WorldWideScience

Sample records for ran minehunter vessels

  1. Paint Failures on Ran Minehunter Vessels: The Effect of Surface Condition on Adhesion of Paints to Immersed GRP

    Science.gov (United States)

    1990-10-01

    141 that the use of neopentyl glycol produces laminates with greater blister resistance because the two methyl groups provide steric protection of...It is known that susceptibility of the ester linkage to hydrolysis is also reduced by increasing the size of the glycol unit 1101, e.g. it is clairned

  2. Evaluation and Adaptation of Mine-Hunting Operations with AUVs

    NARCIS (Netherlands)

    Vossen, R. van; Giodini, S.; Hunter, A.J.; Beckers, A.L.D.; Williams, D.F.

    2013-01-01

    The effectiveness and efficiency of mine-hunting operations with autonomous underwater vehicles (AUVs) are greatly influenced by environmental conditions, such as seabed, turbidity, currents, and tides. Therefore accurate environmental information is needed for the planning and evaluation of

  3. Decision Making on AUVs for adaptive minehunting surveys

    NARCIS (Netherlands)

    Giodini, S.; Hunter, A.J.; Naus, H.W.L.; Bakker, B.; Bekers, D.J.; Ditzel, M.; Vossen, R. van; Dugelay, S.; Baralli, F.; Beckers, A.L.D.

    2014-01-01

    Minehunting operations can benefit from the use of Autonomous Underwater Vehicles (AUVs) because these vehicles are able to acquire high-resolution images of the seabed leaving the man out of the minefield. However, because there are severe communication constraints between the AUV and the control

  4. Inter-cellular transport of ran GTPase.

    Directory of Open Access Journals (Sweden)

    Deepak Khuperkar

    Full Text Available Ran, a member of the Ras-GTPase superfamily, has a well-established role in regulating the transport of macromolecules across the nuclear envelope (NE. Ran has also been implicated in mitosis, cell cycle progression, and NE formation. Over-expression of Ran is associated with various cancers, although the molecular mechanism underlying this phenomenon is unclear. Serendipitously, we found that Ran possesses the ability to move from cell-to-cell when transiently expressed in mammalian cells. Moreover, we show that the inter-cellular transport of Ran is GTP-dependent. Importantly, Ran displays a similar distribution pattern in the recipient cells as that in the donor cell and co-localizes with the Ran binding protein Nup358 (also called RanBP2. Interestingly, leptomycin B, an inhibitor of CRM1-mediated export, or siRNA mediated depletion of CRM1, significantly impaired the inter-cellular transport of Ran, suggesting a function for CRM1 in this process. These novel findings indicate a possible role for Ran beyond nucleo-cytoplasmic transport, with potential implications in inter-cellular communication and cancers.

  5. Tackling complex turbulent flows with transient RANS

    NARCIS (Netherlands)

    Kenjeres, S.; Hanjalic, K.

    2009-01-01

    This article reviews some recent applications of the transient-Reynoldsaveraged Navier–Stokes (T-RANS) approach in simulating complex turbulent flows dominated by externally imposed body forces, primarily by thermal buoyancy and the Lorentz force. The T-RANS aims at numerical resolving unsteady

  6. Remote Minehunting System (RMS)

    Science.gov (United States)

    2015-12-01

    1449.4 1449.4 744.6 Confidence Level Confidence Level of cost estimate for current APB: 50% The Independent Cost Estimate to support the RMS Nunn...which the Derpartment has been successful. It is difficult to calculate mathematically the precise confidence levels associated with life-cycle cost...Baseline (TY $M) Initial PAUC Production Estimate Changes PAUC Development Estimate Econ Qty Sch Eng Est Oth Spt Total 12.957 -0.752 3.262 2.950 0.454

  7. Higher-order RANS turbulence models for separated flows

    Data.gov (United States)

    National Aeronautics and Space Administration — Higher-order Reynolds-averaged Navier-Stokes (RANS) models are developed to overcome the shortcomings of second-moment RANS models in predicting separated flows....

  8. Evaluation of energy and cost savings in mobile Cloud RAN

    DEFF Research Database (Denmark)

    Checko, Aleksandra; Christiansen, Henrik Lehrmann; Berger, Michael Stübert

    2013-01-01

    , is sub optimal, comparing to a novel, cloud based architecture called Cloud Radio Access Network (C-RAN). In C-RAN a group of cells shares processing resources, and hence benefit from statistical multiplexing gain is expected. In this paper, the energy and cost savings in C-RAN are evaluated numerically...

  9. Assessment of RANS CFD modelling for pressurised thermal shock analysis

    International Nuclear Information System (INIS)

    Sander M Willemsen; Ed MJ Komen; Sander Willemsen

    2005-01-01

    Full text of publication follows: The most severe Pressurised Thermal Shock (PTS) scenario is a cold water Emergency Core Coolant (ECC) injection into the cold leg during a LOCA. The injected ECC water mixes with the hot fluid present in the cold leg and flows towards the downcomer where further mixing takes place. When the cold mixture comes into contact with the Reactor Pressure Vessel (RPV) wall, it may lead to large temperature gradients and consequently to high stresses in the RPV wall. Knowledge of these thermal loads is important for RPV remnant life assessments. The existing thermal-hydraulic system codes currently applied for this purpose are based on one-dimensional approximations and can, therefore, not predict the complex three-dimensional flows occurring during ECC injection. Computational Fluid Dynamics (CFD) can be applied to predict these phenomena, with the ultimate benefit of improved remnant RPV life assessment. The present paper presents an assessment of various Reynolds Averaged Navier Stokes (RANS) CFD approaches for modeling the complex mixing phenomena occurring during ECC injection. This assessment has been performed by comparing the numerical results obtained using advanced turbulence models available in the CFX 5.6 CFD code in combination with a hybrid meshing strategy with experimental results of the Upper Plenum Test Facility (UPTF). The UPTF was a full-scale 'simulation' of the primary system of the four loop 1300 MWe Siemens/KWU Pressurised Water Reactor at Grafenrheinfeld. The test vessel upper plenum internals, downcomer and primary coolant piping were replicas of the reference plant, while other components, such as core, coolant pump and steam generators were replaced by simulators. From the extensive test programme, a single-phase fluid-fluid mixing experiment in the cold leg and downcomer was selected. Prediction of the mixing and stratification is assessed by comparison with the measured temperature profiles at several locations

  10. Algorithmes de couplage RANS et ecoulement potentiel

    Science.gov (United States)

    Gallay, Sylvain

    -decrochage. L'algorithme de couplage a ete compare a des donnees de plus haute fidelite sur des configurations issues de la litterature. Un modele de fuselage base sur des relations empiriques et des simulations RANS a ete teste et valide. Les coefficients de portance, de trainee et de moment de tangage ainsi que les coefficients de pression extraits le long de l'envergure ont montre un bon accord avec les donnees de soufflerie et les modeles RANS pour des configurations transsoniques. Une configuration a geometrie hypersustentatoire a permis d'etudier la modelisation des surfaces hypersustentees de la methode d'ecoulement potentiel, demontrant que la cambrure peut etre prise en compte uniquement dans les donnees visqueuses.

  11. Cloud RAN for Mobile Networks - a Technology Overview

    DEFF Research Database (Denmark)

    Checko, Aleksandra; Christiansen, Henrik Lehrmann; Yan, Ying

    2014-01-01

    Cloud Radio Access Network (C-RAN) is a novel mobile network architecture which can address a number of challenges the operators face while trying to support growing end-user’s needs. The main idea behind C-RAN is to pool the Baseband Units (BBUs) from multiple base stations into centralized BBU...

  12. The contribution of lexical access speed to RAN and reading

    DEFF Research Database (Denmark)

    Poulsen, Mads

    and reading speed in the older age group was still strong after controlling for general speed of processing, but controlling for confrontation picture naming speed reduced the contribution of RAN to only marginally significant. Conclusions: We conclude that RAN-objects relationship with reading speed......Purpose: The study investigated why and when rapid automatised naming is a predictor of reading. Specifically, we tested the hypotheses that (1) RAN-objects predicts reading because it is a measure of lexical (e.g. phonological) access speed, but (2) that RAN only becomes a predictor of reading...... development once a certain level of phonological recoding proficiency has been reached. Method: Forty Danish students without reading difficulties were administered tests of reading speed and accuracy, phoneme awareness, RAN-objects, timed confrontation picture naming, and visio-motor reaction time...

  13. Vessel Operating Units (Vessels)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains data for vessels that are greater than five net tons and have a current US Coast Guard documentation number. Beginning in1979, the NMFS...

  14. A framework for resources allocation in virtualised C-RAN

    DEFF Research Database (Denmark)

    Al-Samman, Imad; Artuso, Matteo; Christiansen, Henrik Lehrmann

    2016-01-01

    the performance gains of different resource allocation schemes in legacy LTE air interface virtualization. Moreover Cloud — based mobile networks are anticipated to play a significant role for next generation mobile networks. This paper investigates the potential deployment benefits of a novel resource...... virtualization algorithm (Traffic Aware Joint Scheduling) in Cloud-RANs (C-RAN). Air interface resources are coordinated and allocated dynamically by a hypervisor among different virtual operators (VOs). Three distinctive schemes are proposed and evaluated against standard Round Robin (RR) C-RAN scheduling...

  15. Cloud RAN for Mobile Networks - a Technology Overview

    OpenAIRE

    Checko, Aleksandra; Christiansen, Henrik Lehrmann; Yan, Ying; Scolari, Lara; Kardaras, Georgios; Berger, Michael Stübert; Dittmann, Lars

    2014-01-01

    Cloud Radio Access Network (C-RAN) is a novel mobile network architecture which can address a number of challenges the operators face while trying to support growing end-user’s needs. The main idea behind C-RAN is to pool the Baseband Units (BBUs) from multiple base stations into centralized BBU Pool for statistical multiplexing gain, while shifting the burden to the high-speed wireline transmission of In-phase and Quadrature (IQ) data. C-RAN enables energy efficient network operation and pos...

  16. 5th Symposium on Hybrid RANS-LES Methods

    CERN Document Server

    Haase, Werner; Peng, Shia-Hui; Schwamborn, Dieter

    2015-01-01

    This book gathers the proceedings of the Fifth Symposium on Hybrid RANS-LES Methods, which was held on March 19-21 in College Station, Texas, USA. The different chapters, written by leading experts, reports on the most recent developments in flow physics modelling, and gives a special emphasis to industrially relevant applications of hybrid RANS-LES methods and other turbulence-resolving modelling approaches. The book addresses academic researchers, graduate students, industrial engineers, as well as industrial R&D managers and consultants dealing with turbulence modelling, simulation and measurement, and with multidisciplinary applications of computational fluid dynamics (CFD), such as flow control, aero-acoustics, aero-elasticity and CFD-based multidisciplinary optimization. It discusses in particular advanced hybrid RANS-LES methods. Further topics include wall-modelled Large Eddy Simulation (WMLES) methods, embedded LES, and a comparison of the LES methods with both hybrid RANS-LES and URANS methods. ...

  17. Envisioning Spectrum Management in Virtualised C-RAN

    OpenAIRE

    Al-Samman, Imad; Artuso, Matteo; Christiansen, Henrik Lehrmann; Doufexi, Angela; Beach, Mark

    2017-01-01

    Cloud Radio Access Network (C-RAN) has attracted a worldwide attention in both academia and industry. This network architecture re-forming has been considered as a potential solution to meet the increasing capacity demands for future mobile data traffic. In addition, Network Virtualisation is a promising technique for efficient resource utilisation. This paper proposes a customisable resource virtualisation algorithm for multi user data scheduling in a Long Term Evolution (LTE) C- RAN deploym...

  18. Performance Analysis of Several Functional Splits in C-RAN

    OpenAIRE

    Duan , Jialong; Lagrange , Xavier; Guilloud , Frédéric

    2016-01-01

    International audience; Centralized/Cloud Radio Access Network (C-RAN) is a promising future mobile network architecture, which can potentially increase the capacity of mobile network meanwhile reducing operators' cost. In standard C-RAN, frequency shifting is made in Remote Radio Heads (RRHs), which are close to the antennas. Signal processing and upper layers are made in Baseband Unit (BBU) pool for multiple base stations. However, this results in high burden on the optical transport networ...

  19. RanBP3 influences interactions between CRM1 and its nuclear protein export substrates

    OpenAIRE

    Englmeier, Ludwig; Fornerod, Maarten; Bischoff, F. Ralf; Petosa, Carlo; Mattaj, Iain W.; Kutay, Ulrike

    2001-01-01

    We investigated the role of RanBP3, a nuclear member of the Ran-binding protein 1 family, in CRM1-mediated protein export in higher eukaryotes. RanBP3 interacts directly with CRM1 and also forms a trimeric complex with CRM1 and RanGTP. However, RanBP3 does not bind to CRM1 like an export substrate. Instead, it can stabilize CRM1–export substrate interaction. Nuclear RanBP3 stimulates CRM1-dependent protein export in permeabilized cells. These data indicate that RanBP3 functions by a novel mec...

  20. Research vessels

    Digital Repository Service at National Institute of Oceanography (India)

    Rao, P.S.

    The role of the research vessels as a tool for marine research and exploration is very important. Technical requirements of a suitable vessel and the laboratories needed on board are discussed. The history and the research work carried out...

  1. Real-life C-RAN deployment considerations

    DEFF Research Database (Denmark)

    Hansen, Line Maria Pyndt; Ruepp, Sarah Renée; Christiansen, Henrik Lehrmann

    2017-01-01

    procedures and best practices for roll out are yet to be established. This work provides a case study, where a small but densely populated part of the network owned by the Danish mobile network operator, TDC, is evaluated for C-RAN deployment. A roadmap is provided which uses traffic data as input...

  2. Evaluation of Packet Preemption over C-RAN Fronthaul Networks

    DEFF Research Database (Denmark)

    Yan, Ying; Zhou, Zifan; Ruepp, Sarah Renée

    2017-01-01

    The Cloud Radio Access Network (C-RAN) is viewed as a new solution with benefits of reduced cost by sharing resources. This is achieved by the separation of the radio part and the radio processing part, where the transport network between them is referred to as front-haul. It is essential to meet...

  3. Hybrid RANS-LES using high order numerical methods

    Science.gov (United States)

    Henry de Frahan, Marc; Yellapantula, Shashank; Vijayakumar, Ganesh; Knaus, Robert; Sprague, Michael

    2017-11-01

    Understanding the impact of wind turbine wake dynamics on downstream turbines is particularly important for the design of efficient wind farms. Due to their tractable computational cost, hybrid RANS/LES models are an attractive framework for simulating separation flows such as the wake dynamics behind a wind turbine. High-order numerical methods can be computationally efficient and provide increased accuracy in simulating complex flows. In the context of LES, high-order numerical methods have shown some success in predictions of turbulent flows. However, the specifics of hybrid RANS-LES models, including the transition region between both modeling frameworks, pose unique challenges for high-order numerical methods. In this work, we study the effect of increasing the order of accuracy of the numerical scheme in simulations of canonical turbulent flows using RANS, LES, and hybrid RANS-LES models. We describe the interactions between filtering, model transition, and order of accuracy and their effect on turbulence quantities such as kinetic energy spectra, boundary layer evolution, and dissipation rate. This work was funded by the U.S. Department of Energy, Exascale Computing Project, under Contract No. DE-AC36-08-GO28308 with the National Renewable Energy Laboratory.

  4. Non-Indigenous Marine Species (NIMS) in Biofouling on RAN Vessels: Threat Analysis

    Science.gov (United States)

    2015-09-01

    Gulf of Mexico, and its range extends from the Caribbean to Brazil and Hawaii. It was first recorded in Australia on the German barque “Gorch Flock” in...4.2.2.10 Paracaprella pusilla (caprellid) P. pusilla is a tropical species native to Rio de Janeiro, Brazil and now common along the Atlantic coast...is found predominately in mangrove areas common to this region. This species was identified on HMAS Wewak (May 2004) on its return to HMAS Cairns

  5. Envisioning Spectrum Management in Virtualised C-RAN

    DEFF Research Database (Denmark)

    Al-Samman, Imad; Artuso, Matteo; Christiansen, Henrik Lehrmann

    2017-01-01

    Cloud Radio Access Network (C-RAN) has attracted a worldwide attention in both academia and industry. This network architecture re-forming has been considered as a potential solution to meet the increasing capacity demands for future mobile data traffic. In addition, Network Virtualisation...... is a promising technique for efficient resource utilisation. This paper proposes a customisable resource virtualisation algorithm for multi user data scheduling in a Long Term Evolution (LTE) C- RAN deployment. The algorithm is based on the hypervisor specific assignment of air resources allocation between...... the virtual operators (VOs) dynamically, based on either joint scheduling or per cell schemes. The objective is to improve the resource allocation mechanism based on traffic conditions and a database of pre-defined services priorities. Two distinctive scenarios are considered and evaluated against standard...

  6. Hybrid RANS/LES applied to complex terrain

    DEFF Research Database (Denmark)

    Bechmann, Andreas; Sørensen, Niels N.

    2011-01-01

    Large Eddy Simulation (LES) of the wind in complex terrain is limited by computational cost. The number of computational grid points required to resolve the near-ground turbulent structures (eddies) are very high. The traditional solution to the problem has been to apply a wall function...... aspect ratio in the RANS layer and thereby resolve the mean near-wall velocity profile. The method is applicable to complex terrain and the benefits of traditional LES are kept intact. Using the hybrid method, simulations of the wind over a natural complex terrain near Wellington in New Zealand...... that accounts for the whole near-wall region. Recently, a hybrid method was proposed in which the eddies close to the ground were modelled in a Reynolds-averaged sense (RANS) and the eddies above this region were simulated using LES. The advantage of the approach is the ability to use shallow cells of high...

  7. RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.

    Directory of Open Access Journals (Sweden)

    Azamat Aslanukov

    2006-10-01

    Full Text Available The Ran-binding protein 2 (RanBP2 is a large multimodular and pleiotropic protein. Several molecular partners with distinct functions interacting specifically with selective modules of RanBP2 have been identified. Yet, the significance of these interactions with RanBP2 and the genetic and physiological role(s of RanBP2 in a whole-animal model remain elusive. Here, we report the identification of two novel partners of RanBP2 and a novel physiological role of RanBP2 in a mouse model. RanBP2 associates in vitro and in vivo and colocalizes with the mitochondrial metallochaperone, Cox11, and the pacemaker of glycolysis, hexokinase type I (HKI via its leucine-rich domain. The leucine-rich domain of RanBP2 also exhibits strong chaperone activity toward intermediate and mature folding species of Cox11 supporting a chaperone role of RanBP2 in the cytosol during Cox11 biogenesis. Cox11 partially colocalizes with HKI, thus supporting additional and distinct roles in cell function. Cox11 is a strong inhibitor of HKI, and RanBP2 suppresses the inhibitory activity of Cox11 over HKI. To probe the physiological role of RanBP2 and its role in HKI function, a mouse model harboring a genetically disrupted RanBP2 locus was generated. RanBP2(-/- are embryonically lethal, and haploinsufficiency of RanBP2 in an inbred strain causes a pronounced decrease of HKI and ATP levels selectively in the central nervous system. Inbred RanBP2(+/- mice also exhibit deficits in growth rates and glucose catabolism without impairment of glucose uptake and gluconeogenesis. These phenotypes are accompanied by a decrease in the electrophysiological responses of photosensory and postreceptoral neurons. Hence, RanBP2 and its partners emerge as critical modulators of neuronal HKI, glucose catabolism, energy homeostasis, and targets for metabolic, aging disorders and allied neuropathies.

  8. RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.

    Science.gov (United States)

    Aslanukov, Azamat; Bhowmick, Reshma; Guruju, Mallikarjuna; Oswald, John; Raz, Dorit; Bush, Ronald A; Sieving, Paul A; Lu, Xinrong; Bock, Cheryl B; Ferreira, Paulo A

    2006-10-01

    The Ran-binding protein 2 (RanBP2) is a large multimodular and pleiotropic protein. Several molecular partners with distinct functions interacting specifically with selective modules of RanBP2 have been identified. Yet, the significance of these interactions with RanBP2 and the genetic and physiological role(s) of RanBP2 in a whole-animal model remain elusive. Here, we report the identification of two novel partners of RanBP2 and a novel physiological role of RanBP2 in a mouse model. RanBP2 associates in vitro and in vivo and colocalizes with the mitochondrial metallochaperone, Cox11, and the pacemaker of glycolysis, hexokinase type I (HKI) via its leucine-rich domain. The leucine-rich domain of RanBP2 also exhibits strong chaperone activity toward intermediate and mature folding species of Cox11 supporting a chaperone role of RanBP2 in the cytosol during Cox11 biogenesis. Cox11 partially colocalizes with HKI, thus supporting additional and distinct roles in cell function. Cox11 is a strong inhibitor of HKI, and RanBP2 suppresses the inhibitory activity of Cox11 over HKI. To probe the physiological role of RanBP2 and its role in HKI function, a mouse model harboring a genetically disrupted RanBP2 locus was generated. RanBP2(-/-) are embryonically lethal, and haploinsufficiency of RanBP2 in an inbred strain causes a pronounced decrease of HKI and ATP levels selectively in the central nervous system. Inbred RanBP2(+/-) mice also exhibit deficits in growth rates and glucose catabolism without impairment of glucose uptake and gluconeogenesis. These phenotypes are accompanied by a decrease in the electrophysiological responses of photosensory and postreceptoral neurons. Hence, RanBP2 and its partners emerge as critical modulators of neuronal HKI, glucose catabolism, energy homeostasis, and targets for metabolic, aging disorders and allied neuropathies.

  9. AVHRR GAC SST Reanalysis Version 1 (RAN1

    Directory of Open Access Journals (Sweden)

    Alexander Ignatov

    2016-04-01

    Full Text Available In response to its users’ needs, the National Oceanic and Atmospheric Administration (NOAA initiated reanalysis (RAN of the Advanced Very High Resolution Radiometer (AVHRR Global Area Coverage (GAC; 4 km sea surface temperature (SST data employing its Advanced Clear Sky Processor for Oceans (ACSPO retrieval system. Initially, AVHRR/3 data from five NOAA and two Metop satellites from 2002 to 2015 have been reprocessed. The derived SSTs have been matched up with two reference SSTs—the quality controlled in situ SSTs from the NOAA in situ Quality Monitor (iQuam and the Canadian Meteorological Centre (CMC L4 SST analysis—and analyzed in the NOAA SST Quality Monitor (SQUAM online system. The corresponding clear-sky ocean brightness temperatures (BT in AVHRR bands 3b, 4 and 5 (centered at 3.7, 11, and 12 µm, respectively have been compared with the Community Radiative Transfer Model simulations in another NOAA online system, Monitoring of Infrared Clear-sky Radiances over Ocean for SST (MICROS. For some AVHRRs, the time series of “AVHRR minus reference” SSTs and “observed minus model” BTs are unstable and inconsistent, with artifacts in the SSTs and BTs strongly correlated. In the official “Reanalysis version 1” (RAN1, data from only five platforms—two midmorning (NOAA-17 and Metop-A and three afternoon (NOAA-16, -18 and -19—were included during the most stable periods of their operations. The stability of the SST time series was further improved using variable regression SST coefficients, similarly to how it was done in the NOAA/NASA Pathfinder version 5.2 (PFV5.2 dataset. For data assimilation applications, especially those blending satellite and in situ SSTs, we recommend bias-correcting the RAN1 SSTs using the newly developed sensor-specific error statistics (SSES, which are reported in the product files. Relative performance of RAN1 and PFV5.2 SSTs is discussed. Work is underway to improve the calibration of AVHRR/3s and

  10. Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.

    Science.gov (United States)

    Patil, Hemangi; Cho, Kyoung-in; Lee, James; Yang, Yi; Orry, Andrew; Ferreira, Paulo A

    2013-03-27

    The pleckstrin homology (PH) domain is a versatile fold that mediates a variety of protein-protein and protein-phosphatidylinositol lipid interactions. The Ran-binding protein 2 (RanBP2) contains four interspersed Ran GTPase-binding domains (RBD(n = 1-4)) with close structural homology to the PH domain of Bruton's tyrosine kinase. The RBD2, kinesin-binding domain (KBD) and RBD3 comprise a tripartite domain (R2KR3) of RanBP2 that causes the unfolding, microtubule binding and biphasic activation of kinesin-1, a crucial anterograde motor of mitochondrial motility. However, the interplay between Ran GTPase and R2KR3 of RanBP2 in kinesin-1 activation and mitochondrial motility is elusive. We use structure-function, biochemical, kinetic and cell-based assays with time-lapse live-cell microscopy of over 260,000 mitochondrial-motility-related events to find mutually exclusive subdomains in RBD2 and RBD3 towards Ran GTPase binding, kinesin-1 activation and mitochondrial motility regulation. The RBD2 and RBD3 exhibit Ran-GTP-independent, subdomain and stereochemical-dependent discrimination on the biphasic kinetics of kinesin-1 activation or regulation of mitochondrial motility. Further, KBD alone and R2KR3 stimulate and suppress, respectively, multiple biophysical parameters of mitochondrial motility. The regulation of the bidirectional transport of mitochondria by either KBD or R2KR3 is highly coordinated, because their kinetic effects are accompanied always by changes in mitochondrial motile events of either transport polarity. These studies uncover novel roles in Ran GTPase-independent subdomains of RBD2 and RBD3, and KBD of RanBP2, that confer antagonizing and multi-modal mechanisms of kinesin-1 activation and regulation of mitochondrial motility. These findings open new venues towards the pharmacological harnessing of cooperative and competitive mechanisms regulating kinesins, RanBP2 or mitochondrial motility in disparate human disorders.

  11. Aggresome formation is regulated by RanBPM through an interaction with HDAC6

    Directory of Open Access Journals (Sweden)

    Louisa M. Salemi

    2014-05-01

    Full Text Available In conditions of proteasomal impairment, the build-up of damaged or misfolded proteins activates a cellular response leading to the recruitment of damaged proteins into perinuclear aggregates called aggresomes. Aggresome formation involves the retrograde transport of cargo proteins along the microtubule network and is dependent on the histone deacetylase HDAC6. Here we show that ionizing radiation (IR promotes Ran-Binding Protein M (RanBPM relocalization into discrete perinuclear foci where it co-localizes with aggresome components ubiquitin, dynein and HDAC6, suggesting that the RanBPM perinuclear clusters correspond to aggresomes. RanBPM was also recruited to aggresomes following treatment with the proteasome inhibitor MG132 and the DNA-damaging agent etoposide. Strikingly, aggresome formation by HDAC6 was markedly impaired in RanBPM shRNA cells, but was restored by re-expression of RanBPM. RanBPM was found to interact with HDAC6 and to inhibit its deacetylase activity. This interaction was abrogated by a RanBPM deletion of its LisH/CTLH domain, which also prevented aggresome formation, suggesting that RanBPM promotes aggresome formation through an association with HDAC6. Our results suggest that RanBPM regulates HDAC6 activity and is a central regulator of aggresome formation.

  12. Steady state RANS simulations of temperature fluctuations in single phase turbulent mixing

    International Nuclear Information System (INIS)

    Kickhofel, J.; Fokken, J.; Kapulla, R.; Prasser, H. M.

    2012-01-01

    Single phase turbulent mixing in nuclear power plant circuits where a strong temperature gradient is present is known to precipitate pipe failure due to thermal fatigue. Experiments in a square mixing channel offer the opportunity to study the phenomenon under simple and easily reproducible boundary conditions. Measurements of this kind have been performed extensively at the Paul Scherrer Inst. in Switzerland with a high density of instrumentation in the Generic Mixing Experiment (GEMIX). As a fundamental mixing phenomena study closely related to the thermal fatigue problem, the experimental results from GEMIX are valuable for the validation of CFD codes striving to accurately simulate both the temperature and velocity fields in single phase turbulent mixing. In the experiments two iso-kinetic streams meet at a shallow angle of 3 degrees and mix in a straight channel of square cross-section under various degrees of density, temperature, and viscosity stratification over a range of Reynolds numbers ranging from 5*10 3 to 1*10 5 . Conductivity measurements, using wire-mesh and wall sensors, as well as optical measurements, using particle image velocimetry, were conducted with high temporal and spatial resolutions (up to 2.5 kHz and 1 mm in the case of the wire mesh sensor) in the mixing zone, downstream of a splitter plate. The present paper communicates the results of RANS modeling of selected GEMIX tests. Steady-state CFD calculations using a RANS turbulence model represent an inexpensive method for analyzing large and complex components in commercial nuclear reactors, such as the downcomer and reactor pressure vessel heads. Crucial to real world applicability, however, is the ability to model turbulent heat fluctuations in the flow; the Turbulent Heat Flux Transport model developed by ANSYS CFX is capable, by implementation of a transport equation for turbulent heat fluxes, of readily modeling these values. Furthermore, the closure of the turbulent heat flux

  13. Maximum Throughput in a C-RAN Cluster with Limited Fronthaul Capacity

    OpenAIRE

    Duan , Jialong; Lagrange , Xavier; Guilloud , Frédéric

    2016-01-01

    International audience; Centralized/Cloud Radio Access Network (C-RAN) is a promising future mobile network architecture which can ease the cooperation between different cells to manage interference. However, the feasibility of C-RAN is limited by the large bit rate requirement in the fronthaul. This paper study the maximum throughput of different transmission strategies in a C-RAN cluster with transmission power constraints and fronthaul capacity constraints. Both transmission strategies wit...

  14. Power Optimization With BLER Constraint for Wireless Fronthauls in C-RAN

    OpenAIRE

    Vu, Thang Xuan; Nguyen, Thang Van; Quek, Tony Q.S.

    2016-01-01

    Cloud radio access network (C-RAN) is a novel architecture for future mobile networks to sustain the exponential traffic growth thanks to the exploitation of centralized processing. In C-RAN, one data processing center or baseband unit (BBU) communicates with users via distributed remote radio heads (RRHs), which are connected to the BBU via high capacity, low latency fronthaul links. In this letter, we study C-RAN with wireless fronthauls due to their flexibility in deployment and management...

  15. Knockdown of Ran GTPase expression inhibits the proliferation and migration of breast cancer cells.

    Science.gov (United States)

    Sheng, Chenyi; Qiu, Jian; Wang, Yingying; He, Zhixian; Wang, Hua; Wang, Qingqing; Huang, Yeqing; Zhu, Lianxin; Shi, Feng; Chen, Yingying; Xiong, Shiyao; Xu, Zhen; Ni, Qichao

    2018-05-03

    Breast cancer is the second leading cause of cancer‑associated mortality in women worldwide. Strong evidence has suggested that Ran, which is a small GTP binding protein involved in the transport of RNA and protein across the nucleus, may be a key cellular protein involved in the metastatic progression of cancer. The present study investigated Ran gene expression in breast cancer tissue samples obtained from 140 patients who had undergone surgical resection for breast cancer. Western blot analysis of Ran in breast cancer tissues and paired adjacent normal tissues showed that expression of Ran was significantly increased in breast cancer tissues. Immunohistochemistry analyses conducted on formalin‑fixed paraffin‑embedded breast cancer tissue sections revealed that Ran expression was associated with tumor histological grade, nerve invasion and metastasis, vascular metastasis and Ki‑67 expression (a marker of cell proliferation). Kaplan‑Meier survival analysis showed that increased Ran expression in patients with breast cancer was positively associated with a poor survival prognosis. Furthermore, in vitro experiments demonstrated that highly migratory MDA‑MB‑231 cancer cells treated with Ran‑si‑RNA (si‑Ran), which knocked down expression of Ran, exhibited decreased motility in trans‑well migration and wound healing assays. Cell cycle analysis of Ran knocked down MDA‑MB‑231 cells implicated Ran in cell cycle arrest and the inhibition of proliferation. Furthermore, a starvation and re‑feeding (CCK‑8) assay was performed, which indicated that Ran regulated breast cancer cell proliferation. Taken together, the results provide strong in vitro evidence of the involvement of Ran in the progression of breast cancer and suggest that it could have high potential as a therapeutic target and/or marker of disease.

  16. General and Specific Contributions of RAN to Reading and Arithmetic Fluency in First Graders: A Longitudinal Latent Variable Approach

    OpenAIRE

    Caroline Hornung; Romain Martin; Michel Fayol; Michel Fayol

    2017-01-01

    In the present study, we opted for a longitudinal design and examined rapid automatized naming (RAN) performance from two perspectives. In a first step, we examined the structure of RAN performance from a general cognitive perspective. We investigated whether rapid naming measures (e.g., digit RAN and color RAN) reflect a mainly domain-general factor or domain-specific factors. In a second step, we examined how the best fitting RAN model was related to reading and arithmetic outcomes, assesse...

  17. Encephalomyocarditis virus Leader protein hinge domain is responsible for interactions with Ran GTPase

    Energy Technology Data Exchange (ETDEWEB)

    Bacot-Davis, Valjean R., E-mail: bacotdavis@wisc.edu [Institute for Molecular Virology, University of Wisconsin-Madison, R.M. Bock Laboratories, 1525 Linden Dr. Madison, WI 53706 (United States); Palmenberg, Ann C., E-mail: acpalmen@wisc.edu [Institute for Molecular Virology, University of Wisconsin-Madison, R.M. Bock Laboratories, 1525 Linden Dr. Madison, WI 53706 (United States); Department of Biochemistry, University of Wisconsin-Madison, R.M. Bock Laboratories, 1525 Linden Dr. Madison, WI 53706 (United States)

    2013-08-15

    Encephalomyocarditis virus (EMCV), a Cardiovirus, initiates its polyprotein with a short 67 amino acid Leader (L) sequence. The protein acts as a unique pathogenicity factor, with anti-host activities which include the triggering of nuclear pore complex hyperphosphorylation and direct binding inhibition of the active cellular transport protein, Ran GTPase. Chemical modifications and protein mutagenesis now map the Ran binding domain to the L hinge-linker region, and in particular, to amino acids 35–40. Large deletions affecting this region were shown previously to diminish Ran binding. New point mutations, especially K35Q, D37A and W40A, preserve the intact L structure, abolish Ran binding and are deficient for nucleoporin (Nup) hyperphosphorylation. Ran itself morphs through multiple configurations, but reacts most effectively with L when in the GDP format, preferably with an empty nucleotide binding pocket. Therefore, L:Ran binding, mediated by the linker-hinge, is a required step in L-induced nuclear transport inhibition. - Highlights: • The hinge domain provides critical residues in Cardiovirus L:Ran complex formation. • Leader prefers to bind Ran in a nucleotide free, GDP-conformation. • L-induced Nup62 phosphorylation is reduced with Ran-deficient binding mutations.

  18. Essential role of the small GTPase Ran in postnatal pancreatic islet development.

    Directory of Open Access Journals (Sweden)

    Fang Xia

    Full Text Available The small GTPase Ran orchestrates pleiotropic cellular responses of nucleo-cytoplasmic shuttling, mitosis and subcellular trafficking, but whether deregulation of these pathways contributes to disease pathogenesis has remained elusive. Here, we generated transgenic mice expressing wild type (WT Ran, loss-of-function Ran T24N mutant or constitutively active Ran G19V mutant in pancreatic islet β cells under the control of the rat insulin promoter. Embryonic pancreas and islet development, including emergence of insulin(+ β cells, was indistinguishable in control or transgenic mice. However, by one month after birth, transgenic mice expressing any of the three Ran variants exhibited overt diabetes, with hyperglycemia, reduced insulin production, and nearly complete loss of islet number and islet mass, in vivo. Deregulated Ran signaling in transgenic mice, adenoviral over-expression of WT or mutant Ran in isolated islets, or short hairpin RNA (shRNA silencing of endogenous Ran in model insulinoma INS-1 cells, all resulted in decreased expression of the pancreatic and duodenal homeobox transcription factor, PDX-1, and reduced β cell proliferation, in vivo. These data demonstrate that a finely-tuned balance of Ran GTPase signaling is essential for postnatal pancreatic islet development and glucose homeostasis, in vivo.

  19. General and Specific Contributions of RAN to Reading and Arithmetic Fluency in First Graders: A Longitudinal Latent Variable Approach.

    Science.gov (United States)

    Hornung, Caroline; Martin, Romain; Fayol, Michel

    2017-01-01

    In the present study, we opted for a longitudinal design and examined rapid automatized naming (RAN) performance from two perspectives. In a first step, we examined the structure of RAN performance from a general cognitive perspective. We investigated whether rapid naming measures (e.g., digit RAN and color RAN) reflect a mainly domain-general factor or domain-specific factors. In a second step, we examined how the best fitting RAN model was related to reading and arithmetic outcomes, assessed several months later. Finally in a third step we took a clinical perspective and investigated specific contributions of RAN measures to reading and arithmetic outcomes. While RAN has emerged as a promising predictor of reading, the relationship between RAN and arithmetic has been less examined in the past. Hundred and twenty-two first graders completed seven RAN tasks, each comprising visually familiar stimuli such as digits, vowels, consonants, dice, finger-numeral configurations, objects, and colors. Four months later the same children completed a range of reading and arithmetic tasks. From a general descriptive perspective, structural equation modeling supports a one-dimensional RAN factor in 6- to -7-year-old children. However, from a clinical perspective, our findings emphasize the specific contributions of RANs. Interestingly, alphanumeric RANs (i.e., vowel RAN) were most promising when predicting reading skills and number-specific RANs (i.e., finger-numeral configuration RAN) were most promising when predicting arithmetic fluency. The implications for clinical and educational practices will be discussed.

  20. Containment vessel

    International Nuclear Information System (INIS)

    Zbirohowski-Koscia, K.F.; Roberts, A.C.

    1980-01-01

    A concrete containment vessel for nuclear reactors is disclosed that is spherical and that has prestressing tendons disposed in first, second and third sets, the tendons of each set being all substantially concentric and centred around a respective one of the three orthogonal axes of the sphere; the tendons of the first set being anchored at each end at a first anchor rib running around a circumference of the vessel, the tendons of the second set being anchored at each end at a second anchor rib running around a circumference of the sphere and disposed at 90 0 to the first rib, and the tendons of the third set being anchored some to the first rib and the remainder to the second rib. (author)

  1. Francis-99 turbine numerical flow simulation of steady state operation using RANS and RANS/LES turbulence model

    Science.gov (United States)

    Minakov, A.; Platonov, D.; Sentyabov, A.; Gavrilov, A.

    2017-01-01

    We performed numerical simulation of flow in a laboratory model of a Francis hydroturbine at three regimes, using two eddy-viscosity- (EVM) and a Reynolds stress (RSM) RANS models (realizable k-ɛ, k-ω SST, LRR) and detached-eddy-simulations (DES), as well as large-eddy simulations (LES). Comparison of calculation results with the experimental data was carried out. Unlike the linear EVMs, the RSM, DES, and LES reproduced well the mean velocity components, and pressure pulsations in the diffusor draft tube. Despite relatively coarse meshes and insufficient resolution of the near-wall region, LES, DES also reproduced well the intrinsic flow unsteadiness and the dominant flow structures and the associated pressure pulsations in the draft tube.

  2. Ran GTPase promotes cancer progression via Met receptor-mediated downstream signaling

    Science.gov (United States)

    Yuen, Hiu-Fung; Chan, Ka-Kui; Platt-Higgins, Angela; Dakir, El-Habib; Matchett, Kyle B.; Haggag, Yusuf Ahmed; Jithesh, Puthen V.; Habib, Tanwir; Faheem, Ahmed; Dean, Fennell A.; Morgan, Richard; Rudland, Philip S.; El-Tanani, Mohamed

    2016-01-01

    It has been shown previously that cancer cells with an activated oncogenic pathway, including Met activation, require Ran for growth and survival. Here, we show that knockdown of Ran leads to a reduction of Met receptor expression in several breast and lung cancer cell lines. This, in turn suppressed HGF expression and the Met-mediated activation of the Akt pathway, as well as cell adhesion, migration, and invasion. In a cell line model where Met amplification has previously been shown to contribute to gefitinib resistance, Ran knockdown sensitized cells to gefitinib-mediated inhibition of Akt and ERK1/2 phosphorylation and consequently reduced cell proliferation. We further demonstrate that Met reduction-mediated by knockdown of Ran, occurs at the post-transcriptional level, probably via a matrix metalloproteinase. Moreover, the level of immunoreactive Ran and Met are positively associated in human breast cancer specimens, suggesting that a high level of Ran may be a pre-requisite for Met overexpression. Interestingly, a high level of immunoreactive Ran dictates the prognostic significance of Met, indicating that the co-overexpression of Met and Ran may be associated with cancer progression and could be used in combination as a prognostic indicator. PMID:27716616

  3. Juristocracy in Brazil Ran Hirschl's Perspective About Judicial Empowerment

    Directory of Open Access Journals (Sweden)

    Claudia Maria Barbosa

    2015-12-01

    Full Text Available Within the classical view of separation of powers, the judiciary originally occupied the weaker position. What is observed today, however, is a displacement of power from representative institutions to the judiciary, erecting a new kind of political regime that the Canadian political scientist Ran Hirschl called juristocracy. This paper intends to discuss this movement basing on the idea of hegemonic preservation, presented by Hirschl in his work Towards Juristocracy whose central hypothesis is that the political, economic and social elites voluntarily transfer power to the judiciary, when threatened of losing their hegemony in the political sphere. In Brazil, the 1988 Constitution turned the Supreme Court into one of the world's most powerful courts, which works at the same time as constitutional court, court of appeals and criminal court, responsible for deciding the most fundamental issues for brazilian society. We present at first, the examples used by Hirschl to illustrate his thesis about the judicial empowerment through constitutionalization, analyzing the political and economic changes in recent history of Israel, Canada, New Zealand and South Africa, followed by an analysis of the phenomenon in Brazil. We conclude that it is not possible to determine, in principle, the occurrence of hegemonic preservation in Brazil, but that Hirschl's analysis that offers an answer that challenges the traditional view on the judicialization of politics, contributes to the discussion and analysis of the phenomenon in Brazil.

  4. Activation of Ran GTPase by a Legionella effector promotes microtubule polymerization, pathogen vacuole motility and infection.

    Directory of Open Access Journals (Sweden)

    Eva Rothmeier

    2013-09-01

    Full Text Available The causative agent of Legionnaires' disease, Legionella pneumophila, uses the Icm/Dot type IV secretion system (T4SS to form in phagocytes a distinct "Legionella-containing vacuole" (LCV, which intercepts endosomal and secretory vesicle trafficking. Proteomics revealed the presence of the small GTPase Ran and its effector RanBP1 on purified LCVs. Here we validate that Ran and RanBP1 localize to LCVs and promote intracellular growth of L. pneumophila. Moreover, the L. pneumophila protein LegG1, which contains putative RCC1 Ran guanine nucleotide exchange factor (GEF domains, accumulates on LCVs in an Icm/Dot-dependent manner. L. pneumophila wild-type bacteria, but not strains lacking LegG1 or a functional Icm/Dot T4SS, activate Ran on LCVs, while purified LegG1 produces active Ran(GTP in cell lysates. L. pneumophila lacking legG1 is compromised for intracellular growth in macrophages and amoebae, yet is as cytotoxic as the wild-type strain. A downstream effect of LegG1 is to stabilize microtubules, as revealed by conventional and stimulated emission depletion (STED fluorescence microscopy, subcellular fractionation and Western blot, or by microbial microinjection through the T3SS of a Yersinia strain lacking endogenous effectors. Real-time fluorescence imaging indicates that LCVs harboring wild-type L. pneumophila rapidly move along microtubules, while LCVs harboring ΔlegG1 mutant bacteria are stalled. Together, our results demonstrate that Ran activation and RanBP1 promote LCV formation, and the Icm/Dot substrate LegG1 functions as a bacterial Ran activator, which localizes to LCVs and promotes microtubule stabilization, LCV motility as well as intracellular replication of L. pneumophila.

  5. Activation of Ran GTPase by a Legionella Effector Promotes Microtubule Polymerization, Pathogen Vacuole Motility and Infection

    Science.gov (United States)

    Rothmeier, Eva; Pfaffinger, Gudrun; Hoffmann, Christine; Harrison, Christopher F.; Grabmayr, Heinrich; Repnik, Urska; Hannemann, Mandy; Wölke, Stefan; Bausch, Andreas; Griffiths, Gareth; Müller-Taubenberger, Annette; Itzen, Aymelt; Hilbi, Hubert

    2013-01-01

    The causative agent of Legionnaires' disease, Legionella pneumophila, uses the Icm/Dot type IV secretion system (T4SS) to form in phagocytes a distinct “Legionella-containing vacuole” (LCV), which intercepts endosomal and secretory vesicle trafficking. Proteomics revealed the presence of the small GTPase Ran and its effector RanBP1 on purified LCVs. Here we validate that Ran and RanBP1 localize to LCVs and promote intracellular growth of L. pneumophila. Moreover, the L. pneumophila protein LegG1, which contains putative RCC1 Ran guanine nucleotide exchange factor (GEF) domains, accumulates on LCVs in an Icm/Dot-dependent manner. L. pneumophila wild-type bacteria, but not strains lacking LegG1 or a functional Icm/Dot T4SS, activate Ran on LCVs, while purified LegG1 produces active Ran(GTP) in cell lysates. L. pneumophila lacking legG1 is compromised for intracellular growth in macrophages and amoebae, yet is as cytotoxic as the wild-type strain. A downstream effect of LegG1 is to stabilize microtubules, as revealed by conventional and stimulated emission depletion (STED) fluorescence microscopy, subcellular fractionation and Western blot, or by microbial microinjection through the T3SS of a Yersinia strain lacking endogenous effectors. Real-time fluorescence imaging indicates that LCVs harboring wild-type L. pneumophila rapidly move along microtubules, while LCVs harboring ΔlegG1 mutant bacteria are stalled. Together, our results demonstrate that Ran activation and RanBP1 promote LCV formation, and the Icm/Dot substrate LegG1 functions as a bacterial Ran activator, which localizes to LCVs and promotes microtubule stabilization, LCV motility as well as intracellular replication of L. pneumophila. PMID:24068924

  6. The RanGTP pathway: from nucleo-cytoplasmic transport to spindle assembly and beyond

    Directory of Open Access Journals (Sweden)

    Tommaso eCavazza

    2016-01-01

    Full Text Available The small GTPase Ran regulates the interaction of transport receptors with a number of cellular cargo proteins. The high affinity binding of the GTP-bound form of Ran to import receptors promotes cargo release, whereas its binding to export receptors stabilizes their interaction with the cargo. This basic mechanism linked to the asymmetric distribution of the two nucleotide-bound forms of Ran between the nucleus and the cytoplasm generates a switch like mechanism controlling nucleo-cytoplasmic transport. Since 1999, we have known that after nuclear envelope breakdown (NEBD Ran and the above transport receptors also provide a local control over the activity of factors driving spindle assembly and regulating other aspects of cell division. The identification and functional characterization of RanGTP mitotic targets is providing novel insights into mechanisms essential for cell division. Here we review our current knowledge on the RanGTP system and its regulation and we focus on the recent advances made through the characterization of its mitotic targets. We then briefly review the novel functions of the pathway that were recently described. Altogether, the RanGTP system has moonlighting functions exerting a spatial control over protein interactions that drive specific functions depending on the cellular context.

  7. Boundary layers affected by different pressure gradients investigated computationally by a zonal RANS-LES method

    International Nuclear Information System (INIS)

    Roidl, B.; Meinke, M.; Schröder, W.

    2014-01-01

    Highlights: • Reformulated synthetic turbulence generation method (RSTGM) is applied. • Zonal RANS-LES method is applied to boundary layers at pressure gradients. • Good agreement with the pure LES and other reference data is obtained. • The RSTGM is applicable to pressure gradient flows without modification. • RANS-to-LES boundary should be located where -1·10 6 6 is satisfied. -- Abstract: The reformulated synthetic turbulence generation (RSTG) method is used to compute by a fully coupled zonal RANS-LES approach turbulent non-zero-pressure gradient boundary layers. The quality of the RSTG method, which is based on the same shape functions and length scale distributions as in zero-pressure gradient flow, is discussed by comparing the zonal RANS-LES findings with pure LES, pure RANS, direct numerical simulation (DNS), and experimental data. For the favorable pressure gradient (FPG) simulation the RANS-to-LES transition occurs in the accelerated flow region and for the adverse pressure gradient (APG) case it is located in the decelerated flow region. The results of the time and spanwise averaged skin-friction distributions, velocity profiles, and Reynolds stress distributions of the zonal RANS-LES simulation show a satisfactory to good agreement with the pure LES, reference DNS, and experimental data. The quality of the findings shows that the rigorous formulation of the synthetic turbulence generation makes the RSTG method applicable without a priori knowledge of the flow properties but those determined by the RANS solution and without using additional control planes to regulate the shear stress budget to a wide range of Reynolds numbers and pressure gradients. The method is a promising approach to formulate embedded RANS-to-LES boundaries in flow regions where the Pohlhausen or acceleration parameter satisfies -1·10 -6 ⩽K⩽2·10 -6

  8. RANS Simulation of the Separated Flow over a Bump with Active Control

    Science.gov (United States)

    Iaccarino, Gianluca; Marongiu, Claudio; Catalano, Pietro; Amato, Marcello

    2003-01-01

    The objective of this paper is to investigate the accuracy of Reynolds-Averaged Navier- Stokes (RANS) techniques in predicting the effect of steady and unsteady flow control devices. This is part of a larger effort in applying numerical simulation tools to investigate of the performance of synthetic jets in high Reynolds number turbulent flows. RANS techniques have been successful in predicting isolated synthetic jets as reported by Kral et al. Nevertheless, due to the complex, and inherently unsteady nature of the interaction between the synthetic jet and the external boundary layer flow, it is not clear whether RANS models can represent the turbulence statistics correctly.

  9. Optimizing Cloud-RAN Deployments in Real-life Scenarios Using Microwave Radio

    DEFF Research Database (Denmark)

    Al-obaidi, Rami; Checko, Aleksandra; Holm, Henrik

    2015-01-01

    Cloud Radio Access Network (C-RAN) is a new architecture designed to be the candidate for enabling future mobile networks. However, it will be deployed only if it is economically viable. In this paper we investigate the technological options of C-RAN deployments. By using analytical methods we...... derive engineering guidelines for minimizing the CAPital EXpenditure (CAPEX) of C-RAN deployment. We show for which population density and span of BBU Pool coverage usage of Microwave Radio (MWR) links is viable. For larger scale deployment we recommend to divide the area into multiple BBU Pools....

  10. Long range echo classification for minehunting sonars

    NARCIS (Netherlands)

    Theije, P.A.M. de; Groen, J.; Sabel, J.C.

    2006-01-01

    This paper focesus on single-ping classification of sea mines, at a range of about 400 m, and combining a hull mounted sonar (HMS) and a propelled variable-depth sonar (PDVS). The deleoped classifier is trained and tested on a set of simulated realistic echoes of mines and non-mines. As the mines

  11. General and Specific Contributions of RAN to Reading and Arithmetic Fluency in First Graders: A Longitudinal Latent Variable Approach

    Directory of Open Access Journals (Sweden)

    Caroline Hornung

    2017-10-01

    Full Text Available In the present study, we opted for a longitudinal design and examined rapid automatized naming (RAN performance from two perspectives. In a first step, we examined the structure of RAN performance from a general cognitive perspective. We investigated whether rapid naming measures (e.g., digit RAN and color RAN reflect a mainly domain-general factor or domain-specific factors. In a second step, we examined how the best fitting RAN model was related to reading and arithmetic outcomes, assessed several months later. Finally in a third step we took a clinical perspective and investigated specific contributions of RAN measures to reading and arithmetic outcomes. While RAN has emerged as a promising predictor of reading, the relationship between RAN and arithmetic has been less examined in the past. Hundred and twenty-two first graders completed seven RAN tasks, each comprising visually familiar stimuli such as digits, vowels, consonants, dice, finger-numeral configurations, objects, and colors. Four months later the same children completed a range of reading and arithmetic tasks. From a general descriptive perspective, structural equation modeling supports a one-dimensional RAN factor in 6- to -7-year-old children. However, from a clinical perspective, our findings emphasize the specific contributions of RANs. Interestingly, alphanumeric RANs (i.e., vowel RAN were most promising when predicting reading skills and number-specific RANs (i.e., finger-numeral configuration RAN were most promising when predicting arithmetic fluency. The implications for clinical and educational practices will be discussed.

  12. Mesh Generation and Adaption for High Reynolds Number RANS Computations, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This proposal offers to provide NASA with an automatic mesh generator for the simulation of aerodynamic flows using Reynolds-Averages Navier-Stokes (RANS) models....

  13. Mesh Generation and Adaption for High Reynolds Number RANS Computations, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — This proposal offers to provide NASA with an automatic mesh generator for the simulation of aerodynamic flows using Reynolds-Averages Navier-Stokes (RANS) models....

  14. Energy Efficient Precoding C-RAN Downlink with Compression at Fronthaul

    OpenAIRE

    Nguyen, Kien-Giang; Vu, Quang-Doanh; Juntti, Markku; Tran, Le-Nam

    2017-01-01

    This paper considers a downlink transmission of cloud radio access network (C-RAN) in which precoded baseband signals at a common baseband unit are compressed before being forwarded to radio units (RUs) through limited fronthaul capacity links. We investigate the joint design of precoding, multivariate compression and RU-user selection which maximizes the energy efficiency of downlink C-RAN networks. The considered problem is inherently a rank-constrained mixed Boolean nonconvex program for w...

  15. Tuning a RANS k-e model for jet-in-crossflow simulations.

    Energy Technology Data Exchange (ETDEWEB)

    Lefantzi, Sophia; Ray, Jaideep; Arunajatesan, Srinivasan; DeChant, Lawrence Justin

    2013-09-01

    We develop a novel calibration approach to address the problem of predictive ke RANS simulations of jet-incrossflow. Our approach is based on the hypothesis that predictive ke parameters can be obtained by estimating them from a strongly vortical flow, specifically, flow over a square cylinder. In this study, we estimate three ke parameters, C%CE%BC, Ce2 and Ce1 by fitting 2D RANS simulations to experimental data. We use polynomial surrogates of 2D RANS for this purpose. We conduct an ensemble of 2D RANS runs using samples of (C%CE%BC;Ce2;Ce1) and regress Reynolds stresses to the samples using a simple polynomial. We then use this surrogate of the 2D RANS model to infer a joint distribution for the ke parameters by solving a Bayesian inverse problem, conditioned on the experimental data. The calibrated (C%CE%BC;Ce2;Ce1) distribution is used to seed an ensemble of 3D jet-in-crossflow simulations. We compare the ensemble's predictions of the flowfield, at two planes, to PIV measurements and estimate the predictive skill of the calibrated 3D RANS model. We also compare it against 3D RANS predictions using the nominal (uncalibrated) values of (C%CE%BC;Ce2;Ce1), and find that calibration delivers a significant improvement to the predictive skill of the 3D RANS model. We repeat the calibration using surrogate models based on kriging and find that the calibration, based on these more accurate models, is not much better that those obtained with simple polynomial surrogates. We discuss the reasons for this rather surprising outcome.

  16. Vessel Operator System

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Operator cards are required for any operator of a charter/party boat and or a commercial vessel (including carrier and processor vessels) issued a vessel permit from...

  17. An Enhanced OFDM Resource Allocation Algorithm in C-RAN Based 5G Public Safety Network

    Directory of Open Access Journals (Sweden)

    Lei Feng

    2016-01-01

    Full Text Available Public Safety Network (PSN is the network for critical communication when disaster occurs. As a key technology in 5G, Cloud-Radio Access Network (C-RAN can play an important role in PSN instead of LTE-based RAN. This paper firstly introduces C-RAN based PSN architecture and models the OFDM resource allocation problem in C-RAN based PSN as an integer quadratic programming, which allows the trade-off between expected bitrates and allocating fairness of PSN Service User (PSU. However, C-RAN based PSN needs to improve the efficiency of allocating algorithm because of a mass of PSU-RRH associations when disaster occurs. To deal with it, the resources allocating problem with integer variables is relaxed into one with continuous variables in the first step and an algorithm based on Generalized Bender’s Decomposition (GBD is proposed to solve it. Then we use Feasible Pump (FP method to get a feasible integer solution on the original OFDM resources allocation problem. The final experiments show the total throughput achieved by C-RAN based PSN is at most higher by 19.17% than the LTE-based one. And the average computational time of the proposed GBD and FP algorithm is at most lower than Barrier by 51.5% and GBD with no relaxation by 30.1%, respectively.

  18. Vortical structures and pressure pulsations in draft tube of a Francis-99 turbine at part load: RANS and hybrid RANS/LES analysis

    International Nuclear Information System (INIS)

    Gavrilov, A.A.; Sentyabov, A.V.; Dekterev, A.A.; Hanjalić, K.

    2017-01-01

    Highlights: • Simulations showed the formation of spiralling coherent vortices in the draft tube. • Both hybrid RANS-LES and Re-stress models reproduced well the measured fluctuations. • Re-stress model resolved the precessing vortex core and coherent spiralling vortices. - Abstract: Recognizing the limitations of the conventional linear-eddy-viscosity (LEVM) Reynolds-averaged Navier–Stokes (RANS) models to reproduce complex three-dimensional unsteady flows in hydraulic machinery, we performed a comparative assessment of a second-moment (Re-stress model, RSM) RANS closure and a hybrid RANS/LES method in capturing the flow and vortical structures in the draft tube of a Francis hydroturbine at off-design conditions. Considered is a case of part load (PL) at a flow rate of only 35% of the best efficiency point (BEP) characterised by multiple unsteady vortex systems. Despite some remaining uncertainties in generating the inflow conditions, both approaches reproduced reasonably well the measured mean velocity and the rms of its fluctuations, as well as the pressure spectrum with peaks detecting the precessing vortex core. In contrast to the common LEVMs, the Re-stress closure showed sufficient receptivity to intrinsic unsteadiness and reproduced well the overall flow and vortical patterns as well as the associated pressure pulsations in accord with the experiments. The hybrid RANS/LES method gave similar predictions as the RSM, but resolving a wider range of scales, which however, showed no significant effect on the dynamics of the dominant processing vortex core and the pressure pulsations.

