Calculs de doses générées par les rayonnements ionisants principes physiques et codes de calcul

CERN Document Server

Vivier, Alain

2016-01-01

Cet ouvrage et les codes associés s’adressent aux utilisateurs de sources de rayonnements ionisants : techniciens, ingénieurs de sécurité, personnes compétentes en radioprotection, mais aussi médecins, chercheurs, concepteurs, décideurs… Les contraintes croissantes liées à la radioprotection rendent indispensables l’utilisation de codes de calcul permettant d’évaluer les débits de doses générées par ces sources et la façon dont on peut s’en protéger au mieux. De nombreux codes existent, dont certains restent des références incontournables, mais ils sont relativement complexes à mettre en oeuvre et restent en général réservés aux bureaux d’études. En outre, ces codes sont souvent des « boîtes noires » qui ne permettent pas de comprendre la physique sous-jacente. L’objectif de cet ouvrage est double : - Exposer les principes physiques permettant de comprendre les phénomènes à l’oeuvre lorsque la matière est irradiée par des rayonnements ionisants. Il devient al...

A two dimensional code (R,Z) for nuclear reactor analysis and its application to the UAR-RI reactor

International Nuclear Information System (INIS)

Bishay, S.T.; Mikhail, I.F.I.; Gaafar, M.A.; Michaiel, M.L.; Nassar, S.F.

1988-01-01

A detailed study is given of fuel consumption in completely reflected cylindrical reactors. A two group, two dimensional (r,z) code is developed to carry out the required procedure. The code is applied to the UAR-RI reactor and the results are found to be in complete agreement with the experimental observations and with the theoretical interpretations. 7 fig., 12 tab

Thermal neutron flux distribution in the ET R R-1 reactor core as experimentally measured and theoretically calculated by the code triton

Energy Technology Data Exchange (ETDEWEB)

Imam, M [National center for nuclear safety and radiation control, atomic energy authority, Cairo, (Egypt)

1995-10-01

Thermal neutron flux distributions that were measured earlier at the ET-R R-1 reactor are compared with those calculated by the three dimensional diffusion code Triton. This comparison was made for the horizontal and vertical flux distributions. The horizontal thermal flux distributions considered in this comparison were along the core diagonals at two planes of different heights from core bottom, where one at a level passing through the control rod at core center and the other at a level below this control rod. In the meantime all the control rods were taken into consideration. The effect of the existence of a water cavity inside the core as well as the influence of the control rods on the thermal flux are illustrated in this work. The vertical thermal flux distributions considered in the comparison were at two positions in core namely; one along the core height the horizontal reactor power distribution along the core height and the horizontal reactor power distribution along the core diagonal as calculated by the code Triton are also given this work. 8 figs., 1 tab.

Defects in railway bridges and procedures for maintenance:UIC Code 778-4R

OpenAIRE

Elfgren, Lennart

2009-01-01

This leaflet gives guidelines and recommendations covering procedures for the maintenance and strengthening of railway bridges. Arrangements and methods for inspection are presented; defects are described; methods for monitoring and assessment are given; and procedures for maintenance, repair, strengthening and renewal are defined.The purpose is to update the 1989 edition of UIC Code 778-4R and to implement results from a European Integrated Research Project (2003-2007) on “Sustainable Bridge...

Transient cases analyses of the TRIGA IPR-R1 using thermal hydraulic and neutron kinetic coupled codes

Energy Technology Data Exchange (ETDEWEB)

Reis, Patricia A.L.; Costa, Antonella L.; Pereira, Claubia; Veloso, Maria A.F.; Scari, Maria E., E-mail: patricialire@yahoo.com.br, E-mail: antonella@nuclear.ufmg.br, E-mail: claubia@nuclear.ufmg.br, E-mail: dora@nuclear.ufmg.br, E-mail: melizabethscari@yahoo.com [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Departamento de Engenharia Nuclear; Instituto Nacional de Ciencias e Tecnologia de Reatores Nucleares Inovadores (INCT/CNPq), Belo Horizonte (Brazil); Miro, Rafael; Verdu, Gumersindo, E-mail: rmiro@iqn.upv.es, E-mail: gverdu@iqn.upv.es [Universidad Politecnica de Valencia (Spain). Departamento de Ingenieria Quimica y Nuclear

2015-07-01

Simulations and analyses of nuclear reactors have been improved by utilization of coupled thermal-hydraulic (TH) and neutron kinetics (NK) system codes especially to simulate transients that involve strong feedback effects between NK and TH. The TH-NK coupling technique was initially developed and used to simulate the behavior of power reactors; however, several coupling methodologies are now being applied for research reactors. This work presents the coupling methodology application between RELAP5 and PARCS codes using as a model the TRIGA IPR-R1 research reactor. Analyses of steady state and transient conditions and comparisons with results from simulations using only the RELAP5 code are being presented in this paper. (author)

An analytical demonstration of coupling schemes between magnetohydrodynamic codes and eddy current codes

International Nuclear Information System (INIS)

Liu Yueqiang; Albanese, R.; Rubinacci, G.; Portone, A.; Villone, F.

2008-01-01

In order to model a magnetohydrodynamic (MHD) instability that strongly couples to external conducting structures (walls and/or coils) in a fusion device, it is often necessary to combine a MHD code solving for the plasma response, with an eddy current code computing the fields and currents of conductors. We present a rigorous proof of the coupling schemes between these two types of codes. One of the coupling schemes has been introduced and implemented in the CARMA code [R. Albanese, Y. Q. Liu, A. Portone, G. Rubinacci, and F. Villone, IEEE Trans. Magn. 44, 1654 (2008); A. Portone, F. Villone, Y. Q. Liu, R. Albanese, and G. Rubinacci, Plasma Phys. Controlled Fusion 50, 085004 (2008)] that couples the MHD code MARS-F[Y. Q. Liu, A. Bondeson, C. M. Fransson, B. Lennartson, and C. Breitholtz, Phys. Plasmas 7, 3681 (2000)] and the eddy current code CARIDDI[R. Albanese and G. Rubinacci, Adv. Imaging Electron Phys. 102, 1 (1998)]. While the coupling schemes are described for a general toroidal geometry, we give the analytical proof for a cylindrical plasma.

Recent R and D around the Monte-Carlo code Tripoli-4 for criticality calculation

International Nuclear Information System (INIS)

Hugot, F.X.; Lee, Y.K.; Malvagi, F.

2008-01-01

TRIPOLI-4 [1] is the fourth generation of the TRIPOLI family of Monte Carlo codes developed from the 60's by CEA. It simulates the 3D transport of neutrons, photons, electrons and positrons as well as coupled neutron-photon propagation and electron-photons cascade showers. The code addresses radiation protection and shielding problems, as well as criticality and reactor physics problems through both critical and subcritical neutronics calculations. It uses full pointwise as well as multigroup cross-sections. The code has been validated through several hundred benchmarks as well as measurement campaigns. It is used as a reference tool by CEA as well as its industrial and institutional partners, and in the NURESIM [2] European project. Section 2 reviews its main features, with emphasis on the latest developments. Section 3 presents some recent R and D for criticality calculations. Fission matrix, Eigen-values and eigenvectors computations will be exposed. Corrections on the standard deviation estimator in the case of correlations between generation steps will be detailed. Section 4 presents some preliminary results obtained by the new mesh tally feature. The last section presents the interest of using XML format output files. (authors)

A Slater parameter optimisation interface for the CIV3 atomic structure code and its possible use with the R-matrix close coupling collision code

International Nuclear Information System (INIS)

Fawcett, B.C.; Hibbert, A.

1989-11-01

Details are here provided of amendments to the atomic structure code CIV3 which allow the optional adjustment of Slater parameters and average energies of configurations so that they result in improved energy levels and eigenvectors. It is also indicated how, in principle, the resultant improved eigenvectors can be utilised by the R-matrix collision code, thus providing an optimised target for close coupling collision strength calculations. An analogous computational method was recently reported for distorted wave collision strength calculations and applied to Fe XIII. The general method is suitable for the computation of collision strengths for complex ions and in some cases can then provide a basis for collision strength calculations in ions where ab initio computations break down or result in unnecessarily large errors. (author)

Atucha II NPP full scope simulator modelling with the thermal hydraulic code TRAC{sub R}T

Energy Technology Data Exchange (ETDEWEB)

Alonso, Pablo Rey; Ruiz, Jose Antonio; Rivero, Norberto, E-mail: prey@tecnatom.e, E-mail: jaruiz@tecnatom.e, E-mail: nrivero@tecnatom.e [Tecnatom S.A., Madrid (Spain)

2011-07-01

In February 2010 NA-SA (Nucleoelectrica Argentina S.A.) awarded Tecnatom the Atucha II full scope simulator project. NA-SA is a public company owner of the Argentinean nuclear power plants. Atucha II is due to enter in operation shortly. Atucha II NPP is a PHWR type plant cooled by the water of the Parana River and has the same design as the Atucha I unit, doubling its power capacity. Atucha II will produce 745 MWe utilizing heavy water as coolant and moderator, and natural uranium as fuel. A plant singular feature is the permanent core refueling. TRAC{sub R}T is the first real time thermal hydraulic six-equations code used in the training simulation industry for NSSS modeling. It is the result from adapting to real time the best estimate code TRACG. TRAC{sub R}T is based on first principle conservation equations for mass, energy and momentum for liquid and steam phases, with two phase flows under non homogeneous and non equilibrium conditions. At present, it has been successfully implemented in twelve full scope replica simulators in different training centers throughout the world. To ease the modeling task, TRAC{sub R}T includes a graphical pre-processing tool designed to optimize this process and alleviate the burden of entering alpha numerical data in an input file. (author)

Large Intergenic Non-coding RNA-RoR Inhibits Aerobic Glycolysis of Glioblastoma Cells via Akt Pathway

Science.gov (United States)

Li, Yong; He, Zhi-Cheng; Liu, Qing; Zhou, Kai; Shi, Yu; Yao, Xiao-Hong; Zhang, Xia; Kung, Hsiang-Fu; Ping, Yi-Fang; Bian, Xiu-Wu

2018-01-01

Reprogramming energy metabolism is a hallmark of malignant tumors, including glioblastoma (GBM). Aerobic glycolysis is often utilized by tumor cells to maintain survival and proliferation. However, the underlying mechanisms of aerobic glycolysis in GBM remain elusive. Herein, we demonstrated that large intergenic non-coding RNA-RoR (LincRNA-RoR) functioned as a critical suppressor to inhibit the aerobic glycolysis and viability of GBM cells. We found that LincRNA-RoR was markedly reduced in GBM tissues compared with adjacent non-tumor tissues from 10 cases of GBM patients. Consistently, LincRNA-RoR expression in GBM cells was significantly lower than that in normal glial cells. The aerobic glycolysis of GBM cells, as determined by the measurement of glucose uptake and lactate production, was impaired by LincRNA-RoR overexpression. Mechanistically, LincRNA-RoR inhibited the expression of Rictor, the key component of mTORC2 (mammalian target of rapamycin complex 2), to suppress the activity of Akt pathway and impair the expression of glycolytic effectors, including Glut1, HK2, PKM2 and LDHA. Finally, enforced expression of LincRNA-RoR reduced the proliferation of GBM cells in vitro, restrained tumor growth in vivo, and repressed the expression of glycolytic molecules in GBM xenografts. Collectively, our results underscore LincRNA-RoR as a new suppressor of GBM aerobic glycolysis with therapeutic potential. PMID:29581766

R and Matlab

CERN Document Server

Hiebeler, David E

2015-01-01

The First Book to Explain How a User of R or MATLAB Can Benefit from the OtherIn today's increasingly interdisciplinary world, R and MATLAB® users from different backgrounds must often work together and share code. R and MATLAB® is designed for users who already know R or MATLAB and now need to learn the other platform. The book makes the transition from one platform to the other as quick and painless as possible.Enables R and MATLAB Users to Easily Collaborate and Share CodeThe author covers essential tasks, such as working with matrices and vectors, writing functions and other programming co

Z₂-double cyclic codes

OpenAIRE

Borges, J.

2014-01-01

A binary linear code C is a Z2-double cyclic code if the set of coordinates can be partitioned into two subsets such that any cyclic shift of the coordinates of both subsets leaves invariant the code. These codes can be identified as submodules of the Z2[x]-module Z2[x]/(x^r − 1) × Z2[x]/(x^s − 1). We determine the structure of Z2-double cyclic codes giving the generator polynomials of these codes. The related polynomial representation of Z2-double cyclic codes and its duals, and the relation...

R134a Flow Boiling Analysis with Modified Thermodynamic Property File of MARS Code

Energy Technology Data Exchange (ETDEWEB)

Son, Gyumin; Bang, In Cheol [UNIST, Ulsan (Korea, Republic of)

2016-10-15

Previous study showed application of RELAP5 code to solar energy facility with molten salt (60% NaNO3 and 40% KNO3) as working fluid. Based on external experimental correlations, thermodynamic properties of molten salt were evaluated as a function of pressure and temperature and those equations were used to generate tpf. To validate external tpf, experimental values were compared with RELAP5 analysis. In nuclear field, utilization of other fluid is also important since many thermal-hydraulic experiments used various fluids such as FC-72, R123, and R134a. Theses refrigerants have been used to simulate the high pressure environment of nuclear power plants due to their low boiling point, and density ratio between vapor and liquid. Thus, this study aims for tpf generation of R134a and verification by analyzing real case. R134a is selected as a fluid to be implemented and analyzed because it is currently used in refrigerator and frequently used in flow boiling experiment related with heat transfer coefficient and CHF measurement. R134a property file were generated with fitted equation using temperature and pressure as variables, originated from external data source. For validation, flow boiling experiment case were made into simplified input. Analysis with tpfr134a showed that application of Gnielinksi correlation could enhance single phase flow accuracy. Large error of HTC from two phase analysis requires parameter study. Future work aims for more specified experimental case comparison and correlation enhancement for two phase analysis.

Hierarchical differences in population coding within auditory cortex.

Science.gov (United States)

Downer, Joshua D; Niwa, Mamiko; Sutter, Mitchell L

2017-08-01

Most models of auditory cortical (AC) population coding have focused on primary auditory cortex (A1). Thus our understanding of how neural coding for sounds progresses along the cortical hierarchy remains obscure. To illuminate this, we recorded from two AC fields: A1 and middle lateral belt (ML) of rhesus macaques. We presented amplitude-modulated (AM) noise during both passive listening and while the animals performed an AM detection task ("active" condition). In both fields, neurons exhibit monotonic AM-depth tuning, with A1 neurons mostly exhibiting increasing rate-depth functions and ML neurons approximately evenly distributed between increasing and decreasing functions. We measured noise correlation ( r noise ) between simultaneously recorded neurons and found that whereas engagement decreased average r noise in A1, engagement increased average r noise in ML. This finding surprised us, because attentive states are commonly reported to decrease average r noise We analyzed the effect of r noise on AM coding in both A1 and ML and found that whereas engagement-related shifts in r noise in A1 enhance AM coding, r noise shifts in ML have little effect. These results imply that the effect of r noise differs between sensory areas, based on the distribution of tuning properties among the neurons within each population. A possible explanation of this is that higher areas need to encode nonsensory variables (e.g., attention, choice, and motor preparation), which impart common noise, thus increasing r noise Therefore, the hierarchical emergence of r noise -robust population coding (e.g., as we observed in ML) enhances the ability of sensory cortex to integrate cognitive and sensory information without a loss of sensory fidelity. NEW & NOTEWORTHY Prevailing models of population coding of sensory information are based on a limited subset of neural structures. An important and under-explored question in neuroscience is how distinct areas of sensory cortex differ in their

Mirage, a food chain transfer and dosimetric impact code in relation with atmospheric and liquid dispersion codes

International Nuclear Information System (INIS)

Van Dorpe, F.; Jourdain, F.

2006-01-01

Full text: The numerical code M.I.R.A.G.E. (Module of Radiological impact calculations on the Environment due to accidental or chronic nuclear releases through Aqueous and Gas media) has been developed to simulate the radionuclides transfer in the biosphere and food chains, as well as the dosimetric impact on man, after accidental or chronic releases in the environment by nuclear installations. The originality of M.I.R.A.G.E. is to propose a single tool chained downstream with various atmospheric and liquid dispersion codes. The code M.I.R.A.G.E. is a series of modules which makes it possible to carry out evaluations on the transfers in food chains and human dose impact. Currently, M.I.R.A.G.E. is chained with a Gaussian atmospheric dispersion code H.A.R.M.A.T.T.A.N. (Cea), a 3 D atmospheric dispersion code with Lagrangian model named M.I.N.E.R.V.E.-S.P.R.A.Y. (Aria Technology) and a 3 D groundwater transfer code named M.A.R.T.H.E. (B.R.G.M.). M.I.R.A.G.E. uses concentration or activity result files as initial data input for its calculations. The application initially calculates the concentrations in the various compartments of the environment (soils, plants, animals). The results are given in the shape of concentration and dose maps and also on a particular place called a reference group for dosimetric impact (like a village or a specific population group located around a nuclear installation). The input and output data of M.I.R.A.G.E. can have geographic coordinates and thus readable by a G.I.S. M.I.R.A.G. E.is an opened system with which it is easy to chain other codes of dispersion that those currently used. The calculations uncoupled with dispersion calculations are also possible by manual seizure of the dispersion data (contamination of a tablecloth, particular value in a point, etc.). M.I.R.A.G.E. takes into account soil deposits and resuspension phenomenon, transfers in plants and animals (choice of agricultural parameters, types of plants and animals, etc

Constacyclic codes over the ring F_q+v{F}_q+v2F_q and their applications of constructing new non-binary quantum codes

Science.gov (United States)

Ma, Fanghui; Gao, Jian; Fu, Fang-Wei

2018-06-01

Let R={F}_q+v{F}_q+v2{F}_q be a finite non-chain ring, where q is an odd prime power and v^3=v. In this paper, we propose two methods of constructing quantum codes from (α +β v+γ v2)-constacyclic codes over R. The first one is obtained via the Gray map and the Calderbank-Shor-Steane construction from Euclidean dual-containing (α +β v+γ v2)-constacyclic codes over R. The second one is obtained via the Gray map and the Hermitian construction from Hermitian dual-containing (α +β v+γ v2)-constacyclic codes over R. As an application, some new non-binary quantum codes are obtained.

An Efficient Construction of Self-Dual Codes

OpenAIRE

Lee, Yoonjin; Kim, Jon-Lark

2012-01-01

We complete the building-up construction for self-dual codes by resolving the open cases over $GF(q)$ with $q \\equiv 3 \\pmod 4$, and over $\\Z_{p^m}$ and Galois rings $\\GR(p^m,r)$ with an odd prime $p$ satisfying $p \\equiv 3 \\pmod 4$ with $r$ odd. We also extend the building-up construction for self-dual codes to finite chain rings. Our building-up construction produces many new interesting self-dual codes. In particular, we construct 945 new extremal self-dual ternary $[32,16,9]$ codes, each ...

Criticality analysis of the storage tubes for irradiated fuel elements from the IEA-R1 with the MCNP code

International Nuclear Information System (INIS)

Maragni, M.G.; Moreira, J.M.L.

1992-01-01

A criticality safety analysis has been carried out for the storage tubes for irradiated fuel elements from the IEA-R1 research reactor. The analysis utilized the MCNP computer code which allows exact simulations of complex geometries. Aiming reducing the amount of input data, the fuel element cross-sections have been spatially smeared out. The earth material interstice between fuel elements has been approximated conservatively as concrete because its composition was unknown. The storage tubes have been found subcritical for the most adverse conditions (water flooding and un-irradiated fuel elements). A similar analysis with the KENO-IV computer code overestimated the KEF result but still confirmed the criticality safety of the storage tubes. (author)

Insertion of reactivity (RIA) without scram in the reactor core IEA-R1 using code PARET

International Nuclear Information System (INIS)

Alves, Urias F.; Castrillo, Lazara S.; Lima, Fernando A.

2013-01-01

The modeling and analysis thermo hydraulics of a research reactor with MTR type fuel elements - Material Testing Reactor - was performed using the code PARET (Program for the Analysis of Reactor Transients) when in the system some external event is introduced that changed the reactivity in the reactor core. Transients of Reactivity Insertion of 0.5 , 1.5 and 2.0$/ 0.7s in the brazilian reactor IEA-R1 will be presented, and will be shown under what conditions it is possible to ensure the safe operation of its nucleus. (author)

The Aster code; Code Aster

Energy Technology Data Exchange (ETDEWEB)

Delbecq, J.M

1999-07-01

The Aster code is a 2D or 3D finite-element calculation code for structures developed by the R and D direction of Electricite de France (EdF). This dossier presents a complete overview of the characteristics and uses of the Aster code: introduction of version 4; the context of Aster (organisation of the code development, versions, systems and interfaces, development tools, quality assurance, independent validation); static mechanics (linear thermo-elasticity, Euler buckling, cables, Zarka-Casier method); non-linear mechanics (materials behaviour, big deformations, specific loads, unloading and loss of load proportionality indicators, global algorithm, contact and friction); rupture mechanics (G energy restitution level, restitution level in thermo-elasto-plasticity, 3D local energy restitution level, KI and KII stress intensity factors, calculation of limit loads for structures), specific treatments (fatigue, rupture, wear, error estimation); meshes and models (mesh generation, modeling, loads and boundary conditions, links between different modeling processes, resolution of linear systems, display of results etc..); vibration mechanics (modal and harmonic analysis, dynamics with shocks, direct transient dynamics, seismic analysis and aleatory dynamics, non-linear dynamics, dynamical sub-structuring); fluid-structure interactions (internal acoustics, mass, rigidity and damping); linear and non-linear thermal analysis; steels and metal industry (structure transformations); coupled problems (internal chaining, internal thermo-hydro-mechanical coupling, chaining with other codes); products and services. (J.S.)

Self-complementary circular codes in coding theory.

Science.gov (United States)

Fimmel, Elena; Michel, Christian J; Starman, Martin; Strüngmann, Lutz

2018-04-01

Self-complementary circular codes are involved in pairing genetic processes. A maximal [Formula: see text] self-complementary circular code X of trinucleotides was identified in genes of bacteria, archaea, eukaryotes, plasmids and viruses (Michel in Life 7(20):1-16 2017, J Theor Biol 380:156-177, 2015; Arquès and Michel in J Theor Biol 182:45-58 1996). In this paper, self-complementary circular codes are investigated using the graph theory approach recently formulated in Fimmel et al. (Philos Trans R Soc A 374:20150058, 2016). A directed graph [Formula: see text] associated with any code X mirrors the properties of the code. In the present paper, we demonstrate a necessary condition for the self-complementarity of an arbitrary code X in terms of the graph theory. The same condition has been proven to be sufficient for codes which are circular and of large size [Formula: see text] trinucleotides, in particular for maximal circular codes ([Formula: see text] trinucleotides). For codes of small-size [Formula: see text] trinucleotides, some very rare counterexamples have been constructed. Furthermore, the length and the structure of the longest paths in the graphs associated with the self-complementary circular codes are investigated. It has been proven that the longest paths in such graphs determine the reading frame for the self-complementary circular codes. By applying this result, the reading frame in any arbitrary sequence of trinucleotides is retrieved after at most 15 nucleotides, i.e., 5 consecutive trinucleotides, from the circular code X identified in genes. Thus, an X motif of a length of at least 15 nucleotides in an arbitrary sequence of trinucleotides (not necessarily all of them belonging to X) uniquely defines the reading (correct) frame, an important criterion for analyzing the X motifs in genes in the future.

Parallel R-matrix computation

International Nuclear Information System (INIS)

Heggarty, J.W.

1999-06-01

For almost thirty years, sequential R-matrix computation has been used by atomic physics research groups, from around the world, to model collision phenomena involving the scattering of electrons or positrons with atomic or molecular targets. As considerable progress has been made in the understanding of fundamental scattering processes, new data, obtained from more complex calculations, is of current interest to experimentalists. Performing such calculations, however, places considerable demands on the computational resources to be provided by the target machine, in terms of both processor speed and memory requirement. Indeed, in some instances the computational requirements are so great that the proposed R-matrix calculations are intractable, even when utilising contemporary classic supercomputers. Historically, increases in the computational requirements of R-matrix computation were accommodated by porting the problem codes to a more powerful classic supercomputer. Although this approach has been successful in the past, it is no longer considered to be a satisfactory solution due to the limitations of current (and future) Von Neumann machines. As a consequence, there has been considerable interest in the high performance multicomputers, that have emerged over the last decade which appear to offer the computational resources required by contemporary R-matrix research. Unfortunately, developing codes for these machines is not as simple a task as it was to develop codes for successive classic supercomputers. The difficulty arises from the considerable differences in the computing models that exist between the two types of machine and results in the programming of multicomputers to be widely acknowledged as a difficult, time consuming and error-prone task. Nevertheless, unless parallel R-matrix computation is realised, important theoretical and experimental atomic physics research will continue to be hindered. This thesis describes work that was undertaken in

Long non-coding RNA H19 suppresses retinoblastoma progression via counteracting miR-17-92 cluster.

Science.gov (United States)

Zhang, Aihui; Shang, Weiwei; Nie, Qiaoli; Li, Ting; Li, Suhui

2018-04-01

Long non-coding RNAs (lncRNAs) are frequently dysregulated and play important roles in many cancers. lncRNA H19 is one of the earliest discovered lncRNAs which has diverse roles in different cancers. However, the expression, roles, and action mechanisms of H19 in retinoblastoma are still largely unknown. In this study, we found that H19 is downregulated in retinoblastoma tissues and cell lines. Gain-of-function and loss-of-function assays showed that H19 inhibits retinoblastoma cell proliferation, induces retinoblastoma cell cycle arrest and cell apoptosis. Mechanistically, we identified seven miR-17-92 cluster binding sites on H19, and found that H19 directly bound to miR-17-92 cluster via these seven binding sites. Through binding to miR-17-92 cluster, H19 relieves the suppressing roles of miR-17-92 cluster on p21. Furthermore, H19 represses STAT3 activation induced by miR-17-92 cluster. Hence, our results revealed that H19 upregulates p21 expression, inhibits STAT3 phosphorylation, and downregulates the expression of STAT3 target genes BCL2, BCL2L1, and BIRC5. In addition, functional assays demonstrated that the mutation of miR-17-92 cluster binding sites on H19 abolished the proliferation inhibiting, cell cycle arrest and cell apoptosis inducing roles of H19 in retinoblastoma. In conclusion, our data suggested that H19 inhibits retinoblastoma progression via counteracting the roles of miR-17-92 cluster, and implied that enhancing the action of H19 may be a promising therapeutic strategy for retinoblastoma. © 2017 Wiley Periodicals, Inc.

Impact testing and analysis for structural code benchmarking

International Nuclear Information System (INIS)

Glass, R.E.

1989-01-01

Sandia National Laboratories, in cooperation with industry and other national laboratories, has been benchmarking computer codes (''Structural Code Benchmarking for the Analysis of Impact Response of Nuclear Material Shipping Cask,'' R.E. Glass, Sandia National Laboratories, 1985; ''Sample Problem Manual for Benchmarking of Cask Analysis Codes,'' R.E. Glass, Sandia National Laboratories, 1988; ''Standard Thermal Problem Set for the Evaluation of Heat Transfer Codes Used in the Assessment of Transportation Packages, R.E. Glass, et al., Sandia National Laboratories, 1988) used to predict the structural, thermal, criticality, and shielding behavior of radioactive materials packages. The first step in the benchmarking of the codes was to develop standard problem sets and to compare the results from several codes and users. This step for structural analysis codes has been completed as described in ''Structural Code Benchmarking for the Analysis of Impact Response of Nuclear Material Shipping Casks,'' R.E. Glass, Sandia National Laboratories, 1985. The problem set is shown in Fig. 1. This problem set exercised the ability of the codes to predict the response to end (axisymmetric) and side (plane strain) impacts with both elastic and elastic/plastic materials. The results from these problems showed that there is good agreement in predicting elastic response. Significant differences occurred in predicting strains for the elastic/plastic models. An example of the variation in predicting plastic behavior is given, which shows the hoop strain as a function of time at the impacting end of Model B. These differences in predicting plastic strains demonstrated a need for benchmark data for a cask-like problem. 6 refs., 5 figs

N-body simulations for f(R) gravity using a self-adaptive particle-mesh code

International Nuclear Information System (INIS)

Zhao Gongbo; Koyama, Kazuya; Li Baojiu

2011-01-01

We perform high-resolution N-body simulations for f(R) gravity based on a self-adaptive particle-mesh code MLAPM. The chameleon mechanism that recovers general relativity on small scales is fully taken into account by self-consistently solving the nonlinear equation for the scalar field. We independently confirm the previous simulation results, including the matter power spectrum, halo mass function, and density profiles, obtained by Oyaizu et al.[Phys. Rev. D 78, 123524 (2008)] and Schmidt et al.[Phys. Rev. D 79, 083518 (2009)], and extend the resolution up to k∼20 h/Mpc for the measurement of the matter power spectrum. Based on our simulation results, we discuss how the chameleon mechanism affects the clustering of dark matter and halos on full nonlinear scales.

Code package to analyse behavior of the WWER fuel rods in normal operation: TOPRA's code

International Nuclear Information System (INIS)

Scheglov, A.; Proselkov, V.

2001-01-01

This paper briefly describes the code package intended for analysis of WWER fuel rod characteristics. The package includes two computer codes: TOPRA-1 and TOPRA-2 for full-scale fuel rod analyses; MRZ and MKK codes for analyzing the separate sections of fuel rods in r-z and r-j geometry. The TOPRA's codes are developed on the base of PIN-mod2 version and verified against experimental results obtained in MR, MIR and Halden research reactors (in the framework of SOFIT, FGR-2 and FUMEX experimental programs). Comparative analysis of calculation results and results from post-reactor examination of the WWER-440 and WWER-1000 fuel rod are also made as additional verification of these codes. To avoid the enlarging of uncertainties in fuel behavior prediction as a result of simplifying of the fuel geometry, MKK and MRZ codes are developed on the basis of the finite element method with use of the three nodal finite elements. Results obtained in the course of the code verification indicate the possibility for application of the method and TOPRA's code for simplified engineering calculations of WWER fuel rods thermal-physical parameters. An analysis of maximum relative errors for predicting of the fuel rod characteristics in the range of the accepted parameter values is also presented in the paper

Truncation Depth Rule-of-Thumb for Convolutional Codes

Science.gov (United States)

Moision, Bruce

2009-01-01

In this innovation, it is shown that a commonly used rule of thumb (that the truncation depth of a convolutional code should be five times the memory length, m, of the code) is accurate only for rate 1/2 codes. In fact, the truncation depth should be 2.5 m/(1 - r), where r is the code rate. The accuracy of this new rule is demonstrated by tabulating the distance properties of a large set of known codes. This new rule was derived by bounding the losses due to truncation as a function of the code rate. With regard to particular codes, a good indicator of the required truncation depth is the path length at which all paths that diverge from a particular path have accumulated the minimum distance of the code. It is shown that the new rule of thumb provides an accurate prediction of this depth for codes of varying rates.

Coding Class

DEFF Research Database (Denmark)

Ejsing-Duun, Stine; Hansbøl, Mikala

Denne rapport rummer evaluering og dokumentation af Coding Class projektet1. Coding Class projektet blev igangsat i skoleåret 2016/2017 af IT-Branchen i samarbejde med en række medlemsvirksomheder, Københavns kommune, Vejle Kommune, Styrelsen for IT- og Læring (STIL) og den frivillige forening...... Coding Pirates2. Rapporten er forfattet af Docent i digitale læringsressourcer og forskningskoordinator for forsknings- og udviklingsmiljøet Digitalisering i Skolen (DiS), Mikala Hansbøl, fra Institut for Skole og Læring ved Professionshøjskolen Metropol; og Lektor i læringsteknologi, interaktionsdesign......, design tænkning og design-pædagogik, Stine Ejsing-Duun fra Forskningslab: It og Læringsdesign (ILD-LAB) ved Institut for kommunikation og psykologi, Aalborg Universitet i København. Vi har fulgt og gennemført evaluering og dokumentation af Coding Class projektet i perioden november 2016 til maj 2017...

Balanced and sparse Tamo-Barg codes

KAUST Repository

Halbawi, Wael; Duursma, Iwan; Dau, Hoang; Hassibi, Babak

2017-01-01

We construct balanced and sparse generator matrices for Tamo and Barg's Locally Recoverable Codes (LRCs). More specifically, for a cyclic Tamo-Barg code of length n, dimension k and locality r, we show how to deterministically construct a generator matrix where the number of nonzeros in any two columns differs by at most one, and where the weight of every row is d + r - 1, where d is the minimum distance of the code. Since LRCs are designed mainly for distributed storage systems, the results presented in this work provide a computationally balanced and efficient encoding scheme for these codes. The balanced property ensures that the computational effort exerted by any storage node is essentially the same, whilst the sparse property ensures that this effort is minimal. The work presented in this paper extends a similar result previously established for Reed-Solomon (RS) codes, where it is now known that any cyclic RS code possesses a generator matrix that is balanced as described, but is sparsest, meaning that each row has d nonzeros.

