Transition probabilities and dissociation energies of MnH and MnD molecules

International Nuclear Information System (INIS)

Nagarajan, K.; Rajamanickam, N.

1997-01-01

The Frank-Condon factors (vibrational transition probabilities) and r-centroids have been evaluated by the more reliable numerical integration procedure for the bands of A-X system of MnH and MnD molecules, using a suitable potential. By fitting the Hulburt- Hirschfelder function to the experimental potential curve using correlation coefficient, the dissociation energy for the electronic ground states of MnH and MnD molecules, respectively have been estimated as D 0 0 =251±5 KJ.mol -1 and D 0 0 =312±6 KJ.mol -1 . (authors)

From symptom onset to a diagnosis of amyotrophic lateral sclerosis/motor neuron disease (ALS/MND): experiences of people with ALS/MND and family carers - a qualitative study.

Science.gov (United States)

O'Brien, Mary R; Whitehead, Bridget; Jack, Barbara A; Mitchell, John Douglas

2011-03-01

Our objectives were to explore the personal perspectives of the diagnostic experience for people with ALS/MND and their family carers identifying issues that could impact positively or negatively on these experiences. We conducted a qualitative study with face-to-face interviews to capture experiences from 24 people with ALS/MND and 18 current family carers. Ten former family carers were also interviewed. The diagnostic experience was fraught with difficulties. There was failure to recognize the significance of some symptoms by patients, carers and primary and secondary care health professionals, which ultimately delayed diagnosis. Delivery of the diagnosis was frequently unsatisfactory despite international guidelines on the subject. Immediate post-diagnosis support often compared negatively to that provided for people with cancer. In conclusion, this study has identified a need for a more streamlined and empathetic diagnostic pathway for people with ALS/MND. Improvements to medical curricula are required to increase awareness of the condition and reduce the likelihood of diagnostic delays resulting from a failure to recognize the need for a neurological referral. Greater public awareness of the illness is also needed. Furthermore, delivery of the diagnosis should more closely adhere to established guidelines.

AGU Panel meets on career topics

Science.gov (United States)

Hollister, Charles

Graduate students and their career opportunities in ocean and earth sciences were the focus of the Education and Human Resources (E & HR) Committee meeting held at the 1982 AGU Fall Meeting in San Francisco. A standing committee of AGU, the E & HR committee is responsible for matters concerning education in earth, ocean, and planetary sciences from precollege through graduate programs, including career guidance, academic preparation, student recruitment, and manpower supply and demand.At the meeting a draft of the AGU-sponsored Careers in Oceanography booklet by committee chairman C. Hollister was thoroughly discussed and a new draft will emerge soon for final approval. The booklet is designed to complement the Careers in Geophysics booklet recently published by AGU; the booklets contain information about planning a career, job opportunities, educational requirements, and a synopsis of where the prospective student might apply.

New software system to improve AGU membership management

Science.gov (United States)

McEntee, Chris

2012-06-01

Almost 2 years ago, AGU began investigating how it could more efficiently manage member and customer records as well as support processes that currently run on multiple systems. I am pleased to announce that on 25 June, as the result of intense efforts, AGU will migrate to a new database software system that will house the majority of AGU operations. AGU staff will have more tools at their disposal to assist members, and members will have more intuitive and user-friendly options when using the online interface to update their profiles or make purchases. I am particularly excited about this major improvement to our infrastructure because it better positions AGU to achieve goals in its strategic plan.

Georneys joins AGU's blog network

Science.gov (United States)

Viñas, Maria-José

2011-07-01

A blog on geological musings, wanderings, and adventures, called Georneys, has joined AGU's network of Earth and space science blogs. With the addition of Georneys, on 11 July, the AGU Blogosphere (http://blogs.agu.org), as the network is known, has grown to showcase eight independent blogs since its launch last fall. “One reason I write this blog is to maintain my sanity as I finish up my Ph.D. In the midst of much stress, long days in lab, and long nights writing thesis chapters, I write to remind myself of why I love geology,” says Georneys blogger Evelyn Mervine. “I also write to document some of my geological adventures and to share my love of geology with others.”

Notification of upcoming AGU Council meeting

Science.gov (United States)

Williams, Billy

2012-10-01

The AGU Council will meet on Sunday, 2 December 2012, at the InterContinental Hotel in San Francisco, Calif. The meeting, which is open to all AGU members, will include discussions of AGU's new Grand Challenge Project (a project that will be introduced to members at the 2012 Fall Meeting), the proposed AGU scientific ethics policy, publishing strategies, future plans for honors and recognition, and leadership transition as new members join the Council. This year the Council experimented with a new approach to conducting business. By holding virtual meetings throughout the year, Council members have been able to act in a more timely manner and provide input on important membership and science issues on the Board of Directors' agenda. The Council Leadership Team—an elected subset of the Council—also experimented with a new approach, meeting every month to keep moving projects forward. This approach has increased communication and improved effectiveness in Council decision making.

Assessing social isolation in motor neurone disease: a Rasch analysis of the MND Social Withdrawal Scale.

Science.gov (United States)

Gibbons, Chris J; Thornton, Everard W; Ealing, John; Shaw, Pamela J; Talbot, Kevin; Tennant, Alan; Young, Carolyn A

2013-11-15

Social withdrawal is described as the condition in which an individual experiences a desire to make social contact, but is unable to satisfy that desire. It is an important issue for patients with motor neurone disease who are likely to experience severe physical impairment. This study aims to reassess the psychometric and scaling properties of the MND Social Withdrawal Scale (MND-SWS) domains and examine the feasibility of a summary scale, by applying scale data to the Rasch model. The MND Social Withdrawal Scale was administered to 298 patients with a diagnosis of MND, alongside the Hospital Anxiety and Depression Scale. The factor structure of the MND Social Withdrawal Scale was assessed using confirmatory factor analysis. Model fit, category threshold analysis, differential item functioning (DIF), dimensionality and local dependency were evaluated. Factor analysis confirmed the suitability of the four-factor solution suggested by the original authors. Mokken scale analysis suggested the removal of item five. Rasch analysis removed a further three items; from the Community (one item) and Emotional (two items) withdrawal subscales. Following item reduction, each scale exhibited excellent fit to the Rasch model. A 14-item Summary scale was shown to fit the Rasch model after subtesting the items into three subtests corresponding to the Community, Family and Emotional subscales, indicating that items from these three subscales could be summed together to create a total measure for social withdrawal. Removal of four items from the Social Withdrawal Scale led to a four factor solution with a 14-item hierarchical Summary scale that were all unidimensional, free for DIF and well fitted to the Rasch model. The scale is reliable and allows clinicians and researchers to measure social withdrawal in MND along a unidimensional construct. © 2013. Published by Elsevier B.V. All rights reserved.

Pandivere kõrgustikule tuulepargid sobivad / Alan Senkel, Jaan Tepp ; interv. Raivo Raigna

Index Scriptorium Estoniae

Senkel, Alan

2008-01-01

Windpower Eesti OÜ juhatuse liige Alan Senkel ja Eesti Tuuleenergia Assotsiatsiooni esimees Jaan Tepp tuuleenergia kasutamisest Eestis. Vt. samas: Raivo Raigna. Kullengale tuulegeneraatorite rajamine kütab kohalike elanike kirgi

Fourier transform infrared emission spectra of MnH and MnD

Science.gov (United States)

Gordon, Iouli E.; Appadoo, Dominique R. T.; Shayesteh, Alireza; Walker, Kaley A.; Bernath, Peter F.

2005-01-01

Fourier transform infrared emission spectra of MnH and MnD were observed in the ground X7Σ + electronic state. The vibration-rotation bands from v = 1 → 0 to v = 3 → 2 for MnH and from v = 1 → 0 to v = 4 → 3 for MnD were recorded at an instrumental resolution of 0.0085 cm -1. Spectroscopic constants were determined for each vibrational level and equilibrium constants were found from a Dunham-type fit. The equilibrium vibrational constant ( ωe) for MnH was found to be 1546.84518(65) cm -1, the equilibrium rotational constant ( Be) is 5.6856789(103) cm -1 and the eqilibrium bond distance ( re) was determined to be 1.7308601(47) Å.

Entering a New ERA: Education Resources and AGU

Science.gov (United States)

Karsten, J. L.; Johnson, R. M.

2001-12-01

Professional societies play a unique role in the on-going battle to improve public education in the Earth and space sciences. With guidance from its Committee on Education and Human Resources (CEHR), AGU has traditionally sponsored strong programs that provide mechanisms for linking its research membership with the formal/informal science education communities. Among the most successful of these are tutorials for K-12 teachers taught by AGU members during national meetings (e.g., GIFT - Geophysical Information For Teachers) and internships that allow teachers to experience geophysical science research first-hand (e.g., STaRS - Science Teacher and Research Scientist). AGU also co-sponsors major symposia to discuss and develop strategies for Earth science education reform (e.g., the NSF-sponsored Shaping the Future workshop) and provides an annual forum for the Heads and Chairs of undergraduate geoscience departments to discuss common problems and share solutions. In the fall of 2001, AGU expects to unveil a major new education and outreach website that will provide enhanced opportunities for communicating to students, teachers and the public about AGU members' research and new directions in geophysical science education. The most important contribution that AGU makes, however, is to validate and prominently endorse the education and outreach efforts of its members, both by sponsoring well-attended, education-related special sessions at AGU national meetings and by annually honoring individuals or groups with the Excellence in Geoscience Education award. Recent staff changes at AGU headquarters have brought new opportunities to expand upon these successful existing programs and move in other directions that capitalize on the strengths of the organization. Among new initiatives being considered are programs that partner education efforts with those being developed as part of several large research programs, curriculum modules that will promote teaching earth sciences

AGU Public Affairs: How to Get Involved in Science Policy

Science.gov (United States)

Landau, E. A.; Hankin, E. R.; Uhlenbrock, K. M.

2012-12-01

AGU Public Affairs offers many ways for its members to get involved in science policy at different levels of participation, whether you would love to spend a year working as a resident science expert in a congressional office in Washington, D.C., or would rather simply receive email alerts about Earth and space science policy news. How you can get involved: Sign up for AGU Science Policy Alerts to receive the most relevant Earth and space science policy information delivered to your email inbox. Participate in one of AGU's Congressional Visits Days to speak with your legislators about important science issues. Attend the next AGU Science Policy Conference in spring 2013. Participate in events happening on Capitol Hill, and watch video of past events. Learn about AGU Embassy Lectures, where countries come together to discuss important Earth and space science topics. Learn how you can comment on AGU Position Statements. Apply to be an AGU Congressional Science Fellow, where you can work in a congressional office for one year and serve as a resident science expert, or to be an AGU Public Affairs Intern, where you can work in the field of science policy for three months. The AGU Public Affairs Team will highlight ways members can be involved as well as provide information on how the team is working to shape policy and inform society about the excitement of AGU science.

Inaugural AGU Science Policy Conference

Science.gov (United States)

Uhlenbrock, Kristan

2012-01-01

AGU will present its inaugural Science Policy Conference, 30 April to 3 May 2012, at the Ronald Reagan Building and International Trade Center, located in downtown Washington, D. C. This conference will bring together leading scientists, policy makers, industry professionals, press, and other stakeholders to discuss natural hazards, natural resources, oceans, and Arctic science and the role these sciences play in serving communities. To bridge the science and policy fields, AGU plans to host this conference every 2 years and focus on the applications of Earth and space sciences to serve local and national communities. "Our nation faces a myriad of challenges such as the sustainability of our natural resources, current and future energy needs, and the ability to mitigate and adapt to natural and manmade hazards," said Michael McPhaden, president of AGU. "It is essential that policies to address these challenges be built on a solid foundation of credible scientific knowledge."

Newly established AGU awards and lecture

Science.gov (United States)

Paredes, Beth; Kumar, Mohi

2012-05-01

The Sulzman Award for Excellence in Education and Mentoring (Biogeosciences section) recognizes AGU members who have sustained an active research career in a field related to biogeosciences while excelling as teachers and serving as role models for the next generation of female scientists. This new award acknowledges the importance of female mentors in enhancing gender balance in physical science career paths. The award is being endowed to honor Elizabeth Sulzman, an isotope biogeochemist and soil scientist, whose enthusiasm for teaching awed many undergraduates at Oregon State University. Current plans are to present the first Sulzman award at the 2013 Fall Meeting. Applicants must be women who are within 15 years of receiving their Ph.D., and nomination packages should include a cover letter, resumé, and three letters of recommendation. As they become available, more details will be posted on the Biogeosciences section Web site (http://www.agu.org/sections/biogeo/). The award will provide up to $1000 to one successful nominee each year, although the exact monetary amount is yet to be determined. AGU is currently accepting donations to endow this award; contact Victoria Thompson (vthompson@agu.org) to get involved.

AGU's Updated Scientific Integrity and Professional Ethics Policy

Science.gov (United States)

McPhaden, M. J.

2017-12-01

AGU'S mission is to promote discovery in Earth and space science for the benefit of humanity. This mission can only be accomplished if all those engaged in the scientific enterprise uphold the highest standards of scientific integrity and professional ethics. AGU's Scientific Integrity and Professional Ethics Policy provides a set of principles and guidelines for AGU members, staff, volunteers, contractors, and non-members participating in AGU sponsored programs and activities. The policy has recently been updated to include a new code of conduct that broadens the definition of scientific misconduct to include discrimination, harassment, and bullying. This presentation provides the context for what motivated the updated policy, an outline of the policy itself, and a discussion of how it is being communicated and applied.

Tantsuime: märjaks nutetud Märt Agu saab 8000 uut sõpra / Märt Agu ; intervjueerinud Rein Sikk

Index Scriptorium Estoniae

Agu, Märt, 1980-

2011-01-01

11. Noorte tantsupeo "Maa ja ilm" üldjuht ja Tallinna Tantsuakadeemia kunstiline juht Märt Agu Tallinna lauluväljakul toimuvast tantsupeost, ülevaatustest, eesti meeste rahvatantsust, oma isast Mait Agust, tema tantsust "Põhjamaa", tantsuõpetaja elukutsest, eesti tantsust, Tallinna Tantsuakadeemiast. Andmeid Märt Agu loomingu kohta

Uniaxial low cycle fatigue behavior for pre-corroded 16MND5 bainitic steel in simulated pressurized water reactor environment

Science.gov (United States)

Chen, Xu; Ren, Bin; Yu, Dunji; Xu, Bin; Zhang, Zhe; Chen, Gang

2018-06-01

The effects of uniaxial tension properties and low cycle fatigue behavior of 16MND5 bainitic steel cylinder pre-corroded in simulated pressurized water reactor (PWR) were investigated by fatigue at room temperature in air and immersion test system, scanning electron microscopy (SEM), energy disperse spectroscopy (EDS). The experimental results indicated that the corrosion fatigue lives of 16MND5 specimen were significantly affected by the strain amplitude and simulated PWR environments. The compositions of corrosion products were complexly formed in simulated PWR environments. The porous corrosion surface of pre-corroded materials tended to generate pits as a result of promoting contact area to the fresh metal, which promoted crack initiation. For original materials, the fatigue cracks initiated at inclusions imbedded in the micro-cracks. Moreover, the simulated PWR environments degraded the mechanical properties and low cycle fatigue behavior of 16MND5 specimens remarkably. Pre-corrosion of 16MND5 specimen mainly affected the plastic term of the Coffin-Manson equation.

Mis on teie maakonna Pisa testi edu võti? / Raivo Peeters, Ivi Remmelg, Monika Adamson

Index Scriptorium Estoniae

Peeters, Raivo

2014-01-01

Küsimusele vastavad Saare maavalitsuse haridus- ja sotsiaalosakonna juhataja Raivo Peeters, Hiiu maavalitsuse haridusnõunik Ivi Remmelg, Põlva maavalitsuse haridus- ja sotsiaalosakonna peaspetsialist Monika Adamson

Rotermanni laudsepatöökoda = Rotermann cabinetmarker's workshop / Raivo Kotov, Andrus Kõresaar

Index Scriptorium Estoniae

Kotov, Raivo, 1976-

2009-01-01

Tallinna endise Rotermanni tööstuskvartali arhitektuuri kaasajastamine. Olemasoleva laudsepatöökoja kohale kavandati kolm eraldiseisvat majakat. Arhitektid Andrus Kõresaar ja Raivo Kotov (KOKO Arhitektid), konstruktorid Marti Sein ja Matis Teeäär, reklaamibüroo Brand Manuali kontori sisekujundaja Maarja Mikkin

New AGU Executive Director Outlines Goals and Priorities

Science.gov (United States)

Showstack, Randy

2010-04-01

When Christine W. McEntee takes the helm at AGU as the new executive director on 30 August, she will bring with her a number of key qualities: more than 25 years of successful association leadership and management experience, a passion for the Earth and space sciences to benefit humanity, a commitment to working to ensure the planet's sustainability, a respect for AGU's distinguished legacy, and the desire and ability to help AGU grow to a higher level of effectiveness. “I have always liked to work in professional associations that are solid and strong and want to go to their next level of excellence—that is where my sweet spot is in being an association executive—and that is what AGU wants to do. So I am very excited about that: a match with what I really enjoy and get passionate about doing in an area that I really care about,” McEntee told Eos in an in-depth interview.

Eesti pärast eurot - milline uus edulugu? / Raivo Vare

Index Scriptorium Estoniae

Vare, Raivo, 1958-

2009-01-01

Arengufondi nõukogu esimees Raivo Vare kirjutab, et eurotsooni pääsemine on ilus unistus ja hea eesmärk, kuid me peame mõistma, et sellega ei saabu ajaloo lõpp. Tallinna Tehnikaülikooli aulas 25. novembril 2009 toimunud konverentsist "Eesti pärast eurot". Konverentsi lõppdiskussiooni pidasid president Toomas Hendrik Ilves ja briti ajakirja "The Economist" analüütik Edward Lucas

Jagades tulevikku? : uue meedia ja fotohariduse konverents Tartu Kõrgemas Kunstikoolis / Raivo Kelomees

Index Scriptorium Estoniae

Kelomees, Raivo, 1960-

2002-01-01

19. ja 20. IV toimunud konverents "Sharing the Future" oli pühendatud foto ja uue meedia hariduse küsimustele endises Ida-Euroopas. Eestist esinesid Ants Juske ja konverentsi korraldanud Peeter Linnap ning Raivo Kelomees. Briti haridussüsteemist rääkisid Robin Dance ja Paul Rodgers

Why publish with AGU?

Science.gov (United States)

Graedel, T. E.

The most visible activity of the American Geophysical Union is its publication of scientific journals. There are eight of these: Journal of Geophysical Research—Space Physics (JGR I), Journal of Geophysical Research—Solid Earth (JGR II), Journal of Geophysical Research—Oceans and Atmospheres (JGR III), Radio Science (RS), Water Resources Research (WRR), Geophysical Research Letters (GRL), Reviews of Geophysics and Space Physics (RGSP), and the newest, Tectonics.AGU's journals have established solid reputations for scientific excellence over the years. Reputation is not sufficient to sustain a high quality journal, however, since other factors enter into an author's decision on where to publish his or her work. In this article the characteristics of AGU's journals are compared with those of its competitors, with the aim of furnishing guidance to prospective authors and a better understanding of the value of the products to purchasers.

AGU honored for Antarctic book

Science.gov (United States)

AGU has won an honorable mention award at the Fifteenth Annual Awards Program for Excellence in Professional and Scholarly Publishing sponsored by the Association of American Publishers for the book Volcanoes of the Antarctic Plate and Southern Oceans. The book is part of AGU's Antarctic Research Series, an outgrowth of research done during the International Geophysical Year that was begun in 1963 with a grant from the National Science Foundation. The award was presented at the AAP Annual Awards Dinner on February 6 at the Ritz-Carlton Hotel in Washington, D.C. The award consists of a medallion and a plate on which the names of the publisher, title, and authors are engraved.

Ensuring Integrity in AGU Publications and Compliance With Dual Publication Policy

Science.gov (United States)

Kumar, Praveen; Calais, Eric

2011-03-01

To ensure the highest standards for publication, AGU has begun screening manuscript submissions using CrossCheck (http://www.crossref.org/crosscheck.html) for possible verbatim use of previously published material. Water Resources Research and Geophysical Research Letters have tested this technology since summer 2010. It has proven very useful in ensuring the highest integrity in publication standards and compliance with the AGU dual publication policy (http://www.agu.org/pubs/authors/policies/dualpub_policy.shtml). According to Barbara Major, assistant director of journals, other AGU journals will adopt this screening process in the near future.

Puhkus moodsas kalurikülas / Karen Jagodin ; kommenteerinud Indrek Mikk, Raivo Kotov

Index Scriptorium Estoniae

Jagodin, Karen, 1982-

2009-01-01

GoSpa residentsid Kuressaares. Arhitektid: Indrek Mikk, Raivo Kotov (KOKO Arhitektid). Sisearhitekt: Kätlin Ölluk. Projekt: 2007, valmis: 2009. Suvitajatele mõeldud viiest kahekorruselisest hoonest koosnev ansambel on liigendatud mahtude ja lehisepuidust-betoonist fassaadidega. Terrassid ja rõdud avanevad peamiselt suunaga merele. Kortereid saab endale osta või üürida

AGU hydrology publication outlets

Science.gov (United States)

Freeze, R. Allan

In recent months I have been approached on several occasions by members of the hydrology community who asked me which of the various AGU journals and publishing outlets would be most suitable for a particular paper or article that they have prepared.Water Resources Research (WRR) is the primary AGU outlet for research papers in hydrology. It is an interdisciplinary journal that integrates research in the social and natural sciences of water. The editors of WRR invite original contributions in the physical, chemical and biological sciences and also in the social and policy sciences, including economics, systems analysis, sociology, and law. The editor for the physical sciences side of the journal is Donald R. Nielson, LAWR Veihmeyer Hall, University of California Davis, Davis, CA 95616. The editor for the policy sciences side of the journal is Ronald G. Cummings, Department of Economics, University of New Mexico, Albuquerque, NM 87131

Transcriptomic profile of aguR deletion mutant of Lactococcus lactis subsp. cremoris CECT 8666

Science.gov (United States)

del Rio, Beatriz; Linares, Daniel M.; Redruello, Begoña; Martin, Maria Cruz; Fernandez, Maria; de Jong, Anne; Kuipers, Oscar P.; Ladero, Victor; Alvarez, Miguel A.

2015-01-01

Lactococcus lactis subsp. cremoris CECT 8666 (formerly GE2-14) is a dairy strain that catabolizes agmatine (a decarboxylated derivative of arginine) into the biogenic amine putrescine by the agmatine deiminase (AGDI) pathway [1]. The AGDI cluster of L. lactis is composed by five genes aguR, aguB, aguD, aguA and aguC. The last four genes are responsible for the deamination of agmatine to putrescine and are co-transcribed as a single policistronic mRNA forming the catabolic operon aguBDAC[1]. aguR encodes a transmembrane protein that functions as a one-component signal transduction system that senses the agmatine concentration of the medium and accordingly regulates the transcription of aguBDAC[2], which is also transcriptionally regulated by carbon catabolic repression (CCR) via glucose, but not by other sugars such as lactose and galactose [1], [3]. Here we report the transcriptional profiling of the aguR gene deletion mutant (L. lactis subsp. cremoris CECT 8666 ∆aguR) [2] compared to the wild type strain, both grown in M17 medium with galactose as carbon source and supplemented with agmatine. The transcriptional profiling data of AguR-regulated genes were deposited in the Gene Expression Omnibus (GEO) database under accession no. GSE59514. PMID:26697381

Transcriptomic profile of aguR deletion mutant of Lactococcus lactis subsp. cremoris CECT 8666

Directory of Open Access Journals (Sweden)

Beatriz del Rio

2015-12-01

Full Text Available Lactococcus lactis subsp. cremoris CECT 8666 (formerly GE2-14 is a dairy strain that catabolizes agmatine (a decarboxylated derivative of arginine into the biogenic amine putrescine by the agmatine deiminase (AGDI pathway [1]. The AGDI cluster of L. lactis is composed by five genes aguR, aguB, aguD, aguA and aguC. The last four genes are responsible for the deamination of agmatine to putrescine and are co-transcribed as a single policistronic mRNA forming the catabolic operon aguBDAC [1]. aguR encodes a transmembrane protein that functions as a one-component signal transduction system that senses the agmatine concentration of the medium and accordingly regulates the transcription of aguBDAC [2], which is also transcriptionally regulated by carbon catabolic repression (CCR via glucose, but not by other sugars such as lactose and galactose [1,3]. Here we report the transcriptional profiling of the aguR gene deletion mutant (L. lactis subsp. cremoris CECT 8666 ∆aguR [2] compared to the wild type strain, both grown in M17 medium with galactose as carbon source and supplemented with agmatine. The transcriptional profiling data of AguR-regulated genes were deposited in the Gene Expression Omnibus (GEO database under accession no. GSE59514.

'All in the same boat'? Patient and carer attitudes to peer support and social comparison in Motor Neurone Disease (MND).

Science.gov (United States)

Locock, Louise; Brown, Janice B

2010-10-01

This paper explores attitudes to peer support among people with Motor Neurone Disease (MND) and their family carers. It reports findings from a secondary analysis of data from two UK interview studies conducted by the authors. The process of secondary analysis is reported in detail. 48 people with MND and 22 carers were interviewed in 2005-2007. The authors identified narrative extracts on peer support from their own datasets and exchanged them for independent thematic analysis. Subsequent discussion, drawing on literature on support groups and social comparison, led to an exploration of two overarching themes: valuing camaraderie and comparison, and choosing isolation. Findings suggest that social comparison theory is a useful framework for analysing attitudes to MND support groups, but that on its own it is insufficient. 'Valuing camaraderie and comparison' explains how support groups offer practical and social support, as well as beneficial opportunities for social comparison. Seeing others coping well with the condition can provide hope, while downward comparison with those worse off can also make people feel better about their own situation. However, most people are also shocked and saddened by seeing others with the condition. Tension of identity can occur when group membership starts to define the individual as 'a person with MND, rather than the person I am that happens to have MND'. Choosing isolation can be a deliberate defensive strategy, to protect oneself from witnessing one's possible future. Levels of involvement may change over time as people struggle with their changing needs and fears. Copyright © 2010 Elsevier Ltd. All rights reserved.

AGU education and public outreach programs: Empowering future Earth and space scientists

Science.gov (United States)

Adamec, Bethany; Asher, Pranoti

2011-10-01

The staff and leadership of AGU are committed to fostering excellence in Earth and space science education. While AGU's Strategic Plan does not specifically highlight primary or secondary education among its objectives, outreach in this area plays a significant role in developing and nurturing the next generation of Earth and space scientists. Several educational goals along with specific strategies will help AGU meet its goal related to workforce or talent pool development. Particular emphasis is being placed on building partnerships and collaborations that will increase the effectiveness of AGU's outreach efforts related to education.

Liikluses huligaanitsemine toob karmi karistuse / Raivo Aeg

Index Scriptorium Estoniae

Aeg, Raivo, 1962-

2007-01-01

Ilmunud ka: Põhjarannik, 22. mai 2007, lk. 2; Severnoje Poberezhje, 22. mai 2007, lk. 2; Oma Saar, 23. mai 2007, lk. 5; Postimees, 23. mai 2007, lk. 16; SL Õhtuleht, 23. mai 2007, lk. 12; Virumaa Teataja, 24. mai 2007, lk. 11; Vooremaa, 24. mai 2007, lk. 2; Koit, 24. mai 2007, lk. 6; Lõunaleht, 24. mai 2007, lk. 2; Võrumaa Teataja, 24. mai 2007, lk. 2; Den za Dnjom, 25. mai 2007, lk. 19; Harjumaa, 25. mai 2007, lk. 2; Vali Uudised, 25. mai 2007, lk. 2; Lääne Elu, 26. mai 2007, lk. 4; Järva Teataja, 29. mai 2007, lk. 2; Narvskaja Nedelja, 2. juuni 2007, lk. 4. Politseiameti peadirektor Raivo Aeg liiklusjärelevalve tõhustamisest, liikluskeskkonna ohutumaks muutmisest

Fostering Diversity in the Earth and Space Sciences: The Role of AGU

Science.gov (United States)

Snow, J. T.; Johnson, R. M.; Hall, F. R.

2002-12-01

In May 2002, AGU's Committee on Education and Human Resources (CEHR) approved a new Diversity Plan, developed in collaboration with the CEHR Subcommittee on Diversity. Efforts to develop a diversity plan for AGU were motivated by the recognition that the present Earth and space science community poorly represents the true diversity of our society. Failure to recruit a diverse scientific workforce in an era of rapidly shifting demographics could have severe impact on the health of our profession. The traditional base of Earth and space scientists in the US (white males) has been shrinking during the past two decades, but women, racial and ethnic minorities, and persons with disabilities are not compensating for this loss. The potential ramifications of this situation - for investigators seeking to fill classes and recruit graduate students, for institutions looking to replace faculty and researchers, and for the larger community seeking continued public support of research funding - could be crippling. AGU's new Diversity Plan proposes a long-term strategy for addressing the lack of diversity in the Earth and space sciences with the ultimate vision of reflecting diversity in all of AGU's activities and programs. Four key goals have been identified: 1) Educate and involve the AGU membership in diversity issues; 2) Enhance and foster the participation of Earth and space scientists, educators and students from underrepresented groups in AGU activities; 3) Increase the visibility of the Earth and space sciences and foster awareness of career opportunities in these fields for underrepresented populations; and 4) Promote changes in the academic culture that both remove barriers and disincentives for increasing diversity in the student and faculty populations and reward member faculty wishing to pursue these goals. A detailed implementation plan that utilizes all of AGU's resources is currently under development in CEHR. Supportive participation by AGU members and

Major Changes in AGU Publication Fees

Science.gov (United States)

Cook, Bill

2010-12-01

Effective with any manuscript submitted after 31 December 2010, AGU is eliminating color charges in all formats. At the same time that we eliminate color charges, we are simplifying publication fees. Articles published in Journal of Geophysical Research; Geochemistry, Geophysics, Geosystems; and Radio Science will each have a flat fee of $1000, and Geophysical Research Letters (GRL) articles will each have a flat fee of $500. These prices represent a small drop from the average cost currently paid by authors. We will retain the excess page charges for full articles longer than 13 pages (including Water Resources Research) and 4 pages for letters, comments, and replies. This simplification means we can streamline the “calculator” authors must use when submitting manuscripts to AGU.

Regulation of the alpha-glucuronidase-encoding gene ( aguA) from Aspergillus niger.

Science.gov (United States)

de Vries, R P; van de Vondervoort, P J I; Hendriks, L; van de Belt, M; Visser, J

2002-09-01

The alpha-glucuronidase gene aguA from Aspergillus niger was cloned and characterised. Analysis of the promoter region of aguA revealed the presence of four putative binding sites for the major carbon catabolite repressor protein CREA and one putative binding site for the transcriptional activator XLNR. In addition, a sequence motif was detected which differed only in the last nucleotide from the XLNR consensus site. A construct in which part of the aguA coding region was deleted still resulted in production of a stable mRNA upon transformation of A. niger. The putative XLNR binding sites and two of the putative CREA binding sites were mutated individually in this construct and the effects on expression were examined in A. niger transformants. Northern analysis of the transformants revealed that the consensus XLNR site is not actually functional in the aguA promoter, whereas the sequence that diverges from the consensus at a single position is functional. This indicates that XLNR is also able to bind to the sequence GGCTAG, and the XLNR binding site consensus should therefore be changed to GGCTAR. Both CREA sites are functional, indicating that CREA has a strong influence on aguA expression. A detailed expression analysis of aguA in four genetic backgrounds revealed a second regulatory system involved in activation of aguA gene expression. This system responds to the presence of glucuronic and galacturonic acids, and is not dependent on XLNR.

The Submillimeter Spectrum of MnH and MnD (X7Σ+)

Science.gov (United States)

Halfen, D. T.; Ziurys, L. M.

2008-01-01

The submillimeter-wave spectrum of the MnH and MnD radicals in their 7Σ+ ground states has been measured in the laboratory using direct absorption techniques. These species were created in the gas phase by the reaction of manganese vapor, produced in a Broida-type oven, with either H2 or D2 gas in the presence of a DC discharge. The N = 0 → 1 transition of MnH near 339 GHz was recorded, which consisted of multiple hyperfine components arising from both the manganese and hydrogen nuclear spins. The N = 2 → 3 transition of MnD near 517 GHz was measured as well, but in this case only the manganese hyperfine interactions were resolved. Both data sets were analyzed with a Hund's case b Hamiltonian, and rotational, fine structure, magnetic hyperfine, and electric quadrupole constants have been determined for the two manganese species. An examination of the magnetic hyperfine constants shows that MnH is primarily an ionic species, but has more covalent character than MnF. MnH is a good candidate species for astronomical searches with Herschel, particularly toward material associated with luminous blue variable stars.

Characterizations of microstructural evolutions to heating of two 16MND5 alloys

International Nuclear Information System (INIS)

Vereecke, B.

2003-01-01

The aim of this work is to predict the risks of ruin of power plants from scenario of accidents. For that, we have to know and simulate the behaviour of material at high temperatures (600-1300 C) or more exactly, of materials of analogous composition but of different sources, constituting the vessel of a PWR reactor in 16MND5 steel. Previous studies (Vereecke and al CFM2003) have shown that the vessel steels can present in the temperature range 900-1000 C an important variability of creep behaviour and in particular of damages mechanisms (ductile or intergranular) which can radically change from a steel to another. In order to explain and model the sources of different damages, we have carried out a metallurgical study on two steels of 16MND5 type. For different kinetics of heating, have been studied: the hardnesses, the grain sizes and the thermo-electric power (TEP). This last qualitative physical measurement allows to follow in our case the dissolution of the alloy elements having precipitated, phenomenon which could be at the origin of the differences of the damage mechanisms noticed at high temperature. (O.M.)

Videokunst pärast videokunsti : Pärnu filmi- ja videofestival detsembris 2009 / Raivo Kelomees

Index Scriptorium Estoniae

Kelomees, Raivo, 1960-

2010-01-01

15. Pärnu filmi- ja videofestival 2009 Port Artur 2 kaubanduskeskuses. Esitatud tööde autorid loetletud. 5. 12. 2009 toimunud rahvusvahelisest konverentsist "Videokunst pärast videokunsti", kus arutleti video nüüdisaegse olukorra üle. Al Paldroki, Raivo Kelomehe, Teijo Pellineni (Soome), Chris Halesi (Inglismaa), Indrek Grigori, Silja Saarepuu ja Hans-Gunter Locki mõtteavaldustest

Exploration Station Brings AGU Science to Children and Parents

Science.gov (United States)

Cooper, Paul

2008-08-01

More than 20 families from the Fort Lauderdale, Fla., area attended AGU's pilot family science event, ``Exploration Station,'' held on 26 May as part of the 2008 Joint Assembly. During the event-which was organized by AGU's education staff, the Association for Astronomy Education, and the Solar Physics Division of the American Astronomical Association-children and parents had the opportunity to discuss science with researchers and to get involved with many hands-on activities.

Eesti mehed panid maja rääkima / Raivo Raestik, Priit Vimberg ; interv. Einar Ellermaa

Index Scriptorium Estoniae

Raestik, Raivo

2008-01-01

Firma Yoga Intelligence poolt välja töötatud kinnisvara haldussüsteemi lahendusest, kus majade kütet, ventilatsiooni, mõõdikute kauglugemist, elektri-, turva- ja läbipääsusüsteeme juhitakse ühe süsteemiga. Küsimustele vastavad Raivo Raestik ja Priit Vimberg

AGU Webinars: Leveraging 21st Century Technology to Level the Playing Field

Science.gov (United States)

Janick, N. G.; Harwell, D. E.; Hankin, E. R.; Asher, P. M.; Marasco, L.

2017-12-01

AGU Webinars offer weekly insights into topics in the Earth and space sciences presented by scientists and other experts every Thursday at 2:00 pm ET. Its monthly Professional Development series emphasizes essential soft skills, connections to experiential and learning opportunities, jobs outside of academia, and other career resources. Additional topics focus on science communication, science policy, special topics for Earth and space science department heads and chairs, technical highlights from AGU Meetings and Publications, among others. By offering these live sessions and recordings free of charge to all participants, AGU is removing barriers to entry and encouraging diversity in the global talent pool of Earth and space scientists. This presentation will look at the first year of the AGU Webinars program and explore its future goals and how we can achieve them together.

Science policy events at the 2012 AGU Fall Meeting

Science.gov (United States)

Hankin, Erik

2012-10-01

Are you interested in the intersection of science and policy, looking to make an impact on Capitol Hill, or concerned about the increasing number of attacks against scientists and their academic freedom? AGU Public Affairs offers many events at the 2012 Fall Meeting to assist member involvement in political processes and inform scientists of their rights and options should their research come under legal fire. Learn how you can share your science with policy makers to help inform policy at two luncheon events at the Fall Meeting. If you have ever considered working as a science expert for a member of Congress or reporting science in a mass media outlet, then you should attend the first luncheon, How to be a Congressional Science Fellow or Mass Media Fellow. The event will feature current AGU Congressional Science Fellows detailing their experiences working in Congress as well as past AGU Mass Media Fellows sharing their stories of reporting for a news organization. The luncheon will be held on Tuesday, 4 December, from 12:30 to 1:30 P.M. at the Marriott Hotel, in room Golden Gate B. In addition, current and former fellows will be available for one-on-one interactions at the AGU Marketplace from 3:30 to 4:30 P.M. on Tuesday, 4 December, through Thursday, 6 December.

AGU Pathfinder: Career and Professional Development Resources for Earth and Space Scientists

Science.gov (United States)

Harwell, D. E.; Asher, P. M.; Hankin, E. R.; Janick, N. G.; Marasco, L.

2017-12-01

The American Geophysical Union (AGU) is committed to inspiring and educating present and future generations of diverse, innovative, and creative Earth and space scientists. To meet our commitment, AGU provides career and educational resources, webinars, mentoring, and support for students and professionals at each level of development to reduce barriers to achievement and to promote professional advancement. AGU is also working with other organizations and educational institutions to collaborate on projects benefiting the greater geoscience community. The presentation will include an overview of current Pathfinder efforts, collaborative efforts, and an appeal for additional partnerships.

Lanzerotti to Head New AGU Journal on Space Weather

Science.gov (United States)

Lifland, Jonathan

Louis J. Lanzerotti has been named editor of a new AGU online publication devoted to the emerging field of near-Earth space conditions and their effects on technical systems. Space Weather: The International Journal of Research and Applications, will be the first journal dedicated solely to the subject, and will include peer-reviewed research, as well as news, features, and opinion articles. A quarterly magazine digest will also be published from the online edition and distributed free of charge to space weather professionals. Lanzerotti, a longtime AGU member who was elected an AGU Fellow in 1985, is currently a consulting physicist at Lucent Technologies Bell Laboratories, and a distinguished research professor at the New Jersey Institute of Technology. He also serves on the governing board of the American Institute of Physics. He is author or co-author of more than 500 publications, including many related to space weather and its effects on communications.

Kontorihoone : Järvevana tee 9g, Tallinn = Office Building : 9g Järvevana Str., Tallinn / Raivo Puusepp

Index Scriptorium Estoniae

Puusepp, Raivo

2003-01-01

Merko Ehituse 6-korruseline suletud kabinetsüsteemis büroohoone. Arhitekt Raivo Puusepp, kaasa töötasid Maike Heido ja Peeter Loo. Sisekujundaja Kaire Kemp (ArtAku). Konstruktiivne lahendus: Neoprojekt. Projekt 2001, valmis 2003. I korruse plaan, sise- ja 2 välisvaadet

Regulation of the alpha-glucuronidase-encoding gene (aguA) from Aspergillus niger

NARCIS (Netherlands)

Vries, de R.P.; Vondervoort, van de P.J.I.; Hendriks, L.; Belt, van de M.; Visser, J.

2002-01-01

The !-glucuronidase gene aguA from Aspergillus niger was cloned and characterised. Analysis of the promoter region of aguA revealed the presence of four putative binding sites for the major carbon catabolite repressor protein CREA and one putative binding site for the transcriptional activator XLNR.

Brittle and ductile rupture of 16MND5 steel. Irradiation effect

International Nuclear Information System (INIS)

Al Mundheri, M.; Soulat, P.; Pineau, A.

1986-06-01

Toughness tests have been made on 16MND5 steel (A508Cl3 steel) - before and after irradiation at 290 0 C (3.10 19 n/cm 2 , E > 1 MeV). It is shown that toughness is lowered following the irradiation and that it is a decreasing function of the thickness of the test pieces. In parallel, tests on three geometries of entailed specimens, prepared in the non-irradiated material, have been made at different temperatures to apply the methodology of local approach of ductile-brittle rupture [fr

Common interests bind AGU and geophysical groups around the globe

Science.gov (United States)

McEntee, Christine

2012-02-01

In continuation of our work to strengthen alliances with key organizations in the Earth and space science community, AGU president Michael McPhaden, president-elect Carol Finn, and I held a series of meetings with leaders from other science societies during the 2011 Fall Meeting. Over the course of 2 days we met with leaders from the Geophysical Society of America, European Geosciences Union, Japan Geosciences Union, Ethiopian Geophysical Union, Asia Oceania Geosciences Society, Chinese Geophysical Society, and Asociación Latinoamericana de Geofísica Espacial. This gave us a valued opportunity to discuss the common interests and challenges we all face and to learn from each other's experience. The meetings allowed AGU to strengthen existing cooperative agreements and reach new levels of understanding between us and other societies. Additionally, we met with representatives from the Korean Ocean Research and Development Institute to discuss their intention to establish a geophysical union modeled after AGU.

Microstructural influence on the local behaviour of 16MND5 steel

International Nuclear Information System (INIS)

Sekfali, S.

2004-06-01

16MND5 Steel or A508 Cl3 is used for manufacture by forging of nuclear reactor vessels. This material presents a good compromise in term of tenacity and yield stress, its microstructure is mainly bainitic tempered. Because of the chemical composition local variation and process of development, this material presents microstructural heterogeneities which can locally modify the properties of damage. In particular, some zones present a martensitic microstructure. The goal of this thesis is to bring some explanations on the influence of the microstructure; more particularly, size of the crystallographic entities and their spatial distribution on the local behaviour of 16MND5 steel. Two microstructures were elaborated for this purpose, a tempered bainitic microstructure and a tempered martensitic microstructure. An experimental characterization was carried out on the two microstructures in order to determine morphology, spatial distribution of the crystallographic orientations and tensile behaviour. A deposit of micro grid was carried out on tensile specimens to determine the experimental deformation field on a beforehand EBSD analyzed zone. The determination of the tensile behaviour allowed the identification of a multi crystalline behaviour law by a reverse method using the density of dislocation on each system of slip. This behaviour law was used in simulations with a finite element method to simulate the local mechanical field of the two microstructures and to compare with the obtained experimental deformation fields. It results, a good adequacy between simulations and experiments and the description of the influence of the neighbor grain's orientation on the local behaviour. (author)

Guidelines in motor neurone disease (MND)/amyotrophic lateral sclerosis (ALS)--from diagnosis to patient care.

Science.gov (United States)

Mitchell, J D

2000-12-01

This paper reviews the scope of current guidelines in motor neurone disease (MND)/amyotrophic lateral sclerosis (ALS) and examines issues which have arisen in the preparation of these documents. The review concludes with an evaluation of the impact of the guidelines which have been produced to date and looks towards potential future developments in this area.

Guidelines in motor neurone disease (MND)/amyotrophic lateral sclerosis (ALS) - from diagnosis to patient care.

Science.gov (United States)

Mitchell, J D

2000-12-01

This paper reviews the scope of current guidelines in motor neurone disease (MND)/amyotrophic lateral sclerosis (ALS) and examines issues which have arisen in the preparation of these documents. The review concludes with an evaluation of the impact of the guidelines which have been produced to date and looks towards potential future developments in this area.

Assessing the efficacy of advancing underrepresented minority groups through AGU's Student Programs

Science.gov (United States)

Marasco, L.; Hurtado, C.; Gottschall, H.; Meisenhelder, K.; Hankin, E. R.; Harwell, D. E.

2017-12-01

The American Geophysical Union (AGU) strives to cultivate a diverse and inclusive organization that uses its position to build the global talent pool in Earth and space science. To cultivate a diverse talent pool, AGU must also foster a diverse student member population. The two largest AGU programs serving students are the Outstanding Student Paper Award (OSPA) and the Student Grants programs. OSPA allows students to practice their presentation skills and receive valuable feedback from experienced scientists. Over 3,000 students participated in OSPA at Fall Meeting 2016. The Student Grants program includes a suite of 14 travel and research grant opportunities. Over 2,000 students applied for grant opportunities in 2016 and 246 grants and fellowships were awarded. The OSPA and Student Grants programs also engage non-student members through volunteering opportunities for program roles, such as OSPA judge or grant reviewer. This presentation will look at the temporal participation trends of underrepresented minority groups in AGU's OSPA and Student Grants programs. The participation of underrepresented minority groups will also be compared before and after the implementation of policy changes to the Student Grants program in 2012.

AguR, a Transmembrane Transcription Activator of the Putrescine Biosynthesis Operon in Lactococcus lactis, Acts in Response to the Agmatine Concentration.

Science.gov (United States)

Linares, Daniel M; Del Rio, Beatriz; Redruello, Begoña; Ladero, Victor; Martin, M Cruz; de Jong, Anne; Kuipers, Oscar P; Fernandez, Maria; Alvarez, Miguel A

2015-09-01

Dairy industry fermentative processes mostly use Lactococcus lactis as a starter. However, some dairy L. lactis strains produce putrescine, a biogenic amine that raises food safety and spoilage concerns, via the agmatine deiminase (AGDI) pathway. The enzymatic activities responsible for putrescine biosynthesis in this bacterium are encoded by the AGDI gene cluster. The role of the catabolic genes aguB, aguD, aguA, and aguC has been studied, but knowledge regarding the role of aguR (the first gene in the cluster) remains limited. In the present work, aguR was found to be a very low level constitutively expressed gene that is essential for putrescine biosynthesis and is transcribed independently of the polycistronic mRNA encoding the catabolic genes (aguBDAC). In response to agmatine, AguR acts as a transcriptional activator of the aguB promoter (PaguB), which drives the transcription of the aguBDAC operon. Inverted sequences required for PaguB activity were identified by deletion analysis. Further work indicated that AguR is a transmembrane protein which might function as a one-component signal transduction system that senses the agmatine concentration of the medium and, accordingly, regulates the transcription of the aguBDAC operon through a C-terminal cytoplasmic DNA-binding domain typically found in LuxR-like proteins. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Diffusion-bonded 16MND5-Inconel 690-316LN junction: elaboration and process residual stresses modeling

International Nuclear Information System (INIS)

Martinez, Michael

1999-01-01

The objective of this research thesis is, on the one hand, to elaborate and to characterise a bonded junction of 16MND5 and 316LN steels, and, on the other hand, to develop a simulation tool for the prediction of microstructures after bonding, as well as residual stresses related to this process. The author first reports the study of the use of diffusion bonding by hot isostatic pressing (HIP diffusion bonding) for the bonding of 16MND5 (steel used in French PWR vessel) and 316LN (austenitic stainless steel used in piping), in order to obtain junctions adapted to a use within PWRs. In this case, the use of an Inconel insert material appeared to be necessary to avoid stainless steel carburization. Thus, inserts in Inconel 600 and 690 have been tested. The objective has then been to develop a realistic calculation of residual stresses in this assembly. These stresses are stimulated by quenching. The author notably studied the simulation of temperature dependent phase transformations, and stress induced phase transformations. An existing model is validated and applied to HIP and quenching cycles. The last part reports the calculation of residual stresses by simulation of the mechanical response of the three-component material cooled from 900 C to room temperature and thus submitted to a loading of thermal origin (dilatation) and metallurgical origin (phase transformations in the 16MND5). The effect of carbon diffusion on mechanical properties has also been taken into account. The author discusses problems faced by existing models, and explains the choice of conventional macro-mechanical models. The three materials are supposed to have a plastic-viscoplastic behaviour with isotropic and kinematic strain hardening, and this behaviour is identified between 20 and 900 C [fr

Growing and Supporting the Student and Early Career Pipeline in Earth and Space Sciences - A Spotlight on New AGU Initiatives

Science.gov (United States)

Hankin, E. R.; Williams, B. M.; Asher, P. M.; Furukawa, H.; Holm Adamec, B.; Lee, M.; Cooper, P.

2015-12-01

The American Geophysical Union (AGU) is home to more than 60,000 scientists from 139 countries. Included in this membership are approximately 20,000 (34%) student and early career members. Many well-established programs within AGU provide a dynamic forum for Earth and Space scientists to advance research, collaborate across disciplines, and communicate the importance and impact of science to society regardless of career stage—programs such as AGU publications, scientific meetings and conferences, honors and recognition, and other educational and scientific forums. Additionally, many AGU program initiatives focusing specifically on supporting student and early career scientists and the global talent pool pipeline ones are actively underway. These include both new and long-standing programs. This presentation will describe (1) the overall demographics and needs in Earth and Space sciences, and (2) AGU's coordinated series of programs designed to help attract, retain and support student and early career scientists—with an emphasis on new programmatic activities and initiatives targeting improved diversity. Included in this presentation are a description of the AGU BrightSTaRS Program, the AGU Berkner Program for international students, a newly established AGU Student & Early Career Conference, the AGU Virtual Poster Showcase initiative, the AGU Meeting Mentor program, and GeoLEAD—an umbrella program being jointly built by a coalition of societies to help address Earth and space sciences talent pool needs.

AGU Committee on Education and Human Resources Sub-Committee on Diversity Program for the term 2004-2006

Science.gov (United States)

Alexander, C. J.; Hiza, M.; Jenkins, G.; Karsten, J.; Molina, L.; Pyrtle, A.; Runyon, C.

2004-12-01

The American Geophysical Union (AGU) founded the Diversity Subcommittee in 2000 to address what the AGU felt were important issues for the future of the geoscience community. A recent AGU statement of commitment and concern about issues of diversity reads, in part: It is essential that new strategies for educating, recruiting, and retaining geoscientists from currently under-represented populations be developed (a) for individual investigators seeking students to fill classes or work in their research programs; (b) for institutions looking to replace faculty and researchers; (c) for the larger community looking to the public for continued research funding, and (d) for the future US membership of AGU. In an effort to fulfill its charge, the majority of the 2004-2006 sub-committee's activities will be directed towards: (1) Education of the AGU Membership, including the sub-committee itself, on the salient issues of Diversity; (2) Mentoring and supporting minority students in the pipeline of Earth and Space Science education as well as minority faculty seeking to establish successful collaborations; (3) Establishing a mechanism for quantitative assessment of (a) the AGU demographics, (b) member knowledge, and (c) success of programs in the area of Diversity; (4) Conducting the first ever Chapman Conference on the needs of investigators with disabilities (July, 2005); (5) Partnering with other agencies and societies to build bridges; (6) Creating mechanisms for marketing the Earth and Space sciences to minority audiences; (7) Nurturing of minority members already in the AGU; promoting these members for honors and awards within AGU. Details, goals, and milestones of this program will be presented.

Withdrawal of ventilation at the patient's request in MND: a retrospective exploration of the ethical and legal issues that have arisen for doctors in the UK.

Science.gov (United States)

Phelps, Kay; Regen, Emma; Oliver, David; McDermott, Chris; Faull, Christina

2017-06-01

Ventilatory support has benefits including prolonging survival for respiratory failure in motor neurone disease (MND). At some point some patients may wish to stop the intervention. The National Institute of Health and Care Excellence (NICE) guidance recommends research is needed on ventilation withdrawal. There is little literature focusing on the issues doctors encounter when withdrawing ventilation at the request of a patient. To identify and explore with doctors the ethical and legal issues that they had encountered in the withdrawal of ventilation at the request of a patient with MND. A retrospective thematic analysis of interviews of 24 doctors (including palliative care, respiratory, neurology and general practice) regarding their experiences with withdrawal of ventilation support from patients with MND. Respondents found withdrawal of ventilation at the request of patients with MND to pose legal, ethical and moral challenges in five themes: ethical and legal rights to withdrawal from treatment; discussions with family; discussions with colleagues; experiences of legal advice; issues contributing to ethical complexity. Though clear about the legality of withdrawal of treatment in theory, the practice led to ethical and moral uncertainty and mixed feelings. Many respondents had experienced negative reactions from other healthcare professionals when these colleagues were unclear of the distinction between palliation of symptoms, withdrawal of treatment and assisted death. Legal, ethical and practical guidance is needed for professionals who support a patient with MND who wishes to withdraw from ventilation. Open discussion of the ethical challenges is needed as well as education and support for professionals. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Transcriptomic profile of aguR deletion mutant of Lactococcus lactis subsp. cremoris CECT 8666

NARCIS (Netherlands)

Del Rio, Beatriz; Linares, Daniel M; Redruello, Begoña; Martin, Maria Cruz; Fernandez, Maria; de Jong, Anne; Kuipers, Oscar P; Ladero, Victor; Alvarez, Miguel A

2015-01-01

Lactococcus lactis subsp. cremoris CECT 8666 (formerly GE2-14) is a dairy strain that catabolizes agmatine (a decarboxylated derivative of arginine) into the biogenic amine putrescine by the agmatine deiminase (AGDI) pathway [1]. The AGDI cluster of L. lactis is composed by five genes aguR, aguB,

AGU, Science and Engagement with the Energy Industry

Science.gov (United States)

Leinen, M.; Davidson, E. A.

