian: ( , , , ) ( , , ) ( , , )TH x u t F x u t f...of holes allows the adapter plate to be fastened to the MBSS top plate. 26 The base and link are designed to be modular and expandable. The link...https://www.quanser.com/products/2-dof-serial-flexible-joint/ 79 INITIAL DISTRIBUTION LIST 1. Defense Technical Information Center Ft. Belvoir

  15. Rainwater catchment system design using simulated future climate data

    Science.gov (United States)

    Wallace, Corey D.; Bailey, Ryan T.; Arabi, Mazdak

    2015-10-01

    Rainwater harvesting techniques are used worldwide to augment potable water supply, provide water for small-scale irrigation practices, increase rainwater-use efficiency for sustained crop growth in arid and semi-arid regions, decrease urban stormwater flow volumes, and in general to relieve dependency on urban water resources cycles. A number of methods have been established in recent years to estimate reliability of rainwater catchment systems (RWCS) and thereby properly size the components (roof catchment area, storage tank size) of the system for a given climatic region. These methods typically use historical or stochastically-generated rainfall patterns to quantify system performance and optimally size the system, with the latter accounting for possible rainfall scenarios based on statistical relationships of historical rainfall patterns. To design RWCS systems that can sustainably meet water demand under future climate conditions, this paper introduces a method that employs climatic data from general circulation models (GCMs) to develop a suite of catchment area vs. storage size design curves that capture uncertainty in future climate scenarios. Monthly rainfall data for the 2010-2050 time period is statistically downscaled to daily values using a Markov chain algorithm, with results used only from GCMs that yield rainfall patterns that are statistically consistent with historical rainfall patterns. The process is demonstrated through application to two climatic regions of the Federated States of Micronesia (FSM) in the western Pacific, wherein the majority of the population relies on rainwater harvesting for potable water supply. Through the use of design curves, communities can provide household RWCS that achieve a certain degree of storage reliability. The method described herein can be applied generally to any geographic region. It can be used to first, assess the future performance of existing household systems; and second, to design or modify systems

  16. A study of human behavior simulation in architectural design for healthcare facilities.

    Science.gov (United States)

    Schaumann, Davide; Pilosof, Nirit Putievsky; Date, Kartikeya; Kalay, Yehuda E

    2016-01-01

    Current tools and methods in architectural design do not allow predicting and evaluating how people will use designed environments before their actual realization. To investigate how computational simulation can help in evaluating design proposals as far as their use by people is concerned. Simulation of a medicine distribution procedure in a general hospital facility, while accounting for serendipitous social interactions made possible by the presence of different users in the same space, at the same time. The simulation shows how use patterns are influenced by the social and physical context in which actors are situated, and demonstrates the significance of the proposed method of evaluating hospital designs before construction. The system allows simulating use patterns with different degrees of complexity, and enables architects to ask new types of questions related to the interactions between people and physical settings.

  17. Advanced High and Low Fidelity HPC Simulations of FCS Concept Designs for Dynamic Systems

    National Research Council Canada - National Science Library

    Sandhu, S. S; Kanapady, R; Tamma, K. K

    2004-01-01

    ...) resources of many Army initiatives. In this paper we present a new and advanced HPC based rigid and flexible modeling and simulation technology capable of adaptive high/low fidelity modeling that is useful in the initial design concept...

  18. Using Explorative Simulation to Drive User-Centered Design and IT-Development in Healthcare

    DEFF Research Database (Denmark)

    Edwards, Kasper; Thommesen, Jacob; Broberg, Ole

    2012-01-01

    We describe a method involving user-system simulation to drive rapid development and evaluation of layout, organization or information technology in healthcare. The method has been developed, tested and refined in three sub-projects in the Capital Region of Denmark. The overall goal of the project...... was to validate such a development method in a two-year project (2010-11). Explorative simulation is primarily based on approaches in design and usability engineering and simulation-based training in healthcare, and involves end-users and designers or engineers in a collaborative exploration of design solution...... can gain insight into the healthcare work practice and design applications accordingly - Theories and new ideas can be readily transformed to into the simulated world where they are explored and quickly rejected or used further - A very cost-effective approach to innovation....

  19. Nonlinear Aerodynamics-Structure Time Simulation for HALE Aircraft Design/Analysis, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Time simulation of a nonlinear aerodynamics model (NA) developed at Virginia Tech coupled with a nonlinear structure model (NS) is proposed as a design/analysis...

  20. Collaborative design for embedded systems co-modelling and co-simulation

    CERN Document Server

    Fitzgerald, John; Verhoef, Marcel

    2014-01-01

    This book presents a framework that allows the very different kinds of design models - discrete-event models of software and continuous time models of the physical environment - to be analyzed and simulated jointly, based on common scenarios.

  1. Using a Competitive Approach to Improve Military Simulation Artificial Intelligence Design

    National Research Council Canada - National Science Library

    Stoykov, Sevdalin

    2008-01-01

    ...) design can lead to improvement of the AI solutions used in military simulations. To demonstrate the potential of the competitive approach, ORTS, a real-time strategy game engine, and its competition setup are used...

  2. Regulation of an H-ras-related transcript by parathyroid hormone in rat osteosarcoma cells

    Science.gov (United States)

    Scott, D. K.; Weaver, W. R.; Clohisy, J. C.; Brakenhoff, K. D.; Kahn, A. J.; Partridge, N. C.

    1992-01-01

    The rat osteosarcoma cell line UMR 106-01 is a commonly used model system for the study of osteoblast function. However, it also expresses a phenotype characteristic of transformed cells. To test whether the latter could be accounted for by aberrant oncogene expression, we probed Northern blots of UMR and other osteoblastic cells with a panel of oncogene probes. These blots, when probed with a cDNA specific for v-H-ras, revealed a 7.0-kilobase (kb) H-ras-related transcript (designated HRRT) in UMR 106-01 cells that was not expressed in other osteoblastic cells. Osteoblast-enriched calvarial cells expressed the typical 1.1-kb H-ras mRNA, which was absent in UMR cells. Additionally, Western blots of lysates of UMR cells documented the presence of three proteins immunologically related to H-rasp21. To determine whether HRRT represented a recombinant retrovirus product, Northern blots were probed with a cDNA specific for the highly conserved gag-pol region of Moloney murine leukemia virus. These blots showed parallel cross-reactivity with an apparently identical transcript of 7.0 kb. The 7.0-kb transcripts detected by both v-H-ras and gag-pol probes declined to the same extent after treatment with concentrations of PTH known to inhibit proliferation of these cells. PTH regulated the abundance of HRRT in a time- and dose-dependent manner, with greatest repression of the transcript after 8 h of treatment with 10(-8) M PTH. The decrease in HRRT could not be completely accounted for by changes in transcriptional activity, as determined by nuclear run-on assays.(ABSTRACT TRUNCATED AT 250 WORDS).

  3. Simulation to support sustainable HVAC design for two historical buildings in Prague

    NARCIS (Netherlands)

    Bartak, M.; Drkal, F.; Hensen, J.L.M.; Lain, M.; Matuska, J.; Schwarzer, J.; Sourek, B.

    2001-01-01

    This paper attempts to outline the current state-of-the-art in the Czech Republic regarding the use of integrated building performance simulation as a design tool. Integrated modeling and simulation of buildings is illustrated by means of two recent studies for conversion of historical buildings (a

  4. Design and Developmental Research on the VV&A of Complex Simulation System

    Directory of Open Access Journals (Sweden)

    Liu Li

    2016-01-01

    Full Text Available The Verification, Validation and Accreditation (VV&A of a complex simulation system is a complex systems engineering. Based on the brief introduction to the concept of VV&A, this paper puts forward its design principles, approaches and basic contents, expounds the typical developing process and predicts its up-to-date technology developing trend of complex simulation system.

  5. Simulation as a key to success in power supply design and development

    Energy Technology Data Exchange (ETDEWEB)

    Suur-Askola, S.; Laasonen, M.; Maeki, J. [Efore Muuntolaite Oy, Vantaa (Finland)

    1997-12-31

    This paper describes the design and development process of a power supply by using simulation methods. The simulation principles and results of a 40W power supply are provided including EMI, voltage and current rating verification as well as power loss approximation. (orig.) 8 refs.

  6. Uncertainty and sensitivity analysis in building performance simulation for decision support and design optimization

    NARCIS (Netherlands)

    Hopfe, C.J.

    2009-01-01

    Building performance simulation (BPS) uses computer-based models that cover performance aspects such as energy consumption and thermal comfort in buildings. The uptake of BPS in current building design projects is limited. Although there is a large number of building simulation tools available, the

  7. Use of Computer Simulation in Designing and Evaluating a Proposed Rough Mill for Furniture Interior Parts

    Science.gov (United States)

    Philip A. Araman

    1977-01-01

    The design of a rough mill for the production of interior furniture parts is used to illustrate a simulation technique for analyzing and evaluating established and proposed sequential production systems. Distributions representing the real-world random characteristics of lumber, equipment feed speeds and delay times are programmed into the simulation. An example is...

  8. Early decision support for net zero energy buildings design using building performance simulation

    NARCIS (Netherlands)

    Attia, S.G.; Gratia, E.; De Herde, A.; Hensen, J.L.M.

    2013-01-01

    This paper aims to investigate the use of building performance simulation tools as a method of informing the design decision of NZEBs. The aim of this study is to evaluate the effect of a simulation-based decision aid, ZEBO, on informed decision-making using sensitivity analysis. The objective is to

  9. Designing efficient nitrous oxide sampling strategies in agroecosystems using simulation models

    Science.gov (United States)

    Debasish Saha; Armen R. Kemanian; Benjamin M. Rau; Paul R. Adler; Felipe Montes

    2017-01-01

    Annual cumulative soil nitrous oxide (N2O) emissions calculated from discrete chamber-based flux measurements have unknown uncertainty. We used outputs from simulations obtained with an agroecosystem model to design sampling strategies that yield accurate cumulative N2O flux estimates with a known uncertainty level. Daily soil N2O fluxes were simulated for Ames, IA (...

  10. Integration of distributed system simulation tools for a holistic approach to integrated building and system design

    NARCIS (Netherlands)

    Radosevic, M.; Hensen, J.L.M.; Wijsman, A.J.T.M.; Hensen, J.L.M.; Lain, M.

    2004-01-01

    Advanced architectural developments require an integrated approach to design where simulation tools available today deal. only with a small subset of the overall problem. The aim of this study is to enable run time exchange of necessary data at suitable frequency between different simulation

  11. Design and Application of Interactive Simulations in Problem-Solving in University-Level Physics Education

    Science.gov (United States)

    Ceberio, Mikel; Almudí, José Manuel; Franco, Ángel

    2016-01-01

    In recent years, interactive computer simulations have been progressively integrated in the teaching of the sciences and have contributed significant improvements in the teaching-learning process. Practicing problem-solving is a key factor in science and engineering education. The aim of this study was to design simulation-based problem-solving…

  12. Computer simulations for state-of-the-art engineering design of a commercial building in Prague

    NARCIS (Netherlands)

    Bartak, M.; Drkal, F.; Hensen, J.L.M.; Lain, M.; Schwarzer, J.

    2003-01-01

    The paper describes the computer simulation work, which was carried out to support the engineering design team of the Luxembourg Plaza building development in Prague. The simulations for this study were based on (1) energy balance models covering the whole building for heating and cooling load

  13. Students as Simulation Designers and Developers--Using Computer Simulations for Teaching Boundary Layer Processes.

    Science.gov (United States)

    Johnson, Tristan E.; Clayson, Carol Anne

    As technology developments seek to improve learning, researchers, developers, and educators seek to understand how technological properties impact performance. This paper delineates how a traditional science course is enhanced through the use of simulation projects directed by the students themselves as a means to increase their level of knowledge…

  14. Bio-Inspired Multi-Functional Drug Transport Design Concept and Simulations.

    Science.gov (United States)

    Pidaparti, Ramana M; Cartin, Charles; Su, Guoguang

    2017-04-25

    In this study, we developed a microdevice concept for drug/fluidic transport taking an inspiration from supramolecular motor found in biological cells. Specifically, idealized multi-functional design geometry (nozzle/diffuser/nozzle) was developed for (i) fluidic/particle transport; (ii) particle separation; and (iii) droplet generation. Several design simulations were conducted to demonstrate the working principles of the multi-functional device. The design simulations illustrate that the proposed design concept is feasible for multi-functionality. However, further experimentation and optimization studies are needed to fully evaluate the multifunctional device concept for multiple applications.

