Benign metastasizing leiomyoma of the cervical spine 31 years after uterine leiomyoma resection.

Science.gov (United States)

Berti, Aldo F; Santillan, Alejandro; Velasquez, Luis A

2015-09-01

We report a 74-year-old woman presenting with a leiomyoma of the cervical spine 31 years after uterine leiomyoma resection. Benign metastasizing leiomyoma to the cervical spine is very rare. To the best of our knowledge, this is the fourth reported patient with a leiomyoma metastasizing to the cervical spine and that with the longest latency period for this type of tumor, 31 years. The pathological features were typical of leiomyoma. Copyright © 2015 Elsevier Ltd. All rights reserved.

Midlife cardiovascular fitness and dementia: A 44-year longitudinal population study in women.

Science.gov (United States)

Hörder, Helena; Johansson, Lena; Guo, XinXin; Grimby, Gunnar; Kern, Silke; Östling, Svante; Skoog, Ingmar

2018-04-10

To investigate whether greater cardiovascular fitness in midlife is associated with decreased dementia risk in women followed up for 44 years. A population-based sample of 1,462 women 38 to 60 years of age was examined in 1968. Of these, a systematic subsample comprising 191 women completed a stepwise-increased maximal ergometer cycling test to evaluate cardiovascular fitness. Subsequent examinations of dementia incidence were done in 1974, 1980, 1992, 2000, 2005, and 2009. Dementia was diagnosed according to DSM-III-R criteria on the basis of information from neuropsychiatric examinations, informant interviews, hospital records, and registry data up to 2012. Cox regressions were performed with adjustment for socioeconomic, lifestyle, and medical confounders. Compared with medium fitness, the adjusted hazard ratio for all-cause dementia during the 44-year follow-up was 0.12 (95% confidence interval [CI] 0.03-0.54) among those with high fitness and 1.41 (95% CI 0.72-2.79) among those with low fitness. High fitness delayed age at dementia onset by 9.5 years and time to dementia onset by 5 years compared to medium fitness. Among Swedish women, a high cardiovascular fitness in midlife was associated with a decreased risk of subsequent dementia. Promotion of a high cardiovascular fitness may be included in strategies to mitigate or prevent dementia. Findings are not causal, and future research needs to focus on whether improved fitness could have positive effects on dementia risk and when during the life course a high cardiovascular fitness is most important. Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

Mount St. Helens: Still erupting lessons 31 years later

Science.gov (United States)

Rhonda Mazza; Charlie Crisafulli; Fred Swanson

2011-01-01

The massive volcanic eruption of Mount St. Helens 31 years ago provided the perfect backdrop for studying the earliest stages of forest development. Immediately after the eruption, some areas of the blast area were devoid of life. On other parts of the volcanic landscape, many species survived, although their numbers were greatly reduced. Reassembly began at many...

The normal range of serum calcium and phosphorus in 20-69 years population of Bushehr Port

Directory of Open Access Journals (Sweden)

Iraj Nabipour

2003-09-01

Full Text Available Serum calcium and phosphorus levels are the important biochemical markers of bone in health and disease. The normal range of these bone biochemical markers belong to the populations with different racial and nutritional states. In order to determine normal range of these elements, fasting sera of 1463 (619 males and 749 females, 20-69 years old healthy subjects were evaluated using Selectra autoanalyser. The subjects had not disorder of bone and predisposing conditions for osteoporosis. The mean of serum calcium level was 9.26 mg/dl (CI: 95%, 9.22-9.31 mg/dl for females and 9.43-9.54 mg/dl for males. The mean of serum phosphorus level was 4.12 mg/dl (CI: 95%, 4.16-4.24 mg/dl for females and 3.97-4.07 for males. Therefore, calcium and phosphorus levels are in concordance to international standard normal range in Bushehr port.

10 CFR 503.31 - Lack of alternate fuel supply for the first 10 years of useful life.

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Lack of alternate fuel supply for the first 10 years of useful life. 503.31 Section 503.31 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS NEW FACILITIES Permanent Exemptions for New Facilities § 503.31 Lack of alternate fuel supply for the first 10 years of...

76 FR 26324 - Order Making Fiscal Year 2012 Annual Adjustments to Section 31 Fee Rates

Science.gov (United States)

2011-05-06

... of x. 3. Calculate the mean and standard deviation of the series {[Delta] 1 , [Delta] 2... 2012 Annual Adjustments to Section 31 Fee Rates I. Background Section 31 of the Securities Exchange Act... the fee rates under Sections 31(b) and (c) of the Exchange Act in fiscal years 2002 through 2011. II...

44 CFR 204.53 - Certifying costs and payments.

Science.gov (United States)

2010-10-01

....21 and U. S. Treasury 31 CFR part 205, Cash Management Improvement Act. ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Certifying costs and payments. 204.53 Section 204.53 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY...

A comparison of MR elastography and {sup 31}P MR spectroscopy with histological staging of liver fibrosis

Energy Technology Data Exchange (ETDEWEB)

Godfrey, Edmund M. [St James' Hospital, Leeds (United Kingdom); St James' Hospital, Department of Radiology, Leeds (United Kingdom); Patterson, Andrew J.; Priest, Andrew N.; Davies, Susan E.; Joubert, Ilse; Krishnan, Anant S.; Shaw, Ashley S.; Alexander, Graeme J.; Allison, Michael E.; Griffiths, William J.H.; Gimson, Alexander E.S. [Addenbrooke' s Hospital, Cambridge (United Kingdom); Griffin, Nyree [St Thomas' s Hospital, London (United Kingdom); Lomas, David J. [University of Cambridge, Department of Radiology, Cambridge (United Kingdom)

2012-12-15

Conventional imaging techniques are insensitive to liver fibrosis. This study assesses the diagnostic accuracy of MR elastography (MRE) stiffness values and the ratio of phosphomonoesters (PME)/phosphodiesters (PDE) measured using {sup 31}P spectroscopy against histological fibrosis staging. The local research ethics committee approved this prospective, blinded study. A total of 77 consecutive patients (55 male, aged 49 {+-} 11.5 years) with a clinical suspicion of liver fibrosis underwent an MR examination with a liver biopsy later the same day. Patients underwent MRE and {sup 31}P spectroscopy on a 1.5 T whole body system. The liver biopsies were staged using an Ishak score for chronic hepatitis or a modified NAS fibrosis score for fatty liver disease. MRE increased with and was positively associated with fibrosis stage (Spearman's rank = 0.622, P < 0.001). PME/PDE was not associated with fibrosis stage (Spearman's rank = -0.041, p = 0.741). Area under receiver operating curves for MRE stiffness values were high (range 0.75-0.97). The diagnostic utility of PME/PDE was no better than chance (range 0.44-0.58). MRE-estimated liver stiffness increases with fibrosis stage and is able to dichotomise fibrosis stage groupings. We did not find a relationship between {sup 31}P MR spectroscopy and fibrosis stage. circle Magnetic resonance elastography (MRE) and MR spectroscopy can both assess the liver. (orig.)

40 CFR 86.709-99 - In-use emission standards for 1999 and later model year light-duty trucks.

Science.gov (United States)

2010-07-01

... 4.4 0.7 0.08 Natural Gas 0-3750 0.25 3.4 0.4 0.08 Natural Gas 3751-5750 0.32 4.4 0.7 0.08 LPG 0-3750 0.25 3.4 0.4 0.08 LPG 3751-5750 0.32 4.4 0.7 0.08 1 The applicable useful life is 5 years or 50,000... Natural Gas 0-3750 0.31 4.2 0.6 0.10 Natural Gas 3751-5750 0.40 5.5 0.97 0.10 LPG 0-3750 0.80 0.31 4.2 0.6...

Use of the Internet for Sexual Health Among Sexually Experienced Persons Aged 16 to 44 Years: Evidence from a Nationally Representative Survey of the British Population

Science.gov (United States)

Estcourt, Claudia S; Johnson, Anne M; Sonnenberg, Pam; Wellings, Kaye; Mercer, Catherine H

2016-01-01

Background Those who go online regarding their sexual health are potential users of new Internet-based sexual health interventions. Understanding the size and characteristics of this population is important in informing intervention design and delivery. Objective We aimed to estimate the prevalence in Britain of recent use of the Internet for key sexual health reasons (for chlamydia testing, human immunodeficiency virus [HIV] testing, sexually transmitted infection [STI] treatment, condoms/contraceptives, and help/advice with one’s sex life) and to identify associated sociodemographic and behavioral factors. Methods Complex survey analysis of data from 8926 sexually experienced persons aged 16-44 years in a 2010-2012 probability survey of Britain’s resident population. Prevalence of recent (past year) use of Internet sources for key sexual health reasons was estimated. Factors associated with use of information/support websites were identified using logistic regression to calculate age-adjusted odds ratios (AORs). Results Recent Internet use for chlamydia/HIV testing or STI treatment (combined) was very low (men: 0.31%; women: 0.16%), whereas 2.35% of men and 0.51% of women reported obtaining condoms/contraceptives online. Additionally, 4.49% of men and 4.57% of women reported recent use of information/support websites for advice/help with their sex lives. Prevalence declined with age (men 16-24 years: 7.7%; 35-44 years: 1.84%, PInternet sexual health seeking. Conclusions A minority in Britain used the Internet for the sexual health reasons examined. Use of information/support websites was reported by those at greater STI risk, including younger people, indicating that demand for online STI services, and Internet-based sexual health interventions in general, may increase over time in this and subsequent cohorts. However, the impact on health inequalities needs addressing during design and evaluation of online sexual health interventions so that they maximize

Use of the Internet for Sexual Health Among Sexually Experienced Persons Aged 16 to 44 Years: Evidence from a Nationally Representative Survey of the British Population.

Science.gov (United States)

Aicken, Catherine R H; Estcourt, Claudia S; Johnson, Anne M; Sonnenberg, Pam; Wellings, Kaye; Mercer, Catherine H

2016-01-20

Those who go online regarding their sexual health are potential users of new Internet-based sexual health interventions. Understanding the size and characteristics of this population is important in informing intervention design and delivery. We aimed to estimate the prevalence in Britain of recent use of the Internet for key sexual health reasons (for chlamydia testing, human immunodeficiency virus [HIV] testing, sexually transmitted infection [STI] treatment, condoms/contraceptives, and help/advice with one's sex life) and to identify associated sociodemographic and behavioral factors. Complex survey analysis of data from 8926 sexually experienced persons aged 16-44 years in a 2010-2012 probability survey of Britain's resident population. Prevalence of recent (past year) use of Internet sources for key sexual health reasons was estimated. Factors associated with use of information/support websites were identified using logistic regression to calculate age-adjusted odds ratios (AORs). Recent Internet use for chlamydia/HIV testing or STI treatment (combined) was very low (men: 0.31%; women: 0.16%), whereas 2.35% of men and 0.51% of women reported obtaining condoms/contraceptives online. Additionally, 4.49% of men and 4.57% of women reported recent use of information/support websites for advice/help with their sex lives. Prevalence declined with age (men 16-24 years: 7.7%; 35-44 years: 1.84%, PInternet sexual health seeking. A minority in Britain used the Internet for the sexual health reasons examined. Use of information/support websites was reported by those at greater STI risk, including younger people, indicating that demand for online STI services, and Internet-based sexual health interventions in general, may increase over time in this and subsequent cohorts. However, the impact on health inequalities needs addressing during design and evaluation of online sexual health interventions so that they maximize public health benefit.

[A juvenile nasopharyngeal angiofibroma: our 10-year experience in a tertiary centre].

Science.gov (United States)

Şahin, Bayram; Çomoğlu, Şenol; Sönmez, Said; Polat, Beldan; Değer, Kemal

2016-01-01

This study aims to evaluate the demographic characteristics, tumor stage, surgical treatment and recurrence rate among patients operated with a juvenile nasopharyngeal angiofibroma. This retrospective study included 45 patients (44 males, 1 female; mean age 21 years, range 9 to 55 years) who underwent surgery at Istanbul University, Istanbul Medical Faculty, Department of Otorhinolaryngology clinic between March 2006 and July 2015. The patients were classified according to age, sex, presenting symptom, tumor stage, surgical procedure applied, preoperative embolization, perioperative blood transfusion, complications, and the presence of recurrence. The most common presenting symptoms were epistaxis (78%) and nasal obstruction (73%). Preoperative angiography was performed on all patients and embolization was applied in eligible patients (69%). Transnasal endoscopic approach in 31 patients, midfacial degloving in six patients, and lateral rhinotomy approach in three patients were applied. The overall recurrence rate was 31% (n=14). The most important factor in determining the risk of postoperative recurrence is the preoperative tumor stage. Preoperative embolization reduces the amount of perioperative bleeding. Endoscopic transnasal approach decreases the rate of complications and length of hospitalization.

Model calculation of neutron reaction data for 31P in the energy range from 0.1 to 20 MeV

International Nuclear Information System (INIS)

Li Jiangting; Ge Zhigang; Sun Xiuquan

2006-01-01

The neutron data calculation of 31 P in the energy range from 0.1 to 20 MeV was carried out. The neutron optical potential parameters for 31 P in energy range from O.1 to 20 MeV were obtained, based on the fitting of the available neutron experimental data with the code APOM94. The DWUCK4 code was used to investigate the cross section for neutron direct inelastic scattering. The re-evaluated neutron data is based on the available measured data by using the UNF code. The theoretical results reproduce the experimental data well, and the results were given in ENDF/B-6 format. (authors)

Report and accounts for the year ended 31 December 1993

International Nuclear Information System (INIS)

1994-01-01

The document contains the Annual Report and Accounts for British Gas, the United Kingdom gas utility, for the financial year ended 31st December 1992. Government policies have meant that there is more competition in the contract sector of the UK gas market. British Gas has responded with a major restructuring in the UK and many initiatives to increase business overseas in many parts of the world. These projects are documented briefly. (UK)

Model calculation of neutron reaction data for {sup 31}P in the energy range from 0.1 to 20 MeV

Energy Technology Data Exchange (ETDEWEB)

Jiangting, Li [Physics Department, Northwest Univ., Xi' an (China); Zhigang, Ge [China Nuclear Data Center, China Inst. of Atomic Energy, Beijing (China); Xiuquan, Sun [Engineering and Technology Department, Shenzhen University, Shenzhen (China)

2006-07-15

The neutron data calculation of {sup 31}P in the energy range from 0.1 to 20 MeV was carried out. The neutron optical potential parameters for {sup 31}P in energy range from O.1 to 20 MeV were obtained, based on the fitting of the available neutron experimental data with the code APOM94. The DWUCK4 code was used to investigate the cross section for neutron direct inelastic scattering. The re-evaluated neutron data is based on the available measured data by using the UNF code. The theoretical results reproduce the experimental data well, and the results were given in ENDF/B-6 format. (authors)

Ranging Behaviour of Commercial Free-Range Broiler Chickens 2: Individual Variation.

Science.gov (United States)

Taylor, Peta S; Hemsworth, Paul H; Groves, Peter J; Gebhardt-Henrich, Sabine G; Rault, Jean-Loup

2017-07-20

Little is known about broiler chicken ranging behaviour. Previous studies have monitored ranging behaviour at flock level but whether individual ranging behaviour varies within a flock is unknown. Using Radio Frequency Identification technology, we tracked 1200 individual ROSS 308 broiler chickens across four mixed sex flocks in two seasons on one commercial farm. Ranging behaviour was tracked from first day of range access (21 days of age) until 35 days of age in winter flocks and 44 days of age in summer flocks. We identified groups of chickens that differed in frequency of range visits: chickens that never accessed the range (13 to 67% of tagged chickens), low ranging chickens (15 to 44% of tagged chickens) that accounted for range visits and included chickens that used the range only once (6 to 12% of tagged chickens), and high ranging chickens (3 to 9% of tagged chickens) that accounted for 33 to 50% of all range visits. Males spent longer on the range than females in winter ( p ranging behaviour may help optimise ranging opportunities in free-range systems and is important to elucidate the potential welfare implications of ranging.

44 CFR 13.44 - Termination for convenience.

Science.gov (United States)

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Termination for convenience. 13.44 Section 13.44 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY... § 13.44 Termination for convenience. Except as provided in § 13.43 awards may be terminated in whole or...

Epidemiology of oral diseases in individuals between the ages of 35 and 44 years:an epidemiological scenario of the worker

Directory of Open Access Journals (Sweden)

Érica Silva Carvalho

2010-04-01

Full Text Available Objectives: To review epidemiological studies on oral diseases, specifically caries, periodontal disease and oral cancer, in the age group between 35 and 44 years. Methods: The strategy used to identify the articles was to search the PubMed database using the following key words: dental health surveys, epidemiology, caries, periodotitis, cancer, always with Boolean operator, and without limitation of language. The exclusion criteria were as follows: articles published over 10 years ago, articles that did not deal with adults from 35 to 44 years old and articles that did not cover the issue proposed. Results: On dental caries 7.071 articles were found, from which 6.992 articles were excluded, leaving 79. In the criteria complete articles, of the 19 articles selected, 8 were coherent with the objectives of the study. On periodontal disease, 1.554 articles were found and 872 articles were excluded. After evaluating the complete articles, 6 articles were selected. With regard to the subject oral cancer, 573 articles were found and 3 articles suited the study. Conclusion: It may be considered that caries disease increases with age and that dental loss prevails in DMFT in adults. In adults the prevalence of calculus and shallow pockets prevails and the need for dentures is higher in elderly people although it is significant in adults etween the ages of 35 and 44 years. There is a higher incidence of oral cancer in men with a synergism in alcoholic smokers. During the search in the database, it was observed that the number of researches is lower among adults.

Periodontal conditions in 35-44 and 65-74-year-old adults in Denmark

DEFF Research Database (Denmark)

Krustrup, Ulla; Petersen, Poul Erik

2006-01-01

OBJECTIVES: To assess the periodontal health status in the Danish adult population and to analyze how the level of periodontal health is associated with age, gender, urbanization, socio-economic factors, and dental visiting habits; furthermore, to compare the periodontal health status of Danish a...... is needed with further emphasis on preventive care, and public health programs should focus on risk factors shared by chronic diseases in order to improve the periodontal health of Danish adults.......OBJECTIVES: To assess the periodontal health status in the Danish adult population and to analyze how the level of periodontal health is associated with age, gender, urbanization, socio-economic factors, and dental visiting habits; furthermore, to compare the periodontal health status of Danish...... Organization Basic Methods Criteria. RESULTS: The clinical examination revealed a low prevalence of healthy periodontal conditions in both age groups: at age 35-44 years 7.7% and at age 65-74 years 2.4% had healthy periodontal conditions. A high proportion of the elderly had scores of severe periodontal health...

Tonopah Test Range Post-Closure Inspection Annual Report, Tonopah Test Range, Nevada, Calendar Year 2003

Energy Technology Data Exchange (ETDEWEB)

U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; Bechtel Nevada

2004-04-01

This post-closure inspection report provides documentation of the semiannual inspection activities, maintenance and repair activities, and conclusions and recommendations for calendar year 2003 for eight corrective action units located on the Tonopah Test Range, Nevada.

Fertility of men and women aged 15-44 years in the United States: National Survey of Family Growth, 2006-2010.

Science.gov (United States)

Martinez, Gladys; Daniels, Kimberly; Chandra, Anjani

2012-04-12

This report presents national estimates of the fertility of men and women aged 15-44 years in the United States in 2006-2010 based on the National Survey of Family Growth (NSFG). Data are compared with similar measures for 2002. Descriptive tables of numbers, percentages, and means are presented and discussed. Data were collected through in-person interviews of a nationally representative sample of the household population aged 15-44 years in the United States between July 2006 and June 2010. The 2006-2010 NSFG sample is comprised of 22,682 respondents including 10,403 men and 12,279 women. The overall response rate for the 2006-2010 NSFG was 77%, 75% for men and 78% for women. Many of the fertility measures among men and women aged 15-44 based on the 2006-2010 NSFG were generally similar to those reported based on the 2002 NSFG. The mean age at first child's birth for women was 23 and the mean age at first child's birth for men was 25. One-half of first births to women were in their 20s and two-thirds of first births were fathered by men who were in their 20s. On average, women aged 15-44 have 1.3 children as of the time of the interview. By age 40, 85% of women had had a birth, and 76% of men had fathered a child. In 2006-2010, 22% of first births to women occurred within cohabiting unions, up from 12% in 2002. These measures differed by Hispanic origin and race and other demographic characteristics.

Midlife muscle strength and human longevity up to age 100 years: a 44-year prospective study among a decedent cohort.

Science.gov (United States)

Rantanen, Taina; Masaki, Kamal; He, Qimei; Ross, G Webster; Willcox, Bradley J; White, Lon

2012-06-01

We studied prospectively the midlife handgrip strength, living habits, and parents' longevity as predictors of length of life up to becoming a centenarian. The participants were 2,239 men from the Honolulu Heart Program/Honolulu-Asia Aging Study who were born before the end of June 1909 and who took part in baseline physical assessment in 1965-1968, when they were 56-68 years old. Deaths were followed until the end of June 2009 for 44 years with complete ascertainment. Longevity was categorized as centenarian (≥100 years, n = 47), nonagenarian (90-99 years, n = 545), octogenarian (80-89 years, n = 847), and ≤79 years (n = 801, reference). The average survival after baseline was 20.8 years (SD = 9.62). Compared with people who died at the age of ≤79 years, centenarians belonged 2.5 times (odds ratio (OR) = 2.52, 95% confidence interval (CI) = 1.23-5.10) more often to the highest third of grip strength in midlife, were never smokers (OR = 5.75 95% CI = 3.06-10.80), had participated in physical activity outside work (OR = 1.13 per daily hour, 95% CI = 1.02-1.25), and had a long-lived mother (≥80 vs. ≤60 years, OR = 2.3, 95% CI = 1.06-5.01). Associations for nonagenarians and octogenarians were parallel, but weaker. Multivariate modeling showed that mother's longevity and offspring's grip strength operated through the same or overlapping pathway to longevity. High midlife grip strength and long-lived mother may indicate resilience to aging, which, combined with healthy lifestyle, increases the probability of extreme longevity.

Elastic and inelastic scattering of alpha particles from /sup 40,44/Ca over a broad range of energies and angles

International Nuclear Information System (INIS)

Delbar, T.; Gregoire, G.; Paic, G.; Ceuleneer, R.; Michel, F.; Vanderpoorten, R.; Budzanowski, A.; Dabrowski, H.; Freindl, L.; Grotowski, K.; Micek, S.; Planeta, R.; Strzalkowski, A.; Eberhard, K.A.

1978-01-01

Angular distributions for α particle elastic scattering by /sup 40,44/Ca and excitation of the 3.73 MeV 3 - collective state of 40 Ca were measured for incident energies ranging from 40 to 62 MeV. An extensive optical model analysis of these elastic scattering cross sections and other available data, using squared Woods-Saxon form factors, results in potentials with fixed geometry for both real and imaginary parts and depths with smooth energy behavior over a broad incident energy range. These results are discussed in the frame of the semi-classical approximation developed by Brink and Takigawa. The sensitiveness of the calculated elastic scattering cross sections to the real part of the potentials as a function of the projectile-target distance has been investigated by means of a notch test. Distorted-wave Born-approximtion calculations for the excitation of the 3.73 MeV 3 - state of 40 Ca are presented

44 CFR 334.3 - Background.

Science.gov (United States)

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Background. 334.3 Section 334.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND... take into account the need to mobilize the Nation's resources in response to a wide range of crisis or...

An attempt of application of short lived 44K activity induced in the 44Ca(n,p)44K reaction using 14 MeV neutrons for total body calcium assessment in human subject

International Nuclear Information System (INIS)

Haratym, Z.; Kempisty, T.; Mikolajewski, S.; Rurarz, E.

1999-01-01

The status of in vivo neutron activation analysis techniques for the measurement of total body calcium in human subject is reviewed. Relevant data on the nuclear characteristics of calcium isotopes during interaction with neutrons ranging from slow up to 14 MeV neutrons are presented. Physical aspects of the measurement of in vivo total body calcium (TBCa) using 44 K activity induced in the 44 Ca(n,p) 44 K(T 1/2 =22.3 min) reaction by 14 MeV neutrons are discussed. The measurement of delayed γ-ray emitted during decay of activities induced in enriched 44 Ca, nat Ca, phantom filled with water solution of natural calcium and skeletal arm are considered. Results of measurements on the phantom and skeletal arm indicate a possibility to measure the TBCa using the 44 K activity. (author)

47. Annual Report for the year ended March 31, 1998

International Nuclear Information System (INIS)

1998-01-01

The annual report of the Manitoba Hydro-Electric Board covers the financial and operational activities of Manitoba Hydro during the fiscal year ending March 31, 1998. During the year under review, Manitoba Hydro, a provincial Crown corporation, served 394,328 customers, generated 34 billion kWh of electricity, of which 19.1 billion kWh were supplied to Manitoba consumers, generated gross revenues of S 1.041 billion, and had a net income of $ 110.5 million. Power generation reached record levels for the fourth year in a row and net income reached record heights for the third consecutive year. Among operational highlights, fighting the Red River Valley 'flood of the century' in Manitoba and providing significant assistance to ice storm-beleaguered utilities in the north-central U.S. and eastern Canada during the January ice storm were highlighted. Another event was implementing the Northern Flood Agreement with the Norway House Cree Nation. Opening up of the Manitoba Hydro transmission system to other utilities as part of Manitoba Hydro becoming a full member of the Mid-Continent Area Power Pool (MAPP) was featured. The adoption by Manitoba Hydro (as a member of the Canadian Electricity Association) of the Environmental Commitment and Responsibility Program, as a sign of commitment to responsible environmental management was particularly noteworthy

The role of a new CD44st in increasing the invasion capability of the human breast cancer cell line MCF-7

International Nuclear Information System (INIS)

Fang, Xin Jian; Jiang, Hua; Zhao, Xv Peng; Jiang, Wei Mei

2011-01-01

CD44, a hyaluronan (HA) receptor, is a multistructural and multifunctional cell surface molecule involved in cell proliferation, cell differentiation, cell migration, angiogenesis, presentation of cytokines, chemokines and growth factors to the corresponding receptors, and docking of proteases at the cell membrane, as well as in signaling for cell survival. The CD44 gene contains 20 exons that are alternatively spliced, giving rise to many CD44 isoforms, perhaps including tumor-specific sequences. Reverse transcriptase polymerase chain reaction (RT-PCR) and Western blotting were used to detect CD44st mRNA and CD44 protein in sensitive MCF-7, Lovo, K562 and HL-60 cell lines as well as their parental counterparts, respectively. The full length cDNA encoding CD44st was obtained from the total RNA isolated from MCF-7/Adr cells by RT-PCR, and subcloned into the pMD19-T vector. The CD44st gene sequence and open reading frame were confirmed by restriction enzyme analysis and nucleotide sequencing, and then inserted into the eukaryotic expression vector pcDNA3.1. The pcDNA3.1-CD44st was transfected into MCF-7 cells using Lipofectamine. After transfection, the positive clones were obtained by G418 screening. The changes of the MMP-2 and MMP-9 genes and protein levels were detected by RT-PCR and gelatin zymography, respectively. The number of the cells penetrating through the artificial matrix membrane in each group (MCF-7, MCF-7+HA, MCF-7/neo, MCF-7/neo+HA, MCF-7/CD44st, MCF-7/CD44st+HA and MCF-7/CD44st+Anti-CD44+HA) was counted to compare the change of the invasion capability regulated by the CD44st. Erk and P-Erk were investigated by Western blotting to approach the molecular mechanisms of MMP-2 and MMP-9 expression regulated by the CD44st. Sensitive MCF-7, Lovo, K562 and HL-60 cells did not contain CD44st mRNA and CD44 protein. In contrast, the multidrug resistance MCF-7/Adr, Lovo/Adr, K562/Adr and HL-60/Adr cells expressed CD44st mRNA and CD44 protein. The CD44st m

75 FR 9964 - Order Making Fiscal Year 2010 Mid-Year Adjustment to the Fee Rates Applicable Under Sections 31(b...

Science.gov (United States)

2010-03-04

... of x. 3. Calculate the mean and standard deviation of the series {[Delta] 1 , [Delta] 2...(j)(2) of the Exchange Act requires the Commission to issue an order adjusting the fee rates under... Adjusted Rate Section 31(j)(4)(B) of the Exchange Act provides that a mid-year adjustment shall take effect...

Optimization of reaction conditions for the radiolabeling of DOTA and DOTA-peptide with (44m/44)Sc and experimental evidence of the feasibility of an in vivo PET generator.

Science.gov (United States)

Huclier-Markai, S; Kerdjoudj, R; Alliot, C; Bonraisin, A C; Michel, N; Haddad, F; Barbet, J

2014-05-01

Among the number of generator systems providing radionuclides with decay parameters promising for imaging and treatment applications, there is the (44)Ti (T1/2=60 years)/(44)Sc (T1/2=3.97 h) generator. This generator provides a longer-lived daughter for extended PET/CT measurements compared to the chemically similar system (68)Ge/(68)Ga. Scandium also exists as (47)Sc, a potential therapeutic radionuclide. It is possible to produce (44)Sc in a cyclotron using, for example, the (44)Ca (d, n) (44)Sc nuclear reaction. In that case, the isomeric state (44 m)Sc (T1/2=58.6h) is co-produced and may be used as an in vivo(44 m)Sc/(44)Sc generator. The aim of this study is to evaluate the feasibility of this in vivo(44 m)Sc/(44)Sc generator and to demonstrate that the daughter radionuclide stays inside the chelator after decay of the parent radionuclide. Indeed, the physico-chemical process occurring after the primary radioactive decay (EC, IT, Auger electron …) has prevented in many cases the use of in-vivo generator, because of the post-effect as described in the literature. The DOTA macrocyclic ligand forms stable complexes with many cations and has been shown to be the most suitable chelating moiety for scandium. Initially, the radiolabeling of DOTA and a DOTA-peptide (DOTATATE) with Sc was performed and optimized as a function of time, pH, metal-to-ligand ratio and temperature. Next, the physico-chemical processes that could occur after the decay (post-effect) were studied. (44 m)Sc(III)-labeled DOTA-peptide was quantitatively adsorbed on a solid phase matrix through a hydrophobic interaction. Elutions were then performed at regular time intervals using a DTPA solution at various concentrations. Finally, the radiolabelled complex stability was studied in serum. Radiolabeling yields ranged from 90% to 99% for metal-to-ligand ratio ranging from 1:10 to 1:500 for DOTA or DOTATATE respectively. The optimum physico-chemical parameters were pH=4-6, t=20 min, T=70°C. Then

RADIO SOURCES FROM A 31 GHz SKY SURVEY WITH THE SUNYAEV-ZEL'DOVICH ARRAY

International Nuclear Information System (INIS)

Muchovej, Stephen; Hawkins, David; Lamb, James; Woody, David; Leitch, Erik; Carlstrom, John E.; Culverhouse, Thomas; Greer, Chris; Hennessy, Ryan; Loh, Michael; Marrone, Daniel P.; Pryke, Clem; Sharp, Matthew; Joy, Marshall; Miller, Amber; Mroczkowski, Tony

2010-01-01

We present the first sample of 31 GHz selected sources to flux levels of 1 mJy. From late 2005 to mid-2007, the Sunyaev-Zel'dovich Array observed 7.7 deg 2 of the sky at 31 GHz to a median rms of 0.18 mJy beam -1 . We identify 209 sources at greater than 5σ significance in the 31 GHz maps, ranging in flux from 0.7 mJy to ∼200 mJy. Archival NVSS data at 1.4 GHz and observations at 5 GHz with the Very Large Array are used to characterize the sources. We determine the maximum-likelihood integrated source count to be N(>S) = (27.2 ± 2.5)deg -2 x (S mJy ) -1.18±0.12 over the flux range 0.7-15 mJy. This result is significantly higher than predictions based on 1.4 GHz selected samples, a discrepancy which can be explained by a small shift in the spectral index distribution for faint 1.4 GHz sources. From comparison with previous measurements of sources within the central arcminute of massive clusters, we derive an overdensity of 6.8 ± 4.4, relative to field sources.

U.S. Army Deployment Injury Surveillance Summary Calendar Year 2008. 1 January 2008 - 31 December 2008

Science.gov (United States)

2009-09-15

basketball (24 percent), weightlifting (19 percent), PT (18 percent), and football (14 percent). Injury Prevention Report No. 12-HF-0C7F-10, 1 Jan... INJURY PREVENTION REPORT NO. 12-HF-0C7F-10 U.S. ARMY DEPLOYMENT INJURY SURVEILLANCE SUMMARY CALENDAR YEAR 2008 1 JANUARY 2008–31...2008 – 31 December 2008 4. TITLE AND SUBTITLE U.S. Army Deployment Injury Surveillance Summary 2008 5a. CONTRACT NUMBER n/a 5b. GRANT NUMBER

[Trends of vegetables and fruits consumption among Chinese adults aged 18 to 44 years old from 1991 to 2011].

Science.gov (United States)

Xiao, Yingting; Su, Chang; Ouyang, Yifei; Zhang, Bing

2015-03-01

To identify the trends of vegetables and fruits consumption among Chinese adults aged 18 to 44 years old from 1991 to 2011. Twenty four hour dietary recall data from China Health and Nutrition Survey (1991, 1993, 1997, 2000, 2004, 2006, 2009 and 2011) were used to identify the trends of vegetables and fruits consumption among Chinese between 18 and 44 years old. From 1991 to 2011, the proportion of daily consumption of vegetables rarely varied, while the vegetables intake declined significantly; and the proportion of daily consumption and intake of fruits kept increasing as follows. By 2011, the proportion of daily consumption and intake of vegetables and fruits among the respondents were 99.7%, 48.0%, 321.6 g/d, and 90.1 g/d respectively. A significant drop was found in the vegetables intake among the respondents against the vegetables intake as recommended by the Chinese dietary guidelines, up to 50.2% in 2011; a significant rise was found in the fruits intake of the respondents against the fruits intake as recommended by the said guidelines, up to 17.4% in 2011. The average daily intake of vegetables and fruits of young and middle-aged residents (18-44 age group) in nine provinces in China was found lower than that recommended in the Chinese dietary guidelines; in view of the high proportion of people having less vegetables and fruits intake that those recommended by the Chinese dietary guidelines, further measures are expected to encourage their vegetables and fruits intake.

Health procrastination: The experience of 35-44 years old men

OpenAIRE

Silkane V.; Austers I.

2018-01-01

The focal concept of this study is health procrastination. Delay in seeking help from medical practitioners is an increasing problem in Latvia, particularly with men between the ages of 35-44. Failures in primary and secondary prevention create a number of negative consequences, for instance, longer and more complex treatment; lower recovery prognosis as well as higher treatment costs. Nevertheless, the aforementioned group often avoids medical treatment. The aim of this study was to understa...

СD44+/CD24- markers of cancer stem cells in patients with breast cancer of different molecular subtypes.

Science.gov (United States)

Chekhun, S V; Zadvorny, T V; Tymovska, Yu O; Anikusko, M F; Novak, O E; Polishchuk, L Z

2015-03-01

To determine frequency of tumors with immunohistochemical markers of cancer stem cells (CSC) CD44+/CD24- in patients with breast cancer (BC) of different molecular subtype and to evaluate their prognostic value. Surgical material of 132 patients with BC stage I-II, age from 23 to 75 years, mean age - 50.2 ± 3.1 years was studied. Clinical, immunohistochemical (expression CD44+/CD24-), morphological, statistical. BC is characterized by heterogeneity of molecular subtypes and expression of markers (CD44+/CD24-). Immunohistochemical study of expression of CSC markers in surgical material has detected their expression in 34 (25.4%) patients with BC of different molecular subtypes. The highest frequency of cells with expression of CSC marker was observed in patients with basal molecular subtype (44.8% patients). Most of BC patients with phenotype CD44+/CD24 had stage I of tumor process (34.3%). Statistical processing of data has showen that Yule colligation coefficient equaled 0.28 (р > 0.05) that argues poor correlation between stage of tumor process and number of tumors with positive expression of CSC markers. Statistical processing of data has showen high correlation between presence of cells with expression of CSC markers and metastases of BC in regional lymph nodes (Yule colligation coefficient equals 0.943; р molecular subtype depending on expression of CSC CD44+/CD24- markers was detected. Survival of patients with basal BC was reliably higher at lack in tumors of cells with CSC markers CD44+/CD24- and, correspondingly, lower at presence of such cells (р markers was not determined (р > 0.05). Significance of tumor cells with markers CD44+/CD24- within the limits of molecular subtype of BC may be additional criterion for advanced biological characteristic of BC, and in patients with BC of basal molecular subtype - for predictive evaluation of individual potential of tumor to aggressive clinical course.

Nutrition in the childbearing years

National Research Council Canada - National Science Library

Derbyshire, Emma

2011-01-01

... Other concerns 2.23 Application in practice 2.24 Conclusion xi xvii xviii xix xx 1 1 2 12 20 25 26 26 28 29 29 30 31 33 33 34 34 36 38 38 39 39 41 41 42 43 43 43 44 44vi Contents 3 4 5 6 Hormonal an...

ISIS annual report for the financial year 1 April 1988 to 31 March 1989

International Nuclear Information System (INIS)

1989-07-01

Over the past year, to 31st March 1989, ISIS has not only maintained its position as the world's most powerful pulsed neutron - and muon -source, but has made further notable strides forward. The operating current has increased, reliability has improved significantly, new instruments have come into operation, and new science has underlined yet again the major advantages of pulsed spallation sources. A new management structure was put in place during the year, and several bilateral agreements were finalised. (author)

Transplantation With Livers From Deceased Donors Older Than 75 Years

DEFF Research Database (Denmark)

Thorsen, Trygve; Aandahl, Einar Martin; Bennet, William

2015-01-01

BACKGROUND: The availability of donor organs limits the number of patients in need who are offered liver transplantation. Measures to expand the donor pool are crucial to prevent on-list mortality. The aim of this study was to evaluate the use of livers from deceased donors who were older than 75...... years. METHODS: Fifty-four patients who received a first liver transplant (D75 group) from 2001 to 2011 were included. Donor and recipient data were collected from the Nordic Liver Transplant Registry and medical records. The outcome was compared with a control group of 54 patients who received a liver...... graft from donors aged 20 to 49 years (D20-49 group). Median donor age was 77 years (range, 75-86 years) in the D75 group and 41 years (range, 20-49 years) in the D20-49 group. Median recipient age was 59 years (range, 31-73 years) in the D75 group and 58 years (range, 31-74 years) in the D20-49 group...

Ranging Behaviour of Commercial Free-Range Broiler Chickens 1: Factors Related to Flock Variability.

Science.gov (United States)

Taylor, Peta S; Hemsworth, Paul H; Groves, Peter J; Gebhardt-Henrich, Sabine G; Rault, Jean-Loup

2017-07-20

Little is known about the ranging behaviour of chickens. Understanding ranging behaviour is required to improve management and shed and range design to ensure optimal ranging opportunities. Using Radio Frequency Identification technology, we tracked 300 individual broiler chickens in each of four mixed sex ROSS 308 flocks on one commercial farm across two seasons. Ranging behaviour was tracked from the first day of range access (21 days of age) until 35 days of age in winter and 44 days of age in summer. Range use was higher than previously reported from scan sampling studies. More chickens accessed the range in summer (81%) than winter (32%; p range use was greater in summer flocks (4.4 ± 0.1 visits for a total of 26.3 ± 0.8 min/day) than winter flocks (3.2 ± 0.2 visits for a total of 7.9 ± 1.0 min/day). Seasonal differences were only marginally explained by weather conditions and may reflect the reduction in range exposure between seasons (number of days, hours per day, and time of day). Specific times of the day ( p ranging and external factors that may explain ranging preferences.

Cyclotron production of {sup 44}Sc for clinical application

Energy Technology Data Exchange (ETDEWEB)

Krajewski, S.; Bilewicz, A. [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Cydzik, I. [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); European Commission Joint Research Center, Ispra (Italy). Inst. for Health and Consumer Protection; Warsaw Univ. (Poland). Heavy Ion Lab.; Abbas, K. [European Commission Joint Research Center, Ispra (Italy). Institute for Transuranium Elements; Bulgheroni, A.; Simonelli, F.; Holzwarth, U. [European Commission Joint Research Center, Ispra (Italy). Inst. for Health and Consumer Protection

2013-08-01

{sup 44} is a promising {beta}{sup +}-emitter for molecular imaging with intermediate half-life of 4 h. Due to the chemical similarity of Sc{sup 3+} to the Lu{sup 3+} and Y{sup 3+} cations, {sup 44}Sc-DOTA bioconjugates are expected to demonstrate similar properties in vivo as the {sup 177}Lu- and {sup 90}Y-bioconjugates, what is important in planning the radionuclide therapy. {sup 44}Sc can be obtained from the {sup 44}Ti/{sup 44}Sc generator. An alternative method for {sup 44}Sc production can be the irradiation of {sup 44}Ca target at small cyclotrons. The aim of our work was to optimize the parameters of {sup 44}CaCO{sub 3} irradiation and to develop a simple procedure for {sup 44}Sc separation from the calcium target. For optimization study, {sup 44}CaCO{sub 3} targets were irradiated by protons in the energy range of 5.6-17.5 MeV with 9 MeV being found to be the best energy for {sup 44}Ca irradiations. A simple and fast separation procedure of {sup 44}Sc from calcium target was developed using chelating resin Chelex 100. DOTATATE conjugate was successfully radiolabelled with high yield at elevated temperature using the produced {sup 44}Sc. While {sup 44}CaCO{sub 3} is relatively expensive, the cost of {sup 44}Sc-DOTATATE production can be reduced by target recovery. Due to low proton energy required to produce GBq activity level of {sup 44}Sc, the availability of {sup 44}Sc radioisotope could be enhanced to open new opportunities for applications in medical imaging. (orig.)

Experience in the use of radioactive iodine therapy for ...

African Journals Online (AJOL)

The age range was 31 to 60 years, with a mean age of 44.2 ± 1.8 years. ... thyrotoxic heart disease, recurrent thyrotoxicosis and failed antithyroid drug therapy. ... patients, but a high rate of default precludes adequate long-term follow-up.

26 CFR 31.3402(g)-2 - Wages paid for payroll period of more than one year.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 15 2010-04-01 2010-04-01 false Wages paid for payroll period of more than one... COLLECTION OF INCOME TAX AT SOURCE Collection of Income Tax at Source § 31.3402(g)-2 Wages paid for payroll period of more than one year. If wages are paid to an employee for a payroll period of more than one year...

A 31 GHz Survey of Low-Frequency Selected Radio Sources

Science.gov (United States)

Mason, B. S.; Weintraub, L.; Sievers, J.; Bond, J. R.; Myers, S. T.; Pearson, T. J.; Readhead, A. C. S.; Shepherd, M. C.

2009-10-01

The 100 m Robert C. Byrd Green Bank Telescope and the 40 m Owens Valley Radio Observatory telescope have been used to conduct a 31 GHz survey of 3165 known extragalactic radio sources over 143 deg2 of the sky. Target sources were selected from the NRAO VLA Sky Survey in fields observed by the Cosmic Background Imager (CBI); most are extragalactic active galactic nuclei (AGNs) with 1.4 GHz flux densities of 3-10 mJy. The resulting 31 GHz catalogs are presented in full online. Using a maximum-likelihood analysis to obtain an unbiased estimate of the distribution of the 1.4-31 GHz spectral indices of these sources, we find a mean 31-1.4 GHz flux ratio of 0.110 ± 0.003 corresponding to a spectral index of α = -0.71 ± 0.01 (S ν vprop να) 9.0% ± 0.8% of sources have α > - 0.5 and 1.2% ± 0.2% have α > 0. By combining this spectral-index distribution with 1.4 GHz source counts, we predict 31 GHz source counts in the range 1 mJy S 31) = (16.7 ± 1.7) deg-2(S 31/1 mJy)-0.80±0.07. We also assess the contribution of mJy-level (S 1.4 GHz < 3.4 mJy) radio sources to the 31 GHz cosmic microwave background power spectrum, finding a mean power of ell(ell + 1)C src ell/(2π) = 44 ± 14 μK2 and a 95% upper limit of 80 μK2 at ell = 2500. Including an estimated contribution of 12 μK2 from the population of sources responsible for the turn-up in counts below S 1.4 GHz = 1 mJy, this amounts to 21% ± 7% of what is needed to explain the CBI high-ell excess signal, 275 ± 63 μK2. These results are consistent with other measurements of the 31 GHz point-source foreground.

Productivity Costs Associated With Breast Cancer Among Survivors Aged 18-44 Years.

Science.gov (United States)

Ekwueme, Donatus U; Trogdon, Justin G; Khavjou, Olga A; Guy, Gery P

2016-02-01

No study has quantified productivity losses associated with breast cancer in younger women aged 18-44 years. This study estimated productivity costs, including work and home productivity losses, among younger women who reported ever receiving a breast cancer diagnosis. A two-part regression model and 2000-2010 National Health Interview Survey data were used to estimate the number of work and home productivity days missed because of breast cancer, adjusted for socioeconomic characteristics and comorbidities. Estimates for younger women were compared with those for women aged 45-64 years. Data were analyzed in 2013-2014. Per capita, younger women with breast cancer had annual losses of $2,293 (95% CI=$1,069, $3,518) from missed work and $442 (95% CI=$161, $723) from missed home productivity. Total annual breast cancer-associated productivity costs for younger women were $344 million (95% CI=$154 million, $535 million). Older women with breast cancer had lower per capita work loss productivity costs of $1,407 (95% CI=$899, $1,915) but higher total work loss productivity costs estimated at $1,072 million (95% CI=$685 million, $1,460 million) than younger women. Younger women with a history of breast cancer face a disproportionate share of work and home productivity losses. Although older women have lower per capita costs, total productivity costs were higher for older women because the number of older women with breast cancer is higher. The results underscore the importance of continued efforts by the public health community to promote and support the unique needs of younger breast cancer survivors. Published by Elsevier Inc.

3d-4p x-ray spectrum emitted by highly ionized uranium from a laser-produced plasma in the 3.8<λ<4.4-A wavelength range

International Nuclear Information System (INIS)

Mandelbaum, P.; Seely, J.F.; Kania, D.R.; Kauffman, R.L.

1992-01-01

This work extends a previous analysis of the x-ray spectrum of a laser-produced uranium plasma [P. Mandelbaum et al., Phys. Rev. A 44, 5752 (1991)] to the longer-wavelength range (3.8 +65 ) through As-like (U +59 ) isoelectronic sequences are identified in the spectrum, in good agreement with the previous analysis of the spectrum emitted at shorter wavelengths

Comparing the range of μ and β angles in 6-17-year-old children of Isfahan with normal occlusion

Directory of Open Access Journals (Sweden)

Saeed Sadeghian

2014-01-01

Full Text Available Background: Linear and angular measurements such as A point, nasion, B point (ANB angle and Wits appraisal index are not accurate enough to evaluate sagittal relationship of the jaws. The aim of this study was to evaluate and compare the range of μ and β angles in 6-17-year-old children of Isfahan, having normal occlusion. Materials and Methods: This was an analytical descriptive study. For this study, 235 cephalometric radiographs of patients who didn′t receive orthodontics treatments and based on 13 indexes had normal occlusion, were selected. After tracing of cephalograms, ANB angle, Wits appraisal index, μ angle (resulted from the intersection of AB line and perpendicular line from point A to mandibular plane and β angle (resulted from the intersection of AB line and perpendicular line from point A on CB line were measured. Data was analyzed by t-test, ANOVA and Pierson-Spearman correlation coefficient (P < 0.05. Results: Mean value of μ and β angles were 17.34 ± 3.47 and 31.7 ± 3.31 and ranged from 8-27 to 21.5-39 respectively. According to t-test, there was a significant difference between two sex groups for μ angle (P = 0.02; however, it was not significant for β angle. According to Spearman correlation coefficient, there was no significant difference between age and μ angle; however, β angle was directly and significantly related to age (r = 0.435. There was significant and reverse relationship between μ and β angles with ANB angle and Wits appraisal index. Conclusion: μ and β angles are reliable and can be used to evaluate the anterior-posterior relationship of the jaws.

National Needs of Family Planning Among US Men Aged 15 to 44 Years

Science.gov (United States)

Gibbs, Susannah E.; Choiriyyah, Ifta; Sonenstein, Freya L.; Astone, Nan M.; Pleck, Joseph H.; Dariotis, Jacinda K.

2016-01-01

Objectives. To estimate national need for family planning services among men in the United States according to background characteristics, access to care, receipt of services, and contraception use. Methods. We used weighted data from the 2006–2010 National Survey of Family Growth to estimate the percentage of men aged 15 to 44 years (n = 10 395) in need of family planning, based on sexual behavior, fecundity, and not trying to get pregnant with his partner. Results. Overall, 60% of men were in need of family planning, defined as those who ever had vaginal sex, were fecund, and had fecund partner(s) who were not trying to get pregnant with partner or partner(s) were not currently pregnant. The greatest need was among young and unmarried men. Most men in need of family planning had access to care, but few reported receiving family planning services (family planning education and care is substantial and largely unmet despite national public health priorities to include men in reducing unintended pregnancies. PMID:26890180

ISIS annual report for the financial year 1 April 1991 to 31 March 1992. V. 2

International Nuclear Information System (INIS)

Wilson, C.

1992-07-01

This, Volume 11 of the 1992 Annual Report of ISIS the neutron scattering facility at Rutherford Appleton Laboratory contains the Experimental Reports on those experiments carried out on ISIS in the year ending 31 March 1992. Included are Experimental Reports from work performed on 14 ISIS instruments (13 neutron and one muon beam), and the number and quality of these reports reflects very well upon the standard of experiments performed at the Facility. The continuing increase in productivity of ISIS, which has extended through the initial development stage of the source, demonstrates that much new science continues to be done at ISIS, and that with the development and provision of new instruments, the scientific output of the Facility will continue to show strong growth. These Experimental Reports are intended as interim summaries of the measurements made during an ISIS experiment and as such may not contain the final conclusions of the analysis. They do, however, give a general flavour of the range and type of science performed on each instrument. (author)

Report and accounts of the United Kingdom Atomic Energy Authority for the year ended 31 March 1986

International Nuclear Information System (INIS)

1986-03-01

The report and accounts of the United Kingdom Atomic Energy Authority for the year ended 31 March 1986 is presented. The contents include: a) a general report, b) technical report, c) facilities, expertise and organisation, d) accounts. (UK)

A 44-year-old woman with metabolic acidosis, high anion gap, and delayed neurologic deterioration.

Science.gov (United States)

Vakil, Abhay; Upadhyay, Hinesh; Sherani, Khalid; Cervellione, Kelly; Trepeta, Scott; Patel, Mahendra C

2015-01-01

A 44-year-old woman was brought to the ED from John F. Kennedy International Airport. The patient was returning with her son from a 3-month visit to Bangladesh. Her journey started with a 4-h flight from Dhaka, Bangladesh to Dubai, United Arab Emirates. She consumed 240 mL of whiskey during the flight. This was followed by a 14-h flight from Dubai to New York. According to the patient's son, she did not consume any alcohol during the second flight. The patient was in her usual state of health with normal mentation throughout her journey. Upon landing, she started complaining of shortness of breath. After disembarking, she was witnessed to have seizure-like activity with involuntary passage of urine, following which she collapsed. The patient was intubated by emergency medical services in the field.

26 CFR 301.6501(j)-1 - Investment credit carryback; taxable years ending after December 31, 1961.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Investment credit carryback; taxable years ending after December 31, 1961. 301.6501(j)-1 Section 301.6501(j)-1 Internal Revenue INTERNAL REVENUE... Limitations Limitations on Assessment and Collection § 301.6501(j)-1 Investment credit carryback; taxable...

Study of the gamma emission from the 31-year isomer of 178Hf induced by X-ray irradiation

International Nuclear Information System (INIS)

Collins, C.B.; Davanloo, F.; Iosif, M.C.

1999-01-01

A sample containing 6.3x10 14 nuclei of the 16 + isomer of 178 Hf having a half-life of 31 years and excitation energy of 2.446 MeV was irradiated with x-ray pulses derived from a device operated at 15mA to produce Bremsstrahlung radiation with an end point energy set to be 90 keV. Gamma-spectra of the isomeric target were taken with a Ge-detector. Intensity of the 325.5 keV (6 + →4 + transition in the ground state band of 178 Hf was found to increase by about 2%. Such an accelerated decay of the 178 Hf isomer is consistent with an integrated cross section of 3x10 -23 cm 2 ·keV if the resonant absorption takes place within the energy ranges corresponding to the maxima of the x-ray flux, either near 20 keV, or at the K emission lines of W

Seventy years of stream‐fish collections reveal invasions and native range contractions in an Appalachian (USA) watershed

Science.gov (United States)

Buckwalter, Joseph D.; Frimpong, Emmanuel A.; Angermeier, Paul L.; Barney, Jacob N.