2016-12-01

The relationship between science and society evolves over time and the social, political, and economic factors shaping this relationship are complex. When problems facing society become more challenging, the public, NGOs, and policy makers call for science to more directly inform solutions, to assure accountability for the use of funds and to address conflicts of interest. But when policy solutions for such challenges require significant economic and societal tradeoffs, discussion of the science can become polarized and politicized. When this occurs, AGU's policies that uphold the highest standards of scientific integrity, address conflicts of interests and promote independence for members are even more important. These policies are implemented through processes for: a) control of science presented at meeting and in publications; b) requirements for data cited in publications to be publicly accessible, and c) an organizational support policy that prohibits sponsors from influencing science presented in AGU programs. The private sector wields vast influence on human behavior and governmental policy through commerce and lobbying. These actions can be controversial when the profit motive appears incongruent with other societal opinions of what is in the public interest. Climate change is an example of this tension, where the economic exploitation of fossil fuels has complex effects on food and energy security as well as on the environment. Nonetheless, the AGU Board unanimously agreed that given our mission to advance science to create a more sustainable earth, engagement of the private sector rather than disengagement is the best way to influence decision makers on all sides because we believe that the private sector needs to be part of any solutions. We plan to use our convening power and scientific authority to bring together diverse views on climate change solutions from the private, NGO, policy, decision-maker and scientific sectors to begin a substantial

The AGU Data Management Maturity Model Initiative

Science.gov (United States)

Bates, J. J.

2015-12-01

In September 2014, the AGU Board of Directors approved two initiatives to help the Earth and space sciences community address the growing challenges accompanying the increasing size and complexity of data. These initiatives are: 1) Data Science Credentialing: development of a continuing education and professional certification program to help scientists in their careers and to meet growing responsibilities and requirements around data science; and 2) Data Management Maturity (DMM) Model: development and implementation of a data management maturity model to assess process maturity against best practices, and to identify opportunities in organizational data management processes. Each of these has been organized within AGU as an Editorial Board and both Boards have held kick off meetings. The DMM model Editorial Board will recommend strategies for adapting and deploying a DMM model to the Earth and space sciences create guidance documents to assist in its implementation, and provide input on a pilot appraisal process. This presentation will provide an overview of progress to date in the DMM model Editorial Board and plans for work to be done over the upcoming year.

Bridging Science and Policy: The AGU Science Policy Conference

Science.gov (United States)

Hankin, E. R.; Uhlenbrock, K.; Landau, E. A.

2013-12-01

In recent years, science has become inextricably linked to the political process. As such, it is more important now than ever for science to forge a better relationship with politics, for the health of both science and society. To help meet this need, the American Geophysical Union (AGU) strives to engage its members, shape policy, and inform society about the excitement of Earth and space science and its role in developing solutions for the sustainability of the planet. In June 2013, AGU held its second annual Science Policy Conference in Washington, D.C. The goal of the conference is to provide a new forum for diverse discussions and viewpoints on the challenges and opportunities of science policy, with a focus on applications of Earth and space science that serve local, national, and international communities. The meeting brought together more than 300 scientists, policy makers, industry professionals, members of the press, and other stakeholders to discuss the topics concerning the Arctic, climate change, oceans, energy, technology and infrastructure, and natural hazards science as they relate to challenges impacting society. Sessions such as 'The Water-Energy Nexus,' 'Potential for Megadisasters,' 'The Changing Ocean and Impacts on Human Health,' and 'Drowning and Drought: Agricultural Impacts of Climate Change' are examples of some of the intriguing and timely science policy issues addressed at the conference. The findings from the conference were used to develop a summary report. The report highlights key facts and figures to be used as a resource in discussions with policy makers and other stakeholders regarding the conference topics. This presentation will discuss the goals and outcomes of the conference and how the event represents one of the many ways AGU is approaching its 'Science and Society' priority objective as part of the Union's strategic plan; namely by increasing the effectiveness and recognition of AGU among policy makers as an authoritative

Growing our capacity within AGU to better connect and engage with new and novel partners

Science.gov (United States)

Vano, J. A.

2017-12-01

It is easy to give talks at AGU about the value of science. It is much harder, yet critical, to share the value of science with non-scientists. Yet through conversations and ultimately through partnerships with the communities and decision makers the science aims to serve, the value of the science can be elevated and research transformed to be more actionable. Throughout AGU, there is a growing recognition that we can do this better. This growing movement comes from all corners of the Union, as evidenced by increasing abstracts on the topic, and is bringing to light efforts with a common thread of researchers collaborating with practitioners to design, conduct, apply, and share research in ways that connect more closely to society's needs. This year, a team of AGU members came together to plan a series of Science to Action sessions, workshops, networking events, and more (see http://thrivingearthexchange.org/fall-meeting-2017 for updates). This presentation will provide an overview of these Science to Action activities, how they connect with current AGU resources, and, based on past discussions and a survey of participants, what future directions and resources would provide the biggest benefits to continue to improve AGU's capacity to foster more effective partnerships. Audience participation on ideas for future directions will be encouraged.

Improving Diversity and Educational Outreach at the K-14 level: A Call to Action for the AGU Membership

Science.gov (United States)

Hall, F. R.; Johnson, R.

2002-12-01

In 2002, the Subcommittee on Diversity (SD) of the Committee on Education and Human Resources (CEHR) submitted a Diversity Plan to the leadership of AGU. This plan outlines specific programs and goals that AGU can follow to help improve diversity in the Earth and space sciences. Diversity issues are key components to improve the human resource potential in the geosciences. As women are the majority population, and racial and ethnic minorities are experiencing the largest growing segment of the United States population, it is within our best interest to actively recruit and retain these populations into our dynamic fields of study. The SD recognizes that the strength of the AGU lies within its membership. Composed of some of the brightest and talented scientists in the world, the AGU members are leaders and pioneers in our understanding of the Earth System. Yet, many, if not most, people within underrepresented communities are not aware of the relevance that the Earth and space sciences play in their lives. In this discussion, we will discuss the importance of the AGU membership in the Diversity Plan. In addition, we will outline specific things that AGU members can do to improve access of US students and citizenry to Earth and space science education. These steps require that AGU members become active advocates in the public, especially at the K-14 level.

Scientific Integrity and Professional Ethics at AGU - The Establishment and Evolution of an Ethics Program at a Large Scientific Society

Science.gov (United States)

McPhaden, Michael; Leinen, Margaret; McEntee, Christine; Townsend, Randy; Williams, Billy

2016-04-01

The American Geophysical Union, a scientific society of 62,000 members worldwide, has established a set of scientific integrity and professional ethics guidelines for the actions of its members, for the governance of the union in its internal activities, and for the operations and participation in its publications and scientific meetings. This presentation will provide an overview of the Ethics program at AGU, highlighting the reasons for its establishment, the process of dealing ethical breaches, the number and types of cases considered, how AGU helps educate its members on Ethics issues, and the rapidly evolving efforts at AGU to address issues related to the emerging field of GeoEthics. The presentation will also cover the most recent AGU Ethics program focus on the role for AGU and other scientific societies in addressing sexual harassment, and AGU's work to provide additional program strength in this area.

AGU candidates for office, 1998”2000, Union officers

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Marcia K. McNutt. AGU member since 1976, Director of the Monterey Bay Aquarium Research Institute. Major areas of interest are lithospheric tectonics and mantle geodynamics. B.A. in physics (Phi Beta Kappa, summa cum laude), 1973, Colorado College; Ph.D. in Earth science, 1978, Scripps Institution of Oceanography. Researcher at U.S. Geological Survey, Menlo Park, 1979-1982semi Professor at Massachusetts Institute of Technology, 1982-1997. Member of American Association for the Advancement of Science. Authored 74 publications, 45 in AGU journals. Most important publications include The Superswell and mantle dynamics beneath the South Pacific, Science, 248, 969-975,1990semi Marine geodynamics: depth-age revisited, Rev. Geophys., U.S. National Report Supplement, 413-418,1995 Mapping the descent of Indian and Eurasian plates beneath the Tibetan plateau from gravity anomalies, J. Geophys. plume theory to explain multiple episodes of stress-triggered volcanism in the Austral Islands, Nature, in press, 1997. Awarded Macelwane Medal, 1988; Doctor of Science (honoris causa), Colorado College, 1988; NSF Visiting Professorship for Women, Lamont-Doherty Earth Observatory, 1989-1990semi Griswold Professor of Geophysics, MIT, 1991-1997 Outstanding Alumni Award, The Blake Schools, Minneapolis, 1993; Capital Science Lecturer, Carnegie Institution, 1995; Phi Beta Kappa Visiting Scholar, 1996-1997 MIT School of Science Graduate Teaching Prize, 1996. AGU service as Associate Editor and Guest Editor of Journal of Geophysical Research-Solid Earth, member of Program, Budget and Finance, and Audit and Legal Affairs committeessemi; chair of Publications and Macelwane committees, and President of the Tectonophysics Section.

AGU Cinema: Festival of short science films at Fall Meeting

Science.gov (United States)

Harned, Douglas A.

2012-11-01

New technologies have revolutionized the use of video as a means of science communication and have made it easier to create, distribute, and view. With video having become omnipresent in our culture, it sometime supplements or even replaces writing in many science and education applications. An inaugural science film festival sponsored by AGU at the 2012 Fall Meeting in San Francisco, Calif., in December will showcase short videos—30 minutes or less in length—developed to disseminate scientific results to various audiences and to enhance learning in the classroom. AGU Cinema will feature professionally produced, big budget films alongside low-budget videos aimed at niche audiences and made by amateurs. The latter category includes videos made by governmental agency scientists, educators, communications specialists within scientific organizations, and Fall Meeting oral and poster presenters.

Why AGU is important in Eastern Europe and should increase its role even more?

Science.gov (United States)

Mocanu, V.

2007-12-01

After the fall of the ex-communist system about twenty years ago, the East European countries faced a significant, multilateral challenge in all aspects of their economical, financial, military, scientific and especially educational and professional life. They had a pretty robust tradition in classic education and research, but had to prepare their young generation and specialists for a hard competition for grad-, post grad- and professional level competing with colleagues from other parts of the world. They had to restructure their systems and re-discovered the professional societies. AGU represented a certain model of efficiency on handling various aspects of geoscientific activities: integration of geophysics with other related disciplines like atmospheric sciences, hydrology and hydrogeology, volcanism, geochemistry etc., from deep Earth to the intergalactic space. Close cooperation with other boundary sciences, regular and very well organized meetings dedicated more to Solid earth (AGU Fall Meeting) or Near-Surface Geophysics (AGU Spring Meetings), its very close cooperation with the sister societies from Europe, other North, Central and South American countries as well as the Far East and Australia, permanent opening towards a strong international cooperation with all countries and societies world- wide, very active interest in education and career orientation, strong publication policy represented a certain attraction and a very tempting model for the East European countries. Their very quick development has to be joined by transformation of their higher education and research system in such a way that they become more and more competitive with other countries worldwide. They have to develop their own system so that it attracts more and more youngsters to remain/return home and contribute to the advance of their home countries and, in close partnerships with other developed and developing countries, with the guidance of the professional societies like AGU

Advancing diversity and inclusion through AGU's mentoring programs

Science.gov (United States)

Asher, P. M.; Marasco, L.; Hurtado, C.; Hanlon, S. M.; Ambrogio, O.

2017-12-01

AGU offers three separate mentoring programs at the Fall Meeting. These are the Undergraduate Mentoring Program, Career and Research Advice Mentorship (CRAM) sessions, and the Sharing Science mentoring program. While each of these have had an impact on students and mentors, these programs are limited in that the mentor and mentee interactions only occur during the Fall Meeting. To increase the impact of mentoring beyond the Fall Meeting, AGU is piloting a new program that is entirely virtual. This virtual program, called Mentoring365, is designed to have a diverse set of mentees and mentors interacting over a three-month period. Mentoring365 offers participants with a mentor that they can "meet and interact with" outside of Fall Meeting and potentially continue a relationship beyond the duration of the program. It is intended to build or add to a student's professional network and provide a student with additional support outside their research, academic, and/or graduate advisor. This presentation will highlight some of the features of the program as well as provide insight into the progress of the Mentoring365 pilot. The ultimate intent is to expand the program efficacy by collaborating across organizations in the Earth and space sciences to provide a robust and diverse pool of mentors and mentees.

The Updated AGU Ethics Policy: Supporting Inclusive and Diverse Field and Lab Environments within the Geosciences.

Science.gov (United States)

Williams, B. M.; McPhaden, M. J.; Gundersen, L. C.

2017-12-01

The American Geophysical Union (AGU), a scientific society of >60,000 members worldwide, has established a set of scientific integrity and professional ethics guidelines for the actions of its members, for the governance of the union in its internal activities, and for the operations and participation in its publications and scientific meetings. More recently AGU has undertaken actions to help address the issue of harassment in the sciences and other work climate issues; and, where applied more broadly as a code of standard behavior, will help address tangential issues of diversity and inclusion. This presentation will highlight the proposed policy changes and additional resources now in place, as they apply to field and lab environments. Progress to date and remaining challenges of this effort will be discussed, including AGU's work to provide additional program strength in the areas of Ethics, Diversity and Inclusion.

Stress distribution in the 16MND5 bainitic steel. Experimental analysis and polycrystalline modelling

International Nuclear Information System (INIS)

Pesci, R.; Inal, K.; Berveiller, M.; Masson, R.

2003-01-01

The 16MND5 bainitic steel being a two-phase material (ferrite/cementite), the X-Ray Diffraction (XRD) is the most efficient tool to determine the stress states into the ferritic phase (sin 2 ψ method). The latter, coupled to the observations realized during tensile tests (specimen surface and facies), have permitted to establish criteria to describe the behavior and the damaging processes of the material on a crystallographic scale, in the lower part of the ductile-to-brittle transition region and at lower temperatures [-196 deg. C;-60 deg. C]. During the loading, the damage is observed with a Scanning Electron Microscope, while the internal stresses are determined by XRD: the stress states are less important in ferrite than in bainite (macroscopic stress), the difference not exceeding 150 MPa. A multi-scale polycrystalline model is developed concurrently with the experimental measurements: a Mori-Tanaka formulation is used to describe the elastoplastic behavior of a ferritic single crystal reinforced by cementite precipitates, while the transition to the polycrystal is achieved by a self-consistent approach. The developed modeling takes into account the temperature effects on the stress states in each phase and includes a cleavage criterion (critical value of the stress normal to [100] planes), which expresses the damage of the material: thus, it enables to predict the actual experimental behavior of the 16MND5 steel in relation to temperature, and to take into account the failure process which is fragile from -120 deg. C. Besides, it is also possible to calculate the strains of the diffracting planes, which can be compared to those measured by XRD: this enables to evaluate the heterogeneity of the strains for each crystallographic orientation. (authors)

AGU and Wiley-Blackwell to partner on publication of journals and books

Science.gov (United States)

McEntee, Chris

2012-07-01

AGU has signed a memorandum of understanding (MOU) with Wiley-Blackwell to partner in journal and book publishing. The agreement, effective 1 January 2013, is a significant step forward in transforming AGU publishing consistent with our strategic plan goal of scientific leadership and collaboration. Wiley-Blackwell is the international scientific, technical, medical, and scholarly publishing business of John Wiley & Sons, Inc. Family-owned and publicly traded on the New York Stock Exchange, the company is strong in every major academic and professional field and partners with many of the world's leading societies. Wiley-Blackwell, a leader in developing models for open access and providing developing nations with access to science, publishes nearly 1500 peer-reviewed journals and more than 1500 new books annually. The company publishes approximately 700 society titles.

Scientific Integrity and Professional Ethics at AGU - Strategies and Actions to Impact Sexual Harassment in Science and other Work Climate Issues

Science.gov (United States)

McPhaden, Michael; Davidson, Eric; McEntee, Christine; Williams, Billy

2017-04-01

The American Geophysical Union (AGU), a scientific society of 62,000 members worldwide, has established a set of scientific integrity and professional ethics guidelines for the actions of its members, for the governance of the union in its internal activities, and for the operations and participation in its publications and scientific meetings. More recently AGU has undertaken strategies and actions to help address the issue of harassment in the sciences and other work climate issues. This presentation will provide an overview of the role of scientific societies in helping to address these important issues, as well as specific strategies and actions underway at AGU and other societies. Progress to date and remaining challenges of this effort will be discussed, including AGU's work to provide additional program strength in this area.

CO2 Emissions Generated by a Fall AGU Meeting

Science.gov (United States)

osborn, G.; Malowany, K. S.; Samolczyk, M. A.

2011-12-01

The process of reporting on and discussing geophysical phenomena, including emissions of greenhouse gases, generates more greenhouse gases. At the 2010 fall meeting of the AGU, 19,175 delegates from 81 countries, including, for example, Eritrea, Nepal, and Tanzania, traveled a total of 156,000,000 km to congregate in San Francisco for five days. With data on home bases of participants provided by AGU, we estimated the CO2 emissions generated by travel and hotel stays of those participants. The majority of the emissions from the meeting resulted from air travel . In order to estimate the footprint of such travel, (a) distances from the largest airport in each country and American state (except Canada and California) to San Francisco were tabulated , (b) basic distances were converted to emissions using the TerraPass (TRX Travel Analytics) carbon calculator, (c) it was assumed that half the California participants would fly and half would drive, (d) it was assumed that half of Canadians would fly out of Toronto and half out of Vancouver, and (e) a fudge factor of 10% was added to air travel emissions to account for connecting flights made by some participants to the main airports in the respective countries (connecting flights are disproportionately significant because of high output during takeoff acceleration). Driving impacts were estimated with a Transport Direct/RAC Motoring Services calculator using a 2006 Toyota Corolla as a standard car. An average driving distance of 50 km to the departure airport, and from the airport upon return, was assumed. Train impacts were estimated using the assumption that all flying participants would take BART from SFO. Accomodation impacts were estimated using an Environmental Protection Agency calculator, an assumed average stay of 3 nights, and the assumption that 500 participants commuted from local residences or stayed with friends. The above assumptions lead to an estimate, which we consider conservative, of 19 million kg of

Kuidas matemaatikat õpilasele kergemaks ja põnevamaks õppeaineks muuta? / Raivo Juurak

Index Scriptorium Estoniae

Juurak, Raivo, 1949-

2016-01-01

Vestlusring toimus videokonverentsina ning selles osalesid matemaatikaõpetajad Hele Kiisel Treffneri gümnaasiumist, Agu Ojasoo GAG-ist ja Maksim Ivanov Annelinna gümnaasiumist (viimasest osales ka õppealajuhataja Jelena Bitova), matemaatika õppejõud Terje Hõim ning interneti kaudu Sirje Pihlap TÜ-st, Tiia Lister koolituskeskusest Tulevikuhariduse PIRN, Aado Luik tarbijakaitsest, Kaja Jakobson SA Innovest ning Pille Liblik, Mariann Rikka ja Aivar Ots HTM-ist

[comment t[Comment on] “What is AGU's proper role in society?”] AGU's role in society: Duty to the public

Science.gov (United States)

Wilshire, Howard

Bravo to William Kaula and Don Anderson for their forthright opinion, “What Is AGU's Proper Role in Society?” (Eos, April 9, 1991). In hearing preliminaries about Mission to Planet Earth at the Geological Society of America's meeting in Phoenix in 1987, I was turned off by what seemed to me to be endless self-serving proposals to probe the Earth “with our steely knives,” but with hardly a mention of how we could use the information to assist the nation in making rational decisions about the future human occupancy of Earth. I concur with Kaula and Anderson that it is not only the duty of individual scientists to speak out on controversial issues of public concern, but also the duty of professional societies to influence the public policy decision-making process in areas where our special expertise is relevant.It does not matter that opinions within the professional societies differ. Opinions within the nation differ, too. But to take no position at all because of these differences of opinion is dereliction of our duty to the public that supports us. AGU already has a mechanism for presenting a Union-endorsed position on public issues (which could serve as a model for other professional societies whose best effort is to hide under the bed). This mechanism needs to be used more aggressively so that our expert knowledge (both of facts and hypotheses) is brought to bear on matters of critical human concern.

Evaluation of a gadolinium-based nanoparticle (AGuIX) for contrast-enhanced MRI of the liver in a rat model of hepatic colorectal cancer metastases at 9.4 tesla

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Fries, P.; Morr, D.; Mueller, A.; Massmann, A.; Seidel, R.; Schneider, G.; Buecker, A. [Saarland University Medical Center, Homburg (Germany). Clinic of Diagnostic and Interventional Radiology; Lux, F.; Tillement, O. [Universite Claude Bernard, Lyon (France). Laboratoire de Physico-Chimie des Materiaux Luminescents; Schaefer, T. [Saarland University Medical Center, Homburg (Germany). Dept. of General, Visceral and Pediatric Surgery; Menger, M.D. [Saarland University Medical Center, Homburg (Germany). Inst. for Clinical and Experimental Surgery

2015-12-15

The aim of this study was to compare a Gd-based nanoparticle (AGuIX) with a standard extracellular Gd-based contrast agent (Gd-DOTA) for MRI at 9.4 T in rats with hepatic colorectal cancer metastases. 12 rats with hepatic metastases were subjected to MRI using a 9.4 T animal scanner. T1w self-gated FLASH sequences (TR/TE=45/2.5 ms, alpha = 45 , TA=1: 23 min, FOV=5.12 x 5.12 cm{sup 2}, matrix = 256 x 256) were acquired before and at 10 time points after contrast injection. Each animal received 0.1 mmol/kg BW Gd-DOTA i.v. 2 days later AGuIX was applied at 0.01 mmol/kg BW (representing equal Gd doses). The SNR of normal liver (SNRliver), hyper- and hypoenhancing parts of tumors (SNRtumor, hyperenh/SNRtumor, hypoenhanc), erector spinae muscle (SNRmuscle), CNR and lesion enhancement (LE) were calculated based on ROI measurements. Mean SNRliver (Gd-DOTA: 14.6 ± 0.7; AGuIX: 28.2 ± 2.6, p < 0.001), SNRtumor, hyperenhanc (Gd-DOTA: 18.6 ± 1.2; AGuIX: 29.6 ± 2.8, p < 0.001), SNRtumor, hypoenhanc (Gd-DOTA: 12.0 ± 0.7; AGuIX: 15.4 ± 0.7, p < 0.001), SNRmuscle (Gd-DOTA: 12.3 ± 0.3; AGuIX: 14.0 ± 0.7, p < 0.001), mean CNR (Gd-DOTA: -2.5 ± 0.2; AGuIX: -7.5 ± 1.0, p < 0.001) and LE (Gd-DOTA: 3.8 ± 0.7; AGuIX: 14.9 ± 2.8, p=0.001) were significantly higher using AGuIX. Regardless of the larger molecular size, AGuIX demonstrates an early peak enhancement followed by a continuous washout. AGuIX provides better enhancement at 9.4 T compared to Gd-DOTA for equal doses of applied Gd. This is based on the molecule structure and the subsequent increased interaction with protons leading to a higher relaxivity. AGuIX potentially ameliorates the conspicuity of focal liver lesions and may improve the sensitivity in diagnostic imaging of malignant hepatic tumors.

Evaluation of a gadolinium-based nanoparticle (AGuIX) for contrast-enhanced MRI of the liver in a rat model of hepatic colorectal cancer metastases at 9.4 tesla

International Nuclear Information System (INIS)

Fries, P.; Morr, D.; Mueller, A.; Massmann, A.; Seidel, R.; Schneider, G.; Buecker, A.; Lux, F.; Tillement, O.; Schaefer, T.; Menger, M.D.

2015-01-01

The aim of this study was to compare a Gd-based nanoparticle (AGuIX) with a standard extracellular Gd-based contrast agent (Gd-DOTA) for MRI at 9.4 T in rats with hepatic colorectal cancer metastases. 12 rats with hepatic metastases were subjected to MRI using a 9.4 T animal scanner. T1w self-gated FLASH sequences (TR/TE=45/2.5 ms, alpha = 45 , TA=1: 23 min, FOV=5.12 x 5.12 cm 2 , matrix = 256 x 256) were acquired before and at 10 time points after contrast injection. Each animal received 0.1 mmol/kg BW Gd-DOTA i.v. 2 days later AGuIX was applied at 0.01 mmol/kg BW (representing equal Gd doses). The SNR of normal liver (SNRliver), hyper- and hypoenhancing parts of tumors (SNRtumor, hyperenh/SNRtumor, hypoenhanc), erector spinae muscle (SNRmuscle), CNR and lesion enhancement (LE) were calculated based on ROI measurements. Mean SNRliver (Gd-DOTA: 14.6 ± 0.7; AGuIX: 28.2 ± 2.6, p < 0.001), SNRtumor, hyperenhanc (Gd-DOTA: 18.6 ± 1.2; AGuIX: 29.6 ± 2.8, p < 0.001), SNRtumor, hypoenhanc (Gd-DOTA: 12.0 ± 0.7; AGuIX: 15.4 ± 0.7, p < 0.001), SNRmuscle (Gd-DOTA: 12.3 ± 0.3; AGuIX: 14.0 ± 0.7, p < 0.001), mean CNR (Gd-DOTA: -2.5 ± 0.2; AGuIX: -7.5 ± 1.0, p < 0.001) and LE (Gd-DOTA: 3.8 ± 0.7; AGuIX: 14.9 ± 2.8, p=0.001) were significantly higher using AGuIX. Regardless of the larger molecular size, AGuIX demonstrates an early peak enhancement followed by a continuous washout. AGuIX provides better enhancement at 9.4 T compared to Gd-DOTA for equal doses of applied Gd. This is based on the molecule structure and the subsequent increased interaction with protons leading to a higher relaxivity. AGuIX potentially ameliorates the conspicuity of focal liver lesions and may improve the sensitivity in diagnostic imaging of malignant hepatic tumors.

President's message: Dues increase will help build the foundation for AGU's future success

Science.gov (United States)

McPhaden, Michael J.

2012-09-01

The world is a very different place than it was 43 years ago. In 1969, Jimi Hendrix rocked the legendary Woodstock music festival, Neil Armstrong took the first steps on the Moon, and U.S. drivers paid an average of 35 cents a gallon for gas. Today, digital music files have replaced vinyl records, NASA's Curiosity rover is transmitting data and imagery from the surface of Mars, and a growing number of cars run on alternative fuels. In the same way, 43 years ago AGU was a very different organization. Membership hovered around 10,000, and the Fall Meeting was still in its infancy. Today, AGU's membership has increased to more than 61,000, Fall Meeting attendance has topped 20,000, and an entire generation of geoscientists who weren't even born in 1969 now comprises 28% of our current membership.

MO-FG-BRA-07: Theranostic Gadolinium-Based AGuIX Nanoparticles for MRI-Guided Radiation Therapy

International Nuclear Information System (INIS)

Detappe, A; Rottmann, J; Kunjachan, S; Berbeco, R; Tillement, O

2015-01-01

Purpose: AGuIX are gadolinium-based nanoparticles, initially developed for MRI, that have a potential role in radiation therapy as a radiosensitizer. Our goal is to demonstrate that these nanoparticles can both be used as an MRI contrast agent, as well as to obtain local dose enhancement in a pancreatic tumor when delivered in combination with an external beam irradiation. Methods: We performed in vitro cell uptake and radiosensitization studies of a pancreatic cancer cell line in a low energy (220kVp) beam, a standard clinical 6MV beam (STD) and a flattening filter free clinical 6MV beam (FFF). After injection of 40mM of nanoparticles, a biodistribution study was performed in vivo on mice with subcutaneous xenograft pancreatic tumors. In vivo radiation therapy studies were performed at the time point of maximum tumor uptake. Results: The concentration of AGuIX nanoparticles in Panc-1 pancreatic cancer cells, determined in vitro by MRI and ICPMS, peaks after 30 minutes with 0.3% of the initial concentration (5mg/g). Clonogenic assays show a significant effect (p<0.05) when the AGuIX are coupled with MV photon irradiation (DEF20%=1.31). Similar AGuIX tumor uptake is found in vivo by both MRI and ICPMS 30 minutes after intravenous injection. For long term survival studies, the choice of the radiation dose is determined with 5 control groups (3mice/group) irradiated with 0, 5, 10, 15, and 20Gy. Afterwards, 4 groups (8mice/group) are used to evaluate the effect of the nanoparticles. A Logrank test is performed as a statistical test to evaluate the effect of the nanoparticles. Conclusion: The combination of the MRI contrast and radiosensitization properties of gadolinium nanoparticles reveals a strong potential for usage with MRI-guided radiation therapy

Charting a path forward: building AGU's capacity to help foster scientist-decision maker engagement

Science.gov (United States)

Vano, J. A.; Behar, D. H.; Mote, P.; Ferguson, D. B.; Pandya, R.

2016-12-01

Most research proposals, papers, and presentation abstracts begin with the motivation that the new science presented will benefit society. Behind this, beyond making good on the promises to get funding, is a sincere effort to contribute our knowledge and talent to build a better (safer, sustainable, more resilient) world. For this to happen, however, the science needs to be connected to people in communities who make decisions. While this happens in a variety of ways, often for research to be most useful to society, engagement with decision makers should occur at the beginning and throughout the research process. Increasingly this is being recognized as important, as evidenced by the growing number of boundary organizations (e.g., U.S. Department of the Interior's Climate Science Centers, NOAA's Regional Integrated Sciences and Assessment programs). Even within AGU, in recent years there has been a number of new activities and networks that suggest a growing community of practice for those doing work at the science-society interface (e.g., The Thriving Earth Exchange, the Water and Society Technical Committee in the Hydrology Section). In this presentation, we highlight what these activities are and share insights from those involved. We evaluate trends (e.g., have the number of abstracts on this topic increased?) and present responses from AGU members to questions on where this community of practice should go next (e.g., What is the most important task the AGU community should do to improve decision maker-scientist engagement?). The goal of this presentation is to promote a conversation about how the AGU community can be better prepared to foster engagement with decision makers that will lead to more actionable science. This will help us ensure our science is useful to society, fulfilling our motivations, and arguably responsibilities, both individually and as a community. It will also serve to prepare new scientists for a broader range of careers beyond

Influence of metallurgical phase transformation on crack propagation of 15-5PH stainless steel and 16MND5 low carbon steel

International Nuclear Information System (INIS)

Liu, J.

2012-01-01

This study focuses on the effects of phase transformations on crack propagation. We want to understand the changes of fracture toughness during welding. In this work, fracture toughness is expressed by J-integral. There are many experimental methods to obtain the critical toughness JIC but they are impractical for our investigation during phase transformation. That is the reason why we have proposed a method coupling mechanical tests, digital image correlation and finite element simulation. The fracture tests are implemented on pre-cracked single edge notched plate sample which is easy for machining and heat conduct during phase transformation. The tests are conducted at different temperatures until rupture. Digital image correlation gives us the displacement information on every sample. Each test is then simulated by finite element where the fracture toughness is evaluated by the method G-Theta at the crack propagation starting moment found by potential drop method and digital image correlation technical. Two materials have been studied, 15Cr-5Ni martensitic precipitation hardening stainless steel and 16MND5 ferritic low carbon steel. For these two materials, different test temperatures were chosen before, during and after phase transformation for testing and failure characterization of the mechanical behavior. Investigation result shows that metallurgical phase transformation has an influence on fracture toughness and further crack propagation. For 15-5PH, the result of J1C shows that the as received 15-5PH has higher fracture toughness than the one at 200 C. The toughness is also higher than the original material after one cycle heat treatment probably due to some residual austenite. Meanwhile, pure austenite 15-5PH at 200 C has higher fracture toughness than pure martensitic 15-5PH at 200 C. For 16MND5, the result also proves that the phase transformation affects fracture toughness. The as received material has bigger J1C than the situation where it was heated

Reply to Comments on “AGU Statement: Investigation of Scientists and Officials in L'Aquila, Italy, Is Unfounded”

Science.gov (United States)

McPhaden, Michael

2010-10-01

It is critical to recognize the benefits and limitations of scientific knowledge, particularly when it comes to predicting hazards. I agree with G. J. Wasserburg that AGU should help scientists communicate their work accurately and understandably so it can provide the greatest value to society. This objective is explicit in AGU's new strategic plan (http://www.agu.org/about/strategic_plan.shtml) and is consistent with our vision of both advancing and communicating Earth and space science to ensure a sustainable future. We as a community have an obligation to increase the role of science in informing policy to mitigate the impacts of natural disasters. Such efforts require an open exchange of ideas and information and a clear understanding of the limitations of our knowledge. In response to Flavio Dobran, I agree that scientists are not above the law and, like all citizens, must be held accountable for their actions. However, laws and lawmakers must also recognize what science can and cannot do. We cannot yet reliably predict precisely when earthquakes will occur.

The synthesis and crystal structures of the first rare-earth alkaline-earth selenite chlorides MNd10(SeO3)12Cl8 (M=Ca and Sr)

International Nuclear Information System (INIS)

Berdonosov, P.S.; Olenev, A.V.; Dolgikh, V.A.; Lightfoot, P.

2007-01-01

Two new alkaline-earth Nd selenite chlorides MNd 10 (SeO 3 ) 12 Cl 8 (M=Ca, Sr) were obtained using crystal growth from alkaline-earth chloride melts in quartz tubes. These new compounds crystallize in the orthorhombic system in space group C cca (no. 68). The compounds were studied by energy dispersive X-ray spectroscopy (EDX) and X-ray diffraction. It was shown that both compounds adopt the same structure type, constructed by complex [M 11 (SeO 3 ) 12 ] 8+ slabs separated by chloride anion layers perpendicular to the longest cell parameter. The SeO 3 groups show a pyramidal shape and may be described as SeO 3 E tetrahedra. Such SeO 3 groups decorate the Nd-O skeletons forming the [M 11 (SeO 3 ) 12 ] 8+ slabs. - Graphical abstract: Two new alkaline-earth Nd selenite chlorides MNd 10 (SeO 3 ) 12 Cl 8 (M=Ca, Sr) were synthesized. These structures are constructed by [M 11 (SeO 3 ) 12 ] 8+ slabs separated by chloride anion layers

Expression of the Agmatine Deiminase Pathway in Enterococcus faecalis Is Activated by the AguR Regulator and Repressed by CcpA and PTSMan Systems

Science.gov (United States)

Blancato, Víctor S.; Magni, Christian

2013-01-01

Although the agmatine deiminase system (AgDI) has been investigated in Enterococcus faecalis, little information is available with respect to its gene regulation. In this study we demonstrate that the presence of exogenous agmatine induces the expression of agu genes in this bacterium. In contrast to the homologous and extensively characterized AgDI system of S. mutants, the aguBDAC operon in E. faecalis is not induced in response to low pH. In spite of this, agmatine catabolism in this bacterium contributes by neutralizing the external medium while enhancing bacterial growth. Our results indicate that carbon catabolic repression (CCR) operates on the AgDI system via a mechanism that involves interaction of CcpA and P-Ser-HPr with a cre site found in an unusual position considering the aguB promoter (55 nt upstream the +1 position). In addition, we found that components of the mannose phosphotransferase (PTSMan) system also contributed to CCR in E. faecalis since a complete relief of the PTS-sugars repressive effect was observed only in a PTSMan and CcpA double defective strain. Our gene context analysis revealed that aguR is present in oral and gastrointestinal microorganisms. Thus, regulation of the aguBDAC operon in E. faecalis seems to have evolved to obtain energy and resist low pH conditions in order to persist and colonize gastrointestinal niches. PMID:24155893

Eesti ülikoolid janunevad muutuste järele : ülikool tegi plaane järgnevaks kuueks aastaks / Marju Himma ; kommenteerivad Peeter Kreitzberg, Tõnis Rüütel, Olga Tšerjomuškina ja Raivo Vare

Index Scriptorium Estoniae

Himma, Marju

2008-01-01

7. novembril 2008 toimunud Tartu Ülikooli arengukonverentsist. Arvamust avaldavad Riigikogu kultuurikomisjoni esimees Peeter Kreitzberg, Tartu Ülikooli geograafiatudeng Tõnis Rüütel, Eesti Üliõpilaskondade Liidu aseesimees Olga Tšerjomuškina ja Tartu Ülikooli kuratooriumi liige Raivo Vare. Konverentsil esines ka president Toomas Hendrik Ilves

Expression of the agmatine deiminase pathway in Enterococcus faecalis is activated by the AguR regulator and repressed by CcpA and PTS(Man systems.

Directory of Open Access Journals (Sweden)

Cristian Suárez

Full Text Available Although the agmatine deiminase system (AgDI has been investigated in Enterococcus faecalis, little information is available with respect to its gene regulation. In this study we demonstrate that the presence of exogenous agmatine induces the expression of agu genes in this bacterium. In contrast to the homologous and extensively characterized AgDI system of S. mutants, the aguBDAC operon in E. faecalis is not induced in response to low pH. In spite of this, agmatine catabolism in this bacterium contributes by neutralizing the external medium while enhancing bacterial growth. Our results indicate that carbon catabolic repression (CCR operates on the AgDI system via a mechanism that involves interaction of CcpA and P-Ser-HPr with a cre site found in an unusual position considering the aguB promoter (55 nt upstream the +1 position. In addition, we found that components of the mannose phosphotransferase (PTS(Man system also contributed to CCR in E. faecalis since a complete relief of the PTS-sugars repressive effect was observed only in a PTS(Man and CcpA double defective strain. Our gene context analysis revealed that aguR is present in oral and gastrointestinal microorganisms. Thus, regulation of the aguBDAC operon in E. faecalis seems to have evolved to obtain energy and resist low pH conditions in order to persist and colonize gastrointestinal niches.

Research in rock deformation: Report of the Second Rock Deformation Colloquium, 1989 AGU Spring Meeting

Science.gov (United States)

Green, Harry

In response to the considerable interest expressed at the first Rock Deformation Colloquium held at the Fall 1988 AGU meeting in San Francisco, a second dinner meeting was held on Monday evening, May 8, 1989, at the Omni Hotel in Baltimore. The principal business items were a report by Steve Kirby (U.S. Geological Survey, Menlo Park, Calif.) concerning the meeting the previous day of the rock deformation steering committee and an after dinner presentation by Steve Freiman of the National Institute of Standards and Technology in Gaithersburg, Md., entitled “The Environmental Effects on Subcritical Crack Growth.” Kirby reported that a technical committee for rock deformation has been established within the Tectonophysics Section of AGU; the steering committee will attempt to establish constructive working relations with allied societies and disciplines, such as ceramics, metallurgy, materials science, structural geology, and surface science. Brian Evans of the Massachusetts Institute of Technology in Cambridge, Terry Tullis of Brown University in Providence, R.I., and Harry Green of the University of California at Davis agreed to be a subcommittee to propose a name for the technical committee, for discussion at the next steering committee meeting to be held before the 1989 Fall AGU meeting. Green also agreed to investigate the possibility of convening a special session at the Fall Meeting on the nature and mechanism of deep-focus earthquakes. (The session is Deep Slab Deformation and Faulting, T21B and T22A, organized by Harry and Ken Creager of the University of Washington, Seattle; it will be all day on Tuesday, December 5.)

Millist eriala soovitate keskkoolilõpetajatele edasiõppimiseks? / Karmel Eikner, Reet Hääl, Agu Laanemets, Jaanus Laugus

Index Scriptorium Estoniae

2010-01-01

Küsimusele vastavad ettevõtja, Powered by Karmeli brändijuht Karmel Eikner, MTÜ Eesti Liisingühingute Liidu tegevdirektor Reet Hääl, OÜ Kvintessents juhatuse liige Agu Laanemets ja OÜ Uus Maa Kinnisvaragrupi juhatuse esimees Jaanus Laugus

Space Weather Research Presented at the 2007 AGU Fall Meeting

Science.gov (United States)

Kumar, Mohi

2007-12-01

AGU's 47th annual Fall Meeting, held 10-14 December 2007 in San Francisco, Calif., was the largest gathering of geoscientists in the Union's history. More than 14,600 people attended. The Space Physics and Aeronomy (SPA) sections sported excellent turnout, with more than 1300 abstracts submitted over 114 poster and oral sessions. Topics discussed that related to space weather were manifold: the nature of the Sun-Earth system revealed through newly launched satellites, observations and models of ionospheric convection, advances in the understanding of radiation belt physics, Sun-Earth coupling via energetic coupling, data management and archiving into virtual observatories, and the applications of all this research to space weather forecasting and prediction.

The AGU Hydrology Student Subcommittee (H3S) - fostering the Fall Meeting experience for young hydrologists

Science.gov (United States)

Claes, N.; Beria, H.; Brown, M. R. M.; Kumar, A.; Goodwell, A. E.; Preziosi-Ribero, A.; Morris, C. K.; Cheng, F. Y.; Gootman, K. S.; Welsh, M.; Khatami, S.; Knoben, W.

2017-12-01

The AGU Hydrology Section Student Subcommittee (H3S), the student body of the AGU hydrology section, caters to the needs of students and early career scientists whose research interests contain a hydrological component. The past two years, H3S organized a Student and Early Career Scientist conference addressing both the technical and research needs of young hydrologists. Over the past several years, H3S organized pop-up sessions in Water Sciences and Social Dimensions of Geosciences which allowed young hydrologists to share and learn from their collective experiences. Social events like the early career social mixer, co-organized with CUAHSI, led to increased networking opportunities among peers. Continuous social media engagement led to a general dialogue within the community over varied issues including research productivity, gender equality, etc. Ice-breaker events between junior and senior academics encouraged young hydrologists to talk with their academic crushes and continuously seek out mentorship opportunities. Collating our past experiences, we ponder over our accomplishments, failures, and opportunities to improve representation of early career hydrologists within the community.

Microstructure and Ductility-Dip Cracking Susceptibility of Circumferential Multipass Dissimilar Weld Between 20MND5 and Z2CND18-12NS with Ni-Base Filler Metal 52

Science.gov (United States)

Qin, Renyao; Duan, Zhaoling; He, Guo

2013-10-01

The large circumferential multipass dissimilar weld between 20MND5 steel and Z2CND18-12NS stainless steel welded with FM52 filler material was investigated in terms of the diluted composition, the grain boundary precipitation, and the ductility-dip cracking (DDC) susceptibility of the weld. The diluted composition of the weld is composed of 37 to 47 pct Ni, 21 to 24 pct Cr, and 28 to 40 pct Fe, which are inhomogeneous along the depth and over the width of the deep weld. The carbon content has a distribution in the region of the surface weld from a high level (~0.20 pct) in the zone near 20MND5 steel to a normal level (~0.03 pct) in the zone near Z2CND18-12NS stainless steel. The carbon distribution is corresponding to the grain boundary carbides. The minimum threshold strains for DDC occur in the temperature range of 1223 K to 1323 K (950 °C to 1050 °C), which are 0.5, 0.35, and 0.4 pct for the root weld, middle region, and the surface weld, respectively. The dissimilar weld has the largest susceptibility to the DDC compared to the filler metal 52 and the Inconel 690.

aguA, the gene encoding an extracellular alpha-glucuronidase from Aspergillus tubingensis, is specifically induced on xylose and not on glucuronic acid.

Science.gov (United States)

de Vries, R P; Poulsen, C H; Madrid, S; Visser, J

1998-01-01

An extracellular alpha-glucuronidase was purified and characterized from a commercial Aspergillus preparation and from culture filtrate of Aspergillus tubingensis. The enzyme has a molecular mass of 107 kDa as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and 112 kDa as determined by mass spectrometry, has a determined pI just below 5.2, and is stable at pH 6.0 for prolonged times. The pH optimum for the enzyme is between 4.5 and 6.0, and the temperature optimum is 70 degrees C. The alpha-glucuronidase is active mainly on small substituted xylo-oligomers but is also able to release a small amount of 4-O-methylglucuronic acid from birchwood xylan. The enzyme acts synergistically with endoxylanases and beta-xylosidase in the hydrolysis of xylan. The enzyme is N glycosylated and contains 14 putative N-glycosylation sites. The gene encoding this alpha-glucuronidase (aguA) was cloned from A. tubingensis. It consists of an open reading frame of 2,523 bp and contains no introns. The gene codes for a protein of 841 amino acids, containing a eukaryotic signal sequence of 20 amino acids. The mature protein has a predicted molecular mass of 91,790 Da and a calculated pI of 5.13. Multiple copies of the gene were introduced in A. tubingensis, and expression was studied in a highly overproducing transformant. The aguA gene was expressed on xylose, xylobiose, and xylan, similarly to genes encoding endoxylanases, suggesting a coordinate regulation of expression of xylanases and alpha-glucuronidase. Glucuronic acid did not induce the expression of aguA and also did not modulate the expression on xylose. Addition of glucose prevented expression of aguA on xylan but only reduced the expression on xylose.

aguA, the Gene Encoding an Extracellular α-Glucuronidase from Aspergillus tubingensis, Is Specifically Induced on Xylose and Not on Glucuronic Acid

Science.gov (United States)

de Vries, Ronald P.; Poulsen, Charlotte H.; Madrid, Susan; Visser, Jaap

1998-01-01

An extracellular α-glucuronidase was purified and characterized from a commercial Aspergillus preparation and from culture filtrate of Aspergillus tubingensis. The enzyme has a molecular mass of 107 kDa as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and 112 kDa as determined by mass spectrometry, has a determined pI just below 5.2, and is stable at pH 6.0 for prolonged times. The pH optimum for the enzyme is between 4.5 and 6.0, and the temperature optimum is 70°C. The α-glucuronidase is active mainly on small substituted xylo-oligomers but is also able to release a small amount of 4-O-methylglucuronic acid from birchwood xylan. The enzyme acts synergistically with endoxylanases and β-xylosidase in the hydrolysis of xylan. The enzyme is N glycosylated and contains 14 putative N-glycosylation sites. The gene encoding this α-glucuronidase (aguA) was cloned from A. tubingensis. It consists of an open reading frame of 2,523 bp and contains no introns. The gene codes for a protein of 841 amino acids, containing a eukaryotic signal sequence of 20 amino acids. The mature protein has a predicted molecular mass of 91,790 Da and a calculated pI of 5.13. Multiple copies of the gene were introduced in A. tubingensis, and expression was studied in a highly overproducing transformant. The aguA gene was expressed on xylose, xylobiose, and xylan, similarly to genes encoding endoxylanases, suggesting a coordinate regulation of expression of xylanases and α-glucuronidase. Glucuronic acid did not induce the expression of aguA and also did not modulate the expression on xylose. Addition of glucose prevented expression of aguA on xylan but only reduced the expression on xylose. PMID:9440512

AGuIX, a theranostic nano-particle to improve image-guided radiation therapy: a proof of concept in pancreatic cancer

International Nuclear Information System (INIS)

Detappe, Alexandre

2017-01-01

Previous studies demonstrated AGuIX ability to act as an efficient radiosensitizer under the presence of preclinical radiations or monoenergetic radiation beams for multiple cancer models. The preclinical irradiation (220 kV) has been shown effective in activating high atomic number (Z) nanoparticles. The energy peak is close to the k-edge of the different high-Z elements used (50.2 keV for the gadolinium), leading to a strong photoelectric effect. Auger electrons generation and biological effects occur afterwards creating a local dose enhancement. However, clinical treatments use a higher energy beam (≥6 MV). At these energy ranges, the photoelectric probability is less important, decreasing the direct interaction of the nanoparticles with the incoming photons. We performed a proof of concept on a pancreatic tumor model, known for its low survival rates, with preclinical and clinical radiation beams to evaluate the efficacy of the AGuIX. To increase the efficacy of the clinical radiation beam without modifying the nanoparticle structure in order to obtain a dose enhancement close to the one observed with the preclinical beam, we evaluated key clinical beam parameters to understand and increase the mechanisms of interaction between the incident photons and the high-Z nanoparticles. Hence, we evaluated analytically the impact of the radiation beam under different conditions of irradiation, confirming the potential of the AGuIX with a preclinical beam, and finally shown their significant efficacy under a clinical setup. This study is the first to evaluate the potential of a high-Z nanoparticle to act as radiosensitizer following low dose intravenous injections. (author)

7 years of MacGyver sessions at EGU and AGU: what happened?

Science.gov (United States)

Hut, Rolf; Selker, John; Weijs, Steven; Luxemburg, Wim; Wickert, Andy; Blume, Theresa; Bamburger, Jan; Stoof, Cathelijne; Tauro, Flavia

2016-04-01

The session that this poster is in, the: "Self-made sensors and unintended use of measurement equipment", also known as the "MacGyver-session" has had 7 years of scientists contributing their self made devices, hacks and solutions with the hydrological community. In 2009, the first session was held at the AGU fall meeting and since 2011 a session is also organised at the EGU General Assembly. On this poster, and in the accompanying review paper, we will present an overview of the work presented in the last 7 years, cataloging the work of the inventive scientists who have contributed to these successful, and above all: fun, sessions.

Space station astronauts discuss life in space during AGU interview

Science.gov (United States)

Showstack, Randy

2012-07-01

Just one day after China's Shenzhou-9 capsule, carrying three Chinese astronauts, docked with the Tiangong-1 space lab on 18 June, Donald Pettit, a NASA astronaut on the International Space Station (ISS), said it is “a step in the right direction” that more people are in space. “Before they launched, there were six people in space,” he said, referring to those on ISS, “and there are 7 billion people on Earth.” The astronauts were “like one in a billion. Now there are nine people in space,” Pettit said during a 19 June interview that he and two other astronauts onboard ISS had with AGU. Pettit continued, “So the gradient of human beings going into space is moving in the right direction. We need to change these numbers so that more and more human beings can call space their home so we can expand off of planet Earth and move out into our solar system.”

Investigation of the high temperature behaviour of an unsteady crack growth in 16MND5 steel and application to the calculation of vessel bottom failure in case of severe accident

International Nuclear Information System (INIS)

Tardif, N.

2009-01-01

This research thesis deals with the prediction of the failure of a pressurized water reactor under an accidental thermo-mechanical loading. This study is based on tests performed on an instrumented mock-up and on the comparison of experimental results obtained on two different 16MND15 steel grades with numerical simulation results. The test model is a tube submitted to tension and inner pressure. Temperatures, strains and pressure are measured and images are acquired by two rapid digital cameras and an infrared camera. Crack initiation and propagation conditions are acquired. Simulations are performed using finite elements and the ABAQUS code. Crack initiation and growth are modelled by a cohesive area method. Strain rates are also studied

Guidelines for the preclinical in vivo evaluation of pharmacological active drugs for ALS/MND: report on the 142nd ENMC international workshop.

Science.gov (United States)

Ludolph, Albert C; Bendotti, Caterina; Blaugrund, Eran; Hengerer, Bastian; Löffler, Jean-Philippe; Martin, Joanne; Meininger, Vincent; Meyer, Thomas; Moussaoui, Saliha; Robberecht, Wim; Scott, Sean; Silani, Vincenzo; Van Den Berg, Leonard H

2007-08-01

A transgenic animal model for anterior horn cell loss was established in 1994. This model is based on the insertion of a high copy number of disease-causing human Cu/Zn SOD mutations into the intact mouse genome. It serves to establish hypotheses for the pathogenesis of anterior horn cell death, but also to test potential pharmacological approaches to therapy in human ALS. Today, more than 100 -- published and unpublished -- compounds have been tested in this animal model, a large part of them being reported as successful. However, it proved to be difficult to translate these therapeutic successes in the animal model into human trials. Also, a number of disease-modifying strategies were difficult to reproduce, even by the same group. On the other hand, the step from mice to men means a huge investment for the sponsors of clinical trials and the scientific community. Therefore, establishment of standard methods for drug testing in ALS models is mandatory. In this workshop, clinical and preclinical researchers established in the field of ALS/MND met in Holland in March 2006 in order to establish guidelines for the community for drug testing in mouse models.

Isevärki kontorid / Liivi Tamm

Index Scriptorium Estoniae

Tamm, Liivi, 1978-

2009-01-01

Raivo Raidvee sisekujundusest MTV Eesti kontorile ja Maarja Mikkeni sisekujundusest brändingufirma Bränd Manual kontorile arhitektide Andrus Kõresaare ja Raivo Kotovi (KOKO Arhitektid) kavandatud tornidega majas Rotermanni kvartalis Roseni 7

Hotell Arensburg : Lossi 15, Kuressaare / Liina Jänes

Index Scriptorium Estoniae

Jänes, Liina, 1977-

2008-01-01

Arensburg Boutique Hotel & Spa. Arhitektid: Margit Kärner, Raivo Kotov, Lea Laidra. Sisearhitektid: Liisi Murula, Raivo Kotov, Raili Paling. Peatöövõtja: EBC Ehitus AS. I korruse plaan, 2 värv. välisvaadet, 3 sisevaadet

A micro-mechanical analysis and an experimental characterisation of the behavior and the damaging processes of a 16MND5 pressure vessel steel at low temperature; Etude micromecanique et caracterisation experimentale du comportement et de l'endommagement de l'acier de cuve 16MND5 a basses temperatures

Energy Technology Data Exchange (ETDEWEB)

Pesci, R

2004-06-15

As part of an important experimental and numerical research program launched by Electricite De France on the 16MND5 pressure vessel steel, sequenced and in-situ tensile tests are realized at low temperatures [-196 C;-60 C]. They enable to associate the observation of specimens, the complete cartography of which has been made with a scanning electron microscope (damaging processes, initiation and propagation of microcracks), with the stress states determined by X-ray diffraction, in order to establish relevant criteria. All these measurements enable to supply a two-scale polycrystalline modeling of behavior and damage (Mori-Tanaka/self-consistent) which is developed concurrently with the experimental characterization. This model proves to be a very efficient one, since it correctly reproduces the influence of temperature experimentally defined: the stress state in ferrite remains less important than in bainite (the difference never exceeds 150 MPa), whereas it is much higher in cementite. The heterogeneity of strains and stresses for each crystallographic orientation is well rendered; so is cleavage fracture normal to the {l_brace}100{r_brace} planes in ferrite (planes identified by electron back scattered diffraction during an in-situ tensile test at -150 C), which occurs sooner when temperature decreases, for a constant stress of about 700 MPa in this phase. (author)

"Anything that makes life's journey better." Exploring the use of digital technology by people living with motor neurone disease.