  15. A Simulation Modeling Approach Method Focused on the Refrigerated Warehouses Using Design of Experiment

    Science.gov (United States)

    Cho, G. S.

    2017-09-01

    For performance optimization of Refrigerated Warehouses, design parameters are selected based on the physical parameters such as number of equipment and aisles, speeds of forklift for ease of modification. This paper provides a comprehensive framework approach for the system design of Refrigerated Warehouses. We propose a modeling approach which aims at the simulation optimization so as to meet required design specifications using the Design of Experiment (DOE) and analyze a simulation model using integrated aspect-oriented modeling approach (i-AOMA). As a result, this suggested method can evaluate the performance of a variety of Refrigerated Warehouses operations.

  16. Design of an Indoor Sonic Boom Simulator at NASA Langley Research Center

    Science.gov (United States)

    Klos, Jacob; Sullivan, Brenda M.; Shepherd, Kevin P.

    2008-01-01

    Construction of a simulator to recreate the soundscape inside residential buildings exposed to sonic booms is scheduled to start during the summer of 2008 at NASA Langley Research Center. The new facility should be complete by the end of the year. The design of the simulator allows independent control of several factors that create the indoor soundscape. Variables that will be isolated include such factors as boom duration, overpressure, rise time, spectral shape, level of rattle, level of squeak, source of rattle and squeak, level of vibration and source of vibration. Test subjects inside the simulator will be asked to judge the simulated soundscape, which will represent realistic indoor boom exposure. Ultimately, this simulator will be used to develop a functional relationship between human response and the sound characteristics creating the indoor soundscape. A conceptual design has been developed by NASA personnel, and is currently being vetted through small-scale risk reduction tests that are being performed in-house. The purpose of this document is to introduce the conceptual design, identify how the indoor response will be simulated, briefly outline some of the risk reduction tests that have been completed to vet the design, and discuss the impact of these tests on the simulator design.

  17. Analyzing and designing object-oriented missile simulations with concurrency

    Science.gov (United States)

    Randorf, Jeffrey Allen

    2000-11-01

    A software object model for the six degree-of-freedom missile modeling domain is presented. As a precursor, a domain analysis of the missile modeling domain was started, based on the Feature-Oriented Domain Analysis (FODA) technique described by the Software Engineering Institute (SEI). It was subsequently determined the FODA methodology is functionally equivalent to the Object Modeling Technique. The analysis used legacy software documentation and code from the ENDOSIM, KDEC, and TFrames 6-DOF modeling tools, including other technical literature. The SEI Object Connection Architecture (OCA) was the template for designing the object model. Three variants of the OCA were considered---a reference structure, a recursive structure, and a reference structure with augmentation for flight vehicle modeling. The reference OCA design option was chosen for maintaining simplicity while not compromising the expressive power of the OMT model. The missile architecture was then analyzed for potential areas of concurrent computing. It was shown how protected objects could be used for data passing between OCA object managers, allowing concurrent access without changing the OCA reference design intent or structure. The implementation language was the 1995 release of Ada. OCA software components were shown how to be expressed as Ada child packages. While acceleration of several low level and other high operations level are possible on proper hardware, there was a 33% degradation of 4th order Runge-Kutta integrator performance of two simultaneous ordinary differential equations using Ada tasking on a single processor machine. The Defense Department's High Level Architecture was introduced and explained in context with the OCA. It was shown the HLA and OCA were not mutually exclusive architectures, but complimentary. HLA was shown as an interoperability solution, with the OCA as an architectural vehicle for software reuse. Further directions for implementing a 6-DOF missile modeling

  18. Design & simulation of a 800 kV dynamitron accelerator by CST studio

    Directory of Open Access Journals (Sweden)

    A M Aghayan

    2015-09-01

    Full Text Available Nowadays, middle energy electrostatic accelerators in industries are widely used due to their high efficiency and low cost compared with other types of accelerators. In this paper, the importance and applications of electrostatic accelerators with 800 keV energy are studied. Design and simulation of capacitive coupling of a dynamitron accelerator is proposed. Furthermore, accelerating tube are designed and simulated by means of CST Suit Studio

  19. Modelling physics detectors in a computer aided design system for simulation purposes

    International Nuclear Information System (INIS)

    Ahvenainen, J.; Oksakivi, T.; Vuoskoski, J.

    1995-01-01

    The possibility of transferring physics detector models from computer aided design systems into physics simulation packages like GEANT is receiving increasing attention. The problem of exporting detector models constructed in CAD systems into GEANT is well known. We discuss the problem and describe an application, called DDT, which allows one to design detector models in a CAD system and then transfer the models into GEANT for simulation purposes. (orig.)

  20. Configuration Method Design for Reconfigurable Manufacturing System with the aid of Plant Simulation

    DEFF Research Database (Denmark)

    Li, Yang; Zhang, Shuai; Bilberg, Arne

    2014-01-01

    A new Reconfigurable Manufacturing System structure has been recently designed by a large consumer goods manufacturer in Europe, aiming to balance the performance of productivity and flexibility. This article shows an exploratory research on the (re)configuration procedure of the new RMS structure....... Following the procedure which is designed in this paper, the (re)configuration of RMS can be managed as part of the daily operation with the help of computer simulation. Keywords: Plant Simulation, Tecnomatix, Reconfigurable Manufacturing System, modular manufacturing....

  1. Design and simulation of a plant control system for a GCFR demonstration plant

    International Nuclear Information System (INIS)

    Estrine, E.A.; Greiner, H.G.

    1980-02-01

    A plant control system is being designed for a 300 MW(e) Gas Cooled Fast Breeder Reactor (GCFR) demonstration plant. Control analysis is being performed as an integral part of the plant design process to ensure that control requirements are satisfied as the plant design evolves. Plant models and simulations are being developed to generate information necessary to further define control system requirements for subsequent plant design iterations

  2. Design and Realization of Avionics Integration Simulation System Based on RTX

    Directory of Open Access Journals (Sweden)

    Wang Liang

    2016-01-01

    Full Text Available Aircraft avionics system becoming more and more complicated, it is too hard to test and verify real avionics systems. A design and realization method of avionics integration simulation system based on RTX was brought forward to resolve the problem. In this simulation system, computer software and hardware resources were utilized entirely. All kinds of aircraft avionics system HIL (hardware-in-loop simulations can be implemented in this platform. The simulation method provided the technical foundation of testing and verifying real avionics system. The research has recorded valuable data using the newly-developed method. The experiment results prove that the avionics integration simulation system was used well in some helicopter avionics HIL simulation experiment. The simulation experiment results provided the necessary judgment foundation for the helicopter real avionics system verification.

  3. SImulated Dodewaard ASsembly: Developments in loop-design

    International Nuclear Information System (INIS)

    Graaf, R. van de.

    1992-03-01

    A computer program was written to calculate void-fraction, flow rate, system circulation time and pressure drops for SIDAS under natural circulation conditions. In this program the thermohydraulic behaviour of the loop is simulated. Taking into account for the large uncertainty in two-phase frictional pressure drops, the chimney length is calculated, together with the length of the tubes which connect the downcomer at assembly height with the assembly inlet in a roundabout way. Tube diameter is chosen such that the frictional pressure losses are negligible. Using the results, it was decided to construct the chimney 'telescopically' (consisting of a fixed part and a movable part) in order to influence the driving force. Calculations of the enthalpy of the condensed vapour flow for various system conditions have shown that it is impractical to use this flow to lower the temperature of the total downcomer flow at the necessary subcooling temperature. It is therefore decided to use the condensor flow only for lowering the total downcomer flow enthalpy at saturation enthalpy and to establish the necessary subcooling separately by cooling of the flow in the connecting tubes. (orig.)

  4. Conversion of microalgae to jet fuel: process design and simulation.

    Science.gov (United States)

    Wang, Hui-Yuan; Bluck, David; Van Wie, Bernard J

    2014-09-01

    Microalgae's aquatic, non-edible, highly genetically modifiable nature and fast growth rate are considered ideal for biomass conversion to liquid fuels providing promise for future shortages in fossil fuels and for reducing greenhouse gas and pollutant emissions from combustion. We demonstrate adaptability of PRO/II software by simulating a microalgae photo-bio-reactor and thermolysis with fixed conversion isothermal reactors adding a heat exchanger for thermolysis. We model a cooling tower and gas floatation with zero-duty flash drums adding solids removal for floatation. Properties data are from PRO/II's thermodynamic data manager. Hydrotreating is analyzed within PRO/II's case study option, made subject to Jet B fuel constraints, and we determine an optimal 6.8% bioleum bypass ratio, 230°C hydrotreater temperature, and 20:1 bottoms to overhead distillation ratio. Process economic feasibility occurs if cheap CO2, H2O and nutrient resources are available, along with solar energy and energy from byproduct combustion, and hydrotreater H2 from product reforming. Copyright © 2014 Elsevier Ltd. All rights reserved.

  5. Synthetic tracked aperture ultrasound imaging: design, simulation, and experimental evaluation.

    Science.gov (United States)

    Zhang, Haichong K; Cheng, Alexis; Bottenus, Nick; Guo, Xiaoyu; Trahey, Gregg E; Boctor, Emad M

    2016-04-01

    Ultrasonography is a widely used imaging modality to visualize anatomical structures due to its low cost and ease of use; however, it is challenging to acquire acceptable image quality in deep tissue. Synthetic aperture (SA) is a technique used to increase image resolution by synthesizing information from multiple subapertures, but the resolution improvement is limited by the physical size of the array transducer. With a large F-number, it is difficult to achieve high resolution in deep regions without extending the effective aperture size. We propose a method to extend the available aperture size for SA-called synthetic tracked aperture ultrasound (STRATUS) imaging-by sweeping an ultrasound transducer while tracking its orientation and location. Tracking information of the ultrasound probe is used to synthesize the signals received at different positions. Considering the practical implementation, we estimated the effect of tracking and ultrasound calibration error to the quality of the final beamformed image through simulation. In addition, to experimentally validate this approach, a 6 degree-of-freedom robot arm was used as a mechanical tracker to hold an ultrasound transducer and to apply in-plane lateral translational motion. Results indicate that STRATUS imaging with robotic tracking has the potential to improve ultrasound image quality.

  6. SImulated Dodewaard ASsembly: Developments in loop-design

    Energy Technology Data Exchange (ETDEWEB)

    Graaf, R van de

    1992-03-01

    A computer program was written to calculate void-fraction, flow rate, system circulation time and pressure drops for SIDAS under natural circulation conditions. In this program the thermohydraulic behaviour of the loop is simulated. Taking into account for the large uncertainty in two-phase frictional pressure drops, the chimney length is calculated, together with the length of the tubes which connect the downcomer at assembly height with the assembly inlet in a roundabout way. Tube diameter is chosen such that the frictional pressure losses are negligible. Using the results, it was decided to construct the chimney `telescopically` (consisting of a fixed part and a movable part) in order to influence the driving force. Calculations of the enthalpy of the condensed vapour flow for various system conditions have shown that it is impractical to use this flow to lower the temperature of the total downcomer flow at the necessary subcooling temperature. It is therefore decided to use the condensor flow only for lowering the total downcomer flow enthalpy at saturation enthalpy and to establish the necessary subcooling separately by cooling of the flow in the connecting tubes. (orig.).

  7. Simulation methods to estimate design power: an overview for applied research.

    Science.gov (United States)

    Arnold, Benjamin F; Hogan, Daniel R; Colford, John M; Hubbard, Alan E

    2011-06-20

    Estimating the required sample size and statistical power for a study is an integral part of study design. For standard designs, power equations provide an efficient solution to the problem, but they are unavailable for many complex study designs that arise in practice. For such complex study designs, computer simulation is a useful alternative for estimating study power. Although this approach is well known among statisticians, in our experience many epidemiologists and social scientists are unfamiliar with the technique. This article aims to address this knowledge gap. We review an approach to estimate study power for individual- or cluster-randomized designs using computer simulation. This flexible approach arises naturally from the model used to derive conventional power equations, but extends those methods to accommodate arbitrarily complex designs. The method is universally applicable to a broad range of designs and outcomes, and we present the material in a way that is approachable for quantitative, applied researchers. We illustrate the method using two examples (one simple, one complex) based on sanitation and nutritional interventions to improve child growth. We first show how simulation reproduces conventional power estimates for simple randomized designs over a broad range of sample scenarios to familiarize the reader with the approach. We then demonstrate how to extend the simulation approach to more complex designs. Finally, we discuss extensions to the examples in the article, and provide computer code to efficiently run the example simulations in both R and Stata. Simulation methods offer a flexible option to estimate statistical power for standard and non-traditional study designs and parameters of interest. The approach we have described is universally applicable for evaluating study designs used in epidemiologic and social science research.