2018-01-01

AimKnowledge of expanding and contracting ranges is critical for monitoring invasions and assessing conservation status, yet reliable data on distributional trends are lacking for most freshwater species. We developed a quantitative technique to detect the sign (expansion or contraction) and functional form of range‐size changes for freshwater species based on collections data, while accounting for possible biases due to variable collection effort. We applied this technique to quantify stream‐fish range expansions and contractions in a highly invaded river system.LocationUpper and middle New River (UMNR) basin, Appalachian Mountains, USA.MethodsWe compiled a 77‐year stream‐fish collections dataset partitioned into ten time periods. To account for variable collection effort among time periods, we aggregated the collections into 100 watersheds and expressed a species’ range size as detections per watershed (HUC) sampled (DPHS). We regressed DPHS against time by species and used an information‐theoretic approach to compare linear and nonlinear functional forms fitted to the data points and to classify each species as spreader, stable or decliner.ResultsWe analysed changes in range size for 74 UMNR fishes, including 35 native and 39 established introduced species. We classified the majority (51%) of introduced species as spreaders, compared to 31% of natives. An exponential functional form fits best for 84% of spreaders. Three natives were among the most rapid spreaders. All four decliners were New River natives.Main conclusionsOur DPHS‐based approach facilitated quantitative analyses of distributional trends for stream fishes based on collections data. Partitioning the dataset into multiple time periods allowed us to distinguish long‐term trends from population fluctuations and to examine nonlinear forms of spread. Our framework sets the stage for further study of drivers of stream‐fish invasions and declines in the UMNR and is widely transferable to

44 CFR 208.44 - Reimbursement for other costs.

Science.gov (United States)

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Reimbursement for other costs... Cooperative Agreements § 208.44 Reimbursement for other costs. (a) Except as allowed under paragraph (b) of this section, DHS will not reimburse other costs incurred preceding, during or upon the conclusion of...

A case of premature ovarian failure (POF) in a 31-year-old woman with a 47,XXX karyotype.

Science.gov (United States)

Skałba, Piotr; Cygal, Anna; Gierzyńska, Zuzanna

2010-01-01

A case of POF in a 31-year-old woman with karyotype 47,XXX. The aim of the study was to discuss a case of POF in a 31-year-old patient with polysomy 47,XXX. The described karyotype is not usually associated with this characteristic physical phenotype. In some rare cases, menstrual disorders, sterility, secondary amenorrhoea, premature menopause, and low intelligence are found. Our observations revealed the necessity for cytogenetic examination in all women at reproductive age with symptoms of premature ovarian failure. According to the data found in literature, patients with POF and karyotype disorders belong to the risk group of premature death, mostly for cardiological reasons. Raising patient awareness about the risk may have a positive effect on quality of life and regularity of check-ups.

31 CFR 535.502 - Effect of license or authorization.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Effect of license or authorization. 535.502 Section 535.502 Money and Finance: Treasury Regulations Relating to Money and Finance... respect to, any property which would not otherwise exist under ordinary principles of law. [44 FR 66833...

Pre-eruptive conditions of the ~31 ka rhyolitic magma of Tlaloc volcano, Sierra Nevada Volcanic Range, Central Mexico

Science.gov (United States)

Macias, J.; Arce, J.; Rueda, H.; Gardner, J.

2008-12-01

Tlaloc volcano is located at the northern tip of the Sierra Nevada Volcanic Range in Central Mexico. This Pleistocene to Recent volcanic range consists from north to south of Tlaloc-Telapón-Teyotl-Iztaccíhuatl-and- Popocatépetl volcanoes. While andesitic to barely dacitic volcanism dominates the southern part of the range (i.e. Popocatépetl and Iztaccíhuatl); dacitic and rare rhyolithic volcanism (i.e. Telapón, Tlaloc) dominates the northern end. The known locus of rhyolitic magmatism took place at Tlaloc volcano with a Plinian-Subplinian eruption that occurred 31 ka ago. The eruption emplaced the so-called multilayered fallout and pumiceous pyroclastic flows (~2 km3 DRE). The deposit consists of 95% vol. of juvenile particles (pumice + crystals) and minor altered lithics 5% vol. The mineral association of the pumice fragments (74-76 % wt. SiO2) consists of quartz + plagioclase + sanidine + biotite and rare oxides set in a glassy groundmass with voids. Melt inclusions in quartz phenocrysts suggest that prior to the eruption the rhyolitic contain ~7% of H2O and Nevado de Toluca volcano (~6 km) some 50 km to the southwest.

Long-range transport of Asian pollution to the northeast Pacific: Seasonal variations and transport pathways of carbon monoxide

Science.gov (United States)

Liang, Qing; Jaeglé, Lyatt; Jaffe, Daniel A.; Weiss-Penzias, Peter; Heckman, Anna; Snow, Julie A.

2004-12-01

Continuous CO measurements were obtained at Cheeka Peak Observatory (CPO, 48.3°N, 124.6°W, 480 m), a coastal site in Washington state, between 9 March 2001 and 31 May 2002. We analyze these observations as well as CO observations at ground sites throughout the North Pacific using the GEOS-CHEM global tropospheric chemistry model to examine the seasonal variations of Asian long-range transport. The model reproduces the observed CO levels, their seasonal cycle and day-to-day variability, with a 5-20 ppbv negative bias in winter/spring and 5-10 ppbv positive bias during summer. Asian influence on CO levels in the North Pacific troposphere maximizes during spring and minimizes during summer, ranging from 91 ppbv (44% of total CO) to 52 ppbv (39%) along the Asian Pacific Rim and from 44 ppbv (30%) to 24 ppbv (23%) at CPO. Maximum export of Asian pollution to the western Pacific occurs at 20°-50°N during spring throughout the tropospheric column, shifting to 30°-60°N during summer, mostly in the upper troposphere. The model captures five particularly strong transpacific transport events reaching CPO (four in spring, one in winter) resulting in 20-40 ppbv increases in observed CO levels. Episodic long-range transport of pollutants from Asia to the NE Pacific occurs throughout the year every 10, 15, and 30 days in the upper, middle, and lower troposphere, respectively. Lifting ahead of cold fronts followed by transport in midlatitude westerlies accounts for 78% of long-range transport events reaching the NE Pacific middle and upper troposphere. During summer, convective injection into the upper troposphere competes with frontal mechanisms in this export. Most events reaching the NE Pacific lower troposphere below 2 km altitude result from boundary layer outflow behind cold fronts (for spring) or ahead of cold fronts (for other seasons) followed by low-level transpacific transport.

50 CFR 680.44 - Cost recovery.

Science.gov (United States)

2010-10-01

...) Publication—(i) General. During the first quarter of each crab fishing year, NMFS shall calculate the crab fee... Management Measures § 680.44 Cost recovery. (a) Cost recovery fees—(1) Responsibility. The person documented... holder's liability for noncompliance with this section. (2) Fee liability determination. (i) All CR...

Expression of CD44v6 and Its Association with Prognosis in Epithelial Ovarian Carcinomas

Directory of Open Access Journals (Sweden)

Dang-xia Zhou

2012-01-01

Full Text Available The aim of this study was to evaluate CD44v6 protein expression and its prognostic value of CD44v6 in ovarian carcinoma. The expression of CD44v6 was analyzed in 62 patients with ovarian carcinoma by immunohistochemical method. The data obtained were analyzed by univariate and multivariate analyses. The present study clearly demonstrates that tumor tissues from 41 (66.1% patients showed positive expression with CD44v6. The expression of CD44v6 was significantly correlated with histological type, FIGO stage and histological grade of ovarian carcinomas. Concerning the prognosis, the survival period of patients with CD44v6 positive was shorter than that of patients with CD44v6 negative (36.6% versus 66.7%, 5-year survival, P<0.05. Univariate analysis showed that CD44v6 expression, histological type, FIGO stage and histological grade were associated with 5-year survival, and CD44v6 expression was associated with histological type, FIGO stage and histological grade and 5-year survival. In multivariate analysis, using the COX-regression model, CD44v6 expression was important prognostic factor. In conclusion, these results suggest that CD44v6 may be related to histological type, FIGO stage and histological grade of ovarian carcinomas, and CD44v6 may be an important molecular marker for poor prognosis in ovarian carcinomas.

Radiological and pathological analysis of LDCT screen detected and surgically resected sub-centimetre lung nodules in 44 asymptomatic patients

International Nuclear Information System (INIS)

Hu, Xing; Zhao, Jiangmin; Qian, Haishan; Du, Guangyan; Kelly, Margaret; Yang, Hua

2016-01-01

Once lung cancer is detected due to clinical symptoms or by being visible on chest X-ray, it is usually high stage and non-operable. In order to improve mortality rates in lung cancer, low-dose CT (LDCT) screening of “high risk” individuals is gaining popularity. However, the rate of malignancy in LDCT detected sub-centimetre lung nodules is not clear. We aimed to analyze surgically resected specimens in this patient group to explore cost effectiveness and recommendations for clinical management of these nodules. Our hospital pathology database was searched for sub-centimeter lung nodules detected by LDCT screening which were resected. The patient demographics were collected and the radiologic and pathologic characteristics of those nodules were analyzed. From the records, 44 patients with 46 resected subcentimetre nodules were identified. Patients were selected for surgery based on an irregular shape, growth in size during follow up, family history of lung cancer or personal history of cancer of other sites, previous lung disease, smoking and personal anxiety. Of the 44 patients, 33 were women and the ages ranged from 43 to 76 years (56.75 ± 8.44). All nodules were equal to, or less than 10 mm with a mean diameter of 7.81 ± 1.80 mm (SD). Out of 46 nodules, the pathological diagnoses were: invasive adenocarcinoma (ACa) in 4 (8.7%); adenocarcinoma in situ (AIS) or atypical adenomatous hyperplasia (AAH) in 29 (63%); benign fibrosis/fibrotic scar with inflammation or calcification in 12 (26.1%); an intrapulmonary benign lymph node in 1 (2.2%). Of the ACa, AIS and AAH groups (a total of 31 patients), 77% were women (24 vs. 7). The cancer or pre-cancer nodules (ACa, AIS and AAH) tended to be larger than benign fibrotic scars (P = 0.039). Amongst all characteristics, significant statistical differences were found when the following radiological features were considered: reconstructed nodule shape (P = 0.011), margin (P = 0.003) and ground glass pattern (P = 0

Case report of Lewy body disease mimicking Creutzfeldt-Jakob disease in a 44-year-old man.

Science.gov (United States)

Saint-Aubert, Laure; Pariente, Jérémie; Dumas, Herve; Payoux, Pierre; Brandel, Jean-Philippe; Puel, Michèle; Vital, Anne; Guedj, Eric; Lesage, Suzanne; Peoc'h, Katell; Brefel Courbon, Christine; Ory Magne, Fabienne

2016-07-30

Few patients are reported with dementia with Lewy bodies before fifty years-old, which may partly reflect the difficulty of accurate diagnosis in young population. We report the case of a 44-year-old male with pathologically confirmed sporadic dementia with Lewy bodies, who did not fulfil the revised clinical criteria for this disease. We document this atypical case with clinical and cognitive evaluation, imaging, biochemistry, genetics and pathology investigations. Creutzfeldt-Jakob disease was first suspected in this patient with no previous medical history, who developed acute and rapid cognitive impairment, L-dopa-non-responsive parkinsonism, and delusion. Positive 14-3-3 protein was initially detected in cerebrospinal fluid and until the late stages of the disease. Severe atrophy with no diffusion hypersignal was found on structural MRI as well as an extensive hypometabolism on (18)F-FDG-PET, in comparison to age-matched healthy volunteers. Genetic investigation found no alpha-synuclein gene mutation. The patient died within 5 years, and post-mortem examination found numerous Lewy bodies and Lewy neurites consistent with pure Lewy body disease. This comprehensively described case illustrates that dementia with Lewy bodies can occur in young patients with atypical clinical presentation. Biochemistry and neuroimaging investigations can sometimes be insufficient to allow accurate diagnostic. More specific markers to support such diagnosis are needed.

29 CFR 570.31 - Secretary's determinations concerning the employment of minors 14 and 15 years of age.

Science.gov (United States)

2010-07-01

... AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS CHILD LABOR REGULATIONS, ORDERS AND STATEMENTS OF INTERPRETATION Employment of Minors Between 14 and 16 Years of Age (Child Labor Reg. 3) § 570.31 Secretary's... or with their health and well-being and shall not be deemed to be oppressive child labor. Effective...

Valvular Abnormalities Detected by Echocardiography in 5-Year Survivors of Childhood Cancer: A Long-Term Follow-Up Study

International Nuclear Information System (INIS)

Pal, Helena J. van der; Dijk, Irma W. van; Geskus, Ronald B.; Kok, Wouter E.; Koolen, Marianne; Sieswerda, Elske; Oldenburger, Foppe; Koning, Caro C.; Leeuwen, Flora E. van; Caron, Huib N.; Kremer, Leontien C.; Dalen, Elvira C. van

2015-01-01

Purpose: To determine the prevalence of valvular abnormalities after radiation therapy involving the heart region and/or treatment with anthracyclines and to identify associated risk factors in a large cohort of 5-year childhood cancer survivors (CCS). Methods and Materials: The study cohort consisted of all 626 eligible 5-year CCS diagnosed with childhood cancer in the Emma Children's Hospital/Academic Medical Center between 1966 and 1996 and treated with radiation therapy involving the heart region and/or anthracyclines. We determined the presence of valvular abnormalities according to echocardiograms. Physical radiation dose was converted into the equivalent dose in 2-Gy fractions (EQD 2 ). Using multivariable logistic regression analyses, we examined the associations between cancer treatment and valvular abnormalities. Results: We identified 225 mainly mild echocardiographic valvular abnormalities in 169 of 545 CCS (31%) with a cardiac assessment (median follow-up time, 14.9 years [range, 5.1-36.8 years]; median attained age 22.0 years [range, 7.0-49.7 years]). Twenty-four CCS (4.4%) had 31 moderate or higher-graded abnormalities. Most common abnormalities were tricuspid valve disorders (n=119; 21.8%) and mitral valve disorders (n=73; 13.4%). The risk of valvular abnormalities was associated with increasing radiation dose (using EQD 2 ) involving the heart region (odds ratio 1.33 per 10 Gy) and the presence of congenital heart disease (odds ratio 3.43). We found no statistically significant evidence that anthracyclines increase the risk. Conclusions: Almost one-third of CCS treated with potentially cardiotoxic therapy had 1 or more asymptomatic, mostly mild valvular abnormalities after a median follow-up of nearly 15 years. The most important risk factors are higher EQD 2 to the heart region and congenital heart disease. Studies with longer follow-up are necessary to investigate the clinical course of asymptomatic valvular abnormalities in CCS

Valvular Abnormalities Detected by Echocardiography in 5-Year Survivors of Childhood Cancer: A Long-Term Follow-Up Study

Energy Technology Data Exchange (ETDEWEB)

Pal, Helena J. van der, E-mail: h.j.vanderpal@amc.uva.nl [Department of Medical Oncology, Emma Children' s Hospital/Academic Medical Center, Amsterdam (Netherlands); Department of Pediatric Oncology, Emma Children' s Hospital/Academic Medical Center, Amsterdam (Netherlands); Dijk, Irma W. van [Department of Radiation Oncology, Emma Children' s Hospital/Academic Medical Center, Amsterdam (Netherlands); Geskus, Ronald B. [Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Emma Children' s Hospital/Academic Medical Center, Amsterdam (Netherlands); Kok, Wouter E. [Department of Cardiology, Emma Children' s Hospital/Academic Medical Center, Amsterdam (Netherlands); Koolen, Marianne; Sieswerda, Elske [Department of Pediatric Oncology, Emma Children' s Hospital/Academic Medical Center, Amsterdam (Netherlands); Oldenburger, Foppe; Koning, Caro C. [Department of Radiation Oncology, Emma Children' s Hospital/Academic Medical Center, Amsterdam (Netherlands); Leeuwen, Flora E. van [Department of Epidemiology, Netherlands Cancer Institute, Amsterdam (Netherlands); Caron, Huib N.; Kremer, Leontien C.; Dalen, Elvira C. van [Department of Pediatric Oncology, Emma Children' s Hospital/Academic Medical Center, Amsterdam (Netherlands)

2015-01-01

Purpose: To determine the prevalence of valvular abnormalities after radiation therapy involving the heart region and/or treatment with anthracyclines and to identify associated risk factors in a large cohort of 5-year childhood cancer survivors (CCS). Methods and Materials: The study cohort consisted of all 626 eligible 5-year CCS diagnosed with childhood cancer in the Emma Children's Hospital/Academic Medical Center between 1966 and 1996 and treated with radiation therapy involving the heart region and/or anthracyclines. We determined the presence of valvular abnormalities according to echocardiograms. Physical radiation dose was converted into the equivalent dose in 2-Gy fractions (EQD{sub 2}). Using multivariable logistic regression analyses, we examined the associations between cancer treatment and valvular abnormalities. Results: We identified 225 mainly mild echocardiographic valvular abnormalities in 169 of 545 CCS (31%) with a cardiac assessment (median follow-up time, 14.9 years [range, 5.1-36.8 years]; median attained age 22.0 years [range, 7.0-49.7 years]). Twenty-four CCS (4.4%) had 31 moderate or higher-graded abnormalities. Most common abnormalities were tricuspid valve disorders (n=119; 21.8%) and mitral valve disorders (n=73; 13.4%). The risk of valvular abnormalities was associated with increasing radiation dose (using EQD{sub 2}) involving the heart region (odds ratio 1.33 per 10 Gy) and the presence of congenital heart disease (odds ratio 3.43). We found no statistically significant evidence that anthracyclines increase the risk. Conclusions: Almost one-third of CCS treated with potentially cardiotoxic therapy had 1 or more asymptomatic, mostly mild valvular abnormalities after a median follow-up of nearly 15 years. The most important risk factors are higher EQD{sub 2} to the heart region and congenital heart disease. Studies with longer follow-up are necessary to investigate the clinical course of asymptomatic valvular abnormalities

Law No. 31 for the year 2002 on the prevention of radiation

International Nuclear Information System (INIS)

2002-01-01

The Law No. 31 for the year 2002 on the prevention of radiation contains 19 rules. This law contains articles on several things, including: the supervisory authority may regulate and control the use of radioactive materials and the prevention of hazards through the development of border and national standards for all radiological exposures and the development of regulations and guidance and control of radioactive waste, and also includes the formation of a technical committee called the 'Commission on Radiation Protection' jurisdiction preparing plans for protection from radiation hazards in the State of Qatar and licensing of personal and institutional for this area. The law also contains the sanctions regime imposed by the State on violators in the area of radiation

Erythema persists longer than one year in split-thickness skin graft donor sites

DEFF Research Database (Denmark)

Danielsen, Patricia L; Jorgensen, Lars N; Jørgensen, Bo

2013-01-01

on the thigh using a pneumatic dermatome in 19 consecutive Caucasian patients, median age 70 years, age range 44-86 years, who were undergoing skin graft surgery for leg ulcers. Transepidermal water loss (TEWL), erythema and pigmentation were measured quantitatively using non-invasive devices...

10 CFR 905.31 - Term.

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Term. 905.31 Section 905.31 Energy DEPARTMENT OF ENERGY ENERGY PLANNING AND MANAGEMENT PROGRAM Power Marketing Initiative § 905.31 Term. Western will extend resource commitments for 20 years from the date existing contracts expire to existing customers with long...

Fate of patients during the first year of dialysis

Directory of Open Access Journals (Sweden)

Selma Siham El Khayat

2013-01-01

Full Text Available Care in dialysis is often associated with significant morbidity and mortality during the first year. Knowledge of its magnitude and causes could improve the prognosis of these patients. The aim of this study was to evaluate the survival and morbidity during the first year of dialysis for patients who initiated their dialysis between January 1, 2009 and December 31, 2009 and to study their possible correlation with baseline status at the beginning of treatment. A multi-center retrospective study was conducted in 11 dialysis centers. Clinical data at the beginning of dialysis and during the following year were collected. Mortality and morbidity risk factors were assessed by comparing different groups. Statistical analysis was performed with SPSS version 11. This study involved 134 patients, 79 men and 55 women, of whom 132 were on hemodialysis and two patients were on peritoneal dialysis. The mean age at initiation of treatment was 54.37 ± 18.09 years. Initial causes of nephropathy were dominated by diabetes (44.02% and hypertension (11.19%. Among these patients, 39.55% had never received prior nephrological follow-up and 64.92% had started renal replacement therapy on an emergency basis. The initial clinical state was dominated by the presence of hypertension (50.74%, diabetes (44.02%, coronary insufficiency (13.43% and heart failure (7.46%. Only 26.86% of the incident patients showed no comorbidity. During the first year of follow-up, 37.31% of the patients experienced at least one episode of comorbidity. Hospitalization was necessary in about half of these cases (17.91% of all patients. The overall mortality rate was 14.17%. One patient received a kidney transplant. The mortality rate in the first year of dialysis was lower in our study than in other series. Regular nephrological follow-up of these patients before they reach end-stage could have a significant influence on survival in dialysis.

Complete Genome Sequences of 44 Arthrobacter Phages.

Science.gov (United States)

Klyczek, Karen K; Jacobs-Sera, Deborah; Adair, Tamarah L; Adams, Sandra D; Ball, Sarah L; Benjamin, Robert C; Bonilla, J Alfred; Breitenberger, Caroline A; Daniels, Charles J; Gaffney, Bobby L; Harrison, Melinda; Hughes, Lee E; King, Rodney A; Krukonis, Gregory P; Lopez, A Javier; Monsen-Collar, Kirsten; Pizzorno, Marie C; Rinehart, Claire A; Staples, Amanda K; Stowe, Emily L; Garlena, Rebecca A; Russell, Daniel A; Cresawn, Steven G; Pope, Welkin H; Hatfull, Graham F

2018-02-01

We report here the complete genome sequences of 44 phages infecting Arthrobacter sp. strain ATCC 21022. These phages have double-stranded DNA genomes with sizes ranging from 15,680 to 70,707 bp and G+C contents from 45.1% to 68.5%. All three tail types (belonging to the families Siphoviridae , Myoviridae , and Podoviridae ) are represented. Copyright © 2018 Klyczek et al.

Augmentation mastopexy in muscle-splitting biplane: outcome of first 44 consecutive cases of mastopexies in a new pocket.

Science.gov (United States)

Khan, Umar Daraz

2010-06-01

Augmentation with mastopexy is a commonly performed procedure and is done either simultaneously or in stages. The augmentation component can be accomplished by placing an implant in the subglandular, partial submuscular, or subfascial plane, and mastopexy can be performed using periareolar, vertical, or Wise pattern markings. These two components are independent of each other and any pocket can be combined with suitable external markings. The muscle-splitting submuscular biplane is a new pocket and is combined with conventional envelope reductions for mastopexy. The submuscular biplane pocket was used in 44 consecutive patients for mastopexy and augmentation using vertical scar and periareolar markings. Of these, 13 had subglandular augmentation in the past. The mean age of the patients was 32.4 years (range = 21-46). Average blood loss was 44 g (range = 10-111 g). Drains were used selectively and the procedure was usually done as a day case. The follow-up period of the included cases ranged from 4 months to 3 years. No infection, hematoma, or wound problems were seen. Minor revision was required for periareolar puckering in one case and three had dog-ears after vertical scar mastopexy. One periareolar mastopexy required conversion into a vertical scar as a revision and one vertical scar mastopexy had superficial infection with bilateral minor skin breakdown which responded completely to antibiotics. The submuscular biplane technique is a good option for breast augmentation with mastopexy as a single or staged procedure.

COLLAPSING HOT MOLECULAR CORES: A MODEL FOR THE DUST SPECTRUM AND AMMONIA LINE EMISSION OF THE G31.41+0.31 HOT CORE

International Nuclear Information System (INIS)

Osorio, Mayra; Anglada, Guillem; Lizano, Susana; D'Alessio, Paola

2009-01-01

We present a model aimed to reproduce the observed spectral energy distribution (SED) as well as the ammonia line emission of the G31.41+0.31 hot core. The hot core is modeled as an infalling envelope onto a massive star that is undergoing an intense accretion phase. We assume an envelope with a density and velocity structure resulting from the dynamical collapse of a singular logatropic sphere. The stellar and envelope physical properties are determined by fitting the observed SED. From these physical conditions, the emerging ammonia line emission is calculated and compared with subarcsecond resolution VLA data of the (4,4) transition taken from the literature. The only free parameter in this line fitting is the ammonia abundance. The observed intensities of the main and satellite ammonia (4,4) lines and their spatial distribution can be well reproduced provided the steep increase of the gas-phase ammonia abundance in the hotter (>100 K), inner regions of the core produced by the sublimation of icy mantles where ammonia molecules are trapped is taken into account. The model predictions for the (2,2), (4,4), and (5,5) transitions, obtained with the same set of parameters, are also reasonably in agreement, given the observational uncertainties, with the single-dish spectra of the region available in the literature. The best fit is obtained for a model with a central star of ∼25M sun , a mass accretion rate of ∼3 x 10 -3 M sun yr -1 , and a total luminosity of ∼2 x 10 5 L sun . The outer radius of the envelope is 30,000 AU, where kinetic temperatures as high as ∼40 K are reached. The gas-phase ammonia abundance ranges from ∼2 x 10 -8 in the outer region to ∼3 x 10 -6 in the inner region. To our knowledge, this is the first time that the dust and molecular line data of a hot molecular core, including subarcsecond resolution data that spatially resolve the structure of the core, have been simultaneously explained by a detailed, physically self

Downregulation of CD44 reduces doxorubicin resistance of CD44+CD24- breast cancer cells

Directory of Open Access Journals (Sweden)

Phuc PV

2011-06-01

Full Text Available Pham Van Phuc, Phan Lu Chinh Nhan, Truong Hai Nhung, Nguyen Thanh Tam, Nguyen Minh Hoang, Vuong Gia Tue, Duong Thanh Thuy, Phan Kim NgocLaboratory of Stem Cell Research and Application, University of Science, Vietnam National University, Ho Chi Minh, VietnamBackground: Cells within breast cancer stem cell populations have been confirmed to have a CD44+CD24- phenotype. Strong expression of CD44 plays a critical role in numerous types of human cancers. CD44 is involved in cell differentiation, adhesion, and metastasis of cancer cells.Methods: In this study, we reduced CD44 expression in CD44+CD24- breast cancer stem cells and investigated their sensitivity to an antitumor drug. The CD44+CD24- breast cancer stem cells were isolated from breast tumors; CD44 expression was downregulated with siRNAs followed by treatment with different concentrations of the antitumor drug.Results: The proliferation of CD44 downregulated CD44+CD24- breast cancer stem cells was decreased after drug treatment. We noticed treated cells were more sensitive to doxorubicin, even at low doses, compared with the control groups.Conclusions: It would appear that expression of CD44 is integral among the CD44+CD24- cell population. Reducing the expression level of CD44, combined with doxorubicin treatment, yields promising results for eradicating breast cancer stem cells in vitro. This study opens a new direction in treating breast cancer through gene therapy in conjunction with chemotherapy.Keywords: antitumor drugs, breast cancer stem cells, CD44, CD44+CD24- cells, doxorubicin

[Thrombosis in vascular accesses for haemodialysis: rescue treatment using invasive vascular radiological techniques].

Science.gov (United States)

García Medina, J; Lacasa Pérez, N; Muray Cases, S; Pérez Garrido, I; García Medina, V

2009-01-01

The purpose of this paper is to communicate our experience in the salvage of thrombosed haemodialysis vascular accesses using interventional radiology techniques. In the last four years, we have treated, by radiological means, 101 thrombosed haemodialysis vascular accesses. There were 44 autologous arteriovenous fistulas (43.56%) and 57 PTFE grafts (56.44%). There were 69 men (68.3%) and 32 women (31.7%). The mean age was 67.73 years (range 33-84). The mean vascular access age was 23.79 months (range 1-132). Manual catheter-directed aspiration was used. Fragmented, triturated or pushed the thrombus against the pulmonary circulation was avoided in all cases. 78 accesses were salvaged (77.2%). Autologous fistulas average and PTFE grafts success rate were 84.44% and 71.42% respectively. Angioplasty in one or more lesions after thromboaspiration was performed in all accesses, except six (5.9%). Metallic endoprostheses were implanted in 14 accesses (13.9%). Mean follow-up was 9 months (range 0-44). Primary patency was 42.3% +/- 5 at 6 months and 32% +/- 4 at one year. Autologous fistulas patency was better than PTFE grafts patency (p better than PTFE grafts. This justifies interventional radiology techniques in these situations.

HATS-43b, HATS-44b, HATS-45b, and HATS-46b: Four Short-period Transiting Giant Planets in the Neptune–Jupiter Mass Range

Science.gov (United States)

Brahm, R.; Hartman, J. D.; Jordán, A.; Bakos, G. Á.; Espinoza, N.; Rabus, M.; Bhatti, W.; Penev, K.; Sarkis, P.; Suc, V.; Csubry, Z.; Bayliss, D.; Bento, J.; Zhou, G.; Mancini, L.; Henning, T.; Ciceri, S.; de Val-Borro, M.; Shectman, S.; Crane, J. D.; Arriagada, P.; Butler, P.; Teske, J.; Thompson, I.; Osip, D.; Díaz, M.; Schmidt, B.; Lázár, J.; Papp, I.; Sári, P.

2018-03-01

We report the discovery of four short-period extrasolar planets transiting moderately bright stars from photometric measurements of the HATSouth network coupled to additional spectroscopic and photometric follow-up observations. While the planet masses range from 0.26 to 0.90 {M}{{J}}, the radii are all approximately a Jupiter radii, resulting in a wide range of bulk densities. The orbital period of the planets ranges from 2.7 days to 4.7 days, with HATS-43b having an orbit that appears to be marginally non-circular (e = 0.173 ± 0.089). HATS-44 is notable for having a high metallicity ([{Fe}/{{H}}] = 0.320 ± 0.071). The host stars spectral types range from late F to early K, and all of them are moderately bright (13.3 Carnegie Institute is operated by PU in conjunction with PUC, the station at the High Energy Spectroscopic Survey (H.E.S.S.) site is operated in conjunction with MPIA, and the station at Siding Spring Observatory (SSO) is operated jointly with ANU. This paper includes data gathered with the MPG 2.2 m and ESO 3.6 m telescopes at the ESO Observatory in La Silla. This paper includes data gathered with the 6.5 meter Magellan Telescopes located at Las Campanas Observatory, Chile.

Prevalence of significant bacteriuria among symptomatic and ...

African Journals Online (AJOL)

Data were analyzed using the Statistical Package for Social Sciences (SPSS) version 16.0 (SPSS, Inc., Chicago, Ill). Results: A total of 100 consenting participants were recruited into the study. The mean age was: 23.42 ± 8.31 years and a range of 14‑50 years. Only 9% (9/100) had significant bacteriuria while 44.4% (4/9) ...

44 CFR 13.26 - Non-Federal audit.

Science.gov (United States)

2010-10-01

... awards in a fiscal year, shall: (1) Determine whether State or local subgrantees have met the audit... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Non-Federal audit. 13.26... STATE AND LOCAL GOVERNMENTS Post-Award Requirements Financial Administration § 13.26 Non-Federal audit...

[Lung cancer in Avila province, Spain. Incidence rates, epidemiolgy of the year 2012 and trends in the last 20 years].

Science.gov (United States)

Hernández-Hernández, J R; Moreno de Vega-Herrero, M B; Iglesias-Heras, M; García-García, R; Hernández-Terciado, F; Celdrán-Gil, J

2015-10-01

To determine the extent of lung cancer in Alvila. Its incidence rates and significant epidemiological aspects of the year 2012 were recorded, and the results of each 5-year period (up to 20 years) were compared with those of known studies conducted using the same methodology. A prospective study was conducted on all patients diagnosed with lung cancer in the Province of Avila throughout the year 2012. A total of 81 patients were diagnosed, of whom 70 were males and 11 females, with a mean age of 72.1 years (range: 44-91), and was higher than that found in previous studies. This gave gross, and adjusted to the standard world population, incidence rates in 2012 of 80.99 and 31.23 per 100,000, respectively, in males, and 12.97 and 5.68 per 100,000, respectively in females. These rates are lower in both sexes than those found in Alvila in 2002. In 2012, 80.25% had been smokers (90% of males and 18.18% of the women), although, on diagnosis, 68.75% had quit smoking. A clinical-radiological diagnosis was made in 9 (11.1%), with a histocytological diagnosis in 72 (88.9%). The histological types were: adenocarcinomas in 37.5%; squamous in 33.3%; microcytic in 13.8%; undifferentiated non-small cell in 11.1%; large cell in 2.77%, and carcinoid in 1.38%. The most frequent treatments were chemotherapy (50.6%), symptomatic (23.4%), and surgery (12.3%). The incidence of lung cancer in Avila has decreased in both sexes in the last 10 years. In 2012, the patients have been older, the majority with adenocarcinoma histology, and receiving chemotherapy. Copyright © 2014 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España, S.L.U. All rights reserved.

Emergency peripartum hysterectomy, physical and mental consequences: a 6-year study

Directory of Open Access Journals (Sweden)

Denisa-Oana Bălălău

2016-04-01

Full Text Available Emergency peripartum hysterectomy (EPH is performed for massive postpartum hemorrhage following a cesarean delivery or vaginal delivery, in order to save the patient’s life. The current study was performed on a sample of 13.162 patients, which underwent cesarean or vaginal delivery during a period of 6 years, from 2010 to 2015, in Bucur Maternity Hospital. There were two subsequential groups consisting in: 6593 patients with cesarean operations and 6569 patients with vaginal delivery. In 12 cases occurred one or more of the risk factors that lead to EPH, divided equally across the two groups above. The main two types of surgery are a more frequent subtotal hysterectomy, which is the preferred type of EPH as it takes less time and is associated with fewer complications, and a total hysterectomy. The majority of procedures were performed at patients over 35 years old (9 of 12, with a median age of 31,16 (ranging from 21 to 44 years old. The most important risk factor present across the lot was multiparity (11 from 12, with cicatricial uterus being the second one (4 of 12. ICU median time was 4,5 days (ranging from 3 to 15 days, with a median blood transfusion necessity of around 2,4 I.U per patient. There were no mother or newborn reported deaths, neither PTSD following EPH.EPH is a procedure performed as last-resort, life-saving surgery, leaving no time for mental preparation of the patients. This may predispose to negative psychological outcomes, especially because they are not part of decision-making process due to the emergency character of hysterectomy.

Hysterectomy: a 12-year retrospective review in the Yaounde ...

African Journals Online (AJOL)

It is a retrospective review of all cases of hysterectomy over a 12-year period, from 1988 to 1999 inclusive. There were 183 cases of hysterectomy out of 1962 surgical operations giving an overall incidence of 9.33%. The mean age was 43.23 ± 8.53 years with a range of 15 to 65 years. Seven out of 111 (6.31%) women were ...

10-year evaluation of train accidents.

Science.gov (United States)

Akkaş, Meltem; Ay, Didem; Metin Aksu, Nalan; Günalp, Müge

2011-09-01

Although less frequent than automobile accidents, train accidents have a major impact on victims' lives. Records of patients older than 16 years of age admitted to the Adult Emergency Department of Hacettepe University Medical Center due to train accidents were retrospectively evaluated. 44 patients (30 males, 14 females) with a mean age of 31.8±11.4 years were included in the study. The majority of the accidents occurred during commuting hours. 37 patients were discharged, 22 of them from the emergency department. The mortality rate was 7/44 (16%). Overall mean Revised Trauma Score (RTS) was 10.5 (3 in deaths and 11.9 in survivors). In 5 patients, the cause of death was pelvic trauma leading to major vascular injury and lower limb amputation. In 1 patient, thorax and abdomen trauma and in 1 patient head injury were the causes of mortality. Primary risk factors for mortality were alcohol intoxication (100%), cardiopulmonary resuscitation on admittance (100%), recurrent suicide attempt (75%), presence of psychiatric illness (60%), and low RTS. In this study, most train accidents causing minor injuries were due to falling from the train prior to acceleration. Nevertheless, train accidents led to a mortality rate of 16% and morbidity rate of 37%. These findings draw attention to the importance of developing preventive strategies.

Search for an elusive 4.4-MeV α emitter in uranium minerals

International Nuclear Information System (INIS)

Dougan, R.J.; Illige, J.D.; Hulet, E.K.

1979-12-01

A search for an unidentified 4.4-MeV α-emitter in Belgian Congo pitchblende and uranium raffinates is described, and a history of observations of 4.4-MeV activity over the last 55 years in radiogenic haloes, zinc ores, monazite, thorite, huttonite, ultrabasic and other abyssal rocks, osmiridium, uranium ores, and raffinates of uranium is given. No evidence of excess 4.4-MeV activity was shown in any of the chemically separated fractions investigated. Upper limits for 4.4-MeV α activity in each of four studied samples are given

Use of propofol for anesthesia in cats with primary hepatic lipidosis: 44 cases (1995-2004).

Science.gov (United States)

Posner, Lysa P; Asakawa, Makoto; Erb, Hollis N

2008-06-15

OBJECTIVE-To determine morbidity and fatalities in cats with hepatic lipidosis that received propofol to facilitate placement of a feeding tube. STUDY DESIGN-Retrospective case series. ANIMALS-44 Cats with presumed primary hepatic lipidosis anesthetized for placement of a feeding tube. PROCEDURES-Medical records from January 1995 through December 2004 were reviewed to identify cats that matched the inclusion criteria (histologic confirmation of hepatic lipidosis, anesthetized for placement of feeding tube, complete intensive care unit [ICU] records, and recorded outcome). Data extracted included age, body weight, sex, anesthetic drugs, drug dosages, type of feeding tube, duration of anesthesia, number of hours in ICU, administration of blood products, and survival until discharge from ICU. RESULTS-44 Cats (21 females and 23 males) were included in the analysis. Age range was 3 to 15 years (median, 8 years), and body weight ranged from 1.8 to 9.0 kg (4.0 to 19.8 lb), with a median of 4.8 kg (10.6 lb). Twenty-seven cats were administered propofol. There was no significant association between the use of propofol or the dosage of propofol and any risk factor, need for blood products, number of hours in the ICU, or survival. There was no significant difference between cats that received propofol and cats that did not receive propofol with regard to interval until discharge from the ICU. CONCLUSIONS AND CLINICAL RELEVANCE-The use of propofol did not increase morbidity or fatalities in cats with primary hepatic lipidosis. Thus, propofol can be used in these cats for placement of a feeding tube.

44 CFR 6.22 - Accounting of disclosures.

Science.gov (United States)

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Accounting of disclosures. 6... Accounting of disclosures. (a) Except for disclosures made pursuant to § 6.20 (a) and (b), an accurate accounting of each disclosure shall be made and retained for 5 years after the disclosure or for the life of...

Fatal poisonings in Oslo: a one-year observational study.

Science.gov (United States)

Bjornaas, Mari A; Teige, Brita; Hovda, Knut E; Ekeberg, Oivind; Heyerdahl, Fridtjof; Jacobsen, Dag

2010-06-06

Acute poisonings are common and are treated at different levels of the health care system. Since most fatal poisonings occur outside hospital, these must be included when studying characteristics of such deaths. The pattern of toxic agents differs between fatal and non-fatal poisonings. By including all poisoning episodes, cause-fatality rates can be calculated. Fatal and non-fatal acute poisonings in subjects aged > or =16 years in Oslo (428 198 inhabitants) were included consecutively in an observational multi-centre study including the ambulance services, the Oslo Emergency Ward (outpatient clinic), and hospitals, as well as medico-legal autopsies from 1st April 2003 to 31st March 2004. Characteristics of fatal poisonings were examined, and a comparison of toxic agents was made between fatal and non-fatal acute poisoning. In Oslo, during the one-year period studied, 103 subjects aged > or =16 years died of acute poisoning. The annual mortality rate was 24 per 100 000. The male-female ratio was 2:1, and the mean age was 44 years (range 19-86 years). In 92 cases (89%), death occurred outside hospital. The main toxic agents were opiates or opioids (65% of cases), followed by ethanol (9%), tricyclic anti-depressants (TCAs) (4%), benzodiazepines (4%), and zopiclone (4%). Seventy-one (69%) were evaluated as accidental deaths and 32 (31%) as suicides. In 70% of all cases, and in 34% of suicides, the deceased was classified as drug or alcohol dependent. When compared with the 2981 non-fatal acute poisonings registered during the study period, the case fatality rate was 3% (95% C.I., 0.03-0.04). Methanol, TCAs, and antihistamines had the highest case fatality rates; 33% (95% C.I., 0.008-0.91), 14% (95% C.I., 0.04-0.33), and 10% (95% C.I., 0.02-0.27), respectively. Three per cent of all acute poisonings were fatal, and nine out of ten deaths by acute poisonings occurred outside hospital. Two-thirds were evaluated as accidental deaths. Although case fatality rates were

Maximum And Minimum Temperature Trends In Mexico For The Last 31 Years

Science.gov (United States)

Romero-Centeno, R.; Zavala-Hidalgo, J.; Allende Arandia, M. E.; Carrasco-Mijarez, N.; Calderon-Bustamante, O.

2013-05-01

Based on high-resolution (1') daily maps of the maximum and minimum temperatures in Mexico, an analysis of the last 31-year trends is performed. The maps were generated using all the available information from more than 5,000 stations of the Mexican Weather Service (Servicio Meteorológico Nacional, SMN) for the period 1979-2009, along with data from the North American Regional Reanalysis (NARR). The data processing procedure includes a quality control step, in order to eliminate erroneous daily data, and make use of a high-resolution digital elevation model (from GEBCO), the relationship between air temperature and elevation by means of the average environmental lapse rate, and interpolation algorithms (linear and inverse-distance weighting). Based on the monthly gridded maps for the mentioned period, the maximum and minimum temperature trends calculated by least-squares linear regression and their statistical significance are obtained and discussed.

New BV light curves of the eclipsing binary 44i Bootis

International Nuclear Information System (INIS)

Rovithis, P.; Rovithis-Livaniou, H.

1990-01-01

The eclipsing binary 44i Bootis, the fainter component of the visual binary ADS 9494, has been observed during 1980 as well as during 1988. The observations were made with the 48-inch Cassegrain reflector at the Kryonerion Station of the National Observatory of Athens, Greece. The individual observations of 44i Bootis are presented for years 1980 and 1988 and are also discussed. A linear as well as a quadratic least square fitting to the O-C diagram of 44i Boo for the last decade is given in which it is shown that the period of the system continues to increase

26 CFR 1.852-11 - Treatment of certain losses attributable to periods after October 31 of a taxable year.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Treatment of certain losses attributable to periods after October 31 of a taxable year. 1.852-11 Section 1.852-11 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Regulated Investment...

Kuppuswamy’s Socio-economic Status Scale: Updating Income Ranges for the Year 2015

Directory of Open Access Journals (Sweden)

Hema Thakkar

2015-12-01

Full Text Available Community and hospital based studies require assessment of socio-economic status of an individual/family. Socioeconomic status (SES is an important determinant of the health, nutritional status, mortality, and morbidity of an individual. SES also influences the accessibility, affordability, acceptability, and actual utilization of available health facilities. (1 There are many different scales to measure the SES of a family: Rahudkar scale 1960, Udai Parikh scale 1964, Jalota Scale 1970, Kulshrestha scale 1972, Kuppuswamy scale 1976, Shrivastava scale 1978, Bharadwaj scale 2001. (2,3,4,5,6,7,8 However, social transition and fast growing economy have reduced these scales effectiveness in measuring the SES over the years. Kuppuswamy’s socio-economic status scale is an important tool to measure socioeconomic status of families in urban areas. It was first proposed by Kuppuswamy in the in the year 1976. (6 (Table-1 This scale takes into account education, occupation of the head of the family and total income of the family per month from all the sources to categorise families into 5 groups; namely upper, upper middle, lower middle, upper lower and lower socioeconomic status. It is used by students and researchers in India for hospital and community based research. Mishra D and Singh HP (9 in their article on revision of Kuppuswamy’s Socio-economic status scale have pointed that an income scale usually has relevance only for the period under study. They further clarified that due to the steady inflation and consequent fall in the value of the rupee, the income criteria in the scale lose their relevance. There is an unprecedented demand from researchers for the updated version of this because changes in inflation rate change the monetary values of the monthly income range scores. Attempts to revise the original scale to bring the income subscale up to date are done by various authors. The year wise reference indices are shown in Table -2. It tell

Kuppuswamy’s Socio-economic Status Scale: Updating Income Ranges for the Year 2015

Directory of Open Access Journals (Sweden)

Hema Thakkar

2015-12-01

Full Text Available Community and hospital based studies require assessment of socio-economic status of an individual/family. Socioeconomic status (SES is an important determinant of the health, nutritional status, mortality, and morbidity of an individual. SES also influences the accessibility, affordability, acceptability, and actual utilization of available health facilities. (1There are many different scales to measure the SES of a family: Rahudkar scale 1960, Udai Parikh scale 1964, Jalota Scale 1970, Kulshrestha scale 1972, Kuppuswamy scale 1976, Shrivastava scale 1978, Bharadwaj scale 2001. (2,3,4,5,6,7,8 However, social transition and fast growing economy have reduced these scales effectiveness in measuring the SES over the years.Kuppuswamy’s socio-economic status scale is an important tool to measure socioeconomic status of families in urban areas. It was first proposed by Kuppuswamy in the in the year 1976. (6 (Table-1 This scale takes into account education, occupation of the head of the family and total income of the family per month from all the sources to categorise families into 5 groups; namely upper, upper middle, lower middle, upper lower and lower socioeconomic status. It is used by students and researchers in India for hospital and community based research. Mishra D and Singh HP (9 in their article on revision of Kuppuswamy’s Socio-economic status scale have pointed that an income scale usually has relevance only for the period under study. They further clarified that due to the steady inflation and consequent fall in the value of the rupee, the income criteria in the scale lose their relevance. There is an unprecedented demand from researchers for the updated version of this because changes in inflation rate change the monetary values of the monthly income range scores. Attempts to revise the original scale to bring the income subscale up to date are done by various authors.The year wise reference indices are shown in Table -2. It tell us

CD44v10, osteopontin and lymphoma growth retardation by a CD44v10-specific antibody.

Science.gov (United States)

Megaptche, Amelie Pajip; Erb, Ulrike; Büchler, Markus Wolfgang; Zöller, Margot

2014-09-01

Blockade of CD44 is considered a therapeutic option for the elimination of leukemia-initiating cells. However, the application of anti-panCD44 can be burdened by severe side effects. We determined whether these side effects could be avoided by replacing anti-panCD44 with CD44 variant isoform (CD44v)-specific antibodies in CD44v-positive hematological malignancies using the EL4 thymoma and CD44v10-transfected EL4 (EL4-v10) as models. Subcutaneous growth of EL4 and EL4-v10 was equally well inhibited by the anti-panCD44 and anti-CD44v10 antibodies, respectively. Ex vivo analysis indicated that natural killer cytotoxicity and antibody-dependent cellular cytotoxicity were the main effector mechanisms. Under local inflammation, the efficacy of anti-CD44v10 prolonged the survival time twofold compared with untreated, EL4-v10 tumor-bearing mice, and this was due to inflammation-induced expression of osteopontin (OPN). A high level of OPN in EL4-v10 tumors supported leukocyte recruitment and tumor-infiltrating T-cell activation. Taken together, in hematological malignancies expressing CD44v, anti-panCD44 can be replaced by CD44v-specific antibodies without a loss in efficacy. Furthermore, CD44v10-specific antibodies appear particularly advantageous in cutaneous leukemia therapy, as CD44v10 binding of OPN drives leukocyte recruitment and activation.

Towards biodiversity hotspots effective for conserving mammals with small geographic ranges

Science.gov (United States)

Carrara, Rodolfo; San Blas, Germán; Agrain, Federico; Roig-Juñent, Sergio

2017-01-01

The main goal of using global biodiversity hotspots for conservation purposes is to protect taxa with small geographic ranges because these are highly vulnerable to extinction. However, the extent to what different hotspots types are effective for meeting this goal remains controversial because hotspots have been previously defined as either the richest or most threatened and richest sites in terms of total, endemic or threatened species. In this regard, the use of species richness to set conservation priorities is widely discussed because strategies focused on this diversity measure tend to miss many of the taxa with small geographic ranges. Here we use data on global terrestrial mammal distributions to show that, hotspots of total species, endemism and threat defined in terms of species richness are effective in including 27%, 29% and 11% respectively, of the taxa with small geographic ranges. Whilst, the same hotspot types defined in terms of a simple diversity index, which is a function of species richness and range-size rarity, include 68%, 44% and 90% respectively, of these taxa. In addition, we demonstrate that index hotspot types are highly efficient because they conserve 79% of mammal species (21% more species than richness hotspot types), with 59% of species shared by three hotspot types (31% more than richness hotspot types). These results suggest that selection of different diversity measures to define hotspots may strongly affect the achievement of conservation goals.

Influence of Body Mass Index on Sagittal Knee Range of Motion and Gait Speed Recovery 1-Year After Total Knee Arthroplasty.

Science.gov (United States)

Bonnefoy-Mazure, Alice; Martz, Pierre; Armand, Stéphane; Sagawa, Yoshimasa; Suva, Domizio; Turcot, Katia; Miozzari, Hermes H; Lübbeke, Anne

2017-08-01

The purpose of this prospective study was to investigate the influence of body mass index (BMI) on gait parameters preoperatively and 1 year after total knee arthroplasty (TKA). Seventy-nine patients were evaluated before and 1 year after TKA using clinical gait analysis. The gait velocity, the knee range of motion (ROM) during gait, their gains (difference between baseline and 1 year after TKA), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), quality of life, and patient satisfaction were assessed. Nonobese (BMI gait speed and ROM gains. Adjustment was performed for gender, age, and WOMAC pain improvement. At baseline, gait velocity and knee ROM were significantly lower in obese compared with those in the nonobese patients (0.99 ± 0.27 m/s vs 1.11 ± 0.18 m/s; effect size, 0.53; P = .021; and ROM, 41.33° ± 9.6° vs 46.05° ± 8.39°; effect size, 0.52; P = .022). Univariate and multivariate linear regressions did not show any significant relation between gait speed gain or knee ROM gain and BMI. At baseline, obese patients were more symptomatic than nonobese (WOMAC pain: 36.1 ± 14.0 vs 50.4 ± 16.9; effect size, 0.9; P < .001), and their improvement was significantly higher (WOMAC pain gain, 44.5 vs 32.3; effect size, 0.59; P = .011). These findings show that all patients improved biomechanically and clinically, regardless of their BMI. Copyright © 2017 Elsevier Inc. All rights reserved.

Significance of CD44 expression in head and neck cancer: a systemic review and meta-analysis

International Nuclear Information System (INIS)

Chen, Jianqiang; Zhou, Jianding; Lu, Jie; Xiong, Hua; Shi, Xueli; Gong, Liang

2014-01-01

CD44 has been reported to be involved with tumor growth and metastasis and has also been implicated as a CSC marker in head and neck squamous cell cancer (HNSCC). However, the prognostic value of CD44 still remains controversial; hence, we investigated the correlation between CD44 and the clinicopathological features of HNSCC by meta-analysis. A comprehensive search was performed using PubMed, ISI web of Science and China National Knowledge Infrastructure (CNKI) up to April 2013. Only studies with immunohistochemical staining of HNSCC were considered. Data on TNM classification, tumor grade, disease free survival and 3- or 5-year overall survival rate were extracted. Thirty studies with 2102 patients met the inclusion criteria for the meta-analysis. Fifteen studies used anti-pan-CD44 antibody, 9 used anti-CD44-v6 antibody, 2 used anti-CD44-v3 and 2 used anti-CD44s antibody, 1 used anti-CD44-v9, and 1 used anti-CD44-v6,-v3 and -v4-5 simultaneously. The total percentage of CD44 expression was 57.8%, with 49.3% in oral cancer patients, 66.4% in pharynx and 54.7% in larynx cancer patients expressing CD44. No significant correlation between clinical features and CD44 expression was revealed for oral cancer patients, but CD44 was shown to be associated with advanced T categories (larynx: RR = 1.33, 95% CI 1.01-1.76; larynx & pharynx RR = 1.21, 95% CI 1.08-1.35), worse N categories (larynx: RR = 2.53, 95% CI 1.99-3.21; larynx & pharynx RR = 1.95, 95% CI 1.35-2.82), higher tumor grades (larynx & pharynx RR = 1.71, 95% CI 1.04-2.79) and 5-year OS rates (larynx: RR = 0.62, 95% CI 0.47-0.83; larynx & pharynx RR = 0.66, 95% CI 0.47-0.94) in patients with laryngeal and pharyngolaryngeal cancer. In stratified analysis, pan-CD44 and CD44-v6 expression were both correlated with 5-year OS rate of patients with laryngeal (CD44: RR = 0.66, 95% CI 0.46-0.95; CD44-v6 RR = 0.53, 95% CI 0.37-0.77) and pharyngolaryngeal cancer (CD44: RR = 0.56, 95% CI 0.34-0.93; CD44-v6 RR = 0.53, 95% CI

The severity of dental caries in adults aged 35 to 44 years residing in the metropolitan area of a large city in Brazil: a cross-sectional study.