Balanced and sparse Tamo-Barg codes

KAUST Repository

Halbawi, Wael

2017-08-29

We construct balanced and sparse generator matrices for Tamo and Barg\\'s Locally Recoverable Codes (LRCs). More specifically, for a cyclic Tamo-Barg code of length n, dimension k and locality r, we show how to deterministically construct a generator matrix where the number of nonzeros in any two columns differs by at most one, and where the weight of every row is d + r - 1, where d is the minimum distance of the code. Since LRCs are designed mainly for distributed storage systems, the results presented in this work provide a computationally balanced and efficient encoding scheme for these codes. The balanced property ensures that the computational effort exerted by any storage node is essentially the same, whilst the sparse property ensures that this effort is minimal. The work presented in this paper extends a similar result previously established for Reed-Solomon (RS) codes, where it is now known that any cyclic RS code possesses a generator matrix that is balanced as described, but is sparsest, meaning that each row has d nonzeros.

Solving Differential Equations in R: Package deSolve

Directory of Open Access Journals (Sweden)

Karline Soetaert

2010-02-01

Full Text Available In this paper we present the R package deSolve to solve initial value problems (IVP written as ordinary differential equations (ODE, differential algebraic equations (DAE of index 0 or 1 and partial differential equations (PDE, the latter solved using the method of lines approach. The differential equations can be represented in R code or as compiled code. In the latter case, R is used as a tool to trigger the integration and post-process the results, which facilitates model development and application, whilst the compiled code significantly increases simulation speed. The methods implemented are efficient, robust, and well documented public-domain Fortran routines. They include four integrators from the ODEPACK package (LSODE, LSODES, LSODA, LSODAR, DVODE and DASPK2.0. In addition, a suite of Runge-Kutta integrators and special-purpose solvers to efficiently integrate 1-, 2- and 3-dimensional partial differential equations are available. The routines solve both stiff and non-stiff systems, and include many options, e.g., to deal in an efficient way with the sparsity of the Jacobian matrix, or finding the root of equations. In this article, our objectives are threefold: (1 to demonstrate the potential of using R for dynamic modeling, (2 to highlight typical uses of the different methods implemented and (3 to compare the performance of models specified in R code and in compiled code for a number of test cases. These comparisons demonstrate that, if the use of loops is avoided, R code can efficiently integrate problems comprising several thousands of state variables. Nevertheless, the same problem may be solved from 2 to more than 50 times faster by using compiled code compared to an implementation using only R code. Still, amongst the benefits of R are a more flexible and interactive implementation, better readability of the code, and access to R’s high-level procedures. deSolve is the successor of package odesolve which will be deprecated in

Long non-coding RNA TUG1 acts as a miR-26a sponge in human glioma cells.

Science.gov (United States)

Li, Jun; An, Gang; Zhang, Meng; Ma, Qingfang

2016-09-02

Long non-coding RNA taurine upregulated gene 1 (TUG1) acts as an important regulator in cancer pathogenesis; however, its functional mechanism in glioma development remains unclear. This study aims to explore the potential function of TUG1 in glioma by sponging miR-26a. The expression of TUG1, miR-26a, and phosphatase and tensin homolog (PTEN) in 20 paired glioma tissues was detected by quantitative real-time PCR and subjected to correlation analysis. Bioinformatics analysis was performed by using DIANA Tools. Abnormal TUG1 expression was conducted in two glioma cells to analyze its regulation on miR-26a and PTEN using real-time PCR, western blot, and luciferase reporter assay. TUG1 expression was confirmed to be upregulated in glioma tissues, and showed an inverse correlation with downregulated miR-26a. TUG1 could negatively regulate the expression of miR-26a in glioma cells. The bioinformatics prediction revealed putative miR-26a binding sites within TUG1 transcripts. Further experiments demonstrated the positive regulation of TUG1 on the miR-26a target, PTEN, wherein TUG1 could inhibit the negative regulation of miR-26a on PTEN by binding its 3'UTR. Additionally, the expression of PTEN was also upregulated in glioma tissues, showing a positive or negative correlation with TUG1 or miR-26a, respectively. TUG1 could serve as a miR-26a sponge in human glioma cells, contributing to the upregulation of PTEN. This study revealed a new TUG1/miR-26a/PTEN regulatory mechanism and provided a further understanding of the tumor-suppressive role of TUG1 in glioma development. Copyright © 2016 Elsevier Inc. All rights reserved.

Metaprogramming in R

DEFF Research Database (Denmark)

Mailund, Thomas

Learn how to manipulate functions and expressions to modify how the R language interprets itself. This book is an introduction to metaprogramming in the R language, so you will write programs to manipulate other programs. Metaprogramming in R shows you how to treat code as data that you can gener...

L’Application des Codes de Costas et des Codes a Congruences Quadratiques a la Compression d’Impulsion Numerique (The Application of Cost, Codes and Quadratic Congruence Codes to the Compression of Numeric Impulsion)

Science.gov (United States)

1991-12-01

de produire des diagrammes d’ambigult& en forme de punaise avec de faibles lobes...particularit& de produire des diagrammes d’ambiguiLt6 en forme de punaise tout en ayant de faibles lobes secondaires. Ce rapport traite des diff6rentes m6thodes...les codes de Costas, les r~sultats obtenus mantrent que les codes de Golomb of frent de mains bonnes possibi- lit ~s que les codes de Welch pour

Tumor-targeting Salmonella typhimurium A1-R Inhibits Osteosarcoma Angiogenesis in the In Vivo Gelfoam® Assay Visualized by Color-coded Imaging.

Science.gov (United States)

Kiyuna, Tasuku; Tome, Yasunori; Uehara, Fuminari; Murakami, Takashi; Zhang, Yong; Zhao, Ming; Kanaya, Fuminori; Hoffman, Robert M

2018-01-01

We previously developed a color-coded imaging model that can quantify the length of nascent blood vessels using Gelfoam® implanted in nestin-driven green fluorescent protein (ND-GFP) nude mice. In this model, nascent blood vessels selectively express GFP. We also previously showed that osteosarcoma cells promote angiogenesis in this assay. We have also previously demonstrated the tumor-targeting bacteria Salmonella typhimurium A1-R (S. typhimurium A1-R) can inhibit or regress all tested tumor types in mouse models. The aim of the present study was to determine if S. typhimurium A1-R could inhibit osteosarcoma angiogenesis in the in vivo Gelfoam® color-coded imaging assay. Gelfoam® was implanted subcutaneously in ND-GFP nude mice. Skin flaps were made 7 days after implantation and 143B-RFP human osteosarcoma cells expressing red fluorescent protein (RFP) were injected into the implanted Gelfoam. After establishment of tumors in the Gelfoam®, control-group mice were treated with phosphate buffered saline via tail-vein injection (iv) and the experimental group was treated with S. typhimurium A1-R iv Skin flaps were made at day 7, 14, 21, and 28 after implantation of the Gelfoam® to allow imaging of vascularization in the Gelfoam® using a variable-magnification small-animal imaging system and confocal fluorescence microscopy. Nascent blood vessels expressing ND-GFP extended into the Gelfoam® over time in both groups. However, the extent of nascent blood-vessel growth was significantly inhibited by S. typhimurium A1-R treatment by day 28. The present results indicate S. typhimurium A1-R has potential for anti-angiogenic targeted therapy of osteosarcoma. Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

N-body simulations for f(R) gravity using a self-adaptive particle-mesh code

Science.gov (United States)

Zhao, Gong-Bo; Li, Baojiu; Koyama, Kazuya

2011-02-01

We perform high-resolution N-body simulations for f(R) gravity based on a self-adaptive particle-mesh code MLAPM. The chameleon mechanism that recovers general relativity on small scales is fully taken into account by self-consistently solving the nonlinear equation for the scalar field. We independently confirm the previous simulation results, including the matter power spectrum, halo mass function, and density profiles, obtained by Oyaizu [Phys. Rev. DPRVDAQ1550-7998 78, 123524 (2008)10.1103/PhysRevD.78.123524] and Schmidt [Phys. Rev. DPRVDAQ1550-7998 79, 083518 (2009)10.1103/PhysRevD.79.083518], and extend the resolution up to k˜20h/Mpc for the measurement of the matter power spectrum. Based on our simulation results, we discuss how the chameleon mechanism affects the clustering of dark matter and halos on full nonlinear scales.

R-ES-ONANCE--IJa-nu-a-rY

Indian Academy of Sciences (India)

panying poster. 1 How many of the amino acids are chiral? 2 All chiral amino acids have theL configuration; however, in the R/S nomenclature only one has the R configuration. Which one, and why? 3 Which amino acids have more than one asymmetric centre? 4 What are the two common letter-code systems used to repre-.

Fast convolutional sparse coding using matrix inversion lemma

Czech Academy of Sciences Publication Activity Database

Šorel, Michal; Šroubek, Filip

2016-01-01

Roč. 55, č. 1 (2016), s. 44-51 ISSN 1051-2004 R&D Projects: GA ČR GA13-29225S Institutional support: RVO:67985556 Keywords : Convolutional sparse coding * Feature learning * Deconvolution networks * Shift-invariant sparse coding Subject RIV: JD - Computer Applications, Robotics Impact factor: 2.337, year: 2016 http://library.utia.cas.cz/separaty/2016/ZOI/sorel-0459332.pdf

Polynomial weights and code constructions

DEFF Research Database (Denmark)

Massey, J; Costello, D; Justesen, Jørn

1973-01-01

polynomial included. This fundamental property is then used as the key to a variety of code constructions including 1) a simplified derivation of the binary Reed-Muller codes and, for any primepgreater than 2, a new extensive class ofp-ary "Reed-Muller codes," 2) a new class of "repeated-root" cyclic codes...... of long constraint length binary convolutional codes derived from2^r-ary Reed-Solomon codes, and 6) a new class ofq-ary "repeated-root" constacyclic codes with an algebraic decoding algorithm.......For any nonzero elementcof a general finite fieldGF(q), it is shown that the polynomials(x - c)^i, i = 0,1,2,cdots, have the "weight-retaining" property that any linear combination of these polynomials with coefficients inGF(q)has Hamming weight at least as great as that of the minimum degree...

Decoding of interleaved Reed-Solomon codes using improved power decoding

DEFF Research Database (Denmark)

Puchinger, Sven; Rosenkilde ne Nielsen, Johan

2017-01-01

We propose a new partial decoding algorithm for m-interleaved Reed-Solomon (IRS) codes that can decode, with high probability, a random error of relative weight 1 − Rm/m+1 at all code rates R, in time polynomial in the code length n. For m > 2, this is an asymptotic improvement over the previous...... state-of-the-art for all rates, and the first improvement for R > 1/3 in the last 20 years. The method combines collaborative decoding of IRS codes with power decoding up to the Johnson radius....

Abstraction carrying code and resource-awareness

OpenAIRE

Hermenegildo, Manuel V.; Albert Albiol, Elvira; López García, Pedro; Puebla Sánchez, Alvaro Germán

2005-01-01

Proof-Carrying Code (PCC) is a general approach to mobile code safety in which the code supplier augments the program with a certifícate (or proof). The intended benefit is that the program consumer can locally validate the certifícate w.r.t. the "untrusted" program by means of a certifícate checker—a process which should be much simpler, eíñcient, and automatic than generating the original proof. Abstraction Carrying Code (ACC) is an enabling technology for PCC in which an abstract mod...

Linear tree codes and the problem of explicit constructions

Czech Academy of Sciences Publication Activity Database

Pudlák, Pavel

2016-01-01

Roč. 490, February 1 (2016), s. 124-144 ISSN 0024-3795 R&D Projects: GA ČR GBP202/12/G061 Institutional support: RVO:67985840 Keywords : tree code * error correcting code * triangular totally nonsingular matrix Subject RIV: BA - General Mathematics Impact factor: 0.973, year: 2016 http://www.sciencedirect.com/science/article/pii/S002437951500645X

Hardwarearchitektur für einen universellen LDPC Decoder

Directory of Open Access Journals (Sweden)

C. Beuschel

2009-05-01

Full Text Available Im vorliegenden Beitrag wird eine universelle Decoderarchitektur für einen Low-Density Parity-Check (LDPC Code Decoder vorgestellt. Anders als bei den in der Literatur häufig beschriebenen Architekturen für strukturierte Codes ist die hier vorgestellte Architektur frei programmierbar, so dass jeder beliebige LDPC Code durch eine Änderung der Initialisierung des Speichers für die Prüfmatrix mit derselben Hardware decodiert werden kann. Die größte Herausforderung beim Entwurf von teilparallelen LDPC Decoder Architekturen liegt im konfliktfreien Datenaustausch zwischen mehreren parallelen Speichern und Berechnungseinheiten, wozu ein Mapping und Scheduling Algorithmus benötigt wird. Der hier vorgestellte Algorithmus stützt sich auf Graphentheorie und findet für jeden beliebigen LDPC Code eine für die Architektur optimale Lösung. Damit sind keine Wartezyklen notwendig und die Parallelität der Architektur wird zu jedem Zeitpunkt voll ausgenutzt.

R-ES-ONAN-CE

Indian Academy of Sciences (India)

B N Goswami. 16 Algorithms. Algorithms for Sorting and. Searching. R K Shyamasundar. 33 Error Correcting Codes. Reed Solomon Codes. Prifi Shankar. 48 Know Your Chromosomes The Uniqueness of Sex. Chromosomes. Vani Brahmachari. GENERAL ARTICLES. 58 Transfinite Numbers. S M Srivastava. What is Infinity ...

Explicit Constructions and Bounds for Batch Codes with Restricted Size of Reconstruction Sets

OpenAIRE

Thomas, Eldho K.; Skachek, Vitaly

2017-01-01

Linear batch codes and codes for private information retrieval (PIR) with a query size $t$ and a restricted size $r$ of the reconstruction sets are studied. New bounds on the parameters of such codes are derived for small values of $t$ or of $r$ by providing corresponding constructions. By building on the ideas of Cadambe and Mazumdar, a new bound in a recursive form is derived for batch codes and PIR codes.

Analysis of OECD/CSNI ISP-42 phase A PANDA experiment using coupled code R5G (RELAP5-GOTHIC)

International Nuclear Information System (INIS)

Bencik, V.; Debrecin, N.; Grgic, D.; Bajs, T.

2010-01-01

In the paper, the results of the analysis of OECD/CSNI ISP-42 Phase A experiment at PANDA facility using stand-alone codes RELAP5/mod3.3 and GOTHIC 7.2b as well as coupled code R5G (RELAP5/mod3.3-GOTHIC 7.2b) are presented. PANDA is a large-scale thermal-hydraulic test facility installed at PSI (Paul Scherrer Institute) in Switzerland. The OECD/CSNI ISP-42 test consists of six sequential phases (Phase A through F). The present work deals with the post-test calculation of the Phase A, including the break of the main steam line and the Passive Containment Cooling (PCC) System Start-Up. The objective of the test is to investigate the start-up phenomenology of passive cooling system when steam is injected into cold vessel filled with air. The calculation was performed using stand-alone RELAP5/mod3.3 and GOTHIC 7.2b models, and then the same calculation was performed using coupled code with RELAP5 being responsible for reactor part of the model and GOTHIC being responsible for containment part of the model. The prediction capability, running time and modeling aspects were discussed for all three cases. (authors)

Beginning Data Science in R

DEFF Research Database (Denmark)

Mailund, Thomas

in R details how data science is a combination of statistics, computational science, and machine learning. You’ll see how to efficiently structure and mine data to extract useful patterns and build mathematical models. This requires computational methods and programming, and R is an ideal programming...... language for this. This book is based on a number of lecture notes for classes the author has taught on data science and statistical programming using the R programming language. Modern data analysis requires computational skills and usually a minimum of programming. You will: Perform data science...... and analytics using statistics and the R programming language Visualize and explore data, including working with large data sets found in big data Build an R package Test and check your code Practice version control Profile and optimize your code...

Long non-coding RNA TUG1 promotes cervical cancer progression by regulating the miR-138-5p-SIRT1 axis.

Science.gov (United States)

Zhu, Jie; Shi, Huirong; Liu, Huina; Wang, Xiaojuan; Li, Fengmei

2017-09-12

Increasing evidences showed that long non-coding RNAs (lncRNAs) play vital roles in tumor progression. Recent studies indicated that lncRNA TUG1 was upregulated and promoted tumor processes in several cancers. However, the expression and underlying mechanism of TUG1 in cervical cancer remain unclear. In the present study, we found that TUG1 expression was upregulated in cervical cancer tissues and correlated with advanced clinical features and poor overall survival. TUG1 knockdown suppressed cervical cancer cell growth and metastasis in vitro and tumor growth in vivo . In addition, our results indicated that TUG1 could act as an endogenous sponge by directly binding to miR-138-5p and suppressed miR-138-5p expression. Furthermore, we found that TUG1 could reverse the inhibitory effect of miR-138-5p on cervical cancer cells processes, which might be involved in the activation of SIRT1, a target gene of miR-138-5p, and activation of Wnt/β-catenin signaling pathway. Taken together, we elucidated that TUG1 might promote cervical cancer malignant progression via miR-138-5p-SIRT1-Wnt/β-catenin signaling pathway axis.

Average Likelihood Methods of Classification of Code Division Multiple Access (CDMA)

Science.gov (United States)

2016-05-01

subject to code matrices that follows the structure given by (113). [⃗ yR y⃗I ] = √ Es 2L [ GR1 −GI1 GI2 GR2 ] [ QR −QI QI QR ] [⃗ bR b⃗I ] + [⃗ nR n⃗I... QR ] [⃗ b+ b⃗− ] + [⃗ n+ n⃗− ] (115) The average likelihood for type 4 CDMA (116) is a special case of type 1 CDMA with twice the code length and...AVERAGE LIKELIHOOD METHODS OF CLASSIFICATION OF CODE DIVISION MULTIPLE ACCESS (CDMA) MAY 2016 FINAL TECHNICAL REPORT APPROVED FOR PUBLIC RELEASE

Turbo Pascal Computer Code for PIXE Analysis

International Nuclear Information System (INIS)

Darsono

2002-01-01

To optimal utilization of the 150 kV ion accelerator facilities and to govern the analysis technique using ion accelerator, the research and development of low energy PIXE technology has been done. The R and D for hardware of the low energy PIXE installation in P3TM have been carried on since year 2000. To support the R and D of PIXE accelerator facilities in harmonize with the R and D of the PIXE hardware, the development of PIXE software for analysis is also needed. The development of database of PIXE software for analysis using turbo Pascal computer code is reported in this paper. This computer code computes the ionization cross-section, the fluorescence yield, and the stopping power of elements also it computes the coefficient attenuation of X- rays energy. The computer code is named PIXEDASIS and it is part of big computer code planed for PIXE analysis that will be constructed in the near future. PIXEDASIS is designed to be communicative with the user. It has the input from the keyboard. The output shows in the PC monitor, which also can be printed. The performance test of the PIXEDASIS shows that it can be operated well and it can provide data agreement with data form other literatures. (author)

Massive Predictive Modeling using Oracle R Enterprise

CERN Multimedia

CERN. Geneva

2014-01-01

R is fast becoming the lingua franca for analyzing data via statistics, visualization, and predictive analytics. For enterprise-scale data, R users have three main concerns: scalability, performance, and production deployment. Oracle's R-based technologies - Oracle R Distribution, Oracle R Enterprise, Oracle R Connector for Hadoop, and the R package ROracle - address these concerns. In this talk, we introduce Oracle's R technologies, highlighting how each enables R users to achieve scalability and performance while making production deployment of R results a natural outcome of the data analyst/scientist efforts. The focus then turns to Oracle R Enterprise with code examples using the transparency layer and embedded R execution, targeting massive predictive modeling. One goal behind massive predictive modeling is to build models per entity, such as customers, zip codes, simulations, in an effort to understand behavior and tailor predictions at the entity level. Predictions...

MOMCON: A spectral code for obtaining three-dimensional magnetohydrodynamic equilibria

International Nuclear Information System (INIS)

Hirshman, S.P.; Lee, D.K.

1986-01-01

A new code, MOMCON (spectral moments code with constraints), is described that computes three-dimensional ideal magnetohydrodynamic (MHD) equilibria in a fixed toroidal domain using a Fourier expansion for the inverse coordinates (R, Z) representing nested magnetic surfaces. A set of nonlinear coupled ordinary differential equations for the spectral coefficients of (R, Z) is solved using an accelerated steepest descent method. A stream function, lambda, is introduced to improve the mode convergence properties of the Fourier series for R and Z. The convergence rate of the R-Z spectra is optimized on each flux surface by solving nonlinear constraint equations relating the m>=2 spectral coefficients of R and Z. (orig.)

Performance measures for transform data coding.

Science.gov (United States)

Pearl, J.; Andrews, H. C.; Pratt, W. K.

1972-01-01

This paper develops performance criteria for evaluating transform data coding schemes under computational constraints. Computational constraints that conform with the proposed basis-restricted model give rise to suboptimal coding efficiency characterized by a rate-distortion relation R(D) similar in form to the theoretical rate-distortion function. Numerical examples of this performance measure are presented for Fourier, Walsh, Haar, and Karhunen-Loeve transforms.

Analytical computation of thermodynamic performance parameters of actual vapour compression refrigeration system with R22, R32, R134a, R152a, R290 and R1270

Directory of Open Access Journals (Sweden)

Vali Shaik Sharmas

2018-01-01

Full Text Available The present work focuses on analytical computation of thermodynamic performance of actual vapour compression refrigeration system by using six pure refrigerants. The refrigerants are namely R22, R32, R134a, R152a, R290 and R1270 respectively. A MATLAB code is developed to compute the thermodynamic performance parameters of actual vapour compression system such as refrigeration effect, compressor work, COP, power per ton of refrigeration, compressor discharge temperature and volumetric refrigeration capacity at condensing and evaporating temperatures of 54.4oC and 7.2oC respectively. Analytical results exhibited that COP of both R32 and R134a are 15.95% and 11.71% higher among the six investigated refrigerants. However R32 and R134a cannot be replaced directly into R22 system. This is due to their higher compressor discharge temperature and poor volumetric capacity respectively. The discharge temperature of both R1270 and R290 are lower than R22 by 20-26oC. Volumetric refrigeration capacity of R1270 (3197 kJ/m3 is very close to that of volumetric capacity of R22 (3251 kJ/m3. Both R1270 and R290 shows good miscibility with R22 mineral oil. Overall R1270 would be a suitable ecofriendly refrigerant to replace R22 from the stand point of ODP, GWP, volumetric capacity, discharge temperature and miscibility with mineral oil although its COP is lower.

LFSC - Linac Feedback Simulation Code

Energy Technology Data Exchange (ETDEWEB)

Ivanov, Valentin; /Fermilab

2008-05-01

The computer program LFSC (Code>) is a numerical tool for simulation beam based feedback in high performance linacs. The code LFSC is based on the earlier version developed by a collective of authors at SLAC (L.Hendrickson, R. McEwen, T. Himel, H. Shoaee, S. Shah, P. Emma, P. Schultz) during 1990-2005. That code was successively used in simulation of SLC, TESLA, CLIC and NLC projects. It can simulate as pulse-to-pulse feedback on timescale corresponding to 5-100 Hz, as slower feedbacks, operating in the 0.1-1 Hz range in the Main Linac and Beam Delivery System. The code LFSC is running under Matlab for MS Windows operating system. It contains about 30,000 lines of source code in more than 260 subroutines. The code uses the LIAR ('Linear Accelerator Research code') for particle tracking under ground motion and technical noise perturbations. It uses the Guinea Pig code to simulate the luminosity performance. A set of input files includes the lattice description (XSIF format), and plane text files with numerical parameters, wake fields, ground motion data etc. The Matlab environment provides a flexible system for graphical output.

Metaprogramming in R

DEFF Research Database (Denmark)

Mailund, Thomas

Learn how to manipulate functions and expressions to modify how the R language interprets itself. This book is an introduction to metaprogramming in the R language, so you will write programs to manipulate other programs. Metaprogramming in R shows you how to treat code as data that you can...... generate, analyze, or modify. R is a very high-level language where all operations are functions and all functions are data that can be manipulated. This book shows you how to leverage R's natural flexibility in how function calls and expressions are evaluated, to create small domain-specific languages...... to extend R within the R language itself. You will: Find out about the anatomy of a function in R Look inside a function call Work with R expressions and environments Manipulate expressions in R Use substitutions...

Metaprogramming in R

DEFF Research Database (Denmark)

Mailund, Thomas

2017-01-01

Learn how to manipulate functions and expressions to modify how the R language interprets itself. This book is an introduction to metaprogramming in the R language, so you will write programs to manipulate other programs. Metaprogramming in R shows you how to treat code as data that you can...... generate, analyze, or modify. R is a very high-level language where all operations are functions and all functions are data that can be manipulated. This book shows you how to leverage R's natural flexibility in how function calls and expressions are evaluated, to create small domain-specific languages...... to extend R within the R language itself. You will: Find out about the anatomy of a function in R Look inside a function call Work with R expressions and environments Manipulate expressions in R Use substitutions...

Construction of Short-length High-rates Ldpc Codes Using Difference Families

OpenAIRE

Deny Hamdani; Ery Safrianti

2007-01-01

Low-density parity-check (LDPC) code is linear-block error-correcting code defined by sparse parity-check matrix. It isdecoded using the massage-passing algorithm, and in many cases, capable of outperforming turbo code. This paperpresents a class of low-density parity-check (LDPC) codes showing good performance with low encoding complexity.The code is constructed using difference families from combinatorial design. The resulting code, which is designed tohave short code length and high code r...

Stimulus reference frame and neural coding precision

Czech Academy of Sciences Publication Activity Database

Košťál, Lubomír

2016-01-01

Roč. 71, Apr 2016 (2016), s. 22-27 ISSN 0022-2496 R&D Projects: GA ČR(CZ) GA15-08066S Institutional support: RVO:67985823 Keywords : Fisher information * coding accuracy * measurement scale * Jeffreys prior Subject RIV: FH - Neurology Impact factor: 1.377, year: 2016

Computerized adaptive and multistage testing with R using packages catR and mstR

CERN Document Server

Magis, David; von Davier, Alina A

2017-01-01

The goal of this guide and manual is to provide a practical and brief overview of the theory on computerized adaptive testing (CAT) and multistage testing (MST) and to illustrate the methodologies and applications using R open source language and several data examples.  Implementation relies on the R packages catR and mstR that have been already or are being developed by the first author (with the team) and that include some of the newest research algorithms on the topic. The book covers many topics along with the R-code: the basics of R, theoretical overview of CAT and MST, CAT designs, CAT assembly methodologies, CAT simulations, catR package, CAT applications, MST designs, IRT-based MST methodologies, tree-based MST methodologies, mstR package, and MST applications.  CAT has been used in many large-scale assessments over recent decades, and MST has become very popular in recent years.  R open source language also has become one of the most useful tools for applications in almost all fields, including b...

A modified carrier-to-code leveling method for retrieving ionospheric observables and detecting short-term temporal variability of receiver differential code biases

Science.gov (United States)

Zhang, Baocheng; Teunissen, Peter J. G.; Yuan, Yunbin; Zhang, Xiao; Li, Min

2018-03-01

Sensing the ionosphere with the global positioning system involves two sequential tasks, namely the ionospheric observable retrieval and the ionospheric parameter estimation. A prominent source of error has long been identified as short-term variability in receiver differential code bias (rDCB). We modify the carrier-to-code leveling (CCL), a method commonly used to accomplish the first task, through assuming rDCB to be unlinked in time. Aside from the ionospheric observables, which are affected by, among others, the rDCB at one reference epoch, the Modified CCL (MCCL) can also provide the rDCB offsets with respect to the reference epoch as by-products. Two consequences arise. First, MCCL is capable of excluding the effects of time-varying rDCB from the ionospheric observables, which, in turn, improves the quality of ionospheric parameters of interest. Second, MCCL has significant potential as a means to detect between-epoch fluctuations experienced by rDCB of a single receiver.

A universal Model-R Coupler to facilitate the use of R functions for model calibration and analysis

Science.gov (United States)

Wu, Yiping; Liu, Shuguang; Yan, Wende

2014-01-01

Mathematical models are useful in various fields of science and engineering. However, it is a challenge to make a model utilize the open and growing functions (e.g., model inversion) on the R platform due to the requirement of accessing and revising the model's source code. To overcome this barrier, we developed a universal tool that aims to convert a model developed in any computer language to an R function using the template and instruction concept of the Parameter ESTimation program (PEST) and the operational structure of the R-Soil and Water Assessment Tool (R-SWAT). The developed tool (Model-R Coupler) is promising because users of any model can connect an external algorithm (written in R) with their model to implement various model behavior analyses (e.g., parameter optimization, sensitivity and uncertainty analysis, performance evaluation, and visualization) without accessing or modifying the model's source code.

Reactivity-worth estimates of the OSMOSE samples in the MINERVE reactor R1-MOX, R2-UO2 and MORGANE/R configurations.

Energy Technology Data Exchange (ETDEWEB)

Zhong, Z.; Klann, R. T.; Nuclear Engineering Division

2007-08-03

An initial series of calculations of the reactivity-worth of the OSMOSE samples in the MINERVE reactor with the R2-UO2 and MORGANE/R core configuration were completed. The calculation model was generated using the lattice physics code DRAGON. In addition, an initial comparison of calculated values to experimental measurements was performed based on preliminary results for the R1-MOX configuration.

MIFT: GIFT Combinatorial Geometry Input to VCS Code

Science.gov (United States)

1977-03-01

r-w w-^ H ^ß0318is CQ BRL °RCUMr REPORT NO. 1967 —-S: ... MIFT: GIFT COMBINATORIAL GEOMETRY INPUT TO VCS CODE Albert E...TITLE (and Subtitle) MIFT: GIFT Combinatorial Geometry Input to VCS Code S. TYPE OF REPORT & PERIOD COVERED FINAL 6. PERFORMING ORG. REPORT NUMBER...Vehicle Code System (VCS) called MORSE was modified to accept the GIFT combinatorial geometry package. GIFT , as opposed to the geometry package

Documentation of the heat conduction code TRANCO

International Nuclear Information System (INIS)

Callahan, G.D.

1975-01-01

A transient heat conduction code used for thermal, thermoelastic, thermoelastic/plastic, and thermo/viscoelastic analyses is presented. The code can solve two-dimensional X-Y and axially symmetric R-theta-z thermal problems with the following conditions: constant temperature, constant flux, convective, or adiabatic boundary conditions; time-dependent or constant internal heat generation; and anisotropic thermal conductivities

Using DEWIS and R for Multi-Staged Statistics e-Assessments

Science.gov (United States)

Gwynllyw, D. Rhys; Weir, Iain S.; Henderson, Karen L.

2016-01-01

We demonstrate how the DEWIS e-Assessment system may use embedded R code to facilitate the assessment of students' ability to perform involved statistical analyses. The R code has been written to emulate SPSS output and thus the statistical results for each bespoke data set can be generated efficiently and accurately using standard R routines.…

Analyses for experiment on sodium-water reaction temperature by the CHAMPAGNE code

International Nuclear Information System (INIS)

Yoshioka, Naoki; Kishida, Masako; Yamada, Yumi

2000-03-01

In this work, analyses on sodium-water reaction temperature in the new SWAT-1(SWAT-1R) test were completed by the CHAMPAGNE code in order to understand void and velocity distribution in sodium system, which was difficult to be measured in experiments. The application method of the RELAP5/Mod2 code was investigated to LMFBR steam generator (SG) blow down analysis, too. The following results were obtained. (1) Analyses on sodium-water reaction temperature in the SWAT-1R test. 1) Analyses were carried out for the SWAT-1R test under the condition water leak rate 600 g/s by treating the pressure loss coefficient, the interface friction coefficient and the coefficient related to reaction rate as parameters. The effect and mechanism of each parameter on the shape of reaction zone were well understood by these analyses. 2) The void and velocity distribution in sodium system were estimated by use of the most suitable parameters. These analytical results are expected to be useful for planning of the SWAT-1R test and evaluation of test result. (2) Investigation of the RELAP5/Mod2 code. 1) The items to be improved in the RELAP5/Mod2 code were clarified to apply this code to the FBR SG blow down analysis. 2) One of these items was an addition of the shell-side (sodium-side) model. A sodium-side model was designed and added to the RELAP5/Mod2 code. Test calculations were carried out by this improved code and the basic function of this code was confirmed. (author)

Using R via PHP for Teaching Purposes: R-php

Directory of Open Access Journals (Sweden)

Angelo Mineo

2006-10-01

Full Text Available This paper deals with the R-php statistical software, that is an environment for statistical analysis, freely accessible and attainable through the World Wide Web, based on R. Indeed, this software uses, as “engine” for statistical analyses, R via PHP and its design has been inspired by a paper of de Leeuw (1997. R-php is based on two modules: a base module and a point-and-click module. R-php base allows the simple editing of R code in a form. R-php point-and-click allows some statistical analyses by means of a graphical user interface (GUI: then, to use this module it is not necessary for the user to know the R environment, but all the allowed analyses can be performed by using the computer mouse. We think that this tool could be particularly useful for teaching purposes: one possible use could be in a University computer laboratory to permit a smooth approach of students to R.

Emergency readmissions to paediatric surgery and urology: The impact of inappropriate coding.