  8. Design and simulation of origami structures with smooth folds.

    Science.gov (United States)

    Peraza Hernandez, E A; Hartl, D J; Lagoudas, D C

    2017-04-01

    Origami has enabled new approaches to the fabrication and functionality of multiple structures. Current methods for origami design are restricted to the idealization of folds as creases of zeroth-order geometric continuity. Such an idealization is not proper for origami structures of non-negligible fold thickness or maximum curvature at the folds restricted by material limitations. For such structures, folds are not properly represented as creases but rather as bent regions of higher-order geometric continuity. Such fold regions of arbitrary order of continuity are termed as smooth folds . This paper presents a method for solving the following origami design problem: given a goal shape represented as a polygonal mesh (termed as the goal mesh ), find the geometry of a single planar sheet, its pattern of smooth folds, and the history of folding motion allowing the sheet to approximate the goal mesh. The parametrization of the planar sheet and the constraints that allow for a valid pattern of smooth folds are presented. The method is tested against various goal meshes having diverse geometries. The results show that every determined sheet approximates its corresponding goal mesh in a known folded configuration having fold angles obtained from the geometry of the goal mesh.

  9. Reactor controller design using genetic algorithm with simulated annealing

    International Nuclear Information System (INIS)

    Willjuice Iruthyarajan, M.

    2012-01-01

    Many reactor control design work, specifically the problem of synthesis and optimization of reactor networks involving the classical reaction schemes was studied, considering a superstructure formed by a CSTR and a PFR and their possible arrangements. A genetic algorithm was proposed, together with a systematic procedure. Two case studies were solved with the proposed systematic. Both of them present similar results than the published in the literature. The first case studied was the Trambouze reaction scheme. Although selectivity values are smaller then the values published in the referred papers, the reactors system combined volume is always minor them the other ones. The second case studied was the Van de Vusse reaction scheme. In this case, the obtained value for the total volume is always minor then the considered papers. One can conclude that when compared with the other works presented in the literature results are compatible and very interesting. The developed algorithms can be used as a good alternative for reactor networks design and optimization problem

  10. Design of PID Controller Simulator based on Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    Fahri VATANSEVER

    2013-08-01

    Full Text Available PID (Proportional Integral and Derivative controllers take an important place in the field of system controlling. Various methods such as Ziegler-Nichols, Cohen-Coon, Chien Hrones Reswick (CHR and Wang-Juang-Chan are available for the design of such controllers benefiting from the system time and frequency domain data. These controllers are in compliance with system properties under certain criteria suitable to the system. Genetic algorithms have become widely used in control system applications in parallel to the advances in the field of computer and artificial intelligence. In this study, PID controller designs have been carried out by means of classical methods and genetic algorithms and comparative results have been analyzed. For this purpose, a graphical user interface program which can be used for educational purpose has been developed. For the definite (entered transfer functions, the suitable P, PI and PID controller coefficients have calculated by both classical methods and genetic algorithms and many parameters and responses of the systems have been compared and presented numerically and graphically

  11. Simulation-aided design and fabrication of nanoprobes for scanning probe microscopy

    International Nuclear Information System (INIS)

    Liu, Bernard Haochih; Chang, Day-Bin

    2011-01-01

    We proposed and demonstrated a flexible and effective method to design and fabricate scanning probes for atomic force microscopy applications. Computer simulations were adopted to evaluate design specifications and desired performance of atomic force microscope (AFM) probes; the fabrication processes were guided by feedback from simulation results. Through design-simulation-fabrication iterations, tipless cantilevers and tapping mode probes were successfully made with errors as low as 2% in designed resonant frequencies. For tapping mode probes, the probe tip apex achieved a 10 nm radius of curvature without additional sharpening steps; tilt-compensated probes were also fabricated for better scanning performance. This method provides AFM users improved probe quality and practical guidelines for customized probes, which can support the development of novel scanning probe microscopy (SPM) applications. -- Research highlights: → We developed a design-simulation-fabrication strategy for customized AFM/SPM probes and demonstrated the results of tipless cantilever, sharpened probe tip, and tilt-compensated probe. → This simulation-aided method improved the geometry control and performance prediction of AFM probes; the error in resonant frequency was reduced to ∼2%. → Integration of simulation in design and fabrication of AFM probes expedites development of new probes and consequently promotes novel SPM applications.

  12. Performance analyses of naval ships based on engineering level of simulation at the initial design stage

    Directory of Open Access Journals (Sweden)

    Dong-Hoon Jeong

    2017-07-01

    Full Text Available Naval ships are assigned many and varied missions. Their performance is critical for mission success, and depends on the specifications of the components. This is why performance analyses of naval ships are required at the initial design stage. Since the design and construction of naval ships take a very long time and incurs a huge cost, Modeling and Simulation (M & S is an effective method for performance analyses. Thus in this study, a simulation core is proposed to analyze the performance of naval ships considering their specifications. This simulation core can perform the engineering level of simulations, considering the mathematical models for naval ships, such as maneuvering equations and passive sonar equations. Also, the simulation models of the simulation core follow Discrete EVent system Specification (DEVS and Discrete Time System Specification (DTSS formalisms, so that simulations can progress over discrete events and discrete times. In addition, applying DEVS and DTSS formalisms makes the structure of simulation models flexible and reusable. To verify the applicability of this simulation core, such a simulation core was applied to simulations for the performance analyses of a submarine in an Anti-SUrface Warfare (ASUW mission. These simulations were composed of two scenarios. The first scenario of submarine diving carried out maneuvering performance analysis by analyzing the pitch angle variation and depth variation of the submarine over time. The second scenario of submarine detection carried out detection performance analysis by analyzing how well the sonar of the submarine resolves adjacent targets. The results of these simulations ensure that the simulation core of this study could be applied to the performance analyses of naval ships considering their specifications.

  13. Design, simulation, fabrication, and characterization of MEMS vibration energy harvesters

    Science.gov (United States)

    Oxaal, John

    Energy harvesting from ambient sources has been a longtime goal for microsystem engineers. The energy available from ambient sources is substantial and could be used to power wireless micro devices, making them fully autonomous. Self-powered wireless sensors could have many applications in for autonomous monitoring of residential, commercial, industrial, geological, or biological environments. Ambient vibrations are of particular interest for energy harvesting as they are ubiquitous and have ample kinetic energy. In this work a MEMS device for vibration energy harvesting using a variable capacitor structure is presented. The nonlinear electromechanical dynamics of a gap-closing type structure is experimentally studied. Important experimental considerations such as the importance of reducing off-axis vibration during testing, characterization methods, dust contamination, and the effect of grounding on parasitic capacitance are discussed. A comprehensive physics based model is developed and validated with two different microfabricated devices. To achieve maximal power, devices with high aspect ratio electrodes and a novel two-level stopper system are designed and fabricated. The maximum achieved power from the MEMS device when driven by sinusoidal vibrations was 3.38 muW. Vibrations from HVAC air ducts, which have a primary frequency of 65 Hz and amplitude of 155 mgrms, are targeted as the vibration source and devices are designed for maximal power harvesting potential at those conditions. Harvesting from the air ducts, the devices reached 118 nW of power. When normalized to the operating conditions, the best figure of merit of the devices tested was an order of magnitude above state-of-the-art of the devices (1.24E-6).

  14. A Novel Simulation Technician Laboratory Design: Results of a Survey-Based Study.

    Science.gov (United States)

    Ahmed, Rami; Hughes, Patrick G; Friedl, Ed; Ortiz Figueroa, Fabiana; Cepeda Brito, Jose R; Frey, Jennifer; Birmingham, Lauren E; Atkinson, Steven Scott

    2016-03-16

    OBJECTIVE : The purpose of this study was to elicit feedback from simulation technicians prior to developing the first simulation technician-specific simulation laboratory in Akron, OH. Simulation technicians serve a vital role in simulation centers within hospitals/health centers around the world. The first simulation technician degree program in the US has been approved in Akron, OH. To satisfy the requirements of this program and to meet the needs of this special audience of learners, a customized simulation lab is essential. A web-based survey was circulated to simulation technicians prior to completion of the lab for the new program. The survey consisted of questions aimed at identifying structural and functional design elements of a novel simulation center for the training of simulation technicians. Quantitative methods were utilized to analyze data. Over 90% of technicians (n=65) think that a lab designed explicitly for the training of technicians is novel and beneficial. Approximately 75% of respondents think that the space provided appropriate audiovisual (AV) infrastructure and space to evaluate the ability of technicians to be independent. The respondents think that the lab needed more storage space, visualization space for a large number of students, and more space in the technical/repair area. CONCLUSIONS : A space designed for the training of simulation technicians was considered to be beneficial. This laboratory requires distinct space for technical repair, adequate bench space for the maintenance and repair of simulators, an appropriate AV infrastructure, and space to evaluate the ability of technicians to be independent.

  15. CLARREO shortwave observing system simulation experiments of the twenty-first century: Simulator design and implementation

    Energy Technology Data Exchange (ETDEWEB)

    Feldman, D.R.; Algieri, C.A.; Ong, J.R.; Collins, W.D.

    2011-04-01

    Projected changes in the Earth system will likely be manifested in changes in reflected solar radiation. This paper introduces an operational Observational System Simulation Experiment (OSSE) to calculate the signals of future climate forcings and feedbacks in top-of-atmosphere reflectance spectra. The OSSE combines simulations from the Intergovernmental Panel on Climate Change (IPCC) Fourth Assessment Report for the NCAR Community Climate System Model (CCSM) with the MODTRAN radiative transfer code to calculate reflectance spectra for simulations of current and future climatic conditions over the 21st century. The OSSE produces narrowband reflectances and broadband fluxes, the latter of which have been extensively validated against archived CCSM results. The shortwave reflectance spectra contain atmospheric features including signals from water vapor, liquid and ice clouds, and aerosols. The spectra are also strongly influenced by the surface bidirectional reflectance properties of predicted snow and sea ice and the climatological seasonal cycles of vegetation. By comparing and contrasting simulated reflectance spectra based on emissions scenarios with increasing projected and fixed present-day greenhouse gas and aerosol concentrations, we find that prescribed forcings from increases in anthropogenic sulfate and carbonaceous aerosols are detectable and are spatially confined to lower latitudes. Also, changes in the intertropical convergence zone and poleward shifts in the subsidence zones and the storm tracks are all detectable along with large changes in snow cover and sea ice fraction. These findings suggest that the proposed NASA Climate Absolute Radiance and Refractivity Observatory (CLARREO) mission to measure shortwave reflectance spectra may help elucidate climate forcings, responses, and feedbacks.

  16. Design and development of Building energy simulation Software for prefabricated cabin type of industrial building (PCES)

    Science.gov (United States)

    Zhang, Jun; Li, Ri Yi

    2018-06-01

    Building energy simulation is an important supporting tool for green building design and building energy consumption assessment, At present, Building energy simulation software can't meet the needs of energy consumption analysis and cabinet level micro environment control design of prefabricated building. thermal physical model of prefabricated building is proposed in this paper, based on the physical model, the energy consumption calculation software of prefabricated cabin building(PCES) is developed. we can achieve building parameter setting, energy consumption simulation and building thermal process and energy consumption analysis by PCES.

  17. Radial basis function (RBF) neural network control for mechanical systems design, analysis and Matlab simulation

    CERN Document Server

    Liu, Jinkun

    2013-01-01

    Radial Basis Function (RBF) Neural Network Control for Mechanical Systems is motivated by the need for systematic design approaches to stable adaptive control system design using neural network approximation-based techniques. The main objectives of the book are to introduce the concrete design methods and MATLAB simulation of stable adaptive RBF neural control strategies. In this book, a broad range of implementable neural network control design methods for mechanical systems are presented, such as robot manipulators, inverted pendulums, single link flexible joint robots, motors, etc. Advanced neural network controller design methods and their stability analysis are explored. The book provides readers with the fundamentals of neural network control system design.   This book is intended for the researchers in the fields of neural adaptive control, mechanical systems, Matlab simulation, engineering design, robotics and automation. Jinkun Liu is a professor at Beijing University of Aeronautics and Astronauti...