Science.gov (United States)

Costa, Simone M; Vasconcelos, Mara; Haddad, João Paulo A; Abreu, Mauro Henrique N G

2012-07-31

In recent decades, studies in the field of public health have increasingly focused on social determinants that affect the health-illness process. The epidemiological perspective considers oral health to be a reflection of socioeconomic and environmental aspects, and it is particularly influenced by the social context. The aim of the present study was to assess the association between the severity of dental caries among adults aged 35 to 44 years and characteristics on the different levels at which the determinants of caries operate (individual, social structure and social context). A home-based, cross-sectional field study was carried out involving a sample of 1,150 adults (35 to 44 years of age) residing in metropolitan Belo Horizonte, Brazil. The DMFT (decayed, missing, filled tooth) index (≥14) was used to determine the severity of dental caries. Bivariate and multivariate analyses were carried out using the Poisson regression model with the level of significance set at 5% (p caries severity. The rate of high-severity caries in the group between 40 and 44 years of age was 1.15-fold (CI: 1.04-1.26) greater than that among those aged 35 to 39 years. A greater prevalence of high caries severity was found among those who frequently visited the dentist (PR = 1.18; CI: 1.07-1.30), those with a lower income (PR = 1.11; CI: 1.01-1.23), those who reported that their neighborhood did not come together in the previous year to petition political leaders for benefits (PR = 1.16; CI: 1.05-1.28) and those who are unable to make decisions (without empowerment) (PR = 1.12; CI: 1.01-1.24). The present study revealed high dental caries severity in adults, which was associated with individual characteristics, health-related behavior and social structure and contextual variables. These findings underscore the importance of considering social determinants involved in the health-illness process when carrying out epidemiological studies on dental caries.

NEUTRAL PION EMISSION FROM ACCELERATED PROTONS IN THE SUPERNOVA REMNANT W44

Energy Technology Data Exchange (ETDEWEB)

Giuliani, A.; Caraveo, P.; Chen, A.; Contessi, T. [INAF-IASF Milano, via E. Bassini 15, 20133 Milano (Italy); Cardillo, M.; Tavani, M.; Costa, E.; Monte, E. Del; Donnarumma, I.; Evangelista, Y.; Feroci, M. [INAF/IASF-Roma,via Del Fosso del Cavaliere 100, 00133 Roma (Italy); Fukui, Y.; Yoshiike, S.; Torii, K. [Department of Astrophysics, Nagoya University, Chikusa-ku, Nagoya 464-8602 (Japan); Dubner, G.; Castelletti, G. [Instituto de Astronomia y Fisica del Espacio (IAFE, CONICET-UBA), 1428 Buenos Aires (Argentina); Barbiellini, G. [Dipartimento di Fisica and INFN, Via Valerio 2, I-34127 Trieste (Italy); Bulgarelli, A.; Gianotti, F. [INAF/IASF-Bologna, Via Gobetti 101, I-40129 Bologna (Italy); Cattaneo, P. W. [INFN-Pavia, Via Bassi 6, I-27100 Pavia (Italy); and others

2011-12-15

We present the AGILE gamma-ray observations in the energy range 50 MeV-10 GeV of the supernova remnant (SNR) W44, one of the most interesting systems for studying cosmic-ray production. W44 is an intermediate-age SNR ({approx}20, 000 years) and its ejecta expand in a dense medium as shown by a prominent radio shell, nearby molecular clouds, and bright [S II] emitting regions. We extend our gamma-ray analysis to energies substantially lower than previous measurements which could not conclusively establish the nature of the radiation. We find that gamma-ray emission matches remarkably well both the position and shape of the inner SNR shocked plasma. Furthermore, the gamma-ray spectrum shows a prominent peak near 1 GeV with a clear decrement at energies below a few hundreds of MeV as expected from neutral pion decay. Here we demonstrate that (1) hadron-dominated models are consistent with all W44 multiwavelength constraints derived from radio, optical, X-ray, and gamma-ray observations; (2) ad hoc lepton-dominated models fail to explain simultaneously the well-constrained gamma-ray and radio spectra, and require a circumstellar density much larger than the value derived from observations; and (3) the hadron energy spectrum is well described by a power law (with index s = 3.0 {+-} 0.1) and a low-energy cut-off at E{sub c} = 6 {+-} 1 GeV. Direct evidence for pion emission is then established in an SNR for the first time.

Detection of high CD44 expression in oral cancers using the novel monoclonal antibody, C44Mab-5

Directory of Open Access Journals (Sweden)

Shinji Yamada

2018-07-01

Full Text Available CD44 is a transmembrane glycoprotein that regulates a variety of genes related to cell-adhesion, migration, proliferation, differentiation, and survival. A large number of alternative splicing isoforms of CD44, containing various combinations of alternative exons, have been reported. CD44 standard (CD44s, which lacks variant exons, is widely expressed on the surface of most tissues and all hematopoietic cells. In contrast, CD44 variant isoforms show tissue-specific expression patterns and have been extensively studied as both prognostic markers and therapeutic targets in cancer and other diseases. In this study, we immunized mice with CHO-K1 cell lines overexpressing CD44v3-10 to obtain novel anti-CD44 mAbs. One of the clones, C44Mab-5 (IgG1, kappa, recognized both CD44s and CD44v3-10. C44Mab-5 also reacted with oral cancer cells such as Ca9-22, HO-1-u-1, SAS, HSC-2, HSC-3, and HSC-4 using flow cytometry. Moreover, immunohistochemical analysis revealed that C44Mab-5 detected 166/182 (91.2% of oral cancers. These results suggest that the C44Mab-5 antibody may be useful for investigating the expression and function of CD44 in various cancers.

Detection of high CD44 expression in oral cancers using the novel monoclonal antibody, C44Mab-5.

Science.gov (United States)

Yamada, Shinji; Itai, Shunsuke; Nakamura, Takuro; Yanaka, Miyuki; Kaneko, Mika K; Kato, Yukinari

2018-07-01

CD44 is a transmembrane glycoprotein that regulates a variety of genes related to cell-adhesion, migration, proliferation, differentiation, and survival. A large number of alternative splicing isoforms of CD44, containing various combinations of alternative exons, have been reported. CD44 standard (CD44s), which lacks variant exons, is widely expressed on the surface of most tissues and all hematopoietic cells. In contrast, CD44 variant isoforms show tissue-specific expression patterns and have been extensively studied as both prognostic markers and therapeutic targets in cancer and other diseases. In this study, we immunized mice with CHO-K1 cell lines overexpressing CD44v3-10 to obtain novel anti-CD44 mAbs. One of the clones, C 44 Mab-5 (IgG 1 , kappa), recognized both CD44s and CD44v3-10. C 44 Mab-5 also reacted with oral cancer cells such as Ca9-22, HO-1-u-1, SAS, HSC-2, HSC-3, and HSC-4 using flow cytometry. Moreover, immunohistochemical analysis revealed that C 44 Mab-5 detected 166/182 (91.2%) of oral cancers. These results suggest that the C 44 Mab-5 antibody may be useful for investigating the expression and function of CD44 in various cancers.

48 CFR 44.307 - Reports.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Reports. 44.307 Section 44... SUBCONTRACTING POLICIES AND PROCEDURES Contractors' Purchasing Systems Reviews 44.307 Reports. The ACO shall distribute copies of CPSR reports; notifications granting, withholding, or withdrawing system approval; and...

Adoption experiences of women and men and demand for children to adopt by women 18-44 years of age in the United States, 2002.

Science.gov (United States)

Jones, Jo

2008-08-01

This report presents national estimates of the prevalence of adoption for men and women 18-44 years of age, the demand for children to adopt by women, and women's preferences for characteristics of the adopted child. Analysis is based on data from the 2002 National Survey of Family Growth. This survey interviewed a nationally representative sample of women and men 15-44 years of age in their households. Results are weighted to produce national estimates of the characteristics of men and women who have adopted children, lifetime and current demand for adoption by women, and the characteristics of children preferred by women when they are considering adoption. Adoption remains rare in the United States. Among all women aged 18-44 in 2002, only 1.1% had adopted a child and 1.6% were currently seeking to adopt. Women were more likely to be currently seeking to adopt, to have ever sought to adopt, and to have actually adopted a child if they had used infertility services or had impaired fecundity. Older women and women who were in their second or later marriage were also more likely to have adopted a child. Hispanic and non-Hispanic black women were more likely to be currently seeking to adopt compared with non-Hispanic white women. More men than women have adopted children in their lifetimes. Among adopters, 17% of women and 6% of men were never married. Adopting a child has been and remains a relatively rare event in the United States. Adoption is a mechanism by which adults legalize their parental relationship to nonbiological children as well as a means to bring children into families. Studies examining adoption should include men as well as women and persons of all marital statuses.

KINEMATICS OF OUTER HALO GLOBULAR CLUSTERS IN M31

International Nuclear Information System (INIS)

Veljanoski, J.; Ferguson, A. M. N.; Bernard, E. J.; Peñarrubia, J.; Mackey, A. D.; Huxor, A. P.; Irwin, M. J.; Chapman, S. C.; Côté, P.; Tanvir, N. R.; McConnachie, A.; Ibata, R. A.; Martin, N. F.; Fardal, M.; Lewis, G. F.

2013-01-01

We present the first kinematic analysis of the far outer halo globular cluster (GC) population in the Local Group galaxy M31. Our sample contains 53 objects with projected radii of ∼20-130 kpc, 44 of which have no previous spectroscopic information. GCs with projected radii ∼> 30 kpc are found to exhibit net rotation around the minor axis of M31, in the same sense as the inner GCs, albeit with a smaller amplitude of 79 ± 19 km s –1 . The rotation-corrected velocity dispersion of the full halo GC sample is 106 ± 12 km s –1 , which we observe to decrease with increasing projected radius. We find compelling evidence for kinematic coherence among GCs that project on top of halo substructure, including a clear signature of infall for GCs lying along the northwest stream. Using the tracer mass estimator, we estimate the dynamical mass of M31 within 200 kpc to be M M31 = (1.2-1.5) ± 0.2 × 10 12 M ☉ . This value is highly dependent on the chosen model and assumptions within.

Radiolabeling of DOTATOC with the long-lived positron emitter {sup 44}Sc

Energy Technology Data Exchange (ETDEWEB)

Pruszynski, Marek; Majkowska-Pilip, Agnieszka [Centre of Radiochemistry and Nuclear Chemistry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warszawa (Poland); Loktionova, Natalia S.; Eppard, Elisabeth [Institute of Nuclear Chemistry, Johannes Gutenberg-University of Mainz, Fritz-Strassmann-Weg 2, D-55128 Mainz (Germany); Roesch, Frank, E-mail: frank.roesch@uni-mainz.de [Institute of Nuclear Chemistry, Johannes Gutenberg-University of Mainz, Fritz-Strassmann-Weg 2, D-55128 Mainz (Germany)

2012-06-15

The positron-emitting radionuclide {sup 44}Sc with a half-life of 3.97 h and a {beta}{sup +} branching of 94.3% is of potential interest for clinical PET. As so far it is available from a {sup 44}Ti/{sup 44}Sc generator in Mainz, where long-lived {sup 44}Ti decays to no-carrier-added (nca) {sup 44}Sc. The {sup 44}Sc is a trivalent metal cation and should be suitable for complexation with many well established bifunctional chelators conjugated to peptides or other molecular targeting vectors. Thus, the aim of this work was to investigate the potential of {sup 44}Sc for labeling of DOTA-conjugated peptides. DOTA-D-Phe{sup 1}-Tyr{sup 3}-octreotide (DOTATOC) was used as a model molecule to study and optimize labeling procedure. Reaction parameters such as buffer conditions, concentration of peptide, pH range, reaction temperature and time were optimized. Addition of 21 nmol of DOTATOC to {sup 44}Sc in ammonium acetate buffer pH 4.0 provided labeling yields >98% within 25 min of heating in an oil-bath at 95 Degree-Sign C. This time can be reduced to 3 min only by applying microwave supported heating. {sup 44}Sc-DOTATOC was found to be stable in 0.9% NaCl, PBS pH 7.4, fetal calf and human serums, and also in the presence of competing metal cations (Fe{sup 3+}, Ca{sup 2+}, Cu{sup 2+}, Mg{sup 2+}), as well as other ligand competitors, like EDTA and DTPA, even after almost 25 h incubation at 37 Degree-Sign C. Present study shows that nca {sup 44}Sc forms stable complexes with the macrocyclic ligand DOTA and that {sup 44}Sc-DOTATOC and analog targeting vectors may be synthesized for further preclinical and clinical investigations. - Highlights: Black-Right-Pointing-Pointer Labeling of somatostatin analouges with positron emitter {sup 44}Sc was tested. Black-Right-Pointing-Pointer DOTATOC was labeled with {sup 44}Sc isotope. Black-Right-Pointing-Pointer Optimal conditions for {sup 44}Sc-DOTATOC synthesis were found. Black-Right-Pointing-Pointer Stability of {sup 44}Sc

POST-CLOSURE INSPECTION REPORT FOR THE TONOPAH TEST RANGE, NEVADA FOR CALENDAR YEAR 2005

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-06-01

This post-closure inspection report includes the results of inspections, maintenance and repair activities, and conclusions and recommendations for Calendar Year 2005 for nine Corrective Action Units located on the Tonopah Test Range , Nevada.

26 CFR 1.907(c)-2 - Section 907(c)(3) items (for taxable years beginning after December 31, 1982).

Science.gov (United States)

2010-04-01

... United States § 1.907(c)-2 Section 907(c)(3) items (for taxable years beginning after December 31, 1982...). Except as otherwise provided in this paragraph (b)(1), gain (or loss) from the disposition of stock in... dividend × a/b a = FORI accumulated profits in excess of FORI taxes paid or accrued, and b = Total...

Analytical determination of specific 4,4'-methylene diphenyl diisocyanate hemoglobin adducts in human blood.

Science.gov (United States)

Gries, Wolfgang; Leng, Gabriele

2013-09-01

4,4'-Methylene diphenyl diisocyanate (MDI) is one of the most important isocyanates in the industrial production of polyurethane and other MDI-based synthetics. Because of its high reactivity, it is known as a sensitizing agent, caused by protein adducts. Analysis of MDI is routinely done by determination of the nonspecific 4,4'-methylenedianiline as a marker for MDI exposure in urine and blood. Since several publications have reported specific adducts of MDI and albumin or hemoglobin, more information about their existence in humans is necessary. Specific adducts of MDI and hemoglobin were only reported in rats after high-dose MDI inhalation. The aim of this investigation was to detect the hemoglobin adduct 5-isopropyl-3-[4-(4-aminobenzyl)phenyl]hydantoin (ABP-Val-Hyd) in human blood for the first time. We found values up to 5.2 ng ABP-Val-Hyd/g globin (16 pmol/g) in blood samples of workers exposed to MDI. Because there was no information available about possible amounts of this specific MDI marker, the analytical method focused on optimal sensitivity and selectivity. Using gas chromatography-high-resolution mass spectrometry with negative chemical ionization, we achieved a detection limit of 0.02 ng ABP-Val-Hyd/g globin (0.062 pmol/g). The robustness of the method was confirmed by relative standard deviations between 3.0 and 9.8 %. Combined with a linear detection range up to 10 ng ABP-Val-Hyd/g globin (31 pmol/g), the enhanced precision parameter demonstrates that the method described is optimized for screening studies of the human population.

12 CFR 561.44 - Security.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Security. 561.44 Section 561.44 Banks and... SAVINGS ASSOCIATIONS § 561.44 Security. The term security means any non-withdrawable account, note, stock... commonly known as a security, or any certificate of interest or participation in, temporary or interim...

28 CFR 44.303 - Determination.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Determination. 44.303 Section 44.303... Enforcement Procedures § 44.303 Determination. (a) Within 120 days of the receipt of a charge, the Special... the end of the 120-day period, the Special Counsel shall issue letters of determination by certified...

Wind energy use in Germany. Status 31.12.2012; Windenergienutzung in Deutschland. Stand 31.12.2012

Energy Technology Data Exchange (ETDEWEB)

Ender, C. [DEWI GmbH, Wilhelmshaven (Germany)

2013-02-15

2012 has been a good year for the development of wind energy world-wide and also for Germany. All in all, the global installed wind power capacity in 2012 was 44,712 MW, which is an increase of 8.4 % compared to last year's figures (Tab. 1). Of the new installations, about 59 per cent were realized in China (13.2 GW) and the USA (13.1 GW), followed by Germany and India. It is interesting to note that for the first time Romania has made it among the TOP 10 countries in 2012. With 923 MW new installed capacity the country achieved the tenth position. [1] The positive market development for Germany was already foreseeable when evaluating the figures for the first six months of 2012, and it was confirmed at the end of the year. Based on the average share of the first half year in the annual result over the last five years, new installations of up to 2,350 MW could be expected. The final installation figures of 2,440 MW even exceeded the forecast. This result is the fourth best in the history of the DEWI-Statistics, only beaten by the installations of the record years 2001 to 2003. The good result is probably partly due to projects promoted because of the Energiewende, but also to repowering projects which are contributing an increasing share in the wind energy development. Older wind turbines from the 1990s have now reached an age where replacement may be considered. This applies especially to turbines that were erected after 1998 and are located in wind priority areas. In concrete figures, according to information supplied by wind turbine manufacturers1 altogether 1,003 new wind turbines (WTGS) with 2,439.66 megawatt (MW) were installed in Germany in 2012 (Fig. 1). This means an increase of 21.5 % compared to the year before. As already mentioned, repowering projects have made a significant contribution to the development. Their share in the new installations is approx. 22 %, plus the use of repowering bonus certificates for 117 dismantled wind turbines. Apart

Functional Differences between Human NKp44(-) and NKp44(+) RORC(+) Innate Lymphoid Cells.

Science.gov (United States)

Hoorweg, Kerim; Peters, Charlotte P; Cornelissen, Ferry; Aparicio-Domingo, Patricia; Papazian, Natalie; Kazemier, Geert; Mjösberg, Jenny M; Spits, Hergen; Cupedo, Tom

2012-01-01

Human RORC(+) lymphoid tissue inducer cells are part of a rapidly expanding family of innate lymphoid cells (ILC) that participate in innate and adaptive immune responses as well as in lymphoid tissue (re) modeling. The assessment of a potential role for innate lymphocyte-derived cytokines in human homeostasis and disease is hampered by a poor characterization of RORC(+) innate cell subsets and a lack of knowledge on the distribution of these cells in adults. Here we show that functionally distinct subsets of human RORC(+) innate lymphoid cells are enriched for secretion of IL-17a or IL-22. Both subsets have an activated phenotype and can be distinguished based on the presence or absence of the natural cytotoxicity receptor NKp44. NKp44(+) IL-22 producing cells are present in tonsils while NKp44(-) IL-17a producing cells are present in fetal developing lymph nodes. Development of human intestinal NKp44(+) ILC is a programmed event that is independent of bacterial colonization and these cells colonize the fetal intestine during the first trimester. In the adult intestine, NKp44(+) ILC are the main ILC subset producing IL-22. NKp44(-) ILC remain present throughout adulthood in peripheral non-inflamed lymph nodes as resting, non-cytokine producing cells. However, upon stimulation lymph node ILC can swiftly initiate cytokine transcription suggesting that secondary human lymphoid organs may function as a reservoir for innate lymphoid cells capable of participating in inflammatory responses.

40 CFR 31.26 - Non-Federal audit.

Science.gov (United States)

2010-07-01

... awards in a fiscal year, shall: (1) Determine whether State or local subgrantees have met the audit... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Non-Federal audit. 31.26 Section 31.26... Requirements Financial Administration § 31.26 Non-Federal audit. (a) Basic rule. Grantees and subgrantees are...

78 FR 20299 - National Institute on Disability and Rehabilitation Research; Long-Range Plan for Fiscal Years...

Science.gov (United States)

2013-04-04

... well-designed research and development activities using a range of appropriate methods. Adopt stages-of... year as they conduct independent research projects. Small Business Innovation Research (SBIR) grants... research and development activities using a range of appropriate methods. Objective 2.1--Adopt a stages-of...

19 CFR 148.44 - Gifts.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 2 2010-04-01 2010-04-01 false Gifts. 148.44 Section 148.44 Customs Duties U.S...) PERSONAL DECLARATIONS AND EXEMPTIONS Exemptions for Nonresidents § 148.44 Gifts. (a) Exemption. An arriving... and are to be disposed of by him as bona fide gifts. See § 148.43(b) for limitations on cigars under...

20-year LiDAR observations of stratospheric sudden warming over a mid-latitude site, Observatoire de Haute Provence (44°N, 6°E): Case study and statistical characteristics

CSIR Research Space (South Africa)

Charyulu, DV

2007-11-01

Full Text Available The present study delineates the characteristics of Stratospheric Sudden Warming (SSW) events observed over the Observatoire de Haute Provence (OHP: 44°N, 6°E). The study uses 20 years of Rayleigh LiDAR temperature measurements for the 1982...

Electronic and vibrational signatures of the Au102(p-MBA)44 cluster.

Science.gov (United States)

Hulkko, Eero; Lopez-Acevedo, Olga; Koivisto, Jaakko; Levi-Kalisman, Yael; Kornberg, Roger D; Pettersson, Mika; Häkkinen, Hannu

2011-03-23

Optical absorption of a gold nanocluster of 102 Au atoms protected by 44 para-mercaptobenzoic acid (p-MBA) ligands is measured in the range of 0.05-6.2 eV (mid-IR to UV) by a combination of several techniques for purified samples in solid and solution phases. The results are compared to calculations for a model cluster Au(102)(SMe)(44) based on the time-dependent density functional theory in the linear-response regime and using the known structure of Au(102)(p-MBA)(44). The measured and calculated molar absorption coefficients in the NIR-vis region are comparable, within a factor of 2, in the absolute scale. Several characteristic features are observed in the absorption in the range of 1.5-3.5 eV. The onset of the electronic transitions in the mid-IR region is experimentally observed at 0.45 ± 0.05 eV which compares well with the lowest calculated transition at 0.55 eV. Vibrations in the ligand layer give rise to fingerprint IR features below the onset of low-energy metal-to-metal electronic transitions. Partial exchange of the p-MBA ligand to glutathione does not affect the onset of the electronic transitions, which indicates that the metal core of the cluster is not affected by the ligand exchange. The full spectroscopic characterization of the Au(102)(p-MBA)(44) reported here for the first time gives benchmarks for further studies of manipulation and functionalization of this nanocluster to various applications.

Comparative study of joint range of motion in children between 7 and 12 years of age from different gender

Directory of Open Access Journals (Sweden)

S.I.L. Melo

2011-01-01

Full Text Available The aim of the study was to evaluate and compare active and passive joint range of motion in children in relation to gender and age. This study involved 103 children (43 boys and 60 girls categorized into two groups: G1 (7 to 9 years old and G2 (10 to 12 years old. The flexitest protocol, active and passive, and the SAPO® were used to evaluate joint range of motion. A paired t test was applied to compare active and passive joint range of motion and an independent t test (p < .05 was used to compare active and passive range of motion between gender and age. Results showed that the passive joint ranges of motion of the lower limbs are higher than active motion (p < .001. Girls presented greater passive ankle flexion than boys did (p = .002. Children between 7 and 12 years of age presented similar standards of joint range of motion of low limb. Significant differences were found between passive and active angular range of motion in the hip, knee and ankle. There were no differences between boys and girls in the joint range of motion as well as among age groups.

Excitation functions of the {sup nat}Cr(p,x){sup 44}Ti, {sup 56}Fe(p,x){sup 44}Ti, {sup nat}Ni(p,x){sup 44}Ti and {sup 93}Nb(p,x){sup 44}Ti reactions at energies up to 2.6 GeV

Energy Technology Data Exchange (ETDEWEB)

Titarenko, Yu. E.; Batyaev, V.F.; Pavlov, K.V.; Titarenko, A. Yu. [National Research Center Kurchatov Institute, Institute for Theoretical and Experimental Physics, Moscow 117218 (Russian Federation); Zhivun, V.M. [National Research Center Kurchatov Institute, Institute for Theoretical and Experimental Physics, Moscow 117218 (Russian Federation); National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow 115409 (Russian Federation); Chauzova, M.V.; Balyuk, S.A.; Bebenin, P.V. [National Research Center Kurchatov Institute, Institute for Theoretical and Experimental Physics, Moscow 117218 (Russian Federation); Ignatyuk, A.V. [National Research Center Kurchatov Institute, Institute for Theoretical and Experimental Physics, Moscow 117218 (Russian Federation); Institute of Physics and Power Engineering, Obninsk 249033 (Russian Federation); Mashnik, S.G. [Los Alamos National Laboratory (United States); Leray, S.; Boudard, A.; David, J.C.; Mancusi, D. [CEA/Saclay, Irfu/SPhN, 91191 Gif-sur-Yvette, Cedex (France); Cugnon, J. [University of Liege (Belgium); Yariv, Y. [SoreqNRC, Yavne (Israel); Nishihara, K.; Matsuda, N. [JAEA, Tokai (Japan); Kumawat, H. [BARC, Mumbai (India); Stankovskiy, A. Yu. [SCK-CEN (Belgium)

2016-06-11

The paper presents the measured cumulative yields of {sup 44}Ti for {sup nat}Cr, {sup 56}Fe, {sup nat}Ni and {sup 93}Nb samples irradiated by protons at the energy range 0.04–2.6 GeV. The obtained excitation functions are compared with calculations of the well-known codes: ISABEL, Bertini, INCL4.2+ABLA, INCL4.5+ABLA07, PHITS, CASCADE07 and CEM03.02. The predictive power of these codes regarding the studied nuclides is analyzed.

From morbid obesity to a healthy weight using cognitive-behavioral methods: a woman's three-year process with one and one-half years of weight maintenance.

Science.gov (United States)

Annesi, James J; Tennant, Gisèle A

2012-01-01

Obesity is a national health problem regularly confronting medical professionals. Although reduced-energy (kilocalorie [kcal]) eating and increased exercise will reliably reduce weight, these behaviors have been highly resistant to sustained change. To control eating using theory-based cognitive-behavioral methods that leverage the positive psychosocial effects of newly initiated exercise as an alternate to typical approaches of education about appropriate nutrition. A woman, age 48 years, with morbid obesity initiated exercise through a 6-month exercise support protocol based on social cognitive and self-efficacy theory (The Coach Approach). This program was followed by periodic individual meetings with a wellness professional intended to transfer behavioral skills learned to adapt to regular exercise, to then control eating. There was consistent recording of exercises completed, foods consumed, various psychosocial and lifestyle factors, and weight. Over the 4.4 years reported, weight decreased from 117.6 kg to 59.0 kg, and body mass index (BMI) decreased from 43.1 kg/m(2) to 21.6 kg/m(2). Mean energy intake initially decreased to 1792 kcal/day and further dropped to 1453 kcal/day by the end of the weight-loss phase. Consistent with theory, use of self-regulatory skills, self-efficacy, and overall mood significantly predicted both increased exercise and decreased energy intake. Morbid obesity was reduced to a healthy weight within 3.1 years, and weight was maintained in the healthy range through the present (1.3 years later). This case supports theory-based propositions that exercise-induced changes in self-regulation, self-efficacy, and mood transfer to and reinforce improvements in corresponding psychosocial factors related to controlled eating.

The Manitoba Hydro-Electric Board, 41st annual report for the year ended March 31, 1992

International Nuclear Information System (INIS)

1992-01-01

A report is presented of the year's activities of the corporation responsible for supplying electric power to Manitoba. The corporation serves all areas of the province except central Winnipeg, and it operates 12 hydraulic generating stations, 2 thermal generating stations and 12 diesel sites. Combined generation and imports totalled 25 billion kWh, of which 23.6 kWh was produced from hydraulic stations. The various sections of the report present information on customer services; electricity generated, purchased, and exported; system development, including construction of new power plants; research and development; environmental services; personnel policies; and water management. Financial statements are also provided. Highlights of the year include: a net income of $17.7 million for the year ending 31 March 1992; the official opening of the Limestone generating station; the shutdown of the Grand Rapids generating station due to headcover failure; official launch of the Power Smart program; targeted reduction in load growth of 285 million MW; and conclusion of settlements with the Pas indian band, the community of Cormorant and the Grand Rapids First Nation. 8 figs

Reappraisal of the role of endobronchial brachytherapy in the management of lung cancer: 10 years' experience at the centre Antoine-Lacassagne

International Nuclear Information System (INIS)

Magne, N.; Benezery, K.; Marcie, S.; Lagrange, J.L.; Porsin, B.; Poudenx, M.; Otto, J.; Marcy, P.Y.; Benezery, K.; Lagrange, J.L.

2003-01-01

Intra-operative interstitial brachytherapy has been applied in the curative and palliative treatment of lung cancer. Implantation of radio-active sources offers an advantage over external irradiation because of the limited penetrability from source to prescription point, resulting in rapid dose fall-off and sparing of surrounding normal tissues. The aim of this study was to re-evaluate retrospectively the Antoine-Lacassagne cancer center experience in endobronchial brachytherapy by low dose rate (LDR) or high dose rate (HDR) and to design perspectives for the next decades. Evaluation was based on analysis of toxicities, response rates and survival. Materials and methods: From october 1989 to june 1999, 31 consecutive patients with bronchogenic carcinoma were treated. Thirteen and 18 patients received LDR and HDR, respectively. The mean age was 65 years (range 44 to 79 years). Inclusion criteria were, for palliative treatment, incurable endobronchial cancer, and for curative treatment, residual tumor in the margins after resection, or endobronchial tumor could not be treated surgically. Exclusion criteria were sites of lesion unsuitable for placement of the brachytherapy catheter. Evaluation of complications and clinical response were based on endoscopic evaluation one month after the last session and at less one year after the end of treatment. Eighty-seven courses have been performed: 65 by LDR and 22 by HDR. Thirty-six courses have been performed in the palliative group, 51 courses in the curative group. Seven patients among 31 presented acute complications and 18/31 late complications. Complete global response rate was 14/30 evaluable patients (47%). Mean overall Global survival was 23 months with a median follow-up of 3.5 years. These results confirm the efficacy of endobronchial brachytherapy as well as palliative or curative treatment, but the improvement of results will essentially depend on our capacity to better define our indications and underlie the

4,4′-Bipyridinium bis(perchlorate–4-aminobenzoic acid–4,4′-bipyridine–water (1/4/2/2

Directory of Open Access Journals (Sweden)

Qun-Hui Meng

2009-01-01

Full Text Available In the structure of the title compound, C10H10N22+·2ClO4−·4C7H7NO2·2C10H8N2·2H2O, the 4,4′-bipyridinium cation has a crystallographically imposed centre of symmetry. The cation is linked by N—H...N hydrogen bonds to adjacent 4,4′-bipyridine molecules, which in turn interact via O—H...N hydrogen bonds with 4-aminobenzoic acid molecules, forming chains running parallel to [30overline{2}]. The chains are further connected into a three-dimensional network by N—H...O and O—H...O hydrogen-bonding interactions involving the perchlorate anion, the water molecules and the 4-aminobenzoic acid molecules. In addition, π–π stacking interactions with centroid–centroid distances ranging from 3.663 (6 to 3.695 (6 Å are present. The O atoms of the perchlorate anion are disordered over two sets of positions, with refined site occupancies of 0.724 (9 and 0.276 (9.

Two dimensional untwisted (4,4), twisted (4,4-bar) and chiral supersymmetric non linear σ-models

International Nuclear Information System (INIS)

Lhallabi, T.; Saidi, E.H.

1987-09-01

D=2 N=(4,4) harmonic superspace analysis is developed. The underlying untwisted (4,4) non linear σ-models are studied. A method of deriving chiral (4,0) and (0,4) models is presented. The Lagrange superparameter leading to the constraint specifying the hyperkahler manifold structure is predicted and its relation to the matter superfield is stated in a covariant way. A known construction is recovered. We show also that (4,4) model is not a direct sum of the chiral ones. Finally a twisted (4,4-bar) model is obtained. (author). 28 refs

Impact of new healthcare legislation and price policy on healthcare services provider at the time of financial crisis. A 10 years study

Directory of Open Access Journals (Sweden)

Ivona Malovecka

2015-03-01

Full Text Available Monitoring, calculation and assessment of healthcare services prosperity in the community pharmacy with the help of financial analysis indicators for the years 2003-2012, using financial statements was conducted, with respect to profitability, debt, liquidity, working capital, and efficiency parameters. These ratios reflect various changes that hold between years 2003 and 2012. Under the time of financial crisis, recession and serious socio-economic changes the profitability parameter Gross Profit ranged from 2003-2011 = 16.12-22.79% (average = 19.20%; mean = 19.78%; σ = 2.41, but in 2012 decreased on 14.35%. Net Profit ranged 2003-2011 = 10.96-18.3% (average = 14.62%; mean = 16.62%; σ = 4.92, while in 2012 reached only 2.29%. Debt ratio ranged from 2003-2012= 2.33-4.81 (average = 3.44; mean = 3.07; σ = 0.82. Liquidity parameters Current Ratio spread between 2003-2012 = 1.13-1.71 (average = 1.43; mean = 1.46; σ = 0.15 and Quick Ratio spread between 2003-2012 = 0.72-1.27 (average = 1.07; mean = 1.09; σ = 0.15. Working Capital Ratio ranged from 2003-2012 = 2.66-12.94 (average = 9.58; mean = 10.06; σ = 3.1 and efficiency ratios were measured either. All changes that have taken place in the society had an impact on community pharmacy finance by worsening its profitability, liquidity, working capital and some of efficiency parameters. Therefore the stability of community pharmacy may be threatened and may affect its future performance.http://dx.doi.org/10.7175/fe.v16i1.1040

Iliococcygeus fixation for the treatment of apical vaginal prolapse: efficacy and safety at 5 years of follow-up.

Science.gov (United States)

Serati, Maurizio; Braga, Andrea; Bogani, Giorgio; Leone Roberti Maggiore, Umberto; Sorice, Paola; Ghezzi, Fabio; Salvatore, Stefano

2015-07-01

Sacrocolpopexy is considered the gold standard treatment for vaginal vault prolapse. However, the vaginal approach is very common, with 80-90 % of procedures being performed via this route. The aim of this study was to evaluate the safety and efficacy of iliococcygeus (ICG) fixation in the treatment of vaginal vault prolapse, with a minimum follow-up of 5 years. We prospectively enrolled women with symptomatic vaginal vault prolapse (Pelvic Organ Prolapse Quantification [POP-Q] stage ≥2) who were treated with ICG fixation. Subjective success was defined in the case of Patient Global Impression of Improvement ≤ 2 and an absence of bulging symptoms. Objective success was defined as stage of prolapse < 2 in all compartments. Overall success rate was defined as women without prolapse symptoms, PGI-I ≤ 2, stage of prolapse < 2, and no need for other surgery. All women filled in the Prolapse Quality of Life (P-QOL) questionnaire both at the preoperative visit and at every follow-up visit. Multiple logistic regression was performed to identify factors involved in the risk of recurrent POP. After a median (range) follow-up of 68.8 (60-92) months the subjective, objective, and overall cure rates were 88.6 % (39 out of 44), 84.1 % (37 out of 44), and 84.1 % (37 out of 44) respectively. Only preoperative stage IV vault descensus independently predicted POP recurrence after iliococcygeus fixation (OR: 8.78 [95 % CI: 1.31-9.42]; p < 0.001). Iliococcygeus fixation is a safe and effective surgical technique for the treatment of vaginal vault prolapse with long-lasting effectiveness.

Nosocomial bloodstream infection in a neonatal intensive care unit of a medical center: a three-year review.

Science.gov (United States)

Tseng, Ya-Chun; Chiu, Yu-Chiao; Wang, Jen-Hsien; Lin, Hsiao-Chuan; Lin, Hung-Chih; Su, Bai-Horng; Chiu, Hsiu-Hui

2002-09-01

Bloodstream infections are the most frequent nosocomial infections in neonatal intensive care units. This retrospective study surveyed the epidemiologic characteristics of nosocomial bloodstream infections which occurred in the neonatal intensive care unit from January 1, 1997 to December 31, 1999. The overall infection patient rate was 5.5% in the 3-year period, and the overall infection patient-day rate was 4.4 per 1000 patient-days. Low birth weight was a risk factor for bloodstream infections. The rate of infection for neonates with birth weight below 1000 g ranged from 36.6% to 45.8% (1997: 36.6%; 1998: 45.8% and 1999: 38.9%). The most common pathogens causing nosocomial bloodstream infection were: Staphylococcus aureus (18.5%) (with 92% oxacillin-resistant), Acinectobacter baumannii (16.3%), Klebsiella pneumoniae (11.9%), Escherichia coli (9.6%), and Pseudomonas aeruginosa (8.1%). The mortality due to nosocomial bloodstream infection was highest among gram-negative bacteria, especially with P. aeruginosa (45.5%). Therefore, surveillance of nosocomial bloodstream infection and successful strategies to decrease nosocomial bloodstream infection, such as infection control and optimal antibiotic use, are warranted.

26 CFR 44.0-1 - Introduction.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 16 2010-04-01 2010-04-01 true Introduction. 44.0-1 Section 44.0-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) MISCELLANEOUS EXCISE TAXES TAXES ON WAGERING; EFFECTIVE JANUARY 1, 1955 Introduction § 44.0-1 Introduction. (a) In general. The...

40 CFR 61.44 - Stack sampling.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 8 2010-07-01 2010-07-01 false Stack sampling. 61.44 Section 61.44 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Firing § 61.44 Stack sampling. (a) Sources subject to § 61.42(b) shall be continuously sampled, during...

7 CFR 930.44 - Quality control.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Quality control. 930.44 Section 930.44 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Control § 930.44 Quality control. (a) Quality standards. The Board may establish, with the approval of the...

18 CFR 420.44 - Cooling water.

Science.gov (United States)

2010-04-01

... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Cooling water. 420.44 Section 420.44 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL BASIN REGULATIONS-WATER SUPPLY CHARGES Charges; Exemptions § 420.44 Cooling water. Water used...

Relationships among range of motion, functional mobility, and quality of life in children and adolescents after limb-sparing surgery for lower-extremity sarcoma.

Science.gov (United States)

Marchese, Victoria G; Spearing, Elena; Callaway, Lulie; Rai, Shesh N; Zhang, Lijun; Hinds, Pamela S; Carlson, Claire A; Neel, Michael D; Rao, Bhaskar N; Ginsberg, Jill

2006-01-01

The study was designed to examine relationships between range of motion (ROM), functional mobility, and quality of life (QL) in patients with lower-extremity sarcoma (LES) after limb-sparing surgery Sixty-eight patients with LES (age, 10-26 years) participated. The patients performed hip flexion, hip extension, knee flexion, and knee extension, Timed Up and Down Stairs (TUDS), Timed Up and Go (TUG), nine-minute run-walk (9-min), and completed the QL measure, Short-Form-36 version two (SF-36v2). Significant correlations (p < 0.01) were found between hip extension and SF-36v2 physical component scale (PCS; r = 0.33), TUDS (r = -0.32), TUG (r = -0.33); hip flexion and TUDS (r = -0.31), TUG (r = -0.39), 9-min (r = 0.44); knee flexion and TUDS (r = -0.52), TUG (r = -0.40), 9-min (r = 0.37); SF-36v2 PCS and TUDS (r = -0.56), TUG (r = -0.51), 9-min (r = 0.60). ROM correlates with functional mobility and QL in patients with LES after limb-sparing surgery. ROM exercises are important component of a physical therapy program for children and adolescents with LES.

27 CFR 44.254 - Shipping containers.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Shipping containers. 44.254 Section 44.254 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... Requirements § 44.254 Shipping containers. Each shipping case, crate, or other container, in which cigars are...

34 CFR 300.44 - Universal design.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Universal design. 300.44 Section 300.44 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES General Definitions Used in This Part § 300.44 Universal design. Universal design has the meaning...

29 CFR 44.3 - Election process.

Science.gov (United States)

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true Election process. 44.3 Section 44.3 Labor Office of the Secretary of Labor PROCESS FOR ELECTING STATE AGENCY EMPLOYMENT STATISTICS REPRESENTATIVES FOR CONSULTATIONS WITH DEPARTMENT OF LABOR § 44.3 Election process. (a) Process. The Commissioner of Labor Statistics of...

27 CFR 478.44 - Original license.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Original license. 478.44 Section 478.44 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND....44 Original license. (a)(1) Any person who intends to engage in business as a firearms or ammunition...

30 CFR 256.44 - Bids disqualified.

Science.gov (United States)

2010-07-01

... by law, regulation, lease or stipulation to lease shall not disqualify an otherwise qualified bid; or... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Bids disqualified. 256.44 Section 256.44... OIL AND GAS IN THE OUTER CONTINENTAL SHELF Issuance of Leases § 256.44 Bids disqualified. The...

Department of Veterans Affairs Quarterly Notice to Congress on Data Breaches First Quarter of Fiscal Year 2014 October 1, 2013 through December 31, 2013

Data.gov (United States)

Department of Veterans Affairs — This is a quarterly notice to congress containing statistics on data breeches for fiscal year 2014 for the first quarter (2014 October 1, 2013 through December 31,...

40 CFR 86.097-9 - Emission standards for 1997 and later model year light-duty trucks.

Science.gov (United States)

2010-07-01

...-3750 0.25 3.4 0.4 0.08 Natural Gas 3751-5750 0.32 4.4 0.7 0.08 LPG 0-3750 0.25 3.4 0.4 0.08 LPG 3751...-3750 0.31 4.2 0.6 0.10 Natural Gas 3751-5750 0.40 5.5 0.97 0.10 LPG 0-3750 0.80 0.31 4.2 0.6 0.10 LPG....4 0.7 Natural Gas >5750 0.39 5.0 1.1 LPG 3751-5750 0.32 4.4 0.7 LPG >5750 0.39 5.0 1.1 Table A97-4...

CD44 standard and CD44v10 isoform expression on leukemia cells distinctly influences niche embedding of hematopoietic stem cells.

Science.gov (United States)

Erb, Ulrike; Megaptche, Amelie Pajip; Gu, Xiaoyu; Büchler, Markus W; Zöller, Margot

2014-03-31

A blockade of CD44 is considered a therapeutic option for the elimination of leukemia initiating cells. However, anti-panCD44 can interfere with hematopoiesis. Therefore we explored, whether a CD44 variant isoform (CD44v)-specific antibody can inhibit leukemia growth without attacking hematopoiesis. As a model we used CD44v10 transfected EL4 thymoma cells (EL4-v10). The therapeutic efficacy of anti-panCD44 and anti-CD44v10 was evaluated after intravenous application of EL4/EL4-v10. Ex vivo and in vitro studies evaluated the impact of anti-panCD44 and anti-CD44v10 as well as of EL4 and EL4-v10 on hematopoietic stem cells (HSC) in cocultures with bone marrow stroma cells with a focus on adhesion, migration, cell cycle progression and apoptosis resistance. Intravenously injected EL4-v10 grow in bone marrow and spleen. Anti-panCD44 and, more pronounced anti-CD44v10 prolong the survival time. The higher efficacy of anti-CD44v10 compared to anti-panCD44 does not rely on stronger antibody-dependent cellular cytotoxicity or on promoting EL4-v10 apoptosis. Instead, EL4 compete with HSC niche embedding. This has consequences on quiescence and apoptosis-protecting signals provided by the stroma. Anti-panCD44, too, more efficiently affected embedding of HSC than of EL4 in the bone marrow stroma. EL4-v10, by catching osteopontin, migrated on bone marrow stroma and did not or weakly interfere with HSC adhesion. Anti-CD44v10, too, did not affect the HSC--bone marrow stroma crosstalk. The therapeutic effect of anti-panCD44 and anti-CD44v10 is based on stimulation of antibody-dependent cellular cytotoxicity. The superiority of anti-CD44v10 is partly due to blocking CD44v10-stimulated osteopontin expression that could drive HSC out of the niche. However, the main reason for the superiority of anti-CD44v10 relies on neither EL4-v10 nor anti-CD44v10 severely interfering with HSC--stroma cell interactions that, on the other hand, are affected by EL4 and anti-panCD44. Anti-panCD44

49 CFR 1150.44 - Caption summary.

Science.gov (United States)

2010-10-01

... 49 Transportation 8 2010-10-01 2010-10-01 false Caption summary. 1150.44 Section 1150.44... Exempt Transactions Under 49 U.S.C. 10902 for Class III Rail Carriers § 1150.44 Caption summary. The caption summary must be in the following form. The information symbolized by numbers is identified in the...

Spectrum of fungal keratitis:clinicopathologic study of 44 cases

Directory of Open Access Journals (Sweden)

Rajpal Singh Punia

2014-02-01

Full Text Available AIM:To determine the causative agents of fungal keratitis and study the predisposing factors over a period of ten years in a single tertiary care hospital.METHODS:A retrospective analysis of fungal corneal ulcers was done from 2003-2012. Patients’ clinical data were noted from the file records. Correlation of histopathological diagnosis was done with the report on fungal culture.RESULTS: Mycotic keratitis was established in 44 cases by a positive fungal culture. Direct microscopic examination of potassium hydroxide (KOH mounts revealed fungal elements in 39 cases while 40 cases showed fungus on Gram stained smears. Males (54.55% were more commonly affected than the females (45.45%. The age ranged from 18 to 82 years. Most common age group to be involved was 41-60 years. Predisposing risk factors were seen in 34 (77.27% cases. Most common findings on clinical examination were anterior chamber reaction and conjunctival injection seen in all the cases. Other common findings were stromal infiltration and hypopyon seen in 20 (45.45% and 18 (40.91% cases respectively. On histopathological examination the fungus was typed, as aspergillus in 34 cases while no definite typing was possible in 10 cases. The predominant isolate was aspergillus flavus (59.09% followed by fusarium (15.91%. Mixed fungal and bacterial infection was seen in 3 (6.82% cases.CONCLUSION:Although culture is the gold standard for definitive diagnosis of fungal keratitis, direct microscopic examination of corneal scrapings or histomorphological evaluation of biopsies allow a rapid preliminary diagnosis. Early administration of antifungal treatment helps in preventing dreadful complications.

Consumption of alcohol and cardiovascular disease mortality: a 16 year follow-up of 115,592 Norwegian men and women aged 40-44 years.

Science.gov (United States)

Tverdal, Aage; Magnus, Per; Selmer, Randi; Thelle, Dag

2017-09-01

We tested whether teetotalism explains the upturn in cardiovascular risk for non-drinkers and whether wine is a more favorable alcohol type. We studied 115,592 men and women aged 40-44 years who participated in the age 40 program in Norway in 1994-1999 and were followed for an average of 16 years with 550 cardiovascular deaths. Self-reported number of glasses of beer, wine and spirits during 14 days was transformed to alcohol units/day. One unit is approximately 8 grams of pure alcohol. The mean and median number of alcohol units/day were 0.70 and 0.46. Teetotallers had higher risk of dying from cardiovascular disease than alcohol consumers, multivariate adjusted hazard ratio (95% CI) 1.97 (1.52-2.56). The use of alcohol-related deaths as endpoint substantiated a selection of previous alcohol users to the teetotal group. Without teetotallers there was no association between alcohol consumption and cardiovascular disease mortality. However, the multivariate adjusted hazard ratio per one unit/day of wine was 0.76 (0.58-0.99). The corresponding figures for beer and spirits were 1.04 (0.94-1.15) and 0.98 (0.75-1.29). The upturn in risk for non-drinkers could be explained by a higher risk for teetotallers who likely included previous alcohol users or teetotalers who started to drink during follow-up. Wine gave the most favorable risk estimates.

12 CFR 4.4 - Washington office.

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2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Washington office. 4.4 Section 4.4 Banks and... EXAMINERS Organization and Functions § 4.4 Washington office. The Washington office of the OCC is the main office and headquarters of the OCC. The Washington office directs OCC policy, oversees OCC operations...

40 CFR 230.44 - Coral reefs.

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2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Coral reefs. 230.44 Section 230.44... Aquatic Sites § 230.44 Coral reefs. (a) Coral reefs consist of the skeletal deposit, usually of calcareous... organisms present in growing portions of the reef. (b) Possible loss of values: The discharge of dredged or...

31 CFR 31.218 - Enforcement.

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2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Enforcement. 31.218 Section 31.218 Money and Finance: Treasury Office of the Secretary of the Treasury TROUBLED ASSET RELIEF PROGRAM... more of the following sanctions: (1) Rejection of work tainted by an organizational conflict of...

Tennessee health studies agreement. Annual report for year 4, January 1 - December 31, 1995

International Nuclear Information System (INIS)

1996-04-01

The Tennessee Department of Health (TDH) has completed the fourth full year of the Oak Ridge Health Studies Agreement grant. This report summarizes the accomplishments and concerns of the State for the period January 1, 1995, to December 31, 1995. The focus of work during the fourth grant year was the actual work on the dose reconstruction. The final work plan for Task 5, Plan to Perform a Systematic Document Search was received in November 1994. Final work plans for Task 1, Investigation of Radioiodine from Radioactive Lanthanum Processing; Task 2, Investigation of Mercury Releases from Lithium Enrichment; Task 3, Investigation of Releases of PCBs from Oak Ridge Facilities; and Task 4, Investigation of Releases of Radionuclides from White Oak Creek to the Clinch River, were received in February 1995. Final work plans for Task 6, Investigation of the Quality of Historical Uranium Effluent Monitoring at Oak Ridge Facilities; and Task 7, Additional Screening of Materials Not Evaluated in the Dose Reconstruction Feasibility Study, were received in April 1995. ChemRisk's 4th Quarterly Report, for October through December 1995, is included in Attachment 1. Attachment 2 contains a study which developed a quality improvement program for data imported to the Tennessee Cancer Reporting System and Birth Defects Verification Program

Influences of Women's Employment on the Gendered Division of Household Labor over the Life Course: Evidence from a 31-Year Panel Study

Science.gov (United States)

Cunningham, Mick

2007-01-01

Drawing on data from a panel study of White women spanning 31 years, the analyses examine the influence of women's employment on the gendered division of household labor. Multiple dimensions of women's employment are investigated, including accumulated employment histories, current employment status, current employment hours, and relative income.…

Spin decomposition of the responses of 44Ca and 48Ca to 300 MeV protons

International Nuclear Information System (INIS)

Baker, F.T.; Bimbot, L.; Fergerson, R.W.; Glashausser, C.; Green, A.; Haeusser, O.; Hicks, K.; Jones, K.; Miller, C.A.; Vetterli, M.; Abegg, R.; Beatty, D.; Bonin, B.; Castel, B.; Chen, X.Y.; Cupps, V.; Djalali, C.; Henderson, R.; Jackson, K.P.; Jeppesen, R.; Nakayama, K.; Nanda, S.K.; Sawafta, R.; Yen, S.; Institut de Physique Nucleaire, F-91406 Orsay, France; Rutgers University, Piscataway, New Jersey 08854; Simon Fraser University, Burnaby, Canada V5A1S6; TRIUMF, 4004 Westbrook Mall, Vancouver, Canada V6T2A3; Los Alamos National Laboratory, Los Alamos, New Mexico 87544; Centre d'Etudes Nucleaires de Saclay, 91191 Gif sur Yvette, CEDEX, France; Queen's University, Kingston, Canada K7L3N6; University of Colorado, Boulder, Colorado 80309; University of South Carolina, Columbia, South Carolina 29208; Continuous Electron Beam Accelerator Facility, 12000 Jefferson Ave., Newport News, Virginia 23606; University of Alberta, Edmonton, Canada T6G2J1)

1991-01-01

Angular distributions of the double-differential cross section d 2 σ/dΩ dE(σ) and the spin-flip probability S nn have been measured for inclusive proton inelastic scattering from 44 Ca at 290 MeV and from 48 Ca at 318 MeV. Excitation energies up to about 50 MeV for 44 Ca and 40 MeV for 48 Ca have been investigated over the laboratory angular ranges of 3 degree to 12 degree for 44 Ca and 3 degree to 9 degree for 48 Ca. Multipole decompositions of angular distributions of both the spin-flip cross section σS nn and the estimated cross section for ΔS=0 transitions have been performed. Distributions of strengths were deduced for ΔL=1, ΔS=0 (the giant dipole), ΔL=2, ΔS=0 (the giant quadrupole), ΔL=0, ΔS=1 (the magnetic dipole), ΔL=1, ΔS=1 (the spin dipole), and ΔL=2, ΔS=1 (the spin quadrupole). The ΔS=0 summed strengths for 44 Ca are lower than for 40 Ca and 48 Ca. The spin-dipole summed strengths are found to be approximately independent of A. For 48 Ca, essentially all M1 strength observed was in the 10.23 MeV 1 + state; for 44 Ca, M1 strength was observed to be fragmented over a range of 7 to 18 Mev

Magnetoelectrochemistry of 4,4'-bis(dimethylamino)biphenyl and 4,4'-dinitrobiphenyl azacrown macrocyclic lactams

Energy Technology Data Exchange (ETDEWEB)

Domenech, Antonio [Departament de Quimica Analitica, Universitat de Valencia, Dr. Moliner 50, 46100 Burjassot, Valencia (Spain); Costero, Ana Maria; Banuls, Maria Jose; Aurell, Maria Jose [Departament de Quimica Organica, Universitat de Valencia, Dr. Moliner 50, 46100 Burjassot, Valencia (Spain)

2005-07-25

The voltammetric behaviour at carbon fibre microelectrodes under the application of static magnetic fields of two series of macrolactams containing in their structure 4,4'-bis(dimethylamino)biphenyl or 4,4'-dinitrobiphenyl groups in MeCN solution is described. The response of 4,4'-dinitrobiphenyl receptors is dominated by two successive one-electron reduction processes at -0.9 and -1.6 V versus AgCl/Ag. 4,4'-bis(dimethylamino)biphenyl-containing receptors display two one-electron oxidations above +0.8 and +1.0 V. In both cases, a dihedral/planar interconversion precedes the second electron transfer step. Upon application of moderate (0.05-0.2 T) static magnetic fields to the electrochemical cell, the rate of such dihedral/planar interconversion is lowered for both the reduction of 4,4'-dinitrobiphenyl receptors and the oxidation of 4,4'-bis(dimethylamino)biphenyl lactams. The electrochemical response of N-methylated receptors, for which different cisoid-cisoid, cisoid-transoid, and transoid-transoid forms exist, exhibits a significant peak splitting that can be associated to the presence of such conformational isomers. Application of magnetic fields produces a relative enhancement of some peaks that can be interpreted in terms of differential magnetoconvection involving such conformational isomers. (author)

Low range of ankle dorsiflexion predisposes for patellar tendinopathy in junior elite basketball players: a 1-year prospective study.