Science.gov (United States)

Peeraully, R; Henderson, K; Davies, B

2016-04-01

Introduction In England, emergency readmissions within 30 days of hospital discharge after an elective admission are not reimbursed if they do not meet Payment by Results (PbR) exclusion criteria. However, coding errors could inappropriately penalise hospitals. We aimed to assess the accuracy of coding for emergency readmissions. Methods Emergency readmissions attributed to paediatric surgery and urology between September 2012 and August 2014 to our tertiary referral centre were retrospectively reviewed. Payment by Results (PbR) coding data were obtained from the hospital's Family Health Directorate. Clinical details were obtained from contemporaneous records. All readmissions were categorised as appropriately coded (postoperative or nonoperative) or inappropriately coded (planned surgical readmission, unrelated surgical admission, unrelated medical admission or coding error). Results Over the 24-month period, 241 patients were coded as 30-day readmissions, with 143 (59%) meeting the PbR exclusion criteria. Of the remaining 98 (41%) patients, 24 (25%) were inappropriately coded as emergency readmissions. These readmissions resulted in 352 extra bed days, of which 117 (33%) were attributable to inappropriately coded cases. Conclusions One-quarter of non-excluded emergency readmissions were inappropriately coded, accounting for one-third of additional bed days. As a stay on a paediatric ward costs up to £500 a day, the potential cost to our institution due to inappropriate readmission coding was over £50,000. Diagnoses and the reason for admission for each care episode should be accurately documented and coded, and readmission data should be reviewed at a senior clinician level.

LFSC - Linac Feedback Simulation Code

International Nuclear Information System (INIS)

Ivanov, Valentin; Fermilab

2008-01-01

The computer program LFSC ( ) is a numerical tool for simulation beam based feedback in high performance linacs. The code LFSC is based on the earlier version developed by a collective of authors at SLAC (L.Hendrickson, R. McEwen, T. Himel, H. Shoaee, S. Shah, P. Emma, P. Schultz) during 1990-2005. That code was successively used in simulation of SLC, TESLA, CLIC and NLC projects. It can simulate as pulse-to-pulse feedback on timescale corresponding to 5-100 Hz, as slower feedbacks, operating in the 0.1-1 Hz range in the Main Linac and Beam Delivery System. The code LFSC is running under Matlab for MS Windows operating system. It contains about 30,000 lines of source code in more than 260 subroutines. The code uses the LIAR ('Linear Accelerator Research code') for particle tracking under ground motion and technical noise perturbations. It uses the Guinea Pig code to simulate the luminosity performance. A set of input files includes the lattice description (XSIF format), and plane text files with numerical parameters, wake fields, ground motion data etc. The Matlab environment provides a flexible system for graphical output

SHREDI a removal diffusion shielding code for x-y and r-z geometries

International Nuclear Information System (INIS)

Daneri, A.; Toselli, G.

1974-01-01

The SHREDI, a removal diffusion neutron shielding code written in FORTRAN for IBM 370/165, is presented. The code computes neutron fluxes or adjoint fluxes and activations in bidimensional sections of the shield. It is also possible to consider shielding points with the same coordinate (y or z) (monodimensional problems)

Skew cyclic codes over F_q+uF_q+vF_q+uvF_q

Directory of Open Access Journals (Sweden)

Ting Yao

2015-09-01

Full Text Available In this paper, we study skew cyclic codes over the ring $R=F_q+uF_q+vF_q+uvF_q$, where $u^{2}=u,v^{2}=v,uv=vu$, $q=p^{m}$ and $p$ is an odd prime. We investigate the structural properties of skew cyclic codes over $R$ through a decomposition theorem. Furthermore, we give a formula for the number of skew cyclic codes of length $n$ over $R.$

Efficient diagonalization of the sparse matrices produced within the framework of the UK R-matrix molecular codes

Science.gov (United States)

Galiatsatos, P. G.; Tennyson, J.

2012-11-01

The most time consuming step within the framework of the UK R-matrix molecular codes is that of the diagonalization of the inner region Hamiltonian matrix (IRHM). Here we present the method that we follow to speed up this step. We use shared memory machines (SMM), distributed memory machines (DMM), the OpenMP directive based parallel language, the MPI function based parallel language, the sparse matrix diagonalizers ARPACK and PARPACK, a variation for real symmetric matrices of the official coordinate sparse matrix format and finally a parallel sparse matrix-vector product (PSMV). The efficient application of the previous techniques rely on two important facts: the sparsity of the matrix is large enough (more than 98%) and in order to get back converged results we need a small only part of the matrix spectrum.

The mechanism of long non-coding RNA MEG3 for neurons apoptosis caused by hypoxia: mediated by miR-181b-12/15-LOX signaling pathway

Directory of Open Access Journals (Sweden)

Xiaomin Liu

2016-09-01

Full Text Available Objective: lncRNAs are recently thought to play a significant role in cellular homeostasis during pathological process of diseases by competing inhibiting miRNA function. The aim of present study was to assess the function of long non-coding RNA (lncRNA MEG3 and its functional interaction with microRNA-181b in cerebral ischemic infarct of mice and hypoxia-induced neurons apoptosis. Methods: To address this question, we performed the experiments with in vivo middle cerebral artery occlusion (MCAO mice model and in vitro oxygen-glucose deprivation (OGD-cultured neuronal HT22 cell line. Relative expression of MEG3, miR-181b and 12/15-LOX (lipoxygenase mRNA was determined using quantitative RT-PCR. Western blot was used to evaluate 12/15-LOX protein expression. TUNEL assay was performed to assess cell apoptosis.Results: In both MCAO mice and OGD-cultured HT22 cell, ischemia or hypoxia treatment results in a time-dependent increase in MEG3 and 12/15-LOX expression and decrease in miR-181b expression. Knockdown of MEG3 contributes to attenuation of hypoxia-induced apoptosis of HT22 cell. Also, expression level of MEG3 negatively correlated with miR-181b expression and positively correlated with 12/15-LOX expression. In contrary to MEG3, miR-181b overexpression attenuated hypoxia-induced HT22 cell apoptosis, as well as suppressed hypoxia-induced increase in 12/15-LOX expression. By luciferase reporter assay, we concluded that miR-181b directly binds to 12/15-LOX 3’-UTR, thereby negatively regulates 12/15-LOX expression. Conclusion: Our data suggested that long non-coding RNA MEG3 functions as a competing endogenous RNA for miR-181b to regulate 12/15-LOX expression in middle cerebral artery occlusion-induced ischemic infarct of brain nerve cells.

DNA methylation of miRNA coding sequences putatively associated with childhood obesity.

Science.gov (United States)

Mansego, M L; Garcia-Lacarte, M; Milagro, F I; Marti, A; Martinez, J A

2017-02-01

Epigenetic mechanisms may be involved in obesity onset and its consequences. The aim of the present study was to evaluate whether DNA methylation status in microRNA (miRNA) coding regions is associated with childhood obesity. DNA isolated from white blood cells of 24 children (identification sample: 12 obese and 12 non-obese) from the Grupo Navarro de Obesidad Infantil study was hybridized in a 450 K methylation microarray. Several CpGs whose DNA methylation levels were statistically different between obese and non-obese were validated by MassArray® in 95 children (validation sample) from the same study. Microarray analysis identified 16 differentially methylated CpGs between both groups (6 hypermethylated and 10 hypomethylated). DNA methylation levels in miR-1203, miR-412 and miR-216A coding regions significantly correlated with body mass index standard deviation score (BMI-SDS) and explained up to 40% of the variation of BMI-SDS. The network analysis identified 19 well-defined obesity-relevant biological pathways from the KEGG database. MassArray® validation identified three regions located in or near miR-1203, miR-412 and miR-216A coding regions differentially methylated between obese and non-obese children. The current work identified three CpG sites located in coding regions of three miRNAs (miR-1203, miR-412 and miR-216A) that were differentially methylated between obese and non-obese children, suggesting a role of miRNA epigenetic regulation in childhood obesity. © 2016 World Obesity Federation.

Long non-coding RNA MALAT1 acts as a competing endogenous RNA to promote malignant melanoma growth and metastasis by sponging miR-22.

Science.gov (United States)

Luan, Wenkang; Li, Lubo; Shi, Yan; Bu, Xuefeng; Xia, Yun; Wang, Jinlong; Djangmah, Henry Siaw; Liu, Xiaohui; You, Yongping; Xu, Bin

2016-09-27

Long non-coding RNAs (lncRNAs) are involved in tumorigenesis. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), an lncRNAs, is associated with the growth and metastasis of many human tumors, but its biological roles in malignant melanoma remain unclear. In this study, the aberrant up-regulation of MALAT1 was detected in melanoma. We determined that MALAT1 promotes melanoma cells proliferation, invasion and migration by sponging miR-22. MiR-22 was decreased and acted as a tumor suppressor in melanoma, and MMP14 and Snail were the functional targets of miR-22. Furthermore, MALAT1 could modulate MMP14 and Snail by operating as a competing endogenous RNA (ceRNA) for miR-22. The effects of MALAT1 in malignant melanoma is verified using a xenograft model. This finding elucidates a new mechanism for MALAT1 in melanoma development and provides a potential target for melanoma therapeutic intervention.

The Aster code

International Nuclear Information System (INIS)

Delbecq, J.M.

1999-01-01

The Aster code is a 2D or 3D finite-element calculation code for structures developed by the R and D direction of Electricite de France (EdF). This dossier presents a complete overview of the characteristics and uses of the Aster code: introduction of version 4; the context of Aster (organisation of the code development, versions, systems and interfaces, development tools, quality assurance, independent validation); static mechanics (linear thermo-elasticity, Euler buckling, cables, Zarka-Casier method); non-linear mechanics (materials behaviour, big deformations, specific loads, unloading and loss of load proportionality indicators, global algorithm, contact and friction); rupture mechanics (G energy restitution level, restitution level in thermo-elasto-plasticity, 3D local energy restitution level, KI and KII stress intensity factors, calculation of limit loads for structures), specific treatments (fatigue, rupture, wear, error estimation); meshes and models (mesh generation, modeling, loads and boundary conditions, links between different modeling processes, resolution of linear systems, display of results etc..); vibration mechanics (modal and harmonic analysis, dynamics with shocks, direct transient dynamics, seismic analysis and aleatory dynamics, non-linear dynamics, dynamical sub-structuring); fluid-structure interactions (internal acoustics, mass, rigidity and damping); linear and non-linear thermal analysis; steels and metal industry (structure transformations); coupled problems (internal chaining, internal thermo-hydro-mechanical coupling, chaining with other codes); products and services. (J.S.)

Linear and nonlinear verification of gyrokinetic microstability codes

Science.gov (United States)

Bravenec, R. V.; Candy, J.; Barnes, M.; Holland, C.

2011-12-01

Verification of nonlinear microstability codes is a necessary step before comparisons or predictions of turbulent transport in toroidal devices can be justified. By verification we mean demonstrating that a code correctly solves the mathematical model upon which it is based. Some degree of verification can be accomplished indirectly from analytical instability threshold conditions, nonlinear saturation estimates, etc., for relatively simple plasmas. However, verification for experimentally relevant plasma conditions and physics is beyond the realm of analytical treatment and must rely on code-to-code comparisons, i.e., benchmarking. The premise is that the codes are verified for a given problem or set of parameters if they all agree within a specified tolerance. True verification requires comparisons for a number of plasma conditions, e.g., different devices, discharges, times, and radii. Running the codes and keeping track of linear and nonlinear inputs and results for all conditions could be prohibitive unless there was some degree of automation. We have written software to do just this and have formulated a metric for assessing agreement of nonlinear simulations. We present comparisons, both linear and nonlinear, between the gyrokinetic codes GYRO [J. Candy and R. E. Waltz, J. Comput. Phys. 186, 545 (2003)] and GS2 [W. Dorland, F. Jenko, M. Kotschenreuther, and B. N. Rogers, Phys. Rev. Lett. 85, 5579 (2000)]. We do so at the mid-radius for the same discharge as in earlier work [C. Holland, A. E. White, G. R. McKee, M. W. Shafer, J. Candy, R. E. Waltz, L. Schmitz, and G. R. Tynan, Phys. Plasmas 16, 052301 (2009)]. The comparisons include electromagnetic fluctuations, passing and trapped electrons, plasma shaping, one kinetic impurity, and finite Debye-length effects. Results neglecting and including electron collisions (Lorentz model) are presented. We find that the linear frequencies with or without collisions agree well between codes, as do the time averages of

State of art in FE-based fuel performance codes

International Nuclear Information System (INIS)

Kim, Hyo Chan; Yang, Yong Sik; Kim, Dae Ho; Bang, Je Geon; Kim, Sun Ki; Koo, Yang Hyun

2013-01-01

Fuel performance codes approximate this complex behavior using an axisymmetric, axially-stacked, one-dimensional radial representation to save computation cost. However, the need for improved modeling of PCMI and, particularly, the importance of multidimensional capability for accurate fuel performance simulation has been identified as safety margin decreases. Finite element (FE) method that is reliable and proven solution in mechanical field has been introduced into fuel performance codes for multidimensional analysis. The present state of the art in numerical simulation of FE-based fuel performance predominantly involves 2-D axisymmetric model and 3-D volumetric model. The FRAPCON and FRAPTRAN own 1.5-D and 2-D FE model to simulate PCMI and cladding ballooning. In 2-D simulation, the FALCON code, developed by EPRI, is a 2-D (R-Z and R-θ) fully thermal-mechanically coupled steady-state and transient FE-based fuel behavior code. The French codes TOUTATIS and ALCYONE which are 3-D, and typically used to investigate localized behavior. In 2008, the Idaho National Laboratory (INL) has been developing multidimensional (2-D and 3-D) nuclear fuel performance code called BISON. In this paper, the current state of FE-based fuel performance code and their models are presented. Based on investigation into the codes, requirements and direction of development for new FE-based fuel performance code can be discussed. Based on comparison of models in FE-based fuel performance code, status of art in the codes can be discussed. A new FE-based fuel performance code should include typical pellet and cladding models which all codes own. In particular, specified pellet and cladding model such as gaseous swelling and high burnup structure (HBS) model should be developed to improve accuracy of code as well as consider AC condition. To reduce computation cost, the approximated gap and the optimized contact model should be also developed

On the equivalence of cyclic and quasi-cyclic codes over finite fields

Directory of Open Access Journals (Sweden)

Kenza Guenda

2017-07-01

Full Text Available This paper studies the equivalence problem for cyclic codes of length $p^r$ and quasi-cyclic codes of length $p^rl$. In particular, we generalize the results of Huffman, Job, and Pless (J. Combin. Theory. A, 62, 183--215, 1993, who considered the special case $p^2$. This is achieved by explicitly giving the permutations by which two cyclic codes of prime power length are equivalent. This allows us to obtain an algorithm which solves the problem of equivalency for cyclic codes of length $p^r$ in polynomial time. Further, we characterize the set by which two quasi-cyclic codes of length $p^rl$ can be equivalent, and prove that the affine group is one of its subsets.

Research on Primary Shielding Calculation Source Generation Codes

Science.gov (United States)

Zheng, Zheng; Mei, Qiliang; Li, Hui; Shangguan, Danhua; Zhang, Guangchun

2017-09-01

Primary Shielding Calculation (PSC) plays an important role in reactor shielding design and analysis. In order to facilitate PSC, a source generation code is developed to generate cumulative distribution functions (CDF) for the source particle sample code of the J Monte Carlo Transport (JMCT) code, and a source particle sample code is deveoped to sample source particle directions, types, coordinates, energy and weights from the CDFs. A source generation code is developed to transform three dimensional (3D) power distributions in xyz geometry to source distributions in r θ z geometry for the J Discrete Ordinate Transport (JSNT) code. Validation on PSC model of Qinshan No.1 nuclear power plant (NPP), CAP1400 and CAP1700 reactors are performed. Numerical results show that the theoretical model and the codes are both correct.

R data analysis without programming

CERN Document Server

Gerbing, David W

2013-01-01

This book prepares readers to analyze data and interpret statistical results using R more quickly than other texts. R is a challenging program to learn because code must be created to get started. To alleviate that challenge, Professor Gerbing developed lessR. LessR extensions remove the need to program. By introducing R through less R, readers learn how to organize data for analysis, read the data into R, and produce output without performing numerous functions and programming exercises first. With lessR, readers can select the necessary procedure and change the relevant variables without pro

HTR core physics and transient analyses by the Panthermix code system

International Nuclear Information System (INIS)

Haas, J.B.M. de; Kuijper, J.C.; Oppe, J.

2005-01-01

At NRG Petten, core physics analyses on High Temperature gas-cooled Reactors (HTRs) are mainly performed by means of the PANTHERMIX code system. Since some years NRG is developing the HTR reactor physics code system WIMS/PANTHERMIX, based on the lattice code WIMS (Serco Assurance, UK), the 3-dimensional steady-state and transient core physics code PANTHER (British Energy, UK) and the 2-dimensional R-Z HTR thermal hydraulics code THERMIX-DIREKT (Research Centre FZJ Juelich, Germany). By means of the WIMS code nuclear data are being generated to suit the PANTHER code's neutronics. At NRG the PANTHER code has been interfaced with THERMIX-DIREKT to form PANTHERMIX, to enable core-follow/fuel management and transient analyses in a consistent manner on pebble bed type HTR systems. Also provisions have been made to simulate the flow of pebbles through the core of a pebble bed HTR, according to a given (R-Z) flow pattern. As examples of the versatility of the PANTHERMIX code system, calculations are presented on the PBMR, the South African pebble bed reactor design, to show the transient capabilities, and on a plutonium burning MEDUL-reactor, to demonstrate the core-follow/fuel management capabilities. For the investigated cases a good agreement is observed with the results of other HTR core physics codes

Cassandre : a two-dimensional multigroup diffusion code for reactor transient analysis

International Nuclear Information System (INIS)

Arien, B.; Daniels, J.

1986-12-01

CASSANDRE is a two-dimensional (x-y or r-z) finite element neutronics code with thermohydraulics feedback for reactor dynamics prior to the disassembly phase. It uses the multigroup neutron diffusion theory. Its main characteristics are the use of a generalized quasistatic model, the use of a flexible multigroup point-kinetics algorithm allowing for spectral matching and the use of a finite element description. The code was conceived in order to be coupled with any thermohydraulics module, although thermohydraulics feedback is only considered in r-z geometry. In steady state criticality search is possible either by control rod insertion or by homogeneous poisoning of the coolant. This report describes the main characterstics of the code structure and provides all the information needed to use the code. (Author)

Development of LEAP-JET code for sodium-water reaction analysis. Validation by sodium-water reaction tests (SWAT-1R)

International Nuclear Information System (INIS)

Seino, Hiroshi; Hamada, Hirotsugu

2004-03-01

The sodium-water reaction event in an FBR steam generator (SG) has influence on the safety, economical efficiency, etc. of the plant, so that the selection of design base leak (DBL) of the SG is considered as one of the important matters. The clarification of the sodium-water reaction phenomenon and the development of an analysis model are necessary to estimate the sodium-water reaction event with high accuracy and rationality in selecting the DBL. The reaction jet model is pointed out as a part of the necessary improvements to evaluate the overheating tube rupture of large SGs, since the behavior of overheating tube rupture is largely affected by the reaction jet conditions outside the tube. Therefore, LEAP-JET has been developed as an analysis code for the simulation of sodium-water reactions. This document shows the validation of the LEAP-JET code by the Sodium-Water Reaction Test (SWAT-1R). The following results have been obtained: (1) The reaction rate constant, K, is estimated at between 0.001≤K≤0.1 from the LEAP-JET analysis of the SWAT-1R data. (2) The analytical results on the high-temperature region and the behaviors of reaction consumption (Na, H 2 O) and products (H 2 , NaOH, Na 2 O) are considered to be physically reasonable. (3) The LEAP-JET analysis shows the tendency of overestimation in the maximum temperature and temperature distribution of the reaction jet. (4) In the LEAP-JET analysis, the numerical calculation becomes unstably, especially in the mesh containing quite small sodium mass. Therefore, it is necessary to modify the computational algorism to stabilize it and obtain the optimum value of K in sodium-water reactions. (author)

Criticality benchmarks for COG: A new point-wise Monte Carlo code

International Nuclear Information System (INIS)

Alesso, H.P.; Pearson, J.; Choi, J.S.

1989-01-01

COG is a new point-wise Monte Carlo code being developed and tested at LLNL for the Cray computer. It solves the Boltzmann equation for the transport of neutrons, photons, and (in future versions) charged particles. Techniques included in the code for modifying the random walk of particles make COG most suitable for solving deep-penetration (shielding) problems. However, its point-wise cross-sections also make it effective for a wide variety of criticality problems. COG has some similarities to a number of other computer codes used in the shielding and criticality community. These include the Lawrence Livermore National Laboratory (LLNL) codes TART and ALICE, the Los Alamos National Laboratory code MCNP, the Oak Ridge National Laboratory codes 05R, 06R, KENO, and MORSE, the SACLAY code TRIPOLI, and the MAGI code SAM. Each code is a little different in its geometry input and its random-walk modification options. Validating COG consists in part of running benchmark calculations against critical experiments as well as other codes. The objective of this paper is to present calculational results of a variety of critical benchmark experiments using COG, and to present the resulting code bias. Numerous benchmark calculations have been completed for a wide variety of critical experiments which generally involve both simple and complex physical problems. The COG results, which they report in this paper, have been excellent

Design of Packet-Based Block Codes with Shift Operators

Directory of Open Access Journals (Sweden)

Jacek Ilow

2010-01-01

Full Text Available This paper introduces packet-oriented block codes for the recovery of lost packets and the correction of an erroneous single packet. Specifically, a family of systematic codes is proposed, based on a Vandermonde matrix applied to a group of k information packets to construct r redundant packets, where the elements of the Vandermonde matrix are bit-level right arithmetic shift operators. The code design is applicable to packets of any size, provided that the packets within a block of k information packets are of uniform length. In order to decrease the overhead associated with packet padding using shift operators, non-Vandermonde matrices are also proposed for designing packet-oriented block codes. An efficient matrix inversion procedure for the off-line design of the decoding algorithm is presented to recover lost packets. The error correction capability of the design is investigated as well. The decoding algorithm, based on syndrome decoding, to correct a single erroneous packet in a group of n=k+r received packets is presented. The paper is equipped with examples of codes using different parameters. The code designs and their performance are tested using Monte Carlo simulations; the results obtained exhibit good agreement with the corresponding theoretical results.

CASC2/miR-24/miR-221 modulates the TRAIL resistance of hepatocellular carcinoma cell through caspase-8/caspase-3.

Science.gov (United States)

Jin, Xiaoxin; Cai, Lifeng; Wang, Changfa; Deng, Xiaofeng; Yi, Shengen; Lei, Zhao; Xiao, Qiangsheng; Xu, Hongbo; Luo, Hongwu; Sun, Jichun

2018-02-23

Hepatocellular carcinoma is one of the most common solid tumors in the digestive system. The prognosis of patients with hepatocellular carcinoma is still poor due to the acquisition of multi-drug resistance. TNF Related Apoptosis Inducing Ligand (TRAIL), an attractive anticancer agent, exerts its effect of selectively inducing apoptosis in tumor cells through death receptors and the formation of the downstream death-inducing signaling complex, which activates apical caspases 3/8 and leads to apoptosis. However, hepatocellular carcinoma cells are resistant to TRAIL. Non-coding RNAs, including long non-coding RNAs (lncRNAs) and miRNAs have been regarded as major regulators of normal development and diseases, including cancers. Moreover, lncRNAs and miRNAs have been reported to be associated with multi-drug resistance. In the present study, we investigated the mechanism by which TRAIL resistance of hepatocellular carcinoma is affected from the view of non-coding RNA regulation. We selected and validated candidate miRNAs, miR-24 and miR-221, that regulated caspase 3/8 expression through direct targeting, and thereby affecting TRAIL-induced tumor cell apoptosis TRAIL resistance of hepatocellular carcinoma. In addition, we revealed that CASC2, a well-established tumor suppressive long non-coding RNA, could serve as a "Sponge" of miR-24 and miR-221, thus modulating TRAIL-induced tumor cell apoptosis TRAIL resistance of hepatocellular carcinoma. Taken together, we demonstrated a CASC2/miR-24/miR-221 axis, which can affect the TRAIL resistance of hepatocellular carcinoma through regulating caspase 3/8; through acting as a "Sponge" of miR-24 and miR-221, CASC2 may contribute to improving hepatocellular carcinoma TRAIL resistance, and finally promoting the treatment efficiency of TRAIL-based therapies.

HTR core physics and transient analyses by the Panthermix code system

Energy Technology Data Exchange (ETDEWEB)

Haas, J.B.M. de; Kuijper, J.C.; Oppe, J. [NRG - Fuels, Actinides and Isotopes group, Petten (Netherlands)

2005-07-01

At NRG Petten, core physics analyses on High Temperature gas-cooled Reactors (HTRs) are mainly performed by means of the PANTHERMIX code system. Since some years NRG is developing the HTR reactor physics code system WIMS/PANTHERMIX, based on the lattice code WIMS (Serco Assurance, UK), the 3-dimensional steady-state and transient core physics code PANTHER (British Energy, UK) and the 2-dimensional R-Z HTR thermal hydraulics code THERMIX-DIREKT (Research Centre FZJ Juelich, Germany). By means of the WIMS code nuclear data are being generated to suit the PANTHER code's neutronics. At NRG the PANTHER code has been interfaced with THERMIX-DIREKT to form PANTHERMIX, to enable core-follow/fuel management and transient analyses in a consistent manner on pebble bed type HTR systems. Also provisions have been made to simulate the flow of pebbles through the core of a pebble bed HTR, according to a given (R-Z) flow pattern. As examples of the versatility of the PANTHERMIX code system, calculations are presented on the PBMR, the South African pebble bed reactor design, to show the transient capabilities, and on a plutonium burning MEDUL-reactor, to demonstrate the core-follow/fuel management capabilities. For the investigated cases a good agreement is observed with the results of other HTR core physics codes.

Network Coding for Wireless Cooperative Networks

DEFF Research Database (Denmark)

Khamfroush, Hana; Roetter, Daniel Enrique Lucani; Barros, João

2014-01-01

We consider the problem of finding an optimal packet transmission policy that minimizes the total cost of transmitting M data packets from a source S to two receivers R1,R2 over half-duplex, erasure channels. The source can either broadcast random linear network coding (RLNC) packets to the recei......We consider the problem of finding an optimal packet transmission policy that minimizes the total cost of transmitting M data packets from a source S to two receivers R1,R2 over half-duplex, erasure channels. The source can either broadcast random linear network coding (RLNC) packets...... to the receivers or transmit using unicast sessions at each time slot. We assume that the receivers can share their knowledge with each other by sending RLNC packets using unicast transmissions. We model this problem by using a Markov Decision Process (MDP), where the actions include the source of and type...... of transmission to be used in a given time slot given perfect knowledge of the system state. We study the distribution of actions selected by the MDP in terms of the knowledge at the receivers, the channel erasure probabilities, and the ratio between the cost of broadcast and unicast. This allowed us to learn...

Further results on binary convolutional codes with an optimum distance profile

DEFF Research Database (Denmark)

Johannesson, Rolf; Paaske, Erik

1978-01-01

Fixed binary convolutional codes are considered which are simultaneously optimal or near-optimal according to three criteria: namely, distance profiled, free distanced_{ infty}, and minimum number of weightd_{infty}paths. It is shown how the optimum distance profile criterion can be used to limit...... codes. As a counterpart to quick-look-in (QLI) codes which are not "transparent," we introduce rateR = 1/2easy-look-in-transparent (ELIT) codes with a feedforward inverse(1 + D,D). In general, ELIT codes haved_{infty}superior to that of QLI codes....

Efficiency of rate and latency coding with respect to metabolic cost and time

Czech Academy of Sciences Publication Activity Database

Leváková, Marie

2017-01-01

Roč. 161, Nov 2017 (2017), s. 31-40 ISSN 0303-2647 R&D Projects: GA ČR(CZ) GA15-08066S Institutional support: RVO:67985823 Keywords : rate coding * temporal coding * metabolic cost * Fisher information Subject RIV: BD - Theory of Information OBOR OECD: Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology Impact factor: 1.652, year: 2016

Reliability of Calderbank-Shor-Steane codes and security of quantum key distribution

International Nuclear Information System (INIS)

Hamada, Mitsuru

2004-01-01

After Mayers (1996 Advances in Cryptography: Proc. Crypto'96 pp 343-57; 2001 J. Assoc. Comput. Mach. 48 351-406) gave a proof of the security of the Bennett-Brassard (1984 Proc. IEEE Int. Conf. on Computers, Systems and Signal Processing (Bangalore, India) pp 175-9) (BB84) quantum key distribution protocol, Shor and Preskill (2000 Phys. Rev. Lett. 85 441-4) made a remarkable observation that a Calderbank-Shor-Steane (CSS) code had been implicitly used in the BB84 protocol, and suggested its security could be proved by bounding the fidelity, say F n , of the incorporated CSS code of length n in the form 1-F n ≤ exp[-nE + o(n)] for some positive number E. This work presents such a number E = E(R) as a function of the rate of codes R, and a threshold R 0 such that E(R) > 0 whenever R 0 , which is larger than the achievable rate based on the Gilbert-Varshamov bound that is essentially given by Shor and Preskill. The codes in the present work are robust against fluctuations of channel parameters, which fact is needed to establish the security rigorously and was not proved for rates above the Gilbert-Varshamov rate before in the literature. As a byproduct, the security of a modified BB84 protocol against any joint (coherent) attacks is proved quantitatively

Running R Statistical Computing Environment Software on the Peregrine

Science.gov (United States)

") print(p) dev.off() Parallel Programming in R Programming in R on Peregrine has two distinct parallel processing. R code, like many programming languages, is typically written and executed serially highlight interesting packages, problems, and share experiences related to R programming. Contact Daniel

Long non-coding RNA TUG1 promotes progression of oral squamous cell carcinoma through upregulating FMNL2 by sponging miR-219.

Science.gov (United States)

Yan, Guangqi; Wang, Xue; Yang, Mingliang; Lu, Li; Zhou, Qing

2017-01-01

Oral squamous cell carcinoma (OSCC) is a prevalent oral disease with a high morbidity and mortality rate. Several long non-coding RNAs (lncRNAs) were identified as important regulators of carcinogenesis. However, the pathogenic implications of TUG1 in OSCC are still unclear. In the present study, the expression of TUG1 was increased in OSCC cells. Knockdown of TUG1 inhibited cell proliferation, migration, and invasion, and induced cell cycle arrest at G0/G1 phase, whereas overexpression of TUG1 exerted the opposite effect on OSCC cells. A reciprocal repressive interaction between TUG1 and miR-219 was found, and miR-219 inhibition abolished the tumor-suppressive effect of TUG1 knockdown on cell growth and motility. Furthermore, bioinformatics analysis and luciferase reporter assay showed that FMNL2 was a direct target of miR-219. Restoration of FMNL2 abrogated the miR-219-induced inhibition of cell proliferation, cell cycle progression, migration, and invasion. Besides, overexpression of TUG1 promoted tumor growth and metastasis in vivo . Clinically, the expression of TUG1 and FMNL2 were increased, but miR-219 was decreased in primary tumors compared to non-tumor tissues. Both the upregulated TUG1, and FMNL2 and the downregulated miR-219 was associated with advanced stage of OSCC and poor overall survival. Notably, multivariate analyses confirmed that FMNL2 was an independent risk factor for OSCC. In conclusion, our data revealed that TUG1 confers oncogenic function in OSCC and TUG1/miR-219/FMNL2 axis may be a novel therapeutic strategy in this disease.

Rapport: Coding Class - Dokumentation og evaluering

DEFF Research Database (Denmark)

Hansbøl, Mikala; Ejsing-Duun, Stine

2017-01-01

Denne rapport rummer evaluering og dokumentation af Coding Class projektet . Coding Class projektet blev igangsat i skoleåret 2016/2017 af IT-Branchen i samarbejde med en række medlemsvirksomheder, Københavns kommune, Vejle Kommune, Styrelsen for IT- og Læring (STIL) og den frivillige forening...... Coding Pirates . Rapporten er forfattet af Docent i digitale læringsressourcer og faglig leder af forsknings- og udviklingsmiljøet Digitalisering i Skolen (DiS), Mikala Hansbøl, fra Institut for Skole og Læring ved professionshøjskolen Metropol; og Lektor i læringsteknologi, interaktionsdesign, design...... tænkning og design-pædagogik, Stine Ejsing-Duun fra Forskningslab: It og Læringsdesign (ILD-LAB) ved Institut for Kommunikation ved Aalborg Universitet i København. Vi har fulgt og gennemført evaluering og dokumentation af Coding Class projektet i perioden november 2016 til maj 2017...

Riemann-Roch Spaces and Linear Network Codes

DEFF Research Database (Denmark)

Hansen, Johan P.

We construct linear network codes utilizing algebraic curves over finite fields and certain associated Riemann-Roch spaces and present methods to obtain their parameters. In particular we treat the Hermitian curve and the curves associated with the Suzuki and Ree groups all having the maximal...... number of points for curves of their respective genera. Linear network coding transmits information in terms of a basis of a vector space and the information is received as a basis of a possibly altered vector space. Ralf Koetter and Frank R. Kschischang %\\cite{DBLP:journals/tit/KoetterK08} introduced...... in the above metric making them suitable for linear network coding....