  18. Out-of-order parallel discrete event simulation for electronic system-level design

    CERN Document Server

    Chen, Weiwei

    2014-01-01

    This book offers readers a set of new approaches and tools a set of tools and techniques for facing challenges in parallelization with design of embedded systems.? It provides an advanced parallel simulation infrastructure for efficient and effective system-level model validation and development so as to build better products in less time.? Since parallel discrete event simulation (PDES) has the potential to exploit the underlying parallel computational capability in today's multi-core simulation hosts, the author begins by reviewing the parallelization of discrete event simulation, identifyin

  19. Design of the HELICS High-Performance Transmission-Distribution-Communication-Market Co-Simulation Framework

    Energy Technology Data Exchange (ETDEWEB)

    Palmintier, Bryan S [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Krishnamurthy, Dheepak [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Top, Philip [Lawrence Livermore National Laboratories; Smith, Steve [Lawrence Livermore National Laboratories; Daily, Jeff [Pacific Northwest National Laboratory; Fuller, Jason [Pacific Northwest National Laboratory

    2017-10-12

    This paper describes the design rationale for a new cyber-physical-energy co-simulation framework for electric power systems. This new framework will support very large-scale (100,000+ federates) co-simulations with off-the-shelf power-systems, communication, and end-use models. Other key features include cross-platform operating system support, integration of both event-driven (e.g. packetized communication) and time-series (e.g. power flow) simulation, and the ability to co-iterate among federates to ensure model convergence at each time step. After describing requirements, we begin by evaluating existing co-simulation frameworks, including HLA and FMI, and conclude that none provide the required features. Then we describe the design for the new layered co-simulation architecture.

  20. Nuclear power plant human computer interface design incorporating console simulation, operations personnel, and formal evaluation techniques

    International Nuclear Information System (INIS)

    Chavez, C.; Edwards, R.M.; Goldberg, J.H.

    1993-01-01

    New CRT-based information displays which enhance the human machine interface are playing a very important role and are being increasingly used in control rooms since they present a higher degree of flexibility compared to conventional hardwired instrumentation. To prototype a new console configuration and information display system at the Experimental Breeder Reactor II (EBR-II), an iterative process of console simulation and evaluation involving operations personnel is being pursued. Entire panels including selector switches and information displays are simulated and driven by plant dynamical simulations with realistic responses that reproduce the actual cognitive and physical environment. Careful analysis and formal evaluation of operator interaction while using the simulated console will be conducted to determine underlying principles for effective control console design for this particular group of operation personnel. Additional iterations of design, simulation, and evaluation will then be conducted as necessary

  1. Design and Simulation of a T-Type Lymphocyte Cells Filter on a Microfluidic System

    Directory of Open Access Journals (Sweden)

    Daniel A. Quiroga T.

    2016-01-01

    Full Text Available This work consisted in designing and validating, by experimental computational simulation, a T-Lymphocites filtering system based on microfluidics for hiv virus detection. Material and methods: It was used AutoDesk® Inventor simulation tool was used with which the microflui­dic system design was performed. The filter system was tested by a computer simulation in the AutoDesk® Simulation cfd (computational fluid dynamics software, simulation tool in which different particles with different diameters (5 μm, 10 μm, 15 μm flow through the system to test. Results and conclusions: Results showed that this system allowed to pass the expected particles, however, it also was observed that it allows bigger particles than desired, for this reason it is neces­sary to keep on working on system perfectioning. Filtering system efficiency was of a 33.33 %.

  2. Gate design in injection molding of microfluidic components using process simulations

    DEFF Research Database (Denmark)

    Marhöfer, David Maximilian; Tosello, Guido; Islam, Aminul

    2015-01-01

    to moulding process window, polymer flow, and part quality. This finally led to an optimization of the design and the realization as actual steel mold. Additionally, the simulation results were critically discussed and possible improvements and limitations of the gained results and the deployed software......Process simulations are an effective design and optimization tool in conventional as well as micro injection molding (μIM). They can be applied to optimize and assist the design of the micro part, the mold, the micro cavity and the μIM process. Available simulation software is however developed...... for macroscopic plastic parts. By using the correct implementation and careful modelling though, it can also be applied to micro parts. In the present work, process simulations were applied to a microfluidic distributor and a microfluidic mixer of which features were in the 100 μm dimensional range. The meshing...

  3. Interim Service ISDN Satellite (ISIS) simulator development for advanced satellite designs and experiments

    Science.gov (United States)

    Pepin, Gerard R.

    1992-01-01

    The simulation development associated with the network models of both the Interim Service Integrated Services Digital Network (ISDN) Satellite (ISIS) and the Full Service ISDN Satellite (FSIS) architectures is documented. The ISIS Network Model design represents satellite systems like the Advanced Communications Technology Satellite (ACTS) orbiting switch. The FSIS architecture, the ultimate aim of this element of the Satellite Communications Applications Research (SCAR) Program, moves all control and switching functions on-board the next generation ISDN communications satellite. The technical and operational parameters for the advanced ISDN communications satellite design will be obtained from the simulation of ISIS and FSIS engineering software models for their major subsystems. Discrete event simulation experiments will be performed with these models using various traffic scenarios, design parameters, and operational procedures. The data from these simulations will be used to determine the engineering parameters for the advanced ISDN communications satellite.

  4. DSC: software tool for simulation-based design of control strategies applied to wastewater treatment plants.

    Science.gov (United States)

    Ruano, M V; Ribes, J; Seco, A; Ferrer, J

    2011-01-01

    This paper presents a computer tool called DSC (Simulation based Controllers Design) that enables an easy design of control systems and strategies applied to wastewater treatment plants. Although the control systems are developed and evaluated by simulation, this tool aims to facilitate the direct implementation of the designed control system to the PC of the full-scale WWTP (wastewater treatment plants). The designed control system can be programmed in a dedicated control application and can be connected to either the simulation software or the SCADA of the plant. To this end, the developed DSC incorporates an OPC server (OLE for process control) which facilitates an open-standard communication protocol for different industrial process applications. The potential capabilities of the DSC tool are illustrated through the example of a full-scale application. An aeration control system applied to a nutrient removing WWTP was designed, tuned and evaluated with the DSC tool before its implementation in the full scale plant. The control parameters obtained by simulation were suitable for the full scale plant with only few modifications to improve the control performance. With the DSC tool, the control systems performance can be easily evaluated by simulation. Once developed and tuned by simulation, the control systems can be directly applied to the full-scale WWTP.

  5. Computational Design and Simulation of Bending-Active Auxetic Structures

    Directory of Open Access Journals (Sweden)

    Roberto Naboni

    2016-11-01

    Full Text Available O artigo investiga a potencial aplicação de estruturas auxéticas na arquitetura através da combinação de métodos de desenho computacional e Manufatura Aditiva (MA. Essa classe de materiais apresenta comportamento interessante relacionado à característica pouco comum de possuir coeficiente de Poisson negativo, ou seja, ao contrário de outros materiais, quando tracionados expandem-se transversalmente e quando comprimidos contraem-se transversalmente. Explora-se um novo campo de pesquisa e design onde diferentes arranjos de auxéticos são estudados com intuito de informar um processo de form-finding de estruturas de cascas nervuradas sinclásticas de flexão-ativa (bending-active. Metodologias computacionais foram empregadas para visualizar o comportamento dinâmico destas estruturas utilizando Sistemas Massa-Mola. Princípios para o projeto e fabricação de cascas nervuradas auxéticas são investigados através de fabricação aditiva em diferentes escalas. Este processo é empregado para produzir modelos em escala úteis para a compreensão do comportamento auxético, assim como visionar a fabricação de mega-estruturas auxéticas com organização micro estrutural ótima. A resistência à flexão destes sistemas é cautelosamente controlada pelo uso de arranjos de enchimento variável informados por análise estrutural. Finalmente, é proposto um protótipo de casca nervurada em tamanho real como estudo de caso, em conjunto com um novo conceito para sua construção em fabricação aditiva in situ.

  6. 3D Integration of MEMS and IC: Design, technology and simulations

    OpenAIRE

    Schjølberg-Henriksen, Kari

    2009-01-01

    * 3D integration: Opportunities and trends* e-CUBES: Tire pressure monitoring system (TPMS)* Package design including thermo-mechanical modeling* Technology development* Sensor packaging concept* Gold stud bump bonding* Device characterization and testing* Summary and outlook 3D Integration of MEMS and IC: Design, technology and simulations

  7. Designing simulation experiments with controllable and uncontrollable factors for applications in healthcare

    DEFF Research Database (Denmark)

    Dehlendorff, Christian; Kulahci, Murat; Andersen, Klaus Kaae

    2011-01-01

    We propose a new methodology for designing computer experiments that was inspired by the split-plot designs that are often used in physical experimentation.The methodology has been developed for a simulation model of a surgical unit in a Danish hospital.We classify the factors as controllable and...

  8. Sensitivity analysis by experimental design and metamodelling : case study on simulation in national animal disease control

    NARCIS (Netherlands)

    Vonk Noordegraaf, A.; Nielen, M.; Kleijnen, J.P.C.

    2003-01-01

    Simulation is a frequently applied tool in the discipline of animal health economics. Application of sensitivity analysis, however, is often limited to changing only one factor at a time (OAT designs). In this study, the statistical techniques of Design of Experiments (DOE) and regression

  9. Multi-Disciplinary Design Support using Hardware-in-the-Loop Simulation

    NARCIS (Netherlands)

    Visser, P.M.; Groothuis, M.A.; Broenink, Johannes F.

    2004-01-01

    This paper describes a method using Hardware-in-the-Loop Simulation as a means for multidisciplinary design support. The method presented here, aims at supporting the design of heterogeneous embedded control systems. The method considers the implementation process as a stepwise refinement from

  10. A Framework for the Design of Computer-Assisted Simulation Training for Complex Police Situations

    Science.gov (United States)

    Söderström, Tor; Åström, Jan; Anderson, Greg; Bowles, Ron

    2014-01-01

    Purpose: The purpose of this paper is to report progress concerning the design of a computer-assisted simulation training (CAST) platform for developing decision-making skills in police students. The overarching aim is to outline a theoretical framework for the design of CAST to facilitate police students' development of search techniques in…

  11. A Simulation-Based LED Design Project in Photonics Instruction Based on Industry-University Collaboration

    Science.gov (United States)

    Chang, S. -H.; Chen, M. -L.; Kuo, Y. -K.; Shen, Y. -C.

    2011-01-01

    In response to the growing industrial demand for light-emitting diode (LED) design professionals, based on industry-university collaboration in Taiwan, this paper develops a novel instructional approach: a simulation-based learning course with peer assessment to develop students' professional skills in LED design as required by industry as well as…

  12. Design of full scale wave simulator for testing Power Take Off systems for wave energy converters

    DEFF Research Database (Denmark)

    Pedersen, H. C.; Hansen, R. H.; Hansen, Anders Hedegaard

    2016-01-01

    is therefore on the design and commissioning of a full scale wave simulator for testing PTO-systems for point absorbers. The challenge is to be able to design a system, which mimics the behavior of a wave when interacting with a given PTO-system – especially when considering discrete type PTO...

  13. The Interior Design Simulator. Courseware Evaluation for Vocational and Technical Education.

    Science.gov (United States)

    Worts, Nancy; And Others

    This courseware evaluation rates the Interior Design Simulator program developed by Orange Juice Software Systems. (This program--not contained in this document--allows the user to design a room of any shape with maximum dimensions of 14 x 26 feet.) Part A describes the program in terms of subject area (furniture arrangement) and hardware…

  14. Building performance simulation in the early design stage: An introduction to integrated dynamic models

    DEFF Research Database (Denmark)

    Negendahl, Kristoffer

    2015-01-01

    , a visual programming language and a BPS to provide better support for the designer during the early stages of design as opposed to alternatives such as the current implementation of IFC or gbXML or the unaccompanied use of simulation packages. (C) 2015 Elsevier B.V. All rights reserved....

  15. Rapid prototyping in order to improve building performance simulation for detailed design support

    NARCIS (Netherlands)

    Hopfe, C.J.; Hensen, J.L.M.; Stankov, P.

    2006-01-01

    Building performance simulation (BPS) is a powerful tool to support building and system designers in emulating how orientation, building type, HVAC system etc. interacts the overall building performance. Currently BPS is used only for code compliance in the detailed design, neither to make informed

  16. A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1.

    Science.gov (United States)

    Vercoulen, Yvonne; Kondo, Yasushi; Iwig, Jeffrey S; Janssen, Axel B; White, Katharine A; Amini, Mojtaba; Barber, Diane L; Kuriyan, John; Roose, Jeroen P

    2017-09-27

    RasGRPs are guanine nucleotide exchange factors that are specific for Ras or Rap, and are important regulators of cellular signaling. Aberrant expression or mutation of RasGRPs results in disease. An analysis of RasGRP1 SNP variants led to the conclusion that the charge of His 212 in RasGRP1 alters signaling activity and plasma membrane recruitment, indicating that His 212 is a pH sensor that alters the balance between the inactive and active forms of RasGRP1. To understand the structural basis for this effect we compared the structure of autoinhibited RasGRP1, determined previously, to those of active RasGRP4:H-Ras and RasGRP2:Rap1b complexes. The transition from the autoinhibited to the active form of RasGRP1 involves the rearrangement of an inter-domain linker that displaces inhibitory inter-domain interactions. His 212 is located at the fulcrum of these conformational changes, and structural features in its vicinity are consistent with its function as a pH-dependent switch.