Science.gov (United States)

Backman, Ludvig J; Danielson, Patrik

2011-12-01

Patellar tendinopathy (PT) is one of the most common reasons for sport-induced pain of the knee. Low ankle dorsiflexion range might predispose for PT because of load-bearing compensation in the patellar tendon. The purpose of this 1-year prospective study was to analyze if a low ankle dorsiflexion range increases the risk of developing PT for basketball players. Cohort study (prognosis); Level of evidence, 2. Ninety junior elite basketball players were examined for different characteristics and potential risk factors for PT, including ankle dorsiflexion range in the dominant and nondominant leg. Data were collected over a 1-year period and follow-up, including reexamination, was made at the end of the year. Seventy-five players met the inclusion criteria. At the follow-up, 12 players (16.0%) had developed unilateral PT. These players were found to have had a significantly lower mean ankle dorsiflexion range at baseline than the healthy players, with a mean difference of -4.7° (P = .038) for the dominant limb and -5.1° (P = .024) for the nondominant limb. Complementary statistical analysis showed that players with dorsiflexion range less than 36.5° had a risk of 18.5% to 29.4% of developing PT within a year, as compared with 1.8% to 2.1% for players with dorsiflexion range greater than 36.5°. Limbs with a history of 2 or more ankle sprains had a slightly less mean ankle dorsiflexion range compared to those with 0 or 1 sprain (mean difference, -1.5° to -2.5°), although this was only statistically significant for nondominant legs. This study clearly shows that low ankle dorsiflexion range is a risk factor for developing PT in basketball players. In the studied material, an ankle dorsiflexion range of 36.5° was found to be the most appropriate cutoff point for prognostic screening. This might be useful information in identifying at-risk individuals in basketball teams and enabling preventive actions. A history of ankle sprains might contribute to reduced ankle

31 CFR 31.201 - Definitions.

Science.gov (United States)

2010-07-01

... agency agreement between a private sector entity and the Treasury for services under the TARP, other than... Stabilization Act of 2008. Key individual means an individual providing services to a private sector entity who... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Definitions. 31.201 Section 31.201...

Dual role of CD44 isoforms in ampullary adenocarcinoma: CD44s predicts poor prognosis in early cancer and CD44ν is an indicator for recurrence in advanced cancer

International Nuclear Information System (INIS)

Wu, Cheng-Lin; Chao, Ying-Jui; Yang, Ta-Ming; Chen, Yi-Ling; Chang, Kung-Chao; Hsu, Hui-Ping; Shan, Yan-Shen; Lai, Ming-Derg

2015-01-01

Although postoperative adjuvant chemoradiotherapies prevent recurrence for some patients with ampullary cancer, the recurrence rate is as high as 29 % in patients with stage I cancer. In an effort to identify predictors of recurrence in patients with ampullary adenocarcinoma, we investigated the clinical value of assessing standard and variant forms of CD44. Immunohistochemistry staining and reverse-transcription polymerase chain reaction (RT-PCR) was used to detect standard and variant forms of CD44 in samples of ampullary adenocarcinoma. The cDNA microarray analysis comparing tumors with or without pancreatic invasion was undertaken and analyzed by Ingenuity Pathway Analysis. The standard CD44 (CD44s) isoform was detected in 76 of 98 patients with ampullary adenocarcinoma, and the negative or weak expression of CD44s was correlated with pancreatic invasion, lymphovascular invasion, advanced stage and bone metastasis. Moderate to dense expression of CD44s was correlated with shorter overall survival in patients with localized cancer (T1 or T2 disease, P = 0.0268). The patients with advanced cancer (T3 or T4 disease) and moderate or dense CD44s expression had a trend toward better survival. Alternative splicing of CD44 was confirmed using RT-PCR, which revealed that the CD44ν3-10 isoform was only expressed in patients with cancer recurrence. Fold change of CD44ν6-10 was also increased. In addition, networks containing CD44, vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), transforming growth factor-β (TGF-β), matrix metalloproteinase 2 (MMP2), AKT, extracellular signal-regulated protein kinase 1 and 2 (ERK1/2), p38 MAPK, activated protein 1 (AP1)‚ and CTNNB1 were constructed after comparing microarray data from patients with and without pancreatic invasion. Whereas CD44s functions as tumor-promoting oncoprotein in early localized ampullary adenocarcinoma, CD44 variants are expressed in advanced cancer and patients with

Faculty of Radiation Oncology 2010 workforce survey.

Science.gov (United States)

Leung, John; Vukolova, Natalia

2011-12-01

This paper outlines the key results of the Faculty of Radiation Oncology 2010 workforce survey and compares these results with earlier data. The workforce survey was conducted in mid-2010 using a custom-designed 17-question survey. The overall response rate was 76%. The majority of radiation oncologist respondents were male (n = 212, 71%), but the majority of trainee respondents were female (n = 59, 52.7%). The age range of fellows was 32-92 years (median: 47 years; mean: 49 years) and that of trainees was 27-44 years (median: 31 years; mean: 31.7 years). Most radiation oncologists worked at more than one practice (average: two practices). The majority of radiation oncologists worked in the public sector (n = 169, 64.5%), with some working in 'combination' of public and private sectors (n = 65, 24.8%) and a minority working in the private sector only (n = 28, 10.7%). The hours worked per week ranged from 1 to 85 (mean: 44 h; median: 45 h) for radiation oncologists, while for trainees the range was 16-90 (mean: 47 h; median: 45 h). The number of new cases seen in a year ranged from 1 to 1100 (mean: 275; median: 250). Most radiation oncologists considered themselves generalists with a preferred sub-specialty (43.3%) or specialists (41.9%), while a minority considered themselves as generalists (14.8%). There are a relatively large and increasing number of radiation oncologists and trainees compared with previous years. The excessive workloads evident in previous surveys appear to have diminished. However, further work is required on assessing the impact of ongoing feminisation and sub-specialisation. © 2011 The Authors. Journal of Medical Imaging and Radiation Oncology © 2011 The Royal Australian and New Zealand College of Radiologists.

Nd:YAG 1.44 laser ablation of human cartilage

Science.gov (United States)

Cummings, Robert S.; Prodoehl, John A.; Rhodes, Anthony L.; Black, Johnathan D.; Sherk, Henry H.

1993-07-01

This study determined the effectiveness of a Neodymium:YAG 1.44 micrometers wavelength laser on human cartilage. This wavelength is strongly absorbed by water. Cadaveric meniscal fibrocartilage and articular hyaline cartilage were harvested and placed in normal saline during the study. A 600 micrometers quartz fiber was applied perpendicularly to the tissues with a force of 0.098 N. Quantitative measurements were then made of the ablation rate as a function of fluence. The laser energy was delivered at a constant repetition rate of 5 Hz., 650 microsecond(s) pulsewidth, and energy levels ranging from 0.5 joules to 2.0 joules. Following the ablation of the tissue, the specimens were fixed in formalin for histologic evaluation. The results of the study indicate that the ablation rate is 0.03 mm/mj/mm2 for hyaline cartilage and fibrocartilage. Fibrocartilage was cut at approximately the same rate as hyaline cartilage. There was a threshold fluence projected to be 987 mj/mm2 for hyaline cartilage and fibrocartilage. Our results indicate that the pulsed Nd:YAG laser operating at 1.44 micrometers has a threshold fluence above which it will ablate human cartilage, and that its ablation rate is directly proportional to fluence over the range of parameters tested. Fibrocartilage and hyaline cartilage demonstrated similar threshold fluence and ablation rates which is related to the high water content of these tissues.

JAERI TANDEM, LINAC and V.D.G. annual report 1991 April 1, 1991 - March 31, 1992

International Nuclear Information System (INIS)

1992-09-01

This annual report describes research activities which have been performed with the JAERI tandem accelerator, the electron linear accelerator and the Van de Graaff accelerator from April 1, 1991 to March 31, 1992. Summary reports of 44 papers, and list of publications, personnel and cooperative researches with universities are contained. (author)

Combined overexpression of cadherin 6, cadherin 11 and cluster of differentiation 44 is associated with lymph node metastasis and poor prognosis in oral squamous cell carcinoma.

Science.gov (United States)

Ma, Chao; Zhao, Ji-Zhi; Lin, Run-Tai; Zhou, Lian; Chen, Yong-Ning; Yu, Li-Jiang; Shi, Tian-Yin; Wang, Mu; Liu, Man-Man; Liu, Yao-Ran; Zhang, Tao

2018-06-01

Oral squamous cell carcinoma (OSCC) is a highly invasive lesion that frequently metastasizes to the cervical lymph nodes and is associated with a poor prognosis. Several adhesion factors, including cadherin 6 (CDH6), cadherin 11 (CDH11) and cluster of differentiation 44 (CD44), have been reported to be involved in the invasion and metastasis of multiple types of cancer. Therefore, the aim of the present study was to determine the expression of CDH6, CDH11 and CD44 in tumor tissues from patients with OSCC, and whether this was associated with the metastasis and survival of OSCC. The mRNA expression of the human tumor metastasis-related cytokines was examined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) in OSCC tumors with or without lymph node metastasis (n=10/group). The expression of CDH6, CDH11 and CD44 in 101 OSCC and 10 normal oral mucosa samples was examined by immunohistochemical staining. The association between overall and disease-specific survival times of patients with OSCC and the expression of these three proteins was evaluated using Kaplan-Meier curves and the log-rank test. RT-qPCR results indicated that the mRNA expression of CDH6, CDH11 and CD44 was increased in OSCC patients with lymph node metastasis (2.93-, 2.01- and 1.92-fold; P<0.05). Overexpression of CDH6, CDH11 and CD44 was observed in 31/35 (89%), 25/35 (71%) and 31/35 (89%) patients, respectively. The number of OSCC patients with lymph node metastasis exhibiting CDH6, CDH11 and CD44 overexpression was significantly higher than the number of patients without lymph node metastasis exhibiting overexpression of these proteins (P=0.017, P=0.038 and P=0.007, respectively). OSCC patients with high co-expression of CDH6, CDH11 and CD44 exhibited lower disease-specific survival times (P=0.047; χ 2 =3.933) when compared with OSCC patients with low co-expression of these adhesion factors. CDH6, CDH11 and CD44 serve important roles in OSCC metastasis and the combined use

CD44 standard and CD44v10 isoform expression on leukemia cells distinctly influences niche embedding of hematopoietic stem cells

OpenAIRE

Erb, Ulrike; Megaptche, Amelie Pajip; Gu, Xiaoyu; Büchler, Markus W; Zöller, Margot

2014-01-01

Background A blockade of CD44 is considered a therapeutic option for the elimination of leukemia initiating cells. However, anti-panCD44 can interfere with hematopoiesis. Therefore we explored, whether a CD44 variant isoform (CD44v)-specific antibody can inhibit leukemia growth without attacking hematopoiesis. As a model we used CD44v10 transfected EL4 thymoma cells (EL4-v10). Methods The therapeutic efficacy of anti-panCD44 and anti-CD44v10 was evaluated after intravenous application of EL4/...

20 CFR 901.44 - Hearings.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Hearings. 901.44 Section 901.44 Employees' Benefits JOINT BOARD FOR THE ENROLLMENT OF ACTUARIES REGULATIONS GOVERNING THE PERFORMANCE OF ACTUARIAL... complaint for the suspension or termination of an enrolled actuary. Hearings shall be stenographically...

An analysis of the feelings of pregnant women at risk of preterm labour.

Science.gov (United States)

Sulima, Magdalena; Makara-Studzińska, Marta; Lewicka, Magdalena; Wiktor, Krzysztof; Kanadys, Katarzyna; Wiktor, Henryk

2014-01-01

The aim of the study was an analysis of the feelings of pregnant women at risk ofpreterm labour. 313 expectant mothers aged between 18 to 44 years (ranges: 18-25, 26-30 and 31-44 years) with no psychological disorders, hospitalized and treated due to the risk of preterm labour were surveyed. All the examined pregnant women expressed voluntary and informed consent for the participation in the survey. Each of the questionnaires given to the examined pregnant women contained: a questionnaire form devised by the authors, to establish the characteristics of the surveyed expectant mothers, and the following research standardized tool - Negative and Positive Feelings Scale by P. Brzozowski. The value of the mean level of positive feel- ings state in the group of patients aged 31-44 years with higher education was significantly higher (p feelings as a condition of pregnant women in the study group (p > 0.05). There were no significant statistical differences (p > 0.05) between the level of negative feel- ings trait and age. It was found, however, that the level of negative feelings trait was significantly lower (p = 0.0009) in pregnant women with higher education than in pregnant women who had completed secondary education. 1. Among pregnant women at risk of pre- term labour, higher levels of positive feelings were found in pregnant women aged 31-44 years with higher education, being married and residents of a provincial city. 2. In order to reduce negative feelings in pregnant women at risk of preterm labour it seems important to implement appropriate psychological and prophylactic management, provide adequate care in the pregnancy pathology department, as well as support from the medical staff and the family. These activities should be targeted particularly at younger women with primary education or vocational training, not being married and living in rural areas.

Smoking in the population from 15 to 44 years of age from the city of Tunja, Colombia Tabaquismo en la población de 15 a 44 años de la ciudad de Tunja, Colombia Tabagismo na população de 15 a 44 anos da cidade deTunja, Colômbia

Directory of Open Access Journals (Sweden)

Judith Susana Pedraza López

2012-07-01

Full Text Available Objective. To describe tobacco use, the situation of control measures established in the MPOWER plan, and knowledge regarding smoking and Legislation 1335 of 2009 in individuals from 15 to 44 years of age from the city of Tunja in the department of Boyacá (Colombia. Methodology. Cross-sectional descriptive study carried out in 2010, with the participation of 461 individuals from 15 to 44 years of age from the urban area. A two-stage quota sampling was made. Information was gathered by using the Global Adult Tobacco Survey. Results. A total of 27% of the participants were smokers; the average age for the start of tobacco use was 16 years; 80% of those surveyed manifested annoyance with respect to tobacco smoke in the environment; 33% were exposed to second-hand smoke at the work place and 20% in their homes. Tobacco use was found in public places, as well as actions for promotion and publicity of tobacco products in grocery stores and communication media. Seventy nine percent of the smokers have tried to give up smoking and 24% of them have received information to this respect by a healthcare professional. Conclusion. Tobacco use in Tunja is a public health problem that requires reinforcing strategies to prevent this problem in the city.Objetivo. Describir el consumo de tabaco, la situación de las medidas de control establecidas en el plan MPOWER y los conocimientos frente al tabaquismo y la Ley 1335 de 2009 en personas entre los 15 y 44 años de la ciudad de Tunja (Colombia. Metodología. Estudio descriptivo transversal realizado en 2010. Participaron 461 personas entre los 15 y 44 años del área urbana. Se hizo muestreo bietápico por cuotas. La información se recolectó haciendo uso de la Encuesta Global de Tabaquismo en adultos. Resultados. El 27% de los participantes era fumador; el promedio de edad de inicio de consumo de tabaco fue 16 años. El 80% de los encuestados manifestó molestia por el humo de tabaco en el ambiente. Expuestos

NNC Limited (formerly National Nuclear Corporation Limited) report and financial statements 31 March 1989

International Nuclear Information System (INIS)

1989-01-01

Developments in the year ending 31st March 1989 within NNC Ltd. are reviewed in outline. These include work on the Advanced Gas Cooled Reactor Power Stations under construction at Heysham 2 and Torness; operational support and maintenance work on most of the UK's nuclear power stations; Pressurized Water Reactor work on systems and safety, engineering support and research and development; management support of the Ministry of Defence at the AWE site at Aldermaston and a range of services relating to nuclear submarines. Financial statements for the year conclude, and form the bulk of the report. (UK)

Areva at March 31, 2016

International Nuclear Information System (INIS)

Lachaux, Manuel; Jugean, Anne-Sophie

2016-01-01

In the first quarter of 2016, AREVA generated consolidated revenue of 826 million euros, a decrease of 0.8% (-2.2% like for like) compared with the same period in 2015, due in particular to the schedule of uranium deliveries. Foreign exchange had a positive impact of 12 million euros over the period. At March 31, 2016, the group's backlog reached 33.6 billion euros, up sharply compared to December 31, 2015 (29 billion euros), and represented eight years of revenue. It reflects in particular multi-year commercial agreements signed with EDF in early 2016. The order intake for the first quarter of 2016 totaled 6.1 billion euros, a strong increase in relation to the first quarter of 2015 (0.3 billion euros)

7 CFR 906.44 - Safeguards.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Safeguards. 906.44 Section 906.44 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... pursuant to § 906.41 or § 906.42 from entering channels of trade for other than the specific purpose...

30 CFR 44.24 - Discovery.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Discovery. 44.24 Section 44.24 Mineral... Discovery. Parties shall be governed in their conduct of discovery by appropriate provisions of the Federal... discovery. Alternative periods of time for discovery may be prescribed by the presiding administrative law...

Quantification of protein thiols and dithiols in the picomolar range using sodium borohydride and 4,4'-dithiodipyridine

DEFF Research Database (Denmark)

Hansen, Rosa E; Østergaard, Henrik; Nørgaard, Per

2007-01-01

Experimental determination of the number of thiols in a protein requires methodology that combines high sensitivity and reproducibility with low intrinsic thiol oxidation disposition. In detection of disulfide bonds, it is also necessary to efficiently reduce disulfides and to quantify...... the liberated thiols. Ellman's reagent (5,5'-dithiobis-[2-nitrobenzoic acid], DTNB) is the most widely used reagent for quantification of protein thiols, whereas dithiothreitol (DTT) is commonly used for disulfide reduction. DTNB suffers from a relatively low sensitivity, whereas DTT reduction is inconvenient...... sodium borohydride and the thiol reagent 4,4'-dithiodipyridine (4-DPS). Because borohydride is efficiently destroyed by the addition of acid, the complete reduction and quantification can be performed conveniently in one tube without desalting steps. Furthermore, the use of reverse-phase high...

Elephant (Loxodonta africana home ranges in Sabi Sand Reserve and Kruger National Park: a five-year satellite tracking study.

Directory of Open Access Journals (Sweden)

Bindi Thomas

Full Text Available During a five-year GPS satellite tracking study in Sabi Sand Reserve (SSR and Kruger National Park (KNP we monitored the daily movements of an elephant cow (Loxodonta africana from September 2003 to August 2008. The study animal was confirmed to be part of a group of seven elephants therefore her position is representative of the matriarchal group. We found that the study animal did not use habitat randomly and confirmed strong seasonal fidelity to its summer and winter five-year home ranges. The cow's summer home range was in KNP in an area more than four times that of her SSR winter home range. She exhibited clear park habitation with up to three visits per year travelling via a well-defined northern or southern corridor. There was a positive correlation between the daily distance the elephant walked and minimum daily temperature and the elephant was significantly closer to rivers and artificial waterholes than would be expected if it were moving randomly in KNP and SSR. Transect lines established through the home ranges were surveyed to further understand the fine scale of the landscape and vegetation representative of the home ranges.

Elephant (Loxodonta africana) home ranges in Sabi Sand Reserve and Kruger National Park: a five-year satellite tracking study.

Science.gov (United States)

Thomas, Bindi; Holland, John D; Minot, Edward O

2008-01-01

During a five-year GPS satellite tracking study in Sabi Sand Reserve (SSR) and Kruger National Park (KNP) we monitored the daily movements of an elephant cow (Loxodonta africana) from September 2003 to August 2008. The study animal was confirmed to be part of a group of seven elephants therefore her position is representative of the matriarchal group. We found that the study animal did not use habitat randomly and confirmed strong seasonal fidelity to its summer and winter five-year home ranges. The cow's summer home range was in KNP in an area more than four times that of her SSR winter home range. She exhibited clear park habitation with up to three visits per year travelling via a well-defined northern or southern corridor. There was a positive correlation between the daily distance the elephant walked and minimum daily temperature and the elephant was significantly closer to rivers and artificial waterholes than would be expected if it were moving randomly in KNP and SSR. Transect lines established through the home ranges were surveyed to further understand the fine scale of the landscape and vegetation representative of the home ranges.

Global glacier and ice sheet surface velocities derived from 31 years of Landsat imagery

Science.gov (United States)

Gardner, A. S.; Scambos, T. A.; Fahnestock, M. A.

2016-12-01

Glaciers and ice sheets are contributing substantial volumes of water to the world's oceans due to enhanced melt resulting from changes in ocean and atmospheric conditions and respective feedbacks. Improving understanding of the processes leading to accelerated rates of ice loss is necessary for reducing uncertainties sea level projections. One key to doing this is to assemble and analyze long records of glacier change that characterize grounded ice response to changes in driving stress, buttressing, and basal conditions. As part of the NASA funded GO_LIVE project we exploit 31 years of Landsat imagery to construct detailed time histories of global glacier velocities. Early exploration of the dataset reveals the diversity of information to be gleaned: sudden tidewater glacier speedups in the Antarctic Peninsula, rifting of Antarctic ice shelves, high variability in velocities near glacier grounding lines, frequent surge activity in the mountainous regions of Alaska and High Mountain Asia, and the slowdown of land-terminating valley glaciers in Arctic Canada and elsewhere.

Nesting by Golden Eagles on the North Slope of the Brooks Range in Northeastern Alaska

Science.gov (United States)

Young, Donald D.; McIntyre, Carol L.; Bente, Peter J.; McCabe, Thomas R.; Ambrose, Robert E.

1995-01-01

Twenty-two Golden Eagle (Aquila chrysaetos) nesting territories and 31 occupied eagle nests were documented on the north slope of the Brooks Range in northeastern Alaska, 1988-1990, in an area previously thought to be marginal breeding habitat for eagles. The mean number of young/successful nest was 1.25 in 1988, 1.27 in 1989, and 1.13 in 1990; means did not differ significantly among years. Eighty percent (20/25) of the nestlings for which age was estimated were assumed to have successfully fledged. Nesting success was 79% (11/14) in 1989, the only year nesting success could be determined. Laying dates ranged from 23 March (1990) to 11 May (1989) with mean estimated laying dates differing significantly among years. Annual variation in nesting phenology coincided with annual differences in snow accumulations during spring. These results indicate that Golden Eagles consistently and successfully breed at the northern extent of their range in Alaska, although, productivity may be lower than that for eagles at more southern latitudes.

Nonbreeding home‐range size and survival of lesser prairie‐chickens

Science.gov (United States)

Robinson, Samantha G.; Haukos, David A.; Plumb, Reid T.; Lautenbach, Joseph M.; Sullins, Daniel S.; Kraft, John D.; Lautenbach, Jonathan D.; Hagen, Christian A.; Pitman, James C.

2018-01-01

The lesser prairie‐chicken (Tympanuchus pallidicinctus), a species of conservation concern with uncertain regulatory status, has experienced population declines over the past century. Most research on lesser prairie‐chickens has focused on the breeding season, with little research conducted during the nonbreeding season, a period that exerts a strong influence on demography in other upland game birds. We trapped lesser prairie‐chickens on leks and marked them with either global positioning system (GPS) satellite or very high frequency (VHF) transmitters to estimate survival and home‐range size during the nonbreeding season. We monitored 119 marked lesser prairie‐chickens in 3 study areas in Kansas, USA, from 16 September to 14 March in 2013, 2014, and 2015. We estimated home‐range size using Brownian Bridge movement models (GPS transmitters) and fixed kernel density estimators (VHF transmitters), and female survival using Kaplan–Meier known‐fate models. Average home‐range size did not differ between sexes. Estimated home‐range size was 3 times greater for individuals fitted with GPS satellite transmitters ( = 997 ha) than those with VHF transmitters ( = 286 ha), likely a result of the temporal resolution of the different transmitters. Home‐range size of GPS‐marked birds increased 2.8 times relative to the breeding season and varied by study area and year. Home‐range size was smaller in the 2013–2014 nonbreeding season ( = 495 ha) than the following 2 nonbreeding seasons ( = 1,290 ha and  = 1,158 ha), corresponding with drought conditions of 2013, which were alleviated in following years. Female survival () was high relative to breeding season estimates, and did not differ by study area or year ( = 0.73 ± 0.04 [SE]). Future management could remain focused on the breeding season because nonbreeding survival was 39–44% greater than the previous breeding season; however, considerations of total space

Determinants of Local Progression After Computed Tomography-Guided Percutaneous Radiofrequency Ablation for Unresectable Lung Tumors: 9-Year Experience in a Single Institution

International Nuclear Information System (INIS)

Okuma, Tomohisa; Matsuoka, Toshiyuki; Yamamoto, Akira; Oyama, Yoshimasa; Hamamoto, Shinichi; Toyoshima, Masami; Nakamura, Kenji; Miki, Yukio

2010-01-01

The purpose of this study was to retrospectively determine the local control rate and contributing factors to local progression after computed tomography (CT)-guided radiofrequency ablation (RFA) for unresectable lung tumor. This study included 138 lung tumors in 72 patients (56 men and 16 women; age 70.0 ± 11.6 years (range 31-94); mean tumor size 2.1 ± 1.2 cm [range 0.2-9]) who underwent lung RFA between June 2000 and May 2009. Mean follow-up periods for patients and tumors were 14 and 12 months, respectively. The local progression-free rate and survival rate were calculated to determine the contributing factors to local progression. During follow-up, 44 of 138 (32%) lung tumors showed local progression. The 1-, 2-, 3-, and 5-year overall local control rates were 61, 57, 57, and 38%, respectively. The risk factors for local progression were age (≥70 years), tumor size (≥2 cm), sex (male), and no achievement of roll-off during RFA (P < 0.05). Multivariate analysis identified tumor size ≥2 cm as the only independent factor for local progression (P = 0.003). For tumors <2 cm, 17 of 68 (25%) showed local progression, and the 1-, 2-, and 3-year overall local control rates were 77, 73, and 73%, respectively. Multivariate analysis identified that age ≥70 years was an independent determinant of local progression for tumors <2 cm in diameter (P = 0.011). The present study showed that 32% of lung tumors developed local progression after CT-guided RFA. The significant risk factor for local progression after RFA for lung tumors was tumor size ≥2 cm.

Early radiation effects in highly apoptotic murine lymphoma xenografts monitored by 31P magnetic resonance spectroscopy

International Nuclear Information System (INIS)

Sakurai, Hideyuki; Mitsuhashi, Norio; Murata, Osamu; Kitamoto, Yoshizumi; Saito, Yoshihiro; Hasegawa, Masatoshi; Akimoto, Tetsuo; Takahashi, Takeo; Nasu, Sachiko; Niibe, Hideo

1998-01-01

Purpose: Phosphorus-31 magnetic resonance spectra ( 31 P-MRS) were obtained from highly apoptotic murine lymphoma xenografts before and up to 24 hr following graded doses of radiation ranging from 2 to 30 Gy. Radiation-induced apoptosis was also estimated up to 24 hr by scoring apoptotic cells in tumor tissue. Methods and Materials: Highly apoptotic murine lymphoma cells, EL4, were subcutaneously transplanted into C57/BL mice. At 7 days after transplantation, radiation was given to the tumor with a single dose at 3, 10, and 30 Gy. The β-ATP/Pi, PME/Pi, and β-ATP/PME values were calculated from the peak area of each spectrum. Radiation-induced apoptosis was scored with counting apoptotic cells on hematoxylin and eosin stained specimens (%apoptosis). Results: The values of % apoptosis 4, 8, and 24 hr after radiation were 21.8, 19.6, and 4.6% at 3 Gy, 35.1, 25.6, and 14.8% at 10 Gy, 38.4, 38.0, and 30.6% at 30 Gy, respectively (cf. 4.4% in control). There was no correlation between early change in β-ATP/Pi and % apoptosis at 4 hr after radiation when most of the apoptosis occurred. An early decrease in PME/Pi was observed at 4 hr after radiation dose at 30 Gy. For each dose, the values of β-ATP/Pi 24 hr after radiation were inversely related to radiation dose. Conclusion: The increase in β-ATP/Pi observed by 31 P-MRS was linked to the degree of histological recovery from radiation-induced apoptosis

27 CFR 44.144 - Opening.

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2010-04-01

... PAYMENT OF TAX, OR WITH DRAWBACK OF TAX Operations by Export Warehouse Proprietors Inventories § 44.144 Opening. An opening inventory shall be made by the export warehouse proprietor at the time of commencing... permit issued under § 44.93. A similar inventory shall be made by the export warehouse proprietor when he...

28 CFR 66.44 - Termination for convenience.

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2010-07-01

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Ultra-High Resolution Optical Coherence Tomography Imaging of Unilateral Drusen in a 31 Year Old Woman.

Science.gov (United States)

de Carlo, Talisa E; Adhi, Mehreen; Lu, Chen D; Duker, Jay S; Fujimoto, James G; Waheed, Nadia K

We report a case of widespread unilateral drusen in a healthy 31 year old Caucasian woman using multi-modal imaging including ultra-high resolution optical coherence tomography (UHR-OCT). Dilated fundus exam showed multiple drusen-like lesions in the posterior pole without heme or fluid. Fundus auto fluorescence demonstrated hyperautofluorescent at the deposits. Fluorescein angiography revealed mild hyperfluorescence and staining of the lesions. Spectral-domain optical coherence tomography (SD-OCT) OS showed accumulations in the temporal macula at Bruch's membrane. UHR-OCT provided improved axial resolution compared to the standard 5 μm on the commercial SD-OCT and confirmed the presence of deposits in Bruch's membrane, consistent with drusen. The retinal layers were draped over the excrescences but did not show any disruption.

31 CFR 357.31 - Certifying individuals.

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2010-07-01

... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Certifying individuals. 357.31 Section 357.31 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL... institutions, corporate central credit unions, and institutions that are members of Treasury-recognized...

44 CFR 71.2 - Definitions.

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2010-10-01

... as by a private sector insurance company under the Write Your Own Program as authorized by 44 CFR... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Definitions. 71.2 Section 71... LEGISLATION § 71.2 Definitions. (a) Except as otherwise provided in this part, the definitions set forth in...

Sigma models in (4,4) harmonic superspace

International Nuclear Information System (INIS)

Ivanov, E.; Joint Inst. for Nuclear Research, Dubna; Sutulin, A.

1994-04-01

We define basics of (4,4) 2D harmonic superspace with two independent sets of SU(2) harmonic variables and apply it to construct new superfield actions of (4,4) supersymmetric two-dimensional sigma models with torsion and mutually commuting left and right complex structures, as well as of their massive deformations. We show that the generic off-shell sigma model action is the general action of constrained analytic superfields q (1,1) representing twisted N=4 multiplets in (4,4) harmonic superspace. The massive term of q (1,1) is shown to be unique; it generates a scalar potential the form of which is determined by the metric on the target bosonic manifold. We discuss in detail (4,4) supersymmetric group manifold SU(2)xU(1) WZNW sigma model and its Liouville deformation. A deep analogy of the relevant superconformally invariant analytic superfield action to that of the improved tensor N=2 4D multiplet is found. We define (4,4) duality transformation and find new off-shell dual representations of the previously constructed actions via unconstrained analytic (4,4) superfields. The main peculiarities of the (4,4) duality transformation are: (i) It preserves manifest (4,4) supersymmetry; (ii) dual actions reveal a gauge invariance needed for the onshell equivalence to the original description; (iii) in the actions dual to the massive ones 2D supersymmetry is modified off shell by SU(2) tensor central charges. The dual representation suggests some hints of how to describe (4,4) models with non-commuting complex structures in the harmonic superspace. (orig.)

45 CFR 92.44 - Termination for convenience.

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2010-10-01

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14 CFR 1273.44 - Termination for convenience.

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2010-01-01

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2010-01-01

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The Manitoba Hydro-Electric Board, 40th annual report for the year ended March 31, 1991

International Nuclear Information System (INIS)

1991-01-01

A report is presented of the year's activities of the corporation responsible for supplying electric power to Manitoba. The corporation serves all areas of the province except central Winnipeg, and its 11 generating stations have a capability of nearly 4 million kW, of which ca 3.5 millon kW is hydraulic. The various sections of the report present information on customer services; electricity generated, purchased, and exported; system development, including construction of new power plants; research and development; environmental services; personnel policies; and water management. Financial statements are also provided. Highlights of the year include: a net income of $48.6 million for the year ending 31 March 1991; the first four units of the Limestone Generating Station were placed in service ahead of schedule and under budget; the Corporation's development plans for major generation and transmission facilities received the endorsement of the Public Utilities Board; a major settlement was reached with the people of Chemawawin/Easterville and Moose Lake with respect to outstanding responsibilities related to the development of the Grand Rapids Generating Station; an agreement was reached with the Cross Lake Band of Indians to construct a weir that will create a water regime on Cross Lake that reduces or eliminates the adverse effects caused by the Lake Winnipeg Regulation Project; an export sale agreement was signed with Ontario Hydro which provides for the delivery by Manitoba Hydro of 200 megawatts of firm capacity in each year of the three-year agreement; a major commitment to energy conservation; and the employee safety record was substantially improved. 11 figs

Acute Corneal Hydrops in Children with Primary Infantile Glaucoma: A Report of 31 Cases over 23 Years at the LVPEI.

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Anil K Mandal

Full Text Available Relatively little data exist regarding the outcomes of children with primary infantile glaucoma presenting with acute corneal hydrops. The aim of our study was to determine the surgical outcome of children of infantile glaucoma who presented with acute corneal hydrops.In total, 38 eyes of 31 consecutive children of infantile glaucoma presented with acute corneal hydrops who underwent primary combined trabeculotomy-trabeculectomy (CTT by a single surgeon from January 1990 to December 2012 at the LV Prasad Eye Institute (LVPEI, a tertiary eye care centre in Southern India were enrolled in this retrospective study. Primary outcome measures were intraocular pressure (IOP control (IOP ≤ 16 mmHg under anaesthesia or IOP ≤ 21 mmHg without anaesthesia and clearance of corneal edema. Secondary outcome measures were visual acuity (VA, corneal diameter, bleb appearance, intraoperative and postoperative complications.Mean age at presentation was 6.4 months (range, 2-11 months and seven eyes (23% had bilateral affliction. At presentation, all eyes (100% had moderate to severe degree of corneal edema with a mean preoperative IOP of 25.6 ±5.1 mmHg. Postoperatively, the IOP reduced to 12.0 ± 3.8 mmHg (difference = -13.6, 95% CI = -15.7 to -11.5, t = -13.18, p<0.0001, and the percentage reduction in IOP was 53.05%. Preoperatively 83% of the eyes were on antiglaucoma medication, and postoperatively 2 eyes (5.3% required 1 antiglaucoma medication for control of IOP. Preoperatively, corneal edema was present in all eyes and postoperatively it cleared in all of them. Significant myopic astigmatism was present in 28 eyes (74%, the commonest being compound myopic astigmatism (75% followed by simple myopic astigmatism (21%. Normal VA (best-corrected VA; BCVA ≥ 20/60 was achieved in 44.4% of the eyes and 22.2% eyes had low vision (BCVA, <20/60 to 20/400. Complete success (IOP control and clearance of corneal oedema was obtained in 94.7% eyes. There were no

20 CFR 437.44 - Termination for convenience.

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2010-04-01

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29 CFR 1470.44 - Termination for convenience.

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2010-07-01

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Monitoring of the insecticide trichlorfon by phosphorus-31 nuclear magnetic resonance (31P NMR) spectroscopy

International Nuclear Information System (INIS)

Talebpour, Zahra; Ghassempour, Alireza; Zendehzaban, Mehdi; Bijanzadeh, Hamid Reza; Mirjalili, Mohammad Hossein

2006-01-01

Trichlorfon is an organophosphorus insecticide, which is extensively being used for protection of fruit crops. Trichlorfon is a thermal labile compound, which cannot be easily determined by gas chromatography (GC) and has no suitable group for sensitive detection by high performance liquid chromatography (HPLC). In this study, a 31 P nuclear magnetic resonance ( 31 P NMR) has been described for monitoring of trichlorfon without any separation step. The quantitative works of 31 P NMR spectroscopy has been performed in the presence of an internal standard (hexamethylphosphoramide). Limit of detection (LOD) for this method has been found to be 55 mg L -1 , without any sample preparation, and the linear working range was 150-5500 mg L -1 . Relative standard deviation (R.S.D.%) of the method for three replicates within and between days was obtained ≤9%. The average recovery efficiency was approximately 99-112%. This method was applied for monitoring trichlorfon in a commercial insecticide sample and tomato sample

HI structures in M31

International Nuclear Information System (INIS)

Brinks, E.; Bajaja, E.

1983-01-01

The author reports on the preparation of a list of some 250 holes found in an HI survey of M31. The maps which have been used in search for holes in the HI distribution were done at a resolution of Δα x Δd x ΔV = 24'' x 36'' x 8.2 km s -1 . All these 147 channel maps cover the whole velocity range of HI over most of the optical image of M31. The list is made eliminating any personal bias or accidental mistakes. The list could be divided into three classes: spatially-unresolved holes (in velocity); resolved small holes; and large holes. Two holes are discussed in more detail. (Auth.)

The levels of anti-HPV16/18 and anti-HPV31/33/35/45/52/58 antibodies among AS04-adjuvanted HPV16/18 vaccinated and non-vaccinated Ugandan girls aged 10-16 years.

Science.gov (United States)

Nakalembe, Miriam; Banura, Cecily; Namujju, Proscovia B; Mirembe, Florence M

2014-01-01

Data on Human Papilloma virus (HPV) vaccine immune response in sub-Saharan Africa is still sparse yet such knowledge is critical for optimal implementation and monitoring of HPV vaccines. Our primary objective was to evaluate levels of anti-HPV-16/18 antibodies and six other 'high risk' HPV (hrHPV) types among the vaccinated and unvaccinated Ugandan girls. We conducted a cross sectional study among AS04-adjuvanted HPV-16/18 vaccinated and unvaccinated school girls aged 10-16 years in Western Uganda using purposive sampling. The vaccinated girls were at 18 months post vaccination. After consenting and assenting, data was collected using interviewer administered questionnaires for demographics and sexual history. Blood was drawn from which serum samples were analysed by the multiplex HPV serology technology to determine anti-HPV antibody levels to HPV-16/18 and six other hrHPV types (31, 33, 35, 45, 52 and 58). The antibody levels were expressed as Median Fluorescent Intensity (MFI). A total of 207 vaccinated [mean age 13.1 years (SD 1.5); range 10-16 years] and 197 unvaccinated girls [mean age 13.6 years (SD 1.3); range 10-16 years] participated in the study. Sexual activity was self reported among 14/207 (6.8%) vaccinated and 5/197 (2.5%) unvaccinated girls. The MFI levels for HPV-16 and HPV-18 were 15 and 20 times higher respectively in the vaccinated girls than in the unvaccinated girls. HPV-16 mean MFI level was 4691(SD 1812; 95% CI: 4438-4958) among the vaccinated compared to 218 (SD 685; 95% CI: 190-252) among the unvaccinated girls. For HPV-18 the mean MFI level was 1615 (SD 1326; 95% CI: 1470-1776) among the vaccinated compared to MFI 103 (SD 506; 95% CI: 88 -121) among unvaccinated girls. In addition antibody levels to non vaccine hrHPV types (31, 33, 35, 45, 52 and 58) were all significantly higher in the vaccinated group than in the unvaccinated group (plevel of antibodies to HPV-16/18 and other non-vaccine hrHPV types compared to the unvaccinated girls

Breast cancer characteristics in very young Egyptian women ≤35 years

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Farouk O

2016-04-01

Full Text Available Omar Farouk,1 Mohamed A Ebrahim,2 Ahmad Senbel,1 Ziad Emarah,2 Waleed Abozeed,3 Mohamed O Seisa,4 Summer Mackisack,4 Salah Abdel Jalil,4 Safaa Abdelhady4 1Surgical Oncology Unit, 2Medical Oncology Unit, Oncology Center, Faculty of Medicine, 3Clinical Oncology and Nuclear Medicine Department, 4Faculty of Medicine, Mansoura University, Mansoura, Egypt Background: Breast cancer in very young patients represents a unique issue that needs more attention as the number of cases is increasing and it has special characteristics at presentation, diagnosis, and biologic behaviors which reflect on both treatment strategies and survival. The aim of the current study was to analyze and report the clinico-pathological characteristics and treatment procedures used for breast cancer in very young patients over the last decade in a single Egyptian cancer center. Patients and methods: A retrospective study was conducted in the Oncology Center – Mansoura University, where the data of all breast cancer patients, between September 2006 and August 2015, were reviewed. Among 4,628 patients who were diagnosed with breast cancer during this period, only 300 patients aged ≤35 years had complete registry data. Clinico-pathological characteristics, therapeutic procedures, and survival outcome were reported. Results: Three hundred and seventy-nine patients (8.19% were aged ≤35 years at the time of presentation. The age ranged between 21 and 35 years, and the mean age was 31 years (±3 standard deviation. Positive family history of breast cancer was found in 12.3%, and metastatic presentation was seen in 4.7%. The rate of axillary lymph nodes involvement was 75.7%. The estrogen receptor-negative disease was found in 51%, and among 217 patients who did HER2 test, 82 patients (37.8% were HER2 positive, while triple-negative subtype was found in 57 patients (26.4%. Ki 67 percentage ranged between 3% and 66% (median was 35%. The median disease-free survival was 61 months

22 CFR 135.44 - Termination for convenience.

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2010-04-01

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15 CFR 24.44 - Termination for convenience.

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2010-01-01

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30 CFR 44.11 - Contents of petition.

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2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Contents of petition. 44.11 Section 44.11... ADMINISTRATIVE REQUIREMENTS RULES OF PRACTICE FOR PETITIONS FOR MODIFICATION OF MANDATORY SAFETY STANDARDS Initial Procedure for Petitions for Modification § 44.11 Contents of petition. (a) A petition for...

7 CFR 868.44 - New original inspection.

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2010-01-01

... 7 Agriculture 7 2010-01-01 2010-01-01 false New original inspection. 868.44 Section 868.44... FOR CERTAIN AGRICULTURAL COMMODITIES Regulations Original Inspection Service § 868.44 New original... applicant may request a new original inspection on any previously inspected lot; except that a new original...

Etiologic Causes and Epidemiological Characteristics of Patients with Intraocular Foreign Bodies: Retrospective Analysis of 1340 Cases over Ten Years

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Lin Li

2018-01-01

Full Text Available Objective. Patients with intraocular foreign bodies were retrospectively analyzed. Population characteristics, pathogenic factors, and the outcomes during the past ten years were discussed. Design. Retrospective case series study. Method. Medical records of 1340 patients hospitalized in Beijing Tongren Hospital from January 1, 2004, to December 31, 2013, were collected. Results. Average age was 33.0 ± 13.8 (1–76 years old in 1340 patients. There were more males (1270, 94.8% than females (70, 5.2%. Patients from outside of Beijing (82.1%, n=1100 prevailed. Farmers (32.1%, n=430 and workers (22.3%, n=299 were the top two affected professions. Leading two causes were splashing of foreign bodies (SFB (58.6%, n=785 and explosives (31.8%, n=426. More males than females were injured by SFB (59.4% versus 44.3%, P=0.009. Firework injury was the commonest (41.6% versus 3.1%–15.3%, P<0.05 in patients under nine. The annual percentages in patients over 50 increased (P<0.001 and in patients by explosives decreased (P=0.027. Conclusion. Most patients in this study were young males from outside of Beijing and farmers. SFB accounted most for patients over 10 years old and fireworks for those under ten. Patients over 50 increased while those by explosives decreased annually over the period.

Spectroscopic quantification of soil phosphorus forms by 31P-NMR after nine years of organic or mineral fertilization

International Nuclear Information System (INIS)

Gatiboni, Luciano Colpo; Brunetto, Gustavo; Rheinheimer, Danilo dos Santos; Kaminski, Joao; Flores, Alex Fabiani Claro; Lima, Maria Angelica Silveira; Girotto, Eduardo; Copetti, Andre Carlos Cruz; Pandolfo, Carla Maria; Veiga, Milton

2013-01-01

Long-standing applications of mineral fertilizers or types of organic wastes such as manure can cause phosphorus (P) accumulation and changes in the accumulated P forms in the soil. The objective of this research was to evaluate the forms of P accumulated in soils treated with mineral fertilizer or different types of manure in a long-term experiment. Soil was sampled from the 0-5 cm layer of plots fertilized with five different nutrient sources for nine years: 1) control without fertilizer; 2) mineral fertilizer at recommended rates for local conditions; 3) 5 t ha -1 year -1 of moist poultry litter; 4) 60 m 3 ha -1 year -1 of liquid cattle manure and 5) 40 m 3 ha -1 year -1 of liquid swine manure. The 31 P-NMR spectra of soil extracts detected the following P compounds: orthophosphate, pyrophosphate, inositol phosphate, glycerophosphate, and DNA. The use of organic or mineral fertilizer over nine years did not change the soil P forms but influenced their concentration. Fertilization with mineral or organic fertilizers stimulated P accumulation in inorganic forms. Highest inositol phosphate levels were observed after fertilization with any kind of manure and highest organic P concentration in glycerophosphate form in after mineral or no fertilization. (author)

Study of the supernova nucleosynthesis 40Ca(α,γ)44Ti reaction: progress report

International Nuclear Information System (INIS)

Nassar, H.; Paul, M.; Ghelberg, S.; Ofan, A.; Trubnikov, N.; Ben-Dov, Y.; Hass, M.; Nara Singh, B.S.

2005-01-01

We report on a study of the α-capture reaction on 40 Ca in the energy range relevant to supernova nucleosynthesis (T 9 ∼ 0.8-3). The experiment measures the overall yield of 44 Ti nuclei produced in an activation of a thick 4 He target by a 40 Ca beam. Preliminary results show a significantly stronger yield than observed in previous measurements in the range T 9 ∼ 1.5-3

49 CFR 18.44 - Termination for convenience.

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2010-10-01

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34 CFR 80.44 - Termination for convenience.

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2010-07-01

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45 CFR 1174.44 - Termination for convenience.

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45 CFR 602.44 - Termination for convenience.

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2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Termination for convenience. 602.44 Section 602.44 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION UNIFORM... Requirements § 602.44 Termination for convenience. Except as provided in § 602.43 awards may be terminated in...

Annual variation in δ13C values of maize and wheat: Effect on estimates of decadal scale soil carbon turnover

DEFF Research Database (Denmark)

Christensen, Bent Tolstrup; Olesen, Jørgen E; Hansen, Elly Møller

2011-01-01

the active growth period. Using the smallest (−12.44‰) and the largest (−11.26‰) δ13C measured during 1988 and 2006, estimates of maize-derived C in soil after 18 years ranged from 13.2% to 14.2% of the soil total C. Despite a loss of 31% of the soil C pool under bare fallow, the increase in soil δ13C...

29 CFR 97.44 - Termination for convenience.

Science.gov (United States)

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true Termination for convenience. 97.44 Section 97.44 Labor Office of the Secretary of Labor UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND COOPERATIVE... § 97.44 Termination for convenience. Except as provided in § 97.43 awards may be terminated in whole or...

Structural, magnetic and transport properties of Mn3.1Sn0.9 and Mn3.1Sn0.9N compounds

International Nuclear Information System (INIS)

Feng, W.J.; Li, D.; Ren, W.J.; Li, Y.B.; Li, W.F.; Li, J.; Zhang, Y.Q.; Zhang, Z.D.

2007-01-01

The cubic anti-perovskite Mn 3.1 Sn 0.9 N compound is prepared via nitrogenation of the hexagonal Mn 3.1 Sn 0.9 compound. A magnetic phase diagram of Mn 3.1 Sn 0.9 compound is constructed by analysis of data of its magnetic properties. For Mn 3.1 Sn 0.9 N compound, parasitic ferromagnetism exists in the temperature range of 5-370 K, besides a spin-reorientation at about 280 K. Mn 3.1 Sn 0.9 compound exhibits a metallic conducting behavior, while Mn 3.1 Sn 0.9 N displays a metal-nonmetal transition due to the electron localization caused by the static disorder. The differences of the physical properties between the both compounds, are discussed, in terms of the correlation of the hexagonal DO 19 and the cubic anti-perovskite structures, the reduction of the distances between Mn atoms, and the spin-pairing or charge transfer effect due to the electron donation by N 2p to Mn 3d states after introduction of N atoms into the interstitial sites of Mn 3.1 Sn 0.9 compound

24 CFR 85.44 - Termination for convenience.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Termination for convenience. 85.44 Section 85.44 Housing and Urban Development Office of the Secretary, Department of Housing and Urban... § 85.44 Termination for convenience. Except as provided in § 85.43 awards may be terminated in whole or...

30 CFR 44.9 - Posting of petition.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Posting of petition. 44.9 Section 44.9 Mineral... REQUIREMENTS RULES OF PRACTICE FOR PETITIONS FOR MODIFICATION OF MANDATORY SAFETY STANDARDS General § 44.9 Posting of petition. An operator of a mine for which there is no representative of miners shall post a...

The corticotropin-releasing factor-like diuretic hormone 44 (DH44) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster.

Science.gov (United States)

Cannell, Elizabeth; Dornan, Anthony J; Halberg, Kenneth A; Terhzaz, Selim; Dow, Julian A T; Davies, Shireen-A

2016-06-01

Malpighian tubules are critical organs for epithelial fluid transport and stress tolerance in insects, and are under neuroendocrine control by multiple neuropeptides secreted by identified neurons. Here, we demonstrate roles for CRF-like diuretic hormone 44 (DH44) and Drosophila melanogaster kinin (Drome-kinin, DK) in desiccation and starvation tolerance. Gene expression and labelled DH44 ligand binding data, as well as highly selective knockdowns and/or neuronal ablations of DH44 in neurons of the pars intercerebralis and DH44 receptor (DH44-R2) in Malpighian tubule principal cells, indicate that suppression of DH44 signalling improves desiccation tolerance of the intact fly. Drome-kinin receptor, encoded by the leucokinin receptor gene, LKR, is expressed in DH44 neurons as well as in stellate cells of the Malpighian tubules. LKR knockdown in DH44-expressing neurons reduces Malpighian tubule-specific LKR, suggesting interactions between DH44 and LK signalling pathways. Finally, although a role for DK in desiccation tolerance was not defined, we demonstrate a novel role for Malpighian tubule cell-specific LKR in starvation tolerance. Starvation increases gene expression of epithelial LKR. Also, Malpighian tubule stellate cell-specific knockdown of LKR significantly reduced starvation tolerance, demonstrating a role for neuropeptide signalling during starvation stress. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Pseudomonas fluorescens HK44: Lessons Learned from a Model Whole-Cell Bioreporter with a Broad Application History

Directory of Open Access Journals (Sweden)

Gary S. Sayler

2012-02-01

Full Text Available Initially described in 1990, Pseudomonas fluorescens HK44 served as the first whole-cell bioreporter genetically endowed with a bioluminescent (luxCDABE phenotype directly linked to a catabolic (naphthalene degradative pathway. HK44 was the first genetically engineered microorganism to be released in the field to monitor bioremediation potential. Subsequent to that release, strain HK44 had been introduced into other solids (soils, sands, liquid (water, wastewater, and volatile environments. In these matrices, it has functioned as one of the best characterized chemically-responsive environmental bioreporters and as a model organism for understanding bacterial colonization and transport, cell immobilization strategies, and the kinetics of cellular bioluminescent emission. This review summarizes the characteristics of P. fluorescens HK44 and the extensive range of its applications with special focus on the monitoring of bioremediation processes and biosensing of environmental pollution.

Mednarodni standardi - veličine in enote (ISO 31-0 do 31-13): International standards - quantities and units (ISO 31-0 to 31-13):

OpenAIRE

Glavič, Peter

2002-01-01

In this paper the international standards ISO 31 (Quantities and units) are presented with the following parts: ISO 31-0 (General principles), ISO 31-1 (Space and time), ISO 31-2 (Periodic and related phenomena), ISO 31-3 (Mechanics), ISO 31-4 (Heat), ISO 31-5 (Electricity and magnetism), ISO 31-8 (Physical chemistry and molecular physics), ISO 31-12 (Characteristic numbers)and others. The emphasis is given on the basic principles, which is important for writing of reports, presentations, art...

