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Sample records for raphael meldola frs

  1. Chemist, entomologist, Darwinian, and man of affairs: Raphael Meldola and the making of a scientific career.

    Science.gov (United States)

    Gay, Hannah

    2010-01-01

    Raphael Meldola FRS (1849-1915) was professor of chemistry at the City and Guilds Technical College in Finsbury. He was a colleague and close friend of Silvanus Phillips Thompson FRS (1851-1916), the college principal and professor of physics. This paper follows an earlier one on Thompson and the making of his career. It is intended to illustrate further the ways in which scientists of Meldola and Thompson's generation gained advancement within the scientific community. Meldola had interests beyond chemistry, including a serious interest in field entomology. In this he had several well-known mentors including Alfred Russel Wallace and Charles Darwin. The paper, which includes much new information derived from archival work, is presented as six thematic narratives related, among other things, to chemical and technical education, dye chemistry, the Royal Society solar eclipse expedition of 1875, natural history and Darwinism, field clubs, learned societies, and the honouring of scientists. Together these narratives illustrate a generalist/voluntarist career pattern that came to an end with the First World War.

  2. Facility Registry Service (FRS)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Facility Registry Service (FRS) provides an integrated source of comprehensive (air, water, and waste) environmental information about facilities across EPA,...

  3. Walter Frank Raphael Weldon (1860-1906)

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 22; Issue 6. Walter Frank Raphael Weldon (1860-1906). Amitabh Joshi ... Author Affiliations. Amitabh Joshi1. Evolutionary Biology Laboratories, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru 560 064, India, ...

  4. Malcolm Roy Clarke, FRS

    National Research Council Canada - National Science Library

    Rodhouse, Paul G.K; Lu, Chung-Cheng; Roper, Clyde F.E

    2015-01-01

      Malcolm Roy Clarke, FRS (1930-2013) made lasting contributions to cephalopod biology through his productive research programme, his commitment to furthering cephalopod biology and his congenial spirit...

  5. EPA Facility Registry Service (FRS): ALL FRS INTERESTS LAYER

    Data.gov (United States)

    U.S. Environmental Protection Agency — This data provides location and attribute information on all facilities in EPA's Facility Registry Service (FRS) for a internet web feature service . The FRS is an...

  6. Raphael's Poetics: Art and Poetry in High Renaissance Rome

    NARCIS (Netherlands)

    Rijser, D.

    2012-01-01

    De relatie tussen woord en beeld, de twee hoofddragers van onze culturele traditie, vormt het speerpunt van Raphael's Poetics, dat zich concentreert op het werk van de schilder Raphael uit Urbino (1483-1520) en de literatuur die in zijn kringen werd gelezen en geproduceerd. Waar de Neolatijnse

  7. Comparison of Meldola's Blue Staining and Hatching Assay with Potato Root Diffusate for Assessment of Globodera sp. Egg Viability.

    Science.gov (United States)

    Kroese, Duncan; Zasada, Inga A; Ingham, Russell E

    2011-09-01

    Laboratory-based methods to test egg viability include staining with Meldola's Blue and/or juvenile (J2) hatching assays using potato root diffusate (PRD). These two methods have not been tested under identical conditions to directly compare their assessments of Globodera egg viability. Using two bioassay strategies, cysts from a Globodera sp. population found in Oregon were subjected to both viability assessment methods. In strategy one, intact cysts were first stained with Meldola's Blue (primary staining) and eggs were then transferred to PRD (secondary hatching). In the second strategy, intact cysts were exposed to PRD (primary hatching) and then unhatched eggs were transferred to Meldola's Blue (secondary staining). Two different cohorts of cysts were evaluated using these experimental strategies: cohort 1 was comprised of cysts produced on potato in the greenhouse that exhibited low hatch when exposed to PRD and cohort 2 consisted of field-collected cysts whose eggs yielded significant hatch when exposed to PRD. Percentage viability was calculated and is expressed as the number of hatched J2 or unstained eggs/total number of eggs within a cyst. With field-produced cysts, primary staining with Meldola's Blue and hatching with PRD produced similar viability estimates, with averages of 74.9% and 76.3%, respectively. In contrast, with greenhouse-produced cysts the two methods yielded much lower and unequal estimates 32.4% to 2.2%, respectively for primary hatching and staining methods. In addition, J2 hatch from unstained (viable) greenhouse-produced eggs was 13.7% after secondary exposure to PRD compared to 61.5% for field-produced eggs. The majority of eggs remaining unhatched after primary exposure to PRD (> 87%) stained with Meldola's Blue regardless of cyst cohort. Staining with Meldola's Blue provided a conservative assessment of egg viability compared to hatch assay with PRD regardless of diapause.

  8. Il Maestro della Commenda di Meldola e la magione ospitaliera di San Giovanni Battista

    Directory of Open Access Journals (Sweden)

    Paolo Cova

    2012-02-01

    Full Text Available L’intervento propone, attraverso l’indagine di alcuni dipinti di area forlivese, una prima ricostruzione della personalità di un interessante interprete locale del XV secolo, provvisoriamente denominato Maestro della Commenda di Meldola. Lo studio, parte integrante della mia tesi di dottorato, prende le mosse dall’analisi dell’affresco dell’Oratorio di San Giovanni Battista a Meldola, per poi allargarsi ad altre emergenze del territorio circostante, fino ai lacerti pittorici emersi nella chiesa della Santissima Trinità di Forlì. Nella prima parte dell’articolo viene ricostruita la storia dell’Oratorio di San Giovanni Battista presso Villa Fronticelli a Meldola: già magione templare di Santa Maria Biacque, nel 1312, in seguito al processo ai templari, passò alle dipendenze della precettoria dei cavalieri gerosolimitani di San Giovanni di Palareto. La realizzazione dell’affresco deve essere probabilmente inserita all’interno dei lavori di ristrutturazione intrapresi dai giovanniti dopo la metà del XV secolo. Nella seconda parte dell’articolo invece si procede alle indagini tecniche e stilistiche relative alla pittura murale che rappresenta la Madonna col Bambino e San Giovanni Battista. L’affresco mutilo è opera di un interessante maestro che agisce nella sfera del tardogotico locale, mostrando però tenui accenti rinascimentali caratteristici alla pittura forlivese tra sesto e settimo decennio del Quattrocento. Muovendo dalle ricerche di Anna Tambini e Giordani Viroli, attraverso l’analisi di diverse testimonianze del territorio, viene così proposta la ricostruzione di un corpus pittorico caratterizzato da stringenti affinità stilistiche, che, confermando l’appartenenza del suo anonimo pittore ad un milieu stilistico caro ad altri interpreti forlivesi del periodo, come il Maestro di Castrocaro o il Maestro di San Pier Damiani, aiuta ulteriormente a chiarire il panorama artistico romagnolo all’avvento della

  9. "How like an Angel": Self-Fashioning in Pico della Mirandola and Raphael

    NARCIS (Netherlands)

    Rijser, D.; Rijser, D.; Treffers, B.

    2009-01-01

    The projected image of the philosopher Pico della Mirandola and the painter Raphael share a common trait: both were seen by contemporaries as angels. The role Pico and Raphael themselves played in the establishment of this assimilation is discussed, as is the theological and intellectual background

  10. EPA Facility Registry Service (FRS): CAMDBS

    Science.gov (United States)

    This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link to the Clean Air Markets Division Business System (CAMDBS). Administered by the EPA Clean Air Markets Division, within the Office of Air and Radiation, CAMDBS supports the implementation of market-based air pollution control programs, including the Acid Rain Program and regional programs designed to reduce the transport of ozone. FRS identifies and geospatially locates facilities, sites or places subject to environmental regulations or of environmental interest. Using vigorous verification and data management procedures, FRS integrates facility data from EPA's national program systems, other federal agencies, and State and tribal master facility records and provides EPA with a centrally managed, single source of comprehensive and authoritative information on facilities. This data set contains the subset of FRS integrated facilities that link to CAMDBS facilities once the CAMDBS data has been integrated into the FRS database. Additional information on FRS is available at the EPA website https://www.epa.gov/enviro/facility-registry-service-frs.

  11. EPA Facility Registry Service (FRS): Power Plants

    Science.gov (United States)

    This GIS dataset contains data on power plants, based on the Energy Information Administration's EIA-860 dataset and supplemented with data from EPA's Facility Registry Service (FRS) compiled from various EPA programs.

  12. EPA Facility Registry Service (FRS): TRI

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  13. EPA Facility Registry Service (FRS): BIA

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  14. EPA Facility Registry Service (FRS): LANDFILL

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of non-hazardous waste...

  15. EPA Facility Registry Service (FRS): RADINFO

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  16. EPA Facility Registry Service (FRS): RCRA

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of hazardous waste...

  17. EPA Facility Registry Service (FRS): OIL

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link to the Oil...

  18. EPA Facility Registry Service (FRS): RMP

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  19. EPA Facility Registry Service (FRS): SDWIS

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  20. EPA Facility Registry Service (FRS): ACRES

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service consists of location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of sites that link to...

  1. EPA Facility Registry System (FRS): NCES

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link...

  2. EPA Facility Registry Service (FRS): NEI

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  3. EPA Facility Registry Service (FRS): ICIS

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  4. EPA Facility Registry Service (FRS): CAMDBS

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  5. EPA Facility Registry Service (FRS): RBLC

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  6. EPA Facility Registry System (FRS): NEPT

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link...

  7. EPA Facility Registry Service (FRS): NCDB

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  8. EPA Facility Registry Service (FRS): BRAC

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  9. Unique Spectrometer Experiments with the Super-FRS at FAIR

    Science.gov (United States)

    Äystö, J.; Behr, K.-H.; Benlliure, J.; Bracco, A.; Egelhof, P.; Fomichev, A.; Gales, S.; Geissel, H.; Grigorenko, L. V.; Harakeh, M. N.; Hayano, R.; Heinz, S.; Itahashi, K.; Jokinen, A.; Kalantar, N.; Kanungo, R.; Khanzadeev, A. V.; Lenske, H.; Mukha, I.; Nociforo, C.; Ong, H. J.; Pfützner, M.; Pietri, S.; Pivovarov, Y.; Plass, W.; Prochazka, A.; Purushothaman, S.; Saito, T.; Scheidenberger, C.; Simon, H.; Tanihata, I.; Toki, H.; Weick, H.; Winfield, J. S.; Winkler, M.; Zamfir, V.

    The Super-FRS at FAIR is a powerful superconducting in-flight separator and also a versatile high-resolution spectrometer system for exotic nuclei over a large energy range equivalent to a maximum magnetic rigidity of 20 Tm. In this contribution we present the physics program of the Super-FRS Collaboration. This program is partially based on the previous experimental results obtained with the FRS of GSI, but will also extend the research to directions not considered before.

  10. 7 CFR 1744.66 - The financial requirement statement (FRS).

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false The financial requirement statement (FRS). 1744.66... TELEPHONE LOANS Advance and Disbursement of Funds § 1744.66 The financial requirement statement (FRS). (a... on copies of invoices from the other utility. (2) Engineering—(i) Preloan engineering. Based on a...

  11. Recent Results from Frs Experiments with Exotic Nuclei Produced with Uranium Projectiles and Perspectives with the Super-Frs

    Science.gov (United States)

    Geissel, H.; Chen, L.; Dickel, T.; Farinon, F.; Dillmann, I.; Knöbel, R.; Kurcewicz, J.; Mukha, I.; Münzenberg, G.; Nociforo, C.; Patyk, Z.; Pietri, S.; Plass, W. R.; Prochazka, A.; Scheidenberger, C.; Takechi, M.; Weick, H.; Winfield, J. S.; Winkler, M.

    2013-06-01

    Relativistic exotic nuclei have been produced via uranium projectile fragmentation and fission and investigated with the in-flight separator FRS directly, or in combination with either the storage-cooler ring ESR or the FRS Ion Catcher. 60 neutron-rich isotopes have been discovered in the element range from Nd to Pt and their production cross sections have been measured. In another experimental campaign the fragments were separated in flight and injected into the storage-cooler ring ESR for accurate mass and lifetime measurements. Pioneering experiments have been carried out with the FRS Ion Catcher. Results from these different FRS experiments will be presented in this overview together with perspectives for the next-generation facility Super-FRS.

  12. EPA Facility Registry Service (FRS): ER_RMP

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link...

  13. EPA Facility Registry Service (FRS): RCRA_TSD

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of Hazardous Waste...

  14. EPA Facility Registry Service (FRS): ER_TSCA

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link...

  15. EPA Facility Registry Service (FRS): ER_WWTP_NPDES

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of Waste Water Treatment...

  16. EPA Facility Registry Service (FRS): RCRA_INACTIVE

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of hazardous waste...

  17. EPA Facility Registry Service (FRS): AIRS_AFS

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  18. EPA Facility Registry Service (FRS): ER_CERCLIS

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link...

  19. EPA Facility Registry Service (FRS): Wastewater Treatment Plants

    Data.gov (United States)

    U.S. Environmental Protection Agency — This GIS dataset contains data on wastewater treatment plants, based on EPA's Facility Registry Service (FRS), EPA's Integrated Compliance Information System (ICIS)...

  20. EPA Facility Registry Service (FRS): AIRS_AFS_MAJOR

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  1. EPA Facility Registry Service (FRS): Facility Interests Dataset

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service consists of location and facility identification information from EPA's Facility Registry Service (FRS) for all sites that are available in...

  2. EPA Facility Registry Service (FRS): Facility Interests Dataset - Intranet

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service consists of location and facility identification information from EPA's Facility Registry Service (FRS) for all sites that are available in...

  3. EPA Facility Registry Service (FRS): Facility Interests Dataset Download

    Data.gov (United States)

    U.S. Environmental Protection Agency — This downloadable data package consists of location and facility identification information from EPA's Facility Registry Service (FRS) for all sites that are...

  4. EPA Facility Registry Service (FRS): ER_EPLAN

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link...

  5. EPA Facility Registry Service (FRS): CERCLIS_NPL

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that are...

  6. EPA Facility Registry Service (FRS): RCRA_LQG

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  7. EPA Facility Registry Service (FRS): PCS_NPDES

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  8. EPA Facility Registry Service (FRS): AIRS_AQS

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  9. EPA Facility Registry Service (FRS): ER_TRI

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link...

  10. EPA Facility Registry Service (FRS): ER_RCRATSD

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link...

  11. EPA Facility Registry Service (FRS): RCRA_ACTIVE

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of active hazardous...

  12. EPA Facility Registry Service (FRS): RCRA_TRANS

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  13. Environmental Protection Agency (EPA) Facility Registry Service (FRS) Power Plants

    Data.gov (United States)

    Department of Homeland Security — This GIS dataset contains data on wastewater treatment plants, based on EPA's Facility Registry Service (FRS) and NPDES, along with Clean Watersheds Needs Survey...

  14. EPA Facility Registry Service (FRS): PCS_NPDES_MAJOR

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that are...

  15. EPA Facility Registry Service (FRS): ER_FRP

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link to Facility...

  16. EPA Facility Registry Service (FRS): Facility Interests Dataset - Intranet Download

    Data.gov (United States)

    U.S. Environmental Protection Agency — This downloadable data package consists of location and facility identification information from EPA's Facility Registry Service (FRS) for all sites that are...

  17. O arranjo e o improviso de Raphael Rabello sobre Odeon de Ernesto Nazareth

    OpenAIRE

    Nunes,Alvimar Liberato; Borém,Fausto

    2014-01-01

    Estudo comparativo entre os procedimentos composicionais de Ernesto Nazareth (1863-1934) no original de Odeon para piano de 1910 (NAZARETH e MAURÍCIO, 1968) e as práticas de performance e de arranjo pelo violonista de choro Raphael Rabello (1962-1995) no seu arranjo gravado em áudio comercial (NAZARETH e RABELLO, 1991) e em seu improviso gravado em vídeo não-comercial (RABELLO e NAZARETH, 1991). As análises das transcrições dessas gravações (NAZARETH e RABELLO, 2014; RABELLO e NAZARETH, 2014)...

  18. RAPHAEL SAMÚ: Experiências do muralismo no Espírito Santo

    OpenAIRE

    GONCALVES, M. B.

    2014-01-01

    A proposta deste estudo é investigar o processo de criação do artista plástico brasileiro Raphael Samú, tendo como recorte sua obra em mosaico mural, mais especificamente o mural presente na entrada da Universidade Federal do Espírito Santo UFES, em Vitória - Espírito Santo. Para tal, investigaremos através dos pressupostos da Crítica Genética e da Crítica Inferencial quais foram os caminhos tomados pelo artista durante a confecção de tal obra, apontando assim a intencionalidade do projet...

  19. Super-FRS Target Area Remote Handling: Scenario and Development

    Directory of Open Access Journals (Sweden)

    Luis Miguel Orona

    2013-11-01

    Full Text Available The Super-FRS, Superconducting Fragment Separator, is a unique machine that presents several challenging technical problems. One of these is regarding how to conduct maintenance in the target area where high levels of radiation will be generated and human access is forbidden. To address this problem the use of a remote maintenance system is foreseen. The objective of this paper is to develop a systems engineering (SE research and development (R&D approach suitable to develop the Super-FRS Target Area Remote Maintenance Systems (TARMS and the RH design adaptation of the components in the target area. The Super-FRS target area is described in detail in order to introduce the need for a remote maintenance system. Components in the target area are classified by adopting ITER RH maintenance classification. The general scenario of remote handling and the current target area remote maintenance system are described. Finally, the proposed systems engineering approach is presented.

  20. Spatial vision anomalies in Renaissance art: Raphael, Giorgione, Dürer.

    Science.gov (United States)

    Weale, Robert

    2008-01-01

    Two-dimensional views of three-dimensional space are based on conventions. Renaissance perspectival drawing invented by Brunelleschi is one of them. It caused difficulties to fifteenth and sixteenth century and later artists, although readily taken up by those understanding mathematics. Raphael was amongst those who did not seem to have understood some of its elements: this is illustrated in the first section. The second addresses the question of whether a squint may manifest in an artist's work. Giorgione's ocular anomaly was well documented by several of his self-portraits, and reference is made to some of his paintings with a special analysis of The Tempest. The final section deals with chromatic stereoscopy, with particular reference to the work of Dürer. His apparently anomalous spatial sense is tentatively explained with the suggestion that he may have suffered from a defect of colour vision (protanomaly).

  1. EPA Facility Registry Service (FRS): Facility Interests Dataset

    Science.gov (United States)

    This web feature service consists of location and facility identification information from EPA's Facility Registry Service (FRS) for all sites that are available in the FRS individual feature layers. The layers comprise the FRS major program databases, including:Assessment Cleanup and Redevelopment Exchange System (ACRES) : brownfields sites ; Air Facility System (AFS) : stationary sources of air pollution ; Air Quality System (AQS) : ambient air pollution data from monitoring stations; Bureau of Indian Affairs (BIA) : schools data on Indian land; Base Realignment and Closure (BRAC) facilities; Clean Air Markets Division Business System (CAMDBS) : market-based air pollution control programs; Comprehensive Environmental Response, Compensation, and Liability Information System (CERCLIS) : hazardous waste sites; Integrated Compliance Information System (ICIS) : integrated enforcement and compliance information; National Compliance Database (NCDB) : Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and the Toxic Substances Control Act (TSCA); National Pollutant Discharge Elimination System (NPDES) module of ICIS : NPDES surface water permits; Radiation Information Database (RADINFO) : radiation and radioactivity facilities; RACT/BACT/LAER Clearinghouse (RBLC) : best available air pollution technology requirements; Resource Conservation and Recovery Act Information System (RCRAInfo) : tracks generators, transporters, treaters, storers, and disposers of haz

  2. Yiorgos Kalogeras on H. Raphael-Hernandez’s The Utopian Aesthetics of Three African American Women (Toni Morrison, Gloria Naylor, Judie Dash.

    Directory of Open Access Journals (Sweden)

    2009-11-01

    Full Text Available Heike Raphael-Hernandez. The Utopian Aesthetics of Three African American Women (Toni Morrison, Gloria Naylor, Judie Dash. The Principles of Hope. The Edwin Mellen Press, 2008. Viii + pp. 173.Dr Heike Raphael-Hernandez’s book focuses on a close reading of two novels and a movie script. It also discusses briefly several other novels by African American women writers who have published their work since the 1960s. Many among these writers are already considered as major voices and their work ha...

  3. The calembour in Rabbi Raphael Aharon Monsonego’s “Neot midbar”

    Directory of Open Access Journals (Sweden)

    Lavi, Tamar

    2015-06-01

    Full Text Available Rabbi Raphael Aharon Monsonego was a Moroccan rabbi who lived in the 18th-19th centuries. His literary creation is extensive, and apart from halachic texts he wrote a series of poems that are characterized by abundant use of the calembour technique. The calembour (in English, pun is a specific type of allusion used by North African Jewish poets and writers. Like all allusions it is based on “a meeting of two texts, one implicit – i.e., in our consciousness and memory, and the other explicit – i.e., in the actual text in front of us.” A calembour differs from other types of allusions in that it consists of “phonetic and spelling changes in the words, idioms and fragmented verses in order to gain a humorous effect and other associative allusion.” Namely, in the calembour a word or phrase from a biblical or rabbinic text is presented “with a minimal change in letter or vowel etc. […] creating a witticism or a new meaning.” The author assumes, then, that the reader is able to intuitively identify the original text despite the changes made and even enjoy and appreciate the linguistic witticism since he is well-versed in the Jewish sources (especially the Hebrew Bible and halachic literature. The aim of this paper is to examine the use of the calembour in Monsonego’s poetry through several examples of its different forms and especially through the analysis of one of the poems that features a larger use of this technique: “Im omar avo ha-‘ir” (‘If I resolve to arouse lament’.R. Raphael Aharón Monsonego fue un rabino marroquí que vivió entre los siglos XVIII y XIX. Su extensa obra literaria incluye textos religiosos de la Halajá, como también poemas que se caracterizan por el frecuente recurso a la técnica del calambur, por la cual hace referencia a versos bíblicos en un contexto diferente. El calambur es un artificio lingüístico, un tipo de alusión utilizada por poetas judíos del norte de África, que est

  4. Environmental Protection Agency (EPA) Facility Registry Service (FRS) Wastewater Treatment Plants

    Data.gov (United States)

    Department of Homeland Security — This GIS dataset contains data on wastewater treatment plants, based on EPA's Facility Registry Service (FRS) and NPDES, along with Clean Watersheds Needs Survey...

  5. BFR2015 in Beijing: Scientists are becoming more concerned about FRs in indoor environment

    NARCIS (Netherlands)

    Yu, G.; de Boer, J.

    Yu, G. and J. de Boer (2016). BFR2015 in Beijing: Scientists are becoming more concerned about FRs in indoor environment. Chemosphere 150 (on line). http://dx.doi.org/10.1016/j.chemosphere.2017.01.117

  6. Safety aspects of superconducting magnets for Super-FRS

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    The Super Fragment Separator (Super FRS) is a two-stage in flight separator to be built next to the site of GSI, Darmstadt, Germany as part of FAIR (Facility for Anti-proton and Ion Research). Its purpose is to create and separate rare isotope beams and to enable the mass measurement also for very short lived nuclei. A superferric design with superconducting coils and standard iron yoke shaping the magnetic field was chosen for the magnets. The cooling will be by a liquid Helium bath. For the main dipoles only the coil is at cold for the multiplets (asemblies of quadrupoles and hgher order correctors) also the iron yoke will be in the bath. From a safety point of view the large He-volumes of more than 1000 l of the multiplets, the high design pressure of 20 bar, as well as the high inductances of the magnets up to 30 H are challenges to be considered in the design and definition of the testing procedures.

  7. Experimental program of the Super-FRS Collaboration at FAIR and developments of related instrumentation

    Energy Technology Data Exchange (ETDEWEB)

    Äystö, J. [Helsinki Institute of Physics, P.O. Box 64, 00014 Helsinki (Finland); Behr, K.-H. [GSI Helmholtzzentrum für Schwerionenforschung, 64291 Darmstadt (Germany); Benlliure, J. [Universidad de Santiago de Compostela, 15782 Santiago de Compostela (Spain); Bracco, A. [Dipartimento di Fisica, Università di Milano, 20133 Milano (Italy); Egelhof, P. [GSI Helmholtzzentrum für Schwerionenforschung, 64291 Darmstadt (Germany); Fomichev, A. [Flerov Laboratory of Nuclear Reactions, JINR, 141980 Dubna (Russian Federation); Galès, S. [Institut de Physique Nucléaire Orsay, 91406 Orsay (France); Horia Hulubei National Institute of Physics and Nuclear Engineering, P.O. Box MG6, Bucharest (Romania); Geissel, H. [GSI Helmholtzzentrum für Schwerionenforschung, 64291 Darmstadt (Germany); Justus-Liebig-Universität, 35392 Gießen (Germany); Grahn, T. [Helsinki Institute of Physics, P.O. Box 64, 00014 Helsinki (Finland); Department of Physics, University of Jyvaskyla, P.O. Box 35, 40014 Jyvaskyla (Finland); Grigorenko, L.V. [Flerov Laboratory of Nuclear Reactions, JINR, 141980 Dubna (Russian Federation); Harakeh, M.N. [KVI Center for Advanced Radiation Technology, University of Groningen, 9700 Groningen (Netherlands); Hayano, R. [Department of Physics, University of Tokyo, 113-0033 Tokyo (Japan); Heinz, S. [GSI Helmholtzzentrum für Schwerionenforschung, 64291 Darmstadt (Germany); Itahashi, K. [RIKEN Nishina Center, Wako, Saitama 351-0198 (Japan); Jokinen, A. [Helsinki Institute of Physics, P.O. Box 64, 00014 Helsinki (Finland); Department of Physics, University of Jyvaskyla, P.O. Box 35, 40014 Jyvaskyla (Finland); and others

    2016-06-01

    The physics program at the super-conducting fragment separator (Super-FRS) at FAIR, being operated in a multiple-stage, high-resolution spectrometer mode, is discussed. The Super-FRS will produce, separate and transport radioactive beams at high energies up to 1.5 AGeV, and it can be also used as a stand-alone experimental device together with ancillary detectors. Various combinations of the magnetic sections of the Super-FRS can be operated in dispersive, achromatic or dispersion-matched spectrometer ion-optical modes, which allow measurements of momentum distributions of secondary-reaction products with high resolution and precision. A number of unique experiments in atomic, nuclear and hadron physics are suggested with the Super-FRS as a stand-alone device, in particular searches for new isotopes, studies of hypernuclei, delta-resonances in exotic nuclei and spectroscopy of atoms characterized by bound mesons. Rare decay modes like multiple-proton or neutron emission and the nuclear tensor force observed in high-momentum regime can be also addressed. The in-flight radioactivity measurements as well as fusion, transfer and deep-inelastic reaction mechanisms with the slowed-down and energy-bunched fragment beams are proposed for the high-resolution and energy buncher modes at the Super-FRS.

  8. On-line commissioning of the cryogenic stopping cell for the Super-FRS

    Energy Technology Data Exchange (ETDEWEB)

    Purushothaman, Sivaji; Estrade, Alfredo; Farinon, Fabio; Kurcewicz, Jan; Lang, Johannes; Nociforo, Chiara; Pietri, Stephane; Prochazka, Andrey; Reiter, Moritz Pascal; Takechi, Maya; Winfield, John; Weick, Helmut [GSI, Darmstadt (Germany); Dendooven, Peter; Kalantar-Nayestanaki, Nasser; Ranjan, Manisha [KVI, University of Groningen (Netherlands); Dickel, Timo; Geissel, Hans; Haettner, Emma; Knoebel, Ronja; Plass, Wolfgang; Scheidenberger, Christoph [GSI, Darmstadt (Germany); Justus-Liebig-Univ., Giessen (Germany); Ebert, Jens; Jesch, Christian [Justus-Liebig-Univ., Giessen (Germany); Moore, Iain; Rinta-Antila, Sami [University of Jyvaeskylae (Finland)

    2012-07-01

    A cryogenic stopping cell developed for the low-energy branch of the Super-FRS at FAIR has been successfully commissioned in combination with a multiple-reflection time-of-flight mass spectrometer at the FRS at GSI. The stopping cell has a stopping length of 1 m and is operated at 100 mbar helium at 100 K. The helium density used in this test is several times higher than the gas densities achieved in comparable room temperature stopping cells. In-flight separated and range-focussed {sup 223}Th fragments from the FRS have been slowed down, thermalized and extracted. Results of this test and the plans for future experiments are discussed.

  9. FRS 1000, an extract of red onion peel, strongly inhibits phosphodiesterase 5A (PDE 5A).

    Science.gov (United States)

    Lines, T C; Ono, M

    2006-03-01

    As part of our ongoing search for flavonoids that are bioactive in humans, it was determined that FRS 1000, a beverage containing flavonoids extracted from onion peel, showed unexpected improvement of male sexual function. An in vitro enzyme assay clearly showed that FRS 1000 has a strong phosphodiesterase 5A (PDE 5A) inhibitory activity, which is considered to be important for treatment of erectile dysfunction. Detailed assays of each major ingredient indicated that the antioxidative flavonoid quercetin was responsible for the activity. Results also suggested that PDE 5A inhibition is not directly related to the free radical scavenging activity of flavonoids.

  10. Cryogenic distribution for radioactive secondary beam fragment separator (Super-FRS) of FAIR

    CERN Document Server

    Xiang, Y; Kauschke, M; Moritz, G; Quack, H

    2009-01-01

    We present the flow schemes for the superconducting dipoles, the superconducting multiplets (quadrupoles, hexapoles, octupoles and steering dipoles) and the corresponding feedboxes of the Super-FRS in the FAIR project. The system layout of the helium distribution for the whole separator including the three branches of the Super-FRS and the experiment caves is discussed as well. Based on the maximum cooling capacity specified for the refrigerator, the cold-down time of the multiplets which are characteristic of large cold mass (up to 37 Tons for each) has been investigated. The issues as operation conditions, quench protection and safety relief are also discussed.

  11. Technical report on the design, construction, commissioning and operation of the super-FRS of FAIR

    Energy Technology Data Exchange (ETDEWEB)

    Geissel, H.; Winkler, M.; Weick, H. [and others

    2005-04-01

    In this report the construction of the super-FRS is described. Especially described are the ion-optical lay-out, the production targets, the magnets, the beam dumps, the degrader systems and the ion catcher, detectors and data-acquisition systems, as well as the safety aspects. (HSI)

  12. Experiments at the Frontiers of Nuclear Physics: the Experimental Program of the Super-Frs Collaboration

    Science.gov (United States)

    Scheidenberger, C.; Äystö, J.; Behr, K.-H.; Benlliure, J.; Bracco, A.; Egelhof, P.; Fomichev, A.; Galès, S.; Geissel, H.; Grahn, T.; Grigorenko, L.; Harakeh, M. N.; Hayano, R.; Heinz, S.; Itahashi, K.; Jokinen, A.; Kalantar-Nayestanaki, N.; Kanungo, R.; Lenske, H.; Muenzenberg, G.; Mukha, I.; Nociforo, C.; Ong, H. J.; Pfützner, M.; Prochazka, A.; Pietri, S.; Plaß, W. R.; Purushothaman, S.; Saito, T.; Simon, H.; Tanihata, I.; Terashima, S.; Toki, H.; Trache, L.; Weick, H.; Winfield, J. S.; Winkler, M.; Zamfir, V.

    2015-06-01

    The superconducting fragment separator (Super-FRS) will be one of the main scientific instruments of the future FAIR facility. This versatile high-resolution spectrometer allows for a variety of exciting experiments in atomic, nuclear and hadron physics. Future directions are presented in this contribution.

  13. [Between research and genocide. The Nuremberg physician trials 1946/47: Raphael Lemkins point of view on human experimentation and genocide].

    Science.gov (United States)

    Weindling, Paul

    2007-01-01

    While the significance of the new concept of genocide, as introduced by the Polish émigré jurist Raphael Lemkin, has been recognised, its importance for the Nuremberg Medical Trial has been overlooked. Lemkin commented extensively on the Trial, and his views are presented here. These comments help illuminate a neglected facet of the Trial, that of eugenics and racial extermination, taken at the time as amounting to genocide. Far from neglecting eugenics as some have suggested, the eugenic component of the Trial was extensive.

  14. Adaptation and validation of a Spanish-language version of the Frontotemporal Dementia Rating Scale (FTD-FRS).

    Science.gov (United States)

    Turró-Garriga, O; Hermoso Contreras, C; Olives Cladera, J; Mioshi, E; Pelegrín Valero, C; Olivera Pueyo, J; Garre-Olmo, J; Sánchez-Valle, R

    2017-06-01

    The Frontotemporal Dementia Rating Scale (FTD-FRS) is a tool designed to aid with clinical staging and assessment of the progression of frontotemporal dementia (FTD-FRS). Present a multicentre adaptation and validation study of a Spanish version of the FRS. The adapted version was created using 2 translation-back translation processes (English to Spanish, Spanish to English) and verified by the scale's original authors. We validated the adapted version in a sample of consecutive patients diagnosed with FTD. The procedure included evaluating internal consistency, testing unidimensionality with the Rasch model, analysing construct validity and discriminant validity, and calculating the degree of agreement between the Clinical Dementia Rating scale (CDR) and FTD-FRS for FTD cases. The study included 60 patients with DFT. The mean score on the FRS was 12.1 points (SD=6.5; range, 2-25) with inter-group differences (F=120.3; df=3; P<.001). Cronbach's alpha was 0.897 and principal component analysis of residuals delivered an acceptable eigenvalue for 5 contrasts (1.6-2.7) and 36.1% raw variance. FRS was correlated with the Mini-mental State Examination (r=0.572; P<.001) and functional capacity (DAD; r=0.790; P<.001). FTD-FRS also showed a significant correlation with CDR (r=-0.641; P<.001), but we did observe variability in the severity levels; cases appeared to be less severe according to the CDR than when measured with the FTD-FRS (kappa=0.055). This process of validating the Spanish translation of the FTD-FRS yielded satisfactory results for validity and unidimensionality (severity) in the assessment of patients with FTD. Copyright © 2016 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

  15. Environmental Protection Agency (EPA) Facility Registry Service (FRS) Emergency Response (ER) Risk Management Plan (RMP) Facilities - Oil and Hazardous Materials

    Data.gov (United States)

    Department of Homeland Security — The purpose of this web feature service is to provide users with access to integrated facility information from FRS, limited to the subset of facilities that link to...

  16. The determination of the hydrodynamic diameter of magnetic particles using FRS experiment

    Energy Technology Data Exchange (ETDEWEB)

    Kopcansky, Peter [Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 043 53 Kosice (Slovakia); Timko, Milan [Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 043 53 Kosice (Slovakia)]. E-mail: timko@saske.sk; Potocova, Ivana [Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 043 53 Kosice (Slovakia); Koneracka, Martina [Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 043 53 Kosice (Slovakia); Jurikova, Alena [Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 043 53 Kosice (Slovakia); Tomasovicova, Natalia [Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 043 53 Kosice (Slovakia); Stelina, Julius [Department of Physics, University of Zilina, Velky Diel, 010 26 Zilina (Slovakia); Musil, Ctibor [Department of Physics, University of Zilina, Velky Diel, 010 26 Zilina (Slovakia); Bracinik, Juraj [Department of Physics, University of Zilina, Velky Diel, 010 26 Zilina (Slovakia)

    2005-03-15

    A new method for the determination of the size distribution of magnetic carrier systems, as well as for the proof of successful immobilization of biomolecules to magnetic particles was developed and tested. The method is based on the Forced Rayleigh Scattering (FRS) experiment, in which a diffraction concentration grating is created in a thin sample of colloidal fluid due to the absorption of an optical interference field.

  17. Radiation protection design for the Super-FRS and SIS100 at the international FAIR facility

    Science.gov (United States)

    Kozlova, Ekaterina; Sokolov, Alexey; Radon, Torsten; Lang, Rupert; Conrad, Inna; Fehrenbacher, Georg; Weick, Helmut; Winkler, Martin

    2017-09-01

    The new accelerator SIS100 and the Super-FRS will be built at the international Facility for Antiprotons and Ion Research FAIR. The synchrotron SIS100 is a core part of the FAIR facility which serves for acceleration of ions like Uranium up to 2.7 GeV/u with intensities of 3x1011 particles per second or protons up to 30 GeV with intensities of 5x1012 particles per second. The Super-FRS is a superconducting fragment separator, it will be able to separate all kinds of nuclear projectile fragments of primary heavy ion beams including Uranium with energies up to 1.5 GeV/u and intensities up to 3x1011 particles per second. During operation activation of several components, especially the production target and the beam catchers will take place. For handling of highly activated components it is foreseen to have a hot cell with connected storage place. All calculations for the optimisation of the shielding design of the SIS100, the Super-FRS and the hot cell were performed using the Monte Carlo code FLUKA, results are presented.

  18. Radiation protection design for the Super-FRS and SIS100 at the international FAIR facility

    Directory of Open Access Journals (Sweden)

    Kozlova Ekaterina

    2017-01-01

    Full Text Available The new accelerator SIS100 and the Super-FRS will be built at the international Facility for Antiprotons and Ion Research FAIR. The synchrotron SIS100 is a core part of the FAIR facility which serves for acceleration of ions like Uranium up to 2.7 GeV/u with intensities of 3x1011 particles per second or protons up to 30 GeV with intensities of 5x1012 particles per second. The Super-FRS is a superconducting fragment separator, it will be able to separate all kinds of nuclear projectile fragments of primary heavy ion beams including Uranium with energies up to 1.5 GeV/u and intensities up to 3x1011 particles per second. During operation activation of several components, especially the production target and the beam catchers will take place. For handling of highly activated components it is foreseen to have a hot cell with connected storage place. All calculations for the optimisation of the shielding design of the SIS100, the Super-FRS and the hot cell were performed using the Monte Carlo code FLUKA, results are presented.

  19. Translation, cross-cultural adaptation and applicability of the Brazilian version of the Frontotemporal Dementia Rating Scale (FTD-FRS

    Directory of Open Access Journals (Sweden)

    Thais Bento Lima-Silva

    Full Text Available ABSTRACT Background: Staging scales for dementia have been devised for grading Alzheimer's disease (AD but do not include the specific symptoms of frontotemporal lobar degeneration (FTLD. Objective: To translate and adapt the Frontotemporal Dementia Rating Scale (FTD-FRS to Brazilian Portuguese. Methods: The cross-cultural adaptation process consisted of the following steps: translation, back-translation (prepared by independent translators, discussion with specialists, and development of a final version after minor adjustments. A pilot application was carried out with 12 patients diagnosed with bvFTD and 11 with AD, matched for disease severity (CDR=1.0. The evaluation protocol included: Addenbrooke's Cognitive Examination-Revised (ACE-R, Mini-Mental State Examination (MMSE, Executive Interview (EXIT-25, Neuropsychiatric Inventory (NPI, Frontotemporal Dementia Rating Scale (FTD-FRS and Clinical Dementia Rating scale (CDR. Results: The Brazilian version of the FTD-FRS seemed appropriate for use in this country. Preliminary results revealed greater levels of disability in bvFTD than in AD patients (bvFTD: 25% mild, 50% moderate and 25% severe; AD: 36.36% mild, 63.64% moderate. It appears that the CDR underrates disease severity in bvFTD since a relevant proportion of patients rated as having mild dementia (CDR=1.0 in fact had moderate or severe levels of disability according to the FTD-FRS. Conclusion: The Brazilian version of the FTD-FRS seems suitable to aid staging and determining disease progression.

  20. DETERMINANTS OF EARLY ADOPTION OF FRS 114 (SEGMENT REPORTING IN MALAYSIA

    Directory of Open Access Journals (Sweden)

    Wan Nordin Wan Hussin

    2005-01-01

    Full Text Available This study seeks to find out whether there are systematic differences between early adopters and a matched control group of non early adopters of FRS 114 (Segment Reporting based on the following company characteristics: (1 firm size, (2 board characteristics, (3 leverage, (4 audit firm size, and (5 firm growth rate. Using a sample of 32 early adopters and without differentiating whether they disclose the required segment information in full or partially and a control group of 32 non early adopters, our findings indicate company with higher proportion of non executive directors, particularly non independent non executives, is more likely to adopt FRS 114 before the effective date. When early adopters are further classified into full or partial adopters, the result shows that full early adopters are significantly larger (in terms of total assets than non early adopters. However, when comparing between partial early adopters and non early adopters, the evidence suggests that partial early adopters are significantly smaller in size than non early adopters. We find no evidence to indicate that there are significant differences between full early adopters, partial early adopters and non early adopters in terms of board size, board leadership, independent directors, audit firm size, leverage and firm growth rate.

  1. The FRS Ion Catcher : A facility for high-precision experiments with stopped projectile and fission fragments

    NARCIS (Netherlands)

    Plass, W. R.; Dickel, T.; Purushothaman, S.; Dendooven, P.; Geissel, H.; Ebert, J.; Haettner, E.; Jesch, C.; Ranjan, M.; Reiter, M. P.; Weick, H.; Amjad, F.; Ayet, S.; Diwisch, M.; Estrade, A.; Farinon, F.; Greiner, F.; Kalantar-Nayestanaki, N.; Knoebel, R.; Kurcewicz, J.; Lang, J.; Moore, I.; Mukha, I.; Nociforo, C.; Petrick, M.; Pfuetzner, M.; Pietri, S.; Prochazka, A.; Rink, A. -K.; Rinta-Antila, S.; Schaefer, D.; Scheidenberger, C.; Takechi, M.; Tanaka, Y. K.; Winfield, J. S.; Yavor, M. I.

    2013-01-01

    At the FRS Ion Catcher at GSI, projectile and fission fragments are produced at relativistic energies, separated in-flight, range-focused, slowed down and thermalized in a cryogenic stopping cell. A multiple-reflection time-of-flight mass spectrometer (MR-TOF-MS) is used to perform direct mass

  2. The FRS Ion Catcher – A facility for high-precision experiments with stopped projectile and fission fragments

    Energy Technology Data Exchange (ETDEWEB)

    Plaß, W.R., E-mail: Wolfgang.R.Plass@exp2.physik.uni-giessen.de [II. Physikalisches Institut, Justus-Liebig-Universität Gießen, 35392 Gießen (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, 64291 Darmstadt (Germany); Dickel, T. [II. Physikalisches Institut, Justus-Liebig-Universität Gießen, 35392 Gießen (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, 64291 Darmstadt (Germany); Purushothaman, S. [GSI Helmholtzzentrum für Schwerionenforschung GmbH, 64291 Darmstadt (Germany); Dendooven, P. [KVI, University of Groningen, 9747 AA Groningen (Netherlands); Geissel, H. [II. Physikalisches Institut, Justus-Liebig-Universität Gießen, 35392 Gießen (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, 64291 Darmstadt (Germany); Ebert, J. [II. Physikalisches Institut, Justus-Liebig-Universität Gießen, 35392 Gießen (Germany); Haettner, E. [II. Physikalisches Institut, Justus-Liebig-Universität Gießen, 35392 Gießen (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, 64291 Darmstadt (Germany); Jesch, C. [II. Physikalisches Institut, Justus-Liebig-Universität Gießen, 35392 Gießen (Germany); Ranjan, M. [KVI, University of Groningen, 9747 AA Groningen (Netherlands); and others

    2013-12-15

    Highlights: • An overview of the FRS Ion Catcher experiment at GSI is given. • The FRS Ion Catcher consists of the FRS, a cryogenic stopping cell, an RF quadrupole-based beam transport and diagnostics unit and a multiple-reflection time-of-flight mass spectrometer. • Off-line tests of the stopping cell with {sup 219}Rn ions. • First on-line operation of a stopping cell for exotic nuclei at cryogenic temperatures. • First mass measurements of heavy projectile fragments using a multiple-reflection time-of-flight mass spectrometer. -- Abstract: At the FRS Ion Catcher at GSI, projectile and fission fragments are produced at relativistic energies, separated in-flight, range-focused, slowed down and thermalized in a cryogenic stopping cell. A multiple-reflection time-of-flight mass spectrometer (MR-TOF-MS) is used to perform direct mass measurements and to provide an isobarically clean beam for further experiments, such as mass-selected decay spectroscopy. A versatile RF quadrupole transport and diagnostics unit guides the ions from the stopping cell to the MR-TOF-MS, provides differential pumping, ion identification and includes reference ion sources. The FRS Ion Catcher serves as a test facility for the Low-Energy Branch of the Super-FRS at the Facility for Antiproton and Ion Research (FAIR), where the cryogenic stopping cell and the MR-TOF-MS will be key devices for the research with stopped projectile and fission fragments that will be performed with the experiments MATS and LaSpec. Off-line tests of the stopping cell yield a combined ion survival and extraction efficiency for {sup 219}Rn ions of about 30% and an extraction time of about 25 ms. The stopping cell and the MR-TOF-MS were commissioned on-line as part of the FRS Ion Catcher. For the first time, a stopping cell for exotic nuclei was operated on-line at cryogenic temperatures. Using a gas density almost two times higher than ever reached before for a stopping cell with RF ion repelling structures

  3. Online mass measurements with a Multiple-Reflection Time-of-Flight Mass Spectrometer (MR-TOF-MS) at the FRS Ion Catcher

    Energy Technology Data Exchange (ETDEWEB)

    Ebert, Jens; Greiner, Florian; Jesch, Christian; Lang, Johannes; Petrick, Martin; Reiter, Moritz P.; Rink, Ann-Kathrin; Diwisch, Marcel [JLU Giessen (Germany); Dickel, Timo; Plass, Wolfgang R.; Geissel, Hans; Haettner, Emma; Knoebel, Ronja; Scheidenberger, Christoph [JLU Giessen (Germany); GSI, Darmstadt (Germany); Ayet, Samuel; Estrade, Alfredo; Farinon, Fabio; Kurcewicz, Jan; Mukha, Ivan; Nociforo, Chiara; Pfutzner, Marek; Pietri, Stephane; Prochazka, Andrej; Purushothaman, Sivaji; Takechi, Maya; Weick, Helmut; Winfield, John [GSI, Darmstadt (Germany); Dendooven, Peter; Kalantar-Nayestanaki, Nasser [KVI, University of Groningen (Netherlands); Moore, Iain [University of Jyvaeskylae (Finland); Yavor, Mikhail I. [Russian Academy of Sci., St. Petersburg (Russian Federation)

    2013-07-01

    At the Low-Energy-Branch (LEB) of the Super-FRS at FAIR experiments with-slowed down exotic nuclei will be performed. The FRS Ion Catcher experiment at the FRS serves a test facility for the LEB. The relativistic ions are thermalized in a novel cryogenic stopping cell, extracted and transported to a MR-TOF-MS for high precision mass measurements or decay-spectroscopy. In summer 2012 direct mass measurements of U projectile fragments have been performed for the first time with a MR-TOF-MS, among then {sup 213}Rn with a half-life of only 19.5 ns.

  4. Environmental Protection Agency (EPA) Facility Registry Service (FRS) Emergency Response (ER) Toxic Substances Control Act (TSCA) Facilities - Oil and Hazardous Materials

    Data.gov (United States)

    Department of Homeland Security — The purpose of this web feature service is to provide users with access to integrated facility information from FRS, limited to the subset of facilities that link to...

  5. The FRS Ion Catcher - A facility for high-precision experiments with stopped projectile and fission fragments

    Science.gov (United States)

    Plaß, W. R.; Dickel, T.; Purushothaman, S.; Dendooven, P.; Geissel, H.; Ebert, J.; Haettner, E.; Jesch, C.; Ranjan, M.; Reiter, M. P.; Weick, H.; Amjad, F.; Ayet, S.; Diwisch, M.; Estrade, A.; Farinon, F.; Greiner, F.; Kalantar-Nayestanaki, N.; Knöbel, R.; Kurcewicz, J.; Lang, J.; Moore, I.; Mukha, I.; Nociforo, C.; Petrick, M.; Pfützner, M.; Pietri, S.; Prochazka, A.; Rink, A.-K.; Rinta-Antila, S.; Schäfer, D.; Scheidenberger, C.; Takechi, M.; Tanaka, Y. K.; Winfield, J. S.; Yavor, M. I.

    2013-12-01

    At the FRS Ion Catcher at GSI, projectile and fission fragments are produced at relativistic energies, separated in-flight, range-focused, slowed down and thermalized in a cryogenic stopping cell. A multiple-reflection time-of-flight mass spectrometer (MR-TOF-MS) is used to perform direct mass measurements and to provide an isobarically clean beam for further experiments, such as mass-selected decay spectroscopy. A versatile RF quadrupole transport and diagnostics unit guides the ions from the stopping cell to the MR-TOF-MS, provides differential pumping, ion identification and includes reference ion sources. The FRS Ion Catcher serves as a test facility for the Low-Energy Branch of the Super-FRS at the Facility for Antiproton and Ion Research (FAIR), where the cryogenic stopping cell and the MR-TOF-MS will be key devices for the research with stopped projectile and fission fragments that will be performed with the experiments MATS and LaSpec. Off-line tests of the stopping cell yield a combined ion survival and extraction efficiency for 219Rn ions of about 30% and an extraction time of about 25 ms. The stopping cell and the MR-TOF-MS were commissioned on-line as part of the FRS Ion Catcher. For the first time, a stopping cell for exotic nuclei was operated on-line at cryogenic temperatures. Using a gas density almost two times higher than ever reached before for a stopping cell with RF ion repelling structures, various 238U projectile fragments were thermalized and extracted with very high efficiency. Direct mass measurements of projectile fragments were performed with the MR-TOF-MS, among them the nuclide 213Rn with a half-life of 19.5 ms only.

  6. High-power production targets for the Super-FRS using a fast extraction scheme

    CERN Document Server

    Tahir, N A; Kojouharova, J; Roussel-Chomaz, P; Chishkine, V; Geissel, H; Hoffmann, Dieter H H; Kindler, B; Landre-Pellemoine, F; Lommel, B; Mittig, W; Münzenberg, G; Shutov, A; Weick, H; Yavor, M

    2003-01-01

    The high-power production target of the Super-FRS [H. Geissel et al., these Proceedings] will be irradiated by very intense heavy-ion beams which will be delivered from the future SIS100/200 [An International Accelerator Facility for Beams of Ions and Antiprotons, GSI-Report, 2001] synchrotron facility at the Gesellschaft fuer Schwerionenforschung (GSI) Darmstadt. This paper presents calculations of the thermodynamic and the hydrodynamic response of such a target, considering that a uranium ion beam with an energy of 1 GeV/u and an intensity of 10 sup 1 sup 2 particles will impinge within 50 ns on a solid carbon target with a thickness of 4 g/cm sup 2. Due to the high beam intensity the target may be strongly heated and could be destroyed in a single shot. The purpose of this work is to investigate with the help of two-dimensional numerical simulations how one can minimize target heating and avoid target destruction.

  7. The Art Requisitions by the French under Napoléon and the Detachment of Frescoes in Rome, with an Emphasis on Raphael

    Directory of Open Access Journals (Sweden)

    Cathleen Hoeniger

    2012-04-01

    Full Text Available La restauration des peintures italiennes du Louvre, après les spoliations napoléoniennes, a reçu une attention considérable. Cependant, la volonté simultanée des Français de détacher les fresques à Rome a peu été étudiée, alors même que le désir de s’approprier les peintures de Raphaël les avait conduit à projeter l'extraction de ses fresques au Vatican. Le transfert des retables de Raphaël à Paris et le détachement de fresques par les disciples proches de Raphaël et de Michel-Ange à Rome sont mis en parallèle dans ce texte, et éclairés à la lumière des innovations scientifiques et technologiques. La détermination des Français, peu expérimentés, à prendre des risques substantiels contraste avec le conservatisme prudent de restaurateurs italiens. Un accent particulier sera mis sur la participation de Palmaroli dans le détachement et la restauration de la célèbre Déposition de Daniele da Volterra.The restoration of Italian paintings at the Louvre, after their confiscation by Napoleon’s deputies, has received considerable attention; however, the concurrent preoccupation of the French in Rome with the detachment of frescoes has been little studied, even though the desire for Raphael’s art led some to plan the extraction of his Stanze frescoes. In this essay, the parallel practices of the transfer method on Raphael’s altarpieces in Paris and the detachment of frescoes by close followers of Raphael and Michelangelo in Rome will be explored in light of the innovations of the age in science and technology. The willingness of the relatively inexperienced French to take substantial risks will be contrasted with the more cautious conservatism of Italian restorers, and special focus will be placed on Palmaroli’s involvement in the detachment and restoration of Daniele da Volterra’s famous Deposition.

  8. Estimate of the intensities of the radioactive nuclides produced at the super-FRS at the future GSI facility

    Energy Technology Data Exchange (ETDEWEB)

    Ricciardi, M.V.

    2004-11-01

    The principal goal of the new facility is the construction of a worldwide unique and technically innovative accelerator system that will provide an extensive range of particle beams. Proton and antiproton beams will be available and ion beams of all chemical elements up to uranium will be produced with world-record intensities. The main employ of the high-intensity ion beams is the production of energetic beams of short-lived (radioactive) nuclei, in the following referred to as exotic or Rare Isotope Beams (RIBs). RIBs are produced in nuclear reactions experienced by the primary beams of stable particles. We report on the study of the production of radioactive nuclides and of their propagation through the Super-FRS. The study was performed by means of a nuclear-reaction Monte-Carlo code, ABRABLA, opportunely implemented for the above-described purpose. This work offers an overview of the radioactivity production in the Super-FRS area; the latter is the required starting knowledge for the design of the shielding structure. (orig.)

  9. Beam tests of full-size prototypes of silicon detectors for TOF heavy-ions diagnostics in Super-FRS

    Science.gov (United States)

    Eremin, V.; Bezbakh, A.; Eremin, I.; Egorov, N.; Fomichev, A.; Golovkov, M.; Gorshkov, A.; Galkin, A.; Kiselev, O.; Knyazev, A.; Kostyleva, D.; Krupko, S.; Mitina, D.; Slepnev, R.; Sharov, P.; Verbitskaya, E.

    2017-03-01

    The full-size prototypes of large-area silicon detectors for the Time-Of-Flight (TOF) diagnostics of heavy ions were tested with 132Xe (600 MeV/u) beam. The obtained time resolution of the prototypes was about 13 ps, which satisfied the requirements of diagnostics for the Super Fragment Separator (Super-FRS) that is under development at GSI, Darmstadt, Germany. The irradiation effect on the timing properties of silicon detectors was studied with super-fast silicon pad detectors with a rise time of 190 ps. It was shown that the changes in the rise time of the leading edge of the detector current response to 40Ar ions (40.5 MeV/u) were negligible up to the fluence of 2 × 1011 ion/cm2 expected after one year of Super-FRS operation. This result confirms the model of the leading edge current pulse formation via a flow of the polarization current in dense tracks of heavy ions and shows the perspectives for application of silicon detectors for the TOF diagnostics of intensive heavy-ion beams.

  10. The polychrome works “Prayer of Tobias and Sarah” and “The Archangel Raphael reveals himself to Tobi and his son Tobias”, inside the Cathedral of Cosenza: diagnostic investigations and considerations on the conditions of conservation

    Directory of Open Access Journals (Sweden)

    Gianluca Nava

    2008-04-01

    Full Text Available The oil paintings and “Prayer of Tobias and Sarah” and “The Archangel Raphael reveals himself to Tobi and his son Tobias”, executed by Francesco Bruno at the end of the XVIII century on oval Conservation Science in Cultural Heritage 210 shaped canvas, were investigated by integrated physica-chemical and analytical methodologies in order to obtain scientific data capable of elucidating the state of conservation and the painting technique. Optical (OM and electronic (SEM-EDS microscopy, micro-FT-IR spectroscopy, were applied on some microfragments whilst the two whole paintings were analyzed by the non invasive IR reflectografy technique. The reflectography evidenced some pentimenti of author on the canvas “Prayer of Tobias and Sarah”, while invasive analysis made it possible to locate the stratigraphic sequence of each canvas and to characterise the constituent materials.

  11. First beam test of a liquid Cherenkov detector prototype for a future TOF measurements at the Super-FRS

    Science.gov (United States)

    Kuzminchuk-Feuerstein, Natalia; Ferber, Nadine; Rozhkova, Elena; Kaufeld, Ingo; Voss, Bernd

    2017-09-01

    In order to separate and identify fragmentation products with the Super-Fragment Separator (SuperFRS) at FAIR a high resolving power detector system is required for position and Time-Of-Flight (TOF) measurements. The TOF detector is used to measure the velocity of the particles and hence, in conjunction with their momentum or energy, to determine their mass and hence their identity. Aiming to develop a system with a precision down to about 50 ps in time and resistant to a high radiation rate of relativistic heavy ions of up to 107 per spill (at the second focal plane), we have shown a conceptual design for a Cherenkov detector envisioned for the future TOF measurements employing Iodine Naphthalene (C10H7I) as a fluid radiator. The application of a liquid radiator allows the circulation of the active material and therefore to greatly reduce the effects of the degradation of the optical performance expected after exposure to the high ion rates at the Super-FRS. The prototype of a TOF-Cherenkov detector was designed, constructed and its key-properties have been investigated in measurements with heavy ions at CaveC at GSI. These measurements were performed with nickel ions at 300-1500 MeV/u and ion-beam intensities of up to 4 × 106 ions/spill of 8 s. As a first result a maximum detection efficiency of 70% and a timing resolution of 267 ps (σ) was achieved. We report the first attempt of time measurements with a Cherenkov detector based on a liquid radiator. Further optimization is required.

  12. 1 March 2012 - British University of Oxford Head of the Mathematical, Physical & Life Sciences Division A. N. Halliday FRS signing the guest book with Director for Research and Scientific Computing S. Bertolucci.

    CERN Multimedia

    Jean-Claude Gadmer

    2012-01-01

    1 March 2012 - British University of Oxford Head of the Mathematical, Physical & Life Sciences Division A. N. Halliday FRS signing the guest book with Director for Research and Scientific Computing S. Bertolucci.

  13. Novel flame retardants (N-FRs), polybrominated diphenyl ethers (PBDEs) and dioxin-like polychlorinated biphenyls (DL-PCBs) in fish, penguin, and skua from King George Island, Antarctica.

    Science.gov (United States)

    Wolschke, Hendrik; Meng, Xiang-Zhou; Xie, Zhiyong; Ebinghaus, Ralf; Cai, Minghong

    2015-07-15

    Persistent organic pollutants (POPs), including polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs), are frequently detected in biota from Antarctica, whereas no data are available for their replacements, such as novel flame retardants (N-FRs). This study presented the occurrence of several N-FRs, PBDEs, and PCBs in tissue samples of an Antarctic rock cod (Trematomus bernacchii), a young gentoo penguin (Pygoscelis papua), and a brown skua (Stercorarius antarcticus) collected from King George Island. The total concentrations of N-FRs (ΣN-FRs; mean: 931 pg/g dry weight (dw)) were comparable to PBDEs (Σ8PBDEs; 681 pg/gdw), which were much lower than PCBs (ΣDL-PCBs; 12,800 pg/gdw). Overall, skua contained two to three orders of magnitude higher contamination than penguin and fish. In the future, more attention should be focused on the fate of N-FRs in Antarctica, where usages have increased since PBDEs were banned. To our knowledge, this is the first report of N-FRs in biota from Antarctica. Copyright © 2015. Published by Elsevier Ltd.

  14. Investigations of the MCP Detector of a Time-Of-Flight Detector for IMS at the FRS-ESR

    Energy Technology Data Exchange (ETDEWEB)

    Hornung, Christine; Diwisch, Marcel; Kuzminchuk-Feuerstein, Natalia [Justus Liebig Universitaet Giessen (Germany); Geissel, Hans; Plass, Wolfgang; Scheidenberger, Christoph [Justus Liebig Universitaet Giessen (Germany); GSI, Darmstadt (Germany)

    2013-07-01

    The Isochronous Mass Spectrometry at the FRS-ESR facility at GSI can be used to perform high-precision mass measurements of exotic nuclei. The mass values are obtained from measuring the revolution time of the ions in the storage ring with a time-of-flight detector. The ions pass a thin carbon foil in the detector and release secondary electrons. These electrons are guided by electric and magnetic fields to two MCP detectors. Their number is amplified by micro channel plates and the resulting current is detected by an anode. In order to achieve an accurate time signal, the timing performance of the MCP detector is very important. The timing performance and the signal shape of the detector setup has been improved by including a new anode design. At the same time, the detector performance dependence on the magnetic field and the electron velocity inside of the MCP-detector was tested. The new detector design and the test results are presented.

  15. Experimental and numerical analysis of the flow in contraction nozzles of the liquid metal targets for Super-FRS

    Energy Technology Data Exchange (ETDEWEB)

    Stoppel, L.; Stieglitz, R.; Daubner, M.; Fellmoser, F. [Forschungszentrum Karlsruhe GmbH, Karlsruhe (DE). Inst. fuer Kern- und Energietechnik (IKET); Gordeev, S. [Forschungszentrum Karlsruhe GmbH, Karlsruhe (DE). Inst. fuer Reaktorsicherheit (IRS)

    2008-07-01

    The trend towards higher beam intensities in accelerator applications enforces the development of free surface targets in order to ensure a safe heat removal of the deposited beam energy. In the heavy-ion synchrotron facility FAIR of GSI a wide range of particle energies will be used for the production of fragments by projectile fragmentation at the fragment separator Super-FRS. For the highest power densities envisaged, a windowless vertical liquid-Li-jet-target with a rectangular shape is considered. In order to capture the whole beam dimensions within the lithium jet the variation of the jet depth over a height of 50 mm in vertical direction should not exceed more than {+-} 1%. This demands nozzle design of the target ensuring a uniform velocity profile at the nozzle exit at a simultaneously low turbulence intensity. The nozzle shape influences significantly the stability of the jet leaving the bounded duct flow. Here, mainly the turbulence distribution within the boundary layer is of importance. This extremely crucial boundary condition at the nozzle exit is a prerequisite for a reliable target operation and thus the subject of this combined experimental and numerical study. In a previous study the main parameters influencing the jet flow were elaborated, while this investigation focuses on optical velocity measurements within the boundary layer at prototypical velocities. The experimental data are compared to numerical simulations in order to validate limits of commonly used turbulence models for this type of application. (orig.)