  19. The Cellular Distribution of RanGAP1 Is Regulated by CRM1-Mediated Nuclear Export in Mammalian Cells.

    Directory of Open Access Journals (Sweden)

    Keith Cha

    Full Text Available The Ran GTPase activating protein RanGAP1 plays an essential role in nuclear transport by stimulating RanGTP hydrolysis in the cytoplasmic compartment. In mammalian cells, unmodified RanGAP1 is predominantly cytoplasmic, whereas modification by small ubiquitin-related modifier protein (SUMO targets RanGAP1 to the cytoplasmic filaments of nuclear pore complex (NPC. Although RanGAP1 contains nine putative nuclear export signals and a nuclear localization signal, little is known if RanGAP1 shuttles between the nuclear and cytoplasmic compartments and how its primary localization in the cytoplasm and at the NPC is regulated. Here we show that inhibition of CRM1-mediated nuclear export using RNAi-knockdown of CRM1 and inactivation of CRM1 by leptomycin B (LMB results in nuclear accumulation of RanGAP1. LMB treatment induced a more robust redistribution of RanGAP1 from the cytoplasm to the nucleoplasm compared to CRM1 RNAi and also uniquely triggered a decrease or loss of RanGAP1 localization at the NPC, suggesting that LMB treatment is more effective in inhibiting CRM1-mediated nuclear export of RanGAP1. Our time-course analysis of LMB treatment reveals that the NPC-associated RanGAP1 is much more slowly redistributed to the nucleoplasm than the cytoplasmic RanGAP1. Furthermore, LMB-induced nuclear accumulation of RanGAP1 is positively correlated with an increase in levels of SUMO-modified RanGAP1, suggesting that SUMOylation of RanGAP1 may mainly take place in the nucleoplasm. Lastly, we demonstrate that the nuclear localization signal at the C-terminus of RanGAP1 is required for its nuclear accumulation in cells treated with LMB. Taken together, our results elucidate that RanGAP1 is actively transported between the nuclear and cytoplasmic compartments, and that the cytoplasmic and NPC localization of RanGAP1 is dependent on CRM1-mediated nuclear export.

  20. Determination of Scaled Wind Turbine Rotor Characteristics from Three Dimensional RANS Calculations

    International Nuclear Information System (INIS)

    Burmester, S; Gueydon, S; Make, M

    2016-01-01

    Previous studies have shown the importance of 3D effects when calculating the performance characteristics of a scaled down turbine rotor [1-4]. In this paper the results of 3D RANS (Reynolds-Averaged Navier-Stokes) computations by Make and Vaz [1] are taken to calculate 2D lift and drag coefficients. These coefficients are assigned to FAST (Blade Element Momentum Theory (BEMT) tool from NREL) as input parameters. Then, the rotor characteristics (power and thrust coefficients) are calculated using BEMT. This coupling of RANS and BEMT was previously applied by other parties and is termed here the RANS-BEMT coupled approach. Here the approach is compared to measurements carried out in a wave basin at MARIN applying Froude scaled wind, and the direct 3D RANS computation. The data of both a model and full scale wind turbine are used for the validation and verification. The flow around a turbine blade at full scale has a more 2D character than the flow properties around a turbine blade at model scale (Make and Vaz [1]). Since BEMT assumes 2D flow behaviour, the results of the RANS-BEMT coupled approach agree better with the results of the CFD (Computational Fluid Dynamics) simulation at full- than at model-scale. (paper)

  1. Ran GTPase protein promotes human pancreatic cancer proliferation by deregulating the expression of Survivin and cell cycle proteins

    International Nuclear Information System (INIS)

    Deng, Lin; Lu, Yuanyuan; Zhao, Xiaodi; Sun, Yi; Shi, Yongquan; Fan, Hongwei; Liu, Changhao; Zhou, Jinfeng; Nie, Yongzhan; Wu, Kaichun; Fan, Daiming; Guo, Xuegang

    2013-01-01

    Highlights: •Overexpression of Ran in pancreatic cancer was correlated with histological grade. •Downregulation of Ran could induce cell apoptosis and inhibit cell proliferation. •The effects were mediated by cell cycle proteins, Survivin and cleaved Caspase-3. -- Abstract: Ran, a member of the Ras GTPase family, has important roles in nucleocytoplasmic transport. Herein, we detected Ran expression in pancreatic cancer and explored its potential role on tumour progression. Overexpressed Ran in pancreatic cancer tissues was found highly correlated with the histological grade. Downregulation of Ran led to significant suppression of cell proliferation, cell cycle arrest at the G1/S phase and induction of apoptosis. In vivo studies also validated that result. Further studies revealed that those effects were at least partly mediated by the downregulation of Cyclin A, Cyclin D1, Cyclin E, CDK2, CDK4, phospho-Rb and Survivin proteins and up regulation of cleaved Caspase-3

  2. Does ability to establish sound-symbol pairings mediate the RAN reading relationship?

    DEFF Research Database (Denmark)

    Poulsen, Mads; Juul, Holger; Elbro, Carsten

    for animals in a paired associate learning task. These animals were then used in a rapid naming task. Results Preliminary results show that reading correlated with the amount of training required for learning the animal names (r=-.19, p=.06). RAN speed with the same animals did not correlate with reading......Performance on tests to rapidly name letters and digits has been shown to correlate with reading. One possible reason is that these tests probe the ability to learn and automatise symbol-sound associations. However, most studies have not controlled for the amount of experience with the RAN......-items, so it is unclear whether it is the experience or the ability to take advantage of the experience that is responsible for the correlation between RAN and reading. Paired associate learning tasks have been shown to differentiate dyslexics from controls, and to correlate with reading in unselected...

  3. RCC1 regulates inner centromeric composition in a Ran-independent fashion.

    Science.gov (United States)

    Zhang, Michael Shaofei; Furuta, Maiko; Arnaoutov, Alexei; Dasso, Mary

    2018-01-01

    RCC1 associates to chromatin dynamically within mitosis and catalyzes Ran-GTP production. Exogenous RCC1 disrupts kinetochore structure in Xenopus egg extracts (XEEs), but the molecular basis of this disruption remains unknown. We have investigated this question, utilizing replicated chromosomes that possess paired sister kinetochores. We find that exogenous RCC1 evicts a specific subset of inner KT proteins including Shugoshin-1 (Sgo1) and the chromosome passenger complex (CPC). We generated RCC1 mutants that separate its enzymatic activity and chromatin binding. Strikingly, Sgo1 and CPC eviction depended only on RCC1's chromatin affinity but not its capacity to produce Ran-GTP. RCC1 similarly released Sgo1 and CPC from synthetic kinetochores assembled on CENP-A nucleosome arrays. Together, our findings indicate RCC1 regulates kinetochores at the metaphase-anaphase transition through Ran-GTP-independent displacement of Sgo1 and CPC.

  4. Hybrid RANS/LES method for wind flow over complex terrain

    DEFF Research Database (Denmark)

    Bechmann, Andreas; Sørensen, Niels N.

    2010-01-01

    for flows at high Reynolds numbers. To reduce the computational cost of traditional LES, a hybrid method is proposed in which the near-wall eddies are modelled in a Reynolds-averaged sense. Close to walls, the flow is treated with the Reynolds-averaged Navier-Stokes (RANS) equations (unsteady RANS...... rough walls. Previous attempts of combining RANS and LES has resulted in unphysical transition regions between the two layers, but the present work improves this region by using a stochastic backscatter model. To demonstrate the ability of the proposed hybrid method, simulations are presented for wind...... the turbulent kinetic energy, whereas the new method captures the high turbulence levels well but underestimates the mean velocity. The presented results are for a relative mild configuration of complex terrain, but the proposed method can also be used for highly complex terrain where the benefits of the new...

  5. Performance assessment of the RANS turbulence models in nuclear fuel rod bundles

    International Nuclear Information System (INIS)

    In, Wang Kee; Chun, Tae Hyun; Oh, Dong Seok; Shin, Chang Hwan

    2005-02-01

    The three experiments for turbulent flow in a rod bundle geometry were simulated in this CFD analysis using various RANS models. The CFD predictions were compared with the experimental and DNS results. The RANS models used here are the nonlinear quadratic/cubic κ-ε models and the second-order closure models (SSG, LRR, RSM-ω). The anisotropic models predicted the secondary flow and showed a significantly improved agreement with the measurements from the standard κ-ε model. In particular, the SSG model resulted in the best performance showing the closest agreement with the experimental results. However, the RANS models could not predict the very high anisotropy observed in a rod bundle with a small pitch-to-diameter ratio

  6. Assessment of unsteady-RANS approach against steady-RANS approach for predicting twin impinging jets in a cross-flow

    Directory of Open Access Journals (Sweden)

    Zhiyin Yang

    2014-12-01

    Full Text Available A complex flow field is created when a vertical/short take-off and landing aircraft is operating near ground. One major concern for this kind of aircraft in ground effect is the possibility of ingestion of hot gases from the jet engine exhausts back into the engine, known as hot gas ingestion, which can increase the intake air temperature and also reduce the oxygen content in the intake air, potentially leading to compressor stall, low combustion efficiency and causing a dramatic loss of lift. This flow field can be represented by the configuration of twin impinging jets in a cross-flow. Accurate prediction of this complicated flow field under the Reynolds averaged Navier–Stokes (RANS approach (current practise in industry is a great challenge as previous studies suggest that some important flow features cannot be captured by the Steady-RANS (SRANS approach even with a second-order Reynolds stress model (RSM. This paper presents a numerical study of this flow using the Unsteady-RANS (URANS approach with a RSM and the results clearly indicate that the URANS approach is superior than the SRANS approach but still the predictions of Reynolds stress are not accurate enough.

  7. Multiple shell pressure vessel

    International Nuclear Information System (INIS)

    Wedellsborg, B.W.

    1988-01-01

    A method is described of fabricating a pressure vessel comprising the steps of: attaching a first inner pressure vessel having means defining inlet and outlet openings to a top flange, placing a second inner pressure vessel, having means defining inlet and outlet opening, concentric with and spaced about the first inner pressure vessel and attaching the second inner pressure vessel to the top flange, placing an outer pressure vessel, having inlet and outlet openings, concentric with and spaced apart about the second inner pressure vessel and attaching the outer pressure vessel to the top flange, attaching a generally cylindrical inner inlet conduit and a generally cylindrical inner outlet conduit respectively to the inlet and outlet openings in the first inner pressure vessel, attaching a generally cylindrical outer inlet conduit and a generally cylindrical outer outlet conduit respectively to the inlet and outlet opening in the second inner pressure vessel, heating the assembled pressure vessel to a temperature above the melting point of a material selected from the group, lead, tin, antimony, bismuth, potassium, sodium, boron and mixtures thereof, filling the space between the first inner pressure vessel and the second inner pressure vessel with material selected from the group, filling the space between the second inner pressure vessel and the outer pressure vessel with material selected from the group, and pressurizing the material filling the spaces between the pressure vessels to a predetermined pressure, the step comprising: pressurizing the spaces to a pressure whereby the wall of the first inner pressure vessel is maintained in compression during steady state operation of the pressure vessel

  8. Optimal Assignment of Cells in C-RAN Deployments with Multiple BBU Pools

    DEFF Research Database (Denmark)

    Holm, Henrik; Checko, Aleksandra; Al-obaidi, Rami

    2015-01-01

    Cloud Radio Access Network (C-RAN) is receiving increasing attention not only within the research community but also from operators and standardization bodies. However, even a good technology will be deployed only if it is economically viable. In our previous work, for larger scale deployment we...... recommend to divide the area into multiple BBU Pools. In this paper we show how to optimally assign cells to different BBU Pools in such a scenario. By using Integer Linear Programming (ILP) method we derive engineering guidelines for minimizing the CAPital EXpenditure (CAPEX) of C-RAN deployment....

  9. RANS-based simulation of turbulent wave boundary layer and sheet-flow sediment transport processes

    DEFF Research Database (Denmark)

    Fuhrman, David R.; Schløer, Signe; Sterner, Johanna

    2013-01-01

    A numerical model coupling the horizontal component of the incompressible Reynolds-averaged Navier–Stokes (RANS) equationswith two-equation k−ω turbulence closure is presented and used to simulate a variety of turbulent wave boundary layer processes. The hydrodynamic model is additionally coupled...... with bed and suspended load descriptions, the latter based on an unsteady turbulent-diffusion equation, for simulation of sheet-flow sediment transport processes. In addition to standard features common within such RANS-based approaches, the present model includes: (1) hindered settling velocities at high...

  10. Probabilistic retinal vessel segmentation

    Science.gov (United States)

    Wu, Chang-Hua; Agam, Gady

    2007-03-01

    Optic fundus assessment is widely used for diagnosing vascular and non-vascular pathology. Inspection of the retinal vasculature may reveal hypertension, diabetes, arteriosclerosis, cardiovascular disease and stroke. Due to various imaging conditions retinal images may be degraded. Consequently, the enhancement of such images and vessels in them is an important task with direct clinical applications. We propose a novel technique for vessel enhancement in retinal images that is capable of enhancing vessel junctions in addition to linear vessel segments. This is an extension of vessel filters we have previously developed for vessel enhancement in thoracic CT scans. The proposed approach is based on probabilistic models which can discern vessels and junctions. Evaluation shows the proposed filter is better than several known techniques and is comparable to the state of the art when evaluated on a standard dataset. A ridge-based vessel tracking process is applied on the enhanced image to demonstrate the effectiveness of the enhancement filter.

  11. Improvement to reactor vessel

    International Nuclear Information System (INIS)

    1974-01-01

    The vessel described includes a prestressed concrete vessel containing a chamber and a removable cover closing this chamber. The cover is in concrete and is kept in its closed position by main and auxiliary retainers, comprising fittings integral with the concrete of the vessel. The auxiliary retainers pass through the concrete of the cover. This improvement may be applied to BWR, PWR and LMFBR type reactor vessel [fr

  12. ALICE HMPID Radiator Vessel

    CERN Document Server

    2003-01-01

    View of the radiator vessels of the ALICE/HMPID mounted on the support frame. Each HMPID module is equipped with 3 indipendent radiator vessels made out of neoceram and fused silica (quartz) windows glued together. The spacers inside the vessel are needed to stand the hydrostatic pressure. http://alice-hmpid.web.cern.ch/alice-hmpid

  13. Assessment of RANS and LES Turbulence Modeling for Buoyancy-Aided/Opposed Forced and Mixed Convection

    Science.gov (United States)

    Clifford, Corey; Kimber, Mark

    2017-11-01

    Over the last 30 years, an industry-wide shift within the nuclear community has led to increased utilization of computational fluid dynamics (CFD) to supplement nuclear reactor safety analyses. One such area that is of particular interest to the nuclear community, specifically to those performing loss-of-flow accident (LOFA) analyses for next-generation very-high temperature reactors (VHTR), is the capacity of current computational models to predict heat transfer across a wide range of buoyancy conditions. In the present investigation, a critical evaluation of Reynolds-averaged Navier-Stokes (RANS) and large-eddy simulation (LES) turbulence modeling techniques is conducted based on CFD validation data collected from the Rotatable Buoyancy Tunnel (RoBuT) at Utah State University. Four different experimental flow conditions are investigated: (1) buoyancy-aided forced convection; (2) buoyancy-opposed forced convection; (3) buoyancy-aided mixed convection; (4) buoyancy-opposed mixed convection. Overall, good agreement is found for both forced convection-dominated scenarios, but an overly-diffusive prediction of the normal Reynolds stress is observed for the RANS-based turbulence models. Low-Reynolds number RANS models perform adequately for mixed convection, while higher-order RANS approaches underestimate the influence of buoyancy on the production of turbulence.

  14. Eulerian–Lagrangian RANS Model Simulations of the NIST Turbulent Methanol Spray Flame

    NARCIS (Netherlands)

    Zhu, Shanglong; Roekaerts, Dirk; Pozarlik, Artur Krzysztof; van der Meer, Theodorus H.

    2015-01-01

    A methanol spray flame in a combustion chamber of the NIST was simulated using an Eulerian–Lagrangian RANS model. Experimental data and previous numerical investigations by other researchers on this flame were analyzed to develop methods for more comprehensive model validation. The inlet boundary

  15. Numerical prediction of a bulb turbine performance hill chart through RANS simulations

    International Nuclear Information System (INIS)

    Guénette, V; Houde, S; Ciocan, G D; Deschênes, C; Dumas, G; Huang, J

    2012-01-01

    Within the framework of an international research consortium on low-head hydraulic turbine flow dynamics, the predictive behavior of Reynolds Averaged Navier-Stokes (RANS) simulations of the efficiency (η) hill chart of a bulb turbine is investigated. The paper presents the impacts of the blade tip gap and the hub gaps on performance predictions.

  16. Mel-18 interacts with RanGAP1 and inhibits its sumoylation.

    Science.gov (United States)

    Zhang, Jie; Sarge, Kevin D

    2008-10-17

    Our previous results showed that the polycomb protein mel-18 binds to a protein called HSF2 and inhibits HSF2 sumoylation, thereby functioning as an anti-SUMO E3 factor. This study also suggested that mel-18 regulates the sumoylation of other cellular proteins, but the identities of these other proteins were unknown. Here we show that mel-18 interacts with the RanGAP1 protein and inhibits its sumoylation, and that these activities do not require the RING domain of mel-18. The results also show that RanGAP1 sumoylation is decreased during mitosis, and that this is associated with increased interaction between RanGAP1 and mel-18 during this stage of the cell cycle. Intriguingly, this regulatory relationship is the opposite of that found for mel-18 and HSF2, in which the interaction between these two proteins decreases during mitosis, resulting in elevated HSF2 sumoylation. The results of this study strengthen the conclusion that mel-18 functions as an anti-SUMO E3 factor, and extend its targets to include regulation of the sumoylation of the important cellular protein RanGAP1.

  17. Inadequacy representation of flamelet-based RANS model for turbulent non-premixed flame

    Science.gov (United States)

    Lee, Myoungkyu; Oliver, Todd; Moser, Robert

    2017-11-01

    Stochastic representations for model inadequacy in RANS-based models of non-premixed jet flames are developed and explored. Flamelet-based RANS models are attractive for engineering applications relative to higher-fidelity methods because of their low computational costs. However, the various assumptions inherent in such models introduce errors that can significantly affect the accuracy of computed quantities of interest. In this work, we develop an approach to represent the model inadequacy of the flamelet-based RANS model. In particular, we pose a physics-based, stochastic PDE for the triple correlation of the mixture fraction. This additional uncertain state variable is then used to construct perturbations of the PDF for the instantaneous mixture fraction, which is used to obtain an uncertain perturbation of the flame temperature. A hydrogen-air non-premixed jet flame is used to demonstrate the representation of the inadequacy of the flamelet-based RANS model. This work was supported by DARPA-EQUiPS(Enabling Quantification of Uncertainty in Physical Systems) program.

  18. OTN Transport of Baseband Radio Serial Protocols in C-RAN Architecture for Mobile Network Applications

    DEFF Research Database (Denmark)

    Checko, Aleksandra; Kardaras, Georgios; Lanzani, Christian Fabio Alessandro

    This white paper presents a proof of concept implementation of digital baseband radio data transport over Optical Transport Network (OTN) compliant to 3GPP Long Term Evolution – Advanced (LTE-A) standard enabling Cloud Radio Access Network (C-RAN) architecture. The transport between the baseband ...

  19. Computing the flow past Vortex Generators : Comparison between RANS Simulations and Experiments

    NARCIS (Netherlands)

    Manolesos, M.; Sorensen, NN; Troldborg, N.; Florentie, L.; Papadakis, G; Voutsinas, S.

    2016-01-01

    The flow around a wind turbine airfoil equipped with Vortex Generators (VGs) is examined. Predictions from three different Reynolds Averaged Navier Stokes (RANS) solvers with two different turbulence models and two different VG modelling approaches are compared between them and with experimental

  20. Zonal PANS: evaluation of different treatments of the RANS-LES interface

    Science.gov (United States)

    Davidson, L.

    2016-03-01

    The partially Reynolds-averaged Navier-Stokes (PANS) model can be used to simulate turbulent flows either as RANS, large eddy simulation (LES) or DNS. Its main parameter is fk whose physical meaning is the ratio of the modelled to the total turbulent kinetic energy. In RANS fk = 1, in DNS fk = 0 and in LES fk takes values between 0 and 1. Three different ways of prescribing fk are evaluated for decaying grid turbulence and fully developed channel flow: fk = 0.4, fk = k3/2tot/ɛ and, from its definition, fk = k/ktot where ktot is the sum of the modelled, k, and resolved, kres, turbulent kinetic energy. It is found that the fk = 0.4 gives the best results. In Girimaji and Wallin, a method was proposed to include the effect of the gradient of fk. This approach is used at RANS- LES interface in the present study. Four different interface models are evaluated in fully developed channel flow and embedded LES of channel flow: in both cases, PANS is used as a zonal model with fk = 1 in the unsteady RANS (URANS) region and fk = 0.4 in the LES region. In fully developed channel flow, the RANS- LES interface is parallel to the wall (horizontal) and in embedded LES, it is parallel to the inlet (vertical). The importance of the location of the horizontal interface in fully developed channel flow is also investigated. It is found that the location - and the choice of the treatment at the interface - may be critical at low Reynolds number or if the interface is placed too close to the wall. The reason is that the modelled turbulent shear stress at the interface is large and hence the relative strength of the resolved turbulence is small. In RANS, the turbulent viscosity - and consequently also the modelled Reynolds shear stress - is only weakly dependent on Reynolds number. It is found in the present work that it also applies in the URANS region.

  1. Pressure vessel design manual

    CERN Document Server

    Moss, Dennis R

    2013-01-01

    Pressure vessels are closed containers designed to hold gases or liquids at a pressure substantially different from the ambient pressure. They have a variety of applications in industry, including in oil refineries, nuclear reactors, vehicle airbrake reservoirs, and more. The pressure differential with such vessels is dangerous, and due to the risk of accident and fatality around their use, the design, manufacture, operation and inspection of pressure vessels is regulated by engineering authorities and guided by legal codes and standards. Pressure Vessel Design Manual is a solutions-focused guide to the many problems and technical challenges involved in the design of pressure vessels to match stringent standards and codes. It brings together otherwise scattered information and explanations into one easy-to-use resource to minimize research and take readers from problem to solution in the most direct manner possible. * Covers almost all problems that a working pressure vessel designer can expect to face, with ...

  2. Tumor Blood Vessel Dynamics

    Science.gov (United States)

    Munn, Lance

    2009-11-01

    ``Normalization'' of tumor blood vessels has shown promise to improve the efficacy of chemotherapeutics. In theory, anti-angiogenic drugs targeting endothelial VEGF signaling can improve vessel network structure and function, enhancing the transport of subsequent cytotoxic drugs to cancer cells. In practice, the effects are unpredictable, with varying levels of success. The predominant effects of anti-VEGF therapies are decreased vessel leakiness (hydraulic conductivity), decreased vessel diameters and pruning of the immature vessel network. It is thought that each of these can influence perfusion of the vessel network, inducing flow in regions that were previously sluggish or stagnant. Unfortunately, when anti-VEGF therapies affect vessel structure and function, the changes are dynamic and overlapping in time, and it has been difficult to identify a consistent and predictable normalization ``window'' during which perfusion and subsequent drug delivery is optimal. This is largely due to the non-linearity in the system, and the inability to distinguish the effects of decreased vessel leakiness from those due to network structural changes in clinical trials or animal studies. We have developed a mathematical model to calculate blood flow in complex tumor networks imaged by two-photon microscopy. The model incorporates the necessary and sufficient components for addressing the problem of normalization of tumor vasculature: i) lattice-Boltzmann calculations of the full flow field within the vasculature and within the tissue, ii) diffusion and convection of soluble species such as oxygen or drugs within vessels and the tissue domain, iii) distinct and spatially-resolved vessel hydraulic conductivities and permeabilities for each species, iv) erythrocyte particles advecting in the flow and delivering oxygen with real oxygen release kinetics, v) shear stress-mediated vascular remodeling. This model, guided by multi-parameter intravital imaging of tumor vessel structure

  3. Maury Journals - German Vessels

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — German vessels observations, after the 1853 Brussels Conference that set International Maritime Standards, modeled after Maury Marine Standard Observations.

  4. Evaluating C-RAN Fronthaul Functional Splits in Terms of Network Level Energy and Cost Savings

    DEFF Research Database (Denmark)

    Checko, Aleksandra; Popovska Avramova, Andrijana; Berger, Michael Stübert

    2016-01-01

    The placement of the complete baseband processing in a centralized pool results in high data rate requirement and inflexibility of the fronthaul network, which challenges the energy and cost effectiveness of the cloud radio access network (C-RAN). Recently, redesign of the C-RAN through functional...... split in the baseband processing chain has been proposed to overcome these challenges. This paper evaluates, by mathematical and simulation methods, different splits with respect to network level energy and cost efficiency having in the mind the expected quality of service.The proposed mathematical...... model quantifies the multiplexing gains and the trade-offs between centralization and decentralization concerning the cost of the pool, fronthaul network capacity and resource utilization. The event-based simulation captures the influence of the traffic load dynamics and traffic type variation...

  5. Hybrid RANS/LES method for high Reynolds numbers, applied to atmospheric flow over complex terrain

    DEFF Research Database (Denmark)

    Bechmann, Andreas; Sørensen, Niels N.; Johansen, Jeppe

    2007-01-01

      The use of Large-Eddy Simulation (LES) to predict wall-bounded flows has presently been limited to low Reynolds number flows. Since the number of computational grid points required to resolve the near-wall turbulent structures increase rapidly with Reynolds number, LES has been unattainable...... for flows at high Reynolds numbers. To reduce the computational cost of traditional LES a hybrid method is proposed in which the near-wall eddies are modelled in a Reynolds-averaged sense. Close to walls the flow is treated with the RANS-equations and this layer act as wall model for the outer flow handled...... by LES. The wellknown high Reynolds number two-equation k - ǫ turbulence model is used in the RANS layer and the model automatically switches to a two-equation k - ǫ subgrid-scale stress model in the LES region. The approach can be used for flow over rough walls. To demonstrate the ability...

  6. Simulation of wing-body junction flows with hybrid RANS/LES methods

    International Nuclear Information System (INIS)

    Fu Song; Xiao Zhixiang; Chen Haixin; Zhang Yufei; Huang Jingbo

    2007-01-01

    In this paper, flows past two wing-body junctions, the Rood at zero angle of attack and NASA TN D-712 at 12.5 o angle of attack, are investigated with two Reynolds-Averaged Navier-Stokes (RANS) and large eddy simulation (LES) hybrid methods. One is detached eddy simulation (DES) and the other is delayed-DES, both are based on a weakly nonlinear two-equation k-ω model. While the RANS method can predict the mean flow behaviours reasonably accurately, its performance for the turbulent kinetic energy and shear stress, as compared with available experimental data, is not satisfactory. DES, through introducing a length scale in the dissipation terms of the turbulent kinetic energy equation, delivers flow separation, a vortex or the onset of vortex breakdown too early. DDES, with its delayed effect, shows a great improvement in flow structures and turbulence characteristics, and agrees well with measurements

  7. Hybrid RANS/LES of flow and heat transfer in round impinging jets

    International Nuclear Information System (INIS)

    Kubacki, Slawomir; Dick, Erik

    2011-01-01

    Fluid flow and convective heat transfer predictions are presented of round impinging jets for several combinations of nozzle-plate distances H/D = 2, 6 and 13.5 (where D is the nozzle diameter) and Reynolds numbers Re = 5000, 23,000 and 70,000 with the newest version of the k-ω model of and three hybrid RANS/LES models. In the RANS mode of the hybrid RANS/LES models, the k-ω model is recovered. Three formulations are considered to activate the LES mode. The first model is similar to the hybrid models of and . The turbulent length scale is replaced by the grid size in the destruction term of the k-equation and in the definition of the RANS eddy viscosity. As grid size, a maximum measure of the hexahedral grid cell is used. The second model has the same k-equation, but the eddy viscosity is the minimum of the k-ω eddy viscosity and the Smagorinsky eddy viscosity, following a proposal by . The Smagorinsky eddy viscosity is formed with the cube root of the cell volume. The third model has, again, the same k-equation, but has an eddy viscosity which is an intermediate between the eddy viscosities of the first and second models. This is reached by using the cube root of the cell volume in the eddy viscosity formula of the first model. The simulation results are compared with experimental data for the high Reynolds number cases Re = 23,000 and Re = 70,000 and LES data for the low-Reynolds number case Re = 5000. The Reynolds numbers are defined with the nozzle diameter and the bulk velocity at nozzle outlet. At low nozzle-plate distance (the impingement plate is in the core of the jet), turbulent kinetic energy is overpredicted by RANS in the stagnation flow region. This leads to overprediction of the heat transfer rate along the impingement plate in the impact zone. At high nozzle-plate distance (the impingement plate is in the mixed-out region of the jet), the turbulence mixing is underpredicted by RANS in the shear layer of the jet which gives a too high length of

  8. A comparative study of manhole hydraulics using stereoscopic PIV and different RANS models.

    Science.gov (United States)

    Beg, Md Nazmul Azim; Carvalho, Rita F; Tait, Simon; Brevis, Wernher; Rubinato, Matteo; Schellart, Alma; Leandro, Jorge

    2017-04-01

    Flows in manholes are complex and may include swirling and recirculation flow with significant turbulence and vorticity. However, how these complex 3D flow patterns could generate different energy losses and so affect flow quantity in the wider sewer network is unknown. In this work, 2D3C stereo Particle Image Velocimetry measurements are made in a surcharged scaled circular manhole. A computational fluid dynamics (CFD) model in OpenFOAM ® with four different Reynolds Averaged Navier Stokes (RANS) turbulence model is constructed using a volume of fluid model, to represent flows in this manhole. Velocity profiles and pressure distributions from the models are compared with the experimental data in view of finding the best modelling approach. It was found among four different RANS models that the re-normalization group (RNG) k-ɛ and k-ω shear stress transport (SST) gave a better approximation for velocity and pressure.

  9. ARA24/Ran enhances the androgen-dependent NH2- and COOH-terminal interaction of the androgen receptor

    International Nuclear Information System (INIS)

    Harada, Naoki; Ohmori, Yuji; Yamaji, Ryoichi; Higashimura, Yasuki; Okamoto, Kazuki; Isohashi, Fumihide; Nakano, Yoshihisa; Inui, Hiroshi

    2008-01-01

    The androgen receptor (AR) acts as an androgen-dependent transcription factor controlling the development of prostate tissue. Upon binding to androgen, AR undergoes a dynamic structural change leading to interaction between the NH 2 - and COOH-terminal regions of AR (N-C interaction). ARA24/Ran, which is a small GTPase, functions as an AR coactivator. Here, we report that ARA24/Ran enhances the N-C interaction of AR. The constitutively GTP- or GDP-bound form of ARA24/Ran repressed the AR N-C interaction. ARA24/Ran did not enhance the transcriptional activities of AR mutants that disrupt the N-C interaction. ARA24/Ran formed an endogenous protein complex with nuclear AR, but not cytoplasmic AR. Unlike SRC-1 with the positive activity for AR N-C interaction, ARA24/Ran did not enhance the transcriptional activity of the COOH-terminal domain-deleted AR mutant that is constitutively localized in the nucleus. These data demonstrate that ARA24/Ran increases AR transactivation by enhancing the AR N-C interaction in the nucleus

  10. On the use of (U)RANS and LES approaches for turbulent incompressible single phase flows in nuclear engineering applications

    Energy Technology Data Exchange (ETDEWEB)

    Benhamadouche, Sofiane, E-mail: sofiane.benhamadouche@edf.fr

    2017-02-15

    Highlights: • The paper deals with the use of (U)RANS and LES in nuclear engineering applications. • It gives some ideas and guidelines to run high quality computations. • Some perspectives are drawn concerning the development of (U)RANS and LES approaches in the future. - Abstract: The present paper gives some ideas and guidelines in order to run high quality (U)RANS or LES computations. The paper starts with (U)RANS approaches, advocating the use of Reynolds Stress Models for complex flows and recommending further work on modeling of turbulent heat fluxes, which remains today too basic in industry. The superiority of wall-resolved models vs. wall-modeled in RANS is recalled and the use of adaptive wall treatment is suggested. The concept of Unsteady RANS is finally questioned. Then, important issues around LES are raised. The mesh refinement criteria are recalled for wall-resolved LES and the use of wall models addressed. The production of DNS and wall-resolved LES calculations for flow understanding and RANS validation is encouraged.

  11. OTN Transport of Baseband Radio Serial Protocols in C-RAN Architecture for Mobile Network Applications

    OpenAIRE

    Checko, Aleksandra; Kardaras, Georgios; Lanzani, Christian Fabio Alessandro; Temple, Dan; Mathiasen, Carsten; Pedersen, Lars A.; Klaps, Bert

    2014-01-01

    This white paper presents a proof of concept implementation of digital baseband radio data transport over Optical Transport Network (OTN) compliant to 3GPP Long Term Evolution – Advanced (LTE-A) standard enabling Cloud Radio Access Network (C-RAN) architecture. The transport between the baseband module and a remote radio module is compliant to Common Public Radio Interface (CPRI) and to the OBSAI reference point 3 - 01 (RP3-01) interface protocols, respectively. The purpose is to demonstrate ...

  12. Statistical Multiplexing of Computations in C-RAN with Tradeoffs in Latency and Energy

    OpenAIRE

    Kalør, Anders E.; Agurto, Mauricio I.; Pratas, Nuno K.; Nielsen, Jimmy J.; Popovski, Petar

    2017-01-01

    In the Cloud Radio Access Network (C-RAN) architecture, the baseband signals from multiple remote radio heads are processed in a centralized baseband unit (BBU) pool. This architecture allows network operators to adapt the BBU’scomputational resources to the aggregate access load experienced at the BBU, which can change in every air-interface access frame. The degree of savings that can be achieved by adapting the resources is a tradeoff between savings, adaptation frequency, and increased qu...

  13. Computing the flow past Vortex Generators: Comparison between RANS Simulations and Experiments

    DEFF Research Database (Denmark)

    Manolesos, M.; Sørensen, Niels N.; Troldborg, Niels

    2016-01-01

    The flow around a wind turbine airfoil equipped with Vortex Generators (VGs) is examined. Predictions from three different Reynolds Averaged Navier Stokes (RANS) solvers with two different turbulence models and two different VG modelling approaches are compared between them and with experimental ...... data. The best results are obtained with the more expensive fully resolved VG approach. The cost efficient BAY model can also provide acceptable results, if grid related numerical diffusion is minimized and only force coefficient polars are considered....

  14. Benchmarking LES with wall-functions and RANS for fatigue problems in thermal–hydraulics systems

    Energy Technology Data Exchange (ETDEWEB)

    Tunstall, R., E-mail: ryan.tunstall@manchester.ac.uk [School of MACE, The University of Manchester, Manchester M13 9PL (United Kingdom); Laurence, D.; Prosser, R. [School of MACE, The University of Manchester, Manchester M13 9PL (United Kingdom); Skillen, A. [Scientific Computing Department, STFC Daresbury Laboratory, Warrington WA4 4AD (United Kingdom)

    2016-11-15

    Highlights: • We benchmark LES with blended wall-functions and low-Re RANS for a pipe bend and T-Junction. • Blended wall-laws allow the first cell from the wall to be placed anywhere in the boundary layer. • In both cases LES predictions improve as the first cell wall spacing is reduced. • Near-wall temperature fluctuations in the T-Junction are overpredicted by wall-modelled LES. • The EBRSM outperforms other RANS models for the pipe bend. - Abstract: In assessing whether nuclear plant components such as T-Junctions are likely to suffer thermal fatigue problems in service, CFD techniques need to provide accurate predictions for wall temperature fluctuations. Though it has been established that this is within the capabilities of wall-resolved LES, its high computational cost has prevented widespread usage in industry. In the present paper the suitability of LES with blended wall-functions, that allow the first cell to be placed in any part of the boundary layer, is assessed. Numerical results for the flows through a 90° pipe bend and a T-Junction are compared against experimental data. Both test cases contain areas where equilibrium laws are violated in practice. It is shown that reducing the first cell wall spacing improves agreement with experimental data by limiting the extent from the wall in which the solution is constrained to an equilibrium law. The LES with wall-function approach consistently overpredicts the near-wall temperature fluctuations in the T-Junction, suggesting that it can be considered as a conservative approach. We also benchmark a range of low-Re RANS models. EBRSM predictions for the 90° pipe bend are in significantly better agreement with experimental data than those from the other models. There are discrepancies from all RANS models in the case of the T-Junction.

  15. Propeller Analysis Using RANS/BEM Coupling Accounting for Blade Blockage

    Science.gov (United States)

    2015-07-04

    are taken into account. It has been implemented using the open source RANS solver OpenFOAM ® and the BEM propeller code PROCAL developed by...Each of these is available in the OpenFOAM mesh data structures. 2.2 Implementation in OpenFOAM In the SIMPLE algorithm as implemented in OpenFOAM ...in OpenFOAM , the source term + must be added to the momentum equations and the source term − to the pressure equation. To apply

  16. The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes.

    Directory of Open Access Journals (Sweden)

    Takashi Shibano

    Full Text Available The inner nuclear membrane (INM protein Nemp1/TMEM194A has previously been suggested to be involved in eye development in Xenopus, and contains two evolutionarily conserved sequences in the transmembrane domains (TMs and the C-terminal region, named region A and region B, respectively. To elucidate the molecular nature of Nemp1, we analyzed its interacting proteins through those conserved regions. First, we found that Nemp1 interacts with itself and lamin through the TMs and region A, respectively. Colocalization of Nemp1 and lamin at the INM suggests that the interaction with lamin participates in the INM localization of Nemp1. Secondly, through yeast two-hybrid screening using region B as bait, we identified the small GTPase Ran as a probable Nemp1-binding partner. GST pulldown and co-immunoprecipitation assays using region B and Ran mutants revealed that region B binds directly to the GTP-bound Ran through its effector domain. Immunostaining experiments using transfected COS-7 cells revealed that full-length Nemp1 recruits Ran near the nuclear envelope, suggesting a role for Nemp1 in the accumulation of RanGTP at the nuclear periphery. At the neurula-to-tailbud stages of Xenopus embryos, nemp1 expression overlapped with ran in several regions including the eye vesicles. Co-knockdown using antisense morpholino oligos for nemp1 and ran caused reduction of cell densities and severe eye defects more strongly than either single knockdown alone, suggesting their functional interaction. Finally we show that Arabidopsis thaliana Nemp1-orthologous proteins interact with A. thaliana Ran, suggesting their evolutionally conserved physical and functional interactions possibly in basic cellular functions including nuclear transportation. Taken together, we conclude that Nemp1 represents a new type of RanGTP-binding protein.

  17. Data-free and data-driven spectral perturbations for RANS UQ

    Science.gov (United States)

    Edeling, Wouter; Mishra, Aashwin; Iaccarino, Gianluca

    2017-11-01

    Despite recent developments in high-fidelity turbulent flow simulations, RANS modeling is still vastly used by industry, due to its inherent low cost. Since accuracy is a concern in RANS modeling, model-form UQ is an essential tool for assessing the impacts of this uncertainty on quantities of interest. Applying the spectral decomposition to the modeled Reynolds-Stress Tensor (RST) allows for the introduction of decoupled perturbations into the baseline intensity (kinetic energy), shape (eigenvalues), and orientation (eigenvectors). This constitutes a natural methodology to evaluate the model form uncertainty associated to different aspects of RST modeling. In a predictive setting, one frequently encounters an absence of any relevant reference data. To make data-free predictions with quantified uncertainty we employ physical bounds to a-priori define maximum spectral perturbations. When propagated, these perturbations yield intervals of engineering utility. High-fidelity data opens up the possibility of inferring a distribution of uncertainty, by means of various data-driven machine-learning techniques. We will demonstrate our framework on a number of flow problems where RANS models are prone to failure. This research was partially supported by the Defense Advanced Research Projects Agency under the Enabling Quantification of Uncertainty in Physical Systems (EQUiPS) project (technical monitor: Dr Fariba Fahroo), and the DOE PSAAP-II program.

  18. Present state and future of CFD based on three-dimensional RANS analysis

    International Nuclear Information System (INIS)

    Kim, Kwang Yong

    2004-01-01

    Computational Fluid Dynamics (CFD) based on Navier-Stokes equations has been developed rapidly for several decades with the developments of high speed computers and numerical algorithms, and presently is regarded as an essential analysis tool in the engineering applications containing fluid flow and convective heat transfer. It is known that for turbulent flow the Navier-Stokes equations can be calculated precisely by Direct Numerical Simulation (DNS). However, DNS needs huge computing time even for simple low-Reynolds number flows, and thus is not practical. Large Eddy Simulation (LES) can be an alternative. But, LES also needs considerable computing time for the analysis of engineering flows, and have some problem in the methods. Therefore, the analysis methods using Reynolds-averaged Navier-stokes equations (RANS) and turbulence closure models are still regarded as the major techniques for the analysis of turbulent flows in spite of the inaccuracy of the prediction. In this presentation, the present state and the prospect of CFD based on three-dimensional RANS analysis are introduced for physical models and numerical algorithms with the engineering examples. Especially, for the analysis of two-phase flows in nuclear reactor, the recently developed techniques are also introduced. And, the presentation includes the methods of design optimization using RANS analysis and numerical optimization techniques with variety of the applications

  19. Nuclear size is sensitive to NTF2 protein levels in a manner dependent on Ran binding

    Science.gov (United States)

    Vuković, Lidija D.; Jevtić, Predrag; Zhang, Zhaojie; Stohr, Bradley A.; Levy, Daniel L.

    2016-01-01

    ABSTRACT Altered nuclear size is associated with many cancers, and determining whether cancer-associated changes in nuclear size contribute to carcinogenesis necessitates an understanding of mechanisms of nuclear size regulation. Although nuclear import rates generally positively correlate with nuclear size, NTF2 levels negatively affect nuclear size, despite the role of NTF2 (also known as NUTF2) in nuclear recycling of the import factor Ran. We show that binding of Ran to NTF2 is required for NTF2 to inhibit nuclear expansion and import of large cargo molecules in Xenopus laevis egg and embryo extracts, consistent with our observation that NTF2 reduces the diameter of the nuclear pore complex (NPC) in a Ran-binding-dependent manner. Furthermore, we demonstrate that ectopic NTF2 expression in Xenopus embryos and mammalian tissue culture cells alters nuclear size. Finally, we show that increases in nuclear size during melanoma progression correlate with reduced NTF2 expression, and increasing NTF2 levels in melanoma cells is sufficient to reduce nuclear size. These results show a conserved capacity for NTF2 to impact on nuclear size, and we propose that NTF2 might be a new cancer biomarker. PMID:26823604

  20. Assessment of brain activation regulation in first graders via RAN / RAS test

    Directory of Open Access Journals (Sweden)

    Tatiana V. Akhutina

    2015-03-01

    Full Text Available RAN / RAS test (Rapid Automatized Naming / Rapid Alternating Stimulus has been used successfully used by many psychologists, primarily to predict the risk of dyslexia, as it includes a language component and requires good visual-verbal connections. However, The research demonstrates that the low speed of naming is an effective indicator of neurocognitive problems of information processing as a whole (learning difficulties in general, not just reading difficulties. This can be explained in two ways: disturbance of executive mental control and the difficulties of automatization: the difficulties of the transition from a controlled energy-consuming assignment to a less energy-consuming one. The second interpretation describes the problems of energy resources of cognitive functioning. It is similar to weak maintenance of cortical structures activation. However, using the test mentioned herewith for assessing functions of activation regulation has not been described previously. In terms of the Luria’s three functional units of the brain theory the RAN / RAS test can be considered as sensitive to the weakness of the first unit, whose function is to maintain the activity of cortical structures. So the aim of the research is to prove the possibility of assessing the activation regulation using the RAN / RAS test. This issue is relevant because neuropsychological tools for determining the weakness of Unit I functions are not quite sufficient, while the problem of “energetic” unit ranks first in the frequency of occurrence in children with learning disabilities.

  1. A RANS knock model to predict the statistical occurrence of engine knock

    International Nuclear Information System (INIS)

    D'Adamo, Alessandro; Breda, Sebastiano; Fontanesi, Stefano; Irimescu, Adrian; Merola, Simona Silvia; Tornatore, Cinzia

    2017-01-01

    Highlights: • Development of a new RANS model for SI engine knock probability. • Turbulence-derived transport equations for variances of mixture fraction and enthalpy. • Gasoline autoignition delay times calculated from detailed chemical kinetics. • Knock probability validated against experiments on optically accessible GDI unit. • PDF-based knock model accounting for the random nature of SI engine knock in RANS simulations. - Abstract: In the recent past engine knock emerged as one of the main limiting aspects for the achievement of higher efficiency targets in modern spark-ignition (SI) engines. To attain these requirements, engine operating points must be moved as close as possible to the onset of abnormal combustions, although the turbulent nature of flow field and SI combustion leads to possibly ample fluctuations between consecutive engine cycles. This forces engine designers to distance the target condition from its theoretical optimum in order to prevent abnormal combustion, which can potentially damage engine components because of few individual heavy-knocking cycles. A statistically based RANS knock model is presented in this study, whose aim is the prediction not only of the ensemble average knock occurrence, poorly meaningful in such a stochastic event, but also of a knock probability. The model is based on look-up tables of autoignition times from detailed chemistry, coupled with transport equations for the variance of mixture fraction and enthalpy. The transported perturbations around the ensemble average value are based on variable gradients and on a local turbulent time scale. A multi-variate cell-based Gaussian-PDF model is proposed for the unburnt mixture, resulting in a statistical distribution for the in-cell reaction rate. An average knock precursor and its variance are independently calculated and transported; this results in the prediction of an earliest knock probability preceding the ensemble average knock onset, as confirmed by

  2. Reactor vessel sealing plug

    International Nuclear Information System (INIS)

    Dooley, R.A.

    1986-01-01

    This invention relates to an apparatus and method for sealing the cold leg nozzles of a nuclear reactor pressure vessel from a remote location during maintenance and inspection of associated steam generators and pumps while the pressure vessel and refueling canal are filled with water. The apparatus includes a sealing plug for mechanically sealing the cold leg nozzle from the inside of a reactor pressure vessel. The sealing plugs include a primary and a secondary O-ring. An installation tool is suspended within the reactor vessel and carries the sealing plug. The tool telescopes to insert the sealing plug within the cold leg nozzle, and to subsequently remove the plug. Hydraulic means are used to activate the sealing plug, and support means serve to suspend the installation tool within the reactor vessel during installation and removal of the sealing plug

  3. Containment vessel drain system

    Science.gov (United States)

    Harris, Scott G.

    2018-01-30

    A system for draining a containment vessel may include a drain inlet located in a lower portion of the containment vessel. The containment vessel may be at least partially filled with a liquid, and the drain inlet may be located below a surface of the liquid. The system may further comprise an inlet located in an upper portion of the containment vessel. The inlet may be configured to insert pressurized gas into the containment vessel to form a pressurized region above the surface of the liquid, and the pressurized region may operate to apply a surface pressure that forces the liquid into the drain inlet. Additionally, a fluid separation device may be operatively connected to the drain inlet. The fluid separation device may be configured to separate the liquid from the pressurized gas that enters the drain inlet after the surface of the liquid falls below the drain inlet.

  4. NCSX Vacuum Vessel Fabrication

    International Nuclear Information System (INIS)

    Viola ME; Brown T; Heitzenroeder P; Malinowski F; Reiersen W; Sutton L; Goranson P; Nelson B; Cole M; Manuel M; McCorkle D.

    2005-01-01

    The National Compact Stellarator Experiment (NCSX) is being constructed at the Princeton Plasma Physics Laboratory (PPPL) in conjunction with the Oak Ridge National Laboratory (ORNL). The goal of this experiment is to develop a device which has the steady state properties of a traditional stellarator along with the high performance characteristics of a tokamak. A key element of this device is its highly shaped Inconel 625 vacuum vessel. This paper describes the manufacturing of the vessel. The vessel is being fabricated by Major Tool and Machine, Inc. (MTM) in three identical 120 o vessel segments, corresponding to the three NCSX field periods, in order to accommodate assembly of the device. The port extensions are welded on, leak checked, cut off within 1-inch of the vessel surface at MTM and then reattached at PPPL, to accommodate assembly of the close-fitting modular coils that surround the vessel. The 120 o vessel segments are formed by welding two 60 o segments together. Each 60 o segment is fabricated by welding ten press-formed panels together over a collapsible welding fixture which is needed to precisely position the panels. The vessel is joined at assembly by welding via custom machined 8-inch (20.3 cm) wide spacer ''spool pieces''. The vessel must have a total leak rate less than 5 X 10 -6 t-l/s, magnetic permeability less than 1.02(micro), and its contours must be within 0.188-inch (4.76 mm). It is scheduled for completion in January 2006

  5. The nucleoporin MEL-28 promotes RanGTP-dependent γ-tubulin recruitment and microtubule nucleation in mitotic spindle formation.

    Science.gov (United States)

    Yokoyama, Hideki; Koch, Birgit; Walczak, Rudolf; Ciray-Duygu, Fulya; González-Sánchez, Juan Carlos; Devos, Damien P; Mattaj, Iain W; Gruss, Oliver J

    2014-01-01

    The GTP-bound form of the Ran GTPase (RanGTP), produced around chromosomes, drives nuclear envelope and nuclear pore complex (NPC) re-assembly after mitosis. The nucleoporin MEL-28/ELYS binds chromatin in a RanGTP-regulated manner and acts to seed NPC assembly. Here we show that, upon mitotic NPC disassembly, MEL-28 dissociates from chromatin and re-localizes to spindle microtubules and kinetochores. MEL-28 directly binds microtubules in a RanGTP-regulated way via its C-terminal chromatin-binding domain. Using Xenopus egg extracts, we demonstrate that MEL-28 is essential for RanGTP-dependent microtubule nucleation and spindle assembly, independent of its function in NPC assembly. Specifically, MEL-28 interacts with the γ-tubulin ring complex and recruits it to microtubule nucleation sites. Our data identify MEL-28 as a RanGTP target that functions throughout the cell cycle. Its cell cycle-dependent binding to chromatin or microtubules discriminates MEL-28 functions in interphase and mitosis, and ensures that spindle assembly occurs only after NPC breakdown.

  6. Radioactive waste processing vessel

    International Nuclear Information System (INIS)

    Hayashi, Masaru; Suzuki, Osamu; Ishizaki, Kanjiro.

    1987-01-01

    Purpose: To obtain a vessel of a reduced weight and with no external leaching of radioactive materials. Constitution: The vessel main body is constituted, for example, with light weight concretes or foamed concretes, particularly, foamed concretes containing fine closed bubbles in the inside. Then, layers having dense texture made of synthetic resin such as polystylene, vinylchloride resin, etc. or metal plate such as stainless plate are integrally disposed to the inner surface of the vessel main body. The cover member also has the same structure. (Sekiya, K.)

  7. Tempest in a vessel

    International Nuclear Information System (INIS)

    Barre, Bertrand

    2015-01-01

    As the ASN made some statements about anomalies of carbon content in the EPR vessel bottom and top, the author recalls and comments some technical issues to better understand the information published on this topic. He notably addresses the role of the vessel, briefly indicates its operating conditions, shape and structure, and mechanical components for the top, its material and mechanical properties, and test samples used to assess mechanical properties. He also comments the phenomenon of radio-induced embrittlement, the vessel manufacturing process, and evokes the applicable regulations. He quotes and comments statements made by the ASN and Areva which evoke further assessments of the concerned components

  8. Ivan Rančić: A forgotten painter of flowers and landscapes

    Directory of Open Access Journals (Sweden)

    Marković Kamenko M.

    2014-01-01

    Full Text Available Ivan Rančić was born in the Kraljevo village, in eastern Serbia to a family of farmers on 19th, February, 1906. Very little data about him has been preserved, therefore, this paper is an attempt to make a reconstruction of his life and work. He attended primary school in his birth place, lower secondary school he finished in Knjazevac and Military Academy in Belgrade. After completing the National Academy in 1934, he was sent to Zagreb where he got his first post. He lived there with his wife and his son until the capitulation of the country in 1941. A few months after the collapse of the country, he was arrested and sent to Ljubljana and three months later to a concentration camp in Austria. He spent about fifteen months in that camp in during which time he intensively studied painting. He fled from the camp to Switzerland and stayed there until his death in 1987. According to some letters he sent to his wife in Nis, some of his paintings he created during his time in the camp, ne took to Switzerland where he eventually sold them. He did the toughest jobs there in order to survive and painted extensively. After World War II he graduated from the School of Fine Arts in Lausanne. Later on he had two exhibitions at the New Gallery of Modern Art. Ivan Rančić came a long way from an unknown beginner to a respected prominent artist. He left behind about 350 works, many of which he sold during his life, mainly landscapes and still life in oil, watercolor and pastel. He was neither concerned about styles and trends nor did he believe in the old and the new. If he came to a certain specific manner of painting, it is because at one point it was imposed on him as the only proper way of expression. The analysis of Rančić's paintings leads to the conclusion that his creation had gone through four phases. The first one (started in the concentration camp in Austria during which he painted still lifes without full sketches, previous studies, and the use

  9. RANS Analyses of Turbofan Nozzles with Internal Wedge Deflectors for Noise Reduction

    Science.gov (United States)

    DeBonis, James R.

    2009-01-01

    Computational fluid dynamics (CFD) was used to evaluate the flow field and thrust performance of a promising concept for reducing the noise at take-off of dual-stream turbofan nozzles. The concept, offset stream technology, reduces the jet noise observed on the ground by diverting (offsetting) a portion of the fan flow below the core flow, thickening and lengthening this layer between the high-velocity core flow and the ground observers. In this study a wedge placed in the internal fan stream is used as the diverter. Wind, a Reynolds averaged Navier-Stokes (RANS) code, was used to analyze the flow field of the exhaust plume and to calculate nozzle performance. Results showed that the wedge diverts all of the fan flow to the lower side of the nozzle, and the turbulent kinetic energy on the observer side of the nozzle is reduced. This reduction in turbulent kinetic energy should correspond to a reduction in noise. However, because all of the fan flow is diverted, the upper portion of the core flow is exposed to the freestream, and the turbulent kinetic energy on the upper side of the nozzle is increased, creating an unintended noise source. The blockage due to the wedge reduces the fan mass flow proportional to its blockage, and the overall thrust is consequently reduced. The CFD predictions are in very good agreement with experimental flow field data, demonstrating that RANS CFD can accurately predict the velocity and turbulent kinetic energy fields. While this initial design of a large scale wedge nozzle did not meet noise reduction or thrust goals, this study identified areas for improvement and demonstrated that RANS CFD can be used to improve the concept.

  10. İRAN VE REJİM İSTİKRARI

    Directory of Open Access Journals (Sweden)

    Özgür ÜŞENMEZ

    2015-07-01

    Full Text Available ÖZ: Bu çalışma, İran rejiminin son yıllarda Orta Doğu'yu sarsan isyanlar ve istikrarsızlıklara-Batı'daki beklentilerin aksine- geçmişten, özellikle 1979'daki devrimden miras kalan sosyal yapı ve politikaların etkisiyle direnebildiğini iddia ediyor. Tunus ve Mısır'daki halk isyanları, temel aktör olan alt sınıflar ve onların neo-liberal ekonomik politikalara muhalefetiyle yayılırken, İran’da devrim sonrası gelişen sosyal devlet mekanizması hala halk ile rejimin tamamen birbirine yabancılaşmasını önlemekte. Ancak son yıllarda ortaya çıkan yeni gerilimler ve İran'ın uyguladığı ekonomi politikaları rejimin krizini derinleştirebilir. Bu nedenledir ki Orta Doğu'yu ve özelde İran'ı anlamak için hegemonik blokların tarihsel değişimini inceleyen ucu açık bir analiz elzemdir. ABSTRACT: This article argues that contrary to the expectations of the Western World, Iranian regime successfully resisted the revolutionary tides of the Arab Spring. Most important determinant of this process for Iran was the legacy of the 1979 revolution and it's associated structures that relatively protects the most vulnerable parts of the population against the wide spread neo-liberal economic policies in the Middle East. So with that feature Iran differs from the Tunisian and the Egyptian examples. In order to understand these features further this essay adapts a historical analysis of changes in hegemonic blocs in Iran since 1979.

  11. RANS modeling for particle transport and deposition in turbulent duct flows: Near wall model uncertainties

    International Nuclear Information System (INIS)

    Jayaraju, S.T.; Sathiah, P.; Roelofs, F.; Dehbi, A.

    2015-01-01

    Highlights: • Near-wall modeling uncertainties in the RANS particle transport and deposition are addressed in a turbulent duct flow. • Discrete Random Walk (DRW) model and Continuous Random Walk (CRW) model performances are tested. • Several near-wall anisotropic model accuracy is assessed. • Numerous sensitivity studies are performed to recommend a robust, well-validated near-wall model for accurate particle deposition predictions. - Abstract: Dust accumulation in the primary system of a (V)HTR is identified as one of the foremost concerns during a potential accident. Several numerical efforts have focused on the use of RANS methodology to better understand the complex phenomena of fluid–particle interaction at various flow conditions. In the present work, several uncertainties relating to the near-wall modeling of particle transport and deposition are addressed for the RANS approach. The validation analyses are performed in a fully developed turbulent duct flow setup. A standard k − ε turbulence model with enhanced wall treatment is used for modeling the turbulence. For the Lagrangian phase, the performance of a continuous random walk (CRW) model and a discrete random walk (DRW) model for the particle transport and deposition are assessed. For wall bounded flows, it is generally seen that accounting for near wall anisotropy is important to accurately predict particle deposition. The various near-wall correlations available in the literature are either derived from the DNS data or from the experimental data. A thorough investigation into various near-wall correlations and their applicability for accurate particle deposition predictions are assessed. The main outcome of the present work is a well validated turbulence model with optimal near-wall modeling which provides realistic particle deposition predictions

  12. Numerical study comparing RANS and LES approaches on a circulation control airfoil

    International Nuclear Information System (INIS)

    Rumsey, Christopher L.; Nishino, Takafumi

    2011-01-01

    Highlights: → RANS compared with LES for circulation control airfoil. → RANS turbulence models need to account for streamline curvature. → RANS models yield higher lift than LES in spite of predicting similar jet separation. - Abstract: A numerical study over a nominally two-dimensional circulation control airfoil is performed using a large-eddy simulation code and two Reynolds-averaged Navier-Stokes codes. Different Coanda jet blowing conditions are investigated. In addition to investigating the influence of grid density, a comparison is made between incompressible and compressible flow solvers. The incompressible equations are found to yield negligible differences from the compressible equations up to at least a jet exit Mach number of 0.64. The effects of different turbulence models are also studied. Models that do not account for streamline curvature effects tend to predict jet separation from the Coanda surface too late, and can produce non-physical solutions at high blowing rates. Three different turbulence models that account for streamline curvature are compared with each other and with large eddy simulation solutions. All three models are found to predict the Coanda jet separation location reasonably well, but one of the models predicts specific flow field details near the Coanda surface prior to separation much better than the other two. All Reynolds-averaged Navier-Stokes computations produce higher circulation than large eddy simulation computations, with different stagnation point location and greater flow acceleration around the nose onto the upper surface. The precise reasons for the higher circulation are not clear, although it is not solely a function of predicting the jet separation location correctly.