  17. MEMS 3-DoF gyroscope design, modeling and simulation through equivalent circuit lumped parameter model

    International Nuclear Information System (INIS)

    Mian, Muhammad Umer; Khir, M. H. Md.; Tang, T. B.; Dennis, John Ojur; Riaz, Kashif; Iqbal, Abid; Bazaz, Shafaat A.

    2015-01-01

    Pre-fabrication, behavioural and performance analysis with computer aided design (CAD) tools is a common and fabrication cost effective practice. In light of this we present a simulation methodology for a dual-mass oscillator based 3 Degree of Freedom (3-DoF) MEMS gyroscope. 3-DoF Gyroscope is modeled through lumped parameter models using equivalent circuit elements. These equivalent circuits consist of elementary components which are counterpart of their respective mechanical components, used to design and fabricate 3-DoF MEMS gyroscope. Complete designing of equivalent circuit model, mathematical modeling and simulation are being presented in this paper. Behaviors of the equivalent lumped models derived for the proposed device design are simulated in MEMSPRO T-SPICE software. Simulations are carried out with the design specifications following design rules of the MetalMUMPS fabrication process. Drive mass resonant frequencies simulated by this technique are 1.59 kHz and 2.05 kHz respectively, which are close to the resonant frequencies found by the analytical formulation of the gyroscope. The lumped equivalent circuit modeling technique proved to be a time efficient modeling technique for the analysis of complex MEMS devices like 3-DoF gyroscopes. The technique proves to be an alternative approach to the complex and time consuming couple field analysis Finite Element Analysis (FEA) previously used

  18. MEMS 3-DoF gyroscope design, modeling and simulation through equivalent circuit lumped parameter model

    Energy Technology Data Exchange (ETDEWEB)

    Mian, Muhammad Umer, E-mail: umermian@gmail.com; Khir, M. H. Md.; Tang, T. B. [Department of Electrical and Electronic Engineering, Universiti Teknologi PETRONAS, Tronoh, Perak (Malaysia); Dennis, John Ojur [Department of Fundamental & Applied Sciences, Universiti Teknologi PETRONAS, Tronoh, Perak (Malaysia); Riaz, Kashif; Iqbal, Abid [Faculty of Electronics Engineering, GIK Institute of Engineering Sciences and Technology, Topi, Khyber Pakhtunkhaw (Pakistan); Bazaz, Shafaat A. [Department of Computer Science, Center for Advance Studies in Engineering, Islamabad (Pakistan)

    2015-07-22

    Pre-fabrication, behavioural and performance analysis with computer aided design (CAD) tools is a common and fabrication cost effective practice. In light of this we present a simulation methodology for a dual-mass oscillator based 3 Degree of Freedom (3-DoF) MEMS gyroscope. 3-DoF Gyroscope is modeled through lumped parameter models using equivalent circuit elements. These equivalent circuits consist of elementary components which are counterpart of their respective mechanical components, used to design and fabricate 3-DoF MEMS gyroscope. Complete designing of equivalent circuit model, mathematical modeling and simulation are being presented in this paper. Behaviors of the equivalent lumped models derived for the proposed device design are simulated in MEMSPRO T-SPICE software. Simulations are carried out with the design specifications following design rules of the MetalMUMPS fabrication process. Drive mass resonant frequencies simulated by this technique are 1.59 kHz and 2.05 kHz respectively, which are close to the resonant frequencies found by the analytical formulation of the gyroscope. The lumped equivalent circuit modeling technique proved to be a time efficient modeling technique for the analysis of complex MEMS devices like 3-DoF gyroscopes. The technique proves to be an alternative approach to the complex and time consuming couple field analysis Finite Element Analysis (FEA) previously used.

  19. Analysis and design of lean direct injection fuel nozzles by eddy resolved turbulence simulation

    Science.gov (United States)

    Ryon, Jason Allen

    Combustion systems in gas turbine engines are subjected to particular scrutiny in regards to the emissions which they produce. Of special interest are the emissions of Oxides of Nitrogen (NOx), which have a direct impact on air quality as well as health aspects. There is a need in the industry for elegant designs for these combustion systems which reduce the formation of NOx. The present study includes an in depth analysis of a state-of-the art prefilming airblast injector which is designed for achieving low NOx. The design has been studied through the use of turbulence resolving simulation to differentiate what is important for the design of this system. The OpenFOAM CFD software, with a Delayed Detached Eddy Simulation (DDES) model recently developed at Iowa State University, is shown to provide a suitable design tool which has been used to accurately predict a variety of parameters important to this combustion system. Of particular interest are the mixing characteristics of the atomizer, which have been studied through a series of CFD simulations including single-phase, multi-species, and multi-phase simulations. Turbulence simulations are validated by comparison to United Technologies Aerospace Systems (UTAS) data with air only. It is shown how DDES is able to capture the downstream mixing of air streams. Finally, a novel atomizer has been designed with these methods which is intended to promote thorough mixing. The CFD mixing characteristics are described and compared to the existing injector.

  20. Development of nuclear power plant simulators for Soviet-designed nuclear reactors

    International Nuclear Information System (INIS)

    Kohut, P.; Tutu, N.K.; Cleary, E.J.; Erickson, K.G.; Yoder, J.; Kroshilin, A.

    2001-01-01

    The US Department of Energy (US DOE), under the US government's International Nuclear Safety Program (INSP), is implementing a program of developing and providing simulators for many of the Russian and Ukrainian Nuclear Power Plants (NPPs). Pacific Northwest National Laboratory (PNNL) and Brookhaven National Laboratory (BNL) manage and provide technical oversight of the various INSP simulator projects for DOE. The program also includes a simulator technology transfer process to simulator design organizations in Russia and Ukraine. Training programs, installation of new simulators, and enhancements in existing simulators, are viewed as providing a relatively fast and cost-effective technology transfer that will result in measurable improvement in the safety culture and operation of NPPs. A review of this program, its present status, and its accomplishments are provided in this paper

  1. Optimal design and uncertainty quantification in blood flow simulations for congenital heart disease

    Science.gov (United States)

    Marsden, Alison

    2009-11-01

    Recent work has demonstrated substantial progress in capabilities for patient-specific cardiovascular flow simulations. Recent advances include increasingly complex geometries, physiological flow conditions, and fluid structure interaction. However inputs to these simulations, including medical image data, catheter-derived pressures and material properties, can have significant uncertainties associated with them. For simulations to predict clinically useful and reliable output information, it is necessary to quantify the effects of input uncertainties on outputs of interest. In addition, blood flow simulation tools can now be efficiently coupled to shape optimization algorithms for surgery design applications, and these tools should incorporate uncertainty information. We present a unified framework to systematically and efficient account for uncertainties in simulations using adaptive stochastic collocation. In addition, we present a framework for derivative-free optimization of cardiovascular geometries, and layer these tools to perform optimization under uncertainty. These methods are demonstrated using simulations and surgery optimization to improve hemodynamics in pediatric cardiology applications.

  2. Modeling, simulation, and concept design for hybrid-electric medium-size military trucks

    Science.gov (United States)

    Rizzoni, Giorgio; Josephson, John R.; Soliman, Ahmed; Hubert, Christopher; Cantemir, Codrin-Gruie; Dembski, Nicholas; Pisu, Pierluigi; Mikesell, David; Serrao, Lorenzo; Russell, James; Carroll, Mark

    2005-05-01

    A large scale design space exploration can provide valuable insight into vehicle design tradeoffs being considered for the U.S. Army"s FMTV (Family of Medium Tactical Vehicles). Through a grant from TACOM (Tank-automotive and Armaments Command), researchers have generated detailed road, surface, and grade conditions representative of the performance criteria of this medium-sized truck and constructed a virtual powertrain simulator for both conventional and hybrid variants. The simulator incorporates the latest technology among vehicle design options, including scalable ultracapacitor and NiMH battery packs as well as a variety of generator and traction motor configurations. An energy management control strategy has also been developed to provide efficiency and performance. A design space exploration for the family of vehicles involves running a large number of simulations with systematically varied vehicle design parameters, where each variant is paced through several different mission profiles and multiple attributes of performance are measured. The resulting designs are filtered to remove dominated designs, exposing the multi-criterial surface of optimality (Pareto optimal designs), and revealing the design tradeoffs as they impact vehicle performance and economy. The results are not yet definitive because ride and drivability measures were not included, and work is not finished on fine-tuning the modeled dynamics of some powertrain components. However, the work so far completed demonstrates the effectiveness of the approach to design space exploration, and the results to date suggest the powertrain configuration best suited to the FMTV mission.

  3. Robotic Irradiated Sample Handling Concept Design in Reactor TRIGA PUSPATI using Simulation Software

    International Nuclear Information System (INIS)

    Mohd Khairulezwan Abdul Manan; Mohd Sabri Minhat; Ridzuan Abdul Mutalib; Zareen Khan Abdul Jalil Khan; Nurfarhana Ayuni Joha

    2015-01-01

    This paper introduces the concept design of an Robotic Irradiated Sample Handling Machine using graphical software application, designed as a general, flexible and open platform to work on robotics. Webots has proven to be a useful tool in many fields of robotics, such as manipulator programming, mobile robots control (wheeled, sub-aquatic and walking robots), distance computation, sensor simulation, collision detection, motion planning and so on. Webots is used as the common interface for all the applications. Some practical cases and application for this concept design are illustrated on the paper to present the possibilities of this simulation software. (author)

  4. Method for simulating predictive control of building systems operation in the early stages of building design

    DEFF Research Database (Denmark)

    Petersen, Steffen; Svendsen, Svend

    2011-01-01

    A method for simulating predictive control of building systems operation in the early stages of building design is presented. The method uses building simulation based on weather forecasts to predict whether there is a future heating or cooling requirement. This information enables the thermal...... control systems of the building to respond proactively to keep the operational temperature within the thermal comfort range with the minimum use of energy. The method is implemented in an existing building simulation tool designed to inform decisions in the early stages of building design through...... parametric analysis. This enables building designers to predict the performance of the method and include it as a part of the solution space. The method furthermore facilitates the task of configuring appropriate building systems control schemes in the tool, and it eliminates time consuming manual...

  5. Acoustic Analysis and Design of the E-STA MSA Simulator

    Science.gov (United States)

    Bittinger, Samantha A.

    2016-01-01

    The Orion European Service Module Structural Test Article (E-STA) Acoustic Test was completed in May 2016 to verify that the European Service Module (ESM) can withstand qualification acoustic environments. The test article required an aft closeout to simulate the Multi-Purpose Crew Vehicle (MPCV) Stage Adapter (MSA) cavity, however, the flight MSA design was too cost-prohibitive to build. NASA Glenn Research Center (GRC) had 6 months to design an MSA Simulator that could recreate the qualification prediction MSA cavity sound pressure level to within a reasonable tolerance. This paper summarizes the design and analysis process to arrive at a design for the MSA Simulator, and then compares its performance to the final prediction models created prior to test.

  6. A high-compression electron gun for C6+ production: concept, simulations and mechanical design

    Science.gov (United States)

    Mertzig, Robert; Breitenfeldt, M.; Mathot, S.; Pitters, J.; Shornikov, A.; Wenander, F.

    2017-07-01

    In this paper we report on simulations and the mechanical design of a high-compression electron gun for an Electron Beam Ion Source (EBIS) dedicated for production of high intensity and high repetition rate pulses of bare carbon ions for injection into linac-based hadron therapy facilities. The gun is presently under construction at CERN to be retrofitted into the TwinEBIS test bench for experimental studies. We describe the design constraints, show results of numeric simulations and report on the mechanical design featuring several novel ideas. The reported design makes use of combined-function units with reduced number of mechanical joints that were carefully controlled and tuned during the manufacturing phase. The simulations addressed a wide range of topics including the influence of thermal effects, focusing optics, symmetry-breaking misalignments and injection into a full 5 T field.