  16. Mass measurement of cooled neutron-deficient bismuth projectile fragments with time-resolved Schottky mass spectrometry at the FRS-ESR facility

    Energy Technology Data Exchange (ETDEWEB)

    Litvinov, Yu.A.; Geissel, H. [Giessen Univ. (Germany); Radon, T. [Gesellschaft fuer Schwerionenforschung mbH, Darmstadt (DE)] [and others

    2005-06-01

    Masses of 582 neutron-deficient nuclides (30{<=}Z{<=}85) were measured with time-resolved Schottky mass spectrometry at the FRS-ESR facility at GSI, 117 were used for calibration. The masses of 71 nuclides were obtained for the first time. A typical mass accuracy of 30 {mu}u was achieved. These data have entered the latest atomic mass evaluation. The mass determination of about 140 additional nuclides was possible via known energies (Q-values) of {alpha}-, {beta}-, or proton decays. The obtained results are compared with the results of other measurements. (orig.)

  17. FRS EZ Query

    Science.gov (United States)

    This page is the starting point for EZ Query. This page describes how to select key data elements from EPA's Facility Information Database and Geospatial Reference Database to build a tabular report or a Comma Separated Value (CSV) files for downloading.

  18. 2112-IJBCS-Article-Raphael Okonji

    African Journals Online (AJOL)

    hp

    In the present study, the hot and cold aqueous extracts of Digitaria exilis and Pentadiplandra brazzeana (Baill) as well as the ethanolic extract of Monodora myristica were screened for their anti diabetic activity via inhibition of α-amylase. The root of Pentadiplandra brazzeana Baill and the grains of Acha (Digitaria exilis) ...

  19. 354-IJBCS-Article-Okonji E Raphael

    African Journals Online (AJOL)

    RHUMSIKI

    Rhodanese (cyanide: thiosulphate sulphur transferase; EC.2.8.1.1) was isolated from cytosolic fraction of tortoise liver using ammonium sulphate fractionation, ion exchange chromatography and gel filtration from the liver of tortoise. The enzyme had a specific activity of 14.43 RU per milligram of protein. The Km values for ...

  20. 354-IJBCS-Article-Okonji E Raphael

    African Journals Online (AJOL)

    RHUMSIKI

    enzyme originally found in the mitochondrion has now been reported to also be located in the cytosol and other organelles (Nagahara et al., 1999; Agboola and Okonji, 2004;. Akinsiku et al., 2009). Its presence in the liver tissues of different animals has been demonstrated (Blumenthal and Heinrikson,. 1971; Jarabak and ...

  1. 2112-IJBCS-Article-Raphael Okonji

    African Journals Online (AJOL)

    hp

    caries and periodontal diseases (Sales et al.,. 2012). Diabetes Mellitus is a common metabolic and a multi-system disorder comprising of metabolic and vascular ... degradation of dietary starch by glucosidases such as α-amylase and α -glucosidase (Rang et al., 2003). The use of herbs in the management of diabetes is not ...

  2. Walter Frank Raphael Weldon (1860–1906)

    Indian Academy of Sciences (India)

    the first naturally gifted teacher who had taught him (incidentally, Weldon himself was later revered as an amazingly .... variations in parents and offspring, among different life-stages, and, finally, the correlations between ... wife that scientific disagreements had marred his warm personal friendship with Weldon. Be- fore too ...

  3. β-decay and β-delayed Neutron Emission Measurements at GSI-FRS Beyond N=126, for r-process Nucleosynthesis

    Energy Technology Data Exchange (ETDEWEB)

    Caballero-Folch, R., E-mail: roger.caballero@upc.edu [Deptartament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya, E-08028 Barcelona (Spain); Domingo-Pardo, C. [Institut de Física Corpuscular, CSIC-Universitat de València, E-46071 València (Spain); Cortès, G. [Deptartament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya, E-08028 Barcelona (Spain); Taín, J.L.; Agramunt, J. [Institut de Física Corpuscular, CSIC-Universitat de València, E-46071 València (Spain); Algora, A. [Institut de Física Corpuscular, CSIC-Universitat de València, E-46071 València (Spain); Institute of Nuclear Research of Hungarian Academy of Sciences, Debrecen (Hungary); Ameil, F. [GSI Helmholtzzentrum für Schwerionenforschung, D-64291, Darmstadt (Germany); Ayyad, Y.; Benlliure, J. [Universidade de Santiago de Compostela, E-15782, Santiago de Compostela (Spain); Bowry, M. [Department of Physics, University of Surrey, Guildford GU2 7XH (United Kingdom); Calviño, F. [Deptartament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya, E-08028 Barcelona (Spain); Cano-Ott, D. [Centro de Investigaciones energéticas Medioambientales y Tecnológicas, Madrid (Spain); Davinson, T. [School of Physics and Astronomy, University of Edinburgh, Edinburgh EH9 3JZ United Kingdom (United Kingdom); and others

    2014-06-15

    New measurements of very exotic nuclei in the neutron-rich region beyond N=126 have been performed at the GSI facility with the fragment separator (FRS). The aim of the experiment is to determine half-lives and β-delayed neutron emission branching ratios of isotopes of Hg, Tl and Pb in this region. This contribution summarizes final counting statistics for identification and for implantation, as well as the present status of the data analysis of the half-lives. In summary, isotopes of Pt, Au, Hg, Tl, Pb, Bi, Po, At, Rn and Fr were clearly identified and several of them ({sup 208-211}Hg, {sup 211-215}Tl, {sup 214-218}Pb) were implanted with enough statistics to determine their half-lives. About half of them are expected to be neutron emitters, in such cases it will become possible to obtain the neutron emission probabilities, Pn.

  4. $\\beta$-decay and $\\beta$-delayed Neutron Emission Measurements at GSI-FRS Beyond N=126, for r-process Nucleosynthesis

    CERN Document Server

    Caballero-Folch, R; Cortès, G; Taín, J L; Agramunt, J; Algora, A; Ameil, F; Ayyad, Y; Benlliure, J; Bowry, M; Calviño, F; Cano-Ott, D; Davinson, T; Dillmann, I; Estrade, A; Evdokimov, A; Faestermann, T; Farinon, F; Galaviz, D; García-Ríos, A; Geissel, H; Gelletly, W; Gernhäuser, R; Gómez-Hornillos, M B; Guerrero, C; Heil, M; Hinke, C; Knöbel, R; Kojouharov, I; Kurcewicz, J; Kurz, N; Litvinov, Y; Maier, L; Marganiec, J; Marta, M; Martínez, T; Montes, F; Mukha, I; Napoli, D R; Nociforo, C; Paradela, C; Pietri, S; Podolyák, Zs; Prochazka, A; Rice, S; Riego, A; Rubio, B; Schaffner, H; Scheidenberger, C; Smith, K; Sokol, E; Steiger, K; Sun, B; Takechi, M; Testov, D; Weick, H; Wilson, E; Winfield, J S; Wood, R; Woods, P J; Yeremin, A

    2014-01-01

    New measurements of very exotic nuclei in the neutron-rich region beyond N=126 have been performed at the GSI facility with the fragment separator (FRS). The aim of the experiment is to determine half-lives and beta-delayed neutron emission branching ratios of isotopes of Hg, Tl and Pb in this region. This contribution summarizes final counting statistics for identification and for implantation, as well as the present status of the data analysis of the half-lives. In summary, isotopes of Pt, Au, Hg, Ti, Pb, Bi, Po, At, Rn and Fr were clearly identified and several of them (Hg208-211, Tl211-215, Pb214-218) were implanted with enough statistics to determine their half-lives. About half of them are expected to be neutron emitters, in such cases it will become possible to obtain the neutron emission probabilities, P-n.

  5. Online commissioning of a multiple-reflection time-of-flight mass spectrometer (MR-ToF-MS) at the FRS ion catcher

    Energy Technology Data Exchange (ETDEWEB)

    Ebert, Jens; Jesch, Christian; Lang, Johannes; Reiter, Moritz P. [JLU Giessen (Germany); Dickel, Timo; Plass, Wolfgang R.; Geissel, Hans; Haettner, Emma; Knoebel, Ronja; Scheidenberger, Christoph [JLU Giessen (Germany); GSI, Darmstadt (Germany); Ayet, Samuel; Estrade, Alfredo; Farinon, Fabio; Kurcewicz, Jan; Nociforo, Chiara; Pietri, Stephane; Prochazka, Andrej; Purushothaman, Sivaji; Takechi, Maya; Winfield, John; Weick, Helmut [GSI, Darmstadt (Germany); Dendooven, Peter; Kalantar-Nayestanaki, Nasser; Ranjan, Manisha [KVI, University of Groningen (Netherlands); Moore, Iain; Rinta-Antila, Sami [University of Jyvaeskylae (Finland); Yavor, Mikhail I. [Russian Academy of Sciences, St. Petersburg (Russian Federation)

    2012-07-01

    A MR-TOF-MS covers a wide field of applications, from ultra high-resolution and broad band mass measurements to isobar separation. To enhance the performance of our MR-TOF-MS several important improvements have been implemented. Such as a new detector system, that opens further application areas like decay-spectroscopy of isobarically clean beams. Online commissioning of the MR-TOF-MS has been performed using radioactive nuclei at the FRS Ion Catcher. The ions were stopped in a novel cryogenic stopping cell and the MR-TOF-MS was used for performance investigation of the stopping cell. Results of the improvements and the online measurements will be presented as well as future perspectives.

  6. Discovery and cross-section measurement of neutron-rich isotopes in the element range from neodymium to platinum with the FRS

    Energy Technology Data Exchange (ETDEWEB)

    Kurcewicz, J., E-mail: j.kurcewicz@gsi.de [GSI Helmholtzzentrum fuer Schwerionenforschung, 64291 Darmstadt (Germany); Farinon, F.; Geissel, H. [GSI Helmholtzzentrum fuer Schwerionenforschung, 64291 Darmstadt (Germany); Justus-Liebig-Universitaet Giessen, 35392 Giessen (Germany); Pietri, S.; Nociforo, C. [GSI Helmholtzzentrum fuer Schwerionenforschung, 64291 Darmstadt (Germany); Prochazka, A. [GSI Helmholtzzentrum fuer Schwerionenforschung, 64291 Darmstadt (Germany); Justus-Liebig-Universitaet Giessen, 35392 Giessen (Germany); Weick, H.; Winfield, J.S. [GSI Helmholtzzentrum fuer Schwerionenforschung, 64291 Darmstadt (Germany); Estrade, A. [GSI Helmholtzzentrum fuer Schwerionenforschung, 64291 Darmstadt (Germany); Astronomy and Physics Department, Saint Mary' s University, Halifax, Nova Scotia B3H 3C3 (Canada); Allegro, P.R.P. [Institute of Physics, Universidade de Sao Paulo, CEP 05508-090 Cidade Universitaria, Sao Paulo (Brazil); Bail, A.; Belier, G. [CEA DAM DiF, 91290 Arpajon Cedex (France); Benlliure, J. [Universidad de Santiago de Compostela, E-15706 Santiago de Compostella (Spain); Benzoni, G. [INFN sezione di Milano, I-20133 Milano (Italy); Bunce, M.; Bowry, M. [Department of Physics, University of Surrey, Guildford, Surrey, GU2 7XH (United Kingdom); Caballero-Folch, R. [Universitat Politecnica de Catalunya, 08034 Barcelona (Spain); and others

    2012-10-31

    Using the high-resolution performance of the fragment separator FRS at GSI we have discovered 60 new neutron-rich isotopes in the atomic number range of 60 Less-Than-Or-Slanted-Equal-To Z Less-Than-Or-Slanted-Equal-To 78. The new isotopes were unambiguously identified in reactions with a {sup 238}U beam impinging on a Be target at 1 GeV/nucleon. The production cross-section for the new isotopes have been measured down to the pico-barn level and compared with predictions of different model calculations. For elements above hafnium fragmentation is the dominant reaction mechanism which creates the new isotopes, whereas fission plays a dominant role for the production of the new isotopes up to thulium.

  7. Discovery and cross-section measurement of neutron-rich isotopes in the element range from neodymium to platinum with the FRS

    Science.gov (United States)

    Kurcewicz, J.; Farinon, F.; Geissel, H.; Pietri, S.; Nociforo, C.; Prochazka, A.; Weick, H.; Winfield, J. S.; Estradé, A.; Allegro, P. R. P.; Bail, A.; Bélier, G.; Benlliure, J.; Benzoni, G.; Bunce, M.; Bowry, M.; Caballero-Folch, R.; Dillmann, I.; Evdokimov, A.; Gerl, J.; Gottardo, A.; Gregor, E.; Janik, R.; Kelić-Heil, A.; Knöbel, R.; Kubo, T.; Litvinov, Yu. A.; Merchan, E.; Mukha, I.; Naqvi, F.; Pfützner, M.; Pomorski, M.; Podolyák, Zs.; Regan, P. H.; Riese, B.; Ricciardi, M. V.; Scheidenberger, C.; Sitar, B.; Spiller, P.; Stadlmann, J.; Strmen, P.; Sun, B.; Szarka, I.; Taïeb, J.; Terashima, S.; Valiente-Dobón, J. J.; Winkler, M.; Woods, Ph.

    2012-10-01

    Using the high-resolution performance of the fragment separator FRS at GSI we have discovered 60 new neutron-rich isotopes in the atomic number range of 60 ⩽ Z ⩽ 78. The new isotopes were unambiguously identified in reactions with a 238U beam impinging on a Be target at 1 GeV/nucleon. The production cross-section for the new isotopes have been measured down to the pico-barn level and compared with predictions of different model calculations. For elements above hafnium fragmentation is the dominant reaction mechanism which creates the new isotopes, whereas fission plays a dominant role for the production of the new isotopes up to thulium.

  8. β-decay and β-delayed Neutron Emission Measurements at GSI-FRS Beyond N = 126, for r-process Nucleosynthesis

    Science.gov (United States)

    Caballero-Folch, R.; Domingo-Pardo, C.; Cortès, G.; Taín, J. L.; Agramunt, J.; Algora, A.; Ameil, F.; Ayyad, Y.; Benlliure, J.; Bowry, M.; Calviño, F.; Cano-Ott, D.; Davinson, T.; Dillmann, I.; Estrade, A.; Evdokimov, A.; Faestermann, T.; Farinon, F.; Galaviz, D.; García-Ríos, A.; Geissel, H.; Gelletly, W.; Gernhäuser, R.; Gómez-Hornillos, M. B.; Guerrero, C.; Heil, M.; Hinke, C.; Knöbel, R.; Kojouharov, I.; Kurcewicz, J.; Kurz, N.; Litvinov, Y.; Maier, L.; Marganiec, J.; Marta, M.; Martínez, T.; Montes, F.; Mukha, I.; Napoli, D. R.; Nociforo, C.; Paradela, C.; Pietri, S.; Podolyák, Zs.; Prochazka, A.; Rice, S.; Riego, A.; Rubio, B.; Schaffner, H.; Scheidenberger, C.; Smith, K.; Sokol, E.; Steiger, K.; Sun, B.; Takechi, M.; Testov, D.; Weick, H.; Wilson, E.; Winfield, J. S.; Wood, R.; Woods, P. J.; Yeremin, A.

    2014-06-01

    New measurements of very exotic nuclei in the neutron-rich region beyond N=126 have been performed at the GSI facility with the fragment separator (FRS). The aim of the experiment is to determine half-lives and β-delayed neutron emission branching ratios of isotopes of Hg, Tl and Pb in this region. This contribution summarizes final counting statistics for identification and for implantation, as well as the present status of the data analysis of the half-lives. In summary, isotopes of Pt, Au, Hg, Tl, Pb, Bi, Po, At, Rn and Fr were clearly identified and several of them (208-211Hg, 211-215Tl, 214-218Pb) were implanted with enough statistics to determine their half-lives. About half of them are expected to be neutron emitters, in such cases it will become possible to obtain the neutron emission probabilities, Pn.

  9. Efficiency and rate capability studies of the time-of-flight detector for isochronous mass measurements of stored short-lived nuclei with the FRS-ESR facility

    Science.gov (United States)

    Kuzminchuk-Feuerstein, Natalia; Fabian, Benjamin; Diwisch, Marcel; Plaß, Wolfgang R.; Geissel, Hans; Ayet San Andrés, Samuel; Dickel, Timo; Knöbel, Ronja; Scheidenberger, Christoph; Sun, Baohua; Weick, Helmut

    2016-06-01

    A time-of-flight (TOF) detector is used for Isochronous Mass Spectrometry (IMS) with the projectile fragment separator FRS and the heavy-ion storage ring ESR. Exotic nuclei are spatially separated in flight with the FRS at about 70% of the speed of light and are injected into the ESR. The revolution times of the stored ions circulating in the ESR are measured with a thin transmission foil detector. When the ions penetrate the thin detector foil, secondary electrons (SEs) are emitted from the surface and provide the timing information in combination with microchannel plate (MCP) detectors. The isochronous transport of the SEs is performed by perpendicular superimposed electric and magnetic fields. The detection efficiency and the rate capability of the TOF detector have been studied in simulations and experiments. As a result the performance of the TOF detector has been improved substantially: (i) The SE collection efficiency was doubled by use of an optimized set of electric and magnetic field values; now SEs from almost the full area of the foil are transmitted to the MCP detectors. (ii) The rate capability of the TOF detector was improved by a factor of four by the use of MCPs with 5 μm pore size. (iii) With these MCPs and a carbon foil with a reduced thickness of 10 μg/cm2 the number of recorded revolutions in the ESR has been increased by nearly a factor of 10. The number of recorded revolutions determine the precision of the IMS experiments. Heavy-ion measurements were performed with neon ions at 322 MeV/u and uranium fission fragments at about 370 MeV/u. In addition, measurements with an alpha source were performed in the laboratory with a duplicate of the TOF detector.

  10. Efficiency and rate capability studies of the time-of-flight detector for isochronous mass measurements of stored short-lived nuclei with the FRS-ESR facility

    Energy Technology Data Exchange (ETDEWEB)

    Kuzminchuk-Feuerstein, Natalia; Fabian, Benjamin [II. Physikalisches Institut, Justus-Liebig-Universität, 35392 Gießen (Germany); GSI Helmholtzzentrum für Schwerionenforschung, 64291 Darmstadt (Germany); Diwisch, Marcel [II. Physikalisches Institut, Justus-Liebig-Universität, 35392 Gießen (Germany); Plaß, Wolfgang R., E-mail: Wolfgang.R.Plass@exp2.physik.uni-giessen.de [II. Physikalisches Institut, Justus-Liebig-Universität, 35392 Gießen (Germany); GSI Helmholtzzentrum für Schwerionenforschung, 64291 Darmstadt (Germany); Geissel, Hans; Ayet San Andrés, Samuel; Dickel, Timo; Knöbel, Ronja; Scheidenberger, Christoph [II. Physikalisches Institut, Justus-Liebig-Universität, 35392 Gießen (Germany); GSI Helmholtzzentrum für Schwerionenforschung, 64291 Darmstadt (Germany); Sun, Baohua [II. Physikalisches Institut, Justus-Liebig-Universität, 35392 Gießen (Germany); Weick, Helmut [GSI Helmholtzzentrum für Schwerionenforschung, 64291 Darmstadt (Germany)

    2016-06-11

    A time-of-flight (TOF) detector is used for Isochronous Mass Spectrometry (IMS) with the projectile fragment separator FRS and the heavy-ion storage ring ESR. Exotic nuclei are spatially separated in flight with the FRS at about 70% of the speed of light and are injected into the ESR. The revolution times of the stored ions circulating in the ESR are measured with a thin transmission foil detector. When the ions penetrate the thin detector foil, secondary electrons (SEs) are emitted from the surface and provide the timing information in combination with microchannel plate (MCP) detectors. The isochronous transport of the SEs is performed by perpendicular superimposed electric and magnetic fields. The detection efficiency and the rate capability of the TOF detector have been studied in simulations and experiments. As a result the performance of the TOF detector has been improved substantially: (i) The SE collection efficiency was doubled by use of an optimized set of electric and magnetic field values; now SEs from almost the full area of the foil are transmitted to the MCP detectors. (ii) The rate capability of the TOF detector was improved by a factor of four by the use of MCPs with 5 μm pore size. (iii) With these MCPs and a carbon foil with a reduced thickness of 10 μg/cm{sup 2} the number of recorded revolutions in the ESR has been increased by nearly a factor of 10. The number of recorded revolutions determine the precision of the IMS experiments. Heavy-ion measurements were performed with neon ions at 322 MeV/u and uranium fission fragments at about 370 MeV/u. In addition, measurements with an alpha source were performed in the laboratory with a duplicate of the TOF detector.

  11. Unambiguous identification and investigation of uranium projectile fragments. Discovery of 63 new neutron-rich isotopes in the element range 61≤Z≤78 at the FRS

    Energy Technology Data Exchange (ETDEWEB)

    Farinon, Fabio

    2011-10-15

    The research of exotic, short-lived nuclei is a main contribution of modern nuclear physics to improve the knowledge of the strong interaction and to understand the synthesis of elements in stellar media. Nature is still ahead of the laboratories since in the astrophysical r-process very neutron-rich nuclides are continuously created which we just barely reach or which still have to be discovered. For this challenge new powerful accelerators and experimental tools have been developed to expand the frontiers of discovered nuclides. Besides a high intensity primary beam efficient and very sensitive in-flight separators are needed to access new nuclides in this field. To exploit the full discovery potential also the applied particle detectors and especially the unambiguous identification have to be steadily improved and extended in the experiments. In the presented work Uranium projectile fragmentation and fission have been used to discover new neutron-rich nuclides in the Z-range above 60 at the FRS. In this region of heavy nuclides most radioactive beam facilities have clearly strong limitations.

  12. Foreword: Sir John Pendry FRS Sir John Pendry FRS

    Science.gov (United States)

    Inglesfield, John; Echenique, Pedro

    2008-07-01

    John Pendry John Inglesfield and Pedro Echenique write: John Pendry's 65th birthday is on 4 July 2008, and this issue of the Journal of Physics: Condensed Matter is dedicated to him, with articles by friends, colleagues, and former students. By any standards, John Pendry is a great scientist, who has made—and continues to make—an enormous contribution to physics; the wide range of his interests is reflected in the scope of these articles. Not many scientists can establish a completely new and unexpected area of research, but this has been John's achievement in the last few years in the field of metamaterials, materials whose electromagnetic properties depend on their structure rather than the materials of which the structure is built. In this way, structures with effectively negative electrical permittivity and negative magnetic permeability can be constructed, demonstrating negative refraction; through metamaterials scientists now have access to properties not found in nature, and never previously explored experimentally. Never a week goes by without a potential new application of metamaterials, whether it is perfect lensing, or the cloak of invisibility. This has certainly led to tremendous visibility for John himself, with guest lectures all over the world, and radio and television appearances. John Pendry's first paper was published exactly 40 years ago, 'Analytic properties of pseudopotentials' [1], and since then he has published 310 articles at the latest count. But this first paper already reflected something of the way John works. His PhD project, with Volker Heine at the Cavendish Laboratory, was to interpret the scattering of low energy electrons from surfaces, the technique of LEED which was to become the method of choice for determining surface structure. Although the energy of the electrons in LEED is relatively low—say 50 eV—it is much higher than the energy of the conduction electrons, for which pseudopotentials had been devised, and John realised that he should explore the properties of pseudopotentials in depth. This had never been done before, and the result was a paper of typical originality. The story of how John explored truly original aspects of physics, right from the start of his research career, is given by Volker Heine (in his own inimitable style), at the end of this short biography. Of course the result of John's PhD research was his development of the entire methodology for computing and interpreting LEED intensities, and their relationship to surface atomic structure. With experiments performed by Stig Andersson in Gothenburg, John's calculations led to the first ever surface structure determination, of Na adsorbed in a c(2 x 2) structure on Ni(001) [2]. His 1974 book, 'Low Energy Electron Diffraction' [3], remains a classic, and not only for LEED theorists—there is plenty of other surface science here to get one's teeth into. John extended the theory of LEED in the 1980s with the introduction of several new theoretical techniques and concepts. The Pendry R-factor [4] enabled surface structure determination to be largely automated, and quantified agreement between LEED theory and experiment. Tensor-LEED was developed by John, together with his PhD student Philip Rous [5], as an accurate approximation for calculating the LEED spectra of complex surface structures, enabling structures of hitherto impossible complexity to be determined. The methods of DLEED—both the experimental technique and its theoretical interpretation—were developed with Saldin, Van Hove and the Erlangen group of Heinz and Müller [6, 7]; this is a technique for interpreting electron scattering from atoms randomly adsorbed on surfaces, hence determining their bonding to neighbouring atoms. LEED experiments and calculations continue to this day, of course, with John's contribution remaining fundamental. Articles in this issue by John's former PhD student Michel Van Hove, his one-time post-doc Dilano Saldin, and his long-standing collaborator Klaus Heinz, illustrate the power of LEED in determining surface structure. And everywhere in the surface science literature you will see the Pendry R-factor quoted, as a measure of the accuracy of the structure determination. The contribution which theory and computation can make to the interpretation of electron spectroscopies has been an underlying theme in John's work over many years, and as in the case of LEED he has developed the computer programs to make the interpretation possible. After finishing his PhD in 1969, and during the period of a research fellowship at Downing College, Cambridge, John spent the year 1972-3 at Bell Laboratories in Murray Hill, New Jersey; it was there that he started collaborating with Patrick Lee on the interpretation of extended x-ray absorption fine structure (EXAFS) [8], oscillations seen above the absorption edge when x-rays excite core electrons of atoms in a molecular or solid state environment. This was the first quantitative theory of the effect, and led to the use of EXAFS in determining atomic structure in systems, such as glasses, where x-ray diffraction is less useful. Since then, EXAFS and its derivative techniques such as NEXAFS (which explores the structure immediately above the absorption edge, particularly sensitive to chemical bonding), and SEXAFS (EXAFS at surfaces) have become standard techniques in the armoury of structure determination methods at every synchrotron radiation laboratory. And it was to the Daresbury Laboratory in Cheshire, with its synchrotron radiation facility, that John moved in 1975, from Cambridge, as Head of the Theory Group. This was an inspired appointment on the part of the then Science and Engineering Research Council, as it led to unrivalled theoretical support for the electron spectroscopists using the SRS facility. For John it was a move back to the North of England, the area from which he came and where he had been to school. In Daresbury he published his theory of angle-resolved photoemission [9], which remains the standard model in the field. These methods have enabled the band structure of electrons in solids and at surfaces to be determined to unprecedented accuracy, on the basis of photoemission experiments. But photoemission involves the occupied electronic states—what about the unoccupied states? These are just as important, certainly from the point of view of understanding the band structure and the many-body interaction with other electrons. In 1980 John proposed the technique of inverse photoemission, in which an electron emits light as it decays into the unoccupied states in the vicinity of the surface [10]. The viability of this technique was demonstrated soon afterwards, and it is now widely used for probing unoccupied electron states. It was natural that John should explore the nature of electronic states at surfaces, and with Steve Gurman and later Pedro Echenique he developed criteria for the existence of the localised surface states, so important in determining surface properties and readily detectable using photoemission and inverse photoemission [11]. Their computational techniques were based on those used in the LEED and photoemission programs—the semi-infinite solid is split into atomic layers, the scattering properties of each layer are calculated, and then these are combined together to give the scattering of the solid with a surface. Such techniques are still immensely useful, and Simon Crampin has developed them further to calculate electronic states at surfaces with atomic islands, for example. This work began when John was still at Cambridge, but it was after his move to Daresbury that perhaps his most important work on surface states was produced—the demonstration of the possibility of resolving the image-potential-induced surface states on metal surfaces, with Echenique [12]. These states are caused by the image potential trapping an electron, which cannot penetrate into the bulk if its energy lies in a band-gap; the image states form a Rydberg series, and as their energy is just below the vacuum level, they are normally unoccupied. This makes inverse photoemission the ideal technique for observing them. Recent developments on two-photon photoemission, energy- and time-resolved, have produced a wealth of experimental information on these states. Since their prediction and observation, image states have become a playground for theoretical and experimental studies of many-electron effects at surfaces. It is remarkable how John Pendry maintained his position as the leading theoretical surface physicist in the UK (and possibly the world) at the same time that he developed new areas of research. In 1981 John moved to Imperial College as Professor of Theoretical Solid State Physics and Head of the Condensed Matter Theory Group, and soon after began to study the behaviour of electrons in disordered systems, a field in which he collaborated with his colleague Angus MacKinnon. John applied group theoretical methods to study the transport of electrons in disordered media, and obtained for the first time a complete solution of the general scattering problem in one dimension [13], deriving advanced techniques for studying higher dimensions [14]. A key result was the prediction that in all dimensions, the channels for transport (distinct ways in which an electron can propagate through the system) are either open (that is, essentially transparent) or closed (opaque) in the limit of large systems [15]. These notions are relevant to such topical research as the conductivity of bio-molecules. In this novel approach to transport, John was helped by his wife Pat, who is a mathematician by training, with a thesis on group representation theory—John benefited not only from Pat's expertise, but also from her library on group theory, which was far better than that of most universities! (John and Pat wrote a joint paper shortly after they met in Cambridge, on scattering methods—a recurring theme in John's research [16].) What drove John to develop this new area of research, when the work on LEED and tensor-LEED was progressing so successfully? The answer is that he has always made a conscious effort to work on completely new topics, every ten years or so. The question was what next? We remember John remarking about 20 years ago that the propagation of light in artificial periodic systems would be important in the future, and it turned out that the layer techniques he had developed for electronic structure could be adapted to electromagnetic waves (not so straightforward because of the vectorial nature of the electromagnetic field). As a result, and because of his appreciation of the importance of this field, John was working in photonics right from the start, and in 1994 he published his first papers on photonic band structures; his techniques enabled the interaction of light with metallic systems to be calculated, unlike the existing, poorly converging, plane wave methods. The titles of his early photonics papers show the originality of his work, and perhaps already indicate where it would eventually lead—'Refraction and geometry in Maxwell's equations'[17], 'Absolute three-dimensional photonic band gap in the infrared regime in woven structures' [18], 'Transmission resonances on metallic gratings with very narrow slits' [19], and many more. John went much further than most other researchers in the field, for example exploring the consequences of the near-field electromagnetic radiation, leading amongst other effects to friction between separated resistive plates, which could be associated with Van der Waal's forces [20]. And early on, he had invented the concept of metamaterials, devising a metallic mesostructure consisting of a three-dimensional array of wires with an extremely low plasmon frequency [21, 22]. Where it led to was the brilliant work on metamaterials which would show negative refraction [23, 24], the concept of the perfect lens [25], ways of exploiting the near field for imaging purposes [26], methods of controlling electromagnetic fields and 'cloaks of invisibility [27], and much more. His physical insight, as well as his mathematical virtuosity, was demonstrated early on in the story of metamaterials by the famous split-ring structure, with negative magnetic permeability as well as negative permittivity, and the way that John could solve Maxwell's equations for this system to give an effective epsilon and μ [23]. The split-ring resonator has been adopted in many laboratories as the starting point for their metamaterial designs. The work on the perfect lens sparked storms of enthusiasm and controversy in equal measure when it was first published in 2000, in the Physical Review Letter 'Negative refraction makes a perfect lens' [25]. Many eminent scientists demonstrated that the perfect lens, unlimited by conventional resolution criteria, was impossible, but of course it wasn't (we knew he was right!), and John's experimental colleagues have subsequently demonstrated the lensing effect. John's paper in 2000 has already been cited more than 1300 times, and was named letter-of-the-year: it can safely be said that the concept of the perfect lens has revolutionised nanoscale optics. His recent work with collaborators at Duke has shown that it is possible to design a 'cloak' that screens objects from electromagnetic fields; this resolved a long-standing mathematical challenge, questioning whether a region of space could be completely screened in this way [27]. Needless to say, this concept of a cloak of invisibility, which has been realised experimentally [28], has attracted great media interest, as well as numerous emails from schoolchildren. John has always made a full contribution to wider scientific life, and during this latest, immensely productive period he has been Dean of the Royal College of Science (1993-1996), Head of Department at Imperial College (1998-2001), and subsequently Principal of the Faculty of Physical Sciences (2001- 2002). He has taken on the chairmanship of the Physics Sub-Panel of the 2008 UK Research Assessment Exercise, a huge task which he began in 2005. Elected a Fellow of the Royal Society in 1984, he has been Member of Council from 1992-1994, and Editor of the Royal Society Proceedings A from 1996-2002. For the Institute of Physics, since 2007 he has been Member of Council, Chairman of Institute of Physics Publishing and Vice-President for Publishing. He has received honours and awards, recognising his contributions, culminating in his knighthood for services to science in 2004, and the Royal Medal of the Royal Society in 2006. John Pendry has worked with many research students, post-docs, and leading theoreticians and experimentalists, and has always been thoughtful and generous in his interactions with others. He is a very loyal person, loyal to friends, colleagues, his old college—it gave him great pleasure to be awarded an Honorary Fellowship at Downing College in 2005. Beyond science there is that necessary hinterland, particularly his love and knowledge of music, for John is a fine pianist. We also think of his enjoyment of gardening, photography, the countryside, and natural history: hobbies shared with Pat. John relishes gadgets—the latest GPS or camera lens—perhaps his interest in photography kindled his interest in imaging? This is our friend John Pendry, whom we have had the privilege of knowing for 40 years—may he enjoy many more years of activity, research and the rest, in the years beyond his 65th birthday! Volker Heine1 writes: What I can contribute is a bit of history about John as a research student. After his Part II in Natural Sciences, he went on to do a one-year graduate diploma in advanced theoretical physics, called Part III of the Mathematics Tripos. I was away in Chicago on my first sabbatical leave, and Leo Falicov was spending a year in Cambridge holding the fort. So I asked him was this chap (JBP) really OK and should we take him, and Leo said 'yes'. So that was that. The techniques of ultra high vacuum systems had been developed in the 1950s so that for the first time one could do experiments faster than dirt accumulated on a surface; and surface science took off. At that time before computing got into a useful stride, there were very few theoreticians around. As my professor in New Zealand expressed it to me when I said I wanted to do theory, he said there weren't any jobs in theoretical physics because it only took the Fermi's and Mott's of this world ten seconds to have an idea, and that was how it went. Indeed my first job in Cambridge was to 'demonstrate' (teach) in laboratory classes. In the 1960s it was obvious that low energy electron diffraction (LEED) would clearly be extremely important for determining surface structures if one could only understand what it was telling one. X-ray and neutron diffraction were used to determine solid structures, and so why not electron diffraction for surfaces? Electrons in the 0-100 eV range have a suitable wavelength. However they scatter extremely strongly from atomic potentials, and so the scattering pattern is much more complex than with x-rays or neutrons from bulk, where each photon or neutron is only scattered once. Well, we knew about solving the electronic structure for the conduction (valence) electrons in a solid, and so why not have a go in the LEED energy range. That was the project I suggested to John for his PhD, and it worked. The only trouble was that the calculations took forever, because one had to solve the Schrödinger equation for the whole system of vacuum plus solid together: there didn't seem to be any short cut. It was John who saw that there was a possible short cut. He is one of the few research students that I have had who did things independently that I could never have done myself. Although the forward scattering is indeed very strong, he noticed that the back scattering is much weaker, and this allowed him to develop a method of successive approximation. The material and the calculation are cut up into a series of atomic slices, and the electronic structure solved without approximation in each slice. Being two-dimensional, this was much more manageable than a full three-dimensional calculation. Then the slices could be put together by a sort of perturbation theory to calculate the scattering current as a function of energy along each of the reciprocal lattice 'rods' allowed by the surface periodicity. John didn't just stop at having solved the problem in principle, he also developed a suite of computer codes to do the job in a routine way. He even published the code for all to use, and I believe that to the present day the calculations are still done effectively in the same way. Without the calculations, one cannot interpret the data in terms of a surface atomic structure. Effectively one is doing a computer experiment in parallel to the laboratory experiment, and one fiddles more or less systematically with the surface structure until one gets agreement between the simulations and the laboratory data. One of the things that John noticed was that the process of photoemission (UPS) from a surface is rather similar, and can be calculated in an analogous way. This suddenly became very important because the new synchrotron at Daresbury was about to become operational, pumping out billions of photons for solid state research. Sam Edwards (now Sir Sam) was head of SRC (forerunner of EPSRC) at the time and recognised the problem of interpreting all the data that the machine would provide. And after UPS would come EXAFS, and after that XANES and all the rest of the alphabet soup. With that foresight, unusual at the time, John Pendry was appointed to head the theory group at Daresbury. Previously the theoreticians had revolved around the nuclear physics accelerator, and John had to turn it completely around and refocus it, which he did, ably supported and abetted by Phil Burke as head of the Theory and Computational Science Division. 1Cavendish Laboratory, J J Thomson Avenue, Cambridge CB3 0HE, UK Selected Bibliography [1] Pendry J B 1968 J. Phys. C: Solid State Phys. 1 1065-74 [2] Andersson S and Pendry J B 1972 J. Phys. C: Solid State Phys. 5 L41-5 [3] Pendry J B 1974 Low Energy Electron Diffraction (London: Academic Press) [4] Pendry J B 1980 J. Phys. C: Solid State Phys. 13 937-44 [5] Rous P J and Pendry 1989 Surf. Sci. 219 355-72 [6] Saldin D K, Pendry J B, Van Hove M A and Somorjai G A 1985 Phys. Rev. B 31 1216-8 [7] Heinz K, Saldin D K and Pendry J B 1985 Phys. Rev. Lett. 55 2312-5 [8] Lee P A and Pendry J B 1975 Phys. Rev. B 11 2795-811 [9] Pendry J B 1976 Surf. Sci. 57 679-705 [10] Pendry J B 1980 Phys. Rev. Lett. 45 1356-8 [11] Pendry J B and Gurman S J 1975 Surf. Sci. 49 87-105 [12] Echenique P M and Pendry J B 1978 J. Phys. C: Solid State Phys. 11 2065-75 [13] Slevin K M and Pendry J B 1988 J. Phys. C: Solid State Phys. 21 141-9 [14] Pendry J B and Castaño E 1988 J. Phys. C: Solid State Phys. 21 4333-55 [15] Pendry J B, MacKinnon A and Prêtre A B 1990 Physica A 168 400-7 [16] Pendry J B and Gard P 1975 J. Phys. C: Solid State Phys. 8 2048-58 [17] Ward A J and Pendry J B 1996 J. Mod. Opt. 43 773-93 [18] Tsai Y-C, Pendry J B and Shung K W-K 1999 Phys. Rev. B 59 15261-6 [19] Porto J A, García-Vidal F J and Pendry J B 1999 Phys. Rev. Lett. 83 2845-8 [20] Pendry J B 1997 J. Phys.: Condens. Matter 9 10301-20 [21] Pendry J B, Holden A J, Stewart W J and Youngs I 1996 Phys. Rev. Lett. 76 4773-6 [22] Pendry J B, Holden A J, Robbins D J and Stewart W J 1998 J. Phys.: Condens. Matter 10 4785-809 [23] Pendry J B, Holden A J, Robbins D J and Stewart W J 1999 IEEE Trans. Microw. Theory Tech. 47 2075-84 [24] Smith D R, Pendry J B and Wiltshire M C K 2004 Science 305 78-92 [25] Pendry J B 2000 Phys. Rev. Lett. 85 3966-9 [26] Wiltshire M C K, Hajnal J V, Pendry J B, Edwards D J and Stevens C J 2003 Opt. Express 11 709-15 [27] Pendry J B, Schurig D and Smith D R 2006 Science 312 1780-2 [28] Schurig D, Mock D D, Justice B J, Cummer S A, Pendry J B, Starr A F and Smith D R 2006 Science 314 977-80 Due to a typesetting error, corrections were made to p 5 of this article on 10 July 2008. The corrected electronic version is identical to the print version.

  13. EPA Facility Registry Service (FRS): FRS_ESF10

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web service contains the following layers: RMP, TRI, FRP, RCRATSD, CERCLIS, TSCA, and E-PLAN facilities and their associated CONTACTS, CHEMICALS, NAIP, SIC, and...

  14. EPA Facility Registry Service (FRS): FRS_ESF3

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web service contains the following layers: WWTP -NPDES and WTP. The WWTP-NPDES facilties have associated CONTACTS, NAIP, SIC, and STATE IDs information. Layers...

  15. EPA Facility Registry Service (FRS): FRS_ESF3

    Science.gov (United States)

    This web service contains the following layers: WWTP -NPDES and WTP. The WWTP-NPDES facilties have associated CONTACTS, NAIP, SIC, and STATE IDs information. Layers are drawn at a scale of 1: 2311162.217155 and larger. Data used to create this web service are available as a separate download at the Secondary Linkage listed above. Full FGDC metadata records for each layer may be found by clicking the layer name in the web service table of contents (available through the online link provided above) and viewing the layer description.

  16. EPA Facility Registry Service (FRS): FRS_ESF10

    Science.gov (United States)

    This web service contains the following layers: RMP, TRI, FRP, RCRATSD, CERCLIS, TSCA, and E-PLAN facilities and their associated CONTACTS, CHEMICALS, NAIP, SIC, and STATE IDs information. Layers are drawn at scale of 1: 18,489,297 and lower. Data used to create this web service are available as a separate download at the Secondary Linkage listed above. Full FGDC metadata records for each layer may be found by clicking the layer name in the web service table of contents (available through the online link provided above) and viewing the layer description.

  17. R4FRS_RCRAINFO

    Data.gov (United States)

    U.S. Environmental Protection Agency — To improve public health and the environment, the United States Environmental Protection Agency (USEPA) collects information about facilities, sites, or places...

  18. FRS Geospatial Return File Format

    Science.gov (United States)

    The Geospatial Return File Format describes format that needs to be used to submit latitude and longitude coordinates for use in Envirofacts mapping applications. These coordinates are stored in the Geospatail Reference Tables.

  19. Investigation of the isochronous mode of the experimental storage ring (ESR) and the collector ring (CR). Decay spectroscopy of highly charged stored {sup 140}Pr ions at the FRS-ESR facility

    Energy Technology Data Exchange (ETDEWEB)

    Litvinov, Sergey A.

    2008-11-15

    The combination of the present fragment separator FRS and the cooler-storage ring ESR at GSI provides conditions for accurate mass and unique half-life measurements of exotic nuclei. A major part of this doctoral work has been devoted to investigations of the isochronous ion-optical operating mode of the present ESR facility and the planned Collector Ring (CR) facility at FAIR. A detailed ion-optical study of the isochronous storage ring with the emphasis on the main parameters has been done. For example, a simple scaling law providing a quantitative estimate for the mass resolving power as a function of the transverse acceptance has been derived. The ion-optical matching of the FRS-ESR has been calculated and experimentally verified for both the standard and the isochronous operating modes of the ESR. In addition, the dispersion function of a stored ion beam has been measured for both ion-optical modes at the straight section. The improved setting for higher transmission in the standard mode has been used in an experiment on the half-life measurements of highly-charged ions. Orbital electron capture (EC) and/or {beta}{sup +}-decay rates of {sup 140}Pr ions with zero-, one- and two- bound electrons have been measured. A complementary future study of EC-decay in highly-charged {sup 64}Cu ions is discussed. Based on the present experience, the ion-optical matching between the future in-flight fragment separator Super-FRS and the CR has been calculated. The isochronous mode of the CR has been calculated. A dedicated Monte-Carlo code (ISOCHRON) has been developed in order to investigate the influence of the transverse acceptance, the closed orbit distortions, the fringe fields of the quadrupoles, the magnetic field imperfections of the magnets on the mass resolving power. The influence of chromaticity on the isochronicity has been investigated. The correction of the chromaticity and of second-order isochronicity has been performed employing sextupole magnets in the

  20. 'Transnationalism and the Hyphen: Randolph Bourne and Raphael Hawaweeny'

    DEFF Research Database (Denmark)

    Lock, Charles

    2016-01-01

    On the political controversy around the use of the hyphen in labelling Americans identity (Irish-American, German-American) at the time of the First World War.......On the political controversy around the use of the hyphen in labelling Americans identity (Irish-American, German-American) at the time of the First World War....

  1. Definition issues of concepts of social cleavages in Africa | Raphael ...

    African Journals Online (AJOL)

    The main problem is whether the definitions of concepts are coherent to reflect the complex social realities. Based on the theoretical framework and on the analysis of the definitions, it becomes clear that the social cleavage concepts are not consistent once applied to African societies. For the Rwandan society in particular, ...

  2. FRS Download Summary and Data Element Dictionary ...

    Science.gov (United States)

    ECHO, Enforcement and Compliance History Online, provides compliance and enforcement information for approximately 800,000 EPA-regulated facilities nationwide. ECHO includes permit, inspection, violation, enforcement action, and penalty information about facilities regulated under the Clean Air Act (CAA) Stationary Source Program, Clean Water Act (CWA) National Pollutant Elimination Discharge System (NPDES), and/or Resource Conservation and Recovery Act (RCRA). Information also is provided on surrounding demographics when available.

  3. EPA Facility Registry Service (FRS): Power Plants

    Data.gov (United States)

    U.S. Environmental Protection Agency — This GIS dataset contains data on power plants, based on the Energy Information Administration's EIA-860 dataset and supplemented with data from EPA's Facility...

  4. EPA Facility Registry Service (FRS): CERCLIS

    Data.gov (United States)

    U.S. Environmental Protection Agency — This data provides location and attribute information on Facilities regulated under the Comprehensive Environmental Responsibility Compensation and Liability...

  5. EPA Facility Registry Service (FRS): ER_NAICS

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    U.S. Environmental Protection Agency — To improve public health and the environment, the United States Environmental Protection Agency (USEPA) collects information about facilities, sites, or places...

  6. EPA Facility Registry Service (FRS): ER_CHEMICALS

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    U.S. Environmental Protection Agency — To improve public health and the environment, the United States Environmental Protection Agency (USEPA) collects information about facilities, sites, or places...

  7. EPA Facility Registry Service (FRS): ER_SIC

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    U.S. Environmental Protection Agency — To improve public health and the environment, the United States Environmental Protection Agency (USEPA) collects information about facilities, sites, or places...

  8. EPA Facility Registry Service (FRS): ER_STATE_ID

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    U.S. Environmental Protection Agency — To improve public health and the environment, the United States Environmental Protection Agency (USEPA) collects information about facilities, sites, or places...

  9. EPA Facility Registry Service (FRS): ER_WTP

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    U.S. Environmental Protection Agency — To improve public health and the environment, the United States Environmental Protection Agency (USEPA) collects information about facilities, sites, or places...

  10. HISTORICAL NOTE JOHN HUNTER (SURGEON) John Hunter FRS ...

    African Journals Online (AJOL)

    Smellie's work was particularly high for that locality and time; the prevalence of preeclampsia, a common condition affecting ten percent of all pregnancies and one easily treated today but for which there was no treatment in Hunter's time, would more than suffice to explain a mortality rate that seems suspiciously high to 21st ...

  11. EPA Facility Registry Service (FRS): NPDES Sub Facilities

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    U.S. Environmental Protection Agency — As authorized by the Clean Water Act, the National Pollutant Discharge Elimination System (NPDES), permit program controls water pollution by regulating point...

  12. EPA Facility Registry Service (FRS): ER_CONTACTS

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    U.S. Environmental Protection Agency — To improve public health and the environment, the United States Environmental Protection Agency (USEPA) collects information about facilities, sites, or places...

  13. EPA Facility Registry Service (FRS): AIRS_AFS Sub Facilities

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Air Facility System (AFS) contains compliance and permit data for stationary sources regulated by EPA, state and local air pollution agencies. The sub facility...

  14. John Alexander Sinton, MD FRS VC (1884-1956).

    Science.gov (United States)

    Cook, G C

    2016-05-01

    Brigadier John Sinton is the only individual in history to have been both awarded the Victoria Cross and also elected to the Royal Society. He qualified at Belfast and afterwards joined the Indian Medical Service (IMS). Serving before and during the Great War (1914-18), he was first posted to the North-West Frontier province, and afterwards as a captain in the Indian Expeditionary force in Mesopotamia (now Iraq). It was there in 1916 that, shot in both arms during an engagement and under heavy gunfire, he remained steadfastly at his post; for this bravery he received the Victoria Cross. Following the war he carried out major researches into malaria in India, and became Director of the Malaria Survey of India Both there and shortly afterwards, Sinton published about 200 papers on various aspects of malaria and leishmaniasis. In England, he later worked at the London School of Hygiene and Tropical Medicine and the Ministry of Health's laboratory at Horton, Epsom. In 1946, he was elected to the Royal Society for his researches into malaria and kala-azar, and following retirement he underwent another distinguished career in Northern Ireland. © The Author(s) 2014.

  15. Chemical and spectroscopic investigation of the Raphael's cartoon of the School of Athens from the Pinacoteca Ambrosiana

    Science.gov (United States)

    Ioele, Marcella; Sodo, Armida; Casanova Municchia, Annalaura; Ricci, Maria Antonietta; Russo, Alfonso Pio

    2016-12-01

    The cartoon of "The School of Athens", realized by the famous artist Raffaello Sanzio, is a masterpiece of Italian Renaissance. It is a full-scale (804 × 285 cm2) preparatory cartoon, stored at the Pinacoteca Ambrosiana (Milan, Italy). In order to characterize the cartoon and the drawing and to investigate its conservation state, several scientific analyses have been performed, both in situ and on sampled fragments. This multi-analytical approach has identified most of the materials used in the original drawing and in restored areas and provided a map of previous restoration works. Here we report the results obtained by Raman and FTIR spectroscopy, scanning electron microscopy equipped with X-ray micro-analysis (SEM-EDS), pH measurements and micro-chemical tests. pH measurements proved the absence of an acidic decay of the paper. The original paper from linen and hemp fibres is well preserved. It is filled with calcium carbonate and has received a light sizing with protein glue, now almost completely transformed into oxalates. 1797 French intervention paper is of lower quality and has been covered with a patina of lead white in Arabic gum, most likely in an attempt to match the colour to the tone of the original. Both papers are stuck to a support paper with flour glue (containing starch and gluten) and glued with the same adhesive to a canvas lining. In situ Raman spectroscopy has clearly shown that the original drawing was in charcoal and lead white, while the restored areas have been drawn using charcoal and graphite.

  16. The Scientific Publications of Richard H. Dalitz, FRS (1925-2006)

    Energy Technology Data Exchange (ETDEWEB)

    Aitchison, Ian J.R.; Close, Frank E.; Gal, Avraham; Millener, D.John

    2006-03-29

    Professor Richard H. Dalitz passed away on January 13, 2006. He was almost 81 years old and his outstanding contributions are intimately connected to some of the major breakthroughs of the 20th century in particle and nuclear physics. These outstanding contributions go beyond the Dalitz Plot, Dalitz Pair and CDD poles that bear his name. He pioneered the theoretical study of strange baryon resonances, of baryon spectroscopy in the quark model, and of hypernuclei, to all of which he made lasting contributions. His formulation of the ''{theta} - {tau} puzzle'' led to the discovery that parity is not a symmetry of the weak interactions. A brief scientific evaluation of Dalitz's major contributions to particle and nuclear physics is hereby presented, followed by the first comprehensive list of his scientific publications, as assembled from several sources. The list is divided into two categories: the first, main part comprises Dalitz's research papers and reviews, including topics in the history of particle physics, biographies and reminescences; the second part lists book reviews, public lectures and obituaries authored by Dalitz, and books edited by him. This provides the first necessary step towards a more systematic research of the Dalitz heritage in modern physics.

  17. Wheelwright of the heavens. The life & work of James Ferguson, FRS.

    Science.gov (United States)

    Millburn, J. R.; King, H. C.

    This book is a biography of James Ferguson (1710 - 1776), famous for his clocks with astronomical and tidal dials, and for his mechanical models of the solar system ("orreries"). He is also known as producer of terrestrial globes and as prolific writer on astronomy, mechanics, electricity and horology.

  18. Galaxies and their Masks A Conference in Honour of K.C. Freeman, FRS

    CERN Document Server

    Block, David L; Puerari, Ivânio

    2010-01-01

    Various kinds of masks obscure our view of our galaxy, the Milky Way, as well as of other galaxies. Masks of interstellar dust affect our measurements within galaxies, on scales ranging from individual supernovae to the galaxies themselves. The “mass mask” (our inability to image mass rather than light) gives astronomers a very incomplete picture of the size and structure of galaxies themselves, because we cannot image the dark matter which provides most of the galactic mass. Another mass is the “dynamical mask”: as galaxies form, much dynamical information is lost in the birthing process. A new thrust in research is to retrieve such information by means of chemical tagging. About 50 astronomers flew into Namibia in April 2010, to celebrate the 70th birthday of Professor K.C. Freeman, Fellow of the Royal Society. At age 70, Freeman, a father of dark matter in galaxies, continues to be one of planet’s most highly cited astronomers. The current volume affords readers a unique perspective on galaxies b...

  19. John Goodsir FRS (1814-1867): Pioneer of cytology and microbiology.

    Science.gov (United States)

    Gardner, Dugald

    2017-05-01

    John Goodsir, pioneer of the concept that all tissues are formed of cells, was born in 1814 into a family of medical practitioners in Anstruther, Fife, Scotland where he was captivated by the marine life he saw daily in his childhood. His ambition was to follow his father and grandfather in medicine. Aged 13, he studied at St Andrews University before being apprenticed to an Edinburgh dentist and completing an original analysis of the embryology of human dentition. He became the student of Robert Knox at the Royal College of Surgeons of Edinburgh and then Conservator of the University Anatomy museum. He exchanged this position for one at the College of Surgeons before accepting the full University post. Beginning in 1830 with the compound microscope, he studied natural history and anatomy, describing his discoveries to many societies. Appointed to the Edinburgh Chair of Anatomy in 1846, his investigations of the cell as the unit of all tissues were recognised internationally. A critic of Darwin, he believed that Man could not evolve. However, malnutrition, the death of a brother and of a friend and collaborator, Edward Forbes, contributed to progressive illness and Goodsir died at Wardie, Edinburgh in 1867.

  20. The life and viper of Dr Patrick Russell MD FRS (1727-1805): physician and naturalist.

    Science.gov (United States)

    Hawgood, B J

    1994-11-01

    It is nearly two hundred years since the publication in 1796 of An Account of Indian Serpents collected on the Coast of Coromandel by Patrick Russell. Within the folio is a drawing and description of the venomous snake called Katuka Rekula Poda in the local Telugu language, whose venom was shown experimentally by Dr Russell to be nearly as lethal as that of Cobra de Capello. The snake is now known as Vipera russelli or Russell's viper. Dr Russell was representative of the naturalistic tendency of British medicine in the late 18th century. He was a keen observer and skilled doctor in clinical practice, particularly in Aleppo, Syria, during an outbreak of the plague, and indefatigable in his study of plant and animal life both in Aleppo and later in the Madras Province of India. As a physician as well as Naturalist to the East India Company in the Carnatic he was concerned with the problem of snakebite. His first aim was to find a means whereby the non-specialist could distinguish between poisonous and harmless snakes and so combat the terrible notion that all bites were mortal. His writing, encompassing social and natural histories and climaxed by a study of snakes, has left a rich legacy. Dr Patrick Russell was a man of the highest integrity and ability, a physician and naturalist par excellence.

  1. The Reverend Thomas Bayes, FRS: A Biography to Celebrate the Tercentenary of His Birth

    Science.gov (United States)

    Bellhouse, D. R.

    2004-07-01

    Thomas Bayes, from whom Bayes theorem takes its name, was probably born in 1701, so the year 2001 marked the 300th anniversary of his birth. This biography was written to celebrate this anniversary. The current sketch of his life includes his family background and education, as well as his scientific and theological work. In contrast to some, but not all, biographies of Bayes, the current biography is an attempt to cover areas beyond Bayes' scientific work. When commenting on the writing of scientific biography, Pearson [(1978). The History of Statistics in the 17th and 18th Centuries.... Charles Griffin and Company, London] stated, "it is impossible to understand a man's work unless you understand something of his character and unless you understand something of his environment. And his environment means the state of affairs social and political of his own age." The intention here is to follow this general approach to biography. There is very little primary source material on Bayes and his work. For example, only three of his letters and a notebook containing some sketches of his own work, almost all unpublished, as well as notes on the work of others are known to have survived. Neither the letters nor the notebook is dated, and only one of the letters can be dated accurately from internal evidence. This biography contains new information about Bayes. In particular, among the papers of the 2nd Earl Stanhope, letters and papers of Bayes have been uncovered that previously were not known to exist. The letters indirectly confirm the centrality of Stanhope in Bayes' election to the Royal Society. They also provide evidence that Bayes was part of a network of mathematicians initially centered on Stanhope. In addition, the letters shed light on Bayes' work in infinite series.

  2. H. Raphael-Hernandez on A. D. Nieves and L. M. Alexander’s “We Shall Independent Be”: African American Place Making…

    Directory of Open Access Journals (Sweden)

    2009-11-01

    Full Text Available Angel David Nieves and Leslie M. Alexander. Eds. “We Shall Independent Be”: African American Place Making and the Struggle to Claim Space in the United States. Boulder: UP of Colorado, 2008. xvi + pp. 538.In their collection of essays, Angel David Nieves and Leslie M. Alexander offer a space to twenty contributors who explore the history of the African American search and struggle to claim particular public places in the United States that were necessary for African American survival and tran...

  3. KINETICS AND MECHANISM OF REACTION OF ACIDIC ...

    African Journals Online (AJOL)

    For both Nile blue and Meldola\\'s blue reactions the rates have first-order dependence on each substrate, chlorite and acid. Both reactions showed negative salt effect indicating the reaction is between the oppositely charged species, likely the substrate cation and chlorite anion. The acidic chlorite reaction with MB+ was ...

  4. Joseph Needham, CH, FRS, FBA., b. 9 December 1900; d. 24 April 1995. A Sailor's Tribute and a Memoir

    Science.gov (United States)

    Waters, D. W.

    Sailors, indeed anyone interested in the development of sailing craft, will be for ever indebted to Joseph Needham. Today they will find with ease literature that describes the origins, characteristics, and development of sailing craft in the various regions of the world; the inter-relationships between natural products, and native hull stuctures and forms, sails' fabrics, shapes, and performance. They can learn, too, that the closestowing anchor, the water-tight bulkhead, the balanced rudder (and other features of the modern efficiency-conscious ship constructor) have all been adapted from the millenniaold, so-long-despised by Westerners, Chinese junk, just as has, late in this twentieth century, the stiffened sail of the modern high-performance yacht.

  5. Neil Hamilton Fairley KBE FRCP FRS (1891-1966): an outstanding tropical physician in the twentieth century.

    Science.gov (United States)

    Cook, G C

    2014-11-01

    In the late nineteenth and early twentieth centuries, British physicians led the way in tropical medicine research. Several years later scientific advances had slowed, and Fairley's numerous contributions were thus most welcome. Neil Hamilton Fairley was born of Scottish parents at Victoria, Australia. After qualification at Melbourne, he joined the Australian Army Medical Service (AAMS) and after several minor research projects, made valuable contributions to the understanding of tropical sprue at Bombay (now Mumbai), India. However, Fairley's major researches were carried out during World War II (1939-45). Together with J S K Boyd he demonstrated the great value of sulphaguanidine in bacillary dysentery. Working in northern Australia and the south-Pacific region, he both contributed to elucidation of the Plasmodium vivax life-cycle, and more importantly demonstrated the value of alternative anti-malarial compounds to quinine (which was not readily available). Back in London after the war, Fairley briefly occupied the Wellcome Chair of Tropical Medicine, strongly supported London's clinical tropical medicine, and was subsequently knighted in 1950. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  6. The role of exogenous electron carriers in NAD(P)-dependent dehydrogenase cytochemistry studied in vitro and with a model system of polyacrylamide films

    NARCIS (Netherlands)

    van Noorden, C. J.; Tas, J.

    1982-01-01

    The applicability of phenazine methosulfate, 1-methoxyphenazine methosulfate, menadione, and meldola blue as exogenous electron carriers for the cytochemical staining of nicotinamide adenine dinucleotide (phosphate) (NAD(P))-dependent dehydrogenases has been studied quantitatively with tetranitro BT

  7. Browse Author Index

    African Journals Online (AJOL)

    Items 101 - 150 of 244 ... Musila, F. Musiliu, Olayide Popoola · Musiomi, TM · Muthakia, Gerald K. Muthengia, Wachira J. Mutothia, FU · Mutuku, Raphael N · Mutuku, Raphael N. Mutuku, Raphael N. Mwangi, GM · Mwangi, JK · Mwangi, JM · Mwangi, John K. Mwea, Sixtus Kinyua · Mwea, SK · Mwero, JN · Mwishwa, YHB ...

  8. Jacob Christian Schäffer FRS, a versatile eighteenth-century naturalist, and his remarkable pioneering researches on microscopic crustaceans.

    Science.gov (United States)

    Fryer, Geoffrey

    2008-06-20

    Jacob Christian Schäffer was the first to appreciate the morphological complexity of the microscopic crustacean Daphnia. His investigations, published in 1755, provide an excellent example of the difficulties facing those who, for the first time, attempted to elucidate the structure of extremely complicated animals of small size, of which there were no familiar counterparts. Nevertheless he not only revealed many hitherto unsuspected anatomical features but attempted, with some success, to explain their function. Most notably he showed that Daphnia produces a current of water that draws suspended particles into its complex food-handling machinery. An earlier suggestion of how it feeds was completely erroneous and misleading. A pioneer of the comparative method, Schäffer provided an excellent example of how it helped him to understand, if not entirely to resolve, a complicated mechanism. That reproduction can be either parthenogenetic or sexual presented problems that were not resolved for more than another century. Unaware that males exist, and on the basis of seemingly sound, but misleading, observations, he concluded that Daphnia is a hermaphrodite.

  9. Denis Parsons Burkitt CMG, MD, DSc, FRS, FRCS, FTCD (1911-93) Irish by birth, Trinity by the grace of God.

    Science.gov (United States)

    Smith, Owen

    2012-03-01

    Denis Parsons Burkitt, surgeon and research scientist, is a household name in the medical profession. Denis received his BA in 1933 and graduated as a physician in 1935 from Trinity College, Dublin. After serving as a surgeon in the Royal Army Medicine Corps during World War II, he worked as a surgeon and lecturer in Africa. It was in Africa that he developed exceptional observational and analytical skills, which led him to identify and formally develop a successful treatment for a childhood cancer that is now called Burkitt Lymphoma. The influence of Christianity in his life was huge. Throughout his life he remained extremely modest, attributing much of what he had achieved to the work of others. Denis's contributions to haemato-oncology remain salient today, and his discoveries continue to generate new research. Throughout his career he received some of the highest scientific honours from many different countries across the globe. © 2012 Blackwell Publishing Ltd.