Science.gov (United States)

Hobson, Esther V; Fazal, Saima; Shaw, Pamela J; McDermott, Christopher J

2017-08-01

Our aim was to explore the attitudes of those living with motor neuron disease towards digital technology. Postal and online questionnaires surveyed 83 people with MND (pwMND) and 54 friends and family members (fMND). Five pwMND and five fMND underwent semi-structured interviews. 82% of pwMND and 87% of fMND use technology every day with iPads and laptops being the devices most commonly used. pwMND used technology to help them continue to participate in everyday activities such as socialising, entertainment and accessing the internet. The internet provided peer support and information about MND but information could be distressing or unreliable. Participants preferred information from professionals and official organisations. Participants were generally supportive of using of technology to access medical care. Barriers to technology, such as lack of digital literacy skills and upper limb dysfunction, and potential solutions were identified. More challenging barriers included language and cognitive difficulties, and the fear of becoming dependent on technology. Addressing the barriers identified in this research could help pwMND access technology. However, as healthcare delivery becomes more reliant on digital technology, care should be taken to ensure that those who are unable or unwilling to use technology continue to have their needs met in alternative ways.

Heavy metals in locus ceruleus and motor neurons in motor neuron disease.

Science.gov (United States)

Pamphlett, Roger; Kum Jew, Stephen

2013-12-12

The causes of sporadic amyotrophic lateral sclerosis (SALS) and other types of motor neuron disease (MND) remain largely unknown. Heavy metals have long been implicated in MND, and it has recently been shown that inorganic mercury selectively enters human locus ceruleus (LC) and motor neurons. We therefore used silver nitrate autometallography (AMG) to look for AMG-stainable heavy metals (inorganic mercury and bismuth) in LC and motor neurons of 24 patients with MND (18 with SALS and 6 with familial MND) and in the LC of 24 controls. Heavy metals in neurons were found in significantly more MND patients than in controls when comparing: (1) the presence of any versus no heavy metal-containing LC neurons (MND 88%, controls 42%), (2) the median percentage of heavy metal-containing LC neurons (MND 9.5%, control 0.0%), and (3) numbers of individuals with heavy metal-containing LC neurons in the upper half of the percentage range (MND 75%, controls 25%). In MND patients, 67% of remaining spinal motor neurons contained heavy metals; smaller percentages were found in hypoglossal, nucleus ambiguus and oculomotor neurons, but none in cortical motor neurons. The majority of MND patients had heavy metals in both LC and spinal motor neurons. No glia or other neurons, including neuromelanin-containing neurons of the substantia nigra, contained stainable heavy metals. Uptake of heavy metals by LC and lower motor neurons appears to be fairly common in humans, though heavy metal staining in the LC, most likely due to inorganic mercury, was seen significantly more often in MND patients than in controls. The LC innervates many cell types that are affected in MND, and it is possible that MND is triggered by toxicant-induced interactions between LC and motor neurons.

Heavy metals in locus ceruleus and motor neurons in motor neuron disease

Science.gov (United States)

2013-01-01

Background The causes of sporadic amyotrophic lateral sclerosis (SALS) and other types of motor neuron disease (MND) remain largely unknown. Heavy metals have long been implicated in MND, and it has recently been shown that inorganic mercury selectively enters human locus ceruleus (LC) and motor neurons. We therefore used silver nitrate autometallography (AMG) to look for AMG-stainable heavy metals (inorganic mercury and bismuth) in LC and motor neurons of 24 patients with MND (18 with SALS and 6 with familial MND) and in the LC of 24 controls. Results Heavy metals in neurons were found in significantly more MND patients than in controls when comparing: (1) the presence of any versus no heavy metal-containing LC neurons (MND 88%, controls 42%), (2) the median percentage of heavy metal-containing LC neurons (MND 9.5%, control 0.0%), and (3) numbers of individuals with heavy metal-containing LC neurons in the upper half of the percentage range (MND 75%, controls 25%). In MND patients, 67% of remaining spinal motor neurons contained heavy metals; smaller percentages were found in hypoglossal, nucleus ambiguus and oculomotor neurons, but none in cortical motor neurons. The majority of MND patients had heavy metals in both LC and spinal motor neurons. No glia or other neurons, including neuromelanin-containing neurons of the substantia nigra, contained stainable heavy metals. Conclusions Uptake of heavy metals by LC and lower motor neurons appears to be fairly common in humans, though heavy metal staining in the LC, most likely due to inorganic mercury, was seen significantly more often in MND patients than in controls. The LC innervates many cell types that are affected in MND, and it is possible that MND is triggered by toxicant-induced interactions between LC and motor neurons. PMID:24330485

Amygdala TDP-43 Pathology in Frontotemporal Lobar Degeneration and Motor Neuron Disease.

Science.gov (United States)

Takeda, Takahiro; Seilhean, Danielle; Le Ber, Isabelle; Millecamps, Stéphanie; Sazdovitch, Véronique; Kitagawa, Kazuo; Uchihara, Toshiki; Duyckaerts, Charles

2017-09-01

TDP-43-positive inclusions are present in the amygdala in frontotemporal lobar degeneration (FTLD) and motor neuron disease (MND) including amyotrophic lateral sclerosis. Behavioral abnormalities, one of the chief symptoms of FTLD, could be, at least partly, related to amygdala pathology. We examined TDP-43 inclusions in the amygdala of patients with sporadic FTLD/MND (sFTLD/MND), FTLD/MND with mutation of the C9ORF72 (FTLD/MND-C9) and FTLD with mutation of the progranulin (FTLD-GRN). TDP-43 inclusions were common in each one of these subtypes, which can otherwise be distinguished on topographical and genetic grounds. Conventional and immunological stainings were performed and we quantified the numerical density of inclusions on a regional basis. TDP-43 inclusions in amygdala could be seen in 10 out of 26 sFTLD/MND cases, 5 out of 9 FTLD/MND-C9 cases, and all 4 FTLD-GRN cases. Their numerical density was lower in FTLD/MND-C9 than in sFTLD/MND and FTLD-GRN. TDP-43 inclusions were more numerous in the ventral region of the basolateral nucleus group in all subtypes. This contrast was apparent in sporadic and C9-mutated FTLD/MND, while it was less evident in FTLD-GRN. Such differences in subregional involvement of amygdala may be related to the region-specific neuronal connections that are differentially affected in FTLD/MND and FTLD-GRN. © 2017 American Association of Neuropathologists, Inc. All rights reserved.

Micro-mechanical analysis and modelling of the behavior and brittle fracture of a french 16MND5 steel: role of microstructural heterogeneities; Analyse et modelisation micromecanique du comportement et de la rupture fragile de l'acier 16MND5: prise en compte des heterogeneites microstructurales

Energy Technology Data Exchange (ETDEWEB)

Mathieu, J.Ph

2006-10-15

Reactor Pressure Vessel is the second containment barrier between nuclear fuel and the environment. Electricite de France's reactors are made with french 16MND5 low-alloyed steel (equ. ASTM A508 Cl.3). Various experimental techniques (scanning electron microscopy, X-ray diffraction...) are set up in order to characterize mechanical heterogeneities inside material microstructure during tensile testing at different low temperatures [-150 C;-60 C]. Heterogeneities can be seen as the effect of both 'polycrystalline' and 'composite' microstructural features. Interphase (until 150 MPa in average between ferritic and bainitic macroscopic stress state) and intra-phase (until 100 MPa in average between ferritic orientations) stress variations are highlighted. Modelling involves micro-mechanical description of plastic glide, mean fields models and realistic three-dimensional aggregates, all put together inside a multi-scale approach. Calibration is done on macroscopic stress-strain curves at different low temperatures, and modelling reproduces experimental stress heterogeneities. This modelling allows to apply a local micro-mechanical fracture criterion for crystallographic cleavage. Deterministic computations of time to fracture for different carbides random selection provide a way to express probability of fracture for the elementary volume. Results are in good agreement with hypothesis made by local approach to fracture. Hence, the main difference is that no dependence to loading nor microstructure features is supposed for probability of fracture on the representative volume: this dependence is naturally introduced by modelling. (author)

Micro-mechanical analysis and modelling of the behavior and brittle fracture of a french 16MND5 steel: role of microstructural heterogeneities

International Nuclear Information System (INIS)

Mathieu, J.Ph.

2006-10-01

Reactor Pressure Vessel is the second containment barrier between nuclear fuel and the environment. Electricite de France's reactors are made with french 16MND5 low-alloyed steel (equ. ASTM A508 Cl.3). Various experimental techniques (scanning electron microscopy, X-ray diffraction...) are set up in order to characterize mechanical heterogeneities inside material microstructure during tensile testing at different low temperatures [-150 C;-60 C]. Heterogeneities can be seen as the effect of both 'polycrystalline' and 'composite' microstructural features. Interphase (until 150 MPa in average between ferritic and bainitic macroscopic stress state) and intra-phase (until 100 MPa in average between ferritic orientations) stress variations are highlighted. Modelling involves micro-mechanical description of plastic glide, mean fields models and realistic three-dimensional aggregates, all put together inside a multi-scale approach. Calibration is done on macroscopic stress-strain curves at different low temperatures, and modelling reproduces experimental stress heterogeneities. This modelling allows to apply a local micro-mechanical fracture criterion for crystallographic cleavage. Deterministic computations of time to fracture for different carbides random selection provide a way to express probability of fracture for the elementary volume. Results are in good agreement with hypothesis made by local approach to fracture. Hence, the main difference is that no dependence to loading nor microstructure features is supposed for probability of fracture on the representative volume: this dependence is naturally introduced by modelling. (author)

ESS Grupi peahoone Tallinnas, Tondil

Index Scriptorium Estoniae

2000-01-01

Staabihoone rekonstrueerimine kontorihooneks. Välisarhitektuur säilitati algsel kujul, fassaadid restaureeriti. Ajaloolised eritingimused Liivi Künnapu. Projekteerija: Arhitektibüroo Raivo Puusepp OÜ, arhitektid Raivo Puusepp, Toivo Tammik, Peeter Loo, Krista Väärtnõu, sisekujundaja Kaire Kemp-Tisler. Projekt 1999, valmis 2000. 11 ill.: korruste plaanid, vaated

Nonmotor symptoms in patients suffering from motor neuron diseases

Directory of Open Access Journals (Sweden)

Rene Günther

2016-07-01

Full Text Available Background: The recently postulated disease spreading hypothesis has gained much attention, especially for Parkinson’s disease (PD. The various nonmotor symptoms (NMS in neurodegenerative diseases would be much better explained by this hypothesis than by the degeneration of disease-specific cell populations. Motor neuron disease (MND is primarily known as a group of diseases with a selective loss of motor function. Recent evidence, however, suggests disease spreading into nonmotor brain regions also in MND. The aim of this study was to comprehensively detect NMS in patients suffering from MND.Methods: We used a self-rating questionnaire including 30 different items of gastrointestinal, autonomic, neuropsychiatric and sleep complaints (NMSQuest which is an established tool in PD patients. 90 MND patients were included and compared to 96 controls.Results: In total, MND patients reported significantly higher NMS scores (median: 7 points in comparison to controls (median: 4 points. Dribbling, impaired taste/smelling, impaired swallowing, weight loss, loss of interest, sad/blues, falling and insomnia were significantly more prevalent in MND patients compared to controls. Interestingly excessive sweating was more reported in the MND group. Correlation analysis revealed an increase of total NMS score with disease progression.Conclusions: NMS in MND patients seemed to increase with disease progression which would fit with the recently postulated disease spreading hypothesis. The total NMS score in the MND group significantly exceeded the score for the control group, but only 8 of the 30 single complaints of the NMSQuest were significantly more often reported by MND patients. Dribbling, impaired swallowing, weight loss and falling could primarily be connected to motor neuron degeneration and declared as motor symptoms in MND.

Non-Motor Symptoms in Patients Suffering from Motor Neuron Diseases.

Science.gov (United States)

Günther, René; Richter, Nicole; Sauerbier, Anna; Chaudhuri, Kallol Ray; Martinez-Martin, Pablo; Storch, Alexander; Hermann, Andreas

2016-01-01

The recently postulated "disease spreading hypothesis" has gained much attention, especially for Parkinson's disease (PD). The various non-motor symptoms (NMS) in neurodegenerative diseases would be much better explained by this hypothesis than by the degeneration of disease-specific cell populations. Motor neuron disease (MND) is primarily known as a group of diseases with a selective loss of motor function. However, recent evidence suggests disease spreading into non-motor brain regions also in MND. The aim of this study was to comprehensively detect NMS in patients suffering from MND. We used a self-rating questionnaire including 30 different items of gastrointestinal, autonomic, neuropsychiatric, and sleep complaints [NMS questionnaire (NMSQuest)], which is an established tool in PD patients. 90 MND patients were included and compared to 96 controls. In total, MND patients reported significantly higher NMS scores (median: 7 points) in comparison to controls (median: 4 points). Dribbling, impaired taste/smelling, impaired swallowing, weight loss, loss of interest, sad/blues, falling, and insomnia were significantly more prevalent in MND patients compared to controls. Interestingly, excessive sweating was more reported in the MND group. Correlation analysis revealed an increase of total NMS score with disease progression. NMS in MND patients seemed to increase with disease progression, which would fit with the recently postulated "disease spreading hypothesis." The total NMS score in the MND group significantly exceeded the score for the control group, but only 8 of the 30 single complaints of the NMSQuest were significantly more often reported by MND patients. Dribbling, impaired swallowing, weight loss, and falling could primarily be connected to motor neuron degeneration and declared as motor symptoms in MND.

Relationship between 3-Methyl-2,4-nonanedione Concentration and Intensity of Light-induced Off-odor in Soy Bean Oil.

Science.gov (United States)

Sano, Takashi; Iwahashi, Maiko; Imagi, Jun; Sato, Toshiro; Yamashita, Toshiyuki; Fukusaki, Eiichiro; Bamba, Takeshi

2016-05-01

A beany and green off-odor is developed in soy bean oil (SBO) under light-induced oxidative conditions. 3-Methyl-2,4-nonanedione (3-MND) was inferred as the compound responsible for the off-odor. In this study, we designed a simple quantification method for 3-MND in SBO, and evaluated the relationship between the 3-MND concentration and the intensity of the off-odor. 3-MND was analyzed by GC/MS with a thermal desorption unit system. By our method, the 3-MND concentration was found to increase with storage days and the SBO content under light exposure, and there was a high correlation between the measured 3-MND concentration and the intensity of the light-induced off-odor in SBO (R = 0.9586).

Rotational Seismology: AGU Session, Working Group, and Website

Science.gov (United States)

Lee, William H.K.; Igel, Heiner; Todorovska, Maria I.; Evans, John R.

2007-01-01

. Igel, W.H.K. Lee, and M. Todorovska during the 2006 AGU Fall Meeting. The goal of this session was to discuss rotational sensors, observations, modeling, theoretical aspects, and potential applications of rotational ground motions. The session was accompanied by the inauguration of an International Working Group on Rotational Seismology (IWGoRS) which aims to promote investigations of all aspects of rotational motions in seismology and their implications for related fields such as earthquake engineering, geodesy, strong-motion seismology, and tectonics, as well as to share experience, data, software, and results in an open Web-based environment. The primary goal of this article is to make the Earth Science Community aware of the emergence of the field of rotational seismology.

The Pleasures of Mud : Estonian Summer Resort Architecture / Mart Kalm

Index Scriptorium Estoniae

Kalm, Mart, 1961-

2006-01-01

Pärnu, Haapsalu, Kuressaare ja Narva-Jõesuu suvitusarhitektuurist 20. saj. esimesest poolest kuni 21. saj. alguseni. Arhitektide Olev Siinmaa, Anton Soansi, August Volbergi, Tõnis Mihkelsoni, Raivo Puusepa, Raivo Kotovi, Üla Koppeli, Andrus Kõresaare, ehitusinseneride Erich Ottingi ja Robert Ederma ning sisearhitektide Tüüne-Kristin Vaikla, Urmo Vaikla, Liisi Murula ja Raili Palingu loomingust

Kolmas mask : Eesti kutselise teatri sünniloo käsitlused tänapäeva lavadel / Veiko Märka

Index Scriptorium Estoniae

Märka, Veiko, 1964-

2006-01-01

Veiko Märka, Katri Aaslav-Tepandi, Raivo Adlas, Andrus Kivirähk, Jaanus Rohumaa ja Ilmar Raag teevad kokkuvõtteid Eesti kutselise teatri sünniloo käsitlustest nii teatris kui kinos. Vaatluse all on lavastused : Ilmar Külveti "Menning" Vanemuises (1990) Raivo Adlase lavastuses, Jaanus Rohumaa/Mari Tuulingu "Ainus ja igavene elu" Tallinna Linnateatris (1996) Jaanus Rohumaa lavastuses, "Udumäe kuningas" Palamuse harrastusteatris (2003), autor ja lavastaja Raivo Adlas, Andrus Kivirähki "Adolf Rühka lühikene elu" Eesti Draamateatris (2005) Ingomar Vihmari lavastuses ja "Libahundi needus" (ETV ja Shop of Dreams, 2005), režissöör Rainer Sarnet, stsenaristid Ilmar Raag, Margus Kasterpalu, Rainer Sarnet

The current perception threshold test differentiates categories of mechanical neck disorder.

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Uddin, Zakir; MacDermid, Joy C; Galea, Victoria; Gross, Anita R; Pierrynowski, Michael R

2014-07-01

Cross-sectional discriminative analysis. To determine whether current perception threshold (CPT) can differentiate between categories of patients with mechanical neck disorders (MNDs). Neck pain is the third most common musculoskeletal disorder and affects a third of all adults each year. It can present as neck pain without musculoskeletal signs, neck pain with musculoskeletal signs but no neurological signs, or neck pain with neurological signs. CPT testing can assess altered sensory perception that may reflect neurological changes. Patients with MNDs (n = 106) were classified into 3 groups, based on a standardized musculoskeletal examination process performed by an experienced physiotherapist who was blinded to CPT scores. The 3 groups were defined as neck pain without musculoskeletal signs (MND I) (n = 60), neck pain with musculoskeletal signs (MND II) (n = 29), and neck pain with neurological signs (MND III) (n = 17). A rapid protocol of CPT testing was performed at 3 frequencies (5, 250, and 2000 Hz), using 3 dermatomal locations on the hand. A 1-way analysis of variance with post hoc comparison and effect sizes was calculated to compare the mean CPT scores between the groups. A binary logistic-regression model was used to predict probability of higher CPT in MND III and to create a receiver-operating-characteristic curve. Mean CPT differed significantly across the 3 MND groups (MND I, 9.7; MND II, 10.6; and MND III, 11.8; Pabnormal CPT in MND III had an estimated 73% sensitivity and 81% specificity; the odds ratio was 11.5 (P = .001) for the differentiation capacity of CPT between MND II and III, with a cutoff of 11. The area under the receiver-operating-characteristic curve was 0.84 (95% confidence interval: 0.72, 0.96; P<.001). CPT testing has moderate discriminatory accuracy, specificity, and sensitivity for classification of MND categories into neck pain with or without neurological signs. J Orthop Sports Phys Ther 2014;44(7):532-540. Epub 10 May 2014

Two Studies on Twitter Networks and Tweet Content in Relation to Amyotrophic Lateral Sclerosis (ALS): Conversation, Information, and 'Diary of a Daily Life'.

Science.gov (United States)

Hemsley, Bronwyn; Palmer, Stuart

2016-01-01

To date, there is no research examining how adults with Amyotrophic Lateral Sclerosis (ALS) or Motor Neurone Disease (MND) and severe communication disability use Twitter, nor the use of Twitter in relation to ALS/MND beyond its use for fundraising and raising awareness. In this paper we (a) outline a rationale for the use of Twitter as a method of communication and information exchange for adults with ALS/MND, (b) detail multiple qualitative and quantitative methods used to analyse Twitter networks and tweet content in the our studies, and (c) present the results of two studies designed to provide insights on the use of Twitter by an adult with ALS/MND and by #ALS and #MND hashtag communities in Twitter. We will also discuss findings across the studies, implications for health service providers in Twitter, and directions for future Twitter research in relation to ALS/MND.

A Dutch family with autosomal recessively inherited lower motor neuron predominant motor neuron disease due to optineurin mutations

NARCIS (Netherlands)

Beeldman, Emma; van der Kooi, Anneke J.; de Visser, Marianne; van Maarle, Merel C.; van Ruissen, Fred; Baas, Frank

2015-01-01

Approximately 10% of motor neuron disease (MND) patients report a familial predisposition for MND. Autosomal recessively inherited MND is less common and is most often caused by mutations in the superoxide dismutase 1 (SOD1) gene. In 2010, autosomal recessively inherited mutations in the optineurin

The assessment of minor neurological dysfunction in infancy using the Touwen Infant Neurological Examination : strengths and limitations

NARCIS (Netherlands)

Hadders-Algra, Mijna; Heineman, Kirsten R.; Bos, Arend F.; Middelburg, Karin J.

Aim Little is known of minor neurological dysfunction (MND) in infancy. This study aimed to evaluate the inter-assessor reliability of the assessment of MND with the Touwen Infant Neurological Examination (TINE) and the construct and predictive validity of MND in infancy. Method Inter-assessor

Computational Analysis of Pharyngeal Swallowing Mechanics in Patients with Motor Neuron Disease: A Pilot Investigation.

Science.gov (United States)

Garand, K L; Schwertner, Ryan; Chen, Amy; Pearson, William G

2018-04-01

Swallowing impairment (dysphagia) is a common sequela in patients with motor neuron disease (MND). The purpose of this retrospective, observational pilot investigation was to characterize how pharyngeal swallowing mechanics are impacted in patients with MND using a comparison with healthy, non-dysphagic control group. Computational analysis of swallowing mechanics (CASM) was used to determine covariate biomechanics of pharyngeal swallowing from videofluoroscopic assessment in 15 patients with MND and 15 age- and sex-matched healthy controls. Canonical variant analysis with post hoc discriminate function analysis (DFA) was performed on coordinate data mapping functional muscle groups underlying pharyngeal swallowing. Differences in swallowing mechanics associated with group (MND; control), motor neuron predominance (upper; lower), onset (bulbar; spinal), and swallow task (thin, pudding) were evaluated and visualized. Pharyngeal swallowing mechanics differed significantly in patients with MND compared with healthy controls (D = 2.01, p mechanics by motor neuron predominance (D = 5.03, p mechanics of patients with MND differ from and are more heterogeneous than healthy controls. These findings suggest patients with MND may compensate reductions in pharyngeal shortening and tongue base retraction by extending the head and neck and increasing hyolaryngeal excursion. This work and further CASM investigations will lead to further insights into development and evaluation of targeted clinical treatments designed to prolong safe and efficient swallowing function in patients with MND.

WAIS Digit Span-Based Indicators of Malingered Neurocognitive Dysfunction: Classification Accuracy in Traumatic Brain Injury

Science.gov (United States)

Heinly, Matthew T.; Greve, Kevin W.; Bianchini, Kevin J.; Love, Jeffrey M.; Brennan, Adrianne

2005-01-01

The present study determined specificity and sensitivity to malingered neurocognitive dysfunction (MND) in traumatic brain injury (TBI) for several Wechsler Adult Intelligence Scale (WAIS) Digit Span scores. TBI patients (n = 344) were categorized into one of five groups: no incentive, incentive only, suspect, probable MND, and definite MND.…

Communications Technology and Motor Neuron Disease: An Australian Survey of People With Motor Neuron Disease.

Science.gov (United States)

Mackenzie, Lynette; Bhuta, Prarthna; Rusten, Kim; Devine, Janet; Love, Anna; Waterson, Penny

2016-01-25

People with Motor Neuron Disease (MND), of which amyotrophic lateral sclerosis (ALS) is the most common form in adults, typically experience difficulties with communication and disabilities associated with movement. Assistive technology is essential to facilitate everyday activities, promote social support and enhance quality of life. This study aimed to explore the types of mainstream and commonly available communication technology used by people with MND including software and hardware, to identify the levels of confidence and skill that people with MND reported in using technology, to determine perceived barriers to the use of technology for communication, and to investigate the willingness of people with MND to adopt alternative modes of communication. An on-line survey was distributed to members of the New South Wales Motor Neuron Disease Association (MND NSW). Descriptive techniques were used to summarize frequencies of responses and cross tabulate data. Free-text responses to survey items and verbal comments from participants who chose to undertake the survey by telephone were analyzed using thematic analysis. Responses from 79 MND NSW members indicated that 15-21% had difficulty with speaking, writing and/or using a keyboard. Commonly used devices were desktop computers, laptops, tablets and mobile phones. Most participants (84%) were connected to the Internet and used it for email (91%), to find out more about MND (59%), to follow the news (50%) or for on-line shopping (46%). A third of respondents used Skype or its equivalent, but few used this to interact with health professionals. People with MND need greater awareness of technology options to access the most appropriate solutions. The timing for people with MND to make decisions about technology is critical. Health professionals need skills and knowledge about the application of technology to be able to work with people with MND to select the best communication technology options as early as possible

MINOR NEUROLOGICAL DYSFUNCTION AFTER THE ONSET OF PUBERTY - ASSOCIATION WITH PERINATAL EVENTS

NARCIS (Netherlands)

SOORANILUNSING, RJ; HADDERSALGRA, M; HUISJES, HJ; TOUWEN, BCL

In order to study the hypotheses that puberty is related to a decrease of minor neurological dysfunction (MND) and that persisting MND is associated with perinatal factors, two groups (174 normal, 172 MND) of the Groningen Perinatal Project were followed from 12 to 14 years. At 14 years almost all

Multiple nuclear dots and rim-like/membranous IgG isotypes in primary biliary cirrhosis.

Science.gov (United States)

Muratori, Paolo; Granito, Alessandro; Ferri, Silvia; Pappas, Georgios; Volta, Umberto; Menichella, Rita; Bianchi, Francesco B; Lenzi, Marco; Muratori, Luigi

2009-03-01

Anti nuclear (ANA) immunomorphological patterns such as multiple nuclear dots (MND) and rim-like/membranous (RL/M) are considered highly specific but little sensitive for primary biliary cirrhosis (PBC) diagnosis. To evaluate frequency and clinical significance of MND and RL/M in PBC patients when investigated at the level of immunoglobulin G isotypes. MND and RL/M pattern have been tested in 141 PBC sera and 230 pathological controls using HEp-2 cells as substrate and anti- total IgG and individual IgG subclasses (IgG1, IgG2, IgG3, IgG4) as specific antisera. One hundred and fourteen of 141 (80%) PBC patients had RL/M or MND pattern when IgG subclasses were used as revealing reagents (vs. 34% when anti total IgG were used, p < 0.0001). The prevalent isotype was IgG1 for RL/M, and IgG2 for MND pattern. None of controls was positive. No clinical differences in terms of severity and outcome of disease have been observed in PBC patients positive for MND and RL/M when investigated with IgG isotypes. The research for RL/M and MND pattern at level of IgG isotype determines a wide gain in terms of sensitivity without a loss of specificity. In Italian PBC patients MND and RL/M pattern did not seem to characterize any subgroup of patients with a poorer prognosis.

Trends in motor neuron disease: association with latitude and air lead levels in Spain.

Science.gov (United States)

Santurtún, Ana; Villar, Alejandro; Delgado-Alvarado, Manuel; Riancho, Javier

2016-08-01

Motor neuron diseases (MND) are a group of disorders characterized by motor neuron degeneration. Among them, amyotrophic lateral sclerosis (ALS) is by far the most common in adulthood. This paper assesses the trend and geographical pattern in MND incidence in Spain and the possible air lead levels effect on this pathology. To confirm this concept, we performed a retrospective analysis of the deaths due to MND in Spain during 2000 and 2013, determined the geographical differences, and explored the relationship between MND and the air levels of lead. Overall, between 2000 and 2013, 11,355 people died in Spain because of MND. Disease mortality significantly increased in recent years (2007-2013) when compared with the first time of the period. Spearman's rank correlation coefficient also showed a statistically significant positive trend (CC = 0.824, p = 0.0002). Among people over 65 years, mortality rates were higher in Northern provinces. Moreover, we found a significant association of MND mortality with higher air lead levels (CC = 0.457, p = 0.01). Our study confirms that MND mortality is increasing in Spain, with a significant latitude gradient, which suggests an important role of environmental exposures. This ecological study suggests that air lead levels may be implicated in ALS pathogenesis.

Hematological Parameters and the State of Liver Cells of Rats After Oral Administration of Aflatoxin B1 Alone and Together with Nanodiamonds

Directory of Open Access Journals (Sweden)

Baron AV

2010-01-01

Full Text Available Abstract Hematological parameters and the state of liver cells of rats were examined in vivo after the animals received aflatoxin B1 (AfB1 alone and together with modified nanodiamonds (MND synthesized by detonation. The rats that had received the MND hydrosol had elevated leukocyte levels, mainly due to higher granulocyte counts and somewhat increased monocyte counts compared to control rats. Hematological parameters of the rats that had received AfB1 alone differed from those of the control rats in another way: total white blood cell counts were significantly lower due to the decreased lymphocyte counts. In rats that had consumed AfB1 with the MND hydrosol, changes in hematological parameters were less pronounced than in rats that had consumed either AfB1 or MND. Electron microscopy showed that hepatocytes of the rats that had received the MND hydrosol or AfB1 with the MND hydrosol contained elevated levels of lipid inclusions and lysosomes. Hyperplasia of the smooth endoplasmic reticulum (EPR was revealed in liver specimens of the rats that had received AfB1. Results of the study suggest the conclusion about mutual mitigation of the effects of nanoparticles and the mycotoxin on rats blood and liver cells after AfB1 has adsorbed on MND.

Motor Neurone Disease: Disability Profile and Service Needs in an Australian Cohort

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Ng, Louisa; Talman, Paul; Khan, Fary

2011-01-01

Motor neurone disease (MND) places considerable burden upon patients and caregivers. This is the first study, which describes the disability profile and healthcare needs for persons with MND (pwMND) in an Australian sample from the perspective of the patients and caregivers to identify current gaps in the knowledge and service provision. A…

Effect of Furan Fatty Acids and 3-Methyl-2,4-nonanedione on Light-Induced Off-Odor in Soybean Oil.

Science.gov (United States)

Sano, Takashi; Okabe, Ryo; Iwahashi, Maiko; Imagi, Jun; Sato, Toshiro; Yamashita, Toshiyuki; Fukusaki, Eiichiro; Bamba, Takeshi

2017-03-15

Soybean oil is one of the most widely consumed vegetable oils. However, under photooxidative conditions, this oil develops a beany and green off-odor through a mechanism that has not yet been elucidated. Upon photooxidation, 3-methyl-2,4-nonanedione (3-MND) produces a strong aroma. In this study, the effect of furan fatty acids and 3-MND on odor reversion in soybean oil was investigated. Our findings suggest that the observed light-induced off-odor was likely attributable to the furan fatty acids present in the oil through the generation of 3-MND. While 3-MND may not be directly responsible for the development of light-induced off-odor, this compound appears to be involved because off-odor was detected in canola oil samples containing added 3-MND. In addition, in the present work, 3-hydroxy-3-methyl-2,4-nonanedione, which is derived from 3-MND, was identified for the first time in light-exposed soybean oil and shown to be one of the compounds responsible for odor reversion.

Cerebrospinal fluid neurofilament light concentration in motor neuron disease and frontotemporal dementia predicts survival.

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Skillbäck, Tobias; Mattsson, Niklas; Blennow, Kaj; Zetterberg, Henrik

2017-08-01

To aid diagnostics, patient stratification and studies seeking to find treatments for the related diseases motor neuron disease (MND) and frontotemporal dementia (FTD), there is a need to establish a way to assess disease severity and the amount of ongoing neurodegeneration. Previous studies have suggested that cerebrospinal fluid (CSF) neurofilament light (NFL) may serve this purpose. We cross-referenced the Swedish mortality registry with the laboratory database at Sahlgrenska University Hospital to produce a dataset of CSF NFL concentrations and mortality information for 715 MND patients, 87 FTD patients, and 107 healthy controls. Biomarker concentrations were analysed in relation to recorded cause of death and time of death. MND patients had significantly higher CSF NFL concentrations than FTD patients. Both groups had significantly higher concentrations than the healthy controls (mean 709% increase in MND and 307% increase in FTD). Higher concentrations of CSF NFL were associated with shorter survival in both MND and FTD. The results of this study strengthen the notion of CSF NFL as a useful tool for determining disease intensity in MND and FTD patients. Further studies in patient cohorts with clinically subtyped and genetically classified diagnoses are needed.

Genetic epidemiology of motor neuron disease-associated variants in the Scottish population.

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Black, Holly A; Leighton, Danielle J; Cleary, Elaine M; Rose, Elaine; Stephenson, Laura; Colville, Shuna; Ross, David; Warner, Jon; Porteous, Mary; Gorrie, George H; Swingler, Robert; Goldstein, David; Harms, Matthew B; Connick, Peter; Pal, Suvankar; Aitman, Timothy J; Chandran, Siddharthan

2017-03-01

Genetic understanding of motor neuron disease (MND) has evolved greatly in the past 10 years, including the recent identification of association between MND and variants in TBK1 and NEK1. Our aim was to determine the frequency of pathogenic variants in known MND genes and to assess whether variants in TBK1 and NEK1 contribute to the burden of MND in the Scottish population. SOD1, TARDBP, OPTN, TBK1, and NEK1 were sequenced in 441 cases and 400 controls. In addition to 44 cases known to carry a C9orf72 hexanucleotide repeat expansion, we identified 31 cases and 2 controls that carried a loss-of-function or pathogenic variant. Loss-of-function variants were found in TBK1 in 3 cases and no controls and, separately, in NEK1 in 3 cases and no controls. This study provides an accurate description of the genetic epidemiology of MND in Scotland and provides support for the contribution of both TBK1 and NEK1 to MND susceptibility in the Scottish population. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Mn-doped near-infrared quantum dots as multimodal targeted probes for pancreatic cancer imaging

Science.gov (United States)

Yong, Ken-Tye

2009-01-01

This work presents a novel approach to producing manganese (Mn)-doped quantum dots (Mnd-QDs) emitting in the near-infrared (NIR). Surface functionalization of Mnd-QDs with lysine makes them stably disperse in aqueous media and able to conjugate with targeting molecules. The nanoparticles were structurally and compositionally characterized and maintained a high photoluminescence quantum yield and displayed paramagnetism in water. The receptor-mediated delivery of bioconjugated Mnd-QDs into pancreatic cancer cells was demonstrated using the confocal microscopy technique. Cytotoxicity of Mnd-QDs on live cells has been evaluated. The NIR-emitting characteristic of the QDs has been exploited to acquire whole animal body imaging with high contrast signals. In addition, histological and blood analysis of mice have revealed that no long-term toxic effects arise from MnD-QDs. These studies suggest multimodal Mnd-QDs have the potentials as probes for early pancreatic cancer imaging and detection.

Patterns of Weakness, Classification of Motor Neuron Disease, and Clinical Diagnosis of Sporadic Amyotrophic Lateral Sclerosis.

Science.gov (United States)

Statland, Jeffrey M; Barohn, Richard J; McVey, April L; Katz, Jonathan S; Dimachkie, Mazen M

2015-11-01

When approaching a patient with suspected motor neuron disease (MND), the pattern of weakness on examination helps distinguish MND from other diseases of peripheral nerves, the neuromuscular junction, or muscle. MND is a clinical diagnosis supported by findings on electrodiagnostic testing. MNDs exist on a spectrum, from a pure lower motor neuron to mixed upper and lower motor neuron to a pure upper motor neuron variant. Amyotrophic lateral sclerosis (ALS) is a progressive mixed upper and lower motor neuron disorder, most commonly sporadic, which is invariably fatal. This article describes a pattern approach to identifying MND and clinical features of sporadic ALS. Copyright © 2015 Elsevier Inc. All rights reserved.

Racial differences in motor neuron disease.

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Gundogdu, Betul; Al-Lahham, Tawfiq; Kadlubar, Fred; Spencer, Horace; Rudnicki, Stacy A

2014-03-01

Our objective was to compare and contrast clinical features of black and white patients seen in the UAMS ALS/Motor Neuron Disease (MND) clinic from January 2001 to December 2010. Death certificate information was reviewed to determine race of Arkansans who died of ALS/MND between 1999 and 2006. We used a retrospective chart review of patients with ALS/MND seen at least once in our clinic and reviewed state death certificate data. Results showed that from 1999 to 2006, 466 Arkansas deaths were attributed (immediate or contributory) to ALS/MND; 17 (3.6%) were black, four (0.9%) other, and 445 (95.5%) white. During this period, the proportion of black Arkansans was 17%. From 2001 to 2010, we saw 330 patients with ALS/MND: 30 (9.1%) black, six (1.8%) other, 294 (89.1%) white. Average onset age for whites was 58.1 + 12.4 years, for blacks 52.8 + 13.0 (p = 0.038). Gender, onset site, time from symptom onset to first clinic visit and initial vital capacity were similar between the groups. Initial ALSFRS-R was 37.5 + 7.2 for whites and 30.8 + 8.5 (p = 0.004) for blacks. A first or second degree relative with ALS/MND was reported by 8.1% of whites and by none of the black patients (p = 0.15). Riluzole, PEG and non-invasive ventilation use was similar between the groups. Median tracheostomy-free survival was 36 months for white and 40 months for black patients (p = 0.475). In conclusion, although blacks appear relatively spared from ALS/MND, they present at an earlier age and are functionally worse at their first visit. Investigating the genetic make-up of blacks with the disease may help identify genes that modify risk of developing ALS/MND.

Racial differences in motor neuron disease

Science.gov (United States)

GUNDOGDU, BETUL; AL-LAHHAM, TAWFIQ; SPENCER, HORACE; RUDNICKI, STACY A.

2014-01-01

Our objective was to compare and contrast clinical features of black and white patients seen in the UAMS ALS/Motor Neuron Disease (MND) clinic from January 2001 to December 2010. Death certificate information was reviewed to determine race of Arkansans who died of ALS/MND between 1999 and 2006. We used a retrospective chart review of patients with ALS/MND seen at least once in our clinic and reviewed state death certificate data. Results showed that from 1999 to 2006, 466 Arkansas deaths were attributed (immediate or contributory) to ALS/MND; 17 (3.6%) were black, four (0.9%) other, and 445 (95.5%) white. During this period, the proportion of black Arkansans was 17%. From 2001 to 2010, we saw 330 patients with ALS/MND: 30 (9.1%) black, six (1.8%) other, 294 (89.1%) white. Average onset age for whites was 58.1 ± 12.4 years, for blacks 52.8 ± 13.0 (p = 0.038). Gender, onset site, time from symptom onset to first clinic visit and initial vital capacity were similar between the groups. Initial ALSFRS-R was 37.5 ± 7.2 for whites and 30.8 ± 8.5 (p = 0.004) for blacks. A first or second degree relative with ALS/MND was reported by 8.1% of whites and by none of the black patients (p = 0.15). Riluzole, PEG and non-invasive ventilation use was similar between the groups. Median tracheostomy-free survival was 36 months for white and 40 months for black patients (p = 0.475). In conclusion, although blacks appear relatively spared from ALS/MND, they present at an earlier age and are functionally worse at their first visit. Investigating the genetic make-up of blacks with the disease may help identify genes that modify risk of developing ALS/MND. PMID:24067242

A Temporal Association between Accumulated Petrol (Gasoline Lead Emissions and Motor Neuron Disease in Australia

Directory of Open Access Journals (Sweden)

Mark A. S. Laidlaw

2015-12-01

Full Text Available Background: The age standardised death rate from motor neuron disease (MND has increased from 1.29 to 2.74 per 100,000, an increase of 112.4% between 1959 and 2013. It is clear that genetics could not have played a causal role in the increased rate of MND deaths over such a short time span. We postulate that environmental factors are responsible for this rate increase. We focus on lead additives in Australian petrol as a possible contributing environmental factor. Methods: The associations between historical petrol lead emissions and MND death trends in Australia between 1962 and 2013 were examined using linear regressions. Results: Regression results indicate best fit correlations between a 20 year lag of petrol lead emissions and age-standardised female death rate (R2 = 0.86, p = 4.88 × 10−23, male age standardised death rate (R2 = 0.86, p = 9.4 × 10−23 and percent all cause death attributed to MND (R2 = 0.98, p = 2.6 × 10−44. Conclusion: Legacy petrol lead emissions are associated with increased MND death trends in Australia. Further examination of the 20 year lag between exposure to petrol lead and the onset of MND is warranted.

[Removal Kinetics and Mechanism of Aniline by Manganese-oxide-modified Diatomite].

Science.gov (United States)

Xiao, Shao-dan; Liu, Lu; Jiang, Li-ying; Chen, Jian-meng

2015-06-01

A novel rapid green one-step method was developed for the preparation of manganese modified diatomite (Mn-D) by treating roasted diatomite with an acidic permanganate solution. The effects of calcination temperature and mass ratio of KMnO4 and diatomite (p) on aniline removal efficiency of Mn-D were investigated. The removal kinetics and mechanism of aniline by Mn-D were also discussed. The results showed that when the optimal calcination temperature was 450 degrees C, p was 1.6, and the loading amounts of δ-MnO2 was 0.82 g x g(-1), Mn-D had a great performance for aniline removal, and more than 80% of aniline was adsorbed within 10 minutes, accompanied with the release of Mn2+. In acidic conditions, the adsorption process on Mn-D followed pseudo-second-order and was mainly controlled by intra-particle diffusion. The best fitting of the experimental adsorption data was given by the Freundlich equation. Gas chromatograph-mass spectrometer was applied to identify the reaction intermediates at different times, and azobenzene was found to be the main reaction intermediate in the degradation system. Based on the above observations, the possible degradation pathway of aniline by Mn-D was proposed.

"Matsi leivamärss" : elamukvartal Papli tänaval Pärnus = Papli St. Residential Area in Pärnu / Karri Tiigisoon

Index Scriptorium Estoniae

Tiigisoon, Karri

2004-01-01

Ka hotell-veekeskusest "Tervise Paradiis", parklast, AB Luhse & Tuhal poolt koostatud ja 2000. a. kehtestatud Side t., A. H. Tammsaare pst., Mai t. elamurajooni ja merekalda vahelise ala detailplaneeringust. 2003.-2004. aastatel valminud Papli t. kahekorruselised korterelamud projekteerisid arhitektid Raivo Puusepp (Papli t. 32, AB Raivo Puusepp), Kalle Vellevoog (Papli t. 34, AB JVR), Tanel Tuhal ja Ra Luhse (Papli t. 20, 22, 24, 26, 28, 30, AB Luhse & Tuhal). Ill.: 4 plaani, 8 värv. välisvaadet

Feasibility, acceptability, and potential effectiveness of dignity therapy for people with motor neurone disease.

Directory of Open Access Journals (Sweden)

Brenda Bentley

Full Text Available BACKGROUND: Motor neurone disease (MND practice guidelines suggest developing interventions that will promote hope, meaning, and dignity to alleviate psychological distress, but very little research has been done. This study begins to address this need by exploring the use of dignity therapy with people with MND. Dignity therapy is a brief psychotherapy that promotes hope, meaning and dignity, and enhances the end of life for people with advanced cancer. The aims of this study are to assess the feasibility, acceptability, and potential effectiveness of dignity therapy for people with MND. METHODS/DESIGN: This cross-sectional feasibility study used a one-group pre-test post-test design with 29 people diagnosed with MND. Study participants completed the following self-report questionnaires: Herth Hope Index, FACIT-sp, Patient Dignity Inventory, ALS Assessment Questionnaire, ALS Cognitive Behavioural Screen, and a demographic and health history questionnaire. Acceptability was measured with a 25-item feedback questionnaire. Feasibility was assessed by examining the length of time taken to complete dignity therapy and how symptoms common in MND affected the intervention. Generalised linear mixed models and reliable change scores were used to analyse the data. RESULTS: There were no significant pre-test post-test changes for hopefulness, spirituality or dignity on the group level, but there were changes in hopefulness on the individual level. The results of the feedback questionnaire indicates dignity therapy is highly acceptable to people with MND, who report benefits similar to those in the international randomised controlled trial on dignity therapy, a population who primarily had end-stage cancer. Benefits include better family relationships, improved sense of self and greater acceptance. Dignity therapy with people with MND is feasible if the therapist can overcome time and communication difficulties. CONCLUSIONS: Dignity therapy for people with

The Effectiveness of Prophylactic Modified Neck Dissection for Reducing the Development of Lymph Node Recurrence of Papillary Thyroid Carcinoma.

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Ito, Yasuhiro; Miyauchi, Akira; Kudo, Takumi; Kihara, Minoru; Fukushima, Mitsuhiro; Miya, Akihiro

2017-09-01

The most frequent recurrence site of papillary thyroid carcinoma (PTC) is the cervical lymph nodes. The introduction of an electric linear probe for use with ultrasonography in 1996 improved preoperative lateral neck evaluations. Before 2006, however, our hospital routinely performed prophylactic modified neck dissection (p-MND) for N0 or N1a PTCs >1 cm to prevent node recurrence. In 2006, we changed our policy and the indications for p-MND to PTCs >3 cm and/or with significant extrathyroid extension. Here, we retrospectively compared lymph node recurrence-free survival between PTCs with/without p-MND. We examined the cases of N0 or N1 and M0 PTC patients who underwent initial surgery in 1992-2012. To compare lymph node recurrence-free survival between patients who did/did not undergo p-MND, we divided these patients into three groups (excluding those whose surgery was in 2006): the 2045 patients whose surgery was performed in 1992-1996 (Group 1), the 2989 with surgery between 1997 (post-introduction of ultrasound electric linear probes) and 2005 (Group 2), and the 5332 operated on in 2007-2012 (Group 3). The p-MND performance rate of Group 3 (9%) was much lower than that of Group 1 (80%), but the lymph node recurrence-free survival of the former was significantly better, probably due to differences in clinical features and neck evaluations by ultrasound between the two groups. Our analysis of the patients aged Abolishing routine p-MND for PTCs in 2006 did not decrease lymph node recurrence-free survival, probably due to improved ultrasound preoperative neck evaluations and clinical feature changes. Selective p-MND for high-risk cases improved lymph node recurrence-free survival.

The TiM system: developing a novel telehealth service to improve access to specialist care in motor neurone disease using user-centered design.

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Hobson, Esther V; Baird, Wendy O; Partridge, Rebecca; Cooper, Cindy L; Mawson, Susan; Quinn, Ann; Shaw, Pamela J; Walsh, Theresa; Wolstenholme, Daniel; Mcdermott, Christopher J

2018-08-01

Attendance at a specialist multidisciplinary motor neurone disease (MND) clinic is associated with improved survival and may also improve quality of life and reduce hospital admissions. However, patients struggle to travel to clinic and may experience difficulties between clinic visits that may not be addressed in a timely manner. We wanted to explore how we could improve access to specialist MND care. We adopted an iterative, user-centered co-design approach, collaborating with those with experience of providing and receiving MND care including patients, carers, clinicians, and technology developers. We explored the unmet needs of those living with MND, how they might be met through service redesign and through the use of digital technologies. We developed a new digital solution and performed initial testing with potential users including clinicians, patients, and carers. We used these findings to develop a telehealth system (TiM) using an Android app into which patients and carers answer a series of questions about their condition on a weekly basis. The questions aim to capture all the physical, emotional, and social difficulties associated with MND. This information is immediately uploaded to the internet for review by the MND team. The data undergoes analysis in order to alert clinicians to any changes in a patient or carer's condition. We describe the benefits of developing a novel digitally enabled service underpinned by participatory design. Future trials must evaluate the feasibility and acceptability of the TiM system within a clinical environment.

Myonuclear domain size and myosin isoform expression in muscle fibres from mammals representing a 100,000-fold difference in body size.

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Liu, Jing-Xia; Höglund, Anna-Stina; Karlsson, Patrick; Lindblad, Joakim; Qaisar, Rizwan; Aare, Sudhakar; Bengtsson, Ewert; Larsson, Lars

2009-01-01

This comparative study of myonuclear domain (MND) size in mammalian species representing a 100,000-fold difference in body mass, ranging from 25 g to 2500 kg, was undertaken to improve our understanding of myonuclear organization in skeletal muscle fibres. Myonuclear domain size was calculated from three-dimensional reconstructions in a total of 235 single muscle fibre segments at a fixed sarcomere length. Irrespective of species, the largest MND size was observed in muscle fibres expressing fast myosin heavy chain (MyHC) isoforms, but in the two smallest mammalian species studied (mouse and rat), MND size was not larger in the fast-twitch fibres expressing the IIA MyHC isofom than in the slow-twitch type I fibres. In the larger mammals, the type I fibres always had the smallest average MND size, but contrary to mouse and rat muscles, type IIA fibres had lower mitochondrial enzyme activities than type I fibres. Myonuclear domain size was highly dependent on body mass in the two muscle fibre types expressed in all species, i.e. types I and IIA. Myonuclear domain size increased in muscle fibres expressing both the beta/slow (type I; r = 0.84, P fast IIA MyHC isoform (r = 0.90; P muscle fibre type, independent of species. However, myosin isoform expression is not the sole protein determining MND size, and other protein systems, such as mitochondrial proteins, may be equally or more important determinants of MND size.

Exploring the Role of PGC-1α in Defining Nuclear Organisation in Skeletal Muscle Fibres.

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Ross, Jacob A; Pearson, Adam; Levy, Yotam; Cardel, Bettina; Handschin, Christoph; Ochala, Julien

2017-06-01

Muscle fibres are multinucleated cells, with each nucleus controlling the protein synthesis in a finite volume of cytoplasm termed the myonuclear domain (MND). What determines MND size remains unclear. In the present study, we aimed to test the hypothesis that the level of expression of the transcriptional coactivator PGC-1α and subsequent activation of the mitochondrial biogenesis are major contributors. Hence, we used two transgenic mouse models with varying expression of PGC-1α in skeletal muscles. We isolated myofibres from the fast twitch extensor digitorum longus (EDL) and slow twitch diaphragm muscles. We then membrane-permeabilised them and analysed the 3D spatial arrangements of myonuclei. In EDL muscles, when PGC-1α is over-expressed, MND volume decreases; whereas, when PGC-1α is lacking, no change occurs. In the diaphragm, no clear difference was noted. This indicates that PGC-1α and the related mitochondrial biogenesis programme are determinants of MND size. PGC-1α may facilitate the addition of new myonuclei in order to reach MND volumes that can support an increased mitochondrial density. J. Cell. Physiol. 232: 1270-1274, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Sorption of Cr(III) ion from aqueous solution by two kinds of modified diatomite.

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Li, Er; Zeng, Xiangying

2012-01-01

Raw diatomite modified by microemulsion (DMM) and manganese oxide (MnD) were used for the removal of Cr(III) ions from aqueous solution. The characteristics and performance of these two types of modified diatomite on Cr(III) ion adsorption were compared. The results indicate that the Cr(III) ion adsorption capacities of diatomite were considerably improved after modifications by manganese oxide (MnO) and microemulsion. The surface area of MnD was increased because of the formation of MnO on the diatomite surface, and that of DMM was promoted owing to the existence of the hydrolyzed aromatic acid. Because of the stronger surface ionized function, the adsorption performance of Cr(III) ions in DMM was better than that in MnD. Within the experimental range of pH (i.e. 2.2-6.3), the Cr(III) ion removal of DMM (35-70%) was higher than that of MnD (33-59%) owing to the different electrostatic forces between the Cr(III) ion and the surface of the modified diatomite. The Cr(III) ion removal in MnD and DMM was improved with the increase of synthetic solution concentration in volumes from 0 to 2,500 mL.

TDP-43 pathology in familial frontotemporal dementia and motor neuron disease without Progranulin mutations.

NARCIS (Netherlands)

Seelaar, H.; Schelhaas, H.J.; Azmani, A.; Kusters, B.; Rosso, S.; Majoor-Krakauer, D.F.; Rijik, M.C. de; Rizzu, P.; Brummelhuis, M. Ten; Doorn, P.A. van; Kamphorst, W.; Willemsen, R.; Swieten, J. van

2007-01-01

Frontotemporal dementia is accompanied by motor neuron disease (FTD + MND) in approximately 10% of cases. There is accumulating evidence for a clinicopathological overlap between FTD and MND based on observations of familial aggregation and neuropathological findings of ubiquitin-positive neuronal

TDP-43 pathology in familial frontotemporal dementia and motor neuron disease without Progranulin mutations

NARCIS (Netherlands)

H. Seelaar (Harro); H. Jurgen Schelhaas; A. Azmani (Asma); B. Küsters (Benno); S.M. Rosso (Sonia); D.F. Majoor-Krakauer (Danielle); M.C. de Rijik (Maarten); P. Rizzu (Patrizia); M. ten Brummelhuis (Ming); P.A. van Doorn (Pieter); W. Kamphorst (Wouter); R. Willemsen (Rob); J.C. van Swieten (John)

2007-01-01

textabstractFrontotemporal dementia is accompanied by motor neuron disease (FTD + MND) in ∼10% of cases. There is accumulating evidence for a clinicopathological overlap between FTD and MND based on observations of familial aggregation and neuropathological findings of ubiquitin-positive neuronal

Is dignity therapy feasible to enhance the end of life experience for people with motor neurone disease and their family carers?

Directory of Open Access Journals (Sweden)

Bentley Brenda

2012-09-01

Full Text Available Abstract Background Development of interventions that address psychosocial and existential distress in people with motor neurone disease (MND or that alleviate caregiver burden in MND family carers have often been suggested in the research literature. Dignity therapy, which was developed to reduce psychosocial and existential distress at the end of life, has been shown to benefit people dying of cancer and their families. These results may not be transferable to people with MND. The objectives of this study are to assess the feasibility, acceptability and potential effectiveness of dignity therapy to enhance the end of life experience for people with motor neurone disease and their family carers. Methods/design This is a cross-sectional study utilizing a single treatment group and a pre/post test design. The study population will comprise fifty people diagnosed with MND and their nominated family carers. Primarily quantitative outcomes will be gathered through measures assessed at baseline and at approximately one week after the intervention. Outcomes for participants include hopefulness, spirituality and dignity. Outcomes for family carers include perceived caregiver burden, hopefulness and anxiety/depression. Feedback and satisfaction with the intervention will be gathered through a questionnaire. Discussion This detailed research will explore if dignity therapy has the potential to enhance the end of life experience for people with MND and their family carers, and fill a gap for professionals who are called on to address the spiritual, existential and psychosocial needs of their MND patients and families. Trial registration ACTRN Trial Number: ACTRN12611000410954

Comparison of Performance of the VIP and WMT in a Criminal Forensic Sample.