Nonuniform code concatenation for universal fault-tolerant quantum computing

Science.gov (United States)

Nikahd, Eesa; Sedighi, Mehdi; Saheb Zamani, Morteza

2017-09-01

Using transversal gates is a straightforward and efficient technique for fault-tolerant quantum computing. Since transversal gates alone cannot be computationally universal, they must be combined with other approaches such as magic state distillation, code switching, or code concatenation to achieve universality. In this paper we propose an alternative approach for universal fault-tolerant quantum computing, mainly based on the code concatenation approach proposed in [T. Jochym-O'Connor and R. Laflamme, Phys. Rev. Lett. 112, 010505 (2014), 10.1103/PhysRevLett.112.010505], but in a nonuniform fashion. The proposed approach is described based on nonuniform concatenation of the 7-qubit Steane code with the 15-qubit Reed-Muller code, as well as the 5-qubit code with the 15-qubit Reed-Muller code, which lead to two 49-qubit and 47-qubit codes, respectively. These codes can correct any arbitrary single physical error with the ability to perform a universal set of fault-tolerant gates, without using magic state distillation.

The Long Non-Coding RNA XIST Controls Non-Small Cell Lung Cancer Proliferation and Invasion by Modulating miR-186-5p

Directory of Open Access Journals (Sweden)

Haoyou Wang

2017-04-01

Full Text Available Background/Aims: Long non-coding RNAs (lncRNAs are key players in the development and progression of human cancers. The lncRNA XIST (X-inactive specific transcript has been shown to be upregulated in human non-small cell lung cancer (NSCLC; however, its role and molecular mechanisms in NSCLC cell progression remain unclear. Methods: qRT-PCR was conducted to assess the expression of XIST and miR-186. Cell proliferation was detected using MTT assay. Cell invasion and migration were evaluated using transwell assay. Cell cycle distribution and apoptosis rates were analyzed by flow cytometry. Luciferase reporter assay was used to identify the direct regulation of XIST and miR-186. A RNA immunoprecipitation was used to analyze whether XIST was associated with the RNA-induced silencing complex (RISC. Results: We confirmed that XIST was upregulated in NSCLC cell lines and tissues. Functionally, XIST knockdown inhibited cancer cell proliferation and invasion, and induced apoptosis in vitro, and suppressed subcutaneous tumor growth in vivo. Mechanistic investigations revealed a reciprocal repressive interaction between XIST and miR-186-5p. Furthermore, we showed that miR-186-5p has a binding site for XIST. Our data also indicated that XIST and miR-186-5p are likely in the same RNA induced silencing complex. Conclusion: Together, our data revealed that XIST knockdown confers suppressive function in NSCLC and XIST may be a novel therapeutic marker in this disease.

Optimal codes as Tanner codes with cyclic component codes

DEFF Research Database (Denmark)

Høholdt, Tom; Pinero, Fernando; Zeng, Peng

2014-01-01

In this article we study a class of graph codes with cyclic code component codes as affine variety codes. Within this class of Tanner codes we find some optimal binary codes. We use a particular subgraph of the point-line incidence plane of A(2,q) as the Tanner graph, and we are able to describe ...

Specific structural probing of plasmid-coded ribosomal RNAs from Escherichia coli

DEFF Research Database (Denmark)

Aagaard, C; Rosendahl, G; Dam, M

1991-01-01

The preferred method for construction and in vivo expression of mutagenised Escherichia coli ribosomal RNAs (rRNAs) is via high copy number plasmids. Transcription of wild-type rRNA from the seven chromosomal rrn operons in strains harbouring plasmid-coded mutant rRNAs leads to a heterogeneous...

miR482 and Its Isoforms in Plants

Directory of Open Access Journals (Sweden)

Abdil Hakan EREN

2016-09-01

Full Text Available In plants, miR482 family members are generally 22-nucleotide long, distinguishing from other microRNA (miRNA families by their extraordinary and diverse sequence structures. Studies showed that miRNA482 is related to NBLRR (Nucleotide binding-site leucine-rich repeat genes conferring resistance to disease in plants. There are different coded NB-LRR genes which are considered as the part immune response assisting the recognition of pathogens in plant genomes. NB-LRR proteins are mostly related to effector – triggering immune system against pathogens. The main immune receptors in plants are PRR (Pattern recoginition receptor and R (Resistance proteins. R proteins code for immune system proteins by NB-LRR activity. miR482, miR1448, slmiR2118 and ath-miR472 are disease resistance related miRNAs. In several studies, miR482 was found to be a homolog of miR1448 and phylogenetic analyses showed that miR1448 is formed by tandem duplication of miR482. While suppression of miR482 results in plant susceptibility to pathogens, miR482 was considered to play role in nodulation and mycorrhizal processes of soya roots. Increasing evidences exhibit that miR482 is critical in disease resistance against pathogen attacks.

CFD codes and the Onsager relations

International Nuclear Information System (INIS)

Makai, M.

2008-01-01

In the last decade, papers appeared in the literature discussing a shortcoming of the basic equations of hydrodynamics: the Navier-Stokes equations do not meet the Onsager symmetry relations. Recently R. Streater wrote about the topic. The basic problem is that the solution to the Boltzmann equation f(r,v,t) depends on seven variable, nevertheless the solution of the Navier-Stokes equation yields T(r,t),v(r,t) and ?(r,t)-the temperature, velocity and density distribution, altogether ?ve functions. Clearly, the solution class of the Boltzmann equation is a broader class than the solution class of the Navier-Stokes equation. What is the importance of that question? Are the results of CFD codes questionable ones or, the contradiction can be resolved by some ignored terms of second order? (Author)

Biocomputational prediction of small non-coding RNAs in Streptomyces

Czech Academy of Sciences Publication Activity Database

Pánek, Josef; Bobek, Jan; Mikulík, Karel; Basler, Marek; Vohradský, Jiří

2008-01-01

Roč. 9, č. 217 (2008), s. 1-14 ISSN 1471-2164 R&D Projects: GA ČR GP204/07/P361; GA ČR GA203/05/0106; GA ČR GA310/07/1009 Grant - others:XE(XE) EC Integrated Project ActinoGEN, LSHM-CT-2004-005224. Institutional research plan: CEZ:AV0Z50200510 Keywords : non-coding RNA * streptomyces * biocomputational prediction Subject RIV: IN - Informatics, Computer Science Impact factor: 3.926, year: 2008

R3-R4 deletion in the PRNP gene is associated with Creutzfeldt-Jakob disease (CJD)

Energy Technology Data Exchange (ETDEWEB)

Cervenakova, L.; Brown, P.; Nagle, J. [and others

1994-09-01

There are conflicting reports on the association of deletions in the PRNP gene on chromosome 20 with CJD, a rapidly progressive fatal spongiform encephalopathy. We accumulated data suggesting that a deletion of R3-R4 type (parts of the third and fourth repeats are deleted from the area of four repeating 24 bp sequences in the 5{prime} region of the gene) is causing CJD. Screening of 129 unaffected control individuals demonstrated presence of a deletion of R2 type in four (1.55% of the studied chromosomes), but none of them had the R3-R4 type. Of 181 screened patients with spongiform encephalopathies, two had a deletion of R3-R4 type with no other mutations in the coding sequence. Both patients had a classical rapidly progressive dementing disease and diffuse spongiform degeneration, and both cases were apparently sporadic. The same R3-R4 type of deletion was detected in three additional neuropathologically confirmed spongiform encephalopathy patients, of which two had other known pathogenic mutations in the PRNP gene: at codon 178 on the methionine allele exhibiting the phenotype of fatal familial insomnia, and codon 200 causing CJD with severe dementia; the third was a patient with iatrogenic CJD who developed the disease after treatment with growth hormone extracted from cadaveric human pituitary glands. In all cases the deletion coincided with a variant sequence at position 129 coding for methionine.

Widening the Scope of R-matrix Methods

Energy Technology Data Exchange (ETDEWEB)

Thompson, Ian J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Dimitriou, Paraskevi [IAEA, Vienna (Austria); DeBoer, Richard J. [Nieuwland Science Hall, Notre Dame, IN (United States); Kunieda, Satoshi [Nuclear Data Center (JAEA), Tokai (Japan); Paris, Mark [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Thompson, Ian [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Trkov, Andrej [IAEA, Vienna (Austria)

2016-03-01

A Consultant’s Meeting was held at the IAEA Headquarters, from 7 to 9 December 2015, to discuss the status of R-matrix codes currently used in calculations of charged-particle induced reaction cross sections at low energies. The ultimate goal was to initiate an international effort, coordinated by the IAEA, to evaluate charged-particle induced reactions in the resolved-resonance region. Participants reviewed the capabilities of the codes, the different implementations of R-matrix theory and translatability of the R-matrix parameters, the evaluation methods and suitable data formats for broader dissemination. The details of the presentations and technical discussions, as well as the actions that were proposed to achieve the goal of the meeting are summarized in this report.

Interoperable domain-specific languages families for code generation

Czech Academy of Sciences Publication Activity Database

Malohlava, M.; Plášil, F.; Bureš, Tomáš; Hnětynka, P.

2013-01-01

Roč. 43, č. 5 (2013), s. 479-499 ISSN 0038-0644 R&D Projects: GA ČR GD201/09/H057 EU Projects: European Commission(XE) ASCENS 257414 Grant - others:GA AV ČR(CZ) GAP103/11/1489 Program:FP7 Institutional research plan: CEZ:AV0Z10300504 Keywords : code generation * domain specific languages * models reuse * extensible languages * specification * program synthesis Subject RIV: JC - Computer Hardware ; Software Impact factor: 1.148, year: 2013

Safety, codes and standards for hydrogen installations. Metrics development and benchmarking

Energy Technology Data Exchange (ETDEWEB)

Harris, Aaron P. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Dedrick, Daniel E. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); LaFleur, Angela Christine [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); San Marchi, Christopher W. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2014-04-01

Automakers and fuel providers have made public commitments to commercialize light duty fuel cell electric vehicles and fueling infrastructure in select US regions beginning in 2014. The development, implementation, and advancement of meaningful codes and standards is critical to enable the effective deployment of clean and efficient fuel cell and hydrogen solutions in the energy technology marketplace. Metrics pertaining to the development and implementation of safety knowledge, codes, and standards are important to communicate progress and inform future R&D investments. This document describes the development and benchmarking of metrics specific to the development of hydrogen specific codes relevant for hydrogen refueling stations. These metrics will be most useful as the hydrogen fuel market transitions from pre-commercial to early-commercial phases. The target regions in California will serve as benchmarking case studies to quantify the success of past investments in research and development supporting safety codes and standards R&D.

Monte-Carlo method - codes for the study of criticality problems (on IBM 7094); Methode de Monte- Carlo - codes pour l'etude des problemes de criticite (IBM 7094)

Energy Technology Data Exchange (ETDEWEB)

Moreau, J; Rabot, H; Robin, C [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1965-07-01

The two codes presented here allow to determine the multiplication constant of media containing fissionable materials under numerous and divided forms; they are based on the Monte-Carlo method. The first code apply to x, y, z, geometries. The volume to be studied ought to be divisible in parallelepipeds, the media within each parallelepiped being limited by non-secant surfaces. The second code is intended for r, 0, z geometries. The results include an analysis of collisions in each medium. Applications and examples with informations on time and accuracy are given. (authors) [French] Les deux codes presentes dans ce rapport permettent la determination des coefficients de multiplication de milieux contenant des matieres fissiles sous des formes tres variees et divisees, ils reposent sur la methode de Monte-Carlo. Le premier code s'applique aux geometries x, y, z, le volume a etudier doit pouvoir etre decompose en parallelepipedes, les milieux a l'interieur de chaque parallelepipede etant limites par des surfaces non secantes. Le deuxieme code s'applique aux geometries r, 0, z. Les resultats comportent une analyse des collisions dans chaque milieu. Des applications et des exemples avec les indications de temps et de precision sont fournis. (auteurs)

Long non-coding RNA FBXL19-AS1 plays oncogenic role in colorectal cancer by sponging miR-203

International Nuclear Information System (INIS)

Shen, Bo; Yuan, Yuan; Zhang, Yan; Yu, Shaorong; Peng, Wei; Huang, Xin'en; Feng, Jifeng

2017-01-01

Long non-coding RNAs (lncRNAs) have emerged as critical regulators of the progression of human cancers, including colorectal cancer (CRC). The study of genome-wide lncRNA expression patterns in metastatic CRC could provide novel mechanism underlying CRC carcinogenesis. In here, we determined the lncRNA expression profiles correlating to CRC with or without lymph node metastasis (LNM) based on microarray analysis. We found that 2439 lncRNAs and 1654 mRNAs were differentially expressed in metastatic CRC relative to primary CRC. Among these dysregulated lncRNAs, FBXL19-AS1 was the most significantly upregulated lncRNA in metastatic tumors. Functionally, knockdown of FBXL19-AS1 played tumor-suppressive effects by inhibiting cell proliferation, migration and invasion in vitro and tumor growth and metastasis in vivo. Overexpression of FBXL19-AS1 was markedly correlated with TNM stage and LNM in CRC. Bioinformatics analysis predicted that miR-203 was potentially targeted by FBXL19-AS1, which was confirmed by dual-luciferase reporter assay. Pearson's correlation analysis showed that miR-203 expression was negatively related to FBXL19-AS1 in tumor tissues. Finally, miR-203 inhibition abrogated the effect of FBXL19-AS1 knockdown on the proliferation and invasion of LoVo cells. Our results reveal the cancer-promoting effect of FBXL19-AS1, acting as a molecular sponge in negatively modulating miR-203, which might provide a new insight for understanding of CRC development. - Highlights: • LncRNA expression signature was different between metastatic and primary tumors. • Knockdown of FBXL19-AS1 inhibits proliferation, migration and invasion in vitro. • Knockdown of FBXL19-AS1 inhibits tumorigenesis and metastasis in vivo. • FBXL19-AS1 was upregulated in CRC tissues and related with lymph node metastasis. • FBXL19-AS1, acting as a molecular sponge in negatively regulating miR-203.

R&D for Safety Codes and Standards: Materials and Components Compatibility

Energy Technology Data Exchange (ETDEWEB)

Somerday, Brian P. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); LaFleur, Chris [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Marchi, Chris San [Sandia National Lab. (SNL-CA), Livermore, CA (United States)

2015-08-01

This project addresses the following technical barriers from the Safety, Codes and Standards section of the 2012 Fuel Cell Technologies Office Multi-Year Research, Development and Demonstration Plan (section 3.8): (A) Safety data and information: limited access and availability (F) Enabling national and international markets requires consistent RCS (G) Insufficient technical data to revise standards.

Long non-coding RNA NEAT1 facilitates pancreatic cancer progression through negative modulation of miR-506-3p

International Nuclear Information System (INIS)

Huang, Bo; Liu, Chuan; Wu, Qiong; Zhang, Jing; Min, Qinghua; Sheng, Tianle; Wang, Xiaozhong; Zou, Yeqing

2017-01-01

Recently, long non-coding RNAs (lncRNAs) have been shown to have critical regulatory roles in tumourigenesis. Increasing evidence has suggested that lncRNA NEAT1 has been implicated in various types of human cancer. However, the potential biological roles and regulatory mechanisms of NEAT1 in pancreatic cancer (PC) remains unclear. Here, we found that the expression level of NEAT1 was higher in PC tissues compared to the corresponding non-tumor tissues. Besides, our findings indicate that high NEAT1 expression level is closely correlated with tumor progression and poor survival in PC patients. Furthermore, we also found that knockdown of NEAT1 remarkably suppressed cell proliferation by inducing cell cycle arrest and apoptosis promotion in PC cells. Moreover, bioinformatics analysis and luciferase reporter assay revealed that NEAT1 directly bound to the miR-506-3p, which has been reported to act as a tumor suppressor in diverse cancers. Additionally, our results confirmed that the tumor-promoting effects of NEAT1 in PC cells is at least partly through negative modulation of miR-506-3p. Overall, our results suggested that NEAT1 functions as an oncogenic lncRNA in PC, which could be a novel diagnostic and therapeutic target for PC. - Highlights: • Upregulation of NEAT1 expression was significantly associated with the poor survival in PC patients. • Knockdown of NEAT1 can suppress PC cells growth by inducing cell cycle arrest and apoptosis promotion in vitro study. • NEAT1 functions as an oncogene in pancreatic cancer by acting as a competing endogenous RNA for miR-506-3p. • The tumor-suppressive effects of NEAT1 knockdown in PC cells was partially reversed by miR-506-3p inhibitor.

Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.

Science.gov (United States)

Manousaki, Despoina; Dudding, Tom; Haworth, Simon; Hsu, Yi-Hsiang; Liu, Ching-Ti; Medina-Gómez, Carolina; Voortman, Trudy; van der Velde, Nathalie; Melhus, Håkan; Robinson-Cohen, Cassianne; Cousminer, Diana L; Nethander, Maria; Vandenput, Liesbeth; Noordam, Raymond; Forgetta, Vincenzo; Greenwood, Celia M T; Biggs, Mary L; Psaty, Bruce M; Rotter, Jerome I; Zemel, Babette S; Mitchell, Jonathan A; Taylor, Bruce; Lorentzon, Mattias; Karlsson, Magnus; Jaddoe, Vincent V W; Tiemeier, Henning; Campos-Obando, Natalia; Franco, Oscar H; Utterlinden, Andre G; Broer, Linda; van Schoor, Natasja M; Ham, Annelies C; Ikram, M Arfan; Karasik, David; de Mutsert, Renée; Rosendaal, Frits R; den Heijer, Martin; Wang, Thomas J; Lind, Lars; Orwoll, Eric S; Mook-Kanamori, Dennis O; Michaëlsson, Karl; Kestenbaum, Bryan; Ohlsson, Claes; Mellström, Dan; de Groot, Lisette C P G M; Grant, Struan F A; Kiel, Douglas P; Zillikens, M Carola; Rivadeneira, Fernando; Sawcer, Stephen; Timpson, Nicholas J; Richards, J Brent

2017-08-03

Vitamin D insufficiency is common, correctable, and influenced by genetic factors, and it has been associated with risk of several diseases. We sought to identify low-frequency genetic variants that strongly increase the risk of vitamin D insufficiency and tested their effect on risk of multiple sclerosis, a disease influenced by low vitamin D concentrations. We used whole-genome sequencing data from 2,619 individuals through the UK10K program and deep-imputation data from 39,655 individuals genotyped genome-wide. Meta-analysis of the summary statistics from 19 cohorts identified in CYP2R1 the low-frequency (minor allele frequency = 2.5%) synonymous coding variant g.14900931G>A (p.Asp120Asp) (rs117913124[A]), which conferred a large effect on 25-hydroxyvitamin D (25OHD) levels (-0.43 SD of standardized natural log-transformed 25OHD per A allele; p value = 1.5 × 10 -88 ). The effect on 25OHD was four times larger and independent of the effect of a previously described common variant near CYP2R1. By analyzing 8,711 individuals, we showed that heterozygote carriers of this low-frequency variant have an increased risk of vitamin D insufficiency (odds ratio [OR] = 2.2, 95% confidence interval [CI] = 1.78-2.78, p = 1.26 × 10 -12 ). Individuals carrying one copy of this variant also had increased odds of multiple sclerosis (OR = 1.4, 95% CI = 1.19-1.64, p = 2.63 × 10 -5 ) in a sample of 5,927 case and 5,599 control subjects. In conclusion, we describe a low-frequency CYP2R1 coding variant that exerts the largest effect upon 25OHD levels identified to date in the general European population and implicates vitamin D in the etiology of multiple sclerosis. Copyright © 2017 American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

Current Status of the Elevated Temperature Structure Design Codes for VHTR

International Nuclear Information System (INIS)

Kim, Jong-Bum; Kim, Seok-Hoon; Park, Keun-Bae; Lee, Won-Jae

2006-01-01

An elevated temperature structure design and analysis is one of the key issues in the VHTR (Very High Temperature Reactor) project to achieve an economic production of hydrogen which will be an essential energy source for the near future. Since the operating temperature of a VHTR is above 850 .deg. C, the existing code and standards are insufficient for a high temperature structure design. Thus the issues concerning a material selection and behaviors are being studied for the main structural components of a VHTR in leading countries such as US, France, UK, and Japan. In this study, the current status of the ASME code, French RCC-MR, UK R5, and Japanese code were investigated and the necessary R and D items were discussed

Non-coding RNA in Deinococcus radiodurans

International Nuclear Information System (INIS)

Chen Zhongzhong; Wang Liangyan; Lin Jun; Tian Bing; Hua Yuejin

2006-01-01

Researches on DNA damage and repair pathways of Deinococcus radiodurans show its extreme resistance to ionizing radiation, ultraviolet radiation and reactive oxygen species. Non-coding (ncRNA) RNAs are involved in a variety of processes such as transcriptional regulations, RNA processing and modification, mRNA translation, protein transportation and stability. The conserved secondary structures of intergenic regions of Deinococcus radiodurans R1 were predicted using Stochastic Context Free Grammar (SCFG) scan strategy. Results showed that 28 ncRNA families were present in the non-coding regions of the genome of Deinococcus radiodurans R1. Among these families, IRE is the largest family, followed by Histone3, tRNA, SECIS. DicF, ctRNA-pGA1 and tmRNA are one discovered in bacteria. Results from the comparison with other organisms showed that these ncRNA can be applied to the study of biological function of Deinococcus radiodurans and supply reference for the further study of DNA damage and repair mechanisms of this bacterium. (authors)

Optimized reversible binary-coded decimal adders

DEFF Research Database (Denmark)

Thomsen, Michael Kirkedal; Glück, Robert

2008-01-01

Abstract Babu and Chowdhury [H.M.H. Babu, A.R. Chowdhury, Design of a compact reversible binary coded decimal adder circuit, Journal of Systems Architecture 52 (5) (2006) 272-282] recently proposed, in this journal, a reversible adder for binary-coded decimals. This paper corrects and optimizes...... their design. The optimized 1-decimal BCD full-adder, a 13 × 13 reversible logic circuit, is faster, and has lower circuit cost and less garbage bits. It can be used to build a fast reversible m-decimal BCD full-adder that has a delay of only m + 17 low-power reversible CMOS gates. For a 32-decimal (128-bit....... Keywords: Reversible logic circuit; Full-adder; Half-adder; Parallel adder; Binary-coded decimal; Application of reversible logic synthesis...

Naval Weapons Center Plume Radar Frequency Interference Code

Science.gov (United States)

1982-10-01

ppm sodium. Both equilibrium and finite rate chemistry during the expansion from the chamber were tried as initial conditions for the plume. In...was too large. The difference between the.e two sets of initial conditions diminished downstream as the chemistry in the plume mixing region began to...Rerkirre Arvliral I Comirlnrnde!- ir.C h ic 1. tVS. Pacific Hice ((Code 3251 1 Corimu tinde r. ’n, r-d I leer. Pearl I atar I Coimniaide r. Sevent

Upregulation of long non-coding RNA TUG1 promotes bladder cancer cell 5 proliferation, migration and invasion by inhibiting miR-29c.

Science.gov (United States)

Guo, Peng; Zhang, Guohui; Meng, Jialin; He, Qian; Li, Zhihui; Guan, Yawei

2018-01-10

Bladder cancer (BC) is one of the leading causes of cancer-related death in the word. Long non-coding RNA (lncRNA) taurine-upregulated gene 1 (TUG1) plays an important role in the development and progression of numerous cancers, including BC. However, the exact role of TUG1 in modulating BC progression is still poorly known. In this study, we found that TUG1 was upregulated and microRNA-29c (miR-29c) was downregulated in BC tissues and cell lines. Overexpression of TUG1 promoted the cell proliferation of T24 and EJ cells, whereas TUG1 knockdown had the opposite effect. Upregulation of TUG1 obviously facilitated the migration and invasion of T24 and EJ cells. In contrast, TUG1 silencing repressed the migration and invasion of T24 and EJ cells. Furthermore, TUG1 knockdown markedly increased the expression of miR-29c in vitro. On the contrary, overexpression of TUG1 remarkably decreased the expression of miR-29c. Transfection with plasmids containing mutant TUG1 has no effect on the expression of miR-29c. There were direct interactions between miR-29c and the binding sites of TUG1. In addition, the inhibitory effects of small interfering RNA specific for TUG1 on BC cell proliferation, migration and invasion were reversed by downregulation of miR-29c. Collectively, our study strongly demonstrates that TUG1 promotes BC cell proliferation, migration and invasion by inhibiting miR-29c, suggesting that lncRNATUG1 may be a promising target for BC gene therapy.

The "periodic table" of the genetic code: A new way to look at the code and the decoding process.

Science.gov (United States)

Komar, Anton A

2016-01-01

Henri Grosjean and Eric Westhof recently presented an information-rich, alternative view of the genetic code, which takes into account current knowledge of the decoding process, including the complex nature of interactions between mRNA, tRNA and rRNA that take place during protein synthesis on the ribosome, and it also better reflects the evolution of the code. The new asymmetrical circular genetic code has a number of advantages over the traditional codon table and the previous circular diagrams (with a symmetrical/clockwise arrangement of the U, C, A, G bases). Most importantly, all sequence co-variances can be visualized and explained based on the internal logic of the thermodynamics of codon-anticodon interactions.

Equidistant Linear Network Codes with maximal Error-protection from Veronese Varieties

DEFF Research Database (Denmark)

Hansen, Johan P.

2012-01-01

Linear network coding transmits information in terms of a basis of a vector space and the information is received as a basis of a possible altered vectorspace. Ralf Koetter and Frank R. Kschischang in Coding for errors and erasures in random network coding (IEEE Transactions on Information Theory...... construct explicit families of vector-spaces of constant dimension where any pair of distinct vector-spaces are equidistant in the above metric. The parameters of the resulting linear network codes which have maximal error-protection are determined....

IFR code for secondary particle dynamics

International Nuclear Information System (INIS)

Teague, M.R.; Yu, S.S.

1985-01-01

A numerical simulation has been constructed to obtain a detailed, quantitative estimate of the electromagnetic fields and currents existing in the Advanced Test Accelerator under conditions of laser guiding. The code treats the secondary electrons by particle simulation and the beam dynamics by a time-dependent envelope model. The simulation gives a fully relativistic description of secondary electrons moving in self-consistent electromagnetic fields. The calculations are made using coordinates t, x, y, z for the electrons and t, ct-z, r for the axisymmetric electromagnetic fields and currents. Code results, showing in particular current enhancement effects, will be given

An intergenic non-coding rRNA correlated with expression of the rRNA and frequency of an rRNA single nucleotide polymorphism in lung cancer cells.

Directory of Open Access Journals (Sweden)

Yih-Horng Shiao

Full Text Available BACKGROUND: Ribosomal RNA (rRNA is a central regulator of cell growth and may control cancer development. A cis noncoding rRNA (nc-rRNA upstream from the 45S rRNA transcription start site has recently been implicated in control of rRNA transcription in mouse fibroblasts. We investigated whether a similar nc-rRNA might be expressed in human cancer epithelial cells, and related to any genomic characteristics. METHODOLOGY/PRINCIPAL FINDINGS: Using quantitative rRNA measurement, we demonstrated that a nc-rRNA is transcribed in human lung epithelial and lung cancer cells, starting from approximately -1000 nucleotides upstream of the rRNA transcription start site (+1 and extending at least to +203. This nc-rRNA was significantly more abundant in the majority of lung cancer cell lines, relative to a nontransformed lung epithelial cell line. Its abundance correlated negatively with total 45S rRNA in 12 of 13 cell lines (P = 0.014. During sequence analysis from -388 to +306, we observed diverse, frequent intercopy single nucleotide polymorphisms (SNPs in rRNA, with a frequency greater than predicted by chance at 12 sites. A SNP at +139 (U/C in the 5' leader sequence varied among the cell lines and correlated negatively with level of the nc-rRNA (P = 0.014. Modelling of the secondary structure of the rRNA 5'-leader sequence indicated a small increase in structural stability due to the +139 U/C SNP and a minor shift in local configuration occurrences. CONCLUSIONS/SIGNIFICANCE: The results demonstrate occurrence of a sense nc-rRNA in human lung epithelial and cancer cells, and imply a role in regulation of the rRNA gene, which may be affected by a +139 SNP in the 5' leader sequence of the primary rRNA transcript.

R7 VU Born-Assessed Demo Plan

Energy Technology Data Exchange (ETDEWEB)

Robert Nourgaliev

2010-02-01

This is an initial draft of a born-assessed VU plan for the RELAP7 (R7) code development effort. The plan will continue to evolve based on the growth of code capability. This growth will be reflected as additional testing is identified and done. Later versions of this document will reflect that growth.

The FOCON96 1.0 computer code

International Nuclear Information System (INIS)

Merle-Szeremeta, A.; Thomassin, A.

1999-01-01

The Institute of Protection and Nuclear Safety (I.P.S.N.) has developed a computer code, FOCON96 1.0 to calculate the dosimetric consequences of atmospheric radioactive releases from nuclear installations after several years of usual operation. This communication describes the principal characteristics of FOCON96 1.0 and its functionalities. The principal elements of a comparison between FOCON96 1.0 and PC-CREAM ( European computer code developed by the N.R.P.B. and answering the same criteria) are given here. (N.C.)

Changes in the Coding and Non-coding Transcriptome and DNA Methylome that Define the Schwann Cell Repair Phenotype after Nerve Injury.

Science.gov (United States)

Arthur-Farraj, Peter J; Morgan, Claire C; Adamowicz, Martyna; Gomez-Sanchez, Jose A; Fazal, Shaline V; Beucher, Anthony; Razzaghi, Bonnie; Mirsky, Rhona; Jessen, Kristjan R; Aitman, Timothy J

2017-09-12

Repair Schwann cells play a critical role in orchestrating nerve repair after injury, but the cellular and molecular processes that generate them are poorly understood. Here, we perform a combined whole-genome, coding and non-coding RNA and CpG methylation study following nerve injury. We show that genes involved in the epithelial-mesenchymal transition are enriched in repair cells, and we identify several long non-coding RNAs in Schwann cells. We demonstrate that the AP-1 transcription factor C-JUN regulates the expression of certain micro RNAs in repair Schwann cells, in particular miR-21 and miR-34. Surprisingly, unlike during development, changes in CpG methylation are limited in injury, restricted to specific locations, such as enhancer regions of Schwann cell-specific genes (e.g., Nedd4l), and close to local enrichment of AP-1 motifs. These genetic and epigenomic changes broaden our mechanistic understanding of the formation of repair Schwann cell during peripheral nervous system tissue repair. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

The miR-223 host non-coding transcript linc-223 induces IRF4 expression in acute myeloid leukemia by acting as a competing endogenous RNA

KAUST Repository

Mangiavacchi, Arianna

2016-08-10

Alterations in genetic programs required for terminal myeloid differentiation and aberrant proliferation characterize acute myeloid leukemia (AML) cells. Here, we identify the host transcript of miR-223, linc-223, as a novel functional long non-coding RNA (lncRNA) in AML. We show that from the primary nuclear transcript, the alternative production of miR-223 and linc-223 is finely regulated during monocytic differentiation. Moreover, linc-223 expression inhibits cell cycle progression and promotes monocytic differentiation of AML cells. We also demonstrate that endogenous linc-223 localizes in the cytoplasm and acts as a competing endogenous RNA for miR-125-5p, an oncogenic microRNA in leukemia. In particular, we show that linc-223 directly binds to miR-125-5p and that its knockdown increases the repressing activity of miR-125-5p resulting in the downregulation of its target interferon regulatory factor 4 (IRF4), which it was previously shown to inhibit the oncogenic activity of miR-125-5p in vivo. Furthermore, data from primary AML samples show significant downregulation of linc-223 in different AML subtypes. Therein, these findings indicate that the newly identified lncRNA linc-223 may have an important role in myeloid differentiation and leukemogenesis, at least in part, by cross-talking with IRF4 mRNA.

Comparison of beam deposition for three neutral beam injection codes

International Nuclear Information System (INIS)

Wieland, R.M.; Houlberg, W.A.; Mense, A.T.

1979-03-01

The three neutral beam injection codes BEAM (Houlberg, ORNL), HOFR (Howe, ORNL), and FREYA (Post, PPPL) are compared with respect to the calculation of the fast ion deposition profile H(r). Only plasmas of circular cross section are considered, with injection confined to the mid-plane of the torus. The approximations inherent in each code are pointed out, and a series of comparisons varying several parameters (beam energy and radius, machine size, and injection angle) shows excellent agreement among all the codes. A cost comparison (execution time and memory requirements) is made which points out the relative merits of each code within the context of incorporation into a plasma transport simulation code

Joint Machine Learning and Game Theory for Rate Control in High Efficiency Video Coding.

Science.gov (United States)

Gao, Wei; Kwong, Sam; Jia, Yuheng

2017-08-25

In this paper, a joint machine learning and game theory modeling (MLGT) framework is proposed for inter frame coding tree unit (CTU) level bit allocation and rate control (RC) optimization in High Efficiency Video Coding (HEVC). First, a support vector machine (SVM) based multi-classification scheme is proposed to improve the prediction accuracy of CTU-level Rate-Distortion (R-D) model. The legacy "chicken-and-egg" dilemma in video coding is proposed to be overcome by the learning-based R-D model. Second, a mixed R-D model based cooperative bargaining game theory is proposed for bit allocation optimization, where the convexity of the mixed R-D model based utility function is proved, and Nash bargaining solution (NBS) is achieved by the proposed iterative solution search method. The minimum utility is adjusted by the reference coding distortion and frame-level Quantization parameter (QP) change. Lastly, intra frame QP and inter frame adaptive bit ratios are adjusted to make inter frames have more bit resources to maintain smooth quality and bit consumption in the bargaining game optimization. Experimental results demonstrate that the proposed MLGT based RC method can achieve much better R-D performances, quality smoothness, bit rate accuracy, buffer control results and subjective visual quality than the other state-of-the-art one-pass RC methods, and the achieved R-D performances are very close to the performance limits from the FixedQP method.