  10. Henry Selby Hele-Shaw LLD, DSc, EngD, FRS, WhSch (1854-1941: Engineer, inventor and educationist

    Directory of Open Access Journals (Sweden)

    Jane Carruthers

    2010-03-01

    Full Text Available H.S. Hele-Shaw (1854–1941 was one of the most outstanding engineering scientists of his generation and an eminent figure in engineering education during the late-19th and early-20th centuries. His work in hydrodynamics (the Hele-Shaw cell and Hele-Shaw pump and his important contribution to the successful development of high-speed aircraft (his variable pitch airscrew, continues to be relevant today. In 1922, as President of the Institution of Mechanical Engineers, he introduced the National Certificate scheme in Britain. It is not well known that Hele-Shaw spent two years in South Africa (1904–1905 attached to the Transvaal Technical Institute, a forerunner of the University of the Witwatersrand. One of only three Fellows of the Royal Society of London in southern Africa in 1905, he was a founder Council member of the Royal Society of South Africa and one of the hosts of the 1905 visit to southern Africa by the British Association for the Advancement of Science. The purpose of this paper is to highlight the time he spent in South Africa and to contextualise it within the larger perspective of his engineering career.

  11. Untitled

    African Journals Online (AJOL)

    to construct a glucose biosensor for FI application [9]. It strongly adsorbs on graphite surface and promotes the electrocatalytic oxidation of NADH. The mechanism of reaction is tentatively assumed to be the same as those of other phenoxazines presented elsewhere (e.g.. Meldola's Blue [30]). A chemical oxidation step of ...

  12. kinetics and mechanism of reaction of acidic chlorite with ...

    African Journals Online (AJOL)

    overall third order rate constants for the reaction of acidic chlorite with Nile blue and Meldola's blue were (0.363 ... of interest to investigate, how these differences affect the reaction rates of these dyes with acidic chlorite. .... To establish the order with respect to chlorite and acid, the effect of initial concentration of chlorite and ...

  13. Superfund/IGD: EF_NPL

    Data.gov (United States)

    U.S. Environmental Protection Agency — EF_NPL is a subset of facilities from FRS_INTEREST and FRS_FACILITY_SITE which are updated on a monthly basis as part of the Locational Reference Tables (LRT)...

  14. Hazardous Waste/IGD: EF_RCRA

    Data.gov (United States)

    U.S. Environmental Protection Agency — EF_RCRA is a subset of facilities from FRS_INTEREST and FRS_FACILITY_SITE which are updated on a monthly basis as part of the Locational Reference Tables (LRT)...

  15. Water Dischargers/IGD: EF_NPDES

    Data.gov (United States)

    U.S. Environmental Protection Agency — EF_NPDES is a subset of facilities from FRS_INTEREST and FRS_FACILITY_SITE which are updated on a monthly basis as part of the Locational Reference Tables (LRT)...

  16. Air Emissions/IGD: EF_AFS

    Data.gov (United States)

    U.S. Environmental Protection Agency — EF_AFS is a subset of facilities from FRS_INTEREST and FRS_FACILITY_SITE which are updated on a monthly basis as part of the Locational Reference Tables (LRT)...

  17. Brownfields/IGD: EF_ACRES

    Data.gov (United States)

    U.S. Environmental Protection Agency — EF_ACRES is a subset of facilities from FRS_INTEREST and FRS_FACILITY_SITE which are updated on a monthly basis as part of the Locational Reference Tables (LRT)...

  18. The StreamCat Dataset: Accumulated Attributes for NHDPlusV2 Catchments (Version 2.1) for the Conterminous United States: Facility Registry Services (FRS) : Toxic Release Inventory (TRI) , National Pollutant Discharge Elimination System (NPDES) , and Superfund Sites

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset represents the estimated density of georeferenced sites within individual, local NHDPlusV2 catchments and upstream, contributing watersheds based on the...

  19. The StreamCat Dataset: Accumulated Attributes for NHDPlusV2 (Version 2.1) Catchments for the Conterminous United States: Facility Registry Services (FRS) : Toxic Release Inventory (TRI) , National Pollutant Discharge Elimination System (NPDES) , and Superfund Sites

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset represents the estimated density of georeferenced sites within individual, local NHDPlusV2 catchments and upstream, contributing watersheds based on the...

  20. Effect of Production System on Welfare Traits, Growth Performance ...

    African Journals Online (AJOL)

    Duck feather quality was greater and gait defects were reduced in NRS system compared with FRS and WRS systems. Fluctuating asymmetry (FA) was not affected by the production system. Growth performance was not significantly different between FRS and WRS systems. Average daily weight gain of FRS ducks was ...

  1. First rank symptoms: concepts and diagnostic utility | Saddichha ...

    African Journals Online (AJOL)

    First Rank Symptoms (FRS) were first defined by Schneider as diagnostic of schizophrenia. Since then, there has been an immense debate on their diagnostic and prognostic utility. This review attempts to understand the concepts of FRS as depicted over the years and the diagnostic and prognostic implications of FRS in ...

  2. Clipboard: Endocannabinoid signalling is required for estrogen ...

    Indian Academy of Sciences (India)

    jbsc/037/06/0921-0923. Keywords. Disinhibition; endocannabinoid; hippocampus; information gating; plasticity. Author Affiliations. Liisa A Tremere1 Raphael Pinaud1. Department of Neurobiology, Northwestern University Evanston, IL, USA ...

  3. Legionnaires’ Disease and Compost

    Centers for Disease Control (CDC) Podcasts

    2017-09-27

    Dr. Brian Raphael, a CDC research microbiologist, discusses Legionella bacteria in compost.  Created: 9/27/2017 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 9/27/2017.

  4. Eesti kunstniku Rafael Arutjunjani personaalnäitus Riias

    Index Scriptorium Estoniae

    2006-01-01

    12.05 - 9.06 2006 Rafael Arutjunjani tööde näitusest Nelia galeriis. 19.05.2006 tema loomingule pühendatud raamatu "Raphael Arutyunyan artistic production" presentatsioonist Riias Janis Roze raamatupoes

  5. Automated external defibrillator (AED) utilization rates and reasons fire and police first responders did not apply AEDs.

    Science.gov (United States)

    Lerner, E Brooke; Billittier, Anthony J; Newman, Mary M; Groh, William J

    2002-01-01

    To determine the rate at which fire and police first responders (FRs) apply automated external defibrillators (AEDs) and to ascertain reasons for not applying them. Twenty-one emergency medical services (EMS) systems whose FRs had been supplied with AEDs by a philanthropic foundation provided data for all out-of-hospital cardiac arrest (OHCA) patients. Data including the incidence of AED application and explanations for not applying AEDs were analyzed using descriptive statistics. A total of 2,456 OHCAs were reported. AED application information was available for 2,439 patients and revealed that FRs had not applied AEDs to 1,025 patients (42%). Fire FRs were more likely than police FRs to have applied AEDs (relative risk 1.87, 95% confidence interval 1.65-2.12). Reasons for not applying AEDs were listed for 664 (65%) of the OHCA patients to whom AEDs had not been applied. The predominant reason the FRs did not apply an AED was that the transporting ambulance defibrillator had already been applied (74%). However, when response times for FRs and the transporting ambulances were compared for these OHCA patients, it was found that the transporting ambulances arrived after the FRs 23% the time, simultaneously with the FRs 45% of the time, and before the FRs only 32% of the time. Fire and police FRs did not apply AEDs to a significant number of OHCA patients. Use of the transport ambulance defibrillator was the primary reason given for not applying the FR AED. Given low AED application rates by FRs, future studies are needed to determine the characteristics of communities in which equipping FRs with AEDs is the most beneficial deployment strategy, and how to increase AED application by FRs in communities with FR AED programs.

  6. Filtered Rayleigh scattering diagnostic for multi-parameter thermal-fluids measurements : LDRD final report.

    Energy Technology Data Exchange (ETDEWEB)

    Beresh, Steven Jay; Grasser, Thomas W.; Kearney, Sean Patrick; Schefer, Robert W.

    2004-01-01

    Simulation-based life-cycle-engineering and the ASCI program have resulted in models of unprecedented size and fidelity. The validation of these models requires high-resolution, multi-parameter diagnostics. Within the thermal-fluids disciplines, the need for detailed, high-fidelity measurements exceeds the limits of current engineering sciences capabilities and severely tests the state of the art. The focus of this LDRD is the development and application of filtered Rayleigh scattering (FRS) for high-resolution, nonintrusive measurement of gas-phase velocity and temperature. With FRS, the flow is laser-illuminated and Rayleigh scattering from naturally occurring sources is detected through a molecular filter. The filtered transmission may be interpreted to yield point or planar measurements of three-component velocities and/or thermodynamic state. Different experimental configurations may be employed to obtain compromises between spatial resolution, time resolution, and the quantity of simultaneously measured flow variables. In this report, we present the results of a three-year LDRD-funded effort to develop FRS combustion thermometry and Aerosciences velocity measurement systems. The working principles and details of our FRS opto-electronic system are presented in detail. For combustion thermometry we present 2-D, spatially correlated FRS results from nonsooting premixed and diffusion flames and from a sooting premixed flame. The FRS-measured temperatures are accurate to within {+-}50 K (3%) in a premixed CH4-air flame and within {+-}100 K for a vortex-strained diluted CH4-air diffusion flame where the FRS technique is severely tested by large variation in scattering cross section. In the diffusion flame work, FRS has been combined with Raman imaging of the CH4 fuel molecule to correct for the local light scattering properties of the combustion gases. To our knowledge, this is the first extension of FRS to nonpremixed combustion and the first use of joint FRS

  7. Framingham risk score with cardiovascular events in chronic kidney disease.

    Directory of Open Access Journals (Sweden)

    Szu-Chia Chen

    Full Text Available The Framingham Risk Score (FRS was developed to predict coronary heart disease in various populations, and it tended to under-estimate the risk in chronic kidney disease (CKD patients. Our objectives were to determine whether FRS was associated with cardiovascular events, and to evaluate the role of new risk markers and echocardiographic parameters when they were added to a FRS model. This study enrolled 439 CKD patients. The FRS is used to identify individuals categorically as "low" (4.7 cm, left ventricular hypertrophy or left ventricular ejection fraction<50% to the FRS model significantly improves the predictive values for cardiovascular events. In CKD patients, "high" risk categorized by FRS predicts cardiovascular events. Novel biomarkers and echocardiographic parameters provide additional predictive values for cardiovascular events. Future study is needed to assess whether risk assessment enhanced by using these biomarkers and echocardiographic parameters might contribute to more effective prediction and better care for patients.

  8. Quantitative fuel vapor/air mixing imaging in droplet/gas regions of an evaporating spray flow using filtered Rayleigh scattering.

    Science.gov (United States)

    Allison, Patton M; McManus, Thomas A; Sutton, Jeffrey A

    2016-03-15

    This Letter demonstrates the application of filtered Rayleigh scattering (FRS) for quantitative two-dimensional fuel vapor/air mixing measurements in an evaporating hydrocarbon fuel spray flow. Using the FRS approach, gas-phase measurements are made in the presence of liquid-phase droplets without interference. Effective suppression of the liquid-phase droplet scattering using FRS is enabled by the high spectral purity of the current Nd:YAG laser system. Simultaneous Mie-scattering imaging is used to visualize the droplet field and illustrate the droplet loading under which the FRS imaging is applied in the current spray flows. The initial quantification of the FRS imaging is based on calibration measurements from a flow cell of known fuel vapor/air mixtures, while future work targets the utilization of a Rayleigh-Brillouin spectral model for quantification of the FRS signals.

  9. Food-Related Symptoms and Food Allergy in Swedish Children from Early Life to Adolescence.

    Science.gov (United States)

    Protudjer, Jennifer L P; Vetander, Mirja; Kull, Inger; Hedlin, Gunilla; van Hage, Marianne; Wickman, Magnus; Bergström, Anna

    2016-01-01

    Risk factors for persistence of food-related symptoms (FRS) and food allergy (FA) from early life to adolescence are incompletely understood. The aim of this study was to identify risk factors for FRS and FA in adolescence amongst children with FRS or FA in the first four years of life (early life). In children enrolled in a Swedish birth cohort and followed to 16 years (n = 2572), we defined children with early life FRS in the absence of FA, and FA. Corresponding phenotypes were defined at 16 years. Associations between potential risk factors at 4 years and FRS and FA at 16 years were investigated using logistic regression. Early life FRS and FA prevalences were 12.2% and 6.8%, respectively. Amongst children with early life FRS, 35.7% had FRS or FA at 16 years, whereas 74.3% of the children with early life FA had FA at 16 years. For each of the early life phenotypes, parental allergy, early life allergic multimorbidity, early life reactions to peanuts/tree nuts and IgE reactivity at 4 years were statistically significantly associated with FRS or FA at 16 years. In contrast, male sex was associated with an increased risk of FA at 16 years among children with early life FA only. In early life, food-related symptoms are twice as common as food allergy. Unlike food allergy, food-related symptoms often remit by adolescence. Yet, these phenotypes have many common risk factors for persistence to adolescence.

  10. Biofuel anode for cell reactions involving nicotinamide adenine dinucleotide as a charge carrier

    Energy Technology Data Exchange (ETDEWEB)

    Persson, B.; Gorton, L.; Johansson, G.

    1986-12-01

    Biofuel cell anodes with porous graphitic materials were modified by adsorption of a mediator (N,N-dimethyl-7-amino-1,2-benzophenoxazine, Meldola Blue) for oxidation of the dihydronicotinamide adenine dinucleotide. Electrodes made from reticulated vitreous carbon were already heavily polarized at current densities less than 1 mA cm/sup -2/, mainly because of the low surface coverage with mediator. Graphite-felt electrodes adsorbed the mediator so well that current densities up to about 10 mA cm/sup -2/ could be supported. The cell resistances rather than the catalytic activity were then limiting the current.

  11. New stopping cell capabilities : RF carpet performance at high gas density and cryogenic operation

    NARCIS (Netherlands)

    Ranjan, M.; Purushothaman, S.; Dickel, T.; Geissel, H.; Plass, W. R.; Schaefer, D.; Scheidenberger, C.; Van de Walle, J.; Weick, H.; Dendooven, P.

    2011-01-01

    We have developed a stopping cell to be used at the FRS and Super-FRS (Superconducting FRagment Separator) at the GSI Helmholtz Centre for Heavy-Ion Research and the Facility for Antiproton and Ion Research (FAIR), both in Darmstadt, Germany. The cell has a stopping volume with a length of 1m and a

  12. Relation of Framingham Risk Score to Subclinical Atherosclerosis Evaluated Across Three Arterial Sites

    Science.gov (United States)

    Karim, Roksana; Hodis, Howard N; Detrano, Robert; Liu, Chao-ran; Liu, Chi-hua; Mack, Wendy J

    2008-01-01

    The Framingham risk score (FRS) is widely used in clinical practice to identify subjects at high risk for developing coronary heart disease (CHD). However, FRS may not accurately identify subjects at risk. We measured subclinical atherosclerosis in the coronary arteries and aorta with the presence of calcium (CAC and AC, respectively) and in the common carotid artery by intima-media thickness (CIMT) in 498 healthy subjects. The distribution of these subclinical atherosclerosis measures was evaluated across 3 strata of the FRS. CAC, AC and CIMT were significantly independently associated with FRS. The FRS increased with the number of arterial sites with atherosclerosis. Sixty-nine percent of the subjects categorized in the low risk group (FRS20%) had 1 or more vascular imaging studies demonstrating subclinical atherosclerosis. Among the low risk group, subjects with atherosclerosis had a longer history of lifetime smoking compared to those without atherosclerosis. In conclusion, subclinical atherosclerosis is prominent across the spectrum of FRS. Evaluation of subclinical atherosclerosis in different arterial sites in addition to FRS may be useful in targeting subjects for lifestyle and other interventions. PMID:18805105

  13. s first-rank symptoms in Zulu patients with paranoid schizophrenia

    African Journals Online (AJOL)

    Background: The aim of this study was to examine the prevalence of Schneider's first-rank symptoms (FRS) in Zulu patients diagnosed with paranoid schizophrenia and to ascertain the diagnostic and prognostic significance of Schneider's FRS in this group. Methods: This descriptive study was done on 75 psychiatric Zulu ...

  14. Toxic Releases/IGD: EF_TRI

    Data.gov (United States)

    U.S. Environmental Protection Agency — EF_NPL is a subset of facilities from FRS_INTEREST and FRS_FACILITY_SITE which are updated on a monthly basis as part of the Locational Reference EF_TRI is a subset...

  15. The StreamCat Dataset: Accumulated Attributes for NHDPlusV2 (Version 2.1) Catchments Riparian Buffer for the Conterminous United States: Facility Registry Services (FRS) : Toxic Release Inventory (TRI) , National Pollutant Discharge Elimination System (NPDES) , and Superfund Sites

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset represents the estimated density of georeferenced sites within individual, local NHDPlusV2 catchments and upstream, contributing watersheds riparian...

  16. Recent Precision Experiments with Exotic Nuclei Produced with Uranium Projectiles and Experimental Prospects at Fair

    Directory of Open Access Journals (Sweden)

    Geissel H.

    2014-03-01

    Full Text Available Precision experiments with relativistic fragments separated in-flight require special experimentalmethods to overcome the inherent large emittance from the creation in nuclear reactions and atomic interactions in matter. At GSI relativistic exotic nuclei have been produced via uranium projectile fragmentation and fission and investigated with the inflight separator FRS directly, or in combination with either the storage-cooler ring ESR or the FRS Ion Catcher. 1000 A·MeV 238U ions were used to create 60 new neutron-rich isotopes separated and identified with the FRS to measure their production cross sections. In another experimental campaign the fragments were separated in flight and injected into the storage-cooler ring ESR for accurate mass and lifetime measurements. In these experimentswe have obtained accurate new mass values analyzed via a novel method which has reduced the systematic errors for both Schottky Mass Spectrometry (SMS and for Isochronous Mass Spectrometry (IMS. Pioneering experiments have been carried out with the FRS Ion Catcher consisting of three experimental components, the dispersive magnetic system of the FRS with a monoenergetic and a homogeneous degrader, a cryogenic stopping cell filled with pure helium and a multiple-reflection time-of flight mass separator. The FRS Ion Catcher enables high precision spectroscopy experiments with eV to keV exotic nuclides. Results from these different FRS experiments are presented in this overview together with prospects for the next-generation facility Super-FRS. The novel features of the Super-FRS compared with the present FRS will be discussed in addition.

  17. Recent Precision Experiments with Exotic Nuclei Produced with Uranium Projectiles and Experimental Prospects at Fair

    Science.gov (United States)

    Geissel, H.; Chen, L.; Dickel, T.; Farinon, F.; Dillmann, I.; Knöbel, R.; Kurcewicz, J.; Mukha, I.; Münzenberg, G.; Nociforo, C.; Patyk, Z.; Pietri, S.; Plass, W. R.; Prochazka, A.; Scheidenberger, C.; Takechi, M.; Weick, H.; Winfield, J. S.; Winkler, M.

    2014-03-01

    Precision experiments with relativistic fragments separated in-flight require special experimentalmethods to overcome the inherent large emittance from the creation in nuclear reactions and atomic interactions in matter. At GSI relativistic exotic nuclei have been produced via uranium projectile fragmentation and fission and investigated with the inflight separator FRS directly, or in combination with either the storage-cooler ring ESR or the FRS Ion Catcher. 1000 A·MeV 238U ions were used to create 60 new neutron-rich isotopes separated and identified with the FRS to measure their production cross sections. In another experimental campaign the fragments were separated in flight and injected into the storage-cooler ring ESR for accurate mass and lifetime measurements. In these experimentswe have obtained accurate new mass values analyzed via a novel method which has reduced the systematic errors for both Schottky Mass Spectrometry (SMS) and for Isochronous Mass Spectrometry (IMS). Pioneering experiments have been carried out with the FRS Ion Catcher consisting of three experimental components, the dispersive magnetic system of the FRS with a monoenergetic and a homogeneous degrader, a cryogenic stopping cell filled with pure helium and a multiple-reflection time-of flight mass separator. The FRS Ion Catcher enables high precision spectroscopy experiments with eV to keV exotic nuclides. Results from these different FRS experiments are presented in this overview together with prospects for the next-generation facility Super-FRS. The novel features of the Super-FRS compared with the present FRS will be discussed in addition.

  18. Framingham Score and LV Mass predict Events in Young Adults: CARDIA Study

    Science.gov (United States)

    Armstrong, Anderson C.; Jacobs, David R.; Gidding, Samuel S.; Colangelo, Laura A.; Gjesdal, Ola; Lewis, Cora E.; Bibbins-Domingo, Kirsten; Sidney, Stephen; Schreiner, Pamela J.; Williams, O. D.; Goff, David C.; Liu, Kiang; Lima, Joao A. C.

    2014-01-01

    Background Framingham risk score (FRS) underestimates risk in young adults. LV mass (LVM) relates to cardiovascular disease (CVD), with unclear value in youth. In a young biracial cohort, we investigate how FRS predicts CVD over 20 years and the incremental value of LVM. We also explore the predictive ability of different cut-points for hypertrophy. Methods We assessed FRS and echocardiography-derived LVM (indexed by BSA or height2.7) from 3980 African-American and white CARDIA participants (1990-1991); and followed over 20 years for a combined endpoint: cardiovascular death; nonfatal myocardial infarction, heart failure, cerebrovascular disease, and peripheral artery disease. We assessed the predictive ability of FRS for CVD and also calibration, discrimination, and net reclassification improvement for adding LVM to FRS. Results Mean age was 30±4 years, 46% males, and 52% white. Event incidence (n = 118) across FRS groups was, respectively, 1.3%, 5.4%, and 23.1% (p<0.001); and was 1.4%, 1.3%, 3.7%, and 5.4% (p<0.001) across quartiles of LVM (cut-points 117g, 144g, and 176g). LVM predicted CVD independently of FRS, with the best performance in normal weight participants. Adding LVM to FRS modestly increased discrimination and had a statistically significant reclassification. The 85th percentile (≥116 g/m2 for men; ≥96 g/m2 for women) showed event prediction more robust than currently recommended cut-points for hypertrophy. Conclusion In a biracial cohort of young adults, FRS and LVM are helpful independent predictors of CVD. LVM can modestly improve discrimination and reclassify participants beyond FRS. Currently recommended cut-points for hypertrophy may be too high for young adults. PMID:24507735

  19. Phytochrome B Nuclear Bodies Respond to the Low Red to Far-Red Ratio and to the Reduced Irradiance of Canopy Shade in Arabidopsis1[C][W][OPEN

    Science.gov (United States)

    Trupkin, Santiago Ariel; Legris, Martina; Buchovsky, Ana Sabrina; Tolava Rivero, María Belén; Casal, Jorge José

    2014-01-01

    The current consensus is that plant responses to canopy shade involve the perception of low red to far-red ratios (R:FRs) by phytochrome B (phyB), which leads to the direct activation of auxin synthesis genes by PHYTOCHROME INTERACTING FACTORs (PIFs). In addition to its effect on R:FRs, shade also reduces irradiance, but whether shade-induced drops in irradiance affect phyB activity has not been demonstrated. To address this issue, we investigated whether irradiance and R:FRs have similar effects on the nuclear distribution of phyB in petiole cells of light-grown plants. Under high-irradiance white light, phyB formed large nuclear bodies. Lowering irradiance without changing R:FRs or lowering R:FRs by adding far-red light led to the appearance of small nuclear bodies containing phyB. Large nuclear bodies remained but with some concomitant reduction in diameter. The appearance of small nuclear bodies was rapid, stable, and reversible upon the return to high irradiance and high R:FRs. High levels of red light but not of blue light were enough to restrain the formation of small phyB nuclear bodies. Irradiance was effective within the range found in natural canopies and even under relatively low R:FRs. The promotion of leaf hyponasty by lowering irradiance was impaired in phyB and pif mutants, as previously reported for the response to R:FRs. The expression of auxin-related genes showed a similar hierarchy of response to low R:FRs and low irradiance. We propose that phyB is able to perceive not only the low R:FRs, but also the low irradiance of shade. PMID:24948827

  20. A Knowledge Base for Knowledge-Based Multiagent System Construction

    Science.gov (United States)

    2000-10-01

    step_p.html [5] M. J. Raphael, “Knowledge Based Support for Design and Synthesis of Multiagent Systems.” MS Thesis AFIT/ENG/00M21. School of...Wooldridge, N. Jennings, and D. Kinny, “The Gaia Methodology for Agent-Oriented Analysis and Design,” Journal of Autonomous Agents and Multi-Agent

  1. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 37; Issue 6. Issue front cover thumbnail. Volume 37, Issue 6. December 2012, pages 921-1121. pp 921-923. Clipboard: Endocannabinoid signalling is required for estrogen-dependent modulation of inhibitory transmission · Liisa A Tremere Raphael Pinaud · More Details ...

  2. U.S. EPA and San Francisco Department of the Environment Spotlight Super Bowl Efforts to Feed the Hungry

    Science.gov (United States)

    SAN FRANCISCO - On Wednesday, February 3, U.S. EPA Regional Administrator Jared Blumenfeld will be joined by San Francisco Department of the Environment Director Debbie Raphael, Food Runners Director Mary Risley, and HealthRIGHT 360 CEO Vitka Eisen to dis

  3. Improving Manufacturing Performance in South Africa : Report of the ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    1995-01-01

    Improving Manufacturing Performance in South Africa : Report of the Industrial Strategy Project. Couverture du livre Improving Manufacturing Performance in South Africa. Author(s):. Avril Joffe, David Kaplan, Raphael Kaplinsky et David Lewis. Publisher(s):. UCT Press, CRDI. January 1, 1995. ISBN: Épuisé. 264 pages.

  4. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 34; Issue 2. Issue front cover thumbnail. Volume 34, Issue 2. June 2009, pages 161-331. pp 161-162. Clipboard: mGluR5 is a central regulator of synaptic function and plasticity in the developing mouse barrel cortex · Liisa A Tremere Raphael Pinaud · More Details Fulltext ...

  5. Browse Title Index

    African Journals Online (AJOL)

    Items 251 - 300 of 985 ... Vol 30 (2015), Design and Construction of a Home Automation System Using a Smart Phone, Abstract. Patrick Oshevire, Raphael Akanuoh, ... Vol 19 (2011), Determination of utilizable wind energy for indoor ventilation in buildings across selected locations in Nigeria, Abstract. M Ocholi, EE Iheonu.

  6. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 33; Issue 2. Issue front cover thumbnail. Volume 33, Issue 2. June 2008, pages 157-307. pp 157-158. Clipboard: Recovery from amblyopia in adults via decreased visual cortical inhibition caused by experience in an enriched environment · Liisa A Tremere Raphael Pinaud.

  7. Animal Research International - Vol 12, No 2 (2015)

    African Journals Online (AJOL)

    Assessment of fetal wastage in pigs slaughtered at Kumasi abattoir, Ghana · EMAIL FULL TEXT EMAIL FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Michael Kwaku FRIMPONG, Benjamin Obukowho EMIKPE, Raphael Deladem FOLITSE, Theophilus Aghogho JARIKRE, Nyarko Timothy ASENSO, Derrick ...

  8. The science of marijuana

    National Research Council Canada - National Science Library

    Iversen, Leslie L

    2008-01-01

    ... 1930s, which essentially eliminated all medical research in the field for almost 30 years. This action was tragic for science, as chemists were extremely close to isolating the active chemical ingredient of marijuana prior to World War II. The identification of delta-9tetrahydrocannabinol (THC) had to wait for the elegant efforts of Raphael ...

  9. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects

    OpenAIRE

    Russo, Ethan B

    2011-01-01

    Tetrahydrocannabinol (THC) has been the primary focus of cannabis research since 1964, when Raphael Mechoulam isolated and synthesized it. More recently, the synergistic contributions of cannabidiol to cannabis pharmacology and analgesia have been scientifically demonstrated. Other phytocannabinoids, including tetrahydrocannabivarin, cannabigerol and cannabichromene, exert additional effects of therapeutic interest. Innovative conventional plant breeding has yielded cannabis chemotypes expres...

  10. Michelangelo in Parnaso. Scrittori a contatto con le Rime buonarrotiane: la ricezione critica, creativa e le traduzioni d’autore

    NARCIS (Netherlands)

    Cascio, Gandolfo

    2013-01-01

    Michelangelo Buonarroti (1475-1564) can be considered the embodiment of the Renaissance artist since he was an architect, a painter and a sculptor. Writing poetry was the fourth activity in which he engaged himself. This choice was not unusual among contemporaries: indeed also Raphael, Titian and

  11. Status Report on Speech Research. A Report on the Status and Progress of Studies on the Nature of Speech, Instrumentation for Its Investigation, and Practical Applications.

    Science.gov (United States)

    1983-09-30

    Raphael, & M. Valdovinos (Eds.), Language and cognition: Essays in honor of Arthur J. Bronstein. New York: Plenum. House, A. (1961). On vowel...9). For this we will find no better way than that of, say, James Joyce . In the meantime, there is science, and this calls for reliable data

  12. Browse Title Index

    African Journals Online (AJOL)

    Items 51 - 100 of 180 ... Raphael Wanyonyi Namaru. Vol 20 (2001), Estado e Políticas Arquivísticas, Abstract. Eugénio A Monteiro. Vol 33 (2014), Eternal memory or holy amnesia? Preservation of, and access to records and archives of African independent churches in South Africa, Abstract. Mpho Ngoepe, Patrick Ngulube.

  13. Browse Title Index

    African Journals Online (AJOL)

    Items 851 - 900 of 985 ... Iwebuke Charles Nkeki, Chukwuma Raphael Nwozo. Vol 11 (2007), The effect of ammonia intercalation on the superconducting properties of the alkali-metal doped fulleride, Abstract. F Matthew-Ojelabi. Vol 8 (2004), The effect of deformation on the sigma phase occurrence in some stainless steels ...

  14. Coenite seiklused ja Kim Ki-duki huumor / Merit Kask

    Index Scriptorium Estoniae

    Kask, Merit

    2007-01-01

    60-nda Cannes'i filmifestivali filme : Ethan ja Joel Coen'i "Pole maad vanadele meestele" ("No Country for Old Men" ; Ameerika Ühendriigid), Kim Ki-duki "Hingetõmme" ("Soom"/"Breath" ; Lõuna-Korea) ja Raphael Nadjari "Tehilim" (Prantsusmaa - Iisrael - Ameerika Ühendriigid)

  15. Prikljutshenija Koenov i jumor Kim Ki-duka / Merit Kask

    Index Scriptorium Estoniae

    Kask, Merit

    2007-01-01

    60-nda Cannes'i filmifestivali filme : Ethan ja Joel Coen'i "Pole maad vanadele meestele" ("No Country for Old Men" ; Ameerika Ühendriigid), Kim Ki-duki "Hingetõmme" ("Soom"/"Breath" ; Lõuna-Korea) ja Raphael Nadjari "Tehilim" (Prantsusmaa - Iisrael - Ameerika Ühendriigid)

  16. Clipboard: Neural coding of temporal information and its topography ...

    Indian Academy of Sciences (India)

    2010-11-09

    Nov 9, 2010 ... Thomas A Terleph1 Raphael Pinaud2. Department of Biology, Sacred Heart University, Fairfield, CT 06825, USA; Departments of Physiology, Geriatric Medicine and Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA ...

  17. Fra Bartolommeo

    DEFF Research Database (Denmark)

    Elen, Albert J.; Fischer, Chris

    In Museum Boijmans Van Beuningen, discover the masterpieces of Fra Bartolommeo (1473-1517), the Italian monk and artist from the famous monastery of San Marco in Florence. He, Leonardo da Vinci, Raphael and Michelangelo were the four most important artists of the High Renaissance. Paintings by Fra...

  18. Hinge peegel - keha / Margit Adorf

    Index Scriptorium Estoniae

    Adorf, Margit, 1974-

    2006-01-01

    10. PÖFFi filmidest: "Suust suhu" (režissöör Björn Runge; Rootsi - Taani 2005), "Transamerica" (režissöör Duncan Tucer; USA 2005), "Ükski keha pole täiuslik" (režissöör Raphael Sibilla; Prantsusmaa 2006)

  19. Clipboard: mGluR5 is a central regulator of synaptic function and ...

    Indian Academy of Sciences (India)

    2009-05-27

    May 27, 2009 ... Home; Journals; Journal of Biosciences; Volume 34; Issue 2. Clipboard: mGluR5 is a central regulator of synaptic function and plasticity in the developing mouse barrel cortex. Liisa A Tremere Raphael Pinaud. Volume 34 Issue 2 June 2009 pp 161-162 ...

  20. The African Union's diplomacy of the diaspora: Context, challenges ...

    African Journals Online (AJOL)

    Social remittances: Migration driven local level forms of cultural diffusion. International Migration Review, 32. Mwagiru, Makumi 2011. Diplomacy of the diaspora: Harnessing diasporas in Kenya's foreign policy. Diaspora Studies, 4. Ogom, Raphael 2009. The African Union, African diasporas and the quest for development: ...

  1. Clipboard: Single-neuron encoding of surprise in auditory processing

    Indian Academy of Sciences (India)

    Liisa A Tremere1 Raphael Pinaud1. Departments of Physiology, Geriatric Medicine and Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. Dates. Early published: 4 November 2010. Journal of Biosciences. Current Issue : Vol. 42, Issue 3. Current Issue

  2. Browse Title Index

    African Journals Online (AJOL)

    Items 51 - 100 of 102 ... Vol 3, No 1 (2006), Potential of waste tires as aggregates in concrete, Abstract. Raphael N Mutuku, Walter O Oyawa, Job N Mogeni. Vol 2, No 2 (2005), Properties of Low Strength Concrete made with Recycled Concrete Aggregate and Fly Ash, Abstract. R Kumar, D Manoharan. Vol 7, No 2 (2010), Quick ...

  3. Download this PDF file

    African Journals Online (AJOL)

    Chibuike

    hydrogen peroxide: The effects of reaction pH, buffer ion concentration, and redox mediation. Sylvia O. Malomo1*, Raphael I. Adeoye1, Lateef Babatunde1, Ibraheem A. Saheed1, Martin O. Iniaghe2, and. Femi J. Olorunniji1,3*. 1Department of Biochemistry, Faculty of Science, University of Ilorin, Ilorin, Nigeria; 2Department ...

  4. Browse Author Index

    African Journals Online (AJOL)

    Items 6051 - 6100 of 10679 ... Liance, Martine · Liang, Song · Liang, Tu Zheng · Lihana, R · Lihana, Raphael · Likwela, JL · Likwela, Joris Losimba · Limaiem, Faten · Limam, M · Limam, Manel · Limam, Sid'Ahmed Ould Mohamed · Limam, Sid'Ahmedould Mohamed · Lin, B · Ling, CW · Lingam, S · Lio, Massimo Magnano San

  5. Author Details

    African Journals Online (AJOL)

    Akanuoh, Raphael. Vol 30 (2015) - Articles Design and Construction of a Home Automation System Using a Smart Phone Abstract. ISSN: 1116-4336. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

  6. African Journal of Infectious Diseases - Vol 11, No 1 (2017)

    African Journals Online (AJOL)

    The prevalence of tuberculosis in cattle and their handlers in north Tongu, Volta region, Ghana · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Esther A. Amemor, S. O. Sackey, Nathaniel Yebuah, Raphael Deladem Folitse, Benjamin O Emikpe, E. Afari, F. Wurapa, ...

  7. Haematological and biochemical studies on the effect of diclofenac ...

    African Journals Online (AJOL)

    http://indexmedicus.afro.who.int. Haematological and biochemical studies on the effect of diclofenac sodium on. Wistar Rattus norvegicus. Orinya Agbaji ORINYA, Adeshina Yahaya ADENKOLA and Raphael John OGBE*. Department of Veterinary Physiology, Pharmacology and Biochemistry, College of Veterinary Medicine ...

  8. Ritueel van huiselijk geluk : een cultuurhistorische verkenning van de familiefilm

    NARCIS (Netherlands)

    Aasman, Susanna Ida

    2004-01-01

    Summary Rituals of domestic happiness ‘History is not the prerogative of the historian’, Raphael Samuel once wrote. Indeed, in the last century ‘do-it-yourself’ history became a common domestic activity. Film and photography offered people new opportunities to record their own history. These media

  9. Browse Title Index

    African Journals Online (AJOL)

    Items 1 - 50 of 174 ... AS Anzaku, S Mikah, SI Shuaibu. Vol 9, No 3 (2015), Case Report: Idiopathic calcific constrictive pericarditis an unsettling reality, Abstract PDF. SU Uguru, GA Amusa, JA Onuh, SC Raphael, PO Idoko, GS Tawe, BN Okeahialam. Vol 5, No 1 (2010), Case Report: Isolated Wassel Type II Preaxial Polydactyly ...

  10. 77 FR 16784 - E. & J. Gallo Winery; Filing of Color Additive Petition

    Science.gov (United States)

    2012-03-22

    ... additive regulations in 21 CFR 73.350 to provide for the safe use of mica-based pearlescent pigments prepared from titanium dioxide and mica as color additives in distilled spirits containing not less than 18... pearlescent pigments as color additives in certain distilled spirits. FOR FURTHER INFORMATION CONTACT: Raphael...

  11. Clipboard: Recovery from amblyopia in adults via decreased visual ...

    Indian Academy of Sciences (India)

    2008-04-28

    Apr 28, 2008 ... Home; Journals; Journal of Biosciences; Volume 33; Issue 2. Clipboard: Recovery from amblyopia in adults via decreased visual cortical inhibition caused by experience in an enriched environment. Liisa A Tremere Raphael Pinaud. Volume 33 Issue 2 June 2008 pp 157-158 ...

  12. Browse Title Index

    African Journals Online (AJOL)

    Items 1 - 24 of 24 ... Vol 2, No 1 (2012), Addressing the Difficulties of Learners in the Reading Class, Abstract. AA Wornyo. Vol 5 (2016), Assessing the ... Vol 5 (2016), Perceived Effects of Terrorism and Political Insurgency on the Recreational Habit of Nigerian Students, Abstract. Adeyemi Raphael Awopetu. Vol 4, No 1 (2014) ...

  13. Serum Level of Antioxidant Vitamins (Vitamin A, C and E) in ...

    African Journals Online (AJOL)

    JTEkanem

    2009-09-11

    Sep 11, 2009 ... Serum Level of Antioxidant Vitamins (Vitamin A, C and E) in Plasmodium falciparum. Malaria Infected Children in Owerri, Eastern Nigeria. Raphael C. EKEANYANWU. 1. *, Nkem ACHUKA. 1 and Benjamin U. AKPOILIH. 2. 1Biochemistry Unit, Department of Chemical Sciences, Novena University, Ogume, ...

  14. Shoptalk.

    Science.gov (United States)

    Meade, Jeff

    1991-01-01

    Describes innovative programs for teaching elementary school students. In Illinois, students learn about the artists Raphael, Michelangelo, Leonardo, and Donatello using the Teenage Mutant Ninja Turtles. An Oregon program prints student poetry and places it on cafeteria tables. In rural Texas, students learn about restaurant etiquette through play…

  15. Commentary: Visual object recognition: building invariant ...

    Indian Academy of Sciences (India)

    2008-11-13

    Nov 13, 2008 ... http://www.ias.ac.in/article/fulltext/jbsc/033/05/0639-0642. Keywords. Interferotemporal cortex; object invariance; object recognition; positional tolerance; saccadic eye movements. Author Affiliations. Duje Tadin1 Raphael Pinaud1. Department of Brain and Cognitive Sciences and Center for Visual Science, ...

  16. Jos Journal of Medicine - Vol 9, No 3 (2015)

    African Journals Online (AJOL)

    Case Report: Idiopathic calcific constrictive pericarditis an unsettling reality · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. SU Uguru, GA Amusa, JA Onuh, SC Raphael, PO Idoko, GS Tawe, BN Okeahialam ...

  17. Milk Consumption and Framingham Risk Score: Analysis of the Korea National Health and Nutrition Examination Survey Data (2008-2011).

    Science.gov (United States)

    Joo, Nam Seok; Yang, Sung Won; Park, Soo Jung; Choi, Sung Jin; Song, Byeng Chun; Yeum, Kyung Jin

    2016-01-01

    The benefit of milk intake remains controversial. The association between milk consumption and Framingham Risk Score (FRS) in a population consuming relatively low amounts of dairy products is undetermined. A total of 13736 adults (5718 male and 8018 female) aged 20-80 years from the Korea National Health and Nutrition Examination Survey (2008-2011) were divided into groups according to milk consumption (rarely, monthly, weekly, and daily) and compared according to FRS after relevant variable adjustments. The mean FRS in males and females were 6.53 and 5.74, respectively. Males who consumed milk daily (15.9%) had a significantly lower FRS than males having milk rarely (31.6%) or monthly (17.4%; p=0.007). Females who consumed milk daily (22.3%) also had significantly lower FRS than rarely (29.8%), monthly (13.8%), or weekly (34%; p=0.001) consumers. In particular, males ≥60 years old who consumed milk daily had a significantly lower FRS than males who consumed less milk (pmilk consumption groups when compared with the daily milk consumption group. Milk consumption was associated with a lower FRS in a low milk-consuming population. In particular, daily milk consumption in males over 60 years old may be beneficial for those at risk for cardiovascular disease.

  18. Relationship between Conventional Cardiovascular Disease Risk Assessment and Coronary Artery Calcification in Group Exposed to Inorganic Dusts

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Won Jeong; Park, So Young [Occupational Lung Diseases Institute, KCOMWEL, Ansan (Korea, Republic of)

    2013-03-15

    The purpose of this study is to determine the relationship between the coronary artery calcification (CAC) and the conventional cardiovascular disease risk assessment (CCDRA). This study included 101 subjects who were exposed to inorganic dusts and underwent CAC scoring by multidetector CT (MDCT), laboratory tests, and a standardized questionnaire for CCDRA, after being approved from the Institutional Review Board and providing informed consent. All subjects were divided as either non-calcified group (< 1, 55.4%) or calcified group ({>=} 1, 44.6%) from total CAC, and evaluated by CCDRA, such as Framingham risk score (FRS) and National Cholesterol Education Program (NCEP). Receiver operating characteristic (ROC) area of FRS was generated for predicting CAC risk using SPSS program (ver. 19.0, Chicago, IL, USA). Total CAC was significantly correlated with FRS (r = 0.283, p = 0.004). Crude odds ratio for CAC risk was 3.64 [95% confidence interval (CI) 1.39-9.52] in FRS {>=} 20%, and 2.87 (95% CI 1.24-6.65) in the high risk group of NCEP. Subjects with pneumoconiosis showed higher values of CAC (p 0.541) and FRS (p = 0.035) scores compared with subjects without pneumoconiosis. ROC area of FRS was 0.69 (95% CI 0.59-0.79) with a cutoff point of 13.5%. CAC measured MDCT is significantly correlated with FRS than other CCDRA.

  19. Selection bias: Examining the feasibility, utility, and participant receptivity to incorporating simulation into the general surgery residency selection process.

    Science.gov (United States)

    Gardner, Aimee K; Steffes, Christopher P; Nepomnayshy, Dmitry; Nicholas, Cate; Widmann, Warren D; Fitzgibbons, Shimae C; Dunkin, Brian J; Jones, Daniel B; Paige, John T

    2017-06-01

    Opportunities exist to revise the current residency selection process to capture desirable candidate competencies. We examined the extent to which components of the American College of Surgeons/Association for Surgical Education simulation-based medical student curriculum combined with a teamwork activity could be used as potential screening method. Students participated in a workshop consisting of training/evaluation of knot tying, suturing, airway management, gowning/gloving, and teamwork. Surveys were given to medical students (MS) and faculty/resident/staff (FRS) to examine their opinions about the residency screening process, the most critical competencies to assess, and the effectiveness of each station for candidate evaluation. Communication (FRS, 4.86 ± .35; MS, 4.93 ± .26), leadership (FRS, 4.41 ± .80; MS, 4.5 ± .76), judgment (FRS, 4.62 ± .74; MS, 4.67 ± .62), professionalism (FRS, 4.64 ± .73; MS, 5.00 ± .00), integrity (FRS, 4.71 ± .78; MS, 4.87 ± .35), and grit/resilience (FRS, 4.71 ± .78; MS, 4.53 ± .74) were considered most valuable for candidate screening. The simulation-based curriculum for evaluation of residency candidates was rated lowest by both groups. Open response comments indicated positive perceptions of this process. Employing simulation to assess candidates may be most beneficial for examining nontechnical attributes. Future work should continue to explore this area. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. Analysis of integrated multiple 'omics' datasets reveals the mechanisms of initiation and determination in the formation of tuberous roots in Rehmannia glutinosa.

    Science.gov (United States)

    Li, Mingjie; Yang, Yanhui; Li, Xinyu; Gu, Li; Wang, Fengji; Feng, Fajie; Tian, Yunhe; Wang, Fengqing; Wang, Xiaoran; Lin, Wenxiong; Chen, Xinjian; Zhang, Zhongyi

    2015-09-01

    All tuberous roots in Rehmannia glutinosa originate from the expansion of fibrous roots (FRs), but not all FRs can successfully transform into tuberous roots. This study identified differentially expressed genes and proteins associated with the expansion of FRs, by comparing the tuberous root at expansion stages (initiated tuberous root, ITRs) and FRs at the seedling stage (initiated FRs, IFRs). The role of miRNAs in the expansion of FRs was also explored using the sRNA transcriptome and degradome to identify miRNAs and their target genes that were differentially expressed between ITRs and FRs at the mature stage (unexpanded FRs, UFRs, which are unable to expand into ITRs). A total of 6032 genes and 450 proteins were differentially expressed between ITRs and IFRs. Integrated analyses of these data revealed several genes and proteins involved in light signalling, hormone response, and signal transduction that might participate in the induction of tuberous root formation. Several genes related to cell division and cell wall metabolism were involved in initiating the expansion of IFRs. Of 135 miRNAs differentially expressed between ITRs and UFRs, there were 27 miRNAs whose targets were specifically identified in the degradome. Analysis of target genes showed that several miRNAs specifically expressed in UFRs were involved in the degradation of key genes required for the formation of tuberous roots. As far as could be ascertained, this is the first time that the miRNAs that control the transition of FRs to tuberous roots in R. glutinosa have been identified. This comprehensive analysis of 'omics' data sheds new light on the mechanisms involved in the regulation of tuberous roots formation. © The Author 2015. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  1. Dipolarization fronts as Earthward Propagating Flux Ropes: A Three-dimensional Global Hybrid Simulation

    Science.gov (United States)

    Lu, Q.; Lu, S.; Lin, Y.; Wang, X.

    2016-12-01

    Dipolarization fronts (DFs) as earthward propagating flux ropes (FRs) in the Earth's magnetotailare presented and investigated with a three-dimensional (3-D) global hybrid simulation for the first time. In thesimulation, several small-scale earthward propagating FRs are found to be formed by multiple X line reconnectionin the near tail. During their earthward propagation, the magnetic field Bz of the FRs becomes highly asymmetricdue to the imbalance of the reconnection rates between the multiple X lines. At the later stage, when the FRsapproach the near-Earth dipole-like region, the antireconnection between the southward/negative Bz ofthe FRs and the northward geomagnetic field leads to the erosion of the southward magnetic flux of theFRs, which further aggravates the Bz asymmetry. Eventually, the FRs merge into the near-Earth regionthrough the antireconnection. These earthward propagating FRs can fully reproduce the observationalfeatures of the DFs, e.g., a sharp enhancement of Bz preceded by a smaller amplitude Bz dip, an earthwardflow enhancement, the presence of the electric field components in the normal and dawn-dusk directions,and ion energization. Our results show that the earthward propagating FRs can be used to explain the DFsobserved in the magnetotail. The thickness of the DFs is on the order of several ion inertial lengths, and theelectric field normal to the front is found to be dominated by the Hall physics. During the earthward propagationfrom the near-tail to the near-Earth region, the speed of the FR/DFs increases from 150km/s to 1000 km/s. TheFR/DFs can be tilted in the GSM (x, y) plane with respect to the y (dawn-dusk) axis and only extend several Earthradii in this direction. Moreover, the structure and evolution of the FRs/DFs are nonuniform in the dawn-duskdirection, which indicates that the DFs are essentially 3-D.

  2. Comparison of coronary artery calcification scores and National Cholesterol Education program guidelines for coronary heart disease risk assessment and treatment paradigms in individuals with chronic traumatic spinal cord injury.

    Science.gov (United States)

    Lieberman, Jesse A; Hammond, Flora M; Barringer, Thomas A; Norton, H J; Goff, David C; Bockenek, William L; Scelza, William M

    2011-01-01

    To investigate the risk of coronary heart disease (CHD) in individuals with spinal cord injury (SCI) according to the National Cholesterol Educational Program (NCEP) guidelines and CT coronary artery calcium scores (CCS). Cross-sectional study of consecutive sample of males with SCI presenting to a single site for CHD risk assessment. Males age 45-70 with traumatic SCI (American Spinal Injury Association (ASIA) A, B, and C) injured for at least 10 years with no prior history of clinical CHD. Medical history, blood-pressure, and fasting lipid panel were used to calculate risk for CHD with the use of the Framingham risk score (FRS). Risk and treatment eligibility status was assessed based on NCEP/FRS recommendations and by presence and amount of CCS. Percent agreement (PA) and kappa were calculated between the two algorithms. Spearman correlations were calculated between CCS and FRS and individual risk factors. A total of 38 men were assessed; 18 (47.4%) had CCS > 0. The PA between NCEP/FRS assessment and CCS was 18% with a kappa of -0.03. 11 (28.9%) had CCS > 100 or >75th percentile for their age, sex, and race, which might qualify them for lipid-lowering treatment. Only 26 were placed into the same treatment category by NCEP/FRS and CCS, for a PA of 68% with a kappa of 0.35. In all, 20 (52.6%) were eligible for lipid-lowering treatment by either NCEP/FRS (n=9) or CCS (n = 11). Seven subjects were above the treatment threshold based on CCS, but not NCEP/FRS and five subjects were above the NCEP/FRS threshold, but not CCS. Just four subjects were eligible by both algorithms. CCS only correlated with FRS (r = 0.508, P = 0.001) and age (r = 0.679, P < 0.001).

  3. Faraday rotation spectroscopy of nitrogen dioxide based on a widely tunable external cavity quantum cascade laser

    Science.gov (United States)

    Zaugg, Christian A.; Lewicki, Rafal; Day, Tim; Curl, Robert F.; Tittel, Frank K.

    2011-01-01

    Faraday Rotation Spectroscopy (FRS) is a technique for the sensitive and selective detection of paramagnetic molecules or radicals such as NO, NO2, O2 or OH-. Moreover FRS is suitable for atmospheric measurements due to the insensitivity to non-paramagnetic interfering molecules such as H2O and CO2. Experimental results of an FRS sensor for the NO2detection employing an external-cavity quantum cascade laser (EC-QCL) are reported. The CW EC-QCL exhibits modehop free (MHF) tuning between 1600 cm-1 and 1650 cm-1. This allows targeting the optimum 441constant (TC).

  4. Development of test systems for characterizing emissions from spray polyurethane foam insulation (SPFI)

    Science.gov (United States)

    The relationship between onsite manufacture of spray polyurethane foam insulation (SPFI) and potential exposures to diisocyanates, amines, flame retardants (FRs), blowing agents, aldehydes and other organic compounds that may be emitted from SPFI is not well understood. EPA is de...

  5. EPA Linked Open Data (Collection)

    Data.gov (United States)

    U.S. Environmental Protection Agency — This is a collection item referencing the following EPA Linked Data resources: - EPA Facility Registry Service (FRS) - EPA Substance Registry Service (SRS) -...

  6. Synthesis and characterization of folate-poly(ethylene glycol ...

    African Journals Online (AJOL)

    Jane

    2011-07-04

    Jul 4, 2011 ... was comparable to that of adenovirus-mediated luciferase transduction (1 × 109 pfu) in melanoma- ... FRs specificity in vitro and in vivo, may be useful in gene therapy. ... vectors, poly(ethylene imine) (PEI) was commonly.

  7. Cardiovascular risk prediction in chronic kidney disease patients

    Directory of Open Access Journals (Sweden)

    Santiago Cedeño Mora

    2017-05-01

    Conclusion: The cardiovascular risk scores (FRS-CVD and ASCVD [AHA/ACC 2013] can estimate the probability of atherosclerotic cardiovascular events in patients with CKD regardless of renal function, albuminuria and previous cardiovascular events.

  8. 75 FR 33281 - National Institute on Disability and Rehabilitation Research (NIDRR)-Disability and...

    Science.gov (United States)

    2010-06-11

    ... (FRS), toll free, at 1-800-877-8339. SUPPLEMENTARY INFORMATION: This notice of final priorities (NFP... between the NPP and this NFP as discussed in the following section. Public Comment: In response to our...

  9. Assessing the effects of seawater temperature and pH on the bioaccumulation of emerging chemical contaminants in marine bivalves

    NARCIS (Netherlands)

    Maulvault, Ana Luísa; Camacho, Carolina; Barbosa, Vera; Alves, Ricardo; Anacleto, Patrícia; Fogaça, Fabiola; Kwadijk, Christiaan; Kotterman, Michiel; Cunha, Sara C.; Fernandes, José O.; Rasmussen, Rie R.; Sloth, Jens J.; Aznar-Alemany, Òscar; Eljarrat, Ethel; Barceló, Damià; Marques, António

    2018-01-01

    Emerging chemical contaminants [e.g. toxic metals speciation, flame retardants (FRs) and perfluorinated compounds (PFCs), among others], that have not been historically recognized as pollutants nor their toxicological hazards, are increasingly more present in the marine environment. Furthermore, the

  10. Ramaswamy, Dr Sriram Rajagopal

    Indian Academy of Sciences (India)

    Chicago), FNASc, FNA, FRS. Date of birth: 10 November 1957. Specialization: Condensed Matter Physics, Non-Equilibrium Statistical Physics and Physics of Biological Systems Address: Department of Physics, Indian Institute of Science, Bengaluru ...

  11. Disease: H00993 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available he central nervous system have been reported such as partial agenesis of the corpus callosum, hypoplastic fr...S, Philip N Microcephalic osteodysplastic primordial dwarfism Taybi-Linder type: report of four cases and re

  12. Fungal rhino sinusitisin in tehran, iran

    NARCIS (Netherlands)

    Nazeri, M.; Hashemi, S.J.; Ardehali, M.; Rezaei, S.; Seyedmousavi, S.; Zareei, M.; Hosseinjani, E.

    2015-01-01

    BACKGROUND: Fungal rhino sinusitis (FRS) is an important infection of para nasal sinuses, which encompasses two main categories; invasive and noninvasive forms according to histopathological findings. Aspergillus spp are the most common species isolated from noninvasive form, while Mucorales are

  13. Breakdown voltage at the electric terminals of GCFR-core flow test loop fuel rod simulators in helium and air

    Energy Technology Data Exchange (ETDEWEB)

    Huntley, W.R.; Conley, T.B.

    1979-12-01

    Tests were performed to determine the ac and dc breakdown voltage at the terminal ends of a fuel rod simulator (FRS) in helium and air atmospheres. The tests were performed at low pressures (1 to 2 atm) and at temperatures from 20 to 350/sup 0/C (68 to 660/sup 0/F). The area of concern was the 0.64-mm (0.025-in.) gap between the coaxial conductor of the FRS and the sheaths of the four internal thermocouples as they exit the FRS. The tests were prformed to ensure a sufficient safety margin during Core Flow Test Loop (CFTL) operations that require potentials up to 350 V ac at the FRS terminals. The primary conclusion from the test results is that the CFTL cannot be operated safely if the terminal ends of the FRSs are surrounded by a helium atmosphere but can be operated safely in air.

  14. 75 FR 32169 - Comprehensive Centers Program

    Science.gov (United States)

    2010-06-07

    ... use a telecommunications device for the deaf (TDD), call the Federal Relay Service (FRS), toll free... be continued without interruption. Discussion: We note the importance of the support of the...

  15. How Can the Deactivation of the Marine Prowler Community Best Serve the Marine Corps?

    Science.gov (United States)

    2010-03-01

    Electronic Counter Measure Officers ( ECMO ) transitioning to new communities. Before the Prowler community deactivation begins it will undergo some...Prowler squadron consists of 180 Marines. Eight are pilots, twenty are Electronic Counter Measure Officers ( ECMO ), twenty seven are Sta:ffNon-Commissioned...three operational squadrons and an FRS. The FRS activation would be used to facilitate the production of any remaining pilots and ECMOs needed to

  16. Medical Robotic and Telesurgical Simulation and Education Research

    Science.gov (United States)

    2014-09-01

    rubber resins . Since we were still 11 experimenting with the placement of the exercises, the first 3D printed dome structure was created with a...passed through low fidelity prototypes created with inexpensive materials to high fidelity prototypes with resin products, using different silicone...Advanced Skills Society Advanced Individual Procedures FRS for Specialties (“Sweet Tree ”) 30 FRS FRGS FRUS FRcoloS FRcardioS FRGS Advanced FRUS

  17. Combination of high ankle-brachial index and hard coronary heart disease Framingham Risk Score in predicting the risk of ischemic stroke in general population.

    Directory of Open Access Journals (Sweden)

    Yinyin Zhang

    Full Text Available Our previous study showed that the patients with more metabolic risk factors had higher risk of high ankle-brachial index (ABI, but the relationship between high ABI and the risk of severe cardiovascular and cerebrovascular diseases is still under debate. This study aims to evaluate this association in the general population. 1486 subjects of South China were recruited in the study. 61 subjects were defined as high ABI group (ABI≥1.3 and 65 subjects were randomly selected as normal ABI group (0.9FRS were compared between two groups. The results showed that the 10-year HCHD FRS of high ABI group was significantly higher than normal ABI group (7.87 ± 6.11 vs. 3.98 ± 2.90%, P<0.001. There was a positive correlation between ABI value and HCHD FRS in overweight participants (R = 0.576, P<0.01. The prevalence of ischemic stroke was higher in high ABI group than normal ABI group (21.3% vs. 6.2%, P<0.05, and it was higher in participants with HCHD FRS ≥ 6% than those with HCHD FRS<6% (19.1% vs. 6.9%, P<0.05. Moreover, the prevalence of ischemic stroke was higher in participants with high ABI and HCHD FRS ≥ 6% than those with normal ABI and HCHD FRS<6% (26.7% vs. 4.1%, P<0.05. BMI, hypertension, hsCRP and smoking were proved to be the independent factors and effective predictors for high ABI (P<0.05. In conclusion, high ABI combined with high HCHD FRS should be a potential predictor of ischemic stroke in the general population of South China.

  18. The diagnostic status of first-rank symptoms

    DEFF Research Database (Denmark)

    Nordgaard, Julie; Arnfred, Sidse Marie; Handest, P.

    2008-01-01

    In the International Statistical Classification of Diseases, Tenth Revision(ICD-10) and Diagnostic and Statistical Manual of Mental Disorder, Third and Fourth Edition(DSM-III-IV), the presence of one of Schneider "first-rank symptoms" (FRS) is symptomatically sufficient for the schizophrenia...... diagnosis. Yet, it has been claimed that FRS may also be found in the nonschizophrenic conditions, and therefore, they are not specific or diagnostic for schizophrenia. This review was made to clarify the issue of diagnostic specificity....

  19. Prediction of Cardiovascular Disease Risk among Low-Income Urban Dwellers in Metropolitan Kuala Lumpur, Malaysia

    OpenAIRE

    Tin Tin Su; Mohammadreza Amiri; Farizah Mohd Hairi; Nithiah Thangiah; Awang Bulgiba; Hazreen Abdul Majid

    2015-01-01

    We aimed to predict the ten-year cardiovascular disease (CVD) risk among low-income urban dwellers of metropolitan Malaysia. Participants were selected from a cross-sectional survey conducted in Kuala Lumpur. To assess the 10-year CVD risk, we employed the Framingham risk scoring (FRS) models. Significant determinants of the ten-year CVD risk were identified using General Linear Model (GLM). Altogether 882 adults (≥30 years old with no CVD history) were randomly selected. The classic FRS mode...

  20. Development of plastic disks containing flame retardants for elucidating changes in their concentrations due to simulated weathering and the application of these disks to weathering tests.

    Science.gov (United States)

    Hanari, Nobuyasu; Otake, Takamitsu; Itoh, Nobuyasu; Wada, Ayaka; Ohata, Masaki

    2017-02-01

    Flame retardants (FRs) are useful because they can prevent combustion and delay the spread of fire after the ignition on commercial products containing plastics. However, such commercial products could be a primary source of environmental contamination with FRs. Plastic disks containing FRs were prepared to elucidate changes in the concentrations of the FRs after weathering tests. Acrylonitrile-butadiene-styrene (ABS) and polycarbonate (PC) resin were separately kneaded with a combination of three organic FRs [Dechlorane plus (DP), tetrabromobisphenol A (TBBPA), and triphenyl phosphate (TPhP)] and one inorganic FR [antimony trioxide (Sb2O3)]. The concentrations of TBBPA/TPhP and DP/Sb2O3 in the final preparations were respectively 1000 and 500 mg/kg in compliance with the RoHS directive on organobromine FR. The concentrations of elements in the final preparations were 300 mg/kg for chlorine, 600 mg/kg for bromine, 100 mg/kg for phosphorus, and 400 mg/kg for antimony, respectively. The analytical concentrations (three FRs and four elements) were consistent with the expected concentrations (maximum difference -9.5% in the PC disks). The FRs and elements in the disks were sufficiently homogenous (maximum inhomogeneity 4.3% in the PC disks). The prepared disks were subjected to weathering tests; the concentrations of TBBPA in the disks decreased significantly (30 to 40%) whereas the concentrations of the elements did not change under the condition of this study. On the other hand, there were no drastic differences on relationships of FRs and elements such as DP/chlorine and TPhP/phosphorus.

  1. SNF fuel retrieval sub project safety analysis document

    Energy Technology Data Exchange (ETDEWEB)

    BERGMANN, D.W.