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Fazio, Rachel L; Denney, Robert L

2018-01-24

To compare the efficacy of the Validity Indicator Profile (VIP) and Word Memory Test (WMT) in a criminal forensic population. Potential participants included 225 male evaluees from a maximum-security Federal prison referred for neuropsychological evaluation for either forensic purposes or for suspected neurocognitive dysfunction as part of a medical evaluation. Examinees were included in the analysis if administered the VIP (Verbal, Nonverbal, or both tests) and WMT along with at least two other freestanding PVTs; 74 satisfied these criteria. Participants were then categorized as having probable Malingered Neurocognitive Dysfunction (+MND) if they failed at least two freestanding validity indicators, negative for MND (-MND) if they passed all indicators, and Possible MND (pMND) if they failed one indicator. Groups were very demographically similar. There were significant differences in WMT scores and distribution of VIP profiles across groups. Whether using traditional or investigative cut scores, and whether using the WMT with or without consideration of a GMIP profile, the WMT demonstrated superior sensitivity and specificity on nearly every comparison. The VIP, when interpreted in the traditional fashion, and the WMT with GMIP, both had more than adequate psychometric properties when used with criminal forensic evaluees, strengthening the body of literature supporting their use for these types of evaluations. Counting a positive on either of the VIP subtests as an indication of +MND improves the psychometric properties of the VIP slightly, although the WMT had the better overall classification accuracy. © The Author(s) 2018. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Decision-making and referral processes for patients with motor neurone disease: a qualitative study of GP experiences and evaluation of a new decision-support tool.

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Baxter, Susan; McDermott, Christopher J

2017-05-08

The diagnosis of motor neurone disease (MND) is known to be challenging and there may be delay in patients receiving a correct diagnosis. This study investigated the referral process for patients who had been diagnosed with MND, and whether a newly-developed tool (The Red Flags checklist) might help General Practitioners (GPs) in making referral decisions. We carried out interviews with GPs who had recently referred a patient diagnosed with MND, and interviews/surveys with GPs who had not recently referred a patient with suspected MND. We collected data before the Red Flags checklist was introduced; and again one year later. We analysed the data to identify key recurring themes. Forty two GPs took part in the study. The presence of fasciculation was the clinical feature that most commonly led to consideration of a potential MND diagnosis. GPs perceived that their role was to make onward referrals rather than attempting to make a diagnosis, and delays in correct diagnosis tended to occur at the specialist level. A quarter of participants had some awareness of the newly-developed tool; most considered it useful, if incorporated into existing systems. While fasciculation is the most common symptom associated with MND, other bulbar, limb or respiratory features, together with progression should be considered. There is a need for further research into how decision-support tools should be designed and provided, in order to best assist GPs with referral decisions. There is also a need for further work at the level of secondary care, in order that referrals made are re-directed appropriately.

Record linkage between hospital discharges and mortality registries for motor neuron disease case ascertainment for the Spanish National Rare Diseases Registry.

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Ruiz, Elena; Ramalle-Gómara, Enrique; Quiñones, Carmen

2014-06-01

Our objective was to analyse the coverage of hospital discharge data and the mortality registry (MR) of La Rioja to ascertain motor neuron disease (MND) cases to be included in the Spanish National Rare Diseases Registry. MND cases that occurred in La Rioja during the period 1996-2011 were selected from hospital discharge data and the MR by means of the International Classification of Diseases. Review of the medical histories was carried out to confirm the causes of death reported. Characteristics of the population with MND were analysed. A total of 133 patients with MND were detected in La Rioja during the period 1996-2011; 30.1% were only recorded in the hospital discharges data, 12.0% only in the MR, and 57.9% were recorded by both databases. Medical records revealed a miscoding of patients who had been diagnosed with progressive supranuclear palsy but were recorded in the MR with an MND code. In conclusion, the hospital discharges data and the MR appear to be complementary and are valuable databases for the Spanish National Rare Diseases Registry when MNDs are properly codified. Nevertheless, it would be advisable to corroborate the validity of the MR as data source since the miscoding of progressive supranuclear palsy has been corrected.

Being Yourself and Thinking About the Future in People With Motor Neuron Disease: A Grounded Theory of Self-care Processes.

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Bassola, Barbara; Sansone, Valeria Ada; Lusignani, Maura

2018-06-01

Self-care is a crucial aspect in the management of people with motor neuron disease (MND). Nurses and healthcare professionals must know the processes used by patients in performing self-care to identify problems and help them. Decision-making processes, self-understanding, and political and social support influence the self-care process in chronic diseases. Little is known about the self-care process in MND. The aim of this study was to gain insight on the self-care processes in people with MND. A grounded theory method was chosen for this study. Data from interviews were gathered, and a simultaneous comparative analysis was conducted to identify categories and codes. Twenty-one people with spinal muscular atrophy and amyotrophic lateral sclerosis participated in the study. Five categories were identified as grounded in the data. The process starts from "being yourself in the care," and it develops thanks to "growing and changing" and with a "thinking about the future" approach. "Family role" and "you and who helps you" categories affect the process itself. The self-care process in people with MND is not seen in a daily perspective but changes with the evolution of the disease. For the growing patients with MND, changing, accepting and controlling the disease while deciding autonomously are the foundations of the process.

Interactions of Aging, Overload, and Creatine Supplementation in Rat Plantaris Muscle

Directory of Open Access Journals (Sweden)

Mark D. Schuenke

2011-01-01

Full Text Available Attenuation of age-related sarcopenia by creatine supplementation has been equivocal. In this study, plantaris muscles of young (Y; 5m and aging (A; 24m Fisher 344 rats underwent four weeks of either control (C, creatine supplementation (Cr, surgical overload (O, or overload plus creatine (OCr. Creatine alone had no effect on muscle fiber cross-sectional area (CSA or heat shock protein (HSP70 and increased myonuclear domain (MND only in young rats. Overload increased CSA and HSP70 content in I and IIA fibers, regardless of age, and MND in IIA fibers of YO rats. CSA and MND increased in all fast fibers of YOCr, and CSA increased in I and IIA fibers of AOCr. OCR did not alter HSP70, regardless of age. MND did not change in aging rats, regardless of treatment. These data indicate creatine alone had no significant effect. Creatine with overload produced no additional hypertrophy relative to overload alone and attenuated overload-induced HSP70 expression.

Structural and functional brain signatures of C9orf72 in motor neuron disease.

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Agosta, Federica; Ferraro, Pilar M; Riva, Nilo; Spinelli, Edoardo Gioele; Domi, Teuta; Carrera, Paola; Copetti, Massimiliano; Falzone, Yuri; Ferrari, Maurizio; Lunetta, Christian; Comi, Giancarlo; Falini, Andrea; Quattrini, Angelo; Filippi, Massimo

2017-09-01

This study investigated structural and functional magnetic resonance imaging abnormalities in hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9orf72) motor neuron disease (MND) relative to disease severity-matched sporadic MND cases. We enrolled 19 C9orf72 and 67 disease severity-matched sporadic MND patients, and 22 controls. Sporadic cases were grouped in patients with: no cognitive/behavioral deficits (sporadic-motor); same patterns of cognitive/behavioral impairment as C9orf72 cases (sporadic-cognitive); shorter disease duration versus other sporadic groups (sporadic-early). C9orf72 patients showed cerebellar and thalamic atrophy versus all sporadic cases. All MND patients showed motor, frontal, and temporoparietal cortical thinning and motor and extramotor white matter damage versus controls, independent of genotype and presence of cognitive impairment. Compared with sporadic-early, C9orf72 patients revealed an occipital cortical thinning. C9orf72 patients had enhanced visual network functional connectivity versus sporadic-motor and sporadic-early cases. Structural cerebellar and thalamic damage and posterior cortical alterations are the brain magnetic resonance imaging signatures of C9orf72 MND. Frontotemporal cortical and widespread white matter involvement are likely to be an effect of the disease evolution rather than a C9orf72 marker. Copyright © 2017 Elsevier Inc. All rights reserved.

The MY NASA DATA Project: Preparing Future Earth and Environmental Scientists, and Future Citizens

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Chambers, L. H.; Phelps, C. S.; Phipps, M.; Holzer, M.; Daugherty, P.; Poling, E.; Vanderlaan, S.; Oots, P. C.; Moore, S. W.; Diones, D. D.

2008-12-01

For the past 5 years, the MY NASA DATA (MND) project at NASA Langley has developed and adapted tools and materials aimed at enabling student access to real NASA Earth science satellite data. These include web visualization tools including Google Earth capabilities, but also GPS and graphing calculator exercises, Excel spreadsheet analyses, and more. The project team, NASA scientists, and over 80 classroom science teachers from around the country, have created over 85 lesson plans and science fair project ideas that demonstrate NASA satellite data use in the classroom. With over 150 Earth science parameters to choose from, the MND Live Access Server enables scientific inquiry on numerous interconnected Earth and environmental science topics about the Earth system. Teachers involved in the project report a number of benefits, including networking with other teachers nationwide who emphasize data collection and analysis in the classroom, as well as learning about other NASA resources and programs for educators. They also indicate that the MND website enhances the inquiry process and facilitates the formation of testable questions by students (a task that is typically difficult for students to do). MND makes science come alive for students because it allows them to develop their own questions using the same data scientists use. MND also provides educators with a rich venue for science practice skills, which are often overlooked in traditional curricula as teachers concentrate on state and national standards. A teacher in a disadvantaged school reports that her students are not exposed to many educational experiences outside the classroom. MND allows inner city students to be a part of NASA directly. They are able to use the same information that scientists are using and this gives them inspiration. In all classrooms, the MND microsets move students out of their local area to explore global data and then zoom back into their homes realizing that they are a part of the

Spatially complex distribution of dissolved manganese in a fjord as revealed by high-resolution in situ sensing using the autonomous underwater vehicle Autosub.

Science.gov (United States)

Statham, P J; Connelly, D P; German, C R; Brand, T; Overnell, J O; Bulukin, E; Millard, N; McPhail, S; Pebody, M; Perrett, J; Squire, M; Stevenson, P; Webb, A

2005-12-15

Loch Etive is a fjordic system on the west coast of Scotland. The deep waters of the upper basin are periodically isolated, and during these periods oxygen is lost through benthic respiration and concentrations of dissolved manganese increase. In April 2000 the autonomous underwater vehicle (AUV) Autosub was fitted with an in situ dissolved manganese analyzer and was used to study the spatial variability of this element together with oxygen, salinity, and temperature throughout the basin. Six along-loch transects were completed at either constant height above the seafloor or at constant depth below the surface. The ca. 4000 in situ 10-s-average dissolved Mn (Mnd) data points obtained provide a new quasi-synoptic and highly detailed view of the distribution of manganese in this fjordic environment not possible using conventional (water bottle) sampling. There is substantial variability in concentrations (600 nM) and distributions of Mnd. Surface waters are characteristically low in Mnd reflecting mixing of riverine and marine end-member waters, both of which are low in Mnd. The deeper waters are enriched in Mnd, and as the water column always contains some oxygen, this must reflect primarily benthic inputs of reduced dissolved Mn. However, this enrichment of Mnd is spatially very variable, presumably as a result of variability in release of Mn coupled with mixing of water in the loch and removal processes. This work demonstrates how AUVs coupled with chemical sensors can reveal substantial small-scale variability of distributions of chemical species in coastal environments that would not be resolved by conventional sampling approaches. Such information is essential if we are to improve our understanding of the nature and significance of the underlying processes leading to this variability.

Progressive Apraxia of Speech as a Sign of Motor Neuron Disease

Science.gov (United States)

Duffy, Joseph R.; Peach, Richard K.; Strand, Edythe A.

2007-01-01

Purpose: To document and describe in detail the occurrence of apraxia of speech (AOS) in a group of individuals with a diagnosis of motor neuron disease (MND). Method: Seven individuals with MND and AOS were identified from among 80 patients with a variety of neurodegenerative diseases and AOS (J. R. Duffy, 2006). The history, presenting…

NEUROBEHAVIORAL RELATIONSHIPS AND PUBERTY - ANOTHER TRANSFORMATION

NARCIS (Netherlands)

SOORANILUNSING, RJ

In a follow-up study of the Groningen Perinatal Project (GPP) on minor neurological dysfunction (MND) at 12 and 14 years the onset of puberty appeared to play a role. The children were selected on the presence (n = 185) and absence (n = 185) of MND at 9 years. Puberty was defined by the presence of

Selective impairment of verb processing associated with pathological changes in Brodmann areas 44 and 45 in the motor neurone disease-dementia-aphasia syndrome.

Science.gov (United States)

Bak, T H; O'Donovan, D G; Xuereb, J H; Boniface, S; Hodges, J R

2001-01-01

We report six patients with clinically diagnosed and electrophysiologically confirmed motor neurone disease (MND), in whom communication problems were an early and dominant feature. All patients developed a progressive non-fluent aphasia culminating in some cases in complete mutism. In five cases, formal testing revealed deficits in syntactic comprehension. Comprehension and production of verbs were consistently more affected those that of nouns and this effect remained stable upon subsequent testing, despite overall deterioration. The classical signs of MND, including wasting, fasciculations and severe bulbar symptoms, occurred over the following 6-12 months. The behavioural symptoms ranged from mild anosognosia to personality change implicating frontal-lobe dementia. In three cases, post-mortem examination has confirmed the clinical diagnosis of MND-dementia. In addition to the typical involvement of motor and premotor cortex, particularly pronounced pathological changes were observed in the Brodmann areas 44 (Broca's area) and 45. The finding of a selective impairment of verb/action processing in association with the dementia/aphasia syndrome of MND suggests that the neural substrate underlying verb representation is strongly connected to anterior cortical motor systems.

Maavalitsust ootavad muutused / Monika Puutsa

Index Scriptorium Estoniae

Puutsa, Monika

2004-01-01

Maavalitsuse haridus- ja kultuuriosakonna juhataja Raivo Peeters ei poolda haridus- ja teadusministeeriumi plaani võtta maavalitsustelt haridusjärelevalve funktsioon. Vajadus tõsta maavalitsuste haldussuutlikkust

Symptomatic treatments for amyotrophic lateral sclerosis/motor neuron disease.

Science.gov (United States)

Ng, Louisa; Khan, Fary; Young, Carolyn A; Galea, Mary

2017-01-10

Motor neuron disease (MND), which is also known as amyotrophic lateral sclerosis (ALS), causes a wide range of symptoms but the evidence base for the effectiveness of the symptomatic treatment therapies is limited. To summarise the evidence from Cochrane Systematic Reviews of all symptomatic treatments for MND. We searched the Cochrane Database of Systematic Reviews (CDSR) on 15 November 2016 for systematic reviews of symptomatic treatments for MND. We assessed the methodological quality of the included reviews using the Assessment of Multiple Systematic Reviews (AMSTAR) tool and the GRADE approach. We followed standard Cochrane study (review) selection and data extraction procedures. We reported findings narratively and in tables. We included nine Cochrane Systematic Reviews of interventions to treat symptoms in people with MND. Three were empty reviews with no included randomised controlled trials (RCTs); however, all three reported on non-RCT evidence and the remaining six included mostly one or two studies. We deemed all of the included reviews of high methodological quality. Drug therapy for painThere is no RCT evidence in a Cochrane Systematic Review exploring the efficacy of drug therapy for pain in MND. Treatment for crampsThere is evidence (13 RCTs, N = 4012) that for the treatment of cramps in MND, compared to placebo:- memantine and tetrahydrocannabinol (THC) are probably ineffective (moderate-quality evidence);- vitamin E may have little or no effect (low-quality evidence); and- the effects of L-threonine, gabapentin, xaliproden, riluzole, and baclofen are uncertain as the evidence is either very low quality or the trial specified the outcome but did not report numerical data.The review reported adverse effects of riluzole, but it is not clear whether other interventions had adverse effects. Treatment for spasticityIt is uncertain whether an endurance-based exercise programme improved spasticity or quality of life, measured at three months after the

Incidence of and risk factors for Motor Neurone Disease in UK women: a prospective study

Directory of Open Access Journals (Sweden)

Doyle Pat

2012-05-01

Full Text Available Abstract Background Motor neuron disease (MND is a severe neurodegenerative disease with largely unknown etiology. Most epidemiological studies are hampered by small sample sizes and/or the retrospective collection of information on behavioural and lifestyle factors. Methods 1.3 million women from the UK Million Women Study, aged 56 years on average at recruitment, were followed up for incident and/or fatal MND using NHS hospital admission and mortality data. Adjusted relative risks were calculated using Cox regression models. Findings During follow-up for an average of 9·2 years, 752 women had a new diagnosis of MND. Age-specific rates increased with age, from 1·9 (95% CI 1·3 – 2·7 to 12·5 (95% CI 10·2 – 15·3 per 100,000 women aged 50–54 to 70–74, respectively, giving a cumulative risk of diagnosis with the disease of 1·74 per 1000 women between the ages of 50 and 75 years. There was no significant variation in risk of MND with region of residence, socio-economic status, education, height, alcohol use, parity, use of oral contraceptives or hormone replacement therapy. Ever-smokers had about a 20% greater risk than never smokers (RR 1·19 95% CI 1·02 to 1·38, p = 0·03. There was a statistically significant reduction in risk of MND with increasing body mass index (pfor trend = 0·009: obese women (body mass index, 30 kg/m2 or more had a 20% lower risk than women of normal body mass index (20 to 2(RR 0·78 95% CI 0·65-0·94; p = 0·03. This effect persisted after exclusion of the first three years of follow-up. Interpretation MND incidence in UK women rises rapidly with age, and an estimated 1 in 575 women are likely to be affected between the ages of 50 and 75 years. Smoking slightly increases the risk of MND, and adiposity in middle age is associated with a lower risk of the disease.

Nostalgia Pühajärve kaldal / Paavo Kangur

Index Scriptorium Estoniae

Kangur, Paavo, 1966-

2006-01-01

Edgar Savisaare kunagise üleminekuvalitsuse ministrite kohtumisest Pühajärvel. Vt. samas: Eksriigiministri Raivo Vare toost; Eksmajandusministri Jaak Leimanni anekdoot naistest; Eksharidusminister Rein Loik arvab. Fotod

Poka ihh petuhh ne kljunet / Irina Kablukova

Index Scriptorium Estoniae

Kablukova, Irina

2008-01-01

Transiidiekspert Raivo Vare arvab, et valitsus peaks planeerima majanduse tulevikku ja kuulama ettevõtjaid. Riigikogu liige Taavi Veskimägi arvab, et majandusolukord paneb ministreid ettevõtjaid kuulama

25. XI esitleti Viviann Napi galeriis...

Index Scriptorium Estoniae

2004-01-01

Esitleti Berliinis elava kunstniku Ivar Kaasiku raamatut "Camera obscura, Ivar Kaasiku õlimaalid 2001-2004". Sissejuhatavad ja tõlgendavad tekstid on kirjutanud Harry Liivrand, Jaan Elken ja Raivo Kelomees

Maanoored peibutavad vanemaid internetti / Nils Niitra

Index Scriptorium Estoniae

Niitra, Nils, 1975-

2004-01-01

Internetifirma Kernel tegevjuhi Raivo Laatsi hinnangul soovivad internetiühendust eelkõige pere nooremad liikmed, Tartumaal kiiret sideteenust pakkuv ettevõte on kolme aastaga viinud selle mitmesaja maapereni

Transcriptome profiling of Lactococcus lactis subsp. cremoris CECT 8666 in response to agmatine

NARCIS (Netherlands)

Del Rio, Beatriz; Redruello, Begoña; Martin, M Cruz; Fernandez, Maria; de Jong, Anne; Kuipers, Oscar P; Ladero, Victor; Alvarez, Miguel A

2016-01-01

The dairy strain Lactococcus lactis subsp. cremoris CECT 8666 (formerly GE2-14) synthesizes the biogenic amine putrescine from agmatine via the agmatine deiminase (AGDI) pathway [1]. The AGDI cluster of L. lactis is composed by five genes aguR, aguB, aguD, aguA and aguC. The last four genes are

Estonia - üks tõeline eestimaine spaa / Dagmar Reinolt

Index Scriptorium Estoniae

Reinolt, Dagmar

2015-01-01

Heaoluspaa võtmes renoveeritud Estonia Spa Hotelsi ühest kompleksist. Rekonstrueerimisprojekti arhitektid: Raivo Kotov, Indrek Mikk. Rekonstrueerimisprojekti sisearhitektid: Raili Paling, Liis Lindvere, Kadri Kaldam, Kärt Loopalu. Valmimisaasta: 2015

Experiences and reflections of patients with motor neuron disease on breaking the news in a two-tiered appointment: a qualitative study.

Science.gov (United States)

Seeber, Antje A; Pols, A Jeannette; Hijdra, Albert; Grupstra, Hepke F; Willems, Dick L; de Visser, Marianne

2016-02-02

Breaking bad news should be fine-tuned to the individual patient, contain intelligible information, include emotional support and offer a tailor-made treatment plan. To achieve this goal in motor neuron disease (MND), neurologists of the amyotrophic lateral sclerosis (ALS) centre Amsterdam deliver the message on 2 separate visits within 14 days. To evaluate how patients with MND react to and view disclosure of the diagnosis, in this 2-tiered approach. Non-participating observations and in-depth interviews with patients were conducted in 1 tertiary ALS referral centre. Qualitative analysis consisted of inductive analysis of observation reports and verbatim typed out interviews. 10 2-tiered appointments were observed and 21 Dutch patients with MND interviewed. They experienced the straightforward message to be suffering from a fatal disease as devastating, yet unavoidable. The prospect of a short-term second appointment offered structure for the period immediately following the diagnosis. The time between appointments provided the opportunity for a first reorientation on their changed perspective on their life. The second appointment allowed for detailed discussions about various aspects of MND and a tailor-made treatment plan. The 2-tiered approach fits well with the way in which Dutch patients with MND process the disclosure of their diagnosis, gather information and handle the changed perspective on their life. It may serve as a model for other life-limiting diseases. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Frontotemporal lobar degeneration with ubiquitin pathology: an autopsy case presenting with semantic dementia and upper motor neuron signs with a clinical course of 19 years.

Science.gov (United States)

Yokota, Osamu; Tsuchiya, Kuniaki; Itoh, Yoshinori; Ishizu, Hideki; Akiyama, Haruhiko; Ikeda, Manabu; Kuzuhara, Shigeki; Otomo, Eiichi

2006-12-01

We report a case of a right-handed 74-year-old man who showed semantic dementia with a disease duration of 19 years. He initially presented with excessive use of pronouns and semantic paraphasia at the age of 55 years. Impairment of object recognition developed 5 years after the onset. Face recognition impairment and stereotypic behaviors developed 11 years after onset, and pyramidal signs 2 years before death. Pathological examination disclosed circumscribed severe atrophy in not only the bilateral temporal tips but also in the left precentral gyrus and pars opercularis in a motor speech field. Pyramidal tract involvement and loss of Betz cells were also evident. On the other hand, neurons in the anterior horns and hypoglossal nuclei were spared in number, although astrocytes were mildly proliferated. Ubiquitin-positive lesions were observed in the hippocampus, and frontal and temporal cortices. Neither Bunina bodies nor Pick bodies were present. These features clinically fit the international diagnostic criteria of semantic dementia and, histopathologically, frontotemporal lobar degeneration with motor neuron disease (FTLD-MND). This case suggests that (1) the distribution of cortical lesions associated with language disturbance is not uniform in FTLD-MND. It may be that only some cases of FTLD with ubiquitin pathology develop semantic dementia despite the high incidence of language disturbance, and (2) the precentral gyrus can be severely affected in FTLD-MND. After reviewing previous cases of FTLD-MND with a clinical course of more than 10 years, we also noticed that (3) FTLD-MND cases with a long disease duration often show upper motor neuron-predominant involvement.

Determinants of accepting non-invasive ventilation treatment in motor neurone disease: a quantitative analysis at point of need.

Science.gov (United States)

Cousins, Rosanna; Ando, Hikari; Thornton, Everard; Chakrabarti, Biswajit; Angus, Robert; Young, Carolyn

2013-01-01

Objectives : Motor neurone disease (MND) progressively damages the nervous system causing wasting to muscles, including those used for breathing. There is robust evidence that non-invasive ventilation (NIV) relieves respiratory symptoms and improves quality of life in MND. Nevertheless, about a third of those who would benefit from NIV decline the treatment. The purpose of the study was to understand this phenomenon. Design : A cross-sectional quantitative analysis. Methods : Data including age, sex, MND symptomatology, general physical and mental health and psychological measures were collected from 27 patients and their family caregivers at the point of being offered ventilatory support based on physiological markers. Results : Quantitative analyses indicated no difference in patient characteristics or symptomatology between those who tolerated ( n  = 17) and those who declined ( n  = 10) NIV treatment. A comparison of family caregivers found no differences in physical or mental health or in caregiving distress, emphasising that this was high in both groups; however, family caregivers supporting NIV treatment were significantly more resilient, less neurotic and less anxious than family caregivers who did not. Regression analyses, forcing MND symptoms to enter the equation first, found caregiver resilience:commitment the strongest predictor of uptake of NIV treatment adding 22% to the 56% explained variance. Conclusion : Patients who tolerated NIV treatment had family caregivers who cope through finding meaning and purpose in their situation. Psychological support and proactive involvement for family caregivers in the management of the illness situation is indicated if acceptance of NIV treatment is to be maximised in MND.

Oodatakse Autolivi ülevõtmispakkumist / Annika Matson, Sirje Niitra

Index Scriptorium Estoniae

Matson, Annika, 1976-

2005-01-01

Norma omaniku Autolivi osatähtsuse suurenemine viitab, et rootslased teevad varsti Norma kaasaktsionäridele ülevõtmispakkumise. Diagramm: Norma müügis domineerib Autoliv. Kommenteerib Raivo Sormunen

Perspectives on the emblems of the nation in contemporary Estonian and Anglo-Welsh poetry / Ene-Reet Soovik

Index Scriptorium Estoniae

Soovik, Ene-Reet, 1968-

2000-01-01

Kaasaegse eesti luule ja Walesi ingliskeelse luule võrdlemiseks on kasutatud uusi antoloogiaid: Eesti luule antoloogia II (koost. Raivo Kuusk, 1998), Twentieth-century anglo-welsh poetry (ed. Dannie Abse, 1997)

Tallinna Teletorn = Tallinn's Television Tower / Andrus Kõresaar

Index Scriptorium Estoniae

Kõresaar, Andrus, 1975-

2013-01-01

Renoveeritud Teletornist. Ekspositsiooni autorid: Andrus Kõresaar, Liis Lindvere, Raili Paling, sisearhitektid: Liis Lindvere, Raili Paling, Margit Argus (KOKO Arhitektid). Arhitekti ja ESLi aastapreemiate žürii liikme Raivo Puusepa arvamus

Kahest nüüdismuusika neljapäevast : Anti Marguste, võeti tunnike tähelepanu / Igor Garšnek

Index Scriptorium Estoniae

Garšnek, Igor, 1958-

2011-01-01

15. septembril Estonia kontserdisaalis sarjas "Lõunamuusika" toimunud kontserdist "Antimees, Anti Marguste 80", kus esinesid Pärnu Linnaorkester, RAM, Piret Aidulo (orel), Raivo Tafenau (saksofon), Jüri Alperteni ja Ants Sootsi dirigeerimisel

Kunstfotograafid tõid pildid Valka / Marje Laugen

Index Scriptorium Estoniae

Laugen, Marje

2004-01-01

Valga kultuurikeskuses avati Ungari Vabariigi Smogy maakonna algatatud rahvusvahelise kunstiprojekti Changing World Images raames fotonäitus "Teatriprintsiip eesti fotos". Näituse organisaator Raivo Behrsin, kuraator Peeter Linnap. Vallo Kalamehe kommentaar

Inimesed ja mesilased / Rein Tootmaa

Index Scriptorium Estoniae

Tootmaa, Rein

2005-01-01

Nukufilm "Gene+ratio" : stsenarist, kunstnik ja režissöör Mait Laas : konsultant Paavo Matsin : operaatorid Ragnar Neljandi, Raivo Möllits : helilooja Tiit Kikas : Nukufilm OÜ - Icon Film (Saksamaa) 2005

Kelomehele preemia Baseli festivalil

Index Scriptorium Estoniae

2000-01-01

Baselis festivalil "VIPER - International Festival for Film Video and New Media" tunnistati parimaks CD-ROMiks Gustav Deutschi/Anna Schimeki "Odysee today", netiprojektiks itaallaste "01.ORG", äramärkimispreemia - Raivo Kelomehe "Videoweaver"

Nõukogude aeg naaseb piimapakis / Askur Alas

Index Scriptorium Estoniae

Alas, Askur, 1973-

2004-01-01

Tallinna Piimatööstuse kaubamärgi Turbo-lehm kolmnurkse kartongpakendi kujunduse tegi reklaamifirma DDB Eesti AS, kellega koos valmis ka Turbo-lehma tegelaskuju. Lehma joonistas kunstnik Raivo Tihhonov. Reklaamifirmade kommentaarid

Kurdi illegaal üritas pagasiruumis pageda / Rasmus Kagge

Index Scriptorium Estoniae

Kagge, Rasmus, 1977-

2004-01-01

Ilmunud ka: Infopress, 28. mai, nr. 22, 2004, lk. 32. Kurdi illegaal Karwan Jamal Ibrahim tabati kiirlaeva Autoexpress autotekilt Mercedese pagasiruumist. Vt. samas intervjuud Tallinna reisisadama piiripunkti ülema Raivo Männikuga

Üliohtliku laadungiga rongid plaanitakse Tallinnast välja saata / Signe Kalberg

Index Scriptorium Estoniae

Kalberg, Signe, 1959-

2006-01-01

Valitsusele esitatakse kolm Tallinna raudteeümbersõidu varianti, analüüsi koostamisse kaasati AS Deloitte&Touche Eesti. Kaart: Tallinna raudteeümbersõit. Kommenteerivad: Raivo Uukkivi, Ain Kaljurand, Toomas Vitsut

Anneli Remme soovitab : Kammerdžässi kava "Jõulud mõisas" / Siim Nestor

Index Scriptorium Estoniae

Nestor, Siim, 1974-

2006-01-01

Eesti-Tšiili trio Raivo Tafenau - Meelis Vind - Ricardo Padilla kontsertidest sarja "Mõisaromantika" raames 25. nov. Taagepera lossis Valgamaal, 26. nov. Tõstamaa mõisas Pärnumaal ja 16. dets. Vihterpalu mõisas Harjumaal

Viljandi mõisa aida kohandamine Eesti Pärimusmuusika Keskuseks = Renovation of the Viljandi manor's storehouse into the Estonian Traditional Music Centre / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2009-01-01

Hoone arhitektuuriajaloolised eritingimused koostas Anne Lass, arhitekt on Raivo Mämdmaa, sisearhitekt Kersti Leinbock, konstruktor Hans Priks, sepiste autor Heigo Jelle. Hoonel on klaasist juurdeehitis. Žürii hinnang kultuurkapitali aastapreemiale esitatud sisekujundusele

ETV uus seriaal "Vistrik" kavatseb nime muuta / Anne Vetik

Index Scriptorium Estoniae

Vetik, Anne

2006-01-01

Toimuvad ETV uue krimisarja "Vistrik" võtted, stsenarist Mihkel Ulman, režissöör Ain Prosa, produtsent Raivo Suviste, kesksetes rollides Marko Matvere, Jaan Rekkor, Elisabet Tamm, tootjaks OÜ Balti Video

Ohtlikud lennud / Simo Meinert

Index Scriptorium Estoniae

Meinert, Simo

2006-01-01

ETV uus algupärane krimisari "Ohtlik lend" : stsenarist Mihkel Ulman : lavastaja Ain Prosa : produtsent Raivo Suviste : peaosades Elisabet Tamm, Marko Matvere : Balti Video. Sama ka : Teleleht nr. 38, lk. 6-7 : ill

Valga linnal valmis lõpuks oma logo / Liina Ulm

Index Scriptorium Estoniae

Ulm, Liina

2004-01-01

Valga linna logo leidmiseks korraldatud konkursid ebaõnnestusid. Linnavalitsuse töörühma ideede põhjal kujundas linnale logo Raivo Behrsin. Linna tunnuslause '1 linn, 2 riiki' autoriks on Andres Norak

Lugupeetud kunstnikud, arhitektid ja sõbrad!

Index Scriptorium Estoniae

2001-01-01

Eesti Kunstnike Liidu ja Eesti Arhitektide Liidu aastavahetuspeo kava 28. XII. Esinevad Raivo Kelomees (EKA ja Tartu Kõrgema Kunstikooli videoprojektid), EKA moeosakond. Nova Moda esitleb: Ruta Depp, Ketlin Bachman, Riina Põldroos, Kati Simpson

Nutritional advice and treatment by dietitians to patients with amyotrophic lateral sclerosis/motor neurone disease: a survey of current practice in England, Wales, Northern Ireland and Canada.

Science.gov (United States)

Rio, A; Cawadias, E

2007-02-01

The management of amyotrophic lateral sclerosis/motor neurone disease (ALS/MND) has shifted from an attitude of nihilism to treatments that prolong survival and offer hope. Nutrition is an integral component of ALS/MND care requiring coordination among acute and community multi-disciplinary teams (MDT). Evidence-based nutrition guidelines exist for this patient group but their use among dietitians is unknown. The aim of this study was to survey the knowledge, practice and guideline use of dietitians working in ALS/MND centres/clinics across England, Wales, Northern Ireland (EWNI) and Canada. Dietetic contact details were obtained from the Motor Neurone Disease Association (MNDA) and the ALS Society of Canada (ALSSC) websites. Telephone interviews were conducted with 23 dietitians using a standardized questionnaire. Multi-disciplinary team membership was high (78%). Only 22% dietitians had >4-years experience in ALS/MND care. Dietitians reported using body weight, percentage weight loss (PWL) and body mass index (BMI) to assess nutritional status. Equations used to estimate energy and protein requirements differed. Most frequent dietary advice was high calorie, texture modification and prescription nutritional supplements. Artificial nutrition and hydration (ANH) was discussed when patients developed dysphagia, energy intake was inadequate, weight loss of 10% or forced vital capacity (FVC) was reduced. A percutaneous endoscopic gastrostomy (PEG) service was available at all clinics/centres. Nutritional assessment techniques and dietary advice should be standardized. Dietetic collaboration at national and international level is recommended to reduce professional isolation. Training and support in ALS/MND nutrition should be made available as part of post-dietetic registration. Further dietetic research is required to stimulate nutritional care.

Analysis on energy consumption of drying process for dried Chinese noodles

International Nuclear Information System (INIS)

Wang, Zhenhua; Zhang, Yingquan; Zhang, Bo; Yang, Fuguang; Yu, Xiaolei; Zhao, Bo; Wei, Yimin

2017-01-01

Highlights: • Energy analysis of a tunnel dryer for dried Chinese noodles is completed. • Energy saving performance of dryers with different inlet air was compared. • MND was developed and evaluated, and the efficiency and throughput was improved. - Abstract: Drying is an important operation during the production of dried Chinese noodles, and the energy consumption from drying accounts for approximately 60% of the total energy consumption during the manufacturing process. To investigate the energy consumption and throughput of dryers for dried Chinese noodles, experiments were conducted using a new 130-m long tunnel dryer with two lines of noodles (ND) and an old 60-m long tunnel dryer with five lines of noodles (OD). The energy saving effects of a modified new 130-m long tunnel dryer (MND), which was only modified through the inclusion of automatic control for temperature and humidity without any modifications to the oil heater or ND dryer structure, were also compared. The energy saving effect was determined from the enthalpy difference between the inlet and outlet humid air of the ND and MND. Finally, the MND was found to be better than ND in terms of energy efficiency and throughput, and trends for the future of noodle drying were discussed.

Electrospinning of Nanodiamond-Modified Polysaccharide Nanofibers with Physico-Mechanical Properties Close to Natural Skins

Directory of Open Access Journals (Sweden)

Mina Mahdavi

2016-07-01

Full Text Available Electrospinning of biopolymers has gained significant interest for the fabrication of fibrous mats for potential applications in tissue engineering, particularly for wound dressing and skin regeneration. In this study, for the first time, we report successful electrospinning of chitosan-based biopolymers containing bacterial cellulous (33 wt % and medical grade nanodiamonds (MND (3 nm; up to 3 wt %. Morphological studies by scanning electron microscopy showed that long and uniform fibers with controllable diameters from 80 to 170 nm were prepared. Introducing diamond nanoparticles facilitated the electrospinning process with a decrease in the size of fibers. Fourier transform infrared spectroscopy determined hydrogen bonding between the polymeric matrix and functional groups of MND. It was also found that beyond 1 wt % MND, percolation networks of nanoparticles were formed which affected the properties of the nanofibrous mats. Uniaxial tensile testing of the woven mats determined significant enhancement of the strength (from 13 MPa to 25 MP by dispersion of 1 wt % MND. The hydrophilicity of the mats was also remarkably improved, which was favorable for cell attachment. The water vapor permeability was tailorable in the range of 342 to 423 µg·Pa−1·s−1·m−1. The nanodiamond-modified mats are potentially suitable for wound healing applications.

Electrospinning of Nanodiamond-Modified Polysaccharide Nanofibers with Physico-Mechanical Properties Close to Natural Skins

Science.gov (United States)

Mahdavi, Mina; Mahmoudi, Nafiseh; Rezaie Anaran, Farzad; Simchi, Abdolreza

2016-01-01

Electrospinning of biopolymers has gained significant interest for the fabrication of fibrous mats for potential applications in tissue engineering, particularly for wound dressing and skin regeneration. In this study, for the first time, we report successful electrospinning of chitosan-based biopolymers containing bacterial cellulous (33 wt %) and medical grade nanodiamonds (MND) (3 nm; up to 3 wt %). Morphological studies by scanning electron microscopy showed that long and uniform fibers with controllable diameters from 80 to 170 nm were prepared. Introducing diamond nanoparticles facilitated the electrospinning process with a decrease in the size of fibers. Fourier transform infrared spectroscopy determined hydrogen bonding between the polymeric matrix and functional groups of MND. It was also found that beyond 1 wt % MND, percolation networks of nanoparticles were formed which affected the properties of the nanofibrous mats. Uniaxial tensile testing of the woven mats determined significant enhancement of the strength (from 13 MPa to 25 MP) by dispersion of 1 wt % MND. The hydrophilicity of the mats was also remarkably improved, which was favorable for cell attachment. The water vapor permeability was tailorable in the range of 342 to 423 µg·Pa−1·s−1·m−1. The nanodiamond-modified mats are potentially suitable for wound healing applications. PMID:27399726

Electrospinning of Nanodiamond-Modified Polysaccharide Nanofibers with Physico-Mechanical Properties Close to Natural Skins.

Science.gov (United States)

Mahdavi, Mina; Mahmoudi, Nafiseh; Rezaie Anaran, Farzad; Simchi, Abdolreza

2016-07-07

Electrospinning of biopolymers has gained significant interest for the fabrication of fibrous mats for potential applications in tissue engineering, particularly for wound dressing and skin regeneration. In this study, for the first time, we report successful electrospinning of chitosan-based biopolymers containing bacterial cellulous (33 wt %) and medical grade nanodiamonds (MND) (3 nm; up to 3 wt %). Morphological studies by scanning electron microscopy showed that long and uniform fibers with controllable diameters from 80 to 170 nm were prepared. Introducing diamond nanoparticles facilitated the electrospinning process with a decrease in the size of fibers. Fourier transform infrared spectroscopy determined hydrogen bonding between the polymeric matrix and functional groups of MND. It was also found that beyond 1 wt % MND, percolation networks of nanoparticles were formed which affected the properties of the nanofibrous mats. Uniaxial tensile testing of the woven mats determined significant enhancement of the strength (from 13 MPa to 25 MP) by dispersion of 1 wt % MND. The hydrophilicity of the mats was also remarkably improved, which was favorable for cell attachment. The water vapor permeability was tailorable in the range of 342 to 423 µg·Pa(-1)·s(-1)·m(-1). The nanodiamond-modified mats are potentially suitable for wound healing applications.

14. VII avati Rael Arteli galerii fotoruumis...

Index Scriptorium Estoniae

2004-01-01

Anu Allase kureeritud näitus "Juhitud reisid/Guided Tours". Näitusel osalevad Liisi Peets, Katrin Tees, Piret Räni, Anu Vahtra, Daisy Lappard, Tiit Sokk (Ulvi Tiit & Marili Sokk), Raivo Hool ja Rataplan

Lehekähmlus Rae vallas / Gert D. Hankewitz

Index Scriptorium Estoniae

Hankewitz, Gert D.

2008-01-01

Rae vallavanem Raivo Uukkivi peab valla ametliku lehe kaudu võitlust vallavõimu kritiseeriva kohaliku ajalehega Rae Valla Leht, mille asutas valla endine pressiesindaja. Vt. samas: Kriitilise vallalehe elu pole lihtne. Kommenteerib Maret Arge

Hunnitud hütid / Karin Paulus

Index Scriptorium Estoniae

Paulus, Karin, 1975-

2016-01-01

Arhitektuuribüroos KOKO Arhitektid (Raivo Kotov, Andrus Kõresaar, Sten-Mark Mändmaa, Indrek Mikk, Martin Tago, Liis Uustal, Maia Grimitliht, Raili Paling, Kadri Kaldam) kavandatud puidust matkahütid Norras Skåpetis

Tallinn-Väike rongijaama ehitati tark näidiskorter / Toivo Tänavsuu

Index Scriptorium Estoniae

Tänavsuu, Toivo

2007-01-01

Kinnisvaraarendaja Landscape Invest rajatud näidiskorterist Tark Kodu. Idee autoriks on Märt Mathisen. Küsimustele vastab Raivo Raestik firmast Yoga Intelligence, kus töötati välja korteri tehnoloogiline lahendus

Mintuleasa tänavas : lugu K.-st ehk kohtade kehastumisest ja kultuurilisest kapitalist / Indrek Peil

Index Scriptorium Estoniae

Peil, Indrek, 1973-

2005-01-01

Kehastunud ruumilistest suhetest linnas, vanade tööstushoonete taaskasutamisest, Tallinna tselluloosivabrikust, kultuurivabrikust, Raivo Kotovi ja Andrus Kõresaare Tallinna tselluloosivabriku otsa projekteeritavast pealeehitusest (elu- ja ärihoone Fahle Maja, KOKO Arhitektuuristuudio, 2004-2005) jm.

International conference "Cultural Plurality in Estonia : Policies and Solutions"

Index Scriptorium Estoniae

2000-01-01

Ettekandjad: Katrin Saks, Mall Hellam, Mati Luik, Kirsti Häkkinen, Vello Pettai, Ivi Proos, Katri Raik, NiinaOrhimenko, Ib Ostergaard Rasmussen, Urve Läänemets, Jüri Valge, Aleksander Dusman, Raivo Juurak, Rein Ruutsoo

Minister proposes re-introducing ETV commercials / Kairi Kurm

Index Scriptorium Estoniae

Kurm, Kairi

2005-01-01

Kultuuriminister Raivo Palmaru tegi ettepaneku hakata ETV-s taas reklaami näitama, millest saadud tuludega suurendada telekanali eelarvet. Kanal 2 ja TV3 juhtide arvates mõjutaks see meediaturu stabiilsust ning oleks ebaaus konkurents

Veider nelik jätkab!

Index Scriptorium Estoniae

2008-01-01

Arvutiga animeeritud USA koguperefilmist "Madagaskar 2" (lavastanud Tim McGrath ja Eric Darnell, eesti keeles loevad teksti Karol Kuntsel, Andero Ermel, Evelin Pang, Argo Aadli, Mait Malmsten, Raivo E. Tamm, Andrus Vaarik, Anne Reemann jt)

Vabaõhulavastuse "Jõujaam" proovid käivad täie hooga / Jan Rahman

Index Scriptorium Estoniae

Rahman, Jan, 1975-

2007-01-01

Leevaku hüdroelektrijaama juures etendub jaanipäeva paiku Jan Rahmani kirjutatud näitemäng "Jõujaam", lavastaja Raivo Adlas. Mängib Räpina näitemänguseltskond. Näitekirjanik tutvustab lavastust

Investors ponder private bridge for Narva-Ivangorod / Gary Peach, Joel Alas

Index Scriptorium Estoniae

Peach, Gary

2007-01-01

Tiit Vähi ja Andrei Katkovi lubadusest ehitada Narva jõele uus sild, kuna valitsused silla ehitamises niipea kokkuleppele ei jõua. Tiit Vähi, Edgar Savisaare, Raivo Vare ja Igor Gräzini arvamused

USA armee uus digitaalmustriline välivorm / Liisa Mäemets

Index Scriptorium Estoniae

Mäemets, Liisa

2005-01-01

Ameeriklaste uue mustriga sõdurite universaalsest välivormist, mis võimaldab sulanduda metsa-, kõrbe- kui ka linnakeskkonda. Kommenteerib kaitseväe peastaabi logistikaosakonna ülem Raivo Tamm. Art. on koost. internetiallikate põhjal

Poliitikud või eksperdid ? / Aarne Ruben

Index Scriptorium Estoniae

Ruben, Aarne, 1971-

2009-01-01

ETV saates "Foorum" esinesid 21. jaanuaril Indrek Neivelt, Erik Terk, Ivar Raig ja Raivo Vare, kes avaldasid arvamust, et valitsuses oleks vaja rohkem majandusharidusega inimesi. Autori arvates on erialast kõrgharidust vaja kõikjal riigiametites

Data Redistribution through MY NASA DATA: Striving to bring authentic NASA data into education

Science.gov (United States)

Lewis, P. M.; Oostra, D.; Oots, P.; Chambers, L. H.; Moore, S.; Crecelius, S.; Taylor, J.

2012-12-01

The Mentoring and inquirY using NASA Data on Atmospheric and Earth science for Teachers and Amateurs (MY NASA DATA or MND) project was launched in 2004 to bring authentic data into K-12 education. The MND website features a Live Access Server (LAS), an open source tool which allows users to customize data sets to suit their individual needs, choosing from among 200 global Level 3 data sets. Approximately 120 lesson plans that utilize the available parameters are offered to help teachers and students get started with data exploration. Grade appropriate data documentation is also provided (with continual efforts to improve it to better meet the needs of this target audience). Through inquiry and lesson utilization, educators have several connection points to the data. As classrooms shift to problem-based and inquiry learning, the need for a data visualizer/server increases. Through numerous and growing connections to NASA satellite missions, and with access to data as a built-in feature, MND effectively fills this niche to provide a first level of data re-use that is friendly to the K-12 community. Offering a wide variety of data sets allows MND to support many science topics within the K-12 curriculum while extending the use of scientific data from NASA Earth science satellites. Lessons, created by educators across the country, allow MND to connect with the classroom teacher and to meet their data needs. As technology continues to evolve, a second level of data re-use becomes both interesting and possible. Thus, the MND team is now exploring new web and mobile platforms that can be built and distributed on an accelerated time cycle to keep up with information technology developments. With implementation of these new platforms come challenges in promoting new items to the education community, the public, and other potential users. Included in the list of challenges are: ever-evolving technology, prediction of the market, web/mobile platforms, and time-to-market for

Interjer ofisa otrazhajet litso firmõ / Nelli Pello

Index Scriptorium Estoniae

Pello, Nelli

2008-01-01

Tallinnas Veerenni tänaval asuva MTV Eesti muusikakanali kontori kujundusest. Kujundasid Liina Vaino ja Raivo Raidvee. Tallinnas Kalamajas asuva disainibüroo Velvet tööruumide kujundusest. Kujundas Taavi Aunre. Kommenteerib sisearhitekt Kristiina Voolaid

Pärnu täna : Seegi maja kaks aukirja / Tõnu Kann

Index Scriptorium Estoniae

Kann, Tõnu, 1957-

2001-01-01

Pärnus Hospidali 1 asuva muinsuskaitsealuse Seegi maja ajaloost ja restaureerimisest tehnik-arhitekti Leevi Soku kontseptsiooni järgi. Maja omanik Raivo Tõnismaa ja sisekujunduse teinud Omar Volmer said tehtud töö eest muinsuskaitse aukirjad

Kinnisvara kokkuostja pakub hinna 24 tunniga / Anne Oja

Index Scriptorium Estoniae

Oja, Anne, 1970-

2008-01-01

Ilmunud ka: Delovõje Vedomosti 11. juuni lk. 8. Endise Eri Kinnisvara maakleri Aivar Soola ja Raivo Juhansoni firma alustab kinnisvara kokkuostu kiirmüügi korras, lubades kuni 85-protsendilise turuhinnaga ostupakkumist 24 tunni jooksul

Mõõduks vaataja naer / Tarmo Teder

Index Scriptorium Estoniae

Teder, Tarmo, 1958-

2002-01-01

Kolm esimest osa ETV poliitilise pila nukushõust "Pehmed ja karvased" : stsenaristid Toomas Kall ja Andrus Kivirähk : idee autor, režissöör ja kunstnik Hardi Volmer : produtsent, idee autor Raivo Suviste

Karvased ja sulelised / Tambet Kaugema

Index Scriptorium Estoniae

Kaugema, Tambet

2002-01-01

Kaks esimest osa ETV poliitilise pila nukushõust "Pehmed ja karvased" : stsenaristid Toomas Kall ja Andrus Kivirähk : idee autor, režissöör ja kunstnik Hardi Volmer : produtsent, idee autor Raivo Suviste

Yoga OÜ - kas suur mull või paljulubav väikefirma? / Raigo Neudorf

Index Scriptorium Estoniae

Neudorf, Raigo

2008-01-01

Iseõppiva intelligentse hoonesüsteemi arendamise ja väljatöötamisega tegeleva firma Yoga OÜ arengut ja kavatsusi maailmaturul tutvustavad ettevõtjad Priit Vimberg ja Raivo Raestik. Vt. samas: Investorite otsinguil; Revolutsiooniline toode

Energiasõltumatuse ohtlik fantaasia / A. F. Alhajji, Gavin Longmuir ; tõlk. Marek Laane

Index Scriptorium Estoniae

Alhajji, A. F.

2007-01-01

Autorid leiavad, et maailmas üha häälekamalt kõlav soov taotleda energiasõltumatust on absurdne, sest selle poole püüdlevate maade energeetiline julgeolek tegelikult väheneb. Kommenteerib energeetikaekspert Raivo Vare

Relationships between myonuclear domain size and fibre properties in the muscles of Thoroughbred horses.

Science.gov (United States)

Kawai, M; Kuwano, A; Hiraga, A; Miyata, H

2010-11-01

The myonuclear domain (MND) is the region of cytoplasm governed by a single myonucleus. Myonuclear domain size is an important factor for muscle fibre plasticity because each myonucleus has limitations in the capacity of protein synthesis. Previous studies have demonstrated that differences in MND size exist in different fibre types in several species, including horses. To understand the basic mechanism of muscle plasticity, the relationships between MND size, muscle fibre type population and metabolic properties of skeletal muscles throughout the whole body in Thoroughbred horses were examined. Post mortem samples were taken from 20 muscles in 3 Thoroughbred horses aged 3-5 years of age. Fibre type population was determined on serial cross sections of each muscle sample, stained for monoclonal antibodies to each myosin heavy chain isoform. Oxidative (succinic dehydrogenase; SDH) and glycolytic (phosphofructokinase; PFK) enzyme activities were determined spectrophotometrically in each muscle sample. Furthermore, 30 single fibres were isolated from each muscle under stereomicroscopy and then fibre volume and myonuclear number for a given length analysed under confocal microscopy. The MND size of each single fibre was measured after normalisation of sarcomere length to 2.8 µm by staining with membrane-specific dye. Immunohistochemical staining indicated that soleus, vastus lateralis and gluteus medius muscles had the highest percentage of type I, IIa and IIx muscle fibre, respectively. Biochemical analysis indicated highest activities of SDH and PFK in diaphragm and longissimus lumborum muscles, respectively. MNDs were largest in the splenius muscle and smallest in the soleus and masseter muscles. Myonuclear domain size is significantly related to type I muscle fibre population, but not to SDH activities of the muscles. The MND size of muscle fibre depends on fibre type population rather than mitochondrial enzyme activities. © 2010 EVJ Ltd.

Kiigutab kuuski ja porgandeid / Marko Mägi

Index Scriptorium Estoniae

Mägi, Marko

2000-01-01

Andrus Kõressaare ja Raivo Kotovi EXPO 2000 Eesti paviljoni projektist. R. Kotovist, tema tulevikuplaanidest, saavutustest enne EXPO-konkursi võitu (väljapanek näitusel 'Biotoopia',1998. a. ühistöö Marko Laimrega 'Egoistically Correct').