  7. Numerical Simulation and Mechanical Design for TPS Electron Beam Position Monitors

    Science.gov (United States)

    Hsueh, H. P.; Kuan, C. K.; Ueng, T. S.; Hsiung, G. Y.; Chen, J. R.

    2007-01-01

    Comprehensive study on the mechanical design and numerical simulation for the high resolution electron beam position monitors are key steps to build the newly proposed 3rd generation synchrotron radiation research facility, Taiwan Photon Source (TPS). With more advanced electromagnetic simulation tool like MAFIA tailored specifically for particle accelerator, the design for the high resolution electron beam position monitors can be tested in such environment before they are experimentally tested. The design goal of our high resolution electron beam position monitors is to get the best resolution through sensitivity and signal optimization. The definitions and differences between resolution and sensitivity of electron beam position monitors will be explained. The design consideration is also explained. Prototype deign has been carried out and the related simulations were also carried out with MAFIA. The results are presented here. Sensitivity as high as 200 in x direction has been achieved in x direction at 500 MHz.

  8. Numerical Simulation and Mechanical Design for TPS Electron Beam Position Monitors

    International Nuclear Information System (INIS)

    Hsueh, H. P.; Kuan, C. K.; Ueng, T. S.; Hsiung, G. Y.; Chen, J. R.

    2007-01-01

    Comprehensive study on the mechanical design and numerical simulation for the high resolution electron beam position monitors are key steps to build the newly proposed 3rd generation synchrotron radiation research facility, Taiwan Photon Source (TPS). With more advanced electromagnetic simulation tool like MAFIA tailored specifically for particle accelerator, the design for the high resolution electron beam position monitors can be tested in such environment before they are experimentally tested. The design goal of our high resolution electron beam position monitors is to get the best resolution through sensitivity and signal optimization. The definitions and differences between resolution and sensitivity of electron beam position monitors will be explained. The design consideration is also explained. Prototype deign has been carried out and the related simulations were also carried out with MAFIA. The results are presented here. Sensitivity as high as 200 in x direction has been achieved in x direction at 500 MHz

  9. Visual-Simulation-Based Personalized Garment Block Design Method for Physically Disabled People with Scoliosis (PDPS

    Directory of Open Access Journals (Sweden)

    Hong Yan

    2018-03-01

    Full Text Available This research presented a novel method using 3D simulation methods to design customized garments for physically disabled people with scoliosis (PDPS. The proposed method is based on the virtual human model created from 3D scanning, permitting to simulate the consumer’s morphological shape with atypical physical deformations. Next, customized 2D and 3D virtual garment prototyping tools will be used to create products through interactions. The proposed 3D garment design method is based on the concept of knowledge-based design, using the design knowledge and process already applied to normal body shapes successfully. The characters of the PDPS and the relationship between human body and garment are considered in the prototyping process. As a visualized collaborative design process, the communication between designer and consumer is ensured, permitting to adapt the finished product to disabled people afflicted with severe scoliosis.

  10. Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics

    Science.gov (United States)

    Iversen, Lars; Tu, Hsiung-Lin; Lin, Wan-Chen; Christensen, Sune M.; Abel, Steven M.; Iwig, Jeff; Wu, Hung-Jen; Gureasko, Jodi; Rhodes, Christopher; Petit, Rebecca S.; Hansen, Scott D.; Thill, Peter; Yu, Cheng-Han; Stamou, Dimitrios; Chakraborty, Arup K.; Kuriyan, John; Groves, Jay T.

    2014-01-01

    Activation of the small guanosine triphosphatase H-Ras by the exchange factor Son of Sevenless (SOS) is an important hub for signal transduction. Multiple layers of regulation, through protein and membrane interactions, govern activity of SOS. We characterized the specific activity of individual SOS molecules catalyzing nucleotide exchange in H-Ras. Single-molecule kinetic traces revealed that SOS samples a broad distribution of turnover rates through stochastic fluctuations between distinct, long-lived (more than 100 seconds), functional states. The expected allosteric activation of SOS by Ras–guanosine triphosphate (GTP) was conspicuously absent in the mean rate. However, fluctuations into highly active states were modulated by Ras-GTP. This reveals a mechanism in which functional output may be determined by the dynamical spectrum of rates sampled by a small number of enzymes, rather than the ensemble average. PMID:24994643

  11. The Protective Arm of the Renin Angiotensin System (RAS)

    DEFF Research Database (Denmark)

    understanding of the protective side of the Renin Angiotensin System (RAS) involving angiotensin AT2 receptor, ACE2, and Ang(1-7)/Mas receptor Combines the knowledge of editors who pioneered research on the protective renin angiotensin system including; Dr. Thomas Unger, one of the founders of AT2 receptor......The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin-angiotensin system (RAS), providing readers with early insight into a complex system which...... will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1-7) peptide with its receptor...

  12. Influence of feed ingredients on water quality parameters in RAS

    DEFF Research Database (Denmark)

    Pedersen, Per Bovbjerg; Pedersen, Lars-Flemming; Suhr, Karin Isabel

    2011-01-01

    Although feed by far is providing the major input to RAS, relatively little is published about the correlation between feed composition and the resulting water quality in such systems. In a set-up with 6 identical RAS, each consisting of a fish tank (0.5 m3), a swirl separator, a submerged...... had impact on water quality in the systems as well as on matter removed by the swirl separators. In the RAS water, phosphorous (Ptot and Pdiss) concentrations were reduced by guar gum. Organic matter content (CODdiss) in the water was also reduced. Corresponding to this, more dry matter, more COD...... to the systems for 49 consecutive days. Each week, 24h-water samples (1 sample/hour) were collected from each system. The sludge collected in the swirl separator that day was also collected. Water and sludge were subsequently analysed for nitrogen, phosphorous and organic matter content. Inclusion of guar gum...

  13. PREFACE: International Conference on Quantum Simulators and Design, Hiroshima, Japan, 3 6 December 2006

    Science.gov (United States)

    Akai, Hisazumi; Oguchi, Tamio

    2007-09-01

    This special issue of Journal of Physics: Condensed Matter comprises selected papers from the 1st International Conference on Quantum Simulators and Design (QSD2006) held in Hiroshima, Japan, 3-6 December 2006. This conference was organized under the auspices of the Development of New Quantum Simulators and Quantum Design Grant-in-Aid for Scientific Research on Priority Areas, Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT), and Hiroshima University Quantum design is a computational approach to the development of new materials with specified properties and functionalities. The basic ingredient is the use of quantum simulations to design a material that meets a given specification of properties and functionalities. For this to be successful, the quantum simulation should be highly reliable and be applicable to systems of realistic size. A central interest is, therefore, the development of new methods of quantum simulation and quantum design. This includes methods beyond the local density approximation of density functional theory (LDA), order-N methods, methods dealing with excitations and reactions, and so on, as well as the application of these methods to the design of new materials and devices. The field of quantum design has developed rapidly in the past few years and this conference provides an international forum for experimental and theoretical researchers to exchange ideas. A total of 183 delegates from 8 countries participated in the conference. There were 18 invited talks, 16 oral presentations and 100 posters. There were many new ideas and we foresee dramatic progress in the coming years. The 2nd International Conference on Quantum Simulators and Design will be held in Tokyo, Japan, 31 May-3 June 2008.

  14. GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site*

    Science.gov (United States)

    Lu, Shaoyong; Banerjee, Avik; Jang, Hyunbum; Zhang, Jian; Gaponenko, Vadim; Nussinov, Ruth

    2015-01-01

    K-Ras4B, a frequently mutated oncogene in cancer, plays an essential role in cell growth, differentiation, and survival. Its C-terminal membrane-associated hypervariable region (HVR) is required for full biological activity. In the active GTP-bound state, the HVR interacts with acidic plasma membrane (PM) headgroups, whereas the farnesyl anchors in the membrane; in the inactive GDP-bound state, the HVR may interact with both the PM and the catalytic domain at the effector binding region, obstructing signaling and nucleotide exchange. Here, using molecular dynamics simulations and NMR, we aim to figure out the effects of nucleotides (GTP and GDP) and frequent (G12C, G12D, G12V, G13D, and Q61H) and infrequent (E37K and R164Q) oncogenic mutations on full-length K-Ras4B. The mutations are away from or directly at the HVR switch I/effector binding site. Our results suggest that full-length wild-type GDP-bound K-Ras4B (K-Ras4BWT-GDP) is in an intrinsically autoinhibited state via tight HVR-catalytic domain interactions. The looser association in K-Ras4BWT-GTP may release the HVR. Some of the oncogenic mutations weaken the HVR-catalytic domain association in the K-Ras4B-GDP/-GTP bound states, which may facilitate the HVR disassociation in a nucleotide-independent manner, thereby up-regulating oncogenic Ras signaling. Thus, our results suggest that mutations can exert their effects in more than one way, abolishing GTP hydrolysis and facilitating effector binding. PMID:26453300

  15. GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site.

    Science.gov (United States)

    Lu, Shaoyong; Banerjee, Avik; Jang, Hyunbum; Zhang, Jian; Gaponenko, Vadim; Nussinov, Ruth

    2015-11-27

    K-Ras4B, a frequently mutated oncogene in cancer, plays an essential role in cell growth, differentiation, and survival. Its C-terminal membrane-associated hypervariable region (HVR) is required for full biological activity. In the active GTP-bound state, the HVR interacts with acidic plasma membrane (PM) headgroups, whereas the farnesyl anchors in the membrane; in the inactive GDP-bound state, the HVR may interact with both the PM and the catalytic domain at the effector binding region, obstructing signaling and nucleotide exchange. Here, using molecular dynamics simulations and NMR, we aim to figure out the effects of nucleotides (GTP and GDP) and frequent (G12C, G12D, G12V, G13D, and Q61H) and infrequent (E37K and R164Q) oncogenic mutations on full-length K-Ras4B. The mutations are away from or directly at the HVR switch I/effector binding site. Our results suggest that full-length wild-type GDP-bound K-Ras4B (K-Ras4B(WT)-GDP) is in an intrinsically autoinhibited state via tight HVR-catalytic domain interactions. The looser association in K-Ras4B(WT)-GTP may release the HVR. Some of the oncogenic mutations weaken the HVR-catalytic domain association in the K-Ras4B-GDP/-GTP bound states, which may facilitate the HVR disassociation in a nucleotide-independent manner, thereby up-regulating oncogenic Ras signaling. Thus, our results suggest that mutations can exert their effects in more than one way, abolishing GTP hydrolysis and facilitating effector binding. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  16. Simulation based evaluation of the designs of the Advanced Gamma-ray Imageing System (AGIS)

    Science.gov (United States)

    Bugaev, Slava; Buckley, James; Digel, Seth; Funk, Stephen; Konopelko, Alex; Krawczynski, Henric; Lebohec, Steohan; Maier, Gernot; Vassiliev, Vladimir

    2009-05-01

    The AGIS project under design study, is a large array of imaging atmospheric Cherenkov telescopes for gamma-rays astronomy between 40GeV and 100 TeV. In this paper we present the ongoing simulation effort to model the considered design approaches as a function of the main parameters such as array geometry, telescope optics and camera design in such a way the gamma ray observation capabilities can be optimized against the overall project cost.

  17. A study on three dimensional layout design by the simulated annealing method

    International Nuclear Information System (INIS)

    Jang, Seung Ho

    2008-01-01

    Modern engineered products are becoming increasingly complicated and most consumers prefer compact designs. Layout design plays an important role in many engineered products. The objective of this study is to suggest a method to apply the simulated annealing method to the arbitrarily shaped three-dimensional component layout design problem. The suggested method not only optimizes the packing density but also satisfies constraint conditions among the components. The algorithm and its implementation as suggested in this paper are extendable to other research objectives

  18. Integrated layout based Monte-Carlo simulation for design arc optimization

    Science.gov (United States)

    Shao, Dongbing; Clevenger, Larry; Zhuang, Lei; Liebmann, Lars; Wong, Robert; Culp, James

    2016-03-01

    Design rules are created considering a wafer fail mechanism with the relevant design levels under various design cases, and the values are set to cover the worst scenario. Because of the simplification and generalization, design rule hinders, rather than helps, dense device scaling. As an example, SRAM designs always need extensive ground rule waivers. Furthermore, dense design also often involves "design arc", a collection of design rules, the sum of which equals critical pitch defined by technology. In design arc, a single rule change can lead to chain reaction of other rule violations. In this talk we present a methodology using Layout Based Monte-Carlo Simulation (LBMCS) with integrated multiple ground rule checks. We apply this methodology on SRAM word line contact, and the result is a layout that has balanced wafer fail risks based on Process Assumptions (PAs). This work was performed at the IBM Microelectronics Div, Semiconductor Research and Development Center, Hopewell Junction, NY 12533

  19. FEM design and simulation of a short, 10 MV, S-band Linac with Monte Carlo dose simulations

    International Nuclear Information System (INIS)

    Baillie, Devin; Aubin, J. St.; Steciw, S.; Fallone, B. G.