  13. Numerical study comparing RANS and LES approaches on a circulation control airfoil

    Energy Technology Data Exchange (ETDEWEB)

    Rumsey, Christopher L., E-mail: c.l.rumsey@nasa.gov [Computational AeroSciences Branch, NASA Langley Research Center, Hampton, VA 23681-2199 (United States); Nishino, Takafumi [Advanced Supercomputing Division, NASA Ames Research Center, Moffett Field, CA 94035-1000 (United States)

    2011-10-15

    Highlights: > RANS compared with LES for circulation control airfoil. > RANS turbulence models need to account for streamline curvature. > RANS models yield higher lift than LES in spite of predicting similar jet separation. - Abstract: A numerical study over a nominally two-dimensional circulation control airfoil is performed using a large-eddy simulation code and two Reynolds-averaged Navier-Stokes codes. Different Coanda jet blowing conditions are investigated. In addition to investigating the influence of grid density, a comparison is made between incompressible and compressible flow solvers. The incompressible equations are found to yield negligible differences from the compressible equations up to at least a jet exit Mach number of 0.64. The effects of different turbulence models are also studied. Models that do not account for streamline curvature effects tend to predict jet separation from the Coanda surface too late, and can produce non-physical solutions at high blowing rates. Three different turbulence models that account for streamline curvature are compared with each other and with large eddy simulation solutions. All three models are found to predict the Coanda jet separation location reasonably well, but one of the models predicts specific flow field details near the Coanda surface prior to separation much better than the other two. All Reynolds-averaged Navier-Stokes computations produce higher circulation than large eddy simulation computations, with different stagnation point location and greater flow acceleration around the nose onto the upper surface. The precise reasons for the higher circulation are not clear, although it is not solely a function of predicting the jet separation location correctly.

  14. Cheboygan Vessel Base

    Data.gov (United States)

    Federal Laboratory Consortium — Cheboygan Vessel Base (CVB), located in Cheboygan, Michigan, is a field station of the USGS Great Lakes Science Center (GLSC). CVB was established by congressional...

  15. High Performance Marine Vessels

    CERN Document Server

    Yun, Liang

    2012-01-01

    High Performance Marine Vessels (HPMVs) range from the Fast Ferries to the latest high speed Navy Craft, including competition power boats and hydroplanes, hydrofoils, hovercraft, catamarans and other multi-hull craft. High Performance Marine Vessels covers the main concepts of HPMVs and discusses historical background, design features, services that have been successful and not so successful, and some sample data of the range of HPMVs to date. Included is a comparison of all HPMVs craft and the differences between them and descriptions of performance (hydrodynamics and aerodynamics). Readers will find a comprehensive overview of the design, development and building of HPMVs. In summary, this book: Focuses on technology at the aero-marine interface Covers the full range of high performance marine vessel concepts Explains the historical development of various HPMVs Discusses ferries, racing and pleasure craft, as well as utility and military missions High Performance Marine Vessels is an ideal book for student...

  16. 2011 Vessel Density

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  17. 2011 Fishing Vessel Density

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  18. Pressurized Vessel Slurry Pumping

    International Nuclear Information System (INIS)

    Pound, C.R.

    2001-01-01

    This report summarizes testing of an alternate ''pressurized vessel slurry pumping'' apparatus. The principle is similar to rural domestic water systems and ''acid eggs'' used in chemical laboratories in that material is extruded by displacement with compressed air

  19. 2013 Tanker Vessel Density

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  20. Maury Journals - US Vessels

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — U.S. vessels observations, after the 1853 Brussels Conference that set International Maritime Standards, modeled after Maury Marine Standard Observations.

  1. Coastal Logbook Survey (Vessels)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains catch (landed catch) and effort for fishing trips made by vessels that have been issued a Federal permit for the Gulf of Mexico reef fish,...

  2. In-vessel tritium

    International Nuclear Information System (INIS)

    Ueda, Yoshio; Ohya, Kaoru; Ashikawa, Naoko; Ito, Atsushi M.; Kato, Daiji; Kawamura, Gakushi; Takayama, Arimichi; Tomita, Yukihiro; Nakamura, Hiroaki; Ono, Tadayoshi; Kawashima, Hisato; Shimizu, Katsuhiro; Takizuka, Tomonori; Nakano, Tomohide; Nakamura, Makoto; Hoshino, Kazuo; Kenmotsu, Takahiro; Wada, Motoi; Saito, Seiki; Takagi, Ikuji; Tanaka, Yasunori; Tanabe, Tetsuo; Yoshida, Masafumi; Toma, Mitsunori; Hatayama, Akiyoshi; Homma, Yuki; Tolstikhina, Inga Yu.

    2012-01-01

    The in-vessel tritium research is closely related to the plasma-materials interaction. It deals with the edge-plasma-wall interaction, the wall erosion, transport and re-deposition of neutral particles and the effect of neutral particles on the fuel recycling. Since the in-vessel tritium shows a complex nonlinear behavior, there remain many unsolved problems. So far, behaviors of in-vessel tritium have been investigated by two groups A01 and A02. The A01 group performed experiments on accumulation and recovery of tritium in thermonuclear fusion reactors and the A02 group studied theory and simulation on the in-vessel tritium behavior. In the present article, outcomes of the research are reviewed. (author)

  3. Reactor pressure vessel support

    International Nuclear Information System (INIS)

    Butti, J.P.

    1977-01-01

    A link and pin support system provides the primary vertical and lateral support for a nuclear reactor pressure vessel without restricting thermally induced radial and vertical expansion and contraction. (Auth.)

  4. 2013 Cargo Vessel Density

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  5. 2013 Fishing Vessel Density

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  6. 2013 Vessel Density

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  7. Ocean Station Vessel

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Ocean Station Vessels (OSV) or Weather Ships captured atmospheric conditions while being stationed continuously in a single location. While While most of the...

  8. Vessel Sewage Discharges

    Science.gov (United States)

    Vessel sewage discharges are regulated under Section 312 of the Clean Water Act, which is jointly implemented by the EPA and Coast Guard. This homepage links to information on marine sanitation devices and no discharge zones.

  9. Layered Downlink Precoding for C-RAN Systems with Full Dimensional MIMO

    OpenAIRE

    Kang, Jinkyu; Simeone, Osvaldo; Kang, Joonhyuk; Shamai, Shlomo

    2015-01-01

    The implementation of a Cloud Radio Access Network (C-RAN) with Full Dimensional (FD)-MIMO is faced with the challenge of controlling the fronthaul overhead for the transmission of baseband signals as the number of horizontal and vertical antennas grows larger. This work proposes to leverage the special low-rank structure of FD-MIMO channel, which is characterized by a time-invariant elevation component and a time-varying azimuth component, by means of a layered precoding approach, so as to r...

  10. Cost-effective resource allocation in C-RAN with mobile cloud

    OpenAIRE

    Wang, Kezhi; Yang, Kun; Wang, Xinhou; Magurawalage, Chathura Sarathchandra

    2016-01-01

    Taking full advantages of two cloud-based techniques, i.e., cloud radio access network (C-RAN) and mobile cloud computing (MCC), mobile operators will be able to provide the good service to the mobile user as well as increasing their revenue. This paper aims to minimize the mobile operator's cost while at the same time, meet the task time constraints of the mobile users. In particular, we assume that the mobile cloud first completes the tasks for the mobile user and then transmits the results...

  11. Enhancing LTE with Cloud-RAN and Load-Controlled Parasitic Antenna Arrays

    DEFF Research Database (Denmark)

    Artuso, Matteo; Boviz, Dora; Checko, Aleksandra

    2016-01-01

    Cloud radio access network systems, consisting of remote radio heads densely distributed in a coverage area and connected by optical fibers to a cloud infrastructure with large computational capabilities, have the potential to meet the ambitious objectives of next generation mobile networks. Actual...... presented for the fronthaul enables flexibility and elasticity in resource allocation to support BS virtualization. A layered design of information control for the proposed end-to-end solution is presented. The feasibility and effectiveness of such an LCPAA-enabled C-RAN system setup has been validated...

  12. Statistical Multiplexing of Computations in C-RAN with Tradeoffs in Latency and Energy

    DEFF Research Database (Denmark)

    Kalør, Anders Ellersgaard; Agurto Agurto, Mauricio Ignacio; Pratas, Nuno

    2017-01-01

    frame duration, then this may result in additional access latency and limit the energy savings. In this paper we investigate the tradeoff by considering two extreme time-scales for the resource multiplexing: (i) long-term, where the computational resources are adapted over periods much larger than...... the access frame durations; (ii) short-term, where the adaption is below the access frame duration.We develop a general C-RAN queuing model that models the access latency and show, for Poisson arrivals, that long-term multiplexing achieves savings comparable to short-term multiplexing, while offering low...

  13. Investigation on hydrodynamic performance of a marine propeller in oblique flow by RANS computations

    Directory of Open Access Journals (Sweden)

    Jianxi Yao

    2015-01-01

    Full Text Available This paper presents a numerical study on investigating on hydrodynamic characteristics of a marine propeller in oblique flow. The study is achieved by RANS simulations on an open source platform - OpenFOAM. A sliding grid approach is applied to compute the rotating motion of the propeller. Total force and moment acting on blades, as well as average force distributions in one revolution on propeller disk, are obtained for 70 cases of com- binations of advance ratios and oblique angles. The computed results are compared with available experimental data and discussed.

  14. Ran Involved in the Development and Reproduction Is a Potential Target for RNA-Interference-Based Pest Management in Nilaparvata lugens.

    Directory of Open Access Journals (Sweden)

    Kai-Long Li

    Full Text Available Ran (RanGTPase in insects participates in the 20-hydroxyecdysone signal transduction pathway in which downstream genes, FTZ-F1, Krüppel-homolog 1 (Kr-h1 and vitellogenin, are involved. A putative Ran gene (NlRan was cloned from Nilaparvata lugens, a destructive phloem-feeding pest of rice. NlRan has the typical Ran primary structure features that are conserved in insects. NlRan showed higher mRNA abundance immediately after molting and peaked in newly emerged female adults. Among the examined tissues ovary had the highest transcript level, followed by fat body, midgut and integument, and legs. Three days after dsNlRan injection the NlRan mRNA abundance in the third-, fourth-, and fifth-instar nymphs was decreased by 94.3%, 98.4% and 97.0%, respectively. NlFTZ-F1 expression levels in treated third- and fourth-instar nymphs were reduced by 89.3% and 23.8%, respectively. In contrast, NlKr-h1 mRNA levels were up-regulated by 67.5 and 1.5 folds, respectively. NlRan knockdown significantly decreased the body weights, delayed development, and killed >85% of the nymphs at day seven. Two apparent phenotypic defects were observed: (1 Extended body form, and failed to molt; (2 The cuticle at the notum was split open but cannot completely shed off. The newly emerged female adults from dsNlRan injected fifth-instar nymphs showed lower levels of NlRan and vitellogenin, lower weight gain and honeydew excretion comparing with the blank control, and no offspring. Those results suggest that NlRan encodes a functional protein that was involved in development and reproduction. The study established proof of concept that NlRan could serve as a target for dsRNA-based pesticides for N. lugens control.

  15. Reactor pressure vessel design

    International Nuclear Information System (INIS)

    Foehl, J.

    1998-01-01

    As a result of the popularity of the Agencies report 'Neutron Irradiation Embrittlement of Reactor Pressure Vessel Steels' of 1975, it was decided that another report on this broad subject would be of use. In this report, background and contemporary views on specially identified areas of the subject are considered as self-contained chapters, written by experts. In chapter 2, the general principles of reactor pressure vessel design are elaborated. Crack and fracture initiation and propagation are treated in some detail

  16. Graywater Discharges from Vessels

    Science.gov (United States)

    2011-11-01

    metals (e.g., cadmium, chromium, lead, copper , zinc, silver, nickel, and mercury), solids, and nutrients (USEPA, 2008b; USEPA 2010). Wastewater from... flotation ), and disinfection (using ultraviolet light) as compared to traditional Type II MSDs that use either simple maceration and chlorination, or...Coliform Naval Vessels Oceanographic Vessels Small Cruise Ships 25a Vendor 2 Hamann AG Biological Treatment with Dissolved Air Flotation and

  17. LANL Robotic Vessel Scanning

    Energy Technology Data Exchange (ETDEWEB)

    Webber, Nels W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-11-25

    Los Alamos National Laboratory in J-1 DARHT Operations Group uses 6ft spherical vessels to contain hazardous materials produced in a hydrodynamic experiment. These contaminated vessels must be analyzed by means of a worker entering the vessel to locate, measure, and document every penetration mark on the vessel. If the worker can be replaced by a highly automated robotic system with a high precision scanner, it will eliminate the risks to the worker and provide management with an accurate 3D model of the vessel presenting the existing damage with the flexibility to manipulate the model for better and more in-depth assessment.The project was successful in meeting the primary goal of installing an automated system which scanned a 6ft vessel with an elapsed time of 45 minutes. This robotic system reduces the total time for the original scope of work by 75 minutes and results in excellent data accumulation and transmission to the 3D model imaging program.

  18. FFTF and CRBRP reactor vessels

    International Nuclear Information System (INIS)

    Morgan, R.E.

    1977-01-01

    The Fast Flux Test Facility (FFTF) reactor vessel and the Clinch River Breeder Reactor Plant (CRBRP) reactor vessel each serve to enclose a fast spectrum reactor core, contain the sodium coolant, and provide support and positioning for the closure head and internal structure. Each vessel is located in its reactor cavity and is protected by a guard vessel which would ensure continued decay heat removal capability should a major system leak develop. Although the two plants have significantly different thermal power ratings, 400 megawatts for FFTF and 975 megawatts for CRBRP, the two reactor vessels are comparable in size, the CRBRP vessel being approximately 28% longer than the FFTF vessel. The FFTF vessel diameter was controlled by the space required for the three individual In-Vessel Handling Machines and Instrument Trees. Utilization of the triple rotating plug scheme for CRBRP refueling enables packaging of the larger CRBRP core in a vessel the same diameter as the FFTF vessel

  19. In situ SUMOylation analysis reveals a modulatory role of RanBP2 in the nuclear rim and PML bodies

    International Nuclear Information System (INIS)

    Saitoh, Noriko; Uchimura, Yasuhiro; Tachibana, Taro; Sugahara, Satoko; Saitoh, Hisato; Nakao, Mitsuyoshi

    2006-01-01

    SUMO modification plays a critical role in a number of cellular functions including nucleocytoplasmic transport, gene expression, cell cycle and formation of subnuclear structures such as promyelocytic leukemia (PML) bodies. In order to identify the sites where SUMOylation takes place in the cell, we developed an in situ SUMOylation assay using a semi-intact cell system and subsequently combined it with siRNA-based knockdown of nucleoporin RanBP2, also known as Nup358, which is one of the known SUMO E3 proteins. With the in situ SUMOylation assay, we found that both nuclear rim and PML bodies, besides mitotic apparatuses, are major targets for active SUMOylation. The ability to analyze possible SUMO conjugation sites would be a valuable tool to investigate where SUMO E3-like activities and/or SUMO substrates exist in the cell. Specific knockdown of RanBP2 completely abolished SUMOylation along the nuclear rim and dislocated RanGAP1 from the nuclear pore complexes. Interestingly, the loss of RanBP2 markedly reduced the number of PML bodies, in contrast to other, normal-appearing nuclear compartments including the nuclear lamina, nucleolus and chromatin, suggesting a novel link between RanBP2 and PML bodies. SUMOylation facilitated by RanBP2 at the nuclear rim may be a key step for the formation of a particular subnuclear organization. Our data imply that SUMO E3 proteins like RanBP2 facilitate spatio-temporal SUMOylation for certain nuclear structure and function

  20. Validation of Heat Transfer and Film Cooling Capabilities of the 3-D RANS Code TURBO

    Science.gov (United States)

    Shyam, Vikram; Ameri, Ali; Chen, Jen-Ping

    2010-01-01

    The capabilities of the 3-D unsteady RANS code TURBO have been extended to include heat transfer and film cooling applications. The results of simulations performed with the modified code are compared to experiment and to theory, where applicable. Wilcox s k-turbulence model has been implemented to close the RANS equations. Two simulations are conducted: (1) flow over a flat plate and (2) flow over an adiabatic flat plate cooled by one hole inclined at 35 to the free stream. For (1) agreement with theory is found to be excellent for heat transfer, represented by local Nusselt number, and quite good for momentum, as represented by the local skin friction coefficient. This report compares the local skin friction coefficients and Nusselt numbers on a flat plate obtained using Wilcox's k-model with the theory of Blasius. The study looks at laminar and turbulent flows over an adiabatic flat plate and over an isothermal flat plate for two different wall temperatures. It is shown that TURBO is able to accurately predict heat transfer on a flat plate. For (2) TURBO shows good qualitative agreement with film cooling experiments performed on a flat plate with one cooling hole. Quantitatively, film effectiveness is under predicted downstream of the hole.

  1. Comparisons of LES and RANS Computations with PIV Experiments on a Cylindrical Cavity Flow

    Directory of Open Access Journals (Sweden)

    Wen-Tao Su

    2013-01-01

    Full Text Available A comparison study on the numerical computations by large eddy simulation (LES and Reynolds-averaged Navier-Stokes (RANS methods with experiment on a cylindrical cavity flow was conducted in this paper. Numerical simulations and particle image velocimetry (PIV measurement were performed for two Reynolds numbers of the flow at a constant aspect ratio of H/R = 2.4 (R is the radius of the cylindrical cavity, and H is liquid level. The three components of velocity were extracted from 100 sequential PIV measured velocity frames with averaging, in order to illustrate the axial jet flow evolution and circulation distribution in the radial direction. The results show that LES can reproduce well the fine structure inside the swirling motions in both the meridional and the horizontal planes, as well as the distributions of velocity components and the circulation, in good agreement with experimental results, while the RANS method only provided a rough trend of inside vortex structure. Based on the analysis of velocity profiles at various locations, it indicates that LES is more suitable for predicting the complex flow characteristics inside complicated three-dimensional geometries.

  2. Spalart–Allmaras model apparent transition and RANS simulations of laminar separation bubbles on airfoils

    International Nuclear Information System (INIS)

    Crivellini, Andrea; D’Alessandro, Valerio

    2014-01-01

    Highlights: • RANS simulation of laminar separation bubbles. • Spalart–Allamaras unexpected capability. • Straightforward implementation of our SA modifications. • Applications of a high order DG incompressible solver. - Abstract: The present paper deals with the Reynolds Averaged Navier–Stokes (RANS) simulation of Laminar Separation Bubble (LSB). This phenomenon is of large interest in several engineering fields, such as the study of wind turbines, unmanned aerial vehicles (UAV) and micro-air vehicles (MAV) characterized by a low operating Reynolds number. In such contexts a laminar boundary layer separation followed by a turbulent transition and afterwards by a turbulent reattachment may appear in the flow-field. The main novelty of this work is that an almost standard Spalart–Allmaras (SA) model, without additional equations for transition modeling, was successfully employed. The result achieved is very surprising being the model not developed for this purpose, but for fully-turbulent flows or for cases with imposed transition location. This result is of large interest, since the SA model is widely used in commercial, open-source and research codes. However, our approach cannot be advocated to predict natural transition within an attached boundary layer, indeed it is only able to deal with transitions triggered by a separated flow. The reliability and accuracy of our approach are here proved computing, by means of a high-order Discontinuous Galerkin (DG) incompressible solver, the flow-field over two airfoils at different flow regimes showing the formation of a LSB

  3. Application of a New Hybrid RANS/LES Modeling Paradigm to Compressible Flow

    Science.gov (United States)

    Oliver, Todd; Pederson, Clark; Haering, Sigfried; Moser, Robert

    2017-11-01

    It is well-known that traditional hybrid RANS/LES modeling approaches suffer from a number of deficiencies. These deficiencies often stem from overly simplistic blending strategies based on scalar measures of turbulence length scale and grid resolution and from use of isotropic subgrid models in LES regions. A recently developed hybrid modeling approach has shown promise in overcoming these deficiencies in incompressible flows [Haering, 2015]. In the approach, RANS/LES blending is accomplished using a hybridization parameter that is governed by an additional model transport equation and is driven to achieve equilibrium between the resolved and unresolved turbulence for the given grid. Further, the model uses an tensor eddy viscosity that is formulated to represent the effects of anisotropic grid resolution on subgrid quantities. In this work, this modeling approach is extended to compressible flows and implemented in the compressible flow solver SU2 (http://su2.stanford.edu/). We discuss both modeling and implementation challenges and show preliminary results for compressible flow test cases with smooth wall separation.

  4. Turbulence-induced heat transfer in PBMR core using LES and RANS

    International Nuclear Information System (INIS)

    Lee, Jung-Jae; Yoon, Su-Jong; Park, Goon-Cherl; Lee, Won-Jae

    2007-01-01

    This paper introduces the results of numerical simulations on flow fields and relevant heat transfer in the pebble bed reactor (PBR) core, since the coolant passes a highly complicated random flow path with a high Reynolds number, an appropriate treatment of the turbulence is required. A set of simple experiments for the flow over a circular cylinder with heat transfer was conducted to finally select the large eddy simulation (LES) and k-ω model among the considering Reynolds-averaged Navier-Stokes (RANS) models for PBR application. Using these models, the PBR cores, whose geometries were simplified to the body-centered cubical (BCC) and face-centered cubical (FCC) structures, were simulated. A larger pressure drop, a more random flow field, a higher vorticity magnitude and a higher temperature at the local hot spots on the pebble surface were found in the results of the LES than in those of RANS for both geometries. In cases of the LES, the flow structures were resolved up to the grid scales. Irregular distributions of the flow and local heat transfer were found in the BCC core, while relatively regular distributions for the FCC core. The turbulent nature of the coolant flow in the pebble core evidently affected the fuel surface temperature distribution. (author)

  5. Development of a Hybrid RANS/LES Method for Turbulent Mixing Layers

    Science.gov (United States)

    Georgiadis, Nicholas J.; Alexander, J. Iwan D.; Reshotko, Eli

    2001-01-01

    Significant research has been underway for several years in NASA Glenn Research Center's nozzle branch to develop advanced computational methods for simulating turbulent flows in exhaust nozzles. The primary efforts of this research have concentrated on improving our ability to calculate the turbulent mixing layers that dominate flows both in the exhaust systems of modern-day aircraft and in those of hypersonic vehicles under development. As part of these efforts, a hybrid numerical method was recently developed to simulate such turbulent mixing layers. The method developed here is intended for configurations in which a dominant structural feature provides an unsteady mechanism to drive the turbulent development in the mixing layer. Interest in Large Eddy Simulation (LES) methods have increased in recent years, but applying an LES method to calculate the wide range of turbulent scales from small eddies in the wall-bounded regions to large eddies in the mixing region is not yet possible with current computers. As a result, the hybrid method developed here uses a Reynolds-averaged Navier-Stokes (RANS) procedure to calculate wall-bounded regions entering a mixing section and uses a LES procedure to calculate the mixing-dominated regions. A numerical technique was developed to enable the use of the hybrid RANS-LES method on stretched, non-Cartesian grids. With this technique, closure for the RANS equations is obtained by using the Cebeci-Smith algebraic turbulence model in conjunction with the wall-function approach of Ota and Goldberg. The LES equations are closed using the Smagorinsky subgrid scale model. Although the function of the Cebeci-Smith model to replace all of the turbulent stresses is quite different from that of the Smagorinsky subgrid model, which only replaces the small subgrid turbulent stresses, both are eddy viscosity models and both are derived at least in part from mixing-length theory. The similar formulation of these two models enables the RANS

  6. A numerical study on manoeuvrability of wind turbine installation vessel using OpenFOAM

    Directory of Open Access Journals (Sweden)

    Sungwook Lee

    2015-05-01

    Full Text Available In this study, a numerical prediction method on manoeuvrability of Wind Turbine Installation Vessel (WTIV is presented. Planar Motion Mechanism (PMM captive test for the bare hull of WTIV is carried out in the model basin and compared with the numerical results using RANS simulation based on Open-source Field Operation And Manipulation (OpenFOAM calculation to validate the developed method. The manoeuvrability of WTIV with skeg and/or without skeg is investigated using the numerical approach along with the captive model test. In the numerical calculations, the dynamic stability index which indicates the course keeping ability is evaluated and compared for three different hull configurations i.e. bare hull and other two hulls with center skeg and twin skeg. This paper proves that the numerical approach using RANS simulation can be readily applied to estimate the manoeuvrability of WTIV at the initial design stage.

  7. Acrylic vessel cleaning tests

    International Nuclear Information System (INIS)

    Earle, D.; Hahn, R.L.; Boger, J.; Bonvin, E.

    1997-01-01

    The acrylic vessel as constructed is dirty. The dirt includes blue tape, Al tape, grease pencil, gemak, the glue or residue form these tapes, finger prints and dust of an unknown composition but probably mostly acrylic dust. This dirt has to be removed and once removed, the vessel has to be kept clean or at least to be easily cleanable at some future stage when access becomes much more difficult. The authors report on the results of a series of tests designed: (a) to prepare typical dirty samples of acrylic; (b) to remove dirt stuck to the acrylic surface; and (c) to measure the optical quality and Th concentration after cleaning. Specifications of the vessel call for very low levels of Th which could come from tape residues, the grease pencil, or other sources of dirt. This report does not address the concerns of how to keep the vessel clean after an initial cleaning and during the removal of the scaffolding. Alconox is recommended as the cleaner of choice. This acrylic vessel will be used in the Sudbury Neutrino Observatory

  8. Ran GTPase-activating protein 1 is a therapeutic target in diffuse large B-cell lymphoma.

    Directory of Open Access Journals (Sweden)

    Kung-Chao Chang

    Full Text Available Lymphoma-specific biomarkers contribute to therapeutic strategies and the study of tumorigenesis. Diffuse large B-cell lymphoma (DLBCL is the most common type of malignant lymphoma. However, only 50% of patients experience long-term survival after current treatment; therefore, developing novel therapeutic strategies is warranted. Comparative proteomic analysis of two DLBCL lines with a B-lymphoblastoid cell line (LCL showed differential expression of Ran GTPase-activating protein 1 (RanGAP1 between them, which was confirmed using immunoblotting. Immunostaining showed that the majority of DLBCLs (92%, 46/50 were RanGAP1(+, while reactive lymphoid hyperplasia (n = 12 was RanGAP1(+ predominantly in germinal centers. RanGAP1 was also highly expressed in other B-cell lymphomas (BCL, n = 180 with brisk mitotic activity (B-lymphoblastic lymphoma/leukemia: 93%, and Burkitt lymphoma: 95% or cell-cycle dysregulation (mantle cell lymphoma: 83%, and Hodgkin's lymphoma 91%. Interestingly, serum RanGAP1 level was higher in patients with high-grade BCL (1.71 ± 2.28 ng/mL, n = 62 than in low-grade BCL (0.75 ± 2.12 ng/mL, n = 52 and healthy controls (0.55 ± 1.58 ng/mL, n = 75 (high-grade BCL vs. low-grade BCL, p = 0.002; high-grade BCL vs. control, p < 0.001, Mann-Whitney U test. In vitro, RNA interference of RanGAP1 showed no effect on LCL but enhanced DLBCL cell death (41% vs. 60%; p = 0.035 and cell-cycle arrest (G0/G1: 39% vs. 49%, G2/M: 19.0% vs. 7.5%; p = 0.030 along with decreased expression of TPX2 and Aurora kinases, the central regulators of mitotic cell division. Furthermore, ON 01910.Na (Estybon, a multikinase inhibitor induced cell death, mitotic cell arrest, and hyperphosphorylation of RanGAP1 in DLBCL cell lines but no effects in normal B and T cells. Therefore, RanGAP1 is a promising marker and therapeutic target for aggressive B-cell lymphoma, especially DLBCL.

  9. Radioactive liquid containing vessel

    International Nuclear Information System (INIS)

    Sakurada, Tetsuo; Kawamura, Hironobu.

    1993-01-01

    Cooling jackets are coiled around the outer circumference of a container vessel, and the outer circumference thereof is covered with a surrounding plate. A liquid of good conductivity (for example, water) is filled between the cooling jackets and the surrounding plate. A radioactive liquid is supplied to the container vessel passing through a supply pipe and discharged passing through a discharge pipe. Cooling water at high pressure is passed through the cooling water jackets in order to remove the heat generated from the radioactive liquid. Since cooling water at high pressure is thus passed through the coiled pipes, the wall thickness of the container vessel and the cooling water jackets can be reduced, thereby enabling to reduce the cost. Further, even if the radioactive liquid is leaked, there is no worry of contaminating cooling water, to prevent contamination. (I.N.)

  10. GTPase Ran strongly accumulates at the kinetochores of somatic chromosomes in the spermatogonial mitoses of Acricotopus lucidus (Diptera, Chironomidae).

    Science.gov (United States)

    Staiber, Wolfgang

    2014-07-01

    Unequal chromosome segregation and spindle formation occurs in the last gonial mitosis in the germ line of the chironomid Acricotopus lucidus. During this differential mitosis, all germ line-limited chromosomes (=Ks) migrate undivided to only one pole of the cell, while the somatic chromosomes (=Ss) first remain in the metaphase plane, and with the arrival of the Ks at the pole, they then separate equally. The evolutionarily conserved GTPase Ran plays a crucial role in many cellular processes. This includes the regulation of microtubule nucleation and stabilisation at kinetochores and of spindle assembly during mitosis, which is promoted by a RanGTP concentration gradient that forms around the mitotic chromosomes (Kalab et al. in Science 295:2452-2456, 2002, Nature 440:697-701, 2006). In the present study, a strong accumulation of Ran was detected by immunofluorescence at the kinetochores of the Ss in normal gonial and differential gonial mitoses of males of A. lucidus. In contrast, no Ran accumulation was observed at the kinetochores of the Ss in the metaphases of brain ganglia mitoses or of aberrant spermatocytes or in metaphases I and II of spermatocyte meiotic divisions. Likewise, there was no accumulation at the kinetochores of Drosophila melanogaster mitotic chromosomes from larval brains. The specific accumulation of Ran at the kinetochores of the Ss in differential gonial mitoses of A. lucidus strongly suggests that Ran is involved in a mechanism acting in this exceptional mitosis, which retains the Ss at the metaphase plane and prevents a premature separation and unequal segregation of the Ss during monopolar migration of the Ks.

  11. Synchronization challenges in packet-based Cloud-RAN fronthaul for mobile networks

    DEFF Research Database (Denmark)

    Checko, Aleksandra; Juul, Anders Christian; Christiansen, Henrik Lehrmann

    2015-01-01

    In this paper, we look at reusing existing packet-based network (e.g. Ethernet) to possibly decrease deployment costs of fronthaul Cloud Radio Access Network (C-RAN) network and cost of Baseband Unit (BBU) resources. The challenge of this solution is that it requires mobile traffic (until now...... transmitted over synchronous protocols) to traverse the asynchronous Ethernet without losing synchronization. We analyze synchronization requirements of mobile networks and present an overview of solutions that fulfill them in traditional mobile networks. Then we elaborate on challenges that packet-based...... fronthaul imposes. We analyze possible contributions to frequency and phase error. We verify the feasibility of using the IEEE 1588v2 also know as Precision Time Protocol (PTP) for providing accurate phase and frequency synchronization. The study is based on simulations made in OPNET modeler. Thereby we...

  12. Investigation on the wake evolution of contra-rotating propeller using RANS computation and SPIV measurement

    Directory of Open Access Journals (Sweden)

    Kwang-Jun Paik

    2015-05-01

    Full Text Available The wake characteristics of Contra-Rotating Propeller (CRP were investigated using numerical simulation and flow measurement. The numerical simulation was carried out with a commercial CFD code based on a Reynolds Averaged Navier-Stokes (RANS equations solver, and the flow measurement was performed with Stereoscopic Particle Image Velocimetry (SPIV system. The simulation results were validated through the comparison with the experiment results measured around the leading edge of rudder to investigate the effect of propeller operation under the conditions without propeller, with forward propeller alone, and with both forward and aft propellers. The evolution of CRP wake was analyzed through velocity and vorticity contours on three transverse planes and one longitudinal plane based on CFD results. The trajectories of propeller tip vortex core in the cases with and without aft propeller were also compared, and larger wake contraction with CRP was confirmed.

  13. RANS modeling of scalar dispersion from localized sources within a simplified urban-area model

    Science.gov (United States)

    Rossi, Riccardo; Capra, Stefano; Iaccarino, Gianluca

    2011-11-01

    The dispersion of a passive scalar downstream a localized source within a simplified urban-like geometry is examined by means of RANS scalar flux models. The computations are conducted under conditions of neutral stability and for three different incoming wind directions (0°, 45°, 90°) at a roughness Reynolds number of Ret = 391. A Reynolds stress transport model is used to close the flow governing equations whereas both the standard eddy-diffusivity closure and algebraic flux models are employed to close the transport equation for the passive scalar. The comparison with a DNS database shows improved reliability from algebraic scalar flux models towards predicting both the mean concentration and the plume structure. Since algebraic flux models do not increase substantially the computational effort, the results indicate that the use of tensorial-diffusivity can be promising tool for dispersion simulations for the urban environment.

  14. A Synthesis of Hybrid RANS/LES CFD Results for F-16XL Aircraft Aerodynamics

    Science.gov (United States)

    Luckring, James M.; Park, Michael A.; Hitzel, Stephan M.; Jirasek, Adam; Lofthouse, Andrew J.; Morton, Scott A.; McDaniel, David R.; Rizzi, Arthur M.

    2015-01-01

    A synthesis is presented of recent numerical predictions for the F-16XL aircraft flow fields and aerodynamics. The computational results were all performed with hybrid RANS/LES formulations, with an emphasis on unsteady flows and subsequent aerodynamics, and results from five computational methods are included. The work was focused on one particular low-speed, high angle-of-attack flight test condition, and comparisons against flight-test data are included. This work represents the third coordinated effort using the F-16XL aircraft, and a unique flight-test data set, to advance our knowledge of slender airframe aerodynamics as well as our capability for predicting these aerodynamics with advanced CFD formulations. The prior efforts were identified as Cranked Arrow Wing Aerodynamics Project International, with the acronyms CAWAPI and CAWAPI-2. All information in this paper is in the public domain.

  15. Flow field analysis of a pentagonal-shaped bridge deck by unsteady RANS

    Directory of Open Access Journals (Sweden)

    Md. Naimul Haque

    2016-01-01

    Full Text Available Long-span cable-stayed bridges are susceptible to dynamic wind effects due to their inherent flexibility. The fluid flow around the bridge deck should be well understood for the efficient design of an aerodynamically stable long-span bridge system. In this work, the aerodynamic features of a pentagonal-shaped bridge deck are explored numerically. The analytical results are compared with past experimental work to assess the capability of two-dimensional unsteady RANS simulation for predicting the aerodynamic features of this type of deck. The influence of the bottom plate slope on aerodynamic response and flow features was investigated. By varying the Reynolds number (2 × 104 to 20 × 104 the aerodynamic behavior at high wind speeds is clarified.

  16. RANS simulation of cavitation and hull pressure fluctuation for marine propeller operating behind-hull condition

    Science.gov (United States)

    Paik, Kwang-Jun; Park, Hyung-Gil; Seo, Jongsoo

    2013-12-01

    Simulations of cavitation flow and hull pressure fluctuation for a marine propeller operating behind a hull using the unsteady Reynolds-Averaged Navier-Stokes equations (RANS) are presented. A full hull body submerged under the free surface is modeled in the computational domain to simulate directly the wake field of the ship at the propeller plane. Simulations are performed in design and ballast draught conditions to study the effect of cavitation number. And two propellers with slightly different geometry are simulated to validate the detectability of the numerical simulation. All simulations are performed using a commercial CFD software FLUENT. Cavitation patterns of the simulations show good agreement with the experimental results carried out in Samsung CAvitation Tunnel (SCAT). The simulation results for the hull pressure fluctuation induced by a propeller are also compared with the experimental results showing good agreement in the tendency and amplitude, especially, for the first blade frequency.

  17. RANS simulation of cavitation and hull pressure fluctuation for marine propeller operating behind-hull condition

    Directory of Open Access Journals (Sweden)

    Kwang-Jun Paik

    2013-12-01

    Full Text Available Simulations of cavitation flow and hull pressure fluctuation for a marine propeller operating behind a hull using the unsteady Reynolds-Averaged Navier-Stokes equations (RANS are presented. A full hull body submerged under the free surface is modeled in the computational domain to simulate directly the wake field of the ship at the propeller plane. Simulations are performed in design and ballast draught conditions to study the effect of cavitation number. And two propellers with slightly different geometry are simulated to validate the detectability of the numerical simulation. All simulations are performed using a commercial CFD software FLUENT. Cavitation patterns of the simulations show good agreement with the experimental results carried out in Samsung CAvitation Tunnel (SCAT. The simulation results for the hull pressure fluctuation induced by a propeller are also compared with the experimental results showing good agreement in the tendency and amplitude, especially, for the first blade frequency.

  18. Optimizing small cell deployment by the use of C-RANs

    DEFF Research Database (Denmark)

    Checko, Aleksandra; Holm, Henrik Laumand; Christiansen, Henrik Lehrmann

    2014-01-01

    A Cloud Radio Access Network (C-RAN) is a novel mobile network architecture that has the potential to support extremely dense mobile network deployments enhancing the network capacity while offering cost savings on baseband resources. In this work we analyze cell traffic profiles and evaluate...... the conditions that impact the statistical multiplexing gain in the Baseband Unit (BBU) Pool. We conclude on the set of parameters that maximize the statistical multiplexing gain, leading to the highest potential cost savings. We then propose a packet based architecture that can adapt to changing traffic...... conditions. Furthermore, based on theoretical calculations and Network simulations we present considerations on deployment scenarios to optimize green field deployments in terms of Total Cost of Ownership (TCO). This involves optimizing the mix of cells with different traffic profiles and the BBU Pool...

  19. Pressure vessel integrity 1991

    International Nuclear Information System (INIS)

    Bhandari, S.; Doney, R.O.; McDonald, M.S.; Jones, D.P.; Wilson, W.K.; Pennell, W.E.

    1991-01-01

    This volume contains papers relating to the structural integrity assessment of pressure vessels and piping, with special emphasis on nuclear industry applications. The papers were prepared for technical sessions developed under the sponsorship of the ASME Pressure Vessels and Piping Division Committees for Codes and Standards, Computer Technology, Design and Analysis, and Materials Fabrication. They were presented at the 1991 Pressure Vessels and Piping Division Conference in San Diego, California, June 23-27. The primary objective of the sponsoring organization is to provide a forum for the dissemination and discussion of information on development and application of technology for the structural integrity assessment of pressure vessels and piping. This publication includes contributions from authors from Australia, France, Japan, Sweden, Switzerland, the United Kingdom, and the United States. The papers here are organized in six sections, each with a particular emphasis as indicated in the following section titles: Fracture Technology Status and Application Experience; Crack Initiation, Propagation and Arrest; Ductile Tearing; Constraint, Stress State, and Local-Brittle-Zones Effects; Computational Techniques for Fracture and Corrosion Fatigue; and Codes and Standards for Fatigue, Fracture and Erosion/Corrosion

  20. The reactor vessel steels

    International Nuclear Information System (INIS)

    Bilous, W.; Hajewska, E.; Szteke, W.; Przyborska, M.; Wasiak, J.; Wieczorkowski, M.

    2005-01-01

    In the paper the fundamental steels using in the construction of pressure vessel water reactor are discussed. The properties of these steels as well as the influence of neutron irradiation on its degradation in the time of exploitation are also done. (authors)

  1. Vacuum distilling vessel

    Energy Technology Data Exchange (ETDEWEB)

    Reik, H

    1928-12-27

    Vacuum distilling vessel for mineral oil and the like, characterized by the ring-form or polyconal stiffeners arranged inside, suitably eccentric to the casing, being held at a distance from the casing by connecting members of such a height that in the resulting space if necessary can be arranged vapor-distributing pipes and a complete removal of the residue is possible.

  2. Visualization of vessel traffic

    NARCIS (Netherlands)

    Willems, C.M.E.

    2011-01-01

    Moving objects are captured in multivariate trajectories, often large data with multiple attributes. We focus on vessel traffic as a source of such data. Patterns appearing from visually analyzing attributes are used to explain why certain movements have occurred. In this research, we have developed

  3. GOLD PRESSURE VESSEL SEAL

    Science.gov (United States)

    Smith, A.E.

    1963-11-26

    An improved seal between the piston and die member of a piston-cylinder type pressure vessel is presented. A layer of gold, of sufficient thickness to provide an interference fit between the piston and die member, is plated on the contacting surface of at least one of the members. (AEC)

  4. Reactor vessel stud tensioner

    International Nuclear Information System (INIS)

    Malandra, L.J.; Beer, R.W.; Salton, R.B.; Spiegelman, S.R.; Cognevich, M.L.

    1982-01-01

    A quick-acting stud tensioner, for facilitating the loosening or tightening of a stud nut on a reactor vessel stud, has gripper jaws which when the tensioner is lowered into engagement with the upper end of the stud are moved inwards to grip the upper end and which when the tensioner is lifted move outward to release the upper end. (author)

  5. RANS-based CFD simulations of sodium fast reactor wire-wrapped pin bundles

    International Nuclear Information System (INIS)

    Pointer, W. D.; Thomas, J.; Fanning, T.; Fischer, P.; Siegel, A.; Smith, J.; Tokuhiro, A.

    2009-01-01

    In response to recent renewed interest in the development of advanced fast reactors, an effort is underway to develop a high-performance computational multi-physics simulation suite for the design and safety analysis of sodium cooled fast reactors. Within the multi-resolution thermal-hydraulics simulation component of this framework, high-resolution spectral large eddy simulation methods are used to improve turbulence models from coarser resolution Reynolds-averaged Navier-Stokes methods, and in turn, that data is used to improve or extend correlations used in traditional sub-channel tools. These ongoing studies provide the foundation for the development of the intermediate RANS-based resolution level. Prior work has focused on the benchmarking of flow field predictions on in 7-pin, 19-pin, and 37-pin fuel assemblies. The present work extends these studies to 217-pin assemblies in support of initial efforts to benchmark heat transfer predictions using the RANS models against conventional sub-channel models. In an effort to reduce the number of computational cells required to describe a 217-pin geometry, the effects of simplification of the geometric description of the contact point between the wire and the pin are investigated. The advantages of using polyhedral-based meshing methods rather than trimmed cell meshing methods have been demonstrated, and the effects of changes in axial mesh resolution in these meshes have been investigated. Results show that the geometric simplification has little impact on predicted flow fields, as does the use of a polyhedral mesh of comparable mesh density in place of the original trimmed cell mesh. While reducing axial mesh density has a notable impact on the velocity field, reducing predicted exchange velocities between adjacent subchannels by as much 25%, the impact on predicted temperature fields is negligible. (authors)

  6. Performance evaluation of RANS-based turbulence models in simulating a honeycomb heat sink

    Science.gov (United States)

    Subasi, Abdussamet; Ozsipahi, Mustafa; Sahin, Bayram; Gunes, Hasan

    2017-07-01

    As well-known, there is not a universal turbulence model that can be used to model all engineering problems. There are specific applications for each turbulence model that make it appropriate to use, and it is vital to select an appropriate model and wall function combination that matches the physics of the problem considered. Therefore, in this study, performance of six well-known Reynolds-Averaged Navier-Stokes ( RANS) based turbulence models which are the Standard k {{-}} ɛ, the Renormalized Group k- ɛ, the Realizable k- ɛ, the Reynolds Stress Model, the k- ω and the Shear Stress Transport k- ω and accompanying wall functions which are the standard, the non-equilibrium and the enhanced are evaluated via 3D simulation of a honeycomb heat sink. The CutCell method is used to generate grid for the part including heat sink called test section while a hexahedral mesh is employed to discretize to inlet and outlet sections. A grid convergence study is conducted for verification process while experimental data and well-known correlations are used to validate the numerical results. Prediction of pressure drop along the test section, mean base plate temperature of the heat sink and temperature at the test section outlet are regarded as a measure of the performance of employed models and wall functions. The results indicate that selection of turbulence models and wall functions has a great influence on the results and, therefore, need to be selected carefully. Hydraulic and thermal characteristics of the honeycomb heat sink can be determined in a reasonable accuracy using RANS- based turbulence models provided that a suitable turbulence model and wall function combination is selected.

  7. Capacity Bounds on the Downlink of Symmetric, Multi-Relay, Single-Receiver C-RAN Networks

    Directory of Open Access Journals (Sweden)

    Shirin Saeedi Bidokhti

    2017-11-01

    Full Text Available The downlink of symmetric Cloud Radio Access Networks (C-RANs with multiple relays and a single receiver is studied. Lower and upper bounds are derived on the capacity. The lower bound is achieved by Marton’s coding, which facilitates dependence among the multiple-access channel inputs. The upper bound uses Ozarow’s technique to augment the system with an auxiliary random variable. The bounds are studied over scalar Gaussian C-RANs and are shown to meet and characterize the capacity for interesting regimes of operation.

  8. RANS based CFD methodology for a real scale 217-pin wire-wrapped fuel assembly of KAERI PGSFR

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Jae-Ho, E-mail: jhjeong@kaeri.re.kr [Korea Atomic Energy Research Institute, 989-111 Daedeok-daero, Yuseoung-gu, Daejeon (Korea, Republic of); Song, Min-Seop [Department of Nuclear Engineering, Seoul National University, 559 Gwanak-ro, Gwanak-gu, Seoul (Korea, Republic of); Lee, Kwi-Lim [Korea Atomic Energy Research Institute, 989-111 Daedeok-daero, Yuseoung-gu, Daejeon (Korea, Republic of)

    2017-03-15

    Highlights: • This paper presents a suitable way for a practical RANS based CFD methodology which is applicable to real scale 217-pin wire-wrapped fuel assembly of KAERI PGSFR. • A key point of differentiation of the RANS based CFD methodology in this study is adapting an innovative grid generation method using a fortran based in-house code with a GGI function in a general-purpose commercial CFD code, CFX. • The RANS based CFD methodology is implemented with high resolution scheme and SST turbulence model in the 7-pin 37-pin, and 127-pin wire-wrapped fuel assembly of PNC and JNC. Furthermore, the RANS based CFD methodology can be successfully extended to the real scale 217-pin wire-wrapped fuel bundles of KAERI PGSFR. • Three-dimensional thermal-hydraulic characteristics have been also investigated briefly. - Abstract: This paper presents a suitable way for a practical RANS (Reynolds Averaged Navier-Stokes simulation) based CFD (Computational Fluid Dynamics) methodology which is applicable to real scale 217-pin wire-wrapped fuel assembly of KAERI (Korea Atomic Energy Research Institute) PGSFR (Prototype Gen-IV Sodium-cooled Fast Reactor). The main purpose of the current study is to support license issue for the KAERI PGSFR core safety and to elucidate thermal-hydraulic characteristics in a 217-pin wire-wrapped fuel assembly of KAERI PGSFR. A key point of differentiation of the RANS based CFD methodology in this study is adapting an innovative grid generation method using a fortran based in-house code with a GGI (General Grid Interface) function in a general-purpose commercial CFD code, CFX. The innovative grid generation method with GGI function can achieve to simulate a real wire shape with minimizing cell skewness. The RANS based CFD methodology is implemented with high resolution scheme in convection term and SST (Shear Stress Transport) turbulence model in the 7-pin 37-pin, and 127-pin wire-wrapped fuel assembly of PNC (Power reactor and Nuclear fuel

  9. A strong loss-of-function mutation in RAN1 results in constitutive activation of the ethylene response pathway as well as a rosette-lethal phenotype

    Science.gov (United States)

    Woeste, K. E.; Kieber, J. J.; Evans, M. L. (Principal Investigator)

    2000-01-01

    A recessive mutation was identified that constitutively activated the ethylene response pathway in Arabidopsis and resulted in a rosette-lethal phenotype. Positional cloning of the gene corresponding to this mutation revealed that it was allelic to responsive to antagonist1 (ran1), a mutation that causes seedlings to respond in a positive manner to what is normally a competitive inhibitor of ethylene binding. In contrast to the previously identified ran1-1 and ran1-2 alleles that are morphologically indistinguishable from wild-type plants, this ran1-3 allele results in a rosette-lethal phenotype. The predicted protein encoded by the RAN1 gene is similar to the Wilson and Menkes disease proteins and yeast Ccc2 protein, which are integral membrane cation-transporting P-type ATPases involved in copper trafficking. Genetic epistasis analysis indicated that RAN1 acts upstream of mutations in the ethylene receptor gene family. However, the rosette-lethal phenotype of ran1-3 was not suppressed by ethylene-insensitive mutants, suggesting that this mutation also affects a non-ethylene-dependent pathway regulating cell expansion. The phenotype of ran1-3 mutants is similar to loss-of-function ethylene receptor mutants, suggesting that RAN1 may be required to form functional ethylene receptors. Furthermore, these results suggest that copper is required not only for ethylene binding but also for the signaling function of the ethylene receptors.

  10. PDX vacuum vessel stress analysis

    International Nuclear Information System (INIS)

    Nikodem, Z.D.

    1975-01-01

    A stress analysis of PDX vacuum vessel is described and the summary of results is presented. The vacuum vessel is treated as a toroidal shell of revolution subjected to an internal vacuum. The critical buckling pressure is calculated. The effects of the geometrical discontinuity at the juncture of toroidal shell head and cylindrical outside wall, and the concavity of the cylindrical wall are examined. An effect of the poloidal field coil supports and the vessel outside supports on the stress distribution in the vacuum vessel is determined. A method evaluating the influence of circular ports in the vessel wall on the stress level in the vessel is outlined

  11. RANS / LES coupling applied to high Reynolds number turbulent flows of the nuclear industry; Application du couplage RANS / LES aux ecoulements turbulents a haut nombre de Reynolds de l'industrie nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Benarafa, Y

    2005-12-15

    The main issue to perform a computational study of high Reynolds numbered turbulent flows consists on predicting their unsteadiness without implying a tremendous computational cost. First, the main drawbacks of large-eddy simulation with standard wall model on a coarse mesh for a plane channel flow are highlighted. To correct these drawbacks two coupling RANS/LES methods have been proposed. The first one relies on a sophisticated wall model (TBLE) which consists on solving Thin Boundary Layer Equations with a RANS type turbulent closure in the near wall region. The second one consists on a RANS/LES methods have been proposed. The second one consists on a RANS/LES coupling method using a forcing term approach. These various approaches have been implemented in the TRIO-U code developed at CEA (French Atomic Center) at Grenoble, France. The studied flow configurations are the fully developed plane channel flow and a flow around a surface-mounted cubical obstacle. Both approaches provide encouraging results and allow a surface-mounted cubical obstacle. Both approaches provide encouraging results and allow unsteady simulations for a low computational cost. (author)

  12. Vessels in Transit - Web Tool

    Data.gov (United States)

    Department of Transportation — A web tool that provides real-time information on vessels transiting the Saint Lawrence Seaway. Visitors may sort by order of turn, vessel name, or last location in...

  13. Reactor vessel sealing plug

    International Nuclear Information System (INIS)

    Dooley, R.A.

    1986-01-01

    An apparatus is described for sealing a cold leg nozzle of a nuclear reactor pressure vessel from a remote location comprising: at least one sealing plug for mechanically sealing the nozzle from the inside of the reactor pressure vessel. The sealing plug includes a plate and a cone assembly having an end part receptive in the nozzle, the plate being axially moveable relative to the cone assembly. The plate and cone assembly have confronting bevelled edges defining an opening therebetween. A primary O-ring is disposed about the opening and is supported on the bevelled edges, the plate being guidably mounted to the cone assembly for movement toward the cone assembly to radially expand the primary O-ring into sealing engagement with the nozzle. A means is included for providing relative movement between the outer plate and the cone assembly

  14. Mobile nuclear reactor containment vessel

    International Nuclear Information System (INIS)

    Thompson, R.E.; Spurrier, F.R.; Jones, A.R.

    1978-01-01

    A containment vessel for use in mobile nuclear reactor installations is described. The containment vessel completely surrounds the entire primary system, and is located as close to the reactor primary system components as is possible in order to minimize weight. In addition to being designed to withstand a specified internal pressure, the containment vessel is also designed to maintain integrity as a containment vessel in case of a possible collision accident

  15. Nuclear reactor vessel inspection apparatus

    International Nuclear Information System (INIS)

    Blackstone, E.G.; Lofy, R.A.; Williams, L.P.

    1979-01-01

    Apparatus for the in situ inspection of a nuclear reactor vessel to detect the location and character of flaws in the walls of the vessel, in the welds joining the various sections of the vessel, in the welds joining attachments such as nozzles, elbows and the like to the reactor vessel and in such attachments wherein an inspection head carrying one or more ultrasonic transducers follows predetermined paths in scanning the various reactor sections, welds and attachments

  16. Reactor vessel stud closure system

    International Nuclear Information System (INIS)

    Spiegelman, S.R.; Salton, R.B.; Beer, R.W.; Malandra, L.J.; Cognevich, M.L.

    1982-01-01

    A quick-acting stud tensioner apparatus for enabling the loosening or tightening of a stud nut on a reactor vessel stud. The apparatus is adapted to engage the vessel stud by closing a gripper around an upper end of the vessel stud when the apparatus is seated on the stud. Upon lifting the apparatus, the gripper releases the vessel stud so that the apparatus can be removed

  17. Integral Method for the Assessment of U-RANS Effectiveness in Non-Equilibrium Flows and Heat Transfer

    Science.gov (United States)

    Pond, Ian; Edabi, Alireza; Dubief, Yves; White, Christopher

    2015-11-01

    Reynolds Average Navier Stokes (RANS) modeling has established itself as a critical design tool in many engineering applications, thanks to its superior computational efficiency. The drawbacks of RANS models are well known, but not necessarily well understood: poor prediction of transition, non equilibrium flows, mixing and heat transfer, to name the ones relevant to our study. In the present study, we use a DNS of a reciprocating channel flow driven by an oscillating pressure gradient to test several low- and high-Reynolds RANS models. Temperature is introduced as a passive scalar to study heat transfer modeling. Low-Reynolds models manage to capture the overall physics of wall shear and heat flux well, yet with some phase discrepancies, whereas high Reynolds models fail. Under the microscope of the integral method for wall shear and wall heat flux, the qualitative agreement appears more serendipitous than driven by the ability of the models to capture the correct physics. The integral method is shown to be more insightful in the benchmarking of RANS models than the typical comparisons of statistical quantities. The authors acknowledges the support of NSF and DOE under grant NSF/DOE 1258697 (VT) and 1258702 (NH).

  18. Dynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase.

    Science.gov (United States)

    Moss, David K; Wilde, Andrew; Lane, Jon D

    2009-03-01

    During apoptosis, the interphase microtubule network is dismantled then later replaced by a novel, non-centrosomal microtubule array. These microtubules assist in the peripheral redistribution of nuclear fragments in the apoptotic cell; however, the regulation of apoptotic microtubule assembly is not understood. Here, we demonstrate that microtubule assembly depends upon the release of nuclear RanGTP into the apoptotic cytoplasm because this process is blocked in apoptotic cells overexpressing dominant-negative GDP-locked Ran (T24N). Actin-myosin-II contractility provides the impetus for Ran release and, consequently, microtubule assembly is blocked in blebbistatin- and Y27632-treated apoptotic cells. Importantly, the spindle-assembly factor TPX2 (targeting protein for Xklp2), colocalises with apoptotic microtubules, and siRNA silencing of TPX2, but not of the microtubule motors Mklp1 and Kid, abrogates apoptotic microtubule assembly. These data provide a molecular explanation for the assembly of the apoptotic microtubule network, and suggest important similarities with the process of RanGTP- and TPX2-mediated mitotic spindle formation.

  19. Mixture Growth Models of RAN and RAS Row by Row: Insight into the Reading System at Work over Time

    Science.gov (United States)

    Amtmann, Dagmar; Abbott, Robert D.; Berninger, V. W.

    2007-01-01

    Children (n = 122) and adults (n = 200) with dyslexia completed rapid automatic naming (RAN) letters, rapid automatic switching (RAS) letters and numbers, executive function (inhibition, verbal fluency), and phonological working memory tasks. Typically developing 3rd (n = 117) and 5th (n = 103) graders completed the RAS task. Instead of analyzing…

  20. Temperature-sensitive defects of the GSP1gene, yeast Ran homologue, activate the Tel1-dependent pathway

    International Nuclear Information System (INIS)

    Hayashi, Naoyuki; Murakami, Seishi; Tsurusaki, Susumu; Nagaura, Zen-ichiro; Oki, Masaya; Nishitani, Hideo; Kobayashi, Masahiko; Shimizu, Hiroko; Yamamoto, Ken-ichi; Nishimoto, Takeharu

    2007-01-01

    RanGTPase is involved in many cellular processes. It functions in nuclear-cytosolic transport and centrosome formation. Ran also localizes to chromatin as RCC1 does, its guanine nucleotide exchange factor, but Ran's function on chromatin is not known. We found that gsp1, a temperature-sensitive mutant of GSP1, a Saccharomyces cerevisiae Ran homologue, suppressed the hydroxyurea (HU) and ultra violet (UV) sensitivities of the mec1 mutant. In UV-irradiated mec1 gsp1 cells, Rad53 was phosphorylated despite the lack of Mec1. This suppression depended on the TEL1 gene, given that the triple mutant, mec1 gsp1 tel1, was unable to grow. The gsp1 mutations also suppressed the HU sensitivity of the rad9 mutant in a Tel1-dependent manner, but not the HU sensitivity of the rad53 mutant. These results indicated that Rad53 was activated by the Tel1 pathway in mec1 gsp1 cells, suggesting that Gsp1 helps regulate the role switching the ATM family kinases Mec1 and Tel1

  1. Reactor pressure vessel steels

    International Nuclear Information System (INIS)

    Van De Velde, J.; Fabry, A.; Van Walle, E.; Chaouuadi, R.