Eesti Energia esindused = Eesti Energia branches / Andres Labi, Janno Roos

Index Scriptorium Estoniae

Labi, Andres, 1977-

2013-01-01

Eesti Energia klienditeeninduse kontorite sisekujundusest. Autorid: Janno Roos, Andres Labi ja Liisa Põime (Ruumilabor). Visuaalne identiteet: Tank.Teenuste disain: Urmas Pastarus. ESLi aastapreemiate žürii esimehe Kaido Kivi ning žürii liikme Raivo Puusepa arvamused

Alexela välisomanik plaanib lisaraha kaasamist. Eesti on suure raha jaoks ebahuvitav / Hannes Sarv

Index Scriptorium Estoniae

Sarv, Hannes

2011-01-01

Alexela Logisticsi omanikeringi kuuluv Puma Energy plaanib minna börsile. Puma Energy äripartneri Heiti Hääle sõnul Puma oma tegevust Eestis laiendama ei tõtta, sest siin pole kuhugi investeerida. Raivo Vare kommentaare

Peer ja Protassov tuuleveskite vastu / Jaanus Kulli

Index Scriptorium Estoniae

Kulli, Jaanus, 1955-

1999-01-01

H. Ibseni "Peer Gynt" "Endlas", lavastaja A.-E. Kerge, peaosas Raivo Trass,.esietendus 10. okt. 1998. L. Tolstoi "Elav laip" "Ugalas", lavastaja K. Komissarov, peaosas Andres Lepik, esietendus 26. sept. 1998. Kokkuvõte inglise keeles lk. 94

Filmi- ja videofestival kolis Port Arturisse / Silja Joon

Index Scriptorium Estoniae

Joon, Silja, 1966-

2009-01-01

Pärnu filmi- ja videofestival 2009 Port Artur 2 kaubanduskeskuses. Näeb videoinstallatsioonide kava ja noorteprogrammi. Korraldab Non Grata. Videoprogrammi koostab Al Paldrok, virtuaalmeedia osa Raivo Kelomees, filmiprogrammi Andres Maimik ja installatsioonide erikava Taje Tross. Festivali kava

Vzgljad s obeihh storon ekrana : obrushivshiisja most / Boris Tuch

Index Scriptorium Estoniae

Тух, Борис, 1946-

2007-01-01

Vene telekanali Pervõi Kanal Tallinn-Moskva telesillana vormistatud poliitiline väitlussaade "Otsustage ise" 18. jaanuaril, kus Eesti poolt esindasid Riigikogu liige Raivo Järvi ja Eesti saadik Moskvas Marina Kaljurand, Moskvat teiste seas ka Nikita Mihhalkov

Eesti paviljon Hannoveri maailmanäitusel EXPO 2000 = Estonian Pavilion at Hannover World Exposition EXPO 2000 / Andrus Kõresaar

Index Scriptorium Estoniae

Kõresaar, Andrus

2000-01-01

Eesti paviljoni arhitektuurist. Autorid Andrus Kõresaar, Raivo Kotov. Sisekujundajad A. Kõresaar, R. Kotov, Tiit Tael, Hannes Praks. Konstruktsioonid: Neoprojekt. Saksamaa-poolne kontaktarhitektuuribüroo: KSP Engel & Zimmermann. 15 ill.: korruste plaanid, lõiked, välis- ja sisevaated

Pühapäev kunsti ja muusikaga / Mari Hiiemäe

Index Scriptorium Estoniae

Hiiemäe, Mari

2008-01-01

Jazzkaare 20. aprillil korraldatavast kunsti ja muusika pühapäevast Niguliste muuseumis (esineb East-West Quartet), Tallinna Kunstihoones (Estonian Guitar Octet), Rotermanni soolalaos (Raivo Tafenau ja Meelis Vindi duo) ja Kumu auditooriumis (laulja Kelli Uustani plaadiesitlus)

Keskerakonna nõrk PR-käik / Aivar Hundimägi

Index Scriptorium Estoniae

Hundimägi, Aivar, 1975-

2008-01-01

Seoses keskerakondlastest ettevõtjate Richard Siku ja Heldur Undi sattumisega bordelliskandaali on Keskerakonna aukohtu esimees Ain Seppik pöördunud järelpärimisega politseiameti peadirektori Raivo Aegi ja riigi peaprokuröri Norman Aasa poole

Jõekääru Jazz täitis eesmärgi nii korraldajate, esinejate kui publiku poolelt / Allan Liik, Hedvig Hanson, Andre Maaker, Ain Agan...[jt.] ; foto ja küsitl. Kaire Tensuda

Index Scriptorium Estoniae

2007-01-01

Jõekääru Jazz'ile järgneval nädalal tõi ürituse peakorraldaja Allan Liik toimetusse seal esinenud muusikud. Vestlusringis olid: Allan Liik, Hedvig Hanson, Andre Maaker, Ain Agan, Raivo Tafenau ja Sergio Bastos

Meie staarid raadioteatris

Index Scriptorium Estoniae

2005-01-01

Raivo Küti raadioetenduses "Papa" teeb oma esimese kuuldemängu rolli Ülle Lichtfeldt. August Gailiti novelli "Seeba kuninganna" järgi loodavas kuuldemängus "Toomas Nipernaadi talv" saab kuulda peaosas Üllar Saaremäed

Mis on siis see Solaris? / Ike Volkov

Index Scriptorium Estoniae

Volkov, Ike, 1951-

2009-01-01

Tallinna kesklinnas avatud meelelahutus- ja elustiilikeskusest Solaris. Arhitekt Raivo Puusepp. Lühidalt 2004. a. toimunud keskuse avalikust arhitektuurikonkursist, mille võitis Arhitektuuriagentuur. Uue Sakala keskuse (Solarise) eskiisprojekti läbivaatamistest ja aruteludest linnaplaneerimise ametis, arvamustest ja tehtud ettepanekutest

A metabolomic comparison of mouse models of the Neuronal Ceroid Lipofuscinoses

Energy Technology Data Exchange (ETDEWEB)

Salek, Reza M.; Pears, Michael R. [University of Cambridge, Department of Biochemistry and Cambridge Systems Biology Centre (United Kingdom); Cooper, Jonathan D. [King' s College London, Pediatric Storage Disorders Laboratory, Department of Neuroscience, Institute of Psychiatry (United Kingdom); Mitchison, Hannah M. [Royal Free and University College Medical School, Department of Paediatrics and Child Health (United Kingdom); Pearce, David A. [Sanford School of Medicine of the University of South Dakota, Department of Pediatrics (United States); Mortishire-Smith, Russell J. [Johnson and Johnson PR and D (Belgium); Griffin, Julian L., E-mail: jlg40@mole.bio.cam.ac.uk [University of Cambridge, Department of Biochemistry and the Cambridge Systems Biology Centre (United Kingdom)

2011-04-15

The Neuronal Ceroid Lipofuscinoses (NCL) are a group of fatal inherited neurodegenerative diseases in humans distinguished by a common clinical pathology, characterized by the accumulation of storage body material in cells and gross brain atrophy. In this study, metabolic changes in three NCL mouse models were examined looking for pathways correlated with neurodegeneration. Two mouse models; motor neuron degeneration (mnd) mouse and a variant model of late infantile NCL, termed the neuronal ceroid lipofuscinosis (nclf) mouse were investigated experimentally. Both models exhibit a characteristic accumulation of autofluorescent lipopigment in neuronal and non neuronal cells. The NMR profiles derived from extracts of the cortex and cerebellum from mnd and nclf mice were distinguished according to disease/wildtype status. In particular, a perturbation in glutamine and glutamate metabolism, and a decrease in {gamma}-amino butyric acid (GABA) in the cerebellum and cortices of mnd (adolescent mice) and nclf mice relative to wildtype at all ages were detected. Our results were compared to the Cln3 mouse model of NCL. The metabolism of mnd mice resembled older (6 month) Cln3 mice, where the disease is relatively advanced, while the metabolism of nclf mice was more akin to younger (1-2 months) Cln3 mice, where the disease is in its early stages of progression. Overall, our results allowed the identification of metabolic traits common to all NCL subtypes for the three animal models.

A metabolomic comparison of mouse models of the Neuronal Ceroid Lipofuscinoses

International Nuclear Information System (INIS)

Salek, Reza M.; Pears, Michael R.; Cooper, Jonathan D.; Mitchison, Hannah M.; Pearce, David A.; Mortishire-Smith, Russell J.; Griffin, Julian L.

2011-01-01

The Neuronal Ceroid Lipofuscinoses (NCL) are a group of fatal inherited neurodegenerative diseases in humans distinguished by a common clinical pathology, characterized by the accumulation of storage body material in cells and gross brain atrophy. In this study, metabolic changes in three NCL mouse models were examined looking for pathways correlated with neurodegeneration. Two mouse models; motor neuron degeneration (mnd) mouse and a variant model of late infantile NCL, termed the neuronal ceroid lipofuscinosis (nclf) mouse were investigated experimentally. Both models exhibit a characteristic accumulation of autofluorescent lipopigment in neuronal and non neuronal cells. The NMR profiles derived from extracts of the cortex and cerebellum from mnd and nclf mice were distinguished according to disease/wildtype status. In particular, a perturbation in glutamine and glutamate metabolism, and a decrease in γ-amino butyric acid (GABA) in the cerebellum and cortices of mnd (adolescent mice) and nclf mice relative to wildtype at all ages were detected. Our results were compared to the Cln3 mouse model of NCL. The metabolism of mnd mice resembled older (6 month) Cln3 mice, where the disease is relatively advanced, while the metabolism of nclf mice was more akin to younger (1-2 months) Cln3 mice, where the disease is in its early stages of progression. Overall, our results allowed the identification of metabolic traits common to all NCL subtypes for the three animal models.

Suicide in patients with motor neuron disease

DEFF Research Database (Denmark)

Bak, Søren; Stenager, E N; Stenager, Egon

1994-01-01

The aim of the present study was to assess, through an epidemiological study, whether suicide risk is increased in patients with motor neuron disease (MND). The study involved 116 patients with MND. In the study period 92 patients died, 47 males and 45 females. No patients committed suicide....... The number of expected suicides was 0.27 for males and 0.12 for females, a total of 0.38. The difference between observed and expected suicides was not statistically significant for males and females....

Viron arkkitehtuurin uudistaja = Creators of new Estonian architecture / Tarja Nurmi

Index Scriptorium Estoniae

Nurmi, Tarja

2016-01-01

KOKO arhitektuuribüroo arhitektidest Raivo Kotovist ja Andrus Kõresaarest. Tähtsamad tööd: Fahle maja, Lennusadama angaarid, äri- ja büroohoone Rotermanni kvartalis, Balti jaama turuhooned. Eesti ja Soome arhitektide koostööst

Parteilased taluvad telesaadet "Pehmed ja karvased" naerusui / Alo Lõhmus

Index Scriptorium Estoniae

Lõhmus, Alo

2002-01-01

ETV poliitilise pila nukushõu "Pehmed ja karvased" : stsenaristid Toomas Kall ja Andrus Kivirähk : idee autor, režissöör ja kunstnik Hardi Volmer : produtsent, idee autor Raivo Suviste. Kuidas hindavad seriaali poliitikud ja tavavaatajad

"Paranormalnaja" võstavka v galereje

Index Scriptorium Estoniae

2008-01-01

PARA näitus أParanormؤ Narva Muuseumi kunstigaleriis. Osalevad Ilmar Malin, Jüri Palm, Elo Järv, Vello Vinn, Leonhard Lapin, Enn Tegova, Ahti Seppet, Raivo Kelomees ja Kristina Viin. Parasürrealistide rühmitusest PARA

Kuidas lugeda "Meeste domineerimist"? / Patrick Champagne ; tlk. Marek Tamm

Index Scriptorium Estoniae

Champagne, Patrick

2005-01-01

Rets. rmt.: Bourdieu, Pierre. Meeste domineerimine. Tallinn, 2005. Kommenteerivad (lk. 12-14) Liina Lukas, Rein Ruutsoo (TLÜ õppejõud), Marina Grišakova, Aare Pilv, Airi-Alina Allaste, Raivo Vetik (TLÜ Õppejõud), Andres Härm, Voldemar Tomusk

Transcriptome profiling of Lactococcus lactis subsp. cremoris CECT 8666 in response to agmatine

Directory of Open Access Journals (Sweden)

Beatriz del Rio

2016-03-01

Full Text Available The dairy strain Lactococcus lactis subsp. cremoris CECT 8666 (formerly GE2-14 synthesizes the biogenic amine putrescine from agmatine via the agmatine deiminase (AGDI pathway [1]. The AGDI cluster of L. lactis is composed by five genes aguR, aguB, aguD, aguA and aguC. The last four genes are co-transcribed as a single policistronic mRNA forming the catabolic operon aguBDAC, which encodes the proteins necessary for agmatine uptake and its conversion into putrescine [1,2]. The first gene of the cluster, aguR, encodes a transmembrane protein that functions as a one-component signal transduction system that senses the agmatine concentration of the medium and accordingly regulates the transcription of aguBDAC [2]. The catabolic operon aguBDAC is transcriptionally activated by agmatine [2] and transcriptionally regulated by carbon catabolite repression (CCR via glucose, but not by other sugars such as lactose or galactose [1,3]. On the contrary, the transcription of the aguR regulatory gene is not subject to CCR regulation [1,3] nor is regulated by agmatine [2]. In this study we report the transcriptional profiling of L. lactis subsp. cremoris CECT 8666 grown in M17 medium with galactose (GalM17 as carbon source and supplemented with agmatine, compared to that of the strain grown in the same culture medium without agmatine. The transcriptional profiling data of agmatine-regulated genes were deposited in the Gene Expression Omnibus (GEO database under Accession no. GSE74808. Keywords: Lactococcus lactis, Biogenic amines, Putrescine, Agmatine deiminase, Agmatine

Quantification of brain metabolites in amyotrophic lateral sclerosis by localized proton magnetic resonance spectroscopy

DEFF Research Database (Denmark)

Gredal, O; Rosenbaum, S; Topp, S

1997-01-01

We performed proton magnetic resonance spectroscopy (1H-MRS) in patients with motor neuron disease (MND) to determine the absolute in vivo concentrations in the brain of the metabolites N-acetyl aspartate (NAA), choline (Cho), and creatine (Cr/PCr). We examined the spectra acquired from a 20 x 20 x...... subjects. We estimated the concentrations of the metabolites using the water signal as an internal standard. The concentrations of Cho and Cr/PCr in both brain regions, as well as the concentration of NAA in the cerebellum, were unaltered in the MND patients compared with the controls. Only MND patients...... with both upper and lower motor neuron signs had a significantly decreased concentration of NAA (9.13 +/- 0.28 mM, mean +/- SEM) in the primary motor cortex when compared with healthy controls (10.03 +/- 0.22 mM). In conclusion, the slightly decreased concentration of NAA in the primary motor cortex from...

Direct Sensing of Nutrients via a LAT1-like Transporter in Drosophila Insulin-Producing Cells

Directory of Open Access Journals (Sweden)

Gérard Manière

2016-09-01

Full Text Available Dietary leucine has been suspected to play an important role in insulin release, a hormone that controls satiety and metabolism. The mechanism by which insulin-producing cells (IPCs sense leucine and regulate insulin secretion is still poorly understood. In Drosophila, insulin-like peptides (DILP2 and DILP5 are produced by brain IPCs and are released in the hemolymph after leucine ingestion. Using Ca2+-imaging and ex vivo cultured larval brains, we demonstrate that IPCs can directly sense extracellular leucine levels via minidiscs (MND, a leucine transporter. MND knockdown in IPCs abolished leucine-dependent changes, including loss of DILP2 and DILP5 in IPC bodies, consistent with the idea that MND is necessary for leucine-dependent DILP release. This, in turn, leads to a strong increase in hemolymph sugar levels and reduced growth. GDH knockdown in IPCs also reduced leucine-dependent DILP release, suggesting that nutrient sensing is coupled to the glutamate dehydrogenase pathway.

Finger extension weakness and downbeat nystagmus motor neuron disease syndrome: A novel motor neuron disorder?

Science.gov (United States)

Delva, Aline; Thakore, Nimish; Pioro, Erik P; Poesen, Koen; Saunders-Pullman, Rachel; Meijer, Inge A; Rucker, Janet C; Kissel, John T; Van Damme, Philip

2017-12-01

Disturbances of eye movements are infrequently encountered in motor neuron diseases (MNDs) or motor neuropathies, and there is no known syndrome that combines progressive muscle weakness with downbeat nystagmus. To describe the core clinical features of a syndrome of MND associated with downbeat nystagmus, clinical features were collected from 6 patients. All patients had slowly progressive muscle weakness and wasting in combination with downbeat nystagmus, which was clinically most obvious in downward and lateral gaze. Onset was in the second to fourth decade with finger extension weakness, progressing to other distal and sometimes more proximal muscles. Visual complaints were not always present. Electrodiagnostic testing showed signs of regional motor axonal loss in all patients. The etiology of this syndrome remains elusive. Because finger extension weakness and downbeat nystagmus are the discriminating clinical features of this MND, we propose the name FEWDON-MND syndrome. Muscle Nerve 56: 1164-1168, 2017. © 2017 The Authors Muscle & Nerve Published by Wiley Periodicals, Inc.

Efficacy of kinesiology tape versus postural correction exercises on neck disability and axioscapular muscles fatigue in mechanical neck dysfunction: A randomized blinded clinical trial.

Science.gov (United States)

El-Abd, Aliaa M; Ibrahim, Abeer R; El-Hafez, Haytham M

2017-04-01

Mechanical neck dysfunction (MND), with axioscapular muscles fatigue, is highly prevalent worldwide. While postural correction is commonly used for its treatment, efficacy of kinesiology tape (KT) has received considerable attention. To determine the effectiveness of KT versus correction exercises on neck disability, and axioscapular muscles fatigue in MND patients. 46 MND patients were randomly assigned into 1 of 2 groups receiving 4 weeks treatment of either KT or correction exercises. Neck disability and axioscapular muscles fatigue as median frequency of electromyography (EMG-MF) were measured pre and post treatment. Group-by-time interaction was not significant in the multivariable test. Post hoc tests revealed that KT produced more disability reduction than the postural exercises. However, there was no significant interaction for EMG-MF. KT has been found to be more effective than postural exercises to reduce neck disability. However, both modalities have similar effects to reduce axioscapular muscles fatigue. Copyright © 2016 Elsevier Ltd. All rights reserved.

Olympic tõotab jätkuvat tõusu / Armin Karu

Index Scriptorium Estoniae

Karu, Armin, 1965-

2006-01-01

Olympic Casino suuromanik Armin Karu vastab aripaev.ee lugejate küsimustele. Vt. samas: Raivo Sormunen. Olympicust võib saada kalleim börsifirma. Diagramm: Olympic liigub turuväärtuselt juba Tallinna börsi kalliduselt teise firma kannul

Ülevaade Eesti varasest arvutikunstist / Tuuli Lepik

Index Scriptorium Estoniae

Lepik, Tuuli

2004-01-01

Eesti arvutikunsti arengust ja seda mõjutanud erinevatest nähtustest ning objektiivsetest teguritest. Ka Mall Nukke, Aavo Ermeli ja Tõnis Vindi stuudio esimestest katsetustest ning Rauno Remme, Ando Keskküla, Raivo Kelomehe ja teiste töödest

Parimatest parimad selguvad Tartus / Mariann Märtsin

Index Scriptorium Estoniae

Märtsin, Mariann

2004-01-01

Rahvusvahelise konsultatsioonifirma Hewitt Associates uuringust "Parimad tööandjad - parimad tulemused" (Best Employers - Best Results). Lisa: Uuring. Raivo Hellerma, Piret Põldre, Milvi Tepp vastavad küsimusele, miks nad osalesid tööandjate uuringus. Vt. samas: Uuringus osalesid

Lugu mehest, kes oli iseenda naine / Kaja Roomets

Index Scriptorium Estoniae

Roomets, Kaja

2008-01-01

Doug Wrighti "Ma olen iseenda naine" Endla teatris, lavastaja Tiit Palu. Esietendus 27. juunil. Lisaks saksa päritolu transvestiidist Charlotte von Mahlsdofist (1928-2002) : "Charlotte oli fenomen" ja Kati Murutari ning Raivo Järvi arvamus : "Mis tunde esietenduselt kaasa saite?"

Kõik failid on juba alla laetud! / Eve Arpo

Index Scriptorium Estoniae

Arpo, Eve

2008-01-01

Berliini iga-aastasest kunsti- ja digitaalkultuuri festivalist "Transmediale" alapealkirjaga "Conspire...", kus käsitleti privaatsuse kadumist, info vaba levikut, hirmu, kopeeritavust, unikaalsust. Võitis ameeriklaste Julia Meltzeri ja David Thorne video "Not a Matter of If but When". Raivo Kelomehe kommentaarid

Novõi bank v Estonii / Andrei Demenkov

Index Scriptorium Estoniae

Demenkov, Andrei

2008-01-01

14. märtsil avati Tallinnas Leedu ühe suurima panga Snoras Panga Eesti filiaal. Snoras Panga presidendi Raimondas Baranauskase, Eesti filiaali direktori Raivo Sule ja Eesti Panga presidendi Andres Lipstoki kommentaarid. Lisa. Diagrammid: Finantsteenuste turg seisuga 30.06.2007

Hiigelämblik kanali kohal ehk Kuidas ERMi uus hoone lõi kired lõkkele / Tarmo Michelson

Index Scriptorium Estoniae

Michelson, Tarmo, 1975-

2006-01-01

Eesti Rahva muuseumi uue hoone arhitektuurikonkursi võidutööst "Memory Field" (autorid itaalia arhitekt Dan Dorell, liibanoni arhitekt Lina Ghotmeh, jaapani arhitekt Tsuyoshi Tane). Kommenteerivad Jaanus Plaat, Tõnis Lukas, Karin Hallas-Murula, Raivo Palmaru, Laine Jänes, Marika Valk

Veri ja sitt / Raymond Whitaker

Index Scriptorium Estoniae

Whitaker, Raymond

2006-01-01

Veristest lahingutest rahvusvaheliste rahujõudude ja taliibide vahel Afganistanis Helmandi provintsis, algsest ülesehitusmissioonist on saanud sõda. Vt. samas: Kui Helmandis käisid lahingud, olid eestlased puhkusel. Priit Hõbemägi intervjuu Eesti kontingendi ülema Raivo Tammega

Therapeutical aspect of trichomoniasis

Directory of Open Access Journals (Sweden)

Vukićević Jelica

2003-01-01

Full Text Available Trichomoniasis is frequent, parasitic and sexually transmitted infection of genitourinary tract. It is treated by metronidazole (5-nitroimidazole according to protocol recommended by Center for Disease Control (CDC formerly called: Communicable Disease Center [19]. The resistance of Trichomonas vaginalis (TV strains to metronidazole (MND was described in USA in 1960, and later on in many European countries [8, 9, 10, 11, 12, 13]. In these cases, due to persistent trichomonas infection, it is necessary to repeat MND treatment with moderate modification of dose and/or length of its application. Nevertheless, oncogenic and toxic effects of MND have to be taken into consideration. OBJECT The aim of this study was to investigate and analyze the incidence of TV in STD and lower susceptibility of certain TV strains to MND were analyzed. MATERIAL AND METHODS In three-year period (1999-2001 612 patients (244 females and 368 males suspected of STD were examined clinically and microbiologically at the Institute of Dermatovenereology in Belgrade. The patients detected for TV were treated according to CDC protocol. The affected were considered cured if there was no manifest clinical infection, and no TV verified by microbiological test. Results TV was isolated in 216 patients (35.29 % of all subjects. Trichomonas infection was found in 90 (36.88 % out of 244 tested females and in 126 (32.34 % of 368 males. Clinically manifested infection, with extensive urethral and vaginal secretion, was recorded in 161 patients, while the asymptomatic form was found in 55 subjects. This result indicates the predominance of manifested trichomonas infections (75.54 % of cases. The difference of distribution of clinical forms of trichomoniasis, in relation to sex, was not statistically significant (c2=0.854; p>0.05. The patients with verified trichomonas infection were treated by metronidazole according to CDC protocol. The recommended therapeutical scheme consisted of three

Pädevuskeskne õpe / Dirk van Vierssen

Index Scriptorium Estoniae

Vierssen, Dirk van

2002-01-01

Eestis korraldatakse politseikoolitust ümber. Konsultandiks on Hollandi Politseikoolituse Keskuse spetsialist, kasvatusteaduste doktor Dirk van Vierssen. Reformi sisu on üleminek kvalifikatsioonikeskselt õppelt pädevuskesksele (kompetentsusele põhinevale) õppele. Kvalifikatsioonikeskse ja pädevuskeskse õppe erinevusi / lindilt üles kirjutanud Raivo Juurak

Prantslased otsisid eestlaste juurest virmalisi / Henry Schmidt

Index Scriptorium Estoniae

Schmidt, Henry

2002-01-01

XI Põhjamaade kultuurifestival "Les Boréales" Prantsusmaal Caenis kutsus peakülaliseks Eesti. Eesti kunsti esindanud Raivo Kelomees Tartu Kõrgema Kunstikooli ja Jaan Toomik EKA üliõpilastega näitasid oma videokunsti, Liina Siibi näitus oli Alam-Normandia kunstikeskuses

Jagati džässiauhindu

Index Scriptorium Estoniae

2010-01-01

Jazzkaare raames 28. aprillil toimunud Eesti džässiauhindade väljaandmisest. Eesti džässiauhind määrati Raivo Tafenaule, noore džässitalendi auhind anti Peedu Kassile, džässiedendaja auhind Boris Paršinile

EXPO 2000 : Eestit müüb ekstravagantne arhitektuur ja tühjus / Heie Treier

Index Scriptorium Estoniae

Treier, Heie, 1963-

1999-01-01

Võimalustest müüa Eestit näitusel EXPO 2000 Hannoveris. Eesti paviljonist, mida projekteeritakse Eesti paviljoni arhitektuurikonkursil II kohta jaganud Raivo Kotovi ja Andrus Kõresaare kavandi järgi. Arhitektuurivõistluse kavandid on väljas Rotermanni soolalaos 22. aug.-ni.

SAS üritab panna riiki lennufirma aktsiaid müüma / Lemmi Kann

Index Scriptorium Estoniae

Kann, Lemmi

2007-01-01

SAS-i eesmärgiks on saada enamusosalus nii Estonian Airis kui ka airBalticus, et seeläbi oma positsioone Baltimaades kinnistada. Diagramm: Estonian Airi majandusnäitajad ja omanikud. Vt. samas: SAS on Estonian Airi jahtinud kaua. Kommenteerib Raivo Vare

Eesti interjöörileiud

Index Scriptorium Estoniae

2007-01-01

Tutvustatakse Ameerika moodi Mack-restorani Tartu maanteel - sisearhitekt Hillar Mänd koostöös restorani juhi Paul Lepikuga ja Arensburgi hotelli Kuressaares - arhitekt Margit Kärner koostöös Raivo Kotovi ja Lea Laidraga, sisearhitektid Liis Murula ja Raili Paling

Hea õpetamise grandi saajad

Index Scriptorium Estoniae

2016-01-01

Õpetamise uurimist alustavad grandi toel Andrus Org, Riina Oruaas, Natalja Zagura (humanitaar- ja kunstide valdkond), Stefano Braghiroli, Aet Kiisla, Tiiu Taur (sotsiaalteadused), Marje Oona, Oivi Uibo, Daisy Volmer (meditsiinitead.), Svetlana Ganina, Natalja Lepik ja Raivo Raid (loodus- ja täppistead.)

Festivalitiine september / Raivo Kelomees

Index Scriptorium Estoniae

Kelomees, Raivo, 1960-

1999-01-01

Võrreldakse sept.-s 1999 toimunud 'Ars Electronica' 20. festivali 'Life-Science' Linzis ning 4. Spliti uue filmi ja video festivali Horvaatias. Peapreemiad Linzis: netikategooria - L. Torvals, interaktiivne kunst - L. Hershmann, arvutianimatsioon - C. Wedge. Spliti festivalil esinesid Eestist T. Johanson, M. Rand, J. Kilmi, R. Kelomees. R. Kelomehe CD-ROM "tokyocity.ee" eksponeerus 'Ars Electronica' mediateegis, hiljem Splitis. Järgneb Sirp, 1999, 19. nov., lk. 8. Ilmunud ka kogumikus "Ekraan kui membraan". Tartu, 2007, lk. 76-80 pealkirja all "Festivalirikas september"

BaMa / Raivo Juurak

Index Scriptorium Estoniae

Juurak, Raivo, 1949-

2002-01-01

Eesti ülikoolide üleminekust 3+2 süsteemile. Lühend BaMa on tulnud kasutusele seoses Euroopa ülikoolide õppekavade reformimisega ning tähistab õppekava, kus esimese astme läbimise järel omandatakse bakalaureuse- ja teise järel magistrikraad. Õppekavade tüüpidest Eesti ja Euroopa Liidu kõrgkoolides ning Bologna deklaratsioonist

Poolaasta meediafestivalid / Raivo Kelomees

Index Scriptorium Estoniae

Kelomees, Raivo, 1960-

2000-01-01

Stuttgardi festivalist "13. Filmwinter", näitusest ja konverentsist "Alien Intelligence" Helsingis "Kiasmas" (kuraator Erkki Huhtamo), Lissaboni videofestivalist "Videolisboa", Moskva "Pro & Contra" konverentsist (Eestist esines netiprojektiga "Get.real" Tiia Johannson), Kiievi videokunsti ja lühifilmide festivalist "Dreamcatcher". Ilmunud ka kogumikus "Ekraan kui membraan". Tartu, 2007, lk. 88-91

New support line for members

Science.gov (United States)

AGU has recently established a new customer "support line"—solutions@agu.org—as the point of contact on AGU's staff for members and other individual constituents who have not been able to resolve issues or get questions answered promptly or to their satisfaction through customary channels.Over the past year, there have been many changes at AGU. Unfortunately—and perhaps as a result of these changes—communication with members and individual constituents has suffered. Some individuals report, for example, that e-mail messages are not answered to their satisfaction, or in a timely manner. Instructions on AGU's Web site are unclear in some areas. Problems related specifically to the transition to electronic publishing are cropping up.

Meediakunsti "olümpiamängud"

Index Scriptorium Estoniae

2000-01-01

7.-10. XII toimus Pariisis X rahvusvaheline elektroonilise kunsti sümpoosion "Révélation". Eestist esinesid Raivo Kelomees CD-ROM-projektidega "tokyocity.ee" ja "Videoweaver", Tiia Johannson netiprojektiga "Skyscraper.net". Mare Tralla esines Iliyana Nedkova koostööprojekti "Virtual Revolutions" raames.

Lahkus juhmi Hundi ja kavala Jänese looja / Andri Maimets, Marko Lillemägi

Index Scriptorium Estoniae

Maimets, Andri, 1979-

2006-01-01

Suri vene animakunstnik, kuulsate tegelaskujude - Hundi ja Jänese looja joonisfilmisarjas (1969-1986) "Oota sa!" ("Nu, pogodi!") Svetozar Russakov (sünd. 3.04.1923). Filmi omaaegset mõju meenutab Rein Raamat. Kommenteerivad Raivo Järvi, Hendrik Normann, Ain Nurmela, Marika Korolev, Evelin Samuel

Palmaru vrutshil Sashe Pepeljajevu orden / Esme Kassak, Anu Aaremäe

Index Scriptorium Estoniae

Kassak, Esme

2006-01-01

Kultuuriminister Raivo Palmaru andis Von Krahli Teatris pärast "Võluflöödi" etendust vene koreograafile, tantsijale ja lavastajale Sasha Pepeljajevile Maarjamaa Risti viienda järgu ordeni. "Võluflöödi" tantsuline osa sündis S. Pepeljajevi käe all

Hansapanga aktsia vastu ostuhuvi raugenud / Annika Matson

Index Scriptorium Estoniae

Matson, Annika, 1976-

2004-01-01

Analüütikud soovitavad Hansapanga aktsiat ostmise asemel hoida. Graafikud: Kümnekordne võit; Aktsia hind järgib ING soovitusi. Vt. samas: ING on seni oma prognoosidega Hansapanga aktsia trendi loonud. Raivo Sormunen. Hansapanga aktsia on julgest investeerijast teinud miljonäri;

TÜ Loodusmuuseum = University of Tartu Natural History Museum / Raili Paling, Liis Lindvere, Kadri Kaldam ; kommenteerinud Jana Lass

Index Scriptorium Estoniae

Paling, Raili

2016-01-01

Tartu Ülikooli Loodusmuuseumi (Tartu, Vanemuise tn. 46) interjöör ja ekspositsioon. Autorid Jelena Altmäe, Kadri Kaldam, Raivo Kotov, Andrus Kõresaar, Lea Laidra, Liis Lindvere, Indrek Mikk, Jaanus Männik, Raili Paling; projektijuht Reet Mägi; kuraatorid Kaie Kotov, Riste Keskpaik

Kas presidenti tohib narrida?

Index Scriptorium Estoniae

2002-01-01

ETV poliitilise pila nukushõu "Pehmed ja karvased" : stsenaristid Toomas Kall ja Andrus Kivirähk : idee autor, režissöör ja kunstnik Hardi Volmer : produtsent, idee autor Raivo Suviste. Kuidas hindavad tulemust ekraanil stsenaristid Andrus Kivirähk ja Toomas Kall

Anu Lamp, Tõnu Oja ja Jan Uuspõld uues pilasaates / Heili Sibrits

Index Scriptorium Estoniae

Sibrits, Heili, 1977-

2001-01-01

ETV eetrisse jõuab aasta viimase päeva õhtul esimene osa uuest poliitilise pila nukushõust "Pehmed ja karvased" : stsenaristid Toomas Kall ja Andrus Kivirähk : idee autor, režissöör ja kunstnik Hardi Volmer : produtsent, idee autor Raivo Suviste

Lennusadam = Seaplane Harbour / Andrus Kõresaar

Index Scriptorium Estoniae

Kõresaar, Andrus, 1975-

2013-01-01

Tallinna Lennusadama vesilennukite angaaride rekonstrueerimisest, Eesti Meremuuseumi uue ekspositsiooni kujundusest. Autorid: Andrus Kõresaar, Olga Batuhtina, Raivo Kotov, Margit Argus, Margit Aule, Indrek Mikk (KOKO Arhitektid). Insener Karl Õiger. Arhitektuuriajaloolase Mart Kalmu ning arhitektuurikriitiku ja ESLi aastapreemiate žürii liikme Triin Ojari arvamused

Meediakunst möllab küberkohvikus

Index Scriptorium Estoniae

1999-01-01

2. offline@online meediakunsti festival 24. ja 25. XI Eesti Kunstiakadeemias küberkohvikus 'Enter'. Esitatakse ligi saja kunstniku CD-ROMe, internetiprojekte ja videosid. Alajaotuses 'Media Non Grata' sektsioon nn low-tech meedia eksponeerimiseks. Osalejaid. Kataloogis Raivo Kelomehe sisasejuhatav tekst 'Nurgakunst ئ Media Non Grata'.

Lummav Reeves lisas Jazzkaarele sära / Mirje Mändla

Index Scriptorium Estoniae

Mändla, Mirje

2010-01-01

21. festivalist Jazzkaar, Dianne Reevesi kontserdist, mille raames toimus Eesti džässiauhindade väljaandmine. Eesti džässiauhinna pälvis Raivo Tafenau, noore džässitalendi auhind anti Peedu Kassile, džässiedendaja auhind Boris Paršinile

Loomad räägivad sel korral eesti keeles / Jaanus Noormets

Index Scriptorium Estoniae

Noormets, Jaanus

2008-01-01

Arvutiga animeeritud USA koguperefilmist "Madagaskar 2" (Madagascar: Escape 2 Africa), mis jõuab Eesti kinodesse erinevalt filmisarja esimesest osast eesti keelde dubleerituna (loomtegelastele on oma hääle laenanud Karol Kuntsel, Andero Ermel, Evelin Pang, Mait Malmsten, Raivo E. Tamm, Andrus Vaarik jt)

Mängud ja koostöö = Games and collaboration / Oliver Laas

Index Scriptorium Estoniae

Laas, Oliver, 1985-

2015-01-01

Mari Prekupi, Ott Jesseri, Raivo Kelomehe, James Connori, Sven Pärteli ja Johann Taeli ühisnäitusest "Elektra 2015" Tallinna Linnagaleriis. Enamik eksponeeritud töödest on mängud, mis vajavad aktiveerimiseks näitusekülastajate koostööd

Prediction of cleavage crack propagation and arrest in a nuclear pressure vessel steel (16MND5) under thermal shock

International Nuclear Information System (INIS)

Yang, Xiaoyu

2015-01-01

The purpose of this PhD study is to predict the propagation and arrest of cleavage cracks in a French PWR vessel steel (16MND5). This is accomplished through use of a local criterion based on the critical stress calculated ahead of crack tip. Previous work has shown that fracture mechanism was cleavage associated with the ductile shear zone between the different planes of cracking. Thus, the critical stress at crack tip depends on stain rate. This thesis consists of numerical optimization, identification and validation of a local criterion based on experiments which have complex thermomechanical loads. The criterion accounts for various crack paths, deepening the knowledge about micro mechanisms during crack propagation in order to justify the established criterion. Criterion identification was carried out by using numerical simulations of tension tests performed on CT (Compact Tension) specimens at four different temperatures (-150 C, -125 C, -100 C and -75 C). The eXtended Finite Element Method (X-FEM) was used in CAST3M FE software to model dynamic crack propagation and arrest. The analysis results in 2D and 3D showed that the critical stress at crack tip increased with the inelastic strain rate. Therefore, a criterion based on the critical stress was established. An analytical model was developed to justify the identified criterion. The critical stress given by the local criterion was considered as the sum of the critical cleavage stress and the stress generated by the deformation of ligaments behind the crack tip. In order to quantify this phenomenon, measurements of ligaments' characteristics have been performed on fracture surfaces and on cross-sections of the specimens. The stress profile of the crack lips generated by ligaments was calculated by modeling of multi-cracks on specimen's cross-section. The contribution of stress generated by ligaments to the critical stress at crack tip was obtained with this method, and then the analytical model of

Voltage-Gated Potassium Channel Antibodies in Slow-Progression Motor Neuron Disease.

Science.gov (United States)

Godani, Massimiliano; Zoccarato, Marco; Beronio, Alessandro; Zuliani, Luigi; Benedetti, Luana; Giometto, Bruno; Del Sette, Massimo; Raggio, Elisa; Baldi, Roberta; Vincent, Angela

2017-01-01

The spectrum of autoimmune neurological diseases associated with voltage-gated potassium channel (VGKC)-complex antibodies (Abs) ranges from peripheral nerve disorders to limbic encephalitis. Recently, low titers of VGKC-complex Abs have also been reported in neurodegenerative disorders, but their clinical relevance is unknown. The aim of the study was to explore the prevalence of VGKC-complex Abs in slow-progression motor neuron disease (MND). We compared 11 patients affected by slow-progression MND with 9 patients presenting typical progression illness. Sera were tested for VGKC-complex Abs by radioimmunoassay. The distribution of VGKC-complex Abs was analyzed with the Mann-Whitney U test. The statistical analysis showed a significant difference between the mean values in the study and control groups. A case with long-survival MND harboring VGKC-complex Abs and treated with intravenous immunoglobulins is described. Although VGKC-complex Abs are not likely to be pathogenic, these results could reflect the coexistence of an immunological activation in patients with slow disease progression. © 2016 S. Karger AG, Basel.

Attitudes towards euthanasia and physician-assisted suicide among Pakistani and Indian doctors: A survey

Directory of Open Access Journals (Sweden)

Syed Qamar Abbas

2008-01-01

Full Text Available Aim: This study attempts to assess the attitude of Pakistani and Indian doctors to euthanasia and physician-assisted suicide. Methods: We used a questionnaire survey that included one case history of a patient with cancer and another of one suffering from motor neurone disease (MND. Results: Fifty-two of 100 doctors from Pakistan returned the completed questionnaires. Eight of the 52 (15.3% doctors agreed with the concept of euthanasia being an acceptable option for the patient with MND. Six of the 52 (11.5% supported a similar approach for the cancer patient. From India, 60/100 doctors returned the completed questionnaires. Sixteen of the 60 (26.6% doctors supported euthanasia as an option for the patient with MND whereas 15 (25% supported a similar option for the cancer patient. Conclusion: We conclude that only a minority of the doctors support euthanasia. This group belongs to a younger age group. In Pakistan, they were more likely to be males. The religion of the doctors did not appear to be a determining factor.

Tänane Tartu - naerud, nutud ja hernetondid = Tartu today - laughter, tears and scarecrows / Berk Vaher

Index Scriptorium Estoniae

Vaher, Berk, 1975-

2006-01-01

Tartu linnaruumist, selle teisenemistest. Eduard Tubina mälestusmärgist (skulptor Aili Vahtrapuu, arhitekt Veronika Valk, heli: Louis Dandrel), Tartu Kaubamajast (arhitekt Raivo Puusepp), Rüütli tänava kujundusest (Rene Valner, Ott Kadarik), Ülikooli tänavast. 5 värv. ill

Наши - в финале "архитектурного Оскара" / Нина Рачинская

Index Scriptorium Estoniae

Рачинская, Нина

2009-01-01

Euroopa Liidu Mies van der Rohe nimelisest kaasaegse arhitektuuri preemiast. 2009. a. võitjaks tuli Oslo ooperi- ja balletiteater (arhitektuuribüroo Snohetta). Eesti töödest valiti kataloogi KOKO Arhitektide Andrus Kõresaare ja Raivo Kotovi projekteeritud Tallinna Rotermanni kvartali laudsepatöökoja rekonstruktsioon

Aasta koolitaja Svetlana Moks : "Iga inimese elus on sündmusi, mille tähtsus selgub alles hiljem" / Svetlana Moks ; interv. Tiia Linnard

Index Scriptorium Estoniae

Moks, Svetlana

2005-01-01

Ilmunud ka: Severnoje Poberezhje : Subbota 24. september lk. 3. Tänavu aasta Eesti parim koolitaja töötab Eesti Põlevkivi koolitusjuhina. Svetlana Moksi CV. Arvamust avaldavad A-i Eesti Põlevkivi avalike suhete juht Raivo Lott ja AS-i Eesti Põlevkivi juhatuse liige, administratsioonidirektor Lembit Kaljuvee

Suvehooaeg Emajõe Ateenas liidab lugusid mitmest sajandist / Raimu Hanson

Index Scriptorium Estoniae

Hanson, Raimu, 1957-

2006-01-01

Tartu suvelavastustest : Urmas Lennuki "Koidula" Andres Dvinjaninovi lavastuses (Emajõe Suveteater) ; Jan Rahmani "Sõit" Ain Mäeotsa lavastuses (Hansahoovi Teater), Raivo Adlase lavastus "Vaesed ja patused" August Jakobsoni ainetel Tartu raudteejaamas (Vilde Teater), G. Bizet' "Carmen" Ago-Endrik Kerge lavastuses (Muusikaline loomeühendus KaivConsort)

Suvelavastuste hooaeg Tartus liidab endasse lugusid mitmest sajandist / Raimu Hanson

Index Scriptorium Estoniae

Hanson, Raimu, 1957-

2006-01-01

Tartu suvelavastustest : Urmas Lennuki "Koidula" Andres Dvinjaninovi lavastuses (Emajõe Suveteater) ; Jan Rahmani "Sõit" Ain Mäeotsa lavastuses (Hansahoovi Teater), Raivo Adlase lavastus "Vaesed ja patused" August Jakobsoni ainetel Tartu raudteejaamas (Vilde Teater), G. Bizet' "Carmen" Ago-Endrik Kerge lavastuses (Muusikaline loomeühendus KaivConsort)

Rae vald peab arendajatega kümnisesõda / Ralf-Martin Soe

Index Scriptorium Estoniae

Soe, Ralf-Martin

2008-01-01

Rae valla kinnisvaraarendajad sõdivad kohtu abil vallavalitsuse küsitava peamaksu vastu. Vt. samas: Volikogulasel sujub arendamine kui lepase reega; Ka teised vallad nõuavad investeeringuid sotsiaalobjektidesse. Kommenteerib Saue vallavanem Mati Tartu. Vt. ka vastuseks Raivo Uukkivi art. 31. jaan. Äripäev lk. 23

Kalev ja Rae vald tülitsevad tehase reovee pärast / Garel Püüa

Index Scriptorium Estoniae

Püüa, Garel

2006-01-01

Kalevi kommivabriku heitvee reostustase ületab kohati kümme korda tehase ehitamisel taotletud taset, Rae valla veepuhasti ei suuda nii suurt koormust taluda. Kalevi õigusteeninduse juhi Allan Viirma sõnul ei ole vald väljastanud Kalevile reovee eelpuhastite rajamiseks projekteerimistingimusi. Kommenteerib Rae vallavanem Raivo Uukkivi

Tallinna Teletorn = Tallinn Television Tower

Index Scriptorium Estoniae

2015-01-01

Rekonstrueeritud Tallinna Teletorn Kloostrimetsa tee 58a, valminud 2012. Eesti kultuurkapitali aastapreemia 2012. Arhitekt David Basiladze. Rekonstrueerimise projekti arhitektid Raivo Kotov, Andrus Kõresaar, Indrek Mikk, Margit Aule, Jaanus Männik, Lea Laidra, Karis Kahr (KOKO Arhitektid). Sisearhitektid Liis Lindvere, Raili Paling, Margit Argus (KOKO Arhitektid). Konstruktor Neoprojekt

Jõhvis tuleb parasürrealistide näitus

Index Scriptorium Estoniae

2008-01-01

Jõhvi kontserdimajas avatakse parasürrealistide rühmituse PARA näitus "Panoraam". Osalevad Ilmar Malin (maalid), Jüri Palm (maalid), Elo Järv (nahkskulptuurid), Vello Vinn (graafika), Leonhard Lapin (akvarellid), Enn Tegova (maalid), Ahti Seppet (puuskulptuurid), Raivo Kelomees (maalid), Kristiina Viin (joonistused ja maalid)

Büroohoone-elamu. Tallinn, J. Vilmsi 5/Raua 36 / Piret Lindpere, Andres Kurg

Index Scriptorium Estoniae

Lindpere, Piret, 1963-

1997-01-01

Kuuekorruselise hoone I korrusel on äriruumid, II-III korrusel kontorid, IV-VI korrusel korterid. Välisviimistlusest. Peatöövõtja : AS FCM. Projekt : Arhitektibüroo R. Puusepp, 1996. Arhitekt Raivo Puusepp. Konstruktsioon : Neoprojekt. Eriosad : Projektkeskus. Välisseinte kattematerjal : Avesta Sheffield Eesti OÜ. Valmis 1997

A self-care, problem-solving and mindfulness intervention for informal caregivers of people with motor neurone disease: A pilot study.

Science.gov (United States)

Ugalde, Anna; Mathers, Susan; Hennessy Anderson, Nicole; Hudson, Peter; Orellana, Liliana; Gluyas, Cathy

2018-04-01

Informal caregivers of people with motor neurone disease (MND) take on an extensive role. Caregivers are at increased risk of experiencing psychological distress and burden, yet, there is a lack of intervention programmes to support them. The aim of this study was to investigate the feasibility and acceptability of a therapeutic group intervention promoting self-care, problem-solving and mindfulness to informal caregivers of people with MND. Pilot study that utilised a one-arm pre- and post-design. Acceptability of the intervention was assessed 2 weeks post intervention with a questionnaire designed specifically for this study. Feasibility was assessed with consent, adherence and reasons for non-participation, refusal and attrition. Participants completed baseline and follow-up (6-week post intervention) questionnaires for psychological morbidity, burden, problem-solving, mindfulness and preparedness. Settings/participants: Caregivers of people with a diagnosis of MND within the past 12 months who were 18 years or older; who could speak, read and write in English and who were attending a progressive neurological diseases clinic were eligible. A total of 13 caregivers participated in one of three group intervention sessions which were focused on self-care, problem-solving and mindfulness. The intervention appeared to be feasible and acceptable. All participants stated that they would recommend the intervention to others. The group format appeared to be highly valued. There was no significant change in measures between pre-intervention and 6 weeks post intervention. This pilot serves as an initial step for examining interventions for MND caregivers, with the hope of identifying effective, efficient and sustainable strategies to best support this group.

Predictive value of general movements' quality in low-risk infants for minor neurological dysfunction and behavioural problems at preschool age.

Science.gov (United States)

Bennema, Anne N; Schendelaar, Pamela; Seggers, Jorien; Haadsma, Maaike L; Heineman, Maas Jan; Hadders-Algra, Mijna

2016-03-01

General movement (GM) assessment is a well-established tool to predict cerebral palsy in high-risk infants. Little is known on the predictive value of GM assessment in low-risk populations. To assess the predictive value of GM quality in early infancy for the development of the clinically relevant form of minor neurological dysfunction (complex MND) and behavioral problems at preschool age. Prospective cohort study. A total of 216 members of the prospective Groningen Assisted Reproductive Techniques (ART) cohort study were included in this study. ART did not affect neurodevelopmental outcome of these relatively low-risk infants born to subfertile parents. GM quality was determined at 2 weeks and 3 months. At 18 months and 4 years, the Hempel neurological examination was used to assess MND. At 4 years, parents completed the Child Behavior Checklist; this resulted in the total problem score (TPS), internalizing problem score (IPS), and externalizing problem score (EPS). Predictive values of definitely (DA) and mildly (MA) abnormal GMs were calculated. DA GMs at 2 weeks were associated with complex MND at 18 months and atypical TPS and IPS at 4 years (all ppredictive value of DA GMs at 2 weeks were rather low (13%-60%); specificity and negative predictive value were excellent (92%-99%). DA GMs at 3 months occurred too infrequently to calculate prediction. MA GMs were not associated with outcome. GM quality as a single predictor for complex MND and behavioral problems at preschool age has limited clinical value in children at low risk for developmental disorders. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Numerical modelling of Charpy-V notch test by local approach to fracture. Application to an A508 steel in the ductile-brittle transition range; Modelisation de l'essai Charpy par l'approche locale de la rupture. Application au cas de l'acier 16MND5 dans le domaine de transition

Energy Technology Data Exchange (ETDEWEB)

Tanguy, B

2001-07-15

Ferritic steels present a transition of the rupture mode which goes progressively of a brittle rupture (cleavage) to a ductile rupture when the temperature increases. The following of the difference of the transition temperature of the PWR vessel steel by the establishment of toughness curves makes of the Charpy test an integrating part of the monitoring of the French PWR reactors. In spite of the advantages which are adapted to it in particular its cost, the Charpy test does not allow to obtain directly a variable which characterizes a crack propagation resistance as for instance the toughness used for qualifying the mechanical integrity of a structure. This work deals with the establishment of the through impact strength-toughness in the transition range of the vessel steel: 16MND5 from a non-empirical approach based on the local approach of the rupture. The brittle rupture is described by the Beremin model (1983), which allows to describe the dispersion inherent in this rupture mode. The description of the brittle fissure is carried out by the GTN model (1984) and by the Rousselier model (1986). This last model has been modified in order to obtain a realistic description of the brittle damage in the case of fast solicitations and of local heating. The method proposed to determine the parameters of the damage models depends only of tests on notched specimens and of the inclusion data of the material. The behaviour is described by an original formulation parametrized in temperature which allows to describe all the tests carried out in this study. Before using this methodology, an experimental study of the behaviour and of the rupture modes of the steel 16MND5 has been carried out. From the toughness tests carried out in quasi-static and dynamical conditions, it has been revealed that this steel does not present important unwedging of its toughness curve due to the velocity effect. In the transition range, local heating of about 150 C have been measured in the root

Molecular nonlinear dynamics and protein thermal uncertainty quantification

Science.gov (United States)

Xia, Kelin; Wei, Guo-Wei

2014-01-01

This work introduces molecular nonlinear dynamics (MND) as a new approach for describing protein folding and aggregation. By using a mode system, we show that the MND of disordered proteins is chaotic while that of folded proteins exhibits intrinsically low dimensional manifolds (ILDMs). The stability of ILDMs is found to strongly correlate with protein energies. We propose a novel method for protein thermal uncertainty quantification based on persistently invariant ILDMs. Extensive comparison with experimental data and the state-of-the-art methods in the field validate the proposed new method for protein B-factor prediction. PMID:24697365

运动神经元病%Motor Neuron Disease

Institute of Scientific and Technical Information of China (English)

蒋雨平

2014-01-01

Motor neuron disease (MND) represents a group of sporadic or genetic neurodegenerative diseases which principally affect the motor neurons and result in progressive paralysis and death. The epidemiology, genetics, clinical manifestation, diagnostic criteria of MND were reviewed.%运动神经元病是一组散发或遗传的神经变性病。主要累及运动神经元，病程进展而死亡。文中就其临床表现和诊断标准、流行病学和遗传学进行综述。

19. novembril avati Eesti Kunstiakadeemia aulas...

Index Scriptorium Estoniae

1998-01-01

Prantsusmaa, Balti- ja Põhjamaade video ja uue meedia festival "offline@online". Festivali osad : videod ja eksperimentaalne film ning online-videod, võrguprojektid, CD-ROMid. Osa võtavad rahvusvaheliselt tuntud kunstnikud ja lektorid. Üldkuraator Raivo Kelomees, võrguprojektide kuraator Tiia Johannson. Ürituste kava 20. ja 21. novembril.

Koolijuhtide aastakonverents peetakse Pärnus / Martin Kaasik, Jaan Reinson, Raimu Pruul ... [jt.] ; intervjueerinud Ülo Tikk

Index Scriptorium Estoniae

2007-01-01

Eesti Koolijuhtide Ühenduse 17. aastakonverentsist teemal "Õppiv koolijuht". Küsimustele vastavad direktorid: Martin Kaasik (Tallinna Laagna Gümnaasium, Eesti Koolijuhtide Ühenduse üks asutaja), Jaan Reinson (Tartu Descartes'i Lütseum), Raimu Pruul (Häädemeeste Keskkool), Raivo Heinaru (Kohila Gümnaasium), Senta Room (Muhu Põhikool)

Rotermanni laudsepatöökoda = Rotermann carpenter's workshop / Margit Mutso

Index Scriptorium Estoniae

Mutso, Margit, 1966-

2010-01-01

Tallinnas Roseni 7 asuva laudsepatöökoja kaasajastamisest. Arhitektid: Andrus Kõresaar, Raivo Kotov (KOKO Arhitektid). Žürii liikme Kalle Komissarovi hinnang kultuurkapitali aastapreemiale esitatud hoonele. Laudsepatöökoda esitati Mies van der Rohe arhitektuuripreemia kandidaadiks ja žürii valis selle oma valiknäitusele

Punane moon või kaine mõistus / Ene Läkk

Index Scriptorium Estoniae

Läkk, Ene, 1957-

2001-01-01

Nukuteatri uue hoone sisekujunduse võistluse I ja II koha töödest. I koha töö autorid Raivo Kotov ja Andrus Kõresaar, II koha töö autorid Ülar Mark, Liina Link, stilist Ain Nurmela ja arvutigraafik Tanel Viks büroost Mark & Tamm Arhitektid

IV rahvusvaheline turismikonverents "Ma armastan Eestimaad!"