    2015-01-01

    Purpose: Current commercial 10 MV Linac waveguides are 1.5 m. The authors’ current 6 MV linear accelerator–magnetic resonance imager (Linac–MR) system fits in typical radiotherapy vaults. To allow 10 MV treatments with the Linac–MR and still fit within typical vaults, the authors design a 10 MV Linac with an accelerator waveguide of the same length (27.5 cm) as current 6 MV Linacs. Methods: The first design stage is to design a cavity such that a specific experimental measurement for breakdown is applicable to the cavity. This is accomplished through the use of finite element method (FEM) simulations to match published shunt impedance, Q factor, and ratio of peak to mean-axial electric field strength from an electric breakdown study. A full waveguide is then designed and tuned in FEM simulations based on this cavity design. Electron trajectories are computed through the resulting radio frequency fields, and the waveguide geometry is modified by shifting the first coupling cavity in order to optimize the electron beam properties until the energy spread and mean energy closely match values published for an emulated 10 MV Linac. Finally, Monte Carlo dose simulations are used to compare the resulting photon beam depth dose profile and penumbra with that produced by the emulated 10 MV Linac. Results: The shunt impedance, Q factor, and ratio of peak to mean-axial electric field strength are all matched to within 0.1%. A first coupling cavity shift of 1.45 mm produces an energy spectrum width of 0.347 MeV, very close to the published value for the emulated 10 MV of 0.315 MeV, and a mean energy of 10.53 MeV, nearly identical to the published 10.5 MeV for the emulated 10 MV Linac. The depth dose profile produced by their new Linac is within 1% of that produced by the emulated 10 MV spectrum for all depths greater than 1.5 cm. The penumbra produced is 11% narrower, as measured from 80% to 20% of the central axis dose. Conclusions: The authors have successfully

  20. Overexpression of K-p21Ras play a prominent role in lung cancer

    Science.gov (United States)

    Zhang, Peng-bo; Zhou, Xin-liang; Yang, Ju-lun

    2018-06-01

    The proto-oncogene ras product, p21Ras, has been found overexpression in many human tumors. However, the subtypes of overexpressed p21Ras still remain unclear. The purpose of this study was to investigate overexpressed isoforms of p21Ras and their roles in the progress of lung cancer. Method: The expression of total p21Ras in normal lung tissues and lung cancers was determined by immunohistochemically staining with monoclonal antibody (Mab) KGHR-1 which could recognize and broad spectrum reaction with the (K/H/N) ras protein. Then, the isoforms of p21Ras was examined by specific Mab for each p21Ras subtypes. Results: Low expression of total p21Ras was found in 26.67% (8/30) of normal lung tissues, and 81.31% (87/107) of adenocarcinoma harbored overexpressed total p21Ras. Besides, 70.00% (35/50) of squamous cell carcinoma were detected overexpressed total p21Ras. In addition, 122 lung cancer tissues from overexpression of total p21Ras protein were selected to detect the expression of each subtype. And all the 122 lung cancer tissues were K-p21Ras overexpression. Moreover, there was a statistical significance difference between the expression level of total p21Ras and differentiation, and the same results were observed between the expression level of total p21Ras and lymph node metastasis (P0.05). Conclusions: Overexpression of K-p21Ras plays a prominent role in the progress of lung cancer and it is suggested that the p21Ras could serve as a promising treatment target in lung cancer.

  1. Ras and relatives--job sharing and networking keep an old family together.

    Science.gov (United States)

    Ehrhardt, Annette; Ehrhardt, Götz R A; Guo, Xuecui; Schrader, John W

    2002-10-01

    Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells, with roles in growth, survival, differentiation, cytokine production, chemotaxis, vesicle-trafficking, and phagocytosis. The well-known p21 Ras proteins H-Ras, N-Ras, K-Ras 4A, and K-Ras 4B are also frequently mutated in human cancer and leukemia. Besides the four p21 Ras proteins, the Ras subfamily of the Ras superfamily includes R-Ras, TC21 (R-Ras2), M-Ras (R-Ras3), Rap1A, Rap1B, Rap2A, Rap2B, RalA, and RalB. They exhibit remarkable overall amino acid identities, especially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation. In addition, there is considerable sharing of various downstream effectors through which they transmit signals and of GTPase activating proteins that downregulate their activity, resulting in overlap in their regulation and effector function. Relatively little is known about the physiological functions of individual Ras family members, although the presence of well-conserved orthologs in Caenorhabditis elegans suggests that their individual roles are both specific and vital. The structural and functional similarities have meant that commonly used research tools fail to discriminate between the different family members, and functions previously attributed to one family member may be shared with other members of the Ras family. Here we discuss similarities and differences in activation, effector usage, and functions of different members of the Ras subfamily. We also review the possibility that the differential localization of Ras proteins in different parts of the cell membrane may govern their responses to activation of cell surface receptors.

  2. Conceptual design and neutronics analyses of a fusion reactor blanket simulation facility

    International Nuclear Information System (INIS)

    Beller, D.E.; Ott, K.O.; Terry, W.K.

    1987-01-01

    A new conceptual design of a fusion reactor blanket simulation facility has been developed. This design follows the principles that have been successfully employed in the Purdue Fast Breeder Blanket Facility (FBBF), where experiments have resulted in the discovery of substantial deficiencies in neutronics predictions. With this design, discrepancies between calculation and experimental data can be nearly fully attributed to calculation methods because design deficiencies that could affect results are insignificant. The conceptual design of this FBBF analog, the Fusion Reactor Blanket Facility, is presented

  3. Epac activation sensitizes rat sensory neurons via activation of Ras

    Science.gov (United States)

    Shariati, Behzad; Thompson, Eric L.; Nicol, Grant D.; Vasko, Michael R.

    2015-01-01

    Guanine nucleotide exchange factors directly activated by cAMP (Epacs) have emerged as important signaling molecules mediating persistent hypersensitivity in animal models of inflammation, by augmenting the excitability of sensory neurons. Although Epacs activate numerous downstream signaling cascades, the intracellular signaling which mediates Epac-induced sensitization of capsaicin-sensitive sensory neurons remains unknown. Here, we demonstrate that selective activation of Epacs with 8-CPT-2′-O-Me-cAMP-AM (8CPT-AM) increases the number of action potentials (APs) generated by a ramp of depolarizing current and augments the evoked release of calcitonin gene-related peptide (CGRP) from isolated rat sensory neurons. Internal perfusion of capsaicin-sensitive sensory neurons with GDP-βS, substituted for GTP, blocks the ability of 8CPT-AM to increase AP firing, demonstrating that Epac-induced sensitization is G-protein dependent. Treatment with 8CPT-AM activates the small G-proteins Rap1 and Ras in cultures of sensory neurons. Inhibition of Rap1, by internal perfusion of a Rap1-neutralizing antibody or through a reduction in the expression of the protein using shRNA does not alter the Epac-induced enhancement of AP generation or CGRP release, despite the fact that in most other cell types, Epacs act as Rap-GEFs. In contrast, inhibition of Ras through expression of a dominant negative Ras (DN-Ras) or through internal perfusion of a Ras-neutralizing antibody blocks the increase in AP firing and attenuates the increase in the evoked release of CGRP induced by Epac activation. Thus, in this subpopulation of nociceptive sensory neurons, it is the novel interplay between Epacs and Ras, rather than the canonical Epacs and Rap1 pathway, that is critical for mediating Epac-induced sensitization. PMID:26596174

  4. Epac activation sensitizes rat sensory neurons through activation of Ras.

    Science.gov (United States)

    Shariati, Behzad; Thompson, Eric L; Nicol, Grant D; Vasko, Michael R

    2016-01-01

    Guanine nucleotide exchange factors directly activated by cAMP (Epacs) have emerged as important signaling molecules mediating persistent hypersensitivity in animal models of inflammation, by augmenting the excitability of sensory neurons. Although Epacs activate numerous downstream signaling cascades, the intracellular signaling which mediates Epac-induced sensitization of capsaicin-sensitive sensory neurons remains unknown. Here, we demonstrate that selective activation of Epacs with 8-CPT-2'-O-Me-cAMP-AM (8CPT-AM) increases the number of action potentials (APs) generated by a ramp of depolarizing current and augments the evoked release of calcitonin gene-related peptide (CGRP) from isolated rat sensory neurons. Internal perfusion of capsaicin-sensitive sensory neurons with GDP-βS, substituted for GTP, blocks the ability of 8CPT-AM to increase AP firing, demonstrating that Epac-induced sensitization is G-protein dependent. Treatment with 8CPT-AM activates the small G-proteins Rap1 and Ras in cultures of sensory neurons. Inhibition of Rap1, by internal perfusion of a Rap1-neutralizing antibody or through a reduction in the expression of the protein using shRNA does not alter the Epac-induced enhancement of AP generation or CGRP release, despite the fact that in most other cell types, Epacs act as Rap-GEFs. In contrast, inhibition of Ras through expression of a dominant negative Ras (DN-Ras) or through internal perfusion of a Ras-neutralizing antibody blocks the increase in AP firing and attenuates the increase in the evoked release of CGRP induced by Epac activation. Thus, in this subpopulation of nociceptive sensory neurons, it is the novel interplay between Epacs and Ras, rather than the canonical Epacs and Rap1 pathway, that is critical for mediating Epac-induced sensitization. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. Design of complete software GPS signal simulator with low complexity and precise multipath channel model

    Directory of Open Access Journals (Sweden)

    G. Arul Elango

    2016-09-01

    Full Text Available The need for GPS data simulators have become important due to the tremendous growth in the design of versatile GPS receivers. Commercial hardware and software based GPS simulators are expensive and time consuming. In this work, a low cost simple novel GPS L1 signal simulator is designed for testing and evaluating the performance of software GPS receiver in a laboratory environment. A typical real time paradigm, similar to actual satellite derived GPS signal is created on a computer generated scenario. In this paper, a GPS software simulator is proposed that may offer a lot of analysis and testing flexibility to the researchers and developers as it is totally software based primarily running on a laptop/personal computer without the requirement of any hardware. The proposed GPS simulator allows provision for re-configurability and test repeatability and is developed in VC++ platform to minimize the simulation time. It also incorporates Rayleigh multipath channel fading model under non-line of sight (NLOS conditions. In this work, to efficiently design the simulator, several Rayleigh fading models viz. Inverse Discrete Fourier Transform (IDFT, Filtering White Gaussian Noise (FWFN and modified Sum of Sinusoidal (SOS simulators are tested and compared in terms of accuracy of its first and second order statistical metrics, execution time and the later one is found to be as the best appropriate Rayleigh multipath model suitable for incorporating with GPS simulator. The fading model written in ‘MATLAB’ engine has been linked with software GPS simulator module enable to test GPS receiver’s functionality in different fading environments.

  6. The use of vestibular models for design and evaluation of flight simulator motion

    Science.gov (United States)

    Bussolari, Steven R.; Young, Laurence R.; Lee, Alfred T.

    1989-01-01

    Quantitative models for the dynamics of the human vestibular system are applied to the design and evaluation of flight simulator platform motion. An optimal simulator motion control algorithm is generated to minimize the vector difference between perceived spatial orientation estimated in flight and in simulation. The motion controller has been implemented on the Vertical Motion Simulator at NASA Ames Research Center and evaluated experimentally through measurement of pilot performance and subjective rating during VTOL aircraft simulation. In general, pilot performance in a longitudinal tracking task (formation flight) did not appear to be sensitive to variations in platform motion condition as long as motion was present. However, pilot assessment of motion fidelity by means of a rating scale designed for this purpose, were sensitive to motion controller design. Platform motion generated with the optimal motion controller was found to be generally equivalent to that generated by conventional linear crossfeed washout. The vestibular models are used to evaluate the motion fidelity of transport category aircraft (Boeing 727) simulation in a pilot performance and simulator acceptability study at the Man-Vehicle Systems Research Facility at NASA Ames Research Center. Eighteen airline pilots, currently flying B-727, were given a series of flight scenarios in the simulator under various conditions of simulator motion. The scenarios were chosen to reflect the flight maneuvers that these pilots might expect to be given during a routine pilot proficiency check. Pilot performance and subjective rating of simulator fidelity was relatively insensitive to the motion condition, despite large differences in the amplitude of motion provided. This lack of sensitivity may be explained by means of the vestibular models, which predict little difference in the modeled motion sensations of the pilots when different motion conditions are imposed.