Department of Energy and Mines, Oil and Gas Revolving Fund financial statements for the year ended March 31, 1993

International Nuclear Information System (INIS)

1993-01-01

The Oil and Gas Revolving Fund of the Saskatchewan Department of Energy and Mines was set up to provide a system of accounting for costs related to regulating and providing certain services to the oil and gas industry. Costs are shared equally by the Department and the industry. The Fund's income from the industry comes from a well levy consisting of annual fees charged to license holders and unit operators of certain types of oil and gas wells. Audited financial statements for the year ending March 31, 1993 are presented

Department of Energy and Mines, Oil and Gas Revolving Fund financial statements for the year ended March 31, 1992

International Nuclear Information System (INIS)

1993-02-01

The Oil and Gas Revolving Fund of the Saskatchewan Department of Energy and Mines was set up to provide a system of accounting for costs related to regulating and providing certain services to the oil and gas industry. Costs are shared equally by the Department and the industry. The Fund's income from the industry comes from a well levy consisting of annual fees charged to license holders and unit operators of certain types of oil and gas wells. Audited financial statements for the year ending March 31, 1992 are presented

46 CFR 44.01-13 - Heavy weather plan.

Science.gov (United States)

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Heavy weather plan. 44.01-13 Section 44.01-13 Shipping... VOYAGES Administration § 44.01-13 Heavy weather plan. (a) Each heavy weather plan under § 44.01-12(b) must... Inspection. Approval of a heavy weather plan is limited to the current hurricane season. (b) The cognizant...

48 CFR 31.205-11 - Depreciation.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Depreciation. 31.205-11....205-11 Depreciation. (a) Depreciation on a contractor's plant, equipment, and other capital facilities... method of depreciation or the class life asset depreciation range system is used, the residual value need...

Isospin excitation of nucleus in 42,44,48Ca (p,n)42,44,48Sc

International Nuclear Information System (INIS)

Suzuki, Keiji

2002-01-01

To obtain information of (p,n) reaction of heavy nucleus in 100 MeV or less, 42,44,48 Ca(p,n) 42,44,48 Sc was observed on the Cyclotron Radio Isotope Center in Tohoku University. The experimental results showed that 7, 8 and 10 spin parities were determined for 42 Sc, 44 Sc and 48 SC, respectively. It was the first determination of one and two negative parity transition of 42 Sc and 48 Sc,respectively, by (p,n) reaction. The full space wave function made by 0f1p shell effective interaction by Richter,et al is good accuracy and reliability. On the (p,n) reaction at E p =35 MeV, the transition matrix elements of 42 Ca, 44 Ca and 48 Ca were derived. On the experiment of 42 Ca(p,n) 42 Sc at E p 2 on energy was agreed with the calculation results by Franey and Love. The nuclear structure of 42 Ca was thought to show more stronger U(4) symmetry, because strong GT transition at T=1 was not observed, which was expected by j-j bonding shell model calculation. (S.Y.)

Recurrent Novae in M31

Czech Academy of Sciences Publication Activity Database

Shafter, A.W.; Henze, M.; Rector, T. A.; Schweizer, F.; Hornoch, Kamil; Orio, M.; Pietsch, W.; Darnley, M.J.; Williams, S.C.; Bode, M.F.; Bryan, J.

2015-01-01

Roč. 216, č. 2 (2015), 34/1-34/35 ISSN 0067-0049 Institutional support: RVO:67985815 Keywords : individual (M31) galaxies * stellar content * cataclysmic variables Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 11.257, year: 2015

26 CFR 31.3231(e)-2 - Contribution base.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 15 2010-04-01 2010-04-01 false Contribution base. 31.3231(e)-2 Section 31.3231... Contribution base. The term compensation does not include any remuneration paid during any calendar year by an employer to an employee for services rendered in excess of the applicable contribution base. For rules...

The discussion of method for survey the radiosensitivity of human glioma cell line SHG-44

International Nuclear Information System (INIS)

Li Li; Xu Changshao; Zhou Juying; Xu Xiaoting; Luo Jialin

2005-01-01

Objective: To investigate if thiazolyl blue colorimetric assay (MTT) and cell counting kit-8 (CCK-8) can replace clone forming assay for survey the radiosensitivity of SHG-44. Methods; Three assays was applied to examine the growth inhibition of human glioma cell line SHG-44 in eight dose groups of 0, 1, 2, 3, 4, 6, 8 and 10 Gy, and statistical research was applied to analyze the correlation between survival fraction and various doses. Results: Dose was associated with survival fraction in these three assays at some range of irradiation doseage (dose≤3 Gy). If out of the range, the relation is poor. CCK-8 has no rather superiority than MTT. Conclusion: By now clone forming assay is still the 'gold standard'. In some cases, MTT and other assays can give us some reference, but these assays still can not replace clone forming assay. (authors)

The thermal comfort and its changes in the 31 provincial capital cities of mainland China in the past 30 years

Science.gov (United States)

Chi, Xiaoli; Li, Rui; Cubasch, Ulrich; Cao, Wenting

2018-04-01

The thermal comfort and its changes in the 31 provincial capital cities of mainland China in the past 30 years were comprehensively evaluated using the Physiologically Equivalent Temperature (PET) and Universal Thermal Climate Index (UTCI) indicators. The PET and UTCI values were highly correlated with each other and presented similar thermal comfort pattern, although their sensitivities might differ slightly. The results showed that these cities covered, respectively, 4-8 and 6-8 thermal comfort classes of the PET and UTCI scale. On the whole, the annual cumulative number of pleasant days was more than 160 days/year. In terms of seasonal variations in thermal comfort conditions, the 31 provincial capital cities in mainland China can be classified into 5 types, which are, respectively, characterized by pleasant summer and severe cold winter (type-I); pleasant spring, autumn, winter, and severe hot summer (type-II); pleasant spring and autumn, slightly pleasant summer, and cold winter (type-III); pleasant spring and autumn, hot stress summer, and slightly cold winter (type-IV); and pleasant spring, summer, autumn, and cool winter (type-V). Type-II cities are rare winter resorts, while type-I cities are natural summer resorts. Type-V cities are the year round pleasant resorts. In the past three decades, the cities in mainland China had experienced increasing pleasant duration in late winter and early spring and intensifying heat stress in summer. The reduction in annual cumulative number of cold stress days in higher latitude/altitude cities outweighed the increase in duration of heat stress in subtropical cities. These may provide some references for urban planning and administration in mainland China.

Electric conduction mechanism of some heterocyclic compounds, 4,4′-bipyridine and indolizine derivatives in thin films

Energy Technology Data Exchange (ETDEWEB)

Danac, Ramona, E-mail: rdanac@uaic.ro [Faculty of Chemistry, Alexandru Ioan Cuza University of Iasi, Bulevardul Carol I, Nr. 11, 700506 Iasi (Romania); Leontie, Liviu, E-mail: lleontie@uaic.ro [Faculty of Physics, Alexandru Ioan Cuza University of Iasi, Bulevardul Carol I, Nr. 11, 700506 Iasi (Romania); Carlescu, Aurelian, E-mail: carlescu_aurelian@yahoo.com [Faculty of Physics, Alexandru Ioan Cuza University of Iasi, Bulevardul Carol I, Nr. 11, 700506 Iasi (Romania); Shova, Sergiu, E-mail: shova@icmpp.ro [Petru Poni Institute of Macromolecular Chemistry, Aleea Grigore Ghica Voda, Nr. 41A, 700487 Iasi (Romania); Tiron, Vasile, E-mail: vasile.tiron@uaic.ro [Faculty of Physics, Alexandru Ioan Cuza University of Iasi, Bulevardul Carol I, Nr. 11, 700506 Iasi (Romania); Rusu, George G., E-mail: rusugxg@uaic.ro [Faculty of Physics, Alexandru Ioan Cuza University of Iasi, Bulevardul Carol I, Nr. 11, 700506 Iasi (Romania); Iacomi, Felicia, E-mail: iacomi@uaic.ro [Faculty of Physics, Alexandru Ioan Cuza University of Iasi, Bulevardul Carol I, Nr. 11, 700506 Iasi (Romania); Gurlui, Silviu, E-mail: sgurlui@uaic.ro [Faculty of Physics, Alexandru Ioan Cuza University of Iasi, Bulevardul Carol I, Nr. 11, 700506 Iasi (Romania); Șușu, Oana, E-mail: oasusu@gmail.com [Faculty of Physics, Alexandru Ioan Cuza University of Iasi, Bulevardul Carol I, Nr. 11, 700506 Iasi (Romania); Rusu, Gheorghe I., E-mail: girusu@uaic.ro [Faculty of Physics, Alexandru Ioan Cuza University of Iasi, Bulevardul Carol I, Nr. 11, 700506 Iasi (Romania)

2016-08-01

Temperature dependence of d. c. electric conductivity of some recently synthesized heterocyclic compounds, 4,4′-bipyridine and indolizine derivatives, in thin films (d = 0.27–0.51 μm) spin-coated from chloroform solutions onto glass, is studied. The investigated compounds are polycrystalline (as shown by X-ray Diffraction analysis) and show typical n-type semiconductor behavior. The activation energy of d. c. electric conduction ranges between 1.55 and 2.33 eV. Some correlations between semiconducting characteristics and essential features of molecular structure of organic compounds have been established. In the higher temperature range (400–520 K), the electronic transport properties in present compounds can be explained in the frame of band gap representation model, while in the lower temperature range (300–350 K), the Mott's variable-range hopping conduction model can be conveniently used. - Highlights: • 4,4′-bipyridine and indolizine derivatives in thin films behave as n-type semiconductors. • The electron transfer is favored by extended conjugation and packing capacity. • The band gap representation is suitable in the higher temperature range. • The Mott's VRH conduction model may be used in the lower temperature range.

Areva as of December 31, 2011; Areva au 31 decembre 2011

Energy Technology Data Exchange (ETDEWEB)

Marie, Patricia; Briand, Pauline; Michaut, Maxime; Scorbiac, Marie de; Repaire, Philippine du

2012-01-26

In 2011, AREVA's consolidated revenue came to 8.872 billion euros, down slightly (-2.6%) compared with 2010 (-1.2% like for like). The decrease in revenue in nuclear operations was partially offset by significant growth in the renewable energies business. Foreign exchange and changes in the scope of consolidation had respectively a negative impact of 113 million euros and 16 million euros over the period. Revenue totaled 2.922 billion euros in the fourth quarter of 2011, stable compared with the fourth quarter of 2010 (-0.5% on a reported basis and -0.5% like for like). Foreign exchange had a negligible impact during the period. Led by nuclear operations, the group's backlog was 45.6 billion euros at December 31, 2011, up 3.1% year on year and 6.7% in relation to September 30, 2011. Order cancellations since Fukushima were limited to 464 million euros as of December 31, 2011. In accordance with the requirements of IFRS 8, AREVA's business segment information is presented for each operating Business Group (BG), which is the level of information examined by the group's governance bodies. Subsequent to the establishment of a subsidiary combining all of the group's mining operations, data for the Mining Business Group are now reported separately from those of the Front End Business Group. Data used for comparisons with 2010 were restated to reflect this new organization. The business segment information therefore corresponds to AREVA's five operating Business Groups: Mining, Front End, Reactors and Services, Back End and Renewable Energies

31 CFR 17.110 - Self-evaluation.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Self-evaluation. 17.110 Section 17... § 17.110 Self-evaluation. (a) The agency shall, by two years after the effective date of this part... handicaps, to participate in the self-evaluation process. (c) The agency shall, until three years following...

31 CFR 10.31 - Negotiation of taxpayer checks.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Negotiation of taxpayer checks. 10.31 Section 10.31 Money and Finance: Treasury Office of the Secretary of the Treasury PRACTICE BEFORE THE INTERNAL REVENUE SERVICE Duties and Restrictions Relating to Practice Before the Internal Revenue Service § 10.31 Negotiation of taxpayer checks. ...

Word Criticality Analysis. MOS: 44B. Skill Levels 1 & 2.

Science.gov (United States)

1981-09-01

IILh2- 51,1 2- 96,1 2- 40.A a- sv;t t. 94.1 2- Soil 2- 12,2 2- list 2-Z5,1 2- 170i 1. 10,1 2- 95.) 2- 19.1 Z- 50.1 1- 411 * 3 Slits 2- 57j,1 0 3...46.1 2- 44,1 2- 43,1 2- 411J 2- . , 1 2- 53,1 2- .2. 2- 51,1 2- Soil 2- 49,1 2- 68.1 2- 47.1 4 APIII’l~if 2-.2 , SATTERIFS Z- 25,1 2 1 6 PIJ$1| " 2...9s1 2 9 1 2 lt 2 71 2 6 o -63,1 2- 94𔃻 2- 00 2- 0,1 2- 95,1 2- 96,1 2-10001 2- 96.1 A USL 2, 91.1 2 59,1 2- 16.1 2- 51 -1- 40,1 2’ 401 2- 31,2 2- 30#2

28 CFR 544.44 - Disciplinary action.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Disciplinary action. 544.44 Section 544... EDUCATION Mandatory English-as-a-Second Language Program (ESL) § 544.44 Disciplinary action. As with any other mandatory programs, such as work assignments, staff may take disciplinary action against an inmate...

31 CFR 31.217 - Confidentiality of information.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Confidentiality of information. 31.217 Section 31.217 Money and Finance: Treasury Office of the Secretary of the Treasury TROUBLED ASSET... from a source other than the retained entity. (b) Prohibitions. The retained entity shall not: (1...

Surgical treatment of bronchiectasis: A review of 20 years of experience

Directory of Open Access Journals (Sweden)

D. Coutinho

2016-03-01

Full Text Available Background: Bronchiectasis is defined as an abnormal and irreversible dilation and distortion of the bronchi, which has numerous causes. Surgical treatment of this disease is usually reserved for focal disease and when the medical treatment is no longer effective. We report our center experience and outcomes in bronchiectasis surgery during the last 20 years. Methods: Between 1994 and 2014, sixty-nine patients underwent surgical resection for bronchiectasis. Patient demographics, presenting symptoms, indications for surgical treatment, type of lung resection, morbidity and mortality, as well as clinical follow-up and outcomes were analyzed. Results: From the 69 patients included, 31 (44.9% were male and 38 (55.1% were female. Surgery was indicated because of unsuccessful medical therapy in 33 patients (47.8%, haemoptysis in 22 patients (31.9%, nondiagnostic lung mass in 9 patients (13.0% and lung abscess in 5 patients (7.3%. The surgical procedures were lobectomy in 45 (65.2% patients, pneumonectomy in 10 (14.5% patients, bilobectomy in 8 (11.6% patients, lobectomy plus segmentectomy in 3 (4.3% patients and only segmentectomy in 3 (4.3% patients. Morbidity rate was 14.5% and there was no perioperative mortality. The follow-up was possible in 60 patients, with an outcome reported as excellent in 44 (73.3% patients, as improved in 11 (18.3% and as unchanged in 5 (8.3%. Conclusion: Although the number of patients with bronchiectasis referred for surgical treatment has decreased, pulmonary resection still plays a significant role. Surgical resection of localized bronchiectasis is a safe procedure with proven improvement of quality of life for the majority of patients. Keywords: Bronchiectasis, Thoracic surgery

Impairments of motor function among children with a familial risk of schizophrenia or bipolar disorder at 7 years old in Denmark

DEFF Research Database (Denmark)

Burton, Birgitte Klee; Thorup, Anne A. E.; Jepsen, Jens Richardt

2017-01-01

BACKGROUND: Owing to the genetic overlap between schizophrenia and bipolar disorder, we aimed to assess domain-specific motor aberrations and disorder specificity among 7-year-old children with a familial risk of schizophrenia or bipolar disorder by comparing children in familial risk groups...... with each other and with children not in these risk groups. METHODS: In the Danish High Risk and Resilience Study, we established a cohort of 7-year-old children with no, one, or two parents with schizophrenia or bipolar disorder in Denmark between Jan 1, 2013, and Jan 31, 2016. We matched children......·19]; p=0·18). Children of parents with bipolar disorder did not show any significant difference in motor performance to children of parents without in the subdomains of manual dexterity (-0·69 [-1·44 to 0·07]; p=0·08), balance (-0·68 [-1·44 to 0·08]; p=0·08), and aiming and catching (-0·36 [-1·03 to 0...

SYNTHESIS AND HEMOLYTIC PROPERTIES OF DERIVATIVES OF 4,4'-DIHYDROXYBIPHENYL – 2,2'-[BIPHENYL-4,4'- DIYLBIS(OXY]BIS[N-(METHYLAMINOALKILACETAMIDES

Directory of Open Access Journals (Sweden)

S. O. Zanoza

2016-04-01

Full Text Available The purpose of this work was synthesis of 4,4’-dihydroxybiphenyl derivatives, namely 2,2’-[biphenyl-4,4’-diylbis(oxy]bis[N-(2-aminoalkylacetamide], study of their hemolytic properties and the effect of the side chain structure on hemolytic properties. 2,2’-[Biphenyl-4,4’-diylbis(oxy]diacetic acid was synthesized by alkylation of 4,4’-dihydroxybiphenyl with methylbromoacetate, followed by alkaline hydrolysis. Chloroanhydride was obtained by treatment of this acid with thionyl chloride. 2,2’-[Biphenyl-4,4’-diylbis(oxy]  bis-[N-(2-aminoalkylacetamides] were synthesized in the biphasic media (dichloromethane/ aqueous sodium carbonate. Structures of synthesized compounds were proved by mass-spectrometryand 1Н NMR. Hemolytic properties were studied using healthy donors’ erythrocytes 0(I/Rh+. The absence of hemolytic properties for obtained compounds was shown, unlike similar 4,4’-aminoalkoxybiphenyls for which a significant hemolysis was shown. Thus, replacement of the ethylene group with amide group in the side chain of 4,4’-bissubstituted biphenyls significantly reduces hemolytic properties.

38 CFR 4.44 - The bones.

Science.gov (United States)

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false The bones. 4.44 Section 4... DISABILITIES Disability Ratings The Musculoskeletal System § 4.44 The bones. The osseous abnormalities incident... convalescence, and progress of recovery with development of permanent residuals. With shortening of a long bone...

Pitavastatin shows greater lipid-lowering efficacy over 12 weeks than pravastatin in elderly patients with primary hypercholesterolaemia or combined (mixed) dyslipidaemia

DEFF Research Database (Denmark)

Stender, Steen; Budinski, Dragos; Gosho, Masahiko

2013-01-01

randomized to six treatment groups (1, 2, or 4 mg pitavastatin vs. 10, 20, or 40 mg pravastatin) in a 12-week multicentre double-blind study. Patients (n = 942; men, 44.3%; Caucasian, 99.3%; mean age, 70 years; age range, 65-89 years) in all groups were well matched for duration of disease and diagnosis......Aim: To compare the safety and efficacy of once-daily pitavastatin (1, 2, and 4 mg) and pravastatin (10, 20, and 40 mg) in elderly patients (≥65 years of age) with primary hypercholesterolaemia or combined (mixed) dyslipidaemia.Design: After a 6-8-week washout/dietary period, patients were.......Results: Mean decreases in low-density lipoprotein cholesterol over 12 weeks were 31.4-44.3% with pitavastatin 1-4 mg and 22.4-34.0% with pravastatin 10-40 mg (p

CNC-milled titanium frameworks supported by implants in the edentulous jaw: a 10-year comparative clinical study.

Science.gov (United States)

Örtorp, Anders; Jemt, Torsten

2012-03-01

No long-term clinical studies covering more than 5 years are available on Computer Numeric Controlled (CNC) milled titanium frameworks. To evaluate and compare the clinical and radiographic performance of implant-supported prostheses provided with CNC titanium frameworks in the edentulous jaw with prostheses with cast gold-alloy frameworks during the first 10 years of function. Altogether, 126 edentulous patients were by random provided with 67 prostheses with titanium frameworks (test) in 23 maxillas and 44 mandibles, and with 62 prostheses with gold-alloy castings (control) in 31 maxillas and 31 mandibles. Clinical and radiographic 10-year data were collected for the groups and statistically compared on patient level. The 10-year prosthesis and implant cumulative survival rate was 95.6% compared with 98.3%, and 95.0% compared with 97.9% for test and control groups, respectively (p > .05). No implants were lost after 5 years of follow-up. Smokers lost more implants than nonsmokers after 5 years of follow-up (p .05), respectively. One prosthesis was lost in each group due to loss of implants, and one prosthesis failed due to framework fracture in the test group. Two metal fractures were registered in each group. More appointments of maintenance were needed for the prostheses in the maxilla compared with those in the mandible (p CNC-milled titanium frameworks are a viable alternative to gold-alloy castings for restoring patients with implant-supported prostheses in the edentulous jaw. © 2009 Wiley Periodicals, Inc.

Ulex Europaeus lectin and anti-CD31 staining in squamous cell carcinoma of the uterine cervix: potential prognostic markers.

Science.gov (United States)

Davidson, B; Goldberg, I; Gotlieb, W H; Lerner-Geva, L; Ben-Baruch, G; Kopolovic, J

1998-07-01

Seventy-five squamous cell carcinomas of the uterine cervix and 10 controls were stained for Ulex Europaeus lectin 1 (UEA-1) and anti-CD31, and the results were analyzed with respect to patient age, clinical stage, tumor grade, and survival during a follow-up period of 1 to 13 years. The patients' mean age at the time of diagnosis was 47.8 years (range, 27 to 83). Seventeen patients died of disease, 2 had disease recurrence, and 51 patients remained free of disease; 5 patients were lost to follow-up. Twenty-eight cases (37.3%) showed focal membranous staining for UEA-1 and 9 cases (12%) showed a diffuse pattern; 38 cases (50.7%) were UEA-1 negative. Poor survival was related to diffuse membranous UEA-1 immunoreactivity (p = 0.02), age (p = 0.014), grade (p = 0.02), and stage (p = 0.0002). CD31-positive neoplastic cells displayed a cytoplasmic pattern. Fifteen cases (20%) had diffuse staining and another 15 (20%) stained focally; 45 cases (60%) were CD31-negative. The adjacent nonneoplastic epithelium and all 10 controls were uniformly negative for CD31. Variable staining of the endocervical epithelium and weak or negative staining of ectocervical epithelium for UEA-1 were observed. However, the epithelium in all controls was negative for UEA-1. Poor survival was related to both focal and diffuse staining for CD31 (p = 0.01 and p = 0.03, respectively). Staining by both UEA-1 and anti-CD31 retained its correlation with survival after exclusion of stage la tumors.

27 CFR 44.227 - Customs procedure.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Customs procedure. 44.227..., WITHOUT PAYMENT OF TAX, OR WITH DRAWBACK OF TAX Drawback of Tax § 44.227 Customs procedure. The customs... having inspected the articles and supervised the lading thereof on the export carrier, the customs...

Incorporation of phosphorus guest ions in the calcium silicate phases of Portland cement from 31P MAS NMR spectroscopy.

Science.gov (United States)

Poulsen, Søren L; Jakobsen, Hans J; Skibsted, Jørgen

2010-06-21

Portland cements may contain small quantities of phosphorus (typically below 0.5 wt % P(2)O(5)), originating from either the raw materials or alternative sources of fuel used to heat the cement kilns. This work reports the first (31)P MAS NMR study of anhydrous and hydrated Portland cements that focuses on the phase and site preferences of the (PO(4))(3-) guest ions in the main clinker phases and hydration products. The observed (31)P chemical shifts (10 to -2 ppm), the (31)P chemical shift anisotropy, and the resemblance of the lineshapes in the (31)P and (29)Si MAS NMR spectra strongly suggest that (PO(4))(3-) units are incorporated in the calcium silicate phases, alite (Ca(3)SiO(5)) and belite (Ca(2)SiO(4)), by substitution for (SiO(4))(4-) tetrahedra. This assignment is further supported by a determination of the spin-lattice relaxation times for (31)P in alite and belite, which exhibit the same ratio as observed for the corresponding (29)Si relaxation times. From simulations of the intensities, observed in inversion-recovery spectra for a white Portland cement, it is deduced that 1.3% and 2.1% of the Si sites in alite and belite, respectively, are replaced by phosphorus. Charge balance may potentially be achieved to some extent by a coupled substitution mechanism where Ca(2+) is replaced by Fe(3+) ions, which may account for the interaction of the (31)P spins with paramagnetic Fe(3+) ions as observed for the ordinary Portland cements. A minor fraction of phosphorus may also be present in the separate phase Ca(3)(PO(4))(2), as indicated by the observation of a narrow resonance at delta((31)P) = 3.0 ppm for two of the studied cements. (31)P{(1)H} CP/MAS NMR spectra following the hydration of a white Portland cement show that the resonances from the hydrous phosphate species fall in the same spectral range as observed for (PO(4))(3-) incorporated in alite. This similarity and the absence of a large (31)P chemical shift ansitropy indicate that the hydrous (PO(4

Psychometric Evaluation of Chinese-Language 44-Item and 10-Item Big Five Personality Inventories, Including Correlations with Chronotype, Mindfulness and Mind Wandering.

Science.gov (United States)

Carciofo, Richard; Yang, Jiaoyan; Song, Nan; Du, Feng; Zhang, Kan

2016-01-01

The 44-item and 10-item Big Five Inventory (BFI) personality scales are widely used, but there is a lack of psychometric data for Chinese versions. Eight surveys (total N = 2,496, aged 18-82), assessed a Chinese-language BFI-44 and/or an independently translated Chinese-language BFI-10. Most BFI-44 items loaded strongly or predominantly on the expected dimension, and values of Cronbach's alpha ranged .698-.807. Test-retest coefficients ranged .694-.770 (BFI-44), and .515-.873 (BFI-10). The BFI-44 and BFI-10 showed good convergent and discriminant correlations, and expected associations with gender (females higher for agreeableness and neuroticism), and age (older age associated with more conscientiousness and agreeableness, and also less neuroticism and openness). Additionally, predicted correlations were found with chronotype (morningness positive with conscientiousness), mindfulness (negative with neuroticism, positive with conscientiousness), and mind wandering/daydreaming frequency (negative with conscientiousness, positive with neuroticism). Exploratory analysis found that the Self-discipline facet of conscientiousness positively correlated with morningness and mindfulness, and negatively correlated with mind wandering/daydreaming frequency. Furthermore, Self-discipline was found to be a mediator in the relationships between chronotype and mindfulness, and chronotype and mind wandering/daydreaming frequency. Overall, the results support the utility of the BFI-44 and BFI-10 for Chinese-language big five personality research.

16 CFR 1502.44 - Review by the courts.

Science.gov (United States)

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Review by the courts. 1502.44 Section 1502.44 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL HAZARDOUS SUBSTANCES ACT REGULATIONS PROCEDURES FOR FORMAL EVIDENTIARY PUBLIC HEARING Judicial Review § 1502.44 Review by the courts...

Post-Closure Inspection Report for the Tonopah Test Range, Nevada, for Calendar Year 2012

Energy Technology Data Exchange (ETDEWEB)

NSTec Environmental Restoration

2013-01-28

This report provides the results of the annual post-closure inspections conducted at the closed Corrective Action Units (CAUs) located on the Tonopah Test Range (TTR), Nevada. This report covers calendar year 2012 and includes inspection and repair activities completed at the following CAUs: · CAU 400: Bomblet Pit and Five Points Landfill (TTR) · CAU 407: Roller Coaster RadSafe Area (TTR) · CAU 424: Area 3 Landfill Complexes (TTR) · CAU 453: Area 9 UXO Landfill (TTR) · CAU 487: Thunderwell Site (TTR)

Breeding Bird Community Continues to Colonize Riparian Buffers Ten Years after Harvest.

Directory of Open Access Journals (Sweden)

Scott F Pearson

Full Text Available Riparian ecosystems integrate aquatic and terrestrial communities and often contain unique assemblages of flora and fauna. Retention of forested buffers along riparian habitats is a commonly employed practice to reduce potential negative effects of land use on aquatic systems. However, very few studies have examined long-term population and community responses to buffers, leading to considerable uncertainty about effectiveness of this practice for achieving conservation and management outcomes. We examined short- (1-2 years and long-term (~10 years avian community responses (occupancy and abundance to riparian buffer prescriptions to clearcut logging silvicultural practices in the Pacific Northwest USA. We used a Before-After-Control-Impact experimental approach and temporally replicated point counts analyzed within a Bayesian framework. Our experimental design consisted of forested control sites with no harvest, sites with relatively narrow (~13 m forested buffers on each side of the stream, and sites with wider (~30 m and more variable width unharvested buffer. Buffer treatments exhibited a 31-44% increase in mean species richness in the post-harvest years, a pattern most evident 10 years post-harvest. Post-harvest, species turnover was much higher on both treatments (63-74% relative to the controls (29%. We did not find evidence of local extinction for any species but found strong evidence (no overlap in 95% credible intervals for an increase in site occupancy on both Narrow (short-term: 7%; long-term 29% and Wide buffers (short-term: 21%; long-term 93% relative to controls after harvest. We did not find a treatment effect on total avian abundance. When assessing relationships between buffer width and site level abundance of four riparian specialists, we did not find strong evidence of reduced abundance in Narrow or Wide buffers. Silviculture regulations in this region dictate average buffer widths on small and large permanent streams that

In situ identification of CD44+/CD24- cancer cells in primary human breast carcinomas.

Directory of Open Access Journals (Sweden)

Giuseppe Perrone

Full Text Available Breast cancer cells with the CD44+/CD24- phenotype have been reported to be tumourigenic due to their enhanced capacity for cancer development and their self-renewal potential. The identification of human tumourigenic breast cancer cells in surgical samples has recently received increased attention due to the implications for prognosis and treatment, although limitations exist in the interpretation of these studies. To better identify the CD44+/CD24- cells in routine surgical specimens, 56 primary breast carcinoma cases were analysed by immunofluorescence and confocal microscopy, and the results were compared using flow cytometry analysis to correlate the amount and distribution of the CD44+/CD24- population with clinicopathological features. Using these methods, we showed that the breast carcinoma cells displayed four distinct sub-populations based on the expression pattern of CD44 and CD24. The CD44+/CD24- cells were found in 91% of breast tumours and constituted an average of 6.12% (range, 0.11%-21.23% of the tumour. A strong correlation was found between the percentage of CD44+/CD24- cells in primary tumours and distant metastasis development (p = 0.0001; in addition, there was an inverse significant association with ER and PGR status (p = 0.002 and p = 0.001, respectively. No relationship was evident with tumour size (T and regional lymph node (N status, differentiation grade, proliferative index or HER2 status. In a multivariate analysis, the percentage of CD44+/CD24- cancer cells was an independent factor related to metastasis development (p = 0.004. Our results indicate that confocal analysis of fluorescence-labelled breast cancer samples obtained at surgery is a reliable method to identify the CD44+/CD24- tumourigenic cell population, allowing for the stratification of breast cancer patients into two groups with substantially different relapse rates on the basis of CD44+/CD24- cell percentage.

30 CFR 44.10 - Filing of petition; service.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Filing of petition; service. 44.10 Section 44... ADMINISTRATIVE REQUIREMENTS RULES OF PRACTICE FOR PETITIONS FOR MODIFICATION OF MANDATORY SAFETY STANDARDS Initial Procedure for Petitions for Modification § 44.10 Filing of petition; service. A petition for...

Neutral coordination polymers based on a metal-mono(dithiolene) complex: synthesis, crystal structure and supramolecular chemistry of [Zn(dmit)(4,4'-bpy)]n, [Zn(dmit)(4,4'-bpe)]n and [Zn(dmit)(bix)]n (4,4'-bpy = 4,4'-bipyridine, 4,4'-bpe = trans-1,2-bis(4-pyridyl)ethene, bix = 1,4-bis(imidazole-1-ylmethyl)-benzene.

Science.gov (United States)

Madhu, Vedichi; Das, Samar K

2011-12-28

This article describes a unique synthetic route that enables a neutral mono(dithiolene)metal unit, {Zn(dmit)}, to link with three different organic molecules, resulting in the isolation of a new class of neutral coordination polymers. The species {Zn(dmit)} coordinates with 4,4'-bipyridine (4,4'-bpy), trans-1,2-bis(4-pyridyl)ethene (4,4'-bpe) and 1,4-bis(imidazole-1-ylmethyl)-benzene (bix) as linkers giving rise to the formation of coordination polymers [Zn(dmit)(4,4'-bpy)](n) (1), [Zn(dmit)(4,4'-bpe)](n) (2) and [Zn(dmit)(bix)](n) (3) respectively. Compounds 1-3 were characterized by elemental analyses, IR, diffuse reflectance and single crystal X-ray diffraction studies. Compounds 1 and 3 crystallize in the monoclinic space group P2(1)/n, whereby compound 2 crystallizes in triclinic space group P1[combining macron]. In the present study, we chose three linkers 4,4'-bpy, 4,4'-bpe and bix (see , respectively, for their structural drawings), that differ in terms of their molecular dimensions. The crystal structures of compounds 1-3 are described here in terms of their supramolecular diversities that include π-π interactions, not only among aromatic stacking (compounds 1 and 3), but also between an aromatic ring and an ethylenic double bond (compound 2). The electronic absorption spectroscopy of compounds 1-3 support these intermolecular π-π interactions. This journal is © The Royal Society of Chemistry 2011

Building a Quality Controlled Database of Meteorological Data from NASA Kennedy Space Center and the United States Air Force's Eastern Range

Science.gov (United States)

Brenton, James C.; Barbre. Robert E., Jr.; Decker, Ryan K.; Orcutt, John M.

2018-01-01

The National Aeronautics and Space Administration's (NASA) Marshall Space Flight Center (MSFC) Natural Environments Branch (EV44) has provided atmospheric databases and analysis in support of space vehicle design and day-of-launch operations for NASA and commercial launch vehicle programs launching from the NASA Kennedy Space Center (KSC), co-located on the United States Air Force's Eastern Range (ER) at the Cape Canaveral Air Force Station. The ER complex is one of the most heavily instrumented sites in the United States with over 31 towers measuring various atmospheric parameters on a continuous basis. An inherent challenge with large sets of data consists of ensuring erroneous data is removed from databases, and thus excluded from launch vehicle design analyses. EV44 has put forth great effort in developing quality control (QC) procedures for individual meteorological instruments, however no standard QC procedures for all databases currently exists resulting in QC databases that have inconsistencies in variables, methodologies, and periods of record. The goal of this activity is to use the previous efforts by EV44 to develop a standardized set of QC procedures from which to build meteorological databases from KSC and the ER, while maintaining open communication with end users from the launch community to develop ways to improve, adapt and grow the QC database. Details of the QC procedures will be described. As the rate of launches increases with additional launch vehicle programs, it is becoming more important that weather databases are continually updated and checked for data quality before use in launch vehicle design and certification analyses.

6 CFR 13.44 - Right to administrative offset.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Right to administrative offset. 13.44 Section 13.44 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.44 Right to administrative offset. The amount of any penalty or assessment that has become...

N = (4,4 Supersymmetry and T-Duality

Directory of Open Access Journals (Sweden)

Malin Göteman

2012-10-01

Full Text Available A sigma model with four-dimensional target space parametrized by chiral and twisted chiral N =(2,2 superfields can be extended to N =(4,4 supersymmetry off-shell, but this is not true for a model of semichiral fields, where the N = (4,4 supersymmetry can only be realized on-shell. The two models can be related to each other by T-duality. In this paper we perform a duality transformation from a chiral and twisted chiral model with off-shell N = (4,4 supersymmetry to a semichiral model. We find that additional non-linear terms must be added to the original transformations to obtain a semichiral model with N =(4,4 supersymmetry, and that the algebra closes on-shell as a direct consequence of the T-duality.

19 CFR 191.44 - Destruction under Customs supervision.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 2 2010-04-01 2010-04-01 false Destruction under Customs supervision. 191.44 Section 191.44 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) DRAWBACK Rejected Merchandise § 191.44 Destruction under Customs supervision. A claimant may destroy merchandise an...

27 CFR 4.4 - Delegations of the Administrator.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Delegations of the Administrator. 4.4 Section 4.4 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF WINE Scope § 4.4 Delegations of the...

Carotid Stenting with Distal Protection in High-Surgical-Risk Patients: One-Year Results of the ASTI Trial

Energy Technology Data Exchange (ETDEWEB)

Bosiers, Marc, E-mail: marc.bosiers@telenet.be [A.Z. Sint-Blasius, Department of Vascular Surgery (Belgium); Scheinert, Dierk, E-mail: dierk.scheinert@gmx.de [Park Hospital, Center for Vascular Medicine-Angiology and Vascular Surgery (Germany); Mathias, Klaus, E-mail: k.mathias@asklepios.com [Klinikum Dortmund GmbH (Germany); Langhoff, Ralf, E-mail: ralf.langhoff@sankt-gertrauden.de [Sankt Gertrauden-Krankenhaus (Germany); Mudra, Harald, E-mail: haraldmudra@aol.com [Klinikum Neuperlach (Germany); Diaz-Cartelle, Juan, E-mail: juan.diazcartelle@bostonscientific.com [One Boston Scientific Place, Boston Scientific Corporation (United States)

2015-04-15

PurposeThis prospective, multicenter, nonrandomized study evaluated the periprocedural and 1-year outcomes in high-surgical-risk patients with carotid artery stenosis treated with the Adapt Carotid Stent plus FilterWire EZ distal protection catheter (Boston Scientific Corporation, Natick, MA).Materials and MethodsThe study enrolled 100 patients (32 symptomatic, 63 asymptomatic, 5 unknown) at high risk for carotid endarterectomy due to prespecified anatomical criteria and/or medical comorbidities. Thirty-day and 1-year follow-up included clinical evaluation, carotid duplex ultrasound, and independent neurologic and NIH stroke scale assessments. One-year endpoints included the composite rate of major adverse events (MAE), defined as death, stroke, and myocardial infarction (MI) and the rates of late ipsilateral stroke (31–365 days), target lesion revascularization, and in-stent restenosis.ResultsOf the 100 enrolled patients, technical success was achieved in 90.9 % (90/99). The 30-day MAE rate (5.1 %) consisted of major stroke (2.0 %) and minor stroke (3.1 %); no deaths or MIs occurred. The 1-year MAE rate (12.2 %) consisted of death, MI, and stroke rates of 4.4, 3.3, and 8.9 %, respectively. Late ipsilateral stroke (31–365 days) rate was 1.1 %. Symptomatic patients had higher rates of death (11.1 vs. 1.7 %) and MI (7.4 vs. 1.7 %), but lower rates of major (7.4 vs. 10.0 %) and minor stroke (0.0 vs. 6.7 %), compared with asymptomatic patients.ConclusionResults through 1 year postprocedure demonstrated that carotid artery stenting with Adapt Carotid Stent and FilterWire EZ is safe and effective in high-risk-surgical patients.

Carotid Stenting with Distal Protection in High-Surgical-Risk Patients: One-Year Results of the ASTI Trial

International Nuclear Information System (INIS)

Bosiers, Marc; Scheinert, Dierk; Mathias, Klaus; Langhoff, Ralf; Mudra, Harald; Diaz-Cartelle, Juan

2015-01-01

PurposeThis prospective, multicenter, nonrandomized study evaluated the periprocedural and 1-year outcomes in high-surgical-risk patients with carotid artery stenosis treated with the Adapt Carotid Stent plus FilterWire EZ distal protection catheter (Boston Scientific Corporation, Natick, MA).Materials and MethodsThe study enrolled 100 patients (32 symptomatic, 63 asymptomatic, 5 unknown) at high risk for carotid endarterectomy due to prespecified anatomical criteria and/or medical comorbidities. Thirty-day and 1-year follow-up included clinical evaluation, carotid duplex ultrasound, and independent neurologic and NIH stroke scale assessments. One-year endpoints included the composite rate of major adverse events (MAE), defined as death, stroke, and myocardial infarction (MI) and the rates of late ipsilateral stroke (31–365 days), target lesion revascularization, and in-stent restenosis.ResultsOf the 100 enrolled patients, technical success was achieved in 90.9 % (90/99). The 30-day MAE rate (5.1 %) consisted of major stroke (2.0 %) and minor stroke (3.1 %); no deaths or MIs occurred. The 1-year MAE rate (12.2 %) consisted of death, MI, and stroke rates of 4.4, 3.3, and 8.9 %, respectively. Late ipsilateral stroke (31–365 days) rate was 1.1 %. Symptomatic patients had higher rates of death (11.1 vs. 1.7 %) and MI (7.4 vs. 1.7 %), but lower rates of major (7.4 vs. 10.0 %) and minor stroke (0.0 vs. 6.7 %), compared with asymptomatic patients.ConclusionResults through 1 year postprocedure demonstrated that carotid artery stenting with Adapt Carotid Stent and FilterWire EZ is safe and effective in high-risk-surgical patients

Functional outcome and health-related quality of life 10 years after moderate-to-severe traumatic brain injury.

Science.gov (United States)

Andelic, N; Hammergren, N; Bautz-Holter, E; Sveen, U; Brunborg, C; Røe, C

2009-07-01

To describe the functional outcome and health-related quality of life (HRQL) 10 years after moderate-to-severe traumatic brain injury (TBI). A retrospective, population-based study of 62 survivors of working-age with moderate-to-severe TBI injured in 1995/1996, and hospitalized at the Trauma Referral Center in Eastern Norway. Functional status was measured by the Glasgow Outcome Scale-Extended (GOS-E). HRQL was assessed by the SF-36 questionnaire. The mean current-age was 40.8 years. The frequency of epilepsy was 19% and the depression rate 31%. A majority had good recovery (48%) or moderate disability (44%). Employment rate was 58%. Functional and employment status were associated with initial injury severity in contrast to HRQL. Study patients had significantly lower scores in all SF-36 dimensions when compared with the general Norwegian population. At 10-years follow-up, our study population is still in their most productive years and affected domains should be considered in long-term follow-up and intervention programs.

31 CFR 360.29 - Adjudication of claims.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Adjudication of claims. 360.29 Section 360.29 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL... the ordinary course of business. (b) Claims filed 10 years after payment. Any claim filed 10 years or...

Classic intrafascial supracervical hysterectomy (CISH): 10-year experience.

Science.gov (United States)

Morrison, John E; Jacobs, Volker R

2006-01-01

We report and review herein our 10-year experience with classic intrafascial supracervical hysterectomy focusing on our long-term experience, evolution of the operative technique, and increased use of this technique. We performed a parallel, observational study with retrospective data to evaluate classic intrafascial supracervical hysterectomy, a laparoscopic hysterectomy technique, at Fayette Medical Center, a community hospital in Northwestern Alabama, USA. Patients comprised a consecutive series of 579 over a 10-year period from November 1992 through November 2002. The classic intrafascial supracervical hysterectomy technique, similar to standard supracervical hysterectomy, leaves the cardinal ligament, uterosacral ligament, vascular supply, and innervation to the upper vagina and cervix intact, but unlike supracervical hysterectomy removes the transition zone and endocervical canal. For 579 patients, the average age was 45.4 years (range, 22 to 92), follow-up was 75.3 months (range, 17 to 137), operating room time was 69 minutes (range, 44 to 370), blood loss was 72 mL (range, 10 to 765), length of hospital stay was 23.2 hours (range, 14 hours to 5 days), time to return to work was 13.2 days (range, 3 to 28). Complications include 11 cervical bleedings, 1 uterine artery bleeding, 1 pelvic hematoma, 1 postoperative ileus, and 16 mucoceles of the cervical stump. Three patients were converted from a laparoscopic to an open procedure (0.52%). Long-term follow-up of up to 137 months shows no adverse events thus far. Classic intrafascial supracervical hysterectomy is a safe procedure with a low short- and long-term complication rate. It has a short recuperation period and high patient satisfaction. It is the procedure of choice when hysterectomy is indicated for benign disease.

Hip strength and range of motion: Normal values from a professional football league.

Science.gov (United States)

Mosler, Andrea B; Crossley, Kay M; Thorborg, Kristian; Whiteley, Rod J; Weir, Adam; Serner, Andreas; Hölmich, Per

2017-04-01

To determine the normal profiles for hip strength and range of motion (ROM) in a professional football league in Qatar, and examine the effect of leg dominance, age, past history of injury, and ethnicity on these profiles. Cross-sectional cohort study. Participants included 394 asymptomatic, male professional football players, aged 18-40 years. Strength was measured using a hand held dynamometer with an eccentric test in side-lying for hip adduction and abduction, and the squeeze test in supine with 45° hip flexion. Range of motion measures included: hip internal and external rotation in 90° flexion, hip IR in prone, bent knee fall out and hip abduction in side-lying. Demographic information was collected and the effect on the profiles was analysed using linear mixed models with repeated measures. Strength values (mean±SD) were: adduction=3.0±0.6Nm/kg, abduction=2.6±0.4Nm/kg, adduction/abduction ratio=1.2±0.2, Squeeze test=3.6±0.8N/kg. Range of motion values: internal rotation in flexion=32±8°, external rotation=38±8°, internal rotation in prone=38±8°, bent knee fall out=13±4.4cm, abduction in side-lying=50±7.3°. Leg dominance had no clinically relevant effect on these profiles. Multivariate analysis demonstrated that age had a minor influence on squeeze strength (-0.03N/kg/year), external rotation (-0.30°/year) and abduction range (-0.19°/year) but past history of injury, and ethnicity did not. Normal values are documented for hip strength and range of motion that can be used as reference profiles in the clinical assessment, screening, and management of professional football players. Leg dominance, recent past injury history and ethnicity do not need to be accounted for when using these profiles for comparison purposes. Copyright © 2016 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

12 CFR 345.44 - Public notice by banks.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Public notice by banks. 345.44 Section 345.44... COMMUNITY REINVESTMENT Records, Reporting, and Disclosure Requirements § 345.44 Public notice by banks. A bank shall provide in the public lobby of its main office and each of its branches the appropriate...

27 CFR 44.102 - Change in trade name.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Change in trade name. 44.102 Section 44.102 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... Warehouse Proprietors Changes in Name § 44.102 Change in trade name. Where there is a change in, or an...

31 CFR 31.212 - Personal conflicts of interest.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Personal conflicts of interest. 31... RELIEF PROGRAM Conflicts of Interest § 31.212 Personal conflicts of interest. (a) Retained entity's... arrangement and key individuals have no personal conflicts of interest unless mitigation measures have...

7 CFR 1412.44 - Notification of base acres.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Notification of base acres. 1412.44 Section 1412.44... through 2012 § 1412.44 Notification of base acres. The operator and owners of record of a farm will be notified in writing of the number of base acres eligible for enrollment in a contract, unless such operator...

Impacts of climate change on range expansion by the mountain pine beetle

Energy Technology Data Exchange (ETDEWEB)

Carroll, A.L.; Taylor, S.W. [Canadian Forest Service, Victoria, BC (Canada). Pacific Forestry Centre; Regniere, J. [Canadian Forest Service, Quebec, PQ (Canada). Laurentian Forestry Centre; Logan, J.A.; Bentz, B.J. [United States Dept. of Agriculture, Logan, UT (United States). Logan Forestry Sciences Laboratory; Powell, J.A. [Utah State Univ., Logan, UT (United States). Dept. of Mathematics and Statistics

2006-07-01

The elevational and latitudinal range of mountain pine beetle (MPB) has been limited by climatic conditions that are currently unfavorable for brood development. This study examined the impact of climatic conditions on the establishment and persistence of MPB using a spatially explicit, climate-driven simulation tool. Historic weather records were also used to create maps of past habitats for MPB in British Columbia. Map overlays were then created to determine if MPB has expanded its range due to changes in the province's climate. The distribution of climatically suitable habitats was examined in 10-year increments. Results of the study showed an increase in benign habitats. MPB populations have expanded into new areas as a result of changes in climate. Additional range expansion for MPB was then assessed using a global circulation model along with a conservative forcing scenario that forecast a doubling of carbon dioxide (CO{sub 2}) by 2050. Weather conditions were then combined with a climatic suitability model in order to examine areas of climatically suitable habitats. It was concluded that continued eastward expansion by MPB is probable. 44 refs., 4 tabs., 7 figs.

Familial partial duplication (1)(p21p31)

Energy Technology Data Exchange (ETDEWEB)

Hoechstetter, L.; Soukup, S.; Schorry, E.K. [Children`s Hospital Research Foundation, Cincinnati, OH (United States)

1995-11-20

A partial duplication (1)(p21p31), resulting from a maternal direct insertion (13,1) (q22p21p31), was found in a 30-year-old woman with mental retardation, cleft palate, and multiple minor anomalies. Two other affected and deceased relatives were presumed to have the same chromosome imbalance. Duplication 1p cases are reviewed. 8 refs., 5 figs., 1 tab.

Spectroscopic quantification of soil phosphorus forms by {sup 31}P-NMR after nine years of organic or mineral fertilization

Energy Technology Data Exchange (ETDEWEB)

Gatiboni, Luciano Colpo, E-mail: gatiboni@cav.udesc.br [Universidade Estadual de Santa Catarina (UDESC), Lages, SC (Brazil); Brunetto, Gustavo; Rheinheimer, Danilo dos Santos; Kaminski, Joao; Flores, Alex Fabiani Claro; Lima, Maria Angelica Silveira; Girotto, Eduardo; Copetti, Andre Carlos Cruz, E-mail: danilo.rheinheimer@pq.cnpq.br, E-mail: joao.kaminski@gmail.com, E-mail: acflores@quimica.ufsm.br, E-mail: masl32003@gmail.com, E-mail: girottosolos@gmail.com, E-mail: andrecopetti@yahoo.com.br [Universidade Federal de Santa Maria (UFSM), RS (Brazil); Pandolfo, Carla Maria; Veiga, Milton, E-mail: pandolfo@epagri.sc.gov.br, E-mail: milveiga@epagri.sc.gov.br [Empresa de Pesquisa Agropecuaria e Extensao Rural de Santa Catarina (EPAGRI), Campos Novos, SC (Brazil)

2013-05-15

Long-standing applications of mineral fertilizers or types of organic wastes such as manure can cause phosphorus (P) accumulation and changes in the accumulated P forms in the soil. The objective of this research was to evaluate the forms of P accumulated in soils treated with mineral fertilizer or different types of manure in a long-term experiment. Soil was sampled from the 0-5 cm layer of plots fertilized with five different nutrient sources for nine years: 1) control without fertilizer; 2) mineral fertilizer at recommended rates for local conditions; 3) 5 t ha{sup -1} year{sup -1} of moist poultry litter; 4) 60 m{sup 3} ha{sup -1} year{sup -1} of liquid cattle manure and 5) 40 m{sup 3} ha{sup -1} year{sup -1} of liquid swine manure. The {sup 31}P-NMR spectra of soil extracts detected the following P compounds: orthophosphate, pyrophosphate, inositol phosphate, glycerophosphate, and DNA. The use of organic or mineral fertilizer over nine years did not change the soil P forms but influenced their concentration. Fertilization with mineral or organic fertilizers stimulated P accumulation in inorganic forms. Highest inositol phosphate levels were observed after fertilization with any kind of manure and highest organic P concentration in glycerophosphate form in after mineral or no fertilization. (author)

Lifetime and g-factor measurements in 44Sc

International Nuclear Information System (INIS)

Chevallier, A.; Chavallier, J.; Gross, J.L.; Haas, B.; Schulz, N.; Styczen, J.; Toulemonde, M.

1975-01-01

The lifetimes of the 235 keV, 2 - state and 350 keV, 4 + state in 44 Sc have been measured via the 44 Ca(p, n) 44 Sc reaction with a pulsed proton beam. The time integral perturbed angular distribution technique with an external field was used to measure the precession angles of the 2 - and 4 + states populated by the 30 Si( 16 O, pnγ) 44 Sc reaction. The following values for the mean-lives and g-factors were obtained: π(2 - ) = 8.83(33) ns, g(2 - ) = 0.30(13) and π(4 + ) = 4.52(27)ns, g(4 + ) = 0.90(12). The results for the 2 - state support a rotational description of the negative parity states in 44 Sc. The magnetic moment of the 4 + state is compared to shell model predictions. (orig.) [de

The Chaotic Long-term X-ray Variability of 4U 1705-44

Science.gov (United States)

Phillipson, R. A.; Boyd, P. T.; Smale, A. P.

2018-04-01

The low-mass X-ray binary 4U1705-44 exhibits dramatic long-term X-ray time variability with a timescale of several hundred days. The All-Sky Monitor (ASM) aboard the Rossi X-ray Timing Explorer (RXTE) and the Japanese Monitor of All-sky X-ray Image (MAXI) aboard the International Space Station together have continuously observed the source from December 1995 through May 2014. The combined ASM-MAXI data provide a continuous time series over fifty times the length of the timescale of interest. Topological analysis can help us identify 'fingerprints' in the phase-space of a system unique to its equations of motion. The Birman-Williams theorem postulates that if such fingerprints are the same between two systems, then their equations of motion must be closely related. The phase-space embedding of the source light curve shows a strong resemblance to the double-welled nonlinear Duffing oscillator. We explore a range of parameters for which the Duffing oscillator closely mirrors the time evolution of 4U1705-44. We extract low period, unstable periodic orbits from the 4U1705-44 and Duffing time series and compare their topological information. The Duffing and 4U1705-44 topological properties are identical, providing strong evidence that they share the same underlying template. This suggests that we can look to the Duffing equation to help guide the development of a physical model to describe the long-term X-ray variability of this and other similarly behaved X-ray binary systems.