Index Scriptorium Estoniae

2009-01-01

25. septembril Meriton Conference&Spa Hotellis toimunud turismikonverentsist Lühiülevaade Juhan Partsi, Maria Alajõe, Paul Flattersi, Gerald Broddelezi, Raul Rebase, Raivo Vare, Birgit Prikki, Mikko Fritze, Andres Toode, Merle Adamsi ja Helen Mahmastoli ettekannetest, konverentsi moderaator oli Eesti Kaubandus- ja Tööstuskoja peadirektor Siim Raie

Veskitammi kortermaja : ridaelamu Laagris Urva tn. 7 = Veskitammi Apartment Building : Row House in Laagri,Urva Str. 7

Index Scriptorium Estoniae

2002-01-01

Projekteerija: COO Arhitektid. Autorid Ott Kadarik, Mihkel Tüür. Konstruktsioonid: Leo Lipre. Projekt 2001, hoone valmis 2002. Maja aluseks oli Raivo Puusepa projekteeritud ridamaja keldrikorrus. Hoone on kaetud laudisega, igas korteris on kamin ja saun, maja taga on aed. 7 ill.: II korruse plaan, välisvaated

Policy Statements Issued by Scientific Societies: Why Less can be More

Science.gov (United States)

Folger, P. F.

2001-12-01

The results of hydrological research are increasingly important to decision-makers grappling with problems as diverse as global climate change, non-point source pollution, extreme weather events, and damage from flooding. In some cases scientific aspects of these problems are interwoven with economic, political and social disputes, and policy makers often seek the consensus scientific opinion to help shape the debate. Policy or position statements issued by scientific societies like AGU can embody scientific consensus and thus inform the public and policy makers. But this is not always the case. The potential for creating public misunderstanding is ever present. Therefore, the process leading to a policy statement needs to be deliberative, inclusive to the extent possible, and circumspect. In contrast to advocacy organizations or trade groups, as a learned society AGU and members acting on its behalf should only advocate positions on political or social issues that are based solely on available geophysical data and recognized scientific debate. That does not mean that AGU and other scientific societies must refrain from entering a political debate. AGU has a responsibility to its members to adopt positions of advocacy on geophysical science issues based on their intrinsic merits and needs. However, a learned society like AGU should state only what is credible about the scientific aspects of a political debate and not overstep its authority as an objective source of analysis and commentary for the geophysical sciences. Before adopting an advocacy position, AGU's volunteers follow a process that includes checks and balances so that the final statement is based on sound scientific issues and reflects the interests of the Union as a whole. Any AGU member or committee can propose a position statement, but the Committee on Public Affairs (COPA) decides whether the proposal fall within the guidelines for advocacy. If it does and if COPA considers the issue worthy of an

Nullpunkti kerkib eliitklassi ärihoone / Lauri Leet

Index Scriptorium Estoniae

Leet, Lauri

2008-01-01

Tallinnas 2007. a. sügisest käiva Metro Plaza ärihoone ehitust tutvustab projektijuht Kuldar Gil. Vastavalt muinsuskaitselistele nõudmistele säilitati vana hoone fassaadiosa. Hoone klaasfassaadi valguskujundusest. Ehitab Facio Ehituse AS. Arhitektuurne projekt: KOKO Arhitektid OÜ. Konstruktiivse osa projekteerija: Neoprojekt. Hoone kavandamist tutvustab arhitekt Raivo Kotov

Muusikapassioon mõttepeeglis. Täna kõlab "Stabat Mater" / Anne Peäske

Index Scriptorium Estoniae

Peäske, Anne, 1946-

2005-01-01

Arvo Pärdi "Passio" ettekandest 11.sept. Rakvere Kolmainu kirikus. Elmo Lööve, Raivo Palmaru, Jaan Rääts, Toivo Tulev, Aarne Talvik, Ingmar Kurg, Olev Oja ja Eleonora Pärt Arvo Pärdi muusikast. A. Pärdi "Stabat Mater" ansambli Theatre of Voices esituses 14. sept. Rakvere Kolmainu kirikus

Parimad näidendid 2003 Unduskilt ja Lennukilt / Neeme Korv

Index Scriptorium Estoniae

Korv, Neeme, 1974-

2003-01-01

I preemia: Urmas Lennuk "Boob teab", Jaan Undusk "Quevedo"; II preemia: Anu Allas "Lendav rõdu ehk Nagu nad tahtsid", Raivo Kütt "Papa (Sõtse ja venna)"; III preemia Jakob Karu "Asjade seis", Hans Nordberg "aaron : juuni"; ergutuspreemia: Urmas Lennuk "Kadunud kindapood", Urmas Vadi "Kadunud kosmoses", Jaan Võõramaa "Mamma";

Põimunud ajastud vanalinnakodus / Helle Neemre

Index Scriptorium Estoniae

Neemre, Helle

1998-01-01

Kaasajastatud vanalinnakorter Väike-Karja tänavas. Muljeid ja meenutusi tehtust sisekujundaja Helle Neemrelt. Pildiallkirjad - Jüri Kuuskemaa. Korterist võib leida Hansa-aegseid detaile, regionalistlikku laadi, moodsaid mugavusi kaasaegses kujunduses. Sepised (kardinapuud, trepikäsipuu, kaminariistad, -rest) - sepp Raivo Uus. Paekivist detailid restaureeris KAR Grupp. Diivan ja laud - Mang.

Kuhu investeerida ettevõtte müügiga teenitud raha? / Peeter Raidla

Index Scriptorium Estoniae

Raidla, Peeter, 1955-

2008-01-01

Investor Rain Lõhmus ning ärimehed Elmut Paavel ja Raivo Hein räägivad oma põhimõtetest ja kogemustest ettevõtete müügist laekunud raha paigutamisel. Lisa: Valik viimaste aastate suurtehinguid. Vt. samas: Intervjuu Ambient Sound Investments tegevjuhi Tauno Tatsiga. Skype'i mehed jätkavad innovatiivselt

B nulevoi totshke Tallina vozdvigajetsja delovoje zdanije elitnogo klassa / Lauri Leet

Index Scriptorium Estoniae

Leet, Lauri

2008-01-01

Tallinnas 2007. a. sügisest käiva Metro Plaza ärihoone ehitust tutvustab projektijuht Kuldar Gil. Vastavalt muinsuskaitselistele nõudmistele säilitati vana hoone fassaadiosa. Hoone klaasfassaadi valguskujundusest. Ehitab Facio Ehituse AS. Arhitektuurne projekt: KOKO Arhitektid OÜ. Konstruktiivse osa projekteerija: Neoprojekt. Hoone kavandamist tutvustab arhitekt Raivo Kotov

Arvukad ranged keskkonnanõuded ahistavad keemiatööstuse ettevõtteid / Ketlin Priilinn

Index Scriptorium Estoniae

Priilinn, Ketlin, 1982-

2005-01-01

Ilmunud ka: Delovõje Vedomosti 24. aug. lk. 12. Eesti Keemiatööstuse Liidu tegevdirektor Hallar Maybaum, ES Sadolin AS-i juhatuse esimees Rein Reile ja OÜ Krimelte arendusdirektor Raivo Raba Euroopa Liidu kemikaalide direktiivi REACH mõjust Eesti keemiatööstuse ettevõtetele. Lisa: REACH piirab keemiafirmade tegevust

Metro Plaza za fasadom Rotermanna / Viktoria Jürmann

Index Scriptorium Estoniae

Jürmann, Viktoria

2008-01-01

Pandi nurgakivi Tallinnas Viru väljaku äärde rajatavale büroohoonele Metro Plaza. Säilitatakse vana fassaad, mille tõttu kujuneb hoone Viru väljaku ja Mere puiestee poolsel küljel kaetud galerii jalakäijatele. Projekteerisid Raivo Kotov ja Kaur Stöör

Terve maailma arhitektuurifestival / Urmas Oja

Index Scriptorium Estoniae

Oja, Urmas, 1981-2012

2008-01-01

Muljeid Barcelonas toimunud Maailma arhitektuurifestivalilt (World Architecture Festival) 22.-24. okt. 2008. a. Keskseks ürituseks oli rahvusvaheline arhitektuurikonkurss, esitati 722 tööd 63 riigist. Võidutöid kommenteerib Ene Läkk. Raivo Kotovi kommentaar "Eesti seekord ei osalenud". Küsimustele vastab arhitektuurifestivali programmidirektor Paul Finch. 17 fotot

Noored filmilinnas Rakveres / Sulev Teinemaa

Index Scriptorium Estoniae

Teinemaa, Sulev, 1947-

1999-01-01

Põhja- ja Baltimaade noorte videofilmifestival "Visions of Light" 2. okt.-ni Rakveres. Võisteldi vanusekategooriates 18-25 ja 7-17 aastased. Festivali parimad Roar Uthaug & Espen Egeland Norrast. Eestist said auhinna Kaspar Jancis, Katrin Kissa, Aleks Adamov. Videofilmide tegemise võimalustest Eestis. Raivo Kelomees rääkis võrguvideo lihtsamatest vormidest.

Numerical modelling of Charpy-V notch test by local approach to fracture. Application to an A508 steel in the ductile-brittle transition range; Modelisation de l'essai Charpy par l'approche locale de la rupture. Application au cas de l'acier 16MND5 dans le domaine de transition

Energy Technology Data Exchange (ETDEWEB)

Tanguy, B

2001-07-15

Ferritic steels present a transition of the rupture mode which goes progressively of a brittle rupture (cleavage) to a ductile rupture when the temperature increases. The following of the difference of the transition temperature of the PWR vessel steel by the establishment of toughness curves makes of the Charpy test an integrating part of the monitoring of the French PWR reactors. In spite of the advantages which are adapted to it in particular its cost, the Charpy test does not allow to obtain directly a variable which characterizes a crack propagation resistance as for instance the toughness used for qualifying the mechanical integrity of a structure. This work deals with the establishment of the through impact strength-toughness in the transition range of the vessel steel: 16MND5 from a non-empirical approach based on the local approach of the rupture. The brittle rupture is described by the Beremin model (1983), which allows to describe the dispersion inherent in this rupture mode. The description of the brittle fissure is carried out by the GTN model (1984) and by the Rousselier model (1986). This last model has been modified in order to obtain a realistic description of the brittle damage in the case of fast solicitations and of local heating. The method proposed to determine the parameters of the damage models depends only of tests on notched specimens and of the inclusion data of the material. The behaviour is described by an original formulation parametrized in temperature which allows to describe all the tests carried out in this study. Before using this methodology, an experimental study of the behaviour and of the rupture modes of the steel 16MND5 has been carried out. From the toughness tests carried out in quasi-static and dynamical conditions, it has been revealed that this steel does not present important unwedging of its toughness curve due to the velocity effect. In the transition range, local heating of about 150 C have been measured in the root

Võidupüha ja jaanipidu Melbourne'is / Raivo Rähni ; foto: Raivo Rähni

Index Scriptorium Estoniae

Rähni, Raivo, 1925-

2009-01-01

Melbourne'i Eesti Ühing "Kodu" poolt korraldatud peost Eesti Majas, kus sõna võtsid Bruno Metsar ja Diana Ritchie, esinesid Hilja Toom, Ambrose Ritchie, Mart ja Max Saarelaht, MEÜ "Kodu" Naiskoor, Angela Kerig jpt.

Why don't they accept non-invasive ventilation?: insight into the interpersonal perspectives of patients with motor neurone disease.

Science.gov (United States)

Ando, Hikari; Williams, Carl; Angus, Robert M; Thornton, Everard W; Chakrabarti, Biswajit; Cousins, Rosanna; Piggin, Lucy H; Young, Carolyn A

2015-05-01

Although non-invasive ventilation (NIV) can benefit survival and quality of life, it is rejected by a substantial proportion of people with motor neurone disease (MND). The aim of this study was to understand why some MND patients decline or withdraw from NIV. Nine patients with MND (male = 7, mean age = 67 years) participated in this study. These patients, from a cohort of 35 patients who were offered NIV treatment to support respiratory muscle weakness, did not participate in NIV treatment when it was clinically appropriate. Semi-structured interviews and interpretative phenomenological analysis (IPA) were employed to explore these patient's experience of MND and their thoughts and understanding of NIV treatment. Using IPA, four themes were identified: preservation of the self, negative perceptions of NIV, negative experience with health care services, and not needing NIV. Further analysis identified the fundamental issue to be the maintenance of perceived self, which was interpreted to consist of the sense of autonomy, dignity, and quality of life. The findings indicate psychological reasons for disengagement with NIV. The threat to the self, the sense of loss of control, and negative views of NIV resulting from anxiety were more important to these patients than prolonging life in its current form. These findings suggest the importance of understanding the psychological dimension involved in decision-making regarding uptake of NIV and a need for sensitive holistic evaluation if NIV is declined. Statement of contribution What is already known on this subject? Non-invasive ventilation is widely used as an effective symptomatic therapy in MND, yet about a third of patients decline the treatment. Psychological disturbance generated by NIV use leads to negative experiences of the treatment. Decision-making about treatment potentials is complex and unique to each individual affected by perceived impact of disease. What does this study add? A decision concerning

Ahp2 (Hop2) function in Arabidopsis thaliana (Ler) is required for stabilization of close alignment and synaptonemal complex formation except for the two short arms that contain nucleolus organizer regions.

Science.gov (United States)

Stronghill, P; Pathan, N; Ha, H; Supijono, E; Hasenkampf, C

2010-08-01

A cytological comparative analysis of male meiocytes was performed for Arabidopsis wild type and the ahp2 (hop2) mutant with emphasis on ahp2's largely uncharacterized prophase I. Leptotene progression appeared normal in ahp2 meiocytes; chromosomes exhibited regular axis formation and assumed a typical polarized nuclear organization. In contrast, 4',6'-diamidino-2-phenylindole-stained ahp2 pachytene chromosome spreads demonstrated a severe reduction in stabilized pairing. However, transmission electron microscopy (TEM) analysis of sections from meiocytes revealed that ahp2 chromosome axes underwent significant amounts of close alignment (44% of total axis). This apparent paradox strongly suggests that the Ahp2 protein is involved in the stabilization of homologous chromosome close alignment. Fluorescent in situ hybridization in combination with Zyp1 immunostaining revealed that ahp2 mutants undergo homologous synapsis of the nucleolus-organizer-region-bearing short arms of chromosomes 2 and 4, despite the otherwise "nucleus-wide" lack of stabilized pairing. The duration of ahp2 zygotene was significantly prolonged and is most likely due to difficulties in chromosome alignment stabilization and subsequent synaptonemal complex formation. Ahp2 and Mnd1 proteins have previously been shown, "in vitro," to form a heterodimer. Here we show, "in situ," that the Ahp2 and Mnd1 proteins are synchronous in their appearance and disappearance from meiotic chromosomes. Both the Ahp2 and Mnd1 proteins localize along the chromosomal axis. However, localization of the Ahp2 protein was entirely foci-based whereas Mnd1 protein exhibited an immunostaining pattern with some foci along the axis and a diffuse staining for the rest of the chromosome.

In silico analysis of β-mannanases and β-mannosidase from Aspergillus flavus and Trichoderma virens UKM1

Science.gov (United States)

Yee, Chai Sin; Murad, Abdul Munir Abdul; Bakar, Farah Diba Abu

2013-11-01

A gene encoding an endo-β-1,4-mannanase from Trichoderma virens UKM1 (manTV) and Aspergillus flavus UKM1 (manAF) was analysed with bioinformatic tools. In addition, A. flavus NRRL 3357 genome database was screened for a β-mannosidase gene and analysed (mndA-AF). These three genes were analysed to understand their gene properties. manTV and manAF both consists of 1,332-bp and 1,386-bp nucleotides encoding 443 and 461 amino acid residues, respectively. Both the endo-β-1,4-mannanases belong to the glycosyl hydrolase family 5 and contain a carbohydrate-binding module family 1 (CBM1). On the other hand, mndA-AF which is a 2,745-bp gene encodes a protein sequence of 914 amino acid residues. This β-mannosidase belongs to the glycosyl hydrolase family 2. Predicted molecular weight of manTV, manAF and mndA-AF are 47.74 kDa, 49.71 kDa and 103 kDa, respectively. All three predicted protein sequences possessed signal peptide sequence and are highly conserved among other fungal β-mannanases and β-mannosidases.

Diaphragm pacing and noninvasive respiratory management of amyotrophic lateral sclerosis/motor neuron disease.

Science.gov (United States)

Mahajan, Kedar R; Bach, John Robert; Saporito, Lou; Perez, Nick

2012-12-01

Although it is known that continuous noninvasive ventilation (CNIV) can prolong life in amyotrophic lateral sclerosis/motor neuron disease (ALS/MND), in this study we explore similar claims for diaphragm pacing (DP). NIV and DP users' vital capacities (VCs) over time and duration of NIV and CNIV dependence were analyzed for 354 non-DP and 8 DP ALS/MND patients. Patients had a higher rate of monthly VC decline before NIV use (5.1 ± 7.6%) than during NIV use (2.5 ± 3.6%) (P NIV for 19.9 ± 27.6 months until tracheostomy/death, whereas 113 others used it for 10.9 ± 10.5 months until CNIV dependence for another 12.8 ± 16.2 months. After placement, 7 DP users were CNIV dependent in 8.0 ± 7.0 months, whereas 6 underwent tracheostomy/died in 18.2 ± 13.7 months. CNIV prolonged the survival of 113 of the 354 non-DP and 6 DP ALS/MND patients by 12.8 and 10.2 months, respectively. DP provided no benefit on VC or mechanical ventilation-free survival. Copyright © 2012 Wiley Periodicals, Inc.

Experience of long-term use of non-invasive ventilation in motor neuron disease: an interpretative phenomenological analysis.

Science.gov (United States)

Ando, Hikari; Chakrabarti, Biswajit; Angus, Robert M; Cousins, Rosanna; Thornton, Everard W; Young, Carolyn A

2014-03-01

Although non-invasive ventilation (NIV) can promote quality of life in motor neuron disease (MND), previous studies have disregarded the impact of progression of illness. This study explored how patients' perceptions of NIV treatment evolve over time and how this was reflected in their adherence to NIV. Five patients with MND (male=4, mean age=59 years), from a bigger cohort who were prospectively followed, had multiple post-NIV semistructured interviews, covering more than 12 months, along with ventilator interaction data. The transcribed phenomenological data were analysed using qualitative methodology. Three themes emerged: experience of NIV, influence on attitudes and perceived impact of NIV on prognosis. The ventilator interaction data identified regular use of NIV by four participants who each gave positive account of their experience of NIV treatment, and irregular use by one participant who at interview revealed a negative attitude to NIV treatment and in whom MND induced feelings of hopelessness. This exploratory study suggests that a positive coping style, adaptation and hope are key factors for psychological well-being and better adherence to NIV. More studies are needed to determine these relationships.

Dzhässikavad toovad linna jõulurõõmu / Silja Joon

Index Scriptorium Estoniae

Joon, Silja, 1966-

2008-01-01

"Jazzkaare" kolm dzhässiõhtut Pärnus - 3. dets. Eliisabeti kirikus Raivo Tafenau, Ain Agan ja Laura Põldvere, 9. dets. Endla teatris Saksamaa vokaalansambel Berlin Voices (Esther Kaiser, Sarah Kaiser, Marc Secara, Kristofer Benn) ja 11. dets. Ammende villas norra laulja Gine Andressen. Berlin Voices soojendusansamblina esineb Pärnu noorte vokaalansambel Greip

Pidu "Pehmete ja karvaste" pesas / Kairit Tsäro

Index Scriptorium Estoniae

Tsäro, Kairit, 1974-

2002-01-01

ETV poliitilise pila nukushõu "Pehmed ja karvased" : stsenaristid Toomas Kall ja Andrus Kivirähk : idee autor, režissöör ja kunstnik Hardi Volmer : produtsent, idee autor Raivo Suviste. Muljeid ühest võttepäevast. Ka osatäitjate nimekiri. Ka : Teleleht nr. 10, lk. 12-13

Tartu Ülikooli Narva Kolledž = University of Tartu Narva College / Hannes Praks

Index Scriptorium Estoniae

Praks, Hannes, 1973-

2013-01-01

Eesti Sisearhitektide Liidu 2012. aasta parima avaliku ruumi preemia pälvinud TÜ Narva Kolledzi sisekujundusest. Autorid: Hannes Praks, Kadri Tamme, Kristjan Holm, Liisi Murula, Toomas Pääsuke, Ahti Grüngerg, Daniel Marius Reisser, Helen Sarapuu. Arhitektuur: Kavakava. ESLi aastapreemiate žürii liikmete Raivo Puusepa ja Mari Kurismaa arvamused

Ähvardus : olümpiamängude teleülekanne jääb ära / Kai Kalamees

Index Scriptorium Estoniae

Kalamees, Kai

2005-01-01

Riigikogu liige Jaak Allik peab vajalikuks leida ETV-le lisamiljoneid olümpiamängude ja jalgpalli MM-i teleülekanneteks. Riigikogu liikmed Olav Aarna ja Katrin Saks kritiseerisid valitsust, et rahvusringhäälingu arengukava suhtes pole võetud seisukohta. Kultuuriminister Raivo Palmaru arvamusi. Lisa: Ringhäälingureform tulekul

Tallinna Visioonikonverents 2010 : Linn ja linnakultuur 22. sajandil

Index Scriptorium Estoniae

2010-01-01

Tallinna Lauluväljaku ruumides 22. novembril toimunud Tallinna Visioonikonverentsist "Linn ja linnakultuur 22. sajandil", kus arutleti teemal, milline võiks olla Tallinn saja aasta pärast. Konverentsil esinesid Toomas Vitsut, Mart Saarma, Jan Sturesson, Raivo Raave, Satish Kumar, Juhani Pallasmaa ning moderaatoriteks olid Hardo Aasmäe ja Mati Heidmets

Study on antioxidant experiment on forged steel tube sheet and tube hole for steam generator

International Nuclear Information System (INIS)

Zong Hai; Wang Detai; Ding Yang

2012-01-01

Antioxidant experiment on forged steel tube sheet and tube hole for steam generator was studied and the influence of different simulated heat treatments on the antioxidant performance of tube sheet and tube hole was made. The influence of different antioxidant methods on the size of tube hole was drawn. Furthermore, the change of size and weight of 18MnD5 forged steel tube sheet on the condition of different simulated heat treatments was also studied. The analytical results have proved reference information for the use of 18MnD5 material and for key processes of processing tube hole and wearing and expanding U-style tube. (authors)

Millest nad kirjutavad ehk Näidendivõistluse tänavusügisene saak / Triin Sinissaar

Index Scriptorium Estoniae

Sinissaar, Triin

2003-01-01

I preemia: Urmas Lennuk, "Boob teab"ja Jaan Undusk, "Quevedo"; II preemia: Anu Allas, "Lendav rõdu ehk Nagu nad tahtsid" ja Raivo Kütt, "Papa" ("Sõtse ja venna"); III preemia Jakob Karu, "Asjade seis" ja Hans Nordberg, "aaron : juuni"; ergutuspreemia: Urmas Lennuk, "Kadunud kindapood", Urmas Vadi, "Kadunud kosmoses" ja Jaan Võõramaa, "Mamma"

KOKO Arhitektide bürooruumid = Offices of KOKO architects

Index Scriptorium Estoniae

2008-01-01

KOKO Arhitektide bürooruumide (Fahle majas Tartu mnt. 84A, Tallinn) sisekujundus. Sisekujunduse autorid: Raivo Kotov, Andrus Kõresaar, Liis Lindvere, Raili Paling. Mustrid büroo klaasseintel ja põrandatel: Martin Lazarev. Sisekujundajatest, nende tähtsamad tööd. III-VI korruse ja antresoolkorruse plaan, 8 värv. vaadet, fotod sisekujundajatest

Metro Plaza tõi Viru väljakule LED-valguse hõõguva tuledemängu / Maris Meiessaar

Index Scriptorium Estoniae

Meiessaar, Maris

2009-01-01

2009. a. alguses Tallinnas Viru väljak 2 valmivast ärihoonest ja selle klaasfassaadide valgustusest. Ärihoone seisab 19. saj. ehitatud maja muinsuskaitse all oleva fassaadi taga. Autorid: büroo KOKO Arhitektid arhitektid Raivo Kotov ja Lembit-Kaur Stöör ning sisearhitektid Liis Lindvere ja Raili Paling. Ehitaja: Facio Ehitus

Selgusid näidendivõistluse võitjad

Index Scriptorium Estoniae

2003-01-01

I preemia: Urmas Lennuk "Boob teab"ja Jaan Undusk "Quevedo"; II preemia: Anu Allas "Lendav rõdu ehk Nagu nad tahtsid" ja Raivo Kütt "Papa (Sõtse ja venna)"; III preemia Jakob Karu "Asjade seis" ja Hans Nordberg "aaron : juuni"; ergutuspreemia: Urmas Lennuk "Kadunud kindapood", Urmas Vadi "Kadunud kosmoses" ja Jaan Võõramaa "Mamma"

Euroopat tutvustav film räägib ka Virumaast / Eva Klaas

Index Scriptorium Estoniae

Klaas, Eva, 1977-

2009-01-01

Belgia telemehed Robin Shuffield ja Malick Jeddi ning Eesti helioperaator Antti Mass filmisid Virumaal klippi filmi "20 aastat hiljem" jaoks, kus Rein SIkk ja Raivo Riim meenutasid 1988. ja 1989. aasta sündmusi Eestis. Film räägib demokraatia muutustest nn uutes Euroopa maades pärast Berliini müüri langemist

Saagu valgus / Karin Tarto

Index Scriptorium Estoniae

Paulus, Karin, 1975-

1998-01-01

Eesti valgustikujundajatest ja valgustitest. Kas eesti disaineritel on õnnestunud leida oma nišš lambiletil. Tootjatest : OÜ "Raunto", AS "Titanus" (disaineriks Eestis elav rootslane Renni Par)-, Norrast pärineva kontserni "Glamox" tehasest Keilas, "Estoplastist" (disainerid Martin Pärn, Raido Laasing), AS "Steel Line". Valgustikujundajatest Tarmo Luisust, Aleksander Jakovlevist, Raivo Pristolist, Mait Summatavetist, Tõnis Vellamast

Vaiklate ühine käejoon / Piret Veigel-Sepman

Index Scriptorium Estoniae

Veigel-Sepman, Piret

1999-01-01

Eesti sisearhitektidest Tüüne-Kristin ja Urmo Vaiklast. 1992. a. lõid Vaikla Stuudio, mis tegutseb interjööridisaini ja graafilise disaini alal. Viimasest suurest tööst: Raivo Puusepa projekteeritud Al Mare tervise- ja vaba aja keskuses asuva tervisespordiklubi Status Clubi sisekujundusest. Kujunduse läbiv idee on laev. 4 illustratsiooni

Väike-suur punane maja männimetsa all : elamu Laulasmaal = The Little Big Red House in the Pine Forest : Dwelling in Laulasmaa / Üla Koppel

Index Scriptorium Estoniae

Koppel, Üla

2003-01-01

Puitkarkassiga suvilaks ehitatud maja on väljast kaetud veekindla vineeriga. Vineeri on osaliselt kasutatud ka siseviimistluses. Projekteerija: KOKO Arhitektid / Kõresaar & Kotov OÜ. Autorid Raivo Kotov, Andrus Kõresaar. Konstruktor: Inseneribüroo Peipman OÜ. Sisearhitekt Hannes Praks. Projekt 2001, valmis 2003. 3 välis- ja 2 sisevaadet, I ja II korruse plaan, lõige

Eesti arhitektuuriuudised / Aale Kask

Index Scriptorium Estoniae

Kask, Aale

2007-01-01

"Eesti betoonehitis 2006" preemia saanud Hindrek Kesleri projekteeritud Luku-Experdi maja Tartu maanteel (Büroo AB Zero), Aasa külalistemajaks Raivo Mändmaa poolt renoveeritud vana maja Viljandis, skulptor Jass Kaselaane kavandite järgi valminud maasikad Viljandi linnas, mis tähistavad teed Paul Kondase keskusesse, põhumaja Nina külas

Developing Earth and Space Scientists for the Future

Science.gov (United States)

Manduca, Cathryn A.; Cifuentes, Inés

2007-09-01

As the world's largest organization of Earth and space scientists, AGU safeguards the future of pioneering research by ensuring that ``the number and diversity of Earth and space scientists continue to grow through the flow of young talent into the field'' (AGU Strategic Plan 2008, Goal IV). Achieving this goal is the focus of the AGU Committee on Education and Human Resources (CEHR), one of the Union's three outreach committees.

Panel drafts position on U.S. science budget

Science.gov (United States)

The AGU panel charged with writing the Union position on the U.S. fiscal 1993 budget met at AGU Headquarters on February 27 to draft their statement and hear from representatives of federal science agencies. The panel's position statement is expected to be completed by the end of March, pending approval by the AGU Council.AGU has drafted positions on the U.S. science budget since 1990. This year's panel includes Terry E. Tullis (chair), Brown University; H. Frank Eden, General Electric Astro Space; Thomas E. Pyle, Joint Oceanographic Institutions, Inc.; Thomas Potemra, Johns Hopkins Applied Physics Laboratory; David W. Simpson, Incorporated Research Institutions for Seismology; Steven W. Squyres, Cornell University; and Eric F. Wood, Princeton University.

Infoühiskond / Raivo Suni

Index Scriptorium Estoniae

Suni, Raivo, 1976-

1999-01-01

Infoühiskond on paradigmana sattunud sotsiaalteadlaste tähelepanu alla seoses informatsiooni plahvatusliku väärtustumisega viimastele aastatel. Ka kultuuriimperialismist, kulturoloogilisest lähenemisest. Meediatehnoloogia areng on aidanud levida väärtustel, mis varem olid kättesaadavad vaid eliidile (Walter Benjamin "The Work of Art in the Age of Mechanical Reproduction")

Patud investori aktsiaportfellis / Raivo Sormunen

Index Scriptorium Estoniae

Sormunen, Raivo, 1976-

2005-01-01

Patuaktsiateks (sinful stocks) nimetatakse nende ettevõtete väärtpabereid, mille tegevuses leidub ebaeetilisi või moraalivastaseid külgi. Tabel: Maailma suurimad ebaeetilised ja moraalivastased ettevõtted

Kas teha konteinerklass? / Raivo Juurak

Index Scriptorium Estoniae

Juurak, Raivo, 1949-

2011-01-01

Koolikorraldusest ja koolidesse vastuvõtust Soomes, Saksamaal ja Inglismaal. Arvamusi avaldavad Soomes õpetajana töötavad Tiiu Jürisson ja Arvi Nikkarev, pikaajalise Soomes töötamise kogemusega TLÜ lektor Anu Carlsson ning Saksamaal Hessenis õpetajana töötav Kadri Heller

Innovatsioonipoliitika kavandamisest Eestis / Raivo Linnas

Index Scriptorium Estoniae

Linnas, Raivo

2007-01-01

Artiklis nenditakse, et innovatsioonipoliitika on lahustunud erinevate strateegiate vahel ning riik on loobunud oma juhtivast rollist, eduka poliitika elluviimine sõltub aga riigi tahtest arendada teadmistepõhist majandust, koostööst, tippteadlaste suurest arvust, teadus- ja arendustegevusele soodsate tingimuste loomisest

"Ars Electronica 2009" / Raivo Kelomees

Index Scriptorium Estoniae

Kelomees, Raivo, 1960-

2009-01-01

30. "Ars Electronica" festival "Human Nature" ("Inimese loomus") Linzis. Osaka ülikooli professori Hiroshi Ishiguro mehaanilis-digitaalsest nukust. Hübriidkunsti kategoorias peapreemia saanud Eduardo Kaci inimtaimest. Konverentsidest. Näitusest "See this Sound", mis oli pühendatud helile kujutavas kunstis

Elukestev õpe Euroopas / Raivo Juurak

Index Scriptorium Estoniae

Juurak, Raivo

2007-01-01

Tallinna Ülikooli andragoogide ja sotsioloogidega kohtus täiskasvanuhariduse teoreetik ja filosoof professor Peter Jarvis. Peter Jarvis külastas Eestit kuna, TLÜ Rahvusvaheliste ja Sotsiaaluuringute Instituut koordineerib 13 riiki hõlmavat projekti "Towards Life-long Learning Society in Europe : the Contribution of Educational System" ("Haridussüsteemi roll elukestval õppel põhineva ühiskonna rajamisel"), lühidalt LLL2010. LLL2010 on Euroopa Liidu 6. raamprogrammi integreeritud projekt, millega tahetakse saada ülevaadet täiskasvanuharidusest Euroopas

Hüperaktiivne laps / Raivo Juurak

Index Scriptorium Estoniae

Juurak, Raivo, 1949-

2001-01-01

12. mail 2001 arutasid lastepsühhiaatrid ja kooliõpetajad Tallinnas seminaril hüperaktiivsete ja tähelepanupuudulikkusega laste probleemi. Ettekanded pidasid lastepsühhiaatria dotsent Seija Sandberg Helsingi ülikoolist ja lastepsühhiaater Raija Hirsch Stockholmist

Kunst eluetenduste inspireerijana / Raivo Kelomees

Index Scriptorium Estoniae

Kelomees, Raivo, 1960-

2005-01-01

Kunstnikuetenduste põhilised tundemärgid. Inglise kirjaniku John Fowlesi novellist "Eebenipuust torn" ja selle põhjal tehtud lavastusest. Novellile sarnaselt käitusid Valdur Ohakas ja tema kaks kaaslast 1980. aastate alguses Kütioru talus

Mida ootab lapsevanem? / Raivo Juurak

Index Scriptorium Estoniae

Juurak, Raivo, 1949-

2009-01-01

Eesti koostöö kogu programmijuht Mati Salundi ja Tallinna Ülikooli sotsiaaltöö instituudi dotsent Anne Tiko viisid möödunud kevadel läbi uuringu, kus selgitasid, mida ootavad 1. klassi astuvate laste vanemad lasteaialt, koolilt, õpetajalt, kohalikult omavalitsuselt. Uuringu tulemusi kommenteerisid vestlusringis Mati Salundi, Lastevanemate Liidu koolitusjuht Kristiine Vahtramäe ja uuringu retsensent, Tallinna Ülikooli kasvatusteaduse instituudi professor Marika Veisson

Eesti videokunsti otsingutel / Raivo Kelomees

Index Scriptorium Estoniae

Kelomees, Raivo, 1960-

2006-01-01

XII Pärnu rahvusvaheline video- ja filmifestival "Klassiahastus" Pärnu mudaravilas 18. ja 19. XI. Peapreemia sai Kristina Normanni video "Pribaldid", ära märgiti Moira Tierney video "Yoyoyogasmana". Inglismaal Brightonis 1.-3. XII toimuva festivali kava

Programmeerimine kui keeleoskus / Raivo Hool

Index Scriptorium Estoniae

Hool, Raivo

2015-01-01

Tutvustus: Carol Vorderman. Õpime üheskoos programmeerima : visuaalne teejuht algajale kahendkoodist kuni mängude koostamiseni; Õpime üheskoos matemaatikat : visuaalne teejuht arvutamisest statistikani. Tallinn, 2015

Elukestva õppe strateegia / Raivo Juurak

Index Scriptorium Estoniae

Juurak, Raivo

2001-01-01

Haridusministeeriumi eestvõttel on alustatud diskussioone Eestile elukestva õppe strateegia koostamiseks. Moodustatud komisjonis on juhtiv koht on koolitusfirmade assotsiatsiooni Andras juhatuse esimehel prof. T. Märjal ja prof. Ü. Vooglaiul. Komisjoni koosseisu kuuluvad veel: Eesti Vabaharidusliidu juhatuse esimees I. Eesmaa, Kõrgema Kommertskooli õppetoolijuhataja T. Elenurm, TPÜ akadeemiline prorektor L. Jõgi, Mainori Majanduskooli rektor P. Kross, haridusministeeriumi täiskasvanuhariduse talituse juhataja T. Ots, koolitusfirma Invicta juhatuse esimees M. Pärjamäe, Rocca al Mare Kooli juhataja H. Tamjärv, Viljandi Kultuurikolledži prof. R. Valgma jt.

"Tehnobia" - taaskohtumine tulevikuga / Raivo Kelomees

Index Scriptorium Estoniae

Kelomees, Raivo, 1960-

2006-01-01

Leonhard Lapini kureeritud Eesti Kunstnike Liidu aastanäitus "Tehnobia" Tallinna Kunstihoones. Näituse avamisel nägi rahvusvahelise performance'i-festivali "Diverse Universe II" (korraldajad Al Paldrok, Mari Kartau) performance'eid

Supporting wellbeing in motor neurone disease for patients, carers, social networks, and health professionals: A scoping review and synthesis.

Science.gov (United States)

Harris, Melanie; Thomas, Geoff; Thomas, Mary; Cafarella, Paul; Stocks, Allegra; Greig, Julia; McEvoy, R Doug

2018-04-01

ABSTRACTObjective:Disease management in motor neurone disease (MND) is focused on preserving quality of life. However, the emphasis has so far been on physical symptoms and functioning and not psychosocial wellbeing. MND affects the wellbeing of carers, of family and social network members, and of healthcare providers, as well as of the patients. We therefore aimed to assess and synthesize the knowledge about maximizing MND-related psychosocial wellbeing across all these groups. We used a systematic search and selection process to assess the scope of the literature along with a narrative synthesis of recent high-quality reviews. The original studies were mainly observational studies of patients and, to a lesser extent, of carers. There were few interventional studies, mainly of patients. There were very few studies of any type on wellbeing in their wider social network or in healthcare professionals. All the review literature looked at MND patient or carer wellbeing, with some covering both. No reviews were found of wellbeing in other family members, patients' social networks, or their healthcare professionals. The reviews demonstrated wellbeing problems for patients linked to psychosocial issues. Carer wellbeing is also compromised. Psychotherapies, social supports, improved decision supports, and changes to healthcare delivery are among the suggested strategies for improved patient and carer wellbeing, but no proven interventions were identified for either. Early access to palliative care, also not well-tested but recommended, is poorly implemented. Work on interventions to deal with well-established wellbeing problems for patients and carers is now a research priority. Explicit use of current methods for patient and public involvement and for design and testing of interventions provide a toolkit for this research. Observational research is needed in other groups. There is a potential in considering needs across patients' social networks rather than looking

Identifying who will benefit from non-invasive ventilation in amyotrophic lateral sclerosis/motor neurone disease in a clinical cohort.

Science.gov (United States)

Berlowitz, David J; Howard, Mark E; Fiore, Julio F; Vander Hoorn, Stephen; O'Donoghue, Fergal J; Westlake, Justine; Smith, Anna; Beer, Fiona; Mathers, Susan; Talman, Paul

2016-03-01

Respiratory failure is associated with significant morbidity and is the predominant cause of death in motor neurone disease/amyotrophic lateral sclerosis (MND/ALS). This study aimed to determine the effect of non-invasive ventilatory (NIV) support on survival and pulmonary function decline across MND/ALS phenotypes. Cohort recruited via a specialist, multidisciplinary clinic. Patients were categorised into four clinical phenotypes (ALS, flail arm, flail leg and primary lateral sclerosis) according to site of presenting symptom and the pattern of upper versus lower motor neurone involvement. NIV was initiated according to current consensus practice guidelines. Between 1991 and 2011, 1198 patients diagnosed with ALS/MND were registered. 929 patients (77.5%) fulfilled the selection criteria and their data were analysed. Median tracheostomy free survival from symptom onset was 28 months in NIV-treated patients compared to 15 months in untreated (Univariate Cox regression HR=0.61 (0.51 to 0.73), pNIV persisted when the model was adjusted for age, gender, riluzole and percutaneous endoscopic gastrostomy use (HR=0.72 (0.60 to 0.88, p=0.001). In contrast with the only randomised controlled trial, NIV statistically significantly increased survival by 19 months in those with ALS-bulbar onset (Univariate HR=0.50 (0.36 to 0.70), multivariate HR=0.59 (0.41 to 0.83)). These data confirm that NIV improves survival in MND/ALS. The overall magnitude of benefit is 13 months and was largest in those with ALS-bulbar disease. Future research should explore the optimal timing of NIV initiation within phenotypes in order to optimise respiratory function, quality of life and survival. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Amatöörid pidasid 40. festivali / Tõnu Aru

Index Scriptorium Estoniae

Aru, Tõnu

2005-01-01

8.-23. aprillini toimunud 40. Eesti amatöörfilmide festivalil auhinna saanud filmidest. Peaauhinna võitis Kullar Viimse tõsielufilm "Jumalaga", esimese koha sai üliõpilase Asko Kase mängufilm "Kooma", II koha sai Raivo Mangluse loodusfilm "Metsataguseid meenutusi", III koha Tõnu Aru tõsielufilm "Õletuust ja okastraat". Toimus ka animafilmikonkurss "Keisri uued rõivad"

Rotermanni laudsepatöökoda rändab näitusele / Mari Kodres

Index Scriptorium Estoniae

Kodres, Mari

2009-01-01

2009. aasta Euroopa Liidu nüüdisaegse arhitektuuri preemia ehk Mies van der Rohe auhinna sai Norra arhitektuuribüroo Snohetta Oslo ooperi- ja balletiteatri eest. Üleeuroopalisele rändnäitusele ja kataloogi valiti Eestisse rajatud hoone - KOKO Arhitektide Andrus Kõresaare ja Raivo Kotovi laudsepatöökoja rekonstruktsioon Rotermanni kvartalis Tallinnas. Teistest nominentidest Eestist

Investor, mine rahaga Venemaale ja Poola / Liis Kängsepp

Index Scriptorium Estoniae

Kängsepp, Liis, 1981-

2008-01-01

Analüütikud soovitavad investeerida Venemaa, Poola, Brasiilia või USA aktsiaturgudele, Balti riikide suhtes ollakse aga umbusklikud. Vt. samas: Kas nüüd lõpuks on põhi käes? Raivo Sormunen. Aktsiaturu languse põhjused; Aktsiate ostmise A&O; Diagramm: Börside langus. Kommenteerivad Meelis Atonen, Märt Luuk, Arvo Nõges ja Jaan Talts

Tartu noored kunstnikud salapärasuse vaimustuses / Margus Kiis

Index Scriptorium Estoniae

Kiis, Margus

2003-01-01

Tartu Noorte Kunstnike Näitusest Tartu Kunstnike Majas. Iseloomustatud Priit Pajose, Lauri Pajose, Margus Pumpa, Andres Sütevaka, Kaie Luige, Maris Palgi, Külli Suitso, Kadri Kängsepa, Peeter Krossmani, Saimi Kalevi Makkoneni, Kaarel Vulla, Katri Kuuski, Väike Tomi, Meiu Mündi, Karol Kagovere, Meta Narusbeli, Aili Penti, Kene Triive ja Raivo Irdi töid

offline@online / Rael Artel

Index Scriptorium Estoniae

Artel, Rael, 1980-

1999-01-01

Raivo Kelomehe kureeritud offline@online meediakunsti festival alapealkirjaga "Media non grata" EKA küberkohvikus "Enter". Peamiselt Eesti ekspositsioonist. CD-ROMe esitlesid: R. Kelomees, M. Mäetamm, R. Keller, K. Sibul, I. Kivi, T. Lepik. M. Lillaku, J. Orgussaare, R. Kelleri, Pusa ja J. Bergi filmidest. Moskva Kaasaegse Kunsti Keskuse MediaArtLabi, M. Holboomi, G. Mülleri esinemisest

Nukufilmi erootika / Jaan Ruus

Index Scriptorium Estoniae

Ruus, Jaan, 1938-2017

2005-01-01

Kaks eesti nukufilmi - "Laud" : autorid Jelena Girlin ning Mari-Liis Bassovskaja : operaator ja kaasrežissöör Urmas Jõemees : helilooja Malle Maltis : Nukufilm OÜ 2004 ja "Generatio" : stsenarist, kunstnik ja režissöör Mait Laas : konsultant Paavo Matsin : operaatorid Ragnar Neljandi, Raivo Möllits : helilooja Tiit Kikas : Nukufilm OÜ - Icon Film (Saksamaa) 2005

Kuressaare kursiivis on Arensburg / Urmas Oja

Index Scriptorium Estoniae

Oja, Urmas, 1981-2012

2007-01-01

Arensburg Boutique Hotel & Spa lisahoone Kuressaares Lossi t. 15. Arhitektid: Raivo Kotov, Margit Kärner ja Lea Laidra, KOKO Arhitektid OÜ. Sisekujundus: Liisi Murula Maridisain OÜ-st ja Raili Paling KOKO Arhitektid OÜ-st. Ehitustööde peatöövõtja: AS EBC Ehitus. Ehitusaeg: 2005-2007. 7 värv. välisvaadet

Arhitektuuriaasta 2006 = The year in architecture 2006 / Liina Jänes

Index Scriptorium Estoniae

Jänes, Liina, 1977-

2007-01-01

Eesti Kultuurkapitali aastapreemia 2006 saanutest. Peaauhinna sai Raine Karp, restaureerimispreemia Mart Kalm ja Ado Talimaa (O. Siinmaa villa ja mööbli restaureerimine), parima arhitektuurse objekti preemia Andrus Kõresaar ja Raivo Kotov (Fahle maja), sisekujunduspreemia Tarmo Piirmets (Skype'i büroo), arhitektuurialase uurimuse preemia Mart Siilivask ("Tartu arhitektuur 1830-1918"), disainipreemia Eesti Disainerite Liit

Tallinki esimene börsipäev pettis väikeinvestorite ootusi / Hindrek Riikoja

Index Scriptorium Estoniae

Riikoja, Hindrek

2005-01-01

Tallinki aktsia esimene börsipäev valmistas paljudele väikeinvestoritele pettumust, kuna aktsia hind tõusis päevaga vaid 58 senti ehk 0,7 protsenti. Lisa: Kas teate? Küsimusele, mida teete Tallinki aktsiatega, vastavad: ettevõtja Indrek Toome, Riigikogu liige Margus Hanson, teleprodutsent Raivo Suviste ja AS-i Biodiesel nõukogu esimees Heino Harak

EMG analysis in 78 cases with motor neuron disease

Institute of Scientific and Technical Information of China (English)

Zhang Qiubin

2000-01-01

This paper analysed the FMGs of 78 cases with the motor neuron disease(MND). The EMG of all patients showed following characteristics that the average duration of wave prolonged, the average voltage increased and it was found that fibrillation and fasciculatton potentials appeared spontaneously. The fibrillation potential of ENG waa related to course of disease. In the patients whose course of disease was short, the fibri llation potential increased obviously, while in the cases of chronic MND, It usually decreased. The motor nerve conduction velocity of most pa tients (41%) reduced, however, the sensory nerve conduction velocity was normal but two. We reviewed some references about EMG of the motor neuron disease and discussed their characteristics and mechanism

Raivo Tafenau: olen võetud väärikasse seltskonda / Raivo Tafenau ; intervjueerinud Tiiu Laks

Index Scriptorium Estoniae

Tafenau, Raivo, 1963-

2010-01-01

Vestlus Jazzkaare raames 28. aprillil toimunud Eesti džässiauhindade väljaandmisel Eesti džässiauhinna pälvinud saksofonistiga. Noore džässitalendi auhind anti Peedu Kassile, džässiedendaja auhind Boris Paršinile

New management structure at headquarters

Science.gov (United States)

On July 1, 1987, AGU Executive Director Fred Spilhaus informed the AGU staff that Judy C. Holoviak has been promoted to the position of Group Director. This is a new management position with responsibility for more than one division. Both the Publications Division and the newly formed Public Information and Marketing Division will report to Holoviak, as will the new Special Assistant for Nonprint Publications.Spilhaus explained that this new position will permit the headquarters management staff to be responsive to the current AGU growth. A stronger management structure is needed to take advantage of the many opportunities facing the Union. In pointing to the initiatives identified by the Planning Committee, he stated that continued growth is the only likely course for AGU.

Differential regional cerebral glucose metabolism in clinical syndromes of frontotemporal lobar degeneration: a study with FDG PET

International Nuclear Information System (INIS)

Park, J. M.; Cho, S. S.; Na, D. L.; Lee, K. H.; Choi, Y.; Choe, Y. S.; Kim, B. T.; Kim, S. E.

2001-01-01

Frontotemporal lobar degeneration( FTLD) is the third most common dementia, following Alzheimer's disease and Lewy body disease. Four prototypic neurobehavioral syndromes can be produced by FTLD: frontotemporal dementia (FTD), frontotemporal dementia with motor neuron disease (MND), semantic dementia (SD), and progressive aphasia (PA). We investigated patterns of metabolic impairment in patient with FTLD presented with four different clinical syndromes. We analysed glucose metabolic patterns on FDG PET images obtained from 34 patients with a clinical diagnosis of FTLD (19 FTD, 6 MND, 6 SD, and 3 PA, according to a consensus criteria for clinical syndromes associated with FTLD) and 7 age-matched healthy controls using SPM99. Patients with FTD had metabolic deficit in the left frontal cortex and bilateral anterior temporal cortex. Hypometabolism in the bilateral premotor are was shown in patients with MND. Patients with SD had metabolic deficit in the left posterior temporal cortex including Wernicke's area, while hypometabolism in the bilateral inferior frontal gyrus including Broca's area and left angular gyrus was seen in patients with PA. These metabolic patterns were well correlated with clinical features of FTLD syndromes. These data provide a biochemical basis of clinical classification of FTLD. FDG PET may help evaluate and classify patients with FTLD

Regional cerebral glucose metabolism in frontotemporal lobar degeneration

International Nuclear Information System (INIS)

Park, J.M.; Cho, S.S.; Lee, K.-H.; Choi, Y.; Choe, Y.S.; Kim, B.-T.; Kim, S.E.; Kwon, J.C.; Na, D.L.

2002-01-01

Purpose: Frontotemporal lobar degeneration (FTLD) is the third most common cause of dementia, following Alzheimer's disease and Lewy body disease. Four prototypic neuro behavioral syndromes can be produced by FTLD: frontotemporal dementia (FTD), frontotemporal dementia with motor neuron disease (MND), semantic dementia (SD), and progressive aphasia (PA). We investigated patterns of metabolic impairment in patients with FTLD presented with four different clinical syndromes. Methods: We analyzed glucose metabolic patterns on FDG PET images obtained from 34 patients with a clinical diagnosis of FTLD (19 FTD, 6 MND, 6 SD, and 3 PA, according to a consensus criteria for clinical syndromes associated with FTLD) and 7 age-matched healthy controls using SPM99. Results: Patients with FTD had metabolic deficit in the left frontal cortex and bilateral anterior temporal cortex. Hypometabolism in the bilateral pre-motor area was shown in patients with MND. Patients with SD had metabolic deficit in the left posterior temporal cortex including Wernicke's area, while hypometabolism in the bilateral inferior frontal gyrus including Broca's area and left angular gyrus was seen in patients with PA. These metabolic patterns were well correlated with clinical and neuropsychological features of FTLD syndromes. Conclusion: These data provide a biochemical basis of clinical classification of FTLD. FDG PET may help evaluate and classify patients with FTLD

Differential regional cerebral glucose metabolism in clinical syndromes of frontotemporal lobar degeneration: a study with FDG PET

Energy Technology Data Exchange (ETDEWEB)

Park, J. M.; Cho, S. S.; Na, D. L.; Lee, K. H.; Choi, Y.; Choe, Y. S.; Kim, B. T.; Kim, S. E. [College of Medicine, Sungkyunkwan Univ., Seoul (Korea, Republic of)

2001-07-01

Frontotemporal lobar degeneration( FTLD) is the third most common dementia, following Alzheimer's disease and Lewy body disease. Four prototypic neurobehavioral syndromes can be produced by FTLD: frontotemporal dementia (FTD), frontotemporal dementia with motor neuron disease (MND), semantic dementia (SD), and progressive aphasia (PA). We investigated patterns of metabolic impairment in patient with FTLD presented with four different clinical syndromes. We analysed glucose metabolic patterns on FDG PET images obtained from 34 patients with a clinical diagnosis of FTLD (19 FTD, 6 MND, 6 SD, and 3 PA, according to a consensus criteria for clinical syndromes associated with FTLD) and 7 age-matched healthy controls using SPM99. Patients with FTD had metabolic deficit in the left frontal cortex and bilateral anterior temporal cortex. Hypometabolism in the bilateral premotor are was shown in patients with MND. Patients with SD had metabolic deficit in the left posterior temporal cortex including Wernicke's area, while hypometabolism in the bilateral inferior frontal gyrus including Broca's area and left angular gyrus was seen in patients with PA. These metabolic patterns were well correlated with clinical features of FTLD syndromes. These data provide a biochemical basis of clinical classification of FTLD. FDG PET may help evaluate and classify patients with FTLD.

Decentralised CHP in a competitive market

DEFF Research Database (Denmark)

Lund, Henrik

2004-01-01

The article agues that decentralised CHP plants is an important part of energy supply in Denmark.......The article agues that decentralised CHP plants is an important part of energy supply in Denmark....

Loss muinasjuturaamatust / Agu Veetamm

Index Scriptorium Estoniae

Veetamm, Agu, 1953-

2004-01-01

Ballindaloch on üks väheseid Shoti losse, kus omanikud aastaringselt elavad. 450 aastat on loss kuulunud Macpherson-Grantide suguvõsale. Praegu on lossi omanikuks Clare Nancy Macpherson-Grant Russell, kelle kujundatud on kiviktaimla ja rosaarium. Lossi ajaloost, omanikest, ümberehitustest, ringkäigust lossis, pargist. 14 ill

Poster: A modern Python interface for the Generic Mapping Tools

OpenAIRE

Uieda, Leonardo; Wessel, Paul

2017-01-01

Poster presentation at the AGU Fall Meeting 2017.Abstract: IN51B-0018Inkscape source files for the poster and a Jupyter notebook with the demo are on the Github repository: github.com/leouieda/agu2017 The demo notebook can be run online using the MyBinder service: agu2017demo.gmtpython.xyzAbstractFigures generated by The Generic Mapping Tools (GMT) are present in countless publications across the Earth sciences. The command-line interface of GMT lends the tool its flexibility bu...