    1998-01-01

    Research and development activities related to reactor pressure vessel steels during 1997 are reported. The objectives of activities of the Belgian Nuclear Research Centre SCK/CEN in this domain are: (1) to develop enhanced surveillance concepts by applying micromechanics and fracture-toughness tests to small specimens, and by performing damage modelling and microstructure characterization; (2) to demonstrate a methodology on a broad database; (3) to achieve regulatory acceptance and industrial use

  2. Reactor Pressure Vessel Steels

    Energy Technology Data Exchange (ETDEWEB)

    Van de Velde, J.; Fabry, A.; Van Walle, E.; Chaoudi, R

    1998-07-01

    SCK-CEN's R and D programme on Reactor Pressure Vessel (RPV) Steels in performed in support of the RVP integrity assessment. Its main objectives are: (1) to develop enhanced surveillance concepts by applying micromechanics and fracture-toughness tests to small specimens, and by performing damage modelling and microstructure characterization; (2) to demonstrate the applied methodology on a broad database; (3) to achieve regulatory acceptance and industrial use. Progress and achievements in 1999 are reported.

  3. Phenomenological vessel burst investigations

    International Nuclear Information System (INIS)

    Hippelein, K.W.; Julisch, P.; Muz, J.; Schiedermaier, J.

    1985-07-01

    Fourteen burst experiments have been carried out using vessels with circumferential and longitudinal flaws, for investigation of the fracture behaviour, i.e. the time-related fracture opening. The vessels had dimensions (outer diameter x wall thickness = 800 x 47 mm) which correspond to the dimensions of the main coolant piping of a 1300 MW e PWR. The test specimens had been made of the base-safe material 20 MnMoNi 55 and of a special, 22 NiMoCr 37 base alloy. The experimental conditions with regard to pressure and temperature have been chosen so as to correspond to normal operating conditions of a PWR (p∝17.5 MPa, T∝300 0 C), i.e. the flaws have been so dimensioned that failure was to be expected at a pressure of p∝17.5 MPa. As a rule, water has been used as the pressure medium, or in some cases air, in order to influence the time-dependent pressure decrease. Fluid and structural dynamics calculations have also been made. In order to determine the impact of a fast propagating crack on the leak-to-fracture curve, which normally is defined by quasistationary experiments, suitable tests have been made with large-volume, cylindrical vessels (outer diameter x wall thickness x length = 3000 x 21 x 14000 mm) made of the material WSt E 43. The leak-before-fracture criterion has been confirmed. (orig./HP) [de

  4. Blood Vessels in Allotransplantation.

    Science.gov (United States)

    Abrahimi, P; Liu, R; Pober, J S

    2015-07-01

    Human vascularized allografts are perfused through blood vessels composed of cells (endothelium, pericytes, and smooth muscle cells) that remain largely of graft origin and are thus subject to host alloimmune responses. Graft vessels must be healthy to maintain homeostatic functions including control of perfusion, maintenance of permselectivity, prevention of thrombosis, and participation in immune surveillance. Vascular cell injury can cause dysfunction that interferes with these processes. Graft vascular cells can be activated by mediators of innate and adaptive immunity to participate in graft inflammation contributing to both ischemia/reperfusion injury and allograft rejection. Different forms of rejection may affect graft vessels in different ways, ranging from thrombosis and neutrophilic inflammation in hyperacute rejection, to endothelialitis/intimal arteritis and fibrinoid necrosis in acute cell-mediated or antibody-mediated rejection, respectively, and to diffuse luminal stenosis in chronic rejection. While some current therapies targeting the host immune system do affect graft vascular cells, direct targeting of the graft vasculature may create new opportunities for preventing allograft injury and loss. © Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons.

  5. Ionizing radiations and blood vessels

    International Nuclear Information System (INIS)

    Vorob'ev, E.I.; Stepanov, R.P.

    1985-01-01

    Data on phenomenology of radiation-induced changes in blood vessels are systematized and authors' experience is generalized. Modern concepts about processes leading to vessel structure injury after irradiation is critically analyzed. Special attention is paid to reparation and compensation of X-ray vessel injury, consideration of which is not yet sufficiently elucidated in literature

  6. Ionizing radiations and blood vessels

    International Nuclear Information System (INIS)

    Vorob'ev, E.I.; Stepanov, R.P.

    1985-01-01

    Data on phenomeology of radiation changes of blood vessels are systemized and the authors' experience is generalyzed. A critical analysis of modern conceptions on processes resulting in vessel structure damage after irradiation, is given. Special attention is paid to reparation and compensation of radiation injury of vessels

  7. DNS, LES and RANS of turbulent heat transfer in boundary layer with suddenly changing wall thermal conditions

    International Nuclear Information System (INIS)

    Hattori, Hirofumi; Yamada, Shohei; Tanaka, Masahiro; Houra, Tomoya; Nagano, Yasutaka

    2013-01-01

    Highlights: • We study the turbulent boundary layer with heat transfer by DNS. • Turbulent boundary layers with suddenly changing wall thermal conditions are observed. • The detailed turbulent statistics and structures in turbulent thermal boundary layer are discussed. • Turbulence models in LES and RANS are evaluated using DNS results. • LES and RANS are almost in good agreement with DNS results. -- Abstract: The objectives of this study are to investigate a thermal field in a turbulent boundary layer with suddenly changing wall thermal conditions by means of direct numerical simulation (DNS), and to evaluate predictions of a turbulence model in such a thermal field, in which DNS of spatially developing boundary layers with heat transfer can be conducted using the generation of turbulent inflow data as a method. In this study, two types of wall thermal condition are investigated using DNS and predicted by large eddy simulation (LES) and Reynolds-averaged Navier–Stokes equation simulation (RANS). In the first case, the velocity boundary layer only develops in the entrance of simulation, and the flat plate is heated from the halfway point, i.e., the adiabatic wall condition is adopted in the entrance, and the entrance region of thermal field in turbulence is simulated. Then, the thermal boundary layer develops along a constant temperature wall followed by adiabatic wall. In the second case, velocity and thermal boundary layers simultaneously develop, and the wall thermal condition is changed from a constant temperature to an adiabatic wall in the downstream region. DNS results clearly show the statistics and structure of turbulent heat transfer in a constant temperature wall followed by an adiabatic wall. In the first case, the entrance region of thermal field in turbulence can be also observed. Thus, both the development and the entrance regions in thermal fields can be explored, and the effects upstream of the thermal field on the adiabatic region are

  8. Assessment of Reynolds stresses tensor reconstruction methods for synthetic turbulent inflow conditions. Application to hybrid RANS/LES methods

    International Nuclear Information System (INIS)

    Laraufie, Romain; Deck, Sébastien

    2013-01-01

    Highlights: • Present various Reynolds stresses reconstruction methods from a RANS-SA flow field. • Quantify the accuracy of the reconstruction methods for a wide range of Reynolds. • Evaluate the capabilities of the overall process (Reconstruction + SEM). • Provide practical guidelines to realize a streamwise RANS/LES (or WMLES) transition. -- Abstract: Hybrid or zonal RANS/LES approaches are recognized as the most promising way to accurately simulate complex unsteady flows under current computational limitations. One still open issue concerns the transition from a RANS to a LES or WMLES resolution in the stream-wise direction, when near wall turbulence is involved. Turbulence content has then to be prescribed at the transition to prevent from turbulence decay leading to possible flow relaminarization. The present paper aims to propose an efficient way to generate this switch, within the flow, based on a synthetic turbulence inflow condition, named Synthetic Eddy Method (SEM). As the knowledge of the whole Reynolds stresses is often missing, the scope of this paper is focused on generating the quantities required at the SEM inlet from a RANS calculation, namely the first and second order statistics of the aerodynamic field. Three different methods based on two different approaches are presented and their capability to accurately generate the needed aerodynamic values is investigated. Then, the ability of the combination SEM + Reconstruction method to manufacture well-behaved turbulence is demonstrated through spatially developing flat plate turbulent boundary layers. In the mean time, important intrinsic features of the Synthetic Eddy method are pointed out. The necessity of introducing, within the SEM, accurate data, with regards to the outer part of the boundary layer, is illustrated. Finally, user’s guidelines are given depending on the Reynolds number based on the momentum thickness, since one method is suitable for low Reynolds number while the

  9. Nanoformulation of D-α-tocopheryl polyethylene glycol 1000 succinate-b-poly(ε-caprolactone-ran-glycolide) diblock copolymer for breast cancer therapy.

    Science.gov (United States)

    Huang, Laiqiang; Chen, Hongbo; Zheng, Yi; Song, Xiaosong; Liu, Ranyi; Liu, Kexin; Zeng, Xiaowei; Mei, Lin

    2011-10-01

    The purpose of this research was to develop formulation of docetaxel-loaded biodegradable TPGS-b-(PCL-ran-PGA) nanoparticles for breast cancer chemotherapy. A novel diblock copolymer, d-α-tocopheryl polyethylene glycol 1000 succinate-b-poly(ε-caprolactone-ran-glycolide) [TPGS-b-(PCL-ran-PGA)], was synthesized from ε-caprolactone, glycolide and d-α-tocopheryl polyethylene glycol 1000 succinate by ring-opening polymerization using stannous octoate as catalyst. The obtained copolymers were characterized by (1)H NMR, GPC and TGA. The docetaxel-loaded TPGS-b-(PCL-ran-PGA) nanoparticles were prepared and characterized. The data showed that the fluorescence TPGS-b-(PCL-ran-PGA) nanoparticles could be internalized by MCF-7 cells. The TPGS-b-(PCL-ran-PGA) nanoparticles achieved significantly higher level of cytotoxicity than commercial Taxotere®. MCF-7 xenograft tumor model on SCID mice showed that docetaxel formulated in the TPGS-b-(PCL-ran-PGA) nanoparticles could effectively inhibit the growth of tumor over a longer period of time than Taxotere® at the same dose. In conclusion, the TPGS-b-(PCL-ran-PGA) copolymer could be acted as a novel and potential biologically active polymeric material for nanoformulation in breast cancer chemotherapy. This journal is © The Royal Society of Chemistry 2011

  10. RISET STRATEGI IMPLEMENTASI C-RAN DI TELKOMSEL MELALUI KOLABORASI JARINGAN NG-PON2 DI TELKOM AKSES MENGGUNAKAN PENDEKATAN METODE STRATEGIC SITUATION ANALYSIS

    Directory of Open Access Journals (Sweden)

    Tri Susanto

    2007-07-01

    Full Text Available Cloud Radio Access Network (C-RAN adalah teknologi akses radio yang diyakini mampu menekan biaya CAPEX dan OPEX dari mobile operator dan memberikan performansi yang lebih baik dibandingkan Radio Access Network (RAN tradisional. Salah satu faktor kunci sukses implementasi C-RAN adalah penyediaan jaringan fonthaul yang efektif. Tujuan penelitian ini adalah membuat strategi implementasi C-RAN di Telkomsel melalui kolaborasi jaringan NG-PON2 di Telkom Akses. Pada tulisan ini menggunakan metode analisis kualitatif dengan melakukan strategy situation analysis (SSA yaitu melakukan analisa data eksternal maupun internal dan selanjutnya diformulasikan sebagai dasar pembuatan strategi implementasi. Dari penelitian ini dihasilkan usulan strategi implementasi C-RAN di Telkomsel melalui kolaborasi jaringan NG-PON2 di Telkom Akses.

  11. A Game-Theoretical Approach for Spectrum Efficiency Improvement in Cloud-RAN

    Directory of Open Access Journals (Sweden)

    Zhuofu Zhou

    2016-01-01

    Full Text Available As tremendous mobile devices access to the Internet in the future, the cells which can provide high data rate and more capacity are expected to be deployed. Specifically, in the next generation of mobile communication 5G, cloud computing is supposed to be applied to radio access network. In cloud radio access network (Cloud-RAN, the traditional base station is divided into two parts, that is, remote radio heads (RRHs and base band units (BBUs. RRHs are geographically distributed and densely deployed, so as to achieve high data rate and low latency. However, the ultradense deployment inevitably deteriorates spectrum efficiency due to the severer intercell interference among RRHs. In this paper, the downlink spectrum efficiency can be improved through the cooperative transmission based on forming the coalitions of RRHs. We formulate the problem as a coalition formation game in partition form. In the process of coalition formation, each RRH can join or leave one coalition to maximize its own individual utility while taking into account the coalition utility at the same time. Moreover, the convergence and stability of the resulting coalition structure are studied. The numeric simulation result demonstrates that the proposed approach based on coalition formation game is superior to the noncooperative method in terms of the aggregate coalition utility.

  12. İran Halk Kütüphaneleri: Niceliksel Bir Değerlendirme

    Directory of Open Access Journals (Sweden)

    Jahangir Gholipour

    2013-06-01

    Full Text Available Halk kütüphaneleri dijital uçurumun azaltılmasında önemli roller üstlenen toplumsal kuruluşlardır. On­ların, bu rollerini gerçekleştirebilmeleri için niceliksel açıdan yeterli durumda olmaları gerekmektedir. Ayrıca, halk kütüphanelerine ilişkin niceliksel göstergeler niteliklerini ve nitelikli hizmet vermelerini doğrudan belirler. İran, 30 ilde yaşayan 71 milyon nüfusa sahip bir Ortadoğu ülkesidir. Bu çalışmada, İran’daki halk kütüphanelerine ilişkin niceliksel durum kütüphane sayısı, kullanıcı, derme ve personel unsurları açısından ortaya konulmaya çalışılmıştır. Elde edilen sonuçlara göre, İran’da ele alınan söz konusu unsurlar açısından genelde bir yetersizlik olduğu anlaşılmıştır. Çalışma sonunda bazı önerilerde bulunulmuştur.

  13. Reynolds Averaged Navier-Stokes (RANS) equation solutions of wind turbine wakes

    Energy Technology Data Exchange (ETDEWEB)

    Ludwig, Daniel Evandro; Horn, Diego Anderson; Petry, Adriane Prisco [Thermal and Energy Study Group, Mechanical Engeneering Department, Federal University of Rio Grande do Sul, Porto Alegre (Brazil)], E-mail: adrianep@mecanica.ufrgs.br

    2010-07-01

    This paper aims to evaluate the influence of three different turbulence models in the study of a wind turbine wake. Numerical Simulation is used as working tool to characterize the flow through the wind turbines, it is used the numeric simulation. The numerical analysis is based on the finite volume method and the Reynolds Averaged Navier-Stokes (RANS) equations. Three turbulence models are used to represent the total effects of turbulence in the flow: the two equations k-classical and the RNG k- models, based on the turbulent viscosity; and the Shear Stress Transport (SST) model, based on the transport of the Reynolds tensor. The results of the 'u' velocity profiles are compared to experimental data from Vermeer (2003) at distances equivalent to 2, 4, 6, 8, 10 and 16 diameters downstream from the turbine. Results shows that the SST model gives better results until 6 diameters, beyond this distance there is no significant differences between the compared models. (author)

  14. RANS Modeling of Stably Stratified Turbulent Boundary Layer Flows in OpenFOAM®

    Directory of Open Access Journals (Sweden)

    Wilson Jordan M.

    2015-01-01

    Full Text Available Quantifying mixing processes relating to the transport of heat, momentum, and scalar quantities of stably stratified turbulent geophysical flows remains a substantial task. In a stably stratified flow, such as the stable atmospheric boundary layer (SABL, buoyancy forces have a significant impact on the flow characteristics. This study investigates constant and stability-dependent turbulent Prandtl number (Prt formulations linking the turbulent viscosity (νt and diffusivity (κt for modeling applications of boundary layer flows. Numerical simulations of plane Couette flow and pressure-driven channel flow are performed using the Reynolds-averaged Navier-Stokes (RANS framework with the standard k-ε turbulence model. Results are compared with DNS data to evaluate model efficacy for predicting mean velocity and density fields. In channel flow simulations, a Prandtl number formulation for wall-bounded flows is introduced to alleviate overmixing of the mean density field. This research reveals that appropriate specification of Prt can improve predictions of stably stratified turbulent boundary layer flows.

  15. Validation of the simpleFoam (RANS solver for the atmospheric boundary layer in complex terrain

    Directory of Open Access Journals (Sweden)

    Peralta C.

    2014-01-01

    Full Text Available We validate the simpleFoam (RANS solver in OpenFOAM (version 2.1.1 for simulating neutral atmospheric boundary layer flows in complex terrain. Initial and boundary conditions are given using Richards and Hoxey proposal [1]. In order to obtain stable simulation of the ABL, modified wall functions are used to set the near-wall boundary conditions, following Blocken et al remedial measures [2]. A structured grid is generated with the new library terrainBlockMesher [3,4], based on OpenFOAM's blockMesh native mesher. The new tool is capable of adding orographic features and the forest canopy. Additionally, the mesh can be refined in regions with complex orography. We study both the classical benchmark case of Askervein hill [5] and the more recent Bolund island data set [6]. Our purpose is two-folded: to validate the performance of OpenFOAM steady state solvers, and the suitability of the new meshing tool to generate high quality structured meshes, which will be used in the future for performing more computationally intensive LES simulations in complex terrain.

  16. CFD modelling approaches against single wind turbine wake measurements using RANS

    International Nuclear Information System (INIS)

    Stergiannis, N; Lacor, C; Beeck, J V; Donnelly, R

    2016-01-01

    Numerical simulations of two wind turbine generators including the exact geometry of their blades and hub are compared against a simplified actuator disk model (ADM). The wake expansion of the upstream rotor is investigated and compared with measurements. Computational Fluid Dynamics (CFD) simulations have been performed using the open-source platform OpenFOAM [1]. The multiple reference frame (MRF) approach was used to model the inner rotating reference frames in a stationary computational mesh and outer reference frame for the full wind turbine rotor simulations. The standard k — ε and k — ω turbulence closure schemes have been used to solve the steady state, three dimensional Reynolds Averaged Navier- Stokes (RANS) equations. Results of near and far wake regions are compared with wind tunnel measurements along three horizontal lines downstream. The ADM under-predicted the velocity deficit at the wake for both turbulence models. Full wind turbine rotor simulations showed good agreement against the experimental data at the near wake, amplifying the differences between the simplified models. (paper)

  17. Simulating wind and marine hydrokinetic turbines with actuator lines in RANS and LES

    Science.gov (United States)

    Bachant, Peter; Wosnik, Martin

    2015-11-01

    As wind and marine hydrokinetic (MHK) turbine designs mature, focus is shifting towards improving turbine array layouts for maximizing overall power output, i.e., minimizing wake interference for axial-flow or horizontal-axis turbines, or taking advantage of constructive wake interaction for cross-flow or vertical-axis turbines. Towards this goal, an actuator line model (ALM) was developed to provide a computationally feasible method for simulating full turbine arrays inside Navier-Stokes models. The ALM predicts turbine loading with the blade element method combined with sub-models for dynamic stall and flow curvature. The open-source software is written as an extension library for the OpenFOAM CFD package, which allows the ALM body force to be applied to their standard RANS and LES solvers. Turbine forcing is also applied to volume of fluid (VOF) models, e.g., for predicting free surface effects on submerged MHK devices. An additional sub-model is considered for injecting turbulence model scalar quantities based on actuator line element loading. Results are presented for the simulation of performance and wake dynamics of axial- and cross-flow turbines and compared with moderate Reynolds number experiments and body-fitted mesh, blade-resolving CFD. Work supported by NSF-CBET grant 1150797.

  18. COPS5 (Jab1) protein increases β site processing of amyloid precursor protein and amyloid β peptide generation by stabilizing RanBP9 protein levels.

    Science.gov (United States)

    Wang, Hongjie; Dey, Debleena; Carrera, Ivan; Minond, Dmitriy; Bianchi, Elisabetta; Xu, Shaohua; Lakshmana, Madepalli K

    2013-09-13

    Increased processing of amyloid precursor protein (APP) and accumulation of neurotoxic amyloid β peptide (Aβ) in the brain is central to the pathogenesis of Alzheimer's disease (AD). Therefore, the identification of molecules that regulate Aβ generation is crucial for future therapeutic approaches for AD. We demonstrated previously that RanBP9 regulates Aβ generation in a number of cell lines and primary neuronal cultures by forming tripartite protein complexes with APP, low-density lipoprotein-related protein, and BACE1, consequently leading to increased amyloid plaque burden in the brain. RanBP9 is a scaffold protein that exists and functions in multiprotein complexes. To identify other proteins that may bind RanBP9 and regulate Aβ levels, we used a two-hybrid analysis against a human brain cDNA library and identified COPS5 as a novel RanBP9-interacting protein. This interaction was confirmed by coimmunoprecipitation experiments in both neuronal and non-neuronal cells and mouse brain. Colocalization of COPS5 and RanBP9 in the same subcellular compartments further supported the interaction of both proteins. Furthermore, like RanBP9, COPS5 robustly increased Aβ generation, followed by increased soluble APP-β (sAPP-β) and decreased soluble-APP-α (sAPP-α) levels. Most importantly, down-regulation of COPS5 by siRNAs reduced Aβ generation, implying that endogenous COPS5 regulates Aβ generation. Finally, COPS5 levels were increased significantly in AD brains and APΔE9 transgenic mice, and overexpression of COPS5 strongly increased RanBP9 protein levels by increasing its half-life. Taken together, these results suggest that COPS5 increases Aβ generation by increasing RanBP9 levels. Thus, COPS5 is a novel RanBP9-binding protein that increases APP processing and Aβ generation by stabilizing RanBP9 protein levels.

  19. Pressure vessel lid

    International Nuclear Information System (INIS)

    Schoening, J.; Elter, C.; Becker, G.; Pertiller, S.

    1986-01-01

    The invention concerns a lid for closing openings in reactor pressure vessels containing helium, which is made as a circular casting with hollow spaces and a flat floor and is set on the opening and kept down. It consists of helium-tight metal cast material with sufficient temperature resistance. There are at least two concentric heat resistant seals let into the bottom of the lid. The bottom is in immediate contact with the container atmosphere and has hollow spaces in its inside in the area opposite to the opening. (orig./HP) [de

  20. [Small vessel cerebrovascular disease].

    Science.gov (United States)

    Cardona Portela, P; Escrig Avellaneda, A

    2018-05-09

    Small vessel vascular disease is a spectrum of different conditions that includes lacunar infarction, alteration of deep white matter, or microbleeds. Hypertension is the main risk factor, although the atherothrombotic lesion may be present, particularly in large-sized lacunar infarctions along with other vascular risk factors. MRI findings are characteristic and the lesions authentic biomarkers that allow differentiating the value of risk factors and defining their prognostic value. Copyright © 2018 SEH-LELHA. Publicado por Elsevier España, S.L.U. All rights reserved.

  1. An automated vessel segmentation of retinal images using multiscale vesselness

    International Nuclear Information System (INIS)

    Ben Abdallah, M.; Malek, J.; Tourki, R.; Krissian, K.

    2011-01-01

    The ocular fundus image can provide information on pathological changes caused by local ocular diseases and early signs of certain systemic diseases, such as diabetes and hypertension. Automated analysis and interpretation of fundus images has become a necessary and important diagnostic procedure in ophthalmology. The extraction of blood vessels from retinal images is an important and challenging task in medical analysis and diagnosis. In this paper, we introduce an implementation of the anisotropic diffusion which allows reducing the noise and better preserving small structures like vessels in 2D images. A vessel detection filter, based on a multi-scale vesselness function, is then applied to enhance vascular structures.

  2. Evaluation of RANS and LES models for Natural Convection in High-Aspect-Ratio Parallel Plate Channels

    Science.gov (United States)

    Fradeneck, Austen; Kimber, Mark

    2017-11-01

    The present study evaluates the effectiveness of current RANS and LES models in simulating natural convection in high-aspect ratio parallel plate channels. The geometry under consideration is based on a simplification of the coolant and bypass channels in the very high-temperature gas reactor (VHTR). Two thermal conditions are considered, asymmetric and symmetric wall heating with an applied heat flux to match Rayleigh numbers experienced in the VHTR during a loss of flow accident (LOFA). RANS models are compared to analogous high-fidelity LES simulations. Preliminary results demonstrate the efficacy of the low-Reynolds number k- ɛ formulations and their enhancement to the standard form and Reynolds stress transport model in terms of calculating the turbulence production due to buoyancy and overall mean flow variables.

  3. Reduced RAN expression and disrupted transport between cytoplasm and nucleus; a key event in Alzheimer's disease pathophysiology.

    Directory of Open Access Journals (Sweden)

    Diego Mastroeni

    Full Text Available Transcription of DNA is essential for cell maintenance and survival; inappropriate localization of proteins that are involved in transcription would be catastrophic. In Alzheimer's disease brains, and in vitro studies, we have found qualitative and quantitative deficits in transport into the nucleus of DNA methyltransferase 1 (DNMT1 and RNA polymerase II (RNA pol II, accompanied by their abnormal sequestration in the cytoplasm. RAN (RAs-related Nuclear protein knockdown, by siRNA and oligomeric Aβ42 treatment in neurons, replicate human data which indicate that transport disruption in AD may be mechanistically linked to reduced expression of RAN, a pivotal molecule in nucleocytoplasmic transport. In vitro studies also indicate a significant role for oligomeric Aβ42 in the observed phenomena. We propose a model in which reduced transcription regulators in the nucleus and their increased presence in the cytoplasm may lead to many of the cellular manifestations of Alzheimer's disease.

  4. A frequency domain linearized Navier-Stokes method including acoustic damping by eddy viscosity using RANS

    Science.gov (United States)

    Holmberg, Andreas; Kierkegaard, Axel; Weng, Chenyang

    2015-06-01

    In this paper, a method for including damping of acoustic energy in regions of strong turbulence is derived for a linearized Navier-Stokes method in the frequency domain. The proposed method is validated and analyzed in 2D only, although the formulation is fully presented in 3D. The result is applied in a study of the linear interaction between the acoustic and the hydrodynamic field in a 2D T-junction, subject to grazing flow at Mach 0.1. Part of the acoustic energy at the upstream edge of the junction is shed as harmonically oscillating disturbances, which are conveyed across the shear layer over the junction, where they interact with the acoustic field. As the acoustic waves travel in regions of strong shear, there is a need to include the interaction between the background turbulence and the acoustic field. For this purpose, the oscillation of the background turbulence Reynold's stress, due to the acoustic field, is modeled using an eddy Newtonian model assumption. The time averaged flow is first solved for using RANS along with a k-ε turbulence model. The spatially varying turbulent eddy viscosity is then added to the spatially invariant kinematic viscosity in the acoustic set of equations. The response of the 2D T-junction to an incident acoustic field is analyzed via a plane wave scattering matrix model, and the result is compared to experimental data for a T-junction of rectangular ducts. A strong improvement in the agreement between calculation and experimental data is found when the modification proposed in this paper is implemented. Discrepancies remaining are likely due to inaccuracies in the selected turbulence model, which is known to produce large errors e.g. for flows with significant rotation, which the grazing flow across the T-junction certainly is. A natural next step is therefore to test the proposed methodology together with more sophisticated turbulence models.

  5. Targeting Therapy Resistant Tumor Vessels

    Science.gov (United States)

    2008-08-01

    Morris LS. Hysterectomy vs. resectoscopic endometrial ablation for the control of abnormal uterine bleeding . A cost-comparative study. J Reprod Med 1994;39...after the antibody treatment contain a pericyte coat, vessel architecture is normal, the diameter of the vessels is smaller (dilated, abnormal vessels...involvement of proteases from inflammatory mast cells and functionally abnormal (Carmeliet and Jain, 2000; Pasqualini (Coussens et al., 1999) and other bone

  6. The vessel fluence; Fluence cuve

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    This book presents the proceedings of the technical meeting on the reactors vessels fluence. They are grouped in eight sessions: the industrial context and the stakes of the vessels control; the organization and the methodology for the fluence computation; the concerned physical properties; the reference computation methods; the fluence monitoring in an industrial context; vessels monitoring under irradiation; others methods in the world; the research and development programs. (A.L.B.)

  7. The cyst nematode SPRYSEC protein RBP-1 elicits Gpa2- and RanGAP2-dependent plant cell death.

    Directory of Open Access Journals (Sweden)

    Melanie Ann Sacco

    2009-08-01

    Full Text Available Plant NB-LRR proteins confer robust protection against microbes and metazoan parasites by recognizing pathogen-derived avirulence (Avr proteins that are delivered to the host cytoplasm. Microbial Avr proteins usually function as virulence factors in compatible interactions; however, little is known about the types of metazoan proteins recognized by NB-LRR proteins and their relationship with virulence. In this report, we demonstrate that the secreted protein RBP-1 from the potato cyst nematode Globodera pallida elicits defense responses, including cell death typical of a hypersensitive response (HR, through the NB-LRR protein Gpa2. Gp-Rbp-1 variants from G. pallida populations both virulent and avirulent to Gpa2 demonstrated a high degree of polymorphism, with positive selection detected at numerous sites. All Gp-RBP-1 protein variants from an avirulent population were recognized by Gpa2, whereas virulent populations possessed Gp-RBP-1 protein variants both recognized and non-recognized by Gpa2. Recognition of Gp-RBP-1 by Gpa2 correlated to a single amino acid polymorphism at position 187 in the Gp-RBP-1 SPRY domain. Gp-RBP-1 expressed from Potato virus X elicited Gpa2-mediated defenses that required Ran GTPase-activating protein 2 (RanGAP2, a protein known to interact with the Gpa2 N terminus. Tethering RanGAP2 and Gp-RBP-1 variants via fusion proteins resulted in an enhancement of Gpa2-mediated responses. However, activation of Gpa2 was still dependent on the recognition specificity conferred by amino acid 187 and the Gpa2 LRR domain. These results suggest a two-tiered process wherein RanGAP2 mediates an initial interaction with pathogen-delivered Gp-RBP-1 proteins but where the Gpa2 LRR determines which of these interactions will be productive.

  8. CFD RANS Simulations on a Generic Conventional Scale Model Submarine: Comparison between Fluent and OpenFOAM

    Science.gov (United States)

    2015-09-01

    UNCLASSIFIED UNCLASSIFIED CFD RANS Simulations on a Generic Conventional Scale Model Submarine: Comparison between Fluent and OpenFOAM ... OpenFOAM to replace some of the Fluent simulations. The fidelity of the Fluent code has been carefully validated, but the accuracy of parts of the... OpenFOAM code have not been so extensively tested. To test the accuracy of the OpenFOAM software, CFD simulations have been performed on the DSTO

  9. Americium behaviour in plastic vessels

    International Nuclear Information System (INIS)

    Legarda, F.; Herranz, M.; Idoeta, R.; Abelairas, A.

    2010-01-01

    The adsorption of 241 Am dissolved in water in different plastic storage vessels was determined. Three different plastics were investigated with natural and distilled waters and the retention of 241 Am by these plastics was studied. The same was done by varying vessel agitation time, vessel agitation speed, surface/volume ratio of water in the vessels and water pH. Adsorptions were measured to be between 0% and 70%. The adsorption of 241 Am is minimized with no water agitation, with PET or PVC plastics, and by water acidification.

  10. Americium behaviour in plastic vessels

    Energy Technology Data Exchange (ETDEWEB)

    Legarda, F.; Herranz, M. [Departamento de Ingenieria Nuclear y Mecanica de Fluidos, Escuela Tecnica Superior de Ingenieria de Bilbao, Universidad del Pais Vasco (UPV/EHU), Alameda de Urquijo s/n, 48013 Bilbao (Spain); Idoeta, R., E-mail: raquel.idoeta@ehu.e [Departamento de Ingenieria Nuclear y Mecanica de Fluidos, Escuela Tecnica Superior de Ingenieria de Bilbao, Universidad del Pais Vasco (UPV/EHU), Alameda de Urquijo s/n, 48013 Bilbao (Spain); Abelairas, A. [Departamento de Ingenieria Nuclear y Mecanica de Fluidos, Escuela Tecnica Superior de Ingenieria de Bilbao, Universidad del Pais Vasco (UPV/EHU), Alameda de Urquijo s/n, 48013 Bilbao (Spain)

    2010-07-15

    The adsorption of {sup 241}Am dissolved in water in different plastic storage vessels was determined. Three different plastics were investigated with natural and distilled waters and the retention of {sup 241}Am by these plastics was studied. The same was done by varying vessel agitation time, vessel agitation speed, surface/volume ratio of water in the vessels and water pH. Adsorptions were measured to be between 0% and 70%. The adsorption of {sup 241}Am is minimized with no water agitation, with PET or PVC plastics, and by water acidification.

  11. Americium behaviour in plastic vessels.

    Science.gov (United States)

    Legarda, F; Herranz, M; Idoeta, R; Abelairas, A

    2010-01-01

    The adsorption of (241)Am dissolved in water in different plastic storage vessels was determined. Three different plastics were investigated with natural and distilled waters and the retention of (241)Am by these plastics was studied. The same was done by varying vessel agitation time, vessel agitation speed, surface/volume ratio of water in the vessels and water pH. Adsorptions were measured to be between 0% and 70%. The adsorption of (241)Am is minimized with no water agitation, with PET or PVC plastics, and by water acidification. Copyright 2009 Elsevier Ltd. All rights reserved.

  12. [Large vessel vasculitides].

    Science.gov (United States)

    Morović-Vergles, Jadranka; Puksić, Silva; Gracanin, Ana Gudelj

    2013-01-01

    Large vessel vasculitis includes Giant cell arteritis and Takayasu arteritis. Giant cell arteritis is the most common form of vasculitis affect patients aged 50 years or over. The diagnosis should be considered in older patients who present with new onset of headache, visual disturbance, polymyalgia rheumatica and/or fever unknown cause. Glucocorticoides remain the cornerstone of therapy. Takayasu arteritis is a chronic panarteritis of the aorta ant its major branches presenting commonly in young ages. Although all large arteries can be affected, the aorta, subclavian and carotid arteries are most commonly involved. The most common symptoms included upper extremity claudication, hypertension, pain over the carotid arteries (carotidynia), dizziness and visual disturbances. Early diagnosis and treatment has improved the outcome in patients with TA.

  13. Reactor pressure vessel embrittlement

    International Nuclear Information System (INIS)

    1992-07-01

    Within the framework of the IAEA extrabudgetary programme on the Safety of WWER-440/230 NPPs, a list of safety issues requiring broad studies of generic interest have been agreed upon by an Advisory Group who met in Vienna in September 1990. The list was later revised in the light of the programme findings. The information on the status of the issues, and on the amount of work already completed and under way in the various countries, needs to be compiled. Moreover, an evaluation of what further work is required to resolve each one of the issues is also necessary. In view of this, the IAEA has started the preparation of a series of status reports on the various issues. This report on the generic safety issue ''Reactor Pressure Vessel Embrittlement'' presents a comprehensive survey of technical information available in the field and identifies those aspects which require further investigation. 39 refs, 21 figs, 4 tabs

  14. Reactor containment vessel

    International Nuclear Information System (INIS)

    Ochiai, Kanehiro; Hayagumo, Sunao; Morikawa, Matsuo.

    1981-01-01

    Purpose: To safety and simplify the structure in a reactor containment vessel. Constitution: Steam flow channels with steam jetting ports communicating to coolants are provided between a communication channel and coolants in a pressure suppression chamber. Upon loss of coolant accidents, pressure in a dry well will increase, then force downwards water in an annulus portion and further flow out the water through steam jetting ports into a suppression pool. Thus, the steam flow channel is filled with steams or airs present in the dry well, which are released through the steam jetting ports into the pressure suppression chamber. Even though water is violently vibrated owing to the upward movement of air bubbles and condensation of steam bubbles, the annular portion and the steam jetting ports are filled with steams or the like, direct dynamic loads onto the structures such as communication channels can be avoided. (J.P.N.)

  15. A Priori Analysis of a Compressible Flamelet Model using RANS Data for a Dual-Mode Scramjet Combustor

    Science.gov (United States)

    Quinlan, Jesse R.; Drozda, Tomasz G.; McDaniel, James C.; Lacaze, Guilhem; Oefelein, Joseph

    2015-01-01

    In an effort to make large eddy simulation of hydrocarbon-fueled scramjet combustors more computationally accessible using realistic chemical reaction mechanisms, a compressible flamelet/progress variable (FPV) model was proposed that extends current FPV model formulations to high-speed, compressible flows. Development of this model relied on observations garnered from an a priori analysis of the Reynolds-Averaged Navier-Stokes (RANS) data obtained for the Hypersonic International Flight Research and Experimentation (HI-FiRE) dual-mode scramjet combustor. The RANS data were obtained using a reduced chemical mechanism for the combustion of a JP-7 surrogate and were validated using avail- able experimental data. These RANS data were then post-processed to obtain, in an a priori fashion, the scalar fields corresponding to an FPV-based modeling approach. In the current work, in addition to the proposed compressible flamelet model, a standard incompressible FPV model was also considered. Several candidate progress variables were investigated for their ability to recover static temperature and major and minor product species. The effects of pressure and temperature on the tabulated progress variable source term were characterized, and model coupling terms embedded in the Reynolds- averaged Navier-Stokes equations were studied. Finally, results for the novel compressible flamelet/progress variable model were presented to demonstrate the improvement attained by modeling the effects of pressure and flamelet boundary conditions on the combustion.

  16. Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis

    Science.gov (United States)

    Kim, Dong-Hyun; Kwon, Sanghoon; Byun, Sangwon; Xiao, Zhen; Park, Sean; Wu, Shwu-Yuan; Chiang, Cheng-Ming; Kemper, Byron; Kemper, Jongsook Kim

    2016-01-01

    Bile acids (BAs) are recently recognized signalling molecules that profoundly affect metabolism. Because of detergent-like toxicity, BA levels must be tightly regulated. An orphan nuclear receptor, Small Heterodimer Partner (SHP), plays a key role in this regulation, but how SHP senses the BA signal for feedback transcriptional responses is not clearly understood. We show an unexpected function of a nucleoporin, RanBP2, in maintaining BA homoeostasis through SUMOylation of SHP. Upon BA signalling, RanBP2 co-localizes with SHP at the nuclear envelope region and mediates SUMO2 modification at K68, which facilitates nuclear transport of SHP and its interaction with repressive histone modifiers to inhibit BA synthetic genes. Mice expressing a SUMO-defective K68R SHP mutant have increased liver BA levels, and upon BA- or drug-induced biliary insults, these mice exhibit exacerbated cholestatic pathologies. These results demonstrate a function of RanBP2-mediated SUMOylation of SHP in maintaining BA homoeostasis and protecting from the BA hepatotoxicity. PMID:27412403

  17. Accuracy of the actuator disc-RANS approach for predicting the performance and wake of tidal turbines.

    Science.gov (United States)

    Batten, W M J; Harrison, M E; Bahaj, A S

    2013-02-28

    The actuator disc-RANS model has widely been used in wind and tidal energy to predict the wake of a horizontal axis turbine. The model is appropriate where large-scale effects of the turbine on a flow are of interest, for example, when considering environmental impacts, or arrays of devices. The accuracy of the model for modelling the wake of tidal stream turbines has not been demonstrated, and flow predictions presented in the literature for similar modelled scenarios vary significantly. This paper compares the results of the actuator disc-RANS model, where the turbine forces have been derived using a blade-element approach, to experimental data measured in the wake of a scaled turbine. It also compares the results with those of a simpler uniform actuator disc model. The comparisons show that the model is accurate and can predict up to 94 per cent of the variation in the experimental velocity data measured on the centreline of the wake, therefore demonstrating that the actuator disc-RANS model is an accurate approach for modelling a turbine wake, and a conservative approach to predict performance and loads. It can therefore be applied to similar scenarios with confidence.

  18. Pressure vessel for nuclear reactors

    International Nuclear Information System (INIS)

    1975-01-01

    The invention applies to a pressure vessel for nuclear reactors whose shell, made of cast metal segments, has a steel liner. This liner must be constructed to withstand all operational stresses and to be easily repairable. The invention solves this problem by installing the liner at a certain distance from the inner wall of the pressure vessel shell and by filling this clearance with supporting concrete. Both the concrete and the steel liner must have a lower prestress than the pressure vessel shell. In order to avoid damage to the liner when prestressing the pressure vessel shell, special connecting elements are provided which consist of welded-on fastening elements projecting into recesses in the cast metal segments of the pressure vessel. Their design is described in detail. (TK) [de

  19. I RAN Fast and I Remembered What I Read: The Relationship between Reading, Rapid Automatic Naming, and Auditory and Visual Short-Term Memory

    Directory of Open Access Journals (Sweden)

    Sheila G. Crewther

    2011-05-01

    Full Text Available Although rapid automatic naming (RAN speed and short-term auditory memory are widely recognised as good predictors of reading ability in most age groups, the predictive value of short-term memory for visually presented digits for reading and RAN in young typically developing learner readers (mean age 91.5 months has seldom been investigated. We found that visual digit span is a better predictor of reading ability than auditory digit span in learner readers. A significant correlation has also been found between RAN speed and visual, but not auditory digit span. These results suggests that RAN speed may be a good predictor of a child's future reading ability and eventual fluency because like visual digit span, it is a measure of rate of access to memory for the visual icons and their semantic name and meaning. The results also suggest that auditory memory is not an important factor in young children learning to read.

  20. Containment vessel stability analysis

    International Nuclear Information System (INIS)

    Harstead, G.A.; Morris, N.F.; Unsal, A.I.

    1983-01-01

    The stability analysis for a steel containment shell is presented herein. The containment is a freestanding shell consisting of a vertical cylinder with a hemispherical dome. It is stiffened by large ring stiffeners and relatively small longitudinal stiffeners. The containment vessel is subjected to both static and dynamic loads which can cause buckling. These loads must be combined prior to their use in a stability analysis. The buckling loads were computed with the aid of the ASME Code case N-284 used in conjunction with general purpose computer codes and in-house programs. The equations contained in the Code case were used to compute the knockdown factors due to shell imperfections. After these knockdown factors were applied to the critical stress states determined by freezing the maximum dynamic stresses and combining them with other static stresses, a linear bifurcation analysis was carried out with the aid of the BOSOR4 program. Since the containment shell contained large penetrations, the Code case had to be supplemented by a local buckling analysis of the shell area surrounding the largest penetration. This analysis was carried out with the aid of the NASTRAN program. Although the factor of safety against buckling obtained in this analysis was satisfactory, it is claimed that the use of the Code case knockdown factors are unduly conservative when applied to the analysis of buckling around penetrations. (orig.)

  1. Pressure vessel design

    International Nuclear Information System (INIS)

    Annaratone, D.

    2007-01-01

    This book guides through general and fundamental problems of pressure vessel design. It moreover considers problems which seem to be of lower importance but which turn out to be crucial in the design phase. The basic approach is rigorously scientific with a complete theoretical development of the topics treated, but the analysis is always pushed so far as to offer concrete and precise calculation criteria that can be immediately applied to actual designs. This is accomplished through appropriate algorithms that lead to final equations or to characteristic parameters defined through mathematical equations. The first chapter describes how to achieve verification criteria, the second analyzes a few general problems, such as stresses of the membrane in revolution solids and edge effects. The third chapter deals with cylinders under pressure from the inside, while the fourth focuses on cylinders under pressure from the outside. The fifth chapter covers spheres, and the sixth is about all types of heads. Chapter seven discusses different components of particular shape as well as pipes, with special attention to flanges. The eighth chapter discusses the influence of holes, while the ninth is devoted to the influence of supports. Finally, chapter ten illustrates the fundamental criteria regarding fatigue analysis. Besides the unique approach to the entire work, original contributions can be found in most chapters, thanks to the author's numerous publications on the topic and to studies performed ad hoc for this book. (orig.)

  2. Volvo ja Ikea endine tegevjuht Göran Carstedt : Tänapäevane (personali)juhtimine peab sisaldama eeskätt looduslähedast mõtteviisi / Göran Carstedt ; interv. Tiina Saar

    Index Scriptorium Estoniae

    Carstedt, Göran

    2008-01-01

    Juhtimiskonsultant ning Organisatsioonilise Õppimise Ühingu eestvedaja ja arendaja Göran Carsedt vastab küsimustele, mis puudutavad ettevõtte tegevust personali tööle pühendumise parendamiseks, ettevõtte jätkusuutlikku juhtimist ja tootlikkust, majanduslanguse mõju ettevõtete personalipoliitikale, talendijuhtimist, väikeste ettevõttete ellujäämist majanduslanguse ajal, IKEA kui hea tööandja mainet ning jätkusuutlikku personaliarendajat. Lisa: Jätkusuutlik juhtimine Rootsi moodi

  3. Saccharomyces cerevisiae GTPase complex: Gtr1p-Gtr2p regulates cell-proliferation through Saccharomyces cerevisiae Ran-binding protein, Yrb2p

    International Nuclear Information System (INIS)

    Wang Yonggang; Nakashima, Nobutaka; Sekiguchi, Takeshi; Nishimoto, Takeharu

    2005-01-01

    A Gtr1p GTPase, the GDP mutant of which suppresses both temperature-sensitive mutants of Saccharomyces cerevisiae RanGEF/Prp20p and RanGAP/Rna1p, was presently found to interact with Yrb2p, the S. cerevisiae homologue of mammalian Ran-binding protein 3. Gtr1p bound the Ran-binding domain of Yrb2p. In contrast, Gtr2p, a partner of Gtr1p, did not bind Yrb2p, although it bound Gtr1p. A triple mutant: yrb2Δ gtr1Δ gtr2Δ was lethal, while a double mutant: gtr1Δ gtr2Δ survived well, indicating that Yrb2p protected cells from the killing effect of gtr1Δ gtr2Δ. Recombinant Gtr1p and Gtr2p were purified as a complex from Escherichia coli. The resulting Gtr1p-Gtr2p complex was comprised of an equal amount of Gtr1p and Gtr2p, which inhibited the Rna1p/Yrb2 dependent RanGAP activity. Thus, the Gtr1p-Gtr2p cycle was suggested to regulate the Ran cycle through Yrb2p

  4. Formation of a Trimeric Xpo1-Ran[GTP]-Ded1 Exportin Complex Modulates ATPase and Helicase Activities of Ded1.

    Directory of Open Access Journals (Sweden)

    Glenn Hauk

    Full Text Available The DEAD-box RNA helicase Ded1, which is essential in yeast and known as DDX3 in humans, shuttles between the nucleus and cytoplasm and takes part in several basic processes including RNA processing and translation. A key interacting partner of Ded1 is the exportin Xpo1, which together with the GTP-bound state of the small GTPase Ran, facilitates unidirectional transport of Ded1 out of the nucleus. Here we demonstrate that Xpo1 and Ran[GTP] together reduce the RNA-stimulated ATPase and helicase activities of Ded1. Binding and inhibition of Ded1 by Xpo1 depend on the affinity of the Ded1 nuclear export sequence (NES for Xpo1 and the presence of Ran[GTP]. Association with Xpo1/Ran[GTP] reduces RNA-stimulated ATPase activity of Ded1 by increasing the apparent KM for the RNA substrate. Despite the increased KM, the Ded1:Xpo1:Ran[GTP] ternary complex retains the ability to bind single stranded RNA, suggesting that Xpo1/Ran[GTP] may modulate the substrate specificity of Ded1. These results demonstrate that, in addition to transport, exportins such as Xpo1 also have the capability to alter enzymatic activities of their cargo.

  5. PWR vessel flaw distribution development

    International Nuclear Information System (INIS)

    Rosinski, S.T.; Kennedy, E.L.; Foulds, J.R.; Kinsman, K.M.

    1990-01-01

    This paper reports on PWR pressure vessels which operate under NRC rules and regulatory guides intended to prevent failure of the vessels. Plants failing to meet the operating criteria specified under these rules and regulations are required to analytically demonstrate fitness for service in order to continue operation. The initial flaw size or distribution of initial vessel flaws is a key input to the required vessel integrity analyses. However, the flaw distribution assumed in the development of the NRC Regulations and recommended for the plant specific analyses is potentially over-conservative. This is because the distribution is based on the limited amount of vessel inspection data available at the time the criteria were being developed and does not take full advantage of the more recent and reliable domestic vessel inspection results. The U.S. Department of Energy is funding an effort through Sandia National Laboratories to investigate the possibility of developing a new flaw distribution based on the increased amount and improved reliability of domestic vessel inspection data. Results of Phase I of the program indicate that state-of-the-art NDE systems' capabilities are sufficient for development of a new flaw distribution that could ultimately provide life extension benefits over the presently required operating practice

  6. Nuclear reactor vessel decontamination systems

    International Nuclear Information System (INIS)

    McGuire, P. J.

    1985-01-01

    There is disclosed in the present application, a decontamination system for reactor vessels. The system is operatable without entry by personnel into the contaminated vessel before the decontamination operation is carried out and comprises an assembly which is introduced into the vertical cylindrical vessel of the typical boiling water reactor through the open top. The assembly includes a circular track which is centered by guideways permanently installed in the reactor vessel and the track guides opposed pairs of nozzles through which water under very high pressure is directed at the wall for progressively cutting and sweeping a tenacious radioactive coating as the nozzles are driven around the track in close proximity to the vessel wall. The whole assembly is hoisted to a level above the top of the vessel by a crane, outboard slides on the assembly brought into engagement with the permanent guideways and the assembly progressively lowered in the vessel as the decontamination operation progresses. The assembly also includes a low pressure nozzle which forms a spray umbrella above the high pressure nozzles to contain radioactive particles dislodged during the decontamination

  7. Gammatography of thick lead vessels

    International Nuclear Information System (INIS)

    Raghunath, V.M.; Bhatnagar, P.K.; Sundaram, V.M.

    1979-01-01

    Radiography, scintillation and GM counting and dose measurements using ionisation chamber equipment are commonly used for detecting flaws/voids in materials. The first method is mostly used for steel vessels and to a lesser extent thin lead vessels also and is essentially qualitative. Dose measuring techniques are used for very thick and large lead vessels for which high strength radioactive sources are required, with its inherent handling problems. For vessels of intermediate thicknesses, it is ideal to use a small strength source and a GM or scintillation counter assembly. At the Reactor Research Centre, Kalpakkam, such a system was used for checking three lead vessels of thicknesses varying from 38mm to 65mm. The tolerances specified were +- 4% variation in lead thickness. The measurements also revealed the non concentricity of one vessel which had a thickness varying from 38mm to 44mm. The second vessel was patently non-concentric and the dimensional variation was truly reproduced in the measurements. A third vessel was fabricated with careful control of dimensions and the measurements exhibited good concentricity. Small deviations were observed, attributable to imperfect bondings between steel and lead. This technique has the following advantages: (a) weaker sources used result in less handling problems reducing the personnel exposures considerably; (b) the sensitivity of the instrument is quite good because of better statistics; (c) the time required for scanning a small vessel is more, but a judicious use of a scintillometer for initial fast scan will help in reducing the total scanning time; (d) this method can take advantage of the dimensional variations themselves to get the calibration and to estimate the deviations from specified tolerances. (auth.)

  8. BY FRUSTUM CONFINING VESSEL

    Directory of Open Access Journals (Sweden)

    Javad Khazaei

    2016-09-01

    Full Text Available Helical piles are environmentally friendly and economical deep foundations that, due to environmental considerations, are excellent additions to a variety of deep foundation alternatives available to the practitioner. Helical piles performance depends on soil properties, the pile geometry and soil-pile interaction. Helical piles can be a proper alternative in sensitive environmental sites if their bearing capacity is sufficient to support applied loads. The failure capacity of helical piles in this study was measured via an experimental research program that was carried out by Frustum Confining Vessel (FCV. FCV is a frustum chamber by approximately linear increase in vertical and lateral stresses along depth from top to bottom. Due to special geometry and applied bottom pressure, this apparatus is a proper choice to test small model piles which can simulate field stress conditions. Small scale helical piles are made with either single helix or more helixes and installed in fine grained sand with three various densities. Axial loading tests including compression and tension tests were performed to achieve pile ultimate capacity. The results indicate the helical piles behavior depends essentially on pile geometric characteristics, i.e. helix configuration and soil properties. According to the achievements, axial uplift capacity of helical model piles is about equal to usual steel model piles that have the helixes diameter. Helical pile compression bearing capacity is too sufficient to act as a medium pile, thus it can be substituted other piles in special geoenvironmental conditions. The bearing capacity also depends on spacing ratio, S/D, and helixes diameter.

  9. Vacuum vessel for thermonuclear device

    International Nuclear Information System (INIS)

    Hagiwara, Koji; Imura, Yasuya.

    1979-01-01

    Purpose: To provide constituted method for easily performing baking of vacuum vessel, using short-circuiting segments. Constitution: At the time of baking, one turn circuit is formed by the vacuum vessel and short-circuiting segments, and current transformer converting the one turn circuit into a secondary circuit by the primary coil and iron core is formed, and the vacuum vessel is Joule heated by an induction current from the primary coil. After completion of baking, the short-circuiting segments are removed. (Kamimura, M.)

  10. PWR vessel inspection performance improvements

    International Nuclear Information System (INIS)

    Blair Fairbrother, D.; Bodson, Francis

    1998-01-01

    A compact robot for ultrasonic inspection of reactor vessels has been developed that reduces setup logistics and schedule time for mandatory code inspections. Rather than installing a large structure to access the entire weld inspection area from its flange attachment, the compact robot examines welds in overlapping patches from a suction cup anchor to the shell wall. The compact robot size allows two robots to be operated in the vessel simultaneously. This significantly reduces the time required to complete the inspection. Experience to date indicates that time for vessel examinations can be reduced to fewer than four days. (author)

  11. The proliferation marker pKi-67 organizes the nucleolus during the cell cycle depending on Ran and cyclin B.

    Science.gov (United States)

    Schmidt, Mirko H H; Broll, Rainer; Bruch, Hans-Peter; Bögler, Oliver; Duchrow, Michael

    2003-01-01

    The proliferation marker pKi-67 ('Ki-67 antigen') is commonly used in clinical and research pathology to detect proliferating cells, as it is only expressed during cell-cycle progression. Despite the fact that this antigen has been known for nearly two decades, there is still no adequate understanding of its function. This study has therefore identified proteins that interact with pKi-67, using a yeast two-hybrid system. A mammalian two-hybrid system and immunoprecipitation studies were used to verify these interactions. Among other cell-cycle regulatory proteins, two binding partners associated with the small GTPase Ran were identified. In addition, DNA-structural and nucleolus-associated proteins binding to pKi-67 were found. Moreover, it was demonstrated that the N-terminal domain of pKi-67 is capable of self-binding to its own repeat region encoded by exon 13. Since RanBP, a protein involved in the transport of macromolecules over the nuclear lamina, was found to be a binding partner, a possible effect of pKi-67 on the localization of cell-cycle regulatory proteins was proposed. To test this hypothesis, a tetracycline-responsive gene expression system was used to induce the pKi-67 fragments previously used for the two-hybrid screens in HeLa cells. Subsequent immunostaining revealed the translocation of cyclin B1 from cytoplasm to nucleoli in response to this expression. It is suggested that pKi-67 is a Ran-associated protein with a role in the disintegration and reformation of the nucleolus and thereby in entry into and exit from the M-phase. Copyright 2002 John Wiley & Sons, Ltd.

  12. Special enclosure for a pressure vessel

    International Nuclear Information System (INIS)

    Wedellsborg, B.W.; Wedellsborg, U.W.

    1993-01-01

    A pressure vessel enclosure is described comprising a primary pressure vessel, a first pressure vessel containment assembly adapted to enclose said primary pressure vessel and be spaced apart therefrom, a first upper pressure vessel jacket adapted to enclose the upper half of said first pressure vessel containment assembly and be spaced apart therefrom, said upper pressure vessel jacket having an upper rim and a lower rim, each of said rims connected in a slidable relationship to the outer surface of said first pressure vessel containment assembly, mean for connecting in a sealable relationship said upper rim of said first upper pressure vessel jacket to the outer surface of said first pressure vessel containment assembly, means for connecting in a sealable relationship said lower rim of said first upper pressure vessel jacket to the outer surface of said first pressure vessel containment assembly, a first lower pressure vessel jacket adapted to enclose the lower half of said first pressure vessel containment assembly and be spaced apart therefrom, said lower pressure vessel jacket having an upper rim connected in a slidable relationship to the outer surface of said first pressure vessel containment assembly, and means for connecting in a sealable relationship said upper rim of said first lower pressure vessel jacket to the outer surface of said first pressure vessel containment assembly, a second upper pressure vessel jacket adapted to enclose said first upper pressure vessel jacket and be spaced apart therefrom, said second upper pressure vessel jacket having an upper rim and a lower rim, each of said rims adapted to slidably engage the outer surface of said first upper pressure vessel jacket, means for sealing said rims, a second lower pressure vessel jacket adapted to enclose said first lower pressure vessel jacket and be spaced apart therefrom

  13. Extending the bounds of ‘steady’ RANS closures: Toward an instability-sensitive Reynolds stress model

    International Nuclear Information System (INIS)

    Jakirlić, S.; Maduta, R.

    2015-01-01

    Highlights: • A grid-spacing free, instability-sensitive Reynolds stress model is formulated. • The model is capable of capturing turbulence fluctuations. • Substantial improvement concerning proper turbulence activity enhancement is achieved. • The model is intensively validated in a series of 2D and 3D separating flows. • The model feasibility is also checked in some attached flows. - Abstract: The incapability of the conventional Unsteady RANS (Reynolds–Averaged Navier Stokes) models to adequately capture turbulence unsteadiness presents the prime motivation of the present work, which focuses on formulating an instability-sensitive, eddy-resolving turbulence model on the Second-Moment Closure level. The model scheme adopted, functioning as a ‘sub-scale’ model in the Unsteady RANS framework, represents a differential near-wall Reynolds stress model formulated in conjunction with the scale-supplying equation governing the homogeneous part of the inverse turbulent time scale ω h (ω h = ε h /k). The latter equation was straightforwardly obtained from the model equation describing the dynamics of the homogeneous part of the total viscous dissipation rate ε, defined as ε h = ε − 0.5ν∂ 2 k/(∂x j ∂x j ) (Jakirlic and Hanjalic, 2002), by applying the derivation rules to the expression for ω h . The model capability to account for vortex length and time scales variability was enabled through an additional term in the corresponding length-scale determining equation, providing a selective enhancement of its production, pertinent particularly to the highly unsteady separated shear layer region, modeled in terms of the von Karman length scale (comprising the second derivative of the velocity field) in line with the SAS (Scale-Adaptive Simulation) proposal (Menter and Egorov, 2010). The present model formulation, termed as SRANS model (Sensitized RANS), does not comprise any parameter depending explicitly on grid spacing. The predictive

  14. 2013 West Coast Vessel Tracklines

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  15. 2011 West Coast Vessel Tracklines

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  16. 2013 Great Lakes Vessel Tracklines

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  17. 2011 Great Lakes Vessel Tracklines

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  18. 2011 East Coast Vessel Tracklines

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  19. Coastal Discard Logbook Survey (Vessels)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains data on the type and amount of marine resources that are discarded or interacted with by vessels that are selected to report to the Southeast...