    1999-02-24

    This safety analysis is for the SNF Fuel Retrieval (FRS) Sub Project. The FRS equipment will be added to K West and K East Basins to facilitate retrieval, cleaning and repackaging the spent nuclear fuel into Multi-Canister Overpack baskets. The document includes a hazard evaluation, identifies bounding accidents, documents analyses of the accidents and establishes safety class or safety significant equipment to mitigate accidents as needed.

  2. Relationship between framingham risk score and coronary artery calcium score in asymptomatic Korean individuals

    Energy Technology Data Exchange (ETDEWEB)

    Heo, So Young; Park, Noh Hyuck; Park, Chan Sub; Seong, Su Ok [Dept. of Radiology, Myongji Hospital, Seonam University College of Medicine, Goyang (Korea, Republic of)

    2016-02-15

    We explored the association between Framingham risk score (FRS) and coronary artery calcium score (CACS) in asymptomatic Korean individuals. We retrospectively analyzed 2216 participants who underwent routine health screening and CACS using the 64-slice multidetector computed tomography between January 2010 and June 2014. Relationship between CACS and FRS, and factors associated with discrepancy between CACS and FRS were analyzed. CACS and FRS were positively correlated (p < 0.0001). However, in 3.7% of participants with low coronary event risk and high CACS, age, male gender, smoker, hypertension, total cholesterol, diabetes mellitus, and body mass index (BMI; ≥ 35) were associated with the discrepancy. In the diagnostic prediction model for discrepancy, the receiver operating characteristic curve including factors associated with FRS, diastolic blood pressure (≥ 75 mm Hg), diabetes mellitus, and BMI (≥ 35) showed that the area under the curve was 0.854 (95% confidence interval, 0.819–0.890), indicating good sensitivity. Diabetes mellitus or obesity (BMI ≥ 35) compensate for the weakness of FRS and may be potential indicators for application of CACS in asymptomatic Koreans with low coronary event risk.

  3. Framingham risk score for estimation of 10-years of cardiovascular diseases risk in patients with metabolic syndrome.

    Science.gov (United States)

    Jahangiry, Leila; Farhangi, Mahdieh Abbasalizad; Rezaei, Fatemeh

    2017-11-13

    There are a few studies evaluating the predictive value of Framingham risk score (FRS) for cardiovascular disease (CVD) risk assessment in patients with metabolic syndrome in Iran. Because of the emerging high prevalence of CVD among Iranian population, it is important to predict its risk among populations with potential predictive tools. Therefore, the aim of the current study is to evaluate the FRS and its determinants in patients with metabolic syndrome. In the current cross-sectional study, 160 patients with metabolic syndrome diagnosed according to the National Cholesterol Education Adult Treatment Panel (ATP) III criteria were enrolled. The FRS was calculated using a computer program by a previously suggested algorithm. Totally, 77.5, 16.3, and 6.3% of patients with metabolic syndrome were at low, intermediate, and high risk of CVD according to FRS categorization. The highest prevalence of all of metabolic syndrome components were in low CVD risk according to the FRS grouping (P metabolic syndrome and different FRS categorization among patients with metabolic syndrome were identified. High SBP and FSG were associated with meaningfully increased risk of CVD compared with other parameters. The study is not a trial; the registration number is not applicable.

  4. Filament formation associated with spirochetal infection: a comparative approach to Morgellons disease

    OpenAIRE

    Stricker, Raphael; Middelveen,Marianne

    2011-01-01

    Marianne J Middelveen, Raphael B StrickerInternational Lyme and Associated Diseases Society, Bethesda, MD, USAAbstract: Bovine digital dermatitis is an emerging infectious disease that causes lameness, decreased milk production, and weight loss in livestock. Proliferative stages of bovine digital dermatitis demonstrate keratin filament formation in skin above the hooves in affected animals. The multifactorial etiology of digital dermatitis is not well understood, but spirochetes and other coi...

  5. Morgellons disease: a filamentous borrelial dermatitis

    OpenAIRE

    Middelveen, Marianne J; Stricker, Raphael B

    2016-01-01

    Marianne J Middelveen, Raphael B Stricker International Lyme and Associated Diseases Society, Bethesda, MD, USA Abstract: Morgellons disease (MD) is a dermopathy characterized by multicolored filaments that lie under, are embedded in, or project from skin. Although MD was initially considered to be a delusional disorder, recent studies have demonstrated that the dermopathy is associated with tickborne infection, that the filaments are composed of keratin and collagen, and that they resu...

  6. Characterization and evolution of dermal filaments from patients with Morgellons disease

    OpenAIRE

    Stricker, Raphael; Middelveen,Marianne; Mayne,Peter; Kahn,

    2013-01-01

    Marianne J Middelveen,1 Peter J Mayne,1 Douglas G Kahn,2 Raphael B Stricker11International Lyme and Associated Diseases Society, Bethesda, MD, USA; 2Department of Pathology, Olive View–UCLA Medical Center, Sylmar, CA, USAAbstract: Morgellons disease is an emerging skin disease characterized by formation of dermal filaments associated with multisystemic symptoms and tick-borne illness. Some clinicians hypothesize that these often colorful dermal filaments are textile fibers, either s...

  7. Morgellons disease: Analysis of a population with clinically confirmed microscopic subcutaneous fibers of unknown etiology

    OpenAIRE

    Virginia R Savely; Raphael B Stricker

    2010-01-01

    Virginia R Savely1, Raphael B Stricker21TBD Medical Associates, San Francisco, CA, USA; 2International Lyme and Associated Diseases Society, Bethesda, MD, USABackground: Morgellons disease is a controversial illness in which patients complain of stinging, burning, and biting sensations under the skin. Unusual subcutaneous fibers are the unique objective finding. The etiology of Morgellons disease is unknown, and diagnostic criteria have yet to be established. Our goal was to identify prevalen...

  8. Reference: 740 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available 740 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u18318687i Higgins James...s not required for synapsis. 1 28-39 18318687 2008 Jul The Plant journal Franklin F Chris H|Higgins James D|Jones Gareth H|Mercier Raphael|Pugh Alice G|Vignard Julien

  9. 2016 WCRP CliC Annual Report

    OpenAIRE

    Hislop, lawrence; Hamon, Gwénaëlle

    2017-01-01

    The 2016 Annual Report of the World Climate Research Programme (WCRP)'s Climate and Cryosphere (CliC) Project gives an overview of our activities in 2016 and includes contributions from Greg Flato, Gerhard Krinner, James Renwick, Mike Sparrow, Sophie Nowicki, Eric Larour, Tony Payne, David and Denise Holland, Chris Derksen, Regine Hock, Ben Marzeion, Alexandra Jahn, Dirk Notz, Christina Schaedel, Ted Schuur, Don Perovich, Marilyn Raphael, Jenny Hutchings, Steve Ackley, Allen Pope, Penny Wagne...

  10. Mycoflora and production of wine from fruits of soursop (Annona Muricata L.)

    OpenAIRE

    Raphael N Okigbo; Omokaro Obire

    2008-01-01

    Raphael N Okigbo1, Omokaro Obire21Department of Botany, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria; 2Department of Applied and Environmental Biology, Rivers State University of Science and Technology, Port Harcourt, NigeriaAbstract: An investigation was conducted on the mycoflora associated with the different parts of fresh and rotten fruits of soursop (Annona muricata L.) and the potential of using both indigenous yeast flora and commercial yeast extract for wine production. Iso...

  11. Historical Group Debriefing Following Combat

    Science.gov (United States)

    1991-12-01

    urgent appeal for specialized care , indeed, as Baverly Raphael says, for every comforting human response" capable of reducing the suffering ihvolved...forms of debriefing might have a substantial psycological impact on participants They are part of the institution’s culture, acquire a quality of...Cohen. R. E. and Ahearn, F. L. (1980) Handbook of Mental Health Care for Disaster Victims. Johns Hopkins University Press, Baltimore, MD. Cohen. R.C

  12. Averroës in The school of Athens: a Renaissance man and his contribution to Western thought and neuroscience.

    Science.gov (United States)

    Belen, Deniz; Bolay, Hayrunnisa

    2009-02-01

    The European Renaissance was a revolutionary movement in human history. In this era of the rebirth of humanity, a great number of valuable artworks were created. One of these masterpieces is the magnificent wall painting The School of Athens, by Raphael, which is also known as a "visualization of knowledge." Raphael depicted almost all ancient Greek philosophers in this fresco. The painting displays one noticeable figure among the scholars: the philosopher/scientist Averroës from Andalusia. Western thought was greatly influenced by Averroës' philosophy. Averroës was as extraordinary a physician as he was a philosopher. His medical works presented novel concepts such as the discovery of the photoreceptor function of the retina, describing symptoms and signs of Parkinson's disease, and proposing a cardiac/vascular origin of cerebral stroke. In this article, we aimed to introduce Averroës' works and his contribution to neuroscience in the context of art, framed particularly with Raphael's masterwork The School of Athens.

  13. Association between global leukocyte DNA methylation and cardiovascular risk in postmenopausal women.

    Science.gov (United States)

    Ramos, Ramon Bossardi; Fabris, Vitor; Lecke, Sheila Bunecker; Maturana, Maria Augusta; Spritzer, Poli Mara

    2016-10-10

    Genetic studies to date have not provided satisfactory evidence regarding risk polymorphisms for cardiovascular disease (CVD). Conversely, epigenetic mechanisms, including DNA methylation, seem to influence the risk of CVD and related conditions. Because postmenopausal women experience an increase in CVD, we set out to determine whether global DNA methylation was associated with cardiovascular risk in this population. In this cross sectional study carried out in a university hospital, 90 postmenopausal women without prior CVD diagnosis (55.5 ± 4.9 years, 5.8 [3.0-10.0] years since menopause) were enrolled. DNA was extracted from peripheral leukocytes and global DNA methylation levels were obtained with an ELISA kit. Cardiovascular risk was estimated by the Framingham General Cardiovascular Risk Score (10-year risk) (FRS). Clinical and laboratory variables were assessed. Patients were stratified into two CVD risk groups: low (FRS: <10 %, n = 69) and intermediate/high risk (FRS ≥10 %, n = 21). Age, time since menopause, blood pressure, total cholesterol, and LDL-c levels were higher in FRS ≥10 % group vs. FRS <10 % group. BMI, triglycerides, HDL-c, HOMA-IR, glucose and hsC-reactive protein levels were similar in the two groups. Global DNA methylation (% 5mC) in the overall sample was 26.5 % (23.6-36.9). The FRS ≥10 % group presented lower global methylation levels compared with the FRS <10 % group: 23.9 % (20.6-29.1) vs. 28.8 % (24.3-39.6), p = 0.02. This analysis remained significant even after adjustment for time since menopause (p = 0.02). Our results indicate that lower global DNA methylation is associated with higher cardiovascular risk in postmenopausal women.

  14. Framingham risk score and alternatives for prediction of coronary heart disease in older adults.

    Directory of Open Access Journals (Sweden)

    Nicolas Rodondi

    Full Text Available Guidelines for the prevention of coronary heart disease (CHD recommend use of Framingham-based risk scores that were developed in white middle-aged populations. It remains unclear whether and how CHD risk prediction might be improved among older adults. We aimed to compare the prognostic performance of the Framingham risk score (FRS, directly and after recalibration, with refit functions derived from the present cohort, as well as to assess the utility of adding other routinely available risk parameters to FRS.Among 2193 black and white older adults (mean age, 73.5 years without pre-existing cardiovascular disease from the Health ABC cohort, we examined adjudicated CHD events, defined as incident myocardial infarction, CHD death, and hospitalization for angina or coronary revascularization.During 8-year follow-up, 351 participants experienced CHD events. The FRS poorly discriminated between persons who experienced CHD events vs. not (C-index: 0.577 in women; 0.583 in men and underestimated absolute risk prediction by 51% in women and 8% in men. Recalibration of the FRS improved absolute risk prediction, particulary for women. For both genders, refitting these functions substantially improved absolute risk prediction, with similar discrimination to the FRS. Results did not differ between whites and blacks. The addition of lifestyle variables, waist circumference and creatinine did not improve risk prediction beyond risk factors of the FRS.The FRS underestimates CHD risk in older adults, particularly in women, although traditional risk factors remain the best predictors of CHD. Re-estimated risk functions using these factors improve accurate estimation of absolute risk.

  15. Evaluation of Gastrointestinal Leakage in Multiple Enteric Inflammation Models in Chickens

    Science.gov (United States)

    Kuttappan, Vivek A.; Vicuña, Eduardo A.; Latorre, Juan D.; Wolfenden, Amanda D.; Téllez, Guillermo I.; Hargis, Billy M.; Bielke, Lisa R.

    2015-01-01

    Enteric inflammation models can help researchers’ study methods to improve health and performance and evaluate various growth promoters and dietary formulations targeted to improve performance in poultry. Oral administration of fluorescein isothiocyanate-dextran (FITC-d; 3–5 kDa) and its pericellular mucosal epithelial leakage are an established marker to evaluate enteric inflammation in multiple species. The present study evaluated different methods to induce gut inflammation in poultry based on FITC-d leakage. Four independent experiments were completed with different inflammation treatment groups, and serum FITC-d and/or retention of FITC-d in GI tract were determined. In experiment 1 (n = 10 birds/treatment, broilers, processed at 14 days), groups included control (CON), dextran sodium sulfate (DSS; drinking water at 0.75%) and feed restriction (FRS; 24 h before processing). Experiment 2 (n = 14 birds/treatment, leghorns, processed at 7 days) included CON, DSS, FRS, and rye-based diet (RBD). In experiments 3 and 4 (n = 15 birds/treatment, broilers, processed at 7 days), groups were CON, DSS, high fat diet (HFD), FRS, and RBD. In all experiments, FRS and RBD treatments showed significantly higher serum FITC-d levels compared to the respective CON. This indicates that FRS and RBD results in disruption of the intact barrier of the gastrointestinal tract (GIT), resulting in increased gut permeability. DSS and HFD groups showed elevation of serum FITC-d levels although the magnitude of difference from respective CON was inconsistent between experiments. FRS was the only treatment which consistently showed elevated retention of FITC-d in GIT in all experiments. The results from present studies showed that FRS and RBD, based on serum FITC-d levels, can be robust models to induce gut leakage in birds in different age and species/strains. PMID:26697435

  16. Evaluation of gastrointestinal leakage in multiple enteric inflammation models in chickens

    Directory of Open Access Journals (Sweden)

    Vivek A. Kuttappan

    2015-12-01

    Full Text Available Enteric inflammation models can help researchers study methods to improve health and performance plus evaluate various growth promoters and dietary formulations targeted to improve performance in poultry. Oral administration of fluorescein isothiocyanate dextran (FITC-d; 3-5 kDa and its pericellular mucosal epithelial leakage is an established marker to evaluate enteric inflammation in multiple species. The present study evaluated different methods to induce gut inflammation in poultry based on FITC-d leakage. Four independent experiments were completed with different inflammation treatment groups; serum FITC-d and/or retention of FITC-d in GI tract was/were determined. In experiment 1 (n=10 birds/treatment; broilers; processed at 14d, groups included control (CON, Dextran sodium sulfate (DSS; drinking water at 0.75% and feed restriction (FRS; 24h before processing. Experiment 2 (n=14birds/treatment; leghorns; processed at 7d included CON, DSS, FRS, and rye based diet (RBD. In experiments 3 and 4 (n=15 birds/treatment; broilers; processed at 7d, groups were CON, DSS, high fat diet (HFD, FRS, and RBD. In all experiments, FRS and RBD treatments showed significantly higher serum FITC-d levels compared to the respective CON. This indicates that FRS and RBD results in disruption of the intact barrier of the GIT, resulting in increased gut permeability. DSS and HFD groups showed elevation of serum FITC-d levels although the magnitude of difference from respective CON were inconsistent between experiments. FRS was the only treatment which consistently showed elevated retention of FITC-d in GIT in all experiments. The results from present studies showed that FRS and RBD, based on serum FITC-d levels, can be robust models to induce gut leakage in birds in different age and species/strains.

  17. Shall we really say goodbye to first rank symptoms?

    Science.gov (United States)

    Heinz, A; Voss, M; Lawrie, S M; Mishara, A; Bauer, M; Gallinat, J; Juckel, G; Lang, U; Rapp, M; Falkai, P; Strik, W; Krystal, J; Abi-Dargham, A; Galderisi, S

    2016-09-01

    First rank symptoms (FRS) of schizophrenia have been used for decades for diagnostic purposes. In the new version of the DSM-5, the American Psychiatric Association (APA) has abolished any further reference to FRS of schizophrenia and treats them like any other "criterion A" symptom (e.g. any kind of hallucination or delusion) with regard to their diagnostic implication. The ICD-10 is currently under revision and may follow suit. In this review, we discuss central points of criticism that are directed against the continuous use of first rank symptoms (FRS) to diagnose schizophrenia. We describe the specific circumstances in which Schneider articulated his approach to schizophrenia diagnosis and discuss the relevance of his approach today. Further, we discuss anthropological and phenomenological aspects of FRS and highlight the importance of self-disorder (as part of FRS) for the diagnosis of schizophrenia. Finally, we will conclude by suggesting that the theory and rationale behind the definition of FRS is still important for psychopathological as well as neurobiological approaches today. Results of a pivotal meta-analysis and other studies show relatively poor sensitivity, yet relatively high specificity for FRS as diagnostic marker for schizophrenia. Several methodological issues impede a systematic assessment of the usefulness of FRS in the diagnosis of schizophrenia. However, there is good evidence that FRS may still be useful to differentiate schizophrenia from somatic causes of psychotic states. This may be particularly important in countries or situations with little access to other diagnostic tests. FRS may thus still represent a useful aid for clinicians in the diagnostic process. In conclusion, we suggest to continue a tradition of careful clinical observation and fine-grained psychopathological assessment, including a focus on symptoms regarding self-disorders, which reflects a key aspect of psychosis. We suggest that the importance of FRS may indeed be

  18. Dual Modulation Faraday Rotation Spectroscopy of HO2

    CERN Document Server

    Brumfield, Brian; Ju, Yiguang; Wysocki, Gerard

    2013-01-01

    The technique of dual modulation Faraday rotation spectroscopy has been applied for near shot-noise limited detection of HO2 at the exit of an atmospheric pressure flow reactor. This was achieved by combining direct current modulation at 51 kHz of an external cavity quantum cascade laser system with 610 Hz modulation of the magnetic field generated by a Helmholtz coil. The DM-FRS measurement had a 1.8 times better signal-to-noise ratio than an AC-FRS measurement acquired under identical flow reactor conditions. Harmonic detection of the FRS signal also eliminated the substantial DC-offset associated with electromagnetic intereference pick-up from the Helmholtz coils that is observed in the AC-FRS spectrum. A noise equivalent angle of 4x10^(-9) rad Hz^(-1/2) was observed for the DM-FRS measurement, and this corresponds to a 3 sigma detection limit of 0.2 ppmv Hz^(-1/2).

  19. Impaired implicit sequence learning in Parkinson's disease patients with freezing of gait.

    Science.gov (United States)

    Vandenbossche, Jochen; Deroost, Natacha; Soetens, Eric; Coomans, Daphné; Spildooren, Joke; Vercruysse, Sarah; Nieuwboer, Alice; Kerckhofs, Eric

    2013-01-01

    Freezing of gait (FOG) in Parkinson's disease (PD) may involve specific impairments in acquiring automaticity under working memory load. This study examined whether implicit sequence learning, with or without a secondary task, is impaired in patients with FOG. Fourteen freezers (FRs), 14 nonfreezers (nFRs), and 14 matched healthy controls (HCs) performed a serial reaction time (SRT) task with a deterministic stimulus sequence under single-task (ST) and dual-task (DT) conditions. The increase in reaction times (RTs) for random compared with sequenced blocks was used as a measure of implicit sequence learning. Neuropsychological tests assessing global cognitive functioning and executive dysfunction were administered in order to investigate their relation to sequence learning. nFRs and HCs showed significant implicit sequence learning effects (p < 0.001). FRs demonstrated a tendency to learn sequence-specific information in the SRT-ST task (p = 0.07) but not in the SRT-DT task (p = 0.69). Severity of FOG, however, correlated positively with SRT-DT task performance (r = -0.56; p < 0.05). The present results suggest that PD patients suffering from FOG pathology exhibit a specific impairment in the acquisition of automaticity. When working memory capacity is supplementarily loaded by adding a DT, sequence learning in FRs becomes increasingly impaired. These findings indicate that therapies should focus on extensive training in acquiring novel motor activities and reducing working memory load to improve learning in FOG.

  20. Flame retardants on the surface of phones and personal computers.

    Science.gov (United States)

    Zheng, Xiaobo; Sun, Runxia; Qiao, Lin; Guo, Huiying; Zheng, Jing; Mai, Bixian

    2017-12-31

    Mobile phones and personal computers (PCs) are essential products that are frequently contacted in daily life. Thus, phones and computers containing flame retardants (FRs) may play vital roles in human exposure to FRs. We measured several FRs, including polybrominated diphenyl ethers (PBDEs), 1,2-bis(2,4,6-tribromophenoxy) ethane (BTBPE), decabromodiphenyl ethane (DBDPE), tetrabromobisphenol (TBBPA), and phosphate flame retardants (PFRs), on the surfaces of phones and PCs (laptop keyboards and mice). Triphenyl phosphate (TPHP, 228pg/cm(2)) and tris(chloroisopropyl) phosphate (TCIPP, 43pg/cm(2)) were the most abundant chemicals on the surfaces of phones, while TPHP (65pg/cm(2)), TCIPP (48pg/cm(2)), and DBDPE (22pg/cm(2)) were dominant on the surfaces of PCs. The usage time and time after the production of the electronics were not significantly correlated with the FR concentrations, except for that of BDE 209. The concentrations of FRs differed on the surfaces of different brands of electronics. Dermal contact with the surface of electronics may contribute to human exposure to FRs, which should be of concern. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. Association between Framingham risk score and subclinical atherosclerosis among elderly with both type 2 diabetes mellitus and healthy subjects

    Science.gov (United States)

    Amer, Moatassem S; Khater, Mohamed S; Omar, Omar H; Mabrouk, Randa A; Mostafa, Shimaa A

    2014-01-01

    Framingham risk score (FRS) is a widely used tool to identify asymptomatic individuals who are at risk to cardiovascular disease. We aimed to investigate the association between subclinical atherosclerosis and FRS among elderly with both type 2 diabetes mellitus and healthy participants. Methods: As case-control study was done on 58 men and women, who had type 2 diabetes mellitus, and in 59 age and gender matched control participants. They were selected from a geriatric outpatient clinic at Ain Shams University Hospital, Cairo, Egypt. The carotid intima-media thickness (cIMT), clinical variables, plasma lipid profile, high-sensitivity C-reactive protein (hs-CRP) were measured for each participants. Results: Diabetic patients had higher FRS, body mass index (BMI), fasting glucose, total cholesterol level, and LDL levels than control subjects. Mean cIMT values were higher in diabetic than healthy subjects. After multivariate regression analysis, FRS was independently associated with carotid IMT in type 2 diabetes patients after adjustment for other risk factors. However triglycerides and BMI were independently associated with cIMT among the control group. Conclusion: FRS is likely to be more informative about the atherosclerotic state in diabetics but not in the healthy elderly. PMID:24551481

  2. Occurrence of emerging flame retardants from e-waste recycling activities in the northern part of Vietnam

    Directory of Open Access Journals (Sweden)

    Masayuki Someya

    2016-06-01

    Full Text Available This study investigated the contamination status of 21 emerging flame retardants (FRs in soils (n = 32 and river sediments (n = 8 from an e-waste recycling (EWR site in the northern part of Vietnam. Among analyzed FRs, higher levels of decabromodiphenyl ethane (DBDPE (ND–4200 ng/g dw, 1,2-bis-(2,4,6-tribromophenoxyethane (BTBPE (ND–350 ng/g dw and Dechlorane Plus isomers (DPs (ND–65 ng/g dw were found in soils near EWR workshops and open burning places. The highest concentrations of DBDPE (20 ng/g dw, BTBPE (5.7 ng/g dw and DPs (6.7 ng/g dw were also detected in sediments collected from the middle of the EWR site. The levels decreased concomitantly with increasing distance from the EWR site. These results indicate that these FRs were released to the surrounding environment from improper recycling activities, such as manual dismantling of devices and open burning of e-wastes. Moreover, the estimated daily intakes of those FRs via soil ingestion were approximately ten times higher for children than adults. To our knowledge, this is a first comprehensive study on characterization of soil and sediment contamination by a series of emerging FRs at an EWR site in Vietnam.

  3. Final Report - Spent Nuclear Fuel Retrieval System Manipulator System Cold Validation Testing

    Energy Technology Data Exchange (ETDEWEB)

    D.R. Jackson; G.R. Kiebel

    1999-08-24

    Manipulator system cold validation testing (CVT) was performed in support of the Fuel Retrieval System (FRS) Sub-Project, a subtask of the Spent Nuclear Fuel Project at the Hanford Site in Richland, Washington. The FRS will be used to retrieve and repackage K-Basin Spent Nuclear Fuel (SNF) currently stored in old K-Plant storage basins. The FRS is required to retrieve full fuel canisters from the basin; clean the fuel elements inside the canister to remove excessive uranium corrosion products (or sludge); remove the contents from the canisters; and sort the resulting debris, scrap, and fuel for repackaging. The fuel elements and scrap will be collected in fuel storage and scrap baskets in preparation for loading into a multi canister overpack (MCO), while the debris is loaded into a debris bin and disposed of as solid waste. The FRS is composed of three major subsystems. The Manipulator Subsystem provides remote handling of fuel, scrap, and debris; the In-Pool Equipment subsystem performs cleaning of fuel and provides a work surface for handling materials; and the Remote Viewing Subsystem provides for remote viewing of the work area by operators. There are two complete and identical FRS systems, one to be installed in the K-West basin and one to be installed in the K-East basin. Another partial system will be installed in a cold test facility to provide for operator training.

  4. Root Structure and Belowground Biomass of Hybrid Poplar in Forestry and Agroforestry Systems in Mediterranean France

    Directory of Open Access Journals (Sweden)

    Kaushalendra Kumar JHA

    2017-09-01

    Full Text Available In poplar, one of the most used species of forestry and agroforestry, below ground biomass allocation plays an important role in providing anchorage as well as efficient nutrient and water distribution channel. Available literature on this aspect is not enough in hybrid Poplar, Populus euramaricana I-214. Therefore, the study was aimed at finding how this species developed its root system and how much belowground biomass was allocated in Forest System (FRS and Agroforest System (AFS. This was done using soil excavation and root coring methods. Coarse roots were distributed in all directions but their number and proximal cross section area (CSA were not uniform. In the case of AFS tree maximum CSA was distributed in the south and south-west direction while in FRS it was in the north-east and south-east direction. Fine roots were observed throughout the rooting zone along with coarse and medium roots up to a maximum depth of 2.4 m in FRS and 2.8 m in AFS. Total belowground biomass was higher in AFS tree (130 kg tree-1 than FRS tree (120 kg tree-1. But on hectare basis FRS accumulated (24.5 Mg ha-1 more biomass than AFS (18.1 Mg ha-1. However, if practiced in surplus agriculture area and considered the system as a whole, AFS allows grain production in lieu of some biomass deficit.

  5. [Study on the classification of dominant pathogens related to febrile respiratory syndrome, based on the method of Bayes discriminant analysis].

    Science.gov (United States)

    Li, X C; Li, J S; Meng, L; Bai, Y N; Yu, D S; Liu, X N; Liu, X F; Jiang, X J; Ren, X W; Yang, X T; Shen, X P; Zhang, J W

    2017-08-10

    Objective: To understand the dominant pathogens of febrile respiratory syndrome (FRS) patients in Gansu province and to establish the Bayes discriminant function in order to identify the patients infected with the dominant pathogens. Methods: FRS patients were collected in various sentinel hospitals of Gansu province from 2009 to 2015 and the dominant pathogens were determined by describing the composition of pathogenic profile. Significant clinical variables were selected by stepwise discriminant analysis to establish the Bayes discriminant function. Results: In the detection of pathogens for FRS, both influenza virus and rhinovirus showed higher positive rates than those caused by other viruses (13.79%, 8.63%), that accounting for 54.38%, 13.73% of total viral positive patients. Most frequently detected bacteria would include Streptococcus pneumoniae , and haemophilus influenza (44.41%, 18.07%) that accounting for 66.21% and 24.55% among the bacterial positive patients. The original-validated rate of discriminant function, established by 11 clinical variables, was 73.1%, with the cross-validated rate as 70.6%. Conclusion: Influenza virus, Rhinovirus, Streptococcus pneumoniae and Haemophilus influenzae were the dominant pathogens of FRS in Gansu province. Results from the Bayes discriminant analysis showed both higher accuracy in the classification of dominant pathogens, and applicative value for FRS.

  6. Commentary on: "Randomized, controlled, double-blind, cross-over trial assessing treatment preference for pazopanib versus sunitinib in patients with metastatic renal cell carcinoma: PISCES study." Escudier B, Porta C, Bono P, Powles T, Eisen T, Sternberg CN, Gschwend JE, De Giorgi U, Parikh O, Hawkins R, Sevin E, Négrier S, Khan S, Diaz J, Redhu S, Mehmud F, Cella D. Bernard Escudier, Institut Gustave Roussy, Villejuif; Emmanuel Sevin, Centre François Baclesse, Caen; Sylvie Négrier, Leon Berard Cancer Center, Lyon, France; Camillo Porta, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico S. Matteo, Pavia; Cora N Sternberg, San Camillo Forlanini Hospital, Rome; Ugo De Giorgi, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy; Petri Bono, Helsinki University Central Hospital, Helsinki, Finland; Thomas Powles, Barts Experimental Cancer Medicine Centre, Barts Cancer Institute, Queen Mary University of London, London; Tim Eisen, Cambridge University Health Partners, Cambridge; Omi Parikh, Royal Preston Hospital, Lancashire; Robert Hawkins, Christie Cancer Research UK, Manchester; Sadya Khan, Jose Diaz, and Faisal Mehmud, GlaxoSmithKline, Uxbridge, United Kingdom; Jürgen E Gschwend, Klinikum Rechts der Isar der Technischen Universität München, Munich, Germany; Suman Redhu, GlaxoSmithKline, Collegeville, PA; David Cella, Northwestern University Feinberg School of Medicine, Chicago, IL.: J Clin Oncol. 2014 May 10;32(14):1412-1418; doi: 10.1200/JCO.2013.50.8267. [Epub 2014 Mar 31].

    Science.gov (United States)

    Trump, Donald

    2016-05-01

    Patient-reported outcomes may help inform treatment choice in advanced/metastatic renal cell carcinoma (RCC), particularly between approved targeted therapies with similar efficacy. This double-blind crossover study evaluated patient preference for pazopanib or sunitinib and the influence of health-related quality of life (HRQoL) and safety factors on their stated preference. Patients with metastatic renal cell carcinoma were randomly assigned to pazopanib 800mg per day for 10 weeks, a 2-week washout, and then sunitinib 50mg per day (4 weeks on, 2 weeks off, 4weeks on) for 10 weeks, or the reverse sequence. The primary end point, patient preference for a specific treatment, was assessed by questionnaire at the end of the two treatment periods. Other end points and analyses included reasons for preference, physician preference, safety, and HRQoL. Of 169 randomly assigned patients, 114 met the following prespecified modified intent-to-treat criteria for the primary analysis: exposure to both treatments, no disease progression before cross over, and completion of the preference questionnaire. Significantly more patients preferred pazopanib (70%) over sunitinib (22%); 8% expressed no preference (P<.001). All preplanned sensitivity analyses, including the intent-to-treat population, statistically favored pazopanib. Less fatigue and better overall quality of life were the main reasons for preferring pazopanib, with less diarrhea being the most cited reason for preferring sunitinib. Physicians also preferred pazopanib (61%) over sunitinib (22%); 17% expressed no preference. Adverse events were consistent with each drug׳s known profile. Pazopanib was superior to sunitinib in HRQoL measures evaluating fatigue, hand/foot soreness, and mouth/throat soreness. This innovative crossover trial demonstrated a significant patient preference for pazopanib over sunitinib, with HRQoL and safety as key influencing factors. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Positive and negative sudden impulses caused by fast forward and reverse interplanetary shocks

    Energy Technology Data Exchange (ETDEWEB)

    Andrioli, Vania Fatima; Savian, Jairo Francisco, E-mail: vaniafatima@gmail.com, E-mail: savian@lacesm.ufsm.br [Space Science Laboratory of Santa Maria - LACESM/CT - UFSM, Universidade Federal de Santa Maria - UFSM, Centro Tecnologico, Santa Maria, RS (Brazil); Echer, Ezequiel, E-mail: eecher@dge.inpe.br [National Institute for Space Research - INPE - MCT, Sao Jose dos Campos, SP (Brazil); Schuch, Nelson Jorge, E-mail: njschuch@lacesm.ufsm.br [Southern Regional Space Research Center - CRSPE/INPE - MCT, Universidade Federal de Santa Maria - UFSM, Santa Maria, RS (Brazil)

    2007-07-01

    Fast forward interplanetary shocks (FFS) are characterized by positive jump in all interplanetary plasma parameters (solar wind speed, temperature and density) and interplanetary magnetic field. However the fast reverse interplanetary shocks (FRS) are characterized by negative jump in all mentioned parameters except solar wind speed. Observations show that FFS cause positive sudden impulses (SI) while FRS cause negative SI in the H-component of the geomagnetic field. In this work we investigate the SI caused by interplanetary shocks. We use the observed plasma parameters, upstream and downstream, to calculate the variation of dynamic pressure. We observe that the SI amplitude is larger for positive SI than for negative ones, as a consequence of the fact that FFS have larger dynamic pressure variations as compared to FRS. (author)

  8. The fibroblast growth factor receptor (FGFR) agonist FGF1 and the neural cell adhesion molecule-derived peptide FGL activate FGFR substrate 2alpha differently

    DEFF Research Database (Denmark)

    Chen, Yongshuo; Li, Shizhong; Berezin, Vladimir

    2010-01-01

    Activation of fibroblast growth factor (FGF) receptors (FGFRs) both by FGFs and by the neural cell adhesion molecule (NCAM) is crucial in the development and function of the nervous system. We found that FGFR substrate 2alpha (FRS2alpha), Src homologous and collagen A (ShcA), and phospholipase......-Cgamma (PLCgamma) were all required for neurite outgrowth from cerebellar granule neurons (CGNs) induced by FGF1 and FGL (an NCAM-derived peptide agonist of FGFR1). Like FGF1, FGL induced tyrosine phosphorylation of FGFR1, FRS2alpha, ShcA, and PLCgamma in a time- and dose-dependent manner. However, the activation...... of FRS2alpha by FGL was significantly lower than the activation by FGF1, indicating a differential signaling profile induced by NCAM compared with the cognate growth factor....

  9. Framingham Risk Score and Estimated 10-Year Cardiovascular Disease Risk Reduction by a Short-Term Yoga-Based LifeStyle Intervention.

    Science.gov (United States)

    Yadav, Rashmi; Yadav, Raj Kumar; Sarvottam, Kumar; Netam, Ritesh

    2017-09-01

    The aim of this study was to evaluate the efficacy of a short-term yoga-based lifestyle intervention program in lowering Framingham Risk Score (FRS) and estimated 10-year cardiovascular risk. This was a single-arm, pre-post interventional study including data from a historical cohort with low to moderate risk for cardiovascular disease (CVD). It was conducted in a tertiary-care hospital. Participants with low (0 or 1 CVD risk factors) to moderately high risk (10-year risk between 10% and 20% and two or more CVD risk factors) were included. Participants with previously diagnosed CVD, defined as a history of myocardial infarction, congestive heart failure, or cerebrovascular accident, were excluded from the analysis. However, those with controlled hypertension were included. Intervention included a pretested short-term yoga-based lifestyle intervention, which included asanas (physical postures), pranayama (breathing exercises), meditation, relaxation techniques, stress management, group support, nutrition awareness program, and individualized advice. The intervention was for 10 days, spread over 2 weeks. However, participants were encouraged to include it in their day-to-day life. Outcomes included changes in FRS, and estimated 10-year CVD risk from baseline to week 2. A gender-based subgroup analysis was also done, and correlation between changes in FRS and cardiovascular risk factors was evaluated. Data for 554 subjects were screened, and 386 subjects (252 females) were included in the analysis. There was a significant reduction in FRS (p yoga-based intervention. There was a strong positive correlation between reduction in FRS and serum total cholesterol (r = 0.60; p yoga-based lifestyle intervention program significantly reduced the CVD risk, as shown by lowered FRS and estimated 10-year CVD risk. Further testing of this promising intervention is warranted in the long term.

  10. Relevance of intermediate-density lipoprotein cholesterol to Framingham risk score of coronary heart disease in middle-aged men with increased non-HDL cholesterol.

    Science.gov (United States)

    Ito, Kumie; Yoshida, Hiroshi; Yanai, Hidekatsu; Kurosawa, Hideo; Sato, Ryo; Manita, Daisuke; Hirowatari, Yuji; Tada, Norio

    2013-10-09

    Cholesterol levels of non-high-density lipoprotein (non-HDL), which contains low-density lipoprotein (LDL), intermediate-density lipoprotein (IDL), very low-density lipoprotein (VLDL) and chylomicron (CM) remnant, have been proven to perform a significant predictor of coronary heart disease (CHD) better than LDL-cholesterol regardless of triglyceride (TG) levels. The present study investigated the relevance of TG-rich lipoproteins (IDL, VLDL, CM) to Framingham risk score (FRS) predictive of 10-year CHD risk. Lipoprotein profiles (cholesterol levels of HDL, LDL, IDL, VLDL, CM) in Japanese men (n = 487) who underwent medical check-up were determined by using our developed anion-exchange high performance liquid chromatography (AEX-HPLC). Total-cholesterol (TC), TG, fasting blood sugar (FBS) and hemoglobin (Hb) A1c were measured by routine methods. The lipoprotein profiles, non-HDL-cholesterol, TC, and TG were examined on these associations with FRS. The lipid levels except for CM-cholesterol were significantly different between two groups (low FRS, cholesterol were significantly and positively correlated with FRS. Among them, the significant association of non-HDL-cholesterol to FRS was noted (r = 0.411, P cholesterol, IDL-cholesterol in TG-rich lipoproteins was significantly correlated with FRS in independently of BMI. These correlation results were similarly found even when the part of the study subjects (n = 348) without the drug therapy for hyperlipidemia, diabetes, and hypertension was investigated. These results suggest that IDL-cholesterol may serve as a useful marker for CHD risk in Japanese men with increased non-HDL-cholesterol. © 2013.

  11. Development of a new risk model for predicting cardiovascular events among hemodialysis patients: Population-based hemodialysis patients from the Japan Dialysis Outcome and Practice Patterns Study (J-DOPPS).

    Science.gov (United States)

    Matsubara, Yukiko; Kimachi, Miho; Fukuma, Shingo; Onishi, Yoshihiro; Fukuhara, Shunichi

    2017-01-01

    Cardiovascular (CV) events are the primary cause of death and becoming bedridden among hemodialysis (HD) patients. The Framingham risk score (FRS) is useful for predicting incidence of CV events in the general population, but is considerd to be unsuitable for the prediction of the incidence of CV events in HD patients, given their characteristics due to atypical relationships between conventional risk factors and outcomes. We therefore aimed to develop a new prognostic prediction model for prevention and early detection of CV events among hemodialysis patients. We enrolled 3,601 maintenance HD patients based on their data from the Japan Dialysis Outcomes and Practice Patterns Study (J-DOPPS), phases 3 and 4. We longitudinaly assessed the association between several potential candidate predictors and composite CV events in the year after study initiation. Potential candidate predictors included the component factors of FRS and other HD-specific risk factors. We used multivariable logistic regression with backward stepwise selection to develop our new prediction model and generated a calibration plot. Additinially, we performed bootstrapping to assess the internal validity. We observed 328 composite CV events during 1-year follow-up. The final prediction model contained six variables: age, diabetes status, history of CV events, dialysis time per session, and serum phosphorus and albumin levels. The new model showed significantly better discrimination than the FRS, in both men (c-statistics: 0.76 for new model, 0.64 for FRS) and women (c-statistics: 0.77 for new model, 0.60 for FRS). Additionally, we confirmed the consistency between the observed results and predicted results using the calibration plot. Further, we found similar discrimination and calibration to the derivation model in the bootstrapping cohort. We developed a new risk model consisting of only six predictors. Our new model predicted CV events more accurately than the FRS.

  12. Relación entre factores de riesgo de salud y costos médicos directos en una población trabajadora peruana durante el año 2003.

    Directory of Open Access Journals (Sweden)

    Juan Carlos PALOMINO BALDEÓN

    2006-04-01

    Full Text Available Objetivo: Hallar la relación entre Factores de Riesgo de Salud (FRS y costos médicos directos en una población trabajadora peruana. Materiales y Métodos: Se realizó un estudio en una población de trabajadores del área de minería; se incluyeron a todos los trabajadores que habían realizado el examen médico anual 2003. Se utilizó la herramienta de valoración de estado de salud (HRA del servicio de Medicina Ocupacional donde se atienden los trabajadores, en el cual se consignan datos generales y además se evalúan 7 FRS: 1. Consumo de tabaco; 2. Consumo de alcohol; 3.Presión arterial >125/90; 4.Glucosa en sangre >110; 5.Colesterol > 240; 6. Indice de masa corporal (IMC>25 y 7. Diagnóstico y prescripción de medicamentos durante el año de estudio para ansiedad o depresión. Se relacionaron los costos médicos directos promedios anuales con el número de FRS, además de comparar los costos y la presencia o no de FRS específico. El análisis estadístico se realizó con un modelo multivariado usando regresión lineal. Resultados: En el análisis se encontró a una asociación positiva con la edad, tiempo de trabajo en la empresa, presencia de FRS y número de FRS con mayores costos médicos directos. Conclusión: En esta población trabajadora peruana el número de factores de riesgo de salud correlaciona directamente con mayores costos directos de salud (Rev Med Hered 2006;17:90-95.

  13. Cardiovascular risk assessment in the treatment of nonalcoholic steatohepatitis: a secondary analysis of the MOZART trial.

    Science.gov (United States)

    Lin, Steven C; Ang, Brandon; Hernandez, Carolyn; Bettencourt, Ricki; Jain, Rashmi; Salotti, Joanie; Richards, Lisa; Kono, Yuko; Bhatt, Archana; Aryafar, Hamed; Lin, Grace Y; Valasek, Mark A; Sirlin, Claude B; Brouha, Sharon; Loomba, Rohit

    2016-03-01

    Nonalcoholic steatohepatitis (NASH) is associated with increased cardiovascular risk and mortality. No US Food and Drug Administration (FDA) approved therapies for NASH are available; clinical trials to date have not yet systematically assessed for changes in cardiovascular risk. This study examines the prospective utility of cardiovascular risk assessments, the Framingham risk score (FRS) and coronary artery calcium (CAC) score, as endpoints in a NASH randomized clinical trial, and assesses whether histologic improvements lead to lower cardiovascular risk. Secondary analysis of a 24-week randomized, double-blind, placebo-controlled trial (MOZART) in which 50 biopsy-proven NASH patients received oral ezetimibe 10 mg daily (n = 25) versus placebo (n = 25). Biochemical profiling, FRS, CAC scores, liver biopsies were obtained at baseline and endpoint. Ezetimibe improved FRS whereas placebo did not (4.4 ± 6.2 to 2.9 ± 4.8, p = 0.038; 3.0 ± 4.4 to 2.9 ± 4.2, p = 0.794). CAC scores did not change with ezetimibe or placebo (180.4 ± 577.2 to 194.1 ± 623.9, p = 0.293; 151.4 ± 448.9 to 183.3 ± 555.7, p = 0.256). Ezetimibe improved FRS and CAC scores in more patients than placebo (48% versus 23%, p = 0.079, and 21% versus 0%, p = 0.090, respectively), though not significantly. No differences were noted in cardiovascular risk scores among histologic responders versus nonresponders. Ezetimibe improved FRS whereas placebo did not. FRS and CAC scores improved in a greater proportion of patients with ezetimibe; this trend did not reach significance. These findings indicate the utility and feasibility of monitoring cardiovascular risk in a NASH trial. The utility of CAC scores may be higher in trials of longer duration (⩾52 weeks) and with older patients (age ⩾45). ClinicalTrials.gov registration: NCT01766713.

  14. A photoelectrochemical immunosensor for detection of α-fetoprotein based on Au-ZnO flower-rod heterostructures

    Energy Technology Data Exchange (ETDEWEB)

    Han, Zhizhong, E-mail: zzhan@fjmu.edu.cn; Luo, Min; Chen, Li; Chen, Jinghua; Li, Chunyan, E-mail: cyli65@126.com

    2017-04-30

    Highlights: • Au NPs were deposited onto ZnO FRs by cyclic voltammetry methods. • Au NPs were used to enhance light absorption and photo-induced charge separation. • The PEC immunosensor based on Au-ZnO FRs presented a higher photocurrent. • The detection limit of this novel PEC immunosensor was 0.56 pg mL{sup −1} for AFP. - Abstract: In this work, a novel label free photoelectrochemical (PEC) immunosensor has been developed for the detection of α-fetoprotein (AFP). The immunosensor was based on Au-ZnO flower-rods (FRs) heterostructure, where Au nanoparticles (NPs) were firstly electrodeposited by cyclic voltammetry methods. Scanning electron microscopy (SEM), X-ray diffraction (XRD), Mott-Schottky plot (MS), UV–vis diffuse reflectance spectrum and fluorescence emission spectrum were used for the characterizations of Au-ZnO FRs. The results demonstrated that Au NPs not only obviously enhanced the visible light absorption of ZnO FRs due to surface plasmon resonance (SPR) but also improved the separation of photo-generated electron-hole pairs. Therefore, the photocurrent of Au-ZnO FRs was increased under simulated sunlight. The photocurrent was reduced after the specific antibody-antigen immune reaction. And the photocurrent decrement was linear with the logarithm of AFP antigen concentration in the range from 0.005 ng mL{sup −1} to 50 ng mL{sup −1} with a low detection limit of 0.56 pg mL{sup −1} (S/N = 3). The PEC immunosensor also exhibited high anti-interference property and acceptable stability. This work would provide a promising photoelectrochemical strategy for the detection of other proteins in clinical diagnosis.

  15. First-rank symptoms and premorbid adjustment in young individuals at increased risk of developing psychosis.

    Science.gov (United States)

    Morcillo, C; Stochl, J; Russo, D A; Zambrana, A; Ratnayake, N; Jones, P B; Perez, J

    2015-01-01

    Individuals at clinical high risk (CHR) for psychosis represent a heterogeneous group with a high rate of comorbid psychiatric disorders. There is little information on whether certain qualitative aspects of psychotic symptoms among CHR individuals may be predictive of future psychosis. This study focused on describing the prevalence of first-rank symptoms (FRS) among a sample of CHR individuals and its association with future transition to psychosis and, from a neurodevelopmental perspective, the level of adjustment of individuals at CHR during their childhood was also analysed. Participants comprised 60 individuals at CHR (according to the Comprehensive Assessment of At-Risk Mental States, CAARMS) at the time of their referral to an early intervention service and 60 healthy volunteers (HVs). All subjects were assessed by senior research clinicians using the Mini International Neuropsychiatric Interview (MINI), and the Positive and Negative Syndrome Scale (PANSS). FRS were defined according to Kurt Schneider's original classification, and information was collected from PANSS, CAARMS and clinical reports. Early premorbid functioning was measured using the Premorbid Adjustment Scale (PAS). We grouped individuals by number and type of FRS and analysed transitions to full-blown psychosis over a 2-year follow-up period. We also correlated the general social and functional adjustment of these individuals during their childhood (6-11 years of age) with the future development of mental states at CHR and FRS. Over 69% of CHR individuals had more than one DSM-IV psychiatric diagnosis, mainly within the affective and anxiety diagnostic spectra. At least one FRS was present in 43.3% of CHR individuals, and 21.6% of these had more than one. Auditory hallucinations and passivity experiences were the most commonly reported. Only 10% of individuals at CHR made a transition to first-episode psychosis (FEP) over 2 years and, except for passivity experiences, the presence of one or

  16. Performance profiles of major energy producers, 1991. [Contains glossary

    Energy Technology Data Exchange (ETDEWEB)

    1992-12-31

    Performance Profiles of Major Energy Producers 1991 is the fifteenth annual report of the Energy Information Administration's (EIA) Financial Reporting System (FRS). The report examines financial and operating developments, with particular reference to the 23 major energy companies (the FRS companies) required to report annually on Form EIA-28. It also traces key developments affecting the financial performance of major energy companies in 1991, as well as reviews important trends. Financial information is reported by major lines of business including oil and gas production, petroleum refining and marketing, and other energy operations. Domestic and international operations are examined separately in this report.

  17. Performance profiles of major energy producers, 1991

    Energy Technology Data Exchange (ETDEWEB)

    1992-12-31

    Performance Profiles of Major Energy Producers 1991 is the fifteenth annual report of the Energy Information Administration`s (EIA) Financial Reporting System (FRS). The report examines financial and operating developments, with particular reference to the 23 major energy companies (the FRS companies) required to report annually on Form EIA-28. It also traces key developments affecting the financial performance of major energy companies in 1991, as well as reviews important trends. Financial information is reported by major lines of business including oil and gas production, petroleum refining and marketing, and other energy operations. Domestic and international operations are examined separately in this report.

  18. Rate-dependent performance of ion chambers for particle-ID at the GSI fragment separator

    Energy Technology Data Exchange (ETDEWEB)

    Hucka, Jan-Paul; Allred, Timothy; Enders, Joachim [Institut fuer Kernphysik, TU Darmstadt (Germany); Gernhaeuser, Roman; Maurus, Steffen [Physik Department, TU Muenchen (Germany); Nociforo, Chiara; Pietri, Stephane; Prochazka, Andrej [GSI Helmholtzzentrum fuer Schwerionenforschung (Germany)

    2015-07-01

    At the GSI Fragment Separator (FRS), multi-sampling ion chambers (MUSIC) employing a Frisch grid are used for charge identification of secondary ion beams. At the FAIR Super-FRS, higher rates are expected, and an event-by-event determination of the charge of secondary ions will be needed at rates of several 100000 events per second. The comparison of results from test measurements for the MUSIC performance with that of a recently constructed tilted-electrode gas ion chamber (TEGIC), which was designed similar to the one discussed, is presented.

  19. Fluctuation relations with intermittent non-Gaussian variables.

    Science.gov (United States)

    Budini, Adrián A

    2011-12-01

    Nonequilibrium stationary fluctuations may exhibit a special symmetry called fluctuation relations (FRs). Here, we show that this property is always satisfied by the subtraction of two random and independent variables related by a thermodynamiclike change of measure. Taking one of them as a modulated Poisson process, it is demonstrated that intermittence and FRs are compatible properties that may coexist naturally. Strong non-Gaussian features characterize the probability distribution and its generating function. Their associated large deviation functions develop a "kink" at the origin and a plateau regime respectively. Application of this model in different stationary nonequilibrium situations is discussed.

  20. Development of Novel Mid-Infrared Spectrometers Based on Quantum Cascade Lasers

    Science.gov (United States)

    Wang, Yin

    Sensitive detection of trace gas molecules has various important applications in environmental science, medical diagnostics and homeland security. The invention of quantum cascade lasers (QCLs) has triggered development of compact, efficient and highly sensitive mid-infrared (mid-IR) spectroscopic techniques. This dissertation is primarily focused on Faraday rotation spectroscopy (FRS) for detection of gas-phase radicals, and new methods to perform broadband, high-resolution mid-IR spectroscopy. The developed techniques allow the sensor to reach quantum limit in the real-world settings. The noise in traditional FRS systems is typically far above the quantum shot-noise due to the strong laser noise at its spectral base-band. Here, a method employing heterodyne-enhanced FRS (H-FRS) is developed. Through optical heterodyning, the signal is shifted from the low frequency to radio frequencies (RF), where the noise is strongly suppressed, allowing significant improvement of the signal-to-noise ratio. An experimental demonstration of H-FRS was performed using a distributed feedback QCL and a mercury-cadmium-telluride photodetector. The cryogen-free system exhibited the total noise of 3.7 times higher than the quantum shot-noise. The complex optical design of H-FRS limits its application only to laboratory conditions. To overcome this issue a dual modulation FRS method that requires much simpler set-up and is capable of even higher performance than H-FRS is proposed. A prototype was built as a robust transportable system and was delivered to Cleveland Clinic for the first, proof-of-principle isotopic studies of nitric oxide metabolism in human body. The total noise observed in this system is only two times higher than the quantum shot-noise. A laser testing system for optimizing QCL chips is developed. The system allows for automatic optical alignment and characterization of the QCL chips in an external cavity QCL configuration. Thus it significantly improves the data

  1. Differential incremental value of ultrasound carotid intima-media thickness, carotid plaque, and cardiac calcium to predict angiographic coronary artery disease across Framingham risk score strata in the APRES multicentre study.

    Science.gov (United States)

    Gaibazzi, Nicola; Rigo, Fausto; Facchetti, Rita; Carerj, Scipione; Giannattasio, Cristina; Moreo, Antonella; Mureddu, Gian Francesco; Salvetti, Massimo; Grolla, Elisabetta; Faden, Giacomo; Cesana, Francesca; Faggiano, Pompilio

    2016-09-01

    According to recent data, more accurate selection of patients undergoing coronary angiography for suspected coronary artery disease (CAD) is needed. From the Active PREvention Study multicentre prospective study, we further analyse whether carotid intima-media thickness (cIMT), carotid plaques (cPL), and echocardiographic cardiac calcium score (eCS) have incremental discriminatory and reclassification predictive value for CAD over clinical risk score in subjects undergoing coronary angiography, specifically depending on their low, intermediate, or high class of clinical risk. In eight centres, 445 subjects without history of prior CAD but with chest pain of recent onset and/or a positive/inconclusive stress test for ischaemia prospectively underwent clinically indicated elective coronary angiography after cardiac and carotid ultrasound assessments with measurements of cIMT, cPL, and eCS. The study population was divided into subjects at low (10%), intermediate (10-20%), and high (>20%) Framingham risk score (FRS). Ultrasound parameters were tested for their incremental value to predict CAD over FRS, in each pre-test risk category. No significant difference could be appreciated between the discrimination value of FRS and Diagnostic Imaging for Coronary Artery Disease score for the presence of CAD. eCS or cPL demonstrated significant incremental prediction over FRS, consistently in the three FRS categories (P risk subjects, in whom cPL was apparently not incremental over FRS, and eCS was only of borderline significance for better discrimination. Ultrasound eCS and cPL assessments were significant predictors of angiographic CAD in patients without prior CAD but with signs or symptoms suspect for CAD, independently and incrementally to FRS, across all pre-test risk probability strata, although in high-risk subjects, only eCS maintained an incremental value. The use of cIMT was not significantly incrementally useful in any FRS risk category. Published on behalf of the

  2. Time of flight with a segmented plastic finger detector at high particle rate

    Energy Technology Data Exchange (ETDEWEB)

    Ameil, Frederic; Kurcewicz, Jan; Pietri, Stephane; Ralet, Damian; Gerl, Juergen [GSI, Darmstadt (Germany); Danchev, Miroslav [University Sofia (Bulgaria); Boutachkov, Plamen; Pietralla, Norbert [TU, Darmstadt (Germany)

    2012-07-01

    Improved primary beam intensities and implementation of fast ramping time converts directly into higher yields of exotic nuclei. Improvements to tracking detectors are necessary to allow for higher rates. The segmented plastic finger detector was refurbished, tested and used in several beam times at the FRS and a better resolution was obtained compared to conventional scintillator detectors especially at high particle rate (> 10{sup 6} Hz). A new finger detector with higher segmentation is under development, it can allow for still higher rate and can be also used as tracking detector for the SuperFRS.

  3. Performance profiles of major energy producers 1989

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-23

    Performance Profiles of Major Energy Producers 1989 is the thirteenth annual report of the Energy Information Administration's (EIA) Financial Reporting System (FRS). The report examines financial and operating developments, with particular reference to the 23 major energy companies (the FRS companies'') required to report annually on Form EIA-28. Financial information is reported by major lines of business including oil and gas production, petroleum refining and marketing, and other energy operations. Domestic and international operations are examined separately in this report. It also traces key developments affecting the financial performance of major energy companies in 1989, as well as review of important trends.

  4. Identity Conflicts: A Doctrinal Change Needed?

    Science.gov (United States)

    2014-12-12

    differ from yesterday. ― Marc Bloch, Strange Defeat Introduction The purpose of this thesis is to examine whether the U.S. Army has accepted...Bloch, Marc. 1946. Strange Defeat: A Statement of Evidence Written in 1940. London: W. W. Norton. British Broadcasting Company (BBC). 2006. Iraqi...Raphael. 2010. “A Tale of Two Manuals.” Prism 2, no. 1: 87-100. Collier, Paul, and Anke Hoeffler. 1998. “On Economic Causes of Civil War.” Oxford

  5. Uued näitused Tartus / Mariann Raisma

    Index Scriptorium Estoniae

    Raisma, Mariann, 1974-

    1999-01-01

    27. ja 28. mail Tartus festivali "Dionysia" raames avatud näitused. "Tehis-id" 27. V-13. VI Tartu Kunstimajas. Kuraator Andres Härm. Tartu noorte kunstnike looming Illegaardis ja Obu galeriis. Raphael C. Samueli näitus "Vanemuise" väikeses majas. Resa Tiitsma näitus Mikkeli galeriis. Toomas Miku "Pesa", Kaarel Vulla "Kapitulatsioon" Raekoja platsil. M. M. Kuninga ja Toomas Mürgi projekt kaubamajades. Performance'id Academia Non Gratalt, Tartu kunstikoolilt, Erki Kasemetsalt.

  6. The social determinants of health and the patient safety paradigm.

    Science.gov (United States)

    Gibson, Linda; Odeyemi, Pauline

    This article extends the thesis presented in the paper by Tingle, Gibson and Ferrante (2011) that the patient safety agenda needs to operate within a new paradigm. We will introduce the social determinants of health (SDH) as an emerging discourse in global public health. The SDH advocate social and health equity among nations and individuals, and within countries and communities. It has become a key driver for policy makers, health researchers and public health professionals (Raphael, 2011). This article will demonstrate that the paradigmatic lens of SDH offers the opportunity to develop a more upstream analysis of the patient safety agenda based on health systems.

  7. Comments on responsibility of and trust in ISPs

    OpenAIRE

    Denning, Dorothy E.

    2010-01-01

    The article of record as published may be found at http://dx.doi.org/10.1007/s12130-010-9122-8 Picking up on the themes of ISP responsibility and trust raised by Raphael Cohen-Almagor, this paper discusses the problem of removing inappropriate content from the Internet. It suggests that an approach based on community involvement such as used by YouTube may be preferable to one that relies on artificial intelligence to detect inappropriate content. The paper also suggests ways in which I...

  8. Modelos microscópicos de herança no século XIX: a teoria das estirpes de Francis Galton

    OpenAIRE

    Polizello, Andreza

    2009-01-01

    Francis Galton (1822-1911) trouxe importantes contribuições para diversos campos da ciência. Entre outras coisas, ele foi o fundador da Escola biometricista desenvolvida por Karl Pearson e Walter Frank Raphael Weldon. O objetivo desta dissertação é discutir as idéias de Galton acerca da herança desenvolvidas durante o período compreendido entre 1855 (quando ele publicou seus primeiros trabalhos sobre o assunto) e 1889 (quando ele publicou seu livro Natural inheritance), focalizando especialme...

  9. Start of interconnection on the last sector on 4 April 2007

    CERN Multimedia

    2007-01-01

    Team in charge of interconnexion in front of the first interconnection made in sector 1-2- From left to right : Andrea Musso (CERN-AT-MCS-IC) , Jean-Marc Duse (IEG), André Jacquemod (CERN-AT-MCS-IC), Zenon Sulek (HNINP Krakow),  Mohssen Souayah (IEG), Frédéric Savary (CERN-AT-MCS-IC), Laurent Vaudaux (IEG), Caroline Hopp (IEG), Raphael Menolascina (IEG), Ludovic Savier (IEG) 

  10. Global analysis of VHHs framework regions with a structural alphabet.

    Science.gov (United States)

    Noël, Floriane; Malpertuy, Alain; de Brevern, Alexandre G

    2016-12-01

    The VHHs are antigen-binding region/domain of camelid heavy chain antibodies (HCAb). They have many interesting biotechnological and biomedical properties due to their small size, high solubility and stability, and high affinity and specificity for their antigens. HCAb and classical IgGs are evolutionary related and share a common fold. VHHs are composed of regions considered as constant, called the frameworks (FRs) connected by Complementarity Determining Regions (CDRs), a highly variable region that provide interaction with the epitope. Actually, no systematic structural analyses had been performed on VHH structures despite a significant number of structures. This work is the first study to analyse the structural diversity of FRs of VHHs. Using a structural alphabet that allows approximating the local conformation, we show that each of the four FRs do not have a unique structure but exhibit many structural variant patterns. Moreover, no direct simple link between the local conformational change and amino acid composition can be detected. These results indicate that long-range interactions affect the local conformation of FRs and impact the building of structural models. Copyright © 2016 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.

  11. Blood clinical-chemical parameters and feeding history in growing Japanese quail (Coturnix japonica) chicks exposed to Tris(1,3-dichloro-2-propyl) phosphate and Dechlorane Plus in ovo

    DEFF Research Database (Denmark)

    Jacobsen, Mona Lykke; Jaspers, Veerle L B; Ciesielski, Tomasz M.

    2017-01-01

    Blood clinical-chemical parameters (BCCPs) are used to investigate physiological consequences attributed to exposure to anthropogenic stressors, such as exposure to Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) and Dechlorane Plus (DP), which are flame retardants (FRs), on avian health. Japanese...

  12. Evaluation of Newer Risk Markers for Coronary Heart Disease Risk Classification A Cohort Study

    NARCIS (Netherlands)

    Kavousi, Maryam; Elias-Smale, Suzette; Rutten, Joost H. W.; Leening, Maarten J. G.; Vliegenthart, Rozemarijn; Verwoert, Germaine C.; Krestin, Gabriel P.; Oudkerk, Matthijs; de Maat, Moniek P. M.; Leebeek, Frank W. G.; Mattace-Raso, Francesco U. S.; Lindemans, Jan; Hofman, Albert; Steyerberg, Ewout W.; van der Lugt, Aad; van den Meiracker, Anton H.; Witteman, Jacqueline C. M.