HA/CD44 interactions as potential targets for cancer therapy

Science.gov (United States)

Misra, Suniti; Heldin, Paraskevi; Hascall, Vincent C.; Karamanos, Nikos K.; Skandalis, Spyros S.; Markwald, Roger R.; Ghatak, Shibnath

2011-01-01

It is becoming increasingly clear that signals generated in tumor microenvironments are crucial to tumor cell behavior, such as, survival progression, and metastasis. The establishment of these malignant behaviors requires that tumor cells acquire novel adhesion and migration properties to detach from their original sites for localizing into distant organs. CD44, an adhesion/homing molecule is a major receptor for the glycosaminoglycan hyaluronan, which is one of the major components of the tumor extracellular matrix (ECM). CD44, a multi structural and multifunctional molecule, detects changes in ECM components, and thus is well positioned to provide appropriate responses to changes in the microenvironment, i.e. engagement in cell-cell and cell-ECM interactions, cell traffic, lymph node homing, and presentation of growth factors/cytokines/chemokines to co-ordinate signaling events that enable the cell responses that change in the tissue environment. The potential involvement of CD44variants (CD44v), especially CD44v4-v7 and CD44v6-v9 in tumor progression was confirmed for many tumor types in numerous clinical studies. Down regulation of the standard CD44 isoform (CD44s) in colon cancer is postulated to result in increased tumorigenicity. CD44v-specific functions could be due to their higher binding affinity for hyaluronan than CD44s. Alternatively, CD44v-specific functions could be due to differences in associating molecules, which may bind selectively to the CD44v exon. This review summarizes how the interaction between hyaluronan and CD44v can serve as a potential target for cancer therapy, in particular how silencing the CD44v can target multiple metastatic tumors. PMID:21362138

20 CFR 225.44 - When a cost-of-living increase is payable.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false When a cost-of-living increase is payable... RETIREMENT ACT PRIMARY INSURANCE AMOUNT DETERMINATIONS Cost-of-Living Increases § 225.44 When a cost-of-living increase is payable. A cost-of-living increase is payable beginning with December of the year for...

Long-term outcome in patients treated with sirolimus-eluting stents in complex coronary artery lesions: 3-year results of the SCANDSTENT (Stenting Coronary Arteries in Non-Stress/Benestent Disease) trial

DEFF Research Database (Denmark)

Kelbaek, H.; Klovgaard, L.; Helqvist, S.

2008-01-01

data of the long-term outcome of patients with complex coronary artery lesions. METHODS: We randomly assigned 322 patients with total coronary occlusions or lesions located in bifurcations, ostial, or angulated segments of the coronary arteries to have SES or BMS implanted. RESULTS: At 3 years, major...... performed between 1 and 3 years after the index treatment (p = NS). According to revised definitions, stent thrombosis occurred in 5 patients (3.1%) in the SES group and in 7 patients (4.4%) in the BMS group (p = NS); very late stent thrombosis was observed in 4 versus 1 patient. CONCLUSIONS: A continued...

Torsion of normal adnexa in a 31-year-old woman: A case report and literature review

Directory of Open Access Journals (Sweden)

Nao Wakui

2018-01-01

Full Text Available It is known that a large ovarian cyst will likely cause torsion. However, normal adnexal torsion is rare and occurs in premenarchal girls in most cases. This is a case of a reproductive woman. A 31-year-old woman suffering from acute abdominal pain in the lower and right side consulted her gynecologist. The next day she had a computed tomography performed and was suspected of ovarian torsion. She did not have fever, nausea, or leukocytosis, but her abdominal pain persisted. Diagnostic laparoscopy was performed and showed torsion of the right fallopian tube, which was swollen and looked like a hydrosalpinx with a normal ovary. We did detorsion and excision of the right tube. However, pathological findings showed that the right tube was not a hydrosalpinx but was swollen due to blood stasis. We determined that this case was torsion of normal adnexa. In such cases, diagnostic laparoscopy is very effective.

Report and accounts of the United Kingdom Atomic Energy Authority for the year ended 31 March 1988. Revised ed.

International Nuclear Information System (INIS)

1988-08-01

Over the year reviewed, three major changes in the Authority's structure and organisation were made. These are designed to secure a coherent nuclear energy research programme that meets customers needs, to develop new areas of business and to monitor the quality and scientific standards of research within the Authority. The technical report section covers a summary of the 1987-8 position of advanced gas-cooled reactors, pressurized water reactor safety research, the Winfrith reactor, fusion, fuel cycle research, general nuclear safety research, nuclear instrumentation, radiological protection research, safeguards research, underlying research, decommissioning and waste management operations and the fast reactor programme based on the Dounreay prototype fast reactor. Industrial and Environmental technology includes a variety of topics including oil and gas technology and the development of renewable energy sources, especially wind power. The work of each of the Authority's establishments is summarized. There is a separate booklet on the Winfrith research establishment. The accounts for the year to 31 March 1988 are presented. (U.K.)

Early childhood severe scalds in a developing country: A 3-year retrospective study

Directory of Open Access Journals (Sweden)

Pius Agbenorku

2013-12-01

Full Text Available The burns intensive care unit (BICU staff observed an increasing number of pediatric scald burn admissions as a result of increase injuries associated with the scald burns. A retrospective study was conducted to identify scalds demographics, etiologies, and mortality risk factors. This descriptive study comprised a total of 166 patients aged 0-5 years, who were admitted to the BICU of the Reconstructive Plastic Surgery and Burns Unit (RPSBU through the Accident and Emergency (A and E Centre of the Komfo Anokye Teaching Hospital (KATH from May 1 st 2009 to April 30 th 2012. Source of information was the BICU Computerized Database System. Data extracted included demographics as well as treatment methods and outcomes. The study population was 166; 92 (55.4% males and 74 (44.6% females. Scalds admissions were 141 (84.9%; 13 (9.2% of them died, 83 (58.9% discharged, and 45 (31.9% transferred-out to another burn ward and pediatric surgery ward in the hospital. Scald patients' demographics included 78 males (55.3% and 63 females (44.7%; mean age was 2.18 years. Mortality risk factors identified were age <3 years (P = 0.044; scalds from hot water (P = 0.033, total burns surface area >30% (P = 0.017, and multiple body parts affected (P = 0.049. The current study showed age, hot water, and Total Burns Surface Area (TBSA as risk factors of early childhood scalds. Education on scalds prevention targeting mothers/caregivers is needed to create awareness of the frequency, severity, and danger associated with pediatric scalds.

Absent/weak CD44 intensity and positive human papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma indicates a very high survival

International Nuclear Information System (INIS)

Näsman, Anders; Nordfors, Cecilia; Grün, Nathalie; Munck-Wikland, Eva; Ramqvist, Torbjörn; Marklund, Linda; Lindquist, David; Dalianis, Tina

2013-01-01

Patients with human papillomavirus DNA positive (HPV DNA +) oropharyngeal squamous cell carcinoma (OSCC) have better clinical outcome than those with HPV DNA negative (HPV DNA −) OSCC upon intensive oncological treatment. All HPV DNA + OSCC patients may not require intensive treatment, however, but before potentially deintensifying treatment, additional predictive markers are needed. Here, we examined HPV, p16 INK4a , and CD44 in OSCC in correlation to clinical outcome. Pretreatment tumors from 290 OSCC patients, the majority not receiving chemotherapy, were analyzed for HPV DNA by Luminex and for p16 INK4a and CD44 by immunohistochemistry. 225/290 (78%) tumors were HPV DNA + and 211/290 (73%) overexpressed p16 INK4a , which correlated to presence of HPV (P < 0.0001). Presence of HPV DNA, absent/weak CD44 intensity staining correlated to favorable 3-year disease-free survival (DFS) and overall survival (OS) by univariate and multivariate analysis, and likewise for p16 INK4a by univariate analysis. Upon stratification for HPV, HPV DNA + OSCC with absent/weak CD44 intensity presented the significantly best 3-year DFS and OS, with >95% 3-year DFS and OS. Furthermore, in HPV DNA + OSCC, p16 INK4a + overexpression correlated to a favorable 3-year OS. In conclusion, patients with HPV DNA + and absent/weak CD44 intensity OSCC presented the best survival and this marker combination could possibly be used for selecting patients for tailored deintensified treatment in prospective clinical trials. Absence of/weak CD44 or presence of human papillomavirus (HPV) DNA was shown as a favorable prognostic factors in tonsillar and tongue base cancer. Moreover, patients with the combination of absence of/weak CD44 and presence of HPV DNA presented a very favorable outcome. Therefore, we suggest that this marker combination could potentially be used to single out patients with a high survival that could benefit from a de-escalated oncological treatment

Wetting behavior of molten In-Sn alloy on bulk amorphous and crystalline Cu40Zr44Al8Ag8

International Nuclear Information System (INIS)

Ma, G. F.; Zhang, H. F.; Li, H.; Hu, Z. Q.

2007-01-01

Using the sessile-drop method, the wettability of the molten In-Sn alloy on bulk amorphous and crystalline Cu 40 Zr 44 Al 8 Ag 8 alloy was studied at different temperatures. It was found that the equilibrium contact angle of In-Sn alloy melt on bulk amorphous substrate was smaller than that of the crystalline one. An intermetallic compound existed at the interface of In-Sn alloy on amorphous Cu 40 Zr 44 Al 8 Ag 8 , while no intermediate reaction layer was formed at the interface of In-Sn alloy on crystalline Cu 40 Zr 44 Al 8 Ag 8 in the temperature range studied

Arthroscopic surgical treatment of recalcitrant lateral epicondylitis - A series of 47 cases

Directory of Open Access Journals (Sweden)

Alexandre Tadeu do Nascimento

Full Text Available ABSTRACT OBJECTIVE: To evaluate the results of patients undergoing arthroscopic surgical treatment of refractory lateral epicondylitis, identifying poor prognosis factors. METHODS: A retrospective study of 44 patients (47 elbows who underwent arthroscopic debridement of the extensor carpi radialis brevis (ECRB tendon to treat refractory lateral epicondylitis from February 2013 to February 2015, operated by a single surgeon at one center. Patients were assessed by DASH score, visual analog scale of pain (VAS, and ShortForm 36 (SF-36. The mean age at surgery was 44.4 years (32-60. The duration of symptoms prior to the surgery was approximately 2.02 years (range: 6 months to 10 years. Mean follow-up was 18.6 months (range of 6-31.9 . RESULTS: The mean postoperative DASH score was 25.9 points; mean VAS, 1.0 point at rest (all the patients with mild pain and 3.0 points at activity, of which 31 (66% cases presented mild pain, 10 (21% moderate pain, and six (13% severe pain; mean SF-36 score was 62.5. A moderate correlation was observed between duration of pain before surgery and the DASH score with the final functional outcome. No significant complications with the arthroscopic procedure were observed. CONCLUSIONS: Arthroscopic surgical treatment for recalcitrant lateral elbow epicondylitis presented good results, being effective and safe. The shorter the time of pain before surgery and the lower the preoperative DASH score, the better the prognosis.

Arthroscopic surgical treatment of recalcitrant lateral epicondylitis - A series of 47 cases.

Science.gov (United States)

Nascimento, Alexandre Tadeu do; Claudio, Gustavo Kogake

2017-01-01

To evaluate the results of patients undergoing arthroscopic surgical treatment of refractory lateral epicondylitis, identifying poor prognosis factors. A retrospective study of 44 patients (47 elbows) who underwent arthroscopic debridement of the extensor carpi radialis brevis (ECRB) tendon to treat refractory lateral epicondylitis from February 2013 to February 2015, operated by a single surgeon at one center. Patients were assessed by DASH score, visual analog scale of pain (VAS), and ShortForm 36 (SF-36). The mean age at surgery was 44.4 years (32-60). The duration of symptoms prior to the surgery was approximately 2.02 years (range: 6 months to 10 years). Mean follow-up was 18.6 months (range of 6-31.9). The mean postoperative DASH score was 25.9 points; mean VAS, 1.0 point at rest (all the patients with mild pain) and 3.0 points at activity, of which 31 (66%) cases presented mild pain, 10 (21%) moderate pain, and six (13%) severe pain; mean SF-36 score was 62.5. A moderate correlation was observed between duration of pain before surgery and the DASH score with the final functional outcome. No significant complications with the arthroscopic procedure were observed. Arthroscopic surgical treatment for recalcitrant lateral elbow epicondylitis presented good results, being effective and safe. The shorter the time of pain before surgery and the lower the preoperative DASH score, the better the prognosis.

Final Report: Collider Physics, April 1, 1995 - March 31, 1999

International Nuclear Information System (INIS)

White, James T.

1999-01-01

This report summarizes the work done on Grant DE-FG03-95ER40916 over the period April 1, 1995 through March 31, 1999. Detailed progress have been submitted for the years through March 31, 1999. The primary project during this period was the D0 experiment at Fermilab and is discussed first. The last year of the period was an extension to complete the study of laser induced fluorescence in neon. This work is discussed in the section ''Detector R and D''

41 CFR 109-44.702 - Donations to public bodies.

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Donations to public... AND DISPOSAL 44-DONATION OF PERSONAL PROPERTY 44.7-Donations of Property to Public Bodies § 109-44.702 Donations to public bodies. ...

48 CFR 31.205-12 - Economic planning costs.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Economic planning costs... GENERAL CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 31.205-12 Economic planning costs. Economic planning costs are the costs of general long-range...

Recognizing history in range ecology: 100 years of science and management on the Santa Rita Experimental Range

Science.gov (United States)

Nathan F. Sayre

2003-01-01

At the centennial of the Santa Rita Experimental Range, historical analysis is called for on two levels. First, as a major site in the history of range ecology, the Santa Rita illuminates past successes and failures in science and management and the ways in which larger social, economic, and political factors have shaped scientific research. Second, with the turn away...

25 CFR 1000.44 - What happens if there are insufficient funds to meet the Tribal requests for planning/negotiation...

Science.gov (United States)

2010-04-01

... 25 Indians 2 2010-04-01 2010-04-01 false What happens if there are insufficient funds to meet the Tribal requests for planning/negotiation grants in any given year? 1000.44 Section 1000.44 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ANNUAL FUNDING AGREEMENTS UNDER THE TRIBAL SELF-GOVERNMENT ACT AMENDMENT...

Radioecology of natural systems. Three year summary report, May 1, 1974--July 31, 1977

International Nuclear Information System (INIS)

Whicker, F.W.

1977-01-01

This report is intended to provide a general summary of the progress and findings of studies during the period May 1, 1974 through July 31, 1977 on the distribution, transport, characterization and ecological consequences of plutonium in the terrestrial environs of the Rocky Flats nuclear weapons plant near Denver, Colorado. The contamination of a portion of the terrestrial environs of Rocky Flats with substantial quantities of plutonium provided the opportunity to search for possible ecological effects resulting from the presence of the element. Comparisons were made of various biological measurements and pathological data between ecologically similar study areas of widely varying plutonium levels. Soil in the principal study areas ranged from 100 to over 20,000 dpm 239 Pu/g in the upper 3 cm (2 to 400 μCi/m 2 ). In addition, comparative data were obtained from control areas, containing only world-wide fallout plutonium of the order of 0.1 dpm/g (0.002 μCi/m 2 ). Biological measurements such as vegetation community structure and biomass; litter mass; arthropod community structure and biomass; and small mammal species occurrence, population density, biomass, reproduction, and physical size of whole carcass and organs were made. In addition, pathological examinations of small mammals, including x-ray for skeletal sarcomas, microscopy for lung tumors, and necropsy for general pathology and parasite occurrence were carried out. While minor differences in certain biological attributes between study areas were observed, none could be related to plutonium levels

[α/Fe] ABUNDANCES OF FOUR OUTER M31 HALO STARS

International Nuclear Information System (INIS)

Vargas, Luis C.; Geha, Marla; Tollerud, Erik J.; Gilbert, Karoline M.; Kirby, Evan N.; Guhathakurta, Puragra

2014-01-01

We present alpha element to iron abundance ratios, [α/Fe], for four stars in the outer stellar halo of the Andromeda Galaxy (M31). The stars were identified as high-likelihood field halo stars by Gilbert et al. and lie at projected distances between 70 and 140 kpc from M31's center. These are the first alpha abundances measured for a halo star in a galaxy beyond the Milky Way. The stars range in metallicity between [Fe/H] = –2.2 and [Fe/H] = –1.4. The sample's average [α/Fe] ratio is +0.20 ± 0.20. The best-fit average value is elevated above solar, which is consistent with rapid chemical enrichment from Type II supernovae. The mean [α/Fe] ratio of our M31 outer halo sample agrees (within the uncertainties) with that of Milky Way inner/outer halo stars that have a comparable range of [Fe/H

40 CFR 406.44 - Pretreatment standards for existing sources.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Pretreatment standards for existing sources. 406.44 Section 406.44 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... § 406.44 Pretreatment standards for existing sources. Any existing source subject to this subpart that...

26 CFR 1.1502-44 - Percentage depletion for independent producers and royalty owners.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 12 2010-04-01 2010-04-01 false Percentage depletion for independent producers...-44 Percentage depletion for independent producers and royalty owners. (a) In general. The sum of the percentage depletion deductions for the taxable year for all oil or gas property owned by all members, plus...

The Ahmed Versus Baerveldt Study: Five-Year Treatment Outcomes.

Science.gov (United States)

Christakis, Panos G; Kalenak, Jeffrey W; Tsai, James C; Zurakowski, David; Kammer, Jeffrey A; Harasymowycz, Paul J; Mura, Juan J; Cantor, Louis B; Ahmed, Iqbal I K

2016-10-01

To compare 2 frequently used aqueous shunts for the treatment of glaucoma. International, multicenter, randomized trial. Patients aged 18 years or older with uncontrolled glaucoma despite maximum tolerated medical therapy, many of whom had failed or were at high risk of failing trabeculectomy. Eligible patients were randomized to receive an Ahmed-FP7 valve implant (New World Medical, Inc, Rancho Cucamonga, CA) or a Baerveldt-350 implant (Abbott Medical Optics, Inc, Santa Ana, CA) using a standardized surgical technique. The primary outcome was failure, defined as intraocular pressure (IOP) outside the target range (5-18 mmHg) or reduced glaucoma surgery. Secondary outcomes measures included IOP, medication use, visual acuity, complications, and interventions. A total of 238 patients were randomized; 124 received the Ahmed-FP7 implant, and 114 received the Baerveldt-350 implant. Baseline characteristics were similar between groups. Mean preoperative IOP was 31.4±10.8 mmHg on 3.1±1.0 glaucoma medications. At 5 years, the cumulative failure rate was 53% in the Ahmed group and 40% in the Baerveldt group (P = 0.04). The main reason for failure in both groups was high IOP, and the cumulative de novo glaucoma reoperation rate was 18% in the Ahmed group and 11% in the Baerveldt group (P = 0.22). Hypotony resulted in failure in 5 patients (4%) in the Baerveldt group compared with none in the Ahmed group (P = 0.02). Mean IOP was 16.6±5.9 mmHg in the Ahmed group (47% reduction) and 13.6±5.0 mmHg in the Baerveldt group (57% reduction, P = 0.001). Mean medication use was 1.8±1.5 mmHg in the Ahmed group (44% reduction) and 1.2±1.3 mmHg in the Baerveldt group (61% reduction, P = 0.03). The 2 groups had similar complication rates (Ahmed 63%, Baerveldt 69%) and intervention rates (Ahmed 41%, Baerveldt 41%). Most complications were transient, and most interventions were slit-lamp procedures. Both implants were effective in reducing IOP and the need for glaucoma

2011 NASA Range Safety Annual Report

Science.gov (United States)

Dumont, Alan G.

2012-01-01

Welcome to the 2011 edition of the NASA Range Safety Annual Report. Funded by NASA Headquarters, this report provides a NASA Range Safety overview for current and potential range users. As is typical with odd year editions, this is an abbreviated Range Safety Annual Report providing updates and links to full articles from the previous year's report. It also provides more complete articles covering new subject areas, summaries of various NASA Range Safety Program activities conducted during the past year, and information on several projects that may have a profound impact on the way business will be done in the future. Specific topics discussed and updated in the 2011 NASA Range Safety Annual Report include a program overview and 2011 highlights; Range Safety Training; Range Safety Policy revision; Independent Assessments; Support to Program Operations at all ranges conducting NASA launch/flight operations; a continuing overview of emerging range safety-related technologies; and status reports from all of the NASA Centers that have Range Safety responsibilities. Every effort has been made to include the most current information available. We recommend this report be used only for guidance and that the validity and accuracy of all articles be verified for updates. Once again the web-based format was used to present the annual report. We continually receive positive feedback on the web-based edition and hope you enjoy this year's product as well. As is the case each year, contributors to this report are too numerous to mention, but we thank individuals from the NASA Centers, the Department of Defense, and civilian organizations for their contributions. In conclusion, it has been a busy and productive year. I'd like to extend a personal Thank You to everyone who contributed to make this year a successful one, and I look forward to working with all of you in the upcoming year.

Lifetime of {sup 44}Ti as probe for supernova models

Energy Technology Data Exchange (ETDEWEB)

Goerres, J; Meissner, J; Schatz, H; Stech, E; Tischhauser, P; Wiescher, M [Univ. of Notre Dame, Notre Dame, IN (United States); Bazin, D; Harkewicz, R; Hellstroem, M; Sherrill, B; Steiner, M [Michigan State Univ., East Lansing, MI (United States); Boyd, R N [Ohio State Univ., Columbus, OH (United States); Buchmann, L [TRIUMF, Vancouver, BC (Canada); Hartmann, D H [Clemson Univ., Clemson, SC (United States); Hinnefeld, J D [Indiana Univ. South Bend, South Bend, IN (United States)

1998-06-01

The recent observation of {sup 44}Ti radioactivity in the supernova remnant Cassiopeia A with the Compton Gamma Ray Observatory allows the determination of the absolute amount of {sup 44}Ti. This provides a test for current supernova models. The main uncertainty is the lifetime of {sup 44}Ti. We report a new measurement of the lifetime of {sup 44}Ti applying a novel technique. A mixed radioactive beam containing {sup 44}Ti as well as {sup 22}Na was implanted and the resulting {gamma}-activity was measured. This allowed the determination of the lifetime of {sup 44}Ti relative to the lifetime of {sup 22}Na, {tau} = (87.0 {+-} 1.9) y. With this lifetime, the {sup 44}Ti abundance agrees with theoretical predictions within the remaining observational uncertainties. (orig.)

Six Years in the Life of a Mother Bear - The Longest Continuous Heart Rate Recordings from a Free-Ranging Mammal

Science.gov (United States)

Laske, Timothy G.; Iaizzo, Paul A.; Garshelis, David L.

2017-01-01

Physiological monitoring of free-ranging wild animals is providing new insights into their adaptations to a changing environment. American black bears (Ursus americanus) are highly adaptable mammals, spending up to half the year hibernating, and the remainder of the year attempting to gain weight on a landscape with foods that vary seasonally and year to year. We recorded heart rate (HR) and corresponding activity of an adult female black bear over the course of six years, using an implanted monitor. Despite yearly differences in food, and an every-other year reproductive cycle, this bear exhibited remarkable consistency in HR and activity. HR increased for 12 weeks in spring, from minimal hibernation levels (mean 20-25 beats/minute [bpm]; min 10 bpm) to summer active levels (July daytime: mean 95 bpm). Timing was delayed following one cold winter. In August the bear switched from primarily diurnal to nocturnal, coincident with the availability of baits set by legal hunters. Activity in autumn was higher when the bear was with cubs. Birthing of cubs in January was identified by a transient increase in HR and activity. Long-term physiological and behavioral monitoring is valuable for understanding adaptations of free-ranging animals to climate change, food availability, and human-related stressors.

Gated in vivo examination of cardiac metabolites with 31P nuclear magnetic resonance

International Nuclear Information System (INIS)

Kantor, H.L.; Briggs, R.W.; Metz, K.R.; Balaban, R.S.

1986-01-01

Phosphorus-31 nuclear magnetic resonance ( 31 P NMR) spectroscopy was used to study the temporal aspects of metabolism of canine heart in vivo. An NMR catheter coil was passed through the jugular vein of a dog into the apex of the right ventricle and spectra were recorded at four points in the cardiac cycle by triggering from the blood pressure trace of the animal. The 31 P spin-lattice relaxation times of phosphocreatine (PC) and the γ - ,α - , and β-phosphates of ATP at 1.89 Tesla are 4.4, 1.8, 1.7, and 1.6 s, respectively. The ratio of PC to ATP is 2.0. No changes in PC/ATP were noted in any of the four portions of the cardiac cycle examined, and difference spectra exhibited no observable signals, in contrast to previously reported results for glucose-perfused rat hearts. On the assumption that intracellular pH and the total creatine pool were constant, the expression for the creatine kinase reaction was used to deduce that free ADP concentrations were invariant throughout the cardiac cycle. This is in apparent disagreement with the proposed regulatory role for ADP in heart oxidative phosphorylation

Beta decay of 31,32Na and 31Mg

International Nuclear Information System (INIS)

Klotz, G.; Baumann, P.; Bounajma, M.; Huck, A.; Knipper, A.; Walter, G.; Poves, A.; Retamosa, J.

1993-01-01

31,32 Na and 31 Mg beta decays were studied at the CERN on-line mass separator ISOLDE by gamma, gamma-gamma and neutron-gamma measurements. In the 31 Na decay, the assignment of previously reported γ transitions and the observation of a new level at 3760 keV lead to a revised decay scheme. In the 31 Mg → 31 Al decay, a new decay scheme involves ten β branches and three states are reported for the first time. New spectroscopic results have been obtained in the 32 Na β - decay. A previously non-interpreted 1436 keV γ ray is now assigned in the 32 Mg scheme. (author) 33 refs., 16 figs., 12 tabs

31 CFR 356.31 - How does the STRIPS program work?

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false How does the STRIPS program work? 356.31 Section 356.31 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued...) Miscellaneous Provisions § 356.31 How does the STRIPS program work? (a) General. Notes or bonds may be “stripped...

30 CFR 47.44 - Temporary, portable containers.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Temporary, portable containers. 47.44 Section... TRAINING HAZARD COMMUNICATION (HazCom) Container Labels and Other Forms of Warning § 47.44 Temporary, portable containers. (a) The operator does not have to label a temporary, portable container if he or she...

36 CFR 1207.44 - Termination for convenience.

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Termination for convenience. 1207.44 Section 1207.44 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... Termination for convenience. Except as provided in § 1207.43 awards may be terminated in whole or in part only...

15 CFR 30.41-30.44 - [Reserved

Science.gov (United States)

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false [Reserved] 30.41-30.44 Section 30.41-30.44 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade BUREAU OF THE CENSUS, DEPARTMENT OF COMMERCE FOREIGN TRADE REGULATIONS Exemptions From the Requirements for the Filing...

Application of electrospray mass spectrometry to the characterization of recombinant proteins up to 44 kDa

NARCIS (Netherlands)

Van Dorsselaer, A.; Bitsch, F.; Green, B.; Jarvis, S.; Lepage, P.; Bischoff, Rainer; Kolbe, V.J.; Roitsch, C.

1990-01-01

Mass measurement by electrospray mass spectrometry (ESMS) is used as a rapid preliminary verification of the identity of various recombinant proteins ranging from 7 to 44 kDa with an accuracy of 0.01-0.03%. ESMS not only improves the speed but also the reliability of the protein structure

Effects of 31 FDA approved small-molecule kinase inhibitors on isolated rat liver mitochondria.

Science.gov (United States)

Zhang, Jun; Salminen, Alec; Yang, Xi; Luo, Yong; Wu, Qiangen; White, Matthew; Greenhaw, James; Ren, Lijun; Bryant, Matthew; Salminen, William; Papoian, Thomas; Mattes, William; Shi, Qiang

2017-08-01

The FDA has approved 31 small-molecule kinase inhibitors (KIs) for human use as of November 2016, with six having black box warnings for hepatotoxicity (BBW-H) in product labeling. The precise mechanisms and risk factors for KI-induced hepatotoxicity are poorly understood. Here, the 31 KIs were tested in isolated rat liver mitochondria, an in vitro system recently proposed to be a useful tool to predict drug-induced hepatotoxicity in humans. The KIs were incubated with mitochondria or submitochondrial particles at concentrations ranging from therapeutic maximal blood concentrations (Cmax) levels to 100-fold Cmax levels. Ten endpoints were measured, including oxygen consumption rate, inner membrane potential, cytochrome c release, swelling, reactive oxygen species, and individual respiratory chain complex (I-V) activities. Of the 31 KIs examined only three including sorafenib, regorafenib and pazopanib, all of which are hepatotoxic, caused significant mitochondrial toxicity at concentrations equal to the Cmax, indicating that mitochondrial toxicity likely contributes to the pathogenesis of hepatotoxicity associated with these KIs. At concentrations equal to 100-fold Cmax, 18 KIs were found to be toxic to mitochondria, and among six KIs with BBW-H, mitochondrial injury was induced by regorafenib, lapatinib, idelalisib, and pazopanib, but not ponatinib, or sunitinib. Mitochondrial liability at 100-fold Cmax had a positive predictive power (PPV) of 72% and negative predictive power (NPV) of 33% in predicting human KI hepatotoxicity as defined by product labeling, with the sensitivity and specificity being 62% and 44%, respectively. Similar predictive power was obtained using the criterion of Cmax ≥1.1 µM or daily dose ≥100 mg. Mitochondrial liability at 1-2.5-fold Cmax showed a 100% PPV and specificity, though the NPV and sensitivity were 32% and 14%, respectively. These data provide novel mechanistic insights into KI hepatotoxicity and indicate that

Behaviour of some biopsychosocial factors in the elderly of 90 years old and more.

Directory of Open Access Journals (Sweden)

Damaris Rubido Gómez

2011-09-01

Full Text Available Aging is a universal process that seems to affect all human beings, which is understood as a succession of morphological, physiological and phychological modifications with an irreversible character. A descriptive investigation was done with the objective of identifying the behaviour of some biopsychosocial factors in elder people of 90 years old and more in the dispensaries 44,45,and 49 of the policlinic 2 “Arcelio Suérez Bernal from Jatibonico municipality from January 1st ,2007 to december 31 st ,2008.The sample was conformed by 23 long lived that fulfilled with the inclusion criteria. Different variables were used like:sex, age, autovalidism, food, toxic habits, assossiated deseases and principal plans and projects. Female sex prevailed (69,6%, the 90-94years old group, coffe as risk factor (56,5 %, hip break (39,1% and the autovalidism in the way (86,9%.It was found these elderly get old in a best way because they were physical and social active.

38 CFR 43.44 - Termination for convenience.

Science.gov (United States)

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Termination for convenience. 43.44 Section 43.44 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS... convenience. Except as provided in § 43.43 awards may be terminated in whole or in part only as follows: (a...

7 CFR 3016.44 - Termination for convenience.

Science.gov (United States)

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Termination for convenience. 3016.44 Section 3016.44 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF THE CHIEF FINANCIAL OFFICER... Termination for convenience. Except as provided in § 3016.43 awards may be terminated in whole or in part only...

Correlation of shoulder range of motion limitations at discharge with limitations in activities and participation one year later in persons with spinal cord injury.

Science.gov (United States)

Eriks-Hoogland, Inge E; de Groot, Sonja; Post, Marcel W M; van der Woude, Lucas H V

2011-02-01

To study the correlation between limited shoulder range of motion in persons with spinal cord injury at discharge and the performance of activities, wheeling performance, transfers and participation one year later. Multicentre prospective cohort study. A total of 146 newly injured subjects with spinal cord injury. Shoulder range of motion was measured at discharge. One year later, Functional Independence Measure (FIM), transfer ability, wheelchair circuit and Physical Activity Scale for Individuals with Physical Disabilities (PASIPD) were assessed. Corrections were made for possible confounding factors (age, gender, level and completeness of injury, time since injury and shoulder pain). All subjects with limited shoulder range of motion at discharge had a lower FIM motor score and were less likely (total group 5 times, and subjects with tetraplegia 10 times less likely) to be able to perform an independent transfer one year later. Subjects with limited shoulder range of motion in the total group needed more time to complete the wheelchair circuit. No significant associations with the PASIPD were found in either group. Persons with spinal cord injury and limited shoulder range of motion at discharge are more limited in their activities one year later than those without limited shoulder range of motion.

Post-Closure Inspection Report for the Tonopah Test Range, Nevada, For Calendar Year 2010

International Nuclear Information System (INIS)

2011-01-01

This report provides the results of the annual post-closure inspections conducted at the closed Corrective Action Units (CAUs) located on the Tonopah Test Range (TTR), Nevada. This report covers calendar year 2010 and includes inspection and repair activities completed at the following seven CAUs: (1) CAU 400: Bomblet Pit and Five Points Landfill (TTR); (2) CAU 407: Roller Coaster RadSafe Area (TTR); (3) CAU 424: Area 3 Landfill Complexes (TTR); (4) CAU 426: Cactus Spring Waste Trenches (TTR); (5) CAU 453: Area 9 UXO Landfill (TTR); (6) CAU 484: Surface Debris, Waste Sites, and Burn Area (TTR); and (7) CAU 487: Thunderwell Site (TTR).

27 CFR 44.61 - Removals, withdrawals, and shipments authorized.

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2010-04-01

... payment of tax, for direct exportation or for delivery for subsequent exportation, in accordance with the... shipments authorized. 44.61 Section 44.61 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND... CIGARETTE PAPERS AND TUBES, WITHOUT PAYMENT OF TAX, OR WITH DRAWBACK OF TAX General § 44.61 Removals...

The Risk of Radiation-Induced Tumors or Malignant Transformation After Single-Fraction Intracranial Radiosurgery: Results Based on a 25-Year Experience

Energy Technology Data Exchange (ETDEWEB)

Pollock, Bruce E., E-mail: pollock.bruce@mayo.edu [Department of Neurological Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota (United States); Department of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota (United States); Link, Michael J. [Department of Neurological Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota (United States); Department of Otorhinolaryngology, Mayo Clinic College of Medicine, Rochester, Minnesota (United States); Stafford, Scott L. [Department of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota (United States); Parney, Ian F. [Department of Neurological Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota (United States); Garces, Yolanda I.; Foote, Robert L. [Department of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota (United States)

2017-04-01

Purpose: To determine the risk of radiation-induced tumors or malignant transformation after single-fraction intracranial stereotactic radiosurgery (SRS). Methods and Materials: We performed a retrospective review of 1837 patients who received single-fraction SRS for arteriovenous malformation or benign tumor (meningioma, vestibular schwannoma, pituitary adenoma, glomus tumor) at a single center between 1990 and 2009. Patients were excluded if they refused research authorization (n=31), had a genetic predisposition to tumor development (n=84), received prior or concurrent radiation therapy (n=79), or had less than 5 years of imaging follow-up after SRS (n=501). The median imaging follow-up period for the remaining 1142 patients was 9.0 years (range, 5-24.9 years). Results: No radiation-induced tumors were identified in 11,264 patient-years of follow-up after SRS. The risk of a radiation-induced tumor developing after SRS was 0.0% at 5 years (95% confidence interval [CI], 0.0%-0.4%), 0.0% at 10 years (95% CI, 0.0%-0.9%), and 0.0% at 15 years (95% CI, 0.0%-2.8%). Malignant transformation occurred in 7 of 316 meningioma patients (2.2%) and 1 of 358 vestibular schwannoma patients (0.3%) at a median of 4.9 years (range, 2.8-13.8 years) after SRS. No cases of malignant transformation were noted in patients with pituitary adenomas (n=188) or glomus tumors (n=47). The 5-, 10-, and 15-year risk of malignant transformation was 0.5% (95% CI, 0.0%-0.9%), 0.8% (95% CI, 0.0%-1.8%), and 2.4% (95% CI, 0.0%-5.5%), respectively. Patients who underwent prior resection (hazard ratio, 14.56; 95% CI, 1.79-118.33; P=.01) and who had meningioma pathology (hazard ratio, 11.72; 95% CI, 1.44-96.15; P=.02) were at increased risk of malignant transformation. Conclusions: The risk of radiation-induced tumors or malignant transformation after SRS is very low and should not be used as a justification for choosing alternative treatment approaches (surgical resection, observation) over SRS

The Risk of Radiation-Induced Tumors or Malignant Transformation After Single-Fraction Intracranial Radiosurgery: Results Based on a 25-Year Experience

International Nuclear Information System (INIS)

Pollock, Bruce E.; Link, Michael J.; Stafford, Scott L.; Parney, Ian F.; Garces, Yolanda I.; Foote, Robert L.

2017-01-01

Purpose: To determine the risk of radiation-induced tumors or malignant transformation after single-fraction intracranial stereotactic radiosurgery (SRS). Methods and Materials: We performed a retrospective review of 1837 patients who received single-fraction SRS for arteriovenous malformation or benign tumor (meningioma, vestibular schwannoma, pituitary adenoma, glomus tumor) at a single center between 1990 and 2009. Patients were excluded if they refused research authorization (n=31), had a genetic predisposition to tumor development (n=84), received prior or concurrent radiation therapy (n=79), or had less than 5 years of imaging follow-up after SRS (n=501). The median imaging follow-up period for the remaining 1142 patients was 9.0 years (range, 5-24.9 years). Results: No radiation-induced tumors were identified in 11,264 patient-years of follow-up after SRS. The risk of a radiation-induced tumor developing after SRS was 0.0% at 5 years (95% confidence interval [CI], 0.0%-0.4%), 0.0% at 10 years (95% CI, 0.0%-0.9%), and 0.0% at 15 years (95% CI, 0.0%-2.8%). Malignant transformation occurred in 7 of 316 meningioma patients (2.2%) and 1 of 358 vestibular schwannoma patients (0.3%) at a median of 4.9 years (range, 2.8-13.8 years) after SRS. No cases of malignant transformation were noted in patients with pituitary adenomas (n=188) or glomus tumors (n=47). The 5-, 10-, and 15-year risk of malignant transformation was 0.5% (95% CI, 0.0%-0.9%), 0.8% (95% CI, 0.0%-1.8%), and 2.4% (95% CI, 0.0%-5.5%), respectively. Patients who underwent prior resection (hazard ratio, 14.56; 95% CI, 1.79-118.33; P=.01) and who had meningioma pathology (hazard ratio, 11.72; 95% CI, 1.44-96.15; P=.02) were at increased risk of malignant transformation. Conclusions: The risk of radiation-induced tumors or malignant transformation after SRS is very low and should not be used as a justification for choosing alternative treatment approaches (surgical resection, observation) over SRS

36 CFR 51.44 - How will the Director determine if a concessioner was satisfactory for purposes of a right of...

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2010-07-01

... determine if a concessioner was satisfactory for purposes of a right of preference? 51.44 Section 51.44... satisfactory for purposes of a right of preference? To be a satisfactory concessioner for the purposes of a... concessioner made subsequent to May 17, 2000 are less than satisfactory for any two or more years of operation...

21 CFR 21.44 - Verification of identity.

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2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Verification of identity. 21.44 Section 21.44 Food... Verification of identity. (a) An individual seeking access to records in a Privacy Act Record System may be... identity. The identification required shall be suitable considering the nature of the records sought. No...

Clinical 3-year follow-up of uterine fibroid embolization

International Nuclear Information System (INIS)

Radeleff, B.A.; Satzl, S.; Eiers, M.; Fechtner, K.; Hakim, A.; Kauffmann, G.W.; Richter, G.M.; Rimbach, S.

2007-01-01

Purpose: The purpose of this study was to evaluate the clinical long-term success of uterine artery embolization (UAE) in patients with symptomatic fibroids using spherical particles (Embosphere). Materials and Methods: 34 consecutive patients treated with UAE were initially enrolled in the study which had the following study goals (1) 1-year follow-up MRI evaluation of the fibroid behavior and (2) clinical long-term success due to standardized assessment of the main fibroid-related symptoms (hypermenorrhoea, dysmenorrhoea and dysuria) of the patients' individual overall health status and their therapy satisfaction at 1-year, 2- year and 3-year intervals after UAE. Results: Technical success was achieved in all procedures. Four patients had to be excluded from the long-term evaluation schedule: one because of a hysterectomy due to bleeding after 6 weeks, 3 patients were not available for the designated minimum follow-up interval. The preinterventional severe hypermenorrhoea (n = 27) with a score of 4.4 ± 0.7 (5 = extreme menstrual bleeding) decreased after one year to 2.1 ± 0.5 (p = 0.0001), after two years to 1.7 ± 0.5 (p = 0.0042) and after three years to 1.3 ± 0.6 (p = 0.0001). The preinterventional dysmenorrhoea (n = 15) with a score of 3.1 ± 1.5 (3 = distinctly increased dysmenorrhoea) decreased after one year to 1.1 ± 0.3 (p = 0.0001), after two years to 1.2 ± 0.2 and after three years to 1.2 ± 0.4 (p = 0.148). The pretreatment dysuria (n = 12) with a preinterventional score of 3.1 ± 1.5 (3 = distinctly increased dysuria) decreased after one year to 1.1 ± 0.3 (p 0.0069) and remained after two years at 1.1 ± 0.2 and after three years at 1.2 ± 0.4 (p = 0.905). The initial overall health status was 54.7 ± 20.1 (maximal value 100). After one year it rose to 90.5 ± 15.4 (p = 0.0001), was 91.8 ± 5.6 after two years and was 91.3 ± 8.5 (p = 0.8578) after three years. The satisfaction with the therapy was 2.9 ± 0.2 after one year, 2.6 ± 0.3 after two

Multi-year high-frequency hydrothermal monitoring of selected high-threat Cascade Range volcanoes

Science.gov (United States)

Crankshaw, I. M.; Archfield, S. A.; Newman, A. C.; Bergfeld, D.; Clor, L. E.; Spicer, K. R.; Kelly, P. J.; Evans, W. C.; Ingebritsen, S. E.

2018-05-01

From 2009 to 2015 the U.S. Geological Survey (USGS) systematically monitored hydrothermal behavior at selected Cascade Range volcanoes in order to define baseline hydrothermal and geochemical conditions. Gas and water data were collected regularly at 25 sites on 10 of the highest-risk volcanoes in the Cascade Range. These sites include near-summit fumarole groups and springs/streams that show clear evidence of magmatic influence (high 3He/4He ratios and/or large fluxes of magmatic CO2 or heat). Site records consist mainly of hourly temperature and hydrothermal-flux data. Having established baseline conditions during a multiyear quiescent period, the USGS reduced monitoring frequency from 2015 to present. The archived monitoring data are housed at (doi:10.5066/F72N5088). These data (1) are suitable for retrospective comparison with other continuous geophysical monitoring data and (2) will provide context during future episodes of volcanic unrest, such that unrest-related variations at these thoroughly characterized sites will be more clearly recognizable. Relatively high-frequency year-round data are essential to achieve these objectives, because many of the time series reveal significant diurnal, seasonal, and inter-annual variability that would tend to mask unrest signals in the absence of baseline data. Here we characterize normal variability for each site, suggest strategies to detect future volcanic unrest, and explore deviations from background associated with recent unrest.

39 CFR 4.4 - Deputy Postmaster General.

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2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Deputy Postmaster General. 4.4 Section 4.4 Postal... described at 39 U.S.C. 202(d), 203. The Deputy Postmaster General shall act as Postmaster General during the.... The Governors set the compensation and benefits of the Deputy Postmaster General, subject to 39 U.S.C...

32 CFR 33.44 - Termination for convenience.

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2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Termination for convenience. 33.44 Section 33.44 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT... convenience. Except as provided in § 33.43 awards may be terminated in whole or in part only as follows: (a...

CD44 staining of cancer stem-like cells is influenced by down-regulation of CD44 variant isoforms and up-regulation of the standard CD44 isoform in the population of cells that have undergone epithelial-to-mesenchymal transition.

Directory of Open Access Journals (Sweden)

Adrian Biddle

Full Text Available CD44 is commonly used as a cell surface marker of cancer stem-like cells in epithelial tumours, and we have previously demonstrated the existence of two different CD44(high cancer stem-like cell populations in squamous cell carcinoma, one having undergone epithelial-to-mesenchymal transition and the other maintaining an epithelial phenotype. Alternative splicing of CD44 variant exons generates a great many isoforms, and it is not known which isoforms are expressed on the surface of the two different cancer stem-like cell phenotypes. Here, we demonstrate that cancer stem-like cells with an epithelial phenotype predominantly express isoforms containing the variant exons, whereas the cancer stem-like cells that have undergone an epithelial-to-mesenchymal transition down-regulate these variant isoforms and up-regulate expression of the standard CD44 isoform that contains no variant exons. In addition, we find that enzymatic treatments used to dissociate cells from tissue culture or fresh tumour specimens cause destruction of variant CD44 isoforms at the cell surface whereas expression of the standard CD44 isoform is preserved. This results in enrichment within the CD44(high population of cancer stem-like cells that have undergone an epithelial-to-mesenchymal transition and depletion from the CD44(high population of cancer stem-like cells that maintain an epithelial phenotype, and therefore greatly effects the characteristics of any cancer stem-like cell population isolated based on expression of CD44. As well as effecting the CD44(high population, enzymatic treatment also reduces the percentage of the total epithelial cancer cell population staining CD44-positive, with potential implications for studies that aim to use CD44-positive staining as a prognostic indicator. Analyses of the properties of cancer stem-like cells are largely dependent on the ability to accurately identify and assay these populations. It is therefore critical that

29 CFR 783.44 - Board and lodging as wages.

Science.gov (United States)

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false Board and lodging as wages. 783.44 Section 783.44 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR STATEMENTS OF GENERAL... TO EMPLOYEES EMPLOYED AS SEAMEN Computation of Wages and Hours § 783.44 Board and lodging as wages...

Lemanskiite, NaCaCu5(AsO4)4Cl . 5H2O, a new mineral species from the Abundancia mine, Chile

Czech Academy of Sciences Publication Activity Database

Ondruš, P.; Veselovský, F.; Skála, Roman; Sejkora, J.; Pažout, R.; Frýda, J.; Gabasova, A.; Vajdak, J.

2006-01-01

Roč. 44, č. 2 (2006), s. 523-531 ISSN 0008-4476 Institutional research plan: CEZ:AV0Z30130516 Keywords : lemanskiite * new mineral * Abundancia mine Subject RIV: DB - Geology ; Mineralogy Impact factor: 0.972, year: 2006 http://www.canmin.org/cgi/content/abstract/44/2/523?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=44&firstpage=523&resourcetype=HWCIT

Final Technical Report 5/1/86 - 1/31/95

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-01-31

This document summarizes progress made on this project during the third year (February 1, 1994--January 31, 1995) of the current three-year grant period and outlines proposed renewal period activities of the theoretical high energy physics group at the University of Arizona.

Chondroitin sulfate addition to CD44H negatively regulates hyaluronan binding

International Nuclear Information System (INIS)

Ruffell, Brian; Johnson, Pauline

2005-01-01

CD44 is a widely expressed cell adhesion molecule that binds hyaluronan, an extracellular matrix glycosaminoglycan, in a tightly regulated manner. This regulated interaction has been implicated in inflammation and tumor metastasis. CD44 exists in the standard form, CD44H, or as higher molecular mass isoforms due to alternative splicing. Here, we identify serine 180 in human CD44H as the site of chondroitin sulfate addition and show that lack of chondroitin sulfate addition at this site enhances hyaluronan binding by CD44. A CD44H-immunoglobulin fusion protein expressed in HEK293 cells, and CD44H expressed in murine L fibroblast cells were modified by chondroitin sulfate, as determined by reduced sulfate incorporation after chondroitinase ABC treatment. Mutation of serine 180 or glycine 181 in CD44H reduced chondroitin sulfate addition and increased hyaluronan binding, indicating that serine 180 is the site for chondroitin sulfate addition in CD44H and that this negatively regulates hyaluronan binding

Test-based age-of-acquisition norms for 44 thousand English word meanings.

Science.gov (United States)

Brysbaert, Marc; Biemiller, Andrew

2017-08-01

Age of acquisition (AoA) is an important variable in word recognition research. Up to now, nearly all psychology researchers examining the AoA effect have used ratings obtained from adult participants. An alternative basis for determining AoA is directly testing children's knowledge of word meanings at various ages. In educational research, scholars and teachers have tried to establish the grade at which particular words should be taught by examining the ages at which children know various word meanings. Such a list is available from Dale and O'Rourke's (1981) Living Word Vocabulary for nearly 44 thousand meanings coming from over 31 thousand unique word forms and multiword expressions. The present article relates these test-based AoA estimates to lexical decision times as well as to AoA adult ratings, and reports strong correlations between all of the measures. Therefore, test-based estimates of AoA can be used as an alternative measure.

CD44 is involved in mineralization of dental pulp cells.

Science.gov (United States)

Chen, Kuan-Liang; Huang, Yu-Yuan; Lung, Jrhau; Yeh, Ying-Yi; Yuan, Kuo

2013-03-01

CD44 is a transmembrane glycoprotein with various biological functions. Histologic studies have shown that CD44 is strongly expressed in odontoblasts at the appositional stage of tooth development. We investigated whether CD44 is involved in the mineralization of dental pulp cells. Ten human third molars with incomplete root formation were collected and processed for immunohistochemistry of CD44. Dental pulp cells isolated from another 5 human third molars were assayed for their viability, alkaline phosphatase activity, and alizarin red staining in vitro after silencing stably their expression of CD44 by using the short hairpin RNA technique. The CD44 knockdown cells were cultured on a collagen sponge and transplanted subcutaneously into the dorsal surfaces of immunocompromised mice. After 6 weeks, the subcutaneous tissues were processed for alizarin red staining and immunohistochemistry of human specific antigen. The dental pulp cells transduced with control short hairpin RNA were used as the control in all assays. CD44 is expressed in odontogenic cells with active mineral deposition during tooth development. Odontoblasts in the root ends of immature teeth express a stronger CD44 signal compared with those in the crown portion. When CD44 expression was stably suppressed in dental pulp cells, their mineralization activities were substantially decreased in both in vitro and in vivo assays. CD44 may play a crucial role in the initial mineralization of tooth-associated structures. However, further studies are required to clarify the underlying mechanisms. Copyright © 2013 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

Bibliography on Cold Regions Science and Technology. Volume 44, Part 2

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1990-01-01

eng1 44-2171 le08*3-10488 (IQk))it. i - gj 44-390" ly) Bomi Countly. Xizang (Tibet) 11989. p,148-160. chi) Lyons. weB . Niseilek. 3L. 44-2409 Diiminion... histoirical and technical dleveliopmnt Tesnsfssrmiiins andI dssisi-oi si late-fall applied sitrogen Schaytema. G.5. 11999, p. 77 -85. enpl 44-44 during...Usnn meling ice to teach radiomectric dating. Wise, Evaluating pie-winter soil preparation for reclamation 44-100 DU .. i199. p.38- 40 ,69, cng1

Gambaran Profil Lipid pada Pasien Infark Miokard Akut di RSUP M. Djamil Padang Periode 1 Januari 2011 - 31 Desember 2012

Directory of Open Access Journals (Sweden)

Lamuna Fathila

2015-05-01

Full Text Available AbstrakInfark Miokard Akut (IMA merupakan nekrosis otot jantung akibat terganggunya kebutuhan dan suplai oksigen ke jantung secara mendadak. Faktor risikonya adalah perubahan profil lipid yaitu Kolesterol total, Kolesterol LDL. Kolesterol HDL, dan trigliserida yang dikaitkan dengan pembentukan plak aterosklerosis. Manfaat penelitian ini untuk mengetahui gambaran profil lipid pada pasien IMA. Tujuan penelitian ini untuk mengetahui gambaran profil lipid pada pasien IMA di RSUP M. Djamil Padang periode 1 Januari 2011-31 Desember 2012. Penelitian dilakukan dengan metode deskriptif dengan desain cross sectional study di bagian Rekam Medik RSUP M. Djamil Padang. Hasil penelitian menunjukkan umur terbanyak pasien IMA 45-59 tahun, Jenis kelamin terbanyak pasien IMA adalah laki-laki, perbandingannya adalah 2,7 : 1, Pasien IMA yang memiliki kadar kolesterol total tinggi 79 orang (38,92% dan normal 124 orang (61,08%, Pasien IMA yang memiliki kadar kolesterol LDL tinggi 76 orang (37,44% dan normal 127 orang (62,56%, Pasien IMA yang memiliki kadar kolesterol HDL rendah 145 orang (71,43% dan normal 58 orang (28,57%, dan Pasien IMA yang memiliki kadar trigliserida tinggi 44 orang (21,67% dan normal 159 orang (78,33%.Kata kunci: infark miokard akut, kolesterol total, kolesterol LDL, Kolesterol HDL, trigliserida AbstractAcute Myocardial Infarction (AMI is a muscle necrosis of the heart through disruption of demand and supply of oxygen to the heart suddenly. Risk factors of AMI is a change of lipid profile (Total Cholesterol, LDL Cholesterol, HDL Cholesterol, and Triglycerides associated with the formation of atherosclerotic plaque. The benefit of this research is to reveal the lipid profile in patients with AMI. The objective of this study was to determine the description of lipid profile in patients with AMI at RSUP M. Djamil Padang period January 1st, 2011-December 31th, 2012. The study was conducted with descriptive methods to the design of cross sectional

Parotid gland tumours: a six years experience

International Nuclear Information System (INIS)

Malik, K.A.