  7. Selection, specification, design and use of various nuclear power plant training simulators

    International Nuclear Information System (INIS)

    Bruno, R.; Neboyan, V.

    1997-01-01

    Several IAEA guidance publications on safety culture and NPP personnel training consider the role of training and particularly the role of simulators training to enhance the safety of NPP operations. Initially, the focus has been on full-scope simulators for the training of main control room operators. Presently, a wide range of different types of simulators are used at training center. Several guidance publications concerning development and use of full-scope simulators are currently available. Experience shows that other types of simulators are also effective training tools that allow simulator training for a broader range of target groups and training objectives. Based on this need, the IAEA undertook a project to prepare a report on selection, specification, design and use of various training simulators, which provides guidance to training centers and suppliers for proper selection, specification, design, and use of various form of simulators. In addition, it provides examples of their use in several Member States. This paper presents a summary of the IAEATECDOC publication on the subject. (author)

  8. Bridging the Design-Science Gap with Tools: Science Learning and Design Behaviors in a Simulated Environment for Engineering Design

    Science.gov (United States)

    Chao, Jie; Xie, Charles; Nourian, Saeid; Chen, Guanhua; Bailey, Siobhan; Goldstein, Molly H.; Purzer, Senay; Adams, Robin S.; Tutwiler, M. Shane

    2017-01-01

    Many pedagogical innovations aim to integrate engineering design and science learning. However, students frequently show little attempt or have difficulties in connecting their design projects with the underlying science. Drawing upon the Cultural-Historical Activity Theory, we argue that the design tools available in a learning environment…

  9. Multidisciplinary Simulation of Graphite-Composite and Cermet Fuel Elements for NTP Point of Departure Designs

    Science.gov (United States)

    Stewart, Mark E.; Schnitzler, Bruce G.

    2015-01-01

    This paper compares the expected performance of two Nuclear Thermal Propulsion fuel types. High fidelity, fluid/thermal/structural + neutronic simulations help predict the performance of graphite-composite and cermet fuel types from point of departure engine designs from the Nuclear Thermal Propulsion project. Materials and nuclear reactivity issues are reviewed for each fuel type. Thermal/structural simulations predict thermal stresses in the fuel and thermal expansion mis-match stresses in the coatings. Fluid/thermal/structural/neutronic simulations provide predictions for full fuel elements. Although NTP engines will utilize many existing chemical engine components and technologies, nuclear fuel elements are a less developed engine component and introduce design uncertainty. Consequently, these fuel element simulations provide important insights into NTP engine performance.

  10. Design optimization of pixel sensors using device simulations for the phase-II CMS tracker upgrade

    Science.gov (United States)

    Jain, G.; Bhardwaj, A.; Dalal, R.; Eber, R.; Eichorn, T.; Fernandez, M.; Lalwani, K.; Messineo, A.; Palomo, F. R.; Peltola, T.; Printz, M.; Ranjan, K.; Villa, I.; Hidalgo, S.; CMS Collaboration

    2016-07-01

    In order to address the problems caused by the harsh radiation environment during the high luminosity phase of the LHC (HL-LHC), all silicon tracking detectors (pixels and strips) in the CMS experiment will undergo an upgrade. And so to develop radiation hard pixel sensors, simulations have been performed using the 2D TCAD device simulator, SILVACO, to obtain design parameters. The effect of various design parameters like pixel size, pixel depth, implant width, metal overhang, p-stop concentration, p-stop depth and bulk doping density on the leakage current and critical electric field are studied for both non-irradiated as well as irradiated pixel sensors. These 2D simulation results of planar pixels are useful for providing insight into the behaviour of non-irradiated and irradiated silicon pixel sensors and further work on 3D simulation is underway.

  11. Design optimization of pixel sensors using device simulations for the phase-II CMS tracker upgrade

    International Nuclear Information System (INIS)

    Jain, G.; Bhardwaj, A.; Dalal, R.; Eber, R.; Eichorn, T.; Fernandez, M.; Lalwani, K.; Messineo, A.; Palomo, F.R.; Peltola, T.; Printz, M.; Ranjan, K.; Villa, I.; Hidalgo, S.

    2016-01-01

    In order to address the problems caused by the harsh radiation environment during the high luminosity phase of the LHC (HL-LHC), all silicon tracking detectors (pixels and strips) in the CMS experiment will undergo an upgrade. And so to develop radiation hard pixel sensors, simulations have been performed using the 2D TCAD device simulator, SILVACO, to obtain design parameters. The effect of various design parameters like pixel size, pixel depth, implant width, metal overhang, p-stop concentration, p-stop depth and bulk doping density on the leakage current and critical electric field are studied for both non-irradiated as well as irradiated pixel sensors. These 2D simulation results of planar pixels are useful for providing insight into the behaviour of non-irradiated and irradiated silicon pixel sensors and further work on 3D simulation is underway.

  12. Design optimization of pixel sensors using device simulations for the phase-II CMS tracker upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Jain, G., E-mail: geetikajain.hep@gmail.com [CDRST, Department of Physics & Astrophysics, University of Delhi, Delhi (India); Bhardwaj, A.; Dalal, R. [CDRST, Department of Physics & Astrophysics, University of Delhi, Delhi (India); Eber, R. [Institute fur Experimentelle Kernphysik (Germany); Eichorn, T. [Deutsches Elektronen Synchrotron (Germany); Fernandez, M. [Instituto de Fisica de Cantabria (Spain); Lalwani, K. [CDRST, Department of Physics & Astrophysics, University of Delhi, Delhi (India); Messineo, A. [Universita di Pisa & INFN sez. di Pisa (Italy); Palomo, F.R. [Escuela Superior de Ingenieros, Universidad de Sevilla (Spain); Peltola, T. [Helsinki Institute of Physics (Finland); Printz, M. [Institute fur Experimentelle Kernphysik (Germany); Ranjan, K. [CDRST, Department of Physics & Astrophysics, University of Delhi, Delhi (India); Villa, I. [Instituto de Fisica de Cantabria (Spain); Hidalgo, S. [Instituto de Microelectronica de Barcelona, Centro Nacional de Microelectronica (Spain)

    2016-07-11

    In order to address the problems caused by the harsh radiation environment during the high luminosity phase of the LHC (HL-LHC), all silicon tracking detectors (pixels and strips) in the CMS experiment will undergo an upgrade. And so to develop radiation hard pixel sensors, simulations have been performed using the 2D TCAD device simulator, SILVACO, to obtain design parameters. The effect of various design parameters like pixel size, pixel depth, implant width, metal overhang, p-stop concentration, p-stop depth and bulk doping density on the leakage current and critical electric field are studied for both non-irradiated as well as irradiated pixel sensors. These 2D simulation results of planar pixels are useful for providing insight into the behaviour of non-irradiated and irradiated silicon pixel sensors and further work on 3D simulation is underway.

  13. Design and simulation experimental study of bracket plates in steam generator for AC600 PWR

    International Nuclear Information System (INIS)

    Zhang Fuyuan; Zhang Wenqi; Ji Quankai; Zeng Xi; Xie Yongyao

    1998-01-01

    Seven-holes type bracket plate at the inlet nozzle and three-holes taper bracket plate at outlet nozzle are designed. According to 'local form and structure change' simulation theory, hydraulic models and simulators for the simulative experiments are designed. Taking water as the medium, the simulative experiments have been completed at the room temperature. The ζ-Re curves (here, ζ is the local pressure loss coefficient at the nozzles after the bracket plates are installed and Re is Reynolds number) have been got. Based on the experimental results, the computation and the analysis have been shown that. If the bracket plates are used in the steam generator (SG) of AC600 PWR, the pressure drop of primary side in the SG is about 14 percent higher than that of the 55/19 B style SG

  14. THE USE OF HEC-RAS MODELLING IN FLOOD RISK ANALYSIS

    Directory of Open Access Journals (Sweden)

    IOSUB MARINA

    2015-03-01

    Full Text Available The fact that, in the Ozana drainage basin, most of the people have built their homes in the river valley, determines that a study focused on identifying the areas exposed to hydrological risk is vital, mostly in the development decisions for villages and in the creation of management plans for emergency situations. This study analyses the mapping methodology of the flood prone areas in the middle and lower sector of the Pluton river, which is a tributary of Ozana river, in its upper sector. In order to correctly draw the flood risk maps, the HEC-RAS method has been used, together with the HEC-GeoRAS extension, in ArcGIS. The results that have been obtained, correlate with the field situation in a very high proportion: for a 1% occurance flood, almost 123 households have been damaged, and according to the simulation, a number of 147 buildings have been damaged, therefore other probabilities (that overcome the 1% situation can be used for similar simulations.

  15. Development of Inundation Map for Hypothetical Asa Dam Break using HEC-RAS and ARC GIS

    Directory of Open Access Journals (Sweden)

    O. S. Balogun

    2017-12-01

    Full Text Available Asa Dam in Ilorin, Nigeria was constructed in the1980s. The dam made of earth material has a length of 507 meters and height of 27 meters. The maximum capacity of the impoundment during the raining season is approximately 43 x 106 m3. Years after construction, tremendous physical development is taking place along the river channel starting from the dam axis towards downstream for a distance of approximately 12 km. It is estimated that several thousands of people are currently living and performing various activities within the vicinity of the river channel. It is therefore necessary to evaluate the risk involved in case of a possible dam break disaster. In view of this, a hypothetical dam break scenario was studied and analyzed using Hydrologic Engineering Center’s River Analysis System computer model. Unsteady flow simulation was performed using geometric data obtained from Digital Terrain Model with 100-year, 24 hr flow event. The HEC-RAS was used in concert with HEC-GeoRAS to assess the flood hazard along the approximately 12 km river channel. The simulated water surface elevations were exported to Arc GIS to produce an inundation map that graphically indicates the extent of the flood hazard. The results show that some important locations such as industrial, residential, motor parks, recreational and places of worship along the river length are prone to significant flood impact. This map serves as an input for emergency preparation programme in the event of the dam break.

  16. Ras Umm Sidd Oxygen Isotope (delta 18O) Data for 1750 to 1995

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Ras Umm Sidd bimonthly coral oxygen isotope data (coral core RUS-95). Notes on the data: File (Ras Umm Sidd d18O.txt.) includes columns for Year AD (bimonthly...

  17. Watershed Analysis with the Hydrologic Engineering Center's River Analysis System (HEC-RAS)

    National Research Council Canada - National Science Library

    Goodell, Christopher R; Brunner, Gary W

    2004-01-01

    The objectives of this document are to provide a general description of the HEC-RAS model, its capabilities and limitations, data requirements, traditional and innovative methods for HEC-RAS hydraulic...

  18. Radiosensitivity and ras oncogene expression in preneoplastic rat tracheal epithelial cells

    International Nuclear Information System (INIS)

    Thomassen, D.G.; Wuensch, S.A.; Kelly, G.

    1988-01-01

    The sensitivity of preneoplastic rat tracheal epithelial (RTE) cells to the cytotoxic effects of high- and low-LET radiation, and the modulating effect of the viral ras oncogene on this sensitivity were determined. Two lines of preneoplastic RTE cells have the same responsiveness to high-LET radiation, but differ in their responsiveness to a transfected ras oncogene and in their sensitivities to low-LET radiation. Cells that respond to ras by becoming neoplastic are more resistant to the cytotoxic effects of low-LET radiation than cells that are not transformable by ras. The radiosensitivity of ras-responsive cells was not altered by transfection with ras. However, transfection of ras-non responsive cells with ras decreased their sensitivity to low-LET radiation. These data suggest that the ability of cells to repair radiation damage changes as they progress to neoplasia. (author)

  19. Characterization of sur-2, a Novel Ras-Mediated Signal Transduction Component in C. elegans

    National Research Council Canada - National Science Library

    DesJardins, Edward

    1998-01-01

    ... (oncogenes). A subset of proto-oncogenes comprise the RAS signal transduction pathway. Vulval development in the nematode worm Caenorhabditis elegans is controlled by a RAS signal transduction pathway...

  20. Characterization of sur-2, a Novel Ras-Mediated Signal Transduction Component in C. elegans

    National Research Council Canada - National Science Library

    DesJardins, Edward

    1999-01-01

    ... (oncogenes). A subset of proto-oncogenes comprise the RAS signal transduction pathway. Vulval development in the nematode worm Caenorhabditis elegans is controlled by a RAS signal transduction pathway. C...