    2012-01-01

    Background: Whether newer risk markers for coronary heart disease (CHD) improve CHD risk prediction remains unclear. Objective: To assess whether newer risk markers for CHD risk prediction and stratification improve Framingham risk score (FRS) predictions. Design: Prospective population-based study.

  13. Home | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2017-07-02

    Jul 2, 2017 ... This month's issue of the Journal of Chemical Sciences honours Professor Charusita Chakravarty, who has made immeasurable contributions to theoretical chemistry and chemical dynamics. The editors Biman Bagchi (FASc, FNA, FTWAS; Indian Institute of Science, Bangalore, India), David Clary (FRS; ...

  14. Predicción del riesgo cardiovascular en pacientes con enfermedad renal crónica

    Directory of Open Access Journals (Sweden)

    Santiago Cedeño Mora

    2017-05-01

    Conclusiones: Las escalas de predicción de RCV (FRS-CVD y ASCVD [AHA/ACC 2013] pueden estimar la probabilidad de sufrir ECV ateroscleróticos en pacientes con ERC independientemente de la función renal, albuminuria y antecedente de ECV.

  15. The negative health consequences of unemployment: the case of Poland.

    Science.gov (United States)

    Kozieł, Sławomir; Lopuszańska, Monika; Szklarska, Alicja; Lipowicz, Anna

    2010-07-01

    In the 1990s Poland began to make a transition to a free-market economy: a transition accompanied by a variety of negative socio-economic developments, most notably a rise in unemployment. The aim of this study is to shed light on the relationship between occupational status (including unemployment) and the risk of cardiovascular disease (CVD), by examining the experience of 542 men and 572 women between the ages of 40 and 50 of the town of Wroclaw in 2006. The Framingham Risk Score (FRS), which uses certain health and life-style parameters to predict the risk of major coronary problems over a 10-year period, was calculated, and the effect of occupational status on the FRS was assessed. The results showed that the FRS varied according to sex and to occupational status, with the highest FRS rating among unemployed men. Thus governmental policies to counter the adverse effects of unemployment should be developed to remedy the problem. 2010 Elsevier B.V. All rights reserved.

  16. New Fellows and Honorary Fellow

    Indian Academy of Sciences (India)

    Mambillikalathil Govind Kumar Ph.D. (Bristol), D.Sc. (h.c.), FRS, FNA, FTWAS Council Service: 1968-85; Vice-President: 1971-73; President: 1974-76. Date of birth: 28 August 1928. Date of death: 22 November 2016. Specialization: Cosmic Rays, Particle Physics Last known address: C-178, First Floor, Sarvodaya Enclave, ...

  17. Weight gain, body image and sexual function in young patients treated with contraceptive vaginal ring. A prospective pilot study.

    Science.gov (United States)

    Morotti, Elena; Casadio, Paolo; Guasina, Francesca; Battaglia, Bruno; Mattioli, Mara; Battaglia, Cesare

    2017-08-01

    Oral contraceptives could induce mood changes. As far as our knowledge, there are no studies in literature that have examined the role of vaginal contraception in self-perceived body image. To evaluate the effects of intravaginal contraception on weight gain and perceived body image in relation with the Beck's Depression Inventory questionnaire (BDI) and the McCoy Female Sexuality Questionnaire (MFSQ). Twenty-one adult (18-35 years old) eumenorrheic (menstrual cycle of 25-35 days), lean (body mass index - BMI - of 19-25 kg/m2) women who were referred for hormonal contraception were administered the Stunkard Figure Rating Scale (FRS), BDI and MFSQ. Subjects were studied in basal condition and after 6 months of therapy with vaginal contraception (NuvaRing®; Organon-Schering-Plough Italia, Milan, Italy). BMI, FRS, MFSQ and BDI. After 6 months of therapy with NuvaRing®, both body weight (60.0 ± 8.3; p = 0.050) and BMI (22.1 ± 3.1; p = 0.028) slightly, but statistically, increased. FRS and BDI showed no differences after the vaginal contraception. Hormonal contraception was associated with a significant decrease in the two-factor Italian MFSQ score. Vaginal ring seems a good alternative to other hormonal contraceptive not significantly altering the female sexuality and not influencing the FRS and BDI.

  18. Reference: 145 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available mediating seedling deetiolation. In summary, our results support the notion that FRS family members play distinct roles...g nuclear gene expression. Arabidopsis FHY3/FAR1 gene family and distinct roles of its members in light cont

  19. Information and Announcements

    Indian Academy of Sciences (India)

    Indian Space Research Organization (ISRO). The aim is to train, in the corning years, select groups of talented students for academic and ... to SPIC Mathematical Institute. C S Seshadri, FRS, a mathematician of international repute, has been heading the institute since its inception and he leads the mathematics group.

  20. Narayan, Prof. Ramesh

    Indian Academy of Sciences (India)

    Narayan, Prof. Ramesh FRS. Date of birth: 25 September 1950. Address: Harvard Smithsonian Centre for, Astrophysics, Harvard University, 60, Garden Street, MS-51, Cambridge, MA 02138, USA Contact: Office: (+1-617) 496 9393. Fax: (+1-617) 495 7053. Email: rnarayan@cfa.harvard.edu. YouTube; Twitter; Facebook ...

  1. Thomas, Prof. Sir John Meurig

    Indian Academy of Sciences (India)

    Thomas, Prof. Sir John Meurig FRS. Date of birth: 15 December 1932. Address: Department of Materials Science and, Metallurgy, New Museums Site, 27, Babbage Road, Cambridge CB3 0FS, U.K.. Contact: Office: (+44-1223) 33 4300. Fax: (+44-1223) 33 4567. Email: jmt2@cam.ac.uk. YouTube; Twitter; Facebook; Blog ...

  2. Lovastatin-Enriched Rice Straw Enhances Biomass Quality and Suppresses Ruminal Methanogenesis

    Directory of Open Access Journals (Sweden)

    Mohammad Faseleh Jahromi

    2013-01-01

    Full Text Available The primary objective of this study was to test the hypothesis that solid state fermentation (SSF of agro-biomass (using rice straw as model; besides, breaking down its lignocellulose content to improve its nutritive values also produces lovastatin which could be used to suppress methanogenesis in the rumen ecosystem. Fermented rice straw (FRS containing lovastatin after fermentation with Aspergillus terreus was used as substrate for growth study of rumen microorganisms using in vitro gas production method. In the first experiment, the extract from the FRS (FRSE which contained lovastatin was evaluated for its efficacy for reduction in methane (CH4 production, microbial population, and activity in the rumen fluid. FRSE reduced total gas and CH4 productions (P<0.01. It also reduced (P<0.01 total methanogens population and increased the cellulolytic bacteria including Ruminococcus albus, Fibrobacter succinogenes (P<0.01, and Ruminococcus flavefaciens (P<0.05. Similarly, FRS reduced total gas and CH4 productions, methanogens population, but increased in vitro dry mater digestibility compared to the non-fermented rice straw. Lovastatin in the FRSE and the FRS significantly increased the expression of HMG-CoA reductase gene that produces HMG-CoA reductase, a key enzyme for cell membrane production in methanogenic Archaea.

  3. Designing a Better Navy Aviation Retention Bonus

    Science.gov (United States)

    2017-03-01

    human worth, community.  Military bearing/character—Appearance, conduct, physical fitness , adherence to Navy Core Values.  Teamwork—Contributions...Federal Aviation Administration FITREP fitness report FOS failure of selection FRG Fleet Replenishment Group FRS Fleet Replenishment Squadron IFS...retention bonus while fitting within the current promotion and advancement system. C. STUDY ORGANIZATION The study is separated into six chapters that

  4. Properties of flat-pressed wood plastic composites containing fire retardants

    Science.gov (United States)

    Nadir Ayrilmis; Jan. T. Benthien; Heiko Thoemen; Robert H. White

    2011-01-01

    This study investigated physical, mechanical, and fire properties of the flat-pressed wood plastic composites (WPCs) incorporated with various fire retardants (FRs) [5 or 15% by weight (wt)] at 50 wt % of the wood flour (WF). The WPC panels were made from dry-blended WF, polypropylene (PP) with maleic anhydride grafted PP (2 wt %), and FR powder formulations using a...

  5. Prevalence of overweight and obesity and perception of healthy and ...

    African Journals Online (AJOL)

    In addition to reported socio-demographic characteristics, medical history, and exercise and diet history, the standardized Stunkard Figure Rating Scale (FRS) was used to identify silhouettes of varying body sizes that most closely resemble a woman's current body image (CBI), the body image she sees as the ideal for ...

  6. Cardiovascular risk prediction in the general population with use of suPAR, CRP, and Framingham Risk Score

    DEFF Research Database (Denmark)

    Lyngbæk, Stig; Marott, Jacob L; Sehestedt, Thomas

    2013-01-01

    for men (p=0.034) and borderline significant for women (p=0.054), while the integrated discrimination improvement was highly significant (P≤0.001) for both genders. CONCLUSIONS: suPAR provides prognostic information of CVD risk beyond FRS and improves risk prediction substantially when combined with CRP...

  7. 2007-2008 Weapon Systems

    Science.gov (United States)

    2007-01-01

    an operation in Ayn Mana, Iraq, June 26, 2006. WEAPON SYSTEMS 2007–2008 Dear Reader: The weapon systems and equipment described in this reference...Ingersoll- Rand (Campbellsville, KY) Forward Repair System (FRS) 103 UNITED STATES ARMY ACQUISITION PHASE INVESTMENT COMPONENT Global Combat...Lightweight Laser Designator Rangefinder (LLDR) Information Systems Support, Inc. Army Key Management System (AKMS) Ingersoll- Rand Forward Repair

  8. 76 FR 28031 - Clarification of Statement of Policy

    Science.gov (United States)

    2011-05-13

    ... into the banking system at some point. However, the FDIC has determined that a conviction for issuing a... of the Federal Reserve System (FRS) and the Office of Thrift Supervision (OTS) in regard to bank and... System. In addition, the FDIC is making certain clarifying changes regarding when an application for the...

  9. Sharma, Prof. Man Mohan

    Indian Academy of Sciences (India)

    Sharma, Prof. Man Mohan Ph.D. (Cantab), D.Sc. (h.c.), D.Engg. (h.c.), LL.D. (h.c.), FNA, FRS Council Service: 1986-88. Date of birth: 1 May 1937. Specialization: Multiphase Reactions/Reactors, Separations Address: 2/3, Jaswant Baug, Behind Akbarallys, V.N. Purav Marg, Chembur, Mumbai 400 071, Maharashtra Contact:

  10. Investigation of lithium ion battery electrolytes containing flame retardants in combination with the film forming electrolyte additives vinylene carbonate, vinyl ethylene carbonate and fluoroethylene carbonate

    Science.gov (United States)

    Dagger, Tim; Grützke, Martin; Reichert, Matthias; Haetge, Jan; Nowak, Sascha; Winter, Martin; Schappacher, Falko M.

    2017-12-01

    In order to address the trade-off between the safety lithium ion battery (LIB) electrolytes and their electrochemical performance, synergetic effects of flame retardant additives (FRs) in combination with film forming additives (FFAs) are investigated. Triphenyl phosphate (TPP) and a silicon-containing additive (WA) are applied as FRs to improve the onset temperature of the thermal runaway of a LIB standard electrolyte (LP57: 1 M LiPF6 in EC:EMC 3:7) about 15 K and 28 K, respectively. The application of the FRs in MCMB graphite/lithium metal and NMC111/lithium metal three-electrode cells induces insufficiencies in terms of charge/discharge cycling stability and rate capability. It is investigated if the addition of FFAs can degrade the insufficiencies that are induced by the FRs. Vinylene carbonate, vinyl ethylene carbonate and fluoroethylene carbonate are added to a mixture of LP57 with 10% FR to enhance the cycling performance via improved interphase formation. Results reveal, that the rate capability of cells containing TPP or WA is especially improved by addition of 2% or 5% FEC, respectively. Postmortem analyses of the electrodes by SEM and of the electrolyte by GC-MS are performed. Direct correlations between the cycling behavior during the C-rate study and the electrolyte decomposition products are drawn.

  11. 77 FR 56194 - Promising and Practical Strategies to Increase Postsecondary Success; Request for Information

    Science.gov (United States)

    2012-09-12

    ... Service (FRS), toll free, at 1- 800-877-8339. Individuals with disabilities can obtain this document in an... obstacles targeted by the intervention. The theory of action that provides the basis for the promising and... through this RFI. Accessible Format: Individuals with disabilities can obtain this document in an...

  12. 77 FR 4550 - Promising and Practical Strategies to Increase Postsecondary Success

    Science.gov (United States)

    2012-01-30

    ... Service (FRS), toll free, at 1-(800) 877-8339. Individuals with disabilities can obtain this document in... addressed, including the dimensions of the problems or obstacles targeted by the intervention. The theory of... information obtained through this RFI. Accessible Format: Individuals with disabilities can obtain this...

  13. Face Recognition using Artificial Neural Network | Endeshaw | Zede ...

    African Journals Online (AJOL)

    Face recognition (FR) is one of the biometric methods to identify the individuals by the features of face. Two Face Recognition Systems (FRS) based on Artificial Neural Network (ANN) have been proposed in this paper based on feature extraction techniques. In the first system, Principal Component Analysis (PCA) has been ...

  14. Correlation study of Framingham risk score and vascular dementia: An observational study.

    Science.gov (United States)

    Li, Shan-Shan; Zheng, Jie; Mei, Bin; Wang, Han-Yao; Zheng, Miao; Zheng, Kai

    2017-12-01

    Vascular dementia (VaD) is one of the most common forms of dementia, and second only to Alzheimer's disease. The purpose of this study was to evaluate the potential diagnostic value of Framingham risk score (FRS) in VaD by investigating the relationship among cardiovascular risks, FRS, and VaD.Data were collected from patients (n = 130) at Tongji Hospital in Wuhan, China. They were divided into 2 groups, including the control group (n = 70) and the VaD group (n = 60). Statistical methods including t-test, logistic regression model, multiple linear regression model, and receiver-operating characteristic (ROC) curve were adopted for the assessment.A significant difference (all P multiple stepwise linear regression analysis showed that the age and FRS were independent predictors of MMSE scores.FRS has a moderate predictive value for the VaD diagnosis, and also increases the risk of cognitive decline. Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.

  15. Dynamic soil properties of some deep trenches in Mashhad city, NE ...

    Indian Academy of Sciences (India)

    Microtremor survey is achieved in order to evaluate the dynamical characteristics of surface layers. For this purpose, 13 trenches were selected and microtremor measurements were performed at the top and bottom of each trench. Floor spectral ratio (FRS) analysis was accomplished to obtain frequency and amplification of ...

  16. Home | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2016-12-26

    Dec 26, 2016 ... This month's issue of the Journal of Chemical Sciences honours Professor Charusita Chakravarty, who has made immeasurable contributions to theoretical chemistry and chemical dynamics. The editors Biman Bagchi (FASc, FNA, FTWAS; Indian Institute of Science, Bangalore, India), David Clary (FRS; ...

  17. Rheology and Segregation of Granular Mixtures in Dense Flows

    Indian Academy of Sciences (India)

    Devang Khakhar

    IIT Bombay. Bagnold Theory. Change in momentum per collision. Bagnold collisional shear stress. R. A. Bagnold, FRS. Brigadier General. Collision rate: Area: .... IIT Bombay. Single Particle Motion. Lower density tracer particles in sheared annulus. Vg. F pt p. ) (ρρ. −. = Force. Song et al., PNAS, 102, 2299-2304 (2005) ...

  18. an assessment of household energy types, sources, uses and its ...

    African Journals Online (AJOL)

    xtz

    household expenditure on the various energy types/sources for the study area was evaluated at about. 10496640 FRS ... steady rise in pressure on them from the .... Fossil fuel. Saw Dust. SD. Cooking. Heating. Saw Mills (forest trees). Cooking Gas (Liquefied. Natural Gas). CG. Cooking. Fossil fuel. Charcoal. CH. Cooking.

  19. Narasimhan, Prof. Mudumbai Seshachalu

    Indian Academy of Sciences (India)

    Narasimhan, Prof. Mudumbai Seshachalu Ph.D. (Mumbai), FNA, FNASc, FRS Council Service: 1977-82; Vice-President: 1980-82. Date of birth: 7 June 1932. Specialization: Algebraic & Differential Geometry and Analysis Address: 9, Guruparadise Apartments, 24, 4th Main Road, Amarjyoti Layout, Sanjay Nagar, Bengaluru ...

  20. Culham names new director

    CERN Multimedia

    2003-01-01

    "The United Kingdom Atomic Energy Authority (UKAEA) announced the appointment of Professor Sir Chris Llewellyn Smith FRS (Fellow of the Royal Society) as Director of Culham, responsible for developing and implementing the strategy for the UK's fusion research programme" (1 page).

  1. NUSTAR and the status of the R3B project at FAIR

    Indian Academy of Sciences (India)

    NUSTAR (nuclear structure, astrophysics and reactions) is a collaboration of the international nuclear structure and astrophysics community with the aim to further explore this method at the FAIR Facility. Within the FAIR complex, NUSTAR defines a facility where the heart is the super-fragment separator (Super-FRS), which ...

  2. 16 May 2012 - SESAME Event at CERN “Collaborative science for peace in the Middle East”

    CERN Multimedia

    Jean-Claude Gadmer

    2012-01-01

    CERN-HI-1205100 07:from left to right: front row: Signature with SESAME Director K.Toukan and CERN Director-General R. Heuer. back row: SESAME co-Vice President S. Aghamiri, SESAME Council President C. Llewellyn Smith FRS and SESAME co-Vice President M. T. Hussein.

  3. Ground-state configuration of neutron-rich Aluminum isotopes through Coulomb Breakup

    NARCIS (Netherlands)

    Chakraborty, S.; Pramanik, U. Datta; Aumann, T.; Beceiro, S.; Boretzky, K.; Caesar, C.; Carlson, B.V.; Catford, W.N.; Chatterjee, S.; Chartier, M.; Cortina-Gil, D.; Angelis, G.De; Gonzalez - Dias, D.; Emling, H.; Diaz Fernandes, P.; Fraile, L.M.; Ershova, O.; Geissel, H.; Heil, M.; Jonson, B.; Kelic, A.; Johansson, H.; Kruecken, R.; Kroll, T.; Kurcewicz, J.; Langer, C.; Le Bleis, T.; Leifels, Y.; Munzenberg, G.; Marganiec, J.; Nociforo, C.; Najafi, A.; Panin, V.; Paschalis, S.; Pietri, S.; Plag, R.; Rahaman, A.; Reifarth, R.; Ricciardi, V.; Rossi, D.; Ray, J.; Simon, H.; Scheidenberger, C.; Typel, S.; Taylor, J.; Togano, Y.; Volkov, V.; Weick, H.; Wagner, A.; Wamers, F.; Weigand, M.; Winfield, J.S.; Yakorev, D.; Zoric, M.

    2014-01-01

    Neutron-rich 34,35Al isotopes have been studied through Coulomb excitation using LAND-FRS setup at GSI, Darmstadt. The method of invariant mass analysis has been used to reconstruct the excitation energy of the nucleus prior to decay. Comparison of experimental CD cross-section with direct breakup

  4. First spatial separation of a heavy ion isomeric beam with amultiple-reflection time-of-flight mass spectrometer

    NARCIS (Netherlands)

    Dickel, T.; Plass, W. R.; Andres, S. Ayet San; Ebert, J.; Geissel, H.; Haettner, E.; Hornung, C.; Miskun, I.; Pietri, S.; Purushothaman, S.; Reiter, M. P.; Rink, A. -K.; Scheidenberger, C.; Weick, H.; Dendooven, P.; Diwisch, M.; Greiner, F.; Heisse, F.; Knoebel, R.; Lippert, W.; Moore, I. D.; Pohjalainen, I.; Prochazka, A.; Ranjan, M.; Takechi, M.; Winfield, J. S.; Xu, X.

    2015-01-01

    Po-211 ions in the ground and isomeric states were produced via U-238 projectile fragmentation at 1000 MeV/u. The Po-211 ions were spatially separated in flight from the primary beam and other reaction products by the fragment separator FRS. The ions were energy-bunched, slowed-down and thermalized

  5. First experimental results of a cryogenic stopping cell with short-lived, heavy uranium fragments produced at 1000 MeV/u

    NARCIS (Netherlands)

    Purushothaman, S.; Reiter, M. P.; Haettner, E.; Dendooven, P.; Dickel, T.; Geissel, H.; Ebert, J.; Jesch, C.; Plass, W. R.; Ranjan, M.; Weick, H.; Amjad, F.; Ayet, S.; Diwisch, M.; Estrade, A.; Farinon, F.; Greiner, F.; Kalantar-Nayestanaki, N.; Knoebel, R.; Kurcewicz, J.; Lang, J.; Moore, I. D.; Mukha, I.; Nociforo, C.; Petrick, M.; Pfuetzner, M.; Pietri, S.; Prochazka, A.; Rink, A. -K.; Rinta-Antila, S.; Scheidenberger, C.; Takechi, M.; Tanaka, Y. K.; Winfield, J. S.; Yavor, M. I.

    2013-01-01

    A cryogenic stopping cell (CSC) has been commissioned with U-238 projectile fragments produced at 1000 MeV/u. The spatial isotopic separation in flight was performed with the FRS applying a monoenergetic degrader. For the first time, a stopping cell was operated with exotic nuclei at cryogenic

  6. Rate capability of a cryogenic stopping cell for uranium projectile fragments produced at 1000 MeV/u

    Science.gov (United States)

    Reiter, M. P.; Rink, A.-K.; Dickel, T.; Haettner, E.; Heiße, F.; Plaß, W. R.; Purushothaman, S.; Amjad, F.; Ayet San Andrés, S.; Bergmann, J.; Blum, D.; Dendooven, P.; Diwisch, M.; Ebert, J.; Geissel, H.; Greiner, F.; Hornung, C.; Jesch, C.; Kalantar-Nayestanaki, N.; Knöbel, R.; Lang, J.; Lippert, W.; Miskun, I.; Moore, I. D.; Nociforo, C.; Petrick, M.; Pietri, S.; Pfützner, M.; Pohjalainen, I.; Prochazka, A.; Scheidenberger, C.; Takechi, M.; Tanaka, Y. K.; Weick, H.; Winfield, J. S.; Xu, X.

    2016-06-01

    At the Low-Energy Branch (LEB) of the Super-FRS at FAIR, projectile and fission fragments will be produced at relativistic energies, separated in-flight, energy-bunched, slowed down and thermalized in a cryogenic stopping cell (CSC) filled with ultra-pure He gas. The fragments are extracted from the stopping cell using a combination of DC and RF electric fields and gas flow. A prototype CSC for the LEB has been developed and successfully commissioned at the FRS Ion Catcher at GSI. Ionization of He buffer gas atoms during the stopping of energetic ions creates a region of high space charge in the stopping cell. The space charge decreases the extraction efficiency of stopping cells since the high amount of charge distorts the applied DC electric drag fields. Thus the understanding of space charge effects is of great importance to make full use of the high yields at future RIB facilities such as the Super-FRS at FAIR. For this purpose a detailed study of space charge effects in the CSC was performed using experiments and simulations. The dependence of the extraction efficiency, the extraction time and the temporal ion extraction profile on the intensity of the impinging beam and the electric field strength was studied for two different 238 U projectile fragments produced at 1000 MeV/u and separated with the FRS. Good agreement between experiments and simulations was found.

  7. Dermal bioaccessibility of flame retardants from indoor dust and the influence of topically applied cosmetics.

    Science.gov (United States)

    Pawar, Gopal; Abdallah, Mohamed Abou-Elwafa; de Sáa, Eugenia Villaverde; Harrad, Stuart

    2017-01-01

    Despite extensive literature on their potential adverse health effects, there is a lack of information on human dermal exposure to organic flame retardant chemicals (FRs). This study applies an in vitro physiologically based extraction test to provide new insights into the dermal bioaccessibility of various FRs from indoor dust to synthetic sweat/sebum mixture (SSSM). The bioaccessible fractions of α-, β- and γ-hexabromocyclododecane (HBCD) and tetrabromobisphenol A (TBBPA) to 1:1 (sweat/sebum) mixture were 41%, 47%, 50% and 40%, respectively. For Tris-2-chloroethyl phosphate (TCEP), tris (1-chloro-2-propyl) phosphate (TCIPP) and tris-1,3-dichloropropyl phosphate (TDCIPP), bioaccessible fractions were 10%, 17% and 19%. Composition of the SSSM and compound-specific physicochemical properties were the major factors influencing the bioaccessibility of target FRs. Except for TBBPA, the presence of cosmetics (moisturising cream, sunscreen lotion, body spray and shower gel) had a significant effect (Pcosmetics decreased the bioaccessibility of HBCDs from indoor dust, whereas shower gel and sunscreen lotion enhanced the bioaccessibility of target PFRs. Our bioaccessibility data were applied to estimate the internal exposure of UK adults and toddlers to the target FRs via dermal contact with dust. Our worst-case scenario exposure estimates fell far below available health-based limit values for TCEP, TCIPP and TDCIPP. However, future research may erode the margin of safety for these chemicals.

  8. Klein, Michael L

    Indian Academy of Sciences (India)

    Annual Meetings · Mid Year Meetings · Discussion Meetings · Public Lectures · Lecture Workshops · Refresher Courses · Symposia · Live Streaming. Home; Fellowship. Fellow Profile. Elected: 2006 Honorary. Klein, Michael L FRS. Date of birth: 1940. Address: Director, ICMS, Temple University, CST, SERC Building, 704E, ...

  9. Flame retardant emission from e-waste recycling operation in northern Vietnam: environmental occurrence of emerging organophosphorus esters used as alternatives for PBDEs.

    Science.gov (United States)

    Matsukami, Hidenori; Tue, Nguyen Minh; Suzuki, Go; Someya, Masayuki; Tuyen, Le Huu; Viet, Pham Hung; Takahashi, Shin; Tanabe, Shinsuke; Takigami, Hidetaka

    2015-05-01

    Three oligomeric organophosphorus flame retardants (o-PFRs), eight monomeric PFRs (m-PFRs), tetrabromobisphenol A (TBBPA), and polybrominated diphenyl ethers (PBDEs) were identified and quantified in surface soils and river sediments around the e-waste recycling area in Bui Dau, northern Vietnam. Around the e-waste recycling workshops, 1,3-phenylene bis(diphenyl phosphate) (PBDPP), bisphenol A bis(diphenyl phosphate) (BPA-BDPP), triphenyl phosphate (TPHP), TBBPA, and PBDEs were dominant among the investigated flame retardants (FRs). The respective concentrations of PBDPP, BPA-BDPP, TPHP, TBBPA and the total PBDEs were 6.6-14000 ng/g-dry, e-waste, tris(methylphenyl) phosphate (TMPP), (2-ethylhexyl)diphenyl phosphate (EHDPP), TPHP, and the total PBDEs were abundantly with respective concentrations of e-waste have been determined to be important factors contributing to the emissions of FRs. The environmental occurrence of emerging FRs, especially o-PFRs, indicates that the alternation of FRs addition in electronic products is shifting in response to domestic and international regulations of PBDEs. The emissions of alternatives from open storage and burning of e-waste might become greater than those of PBDEs in the following years. The presence and environmental effects of alternatives should be regarded as a risk factor along with e-waste recycling. Copyright © 2015 Elsevier B.V. All rights reserved.

  10. Users Manual for the Dynamic Student Flow Model.

    Science.gov (United States)

    1981-07-31

    VS41: S3A >( --- > (---) San Diego, CA --- >_ --- VR30: C9/CT39 >( --- > --- Alameda , CA __ >(--- MISCELLANEOUS >( )-> JET-FRS-NETWORK I. Figure 3.8...34Naval Flight Officer Training Rate" - Same type of breakdown as PTR and by pipeline - RIO , oJN, NAV, AEW/AELW/ATDS, etc. Node. See Network. "Non

  11. Solid State and Materials Chemistry

    Indian Academy of Sciences (India)

    Unknown

    It gives us immense pleasure to present this Special Issue of the Proceedings of the Indian. Academy of Sciences (Chemical Sciences) to mark the Silver Jubilee of the Solid State and Structural Chemistry Unit (SSCU), Indian Institute of Science, Bangalore. This Unit was created by Professor C N R Rao, FRS, at the Institute ...

  12. Bondi, Prof. Sir Hermann

    Indian Academy of Sciences (India)

    ... Public Lectures · Lecture Workshops · Refresher Courses · Symposia · Live Streaming. Home; Fellowship. Fellow Profile. Elected: 1997 Honorary. Bondi, Prof. Sir Hermann KCB, FRS. Date of birth: 1 November 1919. Date of death: 10 September 2005. Last known address: Fellow, Churchill College, Cambridge, CB3 0DS, ...

  13. Gopalan, Dr Coluthur

    Indian Academy of Sciences (India)

    ... and London), FNA, FAMS, FRS Council Service: 1968-70, 1977-79. Date of birth: 29 November 1918. Specialization: Nutrition and Medical Research Address: 39, Landon's Road, Kilpauk, Chennai 600 010, T.N.. Contact: Residence: (044) 4285 8842. Email: malini1seshadri@gmail.com. YouTube; Twitter; Facebook; Blog ...

  14. Geim, Prof. Sir Andre Konstantin

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2015 Honorary. Geim, Prof. Sir Andre Konstantin FRS. Date of birth: 21 October 1958. Address: Royal Society Research Professor, University of Manchester, Oxford Road, Manchester M13 9PL, UK Contact: Office: (+44-161) 275 4120. Email: geim@manchester.ac.uk. YouTube; Twitter; Facebook ...

  15. 75 FR 39669 - Privacy Act of 1974; System of Records

    Science.gov (United States)

    2010-07-12

    ... routine uses of the information in the altered system of records described in this notice, in accordance... call the Federal Relay Service (FRS) at 1-800-877-8339. SUPPLEMENTARY INFORMATION: Introduction The.... The information about each individual is called a ``record,'' and the system, whether manual or...

  16. Financial Health of the Higher Education Sector: 2015-16 to 2018-19 Forecasts. Data Analysis. November 2016/34

    Science.gov (United States)

    Higher Education Funding Council for England, 2016

    2016-01-01

    This report provides an overview of the forecast financial health of the HEFCE-funded higher education (HE) sector in England. The analysis covers the financial forecasts for the period 2015-16 to 2018-19, based on information submitted by higher education institutions (HEIs) to HEFCE in July 2016. Financial Reporting Standard (FRS) 102 is the new…

  17. First rank symptoms: concepts and diagnostic utility

    African Journals Online (AJOL)

    are associated with psychiatric presentations in the absence of clouding of consciousness such as head trauma, encephalitis, psychosis associated with Huntington's disorder, multiple sclerosis and various inter-ictal manifestations of epilepsy.21. Prognostic and diagnostic implications of FRS. The prognostic implications of ...

  18. High frequency oscillations and high frequency functional network characteristics in the intraoperative electrocorticogram in epilepsy

    NARCIS (Netherlands)

    Zweiphenning, W. J E M; van 't Klooster, M. A.; van Diessen, E.; van Klink, N. E C; Huiskamp, G. J M; Gebbink, T. A.; Leijten, F. S S; Gosselaar, P. H.; Otte, W. M.; Stam, C. J.; Braun, K. P J; Zijlmans, G. J M

    2016-01-01

    OBJECTIVE: High frequency oscillations (HFOs; > 80 Hz), especially fast ripples (FRs, 250-500 Hz), are novel biomarkers for epileptogenic tissue. The pathophysiology suggests enhanced functional connectivity within FR generating tissue. Our aim was to determine the relation between brain areas

  19. Fulltext PDF

    Indian Academy of Sciences (India)

    IAS Admin

    In the International Year of Statistics we would like to honour the following scientists who have had a profound impact on the research and practice of statistical science. Thomas Bayes (1702–1761), FRS, was a mathematician who introduced Bayesian infer- ence or inverse probability in statistics. Even though the Bayes ...

  20. High frequency oscillations and high frequency functional network characteristics in the intraoperative electrocorticogram in epilepsy.

    Science.gov (United States)

    Zweiphenning, W J E M; van 't Klooster, M A; van Diessen, E; van Klink, N E C; Huiskamp, G J M; Gebbink, T A; Leijten, F S S; Gosselaar, P H; Otte, W M; Stam, C J; Braun, K P J; Zijlmans, G J M

    2016-01-01

    High frequency oscillations (HFOs; > 80 Hz), especially fast ripples (FRs, 250-500 Hz), are novel biomarkers for epileptogenic tissue. The pathophysiology suggests enhanced functional connectivity within FR generating tissue. Our aim was to determine the relation between brain areas showing FRs and 'baseline' functional connectivity within EEG networks, especially in the high frequency bands. We marked FRs, ripples (80-250 Hz) and spikes in the electrocorticogram of 14 patients with refractory temporal lobe epilepsy. We assessed 'baseline' functional connectivity in epochs free of epileptiform events within these recordings, using the phase lag index. We computed the Eigenvector Centrality (EC) per channel in the FR and gamma band network. We compared EC between channels that did or did not show events at other moments in time. FR-band EC was higher in channels with than without spikes. Gamma-band EC was lower in channels with ripples and FRs. We confirmed previous findings of functional isolation in the gamma-band and found a first proof of functional integration in the FR-band network of channels covering presumed epileptogenic tissue. 'Baseline' high-frequency network parameters might help intra-operative recognition of epileptogenic tissue without the need for waiting for events. These findings can increase our understanding of the 'architecture' of epileptogenic networks and help unravel the pathophysiology of HFOs.

  1. Experiment list: SRX019933 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ,6.1,724 GSM529979: MDEC DMSO-preexposed rep2 [ChIP-seq] source_name=mammosphere-derived epithelial cells fr...s (MDECs) || protocol=DMSO-preexposed || chip antibody=RNA Polymerase II (Santa C

  2. Synthesis and characterization of folate-poly(ethylene glycol ...

    African Journals Online (AJOL)

    polyethylenimine as a non-viral carrier for tumor-targeted gene delivery. ... It was concluded that FA-PEG-CHI-g-PEI, which has improved transfection efficiency and FRs specificity in vitro and in vivo, may be useful in gene therapy. Key words: Folate ...

  3. A photoelectrochemical immunosensor for detection of α-fetoprotein based on Au-ZnO flower-rod heterostructures

    Science.gov (United States)

    Han, Zhizhong; Luo, Min; Chen, Li; Chen, Jinghua; Li, Chunyan

    2017-04-01

    In this work, a novel label free photoelectrochemical (PEC) immunosensor has been developed for the detection of α-fetoprotein (AFP). The immunosensor was based on Au-ZnO flower-rods (FRs) heterostructure, where Au nanoparticles (NPs) were firstly electrodeposited by cyclic voltammetry methods. Scanning electron microscopy (SEM), X-ray diffraction (XRD), Mott-Schottky plot (MS), UV-vis diffuse reflectance spectrum and fluorescence emission spectrum were used for the characterizations of Au-ZnO FRs. The results demonstrated that Au NPs not only obviously enhanced the visible light absorption of ZnO FRs due to surface plasmon resonance (SPR) but also improved the separation of photo-generated electron-hole pairs. Therefore, the photocurrent of Au-ZnO FRs was increased under simulated sunlight. The photocurrent was reduced after the specific antibody-antigen immune reaction. And the photocurrent decrement was linear with the logarithm of AFP antigen concentration in the range from 0.005 ng mL-1 to 50 ng mL-1 with a low detection limit of 0.56 pg mL-1 (S/N = 3). The PEC immunosensor also exhibited high anti-interference property and acceptable stability. This work would provide a promising photoelectrochemical strategy for the detection of other proteins in clinical diagnosis.

  4. Effect of urea additive on the thermal decomposition kinetics of flame retardant greige cotton nonwoven fabric

    Science.gov (United States)

    Sunghyun Nam; Brian D. Condon; Robert H. White; Qi Zhao; Fei Yao; Michael Santiago Cintrón

    2012-01-01

    Urea is well known to have a synergistic action with phosphorus-based flame retardants (FRs) in enhancing the FR performance of cellulosic materials, but the effect of urea on the thermal decomposition kinetics has not been thoroughly studied. In this study, the activation energy (Ea) for the thermal decomposition of greige...

  5. PROTEKSI MINYAK IKAN LEMURU, MINYAK KELAPA SAWIT, DAN BUNGKIL SAWIT TERHADAP pH DAN NH3DALAM RUMEN SAPI PERANAKAN ONGOLE

    Directory of Open Access Journals (Sweden)

    Catur Suci Purwati

    2016-03-01

    Full Text Available The aimed of this research is to know the influence of protection lemuru oil, palm oil, and palm oil cake to pH and NH3in the rumen of the Ongole. The material were used in this study werecomulated rumenfemale cows with average body weight of 289.33 ± 28.34 kg as many as 3 heads. Latin square experiment design was applied on 3 treatments. Fermented rice straw (FRS, basal concentrate (BC, and protected materials of Indian sardine oil (ISO, palm oil (PO, and palmkernel cake (PKC were used as a feed ingredient.  Treatments were: P1 = FRS 40% + BC 60% (BC 95% + PO 5%; P2 = FRS 40% + BC 60% (BC 95% + ISO 5% ; P3 = FRS 40% + BC 60% (BC 90% + PKC 10%. Parameters measured were pH and NH3. Latin square experiment design was applied on 3 treatments.Conclusions of this study are pH and NH3remain stable, meaning lemuru addition of fish oil, palm oil, and palm oil cake is protected not disturb the digestive process in the cow rumen fistulated onggole breedparticular. (Key word: Indian sardine oil, NH3, Palm kernel cake, Palm oil, pH, Protection

  6. Evaluation and Optimization of Godare Starch as a Binder and ...

    African Journals Online (AJOL)

    The binding and disintegrating properties of Godare (Colcosia esculenta) starch in paracetamol tablet formulations were evaluated in comparison with potato starch. Tablet crushing strengths (Hs), friabilities Frs), disintegration times (DTs) and porosities were determined. The results showed that Godare starch has a better ...

  7. 75 FR 12226 - Privacy Act of 1974; Computer Matching Program

    Science.gov (United States)

    2010-03-15

    ...; the Academic Competitiveness Grant Program; the National Science and Mathematics Access to Retain... (FRS), toll free, at 1-800-877-8339. Individuals with disabilities can obtain this document in an... person listed in the preceding paragraph. Electronic Access to This Document You can view this document...

  8. 75 FR 66831 - Program Integrity Issues

    Science.gov (United States)

    2010-10-29

    ... Education (TEACH) Grant Program in part 686, the Federal Pell Grant Program, and the Academic... on satisfactory academic progress, Marty Guthrie or Marianna Deeken. Telephone: (202) 219-7031 or via... (FRS), toll free, at 1-800-877-8339. Individuals with disabilities can obtain this document in an...

  9. Special Issue on Theoretical Chemistry/Chemical Dynamics

    Indian Academy of Sciences (India)

    2017-07-02

    Jul 2, 2017 ... This month's issue of the Journal of Chemical Sciences honours Professor Charusita Chakravarty, who has made immeasurable contributions to theoretical chemistry and chemical dynamics. The editors Biman Bagchi (FASc, FNA, FTWAS; Indian Institute of Science, Bangalore, India), David Clary (FRS; ...

  10. Page 1 192 PKSen and SV Weeravalli entire range of unstable cyt is ...

    Indian Academy of Sciences (India)

    As a final word in conclusion, it may be stated that the present work keeps alive the question of a possible connection between stability theory and actual turbulence, in Wall- bounded turbulent flows. 7. Dedication. We wish to dedicate this paper to Professor Peter Bradshaw FRS (somewhat belatedly) on the occasion of his ...

  11. Schmidt, Prof. Brian P

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2014 Honorary. Schmidt, Prof. Brian P Nobel Laureate (Physics), FRS. Date of birth: 24 February 1967. Address: Vice Chancellor, The Australian National University, via Cotter Road, Weston Creek, ACT 2611, Australia Contact: Office: (+61-2) 6125 2510. Fax: (+61-2) 6125 0260

  12. Cheetham, Prof. Antony Kevin

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2001 Honorary. Cheetham, Prof. Antony Kevin FRS. Date of birth: 16 November 1946. Address: Dept. of Materials Science &, Metallurgy, University of Cambridge, 27, Charles Babbage Road, Cambridge CB3 0FS, uk. Contact: Office: (+44-1223) 74 6733. Fax: (+44-1223) 33 4567

  13. Subjective Ratings of Annoyance Produced by Rotary-Wing Aircraft Noise

    Science.gov (United States)

    1977-05-01

    nov "is ossoLaTa Unclassified SECURITY CLASSFICATION 5.Frs PARE FW- D Eneredt- 𔃻 5 7 W Unclassified 69CURITY CLASIFICATION OF THIS PAG9(Vhw Da...paths followed during the various maneuvers relative to the location of the observers rendering the ratings. The observers were 25 adults hired on a

  14. Energy dependence of 238U fission yields investigated in inverse kinematics

    Directory of Open Access Journals (Sweden)

    Veselsky M.

    2010-03-01

    Full Text Available The production cross sections of neutron-rich fission residues produced in reactions induced by a 238U beam impinging onto Pb and Be targets were investigated at the Fragment Separator (FRS at GSI using the inverse kinematic technique. These data allowed us to discuss the optimum energies in fission for producing the most neutron-rich residues.

  15. Cardiovascular risk prediction in chronic kidney disease patients.

    Science.gov (United States)

    Cedeño Mora, Santiago; Goicoechea, Marian; Torres, Esther; Verdalles, Úrsula; Pérez de José, Ana; Verde, Eduardo; García de Vinuesa, Soledad; Luño, José

    Scores underestimate the prediction of cardiovascular risk (CVR) as they are not validated in patients with chronic kidney disease (CKD). Two of the most commonly used scores are the Framingham Risk Score (FRS-CVD) and the ASCVD (AHA/ACC 2013). The aim of this study is to evaluate the predictive ability of experiencing a cardiovascular event (CVE) via these 2scores in the CKD population. Prospective, observational study of 400 prevalent patients with CKD (stages 4 and 5 according the KDOQI; not on dialysis). Cardiovascular risk was calculated according to the 2scores and the predictive capacity of cardiovascular events (atherosclerotic events: myocardial infarction, ischaemic and haemorrhagic stroke, peripheral vascular disease; and non-atherosclerotic events: heart failure) was analysed. Forty-nine atherosclerotic cardiovascular events occurred in 40.3±6.6 months of follow-up. Most of the patients were classified as high CVR by both scores (59% by the FRS-CVD and 75% by the ASCVD). All cardiovascular events occurred in the high CVR patients and both scores (FRS-CVD log-rank 12.2, Prenal function, albuminuria and previous cardiovascular events. The cardiovascular risk scores (FRS-CVD and ASCVD [AHA/ACC 2013]) can estimate the probability of atherosclerotic cardiovascular events in patients with CKD regardless of renal function, albuminuria and previous cardiovascular events. Copyright © 2016 Sociedad Española de Nefrología. Published by Elsevier España, S.L.U. All rights reserved.

  16. an assessment of household energy types, sources, uses and its ...

    African Journals Online (AJOL)

    xtz

    household expenditure on the various energy types/sources for the study area was evaluated at about. 10496640 FRS CFA (US$ 20993). ... the household income expenditure patterns and domestic energy demands (Kantai 2002). .... Molyko II, which is a student residential area, was observed to depend solely on electrical ...

  17. After the PBDE phase-out: a broad suite of flame retardants in repeat house dust samples from California.

    Science.gov (United States)

    Dodson, Robin E; Perovich, Laura J; Covaci, Adrian; Van den Eede, Nele; Ionas, Alin C; Dirtu, Alin C; Brody, Julia Green; Rudel, Ruthann A

    2012-12-18

    Higher house dust levels of PBDE flame retardants (FRs) have been reported in California than other parts of the world, due to the state's furniture flammability standard. However, changing levels of these and other FRs have not been evaluated following the 2004 U.S. phase-out of PentaBDE and OctaBDE. We analyzed dust collected in 16 California homes in 2006 and again in 2011 for 62 FRs and organohalogens, which represents the broadest investigation of FRs in homes. Fifty-five compounds were detected in at least one sample; 41 in at least 50% of samples. Concentrations of chlorinated OPFRs, including two (TCEP and TDCIPP) listed as carcinogens under California's Proposition 65, were found up to 0.01% in dust, higher than previously reported in the U.S. In 75% of the homes, we detected TDBPP, or brominated "Tris," which was banned in children's sleepwear because of carcinogenicity. To our knowledge, this is the first report on TDBPP in house dust. Concentrations of Firemaster 550 components (EH-TBB, BEH-TEBP, and TPHP) were higher in 2011 than 2006, consistent with its use as a PentaBDE replacement. Results highlight the evolving nature of FR exposures and suggest that manufacturers continue to use hazardous chemicals and replace chemicals of concern with chemicals with uncharacterized toxicity.

  18. Fisher, Prof. Michael Ellis

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2001 Honorary. Fisher, Prof. Michael Ellis FRS. Date of birth: 3 September 1931. Address: Distinguished Professor Emeritus, Institute of Physical Science and, Technology, University of Maryland, College Park, MD 20742-2431, U.S.A.. Contact: Office: (+1-301) 405 4819

  19. Comprehensive characterisation of flame retardants in textile furnishings by ambient high resolution mass spectrometry, gas chromatography-mass spectrometry and environmental forensic microscopy.

    Science.gov (United States)

    Ionas, Alin C; Ballesteros Gómez, Ana; Uchida, Natsuyo; Suzuki, Go; Kajiwara, Natsuko; Takata, Kyoko; Takigami, Hidetaka; Leonards, Pim E G; Covaci, Adrian

    2015-10-01

    The presence and levels of flame retardants (FRs), such as polybrominated diphenyl ethers (PBDEs) and organophosphate flame retardants (PFRs), was determined in textile home furnishings, such as carpets and curtains from stores in Belgium. A comprehensive characterisation of FRs in textile was done by ambient high resolution mass spectrometry (qualitative screening), gas chromatography-mass spectrometry (GC-MS) (quantitation), and environmental forensic microscopy (surface distribution). Ambient ionisation coupled to a time-of-flight (TOF) high resolution mass spectrometer (direct probe-TOF-MS) was investigated for the rapid screening of FRs. Direct probe-TOF-MS proved to be useful for a first screening step of textiles to detect FRs below the levels required to impart flame retardancy and to reduce, in this way, the number of samples for further quantitative analysis. Samples were analysed by GC-MS to confirm the results obtained by ambient mass spectrometry and to obtain quantitative information. The levels of PBDEs and PFRs were typically too low to impart flame retardancy. Only high levels of BDE-209 (11-18% by weight) were discovered and investigated in localised hotspots by employing forensic microscopy techniques. Most of the samples were made of polymeric materials known to be inherently flame retarded to some extent, so it is likely that other alternative and halogen-free FR treatments/solutions are preferred for the textiles on the Belgian market. Copyright © 2015 Elsevier Inc. All rights reserved.

  20. All Are Worthy to Know the Earth: Henry De la Beche and the Origin of Geological Literacy

    Science.gov (United States)

    Clary, Renee M.; Wandersee, James H.

    2009-01-01

    Henry T. De la Beche (1796-1855) began his geological career within an elite circle (Geological Society of London, 1817; FRS, 1819), collaborating with influential gentlemen geologists and publishing original research. When his independent income dwindled, De la Beche managed to secure governmental funding for his mapping projects. This led to…

  1. Association of relatives of hemodialysis patients with metabolic syndrome, albuminuria and Framingham Risk Score.

    Directory of Open Access Journals (Sweden)

    Jiun-Chi Huang

    Full Text Available BACKGROUND AND AIM: Metabolic syndrome (MetS, albuminuria, and the Framingham Risk Score (FRS are significant predictors for cardiovascular disease (CVD. However, the relationship and clinical significance of these CVD predictors in individuals with a family history of end-stage renal disease (ESRD are unclear. We investigated the association of relatives of hemodialysis (HD patients with MetS, albuminuria, and the FRS. METHODS: One hundred and sixty-six relatives of HD patients and 374 age- and sex- matched community controls were enrolled. MetS was defined using the Adult Treatment Panel III for Asians. Albuminuria was defined as urine albumin-to-creatinine ratio ≥ 30 mg/g. CVD risk was evaluated by the FRS. RESULTS: A significantly higher prevalence of MetS (19.9% vs. 12.5%, P = 0.026, albuminuria (12.7% vs. 5.1%, P = 0.002 and high FRS risk ≥ 10% of 10-year risk (15.7% vs. 8.5%, P = 0.013 was found in relatives of HD patients compared to their counterpart controls. In multivariate analysis, being relatives of HD patients (vs. controls was an independent determinant for MetS (odds ratio [OR], 1.785; 95% confidence interval [CI], 1.045 to 3.050, albuminuria (OR, 2.891; 95% CI, 1.431 to 5.841, and high FRS risk (OR, 1.863; 95% CI, 1.015 to 3.418. Higher low-density lipoprotein cholesterol (OR, 1.034; 95% CI, 1.017 to 1.052 and betel nut chewing (OR, 13.994; 95% CI, 3.384 to 57.871 were independent determinants for having a high FRS risk in relatives of HD patients. CONCLUSIONS: Being relatives of HD patients was independently associated with MetS, albuminuria and high FRS risk, suggesting family members of ESRD patients may have higher CVD risks through the interactions of renal risk factors. Proactive surveillance of these CVD predictors and preventive strategies should be targeted to this high-risk population.

  2. Framingham risk score and severity of coronary artery disease.

    Science.gov (United States)

    Sayin, M R; Cetiner, M A; Karabag, T; Akpinar, I; Sayin, E; Kurcer, M A; Dogan, S M; Aydin, M

    2014-08-01

    Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Easy-to-perform and reliable parameters are needed to predict the presence and severity of CAD and to implement efficient diagnostic and therapeutic modalities. We aimed to examine whether the Framingham risk scoring system can be used for this purpose. A total of 222 patients (96 women, 126 men; mean age, 59.1 ± 11.9 years) who underwent coronary angiography were enrolled in the study. Presence of > %50 stenosis in a coronary artery was assessed as critical CAD. The Framingham risk score (FRS) was calculated for each patient. CAD severity was assessed by the Gensini score. The relationship between the FRS and the Gensini score was analyzed by correlation and regression analyses. The mean Gensini score was 18.9 ± 25.8, the median Gensini score was 7.5 (0-172), the mean FRS was 7.7 ± 4.2, and the median FRS was 7 (0-21). Correlation analysis revealed a significant relationship between FRS and Gensini score (r = 0.432, p < 0.0001). This relationship was confirmed by linear regression analysis (β = 0.341, p < 0.0001). A cut-off level of 7.5 for FRS predicted severe CAD with a sensitivity of 68 % and a specificity of 73.6 % (ROC area under curve: 0.776, 95 % CI: 0.706-0.845, PPV: 78.1 %, NPV: 62.3 %, p < 0.0001). Our work suggests that the FRS system is a simple and feasible method that can be used for prediction of CAD severity. As the sample size was small in our study, further large-scale studies are needed on this subject to draw solid conclusions.

  3. Dynamic changes in spectral and spatial signatures of high frequency oscillations in rat hippocampi during epileptogenesis in acute and chronic stages

    Directory of Open Access Journals (Sweden)

    Pan-Pan Song

    2016-11-01

    Full Text Available Objective: To analyze spectral and spatial signatures of high frequency oscillations (HFOs, which include ripples and fast ripples (FRs, > 200 Hz by quantitatively assessing average and peak spectral power in a rat model of different stages of epileptogenesis.Methods: The lithium–pilocarpine model of temporal lobe epilepsy was used. The acute phase of epilepsy was assessed by recording intracranial electroencephalography (EEG activity for 1 day after status epilepticus (SE. The chronic phase of epilepsy, including spontaneous recurrent seizures (SRSs, was assessed by recording EEG activity for 28 days after SE. Average and peak spectral power of five frequency bands of EEG signals in CA1, CA3 and DG regions of the hippocampus were analyzed with wavelet and digital filter.Results: FRs occurred in the hippocampus in the animal model. Significant dynamic changes in the spectral power of FRS were identified in CA1 and CA3. The average spectral power of ripples increased at 20 min before SE (p < 0.05, peaked at 10 min before diazepam injection. It decreased at 10 min after diazepam (p < 0.05 and returned to baseline after 1 hour (h. The average spectral power of FRs increased at 30 min before SE (p < 0.05 and peaked at 10 min before diazepam. It decreased at 10 min after diazepam (p < 0.05 and returned to baseline at 2 h after injection. The dynamic changes were similar between average and peak spectral power of FRs. Average and peak spectral power of both ripples and FRs in the chronic phase showed a gradual downward trend compared with normal rats 14 days after SE.Significance: The spectral power of HFOs may be utilized to distinguish between normal and pathologic HFOs. Ictal average and peak spectral power of FRs were two parameters for predicting acute epileptic seizures, which could be used as a new quantitative biomarker and early warning marker of seizure. Changes in interictal HFOs power in the hippocampus at the chronic stage may be not

  4. Performance of the Framingham risk score in patients receiving hemodialysis.

    Science.gov (United States)

    Huang, Jiun-Chi; Chen, Szu-Chia; Su, Ho-Ming; Chang, Jer-Ming; Hwang, Shang-Jyh; Chen, Hung-Chun

    2013-07-01

    The Framingham Risk Score (FRS), calculated by considering conventional risk factors of cardiovascular diseases, was developed to predict coronary heart disease in various populations. However, reverse epidemiology has been raised concerning these risk factors in predicting high cardiovascular mortality in hemodialysis patients. Our objectives are to determine whether FRS is associated with overall and cardiovascular mortality and the role of new risk markers when they were added to a FRS model in hemodialysis patients. This study enrolled 201 hemodialysis patients aged 20-80 years old. The FRS is used to identify individuals categorized as low (20% risk). Medical records were reviewed to collect clinical information. Data of ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) were obtained by an ABI-form device. The mean follow-up period was 4.4 ± 1.5 years. Intermediate risk predicted overall hazard ratio (HR) (2.157, P = 0.039) and cardiovascular mortality (HR= 5.023; P = 0.004) versus low risk, but 'high' risk did not. High risk (vs low risk) predicted cardiovascular events (HR = 2.458, P = 0.05). Besides, the addition of ABI hemodialysis patients, intermediate risk but not high risk categorization by FRS predicted overall and cardiovascular mortality, and high risk predicted cardiovascular events. ABI hemodialysis-specific equations and assess whether risk refinement using ABI < 0.9 and baPWV leads to a meaningful change in clinical outcomes. © 2013 The Authors. Nephrology © 2013 Asian Pacific Society of Nephrology.

  5. Physical–chemical properties and evaluative fate modelling of ‘emerging’ and ‘novel’ brominated and organophosphorus flame retardants in the indoor and outdoor environment

    Energy Technology Data Exchange (ETDEWEB)

    Liagkouridis, Ioannis, E-mail: ioannis.liagkouridis@aces.su.se [Department of Environmental Science and Analytical Chemistry (ACES), Stockholm University, SE 106 91 Stockholm (Sweden); IVL Swedish Environmental Research Institute, P.O. Box 21060, SE 100 31 Stockholm (Sweden); Cousins, Anna Palm [IVL Swedish Environmental Research Institute, P.O. Box 21060, SE 100 31 Stockholm (Sweden); Cousins, Ian T. [Department of Environmental Science and Analytical Chemistry (ACES), Stockholm University, SE 106 91 Stockholm (Sweden)

    2015-08-15

    Several groups of flame retardants (FRs) have entered the market in recent years as replacements for polybrominated diphenyl ethers (PBDEs), but little is known about their physical–chemical properties or their environmental transport and fate. Here we make best estimates of the physical–chemical properties and undertake evaluative modelling assessments (indoors and outdoors) for 35 so-called ‘novel’ and ‘emerging’ brominated flame retardants (BFRs) and 22 organophosphorus flame retardants (OPFRs). A QSPR (Quantitative Structure-Property Relationship) based technique is used to reduce uncertainty in physical–chemical properties and to aid property selection for modelling, but it is evident that more, high quality property data are required for improving future assessments. Evaluative modelling results show that many of the alternative FRs, mainly alternative BFRs and some of the halogenated OPFRs, behave similarly to the PBDEs both indoors and outdoors. These alternative FRs exhibit high overall persistence (P{sub ov}), long-range transport potential (LRTP) and POP-like behaviour and on that basis cannot be regarded as suitable replacements to PBDEs. A group of low molecular weight alternative BFRs and non-halogenated OPFRs show a potentially better environmental performance based on P{sub ov} and LRTP metrics. Results must be interpreted with caution though since there are significant uncertainties and limited data to allow for thorough model evaluation. Additional environmental parameters such as toxicity and bioaccumulative potential as well as functionality issues should be considered in an industrial substitution strategy. - Highlights: • ‘Best-estimates’ of physical–chemical properties of alternative FRs are proposed. • The ‘SMURF’ model and the OECD ‘The Tool’ are used to estimate the environmental fate. • Many alternative BFRs and HOPFRs have similar environmental fate to PBDEs. • Among alternative FRs, certain low MW

  6. Evaluation of Floor Response Spectrum considering Ductility of Structure

    Energy Technology Data Exchange (ETDEWEB)

    Park, Junhee; Choi, In-Kil [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-10-15

    The FRS (floor response spectrum) is directly influenced by the behavior of structure under the seismic load. If the structure is nonlinear range, the energy dissipation will be occurred by the damage of structure and the maximum force will be reduced. In Zion method, the inelastic energy abortion factor has been used to consider the nonlinearity of structure. This factor was used for the seismic fragility of structure. For the seismic fragility of equipment, the uncertainty of this factor was used differently according to the story level. But this method is not warranted under the strong earthquake leads to the structural damage. Therefore it is needed to evaluate the FRS considering the nonlinear behavior of structure and to assessment the conservatism related to nonlinear behavior of structure in FRS. In this study, the nonlinear analysis was performed for the conservatism of FRS under the damage of structure. The conservatism of FRS by the nonlinear analysis was compared by that proposed by the Zion method. The conservatism of floor acceleration response for the equipment was evaluated by performing the nonlinear analysis. From the nonlinear analysis results, it was showed that the median and β{sub c} of FRSR was increased with the ductility of structure and the response of equipment had the resonance effect between the frequency of equipment and structure. The seismic capacity of equipment by the Zion method can be different from the real seismic capacity of equipment because the inelastic structure response factor has nothing to do with the ductility of structure. Therefore the median and COV for FRSR should be defined considering the ductility of structure and the frequency of equipment for more exactly evaluating the seismic capacity of equipment.

  7. Association between Knee Osteoarthritis, Cardiovascular Risk Factors, and the Framingham Risk Score in South Koreans: A Cross-Sectional Study.

    Directory of Open Access Journals (Sweden)

    Ho Sun Kim

    Full Text Available Osteoarthritis is a significant burden on personal health and for social cost, and its prevalence is rising. Recent research has revealed an association between osteoarthritis and cardiovascular disease, and this study uses the Framingham risk score (FRS, which is widely used as a composite index of cardiovascular risk factors, to investigate the association between osteoarthritis and various cardiovascular risk factors.A total 9,514 participants aged 50 years or older who received knee X-ray diagnosis of the 5th Korean National Health and Nutrition Examination Survey (total surveyees = 24,173 released by the Korean Centers for Disease Control and Prevention was included for analysis. Knee osteoarthritis patients were defined as participants with K-L grade ≥2 on knee X-ray regardless of knee pain. The association between major cardiovascular risk factors (blood pressure, diabetes, cholesterol, and smoking habits, FRS, and knee osteoarthritis was analyzed, adjusting for various covariates.Prevalence of knee osteoarthritis in Koreans aged ≥50 years was 36.6%, and higher in women (men: 24.9%, women: 45.4%. Prevalence of knee osteoarthritis in participants with hypertension was significantly higher than those without hypertension (fully adjusted odds ratio (OR 1.26; 95% confidence interval (CI 1.08-1.48. Knee osteoarthritis prevalence was also higher in participants with impaired fasting glucose or diabetes than those without (age, sex adjusted OR 1.19; 95% CI 1.00-1.41. Also, OR values increased statistically significantly with FRS as a continuous variable (fully adjusted OR 1.007; 95% CI 1.00-1.01.Prevalence of knee osteoarthritis was associated with hypertension and diabetes, which are major cardiovascular risk factors, and the FRS. Further studies on FRS pertaining to its relationship with osteoarthritis are warranted.

  8. Characterization and cytotoxic activity of sulfated derivatives of polysaccharides from Agaricus brasiliensis

    Science.gov (United States)

    Cardozo, F. T. G. S.; Camelini, C. M.; Cordeiro, M. N. S.; Mascarello, A.; Malagoli, B. G.; Larsen, I.; Rossi, M. J.; Nunes, R. J.; Braga, F. C.; Brandt, C.R.; Simões, C. M. O.