VVER-440 loading patterns optimization using ATHENA code

International Nuclear Information System (INIS)

Katovsky, K.; Sustek, J.; Bajgl, J.; Cada, R.

2009-01-01

In this paper the Czech optimization state-of-the-art, new code system development goals and OPAL optimization system are briefly mentioned. The algorithms, maths, present status and future developments of the ATHENA code are described. A calculation exercise of the Dukovany NPP cycles, on increased power using ATHENA, starting with on-coming 24th cycle (303 FPD) continuing with 25th (322 FPD), and 26th (336 FPD); for all cycles K R ≤1.54 is presented

Representation of inhomogeneities in the flow and transport codes d{sup 3}f and r{sup 3}t

Energy Technology Data Exchange (ETDEWEB)

Schneider, Anke (ed.)

2013-09-15

The codes d{sup 3}f and r{sup 3}t are well established for modelling density-driven flow and nuclide transport in the far field of repositories for hazardous material in deep geological formations. While originally intended to be applied to the overburden of a salt dome they were adapted to alternative host media such as crystalline rock or mudstone by including fractures into an otherwise porous medium. However, only discrete fractures or fracture networks with a rather limited number of fractures could be dealt with. Networks of smaller fractures - so-called background fractures - can easily consist of hundreds and thousands of significant individual fractures in a model domain and were therefore beyond the scope of d{sup 3}f and r{sup 3}t. One way to circumvent this problem is to replace a discrete fracture network with an equivalent porous medium. While this is a task in itself the codes had also numerically adapted to be to cope with the new methods. This report describes approaches and results of this work. In groundwater flow simulation fractures are usually modelled as lower dimensional objects. But especially in the case of density driven flow situations may occur where the validity of this assumption has to be proved. Here a special approach was developed and implemented that allows an adaptive resolution of the layers. Of central relevance in this respect is the development of local refinement or coarsening criteria, an adaptive discretisation that allows an adaptive transition from low-dimensional to equidimensional modelling of the fractures, and an adaptive multigrid algorithm Furthermore, discretisation methods of higher order for the mixed parabolic-hyperbolic problems were developed. New filtering algebraic multigrid methods as efficient solvers for the large linear equation systems were implemented. The parallelisation was improved by implementation of a parallel communication layer (pcl). For the estimation of parameters for these systems by

State of art in FE-based fuel performance codes

International Nuclear Information System (INIS)

Kim, Hyo Chan; Yang, Yong Sik; Kim, Dae Ho; Bang, Je Geon; Kim, Sun Ki; Koo, Yang Hyun

2013-01-01

Finite element (FE) method that is reliable and proven solution in mechanical field has been introduced into fuel performance codes for multidimensional analysis. The present state of the art in numerical simulation of FE-based fuel performance predominantly involves 2-D axisymmetric model and 3-D volumetric model. The FRAPCON and FRAPTRAN own 1.5-D and 2-D FE model to simulate PCMI and cladding ballooning. In 2-D simulation, the FALCON code, developed by EPRI, is a 2-D (R-Z and R-θ) fully thermal-mechanically coupled steady-state and transient FE-based fuel behavior code. The French codes TOUTATIS and ALCYONE which are 3-D, and typically used to investigate localized behavior. In 2008, the Idaho National Laboratory (INL) has been developing multidimensional (2-D and 3-D) nuclear fuel performance code called BISON. In this paper, the current state of FE-based fuel performance code and their models are presented. Based on investigation into the codes, requirements and direction of development for new FE-based fuel performance code can be discussed. Based on comparison of models in FE-based fuel performance code, status of art in the codes can be discussed. A new FE-based fuel performance code should include typical pellet and cladding models which all codes own. In particular, specified pellet and cladding model such as gaseous swelling and high burnup structure (HBS) model should be developed to improve accuracy of code as well as consider AC condition. To reduce computation cost, the approximated gap and the optimized contact model should be also developed. Nuclear fuel operates in an extreme environment that induces complex multiphysics phenomena, occurring over distances ranging from inter-atomic spacing to meters, and times scales ranging from microseconds to years. This multiphysics behavior is often tightly coupled, a well known example being the thermomechanical behavior. Adding to this complexity, important aspects of fuel behavior are inherently

Theoretical atomic physics code development I: CATS: Cowan Atomic Structure Code

International Nuclear Information System (INIS)

Abdallah, J. Jr.; Clark, R.E.H.; Cowan, R.D.

1988-12-01

An adaptation of R.D. Cowan's Atomic Structure program, CATS, has been developed as part of the Theoretical Atomic Physics (TAPS) code development effort at Los Alamos. CATS has been designed to be easy to run and to produce data files that can interface with other programs easily. The CATS produced data files currently include wave functions, energy levels, oscillator strengths, plane-wave-Born electron-ion collision strengths, photoionization cross sections, and a variety of other quantities. This paper describes the use of CATS. 10 refs

Calculation of the RSG-GAS core using computer code citation-3D

International Nuclear Information System (INIS)

Taryo, T.; Rokhmadi

1998-01-01

Since core reactivity is one of the reactor safety parameters, this R and D has been carried out. To carry out the R and D, the code called WIMSD4 was used respectively for generating cross section and diffusion parameters. The code CITATION was then applied to estimate core reactivity in the RSG-GAS core. To verify the result of the calculation, data and information of the RSG-GAS Typical Working Core Were used. To Prove the codes reliably used, the case of all control elements down in the reactor core and that of all control rods up in the core were applied. The result taking into account those cases showed respectively that K eff are less and greater than unity (K eff eff >1)

microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus

DEFF Research Database (Denmark)

Leucci, Eleonora; Patella, Francesca; Waage, Johannes

2013-01-01

-coding RNAs. Here we report that microRNA-9 (miR-9) regulates the expression of the Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT-1), one of the most abundant and conserved long non-coding RNAs. Intriguingly, we find that miR-9 targets AGO2-mediated regulation of MALAT1 in the nucleus. Our...

Enrichment of Circular Code Motifs in the Genes of the Yeast Saccharomyces cerevisiae

Directory of Open Access Journals (Sweden)

Christian J. Michel

2017-12-01

Full Text Available A set X of 20 trinucleotides has been found to have the highest average occurrence in the reading frame, compared to the two shifted frames, of genes of bacteria, archaea, eukaryotes, plasmids and viruses. This set X has an interesting mathematical property, since X is a maximal C 3 self-complementary trinucleotide circular code. Furthermore, any motif obtained from this circular code X has the capacity to retrieve, maintain and synchronize the original (reading frame. Since 1996, the theory of circular codes in genes has mainly been developed by analysing the properties of the 20 trinucleotides of X , using combinatorics and statistical approaches. For the first time, we test this theory by analysing the X motifs, i.e., motifs from the circular code X , in the complete genome of the yeast Saccharomyces cerevisiae. Several properties of X motifs are identified by basic statistics (at the frequency level, and evaluated by comparison to R motifs, i.e., random motifs generated from 30 different random codes R . We first show that the frequency of X motifs is significantly greater than that of R motifs in the genome of S. cerevisiae. We then verify that no significant difference is observed between the frequencies of X and R motifs in the non-coding regions of S. cerevisiae, but that the occurrence number of X motifs is significantly higher than R motifs in the genes (protein-coding regions. This property is true for all cardinalities of X motifs (from 4 to 20 and for all 16 chromosomes. We further investigate the distribution of X motifs in the three frames of S. cerevisiae genes and show that they occur more frequently in the reading frame, regardless of their cardinality or their length. Finally, the ratio of X genes, i.e., genes with at least one X motif, to non- X genes, in the set of verified genes is significantly different to that observed in the set of putative or dubious genes with no experimental evidence. These results, taken together

Enrichment of Circular Code Motifs in the Genes of the Yeast Saccharomyces cerevisiae.

Science.gov (United States)

Michel, Christian J; Ngoune, Viviane Nguefack; Poch, Olivier; Ripp, Raymond; Thompson, Julie D

2017-12-03

A set X of 20 trinucleotides has been found to have the highest average occurrence in the reading frame, compared to the two shifted frames, of genes of bacteria, archaea, eukaryotes, plasmids and viruses. This set X has an interesting mathematical property, since X is a maximal C3 self-complementary trinucleotide circular code. Furthermore, any motif obtained from this circular code X has the capacity to retrieve, maintain and synchronize the original (reading) frame. Since 1996, the theory of circular codes in genes has mainly been developed by analysing the properties of the 20 trinucleotides of X, using combinatorics and statistical approaches. For the first time, we test this theory by analysing the X motifs, i.e., motifs from the circular code X, in the complete genome of the yeast Saccharomyces cerevisiae . Several properties of X motifs are identified by basic statistics (at the frequency level), and evaluated by comparison to R motifs, i.e., random motifs generated from 30 different random codes R. We first show that the frequency of X motifs is significantly greater than that of R motifs in the genome of S. cerevisiae . We then verify that no significant difference is observed between the frequencies of X and R motifs in the non-coding regions of S. cerevisiae , but that the occurrence number of X motifs is significantly higher than R motifs in the genes (protein-coding regions). This property is true for all cardinalities of X motifs (from 4 to 20) and for all 16 chromosomes. We further investigate the distribution of X motifs in the three frames of S. cerevisiae genes and show that they occur more frequently in the reading frame, regardless of their cardinality or their length. Finally, the ratio of X genes, i.e., genes with at least one X motif, to non-X genes, in the set of verified genes is significantly different to that observed in the set of putative or dubious genes with no experimental evidence. These results, taken together, represent the first

ORMEC: a three-dimensional MHD spectral inverse equilibrium code

International Nuclear Information System (INIS)

Hirshman, S.P.; Hogan, J.T.

1986-02-01

The Oak Ridge Moments Equilibrium Code (ORMEC) is an efficient computer code that has been developed to calculate three-dimensional MHD equilibria using the inverse spectral method. The fixed boundary formulation, which is based on a variational principle for the spectral coefficients (moments) of the cylindrical coordinates R and Z, is described and compared with the finite difference code BETA developed by Bauer, Betancourt, and Garabedian. Calculations for the Heliotron, Wendelstein VIIA, and Advanced Toroidal Facility (ATF) configurations are performed to establish the accuracy and mesh convergence properties for the spectral method. 16 refs., 13 figs

TURTLE 24.0 diffusion depletion code

International Nuclear Information System (INIS)

Altomare, S.; Barry, R.F.

1971-09-01

TURTLE is a two-group, two-dimensional (x-y, x-z, r-z) neutron diffusion code featuring a direct treatment of the nonlinear effects of xenon, enthalpy, and Doppler. Fuel depletion is allowed. TURTLE was written for the study of azimuthal xenon oscillations, but the code is useful for general analysis. The input is simple, fuel management is handled directly, and a boron criticality search is allowed. Ten thousand space points are allowed (over 20,000 with diagonal symmetry). TURTLE is written in FORTRAN IV and is tailored for the present CDC-6600. The program is core-contained. Provision is made to save data on tape for future reference. (auth)

Convex Optimization in R

Directory of Open Access Journals (Sweden)

Roger Koenker

2014-09-01

Full Text Available Convex optimization now plays an essential role in many facets of statistics. We briefly survey some recent developments and describe some implementations of these methods in R . Applications of linear and quadratic programming are introduced including quantile regression, the Huber M-estimator and various penalized regression methods. Applications to additively separable convex problems subject to linear equality and inequality constraints such as nonparametric density estimation and maximum likelihood estimation of general nonparametric mixture models are described, as are several cone programming problems. We focus throughout primarily on implementations in the R environment that rely on solution methods linked to R, like MOSEK by the package Rmosek. Code is provided in R to illustrate several of these problems. Other applications are available in the R package REBayes, dealing with empirical Bayes estimation of nonparametric mixture models.

The Long Non-Coding RNA XIST Interacted with MiR-124 to Modulate Bladder Cancer Growth, Invasion and Migration by Targeting Androgen Receptor (AR).

Science.gov (United States)

Xiong, Yaoyao; Wang, Long; Li, Yuan; Chen, Minfeng; He, Wei; Qi, Lin

2017-01-01

Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is involved in the progression of several tumors. The interaction between lncRNA and miRNA or miRNA's target genes is reported to play crucial roles in malignancy. In addition, Androgen receptor (AR) is considered to be involved in bladder cancer progression. In this study, we investigated the role of XIST in human bladder cancer and its interaction with miR-124 and AR. XIST and AR expression was detected in bladder tumor samples and cell lines. Effects of XIST and AR on bladder cancer cells growth, invasion and migration were analyzed. Bioinformatic analysis and luciferase assays were used to identify the interaction among XIST, AR and miR-124. The correlations of miR-124 with XIST and AR in bladder cancer samples were statistically analyzed. XIST and AR were upregulated in bladder cancer tissues and positively correlated. Higher XIST and AR expression were related to poorer TNM stage of bladder cancer. XIST knockdown reduced bladder cancer cells' proliferation, invasion and migration. While this inhibitory effect could be partially restored by AR overexpression. XIST inhibited miR-124 expression by directly targeting. Moreover, miR-124 could bind to the 3'UTR of AR to regulate its expression. MiR-124 inhibition partially restored the XIST knockdown-induced reduction of AR, c-myc, p27, MMP13 and MMP9 expression. In bladder cancer tissues, miR-124 level was inversely correlated with the expression of XIST and AR, respectively. These findings indicated that XIST might be an oncogenic lncRNA that promoted the bladder cancer growth, invasion and migration via miR-124 dependent AR regulation. © 2017 The Author(s). Published by S. Karger AG, Basel.

The Long Non-Coding RNA XIST Interacted with MiR-124 to Modulate Bladder Cancer Growth, Invasion and Migration by Targeting Androgen Receptor (AR

Directory of Open Access Journals (Sweden)

Yaoyao Xiong

2017-08-01

Full Text Available Backgrounds/Aims: Long non-coding RNA (lncRNA X-inactive specific transcript (XIST is involved in the progression of several tumors. The interaction between lncRNA and miRNA or miRNA’s target genes is reported to play crucial roles in malignancy. In addition, Androgen receptor (AR is considered to be involved in bladder cancer progression. In this study, we investigated the role of XIST in human bladder cancer and its interaction with miR-124 and AR. Methods: XIST and AR expression was detected in bladder tumor samples and cell lines. Effects of XIST and AR on bladder cancer cells growth, invasion and migration were analyzed. Bioinformatic analysis and luciferase assays were used to identify the interaction among XIST, AR and miR-124. The correlations of miR-124 with XIST and AR in bladder cancer samples were statistically analyzed. Results: XIST and AR were upregulated in bladder cancer tissues and positively correlated. Higher XIST and AR expression were related to poorer TNM stage of bladder cancer. XIST knockdown reduced bladder cancer cells’ proliferation, invasion and migration. While this inhibitory effect could be partially restored by AR overexpression. XIST inhibited miR-124 expression by directly targeting. Moreover, miR-124 could bind to the 3’UTR of AR to regulate its expression. MiR-124 inhibition partially restored the XIST knockdown-induced reduction of AR, c-myc, p27, MMP13 and MMP9 expression. In bladder cancer tissues, miR-124 level was inversely correlated with the expression of XIST and AR, respectively. Conclusion: These findings indicated that XIST might be an oncogenic lncRNA that promoted the bladder cancer growth, invasion and migration via miR-124 dependent AR regulation.

New extremal binary self-dual codes of lengths 64 and 66 from bicubic planar graphs

OpenAIRE

Kaya, Abidin

2016-01-01

In this work, connected cubic planar bipartite graphs and related binary self-dual codes are studied. Binary self-dual codes of length 16 are obtained by face-vertex incidence matrices of these graphs. By considering their lifts to the ring R_2 new extremal binary self-dual codes of lengths 64 are constructed as Gray images. More precisely, we construct 15 new codes of length 64. Moreover, 10 new codes of length 66 were obtained by applying a building-up construction to the binary codes. Code...

TRIPOLI-4R Version 8 User Guide

International Nuclear Information System (INIS)

Brun, Emeric; Damian, Frederic; Dumonteil, Eric; Hugot, Francois-Xavier; Lee, Yi-Kang; Malvagi, Fausto; Mazzolo, Alain; Petit, Odile; Trama, Jean-Christophe; Visonneau, Thierry; Zoia, Andrea

2013-02-01

TRIPOLI-4 R solves the linear Boltzmann equation for neutrons, photons, electrons and positrons, with the Monte Carlo method, in any 3D geometry. The code uses ENDF format continuous energy cross-sections, from various international evaluations including JEFF-3.1.1, ENDF/B-VII.0, JENDL4 and FENDL2.1. Its official nuclear data library for applications, named CEAV5.1.1, is mainly based on the European evaluation JEFF-3.1.1. TRIPOLI-4 R solves fixed source as well as eigenvalue problems. It has advanced variance reduction methods to address deep penetration issues. Thanks to its robust and efficient parallelism capability, calculations are easily performed on multi-core single units, heterogeneous networks of workstations and massively parallel machines. Additional productivity tools, graphical as well as algorithmic, allow the user to efficiently set its input decks. With its large V and V data base, TRIPOLI-4 R is used as a reference code for industrial purposes, as well as a R and D and teaching tool, for radiation protection and shielding, core physics, nuclear criticality-safety and nuclear instrumentation. TRIPOLI-4 R is a registered trademark of CEA. (authors)

Hybrid coded aperture and Compton imaging using an active mask

International Nuclear Information System (INIS)

Schultz, L.J.; Wallace, M.S.; Galassi, M.C.; Hoover, A.S.; Mocko, M.; Palmer, D.M.; Tornga, S.R.; Kippen, R.M.; Hynes, M.V.; Toolin, M.J.; Harris, B.; McElroy, J.E.; Wakeford, D.; Lanza, R.C.; Horn, B.K.P.; Wehe, D.K.

2009-01-01

The trimodal imager (TMI) images gamma-ray sources from a mobile platform using both coded aperture (CA) and Compton imaging (CI) modalities. In this paper we will discuss development and performance of image reconstruction algorithms for the TMI. In order to develop algorithms in parallel with detector hardware we are using a GEANT4 [J. Allison, K. Amako, J. Apostolakis, H. Araujo, P.A. Dubois, M. Asai, G. Barrand, R. Capra, S. Chauvie, R. Chytracek, G. Cirrone, G. Cooperman, G. Cosmo, G. Cuttone, G. Daquino, et al., IEEE Trans. Nucl. Sci. NS-53 (1) (2006) 270] based simulation package to produce realistic data sets for code development. The simulation code incorporates detailed detector modeling, contributions from natural background radiation, and validation of simulation results against measured data. Maximum likelihood algorithms for both imaging methods are discussed, as well as a hybrid imaging algorithm wherein CA and CI information is fused to generate a higher fidelity reconstruction.

FINELM: a multigroup finite element diffusion code. Part I

International Nuclear Information System (INIS)

Davierwalla, D.M.

1980-12-01

The author presents a two dimensional code for multigroup diffusion using the finite element method. It was realized that the extensive connectivity which contributes significantly to the accuracy, results in a matrix which, although symmetric and positive definite, is wide band and possesses an irregular profile. Hence, it was decided to introduce sparsity techniques into the code. The introduction of the R-Z geometry lead to a great deal of changes in the code since the rotational invariance of the removal matrices in X-Y geometry did not carry over in R-Z geometry. Rectangular elements were introduced to remedy the inability of the triangles to model essentially one dimensional problems such as slab geometry. The matter is discussed briefly in the text in the section on benchmark problems. This report is restricted to the general theory of the triangular elements and to the sparsity techniques viz. incomplete disections. The latter makes the size of the problem that can be handled independent of core memory and dependent only on disc storage capacity which is virtually unlimited. (Auth.)

Applicability of coupled code RELAP5/GOTHIC to NPP Krsko MSLB calculation

International Nuclear Information System (INIS)

Keco, M.; Debrecin, N.; Grgic, D.

2005-01-01

Usual way to analyze Main Steam Line Break (MSLB) accident in PWR plants is to calculate core and containment responses in two separate calculations. In first calculation system code is used to address behaviour of nuclear steam supply system and containment is modelled mainly as a boundary condition. In second calculation mass and energy release data are used to perform containment analysis. Coupled code R5G realized by direct explicit coupling of system code RELAP5/MOD3.3 and containment code GOTHIC is able to perform both calculations simultaneously. In this paper R5G is applied to calculation of MSLB accident in large dry containment of NPP Krsko. Standard separate calculation is performed first and then both core and containment responses are compared against corresponding coupled code results. Two versions of GOTHIC code are used, one old ver 3.4e and the last one ver 7.2. As expected, differences between standard procedure and coupled calculations are small. The performed analyses showed that classical uncoupled approach is applicable in case of large dry containment calculation, but that new approach can bring some additional insight in understanding of the transient and that can be used as simple and reliable procedure in performing MSLB calculation without any significant calculation overhead. (author)

TractoR: Magnetic Resonance Imaging and Tractography with R

Directory of Open Access Journals (Sweden)

Chris A. Clark

2011-10-01

Full Text Available Statistical techniques play a major role in contemporary methods for analyzing magnetic resonance imaging (MRI data. In addition to the central role that classical statistical methods play in research using MRI, statistical modeling and machine learning techniques are key to many modern data analysis pipelines. Applications for these techniques cover a broad spectrum of research, including many preclinical and clinical studies, and in some cases these methods are working their way into widespread routine use. In this manuscript we describe a software tool called TractoR (for “Tractography with R”, a collection of packages for the R language and environment, along with additional infrastructure for straightforwardly performing common image processing tasks. TractoR provides general purpose functions for reading, writing and manipulating MR images, as well as more specific code for fitting signal models to diffusion MRI data and performing tractography, a technique for visualizing neural connectivity.

The computer code EURDYN-1M (release 2). User's manual

International Nuclear Information System (INIS)

1982-01-01

EURDYN-1M is a finite element computer code developed at J.R.C. Ispra to compute the response of two-dimensional coupled fluid-structure configurations to transient dynamic loading for reactor safety studies. This report gives instructions for preparing input data to EURDYN-1M, release 2, and describes a test problem in order to illustrate both the input and the output of the code

From concatenated codes to graph codes

DEFF Research Database (Denmark)

Justesen, Jørn; Høholdt, Tom

2004-01-01

We consider codes based on simple bipartite expander graphs. These codes may be seen as the first step leading from product type concatenated codes to more complex graph codes. We emphasize constructions of specific codes of realistic lengths, and study the details of decoding by message passing...

Development of a computer code for Dalat research reactor transient analysis

International Nuclear Information System (INIS)

Le Vinh Vinh; Nguyen Thai Sinh; Huynh Ton Nghiem; Luong Ba Vien; Pham Van Lam; Nguyen Kien Cuong

2003-01-01

DRSIM (Dalat Reactor SIMulation) computer code has been developed for Dalat reactor transient analysis. It is basically a coupled neutronics-hydrodynamics-heat transfer code employing point kinetics, one dimensional hydrodynamics and one dimensional heat transfer. The work was financed by VAEC and DNRI in the framework of institutional R and D programme. Some transient problems related to reactivity and loss of coolant flow was carried out by DRSIM using temperature and void coefficients calculated by WIMS and HEXNOD2D codes. (author)

Improvement on reaction model for sodium-water reaction jet code and application analysis

International Nuclear Information System (INIS)

Itooka, Satoshi; Saito, Yoshinori; Okabe, Ayao; Fujimata, Kazuhiro; Murata, Shuuichi

2000-03-01

In selecting the reasonable DBL on steam generator (SG), it is necessary to improve analytical method for estimating the sodium temperature on failure propagation due to overheating. Improvement on sodium-water reaction (SWR) jet code (LEAP-JET ver.1.30) and application analysis to the water injection tests for confirmation of code propriety were performed. On the improvement of the code, a gas-liquid interface area density model was introduced to develop a chemical reaction model with a little dependence on calculation mesh size. The test calculation using the improved code (LEAP-JET ver.1.40) were carried out with conditions of the SWAT-3·Run-19 test and an actual scale SG. It is confirmed that the SWR jet behavior on the results and the influence to analysis result of a model are reasonable. For the application analysis to the water injection tests, water injection behavior and SWR jet behavior analyses on the new SWAT-1 (SWAT-1R) and SWAT-3 (SWAT-3R) tests were performed using the LEAP-BLOW code and the LEAP-JET code. In the application analysis of the LEAP-BLOW code, parameter survey study was performed. As the results, the condition of the injection nozzle diameter needed to simulate the water leak rate was confirmed. In the application analysis of the LEAP-JET code, temperature behavior of the SWR jet was investigated. (author)

Rosen's (M,R) system in Unified Modelling Language.

Science.gov (United States)

Zhang, Ling; Williams, Richard A; Gatherer, Derek

2016-01-01

Robert Rosen's (M,R) system is an abstract biological network architecture that is allegedly non-computable on a Turing machine. If (M,R) is truly non-computable, there are serious implications for the modelling of large biological networks in computer software. A body of work has now accumulated addressing Rosen's claim concerning (M,R) by attempting to instantiate it in various software systems. However, a conclusive refutation has remained elusive, principally since none of the attempts to date have unambiguously avoided the critique that they have altered the properties of (M,R) in the coding process, producing merely approximate simulations of (M,R) rather than true computational models. In this paper, we use the Unified Modelling Language (UML), a diagrammatic notation standard, to express (M,R) as a system of objects having attributes, functions and relations. We believe that this instantiates (M,R) in such a way than none of the original properties of the system are corrupted in the process. Crucially, we demonstrate that (M,R) as classically represented in the relational biology literature is implicitly a UML communication diagram. Furthermore, since UML is formally compatible with object-oriented computing languages, instantiation of (M,R) in UML strongly implies its computability in object-oriented coding languages. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

A Bioinformatics Analysis Reveals a Group of MocR Bacterial Transcriptional Regulators Linked to a Family of Genes Coding for Membrane Proteins

Directory of Open Access Journals (Sweden)

Teresa Milano

2016-01-01

Full Text Available The MocR bacterial transcriptional regulators are characterized by an N-terminal domain, 60 residues long on average, possessing the winged-helix-turn-helix (wHTH architecture responsible for DNA recognition and binding, linked to a large C-terminal domain (350 residues on average that is homologous to fold type-I pyridoxal 5′-phosphate (PLP dependent enzymes like aspartate aminotransferase (AAT. These regulators are involved in the expression of genes taking part in several metabolic pathways directly or indirectly connected to PLP chemistry, many of which are still uncharacterized. A bioinformatics analysis is here reported that studied the features of a distinct group of MocR regulators predicted to be functionally linked to a family of homologous genes coding for integral membrane proteins of unknown function. This group occurs mainly in the Actinobacteria and Gammaproteobacteria phyla. An analysis of the multiple sequence alignments of their wHTH and AAT domains suggested the presence of specificity-determining positions (SDPs. Mapping of SDPs onto a homology model of the AAT domain hinted at possible structural/functional roles in effector recognition. Likewise, SDPs in wHTH domain suggested the basis of specificity of Transcription Factor Binding Site recognition. The results reported represent a framework for rational design of experiments and for bioinformatics analysis of other MocR subgroups.

Knockdown of long non-coding RNA HOTAIR increases miR-454-3p by targeting Stat3 and Atg12 to inhibit chondrosarcoma growth.

Science.gov (United States)

Bao, Xing; Ren, Tingting; Huang, Yi; Sun, Kunkun; Wang, Shidong; Liu, Kuisheng; Zheng, Bingxin; Guo, Wei

2017-02-09

Current practices for the therapy of chondrosarcoma, including wide-margin surgical resection and chemotherapy, are less than satisfactory. Recently, emerging evidence has demonstrated that long non-coding RNAs (lncRNAs) have an essential role in the initiation and progression of tumors. As a typical lncRNA, HOTAIR is significantly overexpressed in various tumors. However, the function and potential biological mechanisms of HOTAIR in human chondrosarcoma remain unknown. Quantitative RT-PCR demonstrated that HOTAIR expression was upregulated in chondrosarcoma tissues and cell lines. High HOTAIR expression is correlated with tumor stage and poor prognosis. Functional experiments reveal that HOTAIR knockdown leads to growth inhibition of human chondrosarcoma cells in vitro and in vivo. In addition to cycle arrest and apoptosis, knockdown of HOTAIR inhibits autophagy, which favors cell death. Mechanistically, we demonstrated that HOTAIR induced DNA methylation of miR-454-3p by recruiting EZH2 and DNMT1 to the miR-454-3p promoter regions, which markedly silences miR-454-3p expression. Further analysis revealed that STAT3 and ATG12 are targets of miR-454-3p, initiate HOTAIR deficiency-induced apoptosis and reduce autophagy. Collectively, our data reveal the roles and functional mechanisms of HOTAIR in human chondrosarcoma and suggest that HOTAIR may act as a prognostic biomarker and potential therapeutic target for chondrosarcoma.

Nonfunctionality of Aspergillus sojae aflR in a strain of Aspergillus parasiticus with a disrupted aflR gene.

Science.gov (United States)

Takahashi, Tadashi; Chang, Perng-Kuang; Matsushima, Kenichiro; Yu, Jiujiang; Abe, Keietsu; Bhatnagar, Deepak; Cleveland, Thomas E; Koyama, Yasuji

2002-08-01

Aspergillus sojae belongs to the Aspergillus section Flavi but does not produce aflatoxins. The functionality of the A. sojae aflR gene (aflRs) was examined by transforming it into an DeltaaflR strain of A. parasiticus, derived from a nitrate-nonutilizing, versicolorin A (VERA)-accumulating strain. The A. parasiticus aflR gene (aflRp) transformants produced VERA, but the aflRs transformants did not. Even when aflRs was placed under the control of the amylase gene (amyB) promoter of Aspergillus oryzae, the amy(p)::aflRs transformants did not produce VERA. A chimeric construct containing the aflRs promoter plus the aflRs N- and aflRp C-terminal coding regions could restore VERA production, but a construct containing the aflRp promoter plus the aflRp N- and aflRs C-terminal coding regions could not. These results show that the A. sojae aflR promoter is functional in A. parasiticus and that the HAHA motif does not affect the function of the resulting hybrid AflR. We conclude that the lack of aflatoxin production by A. sojae can be attributed, at least partially, to the premature termination defect in aflRs, which deletes the C-terminal transcription activation domain that is critical for the expression of aflatoxin biosynthetic genes.

The development of depletion program coupled with Monte Carlo computer code

International Nuclear Information System (INIS)

Nguyen Kien Cuong; Huynh Ton Nghiem; Vuong Huu Tan

2015-01-01

The paper presents the development of depletion code for light water reactor coupled with MCNP5 code called the MCDL code (Monte Carlo Depletion for Light Water Reactor). The first order differential depletion system equations of 21 actinide isotopes and 50 fission product isotopes are solved by the Radau IIA Implicit Runge Kutta (IRK) method after receiving neutron flux, reaction rates in one group energy and multiplication factors for fuel pin, fuel assembly or whole reactor core from the calculation results of the MCNP5 code. The calculation for beryllium poisoning and cooling time is also integrated in the code. To verify and validate the MCDL code, high enriched uranium (HEU) and low enriched uranium (LEU) fuel assemblies VVR-M2 types and 89 fresh HEU fuel assemblies, 92 LEU fresh fuel assemblies cores of the Dalat Nuclear Research Reactor (DNRR) have been investigated and compared with the results calculated by the SRAC code and the MCNP R EBUS linkage system code. The results show good agreement between calculated data of the MCDL code and reference codes. (author)

Impact testing and analysis for structural code benchmarking

International Nuclear Information System (INIS)

Glass, R.E.

1989-01-01

Sandia National Laboratories, in cooperation with industry and other national laboratories, has been benchmarking computer codes used to predict the structural, thermal, criticality, and shielding behavior of radioactive materials packages. The first step in the benchmarking of the codes was to develop standard problem sets and to compare the results from several codes and users. This step for structural analysis codes has been completed as described in Structural Code Benchmarking for the Analysis of Impact Response of Nuclear Material Shipping Casks, R.E. Glass, Sandia National Laboratories, 1985. The problem set is shown in Fig. 1. This problem set exercised the ability of the codes to predict the response to end (axisymmetric) and side (plane strain) impacts with both elastic and elastic/plastic materials. The results from these problems showed that there is good agreement in predicting elastic response. Significant differences occurred in predicting strains for the elastic/plastic models. An example of the variation in predicting plastic behavior is given, which shows the hoop strain as a function of time at the impacting end of Model B. These differences in predicting plastic strains demonstrated a need for benchmark data for a cask-like problem

Advanced Object-Oriented Programming in R

DEFF Research Database (Denmark)

Mailund, Thomas

2017-01-01

Learn how to write object-oriented programs in R and how to construct classes and class hierarchies in the three object-oriented systems available in R. This book gives an introduction to object-oriented programming in the R programming language and shows you how to use and apply R in an object......-oriented manner. You will then be able to use this powerful programming style in your own statistical programming projects to write flexible and extendable software. After reading Advanced Object-Oriented Programming in R, you'll come away with a practical project that you can reuse in your own analytics coding...... of data being manipulated. You will: Define and use classes and generic functions using R Work with the R class hierarchies Benefit from implementation reuse Handle operator overloading Apply the S4 and R6 classes...