  20. SC/OQ Vessel Database

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Data tables holding information for the Surf Clam/Ocean Quahog vessel and dealer/processor logbooks (negative and positive), as well as individual tag information...

  1. Vessel Permit System Data Set

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — GARFO issues federal fishing permits annually to owners of fishing vessels who fish in the Greater Atlantic region, as required by federal regulation. These permits...

  2. Reactor pressure vessel status report

    International Nuclear Information System (INIS)

    Strosnider, J.; Wichman, K.; Elliot, B.

    1994-12-01

    This report gives a brief description of the reactor pressure vessel (RPV), followed by a discussion of the radiation embrittlement of RPV beltline materials and the two indicators for measuring embrittlement, the end-of-license (EOL) reference temperature and the EOL upper-shelf energy. It also summarizes the GL 92-01 effort and presents, for all 37 boiling water reactor plants and 74 pressurized water reactor plants in the United States, the current status of compliance with regulatory requirements related to ensuring RPV integrity. The staff has evaluated the material data needed to predict neutron embrittlement of the reactor vessel beltline materials. These data will be stored in a computer database entitled the reactor vessel integrity database (RVID). This database will be updated annually to reflect the changes made by the licensees in future submittals and will be used by the NRC staff to assess the issues related to vessel structural integrity

  3. Reactor-vessel-sectioning demonstration

    International Nuclear Information System (INIS)

    Lundgren, R.A.

    1981-07-01

    A successful technical demonstration of simulated reactor vessel sectioning was completed using the combined techniques of air arc gouging and flame cutting. A 4-ft x 3-ft x 9-in. thick sample was fabricated of A36 carbon steel to simulate a reactor vessel wall. A 1/4-in layer of stainless steel (SS) was tungsten inert gas (TIG)-welded to the carbon steel. Several techniques were considered to section the simulated reactor vessel: an air arc gouger was chosen to penetrate the stainless steel, and flame cutting was selected to sever the carbon steel. After the simulated vessel was successfully cut from the SS side, another cut was made, starting from the carbon steel side. This cut was also successful. Cutting from the carbon steel side has the advantages of cost reduction since the air arc gouging step is eliminated and contamination controlled because the molten metal is blown inward

  4. Power reactor pressure vessel benchmarks

    International Nuclear Information System (INIS)

    Rahn, F.J.

    1978-01-01

    A review is given of the current status of experimental and calculational benchmarks for use in understanding the radiation embrittlement effects in the pressure vessels of operating light water power reactors. The requirements of such benchmarks for application to pressure vessel dosimetry are stated. Recent developments in active and passive neutron detectors sensitive in the ranges of importance to embrittlement studies are summarized and recommendations for improvements in the benchmark are made. (author)

  5. Prosopomorphic vessels from Moesia Superior

    Directory of Open Access Journals (Sweden)

    Nikolić Snežana

    2008-01-01

    Full Text Available The prosopomorphic vessels from Moesia Superior had the form of beakers varying in outline but similar in size. They were wheel-thrown, mould-made or manufactured by using a combination of wheel-throwing and mould-made appliqués. Given that face vessels are considerably scarcer than other kinds of pottery, more than fifty finds from Moesia Superior make an enviable collection. In this and other provinces face vessels have been recovered from military camps, civilian settlements and necropolises, which suggests that they served more than one purpose. It is generally accepted that the faces-masks gave a protective role to the vessels, be it to protect the deceased or the family, their house and possessions. More than forty of all known finds from Moesia Superior come from Viminacium, a half of that number from necropolises. Although tangible evidence is lacking, there must have been several local workshops producing face vessels. The number and technological characteristics of the discovered vessels suggest that one of the workshops is likely to have been at Viminacium, an important pottery-making centre in the second and third centuries.

  6. Vacuum vessel for thermonuclear device

    International Nuclear Information System (INIS)

    Kikuchi, Mitsuru; Kurita, Gen-ichi; Onozuka, Masaki; Suzuki, Masaru.

    1997-01-01

    Heat of inner walls of a vacuum vessel that receive radiation heat from plasmas by way of first walls is removed by a cooling medium flowing in channels for cooling the inner walls. Nuclear heat generation of constitutional materials of the vacuum vessel caused by fast neutrons and γ rays is removed by a cooling medium flowing in cooling channels disposed in the vacuum vessel. Since the heat from plasmas and the nuclear heat generation are removed separately, the amount of the cooling medium flowing in the channels for cooling inner walls is increased for cooling a great amount of heat from plasmas while the amount of the cooling medium flowing in the channels for cooling the inside of the vacuum vessel is reduced for cooling the small amount of nuclear heat generation. Since the amount of the cooling medium can thus be optimized, the capacity of the facilities for circulating the cooling medium can be reduced. In addition, since the channels for cooling the inner walls and the channels of cooling medium formed in the vacuum vessel are disposed to the inner walls of the vacuum vessel on the side opposite to plasmas, integrity of the channels relative to leakage of the cooling medium can be ensured. (N.H.)

  7. Vacuum vessel for thermonuclear device

    Energy Technology Data Exchange (ETDEWEB)

    Kikuchi, Mitsuru; Kurita, Gen-ichi [Japan Atomic Energy Research Inst., Tokyo (Japan); Onozuka, Masaki; Suzuki, Masaru

    1997-07-31

    Heat of inner walls of a vacuum vessel that receive radiation heat from plasmas by way of first walls is removed by a cooling medium flowing in channels for cooling the inner walls. Nuclear heat generation of constitutional materials of the vacuum vessel caused by fast neutrons and {gamma} rays is removed by a cooling medium flowing in cooling channels disposed in the vacuum vessel. Since the heat from plasmas and the nuclear heat generation are removed separately, the amount of the cooling medium flowing in the channels for cooling inner walls is increased for cooling a great amount of heat from plasmas while the amount of the cooling medium flowing in the channels for cooling the inside of the vacuum vessel is reduced for cooling the small amount of nuclear heat generation. Since the amount of the cooling medium can thus be optimized, the capacity of the facilities for circulating the cooling medium can be reduced. In addition, since the channels for cooling the inner walls and the channels of cooling medium formed in the vacuum vessel are disposed to the inner walls of the vacuum vessel on the side opposite to plasmas, integrity of the channels relative to leakage of the cooling medium can be ensured. (N.H.)

  8. LES and RANS modeling of pulverized coal combustion in swirl burner for air and oxy-combustion technologies

    International Nuclear Information System (INIS)

    Warzecha, Piotr; Boguslawski, Andrzej

    2014-01-01

    Combustion of pulverized coal in oxy-combustion technology is one of the effective ways to reduce the emission of greenhouse gases into the atmosphere. The process of transition from conventional combustion in air to the oxy-combustion technology, however, requires a thorough investigations of the phenomena occurring during the combustion process, that can be greatly supported by numerical modeling. The paper presents the results of numerical simulations of pulverized coal combustion process in swirl burner using RANS (Reynolds-averaged Navier–Stokes equations) and LES (large Eddy simulation) methods for turbulent flow. Numerical simulations have been performed for the oxyfuel test facility located at the Institute of Heat and Mass Transfer at RWTH Aachen University. Detailed analysis of the flow field inside the combustion chamber for cold flow and for the flow with combustion using different numerical methods for turbulent flows have been done. Comparison of the air and oxy-coal combustion process for pulverized coal shows significant differences in temperature, especially close to the burner exit. Additionally the influence of the combustion model on the results has been shown for oxy-combustion test case. - Highlights: • Oxy-coal combustion has been modeled for test facility operating at low oxygen ratio. • Coal combustion process has been modeled with simplified combustion models. • Comparison of oxy and air combustion process of pulverized coal has been done. • RANS (Reynolds-averaged Navier–Stokes equations) and LES (large Eddy simulation) results for pulverized coal combustion process have been compared

  9. Potential involvement of drought-induced Ran GTPase CLRan1 in root growth enhancement in a xerophyte wild watermelon.

    Science.gov (United States)

    Akashi, Kinya; Yoshimura, Kazuya; Kajikawa, Masataka; Hanada, Kouhei; Kosaka, Rina; Kato, Atsushi; Katoh, Akira; Nanasato, Yoshihiko; Tsujimoto, Hisashi; Yokota, Akiho

    2016-10-01

    Enhanced root growth is known as the survival strategy of plants under drought. Previous proteome analysis in drought-resistant wild watermelon has shown that Ran GTPase, an essential regulator of cell division and proliferation, was induced in the roots under drought. In this study, two cDNAs were isolated from wild watermelon, CLRan1 and CLRan2, which showed a high degree of structural similarity with those of other plant Ran GTPases. Quantitative RT-PCR and promoter-GUS assays suggested that CLRan1 was expressed mainly in the root apex and lateral root primordia, whereas CLRan2 was more broadly expressed in other part of the roots. Immunoblotting analysis confirmed that the abundance of CLRan proteins was elevated in the root apex region under drought stress. Transgenic Arabidopsis overexpressing CLRan1 showed enhanced primary root growth, and the growth was maintained under osmotic stress, indicating that CLRan1 functions as a positive factor for maintaining root growth under stress conditions.

  10. Automated method for identification and artery-venous classification of vessel trees in retinal vessel networks.

    Science.gov (United States)

    Joshi, Vinayak S; Reinhardt, Joseph M; Garvin, Mona K; Abramoff, Michael D

    2014-01-01

    The separation of the retinal vessel network into distinct arterial and venous vessel trees is of high interest. We propose an automated method for identification and separation of retinal vessel trees in a retinal color image by converting a vessel segmentation image into a vessel segment map and identifying the individual vessel trees by graph search. Orientation, width, and intensity of each vessel segment are utilized to find the optimal graph of vessel segments. The separated vessel trees are labeled as primary vessel or branches. We utilize the separated vessel trees for arterial-venous (AV) classification, based on the color properties of the vessels in each tree graph. We applied our approach to a dataset of 50 fundus images from 50 subjects. The proposed method resulted in an accuracy of 91.44% correctly classified vessel pixels as either artery or vein. The accuracy of correctly classified major vessel segments was 96.42%.

  11. The TPX vacuum vessel and in-vessel components

    International Nuclear Information System (INIS)

    Heitzenroeder, P.; Bialek, J.; Ellis, R.; Kessel, C.; Liew, S.

    1994-01-01

    The Tokamak Physics Experiment (TPX) is a superconducting tokamak with double-null diverters. TPX is designed for 1,000-second discharges with the capability of being upgraded to steady state operation. High neutron yields resulting from the long duration discharges require that special consideration be given to materials and maintainability. A unique feature of the TPX is the use of a low activation, titanium alloy vacuum vessel. Double-wall vessel construction is used since it offers an efficient solution for shielding, bakeout and cooling. Contained within the vacuum vessel are the passive coil system, Plasma Facing Components (PFCs), magnetic diagnostics, and the internal control coils. All PFCs utilize carbon-carbon composites for exposed surfaces

  12. Clay Corner: Recreating Chinese Bronze Vessels.

    Science.gov (United States)

    Gamble, Harriet

    1998-01-01

    Presents a lesson where students make faux Chinese bronze vessels through slab or coil clay construction after they learn about the history, function, and design of these vessels. Utilizes a variety of glaze finishes in order to give the vessels an aged look. Gives detailed guidelines for creating the vessels. (CMK)

  13. SUMO modification through rapamycin-mediated heterodimerization reveals a dual role for Ubc9 in targeting RanGAP1 to nuclear pore complexes

    International Nuclear Information System (INIS)

    Zhu Shanshan; Zhang Hong; Matunis, Michael J.

    2006-01-01

    SUMOs (small ubiquitin-related modifiers) are eukaryotic proteins that are covalently conjugated to other proteins and thereby regulate a wide range of important cellular processes. The molecular mechanisms by which SUMO modification influences the functions of most target proteins and cellular processes, however, remain poorly defined. A major obstacle to investigating the effects of SUMO modification is the availability of a system for selectively inducing the modification or demodification of an individual protein. To address this problem, we have developed a procedure using the rapamycin heterodimerizer system. This procedure involves co-expression of rapamycin-binding domain fusion proteins of SUMO and candidate SUMO substrates in living cells. Treating cells with rapamycin induces a tight association between SUMO and a single SUMO substrate, thereby allowing specific downstream effects to be analyzed. Using RanGAP1 as a model SUMO substrate, the heterodimerizer system was used to investigate the molecular mechanism by which SUMO modification targets RanGAP1 from the cytoplasm to nuclear pore complexes (NPCs). Our results revealed a dual role for Ubc9 in targeting RanGAP1 to NPCs: In addition to conjugating SUMO-1 to RanGAP1, Ubc9 is also required to form a stable ternary complex with SUMO-1 modified RanGAP1 and Nup358. As illustrated by our studies, the rapamycin heterodimerizer system represents a novel tool for studying the molecular effects of SUMO modification

  14. An investigation into the reduction of log-layer mismatch in wall-modeled LES with a hybrid RANS/LES approach

    Science.gov (United States)

    Balin, Riccardo; Spalart, Philippe R.; Jansen, Kenneth E.

    2017-11-01

    Hybrid RANS/LES modeling approaches used in the context of wall-modeled LES (WMLES) of channel flows and boundary layers often suffer from a mismatch in the RANS and LES log-layer intercepts of the mean velocity profile. In the vicinity of the interface between the RANS and LES regions, the mean velocity gradient is too steep causing a departure from the log-law, an over-prediction of the velocity in the outer layer and an under-prediction of the skin-friction. This steep gradient is attributed to inadequate modeled Reynolds stresses in the upper portion of the RANS layer and at the interface. Channel flow computations were carried out with the IDDES approach of Shur et al. in WMLES mode based on the Spalart-Allmaras RANS model. This talk investigates the robustness of this approach for unstructured grids and explores changes required for grids where insufficient elevation of the Reynolds stresses is observed. Awards of computer time were provided by Innovative and Novel Computational Impact on Theory and Experiment (INCITE) and Early Science programs. Resources of the Argonne Leadership Computing Facility, a DOE Office of Science User Facility, were used.

  15. Vacuum vessel for thermonuclear device

    International Nuclear Information System (INIS)

    Kikuchi, Mitsuru; Nagashima, Keisuke; Suzuki, Masaru; Onozuka, Masaki.

    1997-01-01

    A vacuum vessel main body and structural members at the inside and the outside of the vacuum vessel main body are constituted by structural materials activated by irradiation of neutrons from plasmas such as stainless steels. Shielding members comprising tungsten or molybdenum are disposed on the surface of the vacuum vessel main body and the structural members of the inside and the outside of the main body. The shielding members have a function also as first walls or a seat member for the first walls. Armor tiles may be disposed to the shielding members. The shielding members and the armor tiles are secured to a securing seat member disposed, for example, to an inner plate of the vacuum vessel main body by bolts. Since the shielding members are disposed, it is not necessary to constitute the vacuum vessel main body and the structural members at the inside and the outside thereof by using a low activation material which is less activated, such as a titanium alloy. (I.N.)

  16. Vacuum vessel for thermonuclear device

    Energy Technology Data Exchange (ETDEWEB)

    Kikuchi, Mitsuru; Nagashima, Keisuke [Japan Atomic Energy Research Inst., Tokyo (Japan); Suzuki, Masaru; Onozuka, Masaki

    1997-07-11

    A vacuum vessel main body and structural members at the inside and the outside of the vacuum vessel main body are constituted by structural materials activated by irradiation of neutrons from plasmas such as stainless steels. Shielding members comprising tungsten or molybdenum are disposed on the surface of the vacuum vessel main body and the structural members of the inside and the outside of the main body. The shielding members have a function also as first walls or a seat member for the first walls. Armor tiles may be disposed to the shielding members. The shielding members and the armor tiles are secured to a securing seat member disposed, for example, to an inner plate of the vacuum vessel main body by bolts. Since the shielding members are disposed, it is not necessary to constitute the vacuum vessel main body and the structural members at the inside and the outside thereof by using a low activation material which is less activated, such as a titanium alloy. (I.N.)

  17. Molten material-containing vessel

    International Nuclear Information System (INIS)

    Akagawa, Katsuhiko

    1998-01-01

    The molten material-containing vessel of the present invention comprises a vessel main body having an entrance opened at the upper end, a lid for closing the entrance, an outer tube having an upper end disposed at the lower surface of the lid, extended downwardly and having an closed lower end and an inner tube disposed coaxially with the outer tube. When a molten material is charged from the entrance to the inside of the vessel main body of the molten material-containing vessel and the entrance is closed by the lid, the outer tube and the inner tube are buried in the molten material in the vessel main body, accordingly, a fluid having its temperature elevated by absorption of the heat of the molten material rises along the inner circumferential surface of the outer tube, abuts against the lower surface of the lid and cooled by exchanging heat with the lid and forms a circulating flow. Since the heat in the molten material is continuously absorbed by the fluid, transferred to the lid and released from the lid to the atmospheric air, heat releasing efficiency can be improved compared with conventional cases. (N.H.)

  18. A Comparison of Hybrid Reynolds Averaged Navier Stokes/Large Eddy Simulation (RANS/LES) and Unsteady RANS Predictions of Separated Flow for a Variable Speed Power Turbine Blade Operating with Low Inlet Turbulence Levels

    Science.gov (United States)

    2017-10-01

    6 4 3 passage 4 passage 5 passage 3 Sta. 0 Sta. 2 −2.0 0.0 −55.5°m etal −1.0 y  pitch β 1= 34. 2 ° z ero i β1=−11.8°max i β1=−2.5° t-o β 1 =4 0.0...structured grids at 2 flow conditions, cruise and takeoff, of the VSPT blade. Computations were run in parallel on a Department of Defense...to predict the separation/reattachment suggested by experiment. The difference in results between the 2 grids for RANS computations suggests that

  19. Emergency venting of pressure vessels

    International Nuclear Information System (INIS)

    Steinkamp, H.

    1995-01-01

    With the numerical codes developed for safety analysis the venting of steam vessel can be simulated. ATHLET especially is able to predict the void fraction depending on the vessel height. Although these codes contain a one-dimensional model they allow the description of complex geometries due to the detailed nodalization of the considered apparatus. In chemical reactors, however, the venting process is not only influenced by the flashing behaviour but additionally by the running chemical reaction in the vessel. Therefore the codes used for modelling have to consider the kinetics of the chemical reaction. Further multi-component systems and dissolving processes have to be regarded. In order to preduct the fluid- and thermodynamic process it could be helpful to use 3-dimensional codes in combination with the one-dimensional codes as used in nuclear industry to get a more detailed describtion of the running processes. (orig./HP)

  20. Development of Catamaran Fishing Vessel

    Directory of Open Access Journals (Sweden)

    A. Jamaluddin

    2010-11-01

    Full Text Available Multihull due to a couple of advantages has been the topic of extensive research work in naval architecture. In this study, a series of investigation of fishing vessel to save fuel energy was carried out at ITS. Two types of ship models, monohull (round bilge and hard chine and catamaran, a boat with two hulls (symmetrical and asymmetrical were developed. Four models were produced physically and numerically, tested (towing tank and simulated numerically (CFD code. The results of the two approaches indicated that the catamaran mode might have drag (resistance smaller than those of monohull at the same displacement. A layout of catamaran fishing vessel, proposed here, indicates the freedom of setting the deck equipments for fishing vessel.

  1. A Mobility Management Using Follow-Me Cloud-Cloudlet in Fog-Computing-Based RANs for Smart Cities.

    Science.gov (United States)

    Chen, Yuh-Shyan; Tsai, Yi-Ting

    2018-02-06

    Mobility management for supporting the location tracking and location-based service (LBS) is an important issue of smart city by providing the means for the smooth transportation of people and goods. The mobility is useful to contribute the innovation in both public and private transportation infrastructures for smart cities. With the assistance of edge/fog computing, this paper presents a fully new mobility management using the proposed follow-me cloud-cloudlet (FMCL) approach in fog-computing-based radio access networks (Fog-RANs) for smart cities. The proposed follow-me cloud-cloudlet approach is an integration strategy of follow-me cloud (FMC) and follow-me edge (FME) (or called cloudlet). A user equipment (UE) receives the data, transmitted from original cloud, into the original edge cloud before the handover operation. After the handover operation, an UE searches for a new cloud, called as a migrated cloud, and a new edge cloud, called as a migrated edge cloud near to UE, where the remaining data is migrated from the original cloud to the migrated cloud and all the remaining data are received in the new edge cloud. Existing FMC results do not have the property of the VM migration between cloudlets for the purpose of reducing the transmission latency, and existing FME results do not keep the property of the service migration between data centers for reducing the transmission latency. Our proposed FMCL approach can simultaneously keep the VM migration between cloudlets and service migration between data centers to significantly reduce the transmission latency. The new proposed mobility management using FMCL approach aims to reduce the total transmission time if some data packets are pre-scheduled and pre-stored into the cache of cloudlet if UE is switching from the previous Fog-RAN to the serving Fog-RAN. To illustrate the performance achievement, the mathematical analysis and simulation results are examined in terms of the total transmission time, the

  2. A Mobility Management Using Follow-Me Cloud-Cloudlet in Fog-Computing-Based RANs for Smart Cities

    Directory of Open Access Journals (Sweden)

    Yuh-Shyan Chen

    2018-02-01

    Full Text Available Mobility management for supporting the location tracking and location-based service (LBS is an important issue of smart city by providing the means for the smooth transportation of people and goods. The mobility is useful to contribute the innovation in both public and private transportation infrastructures for smart cities. With the assistance of edge/fog computing, this paper presents a fully new mobility management using the proposed follow-me cloud-cloudlet (FMCL approach in fog-computing-based radio access networks (Fog-RANs for smart cities. The proposed follow-me cloud-cloudlet approach is an integration strategy of follow-me cloud (FMC and follow-me edge (FME (or called cloudlet. A user equipment (UE receives the data, transmitted from original cloud, into the original edge cloud before the handover operation. After the handover operation, an UE searches for a new cloud, called as a migrated cloud, and a new edge cloud, called as a migrated edge cloud near to UE, where the remaining data is migrated from the original cloud to the migrated cloud and all the remaining data are received in the new edge cloud. Existing FMC results do not have the property of the VM migration between cloudlets for the purpose of reducing the transmission latency, and existing FME results do not keep the property of the service migration between data centers for reducing the transmission latency. Our proposed FMCL approach can simultaneously keep the VM migration between cloudlets and service migration between data centers to significantly reduce the transmission latency. The new proposed mobility management using FMCL approach aims to reduce the total transmission time if some data packets are pre-scheduled and pre-stored into the cache of cloudlet if UE is switching from the previous Fog-RAN to the serving Fog-RAN. To illustrate the performance achievement, the mathematical analysis and simulation results are examined in terms of the total transmission time

  3. 33 CFR 90.3 - Pushing vessel and vessel being pushed: Composite unit.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Pushing vessel and vessel being... HOMELAND SECURITY INLAND NAVIGATION RULES INLAND RULES: INTERPRETATIVE RULES § 90.3 Pushing vessel and vessel being pushed: Composite unit. Rule 24(b) of the Inland Rules states that when a pushing vessel and...

  4. 33 CFR 82.3 - Pushing vessel and vessel being pushed: Composite unit.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Pushing vessel and vessel being... HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES 72 COLREGS: INTERPRETATIVE RULES § 82.3 Pushing vessel and vessel being pushed: Composite unit. Rule 24(b) of the 72 COLREGS states that when a pushing vessel and a...

  5. Containment vessel design and practice

    International Nuclear Information System (INIS)

    Bangash, Y.

    1983-01-01

    The state of the art of analysis and design of the concrete containment vessels required for BWR and PWR is reviewed. A step-by-step critical appraisal of the existing work is given. Elastic, inelastic and cracking conditions under extreme loads are fully discussed. Problems associated with these structures are highlighted. A three-dimensional finite element analysis is included to cater for service, overload and dynamic cracking of such structures. Missile impact and seismic effects are included in this work. The second analysis is known as the limit state analysis, which is given to design such vessels for any kind of load. (U.K.)

  6. Stress analysis of pressure vessels

    International Nuclear Information System (INIS)

    Kim, B.K.; Song, D.H.; Son, K.H.; Kim, K.S.; Park, K.B.; Song, H.K.; So, J.Y.

    1979-01-01

    This interim report contains the results of the effort to establish the stress report preparation capability under the research project ''Stress analysis of pressure vessels.'' 1978 was the first year in this effort to lay the foundation through the acquisition of SAP V structural analysis code and a graphic terminal system for improved efficiency of using such code. Software programming work was developed in pre- and post processing, such as graphic presentation of input FEM mesh geometry and output deformation or mode shope patterns, which was proven to be useful when using the FEM computer code. Also, a scheme to apply fracture mechanics concept was developed in fatigue analysis of pressure vessels. (author)

  7. Vessel dilatation in coronary angiograms

    International Nuclear Information System (INIS)

    Hinterauer, L.; Goebel, N.

    1983-01-01

    Amongst 166 patients with aneurysms, ectasia or megaloarteries shown on coronary angiograms, 86.1% had dilated vessels as part of generalised coronary sclerosis (usually in patients with three-vessel disease). In 9%, dilatation was of iatrogenic origin and in 4.8% it was idiopathic. One patient had Marfan's syndrome. Amongst 9 000 patients, there were eight with megalo-arteries without stenosis; six of these had atypical angina and three suffered an infarct. Patients with definite dilatation of the coronary artery and stagnation of contrast flow required treatment. (orig.) [de

  8. Vessel dilatation in coronary angiograms

    Energy Technology Data Exchange (ETDEWEB)

    Hinterauer, L.; Goebel, N.

    1983-11-01

    Amongst 166 patients with aneurysms, ectasia or megaloarteries shown on coronary angiograms, 86.1% had dilated vessels as part of generalised coronary sclerosis (usually in patients with three-vessel disease). In 9%, dilatation was of iatrogenic origin and in 4.8% it was idiopathic. One patient had Marfan's syndrome. Amongst 9 000 patients, there were eight with megalo-arteries without stenosis; six of these had atypical angina and three suffered an infarct. Patients with definite dilatation of the coronary artery and stagnation of contrast flow required treatment.

  9. In vivo FRET imaging revealed a regulatory role of RanGTP in kinetochore-microtubule attachments via Aurora B kinase.

    Directory of Open Access Journals (Sweden)

    Yoke-Peng Lee

    Full Text Available Under the fluctuating circumstances provided by the innate dynamics of microtubules and opposing tensions resulted from microtubule-associated motors, it is vital to ensure stable kinetochore-microtubule attachments for accurate segregation. However, a comprehensive understanding of how this regulation is mechanistically achieved remains elusive. Using our newly designed live cell FRET time-lapse imaging, we found that post-metaphase RanGTP is crucial in the maintenance of stable kinetochore-microtubule attachments by regulating Aurora B kinase via the NES-bearing Mst1. More importantly, our study demonstrates that by ensuring stable alignment of metaphase chromosomes prior to segregation, RanGTP is indispensible in governing the genomic integrity and the fidelity of cell cycle progression. Our findings suggest an additional role of RanGTP beyond its known function in mitotic spindle assembly during the prometaphase-metaphase transition.

  10. A rapid and low noise switch from RANS to WMLES on curvilinear grids with compressible flow solvers

    Science.gov (United States)

    Deck, Sébastien; Weiss, Pierre-Elie; Renard, Nicolas

    2018-06-01

    A turbulent inflow for a rapid and low noise switch from RANS to Wall-Modelled LES on curvilinear grids with compressible flow solvers is presented. It can be embedded within the computational domain in practical applications with WMLES grids around three-dimensional geometries in a flexible zonal hybrid RANS/LES modelling context. It relies on a physics-motivated combination of Zonal Detached Eddy Simulation (ZDES) as the WMLES technique together with a Dynamic Forcing method processing the fluctuations caused by a Zonal Immersed Boundary Condition describing roughness elements. The performance in generating a physically-sound turbulent flow field with the proper mean skin friction and turbulent profiles after a short relaxation length is equivalent to more common inflow methods thanks to the generation of large-scale streamwise vorticity by the roughness elements. Comparisons in a low Mach-number zero-pressure-gradient flat-plate turbulent boundary layer up to Reθ = 6 100 reveal that the pressure field is dominated by the spurious noise caused by the synthetic turbulence methods (Synthetic Eddy Method and White Noise injection), contrary to the new low-noise approach which may be used to obtain the low-frequency component of wall pressure and reproduce its intermittent nature. The robustness of the method is tested in the flow around a three-element airfoil with WMLES in the upper boundary layer near the trailing edge of the main element. In spite of the very short relaxation distance allowed, self-sustainable resolved turbulence is generated in the outer layer with significantly less spurious noise than with the approach involving White Noise. The ZDES grid count for this latter test case is more than two orders of magnitude lower than the Wall-Resolved LES requirement and a unique mesh is involved, which is much simpler than some multiple-mesh strategies devised for WMLES or turbulent inflow.

  11. Book Review: A History of the Czechoslovak Ocean Shipping Company, 1948–1989: How a Small, Landlocked Country Ran Maritime Business During the Cold War

    DEFF Research Database (Denmark)

    Taudal Poulsen, René

    2016-01-01

    Review of: Lenka Krátká: A History of the Czechoslovak Ocean Shipping Company, 1948–1989: How a Small, Landlocked Country Ran Maritime Business During the Cold War. Stuttgart: Ibidem Verlag, 2015. x + 271 pp., tables, notes, bibliography. ISBN: 978-3-8382-0666-0, £23.90 (pbk).......Review of: Lenka Krátká: A History of the Czechoslovak Ocean Shipping Company, 1948–1989: How a Small, Landlocked Country Ran Maritime Business During the Cold War. Stuttgart: Ibidem Verlag, 2015. x + 271 pp., tables, notes, bibliography. ISBN: 978-3-8382-0666-0, £23.90 (pbk)....

  12. Grounding Damage to Conventional Vessels

    DEFF Research Database (Denmark)

    Lützen, Marie; Simonsen, Bo Cerup

    2003-01-01

    The present paper is concerned with rational design of conventional vessels with regard to bottom damage generated in grounding accidents. The aim of the work described here is to improve the design basis, primarily through analysis of new statistical data for grounding damage. The current regula...

  13. PLANNING VESSEL BODY SECTION PRODUCTION

    Directory of Open Access Journals (Sweden)

    A. G. Grivachevsky

    2015-01-01

    Full Text Available A problem of planning production of a vessel body section is considered. The problem is reduced to the classic Johnson’s tree-machine flow-shop scheduling problem. A genetic algorithm and computer experiment to compare efficiency of this algorithm and the algorithm of full enumeration are described.

  14. Pressure vessel and method therefor

    Science.gov (United States)

    Saunders, Timothy

    2017-09-05

    A pressure vessel includes a pump having a passage that extends between an inlet and an outlet. A duct at the pump outlet includes at least one dimension that is adjustable to facilitate forming a dynamic seal that limits backflow of gas through the passage.

  15. Commercial Passenger Fishing Vessel Fishery

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains the logbook data from U.S.A. Commercial Passenger Fishing Vessels (CPFV) fishing in the U.S.A. EEZ and in waters off of Baja California, from...

  16. Development of PWR pressure vessel steels

    International Nuclear Information System (INIS)

    Druce, S.; Edwards, B.

    1982-01-01

    Requirements to be met by vessel steels for pressurized water reactors are analyzed. Chemicat composition of low-alloyed steels, mechanical properties of sheets and forgings made of these steels and changes in the composition and properties over the wall thickness of the reactor vessel are presented. Problems of the vessel manufacturing including welding and heat treatment processes of sheets and forgings are considered. Special attention is paid to steel embrittlement during vessel fabrication and operation (radiation embrittlement, thermal embrittlement). The role of non-metal inclusions and their effect on anisotropy of fracture toughness is discussed. Possible developments of vessel steels and procedures for producing reactor vessels are reviewed

  17. Development of PWR pressure vessel steels

    Energy Technology Data Exchange (ETDEWEB)

    Druce, S.; Edwards, B.

    1982-01-01

    Requirements to be met by vessel steels for pressurized water reactors are analyzed. Chemicat composition of low-alloyed steels, mechanical properties of sheets and forgings made of these steels and changes in the composition and properties over the wall thickness of the reactor vessel are presented. Problems of the vessel manufacturing including welding and heat treatment processes of sheets and forgings are considered. Special attention is paid to steel embrittlement during vessel fabrication and operation (radiation embrittlement, thermal embrittlement). The role of non-metal inclusions and their effect on anisotropy of fracture toughness is discussed. Possible developments of vessel steels and procedures for producing reactor vessels are reviewed.

  18. Pressure vessel for nuclear reactor plant consisting of several pre-stressed cast pressure vessels

    International Nuclear Information System (INIS)

    Bodmann, E.

    1984-01-01

    Several cylindrical pressure vessel components made of pressure castings are arranged on a sector of a circle around the cylindrical cast pressure vessel for accommodating the helium cooled HTR. Each component pressure vessel is connected to the reactor vessel by a horizontal gas duct. The contact surfaces between reactor and component pressure vessel are in one plane. In the spaces between the individual component pressure vessels, there are supporting blocks made of cast iron, which are hollow and also have flat surfaces. With the reactor vessel and the component pressure vessels they form a disc-shaped connecting part below and above the gas ducts. (orig./PW)

  19. AFSC/FMA/Vessel Assessment Logging

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Vessels fishing trawl gear, vessels fishing hook-and-line and pot gear that are also greater than 57.5 feet overall, and shoreside and floating processing facilities...

  20. 2013 EPA Vessels General Permit (VGP)

    Data.gov (United States)

    U.S. Environmental Protection Agency — Information for any vessel that submitted a Notice of Intent (NOI), Notice of Termination (NOT), or annual report under EPA's 2013 Vessel General Permit (VGP)....

  1. Polydopamine-Functionalized CA-(PCL-ran-PLA) Nanoparticles for Target Delivery of Docetaxel and Chemo-photothermal Therapy of Breast Cancer

    Science.gov (United States)

    Kong, Na; Deng, Mei; Sun, Xiu-Na; Chen, Yi-Ding; Sui, Xin-Bing

    2018-01-01

    Current limitations of cancer therapy include the lack of effective strategy for target delivery of chemotherapeutic drugs, and the difficulty of achieving significant efficacy by single treatment. Herein, we reported a synergistic chemo-photothermal strategy based on aptamer (Apt)-polydopamine (pD) functionalized CA-(PCL-ran-PLA) nanoparticles (NPs) for effective delivery of docetaxel (DTX) and enhanced therapeutic effect. The developed DTX-loaded Apt-pD-CA-(PCL-ran-PLA) NPs achieved promising advantages, such as (i) improved drug loading content (LC) and encapsulation efficiency (EE) initiated by star-shaped copolymer CA-(PCL-ran-PLA); (ii) effective target delivery of drugs to tumor sites by incorporating AS1411 aptamers; (iii) significant therapeutic efficacy caused by synergistic chemo-photothermal treatment. In addition, the pD coating strategy with simple procedures could address the contradiction between targeting modification and maintaining formerly excellent bio-properties. Therefore, with excellent bio-properties and simple preparation procedures, the DTX-loaded Apt-pD-CA-(PCL-ran-PLA) NPs effectively increased the local drug concentration in tumor sites, minimized side effects, and significantly eliminated tumors, indicating the promising application of these NPs for cancer therapy. PMID:29527167

  2. A lentiviral sponge for miR-101 regulates RanBP9 expression and amyloid precursor protein metabolism in hippocampal neurons

    Directory of Open Access Journals (Sweden)

    Christian eBarbato

    2014-02-01

    Full Text Available Neurodegeneration associated with amyloid β (Aβ peptide accumulation, synaptic loss, and memory impairment are pathophysiological features of Alzheimer's disease (AD. Numerous microRNAs regulate amyloid precursor protein (APP expression and metabolism. We previously reported that miR-101 is a negative regulator of APP expression in cultured hippocampal neurons. In this study, a search for predicted APP metabolism-associated miR-101 targets led to the identification of a conserved miR-101 binding site within the 3’ untranslated region (UTR of the mRNA encoding Ran-binding protein 9 (RanBP9. RanBP9 increases APP processing by β-amyloid converting enzyme 1 (BACE1, secretion of soluble APPβ (sAPPβ, and generation of Aβ. MiR-101 significantly reduced reporter gene expression when co-transfected with a RanBP9 3'-UTR reporter construct, while site-directed mutagenesis of the predicted miR-101 target site eliminated the reporter response. To investigate the effect of stable inhibition of miR-101 both in vitro and in vivo, a microRNA sponge was developed to bind miR-101 and derepress its targets. Four tandem bulged miR-101 responsive elements (REs, located downstream of the enhanced green fluorescence protein (EGFP open reading frame and driven by the synapsin promoter, were placed in a lentiviral vector to create the pLSyn-miR-101 sponge. Delivery of the sponge to primary hippocampal neurons significantly increased both APP and RanBP9 expression, as well as sAPPβ levels in the conditioned medium. Importantly, silencing of endogenous RanBP9 reduced sAPPβ levels in miR-101 sponge-containing hippocampal cultures, indicating that miR-101 inhibition may increase amyloidogenic processing of APP by RanBP9. Lastly, the impact of miR-101 on its targets was demonstrated in vivo by intrahippocampal injection of the pLSyn-miR-101 sponge into C57BL6 mice. This study thus provides the basis for studying the consequences of long-term miR-101 inhibition on

  3. Interstitial Cells of Blood Vessels

    Directory of Open Access Journals (Sweden)

    Vladimír Pucovský

    2010-01-01

    Full Text Available Blood vessels are made up of several distinct cell types. Although it was originally thought that the tunica media of blood vessels was composed of a homogeneous population of fully differentiated smooth muscle cells, more recent data suggest the existence of multiple smooth muscle cell subpopulations in the vascular wall. One of the cell types contributing to this heterogeneity is the novel, irregularly shaped, noncontractile cell with thin processes, termed interstitial cell, found in the tunica media of both veins and arteries. While the principal role of interstitial cells in veins seems to be pacemaking, the role of arterial interstitial cells is less clear. This review summarises the knowledge of the functional and structural properties of vascular interstitial cells accumulated so far, offers hypotheses on their physiological role, and proposes directions for future research.

  4. The Vessel Schedule Recovery Problem

    DEFF Research Database (Denmark)

    Brouer, Berit Dangaard; Plum, Christian Edinger Munk; Vaaben, Bo

    Maritime transportation is the backbone of world trade and is accountable for around 3% of the worlds CO2 emissions. We present the Vessel Schedule Recovery Problem (VSRP) to evaluate a given disruption scenario and to select a recovery action balancing the trade off between increased bunker cons...... consumption and the impact on the remaining network and the customer service level. The model is applied to 4 real cases from Maersk Line. Solutions are comparable or superior to those chosen by operations managers. Cost savings of up to 58% may be achieved.......Maritime transportation is the backbone of world trade and is accountable for around 3% of the worlds CO2 emissions. We present the Vessel Schedule Recovery Problem (VSRP) to evaluate a given disruption scenario and to select a recovery action balancing the trade off between increased bunker...

  5. Nuclear power plant pressure vessels. Inservice inspections

    International Nuclear Information System (INIS)

    1995-01-01

    The requirements for the planning and reporting of inservice inspections of nuclear power plant pressure vessels are presented. The guide specifically applies to inservice inspections of Safety class 1 and 2 nuclear power plant pressure vessels, piping, pumps and valves plus their supports and reactor pressure vessel internals by non- destructive examination methods (NDE). Inservice inspections according to the Pressure Vessel Degree (549/73) are discussed separately in the guide YVL 3.0. (4 refs.)

  6. Expanded Fermilab pressure vessel directory program

    Energy Technology Data Exchange (ETDEWEB)

    Tanner, A.

    1983-01-01

    Several procedures have been written to manage the information pertaining to the vacuum tanks and pressure vessels for which the laboratory is responsible. These procedures have been named TANK1 for the vessels belonging to the Accelerator Division, TANK2 and TANK3 for the vessels belonging to the Research Division and to Technical Support respectively, and TANK4 for the vessels belonging to the Business Division. The operating procedures are otherwise identical in every respect.

  7. Expanded Fermilab pressure vessel directory program

    International Nuclear Information System (INIS)

    Tanner, A.

    1983-01-01

    Several procedures have been written to manage the information pertaining to the vacuum tanks and pressure vessels for which the laboratory is responsible. These procedures have been named TANK1 for the vessels belonging to the Accelerator Division, TANK2 and TANK3 for the vessels belonging to the Research Division and to Technical Support respectively, and TANK4 for the vessels belonging to the Business Division. The operating procedures are otherwise identical in every respect

  8. Vacuum vessel for plasma devices

    International Nuclear Information System (INIS)

    Yamada, Masao; Taguchi, Masami.

    1975-01-01

    Object: To permit effective utility of the space in the inner and outer sides of the container wall and also permit repeated assembly for use. Structure: Vacuum vessel wall sections are sealed together by means of welding bellows, and also flange portions formed at the end of the wall sections are coupled together by bolts and are sealed together with a seal ring and a seal cap secured by welding. (Nakamura, S.)

  9. Reactor vessel head permanent shield

    International Nuclear Information System (INIS)

    Hankinson, M.F.; Leduc, R.J.; Richard, J.W.; Malandra, L.J.

    1989-01-01

    A nuclear reactor is described comprising: a nuclear reactor pressure vessel closure head; control rod drive mechanisms (CRDMs) disposed within the closure head so as to project vertically above the closure head; cooling air baffle means surrounding the control rod drive mechanisms for defining cooling air paths relative to the control rod drive mechanisms; means defined within the periphery of the closure head for accommodating fastening means for securing the closure head to its associated pressure vessel; lifting lugs fixedly secured to the closure head for facilitating lifting and lowering movements of the closure head relative to the pressure vessel; lift rods respectively operatively associated with the plurality of lifting lugs for transmitting load forces, developed during the lifting and lowering movements of the closure head, to the lifting lugs; upstanding radiation shield means interposed between the cooling air baffle means and the periphery of the enclosure head of shielding maintenance personnel operatively working upon the closure head fastening means from the effects of radiation which may emanate from the control rod drive mechanisms and the cooling air baffle means; and connecting systems respectively associated with each one of the lifting lugs and each one of the lifting rods for connecting each one of the lifting rods to a respective one of each one of the lifting lugs, and for simultaneously connecting a lower end portion of the upstanding radiation shield means to each one of the respective lifting lugs

  10. Reactor-vessel-sectioning demonstration

    International Nuclear Information System (INIS)

    Lundgren, R.A.

    1981-09-01

    A technical demonstration was successfully completed of simulated reactor vessel sectioning using the combined techniques of air arc gouging and flame cutting. A 4-ft x 3-ft x 9-in. thick sample was fabricated of A36 carbon steel to simulate a reactor vessel wall. A 1/4-in. layer of stainless steel (SS) was tungsten inert gas (TIG)-welded to the carbon steel. Several techniques were considered to section the simulated reactor vessel; air arc gouging was selected to penetrate the stainless steel, and flame cutting was selected to sever the carbon steel. Three sectioning operations were demonstrated. For all three, the operating parameters were the same; but the position of the sample was varied. For the first cut, the sample was placed in a horizontal position, and it was successfully severed from the SS side. For the second cut, the sample was turned over and cut from the carbon steel side. Cutting from the carbon steel side has the advantages of cost reduction

  11. 33 CFR 151.1512 - Vessel safety.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Vessel safety. 151.1512 Section... River § 151.1512 Vessel safety. Nothing in this subpart relieves the master of the responsibility for ensuring the safety and stability of the vessel or the safety of the crew and passengers, or any other...

  12. Reactor vessel supported by flexure member

    International Nuclear Information System (INIS)

    Crawford, J.D.; Pankow, B.

    1975-01-01

    A description is given of a reactor pressure vessel which is provided with vertical support means in the form of circumferentially spaced columns upon which the vessel is mounted. The columns are adapted to undergo flexure in order to accommodate the thermally induced displacements experienced by the vessel during operational transients

  13. 19 CFR 4.97 - Salvage vessels.

    Science.gov (United States)

    2010-04-01

    ... United States and Great Britain ‘concerning reciprocal rights for United States and Canada in the... meaning of this statute. (e) A Mexican vessel may engage in a salvage operation on a Mexican vessel in any territorial waters of the United States in which Mexican vessels are permitted to conduct such operations by...

  14. Model tests for prestressed concrete pressure vessels

    International Nuclear Information System (INIS)

    Stoever, R.

    1975-01-01

    Investigations with models of reactor pressure vessels are used to check results of three dimensional calculation methods and to predict the behaviour of the prototype. Model tests with 1:50 elastic pressure vessel models and with a 1:5 prestressed concrete pressure vessel are described and experimental results are presented. (orig.) [de

  15. 50 CFR 648.4 - Vessel permits.

    Science.gov (United States)

    2010-10-01

    ... carrying passengers for hire. (8) Atlantic bluefish vessels. (i) Commercial. Any vessel of the United... lands Atlantic bluefish in or from the EEZ in excess of the recreational possession limit specified at § 648.164 must have been issued and carry on board a valid commercial bluefish vessel permit. (ii) Party...

  16. Integrating Multiple Autonomous Underwater Vessels, Surface Vessels and Aircraft into Oceanographic Research Vessel Operations

    Science.gov (United States)

    McGillivary, P. A.; Borges de Sousa, J.; Martins, R.; Rajan, K.

    2012-12-01

    Autonomous platforms are increasingly used as components of Integrated Ocean Observing Systems and oceanographic research cruises. Systems deployed can include gliders or propeller-driven autonomous underwater vessels (AUVs), autonomous surface vessels (ASVs), and unmanned aircraft systems (UAS). Prior field campaigns have demonstrated successful communication, sensor data fusion and visualization for studies using gliders and AUVs. However, additional requirements exist for incorporating ASVs and UASs into ship operations. For these systems to be optimally integrated into research vessel data management and operational planning systems involves addressing three key issues: real-time field data availability, platform coordination, and data archiving for later analysis. A fleet of AUVs, ASVs and UAS deployed from a research vessel is best operated as a system integrated with the ship, provided communications among them can be sustained. For this purpose, Disruptive Tolerant Networking (DTN) software protocols for operation in communication-challenged environments help ensure reliable high-bandwidth communications. Additionally, system components need to have considerable onboard autonomy, namely adaptive sampling capabilities using their own onboard sensor data stream analysis. We discuss Oceanographic Decision Support System (ODSS) software currently used for situational awareness and planning onshore, and in the near future event detection and response will be coordinated among multiple vehicles. Results from recent field studies from oceanographic research vessels using AUVs, ASVs and UAS, including the Rapid Environmental Picture (REP-12) cruise, are presented describing methods and results for use of multi-vehicle communication and deliberative control networks, adaptive sampling with single and multiple platforms, issues relating to data management and archiving, and finally challenges that remain in addressing these technological issues. Significantly, the

  17. A Comparative Assessment of Spalart-Shur Rotation/Curvature Correction in RANS Simulations in a Centrifugal Pump Impeller

    Directory of Open Access Journals (Sweden)

    Ran Tao

    2014-01-01

    Full Text Available RANS simulation is widely used in the flow prediction of centrifugal pumps. Influenced by impeller rotation and streamline curvature, the eddy viscosity models with turbulence isotropy assumption are not accurate enough. In this study, Spalart-Shur rotation/curvature correction was applied on the SST k-ω turbulence model. The comparative assessment of the correction was proceeded in the simulations of a centrifugal pump impeller. CFD results were compared with existing PIV and LDV data under the design and low flow rate off-design conditions. Results show the improvements of the simulation especially in the situation that turbulence strongly produced due to undesirable flow structures. Under the design condition, more reasonable turbulence kinetic energy contour was captured after correction. Under the low flow rate off-design condition, the prediction of turbulence kinetic energy and velocity distributions became much more accurate when using the corrected model. So, the rotation/curvature correction was proved effective in this study. And, it is also proved acceptable and recommended to use in the engineering simulations of centrifugal pump impellers.

  18. Zonal RANS/LES coupling simulation of a transitional and separated flow around an airfoil near stall

    Energy Technology Data Exchange (ETDEWEB)

    Richez, F.; Mary, I.; Gleize, V. [ONERA, Department of Computational Fluid Dynamics and Aeroacoustics, 29 Avenue de la Division Leclerc, BP 72, Chatillon (France); Basdevant, C. [Universite Paris-Nord, Laboratoire d' Analyse, Geometrie et Applications, CNRS, Villetaneuse (France)

    2008-05-15

    The objective of the current study is to examine the course of events leading to stall just before its occurrence. The stall mechanisms are very sensitive to the transition that the boundary layer undergoes near the leading edge of the profile by a so-called laminar separation bubble (LSB). In order to provide helpful insights into this complex flow, a zonal Reynolds-averaged Navier-Stokes (RANS)/large-eddy simulation (LES) simulation of the flow around an airfoil near stall has been achieved and its results are presented and analyzed in this paper. LSB has already been numerically studied by direct numerical simulation (DNS) or LES, but for a flat plate with an adverse pressure gradient only. We intend, in this paper, to achieve a detailed analysis of the transition process by a LSB in more realistic conditions. The comparison with a linear instability analysis has shown that the numerical instability mechanism in the LSB provides the expected frequency of the perturbations. Furthermore, the right order of magnitude for the turbulence intensities at the reattachment point is found. (orig.)

  19. Flaw distribution development from vessel ISI data

    International Nuclear Information System (INIS)

    Foulds, J.R.; Kennedy, E.L.; Basin, S.L.; Rosinski, S.T.

    1991-01-01

    Previous attempts to develop flaw distributions for use in the structural integrity evaluation of pressurized water reactor (PWR) vessels have aimed at the estimation of a ''generic'' distribution applicable to all vessels. In contrast, this paper describes the analysis of vessel-specific in-service inspection (ISI) data for the development of a flaw distribution reliably representative of the condition of the particular vessel inspected. The application of the methodology may be extended to other vessels, but has been primarily developed for PWR reactor vessels. For this study, the flaw data analyzed included data obtained from three recently performed PWR vessel ISIs and from laboratory inspection of selected weldment sections of the Midland reactor vessel. The variability in both the character of the reviewed data (size range of flaws, number of flaws) and the UT (ultrasonic test) inspection system performance identified a need for analyzing the inspection results on a vessel-, or data set-specific basis. For this purpose, traditional histogram-based methods were inadequate, and a new methodology that can accept a very small number of flaws (typical of vessel-specific ISI results) and that includes consideration of inspection system flaw detection reliability, flaw sizing accuracy and flaw detection threshold, was developed. Results of the application of the methodology to each of the four PWR reactor vessel cases studied are presented and discussed

  20. Primo vessel inside a lymph vessel emerging from a cancer tissue.

    Science.gov (United States)

    Lee, Sungwoo; Ryu, Yeonhee; Cha, Jinmyung; Lee, Jin-Kyu; Soh, Kwang-Sup; Kim, Sungchul; Lim, Jaekwan

    2012-10-01

    Primo vessels were observed inside the lymph vessels near the caudal vena cava of a rabbit and a rat and in the thoracic lymph duct of a mouse. In the current work we found a primo vessel inside the lymph vessel that came out from the tumor tissue of a mouse. A cancer model of a nude mouse was made with human lung cancer cell line NCI-H460. We injected fluorescent nanoparticles into the xenografted tumor tissue and studied their flow in blood, lymph, and primo vessels. Fluorescent nanoparticles flowed through the blood vessels quickly in few minutes, and but slowly in the lymph vessels. The bright fluorescent signals of nanoparticles disappeared within one hour in the blood vessels but remained much longer up to several hours in the case of lymph vessels. We found an exceptional case of lymph vessels that remained bright with fluorescence up to 24 hours. After detailed examination we found that the bright fluorescence was due to a putative primo vessel inside the lymph vessel. This rare observation is consistent with Bong-Han Kim's claim on the presence of a primo vascular system in lymph vessels. It provides a significant suggestion on the cancer metastasis through primo vessels and lymph vessels. Copyright © 2012. Published by Elsevier B.V.

  1. What is cerebral small vessel disease?

    International Nuclear Information System (INIS)

    Onodera, Osamu

    2011-01-01

    An accumulating amount of evidence suggests that the white matter hyperintensities on T 2 weighted brain magnetic resonance imaging predict an increased risk of dementia and gait disturbance. This state has been proposed as cerebral small vessel disease, including leukoaraiosis, Binswanger's disease, lacunar stroke and cerebral microbleeds. However, the concept of cerebral small vessel disease is still obscure. To understand the cerebral small vessel disease, the precise structure and function of cerebral small vessels must be clarified. Cerebral small vessels include several different arteries which have different anatomical structures and functions. Important functions of the cerebral small vessels are blood-brain barrier and perivasucular drainage of interstitial fluid from the brain parenchyma. Cerebral capillaries and glial endfeet, take an important role for these functions. However, the previous pathological investigations on cerebral small vessels have focused on larger arteries than capillaries. Therefore little is known about the pathology of capillaries in small vessel disease. The recent discoveries of genes which cause the cerebral small vessel disease indicate that the cerebral small vessel diseases are caused by a distinct molecular mechanism. One of the pathological findings in hereditary cerebral small vessel disease is the loss of smooth muscle cells, which is an also well-recognized finding in sporadic cerebral small vessel disease. Since pericytes have similar character with the smooth muscle cells, the pericytes should be investigated in these disorders. In addition, the loss of smooth muscle cells may result in dysfunction of drainage of interstitial fluid from capillaries. The precise correlation between the loss of smooth muscle cells and white matter disease is still unknown. However, the function that is specific to cerebral small vessel may be associated with the pathogenesis of cerebral small vessel disease. (author)

  2. 46 CFR 4.03-40 - Public vessels.

    Science.gov (United States)

    2010-10-01

    ... INVESTIGATIONS Definitions § 4.03-40 Public vessels. Public vessel means a vessel that— (a) Is owned, or demise... Department (except a vessel operated by the Coast Guard or Saint Lawrence Seaway Development Corporation...

  3. Progress of ITER vacuum vessel

    Energy Technology Data Exchange (ETDEWEB)

    Ioki, K., E-mail: Kimihiro.Ioki@iter.org [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Bayon, A. [F4E, c/ Josep Pla, No. 2, Torres Diagonal Litoral, Edificio B3, E-08019 Barcelona (Spain); Choi, C.H.; Daly, E.; Dani, S.; Davis, J.; Giraud, B.; Gribov, Y.; Hamlyn-Harris, C.; Jun, C.; Levesy, B. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Kim, B.C. [NFRI, 52 Yeoeundong Yuseonggu, Daejeon 305-333 (Korea, Republic of); Kuzmin, E. [NTC “Sintez”, Efremov Inst., 189631 Metallostroy, St. Petersburg (Russian Federation); Le Barbier, R.; Martinez, J.-M. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Pathak, H. [ITER-India, A-29, GIDC Electronic Estate, Sector 25, Gandhinagar 382025 (India); Preble, J. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Sa, J.W. [NFRI, 52 Yeoeundong Yuseonggu, Daejeon 305-333 (Korea, Republic of); Terasawa, A.; Utin, Yu. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); and others

    2013-10-15

    Highlights: ► This covers the overall status and progress of the ITER vacuum vessel activities. ► It includes design, R and D, manufacturing and approval process of the regulators. ► The baseline design was completed and now manufacturing designs are on-going. ► R and D includes ISI, dynamic test of keys and lip-seal welding/cutting technology. ► The VV suppliers produced full-scale mock-ups and started VV manufacturing. -- Abstract: Design modifications were implemented in the vacuum vessel (VV) baseline design in 2011–2012 for finalization. The modifications are mostly due to interface components, such as support rails and feedthroughs for the in-vessel coils (IVC). Manufacturing designs are being developed at the domestic agencies (DAs) based on the baseline design. The VV support design was also finalized and tests on scale mock-ups are under preparation. Design of the in-wall shielding (IWS) has progressed, considering the assembly methods and the required tolerances. Further modifications are required to be consistent with the DAs’ manufacturing designs. Dynamic tests on the inter-modular and stub keys to support the blanket modules are being performed to measure the dynamic amplification factor (DAF). An in-service inspection (ISI) plan has been developed and R and D was launched for ISI. Conceptual design of the VV instrumentation has been developed. The VV baseline design was approved by the agreed notified body (ANB) in accordance with the French Nuclear Pressure Equipment Order procedure.

  4. Progress of ITER vacuum vessel

    International Nuclear Information System (INIS)

    Ioki, K.; Bayon, A.; Choi, C.H.; Daly, E.; Dani, S.; Davis, J.; Giraud, B.; Gribov, Y.; Hamlyn-Harris, C.; Jun, C.; Levesy, B.; Kim, B.C.; Kuzmin, E.; Le Barbier, R.; Martinez, J.-M.; Pathak, H.; Preble, J.; Sa, J.W.; Terasawa, A.; Utin, Yu.

    2013-01-01

    Highlights: ► This covers the overall status and progress of the ITER vacuum vessel activities. ► It includes design, R and D, manufacturing and approval process of the regulators. ► The baseline design was completed and now manufacturing designs are on-going. ► R and D includes ISI, dynamic test of keys and lip-seal welding/cutting technology. ► The VV suppliers produced full-scale mock-ups and started VV manufacturing. -- Abstract: Design modifications were implemented in the vacuum vessel (VV) baseline design in 2011–2012 for finalization. The modifications are mostly due to interface components, such as support rails and feedthroughs for the in-vessel coils (IVC). Manufacturing designs are being developed at the domestic agencies (DAs) based on the baseline design. The VV support design was also finalized and tests on scale mock-ups are under preparation. Design of the in-wall shielding (IWS) has progressed, considering the assembly methods and the required tolerances. Further modifications are required to be consistent with the DAs’ manufacturing designs. Dynamic tests on the inter-modular and stub keys to support the blanket modules are being performed to measure the dynamic amplification factor (DAF). An in-service inspection (ISI) plan has been developed and R and D was launched for ISI. Conceptual design of the VV instrumentation has been developed. The VV baseline design was approved by the agreed notified body (ANB) in accordance with the French Nuclear Pressure Equipment Order procedure

  5. Nuclear reactor pressure vessel flaw distribution development

    International Nuclear Information System (INIS)

    Kennedy, E.L.; Foulds, J.R.; Basin, S.L.