Fossilization of nanobes studied by transmission electron microscopy and constraints related to their population - Recent and Late Quaternary reefbanks (San Salvador Island, The Bahamas; Heron Island, Australia

Czech Academy of Sciences Publication Activity Database

Hladil, Jindřich; Gemperle, Antonín; Carew, J. L.; Bosák, Pavel; Slavík, Ladislav; Pruner, Petr; Charvatova, K.; Mylroie, J. E.; Jell, J. S.

2003-01-01

Roč. 5, Abstracts of the Contributions of the EGS-AGU-EUG Joint Assembly Nice. (2003), s. Abstract Number 05312 ISSN 1029-7006. [EGS-AGU-EUG Joint Assembly. 06.04.2003-11.04.2003, EGS-AGU-EUG Joint Assembly] R&D Projects: GA AV ČR IAA3013209 Institutional research plan: CEZ:AV0Z3013912 Keywords : microbial diagenesis * carbonate platforms * Quaternary Subject RIV: DB - Geology ; Mineralogy http://www.cosis.net/abstracts/EAE03/05312/EAE03-J-05312-1.pdf

Insight into glycoside hydrolases for debranched xylan degradation from extremely thermophilic bacterium Caldicellulosiruptor lactoaceticus.

Directory of Open Access Journals (Sweden)

Xiaojing Jia

Full Text Available Caldicellulosiruptor lactoaceticus 6A, an anaerobic and extremely thermophilic bacterium, uses natural xylan as carbon source. The encoded genes of C. lactoaceticus 6A for glycoside hydrolase (GH provide a platform for xylan degradation. The GH family 10 xylanase (Xyn10A and GH67 α-glucuronidase (Agu67A from C. lactoaceticus 6A were heterologously expressed, purified and characterized. Both Xyn10A and Agu67A are predicted as intracellular enzymes as no signal peptides identified. Xyn10A and Agu67A had molecular weight of 47.0 kDa and 80.0 kDa respectively as determined by SDS-PAGE, while both appeared as homodimer when analyzed by gel filtration. Xyn10A displayed the highest activity at 80 °C and pH 6.5, as 75 °C and pH 6.5 for Agu67A. Xyn10A had good stability at 75 °C, 80 °C, and pH 4.5-8.5, respectively, and was sensitive to various metal ions and reagents. Xyn10A possessed hydrolytic activity towards xylo-oligosaccharides (XOs and beechwood xylan. At optimum conditions, the specific activity of Xyn10A was 44.6 IU/mg with beechwood xylan as substrate, and liberated branched XOs, xylobiose, and xylose. Agu67A was active on branched XOs with methyl-glucuronic acids (MeGlcA sub-chains, and primarily generated XOs equivalents and MeGlcA. The specific activity of Agu67A was 1.3 IU/mg with aldobiouronic acid as substrate. The synergistic action of Xyn10A and Agu67A was observed with MeGlcA branched XOs and xylan as substrates, both backbone and branched chain of substrates were degraded, and liberated xylose, xylobiose, and MeGlcA. The synergism of Xyn10A and Agu67A provided not only a thermophilic method for natural xylan degradation, but also insight into the mechanisms for xylan utilization of C. lactoaceticus.

Analüütikud soovitavad Eesti Energia börsile viia / Piret Reiljan

Index Scriptorium Estoniae

Reiljan, Piret, 1983-

2008-01-01

Kohalikud analüütikud soovitavad viia Eesti Energia börsile, kuna see elavdaks aktsiaturgu ja tõmbaks ligi välisinvestoreid. Vt. samas: Raivo Vare: raske aeg töötab Eesti Energia börsiletoomise kasuks; Analüüs ootab pääsu valitsuskabinetti; Juhid ei püsi enam Eesti Energias. Diagrammid: Majandusnäitajad; Varade maht

[Määramised

Index Scriptorium Estoniae

2006-01-01

Ametisse määramised: Kaitseliidu ülem major Raivo Lumiste; Maaväe staabi ülem kolonelleitnant Indrek Sirel; Kaitsejõudude peastaabi personaliosakonna ülem kolonelleitnant Vahur Väljamäe; 1. jalaväebrigaadi ülem kolonelleitnant Artur Tiganik; Scoutspataljoni ülem major Aivar Kokka; Kaitseväe peakaplan major Taavi Laanepere. Haridus, sõjaline kvalifikatsioon, teenistuskäik, auastmed, autasud

Unest äratatud Alatskivi loss / Meeli Müüripeal, Sirje Pärismaa

Index Scriptorium Estoniae

Müüripeal, Meeli, 1963-

2005-01-01

Alatskivi lossist (Arved von Nolcken, 1880-1885), lossi restaureerimise käigust ja seisust. Korras on viis esindusruumi. Sisekujunduse autorid: Olev Suuder, Oleg Mellov, ARC Projekt. SA Alatskivi Loss plaanidest. Kommenteerivad sihtasutuse juhataja Külli Must, lossi taastamise eestvedajad restauraator Raivo Nisu ja senine vallavanem Maie Nisu, kes kaitses 2004. a. EKA-s magistritöö "Alatskivi mõisaansambli revitaliseerimise ideeprojekt". 14 ill

Uniprindi büroo- ja trükikojahoone : edu peatänavatest, Uniprindi trükikojast ning geneerilisest arhitektuurist = Success from Main Streets, Uniprint Printing Plant, and Generic Architecture / Veljo Kaasik

Index Scriptorium Estoniae

Kaasik, Veljo

2000-01-01

Pärnu mnt. ristmiku juurde Tallinnas R. Puusepa arhitektibüroo poolt trükikojale Uniprint projekteeritud büroo-tootmishoonest. Arhitektid Raivo Puusepp, Krista Väärtnõu. Konstruktsioonid: Projektbüroo Teinos, Civen OÜ. Projekt 1999-2000, hoone valmis 2000. Peatänavaid ääristava hoonestuse kiirest muundumisest. 9 ill.: korruste plaanid, lõiked, vaated (joon.); välisvaated (foto)

Eesti Meremuuseumi hoone Lennusadamas = Estonian Maritime Museum in the Tallinn Seaplane Harbour

Index Scriptorium Estoniae

2015-01-01

Eesti Meremuuseumi rekonstrueeritud vesilennukite angaarid Tallinnas Vesilennuki 6, valminud 2012. Eesti kultuurkapitali aastapreemia 2012. Arhitektid Raivo Kotov, Andrus Kõresaar, Indrek Mikk, Margit Aule, Tõnis Savi, Lea Laidra, Karis Kahr, Jelena Altmäe, Jaanus Männik (KOKO Arhitektid). Sisearhitektid Margit Argus, Andrus Kõresaar, Olga Batuhtina (KOKO Arhitektid). Raudbetoonkonstruktsioonide renoveerimisprojekt Karl Õiger, Heiki Onton (Tallinna Tehnikaülikool). Uued konstruktsioonid Neoprojekt

Kogukonnateatrist Eestis 2008. aasta näitel / Hedi-Liis Toome

Index Scriptorium Estoniae

Toome, Hedi-Liis

2009-01-01

Kogukonnateatri mõistest ja olemusest. Näiteid neljast lavastusest - Pärimusteatri Loomine "Pärija" (lav. Raivo Trass), MTÜ Tuulekella koostööprojekt Raasiku valla ja rahvamajaga "Ernesaks ja Oamats" (lav. Vahur Keller), Põltsamaa teatri Ellunäod lavastus "Rasputin" (lav. Ain Saviauk) ning rahvusvahelisel teatrifestivalil Baltoscandal 2008 esietendunud projekt "50 Lovely Ways to Die" (lav. Kaja Kann, Juha Valkeapää)

Fahle maja Tallinnas = Fahle building in Tallinn / Triin Ojari

Index Scriptorium Estoniae

Ojari, Triin, 1974-

2007-01-01

Tartu mnt. 84a asuva Fahle maja autorid: Raivo Kotov, Andrus Kõresaar. Arhitektuur: KOKO Arhitektid. Konstruktor: Ago Kuddu. Sisekujundus: Liis Lindvere, Raili Paling, Liisi Murula. Projekt 2002, valmis 2006. Pälvis Eesti Kultuurkapitali arhitektuuri sihtkapitali 2006. a. preemia - parim arhitektuurne objekt. Tallinna Kultuurivabriku rajamise mõttetalgutest. Lõige, I, VII ja XIV korruse plaanid, 4 välisvaadet, Koger & Partnerid kontor (sisearhitekt Lembit Tork)

Näitused kunstiakadeemias

Index Scriptorium Estoniae

2003-01-01

EKA galeriis näitusel "Kirju pall" esitavad "krutskilist ökokunsti" rühmitus Puhas Rõõm, Mart Viljus, Anu Vahtra, Maris Mändel, Katrin Tees, Reimo Võsa-Tangsoo, Erki Kasemets, Raivo Hool. Aula fuajees näeb Jaak Soansi juhendamisel valminud skulptuuriosakonna õppetöid, valdavalt poliitikute skulptuurportreid. Osalevad Kristiina Järvelaid, Jelena Levtshenkova, Rene Reinumäe, Kaisa Uusoksa, Marju Vaher

Kuni 20. VIII on Tallinnas vastavatud kultuuritehases Polymer ennast sisse seadnud...Rael Artel Gallery

Index Scriptorium Estoniae

2004-01-01

Näha saab G-Labi (Arturas Bumsteinas, Laura Garbstiene, Leedu) heliinstallatsiooni "Mirrors and Copulations", Kiwa heliteost "Hlör U Fang Axaxaxas mlö", Anu Allase kureeritud väljapanekut "Juhitud reisid/Guided Tours" (osalevad Liisi Peets, Katrin Tees, Piret Räni, Anu Vahtra, Daisy Lappard, rühmitus Tiit Sokk: Ulvi Tiit & Marili Sokk, Raivo Hool, Rataplan), Grace Schwindti (London) videot "Desire"

Evaluation of Novel 64Cu-Labeled Theranostic Gadolinium-Based Nanoprobes in HepG2 Tumor-Bearing Nude Mice

Science.gov (United States)

Hu, Pengcheng; Cheng, Dengfeng; Huang, Tao; Banizs, Anna B.; Xiao, Jie; Liu, Guobing; Chen, Quan; Wang, Yuenan; He, Jiang; Shi, Hongcheng

2017-09-01

Radiation therapy of liver cancer is limited by low tolerance of the liver to radiation. Radiosensitizers can effectively reduce the required radiation dose. AGuIX nanoparticles are small, multifunctional gadolinium-based nanoparticles that can carry radioisotopes or fluorescent markers for single-photon emission computed tomography (SPECT), positron emission tomography (PET), fluorescence imaging, and even multimodality imaging. In addition, due to the high atomic number of gadolinium, it can also serve as a tumor radiation sensitizer. It is critical to define the biodistribution and pharmacokinetics of these gadolinium-based nanoparticles to quantitate the magnitude and duration of their retention within the tumor microenvironment during radiotherapy. Therefore, in this study, we successfully labeled AGuIX with 64Cu through the convenient built-in chelator. The biodistribution studies indicated that the radiotracer 64Cu-AGuIX accumulates to high levels in the HepG2 xenograft of nude mice, suggesting that it would be a potential theranostic nanoprobe for image-guided radiotherapy in HCC. We also used a transmission electron microscope to confirm AGuIX uptake in the HepG2 cells. In radiation therapy studies, a decrease in 18F-FDG uptake was observed in the xenografts of the nude mice irradiated with AGuIX, which was injected 1 h before. These results provide proof-of-concept that AGuIX can be used as a theranostic radiosensitizer for PET imaging to guide radiotherapy for liver cancer.

Raivo Vare : "Politizatsija forsirovala jestestvennõje protsessõ v tranzitnom dele" / Raivo Vare ; interv. Aleksei Starkov

Index Scriptorium Estoniae

Vare, Raivo, 1958-

2007-01-01

Transiidiküsimuste ekspert vastab küsimustele transiitkaubanduse, Venemaa transiidi mõju kohta Eesti majandusele, Ust-Luga ja Sillamäe sadamate arengu, Läänemerre rajatava Vene-Saksa gaasijuhtme ja Eesti gaasivarustuse kohta

EGS Richardson AGU Chapman NVAG3 Conference: Nonlinear Variability in Geophysics: scaling and multifractal processes

Directory of Open Access Journals (Sweden)

D. Schertzer

1994-01-01

Full Text Available 1. The conference The third conference on "Nonlinear VAriability in Geophysics: scaling and multifractal processes" (NVAG 3 was held in Cargese, Corsica, Sept. 10-17, 1993. NVAG3 was joint American Geophysical Union Chapman and European Geophysical Society Richardson Memorial conference, the first specialist conference jointly sponsored by the two organizations. It followed NVAG1 (Montreal, Aug. 1986, NVAG2 (Paris, June 1988; Schertzer and Lovejoy, 1991, five consecutive annual sessions at EGS general assemblies and two consecutive spring AGU meeting sessions. As with the other conferences and workshops mentioned above, the aim was to develop confrontation between theories and experiments on scaling/multifractal behaviour of geophysical fields. Subjects covered included climate, clouds, earthquakes, atmospheric and ocean dynamics, tectonics, precipitation, hydrology, the solar cycle and volcanoes. Areas of focus included new methods of data analysis (especially those used for the reliable estimation of multifractal and scaling exponents, as well as their application to rapidly growing data bases from in situ networks and remote sensing. The corresponding modelling, prediction and estimation techniques were also emphasized as were the current debates about stochastic and deterministic dynamics, fractal geometry and multifractals, self-organized criticality and multifractal fields, each of which was the subject of a specific general discussion. The conference started with a one day short course of multifractals featuring four lectures on a Fundamentals of multifractals: dimension, codimensions, codimension formalism, b Multifractal estimation techniques: (PDMS, DTM, c Numerical simulations, Generalized Scale Invariance analysis, d Advanced multifractals, singular statistics, phase transitions, self-organized criticality and Lie cascades (given by D. Schertzer and S. Lovejoy, detailed course notes were sent to participants shortly after the

EGS Richardson AGU Chapman NVAG3 Conference: Nonlinear Variability in Geophysics: scaling and multifractal processes

Science.gov (United States)

Schertzer, D.; Lovejoy, S.

1. The conference The third conference on "Nonlinear VAriability in Geophysics: scaling and multifractal processes" (NVAG 3) was held in Cargese, Corsica, Sept. 10-17, 1993. NVAG3 was joint American Geophysical Union Chapman and European Geophysical Society Richardson Memorial conference, the first specialist conference jointly sponsored by the two organizations. It followed NVAG1 (Montreal, Aug. 1986), NVAG2 (Paris, June 1988; Schertzer and Lovejoy, 1991), five consecutive annual sessions at EGS general assemblies and two consecutive spring AGU meeting sessions. As with the other conferences and workshops mentioned above, the aim was to develop confrontation between theories and experiments on scaling/multifractal behaviour of geophysical fields. Subjects covered included climate, clouds, earthquakes, atmospheric and ocean dynamics, tectonics, precipitation, hydrology, the solar cycle and volcanoes. Areas of focus included new methods of data analysis (especially those used for the reliable estimation of multifractal and scaling exponents), as well as their application to rapidly growing data bases from in situ networks and remote sensing. The corresponding modelling, prediction and estimation techniques were also emphasized as were the current debates about stochastic and deterministic dynamics, fractal geometry and multifractals, self-organized criticality and multifractal fields, each of which was the subject of a specific general discussion. The conference started with a one day short course of multifractals featuring four lectures on a) Fundamentals of multifractals: dimension, codimensions, codimension formalism, b) Multifractal estimation techniques: (PDMS, DTM), c) Numerical simulations, Generalized Scale Invariance analysis, d) Advanced multifractals, singular statistics, phase transitions, self-organized criticality and Lie cascades (given by D. Schertzer and S. Lovejoy, detailed course notes were sent to participants shortly after the conference). This

Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector

Directory of Open Access Journals (Sweden)

Swati Singh

2017-03-01

Full Text Available Wiskott-Aldrich syndrome (WAS is a life-threatening immunodeficiency caused by mutations within the WAS gene. Viral gene therapy to restore WAS protein (WASp expression in hematopoietic cells of patients with WAS has the potential to improve outcomes relative to the current standard of care, allogeneic bone marrow transplantation. However, the development of viral vectors that are both safe and effective has been problematic. While use of viral transcriptional promoters may increase the risk of insertional mutagenesis, cellular promoters may not achieve WASp expression levels necessary for optimal therapeutic effect. Here we evaluate a self-inactivating (SIN lentiviral vector combining a chromatin insulator upstream of a viral MND (MPSV LTR, NCR deleted, dl587 PBS promoter driving WASp expression. Used as a gene therapeutic in Was−/− mice, this vector resulted in stable WASp+ cells in all hematopoietic lineages and rescue of T and B cell defects with a low number of viral integrations per cell, without evidence of insertional mutagenesis in serial bone marrow transplants. In a gene transfer experiment in non-human primates, the insulated MND promoter (driving GFP expression demonstrated long-term polyclonal engraftment of GFP+ cells. These observations demonstrate that the insulated MND promoter safely and efficiently reconstitutes clinically effective WASp expression and should be considered for future WAS therapy.

Pärnu hotell-veekeskus Tervise Paradiis / Tüüne-Kristin Vaikla

Index Scriptorium Estoniae

Vaikla, Tüüne-Kristin, 1961-

2005-01-01

Pärnus Side t. 14 asuva hotelli-veekeskuse arhitekt on Raivo Puusepp. Sisekujundus, logo, infograafika: Tüüne-Kristin ja Urmo Vaikla, OÜ Vaikla Stuudio. Ehitaja: AS Merko Ehitus. Hotellitubade mööbel ja valamud, retseptsioonide letid, restorani-baaride lauad, sohvad, lobby vaibad on kavandatud spetsiaalselt sellele objektile. T.-K. ja U. Vaiklast, Vaikla Stuudio sisearhitektuurseid töid. Ill.: plaan, 28 värv. vaadet

Chuck Jones lahkus, tema kangelased elavad edasi / Neeme Korv

Index Scriptorium Estoniae

Korv, Neeme, 1974-

2002-01-01

Suri Chuck Jones (1912-2002), kuulus USA animafilmirežissöör, kelle animasari "Tom & Jerry" on praegugi Eestis väga populaarne. Ta on loonud enam kui 300 animafilmi, saanud 3 Oscarit ning 1996. aastal ka elutöö Oscari. Eesti lapsed nägid nõukogude ajal esmakordselt Chuck Jones'i loomingut Raivo Järvi lastesaadetes "Laupäeval koos isaga"

Linnateater sai ruumi juurde / Ester Shank

Index Scriptorium Estoniae

Šank, Ester, 1956-

1999-01-01

27. III lisanduvad Lai 23 asuvale Tallinna Linnateatri väikesele saalile naabermajad Lai 21 ja Lai 19 / Aida 2, millega on realiseeritud esimene osa uue teatrimaja ehitusprojektist. Projekti autor Kalle Rõõmus. Sisekujundajad Argo ja Katrin Vaikla. Teatritehnoloogia: Mikko Hausmann Soomest. Peatöövõtja Estconde-E. Kogu projektist, vastvalminud osast, ehitusloost. Kommenteerivad K. Rõõmus, teatri direktor Raivo Põldmaa, projektijuht Liivo Kruusel. 8 ill

Novõi muzei na vzljotnoi polose / Villu Päärt

Index Scriptorium Estoniae

Päärt, Villu, 1972-

2006-01-01

Eesti Rahva Muuseumi uue hoone ideekonkursi võidutööst räägivad muuseumi endine direktor Jaanus Plaat, üks autoreid Lina Ghotmeh ja kultuuriminister Raivo Palmaru. Nimetatud kolm võidutööd autoritega. Lisaks eesti arhitektide osalemisest "Estontsam dostalas lish odna premija". Preemiasaajate hulgas olid arhitektid büroost Kosmos (Ott Kadarik, Villem Tomiste, Mihkel Tüür, Krista Saluveer, Urmas Oja)

Corelli Music Sügis 2008 - Jaapanist Veneetsiani

Index Scriptorium Estoniae

2008-01-01

Jaapani klavessinistist Yoshiko Iekist, kontsertidest 8. sept. Tallinnas ja 10. sept. Maardu mõisas sarjas "Maardu mõisa muusikasalong" (Y. Ieki ansamblipartneriks on viiuldaja Mail Sildos). Kava "Vivaldi, Casanova ja Veneetsia" esitusest 15. okt. Maardus sarjas "Maardu mõisa muusikasalong", 18. okt. Pärnu hotellis Victoria sarjas "Café Grand muusikasalong" ja 19. okt. Tallinnas sarjas "Toompea Muusikasalong" (esineb barokkansambel Corelli Consort, kommenteerib kunstnik Raivo Järvi)

The Efforts of the American Geophysical Union Space Physics and Aeronomy Section Education and Public Outreach Committee to Use NASA Research in Education and Outreach

Science.gov (United States)

Bering, E. A., III; Dusenbery, P.; Gross, N. A.; Johnson, R.; Lopez, R. E.; Lysak, R. L.; Moldwin, M.; Morrow, C. A.; Nichols-Yehling, M.; Peticolas, L. M.; Reiff, P. H.; Scherrer, D. K.; Thieman, J.; Wawro, M.; Wood, E. L.

2017-12-01

The American Geophysical Union Space Physics and Aeronomy Section Education and Public Outreach Committee (AGU SPA-EPO Committee) was established in 1990 to foster the growth of a culture of outreach and community engagement within the SPA Section of the AGU. The SPA was the first AGU Section to establish an EPO Committee. The Committee has initiated several key Section EPO programs that have grown to become Union programs. NASA sponsored research is central to the mission of the SPE-EPO. Programs highlighting NASA research include the Student Paper Competition, Exploration Station, a precursor to the GIFT workshops, the Student mixer, and more. The Committee played a key role in coordinating the AGU's outreach activities relating to the International Heliophysical Year in 2007-2008. This paper will review the triumphs, the failures, and the lessons learned about recruiting colleagues to join with us from the last quarter century of effort.

Transition to electronic publishing

Science.gov (United States)

Bowning, Sam

Previous communications have described some of the many changes that will occur in the next few months as AGU makes the transition to fully electronic publishing. With the advent of the new AGU electronic publishing system, manuscripts will be submitted, edited, reviewed, and published in electronic formats. This piece discusses how the electronic journals will differ from the print journals. Electronic publishing will require some adjustments to the ways we currently think about journals from our perspective of standard print versions. Visiting the Web site of AGU's Geochemistry, Geophysics, Geosystems (G-Cubed) is a great way to get familiar with the look and feel of electronic publishing. However, protocols, especially for citations of articles, are still evolving. Some of the biggest changes for users of AGU publications may be the lack of page numbers, the use of a unique identifier (DOI),and changes in citation style.

Ag/MnO₂ Nanorod as Electrode Material for High-Performance Electrochemical Supercapacitors.

Science.gov (United States)

Guo, Zengcai; Guan, Yuming; Dai, Chengxiang; Mu, Jingbo; Che, Hongwei; Wang, Guangshuo; Zhang, Xiaoliang; Zhang, Zhixiao; Zhang, Xiliang

2018-07-01

A one-dimensional hierarchical Ag nanoparticle (AgNP)/MnO2 nanorod (MND) nanocomposite was synthesized by combining a simple solvothermal method and a facile reduction approach in situ. Owing to its high electrical conductivity, the resulting AgNP/MND nanocomposite displayed a high specific capacitance of 314 F g-1 at a current density of 2 A g-1, which was much higher than that of pure MNDs (178 F g-1). Resistances of the electrolyte (Rs) and charge transportation (Rct) of the nanocomposite were much lower than that of pure MNDs. Moreover, the nanocomposite exhibited outstanding long-term cycling ability (9% loss of initial capacity after 1000 cycles). These results indicated that the nanocomposite could serve as a promising and useful electrode material for future energy-storage applications.

Minor neurological dysfunction and cognition in 9-year-olds born at term

NARCIS (Netherlands)

Kikkert, Hedwig K; de Jong, Corina; Hadders-Algra, Mijna

BACKGROUND: In children with developmental disorders, motor problems often co-occur with cognitive difficulties. Associations between specific cognitive deficits underlying learning problems and minor neurological dysfunction (MND) are still unknown. AIMS: To assess associations between specific

Uljas uus vana maailm / Raivo Kelomees

Index Scriptorium Estoniae

Kelomees, Raivo, 1960-

2004-01-01

Meediakunstniku staatusest postsotsialistlikus ühiskonnas, sõltuvusest ja ebamäärasusest transformeeruvas kunstitehnoloogilises keskkonnas, kus vastuolud ja üksteisemõistmine on lähemal vaatlusel paiguti ületamatud, arvamusfoon on muutuv ning kaootiline, kohati kanoniseeruv ning kommunikatsioon tihti negatiivne

40 aastat uurivat õpetajat / Raivo Juurak

Index Scriptorium Estoniae

Juurak, Raivo, 1949-

2001-01-01

ÜPUI asutamisest, minevikust ja ka tulevikust. Vestlusringis on Ühiskondliku Pedagoogika Uurimise Instituudi asutajad ja eestvedajad - Helme kutsekooli õpetaja Peep Leppik, TÜ kasvatusteaduste dotsent Inger Kraav, TPÜ emeriitprofessor Inge Unt, TPÜ dotsent Viivi Maanso

Kas Eesti vajab alternatiivharidust? / Raivo Juurak

Index Scriptorium Estoniae

Juurak, Raivo

2001-01-01

TPÜ ja Haridusfoorum korraldasid 24.-27. maini 2001 Tallinnas EFFE (European Forum for Freedom in Education) konverentsi arutamaks hariduse ja vabaduse seoseid. Lisaks eestlastele osalesid Saksamaa, Soome, Taani, Austria, Šveitsi, Hollandi jt maade hariduseksperdid. EFFE on üleeuroopaline vabatahtlik organisatsioon, mis ühendab alternatiivpedagoogilisi liikumisi, taotleb alternatiive hariduses ja toetab õpetaja loominguvabadust. Konverentsil võtsid sõna TPÜ õppejõud T. Kuurme, TPÜ täienduskoolituse osakonnast J. Košelev, TPÜ haridusuuringute instituudi direktor S. Priimägi jt.

Interaktiivne meedia ja film / Raivo Kelomees

Index Scriptorium Estoniae

Kelomees, Raivo, 1960-

2005-01-01

25.-30. IV Tartu Kõrgemas Kunstikoolis toimunud rahvusvahelisest interaktiivse filmi workshopist "Mediamatic Interactive Film Lab", mis algas sümpoosioniga Tartu Ülikooli raamatukogu konverentsikeskuses

Vajame arengut toetavat kooli / Raivo Juurak

Index Scriptorium Estoniae

Juurak, Raivo, 1949-

2012-01-01

Suurbritannia haridusprogrammist, kus õpilase arengut koolis maksimaalselt toetakse. Canterbury ülikooli haridusteaduskonna programmi „Kvaliteet õppe toetamisel” ehk QiSS (Quality in Study Support) direktori Linda Leith'i intervjuu põhjal

Internetikasiinodel ähmane tulevik / Raivo Sormunen

Index Scriptorium Estoniae

Sormunen, Raivo, 1976-

2006-01-01

Ilmunud ka: Delovõje Vedomosti 16. aug. lk. 25. Autor analüüsib online-hasartmänguturul toimuvaid aktsiate liikumisi ja tendentse. Tabel: Online-kasiinooperaatorite aktsiad löögi all. Diagramm: PartyGamingu aktsia pole rahulikule investorile. Vt. samas: Jamad ka Euroopa Liidus

Intellektika 2001 - Tartu "Teeviit" / Raivo Juurak

Index Scriptorium Estoniae

Juurak, Raivo

2001-01-01

16.-17. veebr. 2001 toimus Tartus haridus- ja teadusmess "Intellektika 2001", kus osales 291 hariduse ja teadusega seotud organisatsiooni. Kuna osalejate seas oli rohkesti õppeasutusi, nimetati messi ka Tartu "Teeviidaks"

Miks koolis diskrimineeritakse poisse? / Raivo Juurak

Index Scriptorium Estoniae

Juurak, Raivo, 1949-

2015-01-01

Eelmisel aastal peetud soolise võrdõiguslikkuse konverentsi sõnumiks on, et Eesti koolis diskrimineerivad õpetajad poisse. Küsimusele, kuidas poisid tüdrukutele järele aidata, vastavad Tallinna prantsuse lütseumi õpetaja Anneli Oidsalu, TLÜ kasvatusteaduste õppejõud Tiiu Kuurme, psühholoog Tiia Lister, haridustöötaja Enn Veesalu ja õpetaja Lembit Jakobson

Irma Optimisti "Female mathematics" / Raivo Kelomees

Index Scriptorium Estoniae

Kelomees, Raivo, 1960-

2007-01-01

Irma Optimisti näitusest "Female mathematics" Helsingis Muu-galeriis, mis on osa projektist "Mõistelisus ja käsitöölikkus (Käsitteellisyys ja käsityöläisyys) ehk naine ja tehnoloogia". Ilmunud ka ajalehes "Eesti Päevaleht", 1996, 27. veebruar

Investorid ootavad 14. augustit / Raivo Sormunen

Index Scriptorium Estoniae

Sormunen, Raivo, 1976-

2002-01-01

Ilmunud ka: Delovõje Vedomosti 7. august. lk. 22. 14. augustiks peavad ligi tuhande USA suurima avaliku firma juhid kinnitama riigi väärtpaberi- ja järelevalveorganisatsioonile (SEC) oma finantsaruannete ausust ja täpsust. Raamatupidamisseaduse muudatustest. Tabel: Raamatupidamise loomingulisus moonutab ettevõtete tulemusi

Dividend tõstab hinda / Raivo Sormunen

Index Scriptorium Estoniae

Sormunen, Raivo, 1976-

2010-01-01

Autori sõnul on investorid ülimadalale vajunud intressimäärade tingimustes hakanud maksma väga kõrget hinda dividendiaktsiate eest ning jätnud tähelepanuta ettevõtete kasumiteenimise potentsiaali

Virtuaalreaalsuse sensuaalne hõivamine / Raivo Kelomees

Index Scriptorium Estoniae

Kelomees, Raivo, 1960-

2007-01-01

Mõtteid seoses Char Daviese (1954) virtuaalreaalsuse installatsiooni "Osmoos" nägemisega Montreali Moodsa Kunsti Muuseumis. Ka Heidi Tikka artiklist "Cyberspace - a feminist point of view". Ilmunud ka ajalehes "Sirp", 1997, 4. aprill

Kehamasinmeedia : scratch ja remiks / Raivo Kelomees

Index Scriptorium Estoniae

Kelomees, Raivo, 1960-

2000-01-01

Kehalisus kunstis, selle erinevad väljandusliigid, virtuaalsed mängud. Donna Haraway küborgi definitsioonist. Küborgi tüübid. CMC - Computer Mediated Communication'i võimalusest eksperimenteerida erinevate eneseesitlustega

Quo vadis, emakeeleõpetus? / Raivo Juurak

Index Scriptorium Estoniae

Juurak, Raivo

2006-01-01

Ülevaade TLÜ-s toimunud Emakeeleõpetuse Infokeskuse teabepäevast, kus osalesid eesti keele ja kirjanduse õpetajad ning TLÜ keele- ja kirjandusteadlased. Lähemalt Rocca al Mare õpetaja J. Vaiksoo, TLÜ dotsendi K. Kerge ja Haridus- ja Teadusministeeriumi nõuniku J. Valge sõnavõttudest

Ida-igatsuse põhjapiir / Raivo Paltser

Index Scriptorium Estoniae

Paltser, Raivo

2006-01-01

Hiina traditsiooni järgija R. Paltseri nägemus Lääne inimese ihalusest Vana-Hiina kultuuri järele, kung-fust. Toodud mõningaid näiteid Soome ja Hiina mütoloogiat ühendavast fantaasiafilmist "Igavese armastuse sõdalane - Jade Warrior"

WE-FG-BRA-07: Theranostic Nanoparticles Improve Clinical MR-Guided Radiation Therapy

Energy Technology Data Exchange (ETDEWEB)

Detappe, A [Dana-Farber Cancer Institute, Boston, MA (United States); Institut Lumiere-Matiere, Lyon, FR (France); Kunjachan, S; Berbeco, R [Dana-Farber Cancer Institute, Boston, MA (United States); Sancey, L; Motto-Ros, V; Tillement, O [Institut Lumiere-Matiere, Lyon, FR (France)

2016-06-15

Purpose: MR-guided radiation therapy is a current and emerging clinical reality. We have designed and tested a silica-based gadolinium chelates nanoparticle (AGuIX) for integration with MR-guided radiation therapy. The AGuIX nanoparticles used in this study are a dual-modality probe with radiosensitization properties and better MRI contrast than current FDA-approved gadolinium chelates. In advance of an approved Phase I clinical trial, we report on the efficacy and safety in multiple animal models and clinically relevant radiation conditions. By modeling our study on current clinic workflows, we show compatibility with modern patient care, thus heightening the translational significance of this research. Methods: The dual imaging and therapy functionality of AGuIX was investigated in mice with clinical radiation beams while safety was evaluated in mice, and nonhuman primates after systemic injection of 0.25 mg/g of nanoparticles. MRI/ICP-MS were used to measure tumor uptake and biodistribution. Due to their small size (2–3 nm), AGuIX have good renal clearance (t1/2=19min). We performed in vitro cell uptake quantification and radiosensitization studies (clonogenic assays and DNA damage quantification). In vivo radiation therapy studies were performed with both 6MV and 6MV-FFF clinical radiation beams. Histology was performed to measure the increase in DNA damage in the tumor and to evaluate the toxicity in healthy tissues. Results: In vitro and in vivo results demonstrate statistically significant increase (P < 0.01) in DNA damage, tumor growth supression and survival (+100 days) compared to radiation alone. Negligible toxicity was observed in all of the animal models. The combination of 6MV-FFF/AGuIX demonstrated a substantial dose enhancement compared to 6MV/AGuIX (DEF = 1.36 vs. 1.22) due to the higher proportion of low energy photons. Conclusion: With demonstrated efficacy and negligible toxicity in mice and non-human primates, AGuIX is a biocompatible

WE-FG-BRA-07: Theranostic Nanoparticles Improve Clinical MR-Guided Radiation Therapy

International Nuclear Information System (INIS)

Detappe, A; Kunjachan, S; Berbeco, R; Sancey, L; Motto-Ros, V; Tillement, O

2016-01-01

Purpose: MR-guided radiation therapy is a current and emerging clinical reality. We have designed and tested a silica-based gadolinium chelates nanoparticle (AGuIX) for integration with MR-guided radiation therapy. The AGuIX nanoparticles used in this study are a dual-modality probe with radiosensitization properties and better MRI contrast than current FDA-approved gadolinium chelates. In advance of an approved Phase I clinical trial, we report on the efficacy and safety in multiple animal models and clinically relevant radiation conditions. By modeling our study on current clinic workflows, we show compatibility with modern patient care, thus heightening the translational significance of this research. Methods: The dual imaging and therapy functionality of AGuIX was investigated in mice with clinical radiation beams while safety was evaluated in mice, and nonhuman primates after systemic injection of 0.25 mg/g of nanoparticles. MRI/ICP-MS were used to measure tumor uptake and biodistribution. Due to their small size (2–3 nm), AGuIX have good renal clearance (t1/2=19min). We performed in vitro cell uptake quantification and radiosensitization studies (clonogenic assays and DNA damage quantification). In vivo radiation therapy studies were performed with both 6MV and 6MV-FFF clinical radiation beams. Histology was performed to measure the increase in DNA damage in the tumor and to evaluate the toxicity in healthy tissues. Results: In vitro and in vivo results demonstrate statistically significant increase (P < 0.01) in DNA damage, tumor growth supression and survival (+100 days) compared to radiation alone. Negligible toxicity was observed in all of the animal models. The combination of 6MV-FFF/AGuIX demonstrated a substantial dose enhancement compared to 6MV/AGuIX (DEF = 1.36 vs. 1.22) due to the higher proportion of low energy photons. Conclusion: With demonstrated efficacy and negligible toxicity in mice and non-human primates, AGuIX is a biocompatible

Uus trükis / Ave Randviir

Index Scriptorium Estoniae

Randviir, Ave, 1981-

2009-01-01

Tutvustatakse 2009. aastal ilmunud kunstiraamatuid: Leonhard Lapin : merkit ja tyhjyys; Johannes Uiga. Pühajärve maalija; Ülo Õun. Kunstnik katkeval avastusrajal; Hotell Pärnu. Rael Artel gallery; Rühmitused : koostöö võimalikkusest kaasaegses Eesti kunstis; Andy Warholi filosoofia; Me näeme teid. Foksal galerii tegevus 1966-1989; Raivo Kelomees. Postmateriaalsus kunstis; Mall. Nukke. Kollaažid; XxX ehk Artishoki aastanäitus (võrguteavik)

Teatriekspressiga Äksist Põltsamaale / Riina Mägi

Index Scriptorium Estoniae

Mägi, Riina, 1957-

2007-01-01

Jõgevamaa harrastus- ja projektitruppide vabaõhulavastuste esietendustest 2006. aastal : Priit Aimla "Saadjärve saamise lugu" (Tabivere Harrastusteater, lavastaja Tõnis Lepp), Oskar Lutsu loomingust inspireeritud Veiko Märka "Sabani sõlmes Luts" (Palamuse Amatöörteater, lavastaja Raivo Adlas), Marina Carri "Kassirabal" projektitrupi esituses, lavastaja Ain Saviauk, Mati Tiku "Legend" (Saare Valla Metsateater, lavastaja autor), Ain Saviaugu "Ulm ehk Unistus Liivimaast" (Põltsamaa teater Ellunäod, lavastaja autor)

Uudised : Tüüri esiettekanne Frankfurdis. Corelli Musicult "Jõulud mõisas"

Index Scriptorium Estoniae

2006-01-01

22., 23. ja 24. nov. Frankfurdi Alte Operis esiettekandele tulevast Erkki-Sven Tüüri uuest "Klaverikontserdist". Eesti-Tšiili trio Raivo Tafenau - Meelis Vind - Ricardo Padilla kontsertidest sarja "Mõisaromantika" raames 25. nov. Taagepera lossis Valgamaal, 26. nov. Tõstamaa mõisas Pärnumaal ja 16. dets. Vihterpalu mõisas Harjumaal. Hans Neuenfelsi lavastatud Mozarti ooperist "Idemeneo" Deutsche Operis Berliinis. Inglise ansambli Procol Harumi hiti "A Whiter Shade of Pale" autoriõigustest

My NASA Data

Data.gov (United States)

National Aeronautics and Space Administration — MY NASA DATA (MND) is a tool that allows anyone to make use of satellite data that was previously unavailable.Through the use of MND’s Live Access Server (LAS) a...

Multimodal structural MRI in the diagnosis of motor neuron diseases.

Science.gov (United States)

Ferraro, Pilar M; Agosta, Federica; Riva, Nilo; Copetti, Massimiliano; Spinelli, Edoardo Gioele; Falzone, Yuri; Sorarù, Gianni; Comi, Giancarlo; Chiò, Adriano; Filippi, Massimo

2017-01-01

This prospective study developed an MRI-based method for identification of individual motor neuron disease (MND) patients and test its accuracy at the individual patient level in an independent sample compared with mimic disorders. 123 patients with amyotrophic lateral sclerosis (ALS), 44 patients with predominantly upper motor neuron disease (PUMN), 20 patients with ALS-mimic disorders, and 78 healthy controls were studied. The diagnostic accuracy of precentral cortical thickness and diffusion tensor (DT) MRI metrics of corticospinal and motor callosal tracts were assessed in a training cohort and externally proved in a validation cohort using a random forest analysis. In the training set, precentral cortical thickness showed 0.86 and 0.89 accuracy in differentiating ALS and PUMN patients from controls, while DT MRI distinguished the two groups from controls with 0.78 and 0.92 accuracy. In ALS vs controls, the combination of cortical thickness and DT MRI metrics (combined model) improved the classification pattern (0.91 accuracy). In the validation cohort, the best accuracy was reached by DT MRI (0.87 and 0.95 accuracy in ALS and PUMN vs mimic disorders). The combined model distinguished ALS and PUMN patients from mimic syndromes with 0.87 and 0.94 accuracy. A multimodal MRI approach that incorporates motor cortical and white matter alterations yields statistically significant improvement in accuracy over using each modality separately in the individual MND patient classification. DT MRI represents the most powerful tool to distinguish MND from mimic disorders.

Multimodal structural MRI in the diagnosis of motor neuron diseases

Directory of Open Access Journals (Sweden)

Pilar M. Ferraro

2017-01-01

Full Text Available This prospective study developed an MRI-based method for identification of individual motor neuron disease (MND patients and test its accuracy at the individual patient level in an independent sample compared with mimic disorders. 123 patients with amyotrophic lateral sclerosis (ALS, 44 patients with predominantly upper motor neuron disease (PUMN, 20 patients with ALS-mimic disorders, and 78 healthy controls were studied. The diagnostic accuracy of precentral cortical thickness and diffusion tensor (DT MRI metrics of corticospinal and motor callosal tracts were assessed in a training cohort and externally proved in a validation cohort using a random forest analysis. In the training set, precentral cortical thickness showed 0.86 and 0.89 accuracy in differentiating ALS and PUMN patients from controls, while DT MRI distinguished the two groups from controls with 0.78 and 0.92 accuracy. In ALS vs controls, the combination of cortical thickness and DT MRI metrics (combined model improved the classification pattern (0.91 accuracy. In the validation cohort, the best accuracy was reached by DT MRI (0.87 and 0.95 accuracy in ALS and PUMN vs mimic disorders. The combined model distinguished ALS and PUMN patients from mimic syndromes with 0.87 and 0.94 accuracy. A multimodal MRI approach that incorporates motor cortical and white matter alterations yields statistically significant improvement in accuracy over using each modality separately in the individual MND patient classification. DT MRI represents the most powerful tool to distinguish MND from mimic disorders.

Amyotrophic lateral sclerosis or not: Keys for the diagnosis.

Science.gov (United States)

Lenglet, T; Camdessanché, J-P

2017-05-01

Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron disease (MND) which prognosis is poor. Early diagnosis permit to set up immediately adapted treatment and cares. Available diagnostic criteria are based on the detection of both central and peripheral motor neuron injury in bulbar, cervical, thoracic and lumbar regions. Electrodiagnostic (EDX) tests are the key tools to identify peripheral motor neuron involvement. Needle examination records abnormal activities at rest, and looks for neurogenic pattern during muscle contraction. Motor unit potentials morphology is modified primary to recruitment. Motor evoked potentials remain the test of choice to identify impairment of central motor neurons. In the absence of diagnostic biomarker of ALS and among essential investigations of suspected MND, a careful clinical and neurophysiological work-up is essential to rule out the differential diagnosis. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Putrescine biosynthesis in Lactococcus lactis is transcriptionally activated at acidic pH and counteracts acidification of the cytosol.

Science.gov (United States)

Del Rio, Beatriz; Linares, Daniel; Ladero, Victor; Redruello, Begoña; Fernandez, Maria; Martin, Maria Cruz; Alvarez, Miguel A

2016-11-07

Lactococcus lactis subsp. cremoris CECT 8666 is a lactic acid bacterium that synthesizes the biogenic amine putrescine from agmatine via the agmatine deiminase (AGDI) pathway. The AGDI genes cluster includes aguR. This encodes a transmembrane protein that functions as a one-component signal transduction system, the job of which is to sense the agmatine concentration of the medium and accordingly regulate the transcription of the catabolic operon aguBDAC. The latter encodes the proteins necessary for agmatine uptake and its conversion into putrescine. This work reports the effect of extracellular pH on putrescine biosynthesis and on the genetic regulation of the AGDI pathway. Increased putrescine biosynthesis was detected at acidic pH (pH5) compared to neutral pH. Acidic pH induced the transcription of the catabolic operon via the activation of the aguBDAC promoter PaguB. However, the external pH had no significant effect on the activity of the aguR promoter PaguR, or on the transcription of the aguR gene. The transcriptional activation of the AGDI pathway was also found to require a lower agmatine concentration at pH5 than at neutral pH. Finally, the following of the AGDI pathway counteracted the acidification of the cytoplasm under acidic external conditions, suggesting it to provide protection against acid stress. Copyright © 2016 Elsevier B.V. All rights reserved.

Neurological condition assessed with the Hempel examination and cognition and behaviour at 4 years

NARCIS (Netherlands)

Schendelaar, Pamela; Seggers, Jorien; Heineman, Maas Jan; Hadders-Algra, Mijna

Aim: To investigate associations between neurological condition, assessed with the Hempel examination, in terms of minor neurological dysfunction (MND) and neurological optimality, and cognition and behaviour at 4 years. Study design: Cross-sectional analyses within a prospective, assessor-blinded

AGU testifies on NASA Budget

Science.gov (United States)

Simarski, Lynn Teo

Witnesses from outside the U.S. government—including Frank Eden, representing AGU—testified about the National Aeronautics and Space Administration's budget on March 12 before the House Science Committee's subcommittee on space. One major topic of the hearing was familiar: what should NASA's top priority be, space science or human exploration of space.“Obviously this committee has a huge job of trying to set priorities—consistent with the budget restraints—that will end up giving the American taxpayer the most bang for his buck, as well as providing direction for our space program,” said F. James Sensenbrenner, Jr. (R-Wis.), the subcommittee's ranking Republican. Another recurring topic, cited by the subcommittee's new chairman, Ralph M. Hall (D-Tex.), as well as by other committee members, was how to translate NASA-developed technologies into commercial gain for the U.S. in the global marketplace. Hall and others also posed a number of questions on a topic the chairman called a special concern of his: whether it would be economically and scientifically plausible for the U.S. to use the Soviet space station Mir for certain activities, such as medical applications.

Pacific Northwest regional AGU meeting

Science.gov (United States)

Hyndman, Roy

The 27th Annual Pacific Northwest Regional American Geophysical Union Meeting, held September 25 and 26, 1980, was hosted by the Pacific Geoscience Centre at the Institute of Ocean Sciences, near Victoria, British Columbia. A total of 79 papers was presented to the 150 registrants in six general sessions: seismology; electromagnetic induction; general geophysics; volcanology; hydrology; and oceanography, and in three special symposia: ‘The Queen Charlotte-Fairweather fault system and other active faults of the Pacific Northwest’ ‘Coastal circulation in the northeast Pacific’ and ‘Studies of the eruption of Mount St. Helens.’

Pain in Neurodegenerative Disease : Current Knowledge and Future Perspectives

NARCIS (Netherlands)

de Tommaso, Marina; Arendt-Nielsen, Lars; Defrin, Ruth; Kunz, Miriam; Pickering, Gisele; Valeriani, Massimiliano

2016-01-01

Neurodegenerative diseases are going to increase as the life expectancy is getting longer. The management of neurodegenerative diseases such as Alzheimer's disease (AD) and other dementias, Parkinson's disease (PD) and PD related disorders, motor neuron diseases (MND), Huntington's disease (HD),

Aerobic exercise and congnitive behavioural therapy in ALS: optimzing quality of life

NARCIS (Netherlands)

van der Lans-van Groenestijn, A.C.

2017-01-01

Amyotrophic lateral sclerosis (ALS) is a fatal progressive adult-onset neurodegenerative motor neuron disease (MND). In the absence of an effective treatment, ALS care focuses on symptom treatment, optimizing functioning (daily activities and social participation) and maintaining quality of life

Aitab hädaldamisest / Robert Antropov

Index Scriptorium Estoniae

Antropov, Robert, 1965-

2006-01-01

Endine politseijuht on seisukohal, et politseinike ja päästjate nappuses ei saa süüdistada ainult väikseid palku, küsimus on valikutes: kuidas ja millesse ressursse paigutada. Kalle Laanet ja Raivo Aeg vastavad küsimusele, mis on nende haldusalas konkreetselt kavas, et politsei saaks täita oma tegevusprioriteeti 100% ja tagada sisejulgeoleku. Vt. ka Robert Antropovi kommentaari 7. aug. Eesti Päevaleht lk. 2

Margus Linnamäe ostab Magnumi endale tagasi / Kadi Heinsalu

Index Scriptorium Estoniae

Heinsalu, Kadi, 1966-

2007-01-01

Ravimifirma Magnum asutaja Margus Linnamäe ostab kolm aastat tagasi välisinvestori kätte läinud suurosaluse firmast uuesti endale. Vt. samas: Magnum sündis kaupade vahendamisest; Tänavune aasta algas Magnumil firmade ostude ja suurte investeeringutega; Suur tulevikuäri koerte-Actimeliga; Tamro juht Tarvo Vaasa: olen üllatunud; Linnamäe rahaga kerkib eakatekodu; Margus Linnamäe kinnisvarahuvid. Diagramm: Magnumi majandusnäitajad. Kommenteerib Raivo Sormunen

Mida teeks tulevane kultuuriminister 500 miljoni krooniga? / interv. Andres Keil

Index Scriptorium Estoniae

2007-01-01

Suuremate erakondade kultuurispetsialistid (kultuuriministrikandidaadid) Urmas Paet, Andres Herkel, Peeter Jalakas, Indrek Saar, Jaak Allik, samuti kultuuriminister Raivo Palmaru vastavad küsimustele, mis on suurimad ohud eesti keele ja rahvuskultuuri säilimisele, milline on kultuuriministeeriumi ja -ministri portfelli staatus praeguses valitsuses, kas kultuuri rahastamine riigieelarvest on piisav, mille poolest erineb nende erakonna nägemus kultuuripoliitikast teiste erakondade omast, kuhu nad suunaksid 50, 500 miljonit, kui see oleks nende käsutuses

Kuldala elamurajoon : Rae vald, Harjumaa = Kuldala Residential Community : Rae municipality, Harju County / Triin Ojari

Index Scriptorium Estoniae

Ojari, Triin, 1974-

2008-01-01

Arhitektuurne projekt: KOKO Arhitektid. Kutsutud konkurss 2004, autorid: Lembit-Kaur Stöör, Margus Maiste, Raivo Kotov, Tõnis Kimmel. Hoonete projekteerimine: Lembit-Kaur Stöör, Margus Maiste, Olga Batuhtina. Maastikuarhitektuur: Margit Kärner. Projekt: 2005-2006. Lembit-Kaur Stöör arhitektuurikonkursist, planeeringust, elamute arhitektuurist, fassaadidest, ehitusest, sisehoovist. Joonised: vaade, I-IV korruse plaan (2), planeeringu makett, 5 värv. fotot: 3 välis- ja 2 sisevaadet

Muutuv ruum : meediakunst eesti kultuuris = Changing spaces : new media art in Estonian culture / Katrin Kivimaa

Index Scriptorium Estoniae

Kivimaa, Katrin, 1969-

2004-01-01

1990-ndate aastate Eesti kaasaegse kunsti arengust, selle medialiseerumisest, mida iseloomustab fotograafia, video ja arvutipõhise meedia tungimisest "kõrgesse kunsti", Mall Nukke, Tiia Johannsoni, Raivo Kelomehe ja Nelli Rohtvee netiprojektidest ning Ando Keskküla kureeritud rahvusvahelistest kunsti- ja meediaüritustest "Interstanding"1-3, ka Prantsuse-Balti videofestivalidest, uue meedia festivalist "Offline@online". Eestikeelne lühem variant ilmunud ajakirjas "Kunst.ee", 2001, nr.4, inglisekeelne - ajakirjas "Mare Articum", 2000, nr. 2(7)?

Film kui mälestus / Alina Kurvits

Index Scriptorium Estoniae

Kurvits, Alina

2003-01-01

Dokumentaalfilm "Pildi sisse minek" kunstnik Agu Pildist : režissöör, operaator, monteerija Marianne Kõrver : produtsent Peeter Urbla : Exitfilm 2002. Lisatud "Dialoogid ühevaatuselisest näidendist "Anna mulle põhjus siia jäämiseks"", kus Alina Kurvits, Marianne Kõrver, Urmas Muru, Urve Eslas ja Agu Pilt vestlevad filmi tegemisest, kunstniku identiteedist

In situ enzyme aided adsorption of soluble xylan biopolymers onto cellulosic material.

Science.gov (United States)

Chimphango, Annie F A; Görgens, J F; van Zyl, W H

2016-06-05

The functional properties of cellulose fibers can be modified by adsorption of xylan biopolymers. The adsorption is improved when the degree of biopolymers substitution with arabinose and 4-O-methyl-glucuronic acid (MeGlcA) side groups, is reduced. α-l-Arabinofuranosidase (AbfB) and α-d-glucuronidase (AguA) enzymes were applied for side group removal, to increase adsorption of xylan from sugarcane (Saccharum officinarum L) bagasse (BH), bamboo (Bambusa balcooa) (BM), Pinus patula (PP) and Eucalyptus grandis (EH) onto cotton lint. The AguA treatment increased the adsorption of all xylans by up to 334%, whereas, the AbfB increased the adsorption of the BM and PP by 31% and 44%, respectively. A combination of AguA and AbfB treatment increased the adsorption, but to a lesser extent than achieved with AguA treatment. This indicated that the removal of the glucuronic acid side groups provided the most significant increase in xylan adsorption to cellulose, in particular through enzymatic treatment. Copyright © 2016 Elsevier Ltd. All rights reserved.

An Incremental, Measurable Approach to Increased Seismic Safety in Latin America and the Caribbean

Science.gov (United States)

Dickey, J. S.

2001-05-01

Plans for a multiyear effort to assess and mitigate seismic risks in municipalities throughout Latin America and the Caribbean are being developed by a committee of scientists, engineers and public servants from throughout the region. Prompted by AGU and GeoHazards International, with start-up funding from the AGU Council through the AGU Committee on International Participation, the effort will involve scientists, engineers, architects, urban planners, civil defense authorities, municipal authorities, public health authorities, and commerical interests. With technical guidance provided by the project, teams of volunteers will assess risks in their own municipalities and will identify and adopt measures to reduce those risks. Planned by Latin Americans for the benefit of Latin America, the process, which is intended to run for a ten year period, will be iterative and incremental. Progress will be measurable and will be reported at triennial conferences. As an international organization, well-represented in the region and unencumbered by political or commercial relationships, AGU is able to provide effective administrative support for this challenging endeavor.