2006-01-01

To find out the different types of Parotid tumours in out setup and their prevalence in different age groups. All patients admitted with Parotid swellings, irrespective of age and sex. The detailed data of the patients was collected and analyzed. A total of 27 patients, 15 males and 12 females, with ages ranging from 15 to 65 years were included in the study. Most of the patients were in the 31-50 years of age group. Pleomorphic adenoma was the commonest benign tumour with an incidence of 66.6%, while Mucoepidermoid Carcinoma with an incidence of 11.11% was the most common malignant tumour. Parotid gland is the principal site of salivary gland tumours. Males are affected more and Pleomorphic adenoma is the most common benign and Mucoepidermoid carcinoma the most common malignant tumour. (author)

26 CFR 1.221-1 - Deduction for interest paid on qualified education loans after December 31, 2001.

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2010-04-01

... Individuals § 1.221-1 Deduction for interest paid on qualified education loans after December 31, 2001. (a) In... interest paid by the taxpayer during the taxable year on a qualified education loan. See paragraph (b)(4... paid on qualified education loans after December 31, 2001, in taxable years ending after December 31...

[Retrospective analysis of 44 childhood drowning accidents].

Science.gov (United States)

Brüning, Caroline; Siekmeyer, Werner; Siekmeyer, Manuela; Merkenschlager, Andreas; Kiess, Wieland

2010-07-01

Worldwide, drowning is the second leading cause of unintentional death and the leading cause of cardiovascular failure for children [1-3]. The number of near-drownings, where the incident is survived for at least 24 hours, is assumed to be four times as high [5]. In the years 1994 until 2008 there were 44 cases of drowning treated at the children's department of the University of Leipzig. This number shows that even in a medical centre drowning incidents are only occasional incidents. Therefore it is important to know the sequelae and handlings to be able to react in case of an emergency. A total of 44 children suffering a drowning accident within the last 48 hours who were treated during the period of 01.01.1994 through 30.06.2008 at the Children's Centre at the University of Leipzig. A retrospective analysis using a structured questionnaire was done. Social demographic data, accident progress, clinical results and progress as well as outcome of the cases were investigated. During the analysed period in the median three children were treated each year after drowning incidents. Clustering in the summer and winter months and on the weekends was recognizable. The median age was 3.33 years and the group of high risk were children aged 1-3 years, especially boys. Sixty percent of the children came from stable social backgrounds. Half of the children suffered from drowning in created swimming pools or ponds, the rest in natural waters, public pools and sources of water in the household. The median submersion lasted 2 minutes. Correlation of submersions below 1 minute with a good, and submersions above 10 minutes with a negative outcome was shown. A Glasgow Coma Scale (GCS) of 3 points (n = 15) and pupils without light reaction (n = 14) were associated with a lethal outcome or residual neurological deficits. Looking at the laboratory values, correlation between severe acidotic pH-values with a very low base excess, high blood sugar as well as high lactate values and a

Demographic effects of canine parvovirus on a free-ranging wolf population over 30 years

Science.gov (United States)

Mech, L.D.; Goyal, S.M.; Paul, W.J.; Newton, W.E.

2008-01-01

We followed the course of canine parvovinis (CPV) antibody prevalence in a subpopulation of wolves (Canis 1upus) in northeastern Minnesota from 1973, when antibodies were first detected, through 2004. Annual early pup survival was reduced by 70%, and wolf population change was related to CPV antibody prevalence. In the greater Minnesota population of 3,000 wolves, pup survival was reduced by 40-60%. This reduction limited the Minnesota wolf population rate of increase to about 4% per year compared with increases of 16-58% in other populations. Because it is young wolves that disperse, reduced pup survival may have caused reduced dispersal and reduced recolonization of new range in Minnesota. ?? Wildlife Disease Association 2008.

CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers

International Nuclear Information System (INIS)

Olsson, Eleonor; Lövgren, Kristina; Fernö, Mårten; Grabau, Dorthe; Borg, Åke; Hegardt, Cecilia; Honeth, Gabriella; Bendahl, Pär-Ola; Saal, Lao H; Gruvberger-Saal, Sofia; Ringnér, Markus; Vallon-Christersson, Johan; Jönsson, Göran; Holm, Karolina

2011-01-01

The CD44 cell adhesion molecule is aberrantly expressed in many breast tumors and has been implicated in the metastatic process as well as in the putative cancer stem cell (CSC) compartment. We aimed to investigate potential associations between alternatively spliced isoforms of CD44 and CSCs as well as to various breast cancer biomarkers and molecular subtypes. We used q-RT-PCR and exon-exon spanning assays to analyze the expression of four alternatively spliced CD44 isoforms as well as the total expression of CD44 in 187 breast tumors and 13 cell lines. ALDH1 protein expression was determined by IHC on TMA. Breast cancer cell lines showed a heterogeneous expression pattern of the CD44 isoforms, which shifted considerably when cells were grown as mammospheres. Tumors characterized as positive for the CD44 + /CD24 - phenotype by immunohistochemistry were associated to all isoforms except the CD44 standard (CD44S) isoform, which lacks all variant exons. Conversely, tumors with strong expression of the CSC marker ALDH1 had elevated expression of CD44S. A high expression of the CD44v2-v10 isoform, which retain all variant exons, was correlated to positive steroid receptor status, low proliferation and luminal A subtype. The CD44v3-v10 isoform showed similar correlations, while high expression of CD44v8-v10 was correlated to positive EGFR, negative/low HER2 status and basal-like subtype. High expression of CD44S was associated with strong HER2 staining and also a subgroup of basal-like tumors. Unsupervised hierarchical cluster analysis of CD44 isoform expression data divided tumors into four main clusters, which showed significant correlations to molecular subtypes and differences in 10-year overall survival. We demonstrate that individual CD44 isoforms can be associated to different breast cancer subtypes and clinical markers such as HER2, ER and PgR, which suggests involvement of CD44 splice variants in specific oncogenic signaling pathways. Efforts to link CD44 to

CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers

Directory of Open Access Journals (Sweden)

Vallon-Christersson Johan

2011-09-01

Full Text Available Abstract Background The CD44 cell adhesion molecule is aberrantly expressed in many breast tumors and has been implicated in the metastatic process as well as in the putative cancer stem cell (CSC compartment. We aimed to investigate potential associations between alternatively spliced isoforms of CD44 and CSCs as well as to various breast cancer biomarkers and molecular subtypes. Methods We used q-RT-PCR and exon-exon spanning assays to analyze the expression of four alternatively spliced CD44 isoforms as well as the total expression of CD44 in 187 breast tumors and 13 cell lines. ALDH1 protein expression was determined by IHC on TMA. Results Breast cancer cell lines showed a heterogeneous expression pattern of the CD44 isoforms, which shifted considerably when cells were grown as mammospheres. Tumors characterized as positive for the CD44+/CD24- phenotype by immunohistochemistry were associated to all isoforms except the CD44 standard (CD44S isoform, which lacks all variant exons. Conversely, tumors with strong expression of the CSC marker ALDH1 had elevated expression of CD44S. A high expression of the CD44v2-v10 isoform, which retain all variant exons, was correlated to positive steroid receptor status, low proliferation and luminal A subtype. The CD44v3-v10 isoform showed similar correlations, while high expression of CD44v8-v10 was correlated to positive EGFR, negative/low HER2 status and basal-like subtype. High expression of CD44S was associated with strong HER2 staining and also a subgroup of basal-like tumors. Unsupervised hierarchical cluster analysis of CD44 isoform expression data divided tumors into four main clusters, which showed significant correlations to molecular subtypes and differences in 10-year overall survival. Conclusions We demonstrate that individual CD44 isoforms can be associated to different breast cancer subtypes and clinical markers such as HER2, ER and PgR, which suggests involvement of CD44 splice variants in

Corrective Action Investigation Plan for Corrective Action Unit 490: Station 44 Burn Area, Tonopah Test Range, Nevada (with Record of Technical Change No.1)

International Nuclear Information System (INIS)

2000-01-01

This Corrective Action Investigation Plan (CAIP) contains the U.S. Department of Energy, Nevada Operations Office's approach to collect the data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 490 under the Federal Facility Agreement and Consent Order. Corrective Active Unit 490 consists of four Corrective Action Sites (CASs): 03-56-001-03BA, Fire Training Area (FTA); RG-56-001-RGBA, Station 44 Burn Area; 03-58-001-03FN, Sandia Service Yard; and 09-54-001-09L2, Gun Propellant Burn Area. These CASs are located at the Tonopah Test Range near Areas 3 and 9. Historically, the FTA was used for training exercises where tires and wood were ignited with diesel fuel. Records indicate that water and carbon dioxide were the only extinguishing agents used during these training exercises. The Station 44 Burn Area was used for fire training exercises and consisted of two wooden structures. The two burn areas (ignition of tires, wood, and wooden structures with diesel fuel and water) were limited to the building footprints (10 ft by 10 ft each). The Sandia Service Yard was used for storage (i.e., wood, tires, metal, electronic and office equipment, construction debris, and drums of oil/grease) from approximately 1979 to 1993. The Gun Propellant Burn Area was used from the 1960s to 1980s to burn excess artillery gun propellant, solid-fuel rocket motors, black powder, and deteriorated explosives; additionally, the area was used for the disposal of experimental explosive items. Based on site history, the focus of the field investigation activities will be to: (1) determine the presence of contaminants of potential concern (COPCs) at each CAS, (2) determine if any COPCs exceed field-screening levels and/or preliminary action levels, and (3) determine the nature and extent of contamination with enough certainty to support selection of corrective action alternatives for each CAS. The scope of this CAIP is to resolve the

Corrective Action Investigation Plan for Corrective Action Unit 490: Station 44 Burn Area, Tonopah Test Range, Nevada (with Record of Technical Change No.1)

Energy Technology Data Exchange (ETDEWEB)

U.S. Department of Energy, Nevada Operations Office

2000-06-09

This Corrective Action Investigation Plan (CAIP) contains the U.S. Department of Energy, Nevada Operations Office's approach to collect the data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 490 under the Federal Facility Agreement and Consent Order. Corrective Active Unit 490 consists of four Corrective Action Sites (CASs): 03-56-001-03BA, Fire Training Area (FTA); RG-56-001-RGBA, Station 44 Burn Area; 03-58-001-03FN, Sandia Service Yard; and 09-54-001-09L2, Gun Propellant Burn Area. These CASs are located at the Tonopah Test Range near Areas 3 and 9. Historically, the FTA was used for training exercises where tires and wood were ignited with diesel fuel. Records indicate that water and carbon dioxide were the only extinguishing agents used during these training exercises. The Station 44 Burn Area was used for fire training exercises and consisted of two wooden structures. The two burn areas (ignition of tires, wood, and wooden structures with diesel fuel and water) were limited to the building footprints (10 ft by 10 ft each). The Sandia Service Yard was used for storage (i.e., wood, tires, metal, electronic and office equipment, construction debris, and drums of oil/grease) from approximately 1979 to 1993. The Gun Propellant Burn Area was used from the 1960s to 1980s to burn excess artillery gun propellant, solid-fuel rocket motors, black powder, and deteriorated explosives; additionally, the area was used for the disposal of experimental explosive items. Based on site history, the focus of the field investigation activities will be to: (1) determine the presence of contaminants of potential concern (COPCs) at each CAS, (2) determine if any COPCs exceed field-screening levels and/or preliminary action levels, and (3) determine the nature and extent of contamination with enough certainty to support selection of corrective action alternatives for each CAS. The scope of this CAIP is to resolve

Comparison of Readmission Rates After Acute Myocardial Infarction in 3 Patient Age Groups (18 to 44, 45 to 64, and ≥65 Years) in the United States.

Science.gov (United States)

Khera, Rohan; Jain, Snigdha; Pandey, Ambarish; Agusala, Vijay; Kumbhani, Dharam J; Das, Sandeep R; Berry, Jarett D; de Lemos, James A; Girotra, Saket

2017-11-15

Postacute myocardial infarction (AMI) readmissions are common among Medicare beneficiaries (≥65 years) and are associated with significant resource utilization. However, patterns of AMI readmissions for younger age groups in the United States are not known. In the Nationwide Readmissions Database, a nationally representative all-payer database of inpatient hospitalizations, we identified 212,171 index AMI hospitalizations in January to November 2013, weighted to represent 478,247 hospitalizations nationally (mean age 66.9 years, 38% women, 29% low income). This included 26,516 cases in the 18 to 44 age group, 183,703 in the 45 to 64 age group, and 268,027 in the ≥65 age group. The overall 30-day readmission rate was 14.5% and varied across age groups (9.7% [18 to 44], 11.2% [45 to 64], and 17.3% [≥65]). The cumulative cost of 30-day readmissions was $1.1 billion, of which $365 million was spent on those age. In multivariable hierarchical models, the risk of readmission was higher in women and in low-income patients, but the effect varied by age (p value for age-gender and age-income interactions age groups. Further, patients in all age groups continue to have a high hospitalization burden beyond the typical 30-day readmission period, with an overall 24% post-AMI 90-day readmission rate. In conclusion, readmissions in young and middle-aged AMI survivors pose a substantial burden on patients and on U.S. health-care resources. Women and low-income patients with AMI, particularly those in younger age groups, are more frequently readmitted, and readmissions continue to burden the health-care system beyond the typical 30-day window. Future investigations would need to be targeted toward a better understanding and improvement of the rehospitalization burden for vulnerable patient groups. Copyright © 2017 Elsevier Inc. All rights reserved.

Dry Sliding Wear Charactristics of Aluminum 6061-T6, Magnesium AZ31 and Rock Dust Composite

Science.gov (United States)

Balachandar, R.; Balasundaram, R.; Rajkumar, G.

2018-02-01

In recent years, the use of aluminum composite is gaining popularity in a wide range of applications like automobiles, aerospace and constructions (both interior & exterior) panels etc., due to its high strength, low density characteristics. Various reinforcing materials are used with aluminum 6061-T6 in order to have better mechanical properties. The addition of 0.3% of magnesium AZ31 will increase the ultimate tensile strength by 25 %. The reinforcement of rock dust will decrease the density. Hence, in order to have an advantages of magnesium AZ31 and rock dust, in this work, these two constitutes are varied from 1% to 2% on the base material of Al6061-T6 in stir casting. To evaluate the wear characteristics, Pin on disc is used in these composites. The input parameters are speed, time & load. The output response is wear. To minimize the number of experiments, L9 orthogonal array is used. The test results showed that a composite of 97% of Al (6061-T6), 1% Mg (AZ31) & 2 % of rock dust produced less wear. To find the best value of operating parameter for each sample, ANN-GA is used.

Production of {sup 44}Ti in neutrino-driven aspherical supernova explosions

Energy Technology Data Exchange (ETDEWEB)

Fujimoto, Shin-ichiro [Kumamoto National College of Technology, 2659-2 Suya, Goshi 861-1102 (Japan); Ono, Masaomi; Hashimoto, Masa-aki [Department of Physics, School of Sciences, Kyushu University, Fukuoka 810-8560 (Japan); Kotake, Kei [National Astronomical Observatory Japan, 2-21-1, Osawa, Mitaka, Tokyo, 181-8588 (Japan)

2014-05-02

We examine the synthesis of {sup 44}Ti in a neutrino-driven aspherical supernova (SN), focusing on reaction rates related to {sup 44}Ti and rotation of a progenitor. We have performed 2D hydrodynamic simulations of SN of a 15M{sub ⊙} progenitor, whose angular velocity is manually set to be a cylindrical distribution and have followed explosive nucleosynthesis in the ejecta. We find that the faster rates of {sup 40}Ca(α,γ){sup 44}Ti and the slower rate of {sup 44}Ti(α,p){sup 47}V lead to more massive ejection of {sup 44}Ti and {sup 56}Ni and larger ratios <{sup 44}Ti/{sup 56}Ni>. Faster rotation also results in more massive ejection of {sup 44}Ti and {sup 56}Ni. Ratios <{sup 44}Ti/{sup 56}Ni> are however independent from rotation. Large masses of {sup 44}Ti and large ratios observed in SN 1987A and Cas A (> 1O{sup −4}M{sub ⊙} and 1-2 respectively) are not realized in all the models.

CD44 Promotes intoxication by the clostridial iota-family toxins.

Science.gov (United States)

Wigelsworth, Darran J; Ruthel, Gordon; Schnell, Leonie; Herrlich, Peter; Blonder, Josip; Veenstra, Timothy D; Carman, Robert J; Wilkins, Tracy D; Van Nhieu, Guy Tran; Pauillac, Serge; Gibert, Maryse; Sauvonnet, Nathalie; Stiles, Bradley G; Popoff, Michel R; Barth, Holger

2012-01-01

Various pathogenic clostridia produce binary protein toxins associated with enteric diseases of humans and animals. Separate binding/translocation (B) components bind to a protein receptor on the cell surface, assemble with enzymatic (A) component(s), and mediate endocytosis of the toxin complex. Ultimately there is translocation of A component(s) from acidified endosomes into the cytosol, leading to destruction of the actin cytoskeleton. Our results revealed that CD44, a multifunctional surface protein of mammalian cells, facilitates intoxication by the iota family of clostridial binary toxins. Specific antibody against CD44 inhibited cytotoxicity of the prototypical Clostridium perfringens iota toxin. Versus CD44(+) melanoma cells, those lacking CD44 bound less toxin and were dose-dependently resistant to C. perfringens iota, as well as Clostridium difficile and Clostridium spiroforme iota-like, toxins. Purified CD44 specifically interacted in vitro with iota and iota-like, but not related Clostridium botulinum C2, toxins. Furthermore, CD44 knockout mice were resistant to iota toxin lethality. Collective data reveal an important role for CD44 during intoxication by a family of clostridial binary toxins.

M31 in the Chandra Era: A High Definition Movie of a Nearby Galaxy

Science.gov (United States)

Kong, Albert; di Stefano, Rosanne

2009-09-01

M31 has been a prime targets for all X-ray missions since the first detection in 1974. With its superb spatial resolution, Chandra is unique in resolving dense source regions and detecting faint sources. Since the launch of Chandra, M31 has been regularly observed. It is perhaps the only nearby galaxy which is observed by an X-ray telescope regularly throughout operation. With 10 years of observations, the center of M31 has been observed with Chandra for nearly 1 Msec. The X-ray skies of M31 not only consist of many transients and variables, globular cluster X-ray sources in M31 are also different from our Milky Way. They are in general more luminous and one of them may even host an intermediate-mass black hole. Supersoft and quasi-soft X-ray sources in M31 are the best kept secret to unlock the nature of the progenitor of Type Ia supernova. In this talk, I will review some of the important Chandra discoveries in M31 in the past 10 years.

NewCo: Results for the period ended August 31, 2017 for the purpose of implementing tax consolidation

International Nuclear Information System (INIS)

Jugean, Anne-Sophie

2017-01-01

NewCo is the temporary name of the entity which combines all of the operations of AREVA related to the nuclear fuel cycle, whose legal name is New AREVA Holding. The NewCo capital increase reserved for the French State in the amount of 2.5 billion euro was completed on July 26, 2017. This operation resulted in AREVA SA's holding in NewCo's capital being reduced from 100% to 44.4% and, accordingly, led to the removal of the NewCo sub-group from the scope of the consolidated tax group initially created around AREVA SA. Consequently, and in order to establish the scope of the French tax consolidation group around NewCo from September 1, 2017, NewCo's Combined Shareholders' Meeting of July 27, 2017 resolved to temporarily modify the closing date of the fiscal year by setting an early closing of August 31, 2017 for the fiscal year opened January 1, 2017 (period lasting eight months), with a return to the closing date of 31 December as of the fiscal period starting September 1, 2017 (period lasting four months). In this context, NewCo has prepared the statutory and consolidated financial statements for the year opened January 1, 2017 and ended August 31, 2017. These financial statements were approved by NewCo's Board of Directors. At the closing on December 31, 2017, NewCo will draw up statutory and consolidated financial statements for the period from September 1, 2017 to December 31, 2017. Consolidated financial statements as of December 31, 2017 covering the full year 2017, i.e. a period of 12 months, will also be prepared on a voluntary basis. All the financial statements prepared by NewCo in respect of 2017 will be approved at a single General Meeting to be held in May 2018. A request to extend the deadline for the Annual Ordinary General Meeting called to approve NewCo's financial statements for the period ended August 31, 2017, will be made to the President of the Nanterre Commercial Court. NewCo's net income at August 31, 2017 was chiefly impacted, compared with

Understanding the Calcium Isotope and Trace Metal Composition of Elasmobranch Teeth: Implications for Recreating the δ44/40Ca of Seawater

Science.gov (United States)

Akhtar, A.; Higgins, J. A.

2017-12-01

Non-traditional stable isotopes in marine fossils have the potential to act as archives of paleo-seawater chemistry, biological evolution, and ancient ecosystems. In particular, bioapatite in elasmobranch enamel has been shown to be a robust proxy for environmental, geochemical and ecological reconstructions through Earth history due to its temporal range (from Devonian to present day) and resistance to diagenetic alteration. Moreover, frequent replacement rates of teeth in individuals, and high species level diversity and global distribution ensure a sample suite that encompasses a wide range of geographies and ecosystems. Here we present δ44/40Ca, δ87/86Sr and trace element (e.g. Sr/Ca, Mg/Ca) data from a suite of 300 teeth spanning the Cretaceous to present day and representing primary, secondary and tertiary piscivores. Modern teeth analyzed as part of this study have an average δ44/40Ca value of -2.07±0.48‰ (2s, n = 80) and Sr/Ca ratio of 2.30±0.24 mmol/mol (2s, n = 40), both offset from present day seawater (0 permil and 8.6 mmol/mol, respectively) due to a combination of inorganic (e.g. mineral precipitation) and biological (e.g. ionic regulation) effects. The total range in δ44/40Ca values in modern teeth is 1.19‰, the same order as that expected for variations in the δ44/40Ca value of ancient seawater. Using results from synthetic apatite synthesis experiments, mathematical modeling, and measurements of shark soft-tissue (e.g. blood and flesh), we explore sources of Ca isotope variability in shark teeth and evaluate their potential as archives of ancient seawater chemistry.

Epigenetic regulation of CD44 in Hodgkin and non-Hodgkin lymphoma

International Nuclear Information System (INIS)

Eberth, Sonja; Schneider, Björn; Rosenwald, Andreas; Hartmann, Elena M; Romani, Julia; Zaborski, Margarete; Siebert, Reiner; Drexler, Hans G; Quentmeier, Hilmar

2010-01-01

Epigenetic inactivation of tumor suppressor genes (TSG) by promoter CpG island hypermethylation is a hallmark of cancer. To assay its extent in human lymphoma, methylation of 24 TSG was analyzed in lymphoma-derived cell lines as well as in patient samples. We screened for TSG methylation using methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) in 40 lymphoma-derived cell lines representing anaplastic large cell lymphoma, Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), Hodgkin lymphoma and mantle cell lymphoma (MCL) as well as in 50 primary lymphoma samples. The methylation status of differentially methylated CD44 was verified by methylation-specific PCR and bisulfite sequencing. Gene expression of CD44 and its reactivation by DNA demethylation was determined by quantitative real-time PCR and on the protein level by flow cytometry. Induction of apoptosis by anti-CD44 antibody was analyzed by annexin-V/PI staining and flow cytometry. On average 8 ± 2.8 of 24 TSG were methylated per lymphoma cell line and 2.4 ± 2 of 24 TSG in primary lymphomas, whereas 0/24 TSG were methylated in tonsils and blood mononuclear cells from healthy donors. Notably, we identified that CD44 was hypermethylated and transcriptionally silenced in all BL and most FL and DLBCL cell lines, but was usually unmethylated and expressed in MCL cell lines. Concordant results were obtained from primary lymphoma material: CD44 was not methylated in MCL patients (0/11) whereas CD44 was frequently hypermethylated in BL patients (18/29). In cell lines with CD44 hypermethylation, expression was re-inducible at mRNA and protein levels by treatment with the DNA demethylating agent 5-Aza-2'-deoxycytidine, confirming epigenetic regulation of CD44. CD44 ligation assays with a monoclonal anti-CD44 antibody showed that CD44 can mediate apoptosis in CD44 + lymphoma cells. CD44 hypermethylated, CD44 - lymphoma cell lines were consistently

Temperature responses to the 11 year solar cycle in the mesosphere from the 31 year (1979-2010) extended Canadian Middle Atmosphere Model simulations and a comparison with the 14 year (2002-2015) TIMED/SABER observations

Science.gov (United States)

Gan, Quan; Du, Jian; Fomichev, Victor I.; Ward, William E.; Beagley, Stephen R.; Zhang, Shaodong; Yue, Jia

2017-04-01

A recent 31 year simulation (1979-2010) by extended Canadian Middle Atmosphere Model (eCMAM30) and the 14 year (2002-2015) observation by the Thermosphere Ionosphere Mesosphere and Dynamics/Sounding of the Atmosphere using Broadband Emssion Radiometry (TIMED/SABER) are utilized to investigate the temperature response to the 11 year solar cycle on the mesosphere. Overall, the zonal mean responses tend to increase with height, and the amplitudes are on the order of 1-2 K/100 solar flux unit (1 sfu = 10-22 W m-2 Hz-1) below 80 km and 2-4 K/100 sfu in the mesopause region (80-100 km) from the eCMAM30, comparatively weaker than those from the SABER except in the midlatitude lower mesosphere. A pretty good consistence takes place at around 75-80 km with a response of 1.5 K/100 sfu within 10°S/N. Also, a symmetric pattern of the responses about the equator agrees reasonably well between the two. It is noteworthy that the eCMAM30 displays an alternate structure with the upper stratospheric cooling and the lower mesospheric warming at midlatitudes of the winter hemisphere, in favor of the long-term Rayleigh lidar observation reported by the previous studies. Through diagnosing multiple dynamical parameters, it is manifested that this localized feature is induced by the anomalous residual circulation as a consequence of the wave-mean flow interaction during the solar maximum year.

The impact of reconstruction techniques on observer performance for the detection and characterization of small pulmonary nodules in chest CT of children under 13 years

NARCIS (Netherlands)

Verhagen, Martijn V.; Smets, Anne M. J. B.; van Schuppen, Joost; Deurloo, Eline E.; Schaefer-Prokop, Cornelia

2018-01-01

To compare three different reconstruction techniques of CT data for the detection of pulmonary nodules in children under 13 years. Secondly to assess the prevalence of perifissural nodular opacities. The study consisted of chest CTs of 31 children (median age 6.9 years, range 2.1-12.7), of whom 17

Long-range epigenetic silencing of chromosome 5q31 protocadherins is involved in early and late stages of colorectal tumorigenesis through modulation of oncogenic pathways

DEFF Research Database (Denmark)

Dallosso, A R; Øster, Bodil; Greenhough, A

2012-01-01

Loss of tumour suppressor gene function can occur as a result of epigenetic silencing of large chromosomal regions, referred to as long-range epigenetic silencing (LRES), and genome-wide analyses have revealed that LRES is present in many cancer types. Here we utilize Illumina Beadchip methylation...... array analysis to identify LRES across 800 kb of chromosome 5q31 in colorectal adenomas and carcinomas (n=34) relative to normal colonic epithelial DNA (n=6). This region encompasses 53 individual protocadherin (PCDH) genes divided among three gene clusters. Hypermethylation within these gene clusters......–polymerase chain reaction showed that PCDHGC3 is the highest expressed PCDH in normal colonic epithelium, and that there was a strong reciprocal relationship between PCDHGC3 methylation and expression in carcinomas (R=−0.84). PCDH LRES patterns are reflected in colorectal tumour cell lines; adenoma cell lines...

Evaluation of Soil Loss and Erosion Control Measures on Ranges and Range Structures at Installations in Temperate Climates

Science.gov (United States)

2006-06-01

Soil Loss Equation ( USLE ) and the Revised Universal Soil Loss Equation (RUSLE) continue to be widely accepted methods for estimating sediment loss...range areas. Therefore, a generalized design methodology using the Universal Soil Loss Equation ( USLE ) is presented to accommodate the variations...constructed use the slope most suitable to the area topography (3:1 or 4:1). Step 4: Using the Universal Soil Loss equation, USLE , find the values of A

Levels of 31P from [alpha]-particle capture in 27Al

NARCIS (Netherlands)

Voigt, M.J.A. de; Regenboog, D.A.; Grootenhuis, J.; Leun, C. van der

1971-01-01

Resonance energies, strengths and decay schemes have been determined for seventeen 27Al(α, γ)31P resonances in the range Eα = 2.3–3.3 MeV. New levels of 31P are reported at Ex = 6503±3, 6792±3, 7117.7±1.0, 7441.4±1.0 and 8345.5±1.5 keV. The reaction Q-value is found as 9665.1 ±1.3 keV. Doppler-shift

The corticotropin-releasing factor-like diuretic hormone 44 (DH44) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster

DEFF Research Database (Denmark)

Cannell, Elizabeth; Dornan, Anthony J.; Halberg, Kenneth Agerlin

2016-01-01

Malpighian tubules are critical organs for epithelial fluid transport and stress tolerance in insects, and are under neuroendocrine control by multiple neuropeptides secreted by identified neurons. Here, we demonstrate roles for CRF-like diuretic hormone 44 (DH44) and Drosophila melanogaster kinin...

Alternatively spliced CD44 isoforms containing exon v10 promote cellular adhesion through the recognition of chondroitin sulfate-modified CD44

NARCIS (Netherlands)

Chiu, R K; Droll, A; Dougherty, S T; Carpenito, C; Cooper, D L; Dougherty, G J

1999-01-01

Correlations have been noted between the expression of certain alternatively spliced CD44 isoforms and the metastatic propensity of various histologically distinct tumor cell types. The precise mechanism by which particular CD44 isoforms contribute to the metastatic process is, however, unclear. In

27 CFR 44.145 - Special.

Science.gov (United States)

2010-04-01

... PAYMENT OF TAX, OR WITH DRAWBACK OF TAX Operations by Export Warehouse Proprietors Inventories § 44.145 Special. A special inventory shall be made by the export warehouse proprietor whenever required by any...

Molecular mechanism for the action of the anti-CD44 monoclonal antibody MEM-85

Czech Academy of Sciences Publication Activity Database

Škerlová, Jana; Král, V.; Kachala, M.; Fábry, M.; Bumba, L.; Svergun, D. I.; Tošner, Z.; Veverka, Václav; Řezáčová, Pavlína

2015-01-01

Roč. 191, č. 2 (2015), s. 214-223 ISSN 1047-8477 R&D Projects: GA MŠk(CZ) LK11205; GA MŠk(CZ) LO1304 Institutional support: RVO:61388963 Keywords : CD44 * epitope mapping * monoclonal antibody * MEM-85 * NMR * SAXS Subject RIV: CE - Biochemistry Impact factor: 2.570, year: 2015

LERF Basin 44 Process Test Plan

International Nuclear Information System (INIS)

LUECK, K.J.

1999-01-01

This document presents a plan to process a portion of the Liquid Effluent Retention Facility (LERF) Basin 44 wastewater through the 200 Area Effluent Treatment Facility (ETF). The objective of this process test is to determine the most effective/efficient method to treat the wastewater currently stored in LERF Basin 44. The process test will determine the operational parameters necessary to comply with facility effluent discharge permit limits (Ecology 1995) and the Environmental Restoration Disposal Facility (ERDF) acceptance criteria (BHI-00139), while achieving ALARA goals and maintaining the integrity of facility equipment. A major focus of the test plan centers on control of contamination due to leaks and/or facility maintenance. As a pre-startup item, all known leaks will be fixed before the start of the test. During the course of the test, a variety of contamination control measures will be evaluated for implementation during the treatment of the remaining Basin 44 inventory. Of special interest will be techniques and tools used to prevent contamination spread during sampling and when opening contaminated facility equipment/piping. At the conclusion of the test, a post ALARA review will be performed to identify lessons learned from the test run which can be applied to the treatment of the remaining Basin 44 inventory. The volume of wastewater to be treated during this test run is 500,000 gallons. This volume limit is necessary to maintain the ETF radiological inventory limits per the approved authorization basis. The duration of the process test is approximately 30 days

Identification and characterization of RBM44 as a novel intercellular bridge protein.

Directory of Open Access Journals (Sweden)

Tokuko Iwamori

2011-02-01

Full Text Available Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells. We previously reported the identification of TEX14 as the first essential intercellular bridge protein, the demonstration that intercellular bridges are required for male fertility, and the finding that intercellular bridges utilize components of the cytokinesis machinery to form. Herein, we report the identification of RNA binding motif protein 44 (RBM44 as a novel germ cell intercellular bridge protein. RBM44 was identified by proteomic analysis after intercellular bridge enrichment using TEX14 as a marker protein. RBM44 is highly conserved between mouse and human and contains an RNA recognition motif of unknown function. RBM44 mRNA is enriched in testis, and immunofluorescence confirms that RBM44 is an intercellular bridge component. However, RBM44 only partially localizes to TEX14-positive intercellular bridges. RBM44 is expressed most highly in pachytene and secondary spermatocytes, but disappears abruptly in spermatids. We discovered that RBM44 interacts with itself and TEX14 using yeast two-hybrid, mammalian two-hybrid, and immunoprecipitation. To define the in vivo function of RBM44, we generated a targeted deletion of Rbm44 in mice. Rbm44 null male mice produce somewhat increased sperm, and show enhanced fertility of unknown etiology. Thus, although RBM44 localizes to intercellular bridges during meiosis, RBM44 is not required for fertility in contrast to TEX14.

7 CFR 1001.44 - Classification of producer milk.

Science.gov (United States)

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Classification of producer milk. 1001.44 Section 1001... SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE NORTHEAST MARKETING AREA Order Regulating Handling Classification of Milk § 1001.44 Classification of producer milk. See...

7 CFR 1033.44 - Classification of producer milk.

Science.gov (United States)

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Classification of producer milk. 1033.44 Section 1033... SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE MIDEAST MARKETING AREA Order Regulating Handling Classification of Milk § 1033.44 Classification of producer milk. See...

7 CFR 1007.44 - Classification of producer milk.

Science.gov (United States)

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Classification of producer milk. 1007.44 Section 1007... SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE SOUTHEAST MARKETING AREA Order Regulating Handling Classification of Milk § 1007.44 Classification of producer milk. See...

7 CFR 1126.44 - Classification of producer milk.

Science.gov (United States)

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Classification of producer milk. 1126.44 Section 1126... SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE SOUTHWEST MARKETING AREA Order Regulating Handling Classification of Milk § 1126.44 Classification of producer milk. See...

7 CFR 1030.44 - Classification of producer milk.

Science.gov (United States)

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Classification of producer milk. 1030.44 Section 1030... SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE UPPER MIDWEST MARKETING AREA Order Regulating Handling Classification of Milk § 1030.44 Classification of producer milk...

7 CFR 1131.44 - Classification of producer milk.

Science.gov (United States)

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Classification of producer milk. 1131.44 Section 1131... SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE ARIZONA MARKETING AREA Order Regulating Handling Classification of Milk § 1131.44 Classification of producer milk. See...

7 CFR 1124.44 - Classification of producer milk.

Science.gov (United States)

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Classification of producer milk. 1124.44 Section 1124... SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE PACIFIC NORTHWEST MARKETING AREA Order Regulating Handling Classification of Milk § 1124.44 Classification of producer milk...

7 CFR 1006.44 - Classification of producer milk.

Science.gov (United States)

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Classification of producer milk. 1006.44 Section 1006... SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE FLORIDA MARKETING AREA Order Regulating Handling Classification of Milk § 1006.44 Classification of producer milk. See...

7 CFR 1032.44 - Classification of producer milk.

Science.gov (United States)

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Classification of producer milk. 1032.44 Section 1032... SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE CENTRAL MARKETING AREA Order Regulating Handling Classification of Milk § 1032.44 Classification of producer milk. See...

7 CFR 1005.44 - Classification of producer milk.

Science.gov (United States)

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Classification of producer milk. 1005.44 Section 1005... SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE APPALACHIAN MARKETING AREA Order Regulating Handling Classification of Milk § 1005.44 Classification of producer milk...

Business report on the 14th financial year from January 1 to December 31, 1977

International Nuclear Information System (INIS)

1978-03-01

Within this annual report, the director's report deals with technical and economic aspects and with personnel problems. The annual settlement statement is explained, and economic balance is given for December 31, 1977, and the profit-loss calculation is given. (UA) [de

ISIS annual report for the financial year 1 April 1991 to 31 March 1992. V. 1

International Nuclear Information System (INIS)

Wilson, C.

1992-07-01

Volume 1 of the 1992 Annual Report of ISIS, the neutron scattering facility based at the Rutherford Appleton Laboratory contains details of the work of the Facility over the past year. In addition to reports on the status of the accelerator and instruments, instrument developments, support facilities, publications etc, Volume 1 contains summaries of the science performed, often with reference to reports contained in the current volume. In addition, there are more extended articles highlighting a range of recently performed experiments. (author)

31-Year-Old Female Shows Marked Improvement in Depression, Agitation, and Panic Attacks after Genetic Testing Was Used to Inform Treatment

Directory of Open Access Journals (Sweden)

Scott Lawrence

2014-01-01

Full Text Available This case describes a 31-year-old female Caucasian patient with complaints of ongoing depression, agitation, and severe panic attacks. The patient was untreated until a recent unsuccessful trial of citalopram followed by venlafaxine which produced a partial response. Genetic testing was performed to assist in treatment decisions and revealed the patient to be heterozygous for polymorphisms in 5HT2C, ANK3, and MTHFR and homozygous for a polymorphism in SLC6A4 and the low activity (Met/Met COMT allele. In response to genetic results and clinical presentation, venlafaxine was maintained and lamotrigine was added leading to remission of agitation and depression.

Post-Closure Inspection Report for the Tonopah Test Range, Nevada, For Calendar Year 2008

International Nuclear Information System (INIS)

2009-01-01

This report provides the results of the annual post-closure inspections conducted at the closed Corrective Action Unit (CAU) sites located on the Tonopah Test Range (TTR), Nevada. This report covers calendar year 2008 and includes inspection and repair activities completed at the following ten CAUs: CAU 400: Bomblet Pit and Five Points Landfill (TTR) CAU 404: Roller Coaster Lagoons and Trench (TTR) CAU 407: Roller Coaster RadSafe Area (TTR) CAU 423: Area 3 Underground Discharge Point, Building 0360 (TTR) CAU 424: Area 3 Landfill Complexes (TTR) CAU 426: Cactus Spring Waste Trenches (TTR) CAU 427: Area 3 Septic Waste Systems 2, 6 (TTR) CAU 453: Area 9 UXO Landfill (TTR) CAU 484: Surface Debris, Waste Sites, and Burn Area (TTR) CAU 487: Thunderwell Site (TTR)

Post-Closure Inspection Report for the Tonopah Test Range, Nevada, For Calendar Year 2008

Energy Technology Data Exchange (ETDEWEB)

NSTec Environmental Restoration

2009-03-19

This report provides the results of the annual post-closure inspections conducted at the closed Corrective Action Unit (CAU) sites located on the Tonopah Test Range (TTR), Nevada. This report covers calendar year 2008 and includes inspection and repair activities completed at the following ten CAUs: CAU 400: Bomblet Pit and Five Points Landfill (TTR) CAU 404: Roller Coaster Lagoons and Trench (TTR) CAU 407: Roller Coaster RadSafe Area (TTR) CAU 423: Area 3 Underground Discharge Point, Building 0360 (TTR) CAU 424: Area 3 Landfill Complexes (TTR) CAU 426: Cactus Spring Waste Trenches (TTR) CAU 427: Area 3 Septic Waste Systems 2, 6 (TTR) CAU 453: Area 9 UXO Landfill (TTR) CAU 484: Surface Debris, Waste Sites, and Burn Area (TTR) CAU 487: Thunderwell Site (TTR)

Withdrawal of corticosteroids in inflammatory bowel disease patients after dependency periods ranging from 2 to 45 years: a proposed method.

LENUS (Irish Health Repository)

Murphy, S J

2012-02-01

BACKGROUND: Even in the biologic era, corticosteroid dependency in IBD patients is common and causes a lot of morbidity, but methods of withdrawal are not well described. AIM: To assess the effectiveness of a corticosteroid withdrawal method. METHODS: Twelve patients (10 men, 2 women; 6 ulcerative colitis, 6 Crohn\\'s disease), median age 53.5 years (range 29-75) were included. IBD patients with quiescent disease refractory to conventional weaning were transitioned to oral dexamethasone, educated about symptoms of the corticosteroid withdrawal syndrome (CWS) and weaned under the supervision of an endocrinologist. When patients failed to wean despite a slow weaning pace and their IBD remaining quiescent, low dose synthetic ACTH stimulation testing was performed to assess for adrenal insufficiency. Multivariate analysis was performed to assess predictors of a slow wean. RESULTS: Median durations for disease and corticosteroid dependency were 21 (range 3-45) and 14 (range 2-45) years respectively. Ten patients (83%) were successfully weaned after a median follow-up from final wean of 38 months (range 5-73). Disease flares occurred in two patients, CWS in five and ACTH testing was performed in 10. Multivariate analysis showed that longer duration of corticosteroid use appeared to be associated with a slower wean (P = 0.056). CONCLUSIONS: Corticosteroid withdrawal using this protocol had a high success rate and durable effect and was effective in patients with long-standing (up to 45 years) dependency. As symptoms of CWS mimic symptoms of IBD disease flares, gastroenterologists may have difficulty distinguishing them, which may be a contributory factor to the frequency of corticosteroid dependency in IBD patients.

Accounts for the year ended 31 March 1991

International Nuclear Information System (INIS)

1991-01-01

Group accounts for the group which comprised the AEA and its 100% owned subsidiary AEA Insurance Limited are presented. AEA Technology is the trading name of the United Kingdom Atomic Energy Authority. The group's principal activity is selling a wide range of advanced technical services and products. These services are delivered through two groups -one offering traditional support to nuclear utilities, the other innovative advanced technology solutions to assist manufacturing industry. Balance sheets are given and explained. The financial highlights show an operating profit of Pound 17.7 million with an overall loss, due to restructuring and exceptional expenditure, of Pound 40 million. (author)

Exertional muscle pain in familial Mediterranean fever patients evaluated by MRI and 31P magnetic resonance spectroscopy

International Nuclear Information System (INIS)

Kushnir, T.; Eshed, I.; Heled, Y.; Livneh, A.; Langevitz, P.; Ben Zvi, I.; Konen, E.; Lidar, M.

2013-01-01

Aim: To evaluate the effect of physical activity on the structural, morphological, and metabolic characteristics of the gastrocnemius muscle in familial Mediterranean fever (FMF) patients, utilizing quantitative 31 P magnetic resonance spectroscopy (MRS), in order to elucidate the mechanism of their exertional leg pain. Materials and methods: Eleven FMF patients suffering from exertional leg pain (eight male, three female; mean age 33 years) and six healthy individuals (three male, three female; mean age 39 years) constituted the control group. All of the participants underwent magnetic resonance imaging (MRI) and non-selective 31 P MRS (3 T) of the leg muscles before and after graded exercise on a treadmill. Phosphocreatine (PCr):inorganic phosphate (Pi), PCr:adenosine triphosphate (ATP) ratios and the intracellular pH of the leg muscles were measured using 31 P MRS. Results: For both groups, normal muscle mass with no signal alterations was observed on the MRI images after exercise. The normal range of pre- and post- exercise MRS muscle parameters was observed in both groups. However, the intracellular pH post-exercise, was significantly higher (less acidic) in the FMF group compared to the control group [pH (FMF) = 7.03 ± 0.02; pH (control) 7.00 ± 0.02; p < 0.0006]. Conclusions: The finding of a less prominent, post-exercise acidification of the gastrocnemius muscle in this FMF patient group suggests a forme fruste of glycogenosis. This preliminary observation should be further investigated in a future, larger-scale study

Tomosynthesis Impact on Breast Cancer Screening in Patients Younger Than 50 Years Old.

Science.gov (United States)

Rose, Stephen L; Shisler, Julie L

2018-04-09

The question of benefits versus harms of breast cancer screening for women younger than 50 years old has been the subject of debate. We investigate if the addition of tomosynthesis to mammography improves screening performance outcomes for women in this age group. Screening performance for 59,921 patients (41,542 digital mammography and 18,379 tomosynthesis) younger than 50 years old was collected from a community-based screening network from January 1, 2015, to December 31, 2015. Patients were offered tomosynthesis if it was available. Parameters including recall, biopsy, and cancer detection rates were compared. Mixed effects regression analysis was used to estimate rates with screening modality, age, and density as fixed effects and screening site as a random effect. Rates for patients with dense breast tissue were also evaluated. Model adjusted rates per 1000 screenings with digital mammography were compared with digital mammography plus tomosynthesis, respectively: recall rate decreased from 117 to 108 (difference, -8.3; p = 0.003); biopsy rate increased from 13.5 to 16.6 (difference, 3.1; p = 0.003); and cancer detection rate increased from 1.9 to 2.6 (difference, 0.8; p = 0.060). Model adjusted rates for patients with dense breast tissue were: recall rate decreased from 135 to 132 (difference, -3.2; p = 0.44); biopsy rate increased from 16.0 to 20.5 (difference, 4.5; p = 0.004); and cancer detection rate increased from 2.1 to 3.5 (difference, 1.3; p = 0.03). Tomosynthesis in a community setting resulted in decreased recall rates for patients younger than 50 years old. For the subgroup of women with dense breast tissue, cancer detection rates also increased.

Study of deformation texture in an AZ31 magnesium alloy rolled at wide range of rolling speed and reductions

International Nuclear Information System (INIS)

Sanjari, M; Su, J; Kabir, A S; Yue, S; Tamimi, S; Hara, K; Utsunomiya, H; Petrov, R; Kestens, L

2015-01-01

The plasticity of Mg is restricted at low temperatures because: (a) only a small number of deformation mechanisms can be activated, and (b) a preferred crystallographic orientation (texture) develops in wrought alloys, especially in flat-rolled sheets. This causes problems in thin sheet processing as well as component manufacturing from the sheet. In this study, different rolling speeds from 15 to 1000 m/min were employed to warm-roll AZ31B magnesium alloy to different reductions. The results show that AZ31B sheets rolled at 15 m/min and 100 °C has fractured for reductions of more than 30% per pass. However, by increasing the rolling speed to 1000 m/min the rollability was improved significantly and the material can be rolled to reductions of more than 70% per pass. The results show that with increasing strain rate at 100°C, the splitting of basal poles was observed, indicating the activation of more contraction twins and secondary twins. (paper)

21 CFR 16.44 - Communication to presiding officer and Commissioner.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Communication to presiding officer and Commissioner. 16.44 Section 16.44 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... Officer § 16.44 Communication to presiding officer and Commissioner. (a) Regulatory hearings are not...

Better Survival of Total Knee Replacement in Patients Older Than 70 Years: A Prospective Study with 8 To 12 Years Follow-Up

Directory of Open Access Journals (Sweden)

Ricardo Fernandez-Fernandez

2015-01-01

Full Text Available  Background: Modern knee designs have popularized its use in younger patients due to its better performance. There remains uncertainty whether higher demands of these patients can affect implant survivorship.    Purpose: To assess whether modern knee designs have provided similar results in patients younger than 70 years versus older patients. Methods: We included 203 consecutive patients (236 knees who underwent knee replacement for osteoarthritis with a mean follow-up of 11.4 years (range: 8.8 to 12. The mean age was 70 years (range: 31 to 85. Knee replacements were stratified into two groups: 109 were younger than 70 years and 127 were older than 70 years (70 years of age is the mandatory retirement age. Results: There were no significant pre-operative differences between groups with regards to knee alignment, alpha or beta angles, knee score or function score. Fourteen implants were radiographically loose at last follow up visit. Groups were matched in terms of demographic data. We found that patients older than 70 years had significantly better mean survivorship at 12 years. (97% vs. 88%; P=0.010. Patients under 70 years presented with a higher rate of polyethylene wear which was further associated with radiolucent lines in the femur and tibia as well as the presence of osteolysis. There was also an association between migration and presence of osteolysis. Conclusions: Patients over 70 years old undergoing cemented total knee replacement for osteoarthritis showed better implant survivorship versus patients under 70 years old.

The Manitoba Hydro-Electric Board, 42nd annual report for the year ended March 31, 1993

International Nuclear Information System (INIS)

1993-01-01

Manitoba Hydro is a provincially owned corporation that produces electricity for distribution to 380,270 customers throughout all of Manitoba except for central Winnipeg. The utility operates 12 hydraulic generating stations, 2 thermal generating stations and 12 diesel sites. In the year ending March 31, 1993, total combined generation and imports were 27.8 billion kWh, of which 26.5 billion kWh was produced from hydraulic stations. Power sales to Manitoba customers totalled 14.6 billion kWh and extraprovincial sales totalled 9 billion kWh. Gross revenues were $823 million and total expenses were $847 million, for a net loss of $24 million. An all-time record high for exports was set at $142.7 million, partly due to good water flows and energy available from the Limestone Generating Station. Cancellation of a 1,000 MW purchase by Ontario Hydro resulted in suspension of construction of the Conawapa Project and associated transmission lines. The various sections of the report present information on customer services; employee relations; environmental management; resource planning; electricity generated, purchased, and exported; system development, including construction of new power plants; research and development; and safety. Financial statements are included. 32 figs., 4 tabs

The Manitoba Hydro-Electric Board, 43nd annual report for the year ended March 31, 1994

International Nuclear Information System (INIS)

1994-01-01

Manitoba Hydro is a provincially owned corporation that produces electricity for distribution to 380,270 customers throughout all of Manitoba except for central Winnipeg. The utility operates 12 hydraulic generating stations, 2 thermal generating stations and 12 diesel sites. In the year ending March 31, 1994, total combined generation and imports were 27.6 billion kWh, of which 95.2% was produced from hydraulic stations. Power sales to Manitoba customers totalled 15 billion kWh and extraprovincial sales totalled 9.16 billion kWh. Gross revenues were $924.8 million and total expenses were $855.3 million, for a net income of $69.5 million. Total out-of-province sales reached a record high of $231.6 million, or 62.3% more than in 1992/93. That increase was mainly due to a 500-MW firm power sale to Northern States Power. The various sections of the report present information on customer services; employee relations; environmental management; resource planning; electricity generated, purchased, and exported; system development, including construction of new transmission lines and stations; research and development; and safety. Financial statements are included. 25 figs., 5 tabs

44 CFR 10.14 - Flood plains and wetlands.

Science.gov (United States)

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Flood plains and wetlands. 10... Flood plains and wetlands. For any action taken by FEMA in a flood plain or wetland, the provisions of... Executive Order 11988, Flood Plain Management, and Executive Order 11990, Protection of Wetlands (44 CFR...

The dentist workforce in Kuwait to the year 2020.

Science.gov (United States)

Al-Jarallah, K F; Moussa, M A A; Al-Duwairi, Y; Zaatar, E; Al-Khanfar, K F

2010-09-01

To project the future demand for dentists in Kuwait for the years 2007 to 2020 based on the period 1994 to 2006. The study addresses the supply of and demand for dentists in Kuwait in the light of emerging variables such as increasing population, economic growth, changes in dental care, education strategies, and changes in demographics of dentists. Population projections for the years 2007 to 2020 were derived using the average annual natural increase rate of the 1994-2006 populations. The future demand for dentists for the years 2007 to 2020 was projected using the average dentist to population ratios of the years 1994-2006. The average annual growth rate of indigenous Kuwaiti dentists during the period 1994-2006 was 5.58% compared to 31.9% for non-native expatriot dentists. There is a gap between the numbers of native and foreign dentists. In 2006, native dentists constituted 44.4% of the dental workforce in Kuwait, this is likely to affect the quality of provided dental care owing to language, religious and sociocultural barriers between foreign dentists and patients. The disparity between the total number of dentists needed and the number of native dentists is expected to decline from 54.41% in 2007 to 24.67% in 2020. The supply of native dentists is likely to remain insufficient to meet the projected demand until the year 2020. The supply of indigenous dentists should be increased through improvement in recruitment and retention of Kuwaiti national dentists and dental students.

Molecular mechanism for the action of the anti-CD44 monoclonal antibody MEM-85

Czech Academy of Sciences Publication Activity Database

Škerlová, Jana; Král, Vlastimil; Kachala, M.; Fábry, Milan; Bumba, Ladislav; Svergun, D.I.; Tosner, Z.; Veverka, V.; Řezáčová, Pavlína

2015-01-01

Roč. 191, č. 2 (2015), s. 214-223 ISSN 1047-8477 R&D Projects: GA ČR(CZ) GA15-11851S EU Projects: European Commission 264257 Institutional support: RVO:68378050 ; RVO:61388971 Keywords : CD44 * Epitope mapping * Monoclonal antibody * MEM-85 * SAXS * NMR Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.570, year: 2015

31 CFR 31.211 - Organizational conflicts of interest.

Science.gov (United States)

2010-07-01

... conflict may depend on a variety of factors, including the type of conflict, the scope of work under the... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Organizational conflicts of interest... ASSET RELIEF PROGRAM Conflicts of Interest § 31.211 Organizational conflicts of interest. (a) Retained...