    1991-12-01

    Previous attempts to develop flaw distributions for probabilistic fracture mechanics analyses of pressurized water reactor (PWR) vessels have aimed at the estimation of a ''generic'' distribution applicable to all PWR vessels. In contrast, this report describes (1) a new flaw distribution development analytic methodology that can be applied to the analysis of vessel-specific inservice inspection (ISI) data, and (2) results of the application of the methodology to the analysis of flaw data for each vessel case (ISI data on three PWR vessels and laboratory inspection data on sections of the Midland reactor vessel). Results of this study show significant variation among the flaw distributions derived from the various data sets analyzed, strongly suggesting than a vessel-specific flaw distribution (for vessel integrity prediction under pressurized thermal shock) is preferred over a ''generic'' distribution. In addition, quantitative inspection system flaw sizing accuracy requirements have been identified for developing a flaw distribution from vessel ISI data. The new flaw data analysis methodology also permits quantifying the reliability of the flaw distribution estimate. Included in the report are identified needs for further development of several aspects of ISI data acquisition and vessel integrity prediction practice

  6. Proactive monitoring of a wind turbine array with lidar measurements, SCADA data and a data-driven RANS solver

    Science.gov (United States)

    Iungo, G.; Said, E. A.; Santhanagopalan, V.; Zhan, L.

    2016-12-01

    Power production of a wind farm and durability of wind turbines are strongly dependent on non-linear wake interactions occurring within a turbine array. Wake dynamics are highly affected by the specific site conditions, such as topography and local atmospheric conditions. Furthermore, contingencies through the life of a wind farm, such as turbine ageing and off-design operations, make prediction of wake interactions and power performance a great challenge in wind energy. In this work, operations of an onshore wind turbine array were monitored through lidar measurements, SCADA and met-tower data. The atmospheric wind field investing the wind farm was estimated by using synergistically the available data through five different methods, which are characterized by different confidence levels. By combining SCADA data and the lidar measurements, it was possible to estimate power losses connected with wake interactions. For this specific array, power losses were estimated to be 4% and 2% of the total power production for stable and convective atmospheric regimes, respectively. The entire dataset was then leveraged for the calibration of a data-driven RANS (DDRANS) solver for prediction of wind turbine wakes and power production. The DDRANS is based on a parabolic formulation of the Navier-Stokes equations with axisymmetry and boundary layer approximations, which allow achieving very low computational costs. Accuracy in prediction of wind turbine wakes and power production is achieved through an optimal tuning of the turbulence closure model. The latter is based on a mixing length model, which was developed based on previous wind turbine wake studies carried out through large eddy simulations and wind tunnel experiments. Several operative conditions of the wind farm under examination were reproduced through DDRANS for different stability regimes, wind directions and wind velocity. The results show that DDRANS is capable of achieving a good level of accuracy in prediction

  7. Toward the Validation of Depth-Averaged Three Dimensional, Rans Steady-State Simulations of Fluvial Flows at Natural Scale

    Science.gov (United States)

    Mateo Villanueva, P. A.; Hradisky, M.

    2010-12-01

    Simulations of fluvial flows are strongly influenced by geometric complexity and overall uncertainty on measured flow variables, including those assumed to be well known boundary conditions. Often, 2D steady-state models are used for computational simulations of flows at the scale of natural rivers. Such models have been successfully incorporated in iRIC (formerly MD_SWMS), one of the widely used quasi-3D CFD solvers to perform studies of environmental flows. iRIC aids in estimating such quantities as surface roughness and shear stress, which, in turn, can be used to estimate sediment transport. However, the computational results are inherently limited in accuracy because of restricting the computations to 2D, or quasi-3D, space, which can affect the values of these predictions. In the present work we perform computer-based simulations of fluvial flows using OpenFOAM, a free, open source fully 3D CFD software package, and compare our results to predictions obtained from iRIC. First, we study the suitability of OpenFOAM as the main CFD solver to analyze fluvial flows and validate our results for two well documented rectangular channel configurations: the first case consists of a large aspect-ratio channel (ratio of depth over width 0.017, ratio of depth over length 0.0019) with a rectangular obstacle mounted at the bottom wall; the second case involves a large aspect-ratio channel (ratio of depth over width 0.1, ratio of depth over length 0.0025) with cubic obstacles mounted at the lower wall (one obstacle) and upper wall (two obstacles). Secondly, we apply our model to simulation or river at natural scale and compare our results to the output obtained from iRIC to quantify the differences in velocity profiles and other flow parameters when comparable solution techniques are used. Steady-state, RANS k-epsilon models are employed for all simulations.

  8. Hydrogen storage in insulated pressure vessels

    Energy Technology Data Exchange (ETDEWEB)

    Aceves, S.M.; Garcia-Villazana, O. [Lawrence Livermore National Lab., CA (United States)

    1998-08-01

    Insulated pressure vessels are cryogenic-capable pressure vessels that can be fueled with liquid hydrogen (LH{sub 2}) or ambient-temperature compressed hydrogen (CH{sub 2}). Insulated pressure vessels offer the advantages of liquid hydrogen tanks (low weight and volume), with reduced disadvantages (lower energy requirement for hydrogen liquefaction and reduced evaporative losses). This paper shows an evaluation of the applicability of the insulated pressure vessels for light-duty vehicles. The paper shows an evaluation of evaporative losses and insulation requirements and a description of the current analysis and experimental plans for testing insulated pressure vessels. The results show significant advantages to the use of insulated pressure vessels for light-duty vehicles.

  9. Neutron Assay System for Confinement Vessel Disposition

    International Nuclear Information System (INIS)

    Frame, Katherine C.; Bourne, Mark M.; Crooks, William J.; Evans, Louise; Mayo, Douglas R.; Miko, David K.; Salazar, William R.; Stange, Sy; Valdez, Jose I.; Vigil, Georgiana M.

    2012-01-01

    Los Alamos National Laboratory has a number of spherical confinement vessels (CVs) remaining from tests involving nuclear materials. These vessels have an inner diameter of 6 feet with 1-inch thick steel walls. The goal of the Confinement Vessel Disposition (CVD) project is to remove debris and reduce contamination inside the CVs. The Confinement Vessel Assay System (CVAS) was developed to measure the amount of special nuclear material (SNM) in CVs before and after cleanout. Prior to cleanout, the system will be used to perform a verification measurement of each vessel. After cleanout, the system will be used to perform safeguards-quality assays of (le)100-g 239 Pu equivalent in a vessel for safeguards termination. The CVAS has been tested and calibrated in preparation for verification and safeguards measurements.

  10. Automatic Vessel Segmentation on Retinal Images

    Institute of Scientific and Technical Information of China (English)

    Chun-Yuan Yu; Chia-Jen Chang; Yen-Ju Yao; Shyr-Shen Yu

    2014-01-01

    Several features of retinal vessels can be used to monitor the progression of diseases. Changes in vascular structures, for example, vessel caliber, branching angle, and tortuosity, are portents of many diseases such as diabetic retinopathy and arterial hyper-tension. This paper proposes an automatic retinal vessel segmentation method based on morphological closing and multi-scale line detection. First, an illumination correction is performed on the green band retinal image. Next, the morphological closing and subtraction processing are applied to obtain the crude retinal vessel image. Then, the multi-scale line detection is used to fine the vessel image. Finally, the binary vasculature is extracted by the Otsu algorithm. In this paper, for improving the drawbacks of multi-scale line detection, only the line detectors at 4 scales are used. The experimental results show that the accuracy is 0.939 for DRIVE (digital retinal images for vessel extraction) retinal database, which is much better than other methods.

  11. Electrical discharge machining for vessel sample removal

    International Nuclear Information System (INIS)

    Litka, T.J.

    1993-01-01

    Due to aging-related problems or essential metallurgy information (plant-life extension or decommissioning) of nuclear plants, sample removal from vessels may be required as part of an examination. Vessel or cladding samples with cracks may be removed to determine the cause of cracking. Vessel weld samples may be removed to determine the weld metallurgy. In all cases, an engineering analysis must be done prior to sample removal to determine the vessel's integrity upon sample removal. Electrical discharge machining (EDM) is being used for in-vessel nuclear power plant vessel sampling. Machining operations in reactor coolant system (RCS) components must be accomplished while collecting machining chips that could cause damage if they become part of the flow stream. The debris from EDM is a fine talclike particulate (no chips), which can be collected by flushing and filtration

  12. Ran is a potential therapeutic target for cancer cells with molecular changes associated with activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways

    Science.gov (United States)

    Yuen, Hiu-Fung; Chan, Ka-Kui; Grills, Claire; Murray, James T.; Platt-Higgins, Angela; Eldin, Osama Sharaf; O’Byrne, Ken; Janne, Pasi; Fennell, Dean A.; Johnston, Patrick G.; Rudland, Philip S.; El-Tanani, Mohamed

    2011-01-01

    Purpose Cancer cells have been shown to be more susceptible to Ran knockdown compared to normal cells. We now investigate whether Ran is a potential therapeutic target of cancers with frequently found mutations that lead to higher Ras/MEK/ERK and PI3K/Akt/mTORC1 activities. Experimental Design Apoptosis was measured by flow cytometry (PI and Annexin V staining) and MTT assay in cancer cells grown under different conditions after knockdown of Ran.. The correlations between Ran expression and patient survival were examined in breast and lung cancers. Results Cancer cells with their PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways inhibited are less susceptible to Ran silencing-induced apoptosis. KRas mutated, c-Met amplified and Pten-deleted cancer cells are also more susceptible to Ran silencing-induced apoptosis than their wild-type counterparts and this effect is reduced by inhibitors of the PI3K/Akt/mTORC1 and MEK/ERK pathways. Overexpression of Ran in clinical specimens is significantly associated with poor patient outcome in both breast and lung cancers. This association is dramatically enhanced in cancers with increased c-Met or osteopontin expression, or with oncogenic mutations of KRas or PIK3CA, all of which are mutations that potentially correlate with activation of the PI3K/Akt/mTORC1 and/or Ras/MEK/ERK pathways. Silencing Ran also results in dysregulation of nucleocytoplasmic transport of transcription factors and downregulation of Mcl-1 expression, at the transcriptional level, which are reversed by inhibitors of the PI3K/Akt/mTORC1 and MEK/ERK pathways. Conclusion Ran is a potential therapeutic target for treatment of cancers with mutations/changes of expression in protooncogenes that lead to activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways. PMID:22090358

  13. Exponential Stabilization of an Underactuated Surface Vessel

    Directory of Open Access Journals (Sweden)

    Kristin Y. Pettersen

    1997-07-01

    Full Text Available The paper shows that a large class of underactuated vehicles cannot be asymptotically stabilized by either continuous or discontinuous state feedback. Furthermore, stabilization of an underactuated surface vessel is considered. Controllability properties of the surface vessels is presented, and a continuous periodic time-varying feedback law is proposed. It is shown that this feedback law exponentially stabilizes the surface vessel to the origin, and this is illustrated by simulations.

  14. Computerized reactor pressure vessel materials information system

    International Nuclear Information System (INIS)

    Strosnider, J.; Monserrate, C.; Kenworthy, L.D.; Tether, C.D.

    1980-10-01

    A computerized information system for storage and retrieval of reactor pressure vessel materials data was established, as part of Task Action Plan A-11, Reactor Vessel Materials Toughness. Data stored in the system are necessary for evaluating the resistance of reactor pressure vessels to flaw-induced fracture. This report includes (1) a description of the information system; (2) guidance on accessing the system; and (3) a user's manual for the system

  15. Application of the order-of-magnitude analysis to a fourth-order RANS closure for simulating a 2D boundary layer

    Science.gov (United States)

    Poroseva, Svetlana V.

    2013-11-01

    Simulations of turbulent boundary-layer flows are usually conducted using a set of the simplified Reynolds-Averaged Navier-Stokes (RANS) equations obtained by order-of-magnitude analysis (OMA) of the original RANS equations. The resultant equations for the mean-velocity components are closed using the Boussinesq approximation for the Reynolds stresses. In this study OMA is applied to the fourth-order RANS (FORANS) set of equations. The FORANS equations are chosen as they can be closed on the level of the 5th-order correlations without using unknown model coefficients, i.e. no turbulent diffusion modeling is required. New models for the 2nd-, 3rd- and 4th-order velocity-pressure gradient correlations are derived for the current FORANS equations. This set of FORANS equations and models are analyzed for the case of two-dimensional mean flow. The equations include familiar transport terms for the mean-velocity components along with algebraic expressions for velocity correlations of different orders specific to the FORANS approach. Flat plate DNS data (Spalart, 1988) are used to verify these expressions and the areas of the OMA applicability within the boundary layer. The material is based upon work supported by NASA under award NNX12AJ61A.

  16. Analysis of multiuser mixed RF/FSO relay networks for performance improvements in Cloud Computing-Based Radio Access Networks (CC-RANs)

    Science.gov (United States)

    Alimi, Isiaka A.; Monteiro, Paulo P.; Teixeira, António L.

    2017-11-01

    The key paths toward the fifth generation (5G) network requirements are towards centralized processing and small-cell densification systems that are implemented on the cloud computing-based radio access networks (CC-RANs). The increasing recognitions of the CC-RANs can be attributed to their valuable features regarding system performance optimization and cost-effectiveness. Nevertheless, realization of the stringent requirements of the fronthaul that connects the network elements is highly demanding. In this paper, considering the small-cell network architectures, we present multiuser mixed radio-frequency/free-space optical (RF/FSO) relay networks as feasible technologies for the alleviation of the stringent requirements in the CC-RANs. In this study, we use the end-to-end (e2e) outage probability, average symbol error probability (ASEP), and ergodic channel capacity as the performance metrics in our analysis. Simulation results show the suitability of deployment of mixed RF/FSO schemes in the real-life scenarios.

  17. Numerical investigation of the vortex-induced vibration of an elastically mounted circular cylinder at high Reynolds number (Re = 104 and low mass ratio using the RANS code.

    Directory of Open Access Journals (Sweden)

    Niaz Bahadur Khan

    Full Text Available This study numerically investigates the vortex-induced vibration (VIV of an elastically mounted rigid cylinder by using Reynolds-averaged Navier-Stokes (RANS equations with computational fluid dynamic (CFD tools. CFD analysis is performed for a fixed-cylinder case with Reynolds number (Re = 104 and for a cylinder that is free to oscillate in the transverse direction and possesses a low mass-damping ratio and Re = 104. Previously, similar studies have been performed with 3-dimensional and comparatively expensive turbulent models. In the current study, the capability and accuracy of the RANS model are validated, and the results of this model are compared with those of detached eddy simulation, direct numerical simulation, and large eddy simulation models. All three response branches and the maximum amplitude are well captured. The 2-dimensional case with the RANS shear-stress transport k-w model, which involves minimal computational cost, is reliable and appropriate for analyzing the characteristics of VIV.

  18. The E7 oncoprotein of high-risk human papillomavirus type 16 enters the nucleus via a nonclassical Ran-dependent pathway

    International Nuclear Information System (INIS)

    Angeline, Michael; Merle, Eric; Moroianu, Junona

    2003-01-01

    E7, the major transforming protein of high-risk human papillomavirus (HPV), type 16, binds and inactivates the retinoblastoma protein (pRb), and the Rb-related proteins p107 and p130. HPV16 E7 is a nuclear protein lacking a classical basic nuclear localization signal. In this study we investigated the nuclear import of HPV16 E7 oncoprotein in digitonin-permeabilized HeLa cells. HPV16 E7 nuclear import was independent of pRb, as an E7 ΔDLYC variant defective in pRb binding was imported into the nuclei of digitonin-permeabilized cells as efficiently as wild-type E7 in the presence of exogenous cytosol. Interestingly, we discovered that HPV16 E7 is imported into the nuclei via a novel pathway different from those mediated by Kap α2β1 heterodimers, Kap β1, or Kap β2. Nuclear accumulation of E7 required Ran and was not inhibited by the RanG19V-GTP variant, an inhibitor of Kap β mediated import pathways. Together the data suggest that HPV16 E7 translocates through the nuclear pores via a nonclassical Ran-dependent pathway, independent of the main cytosolic Kap β import receptors

  19. How to replace a reactor pressure vessel

    International Nuclear Information System (INIS)

    Huber, R.

    1996-01-01

    A potential life extending procedure for a nuclear reactor after, say, 40 years of service life, might in some circumstances be the replacement of the reactor pressure vessel. Neutron induced degradation of the vessel might make replacement by one of a different material composition desirable, for example. Although the replacement of heavy components, such as steam generators, has been possible for many years, the pressure vessel presents a much more demanding task if only because it is highly irradiated. Some preliminary feasibility studies by Siemens are reported for the two removal strategies that might be considered. These are removal of the entire pressure vessel in one piece and dismantling it into sections. (UK)

  20. Prestressed reactor vessel for nuclear power plants

    International Nuclear Information System (INIS)

    Schoening, J.; Schwiers, H.G.

    1982-01-01

    With usual pressure vessels for nuclear reactor plants, especially for gas-cooled nuclear reactors, the load occurring due to the inner overpressure, especially the tensile load affecting the vessel top and/or bottom, their axis of inertia being horizontal, shall be compensated without a supplementary modification in design of the top and/or the bottom. This is attained by choosing an appropriate prestressing system of the vessel wall in the field the top and/or the bottom, so that the top and/or the bottom form a tension vault directed towards the interior of the vessel. (orig.) [de

  1. Reactor vessel decommissioning project. Final report

    International Nuclear Information System (INIS)

    Schoonen, D.H.

    1984-09-01

    This report describes a reactor vessel decommissioning project; it documents and explains the project objectives, scope, performance results, and sodium removal process. The project was successfully completed in FY-1983, within budget and without significant problems or adverse impact on the environment. Waste generated by the operation included the reactor vessel, drained sodium, and liquid, solid, and gaseous wastes which were significantly less than project estimates. Personnel radiation exposures were minimized, such that the project total was one-half the predicted exposure level. Except for the sodium removed, the material remaining in the reactor vessel is essentially the same as when the vessel arrived for processing

  2. Safety vessels for explosive fusion reactor

    International Nuclear Information System (INIS)

    Mineev, V.

    1994-01-01

    The failure of several types of geometrically similar cylindrical and spherical steel and glass fibers vessels filled with water or air was investigated when an explosive charge of TNT was detonated in the center. Vessels had radius 50-1000 mm, thickness of walls 2-20%. The detonation on TNT imitated energy release. The parameter: K = M/mf is a measure of the strength of the vessel where M is the mass of the vessel, and mf is the mass of TNT for which the vessel fails. This demanded 2-4 destroyed and nondestroyed shots. It may be showed that: K=A/σ f where σ f is the fracture stress of the material vessel, and A = const = F(energy TNT, characteristic of elasticity of vessel material). The chief results are the following: (1) A similar increase in the geometrical dimensions of steel vessels by a factor of 10 leads to the increase of parameter K in about 5 times and to decrease of failure deformation in 7 times (scale effect). (2) For glass fibers, scale effect is absent. (3) This problem is solved in terms of theory energetic scale effect. (4) The concept of TNT equivalent explosive makes it possible to use these investigations to evaluate the response of safety vessels for explosive fusion reactor

  3. Determinants of injuries in passenger vessel accidents.

    Science.gov (United States)

    Yip, Tsz Leung; Jin, Di; Talley, Wayne K

    2015-09-01

    This paper investigates determinants of crew and passenger injuries in passenger vessel accidents. Crew and passenger injury equations are estimated for ferry, ocean cruise, and river cruise vessel accidents, utilizing detailed data of individual vessel accidents that were investigated by the U.S. Coast Guard during the time period 2001-2008. The estimation results provide empirical evidence (for the first time in the literature) that crew injuries are determinants of passenger injuries in passenger vessel accidents. Copyright © 2015 Elsevier Ltd. All rights reserved.

  4. Increase of cyclic durability of pressure vessels

    International Nuclear Information System (INIS)

    Vorona, V.A.; Zvezdin, Yu.I.

    1980-01-01

    The durability of multilayer pressure vessels under cyclic loading is compared with single-layer vessels. The relative conditional durability is calculated taking into account the assumption on the consequent destruction of layers and viewing a vessel wall as an indefinite plate. It is established that the durability is mainly determined by the number of layers and to a lesser degree depends on the relative size of the defect for the given layer thickness. The advantage of the multilayer vessels is the possibility of selecting layer materials so that to exclude the effect of agressive corrosion media on the strength [ru

  5. Vessel size measurements in angiograms: Manual measurements

    International Nuclear Information System (INIS)

    Hoffmann, Kenneth R.; Dmochowski, Jacek; Nazareth, Daryl P.; Miskolczi, Laszlo; Nemes, Balazs; Gopal, Anant; Wang Zhou; Rudin, Stephen; Bednarek, Daniel R.

    2003-01-01

    Vessel size measurement is perhaps the most often performed quantitative analysis in diagnostic and interventional angiography. Although automated vessel sizing techniques are generally considered to have good accuracy and precision, we have observed that clinicians rarely use these techniques in standard clinical practice, choosing to indicate the edges of vessels and catheters to determine sizes and calibrate magnifications, i.e., manual measurements. Thus, we undertook an investigation of the accuracy and precision of vessel sizes calculated from manually indicated edges of vessels. Manual measurements were performed by three neuroradiologists and three physicists. Vessel sizes ranged from 0.1-3.0 mm in simulation studies and 0.3-6.4 mm in phantom studies. Simulation resolution functions had full-widths-at-half-maximum (FWHM) ranging from 0.0 to 0.5 mm. Phantom studies were performed with 4.5 in., 6 in., 9 in., and 12 in. image intensifier modes, magnification factor = 1, with and without zooming. The accuracy and reproducibility of the measurements ranged from 0.1 to 0.2 mm, depending on vessel size, resolution, and pixel size, and zoom. These results indicate that manual measurements may have accuracies comparable to automated techniques for vessels with sizes greater than 1 mm, but that automated techniques which take into account the resolution function should be used for vessels with sizes smaller than 1 mm

  6. Vessels for elevated temperature service

    International Nuclear Information System (INIS)

    O'Donnell, W.J.; Porowski, J.S.

    1983-01-01

    The subject is covered in chapters, entitled: introduction (background; elevated temperature concerns; design tools); design of pressure vessels for elevated temperature per ASME code; basic elevated temperature failure modes; allowable stresses and strains per ASME code (basic allowable stress limits; ASME code limits for bending; time-fraction summations; strain limits; buckling and instability; negligible creep and stress-rupture effects); combined membrane and bending stresses in creep regime; thermal stress cycles; bounding methods based on elastic core concept (bounds on accumulated strains; more accurate bounds; strain ranges; maximum stresses; strains at discontinuities); elastic follow-up; creep strain concentrations; time-dependent fatigue (combined creep rupture and fatigue damage; limits for inelastic design analyses; limits for elastic design analyses); flaw evaluation techniques; type 316 stainless steel; type 304 stainless steel; steel 2 1/4Cr1Mo; Inconel 718; Incolloy 800; Hastelloy X; detailed inelastic design analyses. (U.K.)

  7. Milestones in pressure vessel technology

    International Nuclear Information System (INIS)

    Spence, J.; Nash, D.H.

    2004-01-01

    The progress of pressure vessel technology over the years has been influenced by many important events. This paper identifies a number of 'milestones' which have provided a stimulus to analysis methods, manufacturing, operational processes and new pressure equipment. The formation of a milestone itself along with its subsequent development is often critically dependent on the work of many individuals. It is postulated that such developments takes place in cycles, namely, an initial idea, followed sometimes by unexpected failures, which in turn stimulate analysis or investigation, and when confidence is established, followed finally by the emergence of codes ad standards. Starting from the industrial revolution, key milestones are traced through to the present day and beyond

  8. Reactor pressure vessel thermal annealing

    International Nuclear Information System (INIS)

    Lee, A.D.

    1997-01-01

    The steel plates and/or forgings and welds in the beltline region of a reactor pressure vessel (RPV) are subject to embrittlement from neutron irradiation. This embrittlement causes the fracture toughness of the beltline materials to be less than the fracture toughness of the unirradiated material. Material properties of RPVs that have been irradiated and embrittled are recoverable through thermal annealing of the vessel. The amount of recovery primarily depends on the level of the irradiation embrittlement, the chemical composition of the steel, and the annealing temperature and time. Since annealing is an option for extending the service lives of RPVs or establishing less restrictive pressure-temperature (P-T) limits; the industry, the Department of Energy (DOE) and the Nuclear Regulatory Commission (NRC) have assisted in efforts to determine the viability of thermal annealing for embrittlement recovery. General guidance for in-service annealing is provided in American Society for Testing and Materials (ASTM) Standard E 509-86. In addition, the American Society of Mechanical Engineers (ASME) Code Case N-557 addresses annealing conditions (temperature and duration), temperature monitoring, evaluation of loadings, and non-destructive examination techniques. The NRC thermal annealing rule (10 CFR 50.66) was approved by the Commission and published in the Federal Register on December 19, 1995. The Regulatory Guide on thermal annealing (RG 1.162) was processed in parallel with the rule package and was published on February 15, 1996. RG 1.162 contains a listing of issues that need to be addressed for thermal annealing of an RPV. The RG also provides alternatives for predicting re-embrittlement trends after the thermal anneal has been completed. This paper gives an overview of methodology and recent technical references that are associated with thermal annealing. Results from the DOE annealing prototype demonstration project, as well as NRC activities related to the

  9. Structural analysis of the KSTAR vacuum vessel

    Energy Technology Data Exchange (ETDEWEB)

    In, Sang Ryul; Yoon, Byeong Joo [Korea Atomic Energy Research Institute, Taejon (Korea)

    1998-10-01

    Structure analysis of the vacuum vessel for the KSTAR tokamak which, is in the end phase of the conceptual design have been performed. Mechanical stresses and deformations of the vessel produced by constant forces due to atmospheric pressure, dead weight, fluid pressure, etc and various transient electromagnetic forces induced during tokamak operations were calculated as well as modal characteristics and buckling properties were investigated. Influences of the temperature gradient and the constraint condition of the support on the thermal stress and deformation of the vessel were analyzed. The thermal stress due to the temperature distribution on the vessel as supplying the N{sub 2} gas of 400 deg C through poloidal channels according to the recent baking concept were calculated. No severe problem in the robustness of the vessel was found when applying the constant pressures on the vessel. However the mechanical stress due to the EM force induced by halo currents flowing on the vessel and the plasma facing components (PFCs) far exceeded the allowable limit. Some reinforcing components should be added on the boundary of the PFC support and the vessel, and that of the vessel support and the vessel. A steep temperature gradient in the vicinity of the inlet and oulet of the heating gas produced a thermal stress much higher than allowable. It is necessary to make the temperature of the vessel as uniform as possible and to develop a new support concept which is flexible enough to accommodate a thermal expansion of a few cm while sufficiently strong to resist mechanical impacts. (author). 5 refs., 41 figs., 9 tabs.

  10. A computational algorithm addressing how vessel length might depend on vessel diameter

    Science.gov (United States)

    Jing Cai; Shuoxin Zhang; Melvin T. Tyree

    2010-01-01

    The objective of this method paper was to examine a computational algorithm that may reveal how vessel length might depend on vessel diameter within any given stem or species. The computational method requires the assumption that vessels remain approximately constant in diameter over their entire length. When this method is applied to three species or hybrids in the...

  11. Vessel classification method based on vessel behavior in the port of Rotterdam

    NARCIS (Netherlands)

    Zhou, Y.; Daamen, W.; Vellinga, T.; Hoogendoorn, S.P.

    2015-01-01

    AIS (Automatic Identification System) data have proven to be a valuable source to investigate vessel behavior. The analysis of AIS data provides a possibility to recognize vessel behavior patterns in a waterway area. Furthermore, AIS data can be used to classify vessel behavior into several

  12. Enhanced antifungal effects of amphotericin B-TPGS-b-(PCL-ran-PGA nanoparticles in vitro and in vivo

    Directory of Open Access Journals (Sweden)

    Tang X

    2014-11-01

    Full Text Available Xiaolong Tang,1,2,* He Zhu,3,* Ledong Sun,4,* Wei Hou,2 Shuyu Cai,1 Rongbo Zhang,1 Feng Liu5 1Stem Cell Engineering Research Center, School of Medicine, Anhui University of Science and Technology, Huainan, People’s Republic of China; 2State Key Laboratory of Virology, Life Sciences College, Wuhan University, Wuhan, Hubei, People’s Republic of China; 3Institute of Skin Damage and Repair, General Hospital of Beijing Military Command, Beijing, People’s Republic of China; 4Department of Dermatology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China; 5Department of Anesthesiology, Children’s Hospital, Chongqing Medical University; Key Laboratory of Child Development and Disorders of the Ministry of Education, Chongqing, People’s Republic of China *These authors contributed equally to this work Background: Amphotericin B (AMB is a polyene antibiotic with broad spectrum antifungal activity, but its clinical toxicities and poor solubility limit the wide application of AMB in clinical practice. Recently, new drug-loaded nanoparticles (NPs – diblock copolymer D-α-tocopheryl polyethylene glycol 1000 succinate-b-poly(ε-caprolactone-ran-glycolide (PLGA-TPGS – have received special attention for their reduced toxicity, and increased effectiveness of drug has also been reported. This study aimed to develop AMB-loaded PLGA-TPGS nanoparticles (AMB-NPs and evaluate their antifungal effects in vitro and in vivo.Methods: AMB-NPs were prepared with a modified nanoprecipitation method and then characterized in terms of physical characteristics, in vitro drug release, stability, drug-encapsulation efficiency, and toxicity. Finally, the antifungal activity of AMB-NPs was investigated in vitro and in vivo.Results: AMB-NPs were stable and spherical, with an average size of around 110 nm; the entrapment efficacy was closed to 85%, and their release exhibited a typically biphasic pattern. The actual

  13. Nuclear reactor with a suspended vessel

    International Nuclear Information System (INIS)

    Lemercier, Guy.

    1977-01-01

    This invention relates to a nuclear reactor with a suspended vessel and applies in particular when this is a fast reactor, the core or active part of the reactor being inside the vessel and immersed under a suitable volume of flowing liquid metal to cool it by extracting the calories released by the nuclear fission in the fuel assemblies forming this core [fr

  14. Fabrication of Separator Demonstration Facility process vessel

    International Nuclear Information System (INIS)

    Oberst, E.F.

    1985-01-01

    The process vessel system is the central element in the Separator Development Facility (SDF). It houses the two major process components, i.e., the laser-beam folding optics and the separators pods. This major subsystem is the critical-path procurement for the SDF project. Details of the vaious parts of the process vessel are given

  15. Irradiation embrittlement of reactor vessel steels

    International Nuclear Information System (INIS)

    Bros, J.

    2000-01-01

    From the historical decision of closing the Yankee Rowe NPP because of the uncertainties on the level of reactor pressure vessel neutron embrittlement, this paper reviews the technical-scientist bases of the degradation phenomena, and refers to the evolution of reactor pressure vessel radiation surveillance programs. (Author)

  16. Ultrasound periodic inspections of reactor pressure vessels

    International Nuclear Information System (INIS)

    Haniger, L.

    1980-01-01

    Two versions are described of ultrasonic equipment for periodic inspections of reactor pressure vessels. One uses the principle of exchangeable programmators with solid-state logic while the other uses programmable logic with semiconductor memories. The equipment is to be used for inspections of welded joints on the upper part of the V-1 reactor pressure vessel. (L.O.)

  17. Elastic plastic buckling of elliptical vessel heads

    International Nuclear Information System (INIS)

    Alix, M.; Roche, R.L.

    1981-08-01

    The risks of buckling of dished vessel head increase when the vessel is thin walled. This paper gives the last results on experimental tests of 3 elliptical heads and compares all the results with some empirical formula dealing with elastic and plastic buckling

  18. Analyzing Vessel Behavior Using Process Mining

    NARCIS (Netherlands)

    Maggi, F.M.; Mooij, A.J.; Aalst, W.M.P. van der

    2013-01-01

    In the maritime domain, electronic sensors such as AIS receivers and radars collect large amounts of data about the vessels in a certain geographical area. We investigate the use of process mining techniques for analyzing the behavior of the vessels based on these data. In the context of maritime

  19. Metallurgy of steels for PWR pressure vessels

    International Nuclear Information System (INIS)

    Kepka, M.; Mocek, J.; Barackova, L.

    1980-01-01

    A survey and the chemical compositions are presented of reactor pressure vessel steels. The metallurgy is described of steel making for pressure vessels in Japan and the USSR. Both acidic and alkaline open-hearth steel is used for the manufacture of ingots. The leading world manufacturers of forging ingots for pressure vessels, however, exclusively use electric steel. Vacuum casting techniques are exclusively used. Experience is shown gained with the introduction of the manufacture of forging ingots for pressure vessels at SKODA, Plzen. The metallurgical procedure was tested utilizing alkaline open hearths, electric arc furnaces and facilities for vacuum casting of steel. Pure charge raw materials should be used for securing high steel purity. Prior to forging pressure vessel rings, not only should sufficiently big bottoms and heads be removed but also the ingot middle part should be scrapped showing higher contents of impurities and nonhomogeneous structure. (B.S.)

  20. Metallurgy of steels for PWR pressure vessels

    Energy Technology Data Exchange (ETDEWEB)

    Kepka, M; Mocek, J; Barackova, L [Skoda, Plzen (Czechoslovakia)

    1980-09-01

    A survey and the chemical compositions are presented of reactor pressure vessel steels. The metallurgy is described of steel making for pressure vessels in Japan and the USSR. Both acidic and alkaline open-hearth steel is used for the manufacture of ingots. The leading world manufacturers of forging ingots for pressure vessels, however, exclusively use electric steel. Vacuum casting techniques are exclusively used. Experience is shown gained with the introduction of the manufacture of forging ingots for pressure vessels at SKODA, Plzen. The metallurgical procedure was tested utilizing alkaline open hearths, electric arc furnaces and facilities for vacuum casting of steel. Pure charge raw materials should be used for securing high steel purity. Prior to forging pressure vessel rings, not only should sufficiently big bottoms and heads be removed but also the ingot middle part should be scrapped showing higher contents of impurities and nonhomogeneous structure.

  1. Nuclear reactor vessel fuel thermal insulating barrier

    Science.gov (United States)

    Keegan, C. Patrick; Scobel, James H.; Wright, Richard F.

    2013-03-19

    The reactor vessel of a nuclear reactor installation which is suspended from the cold leg nozzles in a reactor cavity is provided with a lower thermal insulating barrier spaced from the reactor vessel that has a hemispherical lower section that increases in volume from the center line of the reactor to the outer extent of the diameter of the thermal insulating barrier and smoothly transitions up the side walls of the vessel. The space between the thermal insulating harrier and the reactor vessel forms a chamber which can be flooded with cooling water through passive valving to directly cool the reactor vessel in the event of a severe accident. The passive inlet valve for the cooling water includes a buoyant door that is normally maintained sealed under its own weight and floats open when the cavity is Hooded. Passively opening steam vents are also provided.

  2. Method of burying vessel containing radioactive waste

    International Nuclear Information System (INIS)

    Koga, Yoshihito.

    1989-01-01

    A float having an inert gas sealed therein is attached to a tightly closed vessel containing radioactive wastes. The vessel is inserted and kept in a small hole for burying the tightly closed vessel in an excavated shaft in rocks such as of granite or rock salts, while filling bentonite as shielding material therearound. In this case, the float is so adjusted that the apparent specific gravity is made equal or nearer between the tightly closed vessel and the bentonite, so that the rightly closed vessel does not sink and cause direct contact with the rocks even if bentonite flows due to earthquakes, etc. This can prevent radioactivity contamination through water in the rocks. (S.K.)

  3. An experimental study on feasibility of ex-vessel cooling through the external guide vessel

    International Nuclear Information System (INIS)

    Kang, Kyoung-Ho; Kim, Jong-Hwan; Park, Rae-Jun; Kim, Sang-Baik

    2000-01-01

    This paper presents the results of a series of experiments for assessing the efficacy of ex-vessel cooling through the external guide vessel during a severe accident. Four tests were performed in the LAVA test facility at KAERI, varying the boundary conditions at the outer surface of the vessel. The first test was a dry condition test conducted without cooling the outside of the vessel. On the other hand, in the second test, the cooling of the vessel surface was produced by gravity-driven forced injection of water along the annular gap of 25 mm between the vessel and the external guide vessel. Water flow rate was about 0.85 kg/s and total mass of available water was 300 kg. For the evaluation of the water flow rate effect, the third test was performed with a pool type cooling in the annulus without any circulation of water. These two external cooling tests were performed under elevated pressure of about 1.6 MPa. Finally, the fourth test was conducted under atmospheric pressure to evaluate the effect of system pressure on boiling heat transfer characteristics. In the dry test and the pool type ex-vessel cooling test performed under atmospheric pressure, the vessel was failed by a melt penetration at about 40 degree upper position from the vessel bottom, which is coincident with the boundary of the Al 2 O 3 /Fe melt separated layers. On the other hand, in both of the ex-vessel cooling tests conducted under elevated pressure of about 1.6 MPa, the vessel didn't fail. Compared with the pool boiling test, the vessel experienced effective cooling due to the inlet flow in the forced flow test. Synthesized the results of the tests, it was shown that the heat removal with ex-vessel cooling through the guide vessel is feasible, but the additional evaluations should be performed to guarantee enough thermal margin. (author)

  4. Radiation embrittlement of PWR vessel supports

    International Nuclear Information System (INIS)

    Cheverton, R.D.; Robinson, G.C.; Pennell, W.E.; Nanstad, R.K.

    1989-01-01

    Several studies pertaining to radiation damage of PWR vessel supports were conducted between 1978 and 1987. During this period, apparently there was no reason to believe that low-temperature (<100 degree C) MTR embrittlement data were not appropriate for evaluating embrittlement of PWR vessel supports. However, late in 1986, data from the High Flux Isotope Reactor (HFIR) vessel surveillance program indicated that the embrittlement rates of the several HFIR vessel materials (A212-B, A350-LF3, A105-II) were substantially greater than anticipated on the basis of MTR data. Further evaluation of the HFIR data suggested that a fluence-rate effect was responsible for the apparent discrepancy, and shortly thereafter it became apparent that this rate effect was applicable to the evaluation of LWR vessel supports. As a result, the Nuclear Regulatory Commission (NRC) requested that the Oak Ridge National Laboratory (ORNL) evaluate the impact of the apparent embrittlement rate effect on the integrity of light-water-reactor (LWR) vessel supports. The purpose of the study was to provide an indication of whether the integrity of reactor vessel supports is likely to be challenged by radiation-induced embrittlement. The scope of the evaluation included correlation of the HFIR data for application to the evaluation of LWR vessel supports; a survey and cursory evaluation of all US LWR vessel support designs, selection of two plants for specific-plant evaluation, and a specific-plant evaluation of both plants to determine critical flaw sizes for their vessel supports. 19 refs., 8 figs., 2 tabs

  5. ITER vacuum vessel, in vessel components and plasma facing materials

    International Nuclear Information System (INIS)

    Ioki, Kimihiro; Enoeda, M.; Federici, G.

    2007-01-01

    Design of the NB ports including duct liners under heat loads of the neutral beams has been developed. Design of the in-wall shielding has been developed in more details considering the supporting structure and the assembly method. The ferromagnetic inserts have previously not been installed in the outboard midplane region due to irregularity caused by the tangential ports for NB injection. Due to this configuration, the maximum ripple is relatively large (∝1 %) in a limited region of the plasma and the toroidal field flux lines fluctuate ∝10 mm in the FW region. To avoid these problems, additional ferromagnetic inserts are to be installed in the equatorial port region. Detailed studies were carried out on the ITER vacuum vessel to define appropriate codes and standards in the context of the ITER licensing in France. A set of draft documents regarding the ITER vacuum vessel structural code were prepared including an RCC-MR Addendum for the ITER VV with justified exceptions or modifications. The main deviation from the base Code is the extensive use of UT in lieu of radiography for the volumetric examination of all one-side access welds of the outer shell and field joint. The procurement allocation of blanket modules among 6 parties was fixed and the blanket module design has progressed in cooperation with parties. Fabrication of mock-ups for prequalification testing is under way and the tests will be performed in 2007-2008. Development of new beryllium materials is progressing in China and Russia. The ITER limiters will be installed in equatorial ports at two toroidal locations. The limiter plasma-facing surface protrudes ∝8 cm from the FW during the start-up and shutdown phase. In the new limiter concept, the limiters are retracted by ∝8 cm during the plasma flat top phase. This concept gives important advantages; (i) mitigation of the particle and heat loads due to disruptions, ELMs and blobs, (ii) improvement of the power coupling with the ICRH antenna

  6. Reactor pressure vessel. Status report

    International Nuclear Information System (INIS)

    Elliot, B.J.; Hackett, E.M.; Lee, A.D.

    1996-10-01

    This report describes the issues raised as a result of the staffs review of Generic Letter (GL) 92-01, Revision 1, responses and plant-specific reactor pressure vessel (RPV) assessments and the actions taken or work in progress to address these issues. In addition, the report describes actions taken by the staff and the nuclear industry to develop a thermal annealing process for use at U.S. commercial nuclear power plants. This process is intended to be used as a means of mitigating the effects of neutron radiation on the fracture toughness of RPV materials. The Nuclear Regulatory Commission (NRC) issued GL 92-01, Revision 1, Supplement 1, to obtain information needed to assess compliance with regulatory requirements and licensee commitments regarding RPV integrity. GL 92-01, Revision 1, Supplement 1, was issued as a result of generic issues that were raised in the NRC staff's reviews of licensee responses to GL 92-01, Revision 1, and plant-specific RPV evaluations. In particular, an integrated review of all data submitted in response to GL 92-01, Revision 1, indicated that licensees may not have considered all relevant data in their RPV assessments. This report is representative of submittals to and evaluations by the staff as of September 30, 1996. An update of this report will be issued at a later date

  7. 78 FR 40891 - Revisions to the Export Administration Regulations: Military Vehicles; Vessels of War...

    Science.gov (United States)

    2013-07-08

    ... Vehicles; Vessels of War; Submersible Vessels, Oceanographic Equipment; Related Items; and Auxiliary and... Regulations: Military Vehicles; Vessels of War; Submersible Vessels, Oceanographic Equipment; Related Items... military vehicles and related items; vessels of war and related items; submersible vessels, oceanographic...

  8. Design of the ITER vacuum vessel

    International Nuclear Information System (INIS)

    Ioki, K.; Johnson, G.; Shimizu, K.; Williamson, D.

    1995-01-01

    The ITER vacuum vessel is a major safety barrier and must support electromagnetic loads during plasma disruptions and vertical displacement events (VDE) and withstand plausible accidents without losing confinement.The vacuum vessel has a double wall structure to provide structural and electrical continuity in the toroidal direction. The inner and outer shells and poloidal stiffening ribs between them are joined by welding, which gives the vessel the required mechanical strength. The space between the shells will be filled with steel balls and plate inserts to provide additional nuclear shielding. Water flowing in this space is required to remove nuclear heat deposition, which is 0.2-2.5% of the total fusion power. The minor and major radii of the tokamak are 3.9 m and 13 m respectively, and the overall height is 15 m. The total thickness of the vessel wall structure is 0.4-0.7 m.The inboard and outboard blanket segments are supported from the vacuum vessel. The support structure is required to withstand a large total vertical force of 200-300 MN due to VDE and to allow for differential thermal expansion.The first candidate for the vacuum vessel material is Inconel 625, due to its higher electric resistivity and higher yield strength, even at high temperatures. Type 316 stainless steel is also considered a vacuum vessel material candidate, owing to its large database and because it is supported by more conventional fabrication technology. (orig.)

  9. Assessment of reactor vessel integrity (ARVI)

    Energy Technology Data Exchange (ETDEWEB)

    Sehgal, B.R. E-mail: sehgal@ne.kth.se; Theerthan, A.; Giri, A.; Karbojian, A.; Willschuetz, H.G.; Kymaelaeinen, O.; Vandroux, S.; Bonnet, J.M.; Seiler, J.M.; Ikkonen, K.; Sairanen, R.; Bhandari, S.; Buerger, M.; Buck, M.; Widmann, W.; Dienstbier, J.; Techy, Z.; Kostka, P.; Taubner, R.; Theofanous, T.; Dinh, T.N

    2003-04-01

    The cost-shared project ARVI (assessment of reactor vessel integrity) involves a total of nine organisations from Europe and USA. The objective of the ARVI Project is to resolve the safety issues that remain unresolved for the melt vessel interaction phase of the in-vessel progression of a severe accident. The work consists of experiments and analysis development. Four tests were performed in the EC-FOREVER Programme, in which failure was achieved in-vessels employing the French pressure vessel steel. The tests were analysed with the commercial code ANSYS-Multiphysics, and the codes SYSTUS+ and PASULA, and quite good agreement was achieved for the failure location. Natural convection experiments in stratified pools have been performed in the SIMECO and the COPO facilities, which showed that much greater heat is transferred downwards for immiscible layers or before layers mix. A model for gap cooling and a set of simplified models for the system codes have been developed. MVITA code calculations have been performed for the Czech and Hungarian VVERs, towards evaluation of the in-vessel melt retention accident management scheme. Tests have been performed at the ULPU facility with organised flow for vessel external cooling. Considerable enhancement of the critical heat flux (CHF) was obtained. The ARVI Project has reached the halfway stage. This paper presents the results obtained thus far from the project.

  10. Flexible Composite-Material Pressure Vessel

    Science.gov (United States)

    Brown, Glen; Haggard, Roy; Harris, Paul A.

    2003-01-01

    A proposed lightweight pressure vessel would be made of a composite of high-tenacity continuous fibers and a flexible matrix material. The flexibility of this pressure vessel would render it (1) compactly stowable for transport and (2) more able to withstand impacts, relative to lightweight pressure vessels made of rigid composite materials. The vessel would be designed as a structural shell wherein the fibers would be predominantly bias-oriented, the orientations being optimized to make the fibers bear the tensile loads in the structure. Such efficient use of tension-bearing fibers would minimize or eliminate the need for stitching and fill (weft) fibers for strength. The vessel could be fabricated by techniques adapted from filament winding of prior composite-material vessels, perhaps in conjunction with the use of dry film adhesives. In addition to the high-bias main-body substructure described above, the vessel would include a low-bias end substructure to complete coverage and react peak loads. Axial elements would be overlaid to contain damage and to control fiber orientation around side openings. Fiber ring structures would be used as interfaces for connection to ancillary hardware.

  11. Offshore wind transport and installation vessel

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    The initial objective of the project was to complete a feasibility study to determine the viability of an innovative transportation vessel to be deployed in the installation of offshore wind farms. This included the feasibility of providing a stable-working platform that can be used in harsh offshore environments. A study of current installation contractors and their installation equipment was used to provide a preliminary specification for the installation vessel. A typical barge was selected and a number of hydrodynamic analyses were carried out in order to establish it's on course and operational stability. The analysis proved the stability of the vessel during operation was critical and that in order to utilise the crane's full potential a stabilisation system must be employed. The main aim of the work to date was to establish whether it was feasible to use a stabilisation system on the installation vessel. The spud leg FEED study established that it was feasible to use spud legs to stabilise the vessel. In order to achieve the degree of stability required it is necessary to lift the vessel completely out of the water. This was not the original aim of the study but due to the external loads on the hull it was the only viable option. Lifting the vessel out of the water results in the legs and leg casings becoming very large. This has a number of consequences for the final design. Due to large loads on the legs spud cans must be used to avoid bottom penetration, the spud cans increase the draft of the vessel by 2m. The large loads require larger winches and more reeving to be used, this results in larger pumps and motors, all of which have to be housed. The stabilisation system has been proved to be feasible for a large installation vessel, the cost and physical size are however more excessive than first anticipated. (Author)

  12. Reactor vessel using metal oxide ceramic membranes

    Science.gov (United States)

    Anderson, Marc A.; Zeltner, Walter A.

    1992-08-11

    A reaction vessel for use in photoelectrochemical reactions includes as its reactive surface a metal oxide porous ceramic membrane of a catalytic metal such as titanium. The reaction vessel includes a light source and a counter electrode. A provision for applying an electrical bias between the membrane and the counter electrode permits the Fermi levels of potential reaction to be favored so that certain reactions may be favored in the vessel. The electrical biasing is also useful for the cleaning of the catalytic membrane.

  13. A study of reactor vessel integrity assessment

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jae Hoon [Korea Institute of Nuclear Safety, Taejon (Korea, Republic of); Kim, Jong Kyung; Shin, Chang Ho; Seo, Bo Kyun [Hanyang Univ., Seoul (Korea, Republic of)

    1999-02-15

    The fast neutron fluence at the Reactor Pressure Vessel(RPV) of KNGR designed for 60 years lifetime was calculated by full-scope Monte Carlo simulation for reactor vessel integrity assessment. KNGR core geometry was modeled on a three-dimensional representation of the one-sixteenth of the reactor in-vessel component. Each fuel assemblies were modeled explicitly, and each fuel pins were axially divided into 5 segments. The maximum flux of 4.3 x 10{sup 10} neutrons/cm{sup 2}. sec at the RPV was obtained by tallying neutrons crossing the beltline of inner surface of the RPV.

  14. Structural Analysis of the NCSX Vacuum Vessel

    International Nuclear Information System (INIS)

    Fred Dahlgren; Art Brooks; Paul Goranson; Mike Cole; Peter Titus

    2004-01-01

    The NCSX (National Compact Stellarator Experiment) vacuum vessel has a rather unique shape being very closely coupled topologically to the three-fold stellarator symmetry of the plasma it contains. This shape does not permit the use of the common forms of pressure vessel analysis and necessitates the reliance on finite element analysis. The current paper describes the NCSX vacuum vessel stress analysis including external pressure, thermal, and electro-magnetic loading from internal plasma disruptions and bakeout temperatures of up to 400 degrees centigrade. Buckling and dynamic loading conditions are also considered

  15. Vessel Sewage Discharges: Statutes, Regulations, and Related Laws and Treaties

    Science.gov (United States)

    Vessel sewage discharges can be regulated under multiple statutes, regulations, and laws/treaties, including the Clean Water Act, Title XIV, MARPOL Annex IV and the Vessel General Permit. This page describes how these are applied to vessel sewage.

  16. Evaluation for In-Vessel Retention Capabilities with In-Vessel Injection and External Reactor Vessel Cooling

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jeong Seong; Ryu, In Chul; Moon, Young Tae [KEPCO Engineering and Construction Co. Ltd., Deajeon (Korea, Republic of)

    2016-10-15

    If the accident has not progressed to the point of substantial changes in the core geometry, establishing adequate cooling is as straightforward as re-establishing flow through the reactor core. However, if the accident has progressed to the point where the core geometry is substantially altered as a result of material melting and relocation, as was the case in the TMI-2 accident, the means of cooling the debris are not as straightforward. From this time on, the reactor core was either completely or nearly covered by water, with high pressure injection flow initiated shortly after three hours into the accident. However, the core debris was not coolable in this configuration and a substantial quantity of molten core material drained into the bypass region, with approximately twenty metric tons of molten debris draining into the reactor pressure vessel (RPV) lower head. Hence, the core configuration developed at approximately three hours into the accident was not coolable, even submerged in water. The purpose of this paper is to evaluate in-vessel retention capabilities with in-vessel injection (IVI) and external reactor vessel cooling (ERVC) available in a reactor application by using the integrated severe accident analysis code. The MAAP5 models were improved to facilitate evaluation of the in-vessel retention capability of APR1400. In-vessel retention capabilities have been analyzed for the APR1400 using the MAAP5.03 code. The results show that in-vessel retention is feasible when in-vessel injection is initiated within a relatively short time frame under the simulation condition used in the present study.

  17. Evaluation for In-Vessel Retention Capabilities with In-Vessel Injection and External Reactor Vessel Cooling

    International Nuclear Information System (INIS)

    Lee, Jeong Seong; Ryu, In Chul; Moon, Young Tae

    2016-01-01

    If the accident has not progressed to the point of substantial changes in the core geometry, establishing adequate cooling is as straightforward as re-establishing flow through the reactor core. However, if the accident has progressed to the point where the core geometry is substantially altered as a result of material melting and relocation, as was the case in the TMI-2 accident, the means of cooling the debris are not as straightforward. From this time on, the reactor core was either completely or nearly covered by water, with high pressure injection flow initiated shortly after three hours into the accident. However, the core debris was not coolable in this configuration and a substantial quantity of molten core material drained into the bypass region, with approximately twenty metric tons of molten debris draining into the reactor pressure vessel (RPV) lower head. Hence, the core configuration developed at approximately three hours into the accident was not coolable, even submerged in water. The purpose of this paper is to evaluate in-vessel retention capabilities with in-vessel injection (IVI) and external reactor vessel cooling (ERVC) available in a reactor application by using the integrated severe accident analysis code. The MAAP5 models were improved to facilitate evaluation of the in-vessel retention capability of APR1400. In-vessel retention capabilities have been analyzed for the APR1400 using the MAAP5.03 code. The results show that in-vessel retention is feasible when in-vessel injection is initiated within a relatively short time frame under the simulation condition used in the present study

  18. Prediction of dosage-based parameters from the puff dispersion of airborne materials in urban environments using the CFD-RANS methodology

    Science.gov (United States)

    Efthimiou, G. C.; Andronopoulos, S.; Bartzis, J. G.

    2018-02-01

    One of the key issues of recent research on the dispersion inside complex urban environments is the ability to predict dosage-based parameters from the puff release of an airborne material from a point source in the atmospheric boundary layer inside the built-up area. The present work addresses the question of whether the computational fluid dynamics (CFD)-Reynolds-averaged Navier-Stokes (RANS) methodology can be used to predict ensemble-average dosage-based parameters that are related with the puff dispersion. RANS simulations with the ADREA-HF code were, therefore, performed, where a single puff was released in each case. The present method is validated against the data sets from two wind-tunnel experiments. In each experiment, more than 200 puffs were released from which ensemble-averaged dosage-based parameters were calculated and compared to the model's predictions. The performance of the model was evaluated using scatter plots and three validation metrics: fractional bias, normalized mean square error, and factor of two. The model presented a better performance for the temporal parameters (i.e., ensemble-average times of puff arrival, peak, leaving, duration, ascent, and descent) than for the ensemble-average dosage and peak concentration. The majority of the obtained values of validation metrics were inside established acceptance limits. Based on the obtained model performance indices, the CFD-RANS methodology as implemented in the code ADREA-HF is able to predict the ensemble-average temporal quantities related to transient emissions of airborne material in urban areas within the range of the model performance acceptance criteria established in the literature. The CFD-RANS methodology as implemented in the code ADREA-HF is also able to predict the ensemble-average dosage, but the dosage results should be treated with some caution; as in one case, the observed ensemble-average dosage was under-estimated slightly more than the acceptance criteria. Ensemble

  19. Expression of RAN, ZHX-2, and CHC1L genes in multiple myeloma patients and in myeloma cell lines treated with HDAC and Dnmts inhibitors

    Czech Academy of Sciences Publication Activity Database

    Legartová, Soňa; Harničarová, Andrea; Bártová, Eva; Hájek, R.; Pour, L.; Kozubek, Stanislav

    2010-01-01

    Roč. 57, č. 5 (2010), s. 482-487 ISSN 0028-2685 R&D Projects: GA MŠk ME 919; GA ČR(CZ) GAP302/10/1022 Grant - others:GA MŠk(CZ) LC06027; GA MŠk(CZ) LC535 Program:LC; LC Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702 Keywords : multiple myeloma * RAN * ZHX-2 Subject RIV: BO - Biophysics Impact factor: 1.449, year: 2010

  20. İran Mitolojisinin İslam Devrimindeki Rolü & Humeyni ve Şah’ın Söylemlerinin Analizi

    Directory of Open Access Journals (Sweden)

    Fatih TİRYAKİ

    2015-09-01

    Full Text Available İran tarihinde köklü değişimler meydana getiren İran İslam devrimi birçok farklı açıdan analiz edilmiş olsa da bu analizlerin pek azı devrimi mitolojik çerçeve ile temellendirmektedir. Böylesine köklü bir devletin geçmişle olan bağlarının her daim canlı olduğu gerçeğini varsayar isek devrim sürecinde de halkın bilinçaltındaki mitolojik inanışların önemli bir payı olduğunu söylemek mümkündür. Bu bilgiler ışığında biz bu çalışmamızda İran mitolojisinin devrime olan etkilerini ve hem Şah’ın hem de Humeyni’nin bu dönemdeki söylemlerini mitolojik bir perspektiften değerlendireceğiz. Bunu yaparken de 1953 Musaddık devrimini milat olarak kabul edip bu tarihten devrime kadar geçen kırılma noktalarını kronolojik bir sıra ile anakronizme kaçmadan incelerken olayları son tahlilde mitoloji ile ilişkilendireceğiz. Sonuç bölümünde ise devrim ile esasında çok fazla şeyin değişmediğini, değişenin yalnızca meşruiyetini ve İran halkının baba figürü olma özelliğini kaybeden Şah’ın yerine halkçı ve sözde fundemantalist söylemleri ile halkı derinden etkileyen yeni baba figürü Humeyni’nin geldiği tespitlerinde bulunacağız

  1. Simulation of In-Vessel Corium Retention through External Reactor Vessel Cooling for SMART using SIMPLE

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Jin-Sung; Son, Donggun; Park, Rae-Joon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    Thermal load analysis from the corium pool to the outer reactor vessel in the lower plenum of the reactor vessel is necessary to evaluate the effect of the IVR-ERVC during a severe accident for SMART. A computational code called SIMPLE (Sever Invessel Melt Progression in Lower plenum Environment) has been developed for analyze transient behavior of molten corium in the lower plenum, interaction between corium and coolant, and heat-up and ablation of reactor vessel wall. In this study, heat load analysis of the reactor vessel for SMART has been conducted using the SIMPLE. Transient behavior of the molten corium in the lower plenum and IVR-ERVC for SMART has been simulated using SIMPLE. Heat flux from the corium pool to the outer reactor vessel is concentrated in metallic layer by the focusing effect. As a result, metallic layer shows higher temperature than the oxidic layer. Also, vessel wall of metallic layer has been ablated by the high in-vessel temperature. Ex-vessel temperature of the metallic layer was maintained 390 K and vessel thickness was maintained 14 cm. It means that the reactor vessel integrity is maintained by the IVR-ERVC.

  2. Device of supporting a vacuum plasma vessel

    International Nuclear Information System (INIS)

    Kanoi, Minoru; Hori, Yasuro.

    1980-01-01

    Purpose: To improve the earthquake-resistance of a vacuum plasma vessel by equalizing the natural vibrations of a vibrating system formed by supporting mechanisms of the respective sectors of the vessel. Constitution: The vacuum plasma vessel is constructed of bellows interposed among a plurality of thick sector-like rings and the rings, which are respectively supported by supporting mechanisms. Thus, the vibrating systems are divided into the rings interposed with the bellows, arms as the supporting mechanisms, and posts. The natural vibrations of these vibrating systems are equalized to each other by suitably adjusting the configurations and the sized of the arms and the posts or the weight or the like of the rings. Therefore, the respective rings become vibrated at the natural vibrations equal to each other so as to largely reduce the stresses produced at both ends of the bellows. Accordingly, it can remarkably improve the earthquake-resistance of the entire plasma vessel. (Sekiya, K.)