Speaking Up For Science

Science.gov (United States)

Spilhaus, Fred

2005-06-01

The Smithsonian Institution's National Museum of Natural History in Washington D.C. is planning to show a film, "A Privileged Planet" that promotes creationism in the form of "intelligent design." The film is based on the book by Guillermo Gonzalez and Jay Wesley Richards, both affiliated with the Discovery Institute, which advocates teaching "intelligent design" as science in U.S. public schools. By associating with the Discovery Institute, the Smithsonian Institution will associate science with creationism and damage their credibility. The film is slated for airing on 23 June, unless the Smithsonian comes to its senses.Why is this important? Because the film promotes a long term strategy of the Discovery Institute (//www.discovery.org/csc/) to replace "materialistic science" with "intelligent design." The film fosters the idea that science should include the supernatural. This is unacceptable. AGU's position is clear, creationism is not science and AGU opposes all efforts to promote creationism as science, (The full text of the AGU position statement can be found at: //www.agu.org/sci_soc/policy/positions/evolution.shtml).

Students fall for Fall Meeting

Science.gov (United States)

Smedley, Kara

2012-02-01

From Boston to Beijing, thousands of students traveled to San Francisco for the 2011 AGU Fall Meeting. Of those who participated, 183 students were able to attend thanks to AGU's student travel grant program, which assists students with travel costs and seeks to enrich the meeting through ethnic and gender diversity. Students at Fall Meeting enjoyed a variety of programs and activities designed to help them better network with their peers, learn about new fields, and disseminate their research to the interested public. More than 800 students attended AGU's first annual student mixer, sharing drinks and ideas with fellow student members and future colleagues as well as forging new friendships and intellectual relationships.

Eliminating the OUCH in OUtreaCH

Science.gov (United States)

Karsten, J. L.; Manduca, C. A.

2004-12-01

``I'm a scientist who knows how to conduct research, not an expert in teaching pre-college students!'' is a common complaint within the scientific community in response to recent funding agency mandates that research proposals explicitly address education, public outreach or other broader impacts. Yet, these new requirements address several important goals - fostering public support for research funding in the Earth and Space sciences, recruiting the next generation of talented geoscientists in the face of declining student enrollments, and educating the citizenry for informed decision making and advocacy, chief among them. Further, the phrase ``broader impacts'' is not meant to be synonymous with outreach to pre-college students and teachers - agency program managers actually encourage many different types of activity for meeting these obligations. AGU and its Committee on Education and Human Resources (CEHR) are committed to offering an array of programs that facilitate our members' ability to meet these new education, outreach, and broader impacts criteria in support of the research enterprise. CEHR has an on-going need for scientists willing to speak about their research in Geophysical Information for Teacher (GIFT) Workshops, sponsored lectures at annual and regional conventions of the National Science Teachers Association, special symposia for minority high school students attending annual AGU meetings, and career planning workshops for students and early career investigators. More extensive involvement as meeting mentors for minority undergraduate and graduate students is available through AGU's partnership with the new MSPHDS initiative (A. Pyrtle, P.I.). A new AGU outreach web site now under development will make available scientist biographies and abstracts derived from recent scientific articles originally published in AGU journals, which have been rewritten for a public audience. This resource is expected to serve as an important vehicle for AGU members

Motor neuron disease: the impact of decreased speech intelligibility ...

African Journals Online (AJOL)

Background: The onset of motor neuron disease (MND), a neurodegenerative disease, results in physical and communication disabilities that impinge on an individual's ability to remain functionally independent. Multiple aspects of the marital relationship are affected by the continuously changing roles and responsibilities.

Handwriting, visuomotor integration, and neurological condition at school age

NARCIS (Netherlands)

van Hoorn, Jessika F.; Maathuis, Carel G. B.; Peters, Lieke H. J.; Hadders-Algra, Mijna

2010-01-01

Aim The study investigated the relationships between handwriting, visuomotor integration, and neurological condition. We paid particular attention to the presence of minor neurological dysfunction (MND). Method Participants were 200 children (131 males, 69 females; age range 8-13y) of whom 118

Test-retest, inter-assessor and intra-assessor reliability of the modified Touwen examination

NARCIS (Netherlands)

Peters, Lieke H. J.; Maathuis, Karel G. B.; Kouw, Eva; Hamming, Marjolein; Hadders-Algra, Mijna

Interest in the Touwen examination (1979) for the assessment of minor neurological dysfunction (MND) is growing. However, information on psychometric properties of this assessment is scarce. Therefore the present study aimed at assessing the test's test-retest, inter- and intra-assessor reliability.

An agmatine-inducible system for the expression of recombinant proteins in Enterococcus faecalis.

Science.gov (United States)

Linares, Daniel M; Perez, Marta; Ladero, Victor; Del Rio, Beatriz; Redruello, Begoña; Martin, M Cruz; Fernandez, María; Alvarez, Miguel A

2014-12-04

Scientific interest in Enterococcus faecalis has increased greatly over recent decades. Some strains are involved in food fermentation and offer health benefits, whereas others are vancomycin-resistant and cause infections that are difficult to treat. The limited availability of vectors able to express cloned genes efficiently in E. faecalis has hindered biotechnological studies on the bacterium's regulatory and pathogenicity-related genes. The agmatine deiminase (AGDI) pathway of E. faecalis, involved in the conversion of agmatine into putrescine, is driven by a response inducer gene aguR. This study describes that the exposure to the induction factor (agmatine) results in the transcription of genes under the control of the aguB promoter, including the aguBDAC operon. A novel E. faecalis expression vector, named pAGEnt, combining the aguR inducer gene and the aguB promoter followed by a cloning site and a stop codon was constructed. pAGEnt was designed for the overexpression and purification of a protein fused to a 10-amino-acid His-tag at the C-terminus. The use of GFP as a reporter of gene expression in E. faecalis revealed that under induction with 60 mM agmatine, fluorescence reached 40 arbitrary units compared to 0 in uninduced cells. pAGEnt vector can be used for the overexpression of recombinant proteins under the induction of agmatine in E. faecalis, with a close correlation between agmatine concentration and fluorescence when GFP was used as reporter.

Sequencing and Transcriptional Analysis of the Biosynthesis Gene Cluster of Putrescine-Producing Lactococcus lactis ▿ †

Science.gov (United States)

Ladero, Victor; Rattray, Fergal P.; Mayo, Baltasar; Martín, María Cruz; Fernández, María; Alvarez, Miguel A.

2011-01-01

Lactococcus lactis is a prokaryotic microorganism with great importance as a culture starter and has become the model species among the lactic acid bacteria. The long and safe history of use of L. lactis in dairy fermentations has resulted in the classification of this species as GRAS (General Regarded As Safe) or QPS (Qualified Presumption of Safety). However, our group has identified several strains of L. lactis subsp. lactis and L. lactis subsp. cremoris that are able to produce putrescine from agmatine via the agmatine deiminase (AGDI) pathway. Putrescine is a biogenic amine that confers undesirable flavor characteristics and may even have toxic effects. The AGDI cluster of L. lactis is composed of a putative regulatory gene, aguR, followed by the genes (aguB, aguD, aguA, and aguC) encoding the catabolic enzymes. These genes are transcribed as an operon that is induced in the presence of agmatine. In some strains, an insertion (IS) element interrupts the transcription of the cluster, which results in a non-putrescine-producing phenotype. Based on this knowledge, a PCR-based test was developed in order to differentiate nonproducing L. lactis strains from those with a functional AGDI cluster. The analysis of the AGDI cluster and their flanking regions revealed that the capacity to produce putrescine via the AGDI pathway could be a specific characteristic that was lost during the adaptation to the milk environment by a process of reductive genome evolution. PMID:21803900

Earth in Space: A CD-ROM Version for Pre-College Teachers

Science.gov (United States)

Pedigo, P.

2003-12-01

Earth in Space, a magazine about the Earth and space sciences for pre-college science teachers, was published by AGU between 1987 and 2001 (9 issues each year). The goal of Earth in Space was to make research at the frontiers of the geosciences accessible to teachers and students and engage them in thinking about scientific careers. Each issue contained two or three recent research articles, rewritten for a high school level audience from the original version published in peer-reviewed AGU journals, which were supplemented with short news items and biographic information about the authors. As part of a 2003 summer internship with AGU, sponsored by the AGU Committee on Education and Human Resources (CEHR) and the American Institute of Physics, this collection of Earth in Space magazines was converted into an easily accessible electronic resource for K-12 teachers and students. Every issue was scanned into a PDF file. The entire collection of articles was cataloged in a database indexed to key topic terms (e.g., volcanoes, global climate change, space weather). A front-page was designed in order to facilitate rapid access to articles concerning specific topics within the Earth and space sciences of particular interest to high school students. A compact CD-ROM version of this resource will be distributed to science teachers at future meetings of the National Science Teachers Association and will be made available through AGU's Outreach and Research Support program.

Clinical profile of motor neuron disease patients with lower urinary tract symptoms and neurogenic bladder.

Science.gov (United States)

Vázquez-Costa, Juan Francisco; Arlandis, Salvador; Hervas, David; Martínez-Cuenca, Esther; Cardona, Fernando; Pérez-Tur, Jordi; Broseta, Enrique; Sevilla, Teresa

2017-07-15

Lower urinary tract symptoms (LUTS) are frequent in motor neuron disease (MND) patients, but clinical factors related to them are unknown. We describe differences in LUTS among MND phenotypes and their relationship with other clinical characteristics, including prognosis. For this study, we collected clinical data of a previously published cohort of patients diagnosed with classical amyotrophic lateral sclerosis (cALS), progressive muscular atrophy (PMA) or primary lateral sclerosis (PLS) with and without LUTS. Familial history was recorded and the C9ORF72 expansion was analysed in the entire cohort. Patients were followed-up for survival until August 2016. Fifty-five ALS patients (37 cALS, 10 PMA and 8 PLS) were recruited. Twenty-four reported LUTS and neurogenic bladder (NB) could be demonstrated in nine of them. LUTS were not influenced by age, phenotype, disability, cognitive or behavioural impairment, or disease progression, but female sex appeared to be a protective factor (OR=0.39, p=0.06). Neither family history nor the C9ORF72 expansion was linked to LUTS or NB. In the multivariate analysis, patients reporting LUTS early in the disease course tended to show poorer survival. In this study, LUTS appear to be more frequent in male MND patients, but are not related to age, clinical or genetic characteristics. When reported early, LUTS could be a sign of rapid disease spread and poor prognosis. Further prospective longitudinal and neuroimaging studies are warranted to confirm this hypothesis. Copyright © 2017 Elsevier B.V. All rights reserved.

Studies on motor neuron disease with cranial magnetic resonance imaging

Energy Technology Data Exchange (ETDEWEB)

Mitsui, Yoshiyuki; Takahashi, Mitsuo; Nakamura, Yusaku; Kitaguchi, Masataka; Yagi, Yuji (Kinki Univ., Osaka (Japan). School of Medicine)

1992-05-01

The present study was performed to examine the pyramidal tracts of the brain in both 51 normal subjects (21 male and 30 female subjects; mean age of 43.5[+-]16.1 years) and 12 patients with motor neuron disease (6 male and 6 female patients; mean age of 57.4[+-]7.9 years), using the magnetic resonance imaging (MRI). The 12 patients with motor neuron disease (MND) comprised 7 suffering from spinal progressive muscular atrophy (SPMA) and 5 from amyotrophic lateral sclerosis (ALS). The MRI used in this study was of both short spin echo and long spin echo sequence. Of the 52 normal subjects, 24 of them (47%) had the T2 prolonged small areas (high signal intensity areas) at the posterior limb of internal capsule. These findings were not found in the normal subjects over fifty years old. No similar finding was detected in the pyramidal tracts except the posterior limb of internal capsule. On the other hand, 8 patients with MND (67%) proved to have the high signal intensity areas in the pyramidal tracts. Moreover, these high intensity areas were extended from the crus cerebri to corona radiata in 7 patients (58%). In all patients with ALS, these areas were extended in whole areas of the pyramidal tracts, and the similar findings were also found in two patients with SPMA. These findings were demonstrated to be more extensive than those in the normal subjects. The results thus obtained warrant us to conclude that cranial MRI is useful to detect the degeneration of the pyramidal tracts of MND patients. (author).

CSF glial markers correlate with survival in amyotrophic lateral sclerosis.

Science.gov (United States)

Süssmuth, S D; Sperfeld, A D; Hinz, A; Brettschneider, J; Endruhn, S; Ludolph, A C; Tumani, H

2010-03-23

In neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), CSF biomarkers are increasingly studied to evaluate their relevance for differential diagnosis, disease progression, and understanding of pathophysiologic processes. To identify a biomarker profile of neuronal and glial CSF proteins to discriminate ALS from other motor neuron diseases (MND) and to assess whether baseline levels of CSF measures in ALS are associated with the course of the disease. A total of 122 consecutive subjects with MND were included in this cross-sectional study (ALS, n = 75; lower motor neuron syndrome, n = 39; upper motor neuron diseases, n = 8). Clinical follow-up included 76 patients. We determined baseline levels of protein tau and astroglial S100beta in CSF and microglial sCD14 in CSF and serum in relation to diagnosis, duration of disease, and survival. CSF tau was significantly elevated in ALS and upper motor neuron diseases as compared to lower motor neuron diseases and controls. CSF S100beta levels were significantly lower in lower motor neuron diseases as compared to other MND. CSF concentrations of S100beta and sCD14 correlated with the survival time in patients with ALS. In motor neuron diseases, CSF tau elevation indicates the degeneration of upper motor neurons, while S100 beta and sCD14 may indicate the activation of CNS glial cells. Because S100beta and sCD14 concentrations correlate with survival in amyotrophic lateral sclerosis (ALS), we suppose that the combination of both markers may be useful to obtain prognostic information in patients with ALS.

Kunsti estica Rootsis ja Lätis

Index Scriptorium Estoniae

1999-01-01

Suvel hakkas Stockholmis ilmuma uus Põhjamaade kunstiajakiri "Nu", mis loodi Soome ajakirja "Siksi" ja Rootsi ajakirja "Index" ühendamisel. "NU" teises numbris "Nu" Eesti korrespondendi Harry Liivranna lühiartikkel Udo Siiast. Läti kunstiajakirjas Studija nr. 8 tutvustab Daiga Rudzate Veneetsia biennaaliga seoses Eesti ekspositsiooni, Irena Buzinska Tallinnas novembris avatavat inglise moefoto näitust. Läti kunstiajakirjas Acoustic.Space nr. 2 on Raivo Kelomehe informatsioon novembris Tallinnas toimuvast 2. meediakunsti festivalist ning Hanno Soansi videoprojekti tutvustus

Quality of general movements and the development of minor neurological dysfunction at toddler and school age

NARCIS (Netherlands)

Hadders-Algra, M; Mavinkurve-Groothuis, AMC; Stremmelaar, EF; Martijn, A; Butcher, PR; Groen, S.E

Objective: To evaluate the reliability of assessing infants' general movements (GMs) using a new classification and its validity in predicting complex minor neurological dysfunction (MND) at toddler and at school age. Design: Prospective study of two groups of infants, each consisting of a mix of

TDP-43 in Familial and Sporadic Frontotemporal Lobar Degeneration with Ubiquitin Inclusions

NARCIS (Netherlands)

Cairns, Nigel J.; Neumann, Manuela; Bigio, Eileen H.; Holm, Ida E.; Troost, Dirk; Hatanpaa, Kimmo J.; Foong, Chan; White, Charles L.; Schneider, Julie A.; Kretzschmar, Hans A.; Carter, Deborah; Taylor-Reinwald, Lisa; Paulsmeyer, Katherine; Strider, Jeffrey; Gitcho, Michael; Goate, Alison M.; Morris, John C.; Mishrall, Manjari; Kwong, Linda K.; Stieber, Anna; Xu, Yan; Forman, Mark S.; Trojanowski, John Q.; Lee, Virginia M.-Y.; Mackenzie, Ian R. A.

2007-01-01

TAR DNA-binding protein 43 (TDP-43) is a major pathological protein of sporadic and familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions (FTLD-U) with or without motor neuron disease (MND). Thus, TDP-43 defines a novel class of neurodegenerative diseases called

Risk factors for motor neuron diseases : genes, environment and lifestyle

NARCIS (Netherlands)

Sutedja, N.A.

2010-01-01

The main focus of this thesis is to identify susceptibility factors in diseases affecting the motor neuron: both motor neuron disease (MND), in which primarily the cell body is affected, and multifocal motor neuropathy (MMN), in which primarily the axon is affected, are covered. Due to its

Rare genetic variation in UNC13A may modify survival in amyotrophic lateral sclerosis

NARCIS (Netherlands)

Gaastra, Benjamin; Shatunov, Aleksey; Pulit, Sara; Jones, Ashley R; Sproviero, William; Gillett, Alexandra; Chen, Zhongbo; Kirby, Janine; Fogh, Isabella; Powell, John F; Leigh, P Nigel; Morrison, Karen E; Shaw, Pamela J; Shaw, Christopher E; van den Berg, Leonard H; Veldink, Jan H; Lewis, Cathryn M; Al-Chalabi, Ammar

2016-01-01

Our objective was to identify whether rare genetic variation in amyotrophic lateral sclerosis (ALS) candidate survival genes modifies ALS survival. Candidate genes were selected based on evidence for modifying ALS survival. Each tail of the extreme 1.5% of survival was selected from the UK MND DNA

The Genetics of Monogenic Frontotemporal Dementia

Directory of Open Access Journals (Sweden)

Leonel T. Takada

Full Text Available ABSTRACTAround 10-15% of patients diagnosed with frontotemporal dementia (FTD have a positive family history for FTD with an autosomal dominant pattern of inheritance. Since the identification of mutations in MAPT(microtubuleassociated protein tau gene in 1998, over 10 other genes have been associated with FTD spectrum disorders, discussed in this review. Along with MAPT, mutations in GRN(progranulin and C9orf72(chromosome 9 open reading frame 72 are the most commonly identified in FTD cohorts. The association of FTD and motor neuron disease (MND can be caused by mutations in C9orf72and other genes, such as TARDBP(TAR DNA-binding protein, FUS(fused in sarcoma, UBQLN2(ubiquilin 2. Multisystem proteinopathy is a complex phenotype that includes FTD, Paget disease of the bone, inclusion body myopathy and MND, and can be due to mutations in VCP(valosing containing protein and other recently identified genes.

Design and implementation of a hybrid MPI-CUDA model for the Smith-Waterman algorithm.

Science.gov (United States)

Khaled, Heba; Faheem, Hossam El Deen Mostafa; El Gohary, Rania

2015-01-01

This paper provides a novel hybrid model for solving the multiple pair-wise sequence alignment problem combining message passing interface and CUDA, the parallel computing platform and programming model invented by NVIDIA. The proposed model targets homogeneous cluster nodes equipped with similar Graphical Processing Unit (GPU) cards. The model consists of the Master Node Dispatcher (MND) and the Worker GPU Nodes (WGN). The MND distributes the workload among the cluster working nodes and then aggregates the results. The WGN performs the multiple pair-wise sequence alignments using the Smith-Waterman algorithm. We also propose a modified implementation to the Smith-Waterman algorithm based on computing the alignment matrices row-wise. The experimental results demonstrate a considerable reduction in the running time by increasing the number of the working GPU nodes. The proposed model achieved a performance of about 12 Giga cell updates per second when we tested against the SWISS-PROT protein knowledge base running on four nodes.

Candidates for office 2004-2006

Science.gov (United States)

Timothy L. Killeen. AGU member since 1981. Director of the National Center for Atmospheric Research (NCAR); Senior Scientist, High Altitude Observatory; Adjunct Professor, University of Michigan. Major areas of interest include space physics and aeronomy remote sensing, and interdisciplinary science education. B.S., Physics and Astronomy (first class honors), 1972, University College London; Ph.D., Atomic and Molecular Physics, 1975, University College London. University of Michigan: Researcher and Professor of Atmospheric, Oceanic, and Space Sciences, 1978-2000 Director of the Space Physics Research Laboratory 1993-1998 Associate Vice-President for Research, 1997-2000. Visiting senior scientist at NASA Goddard Space Flight Center, 1992. Program Committee, American Association for the Advancement of Science; Council Member, American Meteorological Society; Editor-in-Chief, Journal of Atmospheric and Solar-Terrestrial Physics; Chair, Jerome K.Weisner National Policy Symposium on the Integration of Research and Education, 1999. Authored over 140 publications, 57 in AGU journals. Significant publications include: Interaction of low energy positrons with gaseous atoms and molecules, Atomic Physics, 4, 1975; Energetics and dynamics of the thermosphere, Reviews of Geophysics, 1987; The upper mesosphere and lower thermosphere, AGU Geophysical Monograph, 1995, Excellence in Teaching and Research awards, College of Engineering, University of Michigan; recipient of two NASA Achievement Awards; former chair, NASA Space Physics Subcommittee; former chair, National Science Foundation (NSF) Coupling, Energetics and Dynamics of Atmospheric Regions (CEDAR) program; former member, NSF Advisory Committee for Geosciences, and chair of NSF's Atmospheric Sciences Subcommittee, 1999-2002 member, NASA Earth Science Enterprise Advisory Committee; member of various National Academy of Science/National Research Council Committees; cochair, American Association for the Advancement of Science

Anonymous Boh avatud kunsti maastikul / Raivo Kelomees

Index Scriptorium Estoniae

Kelomees, Raivo, 1960-

2010-01-01

Anonymous Bohi näitus Tartu Kunstimajas, avatud 30. juulini 2010. Anonymous Boh on koos Non Grataga läbi viinud performance´id Euroopas, Ameerikas ja Aasias. Anonymous Bohi vastused oma näituse ja loominguga seotud küsimustele

Baidu.com ajas investorid hulluks / Raivo Sormunen

Index Scriptorium Estoniae

Sormunen, Raivo, 1976-

2005-01-01

Maailma kasutatavuse poolest kuuenda Hiina Interneti otsingumootori aktsia tõusis kohe peale avalikku esmaemissiooni päevaga 354%, mis on suurim hinnatõus mitte-USA aktsiate hulgas läbi ajaloo. Diagramm: Baidu.com aktsia meeletus kõikumises. Lisa: Baidu.com - väike hiiglasuur ettevõte. Vt. samas: Baidu on ülisuure riski otsijale

Hea tulemuseni viib mitu teed / Raivo Juurak

Index Scriptorium Estoniae

Juurak, Raivo, 1949-

2014-01-01

28. veebruaril käivitatud 4 riiki haaravas ja 10 kuud kestvas koolijuhtide täiendusõppeprogrammis "Tuleviku kool" osalevad Hogeschool van Amsterdam Hollandist, Pädagogische Hochschule Zürichist, Schulamt Fürstentum Liechtensteinist ning Tallinna Ülikool Eestist. Hariduskorraldusest Hollandis räägib Education4Future Hollandi juht Marco Snoek, mõttevahetuses osalesid ka programmi Eesti juht Klemen Slabina ja TLÜ professor Mati Heidmets

Digitaalne kood kui materia prima / Raivo Kelomees

Index Scriptorium Estoniae

Kelomees, Raivo, 1960-

2003-01-01

Festival "Ars Electronica 2003" Austrias Linzis 6.-11. IX oli pühendatud koodile: seaduse-, kunsti-, bioloogilise ja arvutikoodi tähenduses. Tarkvarakunstiteemalisest (software art) diskussioonist. Peapreemia Goldene Nica - Blast Theory "Can you see me now?"

Viis kandidaati ühele õpetajakohale / Raivo Juurak

Index Scriptorium Estoniae

Juurak, Raivo

2007-01-01

Programmist "Noored kooli", etapi lõpuks selgitati välja 13 noort, kes lähevad tänavu 1. septembril kooli õpetajaks. Oma hinnangu programmile annavad üliõpilased: TTÜ geenitehnoloogiast P. Uuemaa, TTÜ logistikast K. Lillemets, EKA tekstiilidisainist I. Gross, TÜ inglise filoloogiast R. Kurg, TÜ hispaania keele ja politoloogia üliõpilane L. Prikk, TLÜ inglise filoloogiast T.-K. Kaber, TÜ eesti keel vene koolis erialalt N. Reppo, TTÜ geenitehnoloogiast P. Ahte ja TÜ inglise filoloogiast H. Haljaste

Ulukiliha sobib ka jõululauale / Raivo Feldmann

Index Scriptorium Estoniae

Feldmann, Raivo

2009-01-01

Adavere lihakauplusest, mida on külastanud ka president Toomas Hendrik Ilves ja proua Evelin Ilves. OÜ Chef Foodsi kaupa tellib ka presidendi kantselei. Juuresoleval fotol president Toomas Hendrik Ilves ja proua Evelin Ilves koos OÜ Chef Foodsi juhatuse liikme Veiko Villemi ja juhataja Priit Noorhaniga

"WRO 95" : meediakunsti festival Wroclawis / Raivo Kelomees

Index Scriptorium Estoniae

Kelomees, Raivo, 1960-

2007-01-01

5. rahvusvahelisest audiovisuaalse kunsti festivalist, millest võtsid osa Margus Tõnnov ja autor, seal toimunud Douglas Daviese, Astrid Sommeri, Erkki Huhtamo, Dieter Danielsi jt. loengutest, näitustest, videotest, feminismist, festivali tööde tasemest ja publikust. Ilmunud ka ajalehes "Eesti Ekspress", 1995, 16., 22., ja 30. juuni

Intel Corporation osaleb Eesti koolitusprogrammis / Raivo Juurak

Index Scriptorium Estoniae

Juurak, Raivo, 1949-

2001-01-01

Haridusministeeriumis tutvustati infotehnoloogiaalast koolitusprogrammi, milles osaleb maailma suuremaid arvutifirmasid Intel Corporation. Koolituskursuse käigus õpetatakse aineõpetajaid oma ainetundides interneti võimalusi kasutama. 50-tunnised kursused viiakse läbi kõigis maakondades

Helsingi saab eestlaste disainitud pingid / Raivo Murde

Index Scriptorium Estoniae

Murde, Raivo

2010-01-01

Eesti ettevõtte Frog Industrial Designi kaubamärgi Extery pingid "Klaar" võitsid Helsingi avaliku ruumi mööblikonkursi. Tooteseeria autoriteks on Martin Pärn, Edina Dufala-Pärn, Sven Sõrmus ja Pent Talvet disainibüroost Iseasi. Žürii valis Exteri toodangust välja ka teisi linnaruumis kasutatavaid elemente. Eestlaste disainitud linnamööbel on eksponeeritud Helsingi sisustusmessil Habitare

Igal pool ja mitte kuskil / Piibe Piirma

Index Scriptorium Estoniae

Piirma, Piibe

2006-01-01

Võrgu- ehk netikunsti ajaloost ja arengust. Korea kunstniku Nam June Paiki, Vene kunstnike Aleksei Shulgini ja Olja Ljalina, hollandi fotograafi Joan Heemskerk'i, belgia kunstniku Dirk Paesmans'i, sloveeni kunstnike Vuk Cosic'i ja Marko Pelijhan'i, kanada kunstniku Robert Adrian X-i, saksa kunstnike Wolfgang Staehle, Rena Tangens'i ja Cornelia Sollfranki tegevusest. Šveitsi kunstirühmituse "Etoy" performance'ist "Toywar". Lühidalt eesti võrgukunstist, Mare Tralla ja Tiia Johannsoni tegevusest. Repliigid Heie Treierilt ja Raivo Kelomehelt

E-kursuste konkursi tulemused / Reelyka Läheb

Index Scriptorium Estoniae

Läheb, Reelyka

2004-01-01

01.09.-31.10. 2003 toimus Tallinna Pedagoogikaülikoolis konkurss "Eesti e-Ülikooli toetus e-õppe kursustele, sügis 2003" eesmärgiga töötada välja uusi veebipõhiseid kursuseid. Konkursile laekunud 10 tööst otsustati ellu rakendada kõik. Projekti täitmiseks määrati toetused Hindrek Lootusele, Leif Kalevile, Anu Tootsile, Raivo Vetikule, Tiiu Reimole, Ivar Pornile, Sirje Pihtile, Kai Randrüütile ja Reelyka Lähebile

An Exploratory Study of Software Cost Estimating at the Electronic Systems Division.

Science.gov (United States)

1976-07-01

action’. to improve the software cost Sestimating proces., While thin research was limited to the M.nD onvironment, the same types of problema may exist...Methods in Social Science. Now York: Random House, 1969. 57. Smith, Ronald L. Structured Programming Series (Vol. XI) - Estimating Software Project

A Framework for Failure? The Impact of Short Tour Lengths and Separate National Command and Control on British Operational Art and Coalition Warfare in Iraq, 2003-2009

Science.gov (United States)

2013-12-10

frame the problem.54 This is a clear example of cognitive dissonance and highlights the intellectual confusion that had emerged in senior British...to explicitly express complete satisfaction with PJHQ and the command and control framework) came from LTG Riley, CG MND (SE) from Dec 04-Jun 05: LTG

Studies on motor neuron disease with cranial magnetic resonance imaging

International Nuclear Information System (INIS)

Mitsui, Yoshiyuki; Takahashi, Mitsuo; Nakamura, Yusaku; Kitaguchi, Masataka; Yagi, Yuji

1992-01-01

The present study was performed to examine the pyramidal tracts of the brain in both 51 normal subjects (21 male and 30 female subjects; mean age of 43.5±16.1 years) and 12 patients with motor neuron disease (6 male and 6 female patients; mean age of 57.4±7.9 years), using the magnetic resonance imaging (MRI). The 12 patients with motor neuron disease (MND) comprised 7 suffering from spinal progressive muscular atrophy (SPMA) and 5 from amyotrophic lateral sclerosis (ALS). The MRI used in this study was of both short spin echo and long spin echo sequence. Of the 52 normal subjects, 24 of them (47%) had the T2 prolonged small areas (high signal intensity areas) at the posterior limb of internal capsule. These findings were not found in the normal subjects over fifty years old. No similar finding was detected in the pyramidal tracts except the posterior limb of internal capsule. On the other hand, 8 patients with MND (67%) proved to have the high signal intensity areas in the pyramidal tracts. Moreover, these high intensity areas were extended from the crus cerebri to corona radiata in 7 patients (58%). In all patients with ALS, these areas were extended in whole areas of the pyramidal tracts, and the similar findings were also found in two patients with SPMA. These findings were demonstrated to be more extensive than those in the normal subjects. The results thus obtained warrant us to conclude that cranial MRI is useful to detect the degeneration of the pyramidal tracts of MND patients. (author)

Development of a Pseudomonas aeruginosa Agmatine Biosensor

OpenAIRE

Gilbertsen, Adam; Williams, Bryan

2014-01-01

Agmatine, decarboxylated arginine, is an important intermediary in polyamine production for many prokaryotes, but serves higher functions in eukaryotes such as nitric oxide inhibition and roles in neurotransmission. Pseudomonas aeruginosa relies on the arginine decarboxylase and agmatine deiminase pathways to convert arginine into putrescine. One of the two known agmatine deiminase operons, aguBA, contains an agmatine sensitive TetR promoter controlled by AguR. We have discovered that this pr...

Millimeter Wave Attenuation in Moist Air: Laboratory Measurements and Analysis.

Science.gov (United States)

1984-03-01

generation of incoherent noise, Mnd wavelengths. (e) scintillitions due to random fluctuations of the medium in space and time. The array of mathematical ...calculations are for observations in the zenith direction free air is very empty. The molecular radius r -1.5 x ICI-4 Lem. groud lvel Coaic aditio of

Author fees for online publication

Science.gov (United States)

Like the journals themselves, AGU publication fees have been restructured to accommodate the new online, publish-as-ready approach. The new fee structure is based on authors' providing electronic files of their text and art in acceptable formats (Word, WordPerfect, and LaTeX for text, and .eps or .tif for digital art). However, if you are unable to supply electronic files, you can opt for a higher-charge, full-service route in which AGU will create electronic files from hard copy. All authors for AGU journals are expected to support the journal archive through fees based on number as well as size of article files. The revenue from these fees is set aside for the "Perpetual Care Trust Fund," which will support the migration of the journal archive to new formats or media as technology changes. For several journals, excess length fees remain in place to encourage submission of concisely written articles. During this first transition year, most author fees are based on the number of print page equivalents (pdf) in an article; in the future, however, charges are expected to be associated with file size. The specific fees for each journal are posted on AGU's Web site under Publications-Tools for Authors.

Production of water-soluble sago waste - HAMPAS

International Nuclear Information System (INIS)

Norhazlin Zainuddin; Kamaruddin Hashim; Kamaruddin Bahari; Mansor Ahmad; Wan Md Zin Wan Yunus

2002-01-01

Carboxylmethyl sago waste (CMSW) was prepared in completely heterogeneous conditions as a product of the reaction of sago waste and sodium monochloroacetate (MCA) in mixed solution of isopropanol and sodium hydroxide (NaOH). The results showed that the DS values depend on the concentration of NaOH, ratio of MCA to anhydroglucose unit (AGU), (MCA:AGU), and also time and temperature of the reaction. DS value increased with increasing the concentration of NaOH and reaction temperature, but further increase will reduce the value of DS. Increasing the reaction time will increase the DS value and achieve a constant value after 2 hours. The study showed that the highest value of DS i.e. 1.04, could be achieved at 2:1 of MCA:AGU ratio, NaOh concentration of 25% and 2 hours reaction time at 55 degree C. (Author)

Arhitektuurieurovisiooni võitjad selgunud / Karin Hallas-Murula

Index Scriptorium Estoniae

Hallas, Karin, 1957-

2009-01-01

28. mail antakse Barcelonas üle 2009. a. Euroopa Liidu Mies van der Rohe nimelised kaasaegse arhitektuuri preemiad. Võitjaks tuli Oslo ooperi- ja balletiteater (arhitektuuribüroo Snohetta, arhitektid Kjetil Trædal Thorsen, Tarald Lundevall, Craig Dykers). Noore arhitekti eripreemia läks Horvaatia arhitektuuribüroole Studio Up (arhitektid Lea Pelivan, Toma Plejić) gümnaasiumi "46º09'N/16º50'E" eest Koprivnicas. Kataloogi valiti Eestist KOKO Arhitektide (Andrus Kõresaar, Raivo Kotov) projekteeritud Rotermanni kvartali laudsepatöökoja rekonstruktsioon

Jõulujazz alustab heaga / Kai Ilustrumm

Index Scriptorium Estoniae

Ilustrumm, Kai

2004-01-01

Heategevuskontserdist "Aita alustada elu!" Kaarli kirikus 28. nov., Soome multiinstrumentalisti Sakari Kukko trio kontserdist 5. dets. Niguliste muuseum-kontserdisaalis, ameerika vokaalansambli M-Pact kontserdist 7. dets. Pärnu kontserdimajas, Raivo Tafenau-Meelis Vindi koosmusitseerimisest tšiili löökpillimängija Ricardo Padillaga 11. dets. Niguliste muuseum-kontserisaalis, Helin-Mari Arderi kontserdist "Sajab esimest lund" 15. dets. Niguliste muuseum-kontserisaalis, rootsi ansambli Bossa Electrica esinemiset 16. dets. Rock Café's, ansambli Eesti Keeled kontserdist "Vaiksel ööl" 17. dets. Tallinnas Sokos Hotell Virus

Uued agulimajad = New Suburb Houses / Andri Ksenofontov

Index Scriptorium Estoniae

Ksenofontov, Andri, 1962-

2005-01-01

Tallinna ajalooliste eeslinnade teke ja kujunemine. Agulite olukord tänapäeval ja haldus viimastel aastatel. Büroo 3+1 projekteeritud ühepereelamu Magasini kvartalis (arhitektid Andres Ojari, Markus Kaasik, Ilmar Valdur, Merje Müürisepp, Kalle Komissarov). Neljakorruseline elamu Õle t. 23/Härjapea t. 14, ühtlasi arhitektide Madis Eegi ja Margit Mutso kodu. Gert Sarve projekteeritud kahepereelamu Herne t. 9. KOKO arhitektide Raivo Kotovi ja Tõnis Kimmeli projekteeritud korterelamu Vabriku t. 33. Ill.: 12 plaani, 14 värv. vaadet

Petition nominations for 1990-1992

Science.gov (United States)

The nominees listed below are those of the Union and section nominating committees and have been approved by the AGU Council.Nominations may also be made by membership petition. There are no age, nationality, residence or other analogous restrictions on who may serve as a n officer. Petitions should be sent to the General Secretary, AGU, 2000 Florida Avenue N.W., Washington, DC 20009. They must be received no later than July 7, 1989.

Amyotrophic lateral sclerosis presenting with orthopnea in a patient with COPD and obstructive sleep apnea

Directory of Open Access Journals (Sweden)

T.L.N. Swamy

2011-01-01

Full Text Available Amyotrophic lateral sclerosis (ALS, also known as motor neuron disease (MND is a relentlessly progressive neurological disorder causing peripheral muscular weakness and resultant respiratory failure. In this article, we report a case of ALS with chronic obstructive pulmonary disease (COPD and obstructive sleep apnea (OSA with orthopnea as initial symptoms.

Review of Indigenous Health Curriculum in Nutrition and Dietetics at One Australian University: An Action Research Study

Science.gov (United States)

Wilson, Annabelle M.; Mehta, Kaye; Miller, Jacqueline; Yaxley, Alison; Thomas, Jolene; Jackson, Kathryn; Wray, Amanda; Miller, Michelle D.

2015-01-01

This article describes a review undertaken in 2012-2013 by Nutrition and Dietetics, Flinders University, to assess the Indigenous health curriculum of the Bachelor of Nutrition and Dietetics (BND) and Masters of Nutrition and Dietetics (MND). An action research framework was used to guide and inform inquiry. This involved four stages, each of…

Mutant ApoA-1 Amyloidosis in a Family of Five Siblings With Motor Neuron Disease and Dementia

DEFF Research Database (Denmark)

Vrethema, Magnus; Mucchiano, Gerd Ingrid

2011-01-01

We present a family of fi ve siblings in which three brothers died of motor neuron disease (MND) and in two of them concomitant with dementia. A fourth brother died of myocardial infarction and was found to have extensive aortic intimal apolipoprotein A-1 (ApoA-1) derived amyloid deposits and apo...

Handwriting, Visuomotor Integration, and Neurological Condition at School Age

Science.gov (United States)

Van Hoorn, Jessika F.; Maathuis, Carel G. B.; Peters, Lieke H. J.; Hadders-Algra, Mijna

2010-01-01

Aim: The study investigated the relationships between handwriting, visuomotor integration, and neurological condition. We paid particular attention to the presence of minor neurological dysfunction (MND). Method : Participants were 200 children (131 males, 69 females; age range 8-13y) of whom 118 received mainstream education (mean age 10y 5mo, SD…

Transition from the adiabatic to the sudden limit in core-electron photoemission

Science.gov (United States)

Hedin, Lars; Michiels, John; Inglesfield, John

1998-12-01

Experimental results for core-electron photoemission Jk(ω) are often compared with the one-electron spectral function Ac(ɛk-ω), where ω is the photon energy, ɛk is the photoelectron energy, and the optical transition matrix elements are taken as constant. Since Jk(ω) is nonzero only for ɛk>0, we must actually compare it with Ac(ɛk-ω)θ(ɛk). For metals Ac(ω) is known to have a quasiparticle (QP) peak with an asymmetric power-law [theories of Mahan, Nozières, de Dominicis, Langreth, and others (MND)] singularity due to low-energy particle-hole excitations. The QP peak starts at the core-electron energy ɛc, and is followed by an extended satellite (shakeup) structure at smaller ω. For photon energies ω just above threshold, ωth=-ɛc, Ac(ɛk-ω)θ(ɛk) as a function of ɛk (ω constant) is cut just behind the quasiparticle peak, and neither the tail of the MND line nor the plasmon satellites are present. The sudden (high-energy) limit is given by a convolution of Ac(ω) and a loss function, i.e., by the Berglund-Spicer two-step expression. Thus Ac(ω) alone does not give the correct photoelectron spectrum, neither at low nor at high energies. We present an extension of the quantum-mechanical (QM) models developed earlier by Inglesfield, and by Bardyszewski and Hedin to calculate Jk(ω). It includes recoil and damping, as well as shakeup effects and extrinsic losses, is exact in the high-energy limit, and allows calculations of Jk(ω) including the MND line and multiple plasmon losses. The model, which involves electrons coupled to quasibosons, is motivated by detailed arguments. As an illustration we have made quantitative calculations for a semi-infinite jellium with the density of aluminum metal and an embedded atom. The coupling functions (fluctuation potentials) between the electron and the quasibosons are related to the random-phase-approximation dielectric function, and different levels of approximations are evaluated numerically. The differences

President's message: We must remain committed to scientific integrity

Science.gov (United States)

McPhaden, Michael

2012-02-01

During the third week of February our global community of Earth and space scientists witnessed the shocking fall from grace of an accomplished AGU member who betrayed the principles of scientific integrity. In doing so he compromised AGU's credibility as a scientific society, weakened the public's trust in scientists, and produced fresh fuel for the unproductive and seemingly endless ideological firestorm surrounding the reality of the Earth's changing climate. Peter Gleick resigned as chair of AGU's Task Force on Scientific Ethics on 16 February, prior to admitting in a blog post that he obtained documents from the Heartland Institute under false pretenses. His transgression cannot be condoned, regardless of his motives. It is a tragedy that requires us to stop and reflect on what we value as scientists and how we want to be perceived by the public. Here are a few things that come immediately to mind:

Influence of extractable soil manganese on oxidation capacity of different soils in Korea

Science.gov (United States)

Chon, Chul-Min; Kim, Jae Gon; Lee, Gyoo Ho; Kim, Tack Hyun

2008-08-01

We examined the relationship between soil oxidation capacity and extractable soil manganese, iron oxides, and other soil properties. The Korean soils examined in this study exhibited low to medium Cr oxidation capacities, oxidizing 0.00-0.47 mmol/kg, except for TG-4 soils, which had the highest capacity for oxidizing added Cr(III) [>1.01 mmol/kg of oxidized Cr(VI)]. TG and US soils, with high Mn contents, had relatively high oxidation capacities. The Mn amounts extracted by dithionite-citrate-bicarbonate (DCB) (Mnd), NH2OH·HCl (Mnh), and hydroquinone (Mnr) were generally very similar, except for the YS1 soils, and were well correlated. Only small proportions of either total Mn or DCB-extractable Mn were extracted by NH2OH·HCl and hydroquinone in the YS1 soils, suggesting inclusion of NH2OH·HCl and hydroquinone-resistant Mn oxides, because these extractants are weaker reductants than DCB. No Cr oxidation test results were closely related to total Mn concentrations, but Mnd, Mnh, and Mnr showed a relatively high correlation with the Cr tests ( r = 0.655-0.851; P Mnh were better correlated with the Cr oxidation tests than was the Mnr concentration, suggesting that the oxidation capacity of our soil samples can be better explained by Mnd and Mnh than by Mnr. The first component in principal components analysis indicated that extractable soil Mn was a main factor controlling net Cr oxidation in the soils. Total soil Mn, Fe oxides, and the clay fraction are crucial for predicting the mobility of pollutants and heavy metals in soils. The second principal component indicated that the presence of Fe oxides in soils had a significant relationship with the clay fraction and total Mn oxide, and was also related to heavy-metal concentrations (Zn, Cd, and Cu, but not Pb).

Age-Related Uptake of Heavy Metals in Human Spinal Interneurons.

Directory of Open Access Journals (Sweden)

Roger Pamphlett

Full Text Available Toxic heavy metals have been implicated in the loss of spinal motoneurons in amyotrophic lateral sclerosis/motor neuron disease (ALS/MND. Motoneuron loss in the spinal anterior horn is severe in ALS/MND at the time of death, making this tissue unsuitable for examination. We therefore examined spinal cords of people without muscle weakness to look for any presence of heavy metals that could make these neurons susceptible to damage. Spinal cord samples from 50 individuals aged 1-95 y who had no clinical or histopathological evidence of spinal motoneuron loss were studied. Seven μm formalin-fixed paraffin-embedded sections were stained for heavy metals with silver nitrate autometallography (AMGHM which detects intracellular mercury, silver or bismuth. Neurons in the spinal cord were classified as interneurons or α-motoneurons based on their site and cell body diameter. Spinal interneurons containing heavy metals were present in 8 of 24 people (33% aged 61-95 y, but not at younger ages. These AMGHM interneurons were most numerous in the lumbar spinal cord, with moderate numbers in the caudal cervical cord, few in the rostral cervical cord, and almost none in the thoracic cord. All people with AMGHM interneurons had occasional AMGHM staining in α-motoneurons as well. In one man AMGHM staining was present in addition in dorsomedial nucleus and sensory neurons. In conclusion, heavy metals are present in many spinal interneurons, and in a few α-motoneurons, in a large proportion of older people. Damage to inhibitory interneurons from toxic metals in later life could result in excitotoxic injury to motoneurons and may underlie motoneuron injury or loss in conditions such as ALS/MND, multiple sclerosis, sarcopenia and calf fasciculations.

Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.

Science.gov (United States)

Baldauf, Hanna-Mari; Stegmann, Lena; Schwarz, Sarah-Marie; Ambiel, Ina; Trotard, Maud; Martin, Margarethe; Burggraf, Manja; Lenzi, Gina M; Lejk, Helena; Pan, Xiaoyu; Fregoso, Oliver I; Lim, Efrem S; Abraham, Libin; Nguyen, Laura A; Rutsch, Frank; König, Renate; Kim, Baek; Emerman, Michael; Fackler, Oliver T; Keppler, Oliver T

2017-03-07

Early after entry into monocytes, macrophages, dendritic cells, and resting CD4 T cells, HIV encounters a block, limiting reverse transcription (RT) of the incoming viral RNA genome. In this context, dNTP triphosphohydrolase SAM domain and HD domain-containing protein 1 (SAMHD1) has been identified as a restriction factor, lowering the concentration of dNTP substrates to limit RT. The accessory lentiviral protein X (Vpx) proteins from the major simian immunodeficiency virus of rhesus macaque, sooty mangabey, and HIV-2 (SIVsmm/SIVmac/HIV-2) lineage packaged into virions target SAMHD1 for proteasomal degradation, increase intracellular dNTP pools, and facilitate HIV cDNA synthesis. We find that virion-packaged Vpx proteins from a second SIV lineage, SIV of red-capped mangabeys or mandrills (SIVrcm/mnd-2), increased HIV infection in resting CD4 T cells, but not in macrophages, and, unexpectedly, acted in the absence of SAMHD1 degradation, dNTP pool elevation, or changes in SAMHD1 phosphorylation. Vpx rcm/mnd-2 virion incorporation resulted in a dramatic increase of HIV-1 RT intermediates and viral cDNA in infected resting CD4 T cells. These analyses also revealed a barrier limiting HIV-1 infection of resting CD4 T cells at the level of nuclear import. Single amino acid changes in the SAMHD1-degrading Vpx mac239 allowed it to enhance early postentry steps in a Vpx rcm/mnd-2-like fashion. Moreover, Vpx enhanced HIV-1 infection of SAMHD1-deficient resting CD4 T cells of a patient with Aicardi-Goutières syndrome. These results indicate that Vpx, in addition to SAMHD1, overcomes a previously unappreciated restriction for lentiviruses at the level of RT that acts independently of dNTP concentrations and is specific to resting CD4 T cells.

The Effects of Motor Neurone Disease on Language: Further Evidence

Science.gov (United States)

Bak, Thomas H.; Hodges, John R.

2004-01-01

It might sound surprising that Motor Neurone Disease (MND), regarded still by many as the very example of a neurodegenerative disease affecting selectively the motor system and sparing the sensory functions as well as cognition, can have a significant influence on language. In this article we hope to demonstrate that language dysfunction is not…

Synthèse: Revue des Sciences et de la Technologie - Vol 17 (2008)

African Journals Online (AJOL)

Modélisation numérique d'un phénomène mécanique (TRIP) induit par une transformation martensitique dans l'acier 16MND5 · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. S Mefta, L Taleb, F Barbe, F Sidoroff, 73-84 ...

Mechanical cough augmentation techniques in amyotrophic lateral sclerosis/motor neuron disease

OpenAIRE

Rafiq, M.K.; Bradburn, M.; Mustfa, N.; Mcdermott, C.J.; Annane, D.

2016-01-01

© 2016 The Cochrane Collaboration.This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects of mechanical insufflator/exsufflator (MI-E) and the breath-stacking technique for reducing morbidity and mortality and enhancing quality of life in people with amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND).

[History of hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P)].

Science.gov (United States)

Takashima, Hiroshi

2013-01-01

We established a new disease autosomal dominant hereditary motor and sensory neuropathy with proximal dominant involvement (HMSNP) in 1997, in Okinawa, Japan. This disease is characterized by proximal dominant neurogenic atrophy with fasciculations, painful muscle cramp, obvious sensory nerve involvement, areflexia, high incidence of elevated creatine kinase levels, hyperlipidemia and hyperglycemia. (MIM %604484). HMSNP is so called or HMSNO (HMSN OKINAWA type),. These clinical features resembled those of Kennedy-Alter-Sung syndrome. Most HMSNP patients have severe muscle atrophy and finally the tracheostomy and artificial ventilation are required. Therefore, we initially thought to classify HMSNP into a subtype of motor neuron disease (MND) like familial amyotrophic lateral sclerosis (FALS) or spinal muscular atrophy (SMA). However, the general consensus for MND was no sensory involvement. Therefore, as the disease showed severe sensory involvement, we categorized HMSNP in subtype of HMSN at that time. We also reported the pathology of HMSNP, showing severely decreased anterior horn cells, decreased posterior horn cells, and loss of posterior funiculus in the spinal cord.

Therapeutic opportunities and challenges of induced pluripotent stem cells-derived motor neurons for treatment of amyotrophic lateral sclerosis and motor neuron disease

Institute of Scientific and Technical Information of China (English)

Manoj Kumar Jaiswal

2017-01-01

Amyotrophic lateral sclerosis (ALS) and motor neuron diseases (MNDs) are progressive neurodegenera-tive diseases that affect nerve cells in the brain affecting upper and lower motor neurons (UMNs/LMNs), brain stem and spinal cord.The clinical phenotype is characterized by loss of motor neurons (MNs), mus-cular weakness and atrophy eventually leading to paralysis and death due to respiratory failure within 3–5 years after disease onset. No effective treatment or cure is currently available that halts or reverses ALS and MND except FDA approved drug riluzole that only modestly slows the progression of ALS in some patients. Recent advances in human derived induced pluripotent stem cells have made it possible for the first time to obtain substantial amounts of human cells to recapitulate in vitro"disease in dish"and test some of the underlying pathogenetic mechanisms involved in ALS and MNDs. In this review, I discussed the opportunities and challenges of induced pluropotent stem cells-derived motor neurons for treatment of ALS and MND patients with special emphasis on their implications in finding a cure for ALS and MNDs.

Therapeutic opportunities and challenges of induced pluripotent stem cells-derived motor neurons for treatment of amyotrophic lateral sclerosis and motor neuron disease.

Science.gov (United States)

Jaiswal, Manoj Kumar

2017-05-01

Amyotrophic lateral sclerosis (ALS) and motor neuron diseases (MNDs) are progressive neurodegenerative diseases that affect nerve cells in the brain affecting upper and lower motor neurons (UMNs/LMNs), brain stem and spinal cord. The clinical phenotype is characterized by loss of motor neurons (MNs), muscular weakness and atrophy eventually leading to paralysis and death due to respiratory failure within 3-5 years after disease onset. No effective treatment or cure is currently available that halts or reverses ALS and MND except FDA approved drug riluzole that only modestly slows the progression of ALS in some patients. Recent advances in human derived induced pluripotent stem cells have made it possible for the first time to obtain substantial amounts of human cells to recapitulate in vitro " disease in dish " and test some of the underlying pathogenetic mechanisms involved in ALS and MNDs. In this review, I discussed the opportunities and challenges of induced pluropotent stem cells-derived motor neurons for treatment of ALS and MND patients with special emphasis on their implications in finding a cure for ALS and MNDs.

200 rõõmsat presidenti / Inna Grünfeldt

Index Scriptorium Estoniae

Grünfeldt, Inna, 1961-

2009-01-01

Rakvere Galerii ja Soome Tuglase Seltsi koostöös korraldatud lastejoonistuste võistlusele "Presidendi pai" laekus ligi 200 Eesti presidendi Toomas Hendrik Ilvese ja Soome presidendi Tarja Haloneni portreed. Joonistuste paremik pannakse välja Soomes Helsingi Kaablitehases mardilaada raames avatavale näitusele. Seejärel läheb näitus rändama mööda Soome koole. 2010. a. kevadel, kui Eesti riigipea tuleb Lääne-Virumaale maakonnavisiidile, saab "Presidendi paid" näha Rakvere Galeriis. Joonistusvõistluse Eesti-poolsed korraldajad olid Raivo Riim ja Riho Hütt

Rupther: a simulation approach applied to a PWR vessel failure during a severe accident

International Nuclear Information System (INIS)

Mongabure, Ph.; Nicolas, L.; Devos, J.

2000-01-01

The Rupther program (Rupture Under Thermal Conditions) is a part of the international researches on severe accidents in the PWR type reactors. The aim of the program is the definition of failure simulation validated by experimental data on vessel steel 16MND5 mechanical properties. The paper presents the program and the first results. (A.L.B.)

Negotiating the Nation in History: the Swedish State Approval Scheme for Textbooks and Teaching Aids from 1945 to 1983

Science.gov (United States)

Elmersjö, Henrik Åström

2016-01-01

This article explores the discussions concerning history textbooks that occurred within the Swedish State Approval Scheme for Textbooks (Statens läroboksnämnd) from 1945 to 1983. By focusing on the negotiation of nationhood and the process of textbook approval as an arena for the renegotiation of ways in which history was taught in schools, the…