Development and evaluation of a novel fast broad-range 16S ribosomal DNA PCR and sequencing assay for diagnosis of bacterial infective endocarditis: multi-year experience in a large Canadian healthcare zone and a literature review.

Science.gov (United States)

Miller, Robert J H; Chow, Barbara; Pillai, Dylan; Church, Deirdre

2016-04-12

The study aimed to explore the sensitivity and specificity of a novel fast 16S rDNA PCR and sequencing assay for the improved diagnosis of infective endocarditis (IE) in patients with suspected native or prosthetic heart valve (HV) infection over a multi-year period at our cardiovascular center. Sixty-eight patients were prospectively enrolled who underwent HV replacement for suspected or confirmed IE between February 1, 2009 and September 1, 2014. Patient demographics, medical co-morbidities, Duke's criteria, culture results, and antibiotic therapy were collected by detailed chart reviews. Dual-priming oligonucleotide primers targeted to 500 bps of the V1-V3 region of the 16S rRNA gene were used to perform fast broad-range 16S rDNA PCR and Sanger sequencing on ribosomal DNA extracted from HV tissues. The performance/diagnostic efficiency of the molecular test was evaluated against blood cultures and Gram stain and culture of HV tissue in patients' with definite IE according to Duke's criteria. Fifty patients (73.5%) had definite IE and another 8 (11.8%) had possible IE according to Duke's criteria. Cardiac surgery was delayed an average of 15.4 days from the time of the patient's last positive blood culture, and appropriate antibiotic therapy was given in the pre-operative period. While 44/50 (88%) patients had a positive blood culture, HV tissue culture was only positive in 23 (46%) of them. Molecular testing of all HV tissues had sensitivity, specificity, NPV and PPV of 92, 77.8, 77.8 and 92% compared to 44, 100, 39.1 and 100% respectively for culture for diagnosis of definite IE. For prosthetic HV tissue, 16S rDNA PCR had sensitivity of 93% and specificity of 83% compared to 35 and 100% respectively for culture. A literature review showed that the diagnostic accuracy of our novel fast broad-range 16S rDNA PCR assay was similar or better than that of previously published studies. This novel fast broad-range 16S rDNA PCR/sequencing test had superior sensitivity

Super-ranging. A new ranging strategy in European badgers.

Directory of Open Access Journals (Sweden)

Aoibheann Gaughran

Full Text Available We monitored the ranging of a wild European badger (Meles meles population over 7 years using GPS tracking collars. Badger range sizes varied seasonally and reached their maximum in June, July and August. We analysed the summer ranging behaviour, using 83 home range estimates from 48 individuals over 6974 collar-nights. We found that while most adult badgers (males and females remained within their own traditional social group boundaries, several male badgers (on average 22% regularly ranged beyond these traditional boundaries. These adult males frequently ranged throughout two (or more social group's traditional territories and had extremely large home ranges. We therefore refer to them as super-rangers. While ranging across traditional boundaries has been recorded over short periods of time for extraterritorial mating and foraging forays, or for pre-dispersal exploration, the animals in this study maintained their super-ranges from 2 to 36 months. This study represents the first time such long-term extra-territorial ranging has been described for European badgers. Holding a super-range may confer an advantage in access to breeding females, but could also affect local interaction networks. In Ireland & the UK, badgers act as a wildlife reservoir for bovine tuberculosis (TB. Super-ranging may facilitate the spread of disease by increasing both direct interactions between conspecifics, particularly across social groups, and indirect interactions with cattle in their shared environment. Understanding super-ranging behaviour may both improve our understanding of tuberculosis epidemiology and inform future control strategies.

Campbell Creek TVA 2010 First Year Performance Report July 1, 2009 August 31, 2010

Energy Technology Data Exchange (ETDEWEB)

Christian, Jeffrey E [ORNL; Gehl, Anthony C [ORNL; Boudreaux, Philip R [ORNL; New, Joshua Ryan [ORNL

2010-10-01

This research project was initiated by TVA in March 2008 and encompasses three houses that are of similar size, design and located within the same community - Campbell Creek, Farragut TN with simulated occupancy. This report covers the performance period from July 1, 2009 to August 31, 2010. It is the intent of TVA that this Valley Data will inform electric utilities future residential retrofit incentive program.

Advanced Orofacial Rhabdomyosarcoma: A Retrospective Study of 31 Cases.

Science.gov (United States)

Otmani, Naima; Khattab, Mohamed

2016-07-01

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma encountered in childhood and adolescence. Early diagnosis of pediatric cases is critical to improving outcomes, especially when socioeconomic status and geographical access to specialist services can reduce opportunities for early cancer detection and treatment. The objective of this study is to determine factors that can delay referral and treatment in specialist pediatric oncology center upon our population specificities. This retrospective study involved 31 children between 2003 and 2013. Children affected by histologically confirmed RMS occurring as a primary lesion in the orofacial area were included. The median age was 8 ± 4.22 years (range: 3 months - 15 years). The male to female ratio was 1.8:1. Most of the patients had advanced stage disease at presentation (81.7% group had 3-4 pretreatment staging) with parameningeal involvement in 80.6% of the cases. The 2-year event-free survival rate was 17.7 ± 7.8% for all the patients. Delay of admission to our unit and abandonment of treatment seem to be important factors for the dismal prognosis. Patient's location, socioeconomic status and health care coverage have had an impact on longer delays in seeking care and on follow-up. More studies are needed for implementation of a better management practices and a better supportive care upon specificities of our population.

27 CFR 44.264a - To a foreign-trade zone.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false To a foreign-trade zone. 44.264a Section 44.264a Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... Warehouses Notice of Removal of Shipment § 44.264a To a foreign-trade zone. Where cigars are withdrawn from a...

27 CFR 44.196a - To a foreign-trade zone.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false To a foreign-trade zone. 44.196a Section 44.196a Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... Shipment § 44.196a To a foreign-trade zone. Where tobacco products, and cigarette papers and tubes are...

27 CFR 44.207a - To a foreign-trade zone.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false To a foreign-trade zone. 44.207a Section 44.207a Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... of Shipment § 44.207a To a foreign-trade zone. Where tobacco products, and cigarette papers and tubes...

Determination of reference ranges for immature platelet and reticulocyte fractions and reticulocyte hemoglobin equivalent

Directory of Open Access Journals (Sweden)

Iuri Vicente Camargo Morkis

Full Text Available ABSTRACT Introduction: The immature platelet and immature reticulocyte fractions represent the ratios of platelets and reticulocytes recently released into the circulation and thus with higher RNA content. They are considered early indicators of bone marrow recovery. Objective: The aim of this study was to determine the reference ranges for the immature platelet and reticulocyte fractions of hematologically normal individuals in a university hospital. Methods: Venous blood samples collected in ethylenediaminetetraacetic acid K3 were analyzed using a Sysmex XE-5000™ analyzer. Individuals with platelet and reticulocyte counts within the reference ranges, and a blood count within the laboratory's screening criteria were included. Individuals with clinical conditions that could affect hematological results were excluded. The immature platelet fraction, high, medium and low fluorescence reticulocyte fractions and reticulocyte hemoglobin equivalent were evaluated. The reference ranges were determined according to the recommendations of the International Federation of Clinical Chemistry. Results: One hundred and thirty-two outpatients were evaluated. The mean age was 44 years (range: 13-80 years, 72 (54.5% were women treated in a university hospital. The mean platelet count was 250.8 × 109/L and the mean reticulocyte count was 0.052 × 109/L. The following reference ranges were obtained: immature reticulocyte fraction 1.6-12.1%, the high, medium and low fluorescence reticulocyte fractions were 0.0-1.7%, 1.6-11.0% and 87.9-98.4%, respectively, the reticulocyte hemoglobin equivalent was 30.0-37.6% and immature platelet fraction was 0.8-5.6%. There was a statistically significant difference (p-value = 0.006 between genders in respect to the immature platelet fraction with 0.8-4.7% for females and 0.7-6.1% for males. The immature reticulocyte fraction was directly correlated with the reticulocyte count. Conclusion: Determining the reference range is

Incidence of HACEK bacteraemia in Denmark

DEFF Research Database (Denmark)

Lützen, Lisbeth; Olesen, Bente; Voldstedlund, Marianne

2018-01-01

to an annual incidence of 0.44 per 100,000 population. The annual incidence for males and females was 0.56 and 0.31 per 100,000, respectively. The median age was 56 years (range 0-97 years) with variation among genera. One hundred and forty-three isolates were identified to the species level and six...... to the genus level: Haemophilus spp. n=55, Aggregatibacter spp. n=37, Cardiobacterium spp. n=9, Eikenella corrodens n=21, and Kingella spp. n=27. CONCLUSIONS: This is the first study of incidence of HACEK bacteraemia in a large surveillance population and may inspire further studies of the HACEK group...

Areva as of December 31, 2011

International Nuclear Information System (INIS)

Marie, Patricia; Briand, Pauline; Michaut, Maxime; Scorbiac, Marie de; Repaire, Philippine du

2012-01-01

In 2011, AREVA's consolidated revenue came to 8.872 billion euros, down slightly (-2.6%) compared with 2010 (-1.2% like for like). The decrease in revenue in nuclear operations was partially offset by significant growth in the renewable energies business. Foreign exchange and changes in the scope of consolidation had respectively a negative impact of 113 million euros and 16 million euros over the period. Revenue totaled 2.922 billion euros in the fourth quarter of 2011, stable compared with the fourth quarter of 2010 (-0.5% on a reported basis and -0.5% like for like). Foreign exchange had a negligible impact during the period. Led by nuclear operations, the group's backlog was 45.6 billion euros at December 31, 2011, up 3.1% year on year and 6.7% in relation to September 30, 2011. Order cancellations since Fukushima were limited to 464 million euros as of December 31, 2011. In accordance with the requirements of IFRS 8, AREVA's business segment information is presented for each operating Business Group (BG), which is the level of information examined by the group's governance bodies. Subsequent to the establishment of a subsidiary combining all of the group's mining operations, data for the Mining Business Group are now reported separately from those of the Front End Business Group. Data used for comparisons with 2010 were restated to reflect this new organization. The business segment information therefore corresponds to AREVA's five operating Business Groups: Mining, Front End, Reactors and Services, Back End and Renewable Energies

44 CFR 401.3 - Reports.

Science.gov (United States)

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Reports. 401.3 Section 401.3... RESTRICTIONS (T-1) § 401.3 Reports. Persons subject to this order shall submit such reports to the Assistant... Reports Act. ...

Weak transitions in 44Ca

International Nuclear Information System (INIS)

Tauhata, L.; Marques, A.

1972-01-01

Energy levels and gamma radiation transitions of Ca 44 are experimentally determined, mainly the weak transition at 564 KeV and 728 KeV. The decay scheme and the method used (coincidence with Ge-Li detector) are also presented [pt

Evaluation of phosphorus characterization in broiler ileal digesta, manure, and litter samples: (31)P-NMR vs. HPLC.

Science.gov (United States)

Leytem, A B; Kwanyuen, P; Plumstead, P W; Maguire, R O; Brake, J

2008-01-01

Using 31-phosphorus nuclear magnetic resonance spectroscopy ((31)P-NMR) to characterize phosphorus (P) in animal manures and litter has become a popular technique in the area of nutrient management. To date, there has been no published work evaluating P quantification in manure/litter samples with (31)P-NMR compared to other accepted methods such as high performance liquid chromatography (HPLC). To evaluate the use of (31)P-NMR to quantify myo-inositol hexakisphosphate (phytate) in ileal digesta, manure, and litter from broilers, we compared results obtained from both (31)P-NMR and a more traditional HPLC method. The quantification of phytate in all samples was very consistent between the two methods, with linear regressions having slopes ranging from 0.94 to 1.07 and r(2) values of 0.84 to 0.98. We compared the concentration of total monoester P determined with (31)P-NMR with the total inositol P content determined with HPLC and found a strong linear relationship between the two measurements having slopes ranging from 0.91 to 1.08 and r(2) values of 0.73 to 0.95. This suggests that (31)P-NMR is a very reliable method for quantifying P compounds in manure/litter samples.

The Romanian National Program for Liver Transplantation - 852 Procedures in 815 Patients over 17 Years (2000-2017): A Continuous Evolution to Success.

Science.gov (United States)

Popescu, Irinel; Ionescu, Mihnea; Braşoveanu, Vladislav; Hrehoreţ, Doina; Copca, Narcis; Lupaşcu, Cristian; Botea, Florin; Dorobanţu, Bogdan; Alexandrescu, Sorin; Grigorie, Mihai; Matei, Emil; Zamfir, Radu; Lungu, Vasile; Tomescu, Dana; Droc, Gabriela; Ungureanu, Daniela; Fota, Ruxandra; Manga, Graţiela; Popescu, Mihai; Popa, Laura; Gheorghe, Liana; Iacob, Speranţa; Pietrăreanu, Corina; Mihailă, Mariana; Mic, Laurenţiu; Constantinescu, Sanda; Gheorghe, Cristian; Cotruta, Bogdan; Lupescu, Ioana; Grasu, Mugur; Boroş, Mirela; Dumitru, Radu; Toma, Mihai; Paslaru, Liliana; Vlad, Laura; Constantinescu, Ileana; Dima, Ileana; Herlea, Vlad; Becheanu, Gabriel; Pecheanu, Cătălin; Sasalovici, Daniela

2017-01-01

Background: Liver transplantation (LT) has become an established treatment for end-stage liver disease, with more than 20.000 procedures yearly worldwide. The aim of this study was to analyze the results of Romanian National Program of LT. Methods: Between April 2000 and April 2017, 817 pts received 852 LTs in Romania. Male/female ratio was 487/330, while adult/pediatric ratio was 753/64, with a mean age of 46 years (median 50 yrs; range 7 months - 68 yrs). Main LT indications were HBV cirrhosis (230 pts; 28.2%), HCC (173 pts; 21.2%), and HCV cirrhosis (137 pts; 16.8%). Waiting time and indications for LT, patient and donor demographics, graft features, surgical procedures, and short and long-term outcomes were analyzed. Results: DDLT was performed in 682 pts (83.9%): whole LT in 662 pts (81%), split LT in 16 pts (2.3%), reduced LT in 2 pts (0.2%), and domino LT in 1 pts (0.1%). LDLT was performed in 135 pts (16.5%): right hemiliver in 93 pts (11.4%), left lateral section in 28 pts (3.4%), left hemiliver in 8 pts (1%), left hemiliver with segment 1 in 4 pts (0.5%), and dual graft LDLT in 2 pts (0.2%). Overall major morbidity rate was 31.4% (268 pts), while perioperative mortality was 7.9% (65 pts). Retransplantation rate was 4.3% (35 pts): 27 whole LTs, 3 reduced LTs, 3 split LTs, and 2 LDLT. Long-term overall 1-, 3-, and 5-year estimated survival rates for patients were 87.9%, 81.5%, and 79.1%, respectively. One-, 3-, and 5-year overall mortality on waiting list also decreased significantly over time from 31.4%, 54.1% and 63.5%, to 4.4%, 13.9% and 23.6%, respectively. Conclusions: The Romanian National program for liver transplantation addresses all causes of acute and chronic liver failure or liver tumors in adults and children, using all surgical techniques, with good long-term outcome. The program constantly evolved over time, leading to decreased mortality rate on the waiting list. Celsius.

Green Bank Telescope Observations of HI in the circumgalactic medium of M31

Science.gov (United States)

Denny, Lucas; Early, Laura; Berg, Michelle; Howk, Chris; Lehner, Nicolas; Lockman, Felix; wotta, Christopher

2018-01-01

The nearby spiral galaxy M31 contains an extensive gaseous circumgalactic medium (CGM) that is being studied in project AMIGA, a large HST program to obtain UV spectroscopy of the CGM in absorption against background AGN. As part of this project, sensitive HI 21cm emission observations were made using the Robert C. Byrd Green Bank Telescope (GBT) toward 48 AGN at impact parameters between 25 kpc and 340 kpc. No emission was detected to a 5-sigma limit on log(NHI) of 17.6 cm-2 (Howk et al 2017, ApJ, 846, 141). We now report on a search for HI emission in 1x1 degree fields around 8 of the AGN to 5-sigma limits on log(NHI) of 17.9 cm-2. The new observations cover ~10 times the area of the M31 CGM covered by the Howk et al pointings, though at somewhat reduced sensitivity. Again, no HI emission was detected with the exception of the "Davies Cloud", a high-velocity cloud of M31 that has been known for some time. We will discuss the absence of significant HI emission in the context of the COS-Halos study of 44 galaxies at z~0.2, and how this finding may relate to the existence of HI clouds between M31 and M33 (Wolfe et al. 2016, ApJ, 816, 81).The GBT is a facility of the National Science Foundation, operated under a cooperative agreement by Associated Universities, Inc.

Effect of newly synthesized compounds 44Bu and 444 on QRS -complex width and fast sodium current

Czech Academy of Sciences Publication Activity Database

Kilianová, A.; Bébarová, M.; Beránková, K.; Opatřilová, R.; Pásek, Michal; Bartošová, L.

2010-01-01

Roč. 79, č. 1 (2010), s. 41-49 ISSN 0001-7213 Institutional research plan: CEZ:AV0Z20760514 Keywords : 444 * 44Bu * QRS-complex * sodium current * rat Subject RIV: BO - Biophysics Impact factor: 0.534, year: 2010

44 CFR 206.343 - Scope.

Science.gov (United States)

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Scope. 206.343 Section 206.343 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND...; (2) Crisis counseling; (3) Disaster Legal services; and (4) Disaster unemployment assistance. ...

44 CFR 6.2 - Definitions.

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2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Definitions. 6.2 Section 6.2 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY... those concerning education, financial transactions, medical history, and criminal or employment history...

44 CFR 17.605 - Definitions.

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2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Definitions. 17.605 Section 17.605 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) § 17.605 Definitions...

44 CFR 354.3 - Definitions.

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2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Definitions. 354.3 Section 354.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS FEE FOR SERVICES TO SUPPORT FEMA'S OFFSITE RADIOLOGICAL EMERGENCY PREPAREDNESS...

44 CFR 352.1 - Definitions.

Science.gov (United States)

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Definitions. 352.1 Section 352.1 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS COMMERCIAL NUCLEAR POWER PLANTS: EMERGENCY PREPAREDNESS PLANNING § 352.1 Definitions...

Flow mode analysis by Imatron C100 of 44 focal liver tumors

International Nuclear Information System (INIS)

Simon-Karneff, J.; Hernigou, A.; Grataloup, C.; Charpentier, A.; Bouillot, J.L.; Plainfosse, M.C.

1994-01-01

We studied 44 patients with focal benign (n = 13) or malignant (n = 31) liver tumors proved by histology or follow-up. The flow mode was acquired by electron beam CT (EBCT) after injection (35 cc at 6 ml/sec): 20 slices with a 400 ms exposure time. We looked for abnormal vessels and density curves inside the tumor, liver and aorta. We describe arterial vascularization in most cases (type 1) and particularly in all the hepatocarcinomas (n = 15) associated with abnormal vessels, and also in rare tumors (n = 4). For benign lesions like angiomas (n = 9) we showed surrounding the mass arterial vascularization in add to the typical aspect (type 3); for nodular hyperplasia (n = 3) arterial blush was associated with the last part of the tumoral curve at the same level as liver. Most often metastasis (n = 13) had no central vascularization and a slight peripheral density increased (type 2). Flow mode by EBCT allows a good density curves analysis particularly at arterial time. (authors). 20 refs., 12 figs

MCNP4c JEFF-3.1 Based Libraries. Eccolib-Jeff-3.1 libraries; Les bibliotheques Eccolib-Jeff-3.1

Energy Technology Data Exchange (ETDEWEB)

Sublet, J.Ch

2006-07-01

Continuous-energy and multi-temperatures MCNP Ace types libraries, derived from the Joint European Fusion-Fission JEFF-3.1 evaluations, have been generated using the NJOY-99.111 processing code system. They include the continuous-energy neutron JEFF-3.1/General Purpose, JEFF-3.1/Activation-Dosimetry and thermal S({alpha},{beta}) JEFF-3.1/Thermal libraries and data tables. The processing steps and features are explained together with the Quality Assurance processes and records linked to the generation of such multipurpose libraries. (author)

Four Years of Media Habits: Implications for U.S. Army Advertising to the Prime Market

Science.gov (United States)

1988-12-01

X NBA Basketball NSA BASKETBALL X X College Basketball COLLEGE BASKETBALL X X College Basketball Playoffs COLLEGE PLAYOFFS NHL Hockey NHL HOCKEY x x...BASEBALLO 19.65 23.16 21.03 23.73 BASEBALL PLAYOFFS 29.28 32.54 28.79 31.53 WORLD SERIES 44.19 46.61 38.01 48.79 NBA BASKETBALL 20.26 27.41 20.67...SERIES 47.64 46.46 46.57 43.33 NBA BASKETBALL 34.60 39.40 45.32 63.33 COLLEGE BASKETBALL 31.50 35.63 41.09 53.33 COLLEGE PLAYOFFSO NHL HOCKEYb 12.07

Aberrant Splicing of Estrogen Receptor, HER2, and CD44 Genes in Breast Cancer

Directory of Open Access Journals (Sweden)

Kazushi Inoue

2015-01-01

Full Text Available Breast cancer (BC is the most common cause of cancer-related death among women under the age of 50 years. Established biomarkers, such as hormone receptors (estrogen receptor [ER]/progesterone receptor and human epidermal growth factor receptor 2 (HER2, play significant roles in the selection of patients for endocrine and trastuzumab therapies. However, the initial treatment response is often followed by tumor relapse with intrinsic resistance to the first-line therapy, so it has been expected to identify novel molecular markers to improve the survival and quality of life of patients. Alternative splicing of pre-messenger RNAs is a ubiquitous and flexible mechanism for the control of gene expression in mammalian cells. It provides cells with the opportunity to create protein isoforms with different, even opposing, functions from a single genomic locus. Aberrant alternative splicing is very common in cancer where emerging tumor cells take advantage of this flexibility to produce proteins that promote cell growth and survival. While a number of splicing alterations have been reported in human cancers, we focus on aberrant splicing of ER , HER2 , and CD44 genes from the viewpoint of BC development. ERα36 , a splice variant from the ER1 locus, governs nongenomic membrane signaling pathways triggered by estrogen and confers 4-hydroxytamoxifen resistance in BC therapy. The alternative spliced isoform of HER2 lacking exon 20 (Δ16HER2 has been reported in human BC; this isoform is associated with transforming ability than the wild-type HER2 and recapitulates the phenotypes of endocrine therapy-resistant BC. Although both CD44 splice isoforms ( CD44s , CD44v play essential roles in BC development, CD44v is more associated with those with favorable prognosis, such as luminal A subtype, while CD44s is linked to those with poor prognosis, such as HER2 or basal cell subtypes that are often metastatic. Hence, the detection of splice variants from these loci

12 CFR 25.44 - Public notice by banks.

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2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Public notice by banks. 25.44 Section 25.44... Public notice by banks. A bank shall provide in the public lobby of its main office and each of its branches the appropriate public notice set forth in appendix B of this part. Only a branch of a bank having...

12 CFR 228.44 - Public notice by banks.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Public notice by banks. 228.44 Section 228.44... notice by banks. A bank shall provide in the public lobby of its main office and each of its branches the appropriate public notice set forth in appendix B of this part. Only a branch of a bank having more than one...

Outdoor stocking density in free-range laying hens: radio-frequency identification of impacts on range use.

Science.gov (United States)

Campbell, D L M; Hinch, G N; Dyall, T R; Warin, L; Little, B A; Lee, C

2017-01-01

The number and size of free-range laying hen (Gallus gallus domesticus) production systems are increasing within Australia in response to consumer demand for perceived improvement in hen welfare. However, variation in outdoor stocking density has generated consumer dissatisfaction leading to the development of a national information standard on free-range egg labelling by the Australian Consumer Affairs Ministers. The current Australian Model Code of Practice for Domestic Poultry states a guideline of 1500 hens/ha, but no maximum density is set. Radio-frequency identification (RFID) tracking technology was used to measure daily range usage by individual ISA Brown hens housed in six small flocks (150 hens/flock - 50% of hens tagged), each with access to one of three outdoor stocking density treatments (two replicates per treatment: 2000, 10 000, 20 000 hens/ha), from 22 to 26, 27 to 31 and 32 to 36 weeks of age. There was some variation in range usage across the sampling periods and by weeks 32 to 36 individual hens from the lowest stocking density on average used the range for longer each day (Prange with 2% of tagged hens in each treatment never venturing outdoors and a large proportion that accessed the range daily (2000 hens/ha: 80.5%; 10 000 hens/ha: 66.5%; 20 000 hens/ha: 71.4%). On average, 38% to 48% of hens were seen on the range simultaneously and used all available areas of all ranges. These results of experimental-sized flocks have implications for determining optimal outdoor stocking densities for commercial free-range laying hens but further research would be needed to determine the effects of increased range usage on hen welfare.

α6 Integrin and CD44 enrich for a primary keratinocyte population that displays resistance to UV-induced apoptosis.

Directory of Open Access Journals (Sweden)

Helen Wray

Full Text Available Epidermal human keratinocytes are exposed to a wide range of environmental genotoxic insults, including the UV component of solar radiation. Epidermal homeostasis in response to cellular or tissue damage is maintained by a population of keratinocyte stem cells (KSC that reside in the basal layer of the epithelium. Using cell sorting based on cell-surface markers, we have identified a novel α6 integrin(high+/CD44(+ sub-population of basal keratinocytes. These α6 integrin(high+/CD44(+ keratinocytes have both high proliferative potential, form colonies in culture that have characteristics of holoclones and have a unique pattern of resistance to apoptosis induced by UVB radiation or by agents that induce single- or double strand DNA breaks. Resistance to UVB induced apoptosis in the α6 integrin(high+/CD44(+ cells involved increased expression of TAp63 and was overcome by PI-3 kinase inhibition. In marked contrast, the α6 integrin(high+/CD44(+ cells were sensitive to apoptosis induced by the cross-linking agent cisplatin, and imatinib inhibition of c-Abl blocked the ability of cisplatin to kill α6 integrin(high+/CD44(+ cells. Our findings reveal a population of basal keratinocytes with long-term proliferative properties that display specific patterns of apoptotic resistance that is dependent upon the genotoxic stimulus, and provide insights into how these cells can be targeted with chemotherapeutic agents.

Assessment of the biosorption characteristics of a macro-fungus for the decolorization of Acid Red 44 (AR44) dye

International Nuclear Information System (INIS)

Akar, Tamer; Tosun, Ilknur; Kaynak, Zerrin; Kavas, Emine; Incirkus, Gonul; Akar, Sibel Tunali

2009-01-01

This study focuses on the possible use of macro-fungus Agaricus bisporus to remove Acid Red 44 dye from aqueous solutions. Batch equilibrium studies were carried out as a function of pH, biomass amount, contact time and temperature to determine the decolorization efficiency of biosorbent. The highest dye removal yield was achieved at pH 2.0. Equilibrium occurred within about 30 min. Biosorption data were successfully described by Langmuir isotherm model and the pseudo-second-order kinetic model. The maximum monolayer biosorption capacity of biosorbent material was found as 1.19 x 10 -4 mol g -1 . Thermodynamic parameters indicated that the biosorption of Acid Red 44 onto fungal biomass was spontaneous and endothermic in nature. Fourier transform infrared spectroscopy and scanning electron microscopy were used for the characterization of possible dye-biosorbent interaction and surface structure of biosorbent, respectively. Finally the proposed biosorbent was successfully used for the decolorization of Acid Red 44 in synthetic wastewater conditions.

44 CFR 5.3 - Definitions.

Science.gov (United States)

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Definitions. 5.3 Section 5.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY... means all books, papers, maps, photographs, or other documentary materials, regardless of physical form...

44 CFR 17.600 - Purpose.

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2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Purpose. 17.600 Section 17.600 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) § 17.600 Purpose. (a) The...

44 CFR 19.450 - Athletics.

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2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Athletics. 19.450 Section 19.450 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND... hockey, football, basketball, and other sports the purpose or major activity of which involves bodily...

44 CFR 15.2 - Definitions.

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2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Definitions. 15.2 Section 15.2 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL CONDUCT AT THE MT. WEATHER EMERGENCY ASSISTANCE CENTER AND AT THE NATIONAL EMERGENCY...

44 CFR 350.2 - Definitions.

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2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Definitions. 350.2 Section 350.2 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS REVIEW AND APPROVAL OF STATE AND LOCAL RADIOLOGICAL EMERGENCY PLANS AND PREPAREDNESS...

31 CFR 346.5 - Limitation on holdings.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Limitation on holdings. 346.5 Section 346.5 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE... deducted in any one year be in equal amounts. While it is permissible for an eligible married couple to...

No postnatal doubling of number of neurons in human Broca's areas (Brodmann areas 44 and 45)? A stereological study.

Science.gov (United States)

Uylings, H B M; Malofeeva, L I; Bogolepova, I N; Jacobsen, A M; Amunts, K; Zilles, K

2005-01-01

In this study we explored whether a postnatal doubling of the total number of neurons occurs in the human Brodmann areas 44 and 45 (Broca's area). We describe the most recent error prediction formulae and their application for the modern stereological estimators for volume and number of neurons. We estimated the number of neurons in 3D optical disector probes systematically random sampled throughout the entire Brodmann areas (BA) 44 and 45 in developing and young adult cases. In the relatively small number of male and female cases studied no substantial postnatal increase in total number of neurons occurred in areas 44 and 45; the volume of these areas reached adult values around 7 years. In addition, we did find indications that a shift from a right-over-left to a left-over-right asymmetry may occur in the volume of BA 45 during postnatal development. No major asymmetry in total number of neurons in BA 44 and 45 was detected.

40 CFR 81.44 - Metropolitan Memphis Interstate Air Quality Control Region.

Science.gov (United States)

2010-07-01

... Quality Control Region. 81.44 Section 81.44 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Air Quality Control Regions § 81.44 Metropolitan Memphis Interstate Air Quality Control Region. The Metropolitan Memphis Interstate Air Quality Control Region (Arkansas-Mississippi-Tennessee) consists of the...

Gender difference in 2-year mortality and immunological response to ART in an HIV-infected Chinese population, 2006-2008.

Science.gov (United States)

Dou, Zhihui; Xu, Jiahong; Jiao, Jin Hua; Ma, Ye; Durako, Stephen; Yu, Lan; Zhao, Yan; Zhang, Fujie

2011-01-01

Since it was initiated in 2002, the China Free Antiretroviral Treatment (ART) Program has been progressing from an emergency response to a standardized treatment and care system. As of December 31, 2009, a total of 81,880 patients in 31 provinces, autonomous regions, and special municipalities received free ART. Gender differences, however, in mortality and immunological response to ART in this cohort have never been described. To understand whether women and men who enrolled in the China National Free ART Program responded equally well to the treatment. A retrospective analysis of the national free ART databases from June 2006-December 2008 was performed. HIV-infected subjects who were 18 years or older, ART naïve at baseline, and on a 3TC regimen enrolled in the program from June 1 to December 31, 2006, were included in this study, then followed up to 2 years. Among 3457 enrolled subjects who met the inclusion criteria, 59.2% were male and 40.8% female. The majority of the subjects were 19-44 years old (77%) and married (72%). Over the full 24 months of follow-up, the mortality rate was 19.0% in males and 11.4% in females (p = 0.0014). Males on therapy for 3-24 months were more likely to die than females (HR = 1.46, 95% CI: 1.04-2.06, p = 0.0307) after adjusting for baseline characteristics. Compared to men, women had higher CD4+ counts over time after initiating ART (p<0.0001). Our study showed that women had an overall lower mortality and higher CD4+ counts than men in response to ART treatment, which may be attributed to adherence, biological factors, social, cultural and economic reasons. Further study is needed to explore these factors that might contribute to the gender differences in mortality and immunological response to ART.

Crystal structure of 4,4′-bis[3-(piperidin-1-ylprop-1-yn-1-yl]-1,1′-biphenyl

Directory of Open Access Journals (Sweden)

Anqi Walbaum

2017-06-01

Full Text Available The title compound, C28H32N2, (I, is one of a second generation of compounds designed and synthesized based on a very potent and selective α9α10 nicotinic acetylcholine receptor antagonist ZZ161C {1,1′-[[1,1′-biphenyl]-4,4′-diylbis(prop-2-yne-3,1-diyl]bis(3,4-dimethylpyridin-1-ium bromide}, which has shown analgesic effects in a chemotherapy-induced neuropathy animal model. Compound (I was synthesized by the reaction of 4,4′-bis(3-bromoprop-1-yn-1-yl-1,1′-biphenyl with piperidine at room temperature in acetonitrile. The single-crystal used for X-ray analysis was obtained by dissolving (I in a mixture of dichloromethane and methanol, followed by slow evaporation of the solvent. In the crystal of (I, the biphenyl moiety has a twisted conformation, with a dihedral angle of 25.93 (4° between the benzene rings. Both piperidine head groups in (I are in the chair conformation and are oriented so that the N-atom lone pairs of each piperidine group point away from the central biphenyl moiety.

Expression of two isoforms of CD44 in human endometrium.

Science.gov (United States)

Behzad, F; Seif, M W; Campbell, S; Aplin, J D

1994-10-01

The distribution of the cell-surface adhesion glycoprotein CD44 in human endometrium was examined by immunofluorescence using six monoclonal antibodies to epitopes common to all forms of the molecule, and by reverse transcription-polymerase chain reaction (RT-PCR). Immunoreactivity was observed throughout the menstrual cycle in stroma, vessels, glandular, and luminal epithelium. Variations in staining intensity were observed, especially in the epithelial compartment. CD44 was also expressed strongly by decidualized stromal cells of first-trimester pregnancy. No systematic variation of immunoreactivity was observed with stages of the normal cycle, but a fraction (25%) of the specimens lacked reactivity in the epithelium. To determine the molecular size of the epithelial isoform, an immunoprecipitation technique was developed using surface-radioiodinated, detergent-extracted glands. This indicated the presence at the cell surface of a single dominant CD44E species with an approximate molecular mass of 130 kDa. RT-PCR was used to investigate the isoforms present in whole endometrial tissue, isolated gland fragments, and Ishikawa endometrial carcinoma cells. Complementary DNA produced from total endometrial mRNA was PCR-amplified across the splice junction between exons 5 and 15. Transcripts corresponding to the hyaluronate receptor CD44H as well as a larger isoform were identified. CD44H was absent, or very scarce, in cDNA from purified gland epithelium. In contrast, Ishikawa cells expressed this form abundantly. The glands and Ishikawa cells also expressed CD44E containing sequences encoded by exons 12, 13, and 14. These data demonstrate the presence of CD44 in human endometrium and decidua, and show that different isoforms of CD44 are associated with tissue compartments in which different functional roles can be anticipated.

44 CFR 334.1 - Purpose.

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2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Purpose. 334.1 Section 334.1 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY... proceed with specific responses to an identified crisis or emergency. (c) Provides guidance to the Federal...

44 CFR 9.2 - Policy.

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2010-10-01

... Agency to provide leadership in floodplain management and the protection of wetlands. Further, the Agency... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Policy. 9.2 Section 9.2 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY...

44 CFR 5.2 - Application.

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2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Application. 5.2 Section 5.2 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL PRODUCTION OR DISCLOSURE OF INFORMATION General Provisions § 5.2 Application. This part applies to...

44 CFR 19.200 - Application.

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2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Application. 19.200 Section 19.200 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 19.200 Application. Except as provided in §§ 19.205...

44 CFR 16.102 - Application.

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2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Application. 16.102 Section 16.102 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... ACTIVITIES CONDUCTED BY THE FEDERAL EMERGENCY MANAGEMENT AGENCY § 16.102 Application. This regulation (§§ 16...

44 CFR 327.5 - Reports.

Science.gov (United States)

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Reports. 327.5 Section 327.5 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY... Reports. Such reports of operations under this order as may be required by the Federal Emergency...

19 CFR 12.44 - Disposition.

Science.gov (United States)

2010-04-01

... SPECIAL CLASSES OF MERCHANDISE Merchandise Produced by Convict, Forced, Or Indentured Labor § 12.44... proceedings pursuant to part 162, subpart E, of this chapter. (c) Prison-labor goods. Nothing in this chapter... concerning prison-labor goods. [T.D. 00-52, 65 FR 45875, July 26, 2000] ...

44 CFR 10.7 - Planning.

Science.gov (United States)

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Planning. 10.7 Section 10.7... GENERAL ENVIRONMENTAL CONSIDERATIONS Agency Implementing Procedures § 10.7 Planning. (a) Early planning. The Regional Administrator shall integrate the NEPA process with other planning at the earliest...

44 CFR 19.540 - Advertising.

Science.gov (United States)

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Advertising. 19.540 Section 19.540 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... Programs or Activities Prohibited § 19.540 Advertising. A recipient shall not in any advertising related to...

27 CFR 44.146 - Closing.

Science.gov (United States)

2010-04-01

... PAYMENT OF TAX, OR WITH DRAWBACK OF TAX Operations by Export Warehouse Proprietors Inventories § 44.146 Closing. A closing inventory shall be made by the export warehouse proprietor when he transfers ownership or concludes business. Where the proprietor transfers ownership the closing inventory shall be made...

INL Seismic Monitoring Annual Report: January 1, 2011 - December 31, 2011

Energy Technology Data Exchange (ETDEWEB)

S. J. Payne; J. M. Hodges; R. G. Berg; D. F. Bruhn

2012-12-01

During 2011, the Idaho National Laboratory Seismic Monitoring Program evaluated 21,928 independent triggers that included earthquakes from around the world, the western United States, and local region of the Snake River Plain. Seismologists located 2,063 earthquakes and man-made blasts within and near the 161-km (or 100-mile) radius of the Idaho National Laboratory. Of these events, 16 were small-to-moderate size earthquakes ranging in magnitude (M) from 3.0 to 4.4. Within the 161-km radius, the majority of 941 earthquakes (M < 4.4) occurred in the active regions of the Basin and Range Province with only six microearthquakes occurring in the Snake River Plain. In the northern and southeastern Basin and Range, eight earthquake swarms occurred and included over 325 events. Five of the Snake River Plain earthquakes were located within and near the northern and southern ends of the Great Rift volcanic rift zone. All have anomalously deep focal depths (16 to 38 km) and waveforms indicative of fluid movement at mid- and lower-crustal levels and are a continuation of activity observed at Craters of the Moon National Monument since 2007. Since 1972, the Idaho National Laboratory has recorded 55 small-magnitude microearthquakes (M = 2.2) within the eastern Snake River Plain and 25 deep microearthquakes (M = 2.3) in the vicinity of Craters of the Moon National Monument.

A Peripheral Ameloblastic Fibro-Odontoma in a 3-Year-Old Girl: Case Report, Immunohistochemical Analysis, and Literature Review

Directory of Open Access Journals (Sweden)

Yi-Chun Lin

2014-01-01

Full Text Available Ameloblastic fibro-odontoma (AFO predominantly occurs in the jaw bones of children and young adults. Extraosseous AFO is extremely rare. We describe a peripheral ameloblastic fibro-odontoma in the maxillary gingiva of a 3-year-old girl. The clinical appearance resembled fiery red reactive gingival lesions. The histopathological examination of the excised lesion showed small islands and cords of odontogenic epithelium with cellular myxoid stroma in the subepithelial tissue. The mass contained calcified material and an enamel-like deposit. Many small blood vessels appeared in the connective tissue surrounding the odontogenic epithelium. The immunohistochemical assays showed strong reactivity for amelogenin, β-catenin, CD44, and CD31 in the tissue sections. There was no recurrence after the 1-year follow-up. Because this lesion clinically resembles other nonneoplastic lesions and is very rare in gingiva, establishing a correct diagnosis is achieved only based on specific histological characteristics. Conservative excision of the tumor is the treatment of choice.

40 CFR 425.44 - New source performance standards (NSPS).

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false New source performance standards (NSPS). 425.44 Section 425.44 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS LEATHER TANNING AND FINISHING POINT SOURCE CATEGORY Retan-Wet Finish-Sides...

Family affluence, socio - economic status and dietary habits of 1st year University students

Directory of Open Access Journals (Sweden)

Eirini Syligardou

2016-03-01

Full Text Available Introduction: Low socio-economic status (SES is associated with health risk behaviours contributing to the social inequalities in health. However, the associations of dietary habits with socio-economic status have not been investigated in emerging adulthood in detail yet. Aim: To investigate the associations of dietary habits with socio-economic status in 1st year undergraduate university students. Methods: This cross-sectional analysis draws data from the LATO study, a longitudinal study of all 1st year undergraduate students of TEI Crete during the academic year 2012/13 (Ν=1138, 54% girls, Mean age 18,31 years, response rate 96,7%. The consumption frequencies of fruits, vegetables, soft drinks, breakfast and delivery food were associated with the following socio-economic indicators: Family affluence (FAS II, paternal and maternal educational level and self-reported economic status. The SPSS v21.0 was used to perform logistic regression models after adjusting for potential confounders. Results: Only 24,9%, 12% and 17% of the students were consuming breakfast, fruits and vegetables, respectively, in a daily basis. Soft drinks were consumed daily by 6,1% of the participants but most of them consumed delivery/junk food less than 1/week (73,8%. Higher family affluence was associated with increased odds of consuming breakfast (OR=2,90, 95%CI=1,13-7,44, soft drinks (OR=8,10, 95%CI=1,38-47,68 and delivery/junk food (OR=2,44, 95%CI=1,27-4,70 in boys. High paternal educational level was associated in a protective way with boys’ consumption of delivery food (OR=0,42, 95%CI=0,18-0,95 and soft drinks (OR=0,19, 95%CI=0,05-0,72. Fruits and vegetables consumption was not associated with any SES indicator. Conclusions: The majority of 1st year university students were not following current diet recommendations irrespective of SES. Interventions targeting eating behaviours are needed at higher education institutes.

Recommendations from the External Auditors to the CERN Pension Fund Management on the Annual Report and Financial Statements for the Year Ended 31 December 2016 and Comments from the CERN Pension Fund Management

CERN Document Server

2017-01-01

Recommendations from the External Auditors to the CERN Pension Fund Management on the Annual Report and Financial Statements for the Year Ended 31 December 2016 and Comments from the CERN Pension Fund Management

Recommendations from the External Auditors to the CERN Pension Fund Management on the Annual Report and Financial Statements for the year ended 31 December 2015 and comments from the CERN Pension Fund Management

CERN Document Server

2016-01-01

Recommendations from the External Auditors to the CERN Pension Fund Management on the Annual Report and Financial Statements for the year ended 31 December 2015 and comments from the CERN Pension Fund Management

28 CFR 104.44 - Determination of presumed noneconomic losses for decedents.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Determination of presumed noneconomic losses for decedents. 104.44 Section 104.44 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) SEPTEMBER 11TH VICTIM COMPENSATION FUND OF 2001 Amount of Compensation for Eligible Claimants. § 104.44...

Preoperative factors and 3-year weight change in the Longitudinal Assessment of Bariatric Surgery (LABS) consortium.

Science.gov (United States)

Courcoulas, Anita P; Christian, Nicholas J; O'Rourke, Robert W; Dakin, Greg; Patchen Dellinger, E; Flum, David R; Melissa Kalarchian, Ph D; Mitchell, James E; Patterson, Emma; Pomp, Alfons; Pories, Walter J; Spaniolas, Konstantinos; Steffen, Kristine; Wolfe, Bruce M; Belle, Steven H

2015-01-01

Limited data guide the prediction of weight loss success or failure after bariatric surgery according to presurgery factors. There is significant variation in weight change after bariatric surgery and much interest in identifying preoperative factors that may contribute to these differences. This report evaluates the associations of a comprehensive set of baseline factors and 3-year weight change. Ten hospitals in 6 geographically diverse clinical centers in the United States. Adults undergoing a first bariatric surgical procedure as part of clinical care by participating surgeons were recruited between 2006 and 2009. Participants completed research assessments utilizing standardized and detailed data collection on over 100 preoperative and operative parameters for individuals undergoing Roux-en-Y gastric bypass (RYGB) and laparoscopic adjustable gastric banding (LAGB). Weight was measured 3 years after surgery. Percent weight change for RYGB or LAGB from baseline to 3 years was analyzed as both a continuous and dichotomous outcome with cut points at 25% for RYGB and 10% for LAGB. Multivariable linear and logistic regression models were used to identify independent baseline predictors of the continuous and categorical outcomes, respectively. The median weight loss 3 years after surgery for RYGB (n = 1513) participants was 31.5% (IQR: 24.6%-38.4%; range, 59.2% loss to .9% gain) of baseline weight and 16.0% (IQR: 8.1%-23.1%; range, 56.1% loss to 12.5% gain) for LAGB (n = 509) participants. The median age was 46 years for RYGB and 48 years for LAGB; 80% of RYGB participants and 75% of LAGB participants were female; and the median baseline body mass index (BMI) was 46 kg/m(2) for RYGB and 44 kg/m(2) for LAGB. For RYGB, black participants lost 2.7% less weight compared with whites and participants with diabetes at baseline had 3.7% less weight loss at year 3 than those without diabetes at baseline. There were small but statistically significant differences in weight

Preoperative Factors and Three Year Weight Change in the Longitudinal Assessment of Bariatric Surgery (LABS) Consortium

Science.gov (United States)

Courcoulas, Anita P.; Christian, Nicholas J.; O’Rourke, Robert W.; Dakin, Greg; Dellinger, E. Patchen; Flum, David Reed; Kalarchian, Melissa; Mitchell, James E.; Patterson, Emma; Pomp, Alfons; Pories, Walter J.; Spaniolas, Konstantinos; Steffen, Kristine; Wolfe, Bruce M.; Belle, Steven H.

2015-01-01

BACKGROUND Limited data guide the prediction of weight loss success or failure following bariatric surgery according to pre-surgery factors. There is significant variation in weight change following bariatric surgery and much interest in identifying pre-operative factors that may contribute to these differences. OBJECTIVE This report evaluates the associations of a comprehensive set of baseline factors and three-year weight change. SETTING Ten hospitals in six geographically diverse clinical centers in the United States. METHODS: PARTICIPANTS and INTERVENTIONS Adults undergoing a first bariatric surgical procedure as part of clinical care by participating surgeons were recruited between 2006 and 2009. Participants completed research assessments utilizing standardized and detailed data collection on over 100 preoperative and operative parameters for individuals undergoing Roux-en-Y gastric bypass (RYGB) and laparoscopic adjustable gastric banding (LAGB). Weight was measured 3 years following surgery. METHODS: MAIN OUTCOME MEASURES Percent weight change for RYGB or LAGB from baseline to 3 years was analyzed as both a continuous and dichotomous outcome with cut points at 25% for RYGB and 10% for LAGB. Multivariable linear and logistic regression models were used to identify independent baseline predictors of the continuous and categorical outcomes, respectively. RESULTS The median weight loss 3 years following surgery for RYGB (n=1513) participants was 31.5% (IQR: 24.6%–38.4%; range, 59.2% loss to 0.9% gain) of baseline weight and 16.0% (IQR: 8.1%–23.1%; range, 56.1% loss to 12.5% gain) for LAGB (n=509) participants. The median age was 46 years for RYGB and 48 years for LAGB; 80% of RYGB participants and 75% of LAGB participants were female; and the median baseline Body Mass Index (BMI) was 46 kg/m2 for RYGB and 44 kg/m2 for LAGB. For RYGB, Black participants lost 2.7% less weight compared to Whites and participants with diabetes at baseline had 3.7% less weight

US EPA's SPECIATE 4.4 Database: Development and Uses

Science.gov (United States)

SPECIATE is the U.S. Environmental Protection Agency’s (EPA) repository of volatile organic gas and particulate matter (PM) speciation profiles of air pollution sources. EPA released SPECIATE 4.4 in early 2014 and, in total, the SPECIATE 4.4 database includes 5,728 PM, volatile o...

EPA’s SPECIATE 4.4 Database:Development and Uses

Science.gov (United States)

SPECIATE is the U.S. Environmental Protection Agency's (EPA)repository of volatile organic gas and particulate matter (PM) speciation profiles for air pollution sources. EPA released SPECIATE 4.4 in early 2014 and, in total, the SPECIATE 4.4 database includes 5,728 PM, VOC, total...

Expression of CD44 splice variants in human primary brain tumors

NARCIS (Netherlands)

Kaaijk, P.; Troost, D.; Morsink, F.; Keehnen, R. M.; Leenstra, S.; Bosch, D. A.; Pals, S. T.

1995-01-01

Expression of CD44, particularly of certain splice variants, has been linked to tumor progression and metastatic potential in a number of different animal and human cancers. Although differential expression of CD44 standard epitopes (CD44s) in human brain tumors has been reported, the expression of

32 CFR 2001.44 - Reciprocity of use and inspection of facilities.

Science.gov (United States)

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Reciprocity of use and inspection of facilities. 2001.44 Section 2001.44 National Defense Other Regulations Relating to National Defense INFORMATION... INFORMATION Safeguarding § 2001.44 Reciprocity of use and inspection of facilities. (a) Once a facility is...

44 CFR 331.2 - Policy.

Science.gov (United States)

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Policy. 331.2 Section 331.2 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY..., and to make the best use of our natural, industrial and labor resources in order to achieve the...

44 CFR 68.11 - Determination.

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2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Determination. 68.11 Section... § 68.11 Determination. The board shall render its written decision within 45 days after the conclusion... Administrator for review and approval. The Administrator shall make the final base flood elevation determination...

48 CFR 44.302 - Requirements.

Science.gov (United States)

2010-10-01

... during the next 12 months, perform a review to determine if a CPSR is needed. Sales include those... SUBCONTRACTING POLICIES AND PROCEDURES Contractors' Purchasing Systems Reviews 44.302 Requirements. (a) The ACO..., and the volume, complexity and dollar value of subcontracts. If a contractor's sales to the Government...

44 CFR 321.8 - Reports.

Science.gov (United States)

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Reports. 321.8 Section 321.8... ADMINISTRATION) § 321.8 Reports. The Department of Defense, Department of Energy, and Maritime Administration shall furnish the Administrator of the Federal Emergency Management Agency with reports on items and...

44 CFR 19.310 - Recruitment.

Science.gov (United States)

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Recruitment. 19.310 Section... RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 19.310 Recruitment. (a) Nondiscriminatory recruitment. A recipient to which §§ 19.300 through 19...

44 CFR 19.510 - Recruitment.

Science.gov (United States)

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Recruitment. 19.510 Section... Programs or Activities Prohibited § 19.510 Recruitment. (a) Nondiscriminatory recruitment and hiring. A recipient shall not discriminate on the basis of sex in the recruitment and hiring of employees. Where a...

44 CFR 73.2 - Definitions.

Science.gov (United States)

2010-10-01

... measures such as those defined as Flood plain management regulations in § 59.1 of this subchapter. Such... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Definitions. 73.2 Section 73.2 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND...

44 CFR 206.434 - Eligibility.

Science.gov (United States)

2010-10-01

... wetlands management practices; and (ii) No new structure(s) will be built on the property except as... designated area; (3) Be in conformance with 44 CFR part 9, Floodplain Management and Protection of Wetlands..., recreational, or wetlands management usage and proper floodplain management policies and practices, which the...

44 CFR 18.105 - Definitions.

Science.gov (United States)

2010-10-01

... services in the private sector. (o) Recipient includes all contractors, subcontractors at any tier, and... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Definitions. 18.105 Section... HOMELAND SECURITY GENERAL NEW RESTRICTIONS ON LOBBYING General § 18.105 Definitions. For purposes of this...

Mineralization Effect of Hyaluronan on Dental Pulp Cells via CD44.

Science.gov (United States)

Chen, Kuan-Liang; Yeh, Ying-Yi; Lung, Jrhau; Yang, Yu-Chi; Yuan, Kuo

2016-05-01

CD44 is a cell-surface glycoprotein involved in various cellular functions. Recent studies have suggested that CD44 is involved in early mineralization of odontoblasts. Hyaluronic acid (HA) is the principal ligand for receptor CD44. Whether and how HA regulated the mineralization process of dental pulp cells were investigated. The effects of high-molecular-weight HA on differentiation and mineral deposition of dental pulp cells were tested by using alkaline phosphatase (ALP) activity assay and alizarin red S staining. Osteogenesis real-time polymerase chain reaction array, quantitative polymerase chain reaction, and Western blotting were performed to identify downstream molecules involved in the mineralization induction of HA. CD44 was knocked down and examined to confirm whether the mineralization effect of HA was mediated by receptor CD44. Immunohistochemistry was used to understand the localization patterns of CD44 and the identified downstream proteins in vivo. Pulse treatment of HA enhanced ALP activity and mineral deposition in dental pulp cells. Tissue-nonspecific ALP, bone morphogenetic protein 7 (BMP7), and type XV collagen (Col15A1) were upregulated via the HA-CD44 pathway in vitro. Immunohistochemistry of tooth sections showed that the staining pattern of BMP7 was very similar to that of CD44. Results of this study indicated that high-molecular-weight HA enhanced early mineralization of dental pulp cells mediated via CD44. The process involved important mineralization-associated molecules including tissue-nonspecific ALP, BMP7, and Col15A1. The findings may help develop new strategies in regenerative endodontics. Copyright © 2016 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.