    2014-01-01

    Agaricus brasiliensis cell-wall polysaccharides isolated from fruiting body (FR) and mycelium (MI) and their respective sulfated derivatives (FR-S and MI-S) were chemically characterized using elemental analysis, TLC, FT-IR, NMR, HPLC, and thermal analysis. Cytotoxic activity was evaluated against A549 tumor cells by MTT and sulforhodamine assays. The average molecular weight (Mw) of FR and MI was estimated to be 609 and 310 kDa, respectively. FR-S (127 kDa) and MI-S (86 kDa) had lower Mw, probably due to hydrolysis occurred during the sulfation reaction. FR-S and MI-S presented ~14 % sulfur content in elemental analysis. Sulfation of samples was characterized by the appearance of two new absorption bands at 1253 and 810 cm−1 in the infrared spectra, related to S=O and C-S-O sulfate groups, respectively. Through 1H and 13C NMR analysis FR-S was characterized as a (1→6)-(1→3)-β-D-glucan fully sulfated at C-4 and C-6 terminal and partially sulfated at C-6 of (1→3)-β-D-glucan moiety. MI-S was shown to be a (1→3)-β-D-gluco-(1→2)-β-D-mannan, partially sulfated at C-2, C-3, C-4, and C-6, and fully sulfated at C-6 of the terminal residues. The combination of high degree of sulfation and low molecular weight was correlated with the increased cytotoxic activity (48 h of treatment) of both FR-S (EC50=605.6 μg/mL) and MI-S (EC50=342.1 μg/mL) compared to the non-sulfated polysaccharides FR and MI (EC50>1500 μg/mL). PMID:23511057

  9. Effluent Free Radicals are Associated with Residual Renal Function and Predict Technique Failure in Peritoneal Dialysis Patients

    Science.gov (United States)

    Morinaga, Hiroshi; Sugiyama, Hitoshi; Inoue, Tatsuyuki; Takiue, Keiichi; Kikumoto, Yoko; Kitagawa, Masashi; Akagi, Shigeru; Nakao, Kazushi; Maeshima, Yohei; Miyazaki, Ikuko; Asanuma, Masato; Hiramatsu, Makoto; Makino, Hirofumi

    2012-01-01

    ♦ Objective: Residual renal function (RRF) is associated with low oxidative stress in peritoneal dialysis (PD). In the present study, we investigated the relationship between the impact of oxidative stress on RRF and patient outcomes during PD. ♦ Methods: Levels of free radicals (FRs) in effluent from the overnight dwell in 45 outpatients were determined by electron spin resonance spectrometry. The FR levels, clinical parameters, and the level of 8-hydroxy-2′-deoxyguanosine were evaluated at study start. The effects of effluent FR level on technique and patient survival were analyzed in a prospective cohort followed for 24 months. ♦ Results: Levels of effluent FRs showed significant negative correlations with daily urine volume and residual renal Kt/V, and positive correlations with plasma β2-microglobulin and effluent 8-hydroxy-2′-deoxyguanosine. A highly significant difference in technique survival (p < 0.05), but not patient survival, was observed for patients grouped by effluent FR quartile. The effluent FR level was independently associated with technique failure after adjusting for patient age, history of cardiovascular disease, and presence of diabetes mellitus (p < 0.001). The level of effluent FRs was associated with death-censored technique failure in both univariate (p < 0.001) and multivariate (p < 0.01) hazard models. Compared with patients remaining on PD, those withdrawn from the modality had significantly higher levels of effluent FRs (p < 0.005). ♦ Conclusions: Elevated effluent FRs are associated with RRF and technique failure in stable PD patients. These findings highlight the importance of oxidative stress as an unfavorable prognostic factor in PD and emphasize that steps should be taken to minimize oxidative stress in these patients. PMID:22215657

  10. Formulation, release characteristics, and bioavailability study of gastroretentive floating matrix tablet and floating raft system of Mebeverine HCl.

    Science.gov (United States)

    El Nabarawi, Mohamed A; Teaima, Mahmoud H; Abd El-Monem, Rehab A; El Nabarawy, Nagla A; Gaber, Dalia A

    2017-01-01

    To prolong the residence time of dosage forms within the gastrointestinal tract until all drug is released at the desired rate is one of the real challenges for oral controlled-release drug delivery systems. This study was designed to develop a controlled-release floating matrix tablet and floating raft system of Mebeverine HCl (MbH) and evaluate different excipients for their floating behavior and in vitro controlled-release profiles. Oral pharmacokinetics of the optimum matrix tablet, raft system formula, and marketed Duspatalin® 200 mg retard as reference were studied in beagle dogs. The optimized tablet formula (FT-10) and raft system formula (FRS-11) were found to float within 34±5 sec and 15±7 sec, respectively, and both remain buoyant over a period of 12 h in simulated gastric fluid. FT-10 (Compritol/HPMC K100M 1:1) showed the slowest drug release among all prepared tablet formulations, releasing about 80.2% of MbH over 8 h. In contrast, FRS-11 (Sodium alginate 3%/HPMC K100M 1%/Precirol 2%) had the greatest retardation, providing sustained release of 82.1% within 8 h. Compared with the marketed MbH product, the Cmax of FT-10 was almost the same, while FRS-11 maximum concentration was higher. The tmax was 3.33, 2.167, and 3.0 h for marketed MbH product, FT-10, and FRS-11, respectively. In addition, the oral bioavailability experiment showed that the relative bioavailability of the MbH was 104.76 and 116.01% after oral administration of FT-10 and FRS-11, respectively, compared to marketed product. These results demonstrated that both controlled-released floating matrix tablet and raft system would be promising gastroretentive delivery systems for prolonging drug action.

  11. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for rapid identification of fungal rhinosinusitis pathogens.

    Science.gov (United States)

    Huang, Yanfei; Wang, Jinglin; Zhang, Mingxin; Zhu, Min; Wang, Mei; Sun, Yufeng; Gu, Haitong; Cao, Jingjing; Li, Xue; Zhang, Shaoya; Lu, Xinxin

    2017-03-01

    Filamentous fungi are among the most important pathogens, causing fungal rhinosinusitis (FRS). Current laboratory diagnosis of FRS pathogens mainly relies on phenotypic identification by culture and microscopic examination, which is time consuming and expertise dependent. Although matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) MS has been employed to identify various fungi, its efficacy in the identification of FRS fungi is less clear. A total of 153 FRS isolates obtained from patients were analysed at the Clinical Laboratory at the Beijing Tongren Hospital affiliated to the Capital Medical University, between January 2014 and December 2015. They were identified by traditional phenotypic methods and Bruker MALDI-TOF MS (Bruker, Biotyper version 3.1), respectively. Discrepancies between the two methods were further validated by sequencing. Among the 153 isolates, 151 had correct species identification using MALDI-TOF MS (Bruker, Biot 3.1, score ≥2.0 or 2.3). MALDI-TOF MS enabled identification of some very closely related species that were indistinguishable by conventional phenotypic methods, including 1/10 Aspergillus versicolor, 3/20 Aspergillus flavus, 2/30 Aspergillus fumigatus and 1/20 Aspergillus terreus, which were misidentified by conventional phenotypic methods as Aspergillus nidulans, Aspergillus oryzae, Aspergillus japonicus and Aspergillus nidulans, respectively. In addition, 2/2 Rhizopus oryzae and 1/1 Rhizopus stolonifer that were identified only to the genus level by the phenotypic method were correctly identified by MALDI-TOF MS. MALDI-TOF MS is a rapid and accurate technique, and could replace the conventional phenotypic method for routine identification of FRS fungi in clinical microbiology laboratories.

  12. [The foundation of the German Society for Child Psychiatry and Therapeutic Education – Paul Schroeder’s road to foundation chairman].

    Science.gov (United States)

    Schepker, Klaus; Fangerau, Heiner

    2016-01-01

    The reconstruction of the evolutionary history of this professional association lays its focus on the developments which contributed to the society’s formal foundation during the time of the patient killings in Germany after 1939. Methodologically the study follows strategies of historical network analysis including the main actors of the foundation process. The foundation of this society can be seen as the result of the interaction of a) the Reichs-Health-Agency, its president Hans Reiter, and Fritz Rott as National Socialist health politicians, b) the scientific development geared to this policy of a young discipline that shared its knowledge base as well as its medical ‘object’ with established specialties like psychiatry and pediatrics, c) a postulated need for character studies, prognosis and selection, and d) personal as well as professional-political interests of the main protagonists Schroeder and Villinger. Once more it is obvious that medicine and politics were not only interwoven, but in certain areas in accordance with each other. Borders could rather be established between social regulatory “instances”. The foundation of the DGKH (Deutsche Gesellschaft für Kinderpsychiatrie und Heilpädagogik; German Society for Child Psychiatry and Therapeutic Education) is an example of a ‘radical regulatory reasoning’ according to Raphael, that by means of “institutional arrangements at medium level” (Raphael, 2001) was supposed to implement the ‘new National-Socialist order’.

  13. Principles and practical procedures for acute psychological first aid training for personnel without mental health experience.

    Science.gov (United States)

    Everly, George S; Flynn, Brian W

    2006-01-01

    Most authorities agree that mass disasters leave in their wake a need for some form of acute mental health services. However, a review of current literature on crisis intervention and disaster mental health reveals differing points of view on the methods that should be employed (Raphael, 1986; NIMH, 2002). Nevertheless, there appears to be virtual universal endorsement, by relevant authorities, of the value of acute "psychological first aid" (American Psychiatric Association, 1954; USDHHS, 2004; Raphael, 1986; NIMH, 2002; Institute of Medicine, 2003; WHO, 2003; DoD/VAPTSD, 2004; Ritchie, et al., 2004; Friedman, Hamblin, Foa, & Charney, 2004). Psychological first aid (PFA), as an acute mental health intervention, seems uniquely applicable to public health settings, the workplace, the military, mass disaster venues, and even the demands of more well circumscribed critical incidents, e.g., dealing with the psychological aftermath of accidents, robberies, suicide, homicide, or community violence. In this document, we shall introduce the notion of psychological first aid (PFA) as one aspect of a psychological continuum of care, offer a rudimentary definition of PFA, and provide the reader with a practicalframework for its implementation utilizing the individual psychological first aid (iPFA)format. The goal of this paper is to better prepare public health, public safety, and other disaster response personnel who do not possess formal clinical mental health degrees or specialized training to provide iPFA services to primary and secondary disaster victims.

  14. Surgery resident learning styles and academic achievement.

    Science.gov (United States)

    Contessa, Jack; Ciardiello, Kenneth A; Perlman, Stacie

    2005-01-01

    To determine if surgical residents share a preferred learning style as measured by Kolb's Learning Style Inventory (LSI) and if a relationship exists between resident learning style and achievement as measured by a standardized examination (AME). Also, core faculty learning styles were assessed to determine if faculty and residents share a preferred learning style. Kolb's LSI, Version 3, was administered to 16 surgical residents and the residency program's core faculty of 6 attending physicians. To measure academic achievement, the American Medical Education (AME) examination was administered to residents. The Hospital of Saint Raphael, General Surgery Residency Program, New Haven, Connecticut. Both instruments were administered to residents during protected core curriculum time. Core faculty were administered the LSI on an individual basis. Surgical residents of the Hospital of Saint Raphael's General Surgery Residency Program and 6 core faculty members Analysis of resident learning style preference revealed Converging as the most commonly occurring style for residents (7) followed by Accommodating (5), Assimilating (3), and Diverging (1). The predominant learning style for core faculty was also Converging (4) with 2 Divergers. The average score for the Convergers on the AME was 62.6 compared with 42 for the next most frequently occurring learning style, Accommodators. In this surgical residency program, a preferred learning style for residents seems to exist (Converging), which confirms what previous studies have found. Additionally, residents with this learning style attained a higher average achievement score as measured by the AME. Also, core faculty share the same preferential learning style as this subset of residents.

  15. Air contamination measurements for the evaluation of internal dose to workers in nuclear medicine departments

    Science.gov (United States)

    De Massimi, B.; Bianchini, D.; Sarnelli, A.; D'Errico, V.; Marcocci, F.; Mezzenga, E.; Mostacci, D.

    2017-11-01

    Radionuclides handled in nuclear medicine departments are often characterized by high volatility and short half-life. It is generally difficult to monitor directly the intake of these short-lived radionuclides in hospital staff: this makes measuring air contamination of utmost interest. The aim of the present work is to provide a method for the evaluation of internal doses to workers in nuclear medicine, by means of an air activity sampling detector, to ensure that the limits prescribed by the relevant legislation are respected. A continuous air sampling system measures isotope concentration with a Nal(TI) detector. Energy efficiency of the system was assessed with GEANT4 and with known activities of 18F. Air is sampled in a number of areas of the nuclear medicine department of the IRST-IRCCS hospital (Meldola- Italy). To evaluate committed doses to hospital staff involved (doctors, technicians, nurses) different exposure situations (rooms, times, radionuclides etc) were considered. After estimating the intake, the committed effective dose has been evaluated, for the different radionuclides, using the dose coefficients mandated by the Italian legislation. Error propagation for the estimated intake and personal dose has been evaluated, starting from measurement statistics.

  16. Study of albumin and fibrinogen membranes formed by interfacial crosslinking using microfluidic flow

    Energy Technology Data Exchange (ETDEWEB)

    Chang Hong; Khan, Rachel; Rong, Zimei; Vadgama, Pankaj [IRC in Biomedical Materials, Queen Mary University of London, Mile End Road, London E1 4NS (United Kingdom); Sapelkin, Andrei, E-mail: p.vadgama@qmul.ac.u [Department of Physics, Queen Mary University of London, Mile End Road, London E1 4NS (United Kingdom)

    2010-09-15

    Microfluidics enables scale reduction in sample volume with obvious benefits for reagent conservation. In contrast to conventional macro-scale flow, microfluidics also offers unprecedented control over flow dynamics. In particular, laminar flow is readily achieved, allowing for new analytical and synthetic strategies. Here, two parallel flows of buffer and xylene were used to create a stable liquid-liquid interface within linear micro-channels. These, respectively, carried protein (albumin or fibrinogen) and an acyl chloride to effect protein crosslinking. This created robust, micro-membranes at the interface that bisected the fluid channel. Membrane formation was self-limiting, with fibrinogen membranes showing greater solute permeability than albumin, based on dye transport (Ponceau S, Meldola Blue). The crosslinker isophthaloyl dichloride led to thinner, less permeable membranes than terephthaloyl chloride. Larger surface area membranes formed at a static liquid-liquid interface served as a more physically accessible model and allowed precise electrochemical determination of acetaminophen, catechol and peroxide diffusion coefficients, which confirmed the greater fibrinogen permeability. Scanning electron microscopy (SEM) of the membranes also indicated a higher population of discrete nanopores at the fibrinogen surface. A crosslinking pH had a strong effect on overall permeability. Adhesion of B50 neuronal cells was demonstrated, and it is proposed that the membranes could facilitate cell growth through bidirectional nutrient supply in a micrbioreactor format.

  17. Evaluation of newer risk markers for coronary heart disease risk classification: a cohort study.

    Science.gov (United States)

    Kavousi, Maryam; Elias-Smale, Suzette; Rutten, Joost H W; Leening, Maarten J G; Vliegenthart, Rozemarijn; Verwoert, Germaine C; Krestin, Gabriel P; Oudkerk, Matthijs; de Maat, Moniek P M; Leebeek, Frank W G; Mattace-Raso, Francesco U S; Lindemans, Jan; Hofman, Albert; Steyerberg, Ewout W; van der Lugt, Aad; van den Meiracker, Anton H; Witteman, Jacqueline C M

    2012-03-20

    Whether newer risk markers for coronary heart disease (CHD) improve CHD risk prediction remains unclear. To assess whether newer risk markers for CHD risk prediction and stratification improve Framingham risk score (FRS) predictions. Prospective population-based study. The Rotterdam Study, Rotterdam, the Netherlands. 5933 asymptomatic, community-dwelling participants (mean age, 69.1 years [SD, 8.5]). Traditional CHD risk factors used in the FRS (age, sex, systolic blood pressure, treatment of hypertension, total and high-density lipoprotein cholesterol levels, smoking, and diabetes) and newer CHD risk factors (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima-media thickness, peripheral arterial disease, and pulse wave velocity). Adding CAC scores to the FRS improved the accuracy of risk predictions (c-statistic increase, 0.05 [95% CI, 0.02 to 0.06]; net reclassification index, 19.3% overall [39.3% in those at intermediate risk, by FRS]). Levels of N-terminal fragment of prohormone B-type natriuretic peptide also improved risk predictions but to a lesser extent (c-statistic increase, 0.02 [CI, 0.01 to 0.04]; net reclassification index, 7.6% overall [33.0% in those at intermediate risk, by FRS]). Improvements in predictions with other newer markers were marginal. The findings may not be generalizable to younger or nonwhite populations. Among 12 CHD risk markers, improvements in FRS predictions were most statistically and clinically significant with the addition of CAC scores. Further investigation is needed to assess whether risk refinements using CAC scores lead to a meaningful change in clinical outcome. Whether to use CAC score screening as a more routine test for risk prediction requires full consideration of the financial and

  18. Metabolic syndrome and Framingham risk score in obese young adults

    Directory of Open Access Journals (Sweden)

    Felix F. Widjaja

    2013-05-01

    Full Text Available Background: The increase number of the metabolic syndrome (MetS among young adults was mostly caused by obesity. MetS increases the risk of coronary heart disease (CHD which can be estimated by Framingham risk score (FRS. The study was aimed to know the prevalence of MetS and FRS in obese young adults and to associate them with the components of MetS. Methods: A total of 70 male and female students aged 18 to 25 years with BMI ≥ 25 kg/m2 in Faculty of Medicine Universitas Indonesia were selected consecutively. The blood samples used to test fasting blood glucose, total cholesterol, high-density lipoprotein, and triglyceride were examined in Department of Clinical Pathology, Cipto Mangunkusumo Hospital after fasting for 14 to 16 hours. International Diabetes Federation (IDF definition was used to diagnose MetS. Univariate and bivariate analysis were done. Results: The prevalence of MetS based on IDF definition was 18.6% among obese young adults. The most associated MetS components was hypertriglyceridemia (OR 12.13; 95% CI 2.92-50.46; p = 0.001, followed with high blood pressure (OR 9.33; 95% CI 2.26-38.56; p = 0.001, low-HDL (OR 8.33; 95% CI 2.17-32.05; p = 0.003, and impaired fasting glucose (p = 0.03. Four subjects had FRS ≥ 1% and 66 subjects had risk < 1%. Increased FRS was not associated with MetS (p = 0.154. There was no component of MetS associated with increased FRS. Conclusion: Prevalence of MetS in obese young adults was similar with obese children and adolescents. Although no association of MetS and FRS was found, they are significant predictors for CHD which should not be used separately. (Med J Indones. 2013;22:100-6Keywords: Abdominal obesity, Framingham risk score, metabolic syndrome, young adults

  19. Flame retardant emission from e-waste recycling operation in northern Vietnam: Environmental occurrence of emerging organophosphorus esters used as alternatives for PBDEs

    Energy Technology Data Exchange (ETDEWEB)

    Matsukami, Hidenori, E-mail: matsukami.hidenori@nies.go.jp [Center for Material Cycles and Waste Management Research, National Institute for Environmental Studies (NIES), 16-2 Onogawa, Tsukuba 305-8506 (Japan); Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa 277-8563 (Japan); Tue, Nguyen Minh [Center for Marine Environmental Studies (CMES), Ehime University, 2-5 Bunkyo-cho, Matsuyama 790-8577 (Japan); Centre for Environmental Technology and Sustainable Development (CETASD), Hanoi University of Science, 334 Nguyen Trai, Hanoi (Viet Nam); Suzuki, Go [Center for Material Cycles and Waste Management Research, National Institute for Environmental Studies (NIES), 16-2 Onogawa, Tsukuba 305-8506 (Japan); Someya, Masayuki [Tokyo Metropolitan Research Institute for Environmental Protection, 1-7-5 Shinsuna Koto, Tokyo 136-0075 (Japan); Tuyen, Le Huu; Viet, Pham Hung [Centre for Environmental Technology and Sustainable Development (CETASD), Hanoi University of Science, 334 Nguyen Trai, Hanoi (Viet Nam); Takahashi, Shin [Center for Marine Environmental Studies (CMES), Ehime University, 2-5 Bunkyo-cho, Matsuyama 790-8577 (Japan); Center of Advanced Technology for the Environment, Faculty of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama 790-8566 (Japan); Tanabe, Shinsuke [Center for Marine Environmental Studies (CMES), Ehime University, 2-5 Bunkyo-cho, Matsuyama 790-8577 (Japan); Takigami, Hidetaka [Center for Material Cycles and Waste Management Research, National Institute for Environmental Studies (NIES), 16-2 Onogawa, Tsukuba 305-8506 (Japan); Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa 277-8563 (Japan)

    2015-05-01

    Three oligomeric organophosphorus flame retardants (o-PFRs), eight monomeric PFRs (m-PFRs), tetrabromobisphenol A (TBBPA), and polybrominated diphenyl ethers (PBDEs) were identified and quantified in surface soils and river sediments around the e-waste recycling area in Bui Dau, northern Vietnam. Around the e-waste recycling workshops, 1,3-phenylene bis(diphenyl phosphate) (PBDPP), bisphenol A bis(diphenyl phosphate) (BPA-BDPP), triphenyl phosphate (TPHP), TBBPA, and PBDEs were dominant among the investigated flame retardants (FRs). The respective concentrations of PBDPP, BPA-BDPP, TPHP, TBBPA and the total PBDEs were 6.6–14000 ng/g-dry, < 2–1500 ng/g-dry, 11–3300 ng/g-dry, < 5–2900 ng/g-dry, and 67–9200 ng/g-dry in surface soils, and 4.4–78 ng/g-dry, < 2–20 ng/g-dry, 7.3–38 ng/g-dry, 6.0–44 ng/g-dry and 100–350 ng/g-dry in river sediments. Near the open burning site of e-waste, tris(methylphenyl) phosphate (TMPP), (2-ethylhexyl)diphenyl phosphate (EHDPP), TPHP, and the total PBDEs were abundantly with respective concentrations of < 2–190 ng/g-dry, < 2–69 ng/g-dry, < 3–51 ng/g-dry and 1.7–67 ng/g-dry in surface soils. Open storage and burning of e-waste have been determined to be important factors contributing to the emissions of FRs. The environmental occurrence of emerging FRs, especially o-PFRs, indicates that the alternation of FRs addition in electronic products is shifting in response to domestic and international regulations of PBDEs. The emissions of alternatives from open storage and burning of e-waste might become greater than those of PBDEs in the following years. The presence and environmental effects of alternatives should be regarded as a risk factor along with e-waste recycling. - Highlights: • Open storage and burning of e-waste contributed to emission of FRs. • Types of FRs currently in emission are shifting in response to regulations of PBDEs. • Emerging PFRs were detected in soils and sediments around e

  20. Polybrominated diphenyl ethers and multiple stressors influence the reproduction of free-ranging tree swallows (Tachycineta bicolor) nesting at wastewater treatment plants.

    Science.gov (United States)

    Gilchrist, Tiffany T; Letcher, Robert J; Thomas, Philippe; Fernie, Kim J

    2014-02-15

    Reproductive success of birds is influenced by maternal factors, ambient temperatures, predation, food supply, and/or exposure to environmental contaminants e.g., flame retardants (FRs). Reproduction of tree swallows (Tachycineta bicolor) was compared among waste water treatment plants (WWTPs) and a reference reservoir in Ontario, Canada (2007-2010), to determine the importance of exposure to polybrominated diphenyl ether (PBDEs) FRs within a complex contaminant cocktail, relative to natural and biological factors known to influence avian reproduction. The birds primarily consumed insects emerging from the reference reservoir and WWTP outflows, where effluent mixed with receiving waters. FR egg concentrations were dominated by 5 PBDE congeners (∑5PBDEs): 2,2'.4,4',5-pentabromodiphenyl ether (BDE-99), 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), 2,2'4,4',6-pentabromodiphenyl ether (BDE-100), 2,2',4,4',5,5'-hexabromodiphenyl ether (BDE-153), and 2,2',4,4',5,6'-hexabromodiphenyl ether (BDE-154), with much lower concentrations of decabromodiphenylether (BDE-209), hexabromocyclododecane (HBCDD), and novel FRs. Although higher than ∑5PBDEs, polychlorinated biphenyls (PCBs) egg concentrations were unlikely to affect the swallows' reproduction. Clutch size and timing, fledging, breeding success, and predation, varied significantly among sites, generally being poorer at WWTP1 and better at WWTP2. The early reproductive stages were sensitive to some FRs at measured concentrations. The ∑5PBDEs, maternal age, and minimum ambient temperatures predicted onset of egg laying in the most parsimonious statistical model, and there were positive relationships between egg size and HBCDD or BDE-209 concentrations. However, there were no significant correlations with any reproductive measures, individual BDE congeners or low concentrations of novel FRs, in this first such report for novel FRs and wild birds. Tree swallows are passerines, and passerines may differ from birds of prey

  1. Response to intravenous allogeneic equine cord-blood-derived mesenchymal stromal cells administered from chilled or frozen state in serum and protein free media

    Directory of Open Access Journals (Sweden)

    Lynn Brandon Williams

    2016-07-01

    Full Text Available Equine Mesenchymal stromal cells (MSC are commonly transported, chilled or frozen, to veterinary clinics. These MSC must remain viable and minimally affected by culture, transport, or injection processes. The safety of two carrier solutions developed for optimal viability and excipient use were evaluated in ponies, with and without allogeneic cord blood-derived (CB MSC. We hypothesized that neither the carrier solutions nor CB-MSC would elicit measurable changes in clinical, hematological, or biochemical parameters. In 9 ponies (study 1 a bolus of HypoThermosol® FRS (HTS-FRS, CryoStor® CS10 (CS10 or saline was injected IV (n=3/treatment. Study 2, following a one week washout period 5x107 pooled allogeneic CB-MSC were administered IV in HTS-FRS following 24h simulated chilled transport. Study 3, following another one week washout period 5x107 pooled allogeneic CB-MSC were administered IV in CS10 immediately after thawing. Nine ponies received CB-MSCs in study 2 and 3 and three ponies received the cell carrier media without cells. CB-MSCs were pooled in equal numbers from five unrelated donors. In all studies ponies were monitored with physical examination, and blood collection for 7 days following injection. CD4 and CD8 lymphocyte populations were also evaluated in each blood sample.In all three studies, physical exam, complete blood cell count, serum biochemistry, and coagulation panel did not deviate from established normal ranges. Proportions of CD4+ and CD8+ lymphocytes increased at 168h post injection in CB-MSC treatment groups regardless of the carrier solution. Decreases in CD4+/CD8+ double positive populations were observed at 24 h and 72 h in CB-MSC treated animals. There was no difference in viability between CB-MSC suspended in HTS-FRS or CS10.HTS-FRS and CS10 used for low volume excipient injection of MSC suspensions was not associated with short-term adverse reactions. HTS-FRS and CS10 both adequately maintain CB-MSC viability

  2. Using the NSQIP Pancreatic Demonstration Project to Derive a Modified Fistula Risk Score for Preoperative Risk Stratification in Patients Undergoing Pancreaticoduodenectomy.

    Science.gov (United States)

    Kantor, Olga; Talamonti, Mark S; Pitt, Henry A; Vollmer, Charles M; Riall, Taylor S; Hall, Bruce L; Wang, Chi-Hsiung; Baker, Marshall S

    2017-05-01

    The Fistula Risk Score (FRS) is a clinical tool developed from single-institutional data using primarily intraoperative factors to characterize the risk of clinically relevant pancreatic fistula (CR-POPF) after pancreaticoduodenectomy. We developed a modified FRS based on objective, nationally accrued data that is more readily determined before resection. The 2012 NSQIP Pancreatic Demonstration Project (PDP) was used to identify 1,731 pancreaticoduodenectomy resections over 14 months (2011 to 2012). A randomly generated 70% cohort was used for model development, and the remaining 30% for internal validation. Univariate analysis was used to identify predictors of CR-POPF. Variables with a value of p performance data for individual surgeons to national norms, improved perioperative counseling, and potential for scrutinizing and/or implementing interventions designed to decrease CR-POPF rates. Copyright © 2017 American College of Surgeons. Published by Elsevier Inc. All rights reserved.

  3. Holographic Grating Studies of ''Anomalous" Mass Diffusion in a Cyanobiphenyl Liquid Crystal

    Science.gov (United States)

    Campbell, Wesley C.; Thompson, Alexis L.; Spiegel, Daniel R.

    2000-03-01

    Experimental investigations of mass diffusion in liquid crystals (LCs) have proved rather problematic, with significant disagreements reported in the literature. Recent improvements in the understanding of holographic relaxation methods prompted us to study the diffusion of methyl red in 5CB using forced Rayleigh scattering (FRS). Previous investigations reported a surprising discontinuity in the diffusion dynamics at the nematic-isotropic transition temperature T(NI), along with unexpected maxima in the nematic diffusion coefficients just below T(NI). Working at high sensitivities, we find that the FRS signal is highly non-exponential in the isotropic phase, which affects significantly the values of the isotropic diffusion coefficients inferred from the data. In fact, the previously reported discontinuity at T(NI) does not appear in the new data; however, our work confirms the existence of the maxima below T(NI).

  4. Global Consumption of Flame Retardants and Related Environmental Concerns: A Study on Possible Mechanical Recycling of Flame Retardant Textiles

    Directory of Open Access Journals (Sweden)

    Sohail Yasin

    2016-05-01

    Full Text Available Flame retardants (FRs have been around us for decades to increase the chances of survival against fire or flame by limiting its propagation. The FR textiles, irrespective of their atmospheric presence are used in baby clothing, pushchairs, car seats, etc. The overall FR market in Asia, Europe, and the United States in 2007 was around 1.8 million metric tonnes. It is estimated that the worldwide consumption of FRs will reach 2.8 million tonnes in 2018. Unfortunately, a sustainable approach for textile waste, especially in the case of FR textiles, is absent. Incineration and landfill of FR textiles are hindered by various toxic outcomes. To address the need for sustainable methods of discarding FR textiles, the mechanical recycling of cotton curtains was evaluated.

  5. Environmental Impact of Flame Retardants (Persistence and Biodegradability

    Directory of Open Access Journals (Sweden)

    Asher Brenner

    2009-02-01

    Full Text Available Flame-retardants (FR are a group of anthropogenic environmental contaminants used at relatively high concentrations in many applications. Currently, the largest market group of FRs is the brominated flame retardants (BFRs. Many of the BFRs are considered toxic, persistent and bioaccumulative. Bioremediation of contaminated water, soil and sediments is a possible solution for the problem. However, the main problem with this approach is the lack of knowledge concerning appropriate microorganisms, biochemical pathways and operational conditions facilitating degradation of these chemicals at an acceptable rate. This paper reviews and discusses current knowledge and recent developments related to the environmental fate and impact of FRs in natural systems and in engineered treatment processes.

  6. Half-life measurements for neutral and highly-charged {alpha}-emitters

    Energy Technology Data Exchange (ETDEWEB)

    Farinon, Fabio [GSI, Darmstadt (Germany); Justus-Liebig Universitaet, Giessen (Germany); Collaboration: E073-Collaboration

    2012-07-01

    The influence of the bound electron cloud on the {alpha}-decay constant {lambda} has been discussed theoretically since the late 50s. Tiny changes in Q-values and {alpha}-decay half-lives of fully stripped ions are expected and can provide information on the electron screening energy, thereby deducing reliable reaction rates in stellar environments. Recently, the measurements of {alpha}-decay half-lives are feasible also for highly-charged radioactive nuclides. Using a {sup 238}U beam at relativistic energies at the present FRS-ESR facility at GSI it is possible to produce, efficiently separate and store highly charged {alpha}-emitters. {sup 213}Fr{sup 86+} have been investigated by using the Schottky Mass Spectrometry technique. In order to establish a solid reference data set, lifetime measurements of the corresponding neutral atoms have been performed directly at the FRS by implanting the separated ions into an active silicon stopper. These results are reported.

  7. Simulations of a dual TOF detector system for isochronous mass spectrometry in the collector ring at FAIR

    Energy Technology Data Exchange (ETDEWEB)

    Diwisch, Marcel; Kuzminchuk-Feuerstein, Natalia [Justus-Liebig-Universitaet Giessen (Germany); Dickel, Timo; Geissel, Hans; Knoebel, Ronja; Plass, Wolfgang; Scheidenberger, Christoph [Justus-Liebig-Universitaet Giessen (Germany); GSI, Darmstadt (Germany); Weick, Helmut [GSI, Darmstadt (Germany)

    2013-07-01

    Direct mass measurements of short-lived exotic nuclei yield key information for modern nuclear physics. Experimentally determined mass values of exotic nuclei have a big impact on numerous applications in fundamental and applied science. With the Superconducting-Fragment Separator (Super-FRS) at the new FAIR facility a whole new range of exotic nuclei far away from stability will be accessible. Higher beam intensities and larger phase space volumes impose new challenges for the detection systems. To measure masses of short-lived exotic nuclei one can use the Isochronous Mass Spectrometry (IMS) which presently is successfully performed at the FRS-ESR facility. For IMS in the future Collector Ring, (CR) a first version of a new dual Time-Of-Flight (TOF) detector system, which fulfills the requirements of the new beam parameters has been designed. Simulation results for the new TOF detector in the CR will be shown.

  8. Missing Mass Spectroscopy of η′ Mesic Nuclei with the (p,d Reaction at GSI

    Directory of Open Access Journals (Sweden)

    Tanaka Yoshiki K.

    2014-03-01

    Full Text Available We plan a missing-mass spectroscopy experiment of η′ mesic nuclei with the 12C(p,dη′⊗11C reaction to study in-medium properties of the η′ meson. In nuclear medium, due to restoration of chiral symmetry, the mass of the η′ meson may be reduced, and η′ bound states in a nucleus may exist. The experiment will be started at GSI with a 2.5 GeV proton beam using FRS as a spectrometer and will be continued at Super-FRS at FAIR. The plan of the experiment and development of a Cherenkov detector and an optics mode are described.

  9. Systematic Review of Self-Report Family Assessment Measures.

    Science.gov (United States)

    Hamilton, Elena; Carr, Alan

    2016-03-01

    A systematic review of self-report family assessment measures was conducted with reference to their psychometric properties, clinical utility and theoretical underpinnings. Eight instruments were reviewed: The McMaster Family Assessment Device (FAD); Circumplex Model Family Adaptability and Cohesion Evaluation Scales (FACES); Beavers Systems Model Self-Report Family Inventory (SFI); Family Assessment Measure III (FAM III); Family Environment Scale (FES); Family Relations Scale (FRS); and Systemic Therapy Inventory of Change (STIC); and the Systemic Clinical Outcome Routine Evaluation (SCORE). Results indicated that five family assessment measures are suitable for clinical use (FAD, FACES-IV, SFI, FAM III, SCORE), two are not (FES, FRS), and one is a new system currently under-going validation (STIC). © 2015 Family Process Institute.

  10. Towards multi-hit readout of TPCs for exotic beam tracking

    Energy Technology Data Exchange (ETDEWEB)

    Allred, Timothy; Enders, Joachim; Hucka, Jan-Paul; Schlemme, Steffen [Institut fuer Kernphysik, TU Darmstadt (Germany); Nociforo, Chiara; Pietri, Stephane; Prochazka, Andrej [GSI Helmholtzzentrum fuer Schwerionenforschung (Germany)

    2015-07-01

    The Super-FRS beam diagnostics system supports the set up and adjustment of the separator and provides tracking and event-by-event particle identification. A TPC-type detector with GEM amplification and with multi-hit single-strip readout is proposed to be used as a tracking detector. The main challenges for such a detector are position resolution below 1 mm, high dynamic range (1000) and high-efficiency tracking up to 10 MHz ion rate. One of the planned improvements towards a high-rate capability of single-ion tracking is the multi-hit readout of the TPC detectors. Present TPC detectors with delay-line readout were tested with multihit electronics at the GSI fragment separator FRS with Au beam at 1 GeV/nucl. up to 150 kHz. Results are presented in comparison to single-hit readout.

  11. Data-flow coupling and data-acquisition triggers for the PreSPEC-AGATA campaign at GSI

    Science.gov (United States)

    Ralet, D.; Pietri, S.; Aubert, Y.; Bellato, M.; Bortolato, D.; Brambilla, S.; Camera, F.; Dosme, N.; Gadea, A.; Gerl, J.; Golubev, P.; Grave, X.; Johansson, H. T.; Karkour, N.; Korichi, A.; Kurz, N.; Lafay, X.; Legay, E.; Linget, D.; Pietralla, N.; Rudolph, D.; Schaffner, H.; Stezowski, O.; Travers, B.; Wieland, O.

    2015-06-01

    The PreSPEC setup for high-resolution γ-ray spectroscopy using radioactive ion beams was employed for experimental campaigns in 2012 and 2014. The setup consisted of the state of the art Advanced GAmma Tracking Array (AGATA) and the High Energy γ deteCTOR (HECTOR+) positioned around a secondary target at the final focal plane of the GSI FRagment Separator (FRS) to perform in-beam γ-ray spectroscopy of exotic nuclei. The Lund York Cologne CAlorimeter (LYCCA) was used to identify the reaction products. In this paper we report on the trigger scheme used during the campaigns. The data-flow coupling between the Multi-Branch System (MBS) based Data AcQuisition (DAQ) used for FRS-LYCCA and the "Nouvelle Acquisition temps Réel Version 1.2 Avec Linux" (NARVAL) based acquisition system used for AGATA are also described.

  12. Development of slowed down beams at GSI

    Energy Technology Data Exchange (ETDEWEB)

    Boutachkov, Plamen; Farinon, Fabio; Gorska, Magdalena; Gerl, Juergen; Kojouharov, Ivan; Naqvi, Farheen; Nociforo, Chiara; Prokopowicz, Wawrzyniec; Pietri, Stephane; Prochazka, Andrej; Schaffner, Henning; Weick, Helmut [GSI, Darmstadt (Germany); Hadynska, Katarzyna; Napiorkowski, Pawel; Pietak, Daniel [Warsaw University, Warsaw (Poland); Janik, Rudo; Strmen, Peter [Komenskeho University, Bratislava (Slovakia); Kondratyev, Nikolai A. [FLNR, JINR, Dubna (Russian Federation); Alvarez, Marcos A.G. [CNA, Seville (Spain); Mukha, Ivan [Seville University, Seville (Spain)

    2009-07-01

    The NUSTAR/HISPEC slowed down beam project at GSI/FAIR is dedicated to rare isotopes with energies of upto 10 MeV/u. These radioactive beams will be used for spectroscopy and reactions studies. The setup for slowing down will utilize a thick degrader positioned after the FRS/Super-FRS separators at GSI/FAIR, followed by transmission detectors for energy and trajectory reconstruction. As a test, Coulomb excitation of a slowed down {sup 64}Ni beam on a gold target was performed in Sep-Oct 2008 at GSI. TPC and MCP detectors were used for the tracking of the beam before and after slowing it down. The gold target, placed after the tracking setup, was surrounded partially with two DSSSDs and NaI {gamma}-detectors. The results from the test experiment and a comparison to simulations are presented.

  13. Plasmonic Fano resonances in novel nanostructure consisting of two rings with different diameter

    Science.gov (United States)

    Liu, Tongtong; Shi, Yusen; Xia, Feng; Yun, Maojin

    2017-08-01

    In this paper, a novel metallic nanostructure consisting of two rings with different diameter is proposed to generate intense plasmonic Fano Resonances (FRs). In this nanostructure, the FRs is explained by the interference between spectrally overlapping narrow subradiant (dark) and broad superradiant (bright) plasmonic modes and is simulated by COMSOL Multiphysics based on Finite Element Method. The simulation shows that dipolar resonance only occurs in the small-diameter ring as a bright plasmon mode, other than the large-diameter ring. It can be found that the Fano resonance can be generated in a metallic nanostructure consisting of two rings with different diameter. Such structure will have many potential applications in the field of chemical and biological sensors in the future.

  14. Performance profiles of major energy producers 1992

    Energy Technology Data Exchange (ETDEWEB)

    1994-01-13

    Performance Profiles of Major Energy Producers 1992 is the sixteenth annual report of the Energy Information Administration`s (EIA) Financial Reporting System (FRS). The report examines financial and operating developments, with particular reference to the 25 major energy companies (the FRS companies) required to report annually on Form EIA-28. Financial information is reported by major lines of business, including oil and gas production, petroleum refining and marketing, and other energy operations. Domestic and international operations are examined separately in this report. The data are presented in the context of key energy market developments with a view toward identifying changing strategies of corporate development and measuring the apparent success of current ongoing operations.

  15. Data-flow coupling and data-acquisition triggers for the PreSPEC-AGATA campaign at GSI

    Energy Technology Data Exchange (ETDEWEB)

    Ralet, D., E-mail: D.Ralet@gsi.de [Institut für Kernphysik, Technische Universität Darmstadt, Darmstadt (Germany); GSI, Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt (Germany); Pietri, S. [GSI, Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt (Germany); Aubert, Y. [Institut de Physique Nucléaire, Orsay (France); Bellato, M.; Bortolato, D. [Istituto Nazionale di Fisica Nucleare sezione di Padova, Padova (Italy); Brambilla, S.; Camera, F. [Istituto Nazionale di Fisica Nucleare sezione di Milano, Milano (Italy); Dosme, N. [CSNSM, Université Paris-Sud, Orsay (France); Gadea, A. [Instituto di Fisica Corpuscular, Valencia (Spain); Gerl, J. [GSI, Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt (Germany); Golubev, P. [Department of Physics, Lund University, Lund (Sweden); Grave, X. [CSNSM, Université Paris-Sud, Orsay (France); Johansson, H.T. [Chalmers University of Technology, Göteborg (Sweden); Karkour, N.; Korichi, A. [CSNSM, Université Paris-Sud, Orsay (France); Kurz, N. [GSI, Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt (Germany); Lafay, X.; Legay, E.; Linget, D. [CSNSM, Université Paris-Sud, Orsay (France); Pietralla, N. [Institut für Kernphysik, Technische Universität Darmstadt, Darmstadt (Germany); GSI, Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt (Germany); and others

    2015-06-21

    The PreSPEC setup for high-resolution γ-ray spectroscopy using radioactive ion beams was employed for experimental campaigns in 2012 and 2014. The setup consisted of the state of the art Advanced GAmma Tracking Array (AGATA) and the High Energy γ deteCTOR (HECTOR+) positioned around a secondary target at the final focal plane of the GSI FRagment Separator (FRS) to perform in-beam γ-ray spectroscopy of exotic nuclei. The Lund York Cologne CAlorimeter (LYCCA) was used to identify the reaction products. In this paper we report on the trigger scheme used during the campaigns. The data-flow coupling between the Multi-Branch System (MBS) based Data AcQuisition (DAQ) used for FRS-LYCCA and the “Nouvelle Acquisition temps Réel Version 1.2 Avec Linux” (NARVAL) based acquisition system used for AGATA are also described.

  16. Binary Mass Diffusion Constants in Nematic Liquid Crystals Studied by Forced Rayleigh Scattering

    Science.gov (United States)

    Hara, Masahiko; Ichikawa, Seiji; Takezoe, Hideo; Fukuda, Atsuo

    1984-11-01

    The binary mass diffusion constants of methyl red in the nematogens MBBA and 5CB were measured by forced Rayleigh scattering (FRS). The diffusion constants in the direction parallel to the director orientation, D//, are always larger than those perpendicular to it, D\\bot; D///D\\bot=1.6 for both MBBA and 5CB at room temperature. The temperature dependence is of the Arrhenius type except near the phase transition temperature of 5CB, where the values tend to deviate downwards. A comparison between the results obtained by other methods and those obtained by the present method suggests that the binary mass diffusion constant of methyl red obtained by FRS is a good measure of the self-diffusion constant.

  17. Clinical impact of metabolic syndrome by modified NCEP-ATPIII criteria on carotid atherosclerosis in Japanese adults.

    Science.gov (United States)

    Teramura, Megumi; Emoto, Masanori; Araki, Takahiro; Yokoyama, Hisayo; Motoyama, Koka; Shinohara, Kayo; Mori, Katsuhito; Koyama, Hidenori; Shoji, Tetsuo; Inaba, Masaaki; Nishizawa, Yoshiki

    2007-08-01

    The present study aimed to clarify the clinical impact of modified NCEP-ATP III criteria for metabolic syndrome (MS) and Framingham Risk Score (FRS) on carotid atherosclerosis in 615 Japanese adults (319 men and 296 women) including 307 with type 2 diabetes. Waist circumference was the only component from the original NCEP-ATP III criteria based on Japanese criteria. The intima-medial thickness (IMT) and stiffness parameter beta of the carotid artery were measured by ultrasound. Both IMT and stiffness parameter beta were significantly increased with the number of coexisting components of MS, and higher in subjects with MS than in those without MS (all Ps /= 20%. The modified NCEP-ATP III criteria for MS revealed an additive predictive impact on carotid atherosclerosis but no superiority to FRS.

  18. Determinants of profitability differences among major refiner/marketers

    Energy Technology Data Exchange (ETDEWEB)

    1985-01-01

    This report attempts to shed light on the factors affecting the differing profitabilities among companies, particularly, the effect of refinery upgrading, to contribute toward a better understanding of the performance of the domestic petroleum refining industry. The determinants of domestic refining-marketing profitability in the short run are evaluated. The focus is on those factors affecting the profitability of operations using the existing capital stock. Of particular interest is the effect on profitability of investments made for refinery upgrading. The refining-marketing segment is assumed to be operated to maximize profits of that segment rather than the profits of some other segment. The cost and financial data used in the analysis are proprietary line-of-business data from the FRS. The FRS provides detailed information on refining-marketing revenue, cost, income, and investment. The specific data used are discussed and key definitions provided later in this report. 14 refs., 1 fig., 2 tabs.

  19. Family eating habits, family support and subjective well-being in university students in Chile

    DEFF Research Database (Denmark)

    Schnettler, Berta; Höger, Yesly; Orellana, Ligia

    2016-01-01

    Aim: To characterize typologies of university students according to the perception of their families’ eating habits. Material and method: A questionnaire was applied to a non-probabilistic sample of 372 students of both genders at the Universidad de La Frontera, Temuco, Chile. The instrument...... included: the Family Eating Habits Questionnaire (FEHQ), the Satisfaction with Life Scale (SWLS), the Satisfaction with Food-related Life Scale (SWFL) and the Family Resources Scale (FRS). Estimated weight and height were asked about as well as sociodemographic variables. Results: Using an exploratory...... factor analysis (EFA) three factors were detected in the FEHQ: importance of eating to family members, cohesiveness of family eating, and pressure to eat. The EFA detected two factors on the FRS: intangible and tangible support. A confirmatory factor analysis (CFA) validated the structure of the FEHQ...

  20. Sensitive and selective detection of OH radicals using Faraday rotation spectroscopy at 2.8 µm.

    Science.gov (United States)

    Zhao, Weixiong; Wysocki, Gerard; Chen, Weidong; Fertein, Eric; Le Coq, David; Petitprez, Denis; Zhang, Weijun

    2011-01-31

    We report on the development of a Faraday rotation spectroscopy (FRS) instrument using a DFB diode laser operating at 2.8 µm for the hydroxyl (OH) free radical detection. The highest absorption line intensity and the largest gJ value make the Q (1.5) double lines of the 2Π3/2 state (υ = 1 ← 0) at 2.8 µm clearly the best choice for sensitive detection in the infrared region by FRS. The prototype instrument shows shot-noise dominated performance and, with an active optical pathlength of only 25 cm and a lock-in time constant of 100 ms, achieves a 1σ detection limit of 8.2 × 10(8) OH radicals/cm3.

  1. Interictal high frequency oscillations correlating with seizure outcome in patients with widespread epileptic networks in tuberous sclerosis complex.

    Science.gov (United States)

    Okanishi, Tohru; Akiyama, Tomoyuki; Tanaka, Shin-Ichi; Mayo, Ellen; Mitsutake, Ayu; Boelman, Cyrus; Go, Cristina; Snead, O Carter; Drake, James; Rutka, James; Ochi, Ayako; Otsubo, Hiroshi

    2014-10-01

    Multiple tubers in patients with tuberous sclerosis complex (TSC) often are responsible for drug-resistant epilepsy. The complexity of the epileptic network formed by multiple tubers complicates localization of the epileptogenic zone that is needed to design a surgical treatment strategy. High frequency oscillations (HFOs) on intracranial video-electroencephalography (IVEEG) may be a valuable surrogate marker for the localization of the epileptogenic zone. The purpose of this study was to test the hypothesis that high occurrence rate (OR) of interictal HFOs can guide the localization of the epileptogenic zone. We analyzed the OR of interictal HFOs at 80-200 Hz (ripples) and >200 Hz (fast ripples, FRs). We divided OR of interictal HFOs between high and low rates by thresholding. We analyzed the correlation between seizure outcomes using Engel classification and the resection ratio of the seizure onset zone (SOZ), and high-OR HFOs using ordinal logistic regression analysis. We collected 10 patients. The seizure outcomes resulted in Engel classification I in three patients, II in four, III in one, and IV in two. High-OR ripples (5-57 [mean 29] channels, 1-4 [2.8] lobes) and high-OR FRs (9-66 [mean 27] channels, 1-4 [2.6] lobes) were widely distributed. The resection ratio of SOZ did not show statistically significant correlation with the seizure outcome. The resection ratio of high-OR ripples showed statistically significant correlation with the seizure outcome (p = 0.038). The resection ratio of high-OR FRs showed statistically significant correlation with the seizure outcome (p = 0.048). The multiple extensive zones with high-OR HFOs suggest a complex and widespread epileptic network in patients with TSC. In a subset of TSC patients with drug-resistant epilepsy, resection of cortex with both interictal high-OR FRs and ripples on IVEEG correlated with a good seizure outcome. Wiley Periodicals, Inc. © 2014 International League Against Epilepsy.

  2. BODY IMAGE, ANXIETY AND DEPRESSION IN WOMEN SUBMITTED TO BARIATRIC SURGERY

    OpenAIRE

    Almeida,Sebastião de Sousa

    2015-01-01

    The impact of overweight and bariatric surgery can lead to psychological complications, such as: anxiety and depression and Body Image disorders. This study evaluated symptoms of anxiety and depression and body image in women submitted to bariatric surgery. Fifty women responded to Beck anxiety inventory (BAI), Beck depression inventory (BDI) and the figure rating scale (FRS) before and four months after bariatric surgery. Anthropometric evaluation was performed to obtain the Body Mass Index ...

  3. Development of an analytical method to quantify PBDEs, OH-BDEs, HBCDs, 2,4,6-TBP, EH-TBB, and BEH-TEBP in human serum.

    Science.gov (United States)

    Butt, Craig M; Miranda, Marie Lynn; Stapleton, Heather M

    2016-04-01

    Polybrominated diphenyl ethers (PBDEs) flame retardants (FRs) were phased-out in the mid-2000s (penta- and octaBDE) and 2013 (decaBDE); however, their hydroxylated metabolites (OH-BDEs) are still commonly detected in human serum. Today, novel FRs such as Firemaster® 550, a mixture that contains two brominated compounds, EH-TBB and BEH-TEBP are used as replacements for PBDEs in some applications, and there is a need to develop a comprehensive analytical method to assess exposure to both legacy PBDEs and novel FRs. This study developed a solid-phase extraction (SPE)-based method to analyze PBDEs, OH-BDEs, 2,4,6-tribromophenol (TBP), hexabromocylcododecane isomers (HBCDs), EH-TBB, and BEH-TEBP in human serum. Briefly, serum proteins were first denatured with formic acid, and then the target analytes were isolated using a SPE column. Finally, the extract was cleaned and fractioned using a silica SPE column. Method performance was assessed by spiking fetal bovine serum with 1-2 ng of the target analytes, and method accuracy was quantified by comparison to a serum Standard Reference Material (SRM). The developed method showed good recovery and accuracy for all target analytes with the exception of the very low and very high molecular weight PBDE congeners. Using this method, 43 serum samples collected from the Healthy Pregnancy, Healthy Baby Study (HPHB) cohort in Durham, NC, USA were analyzed for FRs. A novel finding was the ubiquitous detection of 2,4,6-TBP, at levels greater than the individual PBDE congeners. Furthermore, 2,4,6-TBP was positively correlated with PBDEs, suggesting that they may have a similar source of exposure, or that 2,4,6-TBP may result from metabolism of PBDEs in vivo.

  4. Chlorinated organophosphate and “legacy” brominated flame retardants in UK waste soft furnishings: A preliminary study

    Directory of Open Access Journals (Sweden)

    William A. Stubbings

    2016-12-01

    Full Text Available The Furniture and Furnishings (Fire Safety Regulations 1988 is the major driver for the use of chemical flame retardants (FRs in soft furnishings marketed in the UK. While these regulations specify the level of flame retardancy required, they do not specify how such levels should be achieved. Consequently, it remains unclear which FRs are present in UK soft furnishings. This is important not only to help assess what FRs we may be exposed to currently, but which FRs are currently entering the waste stream with concomitant potential for release into the environment. To address this data gap, concentrations of polybrominated diphenyl ethers (PBDEs, hexabromocyclododecane (HBCDD and a range of chlorinated organophosphate flame retardants (OPFRs were measured in samples of domestic and office waste soft furnishings products entering the UK waste stream in 2011 and 2012. This preliminary study measured the FR content of: carpets (n = 4, curtains (n = 7, mattress fabrics (n = 2, furniture foam (n = 9, and furniture upholstery textiles (n = 10. Polybrominated diphenyl ethers (PBDEs and hexabromocyclododecane (HBCDD were not found at significant concentrations (below detection limits in most samples in any of the twenty two analysed products. In contrast, 7 of the 9 furniture foam samples were treated with tris(2-chloroisopropylphosphate (TCIPP at a mean concentration of 1.9% w/w, with another single foam sample containing tris(1,3-dichloroisopropylphosphate (TDCIPP and tris(2-chloroethylphosphate (TCEP at 1.1 and 0.5% respectively. By comparison, PBDE concentrations are within the range reported previously for UK indoor dust [18], rather than the percent by weight levels required to impart flame retardancy.

  5. Exposure to flame retardants in electronics recycling sites.

    Science.gov (United States)

    Rosenberg, Christina; Hämeilä, Mervi; Tornaeus, Jarkko; Säkkinen, Kirsi; Puttonen, Katriina; Korpi, Anne; Kiilunen, Mirja; Linnainmaa, Markku; Hesso, Antti

    2011-07-01

    Waste electrical and electronic equipment (WEEE) contains various hazardous substances such as flame retardants (FRs). Inhalation exposures to many FRs simultaneously among WEEE recycling site workers have been little studied previously. The breathing zone airborne concentrations of five brominated FR compounds tetrabromobisphenol-A (TBBP-A), decabromodiphenylethane (DBDPE), hexabromocyclododecane, 1,2-bis(2,4,6-tribromophenoxy)ethane, hexabromobenzene, and one chlorinated FR (Dechlorane Plus®) were measured at four electronics recycling sites in two consecutive years. In addition, concentrations of polybrominated diphenyl ethers (PBDEs) and polybrominated biphenyls were measured. The three most abundant FRs in personal air samples were PBDEs (comprising mostly of deca-BDE), TBBP-A, and DBDPE, with mean concentrations ranging from 21 to 2320 ng m(-)(3), from 8.7 to 430 ng m(-3), and from 3.5 to 360 ng m(-3), respectively. At two of the sites, the emission control actions (such as improvements in ventilation and its maintenance and changes in cleaning habits) proved successful, the mean levels of FRs in personal samples being 10-68 and 14-79% of those from the previous year or alternatively below the limit of quantification. At the two remaining sites, the reductions in FR exposures were less consistent. The concentrations reported may pose a health hazard to the workers, although evaluation of the association between FR exposure and adverse health effects is hampered by lacking occupational exposure limits. Therefore, the exposures should be minimized by adequate control measures and maintaining good occupational hygiene practice.

  6. Dana-Farber Cancer Institute: Discovery of Novel Oncogenes | Office of Cancer Genomics

    Science.gov (United States)

    Widespread recurrent copy number alterations are observed across the majority of human cancers, yet the specific targets of such amplified or deleted regions remain undefined. Here, the CTD2 Center at the Dana Farber Cancer Institute took a systematic approach using cDNA overexpression screening to identify and validate oncogenes residing in such amplified regions. In representative examples, these experiments have identified the adaptor proteins CRKL, GAB2, FRS2 and the TLOC and SKIL proteins as novel amplified oncogenes.

  7. John Tyndall and the Royal Medal that was never struck

    Science.gov (United States)

    Jackson, Roland

    2014-01-01

    Just once in its long history has a Royal Medal been awarded but not presented. John Tyndall FRS (1820–93) was the chosen recipient in 1853 for his early work on diamagnetism but declined to accept it. The story of why Tyndall felt compelled to turn down this considerable honour sheds light on the scientific politics and personal relationships of the time, on the importance given to the study of magnetism, and on Tyndall's own character and career. PMID:24921107

  8. Country specific comparison for profile of chlorinated, brominated and phosphate organic contaminants in indoor dust. Case study for Eastern Romania, 2010.

    Science.gov (United States)

    Dirtu, Alin C; Ali, Nadeem; Van den Eede, Nele; Neels, Hugo; Covaci, Adrian

    2012-11-15

    We have evaluated the levels and specific profiles of several organohalogenated contaminants, including organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), and flame retardants (FRs), such as polybrominated diphenyl ethers (PBDEs), hexabromocyclododecanes (HBCDs), novel brominated FRs (NBFRs), and organophosphate FRs (OPFRs), in 47 indoor dust samples collected in 2010 from urban locations from Iasi, Eastern Romania. The dominant contaminants found in the samples were OPFRs (median sum OPFRs 7890 ng/g). Surprisingly, OCPs were also measured at high levels (median 1300 ng/g). Except for BDE 209 (median 275 ng/g), PBDEs were present in dust samples at relatively low levels (median sum PBDEs 8 ng/g). PCBs were also measured at low levels (median sum PCBs 35 ng/g), while NBFRs were only occasionally detected, showing a low usage in goods present on the Romanian market. The results of the present study evidence the existence of a multitude of chemical formulations in indoor dust. FRs are usually associated to human exposure via ingestion of dust, but other chemicals, such as OCPs, are not commonly reported in such matrix. Although OCPs were found at comparable levels with OPFRs in Romanian dust, OCPs possess a higher risk to human health due to their considerably lower reference dose (RfD) values. Indeed, the OCP exposure calculated for various intake scenarios was only 2-fold lower than the corresponding RfD. Therefore, the inclusion of OCPs as target chemicals in the indoor environment becomes important for countries where elevated levels in other environmental compartments have been previously shown. Copyright © 2012 Elsevier Ltd. All rights reserved.

  9. King, Prof. Sir David Anthony

    Indian Academy of Sciences (India)

    Elected: 1998 Honorary. King, Prof. Sir David Anthony Sc.D., FRS. Date of birth: 12 August 1939. Address: Chief Scientific Adivser & Head, Office of Science and Innovation, London SW1H 0ET, U.K.. Contact: Office: (+44-020) 7215 3821. Fax: (+44-020) 7215 0314. Email: mpst.king@dti.gsi.gov.uk, dak10@cus.cam.ac.uk.

  10. 'Swinging the Lamp': The Watch Manager's Career, Role and Occupational Identity within the Modernising Agenda of the UK Fire and Rescue Service

    OpenAIRE

    O'Connor, Sarah Jane

    2017-01-01

    This research focuses on the career and work identity of watch managers in the Fire and Rescue Service (FRS). Their role is to manage firefighters who are infamously known in political circles to possess grass root cultures that remain resistant to forms of change and modernisation. Watch managers are not only tasked with leading emergency teams at incidents but they are also at the receiving end of a relentless stream of political pressure to achieve change. This research draws on qualitativ...

  11. Incremental prognostic value of coronary computed tomographic angiography high-risk plaque characteristics in newly symptomatic patients.

    Science.gov (United States)

    Fujimoto, Shinichiro; Kondo, Takeshi; Takamura, Kazuhisa; Baber, Usman; Shinozaki, Tomohiro; Nishizaki, Yuji; Kawaguchi, Yuko; Matsumori, Rie; Hiki, Makoto; Miyauchi, Katsumi; Daida, Hiroyuki; Hecht, Harvey; Stone, Gregg W; Narula, Jagat

    2016-06-01

    The incremental prognostic value of the plaque features in coronary computed tomographic angiography (CTA) has not been well assessed. This study was designed to determine whether CTA high-risk plaques have prognostic value incremental to the Framingham risk score (FRS) and the severity of luminal obstruction. A total of 628 newly symptomatic patients without known coronary artery disease underwent CTA. They were followed for a median of 677 days during which there were 26 cardiac events, including cardiac death, acute myocardial infarction, and hospitalization for unstable angina. Incremental prognostic value of adding plaque characteristics to the number of diseased vessels and the FRS was evaluated using 3 Cox models and net reclassification indexes. The discrimination index was significantly increased by adding the number of diseased vessels to the FRS (change in c-statistic from 65.8% to 78.6%, p=0.028) but not significantly by further adding plaque characteristics (change in c-statistic from 78.6% to 80.0%, p=0.812). However, improved model-fitting by adding plaque characteristics into the linear combination with risk score and the number of diseased vessels (p=0.007 from likelihood ratio test) and the lowest value of Akaike's information criteria of that model indicated that plaque characteristics improved both predictive accuracy and discrimination perspective. More subjects reclassified by plaque characteristics were moved to directions consistent with their subsequent cardiac event status than in an inconsistent direction. Evaluation of CTA plaque characteristics may provide incremental prognostic value to the number of diseased vessels and the FRS. Copyright © 2015 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

  12. Comparison of the Framingham Risk Score, SCORE and WHO/ISH cardiovascular risk prediction models in an Asian population.

    Science.gov (United States)

    Selvarajah, Sharmini; Kaur, Gurpreet; Haniff, Jamaiyah; Cheong, Kee Chee; Hiong, Tee Guat; van der Graaf, Yolanda; Bots, Michiel L

    2014-09-01

    Cardiovascular risk-prediction models are used in clinical practice to identify and treat high-risk populations, and to communicate risk effectively. We assessed the validity and utility of four cardiovascular risk-prediction models in an Asian population of a middle-income country. Data from a national population-based survey of 14,863 participants aged 40 to 65 years, with a follow-up duration of 73,277 person-years was used. The Framingham Risk Score (FRS), SCORE (Systematic COronary Risk Evaluation)-high and -low cardiovascular-risk regions and the World Health Organization/International Society of Hypertension (WHO/ISH) models were assessed. The outcome of interest was 5-year cardiovascular mortality. Discrimination was assessed for all models and calibration for the SCORE models. Cardiovascular risk factors were highly prevalent; smoking 20%, obesity 32%, hypertension 55%, diabetes mellitus 18% and hypercholesterolemia 34%. The FRS and SCORE models showed good agreement in risk stratification. The FRS, SCORE-high and -low models showed good discrimination for cardiovascular mortality, areas under the ROC curve (AUC) were 0.768, 0.774 and 0.775 respectively. The WHO/ISH model showed poor discrimination, AUC=0.613. Calibration of the SCORE-high model was graphically and statistically acceptable for men (χ(2) goodness-of-fit, p=0.097). The SCORE-low model was statistically acceptable for men (χ(2) goodness-of-fit, p=0.067). Both SCORE-models underestimated risk in women (p<0.001). The FRS and SCORE-high models, but not the WHO/ISH model can be used to identify high cardiovascular risk in the Malaysian population. The SCORE-high model predicts risk accurately in men but underestimated it in women. Copyright © 2014. Published by Elsevier Ireland Ltd.