Advanced Object-Oriented Programming in R

DEFF Research Database (Denmark)

Mailund, Thomas

Learn how to write object-oriented programs in R and how to construct classes and class hierarchies in the three object-oriented systems available in R. This book gives an introduction to object-oriented programming in the R programming language and shows you how to use and apply R in an object......-oriented manner. You will then be able to use this powerful programming style in your own statistical programming projects to write flexible and extendable software. After reading Advanced Object-Oriented Programming in R, you'll come away with a practical project that you can reuse in your own analytics coding...... of data being manipulated. You will: Define and use classes and generic functions using R Work with the R class hierarchies Benefit from implementation reuse Handle operator overloading Apply the S4 and R6 classes...

Automatic coding method of the ACR Code

International Nuclear Information System (INIS)

Park, Kwi Ae; Ihm, Jong Sool; Ahn, Woo Hyun; Baik, Seung Kook; Choi, Han Yong; Kim, Bong Gi

1993-01-01

The authors developed a computer program for automatic coding of ACR(American College of Radiology) code. The automatic coding of the ACR code is essential for computerization of the data in the department of radiology. This program was written in foxbase language and has been used for automatic coding of diagnosis in the Department of Radiology, Wallace Memorial Baptist since May 1992. The ACR dictionary files consisted of 11 files, one for the organ code and the others for the pathology code. The organ code was obtained by typing organ name or code number itself among the upper and lower level codes of the selected one that were simultaneous displayed on the screen. According to the first number of the selected organ code, the corresponding pathology code file was chosen automatically. By the similar fashion of organ code selection, the proper pathologic dode was obtained. An example of obtained ACR code is '131.3661'. This procedure was reproducible regardless of the number of fields of data. Because this program was written in 'User's Defined Function' from, decoding of the stored ACR code was achieved by this same program and incorporation of this program into program in to another data processing was possible. This program had merits of simple operation, accurate and detail coding, and easy adjustment for another program. Therefore, this program can be used for automation of routine work in the department of radiology

Form Quality in Rorschach Comprehensive System and R-PAS: Sample of Psychiatric Cases

Directory of Open Access Journals (Sweden)

Latife Yazigi

2016-04-01

Full Text Available Abstract The creation of the Rorschach Performance Assessment System (R-PAS requires research that allows its use in the Brazilian population. The Formal Quality (FQ category is essential both for clinic and research. The aim of this study was to compare form quality variables in Rorschach protocols from psychiatric patients and ratings coded in the Comprehensive System (CS and R-PAS. The sample comprised 206 Rorschach protocols from adult patients in psychiatric treatment, who were also assessed by SCID-I and SCID-II. Most protocols were administered in the CS and recoded according to the R-PAS. The kappa coefficient was calculated, and we compared the means of these variables in both systems. The kappa results varied from almost perfect to substantial consistency for all variables, however, the descriptive statistics confirmed that the R-PAS elicits more FQ Ordinary coding while the CS elicits more FQ minus coding.

Containment Code Validation Matrix

International Nuclear Information System (INIS)

Chin, Yu-Shan; Mathew, P.M.; Glowa, Glenn; Dickson, Ray; Liang, Zhe; Leitch, Brian; Barber, Duncan; Vasic, Aleks; Bentaib, Ahmed; Journeau, Christophe; Malet, Jeanne; Studer, Etienne; Meynet, Nicolas; Piluso, Pascal; Gelain, Thomas; Michielsen, Nathalie; Peillon, Samuel; Porcheron, Emmanuel; Albiol, Thierry; Clement, Bernard; Sonnenkalb, Martin; Klein-Hessling, Walter; Arndt, Siegfried; Weber, Gunter; Yanez, Jorge; Kotchourko, Alexei; Kuznetsov, Mike; Sangiorgi, Marco; Fontanet, Joan; Herranz, Luis; Garcia De La Rua, Carmen; Santiago, Aleza Enciso; Andreani, Michele; Paladino, Domenico; Dreier, Joerg; Lee, Richard; Amri, Abdallah

2014-01-01

The Committee on the Safety of Nuclear Installations (CSNI) formed the CCVM (Containment Code Validation Matrix) task group in 2002. The objective of this group was to define a basic set of available experiments for code validation, covering the range of containment (ex-vessel) phenomena expected in the course of light and heavy water reactor design basis accidents and beyond design basis accidents/severe accidents. It was to consider phenomena relevant to pressurised heavy water reactor (PHWR), pressurised water reactor (PWR) and boiling water reactor (BWR) designs of Western origin as well as of Eastern European VVER types. This work would complement the two existing CSNI validation matrices for thermal hydraulic code validation (NEA/CSNI/R(1993)14) and In-vessel core degradation (NEA/CSNI/R(2001)21). The report initially provides a brief overview of the main features of a PWR, BWR, CANDU and VVER reactors. It also provides an overview of the ex-vessel corium retention (core catcher). It then provides a general overview of the accident progression for light water and heavy water reactors. The main focus is to capture most of the phenomena and safety systems employed in these reactor types and to highlight the differences. This CCVM contains a description of 127 phenomena, broken down into 6 categories: - Containment Thermal-hydraulics Phenomena; - Hydrogen Behaviour (Combustion, Mitigation and Generation) Phenomena; - Aerosol and Fission Product Behaviour Phenomena; - Iodine Chemistry Phenomena; - Core Melt Distribution and Behaviour in Containment Phenomena; - Systems Phenomena. A synopsis is provided for each phenomenon, including a description, references for further information, significance for DBA and SA/BDBA and a list of experiments that may be used for code validation. The report identified 213 experiments, broken down into the same six categories (as done for the phenomena). An experiment synopsis is provided for each test. Along with a test description

Influence of reactor vessel nodalization in the coupled code analysis of Asymmetric Main Feedwater Isolation

International Nuclear Information System (INIS)

Bencik, V.; Feretic, D.; Grgic, D.

2001-01-01

Asymmetric Main Feedwater Isolation (AMFWI) transient in one Steam Generator (SG) for NPP Krsko using RELAP5 standalone code and coupled code RELAP5- QUABOX/CUBBOX (R5QC) was analyzed. In the RELAP5 standalone calculation, a point kinetics model was used, while in the coupled code a three-dimensional (3D) neutronics model of QUABOX with different RELAP5 nodalization schemes of reactor vessel was used. Both code versions use best-estimate thermal-hydraulic system code for all components in the plant and include realistic description of plant protection and control systems. Two different types of calculations were performed: with and without automatic control rod system available. The AMFWI transient causes the great asymmetry of the transferred heat in the SGs and subsequently the asymmetry of the power produced across the core due to different reactivity feedback resulting from the thermal-hydraulic channels assigned to different loops. The work presented in the paper is a part of validation of the 3D coupled code R5QC in the analysis of asymmetric transients.(author)

Web- and system-code based, interactive, nuclear power plant simulators

International Nuclear Information System (INIS)

Kim, K. D.; Jain, P.; Rizwan, U.

2006-01-01

Using two different approaches, on-line, web- and system-code based graphical user interfaces have been developed for reactor system analysis. Both are LabVIEW (graphical programming language developed by National Instruments) based systems that allow local users as well as those at remote sites to run, interact and view the results of the system code in a web browser. In the first approach, only the data written by the system code in a tab separated ASCII output file is accessed and displayed graphically. In the second approach, LabVIEW virtual instruments are coupled with the system code as dynamic link libraries (DLL). RELAP5 is used as the system code to demonstrate the capabilities of these approaches. From collaborative projects between teams in geographically remote locations to providing system code experience to distance education students, these tools can be very beneficial in many areas of teaching and R and D. (authors)

A study on the radionuclide migration by means of the code LISA

International Nuclear Information System (INIS)

Frenquellucci, F.; Deserti, M.

1989-01-01

LISA code (Long Term Isolation Safety Assessment) has been developed by J.R.C. EUROATOM Ispra (Radiochemistry Division) and it's utilized in order to study migration of radionuclides through porous media. Aim of the present work is to analyze LISA's input and output files. A brief description of the code is also performed. As LISA is a research and in development code, its structure is rather complex and an exhaustive description of input/output files is helpful for the user. Version 3 of LISA code, loaded on ENEA's IBM 3090, is avaylable by ENEA-VEL Bologna

Coding in pigeons: Multiple-coding versus single-code/default strategies.

Science.gov (United States)

Pinto, Carlos; Machado, Armando

2015-05-01

To investigate the coding strategies that pigeons may use in a temporal discrimination tasks, pigeons were trained on a matching-to-sample procedure with three sample durations (2s, 6s and 18s) and two comparisons (red and green hues). One comparison was correct following 2-s samples and the other was correct following both 6-s and 18-s samples. Tests were then run to contrast the predictions of two hypotheses concerning the pigeons' coding strategies, the multiple-coding and the single-code/default. According to the multiple-coding hypothesis, three response rules are acquired, one for each sample. According to the single-code/default hypothesis, only two response rules are acquired, one for the 2-s sample and a "default" rule for any other duration. In retention interval tests, pigeons preferred the "default" key, a result predicted by the single-code/default hypothesis. In no-sample tests, pigeons preferred the key associated with the 2-s sample, a result predicted by multiple-coding. Finally, in generalization tests, when the sample duration equaled 3.5s, the geometric mean of 2s and 6s, pigeons preferred the key associated with the 6-s and 18-s samples, a result predicted by the single-code/default hypothesis. The pattern of results suggests the need for models that take into account multiple sources of stimulus control. © Society for the Experimental Analysis of Behavior.

miR319, miR390, and miR393 Are Involved in Aluminum Response in Flax (Linum usitatissimum L.).

Science.gov (United States)

Dmitriev, Alexey A; Kudryavtseva, Anna V; Bolsheva, Nadezhda L; Zyablitsin, Alexander V; Rozhmina, Tatiana A; Kishlyan, Natalya V; Krasnov, George S; Speranskaya, Anna S; Krinitsina, Anastasia A; Sadritdinova, Asiya F; Snezhkina, Anastasiya V; Fedorova, Maria S; Yurkevich, Olga Yu; Muravenko, Olga V; Belenikin, Maxim S; Melnikova, Nataliya V

2017-01-01

Acid soils limit agricultural production worldwide. Major reason of crop losses in acid soils is the toxicity of aluminum (Al). In the present work, we investigated expression alterations of microRNAs in flax ( Linum usitatissimum L.) plants under Al stress. Flax seedlings of resistant (TMP1919 and G1071/4_k) and sensitive (Lira and G1071/4_o) to Al cultivars and lines were exposed to AlCl 3 solution for 4 and 24 hours. Twelve small RNA libraries were constructed and sequenced using Illumina platform. In total, 97 microRNAs from 18 conserved families were identified. miR319, miR390, and miR393 revealed expression alterations associated with Al treatment of flax plants. Moreover, for miR390 and miR393, the alterations were distinct in sensitive and resistant to Al genotypes. Expression level changes of miR319 and miR390 were confirmed using qPCR analysis. In flax, potential targets of miR319 are TCPs, miR390-TAS3 and GRF5, and miR393-AFB2-coding transcripts. TCPs, TAS3, GRF5, and AFB2 participate in regulation of plant growth and development. The involvement of miR319, miR390, and miR393 in response to Al stress in flax was shown here for the first time. We speculate that these microRNAs play an important role in Al response via regulation of growth processes in flax plants.

Code Cactus; Code Cactus

Energy Technology Data Exchange (ETDEWEB)

Fajeau, M; Nguyen, L T; Saunier, J [Commissariat a l' Energie Atomique, Centre d' Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette (France)

1966-09-01

This code handles the following problems: -1) Analysis of thermal experiments on a water loop at high or low pressure; steady state or transient behavior; -2) Analysis of thermal and hydrodynamic behavior of water-cooled and moderated reactors, at either high or low pressure, with boiling permitted; fuel elements are assumed to be flat plates: - Flowrate in parallel channels coupled or not by conduction across plates, with conditions of pressure drops or flowrate, variable or not with respect to time is given; the power can be coupled to reactor kinetics calculation or supplied by the code user. The code, containing a schematic representation of safety rod behavior, is a one dimensional, multi-channel code, and has as its complement (FLID), a one-channel, two-dimensional code. (authors) [French] Ce code permet de traiter les problemes ci-dessous: 1. Depouillement d'essais thermiques sur boucle a eau, haute ou basse pression, en regime permanent ou transitoire; 2. Etudes thermiques et hydrauliques de reacteurs a eau, a plaques, a haute ou basse pression, ebullition permise: - repartition entre canaux paralleles, couples on non par conduction a travers plaques, pour des conditions de debit ou de pertes de charge imposees, variables ou non dans le temps; - la puissance peut etre couplee a la neutronique et une representation schematique des actions de securite est prevue. Ce code (Cactus) a une dimension d'espace et plusieurs canaux, a pour complement Flid qui traite l'etude d'un seul canal a deux dimensions. (auteurs)

General features of the neutronics design code EQUICYCLE

International Nuclear Information System (INIS)

Jirlow, K.

1978-10-01

The neutronics code EQUICYCLE has been developed and improved over a long period of time. It is expecially adapted to survey type design calculations of large fast power reactors with particular emphasis on the nuclear parameters for a realistic equilibrium fuel cycle. Thus the code is used to evaluate the breeding performance, the power distributions and the uranium and plutonium mass balance for realistic refuelling schemes. In addition reactivity coefficients can be calculated and the influence of burnup could be assessed. The code is two-dimensional and treats the reactor core in R-Z geometry. The basic ideas of the calculating scheme are successive iterative improvement of cross-section sets and flux spectra and use of the mid-cycle flux for burning the fuel according to a specified refuelling scheme. Normally given peak burn-ups and maximum power densities are used as boundary conditions. The code is capable of handling the unconventional, so called heterogeneous cores. (author)

CRNDE: a long non-coding RNA involved in CanceR, Neurobiology and DEvelopment

Directory of Open Access Journals (Sweden)

Blake C. Ellis

2012-11-01

Full Text Available CRNDE is the gene symbol for Colorectal Neoplasia Differentially Expressed (non protein-coding, a long non-coding RNA (lncRNA gene that expresses multiple splice variants and displays a very tissue-specific pattern of expression. CRNDE was initially identified as a lncRNA whose expression is highly elevated in colorectal cancer, but it is also upregulated in many other solid tumors and in leukemias. Indeed, CRNDE is the most upregulated lncRNA in gliomas and here, as in other cancers, it is associated with a stemness signature. CRNDE is expressed in specific regions within the human and mouse brain; the mouse ortholog is high in induced pluripotent stem cells and increases further during neuronal differentiation. We suggest that CRNDE is a multifunctional lncRNA whose different splice forms provide specific functional scaffolds for regulatory complexes, such as the polycomb repressive complex 2 (PRC2 and CoREST chromatin-modifying complexes, which CRNDE helps pilot to target genes.

PMICALC: an R code-based software for estimating post-mortem interval (PMI) compatible with Windows, Mac and Linux operating systems.

Science.gov (United States)

Muñoz-Barús, José I; Rodríguez-Calvo, María Sol; Suárez-Peñaranda, José M; Vieira, Duarte N; Cadarso-Suárez, Carmen; Febrero-Bande, Manuel

2010-01-30

In legal medicine the correct determination of the time of death is of utmost importance. Recent advances in estimating post-mortem interval (PMI) have made use of vitreous humour chemistry in conjunction with Linear Regression, but the results are questionable. In this paper we present PMICALC, an R code-based freeware package which estimates PMI in cadavers of recent death by measuring the concentrations of potassium ([K+]), hypoxanthine ([Hx]) and urea ([U]) in the vitreous humor using two different regression models: Additive Models (AM) and Support Vector Machine (SVM), which offer more flexibility than the previously used Linear Regression. The results from both models are better than those published to date and can give numerical expression of PMI with confidence intervals and graphic support within 20 min. The program also takes into account the cause of death. 2009 Elsevier Ireland Ltd. All rights reserved.

Isometries and binary images of linear block codes over ℤ4 + uℤ4 and ℤ8 + uℤ8

Science.gov (United States)

Sison, Virgilio; Remillion, Monica

2017-10-01

Let {{{F}}}2 be the binary field and ℤ2 r the residue class ring of integers modulo 2 r , where r is a positive integer. For the finite 16-element commutative local Frobenius non-chain ring ℤ4 + uℤ4, where u is nilpotent of index 2, two weight functions are considered, namely the Lee weight and the homogeneous weight. With the appropriate application of these weights, isometric maps from ℤ4 + uℤ4 to the binary spaces {{{F}}}24 and {{{F}}}28, respectively, are established via the composition of other weight-based isometries. The classical Hamming weight is used on the binary space. The resulting isometries are then applied to linear block codes over ℤ4+ uℤ4 whose images are binary codes of predicted length, which may or may not be linear. Certain lower and upper bounds on the minimum distances of the binary images are also derived in terms of the parameters of the ℤ4 + uℤ4 codes. Several new codes and their images are constructed as illustrative examples. An analogous procedure is performed successfully on the ring ℤ8 + uℤ8, where u 2 = 0, which is a commutative local Frobenius non-chain ring of order 64. It turns out that the method is possible in general for the class of rings ℤ2 r + uℤ2 r , where u 2 = 0, for any positive integer r, using the generalized Gray map from ℤ2 r to {{{F}}}2{2r-1}.

Evaluation Codes from an Affine Veriety Code Perspective

DEFF Research Database (Denmark)

Geil, Hans Olav

2008-01-01

Evaluation codes (also called order domain codes) are traditionally introduced as generalized one-point geometric Goppa codes. In the present paper we will give a new point of view on evaluation codes by introducing them instead as particular nice examples of affine variety codes. Our study...... includes a reformulation of the usual methods to estimate the minimum distances of evaluation codes into the setting of affine variety codes. Finally we describe the connection to the theory of one-pointgeometric Goppa codes. Contents 4.1 Introduction...... . . . . . . . . . . . . . . . . . . . . . . . 171 4.9 Codes form order domains . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173 4.10 One-point geometric Goppa codes . . . . . . . . . . . . . . . . . . . . . . . . 176 4.11 Bibliographical Notes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 178 References...

Long non-coding RNA TUG1 promotes migration and invasion by acting as a ceRNA of miR-335-5p in osteosarcoma cells.

Science.gov (United States)

Wang, Yong; Yang, Tao; Zhang, Zhen; Lu, Ming; Zhao, Wei; Zeng, Xiandong; Zhang, Weiguo

2017-05-01

Long non-coding RNA (lncRNA) have been the focus of increasing attention due to the role they play in many diseases, including osteosarcoma. The function of taurine upregulated gene 1 (TUG1) and its mechanism in osteosarcoma remain unclear. In our research, we found that TUG1 was elevated and correlated with a poor prognosis in osteosarcoma patients. In addition, the following functional experiment showed that decreased TUG1 could remarkably inhibit osteosarcoma cell migration and invasion, indicating that TUG1 functioned as an oncogene in osteosarcoma. Moreover, we revealed that TUG1 and Rho-associated coiled-coil-containing protein kinase 1 (ROCK1), a metastasis-related gene targeted by microRNA-335-5p (miR-335-5p), had the same miR-335-5p combining site. The subsequent luciferase assay verified TUG1 was a target of miR-335-5p. Furthermore, the results of a real-time quantitative PCR showed that TUG1 and miR-335-5p could affect each other's expression. respectively. Finally, we affirmed that TUG1 affected ROCK1 expression and ROCK1-mediated migration/invasion by working as a competitive endogenous RNA (ceRNA) via miR-335-5p. In summary, the findings of this study, based on ceRNA theory, combining the research foundation of miR-335-5p and ROCK1, and taking TUG1 as a new study point, provide new insight into molecular-level reversing migration and invasion of osteosarcoma. © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

Real-time minimal-bit-error probability decoding of convolutional codes

Science.gov (United States)

Lee, L.-N.

1974-01-01

A recursive procedure is derived for decoding of rate R = 1/n binary convolutional codes which minimizes the probability of the individual decoding decisions for each information bit, subject to the constraint that the decoding delay be limited to Delta branches. This new decoding algorithm is similar to, but somewhat more complex than, the Viterbi decoding algorithm. A real-time, i.e., fixed decoding delay, version of the Viterbi algorithm is also developed and used for comparison to the new algorithm on simulated channels. It is shown that the new algorithm offers advantages over Viterbi decoding in soft-decision applications, such as in the inner coding system for concatenated coding.

Real-time minimal bit error probability decoding of convolutional codes

Science.gov (United States)

Lee, L. N.

1973-01-01

A recursive procedure is derived for decoding of rate R=1/n binary convolutional codes which minimizes the probability of the individual decoding decisions for each information bit subject to the constraint that the decoding delay be limited to Delta branches. This new decoding algorithm is similar to, but somewhat more complex than, the Viterbi decoding algorithm. A real-time, i.e. fixed decoding delay, version of the Viterbi algorithm is also developed and used for comparison to the new algorithm on simulated channels. It is shown that the new algorithm offers advantages over Viterbi decoding in soft-decision applications such as in the inner coding system for concatenated coding.

PlayNCool: Opportunistic Network Coding for Local Optimization of Routing in Wireless Mesh Networks

DEFF Research Database (Denmark)

Pahlevani, Peyman; Roetter, Daniel Enrique Lucani; Pedersen, Morten Videbæk

2013-01-01

This paper introduces PlayNCool, an opportunistic protocol with local optimization based on network coding to increase the throughput of a wireless mesh network (WMN). PlayNCool aims to enhance current routing protocols by (i) allowing random linear network coding transmissions end-to-end, (ii) r...

Color differences among feral pigeons (Columba livia) are not attributable to sequence variation in the coding region of the melanocortin-1 receptor gene (MC1R)

Science.gov (United States)

2013-01-01

Background Genetic variation at the melanocortin-1 receptor (MC1R) gene is correlated with melanin color variation in many birds. Feral pigeons (Columba livia) show two major melanin-based colorations: a red coloration due to pheomelanic pigment and a black coloration due to eumelanic pigment. Furthermore, within each color type, feral pigeons display continuous variation in the amount of melanin pigment present in the feathers, with individuals varying from pure white to a full dark melanic color. Coloration is highly heritable and it has been suggested that it is under natural or sexual selection, or both. Our objective was to investigate whether MC1R allelic variants are associated with plumage color in feral pigeons. Findings We sequenced 888 bp of the coding sequence of MC1R among pigeons varying both in the type, eumelanin or pheomelanin, and the amount of melanin in their feathers. We detected 10 non-synonymous substitutions and 2 synonymous substitution but none of them were associated with a plumage type. It remains possible that non-synonymous substitutions that influence coloration are present in the short MC1R fragment that we did not sequence but this seems unlikely because we analyzed the entire functionally important region of the gene. Conclusions Our results show that color differences among feral pigeons are probably not attributable to amino acid variation at the MC1R locus. Therefore, variation in regulatory regions of MC1R or variation in other genes may be responsible for the color polymorphism of feral pigeons. PMID:23915680

Long Non-Coding RNA TUG1 Promotes Proliferation and Inhibits Apoptosis of Osteosarcoma Cells by Sponging miR-132-3p and Upregulating SOX4 Expression.

Science.gov (United States)

Li, Gang; Liu, Keyu; Du, Xinhui

2018-03-01

Long non-coding RNA taurine upregulated gene 1 (TUG1) is reported to be a vital regulator of the progression of various cancers. This study aimed to explore the exact roles and molecular mechanisms of TUG1 in osteosarcoma (OS) development. Real-time quantitative PCR was applied to detect the expressions of TUG1 and microRNA-132-3p (miR-132-3p) in OS tissues and cells. Western blot was performed to measure protein levels of sex determining region Y-box 4 (SOX4). Cell viability was assessed using XTT assay. Cell apoptosis was evaluated using flow cytometry and caspase-3 activity detection assays. Bioinformatics analysis and luciferase reporter experiments were employed to confirm relationships among TUG1, miR-132-3p, and SOX4. TUG1 was highly expressed in human OS tissues, OS cell lines, and primary OS cells. TUG1 knockdown hindered proliferation and induced apoptosis in human OS cell lines and primary OS cells. Moreover, TUG1 inhibited miR-132-3p expression by direct interaction, and introduction of miR-132-3p inhibitor partly abrogated the effect of TUG1 knockdown on the proliferation and apoptosis of OS cells. Furthermore, SOX4 was validated as a target of miR-132-3p. Further functional analyses revealed that miR-132-3p inhibited proliferation and induced apoptosis of OS cells, while this effect was greatly abated following SOX4 overexpression. Moreover, TUG1 knockdown suppressed proliferation and promoted apoptosis by upregulating miR-132-3p and downregulating SOX4 in primary OS cells. TUG1 facilitated proliferation and suppressed apoptosis by regulating the miR-132-3p/SOX4 axis in human OS cell lines and primary OS cells. This finding provides a potential target for OS therapy. © Copyright: Yonsei University College of Medicine 2018

Roles of Non-Coding RNA in Sugarcane-Microbe Interaction.

Science.gov (United States)

Thiebaut, Flávia; Rojas, Cristian A; Grativol, Clícia; Calixto, Edmundo P da R; Motta, Mariana R; Ballesteros, Helkin G F; Peixoto, Barbara; de Lima, Berenice N S; Vieira, Lucas M; Walter, Maria Emilia; de Armas, Elvismary M; Entenza, Júlio O P; Lifschitz, Sergio; Farinelli, Laurent; Hemerly, Adriana S; Ferreira, Paulo C G

2017-12-20

Studies have highlighted the importance of non-coding RNA regulation in plant-microbe interaction. However, the roles of sugarcane microRNAs (miRNAs) in the regulation of disease responses have not been investigated. Firstly, we screened the sRNA transcriptome of sugarcane infected with Acidovorax avenae . Conserved and novel miRNAs were identified. Additionally, small interfering RNAs (siRNAs) were aligned to differentially expressed sequences from the sugarcane transcriptome. Interestingly, many siRNAs aligned to a transcript encoding a copper-transporter gene whose expression was induced in the presence of A. avenae , while the siRNAs were repressed in the presence of A. avenae . Moreover, a long intergenic non-coding RNA was identified as a potential target or decoy of miR408. To extend the bioinformatics analysis, we carried out independent inoculations and the expression patterns of six miRNAs were validated by quantitative reverse transcription-PCR (qRT-PCR). Among these miRNAs, miR408-a copper-microRNA-was downregulated. The cleavage of a putative miR408 target, a laccase, was confirmed by a modified 5'RACE (rapid amplification of cDNA ends) assay. MiR408 was also downregulated in samples infected with other pathogens, but it was upregulated in the presence of a beneficial diazotrophic bacteria. Our results suggest that regulation by miR408 is important in sugarcane sensing whether microorganisms are either pathogenic or beneficial, triggering specific miRNA-mediated regulatory mechanisms accordingly.

Roles of Non-Coding RNA in Sugarcane-Microbe Interaction

Science.gov (United States)

Grativol, Clícia; Motta, Mariana R.; Ballesteros, Helkin G. F.; Peixoto, Barbara; Vieira, Lucas M.; Walter, Maria Emilia; de Armas, Elvismary M.; Entenza, Júlio O. P.; Lifschitz, Sergio; Farinelli, Laurent; Hemerly, Adriana S.

2017-01-01

Studies have highlighted the importance of non-coding RNA regulation in plant-microbe interaction. However, the roles of sugarcane microRNAs (miRNAs) in the regulation of disease responses have not been investigated. Firstly, we screened the sRNA transcriptome of sugarcane infected with Acidovorax avenae. Conserved and novel miRNAs were identified. Additionally, small interfering RNAs (siRNAs) were aligned to differentially expressed sequences from the sugarcane transcriptome. Interestingly, many siRNAs aligned to a transcript encoding a copper-transporter gene whose expression was induced in the presence of A. avenae, while the siRNAs were repressed in the presence of A. avenae. Moreover, a long intergenic non-coding RNA was identified as a potential target or decoy of miR408. To extend the bioinformatics analysis, we carried out independent inoculations and the expression patterns of six miRNAs were validated by quantitative reverse transcription-PCR (qRT-PCR). Among these miRNAs, miR408—a copper-microRNA—was downregulated. The cleavage of a putative miR408 target, a laccase, was confirmed by a modified 5′RACE (rapid amplification of cDNA ends) assay. MiR408 was also downregulated in samples infected with other pathogens, but it was upregulated in the presence of a beneficial diazotrophic bacteria. Our results suggest that regulation by miR408 is important in sugarcane sensing whether microorganisms are either pathogenic or beneficial, triggering specific miRNA-mediated regulatory mechanisms accordingly. PMID:29657296

Roles of Non-Coding RNA in Sugarcane-Microbe Interaction

Directory of Open Access Journals (Sweden)

Flávia Thiebaut

2017-12-01

Full Text Available Studies have highlighted the importance of non-coding RNA regulation in plant-microbe interaction. However, the roles of sugarcane microRNAs (miRNAs in the regulation of disease responses have not been investigated. Firstly, we screened the sRNA transcriptome of sugarcane infected with Acidovorax avenae. Conserved and novel miRNAs were identified. Additionally, small interfering RNAs (siRNAs were aligned to differentially expressed sequences from the sugarcane transcriptome. Interestingly, many siRNAs aligned to a transcript encoding a copper-transporter gene whose expression was induced in the presence of A. avenae, while the siRNAs were repressed in the presence of A. avenae. Moreover, a long intergenic non-coding RNA was identified as a potential target or decoy of miR408. To extend the bioinformatics analysis, we carried out independent inoculations and the expression patterns of six miRNAs were validated by quantitative reverse transcription-PCR (qRT-PCR. Among these miRNAs, miR408—a copper-microRNA—was downregulated. The cleavage of a putative miR408 target, a laccase, was confirmed by a modified 5′RACE (rapid amplification of cDNA ends assay. MiR408 was also downregulated in samples infected with other pathogens, but it was upregulated in the presence of a beneficial diazotrophic bacteria. Our results suggest that regulation by miR408 is important in sugarcane sensing whether microorganisms are either pathogenic or beneficial, triggering specific miRNA-mediated regulatory mechanisms accordingly.

An Optimal Linear Coding for Index Coding Problem

OpenAIRE

Pezeshkpour, Pouya

2015-01-01

An optimal linear coding solution for index coding problem is established. Instead of network coding approach by focus on graph theoric and algebraic methods a linear coding program for solving both unicast and groupcast index coding problem is presented. The coding is proved to be the optimal solution from the linear perspective and can be easily utilize for any number of messages. The importance of this work is lying mostly on the usage of the presented coding in the groupcast index coding ...

A Novel Error Resilient Scheme for Wavelet-based Image Coding Over Packet Networks

OpenAIRE

WenZhu Sun; HongYu Wang; DaXing Qian

2012-01-01

this paper presents a robust transmission strategy for wavelet based scalable bit stream over packet erasure channel. By taking the advantage of the bit plane coding and the multiple description coding, the proposed strategy adopts layered multiple description coding (LMDC) for the embedded wavelet coders to improve the error resistant capability of the important bit planes in the meaning of D(R) function. Then, the post-compression rate-distortion (PCRD) optimization process is used to impro...

Introduction and preparation of the nuclear fuel cycle facility risk analysis code: STAR

International Nuclear Information System (INIS)

Nomura, Yasushi

1990-09-01

STAR code is a computer program, by which one can perform the probabilistic safety assessment (PSA) for the nuclear fuel cycle facility in both the normal and the accidental event of environmental radioactive material release. This code was originally developed by NUKEM GmbH in West Germany as a fruit of the PSE (Projekt Sicherheitsstudien Entsorgung) aiming at R and D of safety analysis methods for use in nuclear fuel cycle facilities such as reprocessing plants. In JAERI, efforts have been made to research and develop safety assessment methods applicable to the accidental situations assumed to happen in the reprocessing plants. In this line of objectives, the STAR code was introduced from NUKEM GmbH in 1986 and, since then, has been improved and prepared to add an ability to analyze public radiation exposure by released activities from the plants. At the first stage of this code preparation, the program conversion was made to adapt the STAR code, originally operative on IBM-compatible PC's and Hewlett Packard 7550A plotters, to NEC PC 9801RX and NEC PR 602R page printers installed in the Fuel Cycle Safety Assessment Laboratory of JAERI. This report describes calculational performances of the STAR code, results of the improvement and preparation works together with input/output data format in illustration of a sample HALW (High Activity Liquid Waste) tank PSA problem, thus making a users' manual for the STAR code. (author)

Probability and statistics with R

CERN Document Server

Ugarte, Maria Dolores; Arnholt, Alan T

2008-01-01

-Technometrics, May 2009, Vol. 51, No. 2 The book is comprehensive and well written. The notation is clear and the mathematical derivations behind nontrivial equations and computational implementations are carefully explained. Rather than presenting a collection of R scripts together with a summary of relevant theoretical results, this book offers a well-balanced mix of theory, examples and R code.-Raquel Prado, University of California, Santa Cruz,  The American Statistician, February 2009… an impressive book … Overall, this is a good reference book with comprehensive coverage of the details

Additional extensions to the NASCAP computer code, volume 3

Science.gov (United States)

Mandell, M. J.; Cooke, D. L.

1981-01-01

The ION computer code is designed to calculate charge exchange ion densities, electric potentials, plasma temperatures, and current densities external to a neutralized ion engine in R-Z geometry. The present version assumes the beam ion current and density to be known and specified, and the neutralizing electrons to originate from a hot-wire ring surrounding the beam orifice. The plasma is treated as being resistive, with an electron relaxation time comparable to the plasma frequency. Together with the thermal and electrical boundary conditions described below and other straightforward engine parameters, these assumptions suffice to determine the required quantities. The ION code, written in ASCII FORTRAN for UNIVAC 1100 series computers, is designed to be run interactively, although it can also be run in batch mode. The input is free-format, and the output is mainly graphical, using the machine-independent graphics developed for the NASCAP code. The executive routine calls the code's major subroutines in user-specified order, and the code allows great latitude for restart and parameter change.