  3. 2013 Gulf of Mexico Vessel Tracklines

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  4. 2011 Gulf of Mexico Vessel Tracklines

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  5. Pressure vessel for a BWR type reactor

    International Nuclear Information System (INIS)

    Shimamoto, Yoshiharu.

    1980-01-01

    Purpose: To prevent the retention of low temperature water and also prevent the thermal fatigue of the pressure vessel by making large the curvature radius of a pressure vessel of a feed water sparger fitting portion and accelerating the mixing of low-temperature water at the feed water sparger base and in-pile hot water. Constitution: The curvature radius of the corner of the feed water sparger fitting portion in a pressure vessel is formed largely. In-pile circulating water infiltrates up to the base portion of the feed water sparger to carry outside low-temperature water at the base part, which is mixed with in-pile hot water. Accordingly, low temperature water does not stay at the base portion of the feed water sparger and generation of thermal fatigue in the pressure vessel can be prevented and the safety of the BWR type reactor can be improved. (Yoshino, Y.)

  6. 2013 Pleasure Craft and Sailing Vessel Density

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  7. Large Pelagic Logbook Set Survey (Vessels)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains catch and effort for fishing trips that are taken by vessels with a Federal permit issued for the swordfish and sharks under the Highly...

  8. Large Pelagic Logbook Trip Survey (Vessels)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains catch and effort for fishing trips that are taken by vessels with a Federal permit issued for the swordfish and sharks under the Highly...

  9. Initial conditioning of the TFTR vacuum vessel

    International Nuclear Information System (INIS)

    Dylla, H.F.; Blanchard, W.R.; Krawchuk, R.B.; Hawryluk, R.J.; Owens, D.K.

    1984-01-01

    We report on the initial conditioning of the Tokamak Fusion Test Reactor (TFTR) vacuum vessel prior to the initiation of first plasma discharges, and during subsequent operation with high power ohmically-heated plasmas. Following evacuation of the 86 m 3 vessel with the 10 4 1/s high vacuum pumping system, the vessel was conditioned by a 15 A dc glow discharge in H 2 at a pressure of 5 mTorr. Rapid-pulse discharge cleaning was used subsequently to preferentially condition the graphite plasma limiters. The effectiveness of the discharge cleaning was monitored by measuring the exhaust rates of the primary discharge products (CO/C 2 H 4 , CH 4 , and H 2 O). After 175 hours of glow discharge treatment, the equivalent of 50 monolayers of C and O was removed from the vessel, and the partial pressures of impurity gases were reduced to the range of 10 -9 -10 -10 Torr

  10. 75 FR 56015 - Vessel Inspection Alternatives

    Science.gov (United States)

    2010-09-15

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard 46 CFR Part 8 Vessel Inspection Alternatives CFR... Certificate; (ii) International Tonnage Certificate; (iii) Cargo Ship Safety Construction Certificate; (iv) Cargo Ship Safety Equipment Certificate; and (v) International Oil Pollution Prevention Certificate; and...

  11. Qualification of anticorrosive coatings in nuclear vessels

    International Nuclear Information System (INIS)

    Perez Flores, C.

    1985-01-01

    Test qualifications of the behavior of anticorrosive coating systems used in nuclear vessels in service and under the accident conditions of radiation decontamination, steam chemical resistance, thermal conductivity, weathering accelerated aging are presented and discussed. (author)

  12. Sealing analysis for nuclear vessels of PWR

    International Nuclear Information System (INIS)

    Qu Jiadi; Dou Yikang

    1988-01-01

    The fundamental equations of sealing analysis for vessels are given and a computer program named SMEC, which considers the change of stud loading, the elastic contact between flange mating surfaces and the transient thermal effects, is developed accordingly. The SMEC is verified by several test. On the basis of analysis, a new concept of classifying vessels into three types according to increasing or decreasing of bolt loading with increasing pressure is suggested. Type-A vessel is that in which the bolt loading increases monotonically with increasing pressure, while in type-B, the bolt loading decreases monotonically, and in type-C, the bolt loading changes nonmonotonically. It is important for vessel design to distinguish the types through analysis. The sealing mechanism is also discussed

  13. Swarm Manipulation of Large Surface Vessels

    National Research Council Canada - National Science Library

    Smith, Erik T

    2007-01-01

    The goal of this Trident project was to develop an independent control scheme to allow a team of autonomous tugboats to move a large disabled vessel, such as a barge, to a desired position and orientation...

  14. Some aspects of reactor pressure vessel integrity

    International Nuclear Information System (INIS)

    Korosec, D.; Vojvodic, G.J.

    1996-01-01

    Reactor pressure vessel of the pressurized water reactor nuclear power plant is the subject of extreme interest due to the fact that presents the pressure boundary of the reactor coolant system, which is under extreme thermal, mechanical and irradiation effects. Reactor pressure vessel by itself prevents the release of fission products to the environment. Design, construction and in-service inspection of such component is governed by strict ASME rules and other forms of administrative control. The reactor pressure vessel in nuclear power plant Kriko is designed and constructed in accordance with related ASME rules. The in-service inspection program includes all requests presented in ASME Code section XI. In the present article all major requests for the periodic inspections of reactor pressure vessel and fracture mechanics analysis are discussed. Detailed and strict fulfillment of all prescribed provisions guarantee the appropriate level of nuclear safety. (author)

  15. Atlantic Marine Mammal Assessment Vessel Surveys

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These data sets are a compilation of large vessel surveys for marine mammal stock assessments in South Atlantic (Florida to Maryland) waters from 1994 to the...

  16. Method to moor an offshore operating vessel

    Energy Technology Data Exchange (ETDEWEB)

    Flory, J.F.

    1983-01-24

    A vessel such as a storage vessel is permanently moored, by means such as a yoke pivoted on the forecastle of the vessel, to a mooring leg, e.g. a riser or anchor chain, which is attached to a base located on the ocean floor. Mounted on the vessel is tension exsisting means, for example, counterweights, springs, winches, or the like, operably connected with the mooring leg for applying tension thereto such as by lifting the yoke. The top of the mooring leg is connected to the end of the yoke through a mooring swivel and a gimbaled mooring table or a universal joint. A fluid swivel may be located above the mooring table or about a load-carrying shaft connected to the mooring leg. 8 drawings.

  17. Caribbean Marine Mammal Assessment Vessel Surveys

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These data sets are a compilation of large vessel surveys for marine mammal stock assessments in Caribbean waters conducted during 2000-2001. These surveys were...

  18. Advanced toroidal facility vaccuum vessel stress analyses

    International Nuclear Information System (INIS)

    Hammonds, C.J.; Mayhall, J.A.

    1987-01-01

    The complex geometry of the Advance Toroidal Facility (ATF) vacuum vessel required special analysis techniques in investigating the structural behavior of the design. The response of a large-scale finite element model was found for transportation and operational loading. Several computer codes and systems, including the National Magnetic Fusion Energy Computer Center Cray machines, were implemented in accomplishing these analyses. The work combined complex methods that taxed the limits of both the codes and the computer systems involved. Using MSC/NASTRAN cyclic-symmetry solutions permitted using only 1/12 of the vessel geometry to mathematically analyze the entire vessel. This allowed the greater detail and accuracy demanded by the complex geometry of the vessel. Critical buckling-pressure analyses were performed with the same model. The development, results, and problems encountered in performing these analyses are described. 5 refs., 3 figs

  19. Caribbean ST Thomas trap Logbook Survey (Vessels)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains catch (landed catch) and effort for fishing trips made by vessels fishing in St. Thomas. The catch and effort data for the entire trip are...

  20. 2011 Pleasure Craft Sailing Vessel Density

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  1. Final processing vessel for radioactive waste

    International Nuclear Information System (INIS)

    Tejima, Takaya; Hiraki, Akimitsu.

    1989-01-01

    An inorganic inner layer comprising dense inorganic material such as organic polymer-impregnated concretes is formed to about 10 - 50 mm in average thickness at the inside of a metal vessel. Further, the surface of the vessel is formed as a flat surface with no or only small reinforcing protrusions. Thus, if the final processing vessel should be dropped during transportation or handling by mistake, since impact shocks do not concentrate to protrusions as usual, no local stress concentration occurs to the inorganic inner liner layer. Accordingly, the risk of rapture can be reduced greatly. Further, since impact shock resistance layer put between the metal vessel and the inorganic inner liner layer absorbs shocks, a further sufficient strength can be obtained against dropping accident. (T.M.)

  2. Fatigue evaluation in reactor vessel components

    International Nuclear Information System (INIS)

    Mattar Neto, Miguel; Miranda, Carlos A. de J.

    1994-01-01

    This paper presents a sequence of increasing complexity forms of evaluating fatigue damage of nuclear pressure vessel components caused by cycling loadings. Examples are included in order to illustrate such procedures. (author)

  3. MRA of fibromuscular dysplasia in cervical vessels

    International Nuclear Information System (INIS)

    Link, J.; Steffens, J.C.; Mueller-Huelsbeck, S.; Brossmann, J.; Heller, M.

    1996-01-01

    In 386 selective angiograms of cervical vessels fibromuscular dysplasia was revealed in 4 female patients in the age of 30-54 years. FMD was located in the carotid artery (n=5) and in the vertebral artery (n=2) with a total of 8 lesions. 6/8 of the lesions of the seven cervical vessels were located typically in the mid cervical portion of the vessels and 2/6 lesions were located in the atlas loop of the vertebral artery. 4 lesions showed moderate stenosis and 4 vessels showed only mild stenosis. These patterns which demonstrated the typical morphology of fibromuscular dysplasia with alternating irregular zones of widening and narrowing were evaluated well with MR angiography, the others were missed. (orig./MG) [de

  4. A case of small vessel vasculitis

    Directory of Open Access Journals (Sweden)

    Madhulika Mahashabde

    2014-01-01

    We are reporting a case of un-specified small vessel vasculitis, which was diagnosed on the basis of positive perinuclear anti neutrophil cytoplasmic antibodies (ANCA P MPO done by Enzyme Linked Immunosorbent Assay (ELISA.

  5. Subconjunctival Hemorrhage (Broken Blood Vessel in Eye)

    Science.gov (United States)

    Subconjunctival hemorrhage (broken blood vessel in eye) Overview A subconjunctival hemorrhage (sub-kun-JUNK-tih-vul HEM-uh-ruj) ... may not even realize you have a subconjunctival hemorrhage until you look in the mirror and notice ...

  6. TMI-2 Vessel Investigation Project integration report

    Energy Technology Data Exchange (ETDEWEB)

    Wolf, J. R.; Rempe, J. L.; Stickler, L. A.; Korth, G. E.; Diercks, D. R.; Neimark, L. A.; Akers, D W; Schuetz, B. K.; Shearer, T L; Chavez, S. A.; Thinnes, G. L.; Witt, R. J.; Corradini, M L; Kos, J. A. [EG and G Idaho, Inc., Idaho Falls, ID (United States)

    1994-03-01

    The Three Mile Island Unit 2 (TMI-2) Vessel Investigation Project (VIP) was an international effort that was sponsored by the Nuclear Energy Agency of the Organization for Economic Cooperation and Development. The primary objectives of the VIP were to extract and examine samples from the lower head and to evaluate the potential modes of failure and the margin of structural integrity that remained in the TMI-2 reactor vessel during the accident. This report presents a summary of the major findings and conclusions that were developed from research during the VIP. Results from the various elements of the project are integrated to form a cohesive understanding of the vessel`s condition after the accident.

  7. Wine vessels (Vasa vinaria in roman law

    Directory of Open Access Journals (Sweden)

    Aličić Samir

    2017-01-01

    Full Text Available The notion of 'wine vessels' in Roman law comprises all the winecontaining recipients. There is no legal standardization of wine vessels by means of volume, and although the terms amphora, urna and culleus are used to designate both the vessels and the units of measure, these are two different meanings of the terms. In regard of the question, whether the vessels make appurtenance of the wine, jurisprudents of proculean school divided them in two categories. In the first category are those that follow legal status of wine, usually amphoras and other jars (cadi which are used for 'packaging', i. e. 'bottling' of the wine. The second category make mostly vats (cuppae and ceramic cisterns (dolia, which don't follow legal status of wine, making instead part of farming equipment of a landed property (instrumentum fundi and it's appurtenance. But, the roman jurists are not consistent regarding criteria for distinguishing these two categories.

  8. Conjugate heat transfer analysis for in-vessel retention with external reactor vessel cooling

    International Nuclear Information System (INIS)

    Park, Jong-Woon; Bae, Jae-ho; Song, Hyuk-Jin

    2016-01-01

    Highlights: • A conjugate heat transfer analysis method is applied for in-vessel corium retention. • 3D heat diffusion has a formidable effect in alleviating focusing heat load from metallic layer. • The focusing heat load is decreased by about 2.5 times on the external surface. - Abstract: A conjugate heat transfer analysis method for the thermal integrity of a reactor vessel under external reactor vessel cooling conditions is developed to resolve light metal layer focusing effect issue for in-vessel retention. The method calculates steady-state three-dimensional temperature distribution of a reactor vessel using coupled conjugate heat transfer between in-vessel three-layered stratified corium (metallic pool, oxide pool and heavy metal and polar-angle dependent boiling heat transfer at the outer surface of a reactor vessel). The three-layer corium heat transfer model is utilizing lumped-parameter thermal-resistance circuit method. For the ex-vessel boiling boundary conditions, nucleate, transition and film boiling are considered. The thermal integrity of a reactor vessel is addressed in terms of heat flux at the outer-most nodes of the vessel and remaining thickness profile. The vessel three-dimensional heat conduction is validated against a commercial code. It is found that even though the internal heat flux from the metal layer goes far beyond critical heat flux (CHF) the heat flux from the outermost nodes of the vessel may be maintained below CHF due to massive vessel heat diffusion. The heat diffusion throughout the vessel is more pronounced for relatively low heat generation rate in an oxide pool. Parametric calculations are performed considering thermal conditions such as peak heat flux from a light metal layer, heat generation in an oxide pool and external boiling conditions. The major finding is that the most crucial factor for success of in-vessel retention is not the mass of the molten light metal above the oxide pool but the heat generation rate

  9. Results of reactor pressure vessels ISI

    International Nuclear Information System (INIS)

    Cepcek, S.

    1994-01-01

    To find out the possible influence of the annealing process to reactor pressure vessel integrity, a large in-service inspection programme has been implemented as an associated activity to reactor pressure vessel annealing. In this paper the approach to the RPV in-service inspection is shown. Also, the main results and conclusions following in-service inspection are presented. (author). 3 refs, 1 fig

  10. Anatomically corrected transposition of great vessels

    International Nuclear Information System (INIS)

    Ivanitskij, A.V.; Sarkisova, T.N.

    1989-01-01

    The paper is concerned with the description of rare congenital heart disease: anatomically corrected malposition of major vessels in a 9-mos 24 day old girl. The diagnosis of this disease was shown on the results of angiocardiography, concomitant congenital heart diseases were descibed. This abnormality is characterized by common atrioventricular and ventriculovascular joints and inversion position of the major vessels, it is always attended by congenital heart diseases. Surgical intervention is aimed at the elimination of concomitant heart dieseases

  11. Analysis of nuclear reactor pressure vessel flanges

    International Nuclear Information System (INIS)

    Oliveira, C.A.N. de; Augusto, O.B.

    1985-01-01

    This work proposes a methodology for the structural analysis of high diameter nuclear reactor pressure vessel flanges. In the analysis the vessel is divided into shell-of-revolution elements, the flanges are represented by rigid rings, and the bolts are treated as beams. The flexibility method is used for solving the problem, and the results are compared with results obtained by the finite element method. (Author) [pt

  12. Reactor vessel nozzle cracks: a photoelastic study

    International Nuclear Information System (INIS)

    Smith, C.W.

    1979-01-01

    A method consisting of a marriage between the ''frozen stress'' photoelastic approach and the local stress field equations of linear elastic fracture mechanics for estimating stress intensity factor distributions in three dimensional, finite cracked body problems is reviewed and extensions of the method are indicated. The method is then applied to the nuclear reactor vessel nozzle corner crack problem for both Intermediate Test Vessel and Boiling Water Reactor geometries. Results are compared with those of other investigators. 35 refs

  13. Proof testing of an explosion containment vessel

    Energy Technology Data Exchange (ETDEWEB)

    Esparza, E.D. [Esparza (Edward D.), San Antonio, TX (United States); Stacy, H.; Wackerle, J. [Los Alamos National Lab., NM (United States)

    1996-10-01

    A steel containment vessel was fabricated and proof tested for use by the Los Alamos National Laboratory at their M-9 facility. The HY-100 steel vessel was designed to provide total containment for high explosives tests up to 22 lb (10 kg) of TNT equivalent. The vessel was fabricated from an 11.5-ft diameter cylindrical shell, 1.5 in thick, and 2:1 elliptical ends, 2 in thick. Prior to delivery and acceptance, three types of tests were required for proof testing the vessel: a hydrostatic pressure test, air leak tests, and two full design charge explosion tests. The hydrostatic pressure test provided an initial static check on the capacity of the vessel and functioning of the strain instrumentation. The pneumatic air leak tests were performed before, in between, and after the explosion tests. After three smaller preliminary charge tests, the full design charge weight explosion tests demonstrated that no yielding occurred in the vessel at its rated capacity. The blast pressures generated by the explosions and the dynamic response of the vessel were measured and recorded with 33 strain channels, 4 blast pressure channels, 2 gas pressure channels, and 3 displacement channels. This paper presents an overview of the test program, a short summary of the methodology used to predict the design blast loads, a brief description of the transducer locations and measurement systems, some of the hydrostatic test strain and stress results, examples of the explosion pressure and dynamic strain data, and some comparisons of the measured data with the design loads and stresses on the vessel.

  14. Design concept for vessels and heat exchangers

    International Nuclear Information System (INIS)

    Elfmann, W.; Ferrari, L.D.B.

    1981-01-01

    A design concept for vessels and heat exchangers against internal and external loads resulting from normal operation and accident is shown. A definition and explanation of the operating conditions and stress levels are given. A description of the type of analysis (stress, fatigue, deformation, stability, earthquake and vibration) is presented in detail, also including technical guidelines which are used for the vessels and heat exchangers and their individual structure parts. (Author) [pt

  15. ITER vacuum vessel design and electromagnetic analysis on in-vessel components

    International Nuclear Information System (INIS)

    Ioki, K.; Johnson, G.; Shimizu, K.; Williamson, D.; Iizuka, T.

    1995-01-01

    Major functional requirements for the vacuum vessel are to provide the first safety barrier and to support electromagnetic loads due to plasma disruptions and vertical displacement events, and to withstand plausible accidents without losing confinement. A double wall structure concept has been developed for the vacuum vessel due to its beneficial characteristics from the viewpoints of structural integrity and electrical continuity. An electromagnetic analysis of the blanket modules and the vacuum vessel has been performed to investigate force distributions on in-vessel components. According to the vertical displacement events (VDE) scenario, which assumes a critical q-value of 1.5, the total downward vertical force, induced by coupling between the eddy current and external fields, is about 110 MN. We have performed a stress analysis for the vacuum vessel using the VDE disruption forces acting on the blankets, and a maximum stress intensity of 112 MPa was obtained in the vicinity of the lower support of the vessel. (orig.)

  16. Pressure vessel integrity and weld inspection procedure

    International Nuclear Information System (INIS)

    Solomon, K.A.; Okrent, D.; Kastenberg, W.E.

    1975-01-01

    The primary objective of this paper is to develop a simple methodology which, when coupled with existing observations on pressure vessel behavior, provides an inter-relation between pressure vessel integrity, and the parameters of the in-service inspection program, including inspection sample size, frequency and efficiency. A modified Markov process is employed and a computer code was written to obtain numerical results. The Markov process mathematically describes the following physical events. In a nuclear reactor pressure vessel weld, some defects may exist prior to the zeroth inspection (i.e., prior to vessel operation). During the zeroth inspection and repair processes, some of these defects are removed. During the first cycle of vessel operation, the existing defects may grow and some new defects may be generated. Those defects that are found at the first (and succeeding) inspection interval and warrant repair, are repaired. The above process continues through several operating cycles to the end of vessel life. During any inspection, only a portion of the welds may be inspected, and with less than perfect efficiency

  17. Problems in Pressure Vessel Design and Manufacture

    Energy Technology Data Exchange (ETDEWEB)

    Hellstroem, O [Uddeholms AB, Degerfors (Sweden); Nilson, Ragnar [AB Atomenergi, Nykoeping (Sweden)

    1963-05-15

    The general desire by the power reactor process makers to increase power rating and their efforts to involve more advanced thermal behaviour and fuel handling facilities within the reactor vessels are accompanied by an increase in both pressure vessel dimensions and various difficulties in giving practical solutions of design materials and fabrication problems. In any section of this report it is emphasized that difficulties and problems already met with will meet again in the future vessels but then in modified forms and in many cases more pertinent than before. As for the increase in geometrical size it can be postulated that with use of better materials and adjusted fabrication methods the size problems can be taken proper care of. It seems likely that vessels of sufficient large diameter and height for the largest power output, which is judged as interesting in the next ten year period, can be built without developing totally new site fabrication technique. It is, however, supposed that such a fabrication technique will be feasible though at higher specific costs for the same quality requirements as obtained in shop fabrication. By the postulated use of more efficient vessel material with principally the same good features of easy fabrication in different stages such as preparation, welding, heat treatment etc as ordinary or slightly modified carbon steels the increase in wall thickness might be kept low. There exists, however, a development work to be done for low-alloy steels to prove their justified use in large reactor pressure vessels.

  18. The pressure vessel for the NSF tandem

    International Nuclear Information System (INIS)

    Jones, C.W.

    1979-04-01

    The pressure vessel is a major component of the 30 MV tandem Van de Graaff electrostatic accelerator to be used in nuclear structure research at Daresbury Laboratory. The accelerator will be capable of accelerating the full range of ions in the form of a beam. Acceleration takes place in a vertical evacuated tube (beam tube) by means of a high potential on a terminal at the central position, the terminal and beam tube assembly being supported by an insulated stack structure within the pressure vessel. Under operating conditions the vessel is filled with sulphur hexafluoride gas (SF 6 ) at high pressure which acts as an insulating medium between the centre terminal and the vessel wall. The vessel is situated inside a concrete tower which besides supporting the injector room above the vessel also acts as radiation shielding around the accelerator. The report covers: functional requirements; fundamental considerations with regard to the design and procurement; detail design; materials; manufacture; acceptance test; surface treatment; final leak test. (U.K.)

  19. Crack propagation on spherical pressure vessels

    International Nuclear Information System (INIS)

    Lebey, J.; Roche, R.

    1975-01-01

    The risk presented by a crack on a pressure vessel built with a ductile steel cannot be well evaluated by simple application of the rules of Linear Elastic Fracture Mechanics, which only apply to brittle materials. Tests were carried out on spherical vessels of three different scales built with the same steel. Cracks of different length were machined through the vessel wall. From the results obtained, crack initiation stress (beginning of stable propagation) and instable propagation stress may be plotted against the lengths of these cracks. For small and medium size, subject to ductile fracture, the resulting curves are identical, and may be used for ductile fracture prediction. Brittle rupture was observed on larger vessels and crack propagation occurred at lower stress level. Preceedings curves are not usable for fracture analysis. Ultimate pressure can be computed with a good accuracy by using equivalent energy toughness, Ksub(1cd), characteristic of the metal plates. Satisfactory measurements have been obtained on thin samples. The risks of brittle fracture may then judged by comparing Ksub(1cd) with the calculated K 1 value, in which corrections for vessel shape are taken into account. It is thus possible to establish the bursting pressure of cracked spherical vessels, with the help of two rules, one for brittle fracture, the other for ductile instability. A practical method is proposed on the basis of the work reported here

  20. Problems in Pressure Vessel Design and Manufacture

    International Nuclear Information System (INIS)

    Hellstroem, O.; Nilson, Ragnar

    1963-05-01

    The general desire by the power reactor process makers to increase power rating and their efforts to involve more advanced thermal behaviour and fuel handling facilities within the reactor vessels are accompanied by an increase in both pressure vessel dimensions and various difficulties in giving practical solutions of design materials and fabrication problems. In any section of this report it is emphasized that difficulties and problems already met with will meet again in the future vessels but then in modified forms and in many cases more pertinent than before. As for the increase in geometrical size it can be postulated that with use of better materials and adjusted fabrication methods the size problems can be taken proper care of. It seems likely that vessels of sufficient large diameter and height for the largest power output, which is judged as interesting in the next ten year period, can be built without developing totally new site fabrication technique. It is, however, supposed that such a fabrication technique will be feasible though at higher specific costs for the same quality requirements as obtained in shop fabrication. By the postulated use of more efficient vessel material with principally the same good features of easy fabrication in different stages such as preparation, welding, heat treatment etc as ordinary or slightly modified carbon steels the increase in wall thickness might be kept low. There exists, however, a development work to be done for low-alloy steels to prove their justified use in large reactor pressure vessels

  1. Limiting Factors for External Reactor Vessel Cooling

    International Nuclear Information System (INIS)

    Cheung, F.B.

    2005-01-01

    The method of external reactor vessel cooling (ERVC) that involves flooding of the reactor cavity during a severe accident has been considered a viable means for in-vessel retention (IVR). For high-power reactors, however, there are some limiting factors that might adversely affect the feasibility of using ERVC as a means for IVR. In this paper, the key limiting factors for ERVC have been identified and critically discussed. These factors include the choking limit for steam venting (CLSV) through the bottleneck of the vessel/insulation structure, the critical heat flux (CHF) for downward-facing boiling on the vessel outer surface, and the two-phase flow instabilities in the natural circulation loop within the flooded cavity. To enhance ERVC, it is necessary to eliminate or relax these limiting factors. Accordingly, methods to enhance ERVC and thus improve margins for IVR have been proposed and demonstrated, using the APR1400 as an example. The strategy is based on using two distinctly different methods to enhance ERVC. One involves the use of an enhanced vessel/insulation design to facilitate steam venting through the bottleneck of the annular channel. The other involves the use of an appropriate vessel coating to promote downward-facing boiling. It is found that the use of an enhanced vessel/insulation design with bottleneck enlargement could greatly facilitate the process of steam venting through the bottleneck region as well as streamline the resulting two-phase motions in the annular channel. By selecting a suitable enhanced vessel/insulation design, not only the CLSV but also the CHF limits could be significantly increased. In addition, the problem associated with two-phase flow instabilities and flow-induced mechanical vibration could be minimized. It is also found that the use of vessel coatings made of microporous metallic layers could greatly facilitate downward-facing boiling on the vessel outer surface. With vessel coatings, the local CHF limits at

  2. Prediction of an internal boundary layer on a flat plate after a step change in roughness using a near-wall RANS model

    Science.gov (United States)

    Chu, Minghan; Meng, Fanxiao; Bergstrom, Donald J.

    2017-11-01

    An in-house computational fluid dynamics code was used to simulate turbulent flow over a flat plate with a step change in roughness, exhibiting a smooth-rough-smooth configuration. An internal boundary layer (IBL) is formed at the transition from the smooth to rough (SR) and then the rough to smooth (RS) surfaces. For an IBL the flow far above the surface has experienced a wall shear stress that is different from the local value. Within a Reynolds-Averaged-Navier-Stokes (RANS) formulation, the two-layer k- ɛ model of Durbin et al. (2001) was implemented to analyze the response of the flow to the change in surface condition. The numerical results are compared to experimental data, including some in-house measurements and the seminal work of Antonia and Luxton (1971,72). This problem captures some aspects of roughness in industrial and environmental applications, such as corrosion and the earth's surface heterogeneity, where the roughness is often encountered as discrete distributions. It illustrates the challenge of incorporating roughness models in RANS that are capable of responding to complex surface roughness profiles.

  3. Evolution and variability of Solanum RanGAP2, a cofactor in the incompatible interaction between the resistance protein GPA2 and the Globodera pallida effector Gp-RBP-1.

    Science.gov (United States)

    Carpentier, Jean; Grenier, Eric; Esquibet, Magalie; Hamel, Louis-Philippe; Moffett, Peter; Manzanares-Dauleux, Maria J; Kerlan, Marie-Claire

    2013-04-19

    The Ran GTPase Activating Protein 2 (RanGAP2) was first described as a regulator of mitosis and nucleocytoplasmic trafficking. It was then found to interact with the Coiled-Coil domain of the Rx and GPA2 resistance proteins, which confer resistance to Potato Virus X (PVX) and potato cyst nematode Globodera pallida, respectively. RanGAP2 is thought to mediate recognition of the avirulence protein GP-RBP-1 by GPA2. However, the Gpa2-induced hypersensitive response appears to be relatively weak and Gpa2 is limited in terms of spectrum of efficiency as it is effective against only two nematode populations. While functional and evolutionary analyses of Gp-Rbp-1 and Gpa2 identified key residues in both the resistance and avirulence proteins that are involved in recognition determination, whether variation in RanGAP2 also plays a role in pathogen recognition has not been investigated. We amplified a total of 147 RanGAP2 sequences from 55 accessions belonging to 18 different di-and tetraploid Solanum species from the section Petota. Among the newly identified sequences, 133 haplotypes were obtained and 19.1% of the nucleotide sites were found to be polymorphic. The observed intra-specific nucleotide diversity ranges from 0.1 to 1.3%. Analysis of the selection pressures acting on RanGAP2 suggests that this gene evolved mainly under purifying selection. Nonetheless, we identified polymorphic positions in the protein sequence at the intra-specific level, which could modulate the activity of RanGAP2. Two polymorphic sites and a three amino-acid deletion in RanGAP2 were found to affect the timing and intensity of the Gpa2-induced hypersensitive response to avirulent GP-RBP-1 variants even though they did not confer any gain of recognition of virulent GP-RBP-1 variants. Our results highlight how a resistance gene co-factor can manage in terms of evolution both an established role as a cell housekeeping gene and an implication in plant parasite interactions. StRanGAP2 gene

  4. Vessel discoloration detection in malarial retinopathy

    Science.gov (United States)

    Agurto, C.; Nemeth, S.; Barriga, S.; Soliz, P.; MacCormick, I.; Taylor, T.; Harding, S.; Lewallen, S.; Joshi, V.

    2016-03-01

    Cerebral malaria (CM) is a life-threatening clinical syndrome associated with malarial infection. It affects approximately 200 million people, mostly sub-Saharan African children under five years of age. Malarial retinopathy (MR) is a condition in which lesions such as whitening and vessel discoloration that are highly specific to CM appear in the retina. Other unrelated diseases can present with symptoms similar to CM, therefore the exact nature of the clinical symptoms must be ascertained in order to avoid misdiagnosis, which can lead to inappropriate treatment and, potentially, death. In this paper we outline the first system to detect the presence of discolored vessels associated with MR as a means to improve the CM diagnosis. We modified and improved our previous vessel segmentation algorithm by incorporating the `a' channel of the CIELab color space and noise reduction. We then divided the segmented vasculature into vessel segments and extracted features at the wall and in the centerline of the segment. Finally, we used a regression classifier to sort the segments into discolored and not-discolored vessel classes. By counting the abnormal vessel segments in each image, we were able to divide the analyzed images into two groups: normal and presence of vessel discoloration due to MR. We achieved an accuracy of 85% with sensitivity of 94% and specificity of 67%. In clinical practice, this algorithm would be combined with other MR retinal pathology detection algorithms. Therefore, a high specificity can be achieved. By choosing a different operating point in the ROC curve, our system achieved sensitivity of 67% with specificity of 100%.

  5. Pressurized wet digestion in open vessels (T11)

    International Nuclear Information System (INIS)

    Kettisch, P.; Maichin, P.; Zischka, M.; Knapp, G.

    2002-01-01

    Full text: Pressurized wet digestion in closed vessels, microwave assisted or with conventional conductive heating, is the most important sample preparation technique for digestion or leaching procedures in element analysis. In comparison to open vessel digestion closed vessel digestion methods have many advantages, but there is one disadvantage - complex and expensive vessel designs. A new technique - pressurized wet digestion in open vessels - combine the advantages of closed vessel sample digestion with the application of simple and cheap open vessels made of quartz or PFA. The vessels are placed in a high pressure Asher HPA, which is adapted with a Teflon liner and filled partly with water. The analytical results with 30 ml quartz vessels, 22 ml PFA vessels and 1.5 ml PIA auto sampler cups will be shown. In principle every dimensions of vessels can be used. The vessels are loaded with sample material (max. 1.5 g with quartz vessels, max. 0.5 g with PFA vessels and 50 mg with auto sampler cups) and digestion reagent. Afterwards the vessels are simply covered with PTFE stoppers and not sealed. The vessels are transferred into a special adapted HPA and digested at temperatures up to 270 o C. The digestion time is 90 min. and cooling down to room temperature 30 min. The analytical results of CRM's are within the certified values and no cross contamination and losses of volatile elements could be observed. (author)

  6. 46 CFR 15.405 - Familiarity with vessel characteristics.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Familiarity with vessel characteristics. 15.405 Section... MANNING REQUIREMENTS Manning Requirements; All Vessels § 15.405 Familiarity with vessel characteristics. Each credentialed individual must become familiar with the relevant characteristics of the vessel on...

  7. Reactor vessel supported by flexure member

    International Nuclear Information System (INIS)

    Crawford, J.D.; Pankow, B.

    1977-01-01

    According to the present invention there is provided an improved arrangement for supporting a reactor vessel within a containment structure against static and dynamic vertical loadings capable of being imposed as a result of a serious accident as well as during periods of normal plant operation. The support arrangement of the invention is, at the same time, capable of accommodating radial displacements that normally occur between the reactor vessel and the containment structure due to operational transients. The arrangement comprises a plurality of vertical columns connected between the reactor vessel and a support base within the containment structure. The columns are designed to accommodate relative displacements between the vessel and the containment structure by flexing. This eliminates the need for relative sliding movements and thus enables the columns to be securely fixed to the vessel. This elimination of a provision for relative sliding movements avoids the spaces or gaps between the retention members and the retained elements as occurred in prior art arrangements and, concomitantly, the danger of establishing impact forces on the retention members in the event of an accident is reduced. (author)

  8. Baking results of KSTAR vacuum vessel

    Energy Technology Data Exchange (ETDEWEB)

    Kim, S. T.; Kim, Y. J.; Kim, K. M.; Im, D. S.; Joung, N. Y.; Yang, H. L.; Kim, Y. S.; Kwon, M. [National Fusion Research Institute, Daejeon (Korea, Republic of)

    2009-05-15

    The Korea Superconducting Tokamak Advanced Research (KSTAR) is an advanced superconducting tokamak designed to establish a scientific and technological basis for an attractive fusion reactor. The fusion energy in the tokamak device is released through fusion reactions of light atoms such as deuterium or helium in hot plasma state, of which temperature reaches several hundreds of millions Celsius. The high temperature plasma is created in the vacuum vessel that provides ultra high vacuum status. Accordingly, it is most important for the vacuum condition to keep clean not only inner space but also surface of the vacuum vessel to make high quality plasma. There are two methods planned to clean the wall surface of the KSTAR vacuum vessel. One is surface baking and the other is glow discharge cleaning (GDC). To bake the vacuum vessel, De-Ionized (DI) water is heated to 130 .deg. C and circulated in the passage between double walls of the vacuum vessel (VV) in order to bake the surface. The GDC operation uses hydrogen and inert gas discharges. In this paper, general configuration and brief introduction of the baking result will be reported.

  9. Guidelines for pressure vessel safety assessment

    Science.gov (United States)

    Yukawa, S.

    1990-04-01

    A technical overview and information on metallic pressure containment vessels and tanks is given. The intent is to provide Occupational Safety and Health Administration (OSHA) personnel and other persons with information to assist in the evaluation of the safety of operating pressure vessels and low pressure storage tanks. The scope is limited to general industrial application vessels and tanks constructed of carbon or low alloy steels and used at temperatures between -75 and 315 C (-100 and 600 F). Information on design codes, materials, fabrication processes, inspection and testing applicable to the vessels and tanks are presented. The majority of the vessels and tanks are made to the rules and requirements of ASME Code Section VIII or API Standard 620. The causes of deterioration and damage in operation are described and methods and capabilities of detecting serious damage and cracking are discussed. Guidelines and recommendations formulated by various groups to inspect for the damages being found and to mitigate the causes and effects of the problems are presented.

  10. Cholinergic innervation of human mesenteric lymphatic vessels.

    Science.gov (United States)

    D'Andrea, V; Bianchi, E; Taurone, S; Mignini, F; Cavallotti, C; Artico, M

    2013-11-01

    The cholinergic neurotransmission within the human mesenteric lymphatic vessels has been poorly studied. Therefore, our aim is to analyse the cholinergic nerve fibres of lymphatic vessels using the traditional enzymatic techniques of staining, plus the biochemical modifications of acetylcholinesterase (AChE) activity. Specimens obtained from human mesenteric lymphatic vessels were subjected to the following experimental procedures: 1) drawing, cutting and staining of tissues; 2) staining of total nerve fibres; 3) enzymatic staining of cholinergic nerve fibres; 4) homogenisation of tissues; 5) biochemical amount of proteins; 6) biochemical amount of AChE activity; 6) quantitative analysis of images; 7) statistical analysis of data. The mesenteric lymphatic vessels show many AChE positive nerve fibres around their wall with an almost plexiform distribution. The incubation time was performed at 1 h (partial activity) and 6 h (total activity). Moreover, biochemical dosage of the same enzymatic activity confirms the results obtained with morphological methods. The homogenates of the studied tissues contain strong AChE activity. In our study, the lymphatic vessels appeared to contain few cholinergic nerve fibres. Therefore, it is expected that perivascular nerve stimulation stimulates cholinergic nerves innervating the mesenteric arteries to release the neurotransmitter AChE, which activates muscarinic or nicotinic receptors to modulate adrenergic neurotransmission. These results strongly suggest, that perivascular cholinergic nerves have little or no effect on the adrenergic nerve function in mesenteric arteries. The cholinergic nerves innervating mesenteric arteries do not mediate direct vascular responses.

  11. Baking results of KSTAR vacuum vessel

    International Nuclear Information System (INIS)

    Kim, S. T.; Kim, Y. J.; Kim, K. M.; Im, D. S.; Joung, N. Y.; Yang, H. L.; Kim, Y. S.; Kwon, M.

    2009-01-01

    The Korea Superconducting Tokamak Advanced Research (KSTAR) is an advanced superconducting tokamak designed to establish a scientific and technological basis for an attractive fusion reactor. The fusion energy in the tokamak device is released through fusion reactions of light atoms such as deuterium or helium in hot plasma state, of which temperature reaches several hundreds of millions Celsius. The high temperature plasma is created in the vacuum vessel that provides ultra high vacuum status. Accordingly, it is most important for the vacuum condition to keep clean not only inner space but also surface of the vacuum vessel to make high quality plasma. There are two methods planned to clean the wall surface of the KSTAR vacuum vessel. One is surface baking and the other is glow discharge cleaning (GDC). To bake the vacuum vessel, De-Ionized (DI) water is heated to 130 .deg. C and circulated in the passage between double walls of the vacuum vessel (VV) in order to bake the surface. The GDC operation uses hydrogen and inert gas discharges. In this paper, general configuration and brief introduction of the baking result will be reported

  12. Head spray nozzle in reactor pressure vessel

    International Nuclear Information System (INIS)

    Hatano, Shun-ichi.

    1990-01-01

    In a reactor pressure vessel of a BWR type reactor, a head spray nozzle is used for cooling the head of the pressure vessel and, in view of the thermal stresses, it is desirable that cooling is applied as uniformly as possible. A conventional head spray is constituted by combining full cone type nozzles. Since the sprayed water is flown down upon water spraying and the sprayed water in the vertical direction is overlapped, the flow rate distribution has a high sharpness to form a shape as having a maximum value near the center and it is difficult to obtain a uniform flow rate distribution in the circumferential direction. Then, in the present invention, flat nozzles each having a spray water cross section of laterally long shape, having less sharpness in the circumferential distribution upon spraying water to the inner wall of the pressure vessel and having a wide angle of water spray are combined, to make the flow rate distribution of spray water uniform in the inner wall of the pressure vessel. Accordingly, the pressure vessel can be cooled uniformly and thermal stresses upon cooling can be decreased. (N.H.)

  13. Trends in Tissue Engineering for Blood Vessels

    Directory of Open Access Journals (Sweden)

    Judee Grace Nemeno-Guanzon

    2012-01-01

    Full Text Available Over the years, cardiovascular diseases continue to increase and affect not only human health but also the economic stability worldwide. The advancement in tissue engineering is contributing a lot in dealing with this immediate need of alleviating human health. Blood vessel diseases are considered as major cardiovascular health problems. Although blood vessel transplantation is the most convenient treatment, it has been delimited due to scarcity of donors and the patient’s conditions. However, tissue-engineered blood vessels are promising alternatives as mode of treatment for blood vessel defects. The purpose of this paper is to show the importance of the advancement on biofabrication technology for treatment of soft tissue defects particularly for vascular tissues. This will also provide an overview and update on the current status of tissue reconstruction especially from autologous stem cells, scaffolds, and scaffold-free cellular transplantable constructs. The discussion of this paper will be focused on the historical view of cardiovascular tissue engineering and stem cell biology. The representative studies featured in this paper are limited within the last decade in order to trace the trend and evolution of techniques for blood vessel tissue engineering.

  14. Unsupervised Retinal Vessel Segmentation Using Combined Filters.

    Directory of Open Access Journals (Sweden)

    Wendeson S Oliveira

    Full Text Available Image segmentation of retinal blood vessels is a process that can help to predict and diagnose cardiovascular related diseases, such as hypertension and diabetes, which are known to affect the retinal blood vessels' appearance. This work proposes an unsupervised method for the segmentation of retinal vessels images using a combined matched filter, Frangi's filter and Gabor Wavelet filter to enhance the images. The combination of these three filters in order to improve the segmentation is the main motivation of this work. We investigate two approaches to perform the filter combination: weighted mean and median ranking. Segmentation methods are tested after the vessel enhancement. Enhanced images with median ranking are segmented using a simple threshold criterion. Two segmentation procedures are applied when considering enhanced retinal images using the weighted mean approach. The first method is based on deformable models and the second uses fuzzy C-means for the image segmentation. The procedure is evaluated using two public image databases, Drive and Stare. The experimental results demonstrate that the proposed methods perform well for vessel segmentation in comparison with state-of-the-art methods.

  15. TMI-2 Vessel Investigation Project Metallurgical Program

    International Nuclear Information System (INIS)

    Diercks, D.R.; Neimark, L.A.

    1990-01-01

    The TMI-2 [Three Mile Island unit 2] Vessel Investigation Project Metallurgical Program at Argonne National Laboratory is a part of the international TMI-2 Vessel Investigation Project being conducted jointly by the U.S. Nuclear Regulatory Commission and the Organization for Economic Co-operation and Development (OECD). The overall project consists of three phases, namely (1) recovery of material samples from the lower head of the TMI-2 reactor, (2) examination and analysis of the lower head samples and the preparation and testing of archive material subjected to a similar thermal history, and (3) procurement, examination, and analysis of companion core material located adjacent to or near the lower head material. The specific objectives of the ANL Metallurgical Program, which accounts for a major portion of Phase 2, are to prepare metallographic and mechanical test specimen blanks from the TMI-2 lower head material, prepare similar test specimen blanks from suitable archive material subjected to the appropriate thermal processing, determine the mechanical properties of the lower vessel head and archive materials under the conditions of the core-melt accident, and assess the lower head integrity and margin-to-failure during the accident. The ANL work consists of three tasks: (1) archive materials program, (2) fabrication of metallurgical and mechanical test specimens from the TMI-2 pressure vessel samples, and (3) mechanical property characterization of TMI-2 lower pressure vessel head and archive material

  16. Foundamental characteristics of layered pressure vessel

    International Nuclear Information System (INIS)

    Moriwaki, Yoshikazu; Fugino, Masayuki; Shimizu, Yasuhiro; Nakamura, Takeshi

    1978-01-01

    Pressure vessels become larger and the working pressure become higher with the remarkable development of petroleum, chemical, thermal power generation and atomic energy industries. Multi-layered pressure vessels can be manufactured cheaply without large installations, and large wall thickness can be made, therefore they are suitable for large pressure vessels. The stress and deformation behaviors of such vessels are very complex because of the effect of frictional force working between layers. In this study, the phenomena arising in multiple layers and the difference as compared with single wall were studied fundamentally as one step for analyzing multi-layered pressure vessels as a whole. Finite element technique was employed as the analyzing method, and the behavior of multiple layers was analyzed, regarding it as multiple contact problem. The behavior of multiple layers seems to appear conspicuously in case of bending load, therefore the basic characteristics regarding bending were examined. The evaluation of interfacial stiffness was carried out by experiment. The computer program for analyzing multiple contact problem was developed. In order to examine the validity of the program, comparison with the analytical solution heretofore and the result of calculation by finite element technique was carried out. Moreover, the experimental proof with multi-layered models was made. The frictional force between layers hardly contributes to the stiffness. (Kako, I.)

  17. NMR blood vessel imaging method and apparatus

    International Nuclear Information System (INIS)

    Riederer, S.J.

    1988-01-01

    A high speed method of forming computed images of blood vessels based on measurements of characteristics of a body is described comprising the steps of: subjecting a predetermined body area containing blood vessels of interest to, successively, applications of a short repetition time (TR) NMR pulse sequence during the period of high blood velocity and then to corresponding applications during the period of low blood velocity for successive heart beat cycles; weighting the collected imaging data from each application of the NMR pulse sequence according to whether the data was acquired during the period of high blood velocity or a period of low blood velocity of the corresponding heart beat cycle; accumulating weighted imaging data from a plurality of NMR pulse sequences corresponding to high blood velocity periods and from a plurality of NMR pulse sequences corresponding to low blood velocity periods; subtracting the weighted imaging data corresponding to each specific phase encoding acquired during the high blood velocity periods from the weighted imaging data for the same phase encoding corresponding to low blood velocity periods in order to compute blood vessel imaging data; and forming an image of the blood vessels of interest from the blood vessel imaging data

  18. Integration of ITER in-vessel diagnostic components in the vacuum vessel

    International Nuclear Information System (INIS)

    Encheva, A.; Bertalot, L.; Macklin, B.; Vayakis, G.; Walker, C.

    2009-01-01

    The integration of ITER in-vessel diagnostic components is an important engineering activity. The positioning of the diagnostic components must correlate not only with their functional specifications but also with the design of the major parts of ITER torus, in particular the vacuum vessel, blanket modules, blanket manifolds, divertor, and port plugs, some of which are not yet finally designed. Moreover, the recently introduced Edge Localised Mode (ELM)/Vertical Stability (VS) coils mounted on the vacuum vessel inner wall call for not only more than a simple review of the engineering design settled down for several years now, but also for a change in the in-vessel distribution of the diagnostic components and their full impact has yet to be determined. Meanwhile, the procurement arrangement (a document defining roles and responsibilities of ITER Organization and Domestic Agency(s) (DAs) for each in-kind procurement including technical scope of work, quality assurance requirements, schedule, administrative matters) for the vacuum vessel must be finalized. These make the interface process even more challenging in terms of meeting the vacuum vessel (VV) procurement arrangement's deadline. The process of planning the installation of all the ITER diagnostics and integrating their installation into the ITER Integrated Project Schedule (IPS) is now underway. This paper covers the progress made recently on updating and issuing the interfaces of the in-vessel diagnostic components with the vacuum vessel, outlines the requirements for their attachment and summarises the installation sequence.

  19. Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity.

    Science.gov (United States)

    Wang, Yixin; Jin, Yi; Mäe, Maarja Andaloussi; Zhang, Yang; Ortsäter, Henrik; Betsholtz, Christer; Mäkinen, Taija; Jakobsson, Lars

    2017-10-01

    Tissue fluid drains through blind-ended lymphatic capillaries, via smooth muscle cell (SMC)-covered collecting vessels into venous circulation. Both defective SMC recruitment to collecting vessels and ectopic recruitment to lymphatic capillaries are thought to contribute to vessel failure, leading to lymphedema. However, mechanisms controlling lymphatic SMC recruitment and its role in vessel maturation are unknown. Here, we demonstrate that platelet-derived growth factor B (PDGFB) regulates lymphatic SMC recruitment in multiple vascular beds. PDGFB is selectively expressed by lymphatic endothelial cells (LECs) of collecting vessels. LEC-specific deletion of Pdgfb prevented SMC recruitment causing dilation and failure of pulsatile contraction of collecting vessels. However, vessel remodelling and identity were unaffected. Unexpectedly, Pdgfb overexpression in LECs did not induce SMC recruitment to capillaries. This was explained by the demonstrated requirement of PDGFB extracellular matrix (ECM) retention for lymphatic SMC recruitment, and the low presence of PDGFB-binding ECM components around lymphatic capillaries. These results demonstrate the requirement of LEC-autonomous PDGFB expression and retention for SMC recruitment to lymphatic vessels, and suggest an ECM-controlled checkpoint that prevents SMC investment of capillaries, which is a common feature in lymphedematous skin. © 2017. Published by The Company of Biologists Ltd.

  20. Earthquake-proof supporting structure in reactor vessel

    International Nuclear Information System (INIS)

    Sakurai, Akio; Sekine, Katsuhisa; Madokoro, Manabu; Katoono, Shin-ichi; Konno, Mutsuo; Suzuki, Takuro.

    1990-01-01

    Conventional earthquake-proof structure comprises a vessel vibration stopper integrated to a reactor vessel, powder for restricting the horizontal displacements, a safety vessel surrounds the outer periphery of the reactor vessel and a safety vessel vibration stopper integrated therewith, which are fixed to buildings. However, there was a problem that a great amount of stresses are generated in the base of the reactor vessel vibration stopper due to reaction of the powders which restrict thermal expansion. In order to remarkably reduce the reaction of the powers, powders are charged into a spaces formed between each of the reactor vessel vibration stopper, the safety vessel vibration stopper and the flexible member disposed between them. According to this constitution, the reactor vessel vibration stopper does not undergo a great reaction of the powers upon thermal expansion of the reactor vessel to moderate the generated stresses, maintain the strength and provide earthquake-proof supporting function. (N.H.)

  1. Test of 6-in.-thick pressure vessels. Series 3: intermediate test vessel V-7

    International Nuclear Information System (INIS)

    Merkle, J.G.; Robinson, G.C.; Holz, P.P.; Smith, J.E.; Bryan, R.H.

    1976-08-01

    The test of intermediate test vessel V-7 was a crack-initiation fracture test of a 152-mm-thick (6-in.), 990-mm-OD (39-in.) vessel of ASTM A533, grade B, class 1 steel plate with a sharp outside surface flaw 457 mm (18 in.) long and about 135 mm (5.3 in.) deep. The vessel was heated to 91 0 C (196 0 F) and pressurized hydraulically until leakage through the flaw terminated the test at a peak pressure of 147 MPa (21,350 psi). Fracture toughness data obtained by testing precracked Charpy-V and compact-tension specimens machined from a prolongation of the cylindrical test shell were used in pretest analyses of the flawed vessel. The vessel, as expected, did not burst. Upon depressurization, the ruptured ligament closed so as to maintain static pressure without leakage at about 129 MPa

  2. Seals for sealing a pressure vessel such as a nuclear reactor vessel or the like

    International Nuclear Information System (INIS)

    Bruns, H.J.; Huelsermann, K.H.

    1975-01-01

    A description is given of seals for sealing a pressure vessel such as a nuclear reactor vessel, steam boiler vessel, or any other vessel which is desirably sealed against pressure of the type including a housing and a housing closure that present opposed vertical sealing surfaces which define the sides of a channel. The seals of the present invention comprise at least one sealing member disposed in the channel, having at least one stop face, a base portion and two shank portions extending from the base portion to form a groove-like recess. The shank portions are provided with sealing surfaces arranged to mate with the opposed vertical pressure vessel sealing surfaces. A shank-spreading wedge element also disposed in the channel has at least one stop face and is engaged in the groove-like recess with the sealing member and wedge element stop face adjacent to each other

  3. From DNS to RANS: A Multi-model workflow to understand the Influence of Hurricanes on Generating Turbidity Currents in the Gulf of Mexico

    Science.gov (United States)

    Syvitski, J. P.; Arango, H.; Harris, C. K.; Meiburg, E. H.; Jenkins, C. J.; Auad, G.; Hutton, E.; Kniskern, T. A.; Radhakrishnan, S.

    2016-12-01

    A loosely coupled numerical workflow is developed to address land-sea pathways for sediment routing from terrestrial and coastal sources, across the continental shelf and ultimately down the continental slope canyon system of the northern Gulf of Mexico (GOM). Model simulations represent a range of environmental conditions that might lead to the generation of turbidity-currents. The workflow comprises: 1) A simulator for the water and sediment discharged from rivers into the GOM with WMBsedv2 with calibration using USGS and USACE gauged river data; 2) Domain grids and bathymetry (ETOPO2) for the ocean models and realistic seabed sediment texture grids (dbSEABED) for the sediment transport models; 3) A spectral wave action simulator (10 km resolution) (WaveWatch III) driven by GFDL - GFS winds; 4) A simulator for ocean dynamics (ROMS) forced with ECMWF ERA winds; 5) A simulator for seafloor resuspension and transport (CSTMS); 6) Simulators (HurriSlip) of seafloor failure and flow ignition locations for boundary input to a turbidity current model; and 7) A RANS turbidity current model (TURBINS) to route sediment flows down GOM canyons, providing estimates of bottom shear stresses. TURBINS was developed first as a DNS model and then converted to an LES model wherein a dynamic turbulence closure scheme was employed. Like most DNS to LES model comparisons (these being done by the UCSB team), turbulence scaling allowed for higher Re applications but were found still not capable of simulating field scale (GOM continental canyons) environments. The LES model was next converted to a non-hydrostatic RANS model capable of field scale applications but only with a daisy-chain approach to multiple model runs along the simulated canyon floor. These model adaptations allowed the workflow to be tested for the year 1-Oct-2007 to 30-Sep-2008 that included two domain Hurricanes (Ike and Gustav). The RANS-TURBINS employed further boundary simplifications on both sediment erosion and

  4. Life extension of the BR2 aluminium vessel

    International Nuclear Information System (INIS)

    Koonen, E.; Fabry, A.; Chaouadi, R.; Verwerft, M.; Raedt, C. de; Winckel, S. van; Wacquier, W.; Dadoumont, J.; Verwimp, A.

    2000-01-01

    The BR2 reactor has recently undergone a major refurbishment comprising the replacement of all vessel internals. The vessel itself however was not replaced. An important requalification programme has been executed to prove that the vessel would remain fit during the contemplated life extension period of BR2. Representative material samples could be obtained from the shroud surrounding the vessel. A comprehensive in-service inspection was carried out and a vessel surveillance programme has been established. (author)

  5. Thermal Behavior of the Reactor Vessel Penetration Under External Vessel Cooling During a Severe Accident

    International Nuclear Information System (INIS)

    Kang, Kyoung-Ho; Park, Rae-Joon; Kim, Jong-Tae; Min, Byung-Tae; Lee, Ki-Young; Kim, Sang-Baik

    2004-01-01

    Experimental and analytical studies on the thermal behavior of reactor vessel penetration have been performed under external vessel cooling during a severe accident in the Korean next-generation reactor APR1400. Two types of tests, SUS-EXT and SUS-DRY with and without external vessel cooling, respectively, have been performed using sustained heating by an induction heater. Three tests have been carried out varying the cooling conditions at the vessel outer surface in the SUS-EXT tests. The experimental results have been thermally estimated using the LILAC computer code. The experimental results indicate that the inner surface of the vessel was ablated by the 45-mm thickness in the SUS-DRY test. Despite the total ablation of the welding material, the penetration was not ejected outside the vessel, which could be attributed to the thermal expansion of the penetration. Unlike the SUS-DRY test, the thickness of the ablation was ∼15 to 20 mm at most, so the welding was preserved in the SUS-EXT tests. It is concluded from the experimental results that the external vessel cooling highly affected the ablation configuration and the thermal behaviors of the vessel and the penetration. An increase in coolant mass flow rate from 0.047 to 0.152 kg/s had effects on the thermal behavior of the lower head vessel and penetration in the SUS-EXT tests. The LILAC analytical results on temperature distribution and ablation depth in the lower head vessel and penetration were very similar to the experimental results

  6. Procurement of replacement pressure vessels for MURR

    International Nuclear Information System (INIS)

    Meyer, W.A. Jr.; Edwards, C.B. Jr.; McKibben, J.C.; Schoone, A.R.

    1989-01-01

    The University of Missouri Research Reactor Facility (MURR) located in Columbia, Missouri, is the highest powered, highest steady-state flux university research reactor in the United States. The reactor is a 10-MW pressurized loop, in-pool-type, light-water-moderated, beryllium-reflected, flux trap reactor. MURR has a compact core (0.033 m 3 ) composed of eight fuel elements of the materials test reactor type arranged as an annular right circular cylinder between the inner and outer aluminum pressure vessels. Conservative engineering judgment resulted in the decision in 1988 to purchase new inner and outer pressure vessels. This paper details the difficulties encountered in procuring replacements for aluminum pressure vessels built to standards that are no longer applicable in attempting to meet nuclear standards that are not applicable to nonferrous material

  7. Ex-vessel nuclear fuel transfer system

    International Nuclear Information System (INIS)

    Wade, E.E.

    1978-01-01

    A system for transferring fuel assemblies between a fuel transfer area and a fuel storage area while the fuel assemblies remain completely submerged in a continuous body of coolant is described. A fuel transfer area filled with reactor coolant communicating with the reactor vessel below the reactor coolant level provides a transfer area for fuel assemblies in transit to and from the reactor vessel. A positioning mechanism comprising at least one rotatable plug disposed on a fuel transfer tank located outside the reactor vessel cooperates with either the fuel transfer area or the fuel storage area to position a fuel assembly in transit. When in position, a transporting mechanism cooperating with the positioning mechanism lifts or lowers a chosen fuel assembly. The transporting mechanism together with the positioning mechanism are capable of transferring a fuel assembly between the fuel transfer area and the fuel storage area

  8. Nickel hydrogen common pressure vessel battery development

    Science.gov (United States)

    Jones, Kenneth R.; Zagrodnik, Jeffrey P.