  13. Arctic Ice Studies

    Science.gov (United States)

    1993-02-01

    Hz-50 SO al cycles of phyto- and zooplankton andy remteseduring MIZEX 83 by ship kHz . Floe bumping and shearing are hypoth- dynamics and to assess the...olctoed n M trche e.F9Fither fhpes of ’ci ore lacritialp In hct, pae prsn, thre frs~ut-s eor mothe inesti.ai First-.a rogh a-re trcondsmartted

  14. In upwelling regions in which anchovy Engraulis spp. and sardine ...

    African Journals Online (AJOL)

    spamer

    and longitude) blocks extending from 29° to 36°45′S and from 15° to 28°00′E. Currents above the thermo- cline (vertically-averaged 30 and 50 m currents) were averaged for each grid block. The model was based on ADCP data collected during cruises on. F.R.S. Africana between September and March,. 1989–1993.

  15. Exotic nuclear studies around and below A = 100

    Energy Technology Data Exchange (ETDEWEB)

    Nara Singh, B. S.; Wadsworth, R.; Brock, T. S. [Department of Physics, University of York, Heslington, York, YO10 5DD (United Kingdom); Boutachkov, P.; Grawe, H.; Go, M.; Pietri, S.; Domingo-Pardo, C.; Caceres, L.; Engert, T.; Farinon, F.; Gerl, J.; Goel, N.; Gottardo, A.; Kojouharov, I.; Kurz, N.; Merchant, E.; Nociforo, C.; Prochazka, A.; Schaffner, H. [GSI Helmholtzzentrumfuer Schwerionenforschung, D-64291 Darmstadt (Germany); and others

    2011-11-30

    A RISING experiment with an aim to study exotic Cd nuclei was carried out at GSI-FRS facility. Some preliminary results from this experiment are presented here. In particular, the {beta} decay of {sup 96}Cd to {sup 96}Ag revealed the existence of a high spin isomer predicted a few decades ago. In this context, the structures of both these nuclei are discussed. Shell model calculations using the Gross-Frenkel interaction are used to interpret the results.

  16. Measurements of α-decay half-lives at GSI

    Science.gov (United States)

    Nociforo, C.; Farinon, F.; Musumarra, A.; Bosch, F.; Boutin, D.; Del Zoppo, A.; Figuera, P.; Fisichella, M.; Geissel, H.; Knöbel, R.; Kojouharov, I.; Kozhuharov, C.; Kuboki, T.; Kurcewicz, J.; Litvinov, Yu A.; Mazzocco, M.; Motizuki, Y.; Nolden, F.; Ohstubo, T.; Ohkuma, Y.; Patyk, Z.; Pellegriti, M. G.; Pietri, S.; Podolyak, Z.; Prochazka, A.; Sanjari, M. S.; Scheidenberger, C.; Scuderi, V.; Sun, B.; Suzuki, T.; Torresi, D.; Weick, H.; Winfield, J. S.; Winckler, N.; Winkler, M.; Wollersheim, H. J.; Yamaguchi, T.

    2012-10-01

    One of the major problems in nuclear astrophysics concerns the estimation of electron screening effects on nuclear reaction rates. We have proposed investigating the electron screening effects of nuclear systems which decay via α-particles, using fragmented beams at relativistic energies produced at the present GSI FRS-ESR facility. By looking at the modification of the half-lives and Qα-value of highly charged emitters, we expect to estimate the electron screening energies.

  17. Analysis of the Response of AGATA Detectors at GSI

    Science.gov (United States)

    Lalović, N.; Perez-Vidal, R. M.; Louchart, C.; Michelagnoli, C.; Ralet, D.; Arici, T.; Bazzacco, D.; Clément, E.; Gadea, A.; Gerl, J.; Kojouharov, I.; Korichi, A.; Labiche, M.; Ljungvall, J.; Lopez-Martens, A.; Nyberg, J.; Pietralla, N.; Pietri, S.; Rudolph, D.; Stezowski, O.

    2015-05-01

    In 2012 and 2014 the γ-ray tracking spectrometer AGATA was operated at the SIS/FRS facility at GSI in Darmstadt, Germany. The performance of the array is discussed, outlining some important aspects of the offline data processing and analysis. Relying on the data obtained from measurements with standard γ-ray sources, a first estimate of the photopeak efficiency and peak-to-total (P/T) is presented.

  18. Bias correction of estimates of familial risk from population-based cohort studies.

    Science.gov (United States)

    Leu, Monica; Czene, Kamila; Reilly, Marie

    2010-02-01

    In addition to guiding molecular epidemiology investigations, estimates of the increased risk of disease in relatives of affected persons are also important for screening and counselling decisions. Since precise estimation of such familial risks (FRs) requires large sample sizes, many of the estimates in common use have been obtained from historical electronic records of disease in entire populations, where the relatives of affected and unaffected persons are compared. These estimates may be biased due to failure to identify relatives as affected if they are diagnosed before the start-up date of disease registration. This article presents a method for correcting the bias in FR estimates from such misclassification of family history, using a simple formula that depends on the prevalence and sensitivity of the observed family history. The sensitivity is estimated by using the R package poplab to create realistic populations of related individuals and then imposing the start-up effect of disease registration. For a range of FRs, the truncation of family history is demonstrated to result in non-differential misclassification, and sensitivity that has little or no dependence on the FR. The bias is most pronounced for high FRs and for registers with a short life span, and increases with the age of the study cohort. In all the situations studied, the bias-corrected estimates are in excellent agreement with the true values. In summary, our method can correct the inevitable bias in FRs induced by using electronic population data, and is a feasible alternative to the use of validation samples.

  19. Analysis of the Response of AGATA Detectors at GSI

    Directory of Open Access Journals (Sweden)

    Lalović N.

    2015-01-01

    Full Text Available In 2012 and 2014 the γ-ray tracking spectrometer AGATA was operated at the SIS/FRS facility at GSI in Darmstadt, Germany. The performance of the array is discussed, outlining some important aspects of the offline data processing and analysis. Relying on the data obtained from measurements with standard γ-ray sources, a first estimate of the photopeak efficiency and peak-to-total (P/T is presented.

  20. High-frequency oscillations: what is normal and what is not?

    Science.gov (United States)

    Engel, Jerome; Bragin, Anatol; Staba, Richard; Mody, Istvan

    2009-04-01

    High-frequency oscillations (HFOs) in the 80-200 Hz range can be recorded from normal hippocampus and parahippocampal structures of humans and animals. They are believed to reflect inhibitory field potentials, which facilitate information transfer by synchronizing neuronal activity over long distances. HFOs in the range of 250-600 Hz (fast ripples, FRs) are pathologic and are readily recorded from hippocampus and parahippocampal structures of patients with mesial temporal lobe epilepsy, as well as rodent models of this disorder. These oscillations, and similar HFOs recorded from neocortex of patients, appear to identify brain tissue capable of spontaneous ictogenesis and are believed to reflect the neuronal substrates of epileptogenesis and epileptogenicity. The distinction between normal and pathologic HFOs (pHFOs), however, cannot be made on the basis of frequency alone, as oscillations in the FR frequency range can be recorded from some areas of normal neocortex, whereas oscillations in the ripple frequency range are present in epileptic dentate gyrus where normal ripples never occur and, therefore, appear to be pathologic. The suggestion that FRs may be harmonics of normal ripples is unlikely, because of their spatially distinct generators, and evidence that FRs reflect synchronized firing of abnormally bursting neurons rather than inhibitory field potentials. These synchronous population spikes, however, can fire at ripple frequencies, and their harmonics appear to give rise to FRs. Investigations into the fundamental neuronal processes responsible for pHFOs could provide insights into basic mechanisms of epilepsy. The potential for pHFOs to act as biomarkers for epileptogenesis and epileptogenicity is also discussed.

  1. Analyticko - syntetické modelování edukačního procesu v předmětu "integrovaný záchranný systém"

    OpenAIRE

    MENDLOVÁ, Ludmila

    2008-01-01

    The main units of the Integrated Rescue System (IRS) include the Fire Rescue Service (FRS), the Police of the Czech Republic (PCR) and the Health Rescue Service (HRS). The educational system of these units is not unified and thus there exist certain problems, which result from this disintegration. One of many consequences is for example unfamiliarity with competences at solving crisis situations and at carrying out rescue and liquidating work. The aim of this thesis was to analyze the educati...

  2. Functional relationships between genes associated with differentiation potential of aged myogenic progenitors

    Directory of Open Access Journals (Sweden)

    Radhakrishnan Nagarajan

    2010-09-01

    Full Text Available Aging is accompanied by considerable heterogeneity with possible co-expression of differentiation pathways. The present study investigates the interplay between crucial myogenic, adipogenic and Wnt-related genes orchestrating aged myogenic progenitor differentiation (AMPD using clonal gene expression profiling in conjunction with Bayesian structure learning (BSL techniques. The expression of three myogenic regulatory factor genes (Myogenin, Myf-5, MyoD1, four genes involved in regulating adipogenic potential (C/EBPα, DDIT3, FoxC2, PPARγ, and two genes in the Wnt-signaling pathway (Lrp5, Wnt5a known to influence both differentiation programs were determined across thirty-four clones by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR. Three control genes were used for normalization of the clonal expression data (18S, GAPDH and B2M. Constraint-based BSL techniques, namely (a PC Algorithm, (b Grow-shrink algorithm (GS, and (c Incremental Association Markov Blanket (IAMB were used to model the functional relationships (FRs in the form of acyclic networks from the clonal expression profiles. A novel resampling approach that obviates the need for a user-defined confidence threshold is proposed to identify statistically significant FRs at small sample sizes. Interestingly, the resulting acyclic network consisted of FRs corresponding to myogenic, adipogenic, Wnt-related genes and their interaction. A significant number of these FRs were robust to normalization across the three house-keeping genes and the choice of the BSL technique. The results presented elucidate the delicate balance between differentiation pathways (i.e. myogenic as well as adipogenic and possible cross-talk between pathways in AMPD.

  3. Study toward resolving the controversy over the definition of allergic fungal rhinosinusitis.

    Science.gov (United States)

    Barac, Aleksandra; Stevanovic, Goran; Pekmezovic, Marina; Rakocevic, Zoran; Stosovic, Rajica; Erovic, Boban; Tomic Spiric, Vesna

    2017-05-06

    Dysbiosis of the microbiome on the airway mucosa leads to the development of chronic inflammatory and allergic disorders. The aim of this study was to consider the potential diagnostic criteria for allergic fungal rhinosinusitis (AFRS) and nonallergic fungal rhinosinusitis (FRS), and the role of fungal presence in an environment for the development of AFRS. In this study, 136 patients were divided into two groups: patients with positive specific immunoglobulin E (sIgE) and fungal finding (AFRS group), and patients with negative sIgE and positive fungal finding (FRS group). The study design included: anamnesis data, sIgE, eosinophil count and skin-prick test, rhinology and computerized tomography (CT) observation and mycological finding. Our results showed: (i) the prevalence in Serbia is: AFRS 1.3%, FRS 2.8%; (ii) 30.4% patients with sIgE+ had more often severe and recurrent chronic rhinosinusitis (CRS) (P = .005) and the presence of polyps (P = .025); (iii) 46.4% patients with sIgE+ had positive fungi on the sinonasal mucosa and were considered as AFRS; (iv) patients with AFRS had more frequent asthma (P = .024) and chronicity of CRS >10 years (P = .000). The persistent fungal presence and prolonged duration of CRS could be a silent threat for the progression of inflammation and development of FRS. Lavage with hypertonic-NaCl should be included in the everyday hygiene routine in an effort to decrease fungal load and antigenic exposure. The presence of allergological parameters and better response to corticosteroid therapy in AFRS patients should be considered as crucial diagnostic criteria for AFRS. © The Author 2017. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  4. As forças transientes durante a marcha militar

    National Research Council Canada - National Science Library

    Thais Pereira Guisande; Julio Cerca Amadio; Alberto Carlos Amadio; Luis Mochizuki

    2013-01-01

    INTRODUÇÃO: O padrão vertical anormal da força de reação do solo (FRS) apresenta a assimetria ou mais de dois picos como marcha patológica típica. Uma força típica e assimétrica é a força transiente. Será...

  5. Isotopic production cross-sections and recoil velocities of spallation-fission fragments in the reaction 238U(1A GeV)+e

    CERN Document Server

    Pereira, J; Wlazlo, W; Benlliure, J; Casarejos, E; Armbruster, P; Bernas, M; Enqvist, T; Legrain, R; Leray, S; Rejmund, F; Mustapha, B; Schmidt, K.-H; Stéphan, C; Taïeb, J; Tassan-Got, L; Volant, C; Boudard, A; Czajkowski, S; 10.1103/PhysRevC.75.014602

    2007-01-01

    Fission fragments of 1A GeV 238U nuclei interacting with a deuterium target have been investigatedwith the Fragment Separator (FRS) at GSI (Darmstadt) by measuring their isotopicproduction cross-sections and recoil velocities. The results, along with those obtained recently forspallation-evaporation fragments, provide a comprehensive analysis of the spallation nuclear productionsin the reaction 238U(1A GeV)+d. Details about experiment performance, data reductionand results will be presented.

  6. Prospective post traumatic stress disorder symptom trajectories in active duty and separated military personnel

    Science.gov (United States)

    2017-01-30

    Center, San Diego, CA, USA b The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA c Teachers College, Columbia...National Health Survey of Gulf War Era Veterans and Their Families (Kang et al., 2000). Items assessing divorce, financial problems, sexual harassment...Materiel Command (Fort Detrick, MD). Support for this project was provided under Federal Interagency agreement #2012-FRS-0028 as a collaboration between

  7. PCR-based detection of Aspergillus fumigatus and absence of azole resistance due to TR34 /L98H in a french multicenter cohort of 137 patients with fungal rhinosinusitis.

    Science.gov (United States)

    Morio, Florent; Dannaoui, Eric; Chouaki, Taieb; Cateau, Estelle; Malard, Olivier; Bonfils, Pierre; Page, Cyril; Dufour, Xavier; Cottrel, Claire; Erwan, Tamic; Lavergne, Rose-Anne; Le Pape, Patrice

    2017-09-18

    Fungal rhinosinusitis (FRS) has a worldwide distribution, comprises distinct clinical entities but is mostly due to Aspergillus among which Aspergillus fumigatus plays a major role in European countries. Although, there is accumulating evidence for the emergence of environmentally acquired-azole resistance in A. fumigatus (such as TR34 /L98H) in various clinical settings, there is few data for patients with FRS. In this study, we aimed to investigate the prevalence of A. fumigatus azole resistance due to TR34 /L98H in a multicentre cohort of patients with FRS. One hundred and thirty-seven patients with FRS admitted between 2002 and 2016 at four French medical centres were retrospectively enrolled. Clinical and mycological findings were collected. Aspergillus fumigatus and the TR34 /L98H alteration conferring azole resistance were investigated directly from clinical samples using the commercial CE-IVD marked MycoGENIE(®) A. fumigatus real-time PCR assay. Fungal ball was the more frequent clinical form (n = 118). Despite the presence of fungal hyphae at direct microscopic examination, mycological cultures remained negative for 83 out of the 137 patients (60.6%). The PCR assay proved to be useful allowing the identification of A. fumigatus and etiological diagnosis in 106 patients (77.4%) compared with 44 patients (32.1%) when using culture as the reference method. Importantly, neither TR34 nor L98H alterations were evidenced. © 2017 Blackwell Verlag GmbH.

  8. The relation between non-alcoholic fatty liver disease and the risk of coronary heart disease in Koreans.

    Science.gov (United States)

    Choi, Su-Yeon; Kim, Donghee; Kim, Hwa Jung; Kang, Jin Hwa; Chung, Su Jin; Park, Min Jung; Kim, Young Sun; Kim, Chung Hyun; Choi, Seung Ho; Kim, Won; Kim, Yoon Jun; Yoon, Jung-Hwan; Lee, Hyo-Suk; Cho, Sang-Heon; Sung, Myung-Whun; Oh, Byung-Hee

    2009-08-01

    Non-alcoholic fatty liver disease (NAFLD) is known to be related to factors that predict the development of coronary heart disease (CHD), such as dyslipidemia, central obesity, and metabolic syndrome (MS). The aim of this study was to determine whether individuals with NAFLD have an elevated risk of CHD, as estimated using the Framingham risk score (FRS). A total of 21,130 individuals who underwent a voluntary general health examination were recruited. NAFLD was diagnosed among these individuals on the basis of typical sonographic findings and a level of alcohol consumption of <20 g/day. Of the 21,130 individuals, 3,780 were excluded because they had known causes of liver disease (1,690 were alcoholics, 975 had hepatitis B virus, 242 had hepatitis C virus, 91 had other hepatitis history, and 593 were taking medication known to produce fatty liver) or a history of heart disease (189). NAFLD was diagnosed in 5,769 of the 17,350 individuals (33.3%). The 11,581 normal individuals constituted the control group. The 5,769 individuals with NAFLD were split into two groups on the basis of ultrasonographic findings, that is, into a mild NAFLD group (n=3,278) and a moderate-severe NAFLD group (n=2,491). Individuals with NAFLD had an elevated risk of CHD, as estimated using FRS. Multivariable regression analysis, adjusted for confounding factors, showed a strong association between a higher FRS and NAFLD. Individuals with ultrasonographically detected NAFLD have an elevated 10-year risk of developing CHD as estimated using FRS. Furthermore, NAFLD was found to be independently related to the risk of developing CHD, regardless of classical risk factors and other components of MS.

  9. Case management to reduce risk of cardiovascular disease in a county health care system.

    Science.gov (United States)

    Ma, Jun; Berra, Kathy; Haskell, William L; Klieman, Linda; Hyde, Shauna; Smith, Mark W; Xiao, Lan; Stafford, Randall S

    2009-11-23

    Case management (CM) is a systematic approach to supplement physician-centered efforts to prevent cardiovascular disease (CVD). Research is limited on its implementation and efficacy in low-income, ethnic minority populations. We conducted a randomized clinical trial to evaluate a nurse- and dietitian-led CM program for reducing major CVD risk factors in low-income, primarily ethnic minority patients in a county health care system, 63.0% of whom had type 2 diabetes mellitus. The primary outcome was the Framingham risk score (FRS). A total of 419 patients at elevated risk of CVD events were randomized and followed up for a mean of 16 months (81.4% retention). The mean FRS was significantly lower for the CM vs usual care group at follow-up (7.80 [95% confidence interval, 7.21-8.38] vs 8.93 [8.36-9.49]; P = .001) after adjusting for baseline FRS. This is equivalent to 5 fewer heart disease events per 1000 individuals per year attributable to the intervention or to 200 individuals receiving the intervention to prevent 1 event per year. The pattern of group differences in the FRS was similar in subgroups defined a priori by sex and ethnicity. The main driver of these differences was lowering the mean (SD) systolic (-4.2 [18.5] vs 2.6 [22.7] mm Hg; P = .003) and diastolic (-6.0 [11.6] vs -3.0 [11.7] mm Hg; P = .02) blood pressures for the CM vs usual care group. Nurse and dietitian CM targeting multifactor risk reduction can lead to modest improvements in CVD risk factors among high-risk patients in low-income, ethnic minority populations receiving care in county health clinics. clinicaltrials.gov Identifier: NCT00128687.

  10. TRIGA-SPEC: the prototype of MATS and LaSpec

    Science.gov (United States)

    Kaufmann, S.; Beyer, T.; Blaum, K.; Block, M.; Düllmann, Ch E.; Eberhardt, K.; Eibach, M.; Geppert, C.; Gorges, C.; Grund, J.; Hammen, M.; Krämer, J.; Nagy, Sz; Nörtershäuser, W.; Renisch, D.; Schneider, F.; Wendt, K.

    2015-04-01

    Investigation of short-lived nuclei is a challenging task that MATS and LaSpec will handle at the low energy branch of Super-FRS at FAIR. The groundwork for those experiments is laid-out already today at the TRIGA-SPEC facility as a powerful development platform located at the research reactor TRIGA Mainz. The latest status, new developments and first results of commissioning runs are presented here.

  11. Infrared Faraday Rotation Spectroscopy for Monitoring of the atmospheric oxidation capacity

    Science.gov (United States)

    Zhao, Weixiong; Wysocki, Gerard; Chen, Weidong; Fertein, Eric; Petitprez, Denis; Zhang, Weijun

    2010-05-01

    Hydroxyl (OH) free radical is a key oxidizing species in the Earth's atmosphere. Because of its high reactivity, interference-free high sensitivity in situ monitoring of OH represents a real challenge. Faraday rotation spectroscopy (FRS) takes advantage of the particular magneto-optic effect observed for paramagnetic species. When a longitudinal magnetic field is applied, the magnetic circular birefringence is observed in the vicinity of Zeeman splitted absorption lines, and the polarization axis of a linearly polarized light is rotated due to interaction with the sample. This makes FRS capable of enhancing the detection sensitivity and completely eliminating interference from the diamagnetic species in the atmosphere such as CO2 and H2O. For OH free radicals, the highest absorption line strength and the largest gJ value make the Q (1.5) double lines of the 2Π 3-2 (ν=1←0) state at 2.8 μm clearly the best choice for sensitive detection in the infrared region by FRS. In this paper we report on the development of an FRS instrument based on a DFB diode laser operating at 2.8 μm. The prototype instrument with an active optical pathlength of only 25 cm and a lock-in time constant of 300 ms, achieves a 1σ detection limit of 3.5×1010 radicals/cm3. Substantial improvements of the instrumental components are currently ongoing and will be reported in details. Based on the conservative estimates the detection sensitivity of ~107 radicals/cm3 can be attained which is suitable for high accuracy atmospheric chemistry studies in environmental photoreactor chambers and for direct measurement of total reaction rate of OH in the atmosphere under atmospheric pressure.

  12. The determination of the radical power - an in vitro test for the evaluation of cosmetic products.

    Science.gov (United States)

    Herrling, T; Seifert, M; Sandig, G; Jung, K

    2016-06-01

    Cosmetic formulations are influenced by environmental impacts and ageing, resulting in rancidity and change of colour and structure. These changes are caused by free radicals (FRs). The sensitivity of cosmetics generating FRs is a metric for its quality and should be determined. Electron spin resonance spectroscopy in combination with UV irradiation tested cosmetics such as creams, milks, lotions and fragrances. The probes were directly measured without expensive preparation. Nine formulations are tested for its radical generation and ranked corresponding to the radical power. The transformation of the FR properties of three formulations to skin is measured by the radical skin status factor (RSF) method. It shows that the higher the radical power (RP) is, the lower the radical status RSF of skin will be. The knowledge of the sensitivity of cosmetics to generate FRs is necessary for its stabilization and prevention of potential damages to skin. It is a new way in development of cosmetics which has to be considered. © 2015 Society of Cosmetic Scientists and the Société Française de Cosmétologie.

  13. Research on the attribution evaluating methods of dynamic effects of various parameter uncertainties on the in-structure floor response spectra of nuclear power plant

    Science.gov (United States)

    Li, Jianbo; Lin, Gao; Liu, Jun; Li, Zhiyuan

    2017-01-01

    Consideration of the dynamic effects of the site and structural parameter uncertainty is required by the standards for nuclear power plants (NPPs) in most countries. The anti-seismic standards provide two basic methods to analyze parameter uncertainty. Directly manually dealing with the calculated floor response spectra (FRS) values of deterministic approaches is the first method. The second method is to perform probability statistical analysis of the FRS results on the basis of the Monte Carlo method. The two methods can only reflect the overall effects of the uncertain parameters, and the results cannot be screened for a certain parameter's influence and contribution. In this study, based on the dynamic analyses of the floor response spectra of NPPs, a comprehensive index of the assessed impact for various uncertain parameters is presented and recommended, including the correlation coefficient, the regression slope coefficient and Tornado swing. To compensate for the lack of guidance in the NPP seismic standards, the proposed method can effectively be used to evaluate the contributions of various parameters from the aspects of sensitivity, acuity and statistical swing correlations. Finally, examples are provided to verify the set of indicators from systematic and intuitive perspectives, such as the uncertainty of the impact of the structure parameters and the contribution to the FRS of NPPs. The index is sensitive to different types of parameters, which provides a new technique for evaluating the anti-seismic parameters required for NPPs.

  14. Flood Response System—A Case Study

    Directory of Open Access Journals (Sweden)

    Yogesh Kumar Singh

    2017-06-01

    Full Text Available Flood Response System (FRS is a network-enabled solution developed using open-source software. The system has query based flood damage assessment modules with outputs in the form of spatial maps and statistical databases. FRS effectively facilitates the management of post-disaster activities caused due to flood, like displaying spatial maps of area affected, inundated roads, etc., and maintains a steady flow of information at all levels with different access rights depending upon the criticality of the information. It is designed to facilitate users in managing information related to flooding during critical flood seasons and analyzing the extent of damage. The inputs to FRS are provided using two components: (1 a semi-automated application developed indigenously, to delineate inundated areas for Near-Real Time Flood Monitoring using Active Microwave Remote Sensing data and (2 a two-dimensional (2D hydrodynamic river model generated outputs for water depth and velocity in flooded areas for an embankment breach scenario. The 2D Hydrodynamic model, CCHE2D (Center for Computational Hydroscience and Engineering Two-Dimensional model, was used to simulate an area of 600 km2 in the flood-prone zone of the Brahmaputra basin. The resultant inundated area from the model was found to be 85% accurate when validated with post-flood optical satellite data.

  15. Establishment of a ternary network system for evaluating the antioxidant fraction of Danhong injection.

    Science.gov (United States)

    Wang, Yan; Jiang, Zhenzuo; Yang, Fan; Chai, Xin; Zhu, Yan; Zhao, Xiaoya; Jiang, Miaomiao; Yang, Jing; Zhao, Buchang; Qian, Ke; Wang, Yuefei

    2016-10-01

    Oxidative stress plays a crucial role in numerous cardiovascular diseases. As an effective therapy, Danhong injection (DHI) is considered to act through an antioxidant mechanism for the treatment of cardiovascular disease. In our study, we focused on the potential contribution of the antioxidant capacity of DHI fractions (Frs) and established an innovative screening method based on a 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity assay. A ternary network evaluation system, which was constructed based on the radical scavenging activity, the area under the activity-concentration curve and the solid content of the fractions, was implemented to select the fractions that posed the greatest antioxidant effect. As a result, Frs 5-7 and Frs 17-19 were shown to exhibit superior antioxidant activity according to the regression area of the ternary network, which was >0.5. Furthermore, the active fractions were characterized by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry combined with nuclear magnetic resonance. This study provided an effective method for the comprehensive evaluation of the antioxidant effect of DHI fractions. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  16. Multiple resonances of a moving, oscillating surface disturbance on a shear current

    CERN Document Server

    Li, Yan

    2016-01-01

    We consider waves radiated by a disturbance of oscillating strength moving at constant velocity along the free surface of a shear flow which, when undisturbed, has uniform horizontal vorticity of magnitude $S$. When no current is present the problem is a classical one and much studied, and in deep water a resonance is known to occur when $\\tau=|\\boldsymbol{V}|\\omega_0/g$ equals the critical value $1/4$ ($\\boldsymbol{V}$: velocity of disturbance, $\\omega_0$: oscillation frequency, $g$: gravitational acceleration). We show that the presence of the sub-surface shear current can change this picture radically. Not only does the resonant value of $\\tau$ depend strongly on the angle between $\\boldsymbol{V}$ and the current's direction and the "shear-Froude number" $\\mathrm{Frs}=|\\boldsymbol{V}|S/g$; when $\\mathrm{Frs}>1/3$, multiple resonant values --- as many as $4$ --- can occur for some directions of motion. At sufficiently large values of $\\mathrm{Frs}$, the smallest resonance frequency tends to zero, representi...

  17. Flame Retardancy of Carbon Fibre Reinforced Sorbitol Based Bioepoxy Composites with Phosphorus-Containing Additives.

    Science.gov (United States)

    Toldy, Andrea; Niedermann, Péter; Pomázi, Ákos; Marosi, György; Szolnoki, Beáta

    2017-04-27

    Carbon fibre reinforced flame-retarded bioepoxy composites were prepared from commercially available sorbitol polyglycidyl ether (SPE) cured with cycloaliphatic amine hardener. Samples containing 1, 2, and 3% phosphorus (P) were prepared using additive type flame retardants (FRs) resorcinol bis(diphenyl phosphate) (RDP), ammonium polyphosphate (APP), and their combinations. The fire performance of the composites was investigated by limiting oxygen index (LOI), UL-94 tests, and mass loss calorimetry. The effect of FRs on the glass transition temperature, and storage modulus was evaluated by dynamic mechanical analysis (DMA), while the mechanical performance was investigated by tensile, bending, and interlaminar shear measurements, as well as by Charpy impact test. In formulations containing both FRs, the presence of RDP, acting mainly in gas phase, ensured balanced gas and solid-phase mechanism leading to best overall fire performance. APP advantageously compensated the plasticizing (storage modulus and glass transition temperature decreasing) effect of RDP in combined formulations; furthermore, it led to increased tensile strength and Charpy impact energy.

  18. Stochastic and information-thermodynamic structures of population dynamics in a fluctuating environment

    Science.gov (United States)

    Kobayashi, Tetsuya J.; Sughiyama, Yuki

    2017-07-01

    Adaptation in a fluctuating environment is a process of fueling environmental information to gain fitness. Living systems have gradually developed strategies for adaptation from random and passive diversification of the phenotype to more proactive decision making, in which environmental information is sensed and exploited more actively and effectively. Understanding the fundamental relation between fitness and information is therefore crucial to clarify the limits and universal properties of adaptation. In this work, we elucidate the underlying stochastic and information-thermodynamic structure in this process, by deriving causal fluctuation relations (FRs) of fitness and information. Combined with a duality between phenotypic and environmental dynamics, the FRs reveal the limit of fitness gain, the relation of time reversibility with the achievability of the limit, and the possibility and condition for gaining excess fitness due to environmental fluctuation. The loss of fitness due to causal constraints and the limited capacity of real organisms is shown to be the difference between time-forward and time-backward path probabilities of phenotypic and environmental dynamics. Furthermore, the FRs generalize the concept of the evolutionary stable state (ESS) for fluctuating environment by giving the probability that the optimal strategy on average can be invaded by a suboptimal one owing to rare environmental fluctuation. These results clarify the information-thermodynamic structures in adaptation and evolution.

  19. Geographical modelling based on spatial differentiation of fire brigade actions: A case study of Brno, Czech Republic

    Directory of Open Access Journals (Sweden)

    Popelínský Jan

    2017-03-01

    Full Text Available The paper analyzes crisis situations solved by The Fire Rescue Service of the South Moravian Region (FRS in the city of Brno during 24 weeks between 7th April 2013 and 20th September 2013. The article deals briefly with all FRS actions and then focuses on fires. The open-access database of FRS is used for analysis. It is accessed from a database of the innovative web application StreetAlert, which allows users to learn about current fire brigade actions in the specified distance from the mobile phone. The data are processed in PostgreSQL and then spatial analysis is performed using the most detailed administrative division of the city – basic settlement units. As this division of urban space is used also in the most recent Czech census (2011, it is possible to use sociodemographic statistical data for comparison. The article identifies spatial regularities in the distribution of fires, describes the structure of the fires in terms of the type of event (fires of waste, fires of grass and forest, fires of buildings, discovers their possible dependence on the specific characteristics of urban space, finds potentially dangerous places (kernel density analysis, draws valid conclusions applicable to similar settlements, and shows the possible use of the data for local government. The main benefit of the research lies in revealing the spatial distribution of the examined phenomena.

  20. Flame Retardancy of Carbon Fibre Reinforced Sorbitol Based Bioepoxy Composites with Phosphorus-Containing Additives

    Directory of Open Access Journals (Sweden)

    Andrea Toldy

    2017-04-01

    Full Text Available Carbon fibre reinforced flame-retarded bioepoxy composites were prepared from commercially available sorbitol polyglycidyl ether (SPE cured with cycloaliphatic amine hardener. Samples containing 1, 2, and 3% phosphorus (P were prepared using additive type flame retardants (FRs resorcinol bis(diphenyl phosphate (RDP, ammonium polyphosphate (APP, and their combinations. The fire performance of the composites was investigated by limiting oxygen index (LOI, UL-94 tests, and mass loss calorimetry. The effect of FRs on the glass transition temperature, and storage modulus was evaluated by dynamic mechanical analysis (DMA, while the mechanical performance was investigated by tensile, bending, and interlaminar shear measurements, as well as by Charpy impact test. In formulations containing both FRs, the presence of RDP, acting mainly in gas phase, ensured balanced gas and solid-phase mechanism leading to best overall fire performance. APP advantageously compensated the plasticizing (storage modulus and glass transition temperature decreasing effect of RDP in combined formulations; furthermore, it led to increased tensile strength and Charpy impact energy.

  1. Performance profiles of major energy producers, 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-01-01

    The energy industry generally and petroleum and natural gas operations in particular are frequently reacting to a variety of unsettling forces. Falling oil prices, economic upswings, currency devaluations, increasingly rigorous environmental quality standards, deregulation of electricity markets, and continued advances in exploration and production technology were among the challenges and opportunities to the industry in 1997. To analyze the extent to which these and other developments have affected energy industry financial and operating performance, strategies, and industry structure, the Energy Information Administration (EIA) maintains the Financial Reporting Systems (FRS). Through Form EIA-28, major US energy companies annually report to the FRS. Financial and operating information is reported by major lines of business, including oil and gas production (upstream), petroleum refining and marketing (downstream), other energy operations, and nonenergy business. Performance Profiles of Major Producers 1997 examines the interplays of energy markets, companies` strategies, and government policies (in 1997 and in historical context) that gave rise to the results given here. The report also analyzes other key aspects of energy company financial performance as seen through the multifaceted lens provided by the FRS data and complementary data for industry overall. 41 figs., 77 tabs.

  2. PRESPEC-AGATA: New prespectives for {gamma}-spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Ameil, F.; Gerl, J.; Goel, N.; Gorska, M.; Kojouharov, I.; Pietri, S.; Schaffner, H.; Wollersheim, H.J. [GSI (Germany); Boutachkov, P.; Cortes, M.L.; Givechev, A.; Gregor, E.; Guastalla, G.; Lushta, V.; Moeller, T.; Patchakui, P.T.; Pietralla, N.; Ralet, D.; Reese, M.; Singh, P.P.; Szczepanczyk, B. [IKP, TU Darmstadt (Germany); Habermann, T. [Univ. of Frankfurt am Main (Germany); Merchan, E. [GSI (Germany); IKP, TU Darmstadt (Germany); Gadea, A. [Univ. of Valencia (Spain); Korten, W. [CEA Saclay (France); Collaboration: PRESPEC-AGATA-Collaboration

    2012-07-01

    The PRESPEC-AGATA setup is a unique combination of the GSI accelerator facility, the Fragment Separator(FRS), the Advanced Gamma Tracking Array(AGATA), the HECTOR array and the LYCCA-0 Calorimeter. With this setup high-resolution in-flight spectroscopy of relativistic({beta}{proportional_to}0.4-0.5) exotic nuclei will be performed. A thick target positioned at the final focal plane of the FRS will be used for Coulomb excitation or fragmentation of the exotic ions separated with the FRS. The {gamma}-rays emitted in these reactions will be detected by the AGATA and HECTOR arrays. The fragments produced at the secondary target will be identified and tracked by LYCCA-0. Compared to the RISING array, the improved energy resolution and efficiency of the AGATA array is expected to lead to a gain in sensitivity of a factor of 10 and 100 for {gamma}-particles and {gamma}-{gamma}-particle coincidences, respectively. The perspectives of the new setup are discussed.

  3. Coronary artery calcium scoring is a better predictor of cardiac risk in subclinical hypothyroidism patients with low-risk Framingham score

    Directory of Open Access Journals (Sweden)

    Rajesh Verma

    2016-01-01

    Full Text Available Context: Overt hypothyroidism accelerates the cardiovascular disease. Subclinical hypothyroidism (SCH, being considered as a preclinical state, impacts on cardiovascular status is not clear. Aims: This study was aimed at assessing cardiac risk stratification by Framingham risk scoring (FRS and coronary coronary artery calcium score (CACS by noncontrast cardiac computed tomography in SCH. Study Design: Observational study. Subjects and Methods: We enrolled thirty treatment-naive SCH patients (aged 30–60 years with no serious concurrent medical conditions, thirty euthyroid (age, sex, and body mass index-matched controls, and ten healthy controls. All cases were evaluated for coronary artery calcium scoring and Framingham risk score. Statistical Analysis: Qualitative data were analyzed using the Chi-square test. In addition, demographics and CACS are summarized graphically or in a table. Results: SCH cases had higher thyroglobulin, while there was a trend toward an increase in total cholesterol, low-density lipoprotein (LDL, very LDL, and decrease in HDL levels. All participants had low-risk FRS (10-year FRS < 10%. The mean CACS in SCH was significantly higher than simple obese and healthy controls (47.17 vs. 2.67 vs. 0.00. Conclusion: This study suggests that SCH is an independent risk factor for coronary artery disease in apparently healthy controls. The risk of occult coronary artery disease is increased in SCH cases.

  4. Modelling Mass Casualty Decontamination Systems Informed by Field Exercise Data

    Directory of Open Access Journals (Sweden)

    Richard Amlôt

    2012-10-01

    Full Text Available In the event of a large-scale chemical release in the UK decontamination of ambulant casualties would be undertaken by the Fire and Rescue Service (FRS. The aim of this study was to track the movement of volunteer casualties at two mass decontamination field exercises using passive Radio Frequency Identification tags and detection mats that were placed at pre-defined locations. The exercise data were then used to inform a computer model of the FRS component of the mass decontamination process. Having removed all clothing and having showered, the re-dressing (termed re-robing of casualties was found to be a bottleneck in the mass decontamination process during both exercises. Computer simulations showed that increasing the capacity of each lane of the re-robe section to accommodate 10 rather than five casualties would be optimal in general, but that a capacity of 15 might be required to accommodate vulnerable individuals. If the duration of the shower was decreased from three minutes to one minute then a per lane re-robe capacity of 20 might be necessary to maximise the throughput of casualties. In conclusion, one practical enhancement to the FRS response may be to provide at least one additional re-robe section per mass decontamination unit.

  5. Modelling Mass Casualty Decontamination Systems Informed by Field Exercise Data

    Science.gov (United States)

    Egan, Joseph R.; Amlôt, Richard

    2012-01-01

    In the event of a large-scale chemical release in the UK decontamination of ambulant casualties would be undertaken by the Fire and Rescue Service (FRS). The aim of this study was to track the movement of volunteer casualties at two mass decontamination field exercises using passive Radio Frequency Identification tags and detection mats that were placed at pre-defined locations. The exercise data were then used to inform a computer model of the FRS component of the mass decontamination process. Having removed all clothing and having showered, the re-dressing (termed re-robing) of casualties was found to be a bottleneck in the mass decontamination process during both exercises. Computer simulations showed that increasing the capacity of each lane of the re-robe section to accommodate 10 rather than five casualties would be optimal in general, but that a capacity of 15 might be required to accommodate vulnerable individuals. If the duration of the shower was decreased from three minutes to one minute then a per lane re-robe capacity of 20 might be necessary to maximise the throughput of casualties. In conclusion, one practical enhancement to the FRS response may be to provide at least one additional re-robe section per mass decontamination unit. PMID:23202768

  6. Are some "safer alternatives" hazardous as PBTs? The case study of new flame retardants.

    Science.gov (United States)

    Gramatica, Paola; Cassani, Stefano; Sangion, Alessandro

    2016-04-05

    Some brominated flame retardants (BFRs), as PBDEs, are persistent, bioaccumulative, toxic (PBT) and are restricted/prohibited under various legislations. They are replaced by "safer" flame retardants (FRs), such as new BFRs or organophosphorous compounds. However, informations on the PBT behaviour of these substitutes are often lacking. The PBT assessment is required by the REACH regulation and the PBT chemicals should be subjected to authorization. Several new FRs, proposed and already used as safer alternatives to PBDEs, are here screened by the cumulative PBT Index model, implemented in QSARINS (QSAR-Insubria), new software for the development/validation of QSAR models. The results, obtained directly from the chemical structure for the three studied characteristics altogether, were compared with those from the US-EPA PBT Profiler: the two different approaches are in good agreement, supporting the utility of a consensus approach in these screenings. A priority list of the most harmful FRs, predicted in agreement by the two modelling tools, has been proposed, highlighting that some supposed "safer alternatives" are detected as intrinsically hazardous for their PBT properties. This study also shows that the PBT Index could be a valid tool to evaluate appropriate and safer substitutes, a priori from the chemical design, in a benign by design approach, avoiding unnecessary synthesis and tests. Copyright © 2015 Elsevier B.V. All rights reserved.

  7. The Influence of Counterfactual Comparison on Fairness in Gain-Loss Contexts.

    Science.gov (United States)

    Li, Qi; Wang, Chunsheng; Taxer, Jamie; Yang, Zhong; Zheng, Ya; Liu, Xun

    2017-01-01

    Fairness perceptions may be affected by counterfactual comparisons. Although certain studies using a two-player ultimatum game (UG) have shown that comparison with the proposers influences the responders' fairness perceptions in a gain context, the effect of counterfactual comparison in a UG with multiple responders or proposers remains unclear, especially in a loss context. To resolve these issues, this study used a modified three-player UG with multiple responders in Experiment 1 and multiple proposers in Experiment 2 to examine the influence of counterfactual comparison on fairness-related decision-making in gain and loss contexts. The two experiments consistently showed that regardless of the gain or loss context, the level of inequality of the offer and counterfactual comparison influenced acceptance rates (ARs), response times (RTs), and fairness ratings (FRs). If the offers that were received were better than the counterfactual offers, unequal offers were more likely to be accepted than equal offers, and participants were more likely to report higher FRs and to make decisions more quickly. In contrast, when the offers they received were worse than the counterfactual offers, participants were more likely to reject unequal offers than equal offers, reported lower FRs, and made decisions more slowly. These results demonstrate that responders' fairness perceptions are influenced by not only comparisons of the absolute amount of money that they would receive but also specific counterfactuals from other proposers or responders. These findings improve our understanding of fairness perceptions.

  8. Vitamin D status and Framingham risk score in overweight postmenopausal women.

    Science.gov (United States)

    Truesdell, Delores; Shin, Hyehyung; Liu, Pei-Yang; Ilich, Jasminka Z

    2011-09-01

    Epidemiologic studies have suggested associations between vitamin D status and coronary heart disease (CHD) risk. The purpose of this work was to determine if vitamin D status was predictive of CHD risk assessed by Framingham risk score (FRS) in overweight, Caucasian, postmenopausal women, using the baseline data collected in a clinical trial. The study comprised 178 women aged 42-67 years (mean±standard deviation [SD] 55.7±4.3). Fasting serum was used to analyze blood lipids and vitamin D. The status of the latter was determined based on serum 25-hydroxyvitamin D [25(OH)D], with inadequacy defined as serum 25(OH)D Education, medical history, blood pressure, and anthropometric measures were obtained as well. Season was determined based on date of blood draw. Mean serum 25(OH)D concentration was 65.3±27.5 nmol/L (range 7.0-147.6 nmol/L); 66% (n=118) and 32% (n=57) of subjects were vitamin D insufficient [25(OH)D education level only. No association was observed between 25(OH)D and FRS (p=0.981). Serum 25(OH)D concentrations were inversely associated with BMI, but no relationship with FRS was found. Given the physiologic importance of vitamin D, further investigations aimed at determining the effects of obesity and heart disease on vitamin D requirements are warranted.

  9. Monitoring Conformance and Containment for Geological Carbon Storage: Can Technology Meet Policy and Public Requirements?

    Science.gov (United States)

    Lawton, D. C.; Osadetz, K.

    2014-12-01

    The Province of Alberta, Canada identified carbon capture and storage (CCS) as a key element of its 2008 Climate Change strategy. The target is a reduction in CO2 emissions of 139 Mt/year by 2050. To encourage uptake of CCS by industry, the province has provided partial funding to two demonstration scale projects, namely the Quest Project by Shell and partners (CCS), and the Alberta Carbon Trunk Line Project (pipeline and CO2-EOR). Important to commercial scale implementation of CCS will be the requirement to prove conformance and containment of the CO2 plume injected during the lifetime of the CCS project. This will be a challenge for monitoring programs. The Containment and Monitoring Institute (CaMI) is developing a Field Research Station (FRS) to calibrate various monitoring technologies for CO2 detection thresholds at relatively shallow depths. The objective being assessed with the FRS is sensitivity for early detection of loss of containment from a deeper CO2 storage project. In this project, two injection wells will be drilled to sandstone reservoir targets at depths of 300 m and 700 m. Up to four observation wells will be drilled with monitoring instruments installed. Time-lapse surface and borehole monitoring surveys will be undertaken to evaluate the movement and fate of the CO2 plume. These will include seismic, microseismic, cross well, electrical resistivity, electromagnetic, gravity, geodetic and geomechanical surveys. Initial baseline seismic data from the FRS will presented.

  10. Shock vibration and damage responses of primary auxiliary buildings from aircraft impact

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Sang Shup [Korea Atomic Energy Research Institute, 1045 Daeduk-daero, Dukjin-dong, Yuseong-gu, Daejeon 305-303 (Korea, Republic of); Department of Civil and Environmental Engineering, Hanyang University, Seoul 133-791 (Korea, Republic of); Hahm, Daegi [Korea Atomic Energy Research Institute, 1045 Daeduk-daero, Dukjin-dong, Yuseong-gu, Daejeon 305-303 (Korea, Republic of); Park, Taehyo, E-mail: cepark@hanyang.ac.kr [Department of Civil and Environmental Engineering, Hanyang University, Seoul 133-791 (Korea, Republic of)

    2016-12-15

    Highlights: • Aircraft impact analyses of PABs were performed using both the force-time history method and missile-target interaction method. • The jet fuel was considered by using the added mass modeling method and SPH method, respectively. • The FRS and the structural integrity of the external wall of the PABs against an aircraft impact were analyzed. - Abstract: Safety assessments on nuclear power plants (NPPs) subjected to an aircraft impact (AI) caused by terrorists are pivotal focuses for amelioration of present. To date, most studies have mainly focused on structure responses and the integrity of the containment building at a nuclear island (NI) subjected to AI. However, the safety assessment of internal equipment and components by shock vibration as well as the structure damage induced by AI are also important. In this study, aircraft impact analyses (AIA) of primary auxiliary buildings (PABs) were carried out using both the force–time history method and the missile–target interaction method. For the AIA, the jet fuel was taken into account by using the added mass modeling method and the smooth particles hydrodynamics (SPH) method, respectively. In addition, the floor response spectra (FRS) and the structural integrity of the external wall of the PAB against an AI were analyzed. Finally, the difference in the FRS at the location of the components on both sides of the bay was analyzed.

  11. Poultry enteric inflammation model with dextran sodium sulfate mediated chemical induction and feed restriction in broilers.

    Science.gov (United States)

    Kuttappan, V A; Berghman, L R; Vicuña, E A; Latorre, J D; Menconi, A; Wolchok, J D; Wolfenden, A D; Faulkner, O B; Tellez, G I; Hargis, B M; Bielke, L R

    2015-06-01

    Gut inflammation is a cardinal event occurring in various gastrointestinal diseases regardless of etiology. A potential mechanism of action for antibiotic growth promoters and probiotics is alleviation or attenuation of such inflammation. In vivo inflammation models and markers to quantify changes in inflammation, such as paracellular leakage and tight junction function, are necessary tools in the search for methods to reduce enteric inflammation. Dextran sodium sulfate (DSS) and feed restriction (FRS), and fluorescein isothiocyanate dextran (FITC-d; 3 to 5 kDa) marker were evaluated for induction and assessment of enteric inflammation in broilers. Three independent experiments were conducted where birds received an inflammation inducer treatment and an oral gavage of FITC-d (2.2 mg/bird) 2.5 h before killing on d 4, followed by measurement of serum FITC-d levels and release of FITC-d from different regions of gastrointestinal tract (GIT) to evaluate tight junction function. Experiment 1 tested control (CON) and DSS; Experiments 2 and 3 evaluated CON, DSS, and FRS. In all experiments DSS, as well as FRS in Experiments 2 and 3, showed higher (PPoultry Science Association Inc.

  12. Breeding objectives for indigenous chicken: model development and application to different production systems.

    Science.gov (United States)

    Okeno, Tobias O; Magothe, Thomas M; Kahi, Alexander K; Peters, Kurt J

    2013-01-01

    A bio-economic model was developed to evaluate the utilisation of indigenous chickens (IC) under different production systems accounting for the risk attitude of the farmers. The model classified the production systems into three categories based on the level of management: free-range system (FRS), where chickens were left to scavenge for feed resources with no supplementation and healthcare; intensive system (IS), where the chickens were permanently confined and supplied with rationed feed and healthcare; and semi-intensive system (SIS), a hybrid of FRS and IS, where the chickens were partially confined, supplemented with rationed feeds, provided with healthcare and allowed to scavenge within the homestead or in runs. The model allows prediction of the live weights and feed intake at different stages in the life cycle of the IC and can compute the profitability of each production system using both traditional and risk-rated profit models. The input parameters used in the model represent a typical IC production system in developing countries but are flexible and therefore can be modified to suit specific situations and simulate profitability and costs of other poultry species production systems. The model has the capability to derive the economic values as changes in the genetic merit of the biological parameter results in marginal changes in profitability and costs of the production systems. The results suggested that utilisation of IC in their current genetic merit and production environment is more profitable under FRS and SIS but not economically viable under IS.

  13. Women at risk for cardiovascular disease lack knowledge of heart attack symptoms.

    Science.gov (United States)

    Flink, Laura E; Sciacca, Robert R; Bier, Michael L; Rodriguez, Juviza; Giardina, Elsa-Grace V

    2013-03-01

    It is not known whether cardiovascular disease (CVD) risk level is related to knowledge of the leading cause of death of women or heart attack symptoms. Women with higher CVD risk estimated by Framingham Risk Score (FRS) or metabolic syndrome (MS) have lower CVD knowledge. Women visiting primary care clinics completed a standardized behavioral risk questionnaire. Blood pressure, weight, height, waist size, fasting glucose, and lipid profile were assessed. Women were queried regarding CVD knowledge. Participants (N = 823) were Hispanic women (46%), non-Hispanic white (37%), and non-Hispanic black (8%). FRS was determined in 278: low (63%), moderate (29%), and high (8%); 24% had ≥3 components of MS. The leading cause of death was answered correctly by 54%, heart attack symptoms by 67%. Knowledge was lowest among racial/ethnic minorities and those with less education (both Pheart attack symptoms (P = 0.018), but not after multivariable adjustment. Women with higher FRS were less likely to know heart attack symptoms. Efforts to target those at higher CVD risk must persist, or the most vulnerable may suffer disproportionately, not only because of risk factors but also inadequate knowledge. © 2013 Wiley Periodicals, Inc.

  14. Master Metadata Repository and Metadata-Management System

    Science.gov (United States)

    Armstrong, Edward; Reed, Nate; Zhang, Wen

    2007-01-01

    A master metadata repository (MMR) software system manages the storage and searching of metadata pertaining to data from national and international satellite sources of the Global Ocean Data Assimilation Experiment (GODAE) High Resolution Sea Surface Temperature Pilot Project [GHRSSTPP]. These sources produce a total of hundreds of data files daily, each file classified as one of more than ten data products representing global sea-surface temperatures. The MMR is a relational database wherein the metadata are divided into granulelevel records [denoted file records (FRs)] for individual satellite files and collection-level records [denoted data set descriptions (DSDs)] that describe metadata common to all the files from a specific data product. FRs and DSDs adhere to the NASA Directory Interchange Format (DIF). The FRs and DSDs are contained in separate subdatabases linked by a common field. The MMR is configured in MySQL database software with custom Practical Extraction and Reporting Language (PERL) programs to validate and ingest the metadata records. The database contents are converted into the Federal Geographic Data Committee (FGDC) standard format by use of the Extensible Markup Language (XML). A Web interface enables users to search for availability of data from all sources.

  15. The Influence of Counterfactual Comparison on Fairness in Gain-Loss Contexts

    Directory of Open Access Journals (Sweden)

    Qi Li

    2017-05-01

    Full Text Available Fairness perceptions may be affected by counterfactual comparisons. Although certain studies using a two-player ultimatum game (UG have shown that comparison with the proposers influences the responders' fairness perceptions in a gain context, the effect of counterfactual comparison in a UG with multiple responders or proposers remains unclear, especially in a loss context. To resolve these issues, this study used a modified three-player UG with multiple responders in Experiment 1 and multiple proposers in Experiment 2 to examine the influence of counterfactual comparison on fairness-related decision-making in gain and loss contexts. The two experiments consistently showed that regardless of the gain or loss context, the level of inequality of the offer and counterfactual comparison influenced acceptance rates (ARs, response times (RTs, and fairness ratings (FRs. If the offers that were received were better than the counterfactual offers, unequal offers were more likely to be accepted than equal offers, and participants were more likely to report higher FRs and to make decisions more quickly. In contrast, when the offers they received were worse than the counterfactual offers, participants were more likely to reject unequal offers than equal offers, reported lower FRs, and made decisions more slowly. These results demonstrate that responders' fairness perceptions are influenced by not only comparisons of the absolute amount of money that they would receive but also specific counterfactuals from other proposers or responders. These findings improve our understanding of fairness perceptions.

  16. Analysis of Seismic Soil-Structure Interaction for a Nuclear Power Plant (HTR-10

    Directory of Open Access Journals (Sweden)

    Xiaoxin Wang

    2017-01-01

    Full Text Available The response of nuclear power plants (NPPs to seismic events is affected by soil-structure interactions (SSI. In the present paper, a finite element (FE model with transmitting boundaries is used to analyse the SSI effect on the response of NPP buildings subjected to vertically incident seismic excitation. Analysis parameters that affect the accuracy of the calculations, including the dimension of the domain and artificial boundary types, are investigated through a set of models. A numerical SSI analysis for the 10 MW High Temperature Gas Cooled Test Reactor (HTR-10 under seismic excitation was carried out using the developed model. The floor response spectra (FRS produced by the SSI analysis are compared with a fixed-base model to investigate the SSI effect on the dynamic response of the reactor building. The results show that the FRS at foundation level are reduced and those at higher floor levels are altered significantly when taking SSI into account. The peak frequencies of the FRS are reduced due to the SSI, whereas the acceleration at high floor levels is increased at a certain frequency range. The seismic response of the primary system components, however, is reduced by the analysed SSI for the HTR-10 on the current soil site.

  17. High-Throughput, Protein-Targeted Biomolecular Detection Using Frequency-Domain Faraday Rotation Spectroscopy.

    Science.gov (United States)

    Murdock, Richard J; Putnam, Shawn A; Das, Soumen; Gupta, Ankur; Chase, Elyse D Z; Seal, Sudipta

    2017-03-01

    A clinically relevant magneto-optical technique (fd-FRS, frequency-domain Faraday rotation spectroscopy) for characterizing proteins using antibody-functionalized magnetic nanoparticles (MNPs) is demonstrated. This technique distinguishes between the Faraday rotation of the solvent, iron oxide core, and functionalization layers of polyethylene glycol polymers (spacer) and model antibody-antigen complexes (anti-BSA/BSA, bovine serum albumin). A detection sensitivity of ≈10 pg mL(-1) and broad detection range of 10 pg mL(-1) ≲ cBSA ≲ 100 µg mL(-1) are observed. Combining this technique with predictive analyte binding models quantifies (within an order of magnitude) the number of active binding sites on functionalized MNPs. Comparative enzyme-linked immunosorbent assay (ELISA) studies are conducted, reproducing the manufacturer advertised BSA ELISA detection limits from 1 ng mL(-1) ≲ cBSA ≲ 500 ng mL(-1) . In addition to the increased sensitivity, broader detection range, and similar specificity, fd-FRS can be conducted in less than ≈30 min, compared to ≈4 h with ELISA. Thus, fd-FRS is shown to be a sensitive optical technique with potential to become an efficient diagnostic in the chemical and biomolecular sciences. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. Sine ars scientia nihil est: Leonardo da Vinci and beyond.

    Science.gov (United States)

    Kickhöfel, Eduardo H P

    2009-01-01

    The aim of this article is to reflect on the relationship between art and science so far as it concerns a symposium on neurosciences. We undertake a historical overview of that relationship, paying particular attention to the sui generis case of Leonardo da Vinci, who very often is regarded as the man who worked on art and science with equal ease. We then explain why his idea of merging these two forms of knowledge failed, considering the clear-cut distinction between art and science in his time. With this clarification, we explore the matter today. We look at Raphael's The Transfiguration, in which the representation of the possessed boy is seen by neuroscientists as indicative of an epileptic seizure. We also look at the ideas of neuroscientists Semir Zeki and Vilayanur Ramachandran, who study particular aspects of brain function and suggest a new merging of art and science.

  19. Terrorism as Genocide: Killing with “Intent”

    Directory of Open Access Journals (Sweden)

    Ashlie Perry

    2012-07-01

    Full Text Available It is plausible that terrorism can manifest itself as a form of genocide. Using Raphael Lemkin’s definition of genocide and the UN Genocide Convention’s definition of genocide, non-state and state terrorism are assessed as a form of genocide. Commonalities found in the definitions of both genocide and terrorism supports the argument. The psychology of terrorism and Lemkin’s psychology of genocide describe similar motivations of perpetrators. The September 11th attacks and the U.S. invasion of Iraq are used as case studies to illustrate that terrorism can result in genocide or genocidal acts. Framing acts of terrorism as genocide allows for prosecution in international courts and brings a new perspective to the concept of killing with intent.

  20. Neuroscience in Nazi Europe Part III: victims of the Third Reich.

    Science.gov (United States)

    Zeidman, Lawrence A; Kondziella, Daniel

    2012-11-01

    In Part I, neuroscience collaborators with the Nazis were discussed, and in Part II, neuroscience resistors were discussed. In Part III, we discuss the tragedy regarding european neuroscientists who became victims of the Nazi onslaught on “non-Aryan” doctors. Some of these unfortunate neuroscientists survived Nazi concentration camps, but most were murdered. We discuss the circumstances and environment which stripped these neuroscientists of their profession, then of their personal rights and freedom, and then of their lives. We include a background analysis of anti-Semitism and Nazism in their various countries, then discuss in depth seven exemplary neuroscientist Holocaust victims; including Germans Ludwig Pick, Arthur Simons, and Raphael Weichbrodt, Austrians Alexander Spitzer and Viktor Frankl, and Poles Lucja Frey and Wladyslaw Sterling. by recognizing and remembering these victims of neuroscience, we pay homage and do not allow humanity to forget, lest this dark period in history ever repeat itself.

  1. Paradise Lost Dressed in the Costume of History: John Martin’s Rendition of Paradise Lost

    Directory of Open Access Journals (Sweden)

    Laleh Atashi

    2011-01-01

    Full Text Available The story of the loss of paradise has been read and interpreted in different ages. Commentary on Milton's Paradise Lost is not limited to verbal texts; painters and illustrators have contributed greatly to the poem by presenting their own time-bound readings and interpretations of the poem through their illustrations that are far beyond mere decorations. John Martin, in the aftermath of the Industrial Revolution, deletes the Father and the Son from his illustrations. Only angels such as Raphael are the representations of deity and are as powerless and tiny as Adam and Eve. Adam and Eve, after the Fall seem as small, powerless and as subjugated to the natural surrounding as they were before the Fall. Satan is the only powerful figure in his elegant palace. Through a new historical outlook, the researchers aim at exposing the workings of ideology and dominant discourses that informed John Martin's pictorial reading of Milton's poem in the early 19th century

  2. Modelling floods in the Ammer catchment: limitations and challenges with a coupled meteo-hydrological model approach

    Directory of Open Access Journals (Sweden)

    R. Ludwig

    2003-01-01

    Full Text Available Numerous applications of hydrological models have shown their capability to simulate hydrological processes with a reasonable degree of certainty. For flood modelling, the quality of precipitation data — the key input parameter — is very important but often remains questionable. This paper presents a critical review of experience in the EU-funded RAPHAEL project. Different meteorological data sources were evaluated to assess their applicability for flood modelling and forecasting in the Bavarian pre-alpine catchment of the Ammer river (709 km2, for which the hydrological aspects of runoff production are described as well as the complex nature of floods. Apart from conventional rain gauge data, forecasts from several Numerical Weather Prediction Models (NWP as well as rain radar data are examined, scaled and applied within the framework of a GIS-structured and physically based hydrological model. Multi-scenario results are compared and analysed. The synergetic approach leads to promising results under certain meteorological conditions but emphasises various drawbacks. At present, NWPs are the only source of rainfall forecasts (up to 96 hours with large spatial coverage and high temporal resolution. On the other hand, the coarse spatial resolution of NWP grids cannot yet address, adequately, the heterogeneous structures of orographic rainfields in complex convective situations; hence, a major downscaling problem for mountain catchment applications is introduced. As shown for two selected Ammer flood events, a high variability in prediction accuracy has still to be accepted at present. Sensitivity analysis of both meteo-data input and hydrological model performance in terms of process description are discussed and positive conclusions have been drawn for future applications of an advanced meteo-hydro model synergy. Keywords: RAPHAEL, modelling, forecasting, model coupling, PROMET-D, TOPMODEL

  3. Cardiovascular Risk Burden and Future Risk of Walking Speed Limitation in Older Adults.

    Science.gov (United States)

    Heiland, Emerald G; Qiu, Chengxuan; Wang, Rui; Santoni, Giola; Liang, Yajun; Fratiglioni, Laura; Welmer, Anna-Karin

    2017-11-01

    To explore the association between cardiovascular risk factor (CRF) burden and limitation in walking speed, balance, and chair stand and to verify whether these associations vary according to age and cognitive status. Longitudinal population-based study. Urban area of Stockholm, Sweden. Individuals aged 60 and older who participated in the Swedish National Study on Aging and Care in Kungsholmen and were free of limitations in walking speed (n = 1,441), balance (n = 1,154), or chair stands (n = 1,496) at baseline (2001-04). At baseline, data on demographic characteristics, CRFs, other lifestyle factors, C-reactive protein, and cognitive function were collected. CRF burden was measured using the Framingham general cardiovascular risk score (FRS). Limitations in walking speed (<0.8 m/s), balance (<5 seconds), and chair stand (inability to rise 5 times) were determined at 3-, 6-, and 9-year follow-up. Data were analyzed using Cox proportional hazards models stratified according to age (<78, ≥78). During follow-up, 326 persons developed limitations in walking speed, 303 in balance, and 374 in chair stands. An association between the FRS and walking speed limitation was evident only in adults younger than 78 (for each 1-point increase in FRS: hazard ratio (HR) = 1.09, 95% confidence interval (CI) = 1.02-1.17) after controlling for potential confounders including cognitive function (correspondingly, in adults aged ≥78: HR = 0.98, 95% CI = 0.92-1.03). Also, higher FRS was significantly associated with faster decline in walking speed (P < .001). A higher FRS is associated with greater risk of subsequent development of walking speed limitation in adults younger than 78, independent of cognitive function. Interventions targeting multiple CRFs in younger-old people may help in maintaining mobility function. © 2017, Copyright the Authors Journal compilation © 2017, The American Geriatrics Society.