Decision n. 2010-DC-0175 made on the 4. of February 2010 by the Nuclear Safety Authority and defining technical modalities and periodicities of controls as prescribed in the R. 4452-12 and R. 4452-13 articles of the Labour Code as well as in the R. 1333-7 et R. 1333-95 articles of the Public Health Code

International Nuclear Information System (INIS)

2010-01-01

This document defines the modalities of technical controls of sources and equipment emitting ionizing radiation, the modalities of technical controls of the surroundings, the modalities of the control of the efficiency of radioprotection organization and technical equipment (management of sealed and non-sealed radioactive sources, elimination of effluents and wastes associated with these sources), and the modalities of control of measurement instruments and of protection devices, altogether in application of the Labour code and of the Public Health code. Requirements defined by these both codes are recalled in appendix. They may depend on the radioactive source type or on the equipment (electric equipment generating X rays, particle accelerator, sealed sources or equipment containing such sources, not-sealed sources)

Osculating Spaces of Varieties and Linear Network Codes

DEFF Research Database (Denmark)

Hansen, Johan P.

2013-01-01

We present a general theory to obtain good linear network codes utilizing the osculating nature of algebraic varieties. In particular, we obtain from the osculating spaces of Veronese varieties explicit families of equidimensional vector spaces, in which any pair of distinct vector spaces...... intersects in the same dimension. Linear network coding transmits information in terms of a basis of a vector space and the information is received as a basis of a possible altered vector space. Ralf Koetter and Frank R. Kschischang introduced a metric on the set af vector spaces and showed that a minimal...... distance decoder for this metric achieves correct decoding if the dimension of the intersection of the transmitted and received vector space is sufficiently large. The obtained osculating spaces of Veronese varieties are equidistant in the above metric. The parameters of the resulting linear network codes...

Osculating Spaces of Varieties and Linear Network Codes

DEFF Research Database (Denmark)

Hansen, Johan P.

We present a general theory to obtain good linear network codes utilizing the osculating nature of algebraic varieties. In particular, we obtain from the osculating spaces of Veronese varieties explicit families of equideminsional vector spaces, in which any pair of distinct vector spaces...... intersects in the same dimension. Linear network coding transmits information in terms of a basis of a vector space and the information is received as a basis of a possible altered vector space. Ralf Koetter and Frank R. Kschischang introduced a metric on the set af vector spaces and showed that a minimal...... distance decoder for this metric achieves correct decoding if the dimension of the intersection of the transmitted and received vector space is sufficiently large. The obtained osculating spaces of Veronese varieties are equidistant in the above metric. The parameters of the resulting linear network codes...

Novel 2D-sequential color code system employing Image Sensor Communications for Optical Wireless Communications

Directory of Open Access Journals (Sweden)

Trang Nguyen

2016-06-01

Full Text Available The IEEE 802.15.7r1 Optical Wireless Communications Task Group (TG7r1, also known as the revision of the IEEE 802.15.7 Visible Light Communication standard targeting the commercial usage of visible light communication systems, is of interest in this paper. The paper is mainly concerned with Image Sensor Communications (ISC of TG7r1; however, the major challenge facing ISC, as addressed in the Technical Consideration Document (TCD of TG7r1, is Image Sensor Compatibility among the variety of different commercial cameras on the market. One of the most challenging but interesting compatibility requirements is the need to support the verified presence of frame rate variation. This paper proposes a novel design for 2D-sequential color code. Compared to a QR-code-based sequential transmission, the proposed design of 2D-sequential code can overcome the above challenge that it is compatible with different frame rate variations and different shutter operations, and has the ability to mitigate the rolling effect as well as the rotating effect while effectively minimizing transmission overhead. Practical implementations are demonstrated and a performance comparison is presented.

Forms and Linear Network Codes

DEFF Research Database (Denmark)

Hansen, Johan P.

We present a general theory to obtain linear network codes utilizing forms and obtain explicit families of equidimensional vector spaces, in which any pair of distinct vector spaces intersect in the same small dimension. The theory is inspired by the methods of the author utilizing the osculating...... spaces of Veronese varieties. Linear network coding transmits information in terms of a basis of a vector space and the information is received as a basis of a possibly altered vector space. Ralf Koetter and Frank R. Kschischang introduced a metric on the set af vector spaces and showed that a minimal...... distance decoder for this metric achieves correct decoding if the dimension of the intersection of the transmitted and received vector space is sufficiently large. The vector spaces in our construction are equidistant in the above metric and the distance between any pair of vector spaces is large making...

Evaluation of Extended CCSDS Reed-Solomon Codes for Bandwidth efficiency

DEFF Research Database (Denmark)

Andersen, Jakob Dahl; Justesen, Jørn; Larsen, Knud J.

1999-01-01

The present CCSDS recommendation for Telemetry Channel Coding was originally written around twenty years ago. The appearance of the Turbo coding scheme has made an inclusion of this powerful scheme desirable, and thus it becomes natural also to perform a major rewriting of the other part of the r....... Finally, we present advantages and disadvantages by placing the frame synchronizer before and after the Viterbi decoder, and we suggest an option where the attached sync marker is not convolutionally encoded....

AlleleCoder: a PERL script for coding codominant polymorphism data for PCA analysis

Science.gov (United States)

A useful biological interpretation of diploid heterozygotes is in terms of the dose of the common allele (0, 1 or 2 copies). We have developed a PERL script that converts FASTA files into coded spreadsheets suitable for Principal Component Analysis (PCA). In combination with R and R Commander, two- ...

An Investigation of Interrater Reliability for the Rorschach Performance Assessment System (R-PAS) in a Nonpatient U.S. Sample.

Science.gov (United States)

Kivisalu, Trisha M; Lewey, Jennifer H; Shaffer, Thomas W; Canfield, Merle L

2016-01-01

The Rorschach Performance Assessment System (R-PAS) aims to provide an evidence-based approach to administration, coding, and interpretation of the Rorschach Inkblot Method (RIM). R-PAS analyzes individualized communications given by respondents to each card to code a wide pool of possible variables. Due to the large number of possible codes that can be assigned to these responses, it is important to consider the concordance rates among different assessors. This study investigated interrater reliability for R-PAS protocols. Data were analyzed from a nonpatient convenience sample of 50 participants who were recruited through networking, local marketing, and advertising efforts from January 2013 through October 2014. Blind recoding was used and discrepancies between the initial and blind coders' ratings were analyzed for each variable with SPSS yielding percent agreement and intraclass correlation values. Data for Location, Space, Contents, Synthesis, Vague, Pairs, Form Quality, Populars, Determinants, and Cognitive and Thematic codes are presented. Rates of agreement for 1,168 responses were higher for more simplistic coding (e.g., Location), whereas agreement was lower for more complex codes (e.g., Cognitive and Thematic codes). Overall, concordance rates achieved good to excellent agreement. Results suggest R-PAS is an effective method with high interrater reliability supporting its empirical basis.

karyoploteR: an R/Bioconductor package to plot customizable genomes displaying arbitrary data.

Science.gov (United States)

Gel, Bernat; Serra, Eduard

2017-10-01

Data visualization is a crucial tool for data exploration, analysis and interpretation. For the visualization of genomic data there lacks a tool to create customizable non-circular plots of whole genomes from any species. We have developed karyoploteR, an R/Bioconductor package to create linear chromosomal representations of any genome with genomic annotations and experimental data plotted along them. Plot creation process is inspired in R base graphics, with a main function creating karyoplots with no data and multiple additional functions, including custom functions written by the end-user, adding data and other graphical elements. This approach allows the creation of highly customizable plots from arbitrary data with complete freedom on data positioning and representation. karyoploteR is released under Artistic-2.0 License. Source code and documentation are freely available through Bioconductor (http://www.bioconductor.org/packages/karyoploteR) and at the examples and tutorial page at https://bernatgel.github.io/karyoploter_tutorial. bgel@igtp.cat. © The Author(s) 2017. Published by Oxford University Press.

Canadian energy standards : residential energy code requirements

Energy Technology Data Exchange (ETDEWEB)

Cooper, K. [SAR Engineering Ltd., Burnaby, BC (Canada)

2006-09-15

A survey of residential energy code requirements was discussed. New housing is approximately 13 per cent more efficient than housing built 15 years ago, and more stringent energy efficiency requirements in building codes have contributed to decreased energy use and greenhouse gas (GHG) emissions. However, a survey of residential energy codes across Canada has determined that explicit demands for energy efficiency are currently only present in British Columbia (BC), Manitoba, Ontario and Quebec. The survey evaluated more than 4300 single-detached homes built between 2000 and 2005 using data from the EnerGuide for Houses (EGH) database. House area, volume, airtightness and construction characteristics were reviewed to create archetypes for 8 geographic areas. The survey indicated that in Quebec and the Maritimes, 90 per cent of houses comply with ventilation system requirements of the National Building Code, while compliance in the rest of Canada is much lower. Heat recovery ventilation use is predominant in the Atlantic provinces. Direct-vent or condensing furnaces constitute the majority of installed systems in provinces where natural gas is the primary space heating fuel. Details of Insulation levels for walls, double-glazed windows, and building code insulation standards were also reviewed. It was concluded that if R-2000 levels of energy efficiency were applied, total average energy consumption would be reduced by 36 per cent in Canada. 2 tabs.

Numerical simulations of inertial confinement fusion hohlraum with LARED-integration code

International Nuclear Information System (INIS)

Li Jinghong; Li Shuanggui; Zhai Chuanlei

2011-01-01

In the target design of the Inertial Confinement Fusion (ICF) program, it is common practice to apply radiation hydrodynamics code to study the key physical processes happened in ICF process, such as hohlraum physics, radiation drive symmetry, capsule implosion physics in the radiation-drive approach of ICF. Recently, many efforts have been done to develop our 2D integrated simulation capability of laser fusion with a variety of optional physical models and numerical methods. In order to effectively integrate the existing codes and to facilitate the development of new codes, we are developing an object-oriented structured-mesh parallel code-supporting infrastructure, called JASMIN. Based on two-dimensional three-temperature hohlraum physics code LARED-H and two-dimensional multi-group radiative transfer code LARED-R, we develop a new generation two-dimensional laser fusion code under the JASMIN infrastructure, which enable us to simulate the whole process of laser fusion from the laser beams' entrance into the hohlraum to the end of implosion. In this paper, we will give a brief description of our new-generation two-dimensional laser fusion code, named LARED-Integration, especially in its physical models, and present some simulation results of holhraum. (author)

Rate-adaptive BCH codes for distributed source coding

DEFF Research Database (Denmark)

Salmistraro, Matteo; Larsen, Knud J.; Forchhammer, Søren

2013-01-01

This paper considers Bose-Chaudhuri-Hocquenghem (BCH) codes for distributed source coding. A feedback channel is employed to adapt the rate of the code during the decoding process. The focus is on codes with short block lengths for independently coding a binary source X and decoding it given its...... strategies for improving the reliability of the decoded result are analyzed, and methods for estimating the performance are proposed. In the analysis, noiseless feedback and noiseless communication are assumed. Simulation results show that rate-adaptive BCH codes achieve better performance than low...... correlated side information Y. The proposed codes have been analyzed in a high-correlation scenario, where the marginal probability of each symbol, Xi in X, given Y is highly skewed (unbalanced). Rate-adaptive BCH codes are presented and applied to distributed source coding. Adaptive and fixed checking...

Benchmark analyses for EBR-II shutdown heat removal tests SHRT-17 and SHRT-45R

Energy Technology Data Exchange (ETDEWEB)

Mochizuki, Hiroyasu, E-mail: mochizki@u-fukui.ac.jp [Research Institute of Nuclear Engineering, University of Fukui (Japan); Muranaka, Kohmei; Asai, Takayuki [Graduate School of Engineering, University of Fukui (Japan); Rooijen, W.F.G. van, E-mail: rooijen@u-fukui.ac.jp [Research Institute of Nuclear Engineering, University of Fukui (Japan)

2014-08-15

Highlights: • The IAEA EBR-II benchmarks SHRT-17 and SHRT-45R are analyzed with a 1D system code. • The calculated result of SHRT-17 corresponds well to the measured results. • For SHRT-45R ERANOS is used for various core parameters and reactivity coefficients. • SHRT-45R peak temperature is overestimated with the ERANOS feedback coefficients. • The peak temperature is well predicted when the feedback coefficient is reduced. - Abstract: Benchmark problems of several experiments in EBR-II, proposed by ANL and coordinated by the IAEA, are analyzed using the plant system code NETFLOW++ and the neutronics code ERANOS. The SHRT-17 test conducted as a loss-of-flow test is calculated using only the NETFLOW++ code because it is a purely thermal–hydraulic problem. The measured data were made available to the benchmark participants after the results of the blind benchmark calculations were submitted. Our work shows that major parameters of the plant are predicted with good accuracy. The SHRT-45R test, an unprotected loss of flow test is calculated using the NETFLOW++ code with the aid of delayed neutron data and reactivity coefficients calculated by the ERANOS code. These parameters are used in the NETFLOW++ code to perform a semi-coupled analysis of the neutronics – thermal–hydraulic problem. The measured data are compared with our calculated results. In our work, the peak temperature is underestimated, indicating that the reactivity feedback coefficients are too strong. When the reactivity feedback coefficient for thermal expansion is adjusted, good agreement is obtained in general for the calculated plant parameters, with a few exceptions.

Diagonal Eigenvalue Unity (DEU) code for spectral amplitude coding-optical code division multiple access

Science.gov (United States)

Ahmed, Hassan Yousif; Nisar, K. S.

2013-08-01

Code with ideal in-phase cross correlation (CC) and practical code length to support high number of users are required in spectral amplitude coding-optical code division multiple access (SAC-OCDMA) systems. SAC systems are getting more attractive in the field of OCDMA because of its ability to eliminate the influence of multiple access interference (MAI) and also suppress the effect of phase induced intensity noise (PIIN). In this paper, we have proposed new Diagonal Eigenvalue Unity (DEU) code families with ideal in-phase CC based on Jordan block matrix with simple algebraic ways. Four sets of DEU code families based on the code weight W and number of users N for the combination (even, even), (even, odd), (odd, odd) and (odd, even) are constructed. This combination gives DEU code more flexibility in selection of code weight and number of users. These features made this code a compelling candidate for future optical communication systems. Numerical results show that the proposed DEU system outperforms reported codes. In addition, simulation results taken from a commercial optical systems simulator, Virtual Photonic Instrument (VPI™) shown that, using point to multipoint transmission in passive optical network (PON), DEU has better performance and could support long span with high data rate.

List Decoding of Matrix-Product Codes from nested codes: an application to Quasi-Cyclic codes

DEFF Research Database (Denmark)

Hernando, Fernando; Høholdt, Tom; Ruano, Diego

2012-01-01

A list decoding algorithm for matrix-product codes is provided when $C_1,..., C_s$ are nested linear codes and $A$ is a non-singular by columns matrix. We estimate the probability of getting more than one codeword as output when the constituent codes are Reed-Solomon codes. We extend this list...... decoding algorithm for matrix-product codes with polynomial units, which are quasi-cyclic codes. Furthermore, it allows us to consider unique decoding for matrix-product codes with polynomial units....

Coding Partitions

Directory of Open Access Journals (Sweden)

Fabio Burderi

2007-05-01

Full Text Available Motivated by the study of decipherability conditions for codes weaker than Unique Decipherability (UD, we introduce the notion of coding partition. Such a notion generalizes that of UD code and, for codes that are not UD, allows to recover the ``unique decipherability" at the level of the classes of the partition. By tacking into account the natural order between the partitions, we define the characteristic partition of a code X as the finest coding partition of X. This leads to introduce the canonical decomposition of a code in at most one unambiguouscomponent and other (if any totally ambiguouscomponents. In the case the code is finite, we give an algorithm for computing its canonical partition. This, in particular, allows to decide whether a given partition of a finite code X is a coding partition. This last problem is then approached in the case the code is a rational set. We prove its decidability under the hypothesis that the partition contains a finite number of classes and each class is a rational set. Moreover we conjecture that the canonical partition satisfies such a hypothesis. Finally we consider also some relationships between coding partitions and varieties of codes.

Combinatorial neural codes from a mathematical coding theory perspective.

Science.gov (United States)

Curto, Carina; Itskov, Vladimir; Morrison, Katherine; Roth, Zachary; Walker, Judy L

2013-07-01

Shannon's seminal 1948 work gave rise to two distinct areas of research: information theory and mathematical coding theory. While information theory has had a strong influence on theoretical neuroscience, ideas from mathematical coding theory have received considerably less attention. Here we take a new look at combinatorial neural codes from a mathematical coding theory perspective, examining the error correction capabilities of familiar receptive field codes (RF codes). We find, perhaps surprisingly, that the high levels of redundancy present in these codes do not support accurate error correction, although the error-correcting performance of receptive field codes catches up to that of random comparison codes when a small tolerance to error is introduced. However, receptive field codes are good at reflecting distances between represented stimuli, while the random comparison codes are not. We suggest that a compromise in error-correcting capability may be a necessary price to pay for a neural code whose structure serves not only error correction, but must also reflect relationships between stimuli.

Differential expression of miR-139, miR-486 and miR-21 in breast cancer patients sub-classified according to lymph node status

DEFF Research Database (Denmark)

Rask, Lene; Balslev, Eva; Søkilde, Rolf

2014-01-01

PURPOSE: Therapeutic decisions in breast cancer are increasingly guided by prognostic and predictive biomarkers. Non-protein-coding microRNAs (miRNAs) have recently been found to be deregulated in breast cancers and, in addition, to be correlated with several clinico-pathological features. One...... of the most consistently up-regulated miRNAs is miR-21. Here, we specifically searched for differentially expressed miRNAs in high-risk breast cancer patients as compared to low-risk breast cancer patients. In the same patients, we also compared miR-21 expression with the expression of its presumed target...... PTEN. METHODS: Both microarray and RT-qPCR techniques were used to assess miRNA expression levels in lymph node-positive and -negative human invasive ductal carcinoma tissues. Simultaneously, PTEN protein expression levels were assessed using immunohistochemistry. RESULTS: miR-486-5p and miR-139-5p...

LDGM Codes for Channel Coding and Joint Source-Channel Coding of Correlated Sources

Directory of Open Access Journals (Sweden)

Javier Garcia-Frias

2005-05-01

Full Text Available We propose a coding scheme based on the use of systematic linear codes with low-density generator matrix (LDGM codes for channel coding and joint source-channel coding of multiterminal correlated binary sources. In both cases, the structures of the LDGM encoder and decoder are shown, and a concatenated scheme aimed at reducing the error floor is proposed. Several decoding possibilities are investigated, compared, and evaluated. For different types of noisy channels and correlation models, the resulting performance is very close to the theoretical limits.

The Role of Non-­Coding RNA in Plant Stress

KAUST Repository

MacPherson, Cameron R.

2012-12-01

Post-transcriptional gene silencing (PTGS) is a powerful mechanism that can be adapted to genetically modify crop plants. PTGS operates in many plant signaling pathways including those mediating stress responses. Given the small number of miRNAs known, research on the characterization of stress-related micro-RNA (miRNA) and their targets could provide the basis for engineering stress tolerant traits in crops. Indeed, several examples of miRNA mediated crop tolerance have been reported. In the research presented here, we aimed to analyze the role of small non-coding RNA (smRNA) pathways involved in plant stress. In particular, we focused on miRNA-mediated PTGS in phosphate (Pi) starvation. The analysis was split into two research projects. First, to identify potential miRNA targets we began by analyzing the response and recovery of coding and long non-coding RNAs (lncRNA) to Pi starvation in shoot and root. The results obtained were the first genome-wide description of the root’s Pi starvation response and recovery. We found that the root\\'s response involved a widely different set of genes than that of the shoot. In the second research project, the results of the first project were correlated with the responses of miRNA and trans-acting small-interfering RNA (tasiRNA) during Pi starvation. Many miRNA circuits have been predicted before, however, tasiRNA circuits are not as well defined. Therefore, we made use of the double-stranded RNA-binding protein 4 (DRB4) smRNA libraries to enhance our prediction of tasiRNAs. Altogether, we provided evidence to support the following miRNA-mRNA pairs that may function in Pi starvation: IPS1:miR399:PHO2; miR399:RS4; miR399:NF-YA10; miR398:CSD1/2; miR2111:TPS11; miR164:NAC6; miR157:TMO7; miR157:PSB28; RPS2:miR169:IPS2; miR397:LAC2; TAS4:PAP1; NR1:PAP1; and Chr3_1967672:TMO7. In general, we found that non-miR399 related circuits were active only during the root’s recovery from Pi starvation. The functional roles of the genes

Software Certification - Coding, Code, and Coders

Science.gov (United States)

Havelund, Klaus; Holzmann, Gerard J.

2011-01-01

We describe a certification approach for software development that has been adopted at our organization. JPL develops robotic spacecraft for the exploration of the solar system. The flight software that controls these spacecraft is considered to be mission critical. We argue that the goal of a software certification process cannot be the development of "perfect" software, i.e., software that can be formally proven to be correct under all imaginable and unimaginable circumstances. More realistically, the goal is to guarantee a software development process that is conducted by knowledgeable engineers, who follow generally accepted procedures to control known risks, while meeting agreed upon standards of workmanship. We target three specific issues that must be addressed in such a certification procedure: the coding process, the code that is developed, and the skills of the coders. The coding process is driven by standards (e.g., a coding standard) and tools. The code is mechanically checked against the standard with the help of state-of-the-art static source code analyzers. The coders, finally, are certified in on-site training courses that include formal exams.

COUPLED SIMULATION OF GAS COOLED FAST REACTOR FUEL ASSEMBLY WITH NESTLE CODE SYSTEM

Directory of Open Access Journals (Sweden)

Filip Osusky

2018-05-01

Full Text Available The paper is focused on coupled calculation of the Gas Cooled Fast Reactor. The proper modelling of coupled neutronics and thermal-hydraulics is the corner stone for future safety assessment of the control and emergency systems. Nowadays, the system and channel thermal-hydraulic codes are accepted by the national regulatory authorities in European Union for license purposes, therefore the code NESTLE was used for the simulation. The NESTLE code is a coupled multigroup neutron diffusion code with thermal-hydraulic sub-channel code. In the paper, the validation of NESTLE code 5.2.1 installation is presented. The processing of fuel assembly homogeneous parametric cross-section library for NESTLE code simulation is made by the sequence TRITON of SCALE code package system. The simulated case in the NESTLE code is one fuel assembly of GFR2400 concept with reflective boundary condition in radial direction and zero flux boundary condition in axial direction. The results of coupled calculation are presented and are consistent with the GFR2400 study of the GoFastR project.

Development of probabilistic fracture mechanics code PASCAL and user's manual

Energy Technology Data Exchange (ETDEWEB)

Shibata, Katsuyuki; Onizawa, Kunio [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Li, Yinsheng; Kato, Daisuke [Fuji Research Institute Corporation, Tokyo (Japan)

2001-03-01

As a part of the aging and structural integrity research for LWR components, a new PFM (Probabilistic Fracture Mechanics) code PASCAL (PFM Analysis of Structural Components in Aging LWR) has been developed since FY1996. This code evaluates the failure probability of an aged reactor pressure vessel subjected to transient loading such as PTS (Pressurized Thermal Shock). The development of the code has been aimed to improve the accuracy and reliability of analysis by introducing new analysis methodologies and algorithms considering the recent development in the fracture mechanics methodologies and computer performance. The code has some new functions in optimized sampling and cell dividing procedure in stratified Monte Carlo simulation, elastic-plastic fracture criterion of R6 method, extension analysis models in semi-elliptical crack, evaluation of effect of thermal annealing and etc. In addition, an input data generator of temperature and stress distribution time histories was also prepared in the code. Functions and performance of the code have been confirmed based on the verification analyses and some case studies on the influence parameters. The present phase of the development will be completed in FY2000. Thus this report provides the user's manual and theoretical background of the code. (author)

Discussion on LDPC Codes and Uplink Coding

Science.gov (United States)

Andrews, Ken; Divsalar, Dariush; Dolinar, Sam; Moision, Bruce; Hamkins, Jon; Pollara, Fabrizio

2007-01-01

This slide presentation reviews the progress that the workgroup on Low-Density Parity-Check (LDPC) for space link coding. The workgroup is tasked with developing and recommending new error correcting codes for near-Earth, Lunar, and deep space applications. Included in the presentation is a summary of the technical progress of the workgroup. Charts that show the LDPC decoder sensitivity to symbol scaling errors are reviewed, as well as a chart showing the performance of several frame synchronizer algorithms compared to that of some good codes and LDPC decoder tests at ESTL. Also reviewed is a study on Coding, Modulation, and Link Protocol (CMLP), and the recommended codes. A design for the Pseudo-Randomizer with LDPC Decoder and CRC is also reviewed. A chart that summarizes the three proposed coding systems is also presented.

Determination of the number of copies of genes coding for 5s-rRNA and tRNA in the genomes of 43 species of wheat and Aegilops

International Nuclear Information System (INIS)

Vakhitov, V.A.; Gimalov, F.R.; Nikonorov, Yu.M.

1986-01-01

The number of 5s-rRNA and tRNA genes has been studied in 43 species of wheat and Aegilops differing in ploidy level, genomic composition and origin. It has been demonstrated that the repeatability of the 5s-rRNA and tRNA genes increases in wheat with increasing ploidy level, but not in proportion to the genome size. In Aegilops, in distinction from wheat, the relative as well as absolute number of 5s-RNA genes increases with increasing ploidy level. The proportion of the sequences coding for tRNA in the dipoloid and polyploid Aegilops species is practically similar, while the number of tRNA genes increases almost 2-3 times with increasing ploidy level. Large variability has been recorded between the species with similar genomic composition and ploidy level in respect of the number of the 5s-rRNA and tRNA genes. It has been demonstrated that integration of the initial genomes of the amphidiploids is accompanied by elimination of a particular part of these genomes. It has been concluded that the mechanisms of establishment and evolution of genomes in the intra- and intergeneric allopolyploids are not identical

Non-coding RNA may be associated with cytoplasmic male sterility in Silene vulgaris

Czech Academy of Sciences Publication Activity Database

Stone, James D.; Koloušková, Pavla; Sloan, D.B.; Štorchová, Helena

2017-01-01

Roč. 68, č. 7 (2017), s. 1599-1612 ISSN 0022-0957 R&D Projects: GA ČR(CZ) GA16-09220S Institutional support: RVO:61389030 Keywords : Cytoplasmic male sterility * Editing * Mitochondrion * Non-coding RNA * Silene vulgaris * Splicing * Transcriptome Subject RIV: EF - Botanics OBOR OECD: Plant sciences, botany Impact factor: 5.830, year: 2016

Spatial modelling with R-INLA: A review

KAUST Repository

Bakka, Haakon; Rue, Haavard; Fuglstad, Geir-Arne; Riebler, Andrea; Bolin, David; Krainski, Elias; Simpson, Daniel; Lindgren, Finn

2018-01-01

Coming up with Bayesian models for spatial data is easy, but performing inference with them can be challenging. Writing fast inference code for a complex spatial model with realistically-sized datasets from scratch is time-consuming, and if changes are made to the model, there is little guarantee that the code performs well. The key advantages of R-INLA are the ease with which complex models can be created and modified, without the need to write complex code, and the speed at which inference can be done even for spatial problems with hundreds of thousands of observations. R-INLA handles latent Gaussian models, where fixed effects, structured and unstructured Gaussian random effects are combined linearly in a linear predictor, and the elements of the linear predictor are observed through one or more likelihoods. The structured random effects can be both standard areal model such as the Besag and the BYM models, and geostatistical models from a subset of the Mat\\'ern Gaussian random fields. In this review, we discuss the large success of spatial modelling with R-INLA and the types of spatial models that can be fitted, we give an overview of recent developments for areal models, and we give an overview of the stochastic partial differential equation (SPDE) approach and some of the ways it can be extended beyond the assumptions of isotropy and separability. In particular, we describe how slight changes to the SPDE approach leads to straight-forward approaches for non-stationary spatial models and non-separable space-time models.

Spatial modelling with R-INLA: A review

KAUST Repository

Bakka, Haakon

2018-02-18

Coming up with Bayesian models for spatial data is easy, but performing inference with them can be challenging. Writing fast inference code for a complex spatial model with realistically-sized datasets from scratch is time-consuming, and if changes are made to the model, there is little guarantee that the code performs well. The key advantages of R-INLA are the ease with which complex models can be created and modified, without the need to write complex code, and the speed at which inference can be done even for spatial problems with hundreds of thousands of observations. R-INLA handles latent Gaussian models, where fixed effects, structured and unstructured Gaussian random effects are combined linearly in a linear predictor, and the elements of the linear predictor are observed through one or more likelihoods. The structured random effects can be both standard areal model such as the Besag and the BYM models, and geostatistical models from a subset of the Mat\\\\\\'ern Gaussian random fields. In this review, we discuss the large success of spatial modelling with R-INLA and the types of spatial models that can be fitted, we give an overview of recent developments for areal models, and we give an overview of the stochastic partial differential equation (SPDE) approach and some of the ways it can be extended beyond the assumptions of isotropy and separability. In particular, we describe how slight changes to the SPDE approach leads to straight-forward approaches for non-stationary spatial models and non-separable space-time models.

Statistical Data Processing with R – Metadata Driven Approach

Directory of Open Access Journals (Sweden)

Rudi SELJAK

2016-06-01

Full Text Available In recent years the Statistical Office of the Republic of Slovenia has put a lot of effort into re-designing its statistical process. We replaced the classical stove-pipe oriented production system with general software solutions, based on the metadata driven approach. This means that one general program code, which is parametrized with process metadata, is used for data processing for a particular survey. Currently, the general program code is entirely based on SAS macros, but in the future we would like to explore how successfully statistical software R can be used for this approach. Paper describes the metadata driven principle for data validation, generic software solution and main issues connected with the use of statistical software R for this approach.

SignalR real-time application cookbook

CERN Document Server

Vespa, Roberto

2014-01-01

This book contains illustrated code examples to help you create real-time, asynchronous, and bi-directional client-server applications. Each recipe will concentrate on one specific aspect of application development with SignalR showing you how that aspect can be used proficiently. Different levels of developers will find this book useful. Beginners will be able to learn all the fundamental concepts of SignalR, quickly becoming productive in a difficult arena. Experienced programmers will find in this book a handy and useful collection of ready-made solutions to common use cases, which they wil

Ion implantation range and energy deposition codes COREL, RASE4, and DAMG2

International Nuclear Information System (INIS)

Brice, D.K.

1977-07-01

The FORTRAN codes COREL, RASE4 and DAMG2 can be used to calculate quantities associated with ion implantation range and energy deposition distributions within an amorphous target, or for ions incident far from low index directions and planes in crystalline targets. RASE4 calculates the projected range, R/sub p/, the root mean square spread in the projected range, ΔR/sub p/, and the root mean square spread of the distribution perpendicular to the projected range ΔR/sub perpendicular to/. These parameters are calculated as a function of incident ion energy, E, and the instantaneous energy of the ion, E'. They are sufficient to determine the three dimensional spatial distribution of the ions in the target in the Gaussian approximation when the depth distribution is independent of the lateral distribution. RASE4 can perform these calculations for targets having up to four different component atomic species. The code COREL is a short, economical version of RASE4 which calculates the range and straggling variables for E' = 0. Its primary use in the present package is to provide the average range and straggling variables for recoiling target atoms which are created by the incident ion. This information is used by RASE4 in calculating the redistribution of deposited energy by the target atom recoils. The code DAMG2 uses the output from RASE4 to calculate the depth distribution of energy deposition into either atomic processes or electronic processes. With other input DAMG2 can be used to calculate the depth distribution of any energy dependent interaction between the incident ions and target atoms. This report documents the basic theory behind COREL, RASE4 and DAMG2, including a description of codes, listings, and complete instructions for using the codes, and their limitations

Preparing diagnostic data for the SNAP transport code

International Nuclear Information System (INIS)

Murphy, J.A.; Scott, S.D.; Towner, H.H.

1992-01-01

This paper describes the program SNAPIN which is used to prepare data for transport analysis with the SNAP code. The data input to SNAP includes diagnostic profiles [n e (R), T e (R), T i (R), v φ (R), Z eff (R), P rad (R)] and measurements such as total plasma current, R major , beam power, gas puff rate, etc. SNAPIN reads in the necessary TFTR data, allows editing of that data, including graphical editing of profile data and the selection of physics models. SNAPIN allows comparison of profile data from all diagnostics that measure a quantity, for example, electron temperature profiles from Thomson scattering and electron cyclotron emission (ECE). A powerful user interface is important to help the user prepare input data sets quickly and consistently, because hundreds of variables must be specified for each analysis. SNAPIN facilitates this by a careful organization of menus, display of all scalar data and switch settings within the menus, the graphical editing and comparison of profiles, and step-by-step checking for consistent physics controls [J. Murphy, S. Scott, and H. Towner, The SNAP User's Guide, Technical Report PPPL-TM-393, Princeton Plasma Physics Laboratory (1992)

New quantum codes constructed from quaternary BCH codes

Science.gov (United States)

Xu, Gen; Li, Ruihu; Guo, Luobin; Ma, Yuena

2016-10-01

In this paper, we firstly study construction of new quantum error-correcting codes (QECCs) from three classes of quaternary imprimitive BCH codes. As a result, the improved maximal designed distance of these narrow-sense imprimitive Hermitian dual-containing quaternary BCH codes are determined to be much larger than the result given according to Aly et al. (IEEE Trans Inf Theory 53:1183-1188, 2007) for each different code length. Thus, families of new QECCs are newly obtained, and the constructed QECCs have larger distance than those in the previous literature. Secondly, we apply a combinatorial construction to the imprimitive BCH codes with their corresponding primitive counterpart and construct many new linear quantum codes with good parameters, some of which have parameters exceeding the finite Gilbert-Varshamov bound for linear quantum codes.