    1992-01-01

    Our present design for a common pressure vessel (CPV) battery, a nickel hydrogen battery system to combine all of the cells into a common pressure vessel, uses an open disk which allows the cell to be set into a shallow cavity; subsequent cells are stacked on each other with the total number based on the battery voltage required. This approach not only eliminates the assembly error threat, but also more readily assures equal contact pressure to the heat fin between each cell, which further assures balanced heat transfer. These heat fin dishes with their appropriate cell stacks are held together with tie bars which in turn are connected to the pressure vessel weld rings at each end of the tube.

  9. TMI-2 Vessel Investigation Project integration report

    International Nuclear Information System (INIS)

    Wolf, J.R.; Rempe, J.L.; Stickler, L.A.; Korth, G.E.; Diercks, D.R.; Neimark, L.A.; Akers, D.W.; Schuetz, B.K.; Shearer, T.L.; Chavez, S.A.; Thinnes, G.L.; Witt, R.J.; Corradini, M.L.; Kos, J.A.

    1994-03-01

    The Three Mile Island Unit 2 (TMI-2) Vessel Investigation Project (VIP) was an international effort that was sponsored by the Nuclear Energy Agency of the Organization for Economic Cooperation and Development. The primary objectives of the VIP were to extract and examine samples from the lower head and to evaluate the potential modes of failure and the margin of structural integrity that remained in the TMI-2 reactor vessel during the accident. This report presents a summary of the major findings and conclusions that were developed from research during the VIP. Results from the various elements of the project are integrated to form a cohesive understanding of the vessel's condition after the accident

  10. EDF studies on PWR vessel internal loading

    International Nuclear Information System (INIS)

    Bellet, S.; Vallat, S.

    1998-01-01

    EDF has undertaken some mechanics and thermal-hydraulics studies with the objective of mastering plant phenomena today and in order to numerically predict the behaviour of vessel internals on units planned for the future. From some justifications already underway after in operation incidents (wear and drop time of RCCA rods, fuel deflection, adapter cracks, baffle bolt cracks) we intend to control reactor vessel flows and mechanical behaviour of internal structures. During normal operation, thermal-hydraulic is the main load of vessel internals. The current approach consists of acquiring the capacity to link different calculations, taking care that codes are qualified for physical phenomena and complex 3D geometries. For baffle assembly, a more simple model of this structure has been used to treat the physical phenomena linked to the LOCA transient. Results are encouraging mainly due to code capacity progression (resolution and models), which allows more and more complex physical phenomena to be treated, like turbulence flow and LOCA. (author)

  11. Evaluation of buckling on containment metallic vessels

    International Nuclear Information System (INIS)

    Silveira, Renato Campos da; Mattar Neto, Miguel

    2000-01-01

    The buckling analysis represents one of the most important aspects of the structural projects of nuclear power plants containment metallic vessels and in this work the Case N-284-1 ASME Code is used for evaluation of those structures submitted to this failure mode. From the stress analysis, performed by using finite element method on discrete structures with shell elements, the procedure of the Code Case are applied to the evaluation of the containment metallic vessel of the Angra 2 nuclear power plant submitted to the own weight, seismic loads and uplift in case of accident. A study of pressure vessel reinforced by rings submit ed to the external pressure. Conclusions and commentaries are established based on the obtained results

  12. [Large vessels vasculopathy in systemic sclerosis].

    Science.gov (United States)

    Tejera Segura, Beatriz; Ferraz-Amaro, Iván

    2015-12-07

    Vasculopathy in systemic sclerosis is a severe, in many cases irreversible, manifestation that can lead to amputation. While the classical clinical manifestations of the disease have to do with the involvement of microcirculation, proximal vessels of upper and lower limbs can also be affected. This involvement of large vessels may be related to systemic sclerosis, vasculitis or atherosclerotic, and the differential diagnosis is not easy. To conduct a proper and early diagnosis, it is essential to start prompt appropriate treatment. In this review, we examine the involvement of large vessels in scleroderma, an understudied manifestation with important prognostic and therapeutic implications. Copyright © 2015 Elsevier España, S.L.U. All rights reserved.

  13. A framework expert system for pressure vessels

    International Nuclear Information System (INIS)

    Wang, Y.C.; Qin, S.J.

    1989-01-01

    Expert systems, known as a powerful tool to those numerical problems accompanied with logical argumentation, are facing the era of extended application into the engineering fields beyond the classical scopes of diagnosis and consultation. With regard to pressure vessels design it seems that the most important task is to establish a general purpose frame based on a microcomputer skeleton system to meet the various requirements of different vessels. The authors have made an attempt to perform such a skeleton designated file, ESTOOL, in order to achieve the objectives of executing numerical calculation combined with logical reasoning, and attaining higher efficiency of rules searching process. It has been successfully patched to the design software package for jacketed vessel with stirring shaft. This paper presents the guiding concepts and basic structure of ESTOOL via knowledge acquisition subsystem and inference engine

  14. Expanding plasma jet in a vacuum vessel

    International Nuclear Information System (INIS)

    Chutov, Yu.I.; Kravchenko, A.Yu.; Yakovetskij, V.S.

    1998-01-01

    The paper deals with numerical calculations of parameters of a supersonic quasi-neutral argon plasma jet expanding into a cylindrical vacuum vessel and interacting with its inner surface. A modified method of large particles was used, the complex set of hydrodynamic equations being broken into simpler components, each of which describes a separate physical process. Spatial distributions of the main parameters of the argon plasma jet were simulated at various times after the jet entering the vacuum vessel, the parameters being the jet velocity field, the full plasma pressure, the electron temperature, the temperature of heavy particles, and the degree of ionization. The results show a significant effect of plasma jet interaction on the plasma parameters. The jet interaction with the vessel walls may result e.g. in excitation of shock waves and rotational plasma motions. (J.U.)

  15. Crashworthy sealed pressure vessel for plutonium transport

    International Nuclear Information System (INIS)

    Andersen, J.A.

    1980-01-01

    A rugged transportation package for the air shipment of radioisotopic materials was recently developed. This package includes a tough, sealed, stainless steel inner containment vessel of 1460 cc capacity. This vessel, intended for a mass load of up to 2 Kg PuO 2 in various isotopic forms (not to exceed 25 watts thermal activity), has a positive closure design consisting of a recessed, shouldered lid fastened to the vessel body by twelve stainless-steel bolts; sealing is accomplished by a ductile copper gasket in conjunction with knife-edge sealing beads on both the body and lid. Follow-on applications of this seal in newer, smaller packages for international air shipments of plutonium safeguards samples, and in newer, more optimized packages for greater payload and improved efficiency and utility, are briefly presented

  16. Containment vessel construction for nuclear power reactors

    International Nuclear Information System (INIS)

    Sulzer, H.D.; Coletti, J.L.

    1975-01-01

    A nuclear containment vessel houses an inner reactor housing structure whose outer wall is closely spaced from the inner wall of the containment vessel. The inner reactor housing structure is divided by an intermediate floor providing an upper chamber for housing the reactor and associated steam generators and a lower chamber directly therebeneath containing a pressure suppression pool. Communication between the upper chamber and the pressure suppression pool is established by conduits extending through the intermediate floor which terminate beneath the level of the pressure suppression pool and by inlet openings in the reactor housing wall beneath the level of the pressure suppression pool which communicate with the annulus formed between the outer wall of the reactor housing structure and the inner wall of the containment vessel. (Official Gazette)

  17. Proactive life extension of pressure vessels

    Science.gov (United States)

    Mager, Lloyd

    1998-03-01

    For a company to maintain its competitive edge in today's global market every opportunity to gain an advantage must be exploited. Many companies are strategically focusing on improved utilization of existing equipment as well as regulatory compliance. Abbott Laboratories is no exception. Pharmaceutical companies such as Abbott Laboratories realize that reliability and availability of their production equipment is critical to be successful and competitive. Abbott Laboratories, like many of our competitors, is working to improve safety, minimize downtime and maximize the productivity and efficiency of key production equipment such as the pressure vessels utilized in our processes. The correct strategy in obtaining these objectives is to perform meaningful inspection with prioritization based on hazard analysis and risk. The inspection data gathered in Abbott Laboratories pressure vessel program allows informed decisions leading to improved process control. The results of the program are reduced risks to the corporation and employees when operating pressure retaining equipment. Accurate and meaningful inspection methods become the cornerstone of a program allowing proper preventative maintenance actions to occur. Successful preventative/predictive maintenance programs must utilize meaningful nondestructive evaluation techniques and inspection methods. Nondestructive examination methods require accurate useful tools that allow rapid inspection for the entire pressure vessel. Results from the examination must allow the owner to prove compliance of all applicable regulatory laws and codes. At Abbott Laboratories the use of advanced NDE techniques, primarily B-scan ultrasonics, has provided us with the proper tools allowing us to obtain our objectives. Abbott Laboratories uses B-scan ultrasonics utilizing a pulse echo pitch catch technique to provide essential data on our pressure vessels. Equipment downtime is reduced because the nondestructive examination usually takes

  18. Fast-neutron nuclear reactor vessel

    International Nuclear Information System (INIS)

    Presciuttini, L.

    1984-01-01

    The reactor vessel comprises a cylindrical shell, of which axis is vertical, coupled at its lower part with a dished bottom. The reactor core rests on a support plate bearing on the bottom of the vessel. The above dished bottom comprises a spherical sector having the same radius and the same axis as the cylindrical shell and joining the lower part of the shell, and a spherical head of which radius is a little more important than the spherical sector one. A cylindrical support for the reactor core is attached to the vessel at the joint between the two dished sections. The invention applies more particularly to integrated type reactors cooled by liquid sodium [fr

  19. Examination of VVER-1000 Reactor Pressure Vessel

    International Nuclear Information System (INIS)

    Matokovic, A.; Picek, E.; Markulin, K.

    2008-01-01

    The increasing demand of a higher level of safety in the operation of the nuclear power plants requires the utilisation of more precise automated equipment to perform in-service inspections. That has been achieved by technological advances in computer technology, in robotics, in examination probe technology with the development of the advanced inspection technique and has also been due to the considerable and varied experience gained in the performance of such inspections. In-service inspection of reactor pressure vessel, especially Russian-designed WWER-1000 presents one of the most important and extensive examination of nuclear power plants primary circuit components. Such examination demand high standards of inspection technology, quality and continual innovation in the field of non-destructive testing advanced technology. A remote underwater contact ultrasonic technique is employed for the examination of the base metal of vessel and reactor welds, whence eddy current method is applied for clad surface examinations. Visual testing is used for examination of the vessel interior. The movement of inspection probes and data positioning are assured by using new reactor pressure vessel tool concept that is fully integrated with inspection systems. The successful performance of reactor pressure vessel is attributed thorough pre-outage planning, training and successful performance demonstration qualification of chosen non-destructive techniques on the specimens with artificial and/or real defects. Furthermore, use of advanced approach of inspection through implementation the state-of-the-art examination equipment significantly reduced the inspection time, radiation exposure to examination personnel, shortening nuclear power plant outage and cutting the total inspection costs. This paper presents advanced approach in the reactor pressure vessel in-service inspections and it is especially developed for WWER-1000 nuclear power plants.(author)

  20. Tubular inverse opal scaffolds for biomimetic vessels

    Science.gov (United States)

    Zhao, Ze; Wang, Jie; Lu, Jie; Yu, Yunru; Fu, Fanfan; Wang, Huan; Liu, Yuxiao; Zhao, Yuanjin; Gu, Zhongze

    2016-07-01

    There is a clinical need for tissue-engineered blood vessels that can be used to replace or bypass damaged arteries. The success of such grafts depends strongly on their ability to mimic native arteries; however, currently available artificial vessels are restricted by their complex processing, controversial integrity, or uncontrollable cell location and orientation. Here, we present new tubular scaffolds with specific surface microstructures for structural vessel mimicry. The tubular scaffolds are fabricated by rotationally expanding three-dimensional tubular inverse opals that are replicated from colloidal crystal templates in capillaries. Because of the ordered porous structure of the inverse opals, the expanded tubular scaffolds are imparted with circumferentially oriented elliptical pattern microstructures on their surfaces. It is demonstrated that these tailored tubular scaffolds can effectively make endothelial cells to form an integrated hollow tubular structure on their inner surface and induce smooth muscle cells to form a circumferential orientation on their outer surface. These features of our tubular scaffolds make them highly promising for the construction of biomimetic blood vessels.There is a clinical need for tissue-engineered blood vessels that can be used to replace or bypass damaged arteries. The success of such grafts depends strongly on their ability to mimic native arteries; however, currently available artificial vessels are restricted by their complex processing, controversial integrity, or uncontrollable cell location and orientation. Here, we present new tubular scaffolds with specific surface microstructures for structural vessel mimicry. The tubular scaffolds are fabricated by rotationally expanding three-dimensional tubular inverse opals that are replicated from colloidal crystal templates in capillaries. Because of the ordered porous structure of the inverse opals, the expanded tubular scaffolds are imparted with circumferentially

  1. Internal Friction of Pressure Vessel Steel Embrittlement

    International Nuclear Information System (INIS)

    Van Ouytsel, K.

    2001-01-01

    The contribution consists of an abstract of a PhD thesis. The thesis contains a literature study, a description of the construction details of a new inverted torsion pendulum. This device was designed to investigate pressure-vessel steels at high amplitudes (10 -4 to 10 -2 ) and over a wide temperature range (90-700K) at approximately 1 Hz in the irradiated condition. Results of measurements on a variety of reactor pressure vessel steels by means of the torsion penduli are reported and interpreted

  2. Integrity of Magnox reactor steel pressure vessels

    International Nuclear Information System (INIS)

    Flewitt, P.E.J.; Williams, G.H.; Wright, M.B.

    1992-01-01

    The background to the safety assessment of the steel reactor pressure vessels for Magnox power stations is reviewed. The evolved philosophy adopted for the 1991 safety cases prepared for the continued operation of four Magnox power stations operated by Nuclear Electric plc is described, together with different aspects of the multi-legged integrity argument. The main revisions to the materials mechanical property data are addressed together with the assessment methodology adopted and their implications for the overall integrity argument formulated for the continued safe operation of these reactor pressure vessels. (author)

  3. Testing of a steel containment vessel model

    International Nuclear Information System (INIS)

    Luk, V.K.; Hessheimer, M.F.; Matsumoto, T.; Komine, K.; Costello, J.F.

    1997-01-01

    A mixed-scale containment vessel model, with 1:10 in containment geometry and 1:4 in shell thickness, was fabricated to represent an improved, boiling water reactor (BWR) Mark II containment vessel. A contact structure, installed over the model and separated at a nominally uniform distance from it, provided a simplified representation of a reactor shield building in the actual plant. This paper describes the pretest preparations and the conduct of the high pressure test of the model performed on December 11-12, 1996. 4 refs., 2 figs

  4. Reactor Structural Materials: Reactor Pressure Vessel Steels

    International Nuclear Information System (INIS)

    Chaouadi, R.

    2000-01-01

    The objectives of SCK-CEN's R and D programme on Rector Pressure Vessel (RPV) Steels are:(1) to complete the fracture toughness data bank of various reactor pressure vessel steels by using precracked Charpy specimens that were tested statically as well as dynamically; (2) to implement the enhanced surveillance approach in a user-friendly software; (3) to improve the existing reconstitution technology by reducing the input energy (short cycle welding) and modifying the stud geometry. Progress and achievements in 1999 are reported

  5. Fast Generation of Container Vessel Stowage Plans

    DEFF Research Database (Denmark)

    Pacino, Dario

    that the vessel is stable and seaworthy, and at the same time arrange the cargo such that the time at port is minimized. Moreover, stowage coordinators only have a limited amount of time to produce the plan. This thesis addresses the question of whether it is possible to automatically generate stowage plans...... test instances provided by a major liner shipping company. Improvements to the modeling of vessel stability and an analysis of its accuracy together with an analysis of the computational complexity of the container stowage problem are also included in the thesis, resulting in an overall in...

  6. Gas-liquid contacting in mixing vessels

    International Nuclear Information System (INIS)

    Mann, R.

    1983-01-01

    This report by Dr. R. Mann of UMIST presents a critical survey of literature on the contacting of gases with liquids in stirred vessels. Research undertaken in the last fifteen years in analysed, and promising areas for future research are identified. The report deals with physical contacting, mass transfer between the gas and liquid phases and the utilisation of the stirred vessel as a gas-liquid reactor. Three sections are given on gas-liquid contacting: physical aspects; interphase mass transfer; and chemical reactions. It also discusses recent new approaches and includes a summary of conclusions, nomenclature and references

  7. Cylindrical pressure vessel constructed of several layers

    International Nuclear Information System (INIS)

    Yamauchi, Takeshi.

    1976-01-01

    For a cylindrical pressure vessel constructed of several layers whose jacket has at least one circumferential weld joining the individual layers, it is proposed to provide this at least at the first bending line turning point (counting from the weld between the jacket and vessel floor), which the sinusoidally shaped jacket has. The section of the jacket extending in between should be made as a full wall section. The proposal is based on calculations of the bending stiffness of cylindrical jackets, which could not yet be confirmed for jackets having several layers. (UWI) [de

  8. In-vessel maintenance remote manipulator system

    International Nuclear Information System (INIS)

    Jimenez, E.

    1978-01-01

    The radiation environment within the Tokamak Fusion Test Reactor (TFTR) vacuum vessel necessitates the development of a Remote Manipulator System (RMS) to perform required periodic inspection and maintenance tasks. The RMS must be able to perform dexterous operations and handle loads that exceed human capabilities. The limited size of the access ports on the TFTR vacuum vessel and the performance profile, defined by the various handling requirements, present unique design constraints. The design approach and formulation of a RMS configuration which satisfies TFTR requirements is presented herein

  9. Interactions of an Arabidopsis RanBPM homologue with LisH-CTLH domain proteins revealed high conservation of CTLH complexes in eukaryotes

    Czech Academy of Sciences Publication Activity Database

    Tomaštíková, Eva; Cenklová, Věra; Kohoutová, Lucie; Petrovská, Beáta; Váchová, Lenka; Halada, Petr; Kočárová, Gabriela; Binarová, Pavla

    2012-01-01

    Roč. 12, č. 83 (2012) ISSN 1471-2229 R&D Projects: GA ČR(CZ) GA204/07/1169; GA ČR GP204/09/P155; GA ČR GAP501/12/2333; GA MŠk(CZ) LC06034; GA MŠk LC545; GA AV ČR IAA500200719 Grant - others:GA MŠk(CZ) ED0007/01/01 Program:ED Institutional research plan: CEZ:AV0Z50380511; CEZ:AV0Z50200510 Keywords : Arabidopsis homologue of RanBPM * CTLH-complex * LisH-CTLH domain proteins Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 4.354, year: 2012

  10. Experimental and numerical study on density stratification erosion phenomena with a vertical buoyant jet in a small vessel

    Energy Technology Data Exchange (ETDEWEB)

    Abe, Satoshi, E-mail: abe.satoshi@jaea.go.jp; Ishigaki, Masahiro; Sibamoto, Yasuteru; Yonomoto, Taisuke

    2016-07-15

    Highlights: • This paper shows results of a small scale experiment and CFD analyses on a density stratification erosion with a vertical buoyant jet. • The particle image velocimetry (PIV) and quadrupole mass spectrometer (QMS) with a multiport rotating valve were applied. • Two typical well-used RANS models were applied. • The simulated stratification erosion was in agreement with the experimental result, which suggested that the turbulence mixing occurred only in the jet impinging region. - Abstract: The Japan Atomic Energy Agency (JAEA) has started the ROSA-SA project to investigate thermal hydraulic phenomena in a reactor containment vessel during a severe accident. The hydrogen distribution in the vessel is one of significant safety issues in discussing a potential of hydrogen combustion in the containment. Density stratification and its break-up are important phenomena affecting the hydrogen distribution. This paper focuses on a density stratification erosion and break-up mechanism with a vertical buoyant jet promoting the turbulent helium transport. Small scale experiment and computational fluid dynamics (CFD) analyses were carried out for investigating this phenomena. In the experiment, a rectangular vessel made with acrylic plates with a width of 1.5 m, a length of 1.5 m and a height of 1.8 m was used for visualizing flow field with particle image velocimetry (PIV) system. The quadrupole mass spectrometer (QMS) system with a multiport rotating valve was applied for measuring gaseous concentration at 20 elevation points. In CFD analysis with OpenFOAM, two typical well-used turbulence models were used: low-Reynolds number type k–ε model and SST k–ω model, with a turbulence model modification to consider the buoyant effect in the stratification. As a result, the stratification erosion in the CFD analyses with the modified turbulence model agreed well with the experimental data, indicating importance of the turbulence damping by the buoyant effect.

  11. Experimental and numerical study on density stratification erosion phenomena with a vertical buoyant jet in a small vessel

    International Nuclear Information System (INIS)

    Abe, Satoshi; Ishigaki, Masahiro; Sibamoto, Yasuteru; Yonomoto, Taisuke

    2016-01-01

    Highlights: • This paper shows results of a small scale experiment and CFD analyses on a density stratification erosion with a vertical buoyant jet. • The particle image velocimetry (PIV) and quadrupole mass spectrometer (QMS) with a multiport rotating valve were applied. • Two typical well-used RANS models were applied. • The simulated stratification erosion was in agreement with the experimental result, which suggested that the turbulence mixing occurred only in the jet impinging region. - Abstract: The Japan Atomic Energy Agency (JAEA) has started the ROSA-SA project to investigate thermal hydraulic phenomena in a reactor containment vessel during a severe accident. The hydrogen distribution in the vessel is one of significant safety issues in discussing a potential of hydrogen combustion in the containment. Density stratification and its break-up are important phenomena affecting the hydrogen distribution. This paper focuses on a density stratification erosion and break-up mechanism with a vertical buoyant jet promoting the turbulent helium transport. Small scale experiment and computational fluid dynamics (CFD) analyses were carried out for investigating this phenomena. In the experiment, a rectangular vessel made with acrylic plates with a width of 1.5 m, a length of 1.5 m and a height of 1.8 m was used for visualizing flow field with particle image velocimetry (PIV) system. The quadrupole mass spectrometer (QMS) system with a multiport rotating valve was applied for measuring gaseous concentration at 20 elevation points. In CFD analysis with OpenFOAM, two typical well-used turbulence models were used: low-Reynolds number type k–ε model and SST k–ω model, with a turbulence model modification to consider the buoyant effect in the stratification. As a result, the stratification erosion in the CFD analyses with the modified turbulence model agreed well with the experimental data, indicating importance of the turbulence damping by the buoyant effect.

  12. EDS V25 containment vessel explosive qualification test report.

    Energy Technology Data Exchange (ETDEWEB)

    Rudolphi, John Joseph

    2012-04-01

    The V25 containment vessel was procured by the Project Manager, Non-Stockpile Chemical Materiel (PMNSCM) as a replacement vessel for use on the P2 Explosive Destruction Systems. It is the first EDS vessel to be fabricated under Code Case 2564 of the ASME Boiler and Pressure Vessel Code, which provides rules for the design of impulsively loaded vessels. The explosive rating for the vessel based on the Code Case is nine (9) pounds TNT-equivalent for up to 637 detonations. This limit is an increase from the 4.8 pounds TNT-equivalency rating for previous vessels. This report describes the explosive qualification tests that were performed in the vessel as part of the process for qualifying the vessel for explosive use. The tests consisted of a 11.25 pound TNT equivalent bare charge detonation followed by a 9 pound TNT equivalent detonation.

  13. Probabilistic atlas based labeling of the cerebral vessel tree

    Science.gov (United States)

    Van de Giessen, Martijn; Janssen, Jasper P.; Brouwer, Patrick A.; Reiber, Johan H. C.; Lelieveldt, Boudewijn P. F.; Dijkstra, Jouke

    2015-03-01

    Preoperative imaging of the cerebral vessel tree is essential for planning therapy on intracranial stenoses and aneurysms. Usually, a magnetic resonance angiography (MRA) or computed tomography angiography (CTA) is acquired from which the cerebral vessel tree is segmented. Accurate analysis is helped by the labeling of the cerebral vessels, but labeling is non-trivial due to anatomical topological variability and missing branches due to acquisition issues. In recent literature, labeling the cerebral vasculature around the Circle of Willis has mainly been approached as a graph-based problem. The most successful method, however, requires the definition of all possible permutations of missing vessels, which limits application to subsets of the tree and ignores spatial information about the vessel locations. This research aims to perform labeling using probabilistic atlases that model spatial vessel and label likelihoods. A cerebral vessel tree is aligned to a probabilistic atlas and subsequently each vessel is labeled by computing the maximum label likelihood per segment from label-specific atlases. The proposed method was validated on 25 segmented cerebral vessel trees. Labeling accuracies were close to 100% for large vessels, but dropped to 50-60% for small vessels that were only present in less than 50% of the set. With this work we showed that using solely spatial information of the vessel labels, vessel segments from stable vessels (>50% presence) were reliably classified. This spatial information will form the basis for a future labeling strategy with a very loose topological model.

  14. Vessel-guided airway tree segmentation

    DEFF Research Database (Denmark)

    Lo, Pechin Chien Pau; Sporring, Jon; Ashraf, Haseem

    2010-01-01

    This paper presents a method for airway tree segmentation that uses a combination of a trained airway appearance model, vessel and airway orientation information, and region growing. We propose a voxel classification approach for the appearance model, which uses a classifier that is trained to di...

  15. 15 CFR 970.205 - Vessel safety.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Vessel safety. 970.205 Section 970.205... safety. In order to provide a basis for the necessary determinations with respect to the safety of life... Safety of Life at Sea, 1974 (SOLAS 74) possesses current valid SOLAS 74 certificates; (2) That any...

  16. 76 FR 55079 - Recreational Vessel Accident Reporting

    Science.gov (United States)

    2011-09-06

    ... operators to make decisions aimed at improving boating safety. This information, described in title 33 Code... Coast Guard long after an accident occurs. Incomplete, inaccurate, or late accident information makes... the recreational vessel owner or operator? If so, how many man-hours are required to collect this...

  17. Eddy current testing of composite pressure vessels

    Science.gov (United States)

    Casperson, R.; Pohl, R.; Munzke, D.; Becker, B.; Pelkner, M.

    2018-04-01

    The use of composite pressure vessels instead of conventional vessels made of steel or aluminum grew strongly over the last decade. The reason for this trend is the tremendous weight saving in the case of composite vessels. However, the long-time behavior is not fully understood for filling and discharging cycles and creep strength and their influence on the CFRP coating (carbon fiber reinforced plastics) and the internal liner (steel, aluminum, or plastics). The CFRP ensures the pressure resistance while the inner liner is used as a container for liquid or gas. To overcome the missing knowledge of aging, BAM started an internal project to investigate degradation of these material systems. Therefore, applicable testing methods like eddy current testing are needed. Normally, high-frequency eddy current testing (HF-ET, f > 10 MHz) is deployed for CFRP due to its low conductivity of the fiber, which is in the order of 0.01 MS/s, and the capacitive coupling between the fibers. Nevertheless, in some cases conventional ET can be applied. We show a concise summary of studies on the application of conventional ET of composite pressure vessels.

  18. Heavy wall pressure vessels for energy systems

    International Nuclear Information System (INIS)

    Canonico, D.A.

    Modifications of steels currently accepted in the Code appear to provide improved mechanical properties. These steels may permit the fabrication of larger diameter vessels with thinner section sizes and improved reliability and integrity. Adapting current specifications should expedite Code approval. Finally the challenge of improving welding procedures and adapting processes for field applications will result in higher quality weldments

  19. Zone separator for multiple zone vessels

    Science.gov (United States)

    Jones, John B.

    1983-02-01

    A solids-gas contact vessel, having two vertically disposed distinct reaction zones, includes a dynamic seal passing solids from an upper to a lower zone and maintaining a gas seal against the transfer of the separate treating gases from one zone to the other, and including a stream of sealing fluid at the seal.

  20. Pressurized water reactor with reactor pressure vessel

    International Nuclear Information System (INIS)

    Werres, L.

    1985-01-01

    The pressure vessel has a cylindrical jacket with a domed floor. A guide is arranged on the domed floor to even out the flow in the core. It consists of a cylindrical jacket, whose lower end has slots and fins. These fins are welded to the domed floor. (orig./PW)

  1. Pressurized water reactor with reactor pressure vessel

    International Nuclear Information System (INIS)

    Werres, L.

    1980-01-01

    The pressure vessel has a cylindrical jacket with a domed floor. A guide is arranged on the domed floor to even out the flow in the core. It consists of a cylindrical jacket, whose lower end has slots and fins. These fins are welded to the domed floor. (DG) [de

  2. Stowing the Right Containers on Container Vessels

    DEFF Research Database (Denmark)

    Jensen, Rune Møller

    2014-01-01

    ’s largest container vessels using standard mathematical programming techniques and off-the-shelf solvers. The presentation will provide basic insight into the domain, with pointers to further information that enable you to join in this promising new path of operations research and business....

  3. Stress criteria for nuclear vessel concrete

    International Nuclear Information System (INIS)

    Costes, D.

    1975-01-01

    Concrete nuclear vessels are submitted to prestressing forces which limit tensile stresses in concrete when the vessel is under pressure with thermal gradients. Hence, the most severe conditions for concrete appear when the vessel is prestressed and not submitted to internal pressure. The triaxial states of stress in the concrete may be computed postulating elastic or other behavior and compared with safe limits obtained from rupture tests and fatigue tests. The first part of the paper, recalls experimental rupture results and the acceptability procedures currently used. Criteria founded on the lemniscoid surfaces are proposed, parameters for which are obtained by various tests and safety considerations. In the second part, rupture tests are reported on small, thick, cylindrical vessels submitted to external hydraulic pressure simulating prestressing forces. Materials used are plain concrete, microconcrete, marble and graphite. The strengths obtained are much higher than those which could be elastically computed, triaxial rupture states being provided by previous experiments. Such results may be due to a plastic stress redistribution before fracture and to stabilizing effects of stress gradients around the more stressed areas. Fatigue tests by external hydraulic loading are reported [fr

  4. On the hydrostatic test for nuclear vessels

    International Nuclear Information System (INIS)

    Palmero, A.

    1979-01-01

    A comparison of the pressure test requirements, namely specified values of pressure and temperature, for nuclear vessels designed and constructed according to the ASME Code and Spanish Rules is presented. Also the relationship of the design criteria and the pressure test requirements is indicated with a particular emphasis on the test temperature in order to avoid brittle behaviour of the materials. (author)

  5. Failure probability analysis on mercury target vessel

    International Nuclear Information System (INIS)

    Ishikura, Syuichi; Futakawa, Masatoshi; Kogawa, Hiroyuki; Sato, Hiroshi; Haga, Katsuhiro; Ikeda, Yujiro

    2005-03-01

    Failure probability analysis was carried out to estimate the lifetime of the mercury target which will be installed into the JSNS (Japan spallation neutron source) in J-PARC (Japan Proton Accelerator Research Complex). The lifetime was estimated as taking loading condition and materials degradation into account. Considered loads imposed on the target vessel were the static stresses due to thermal expansion and static pre-pressure on He-gas and mercury and the dynamic stresses due to the thermally shocked pressure waves generated repeatedly at 25 Hz. Materials used in target vessel will be degraded by the fatigue, neutron and proton irradiation, mercury immersion and pitting damages, etc. The imposed stresses were evaluated through static and dynamic structural analyses. The material-degradations were deduced based on published experimental data. As a result, it was quantitatively confirmed that the failure probability for the lifetime expected in the design is very much lower, 10 -11 in the safety hull, meaning that it will be hardly failed during the design lifetime. On the other hand, the beam window of mercury vessel suffered with high-pressure waves exhibits the failure probability of 12%. It was concluded, therefore, that the leaked mercury from the failed area at the beam window is adequately kept in the space between the safety hull and the mercury vessel by using mercury-leakage sensors. (author)

  6. 78 FR 63235 - Tank Vessel Oil Transfers

    Science.gov (United States)

    2013-10-23

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard [Docket No. USCG-2013-0522] Tank Vessel Oil Transfers... that it is considering new measures to reduce the risks of oil spills in oil transfer operations from...), U.S. Department of Transportation, West Building Ground Floor, Room W12-140, 1200 New Jersey Avenue...

  7. PWR pressure vessel integrity during overcooling accidents

    International Nuclear Information System (INIS)

    Cheverton, R.D.

    1981-01-01

    Pressurized water reactors are susceptible to certain types of hypothetical accidents that under some circumstances, including operation of the reactor beyond a critical time in its life, could result in failure of the pressure vessel as a result of propagation of crack-like defects in the vessel wall. The accidents of concern are those that result in thermal shock to the vessel while the vessel is subjected to internal pressure. Such accidents, referred to as pressurized thermal shock or overcooling accidents (OCA), include a steamline break, small-break LOCA, turbine trip followed by stuck-open bypass valves, the 1978 Rancho Seco and the TMI accidents and many other postulated and actual accidents. The source of cold water for the thermal shock is either emergency core coolant or the normal primary-system coolant. ORNL performed fracture-mechanics calculations for a steamline break in 1978 and for a turbine-trip case in 1980 and concluded on the basis of the results that many more such calculations would be required. To meet the expected demand in a realistic way a computer code, OCA-I, was developed that accepts primary-system temperature and pressure transients as input and then performs one-dimensional thermal and stress analyses for the wall and a corresponding fracture-mechanics analysis for a long axial flaw. The code is briefly described, and its use in both generic and specific plant analyses is discussed

  8. 46 CFR 390.5 - Agreement vessels.

    Science.gov (United States)

    2010-10-01

    ... port to port, excluding equipment that needs frequent replacement due to normal wear and tear, and is... foreign country or points in two different foreign countries in the case of liquid and dry bulk cargo... vessel by means of wheeled technology; and (ii) That is: (A) Loaded at a port in the United States and...

  9. Multiscale Vessel-guided Airway Tree Segmentation

    DEFF Research Database (Denmark)

    Lo, Pechin Chien Pau; Sporring, Jon; de Bruijne, Marleen

    2009-01-01

    This paper presents a method for airway tree segmentation that uses a combination of a trained airway appearance model, vessel and airway orientation information, and region growing. The method uses a voxel classification based appearance model, which involves the use of a classifier that is trai...

  10. Energy and impacts of pressure vessel explosions

    International Nuclear Information System (INIS)

    Kurttila, H.

    1999-01-01

    In this paper the explosion energy is considered to be same as the energy of pressure vessel discharge. This is the maximum energy which can be obtained from the process. The energy can be used or it can cause the violence of an explosion accident. (orig.)

  11. In vessel core melt progression phenomena

    International Nuclear Information System (INIS)

    Courtaud, M.

    1993-01-01

    For all light water reactor (LWR) accidents, including the so called severe accidents where core melt down can occur, it is necessary to determine the amount and characteristics of fission products released to the environment. For existing reactors this knowledge is used to evaluate the consequences and eventual emergency plans. But for future reactors safety authorities demand decrease risks and reactors designed in such a way that fission products are retained inside the containment, the last protective barrier. This requires improved understanding and knowledge of all accident sequences. In particular it is necessary to be able to describe the very complex phenomena occurring during in vessel core melt progression because they will determine the thermal and mechanical loads on the primary circuit and the timing of its rupture as well as the fission product source term. On the other hand, in case of vessel failure, knowledge of the physical and chemical state of the core melt will provide the initial conditions for analysis of ex-vessel core melt progression and phenomena threatening the containment. Finally a good understanding of in vessel phenomena will help to improve accident management procedures like Emergency Core Cooling System water injection, blowdown and flooding of the vessel well, with their possible adverse effects. Research and Development work on this subject was initiated a long time ago and is still in progress but now it must be intensified in order to meet the safety requirements of the next generation of reactors. Experiments, limited in scale, analysis of the TMI 2 accident which is a unique source of global information and engineering judgment are used to establish and assess physical models that can be implemented in computer codes for reactor accident analysis

  12. Role of arginase in vessel wall remodeling

    Directory of Open Access Journals (Sweden)

    William eDurante

    2013-05-01

    Full Text Available Arginase metabolizes the semi-essential amino acid L-arginine to L-ornithine and urea. There are two distinct isoforms of arginase, arginase I and II, which are encoded by separate genes and display differences in tissue distribution, subcellular localization, and molecular regulation. Blood vessels express both arginase I and II but their distribution appears to be cell-, vessel-, and species-specific. Both isoforms of arginase are induced by numerous pathologic stimuli and contribute to vascular cell dysfunction and vessel wall remodeling in several diseases. Clinical and experimental studies have documented increases in the expression and/or activity of arginase I or II in blood vessels following arterial injury and in pulmonary and arterial hypertension, aging, and atherosclerosis. Significantly, pharmacological inhibition or genetic ablation of arginase in animals ameliorates abnormalities in vascular cells and normalizes blood vessel architecture and function in all of these pathological states. The detrimental effect of arginase in vascular remodeling is attributable to its ability to stimulate vascular smooth muscle cell and endothelial cell proliferation, and collagen deposition by promoting the synthesis of polyamines and L-proline, respectively. In addition, arginase adversely impacts arterial remodeling by directing macrophages towards an inflammatory phenotype. Moreover, the proliferative, fibrotic, and inflammatory actions of arginase in the vasculature are further amplified by its capacity to inhibit nitric oxide synthesis by competing with nitric oxide synthase for substrate, L-arginine. Pharmacologic or molecular approaches targeting specific isoforms of arginase represent a promising strategy in treating obstructive fibroproliferative vascular disease.

  13. Comprehending the structure of a vacuum vessel and in-vessel components of fusion machines. 1. Comprehending the vacuum vessel structure

    International Nuclear Information System (INIS)

    Onozuka, Masanori; Nakahira, Masataka

    2006-01-01

    The functions, conditions and structure of vacuum vessel using tokamak fusion machines are explained. The structural standard and code of vacuum vessel, process of vacuum vessel design, and design of ITER vacuum vessel are described. Production and maintenance of ultra high vacuum, confinement of radioactive materials, support of machines in vessel and electromagnetic force, radiation shield, plasma vertical stability, one-turn electric resistance, high temperature baking heat and remove of nuclear heat, reduce of troidal ripple, structural standard, features of safety of nuclear fusion machines, subjects of structural standard of fusion vacuum vessel, design flow of vacuum vessel, establishment of radial build, selections of materials, baking and cooling method, basic structure, structure of special parts, shield structure, and of support structure, and example of design of structure, ITER, are stated. (S.Y.)

  14. Clinical results of single-vessel versus multiple-vessel infrapopliteal intervention

    OpenAIRE

    Darling, Jeremy; McCallum, John C.; Soden, Peter A.; Hon, J.J. (John J.); Guzman, R.J. (Raul J.); Wyers, M.C. (Mark C.); Verhagen, Hence; Schermerhorn, Marc

    2016-01-01

    textabstractObjective The effects of concomitant endovascular interventions on multiple infrapopliteal vessels are not well known, and the short-term and long-term sequelae of such procedures have not been reported. Methods From 2004 to 2014, 673 limbs in 528 patients underwent an infrapopliteal endovascular intervention for tissue loss (77%), rest pain (13%), stenosis of a previously treated vessel (5%), acute limb ischemia (3%), or claudication (2%). Outcomes included wound healing, RAS eve...

  15. Heat treatment device for extending the life of a pressure vessel, particularly a reactor pressure vessel

    International Nuclear Information System (INIS)

    Krauss, P.; Mueller, E.; Poerner, H.; Weber, R.

    1979-01-01

    A support body in the form of an insulating cylinder is tightly sealed by connected surfaces at its outer circumference to the inner wall of the pressure vessel. It forms an annular heating space. The heat treatment or tempering of the pressure vessel takes place with the reactor space empty and screened from the outside by ceiling bolts. Heating gas or an induction winding can be used as the means of heating. (DG) [de

  16. Sealing method and sealing device for radioactive waste containing vessel

    International Nuclear Information System (INIS)

    Ishiwatari, Koji; Otsuki, Akira

    1998-01-01

    A radioactive waste-containing body is hoisted down into a strong-material vessel opened upwardly, and a strong-material lid is hoisted down to the opening of the strong-material-vessel and welded. The strong material vessel is hoisted up and loaded on a corrosion resistant-material bottom plate placed horizontally. A corrosion resistant-material vessel having one opening end and having a corrosion resistant-material flange on the other end and previously agreed with the strong material-vessel main body is hoisted up by a hoisting device having an inserting device so that the opening of the corrosion resistant vessel is directed downwardly. The corrosion resistant vessel is press-fitted to the outside of the strong material-vessel by the inserting device while being heated by a preheater to shrink. Subsequently, the lower end of the corrosion resistant-material vessel and the corrosion resistant-material bottom plate are welded to constitute a corrosion resistant-material vessel. Then, the radioactive waste containing body can be sealed in a sealing vessel comprising the strong-material vessel and the corrosion resistant-material vessel. (N.H.)

  17. Prestressed cast iron pressure vessels as burst-proof pressure vessels for innovative nuclear applications

    International Nuclear Information System (INIS)

    Froehling, W.; Boettcher, A.; Bounin, D.; Steinwarz, W.; Geiss, M.; Trauth, M.

    2000-01-01

    The amendment to the German Atomic Energy Act from July 28, 1994 requires that events 'whose occurrence is practically excluded by the measures against damages', i.e. events of the category residual risk, must not necessitate far reaching protective measures outside the plant. For a conventional reactor pressure vessel, the residual risk consists in the very small probability of a catastrophic failure (formation of a large fracture opening, bursting of the vessel). With a prestressed cast iron vessel (PCIV), the formation of a large fracture opening or bursting of the vessel, respectively, is impossible due to its design properties. Against this background the possibility of the use of this type of pressure vessel for lightwater reactors has been studied in the frame of a 'Working Group for Innovative Nuclear Technology', founded by different research institutes and industrial companies. Furthermore, it has been studied whether the use of the PCIV support the realization of a corecatcher system. The results are presented in this report. Already many years earlier, Siempelkamp has performed industrial development and Forschungszentrum Juelich related experimental and theoretical safety research for the PCIV as an innovative, bust-proof pressure vessel concept. This development of the PCIV as well as its safety properties are also presented in a conclusive manner. (orig.) [de

  18. 75 FR 38878 - Transportation for Individuals With Disabilities: Passenger Vessels

    Science.gov (United States)

    2010-07-06

    ..., excursion vessels, sightseeing vessels, floating restaurants, cruise ships, and others. Cruise ships are a... the PVO owns or leases the terminal or exercises control over its selection, design, construction, or...

  19. Liquid metal systems development: reactor vessel support structure evaluation

    International Nuclear Information System (INIS)

    McEdwards, J.A.

    1981-01-01

    Results of an evaluation of support structures for the reactor vessel are reported. The U ring, box ring, integral ring, tee ring and tangential beam supports were investigated. The U ring is the recommended vessel support structure configuration

  20. 19 CFR 4.60 - Vessels required to clear.

    Science.gov (United States)

    2010-04-01

    ... contiguous country otherwise than by sea. (c) Vessels which will merely transit the Panama Canal without... of clearance and related papers shall be surrendered. (e) No vessel shall be cleared for the high...

  1. 33 CFR 157.450 - Maneuvering and vessel status information.

    Science.gov (United States)

    2010-07-01

    ... SECURITY (CONTINUED) POLLUTION RULES FOR THE PROTECTION OF THE MARINE ENVIRONMENT RELATING TO TANK VESSELS CARRYING OIL IN BULK Interim Measures for Certain Tank Vessels Without Double Hulls Carrying Petroleum Oils...

  2. Pericyte coverage of abnormal blood vessels in myelofibrotic bone marrows

    DEFF Research Database (Denmark)

    Zetterberg, Eva; Vannucchi, Alessandro M; Migliaccio, Anna Rita

    2007-01-01

    BACKGROUND AND OBJECTIVES: Myelofibrotic bone marrow displays abnormal angiogenesis but the pathogenic mechanisms of this are poorly understood. Since pericyte abnormalities are described on solid tumor vessels we studied whether vessel morphology and pericyte coverage in bone marrow samples from...

  3. Report of the DHS Small Vessel Security Institute

    National Research Council Canada - National Science Library

    Brownstein, Charles; Baker, John; Hull, Peter; Minogue, Nicholas; Murphy, George; Winston, Phyllis

    2007-01-01

    The purpose of the National Small Vessel Security Summit (NSVSS) was to engage private, commercial and government stakeholders in discussions on a range of issues involving the security risks posed by small vessels in the U.S...

  4. Report of the DHS National Small Vessel Security Summit

    National Research Council Canada - National Science Library

    Brownstein, Charles; Baker, John; Hull, Peter; Minogue, Nicholas; Murphy, George; Winston, Phyllis

    2007-01-01

    The purpose of the National Small Vessel Security Summit (NSVSS) was to engage private, commercial and government stakeholders in discussions on a range of issues involving the security risks posed by small vessels in the U.S...

  5. TMI-2 reactor vessel plenum final lift

    International Nuclear Information System (INIS)

    Wilson, D.C.

    1986-01-01

    Removal of the plenum assembly from the TMI-2 reactor vessel was necessary to gain access to the core region for defueling. The plenum was lifted from the reactor vessel by the polar crane using three specially designed pendant assemblies. It was then transferred in air to the flooded deep end of the refueling canal and lowered onto a storage stand where it will remain throughout the defueling effort. The lift and transfer were successfully accomplished on May 15, 1985 in just under three hours by a lift team located in a shielded area within the reactor building. The success of the program is attributed to extensive mockup and training activities plus thorough preparations to address potential problems. 54 refs

  6. TMI-2 reactor vessel head removal

    International Nuclear Information System (INIS)

    Bengel, P.R.; Smith, M.D.; Estabrook, G.A.

    1984-12-01

    This report describes the safe removal and storage of the Three Mile Island Unit 2 reactor vessel head. The head was removed in July 1984 to permit the removal of the plenum and the reactor core, which were damaged during the 1979 accident. From July 1982, plans and preparations were made using a standard head removal procedure modified by the necessary precautions and changes to account for conditions caused by the accident. After data acquisition, equipment and structure modifications, and training the head was safely removed and stored and the internals indexing fixture and a work platform were installed on top of the vessel. Dose rates during and after the operation were lower than expected; lessons were learned from the operation which will be applied to the continuing fuel removal operations activities

  7. Imaging Blood Vessel Morphology in Skin

    DEFF Research Database (Denmark)

    Schuh, Sandra; Holmes, Jon; Ulrich, Martina

    2017-01-01

    Conventional optical coherence tomography (OCT) enables the visualization of morphological changes of skin cancer. The use of OCT in the diagnostic investigation and in the therapy decision of non-melanoma skin cancer and other skin changes is already established, and has found its way into routine...... practice. With the development of speckle-variance OCT, also named dynamic OCT (D-OCT), the vascular architecture and the blood flow of the skin can be displayed in vivo and in 3D. This novel angiographic variant of OCT offers the ability to visualize and measure vessel morphology providing a new insight...... into healthy, inflammatory and neoplastic skin lesions such as malignant melanoma. This review focuses on the possibilities of using D-OCT on healthy and diseased skin. We suggest and illustrate key diagnostic characteristics by analyzing the initial publications and preliminary unpublished data on vessel...

  8. Immersive volume rendering of blood vessels

    Science.gov (United States)

    Long, Gregory; Kim, Han Suk; Marsden, Alison; Bazilevs, Yuri; Schulze, Jürgen P.

    2012-03-01

    In this paper, we present a novel method of visualizing flow in blood vessels. Our approach reads unstructured tetrahedral data, resamples it, and uses slice based 3D texture volume rendering. Due to the sparse structure of blood vessels, we utilize an octree to efficiently store the resampled data by discarding empty regions of the volume. We use animation to convey time series data, wireframe surface to give structure, and utilize the StarCAVE, a 3D virtual reality environment, to add a fully immersive element to the visualization. Our tool has great value in interdisciplinary work, helping scientists collaborate with clinicians, by improving the understanding of blood flow simulations. Full immersion in the flow field allows for a more intuitive understanding of the flow phenomena, and can be a great help to medical experts for treatment planning.

  9. Investigation of impulsively loaded pressure vessels

    Energy Technology Data Exchange (ETDEWEB)

    Brown, N.; Cornwell, R.; Hanner, D.; Leichter, H.; Mohr, P.

    1963-10-15

    Explosion containment vessels for containing from 2,000 to 3,000 five ton nuclear explosions are considered. Analysis methods appear adequate and lowest weights using the most advanced materials available in the next five years are projected.None of these materials can be fabricated today and all require extensive development. Present material technology limits the choice of materials and defines the weight. The addition of safety factors and fixtures (nozzles, etc.) will add to this weight considerably, and may well radically alter the vessel response. Improvements in the strength weight ratios of metals and glasses over those considered in this report do not appear reasonable at this time. Winding schemes to utilize the high strength of steel wires and somehow maintain a reasonable thickness appear to offer the most promise. A `ductile` beryllium would of course offer vast improvement, but no indications that this is being developed have appeared and all presently known beryllium is much too brittle.

  10. Results of steel containment vessel model test

    International Nuclear Information System (INIS)

    Luk, V.K.; Ludwigsen, J.S.; Hessheimer, M.F.; Komine, Kuniaki; Matsumoto, Tomoyuki; Costello, J.F.

    1998-05-01

    A series of static overpressurization tests of scale models of nuclear containment structures is being conducted by Sandia National Laboratories for the Nuclear Power Engineering Corporation of Japan and the US Nuclear Regulatory Commission. Two tests are being conducted: (1) a test of a model of a steel containment vessel (SCV) and (2) a test of a model of a prestressed concrete containment vessel (PCCV). This paper summarizes the conduct of the high pressure pneumatic test of the SCV model and the results of that test. Results of this test are summarized and are compared with pretest predictions performed by the sponsoring organizations and others who participated in a blind pretest prediction effort. Questions raised by this comparison are identified and plans for posttest analysis are discussed

  11. Vacuum vessel for a nuclear fusion device

    International Nuclear Information System (INIS)

    Watanabe, Takashi; Sato, Hiroshi; Owada, Koro.

    1976-01-01

    Object: To provide a reinforcing member on a bellows portion to reduce a stress at the bellows portion thereby increasing the strength of a vessel. Structure: A vacuum vessel for a nuclear fusion device has a bellows portion and a wall thick portion. A support extended toward the bellows portion is secured inside of a toroidal section in order to reduce the stress at the bellows portion. An insulator is interposed between the support and the bellows portion and is retained on the support by a bolt. Since the stress may be reduced by the support, the wall thick of the bellows portion may be decreased to sufficiently secure the low electric resistance value. (Yoshihara, H.)

  12. TMI-2 reactor vessel head removal

    International Nuclear Information System (INIS)

    Bengel, P.R.; Smith, M.D.; Estabrook, G.A.

    1985-09-01

    This report describes the safe removal and storage of the Three Mile Island Unit 2 (TMI-2) reactor vessel head. The head was removed in July 1984 to permit the removal of the plenum and the reactor core, which were damaged during the 1979 accident. From July 1982, plans and preparations were made using a standard head removal procedure modified by the necessary precautions and changes to account for conditions caused by the accident. After data acquisition, equipment and structure modifications, and training, the head was safely removed and stored; and the internals indexing fixture and a work platform were installed on top of the vessel. Dose rates during and after the operation were lower than expected; lessons were learned from the operation which will be applied to the continuing fuel removal operations activities

  13. Status of the ITER vacuum vessel construction

    Energy Technology Data Exchange (ETDEWEB)

    Choi, C.H.; Sborchia, C.; Ioki, K.; Giraud, B.; Utin, Yu.; Sa, J.W. [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France); Wang, X., E-mail: xiaoyuwww@gmail.com [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France); Teissier, P.; Martinez, J.M.; Le Barbier, R.; Jun, C.; Dani, S.; Barabash, V.; Vertongen, P.; Alekseev, A. [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France); Jucker, P.; Bayon, A. [F4E, c/ Josep Pla, n. 2, Torres Diagonal Litoral, Edificio B3, E-08019 Barcelona (Spain); Pathak, H.; Raval, J. [ITER-India, IPR, A-29, Electronics Estate, GIDC, Sector-25, Gandhinagar 382025 (India); Ahn, H.J. [ITER Korea, National Fusion Research Institute, Daejeon (Korea, Republic of); and others

    2014-10-15

    Highlights: • Final design of the ITER vacuum vessel (VV). • Procurement of the ITER VV. • Manufacturing results of real scale mock-ups. • Manufacturing status of the VV in domestic agencies. - Abstract: The ITER vacuum vessel (VV) is under manufacturing by four domestic agencies after completion of engineering designs that have been approved by the Agreed Notified Body (ANB). Manufacturing designs of the VV have been being completed, component by component, by accommodating requirements of the RCC-MR 2007 edition. Manufacturing of the VV first sector has been started in February 2012 in Korea and in-wall shielding in May 2013 in India. EU will start manufacturing of its first sector from September 2013 and Russia the upper port by the end of 2013. All DAs have manufactured several mock-ups including real-size ones to justify/qualify and establish manufacturing techniques and procedures.

  14. Autonomous radiation monitoring of small vessels

    International Nuclear Information System (INIS)

    Ziock, K.P.; Cheriyadat, A.; Fabris, L.; Goddard, J.; Hornback, D.; Karnowski, T.; Kerekes, R.; Newby, J.

    2011-01-01

    Small private vessels are one avenue by which nuclear materials may be smuggled across international borders. While one can contemplate using the land-based approach of radiation portal monitors on the navigable waterways that lead to many ports, these systems are ill-suited to the problem. In contrast to roadways, where lanes segregate vehicles, and motion is well controlled by inspection booths; channels, inlets, and rivers present chaotic traffic patterns populated by vessels of all sizes. A unique solution to this problem is based on a portal-less portal monitor designed to handle free-flowing traffic on roadways with up to five-traffic lanes. The instrument uses a combination of visible-light and gamma-ray imaging to acquire and link radiation images to individual vehicles. This paper presents the results of a recent test of the system in a maritime setting.

  15. Rapid construction of concrete pressure vessels

    International Nuclear Information System (INIS)

    Limbert, D.; Weatherseed, D.C.

    1989-01-01

    This paper opens with a general description of the concrete pressure vessel followed by a more detailed examination of the critical elements of the construction, including choice of methods and plant which were selected to ensure its rapid construction. The pressure vessel construction cannot be treated in isolation, because it is very closely linked with its surrounding structures - namely the reactor hall which surrounds it and the charge hall which tops it, as will be seen in the context of this paper. Rate of progress of construction is not entirely in the civil contractor's hands because so many of the operations affecting the civil works are of a mechanical nature, hence a very close liaison and understanding amongst all contractors concerned was of the utmost importance. (author)

  16. Computing the partial volume of pressure vessels

    Energy Technology Data Exchange (ETDEWEB)

    Wiencke, Bent [Nestle USA, Corporate Engineering, 800 N. Brand Blvd, Glendale, CA 91203 (United States)

    2010-06-15

    The computation of the partial and total volume of pressure vessels with various type of head profiles requires detailed knowledge of the head profile geometry. Depending on the type of head profile the derivation of the equations can become very complex and the calculation process cumbersome. Certain head profiles require numerical methods to obtain the partial volume, which for most application is beyond the scope of practicability. This paper suggests a unique method that simplifies the calculation procedure for the various types of head profiles by using one common set of equations without the need for numerical or complex computation methods. For ease of use, all equations presented in this paper are summarized in a single table format for horizontal and vertical vessels. (author)

  17. Starting procedure for internal combustion vessels

    Science.gov (United States)

    Harris, Harry A.

    1978-09-26

    A vertical vessel, having a low bed of broken material, having included combustible material, is initially ignited by a plurality of ignitors spaced over the surface of the bed, by adding fresh, broken material onto the bed to buildup the bed to its operating depth and then passing a combustible mixture of gas upwardly through the material, at a rate to prevent back-firing of the gas, while air and recycled gas is passed through the bed to thereby heat the material and commence the desired laterally uniform combustion in the bed. The procedure permits precise control of the air and gaseous fuel mixtures and material rates, and permits the use of the process equipment designed for continuous operation of the vessel.

  18. Design and analysis of prestressed reactor vessels

    International Nuclear Information System (INIS)

    Burrow, R.E.D.

    1978-01-01

    This review is intended to draw attention to subjects of interest from papers given at two sessions of the SMiRT 4 conference. The first of these is the structural engineering of prestressed reactor vessels. The topics include developments in the general design of prestressed vessels, structural analysis of PCVRs, model tests and design of penetration, closures and liners for PCVRs. The question of gas cracks was amongst other issues raised. The second of the sessions was concerned with loading conditions and structural analysis of reactor containment. Reference is made to a variety of topics discussed in this session. Particular attention is given to the effects caused by missiles. In concluding, the reviewer suggests the need for a critical assessment of the existing mass of information to sort out the essentials and to bring back some simplicity into design analysis. (UK)

  19. Irradiation embrittlement of pressure vessel steels

    International Nuclear Information System (INIS)

    Brumovsky, M.; Vacek, M.

    1975-01-01

    A Standard Research Programme on Irradiation Embrittlement of Pressure Vessel Steels was approved by the Coordinating Meeting on the 12th May 1972 at the Working Group on Engineering Aspects of Irradiation Embrittlement of Pressure Vessel Steels. This Working Group was set up by the International Atomic Energy Agency in Vienna. Seven countries with their research institutes agreed on doing irradiation experiments according to the approved programme on steel A533 B from the U.S. HSST Programme. The Czechoslovak contribution covering tensile and impact testing of non-irradiated steel and steel irradiated at 280degC to 1.3 x 10 23 n/m 2 (E above 1 MeV) is presented in this report. As an additional part the same set of experiments was carried out on two additional steels - A 542 and A 543, made in SKODA Works for comparison of their irradiation embrittlement and hardening with A533 B steel. (author)

  20. Containment vessel for a nuclear reactor

    International Nuclear Information System (INIS)

    Yamanari, Sh.; Horiuchi, T.; Sugisaki, T.; Tominaga, K.

    1985-01-01

    A containment vessel for a nuclear reactor having a dry well for mounting therein a pressure vessel for containing the nuclear reactor, a pressure suppressing chamber having a pool of coolant therein, and a vent pipe device for releasing therethrough into the pool of coolant within the pressure suppressing chamber steam which will be produced as a result of the occurrence of an accident and escape into the dry well. The vent pipe device includes a plurality of vent pipe members inserted in the pool of coolant within the pressure suppressing chamber and each having at least one exhaust port opening in the coolant. The vent pipe members are divided into a plurality of groups in such a manner that the vent pipe members of different groups differ from one another in the length of submerged portions of the vent pipe members interposed between the liquid of the coolant within the pressure suppressing chamber and the exhaust ports of the vent pipe members