  4. Hemoglobin A1c Is Positively Correlated with Framingham Risk Score in Older, Apparently Healthy Nondiabetic Korean Adults

    Directory of Open Access Journals (Sweden)

    Ji Hye Shin

    2013-06-01

    Full Text Available BackgroundSeveral studies have suggested that elevated levels of hemoglobin A1c (HbA1c are associated with cardiovascular disease (CVD in nondiabetic individuals. However, it is unclear whether HbA1c levels can serve as a simple screening marker for increased CVD risk in nondiabetic individuals. Our objective was to evaluate the relationship between HbA1c levels and CVD risk using the Framingham risk score (FRS in older, apparently healthy nondiabetic Korean adults.MethodsWe retrospectively studied 2,879 Korean adults between the ages of 40 and 79 who underwent voluntary health check-ups at the Health Promotion Center of our hospital from July 2009 to June 2011. Subjects were subdivided based on their HbA1c levels into four groups: tertiles within the HbA1c normal tolerance range and a group for subjects with an increased risk for diabetes (IRD.ResultsThe mean FRS for the upper tertile (9.6±3.8 group was significantly higher than that of the middle tertile (8.4±4.0 and lower tertile (7.6±3.8 groups. In addition, FRS was highest in the IRD group (10.5±3.7. Multiple linear regression analysis demonstrated that HbA1c levels exhibited a significant positive correlation with FRS when adjusted for confounding variables in all subjects (β±standard error [SE], 0.018±0.002; R2, 0.131, women (β±SE, 0.023±0.003; R2, 0.170, and men (β±SE, 0.016±0.004; R2, 0.109.ConclusionHbA1c levels were positively correlated with FRS in older, apparently healthy nondiabetic Korean adults. We propose that HbA1c levels may reflect CVD risk in nondiabetic individuals.

  5. Formulation, release characteristics, and bioavailability study of gastroretentive floating matrix tablet and floating raft system of Mebeverine HCl

    Directory of Open Access Journals (Sweden)

    El Nabarawi MA

    2017-04-01

    Full Text Available Mohamed A El Nabarawi,1 Mahmoud H Teaima,1 Rehab A Abd El-Monem,2 Nagla A El Nabarawy,3 Dalia A Gaber4 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt; 2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Misr University for Science and Technology, 6th of October, Egypt; 3National Egyptian Center of Environment and Toxicological Research (NECTER, Faculty of Medicine, Cairo University, Cairo, Egypt; 4Department of Quality Control, Holding Company for Biological Products and Vaccines, Cairo, Egypt Abstract: To prolong the residence time of dosage forms within the gastrointestinal tract until all drug is released at the desired rate is one of the real challenges for oral controlled-release drug delivery systems. This study was designed to develop a controlled-release floating matrix tablet and floating raft system of Mebeverine HCl (MbH and evaluate different excipients for their floating behavior and in vitro controlled-release profiles. Oral pharmacokinetics of the optimum matrix tablet, raft system formula, and marketed Duspatalin® 200 mg retard as reference were studied in beagle dogs. The optimized tablet formula (FT-10 and raft system formula (FRS-11 were found to float within 34±5 sec and 15±7 sec, respectively, and both remain buoyant over a period of 12 h in simulated gastric fluid. FT-10 (Compritol/HPMC K,100M 1:1 showed the slowest drug release among all prepared tablet formulations, releasing about 80.2% of MbH over 8 h. In contrast, FRS-11 (Sodium alginate 3%/HPMC K,100M 1%/Precirol 2% had the greatest retardation, providing sustained release of 82.1% within 8 h. Compared with the marketed MbH product, the Cmax of FT-10 was almost the same, while FRS-11 maximum concentration was higher. The tmax was 3.33, 2.167, and 3.0 h for marketed MbH product, FT-10, and FRS-11, respectively. In addition, the oral bioavailability experiment showed that the relative

  6. A comparison of live counseling with a web-based lifestyle and medication intervention to reduce coronary heart disease risk: a randomized clinical trial.

    Science.gov (United States)

    Keyserling, Thomas C; Sheridan, Stacey L; Draeger, Lindy B; Finkelstein, Eric A; Gizlice, Ziya; Kruger, Eliza; Johnston, Larry F; Sloane, Philip D; Samuel-Hodge, Carmen; Evenson, Kelly R; Gross, Myron D; Donahue, Katrina E; Pignone, Michael P; Vu, Maihan B; Steinbacher, Erika A; Weiner, Bryan J; Bangdiwala, Shrikant I; Ammerman, Alice S

    2014-07-01

    Most primary care clinicians lack the skills and resources to offer effective lifestyle and medication (L&M) counseling to reduce coronary heart disease (CHD) risk. Thus, effective and feasible CHD prevention programs are needed for typical practice settings. To assess the effectiveness, acceptability, and cost-effectiveness of a combined L&M intervention to reduce CHD risk offered in counselor-delivered and web-based formats. A comparative effectiveness trial in 5 diverse family medicine practices in North Carolina. Participants were established patients, aged 35 to 79 years, with no known cardiovascular disease, and at moderate to high risk for CHD (10-year Framingham Risk Score [FRS], ≥10%). Participants were randomized to counselor-delivered or web-based format, each including 4 intensive and 3 maintenance sessions. After randomization, both formats used a web-based decision aid showing potential CHD risk reduction associated with L&M risk-reducing strategies. Participants chose the risk-reducing strategies they wished to follow. The primary outcome was within-group change in FRS at 4-month follow-up. Other measures included standardized assessments of blood pressure, blood lipid levels, lifestyle behaviors, and medication adherence. Acceptability and cost-effectiveness were also assessed. Outcomes were assessed at 4 and 12 months. Of 2274 screened patients, 385 were randomized (192 counselor; 193 web): mean age, 62 years; 24% African American; and mean FRS, 16.9%. Follow-up at 4 and 12 months included 91% and 87% of the randomized participants, respectively. There was a sustained reduction in FRS at both 4 months (primary outcome) and 12 months for both counselor-based (-2.3% [95% CI, -3.0% to -1.6%] and -1.9% [95% CI, -2.8% to -1.1%], respectively) and web-based groups (-1.5% [95% CI, -2.2% to -0.9%] and -1.7% [95% CI, -2.6% to -0.8%] respectively). At 4 months, the adjusted difference in FRS between groups was -1.0% (95% CI, -1.8% to -0.1%) (P = .03

  7. Biossensor enzimático para detecção de fungicidas ditiocarbamatos: estudo cinético da enzima aldeído desidrogenase e otimização do biossensor Enzymatic biosensor for the detection of dithiocarbamate fungicides: kinetic study of aldehyde dehydrogenase enzyme and biosensor optimization

    Directory of Open Access Journals (Sweden)

    Roberval Soares Lima

    2007-02-01

    Full Text Available Initially, all major factors that affect the rate of the AldH-catalyzed reaction (enzyme concentration, substrate concentration, temperature and pH were investigated. Optimal activity was observed between pH values of 7.5 and 9.5 in the temperature range of 25 to 50 ºC. Kinetic parameters, such as Km (2.92 µmol L-1 and Vmax (1.33 10-2 µmol min-1 demonstrate a strong enzyme-substrate affinity. The sensors were based on screen-printed electrodes modified with the Meldola Blue-Reinecke salt (MBRS combination. Operational conditions (NAD+ and substrate contents, enzyme loading and response time were optimized. Also, two enzyme immobilization procedures were tested: entrapment in poly(vinyl alcohol bearing styrylpyridinium groups (PVA-SbQ and crosslinking with glutaraldehyde. Chronoamperometry was employed to observe the biosensor responses during enzymatic hydrolysis of propionaldehyde and also to construct inhibition curves with maneb and zineb fungicides. Best results were found with the following conditions: [NAD+] = 0.25 mmol L-1; [propionaldehyde] = 80 µmol L-1; enzyme loading = 0.8 U per electrode; response time = 10 min, and inhibition time = 10 min. Current intensities around 103 ± 13 nA with the sensors and good stability was obtained for both immobilization procedures. Detection limits, calculated using 10% inhibition were 31.5 µg L-1 and 35 µg L-1 for maneb and zineb, respectively. Results obtained with other MBRS-modified electrodes consisting of mono and bi-enzymic sensors were compared. The ability to catalyze NADH oxidation by MB was also highlighted.

  8. Purification and characterization of cellobiose dehydrogenase from the plant pathogen Sclerotium (Athelia) rolfsii.

    Science.gov (United States)

    Baminger, U; Subramaniam, S S; Renganathan, V; Haltrich, D

    2001-04-01

    Cellobiose dehydrogenase (CDH) is an extracellular hemoflavoenzyme produced by several wood-degrading fungi. In the presence of a suitable electron acceptor, e.g., 2,6-dichloro-indophenol (DCIP), cytochrome c, or metal ions, CDH oxidizes cellobiose to cellobionolactone. The phytopathogenic fungus Sclerotium rolfsii (teleomorph: Athelia rolfsii) strain CBS 191.62 produces remarkably high levels of CDH activity when grown on a cellulose-containing medium. Of the 7,500 U of extracellular enzyme activity formed per liter, less than 10% can be attributed to the proteolytic product cellobiose:quinone oxidoreductase. As with CDH from wood-rotting fungi, the intact, monomeric enzyme from S. rolfsii contains one heme b and one flavin adenine dinucleotide cofactor per molecule. It has a molecular size of 101 kDa, of which 15% is glycosylation, and a pI value of 4.2. The preferred substrates are cellobiose and cellooligosaccharides; additionally, beta-lactose, thiocellobiose, and xylobiose are efficiently oxidized. Cytochrome c (equine) and the azino-di-(3-ethyl-benzthiazolin-6-sulfonic acid) cation radical were the best electron acceptors, while DCIP, 1,4-benzoquinone, phenothiazine dyes such as methylene blue, phenoxazine dyes such as Meldola's blue, and ferricyanide were also excellent acceptors. In addition, electrons can be transferred to oxygen. Limited in vitro proteolysis with papain resulted in the formation of several protein fragments that are active with DCIP but not with cytochrome c. Such a flavin-containing fragment, with a mass of 75 kDa and a pI of 5.1 and lacking the heme domain, was isolated and partially characterized.

  9. A novel microassay for measuring blood alcohol concentration using a disposable biosensor strip.

    Science.gov (United States)

    Zhen, Shenghang; Wang, Yan; Liu, Chenggui; Xie, Guoming; Zou, Chaoshi; Zheng, Jun; Zhu, Yang

    2011-04-15

    A novel disposable amperometric biosensor strip for determination of blood alcohol concentration (BAC) with small volume of sample has been constructed using screen-printed electrodes (SPE), nanocomposite film and alcohol dehydrogenase (ADH). Firstly, the GNPs-MWCNT-Nafion nanocomposite film modified on a working electrode was made of Nafion-117, multi-wall carbon nanotubes (MWCNT) and gold nanoparticles (GNPs). After that Meldola's blue (MB) acted as an electron transfer mediator and the mixed solution of ADH, nicotinamide adenine dinucleotide (NAD(+)) were modified in order on the nanocomposite film. At last, a hydrophilic membrane which had an eyehole in center was placed at the outermost of the working area to make a reaction tank of 5 μL, then the hydrophilic membrane/ADH-NAD(+)/GNPs-MWCNT-MB-Nafion/SPE was prepared. The detection of BAC can be accomplished with 5 μL of blood sample obtained precisely by siphonage. Optimum conditions of the biosensor were experimentally determined by varying several important parameters: working potential, solution pH value, environmental temperature and interferences. Experimental results indicated that the biosensor possessed a good accuracy and stability, the linear response range was 2.0 × 10(-4) to 25 × 10(-3)mol/L and the detection limit of the biosensor was 5.0 × 10(-5)mol/L (S/N=3). In the measurement of blood samples, the proposed biosensor had excellent detection performance for measuring BAC and showed a good correlation with gas chromatography. The prepared biosensor strip can be valid for the analysis of BAC. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  10. Systems Analysis of an Advanced Nuclear Fuel Cycle Based on a Modified UREX+3c Process

    Energy Technology Data Exchange (ETDEWEB)

    E. R. Johnson; R. E. Best

    2009-12-28

    The research described in this report was performed under a grant from the U.S. Department of Energy (DOE) to describe and compare the merits of two advanced alternative nuclear fuel cycles -- named by this study as the “UREX+3c fuel cycle” and the “Alternative Fuel Cycle” (AFC). Both fuel cycles were assumed to support 100 1,000 MWe light water reactor (LWR) nuclear power plants operating over the period 2020 through 2100, and the fast reactors (FRs) necessary to burn the plutonium and minor actinides generated by the LWRs. Reprocessing in both fuel cycles is assumed to be based on the UREX+3c process reported in earlier work by the DOE. Conceptually, the UREX+3c process provides nearly complete separation of the various components of spent nuclear fuel in order to enable recycle of reusable nuclear materials, and the storage, conversion, transmutation and/or disposal of other recovered components. Output of the process contains substantially all of the plutonium, which is recovered as a 5:1 uranium/plutonium mixture, in order to discourage plutonium diversion. Mixed oxide (MOX) fuel for recycle in LWRs is made using this 5:1 U/Pu mixture plus appropriate makeup uranium. A second process output contains all of the recovered uranium except the uranium in the 5:1 U/Pu mixture. The several other process outputs are various waste streams, including a stream of minor actinides that are stored until they are consumed in future FRs. For this study, the UREX+3c fuel cycle is assumed to recycle only the 5:1 U/Pu mixture to be used in LWR MOX fuel and to use depleted uranium (tails) for the makeup uranium. This fuel cycle is assumed not to use the recovered uranium output stream but to discard it instead. On the other hand, the AFC is assumed to recycle both the 5:1 U/Pu mixture and all of the recovered uranium. In this case, the recovered uranium is reenriched with the level of enrichment being determined by the amount of recovered plutonium and the combined amount

  11. As forças transientes durante a marcha militar

    Directory of Open Access Journals (Sweden)

    Thais Pereira Guisande

    2013-12-01

    Full Text Available INTRODUÇÃO: O padrão vertical anormal da força de reação do solo (FRS apresenta a assimetria ou mais de dois picos como marcha patológica típica. Uma força típica e assimétrica é a força transiente. Será que a marcha militar é uma espécie de marcha patológica? OBJETIVO: Descrever e analisar a força de reação do solo vertical durante a fase de apoio da marcha militar. MÉTODO: Os participantes foram 20 soldados do Exército Brasileiro que tiveram anteriormente uma lesão nos membros inferiores relacionada com a marcha militar. Duas plataformas de força foram usadas para medir as componentes da FRS (mediolateral, anteroposterior e vertical durante a marcha. Para cada lado e condição (andar e marcha, cinco amostras para cada pé foram registradas. A análise de variância foi utilizada para comparar os parâmetros da FRS durante o andar e marcha. RESULTADO: O primeiro pico de força foi o mais alto durante a condição de marcha. O pico de força transiente durante a marcha foi maior que o primeiro pico durante o andar. A força mínima foi a maior durante a marcha. CONCLUSÃO: A análise das forças de reação do solo marcha militar mostra uma força vertical transiente que não está normalmente presente no padrão de marcha normal.

  12. Reduction in predicted coronary heart disease risk after substantial weight reduction after bariatric surgery.

    Science.gov (United States)

    Vogel, Jody A; Franklin, Barry A; Zalesin, Kerstyn C; Trivax, Justin E; Krause, Kevin R; Chengelis, David L; McCullough, Peter A

    2007-01-15

    In recent years, bariatric surgery has become an increasingly used therapeutic option for morbid obesity. The effect of weight loss after bariatric surgery on the predicted risk of coronary heart disease (CHD) has not previously been studied. We evaluated baseline (preoperative) and follow-up (postoperative) body mass index, CHD risk factors, and Framingham risk scores (FRSs) for 109 consecutive patients with morbid obesity who lost weight after laparoscopic Roux-en-Y gastric bypass surgery. Charts were abstracted using a case-report form by a reviewer blinded to the FRS results. The study included 82 women (75%) and 27 men (25%) (mean age 46 +/- 10 years). Mean body mass index values at baseline and follow-up were 49 +/- 8 and 36 +/- 8 kg/m(2), respectively (p <0.0001). During an average follow-up of 17 months, diabetes, hypertension, and dyslipidemia resolved or improved after weight loss. Thus, the risks of CHD as predicted by FRS decreased by 39% in men and 25% in women. The predicted 10-year CHD risks at baseline and follow-up were 6 +/- 5% and 4 +/- 3%, respectively (p < or =0.0001). For those without CHD, men compared favorably with the age-matched general population, with a final 10-year risk of 5 +/- 4% versus an expected risk of 11 +/- 6% (p <0.0001). Likewise, women achieved a level below the age-adjusted expected 10-year risk of the general population, with a final risk of 3 +/- 3% versus 6 +/- 4% (p <0.0001). In conclusion, weight loss results in a significant decrease in FRS 10-year predicted CHD risk. Bariatric surgery decreases CHD risk to rates lower than the age- and gender-adjusted estimates for the general population. These data suggest substantial and sustained weight loss after bariatric surgery may be a powerful intervention to decrease future rates of myocardial infarction and death in the morbidly obese.

  13. Subclinical cardiovascular disease in postmenopausal women with low/medium cardiovascular risk by the Framingham risk score.

    Science.gov (United States)

    Maturana, Maria Augusta; Franz, Roberta Fernandez; Metzdorf, Marcela; da Silva, Thais Rasia; Spritzer, Poli Mara

    2015-06-01

    To evaluate the prevalence of subclinical cardiovascular disease (CVD) and its association with clinical and hormone variables in postmenopausal women from Southern Brazil. Cross-sectional study. Coronary artery calcification (CAC) assessed by electron-beam computed tomography. Carotid intima-media thickness (IMT) and atheromatous plaques assessed using B-mode ultrasound. IMT was measured at three segments. Subclinical CVD was defined as the presence of plaque and/or IMT >0.9 mm. Ninety-seven postmenopausal women (mean age 55 ± 5 years, median duration of menopause 5.8 [3-10] years) were studied. A low/medium Framingham risk score (FRS) was present in 97.9% of participants; 35.1% had subclinical CVD on carotid ultrasound, and 24.7% had the presence of plaque. Seven women had a CAC score ≥ 100, and two had a score ≥ 200. CAC score (p<0.001) and FRS (p=0.013) were higher in patients with subclinical atherosclerosis. Positive correlations were found between IMT and age (rs=0.293 p=0.004), duration of menopause (rs=0.237, p=0.020), and CAC score (rs=0.468, p<0.001). Common carotid IMT (IMT-CC) was negatively associated with estradiol levels (β=-0.237, p=0.018) and positively with age (β=0.210, p=0.033), and BMI (β=0.260, p=0.010). However, correlations with estradiol and age did not remain significant when adjusted for systolic blood pressure and LDL-cholesterol levels. A high prevalence of subclinical atherosclerosis was detected in this sample of postmenopausal women with low/medium CV risk by the FRS. The association between IMT-CC and age or endogenous estrogen levels was dependent of blood pressure and LDL-cholesterol in these postmenopausal women from Southern Brazil. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  14. Chemical constituents and antioxidant activity of the Arctic mushroom Lycoperdon molle Pers

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    Purnima Singh

    2012-03-01

    Full Text Available The biochemical adaptations of fungi to the harsh conditions of the Arctic may mean that these organisms have properties useful to people. Using samples of the puffball mushroom Lycoperdon molle Pers. (Basidiomycota, Fungi collected at Ny-Ålesund, Svalbard, we examined the in vitro antioxidant potential of this species by investigating its free-radical scavenging (FRS activity, inhibition of lipid peroxidation (ILP and Trolox equivalent antioxidant capacity (TEAC. The FRS activity of the samples in various organic solvents, including methanol, ethanol, acetone and dimethyl sulfoxide (DMSO, were found to be in the range of 44.00–89.60%, while ILP activities ranged from 32.00 to 54.41%. The methanol extract showed the highest levels of FRS (89.60% and ILP (54.41% compared to standard antioxidants butylated hydroxyanisol and butylated hydroxytoluene (BHT. The TEAC value was also found to be higher compared to the standard water soluble vitamin E analogue Trolox (3.9 mM. Antimicrobial screening of Lycoperdon molle extracts was negative to the tested microorganisms. Using electrospray ionization mass spectrometry (ESI-MS, we determined that the samples contained compounds such as phosphoethanolamine, monomethyl arsenic acid, phosphatidyl glycerol, phosphoionositol, phosphoserine and lysophosphatidyl choline. We found that Lycoperdon molle showed strong antioxidant abilities compared to the standards, suggesting that this and perhaps other Arctic mushrooms could be valuable sources of natural antioxidants for the pharmaceutical industry. To our knowledge, this is the first report of the antioxidant activity in any Arctic mushroom.

  15. Effect of rosuvastatin on progression of carotid intima-media thickness in low-risk individuals with subclinical atherosclerosis: the METEOR Trial.

    Science.gov (United States)

    Crouse, John R; Raichlen, Joel S; Riley, Ward A; Evans, Gregory W; Palmer, Mike K; O'Leary, Daniel H; Grobbee, Diederick E; Bots, Michiel L

    2007-03-28

    Atherosclerosis is often advanced before symptoms appear and it is not clear whether treatment is beneficial in middle-aged individuals with a low Framingham risk score (FRS) and mild to moderate subclinical atherosclerosis. To assess whether statin therapy could slow progression and/or cause regression of carotid intima-media thickness (CIMT) over 2 years. Randomized, double-blind, placebo-controlled study (Measuring Effects on Intima-Media Thickness: an Evaluation of Rosuvastatin [METEOR]) of 984 individuals, with either age (mean, 57 years) as the only coronary heart disease risk factor or a 10-year FRS of less than 10%, modest CIMT thickening (1.2-cholesterol (mean, 154 mg/dL); conducted at 61 primary care centers in the United States and Europe between August 2002 and May 2006. Participants received either a 40-mg dose of rosuvastatin or placebo. Rate of change in maximum CIMT (assessed with B-mode ultrasound) for 12 carotid sites; changes in maximum CIMT of the common carotid artery, carotid bulb, and internal carotid artery sites and in mean CIMT of the common carotid artery sites. CIMT regression was assessed in the rosuvastatin group only. Among participants in the rosuvastatin group, the mean (SD) baseline LDL cholesterol level of 155 (24.1) mg/dL declined to 78 (27.5) mg/dL, a mean reduction of 49% (Padults with an FRS of less than 10% and evidence of subclinical atherosclerosis, rosuvastatin resulted in statistically significant reductions in the rate of progression of maximum CIMT over 2 years vs placebo. Rosuvastatin did not induce disease regression. Larger, longer-term trials are needed to determine the clinical implications of these findings. clinicaltrials.gov Identifier: NCT00225589

  16. A novel approach to cardiovascular health by optimizing risk management (ANCHOR): behavioural modification in primary care effectively reduces global risk.

    Science.gov (United States)

    Cox, Jafna L; Vallis, T Michael; Pfammatter, Angela; Szpilfogel, Claudine; Carr, Brendan; O'Neill, Blair J

    2013-11-01

    Primary care is well positioned to facilitate cardiovascular risk improvement and reduce future cardiovascular disease (CVD) burden. The efficacy of risk factor screening, behavioural counselling, and pharmacological treatment to lower CVD risk was assessed via a prospective pre- and postintervention health risk assessment, individualized intervention with behaviour modification, risk factor treatment, and linkage to community programs, with 1-year follow-up and final health risk assessment. Primary outcome was the proportion of subjects with moderate and high baseline Framingham Risk Score (FRS) reducing their risk by 10% and 25%, respectively; the secondary end point was the proportion dropping ≥ 1 risk category. Patients were enrolled (N = 1509) from March 2006 through October 2008 and 72% completed the study. This analysis focuses on 563 subjects with moderate or high baseline FRS, and excluded 325 low-risk patients and 205 with established CVD or diabetes mellitus. Median age was 56 years, 57.7% were female. The primary outcome was achieved in 31.8% (N = 112; 95% confidence interval [CI], 26.9%-36.6%) of moderate risk FRS participants and 47.9% (N = 101; 95% CI, 41.2%-54.6%) of high-risk participants. The secondary outcome was achieved by 37.2% (N = 210; 95% CI, 33.2%-41.2%). Prevalence of metabolic syndrome fell from 79.2% (N = 446; 95% CI, 75.9%-82.6%) at entry to 52.8% (N = 303; 95% CI, 48.7%-56.9%) at study end. Significant improvements in all modifiable risk factors occurred through lifestyle modification. Global cardiovascular risk can be effectively decreased via lifestyle changes informed by readiness to change assessment and individualized counselling targeting specific behaviours. ClinicalTrials.gov number NCT01620996. Copyright © 2013 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.

  17. 3D‐Facial Expression Synthesis and its Application to Face Recognition Systems

    Directory of Open Access Journals (Sweden)

    Rogelio Hasimoto‐Beltran

    2009-08-01

    Full Text Available One of the main problems in Face Recognition systems is the recognition of an input face with a different expression than theavailable in the training database. In this work, we propose a new 3D‐face expression synthesis approach for expressionindependent face recognition systems (FRS. Different than current schemes in the literature, all the steps involved in ourapproach (face denoising, registration, and expression synthesis are performed in the 3D domain. Our final goal is to increasethe flexibility of 3D‐FRS by allowing them to artificially generate multiple face expressions from a neutral expression face. Ageneric 3D‐range image is modeled by the Finite Element Method with three simplified layers representing the skin, fatty tissueand the cranium. The face muscular anatomy is superimposed to the 3D model for the synthesis of expressions. Our approachcan be divided into three main steps: Denoising Algorithm, which is applied to remove long peaks present in the original 3Dfacesamples; Automatic Control Points Detection, to detect particular facial landmarks such as eye and mouth corners, nosetip, etc., helpful in the recognition process; Face Registration of a 3D‐face model with each sample face with neutral expressionin the training database in order to augment its training set (with 18 predefined expressions. Additional expressions can belearned from input faces or an unknown expression can be transformed to the closest known expression. Our results show thatthe 3D‐face model resembles perfectly the neutral expression faces in the training database while providing a natural change ofexpression. Moreover, the inclusion of our expression synthesis approach in a simple 3D‐FRS based on Fisherfaces increasedsignificantly the recognition rate without requiring complex 3D‐face recognition schemes.

  18. The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective study

    Directory of Open Access Journals (Sweden)

    Tracy Russell P

    2011-03-01

    Full Text Available Abstract Background Genetic risk factors might improve prediction of coronary events. Several variants at chromosome 9p21.3 have been widely reported to be associated with coronary heart disease (CHD in prospective and case-control studies. A variant of KIF6 (719Arg has also been reported to be associated with increased risk of CHD in large prospective studies, but not in case-control studies. We asked whether the addition of genetic information (the 9p21.3 or KIF6 variants or a well-established non-genetic risk factor (C-reactive protein [CRP] can improve risk prediction by the Framingham Risk Score (FRS in the Cardiovascular Health Study (CHS--a prospective observational study of risk factors for cardiovascular disease among > 5,000 participants aged 65 or older. Methods Improvement of risk prediction was assessed by change in the area under the receiver-operator characteristic curve (AUC and by net reclassification improvement (NRI. Results Among white participants the FRS was improved by addition of KIF6 719Arg carrier status among men as assessed by the AUC (from 0.581 to 0.596, P = 0.03 but not by NRI (NRI = 0.027, P = 0.32. Adding both CRP and 719Arg carrier status to the FRS improved risk prediction by the AUC (0.608, P = 0.02 and NRI (0.093, P = 0.008 in men, but not women (P ≥ 0.24. Conclusions While none of these risk markers individually or in combination improved risk prediction among women, a combination of KIF6 719Arg carrier status and CRP levels modestly improved risk prediction among white men; although this improvement is not significant after multiple-testing correction. These observations should be investigated in other prospective studies.

  19. Screening for halogenated flame retardants in European consumer products, building materials and wastes.

    Science.gov (United States)

    Vojta, Šimon; Bečanová, Jitka; Melymuk, Lisa; Komprdová, Klára; Kohoutek, Jiří; Kukučka, Petr; Klánová, Jana

    2017-02-01

    To fulfill national and international fire safety standards, flame retardants (FRs) are being added to a wide range of consumer products and building materials consisting of flammable materials like plastic, wood and textiles. While the FR composition of some products and materials has been identified in recent years, the limited global coverage of the data and the large diversity in consumer products necessitates more information for an overall picture of the FR composition in common products/materials. To address this issue, 137 individual samples of various consumer products, building materials and wastes were collected. To identify and characterize potential sources of FRs in indoor environment, all samples were analyzed for content of polybrominated diphenyl ethers (PBDEs), hexabromocyclododecanes (HBCDDs) and novel flame retardants (NFRs). The most frequently detected were HBCDDs (85%), with the highest median concentration of Σ4HBCDDs of 300 mg kg-1 in polystyrenes. The highest median concentration of Σ10PBDEs was found in recycled plastic materials, reaching 4 mg kg-1. The lowest concentrations were observed for NFRs, where the median of Σ12NFRs reached 0.4 mg kg-1 in the group of electrical & electronic equipment wastes. This suggests that for consumer products and building materials that are currently in-use, legacy compounds still contribute to the overall burden of FRs. Additionally, contrasting patterns of FR composition in recycled and virgin plastics, revealed using principle component analysis (PCA), suggest that legacy flame retardants are reentering the market through recycled products, perpetuating the potential for emissions to indoor environments and thus for human exposure. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Organophosphorus flame retardants – Toxicity and influence on human health

    Directory of Open Access Journals (Sweden)

    Elżbieta Bruchajzer

    2015-06-01

    Full Text Available Organophosphorus flame retardants (flame retardants, FRs have been used for several decades in many industries, including the production of dyes, varnishes, adhesives, synthetic resins, polyvinyl chloride, hydraulic fluids, plastics and textiles. Their importance in recent times has increased due to i.a., significantly reduced use of polybrominated diphenyl ethers (PBDEs – persistent organic pollutants, dangerous for the environment. The aim of this study was to review the available literature data concerning phosphorous FRs primarily for neurotoxic, fertility, reproductive and carcinogenic effects. The analysis concerned the following most commonly used substances: tris(2-ethylhexylphosphate (TEHP, tris(2-butoxyethylphosphate (TBEP, triphenyl phosphate (TPP, tris(2-chloroethylphosphate (TCEP, tetrakis(hydroxymethyl-phosphonium chloride (THPC, tributyl phosphate (TBP, tricresyl phosphate (TCP, tris(2-chloroisopropylphosphate (TCPP, tris(1,3-dichloroisopropylphosphate (TDCP and tetrakis(hydroxymethyl phosphonium sulphate (THPS. In animal studies neurotoxic effects were found after exposure to TBEP, THPC, TBP and TCP, while in humans they were observed only after exposure to TCP. TCEP, THPS, TBP, TCP and TDCP caused disorders in fertility and/or fetal development of animals. Adverse effects on reproduction in humans may be caused by TPP, TCP, and TDCP. In laboratory animals the development of tumors was observed after high doses of TEHP, TCEP, TBP and TDCP. None of these compounds is classified as a human carcinogen. The environmental toxicity of phosphate FRs is low (except for TPP, TCEP and TBEP. They are not stable compounds, in living organisms they are metabolised and quickly excreted. Therefore, they can be used as an alternative to PBDEs. Med. Pr. 2015;66(2:235–264

  1. Smart radio: spectrum access for first responders

    Science.gov (United States)

    Silvius, Mark D.; Ge, Feng; Young, Alex; MacKenzie, Allen B.; Bostian, Charles W.

    2008-04-01

    This paper details the Wireless at Virginia Tech Center for Wireless Telecommunications' (CWT) design and implementation of its Smart Radio (SR) communication platform. The CWT SR can identify available spectrum within a pre-defined band, rendezvous with an intended receiver, and transmit voice and data using a selected quality of service (QoS). This system builds upon previous cognitive technologies developed by CWT for the public safety community, with the goal of providing a prototype mobile communications package for military and public safety First Responders. A master control (MC) enables spectrum awareness by characterizing the radio environment with a power spectrum sensor and an innovative signal detection and classification module. The MC also enables spectrum and signal memory by storing sensor results in a knowledge database. By utilizing a family radio service (FRS) waveform database, the CWT SR can create a new communication link on any designated FRS channel frequency using FM, BPSK, QPSK, or 8PSK modulations. With FM, it supports analog voice communications with legacy hand-held FRS radios. With digital modulations, it supports IP data services, including a CWT developed CVSD-based VoIP protocol. The CWT SR coordinates spectrum sharing between analog primary users and digital secondary users by applying a simple but effective channel-change protocol. It also demonstrates a novel rendezvous protocol to facilitate the detection and initialization of communications links with neighboring SR nodes through the transmission of frequency-hopped rendezvous beacons. By leveraging the GNU Radio toolkit, writing key modules entirely in Python, and utilizing the USRP hardware front-end, the CWT SR provides a dynamic spectrum test bed for future smart and cognitive radio research.

  2. Development of a new diabetes risk prediction tool for incident coronary heart disease events: the Multi-Ethnic Study of Atherosclerosis and the Heinz Nixdorf Recall Study.

    Science.gov (United States)

    Yeboah, Joseph; Erbel, Raimund; Delaney, Joseph Chris; Nance, Robin; Guo, Mengye; Bertoni, Alain G; Budoff, Matthew; Moebus, Susanne; Jöckel, Karl-Heinz; Burke, Gregory L; Wong, Nathan D; Lehmann, Nils; Herrington, David M; Möhlenkamp, Stefan; Greenland, Philip

    2014-10-01

    We develop a new diabetes CHD risk estimator using traditional risk factors plus coronary artery calcium (CAC), ankle-brachial index (ABI), high sensitivity C-reactive protein, family history of CHD, and carotid intima-media thickness and compared it with United Kingdom Prospective Diabetes study (UKPDS), Framingham risk and the NCEP/ATP III risk scores in type 2 diabetes mellitus (T2DM). We combined data from T2DM without clinical CVD in the Multi-Ethnic Study of Atherosclerosis (MESA) and the Heinz Nixdorf Recall Study (N = 1343). After a mean follow-up of 8.5 years, 85 (6.3%) participants had incident CHD. Among the novel risk markers, CAC best predicted CHD independent of the FRS [hazard ratio: HR (95% CI): log (CAC +25):1.69 (1.45-1.97), p 25 and ≤125:2.29 (0.87-5.95), >125 and ≤400: 3.87 (1.57-9.57), >400: 5.97 (2.57-13.84), respectively). The MESA-HNR diabetes CHD risk score has better accuracy for the main outcome versus the FRS or UKPDS [area under curve (AUC) of 0.76 vs. 0.70 and 0.69, respectively; all p III guidelines, the MESA-HNR score has an NRI of 0.74 for the main outcome. This new CHD risk estimator has better discriminative ability for incident CHD than the FRS, UKPDS, and the ATP III/NCEP recommendations in a multi-ethnic cohort with T2DM. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  3. Evaluation of changes in serum chemistry in association with feed withdrawal or high dose oral gavage with dextran sodium sulfate- (DSS-) induced gut leakage in broiler chickens.

    Science.gov (United States)

    Kuttappan, V A; Vicuña, E A; Faulkner, O B; Huff, G R; Freeman, K A; Latorre, J D; Menconi, A; Tellez, G I; Hargis, B M; Bielke, L R

    2016-11-01

    Dextran sodium sulfate ( DSS: ) has been shown to be effective at inducing enteric inflammation in broiler chickens, resulting in increased leakage of orally administered fluorescein isothiocyanate dextran to circulation. In a previous study, 2 doses of DSS (0.45 g/dose) administered as oral gavage resulted in increased mucosal permeability. The main objective of the present study was to compare serum turbidity in control and DSS treated birds plus with feed restriction ( FR: ), and evaluate the associated serum chemistry. Three independent experiments were conducted with different combinations of treatment groups. In Experiment 1, control full-fed ( CON: ) and DSS full-fed ( FFD: ) with n = 15 birds/group were evaluated, Experiment 2 had groups (n = 15/group) CON, FFD, feed restriction ( FRS: for 34 h), and DSS with feed restriction ( FRD: ), and Experiment 3 (n = 15/group) had CON, FFD, and FRS (29 h FRS). All DSS treated birds received one or 2 doses of DSS by oral gavage (0.45 g/dose/bird). Results showed that, compared to CON group, there was an increase (P  0.05). Administration of DSS did not result in increase of serum enzymes such as alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase ( LDH: ), nonetheless, the FFD showed lower (P < 0.05) LDH level compared to CON in Experiment 2. Among the various serum chemistry parameters evaluated triglycerides had the highest positive correlation (r2 = 0.85; P < 0.05) with serum turbidity. DSS administration resulted in decreased serum protein levels, especially albumin. These results suggest that oral gavage with DSS in broiler chicks could result in changes to serum chemistry parameters which could be developed as potential marker/s for gut leakage. © 2016 Poultry Science Association Inc.

  4. Machine learning for prediction of all-cause mortality in patients with suspected coronary artery disease: a 5-year multicentre prospective registry analysis.

    Science.gov (United States)

    Motwani, Manish; Dey, Damini; Berman, Daniel S; Germano, Guido; Achenbach, Stephan; Al-Mallah, Mouaz H; Andreini, Daniele; Budoff, Matthew J; Cademartiri, Filippo; Callister, Tracy Q; Chang, Hyuk-Jae; Chinnaiyan, Kavitha; Chow, Benjamin J W; Cury, Ricardo C; Delago, Augustin; Gomez, Millie; Gransar, Heidi; Hadamitzky, Martin; Hausleiter, Joerg; Hindoyan, Niree; Feuchtner, Gudrun; Kaufmann, Philipp A; Kim, Yong-Jin; Leipsic, Jonathon; Lin, Fay Y; Maffei, Erica; Marques, Hugo; Pontone, Gianluca; Raff, Gilbert; Rubinshtein, Ronen; Shaw, Leslee J; Stehli, Julia; Villines, Todd C; Dunning, Allison; Min, James K; Slomka, Piotr J

    2017-02-14

    Traditional prognostic risk assessment in patients undergoing non-invasive imaging is based upon a limited selection of clinical and imaging findings. Machine learning (ML) can consider a greater number and complexity of variables. Therefore, we investigated the feasibility and accuracy of ML to predict 5-year all-cause mortality (ACM) in patients undergoing coronary computed tomographic angiography (CCTA), and compared the performance to existing clinical or CCTA metrics. The analysis included 10 030 patients with suspected coronary artery disease and 5-year follow-up from the COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter registry. All patients underwent CCTA as their standard of care. Twenty-five clinical and 44 CCTA parameters were evaluated, including segment stenosis score (SSS), segment involvement score (SIS), modified Duke index (DI), number of segments with non-calcified, mixed or calcified plaques, age, sex, gender, standard cardiovascular risk factors, and Framingham risk score (FRS). Machine learning involved automated feature selection by information gain ranking, model building with a boosted ensemble algorithm, and 10-fold stratified cross-validation. Seven hundred and forty-five patients died during 5-year follow-up. Machine learning exhibited a higher area-under-curve compared with the FRS or CCTA severity scores alone (SSS, SIS, DI) for predicting all-cause mortality (ML: 0.79 vs. FRS: 0.61, SSS: 0.64, SIS: 0.64, DI: 0.62; PMachine learning combining clinical and CCTA data was found to predict 5-year ACM significantly better than existing clinical or CCTA metrics alone.

  5. Morphology, spatial distribution, and concentration of flame retardants in consumer products and environmental dusts using scanning electron microscopy and Raman micro-spectroscopy.

    Science.gov (United States)

    Wagner, Jeff; Ghosal, Sutapa; Whitehead, Todd; Metayer, Catherine

    2013-09-01

    We characterized flame retardant (FR) morphologies and spatial distributions in 7 consumer products and 7 environmental dusts to determine their implications for transfer mechanisms, human exposure, and the reproducibility of gas chromatography-mass spectrometry (GC-MS) dust measurements. We characterized individual particles using scanning electron microscopy/energy dispersive x-ray spectroscopy (SEM/EDS) and Raman micro-spectroscopy (RMS). Samples were screened for the presence of 3 FR constituents (bromine, phosphorous, non-salt chlorine) and 2 metal synergists (antimony and bismuth). Subsequent analyses of select samples by RMS enabled molecular identification of the FR compounds and matrix materials. The consumer products and dust samples possessed FR elemental weight percents of up to 36% and 31%, respectively. We identified 24 FR-containing particles in the dust samples and classified them into 9 types based on morphology and composition. We observed a broad range of morphologies for these FR-containing particles, suggesting FR transfer to dust via multiple mechanisms. We developed an equation to describe the heterogeneity of FR-containing particles in environmental dust samples. The number of individual FR-containing particles expected in a 1-mg dust sample with a FR concentration of 100ppm ranged from 1000 particles. The presence of rare, high-concentration bromine particles was correlated with decabromodiphenyl ether concentrations obtained via GC-MS. When FRs are distributed heterogeneously in highly concentrated dust particles, human exposure to FRs may be characterized by high transient exposures interspersed by periods of low exposure, and GC-MS FR concentrations may exhibit large variability in replicate subsamples. Current limitations of this SEM/EDS technique include potential false negatives for volatile and chlorinated FRs and greater quantitation uncertainty for brominated FR in aluminum-rich matrices. Copyright © 2013 Elsevier Ltd. All rights

  6. Survival, Fertilization and Developmental Rates of Cryotop-Vitrified Oocyte and Embryo Using Low Concentrated Cryoprotectants

    Directory of Open Access Journals (Sweden)

    A Roozbehi

    2012-10-01

    Full Text Available Background & Aim: The preserving embryos, the risk of multiple pregnancies, the existence of factors in stimulated uterine cycle, are important forces in perfecting embryo cryopreservation. The aim of current study was to assess Survival, Fertilization and Developmental Rates (SRs, FRs, DRs of the mouse oocytes and embryos using cryotop and low concentrated cryoprotectants solutions. Methods: Mouse C57BL/6 oocytes and embryos were collected. Oocytes SRs, FRs, DRs were recorded after cryotop-vitrification/ warming. As well as comparing fresh oocytes and embryos, the data obtained from experimental groups (exp. applying 1.25, 1.0, and 0.75 Molar (M CPAs were analyzed in comparison to those of exp. adopting 1.5 M CPAs (largely-used concentration of EthylenGlycol (EG and Dimethylsulphoxide (DMSO. Results: The data of oocytes exposed to 1.25 M CPAs were in consistency with those exposed to 1.5 M and control group in terms of SR, FR and DR. As fewer concentrations were applied, the more decreased SRs, FRs and DRs were obtained from other experimental groups. The results of embryos were exposed to 1.25 M and 1.0 M was close to those vitrified with 1.5 M and fresh embryos. The results of 0.75 M concentrated CPAs solutions were significantly lower than those of control, 1.5 M and 1.0 M treated groups. Conclusion: CPAs limited reduction to 1.25 M and 1.0 M instead of using 1.5 M, for oocyte and embryo cryotop-vitrification procedure may be a slight adjustment.

  7. A novel abbreviation standard for organobromine, organochlorine and organophosphorus flame retardants and some characteristics of the chemicals.

    Science.gov (United States)

    Bergman, Ake; Rydén, Andreas; Law, Robin J; de Boer, Jacob; Covaci, Adrian; Alaee, Mehran; Birnbaum, Linda; Petreas, Myrto; Rose, Martin; Sakai, Shinichi; Van den Eede, Nele; van der Veen, Ike

    2012-11-15

    Ever since the interest in organic environmental contaminants first emerged 50years ago, there has been a need to present discussion of such chemicals and their transformation products using simple abbreviations so as to avoid the repetitive use of long chemical names. As the number of chemicals of concern has increased, the number of abbreviations has also increased dramatically, sometimes resulting in the use of different abbreviations for the same chemical. In this article, we propose abbreviations for flame retardants (FRs) substituted with bromine or chlorine atoms or including a functional group containing phosphorus, i.e. BFRs, CFRs and PFRs, respectively. Due to the large number of halogenated and organophosphorus FRs, it has become increasingly important to develop a strategy for abbreviating the chemical names of FRs. In this paper, a two step procedure is proposed for deriving practical abbreviations (PRABs) for the chemicals discussed. In the first step, structural abbreviations (STABs) are developed using specific STAB criteria based on the FR structure. However, since several of the derived STABs are complicated and long, we propose instead the use of PRABs. These are, commonly, an extract of the most essential part of the STAB, while also considering abbreviations previously used in the literature. We indicate how these can be used to develop an abbreviation that can be generally accepted by scientists and other professionals involved in FR related work. Tables with PRABs and STABs for BFRs, CFRs and PFRs are presented, including CAS (Chemical Abstract Service) numbers, notes of abbreviations that have been used previously, CA (Chemical Abstract) name, common names and trade names, as well as some fundamental physico-chemical constants. Copyright © 2012 Elsevier Ltd. All rights reserved.

  8. Validity of cardiovascular risk prediction models in Latin America and among Hispanics in the United States of America: a systematic review.

    Science.gov (United States)

    Cortes-Bergoderi, Mery; Thomas, Randal J; Albuquerque, Felipe N; Batsis, John A; Burdiat, Gerard; Perez-Terzic, Carmen; Trejo-Gutierrez, Jorge; Lopez-Jimenez, Francisco

    2012-08-01

    To assess the use and validity of prediction models to estimate the risk of cardiovascular disease (CVD) in Latin America and among Hispanic populations in the United States of America. This was a systematic review of three databases: Ovid MEDLINE (1 January 1950-15 April 2010), LILACS (1 January 1988-15 April 2010), and EMBASE (1 January 1988-15 April 2010). MeSH search terms and domains were related to CVD, prediction rules, Latin America (including the Caribbean), and Hispanics in the United States. Database searches were supplemented by correspondence with experts in the field. A total of 1 655 abstracts were identified, of which five cohorts with a total of 13 142 subjects met inclusion criteria. A Mexican cohort showed that the predicted/observed event-rate ratio for coronary heart disease (CHD) according to the Framingham risk score (FRS) was 1.68 (95% CI, 1.26-2.11); incident myocardial infarction, 1.36 (95% CI, 0.90-1.83); and CHD death, 1.21 (95% CI, 0.43-2.00). In Ecuador, a prediction model for CVD and total deaths in hypertensive patients had an area under the curve (AUC) of 0.79 (95% CI, 0.72-0.86), while the World Health Organization method had an AUC of 0.74 (95% CI, 0.67-0.82). A study predicting mortality risk in people with Chagas' disease had an AUC of 0.81 (95% CI, 0.72-0.90). Among a United State s cohort that included Hispanics, FRS overestimated CVD risk for Hispanics with an AUC of 0.69. Another study in the United States that assessed FRS factors predicting CVD death among Mexican-Americans had an AUC of 0.78. The evidence regarding CVD risk prediction rules in Latin America or among Hispanics in the United States is modest at best. It is likely that the FRS overestimates CVD risk in Hispanics when not properly recalibrated.

  9. Mine Warfare History and Technology

    Science.gov (United States)

    1975-07-01

    off, it released a spring-driven plunger which struck a " fulminating charge," thus exploding the mine. The discovery of fulminate of mercury (Hg(0NC...2> had been reported to the Royal Society in 1800 by Edward Charles Howard, FRS (brother of the 12th Duke of Norfolk). The use of fulminate of mer...generally a mixture of the two ( fulminate and potassium chlorate) in a small tube impacted at the closed end, the open end being in contact with

  10. �Saruman� Apple Cultivar

    Directory of Open Access Journals (Sweden)

    Radu SESTRAS

    2010-06-01

    Full Text Available The apple cultivar Saruman was obtained at Fruit Research Station Cluj, Romania (FRS Cluj, and homologated in 2007. Saruman was released by hybridization between Cluj III-VI-5-26 selection (Parmain dOr, open pollinated and NJ 46. The trees are vigorous, spreading shape, and with medium crop yield. The fruits have large size, conic shape and mostly red (purple coloration; they have white flesh with a sweet, crisp, aromatic flavour and low acidity. Fruits become ripe in the last decade of August, first decade of September and the fruits are proper for dessert and well suited for cooking, applesauce, cider, pies.

  11. Deriving and Interpreting Ka(karimusubi in Premodern Japanese

    Directory of Open Access Journals (Sweden)

    Moreno MITROVIĆ

    2015-02-01

    Full Text Available This paper provides a new syntax and semantics for kakarimusubi (KM, a focus construction prominent in the grammar of Old Japanese (OJ and Early Middle (Classical Japanese (CJ, which diachronically developed into the interrogative construction in Modern Japanese (MdJ headed by the ka particle. Adopting Chierchia & Caponigro’s (2013 novel analysis of Free Relatives (FRs as embedded interrogatives, an FR-based analysis of KM is proposed so as to obtain a compositional semantic analysis of this focus construction as well as an account of the adnominal marking of the presuppositional musubi component of this grammatical construction.

  12. Isotopic Temperatures and Symmetry Energy in Spectator Fragmentation

    Science.gov (United States)

    de Napoli, M.; Sfienti, C.; Bianchin, S.; Le Fèvre, A.; Łukasik, J.; Trautmann, W.; Adrich, P.; Aumann, T.; Bacri, C. O.; Barczyk, T.; Bassini, R.; Boiano, C.; Botvina, A. S.; Boudard, A.; Brzychczyk, J.; Chbihi, A.; Cibor, J.; Czech, B.; Ducret, J.-E.; Emling, H.; Frankland, J.; Hellström, M.; Henzlova, D.; Kezzar, K.; Immé, G.; Iori, I.; Johansson, H.; Lafriakh, A.; Le Gentil, E.; Leifels, Y.; Lynch, W. G.; Lühning, J.; Lynen, U.; Majka, Z.; Mocko, M.; Müller, W. F. J.; Mykulyak, A.; Orth, H.; Otte, A. N.; Palit, R.; Pawłowski, P.; Pullia, A.; Raciti, G.; Rapisarda, E.; Sann, H.; Schwarz, C.; Simon, H.; Sümmerer, K.; Tsang, M. B.; Volant, C.; Wallace, M.; Weick, H.; Wiechula, J.; Wieloch, A.; Zwieglinski, B.

    2008-04-01

    The influence of the isotopic composition in the breakup of projectile spectators at relativists energies has been studied at the GSI laboratory with the ALADiN spectrometer. Besides a primary beam of 124Sn, also secondary beams of 124La and 107Sn produced at the FRS fragment separator have been used in order to extend the range of isotopic compositions. The breakup temperatures obtained from the double ratios of isotopic yields have been extracted and compared with the limiting-temperature expectation. Moreover, from isoscaling analysis an apparent symmetry-energy term of the EOS has been extracted.

  13. Adding multiple risk factors improves Framingham coronary heart disease risk scores

    Directory of Open Access Journals (Sweden)

    Hu G

    2014-09-01

    Full Text Available Guizhou Hu,1 Martin Root,2 Ashlee W Duncan1 1BioSignia, Inc., Durham, NC, USA; 2Department of Nutrition and Health Care Management, Appalachian State University, Boone, NC, USA Purpose: Since the introduction of the Framingham Risk Score (FRS, numerous versions of coronary heart disease (CHD prediction models have claimed improvement over the FRS. Tzoulaki et al challenged the validity of these claims by illustrating methodology deficiencies among the studies. However, the question remains: Is it possible to create a new CHD model that is better than FRS while overcoming the noted deficiencies? To address this, a new CHD prediction model was developed by integrating additional risk factors, using a novel modeling process. Methods: Using the National Health Nutritional Examination Survey III data set with CHD-specific mortality outcomes and the Atherosclerosis Risk in Communities data set with CHD incidence outcomes, two FRSs (FRSv1 from 1998 and FRSv2 from National Cholesterol Education Program Adult Treatment Panel III, along with an additional risk score in which the high density lipoprotein (HDL component of FRSv1 was ignored (FRSHDL, were compared with a new CHD model (NEW-CHD. This new model contains seven elements: the original Framingham equation, FRSv1, and six additional risk factors. Discrimination, calibration, and reclassification improvements all were assessed among models. Results: Discrimination was improved for NEW-CHD in both cohorts when compared with FRSv1 and FRSv2 (P<0.05 and was similar in magnitude to the improvement of FRSv1 over FRSHDL. NEW-CHD had a similar calibration to FRSv2 and was improved over FRSv1. Net reclassification for NEW-CHD was substantially improved over both FRSv1 and FRSv2, for both cohorts, and was similar in magnitude to the improvement of FRSv1 over FRSHDL. Conclusion: While overcoming several methodology deficiencies reported by earlier authors, the NEW-CHD model improved CHD risk assessment when

  14. Florence Nightingale (1820-1910) and Sir John Forbes (1787-1861): neighbours in Old Burlington Street, Westminster.

    Science.gov (United States)

    Agnew, Robin

    2015-05-01

    The year 2010 marks the centenary of the birth of Florence Nightingale and will, no doubt, be universally remembered. Her life and nursing career have recently been fully described by Bostridge. It is less well known that her neighbour from November 1856 was the distinguished Scottish physician Sir John Forbes MD Edin FRCP Lond FRS DCL Oxon. Although they never met, they exchanged copies of each other's books and shared a mutual respect. © The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  15. Spectroscopy of η′ Mesic Nuclei via Semi-Exclusive Measurement at FAIR

    Directory of Open Access Journals (Sweden)

    Fujioka Hiroyuki

    2014-03-01

    Full Text Available In order to investigate a possible mass reduction of an η′ meson at finite density, a series of missing-mass spectroscopy experiments of η′-nucleus bound states with the 12C(p,d reaction is planned at GSI and FAIR. A semi-exclusive measurement with the tagging of protons from η′ two-body absorption (η′NN → NN will be a key feature in an experiment with Super-FRS at FAIR.

  16. Dynamic IPPA studies; Techniques and applications

    Energy Technology Data Exchange (ETDEWEB)

    Schad, Nikolaus (Siena Univ. (Italy))

    1993-12-01

    Dynamic IPPA studies (1 fr/s) and sequential regional analysis of clearing and accumulation rates on image and histograms (ROI's) allow one to evaluate the local density of viable cells and potential of recovery by interventions. Use of high-count rate multicrystal gamma camera makes the study cost-effective since injection of 1 mCi of IPPA is sufficient for information. The technique has been proved adequate to evaluate the viability of the LAD-territory in patients with prior myocardial infarction, akinesia or dyskinesia of the anterior wall. (author).

  17. Comparison of 3 risk estimators to guide initiation of statin therapy for primary prevention of cardiovascular disease.

    Science.gov (United States)

    Ofori, Sandra; Dodiyi-Manuel, Sotonye; Akpa, Maclean R

    Among high-risk individuals, statins are beneficial for primary prevention of cardiovascular disease (CVD). In Nigeria, currently, there are no CVD prevention guidelines, so the use of CVD risk estimation to guide statin therapy is left to the discretion of the physician. The objective of the study was to compare 3 CVD risk estimation tools in the evaluation of patients presenting to a tertiary hospital in Nigeria. Cross-sectional study involving 295 patients with any CVD risk factors but not taking statins. Traditional CVD risk factors were assessed with a standard questionnaire and laboratory evaluation. Ten-year CVD risk was estimated with American College of Cardiology/American Heart Association Atherosclerotic Cardiovascular Disease (ACC/AHA ASCVD) Risk Estimator (2013), Framingham Risk Score (Framingham Risk Score [FRS] 2008), and the World Health Organisation/International Society of Hypertension (WHO/ISH) risk prediction chart for Africa Region D. Kappa statistic was used to determine agreement among the estimators. The mean age was 48.4 ± 10.4 years; 60.7% were females. Risk factors for CVD were hypertension (56.3%), dyslipidemia (41.4%), diabetes (20%), obesity (28.5%), and cigarette smoking (4.4%). In all, 50.2%, 16.9%, and 15.2% were classified as high risk using the ACC/AHA ASCVD Risk Estimator, FRS 2008, and WHO/ISH risk chart, respectively. The agreement was moderate between FRS and WHO/ISH (Kappa 0.414, P < .001) and fair between ACC/AHA Estimator and WHO/ISH (Kappa 0.223, P < .001) and between ACC/AHA Estimator and FRS (Kappa 0.301, P < .001). The considerable variation in prediction of high risk using the 3 tools may lead to underutilization of evidence-based therapy. This underscores the dire need for the development of risk prediction tools derived from our own Nigerian population. Copyright © 2017 National Lipid Association. Published by Elsevier Inc. All rights reserved.

  18. The SOFIA Experiment

    Science.gov (United States)

    Boutoux, G.; Bélier, G.; Chatillon, A.; Ebran, A.; Gorbinet, T.; Laurent, B.; Martin, J.-F.; Pellereau, E.; Taieb, J.; Audouin, L.; Tassan-Got, L.; Jurado, B.; Álvarez-Pol, H.; Ayyad, Y.; Benlliure, J.; Caamaño, M.; Cortina-Gil, D.; Fernández-Domínguez, B.; Paradela, C.; Rodriguez-Sanchez, J.-L.; Vargas, J.; Casarejos, E.; Heinz, A.; Kelić-Heil, A.; Kurz, N.; Nociforo, C.; Pietri, S.; Prochazka, A.; Rossi, D.; Schmidt, K.-H.; Simon, H.; Voss, B.; Weick, H.; Winfield, J. S.

    SOFIA (Study On FIssion with Aladin) is an innovative experimental programme on nuclear fission carried out at GSI. In August 2012, we used relativistic secondary beams of neutron-deficient actinides and pre-actinides provided by the FRS and studied their fission, induced by electromagnetic interaction, in inverse kinematics. This experiment will provide for the first time complete isotopic yields (nuclear charge and mass) for both fragments over a broad range of fissioning nuclei from 238Np down to 183Hg. In this article, we discuss the experimental set-up and present promising preliminary results.

  19. Excitation of Nucleon Resonances in Heavy-Ion Charge-Exchange Reactions

    Science.gov (United States)

    Benlliure, J.; Vargas, J.; Alvarez-Pol, H.; Aumann, T.; Atkinson, J.; Ayyad, Y.; Beceiro, S.; Borezky, K.; Chatillon, A.; Cortina, D.; Diaz, P.; Estrade, A.; Geissel, H.; Lenske, H.; Litvinov, Y.; Mostazo, M.; Paradela, C.; Pietri, S.; Prochazka, A.; Taieb, J.; Takechi, M.; Vidaña, I.; Weick, H.; Winfield, J.

    Isobaric charge-exchange reactions induced by different tin isotopes have been investigated at GSI. The high-resolving power of the FRS spectrometer made it possible to separate elastic and inelastic components in the missing-energy spectra of the ejectiles. The inelastic component was associated to the in-medium excitation of nucleon resonances such as the Delta and Roper resonances. These data are expected to contribute to better understand the role of subnuclear degrees of freedom in three body forces or the missing strength in Gamow-Teller transitions but also to investigate the abundance of protons and neutrons at the nuclear periphery.

  20. Isomeric decay spectroscopy of the Bi217 isotope

    Science.gov (United States)

    Gottardo, A.; Valiente-Dobón, J. J.; Benzoni, G.; Lunardi, S.; Gadea, A.; Algora, A.; Al-Dahan, N.; de Angelis, G.; Ayyad, Y.; Bazzacco, D.; Benlliure, J.; Boutachkov, P.; Bowry, M.; Bracco, A.; Bruce, A. M.; Bunce, M.; Camera, F.; Casarejos, E.; Cortes, M. L.; Crespi, F. C. L.; Corsi, A.; Denis Bacelar, A. M.; Deo, A. Y.; Domingo-Pardo, C.; Doncel, M.; Engert, T.; Eppinger, K.; Farrelly, G. F.; Farinon, F.; Farnea, E.; Geissel, H.; Gerl, J.; Goel, N.; Górska, M.; Grebosz, J.; Gregor, E.; Habermann, T.; Hoischen, R.; Janik, R.; John, P. R.; Klupp, S.; Kojouharov, I.; Kurz, N.; Lenzi, S. M.; Leoni, S.; Mandal, S.; Menegazzo, R.; Mengoni, D.; Million, B.; Modamio, V.; Morales, A. I.; Napoli, D. R.; Naqvi, F.; Nicolini, R.; Nociforo, C.; Pfützner, M.; Pietri, S.; Podolyák, Zs.; Prochazka, A.; Prokopowicz, W.; Recchia, F.; Regan, P. H.; Reed, M. W.; Rudolph, D.; Sahin, E.; Schaffner, H.; Sharma, A.; Sitar, B.; Siwal, D.; Steiger, K.; Strmen, P.; Swan, T. P. D.; Szarka, I.; Ur, C. A.; Walker, P. M.; Weick, H.; Wieland, O.; Wollersheim, H.-J.

    2014-09-01

    The structure of the neutron-rich bismuth isotope Bi217 has been studied for the first time. The fragmentation of a primary U238 beam at the FRS-RISING setup at GSI was exploited to perform γ-decay spectroscopy, since μs isomeric states were expected in this nucleus. Gamma rays following the decay of a t1/2=3 μs isomer were observed, allowing one to establish the low-lying structure of Bi217. The level energies and the reduced electric quadrupole transition probability B (E2) from the isomeric state are compared to large-scale shell-model calculations.