Long non-coding RNA TUG1 promotes cell proliferation and metastasis by negatively regulating miR-300 in gallbladder carcinoma.

Science.gov (United States)

Ma, Fei; Wang, Shou-Hua; Cai, Qiang; Jin, Long-Yang; Zhou, Di; Ding, Jun; Quan, Zhi-Wei

2017-04-01

As we all know, long non-coding RNAs (lncRNAs) have been reported to play vital roles in various human cancers. In this study, we aimed to explore the role of lncRNA TUG1 in gallbladder carcinoma (GBC) development. Total RNA was extracted from the tissues of thirty GBC patients, four GBC cell lines. We detected the expression levels of TUG1 using quantitative real-time PCR. We performed CCK8, colony formation, transwell invasion and apoptosis assays to study the effects of TUG1 on GBC cell proliferation and invasion. Western blot assay was performed to assess to the expression level of epithelial-mesenchymal transition (EMT) markers in transforming growth factor-β1 (TGF-β1) treated and TUG1 knockdown GBC cell. Lastly, dual-luciferase reporter assay and quantitative real-time PCR were performed to verify the potential target microRNAs (miRNAs) of TUG1. TUG1 expression was significantly overexpressed in GBC tissues. Functionally, this study demonstrated that knockdown of TUG1 significantly inhibited GBC cell proliferation, metastasis. Mechanically, we found that TUG1 is upregulated by TGF-β1, and knockdown of TUG1 inhibited GBC cell EMT. Furthermore, we identified that miR-300, which has been reported as a suppressor in other types of cancer, is negatively regulated by TUG1. LncRNA TUG1 promotes GBC cell proliferation, metastasis and EMT progression by functioning as a miRNA sponge to abrogate the endogenous effect of miR-300. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Political analysis using R

CERN Document Server

Monogan III, James E

2015-01-01

Political Analysis Using R can serve as a textbook for undergraduate or graduate students as well as a manual for independent researchers. It is unique among competitor books in its usage of 21 example datasets that are all drawn from political research. All of the data and example code is available from the Springer website, as well as from Dataverse (http://dx.doi.org/10.7910/DVN/ARKOTI). The book provides a narrative of how R can be useful for addressing problems common to the analysis of public administration, public policy, and political science data specifically, in addition to the social sciences more broadly. While the book uses data drawn from political science, public administration, and policy analyses, it is written so that students and researchers in other fields should find it accessible and useful as well. Political Analysis Using R is perfect for the first-time R user who has no prior knowledge about the program. By working through the first seven chapters of this book, an entry-level user sho...

The role of non-coding RNAs in cytoplasmic male sterility in flowering plants

Czech Academy of Sciences Publication Activity Database

Štorchová, Helena

2017-01-01

Roč. 18, č. 11 (2017), č. článku 2429. E-ISSN 1422-0067 R&D Projects: GA ČR GA16-09220S Institutional support: RVO:61389030 Keywords : Cytoplasmic male sterility * Gene expression * Global transcriptome * Non-coding RNA * Pollen development Subject RIV: EF - Botanics OBOR OECD: Plant sciences, botany Impact factor: 3.226, year: 2016

An upper bound for codes for the noisy two-access binary adder channel

NARCIS (Netherlands)

Tilborg, van H.C.A.

1986-01-01

Using earlier methods a combinatorial upper bound is derived for|C|. cdot |D|, where(C,D)is adelta-decodable code pair for the noisy two-access binary adder channel. Asymptotically, this bound reduces toR_{1}=R_{2} leq frac{3}{2} + elog_{2} e - (frac{1}{2} + e) log_{2} (1 + 2e)= frac{1}{2} - e +

Entanglement-assisted quantum MDS codes from negacyclic codes

Science.gov (United States)

Lu, Liangdong; Li, Ruihu; Guo, Luobin; Ma, Yuena; Liu, Yang

2018-03-01

The entanglement-assisted formalism generalizes the standard stabilizer formalism, which can transform arbitrary classical linear codes into entanglement-assisted quantum error-correcting codes (EAQECCs) by using pre-shared entanglement between the sender and the receiver. In this work, we construct six classes of q-ary entanglement-assisted quantum MDS (EAQMDS) codes based on classical negacyclic MDS codes by exploiting two or more pre-shared maximally entangled states. We show that two of these six classes q-ary EAQMDS have minimum distance more larger than q+1. Most of these q-ary EAQMDS codes are new in the sense that their parameters are not covered by the codes available in the literature.

Visualizing code and coverage changes for code review

NARCIS (Netherlands)

Oosterwaal, Sebastiaan; van Deursen, A.; De Souza Coelho, R.; Sawant, A.A.; Bacchelli, A.

2016-01-01

One of the tasks of reviewers is to verify that code modifications are well tested. However, current tools offer little support in understanding precisely how changes to the code relate to changes to the tests. In particular, it is hard to see whether (modified) test code covers the changed code.

Homological stabilizer codes

Energy Technology Data Exchange (ETDEWEB)

Anderson, Jonas T., E-mail: jonastyleranderson@gmail.com

2013-03-15

In this paper we define homological stabilizer codes on qubits which encompass codes such as Kitaev's toric code and the topological color codes. These codes are defined solely by the graphs they reside on. This feature allows us to use properties of topological graph theory to determine the graphs which are suitable as homological stabilizer codes. We then show that all toric codes are equivalent to homological stabilizer codes on 4-valent graphs. We show that the topological color codes and toric codes correspond to two distinct classes of graphs. We define the notion of label set equivalencies and show that under a small set of constraints the only homological stabilizer codes without local logical operators are equivalent to Kitaev's toric code or to the topological color codes. - Highlights: Black-Right-Pointing-Pointer We show that Kitaev's toric codes are equivalent to homological stabilizer codes on 4-valent graphs. Black-Right-Pointing-Pointer We show that toric codes and color codes correspond to homological stabilizer codes on distinct graphs. Black-Right-Pointing-Pointer We find and classify all 2D homological stabilizer codes. Black-Right-Pointing-Pointer We find optimal codes among the homological stabilizer codes.

Therapeutic targeting of non-coding RNAs in cancer

Czech Academy of Sciences Publication Activity Database

Slabý, O.; Laga, Richard; Sedláček, Ondřej

2017-01-01

Roč. 474, č. 24 (2017), s. 4219-4251 ISSN 0264-6021 R&D Projects: GA MŠk(CZ) LQ1604; GA MŠk(CZ) ED1.1.00/02.0109 Institutional support: RVO:61389013 Keywords : non-coding RNA * RNA delivery * polymer carriers Subject RIV: EB - Genetics ; Molecular Biology OBOR OECD: Biochemical research methods Impact factor: 3.797, year: 2016

SPECTRAL AMPLITUDE CODING OCDMA SYSTEMS USING ENHANCED DOUBLE WEIGHT CODE

Directory of Open Access Journals (Sweden)

F.N. HASOON

2006-12-01

Full Text Available A new code structure for spectral amplitude coding optical code division multiple access systems based on double weight (DW code families is proposed. The DW has a fixed weight of two. Enhanced double-weight (EDW code is another variation of a DW code family that can has a variable weight greater than one. The EDW code possesses ideal cross-correlation properties and exists for every natural number n. A much better performance can be provided by using the EDW code compared to the existing code such as Hadamard and Modified Frequency-Hopping (MFH codes. It has been observed that theoretical analysis and simulation for EDW is much better performance compared to Hadamard and Modified Frequency-Hopping (MFH codes.

Microsimulation Modeling for Health Decision Sciences Using R: A Tutorial.

Science.gov (United States)

Krijkamp, Eline M; Alarid-Escudero, Fernando; Enns, Eva A; Jalal, Hawre J; Hunink, M G Myriam; Pechlivanoglou, Petros

2018-04-01

Microsimulation models are becoming increasingly common in the field of decision modeling for health. Because microsimulation models are computationally more demanding than traditional Markov cohort models, the use of computer programming languages in their development has become more common. R is a programming language that has gained recognition within the field of decision modeling. It has the capacity to perform microsimulation models more efficiently than software commonly used for decision modeling, incorporate statistical analyses within decision models, and produce more transparent models and reproducible results. However, no clear guidance for the implementation of microsimulation models in R exists. In this tutorial, we provide a step-by-step guide to build microsimulation models in R and illustrate the use of this guide on a simple, but transferable, hypothetical decision problem. We guide the reader through the necessary steps and provide generic R code that is flexible and can be adapted for other models. We also show how this code can be extended to address more complex model structures and provide an efficient microsimulation approach that relies on vectorization solutions.

Input modelling of ASSERT-PV V2R8M1 for RUFIC fuel bundle

Energy Technology Data Exchange (ETDEWEB)

Park, Joo Hwan; Suk, Ho Chun

2001-02-01

This report describes the input modelling for subchannel analysis of CANFLEX-RU (RUFIC) fuel bundle which has been developed for an advanced fuel bundle of CANDU-6 reactor, using ASSERT-PV V2R8M1 code. Execution file of ASSERT-PV V2R8M1 code was recently transferred from AECL under JRDC agreement between KAERI and AECL. SSERT-PV V2R8M1 which is quite different from COBRA-IV-i code has been developed for thermalhydraulic analysis of CANDU-6 fuel channel by subchannel analysis method and updated so that 43-element CANDU fuel geometry can be applied. Hence, ASSERT code can be applied to the subchannel analysis of RUFIC fuel bundle. The present report was prepared for ASSERT input modelling of RUFIC fuel bundle. Since the ASSERT results highly depend on user's input modelling, the calculation results may be quite different among the user's input models. The objective of the present report is the preparation of detail description of the background information for input data and gives credibility of the calculation results.

Input modelling of ASSERT-PV V2R8M1 for RUFIC fuel bundle

International Nuclear Information System (INIS)

Park, Joo Hwan; Suk, Ho Chun

2001-02-01

This report describes the input modelling for subchannel analysis of CANFLEX-RU (RUFIC) fuel bundle which has been developed for an advanced fuel bundle of CANDU-6 reactor, using ASSERT-PV V2R8M1 code. Execution file of ASSERT-PV V2R8M1 code was recently transferred from AECL under JRDC agreement between KAERI and AECL. SSERT-PV V2R8M1 which is quite different from COBRA-IV-i code has been developed for thermalhydraulic analysis of CANDU-6 fuel channel by subchannel analysis method and updated so that 43-element CANDU fuel geometry can be applied. Hence, ASSERT code can be applied to the subchannel analysis of RUFIC fuel bundle. The present report was prepared for ASSERT input modelling of RUFIC fuel bundle. Since the ASSERT results highly depend on user's input modelling, the calculation results may be quite different among the user's input models. The objective of the present report is the preparation of detail description of the background information for input data and gives credibility of the calculation results

Overview of IRSN R and D activities on severe accidents

International Nuclear Information System (INIS)

Chaumont, B.; Raimond, E.; Dorsselaere, J.P. Van; Simondi-Teisseire, B.

2009-01-01

IRSN activities on SA include safety assessment for existing and future nuclear power plants and experimental reactors, level 2 Probabilistic Safety Assessment (PSA), development of simulation codes and realization of experiments. R and D concerns the following phenomena: fission products behaviour, in particular iodine and ruthenium chemistry (CHIP and EPICUR experiments); core melting and reflooding of damaged cores (MOZART, BECARRE and PEARL experiments); Molten-Core-Concrete-Interaction; thermo-mechanical behaviour of the reactor coolant system and the vessel; direct containment heating, steam explosion; hydrogen distribution and combustion in containment. Other activities concern integration of knowledge into SA codes, validation of the codes, and benchmarking activities. The main codes developed at IRSN are the ASTEC integral code and the detailed codes such as M3CD for fuel coolant interaction and TONUS for hydrogen risk assessment. One essential application of the SA codes is the systematic analysis of the different possible scenarios in the frame of the development of level 2 PSA. (authors)

Electronic applications for the CFQ-R scoring

DEFF Research Database (Denmark)

Ronit, Andreas; Gelpi, Marco; Argentiero, Jonathan

2017-01-01

Patient reported outcomes (PROs) have become widely accepted outcome measures in cystic fibrosis (CF) and other respiratory diseases. The Cystic Fibrosis-Questionnaire-Revised (CFQ-R) is the best validated and most widely used PRO for CF. Data collection can be time-intensive, and electronic plat......, score and save CFQ-R data for all versions. All codes are open access, which will enable other PRO users to design similar applications for other respiratory diseases, such as primary ciliary dyskinesia and non-CF bronchiectasis....

Free-space optical code-division multiple-access system design

Science.gov (United States)

Jeromin, Lori L.; Kaufmann, John E.; Bucher, Edward A.

1993-08-01

This paper describes an optical direct-detection multiple access communications system for free-space satellite networks utilizing code-division multiple-access (CDMA) and forward error correction (FEC) coding. System performance is characterized by how many simultaneous users operating at data rate R can be accommodated in a signaling bandwidth W. The performance of two CDMA schemes, optical orthogonal codes (OOC) with FEC and orthogonal convolutional codes (OCC), is calculated and compared to information-theoretic capacity bounds. The calculations include the effects of background and detector noise as well as nonzero transmitter extinction ratio and power imbalance among users. A system design for 10 kbps multiple-access communications between low-earth orbit satellites is given. With near- term receiver technology and representative system losses, a 15 W peak-power transmitter provides 10-6 BER performance with seven interfering users and full moon background in the receiver FOV. The receiver employs an array of discrete wide-area avalanche photodiodes (APD) for wide field of view coverage. Issues of user acquisition and synchronization, implementation technology, and system scalability are also discussed.

Preparation of functions of computer code GENGTC and improvement for two-dimensional heat transfer calculations for irradiation capsules

International Nuclear Information System (INIS)

Nomura, Yasushi; Someya, Hiroyuki; Ito, Haruhiko.

1992-11-01

Capsules for irradiation tests in the JMTR (Japan Materials Testing Reactor), consist of irradiation specimens surrounded by a cladding tube, holders, an inner tube and a container tube (from 30mm to 65mm in diameter). And the annular gaps between these structural materials in the capsule are filled with liquids or gases. Cooling of the capsule is done by reactor primary coolant flowing down outside the capsule. Most of the heat generated by fission in fuel specimens and gamma absorption in structural materials is directed radially to the capsule container outer surface. In thermal performance calculations for capsule design, an one(r)-dimensional heat transfer computer code entitled (Generalyzed Gap Temperature Calculation), GENGTC, originally developed in Oak Ridge National Laboratory, U.S.A., has been frequently used. In designing a capsule, are needed many cases of parametric calculations with respect to changes materials and gap sizes. And in some cases, two(r,z)-dimensional heat transfer calculations are needed for irradiation test capsules with short length fuel rods. Recently the authors improved the original one-dimensional code GENGTC, (1) to simplify preparation of input data, (2) to perform automatic calculations for parametric survey based on design temperatures, ect. Moreover, the computer code has been improved to perform r-z two-dimensional heat transfer calculation. This report describes contents of the preparation of the one-dimensional code GENGTC and the improvement for the two-dimensional code GENGTC-2, together with their code manuals. (author)

Long non-coding RNA TUG1 contributes to tumorigenesis of human osteosarcoma by sponging miR-9-5p and regulating POU2F1 expression.

Science.gov (United States)

Xie, Chu-Hai; Cao, Yan-Ming; Huang, Yan; Shi, Qun-Wei; Guo, Jian-Hong; Fan, Zi-Wen; Li, Ju-Gen; Chen, Bin-Wei; Wu, Bo-Yi

2016-11-01

Recent studies have shown that long non-coding RNAs (lncRNAs) have critical roles in tumorigenesis, including osteosarcoma. The lncRNA taurine-upregulated gene 1 (TUG1) was reported to be involved in the progression of osteosarcoma. Here, we investigated the role of TUG1 in osteosarcoma cells and the underlying mechanism. TUG1 expression was measured in osteosarcoma cell lines and human normal osteoblast cells by quantitative real-time PCR (qRT-PCR). The effects of TUG1 on osteosarcoma cells were studied by RNA interference in vitro and in vivo. The mechanism of competing endogenous RNA (ceRNA) was determined using bioinformatic analysis and luciferase assays. Our data showed that TUG1 knockdown inhibited cell proliferation and colony formation, and induced G0/G1 cell cycle arrest and apoptosis in vitro, and suppressed tumor growth in vivo. Besides, we found that TUG1 acted as an endogenous sponge to directly bind to miR-9-5p and downregulated miR-9-5p expression. Moreover, TUG1 overturned the effect of miR-9-5p on the proliferation, colony formation, cell cycle arrest, and apoptosis in osteosarcoma cells, which involved the derepression of POU class 2 homeobox 1 (POU2F1) expression. In conclusion, our study elucidated a novel TUG1/miR-9-5p/POU2F1 pathway, in which TUG1 acted as a ceRNA by sponging miR-9-5p, leading to downregulation of POU2F1 and facilitating the tumorigenesis of osteosarcoma. These findings may contribute to the lncRNA-targeted therapy for human osteosarcoma.

Calculation of static harmonics of a nuclear reactor using CITATION code

International Nuclear Information System (INIS)

Belchior Junior, A.; Moreira, J.M.L.

1989-01-01

The CITATION code, which solves the multigroup diffusion equation by the finite difference method, calculates the fundamental λ-mode (harmonic) for nuclear reactors. In this work, two fission source correction methods are attempted to obtain higher λ-modes through the CITATION code. The two methods are compared, their advantages and disadvantages analysed and verified against analytical solutions. Two dimensional harmonic modes are calculated for the IEA-R1 research reactor and for the ANGRA-I power reactor. The results are shown in graphics and tables. (author) [pt

Swiss Foundation Code 2015 principes et recommandations pour la constitution et la conduite des fondations donatrices

CERN Document Server

Sprecher, Thomas; Schnurbein, Georg von

2015-01-01

L’ouvrage «Swiss Foundation Code» propose des directives de gouvernance tenant compte des exigences de la pratique et visant une gestion moderne et professionnelle des fondations d’utilité publique. Les thèmes abordés sont la constitution, l’organisation, la gestion et la surveillance des fondations, leur activité de soutien ainsi que leur politique financière et de placement. Sur la nouvelle édition: Par rapport au Swiss Foundation Code 2009, la présente édition propose un approfondissement de la thématique en général ainsi qu’une refonte complète de certains sujets, notamment ceux concernant les finances (placement de fortune, règlement des rapports avec les prestataires financiers) ou les conflits d’intérêts. Sur le contenu: Le Code contient trois principes (réalisation du but de la fondation, checks and balances, transparence), des recommandations (en lien avec la constitution, la gestion, le soutien et les finances), ainsi que des explications et des conseils applicables à ...

Dynamics of r.f. production of Stellarator plasmas in the ion cyclotron range of frequency

International Nuclear Information System (INIS)

Moiseenko, V.E.; Lysoivan, A.I.; Kasilov, S.V.; Plyusnin, V.V.

1995-01-01

The present study investigated numerically the process of r.f. production of plasma in the URAGAN-3M torsatron in the frequency range below the ion cyclotron frequency (ω ci ). The dynamics of r.f. plasma build-up at the stages of neutral gas burnout and plasma heating were studied using a zero-dimensional transport code, in which the plasma confinement law was determined by large helical device scaling. Two models for input r.f. power were used. In the first case, the r.f. power absorbed by the electrons was computed by a one-dimensional r.f. code solving Maxwell's boundary problem equations. The mechanisms of electron heating through direct excitation of the slow wave (SW) by antennae as well as the conversion of fast wave (FW) into SW in the vicinity of Alfven resonance (scenario of Alfven heating) were taken into account in the computations. In the second case, an 'ideal' model of r.f. power deposition onto the electrons as a linear function of plasma density was employed. A noticeable difference in plasma production dynamics computed for these two cases was found. Better agreement with experimental data obtained from the URAGAN-3M torsatron was found for the first case resulting from combination of the one-dimensional r.f. and zero-dimensional transport codes. ((orig.))

Unfolding code for neutron spectrometry based on neural nets technology

International Nuclear Information System (INIS)

Ortiz R, J. M.; Vega C, H. R.

2012-10-01

The most delicate part of neutron spectrometry, is the unfolding process. The derivation of the spectral information is not simple because the unknown is not given directly as a result of the measurements. The drawbacks associated with traditional unfolding procedures have motivated the need of complementary approaches. Novel methods based on Artificial Neural Networks have been widely investigated. In this work, a neutron spectrum unfolding code based on neural nets technology is presented. This unfolding code called Neutron Spectrometry and Dosimetry by means of Artificial Neural Networks was designed in a graphical interface under LabVIEW programming environment. The core of the code is an embedded neural network architecture, previously optimized by the R obust Design of Artificial Neural Networks Methodology . The main features of the code are: is easy to use, friendly and intuitive to the user. This code was designed for a Bonner Sphere System based on a 6 Lil(Eu) neutron detector and a response matrix expressed in 60 energy bins taken from an International Atomic Energy Agency compilation. The main feature of the code is that as entrance data, only seven rate counts measurement with a Bonner spheres spectrometer are required for simultaneously unfold the 60 energy bins of the neutron spectrum and to calculate 15 dosimetric quantities, for radiation protection porpoises. This code generates a full report in html format with all relevant information. (Author)

Variables associated with Grade R English Additional Language ...

African Journals Online (AJOL)

reviewer 1

Since Grade R is the foundation for formal Grade 1 learning, research conducted ... There appears to be a paucity of research on variables relating to EAL acquisition in South Africa. In a ...... teacher can code switch and explain the meaning of.

Constraint propagation equations of the 3+1 decomposition of f(R) gravity

International Nuclear Information System (INIS)

Paschalidis, Vasileios; Shapiro, Stuart L; Halataei, Seyyed M H; Sawicki, Ignacy

2011-01-01

Theories of gravity other than general relativity (GR) can explain the observed cosmic acceleration without a cosmological constant. One such class of theories of gravity is f(R). Metric f(R) theories have been proven to be equivalent to Brans-Dicke (BD) scalar-tensor gravity without a kinetic term (ω = 0). Using this equivalence and a 3+1 decomposition of the theory, it has been shown that metric f(R) gravity admits a well-posed initial value problem. However, it has not been proven that the 3+1 evolution equations of metric f(R) gravity preserve the (Hamiltonian and momentum) constraints. In this paper, we show that this is indeed the case. In addition, we show that the mathematical form of the constraint propagation equations in BD-equilavent f(R) gravity and in f(R) gravity in both the Jordan and Einstein frames is exactly the same as in the standard ADM 3+1 decomposition of GR. Finally, we point out that current numerical relativity codes can incorporate the 3+1 evolution equations of metric f(R) gravity by modifying the stress-energy tensor and adding an additional scalar field evolution equation. We hope that this work will serve as a starting point for relativists to develop fully dynamical codes for valid f(R) models.

DLLExternalCode

Energy Technology Data Exchange (ETDEWEB)

2014-05-14

DLLExternalCode is the a general dynamic-link library (DLL) interface for linking GoldSim (www.goldsim.com) with external codes. The overall concept is to use GoldSim as top level modeling software with interfaces to external codes for specific calculations. The DLLExternalCode DLL that performs the linking function is designed to take a list of code inputs from GoldSim, create an input file for the external application, run the external code, and return a list of outputs, read from files created by the external application, back to GoldSim. Instructions for creating the input file, running the external code, and reading the output are contained in an instructions file that is read and interpreted by the DLL.

High efficiency video coding coding tools and specification

CERN Document Server

Wien, Mathias

2015-01-01

The video coding standard High Efficiency Video Coding (HEVC) targets at improved compression performance for video resolutions of HD and beyond, providing Ultra HD video at similar compressed bit rates as for HD video encoded with the well-established video coding standard H.264 | AVC. Based on known concepts, new coding structures and improved coding tools have been developed and specified in HEVC. The standard is expected to be taken up easily by established industry as well as new endeavors, answering the needs of todays connected and ever-evolving online world. This book presents the High Efficiency Video Coding standard and explains it in a clear and coherent language. It provides a comprehensive and consistently written description, all of a piece. The book targets at both, newbies to video coding as well as experts in the field. While providing sections with introductory text for the beginner, it suits as a well-arranged reference book for the expert. The book provides a comprehensive reference for th...

Converter of a continuous code into the Grey code

International Nuclear Information System (INIS)

Gonchar, A.I.; TrUbnikov, V.R.

1979-01-01

Described is a converter of a continuous code into the Grey code used in a 12-charged precision amplitude-to-digital converter to decrease the digital component of spectrometer differential nonlinearity to +0.7% in the 98% range of the measured band. To construct the converter of a continuous code corresponding to the input signal amplitude into the Grey code used is the regularity in recycling of units and zeroes in each discharge of the Grey code in the case of a continuous change of the number of pulses of a continuous code. The converter is constructed on the elements of 155 series, the frequency of continuous code pulse passing at the converter input is 25 MHz

Tight bounds on computing error-correcting codes by bounded-depth circuits with arbitrary gates

Czech Academy of Sciences Publication Activity Database

Gál, A.; Hansen, A. K.; Koucký, Michal; Pudlák, Pavel; Viola, E.

2013-01-01

Roč. 59, č. 10 (2013), s. 6611-6627 ISSN 0018-9448 R&D Projects: GA AV ČR IAA100190902 Institutional support: RVO:67985840 Keywords : bounded-depth circuits * error -correcting codes * hashing Subject RIV: BA - General Mathematics Impact factor: 2.650, year: 2013 http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=6578188

Tight bounds on computing error-correcting codes by bounded-depth circuits with arbitrary gates

Czech Academy of Sciences Publication Activity Database

Gál, A.; Hansen, A. K.; Koucký, Michal; Pudlák, Pavel; Viola, E.

2013-01-01

Roč. 59, č. 10 (2013), s. 6611-6627 ISSN 0018-9448 R&D Projects: GA AV ČR IAA100190902 Institutional support: RVO:67985840 Keywords : bounded-depth circuits * error-correcting codes * hashing Subject RIV: BA - General Mathematics Impact factor: 2.650, year: 2013 http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=6578188

Minimizing embedding impact in steganography using trellis-coded quantization

Science.gov (United States)

Filler, Tomáš; Judas, Jan; Fridrich, Jessica

2010-01-01

In this paper, we propose a practical approach to minimizing embedding impact in steganography based on syndrome coding and trellis-coded quantization and contrast its performance with bounds derived from appropriate rate-distortion bounds. We assume that each cover element can be assigned a positive scalar expressing the impact of making an embedding change at that element (single-letter distortion). The problem is to embed a given payload with minimal possible average embedding impact. This task, which can be viewed as a generalization of matrix embedding or writing on wet paper, has been approached using heuristic and suboptimal tools in the past. Here, we propose a fast and very versatile solution to this problem that can theoretically achieve performance arbitrarily close to the bound. It is based on syndrome coding using linear convolutional codes with the optimal binary quantizer implemented using the Viterbi algorithm run in the dual domain. The complexity and memory requirements of the embedding algorithm are linear w.r.t. the number of cover elements. For practitioners, we include detailed algorithms for finding good codes and their implementation. Finally, we report extensive experimental results for a large set of relative payloads and for different distortion profiles, including the wet paper channel.

Qualification of the new version of HAMMER computer code

International Nuclear Information System (INIS)

Chia, C.T.

1984-06-01

(HTEC) code were tested with a great number of diferent type of experiments. This experiments covers the most important parameters in neutronic calculations, such as the cell geometry and composition. The HTEC code results have been analysed and compared with experimental data and results given by the literature and simulated by HAMMER and LEOPARD codes. The quantities used for analysis were Keff and the following integral parameters: R28 - ratio of epicadmium-to-subcadmium 238 U captures; D25 - ratio of epicadmium-to-subcadmium 235 U fission; D28 - ratio of 238 U fissions to 235 U fissions; C - ratio of 238 U captures to 235 U fissions; RC02 - ratio of epicadmium-to-subcadmium 232 Th capture. The analysis shows that the results given by the code are in good agreement with the experimental data and the results given by the other codes. The calculation that have been done with the detailed ressonance profile tabulations of plutonium isotopes shows worst results than that obtained with the ressonance parameters. Almost all the simulated cases, shows that the HTEC results are closest to the experimental data than the HAMMER results, when one do not use the detailed ressonance profile tabulations of the plutonium isotopes. (Author) [pt

Comparing Different Strategies in Directed Evolution of Enzyme Stereoselectivity: Single- versus Double-Code Saturation Mutagenesis.

Science.gov (United States)

Sun, Zhoutong; Lonsdale, Richard; Li, Guangyue; Reetz, Manfred T

2016-10-04

Saturation mutagenesis at sites lining the binding pockets of enzymes constitutes a viable protein engineering technique for enhancing or inverting stereoselectivity. Statistical analysis shows that oversampling in the screening step (the bottleneck) increases astronomically as the number of residues in the randomization site increases, which is the reason why reduced amino acid alphabets have been employed, in addition to splitting large sites into smaller ones. Limonene epoxide hydrolase (LEH) has previously served as the experimental platform in these methodological efforts, enabling comparisons between single-code saturation mutagenesis (SCSM) and triple-code saturation mutagenesis (TCSM); these employ either only one or three amino acids, respectively, as building blocks. In this study the comparative platform is extended by exploring the efficacy of double-code saturation mutagenesis (DCSM), in which the reduced amino acid alphabet consists of two members, chosen according to the principles of rational design on the basis of structural information. The hydrolytic desymmetrization of cyclohexene oxide is used as the model reaction, with formation of either (R,R)- or (S,S)-cyclohexane-1,2-diol. DCSM proves to be clearly superior to the likewise tested SCSM, affording both R,R- and S,S-selective mutants. These variants are also good catalysts in reactions of further substrates. Docking computations reveal the basis of enantioselectivity. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Aspects of the Iea-R1 research reactor seismic evaluation

International Nuclear Information System (INIS)

Mattar Neto, Miguel

1996-01-01

Codes and standards for the seismic evaluation of the research reactor IEA-R1 are presented. An approach to define the design basis earthquake based on the local seismic map and on simplified analysis methods is proposed. The site seismic evaluation indicates that the design earthquake intensity is IV MM. Therefore, according to the used codes and standards, no buildings, systems, and components seismic analysis are required. (author)

Differential DNA methylation profiles of coding and non-coding genes define hippocampal sclerosis in human temporal lobe epilepsy

Science.gov (United States)

Miller-Delaney, Suzanne F.C.; Bryan, Kenneth; Das, Sudipto; McKiernan, Ross C.; Bray, Isabella M.; Reynolds, James P.; Gwinn, Ryder; Stallings, Raymond L.

2015-01-01

Temporal lobe epilepsy is associated with large-scale, wide-ranging changes in gene expression in the hippocampus. Epigenetic changes to DNA are attractive mechanisms to explain the sustained hyperexcitability of chronic epilepsy. Here, through methylation analysis of all annotated C-phosphate-G islands and promoter regions in the human genome, we report a pilot study of the methylation profiles of temporal lobe epilepsy with or without hippocampal sclerosis. Furthermore, by comparative analysis of expression and promoter methylation, we identify methylation sensitive non-coding RNA in human temporal lobe epilepsy. A total of 146 protein-coding genes exhibited altered DNA methylation in temporal lobe epilepsy hippocampus (n = 9) when compared to control (n = 5), with 81.5% of the promoters of these genes displaying hypermethylation. Unique methylation profiles were evident in temporal lobe epilepsy with or without hippocampal sclerosis, in addition to a common methylation profile regardless of pathology grade. Gene ontology terms associated with development, neuron remodelling and neuron maturation were over-represented in the methylation profile of Watson Grade 1 samples (mild hippocampal sclerosis). In addition to genes associated with neuronal, neurotransmitter/synaptic transmission and cell death functions, differential hypermethylation of genes associated with transcriptional regulation was evident in temporal lobe epilepsy, but overall few genes previously associated with epilepsy were among the differentially methylated. Finally, a panel of 13, methylation-sensitive microRNA were identified in temporal lobe epilepsy including MIR27A, miR-193a-5p (MIR193A) and miR-876-3p (MIR876), and the differential methylation of long non-coding RNA documented for the first time. The present study therefore reports select, genome-wide DNA methylation changes in human temporal lobe epilepsy that may contribute to the molecular architecture of the epileptic brain. PMID

Computing and Displaying Isosurfaces in R

Directory of Open Access Journals (Sweden)

Dai Feng

2008-09-01

Full Text Available This paper presents R utilities for computing and displaying isosurfaces, or three-dimensional contour surfaces, from a three-dimensional array of function values. A version of the marching cubes algorithm that takes into account face and internal ambiguities is used to compute the isosurfaces. Vectorization is used to ensure adequate performance using only R code. Examples are presented showing contours of theoretical densities, density estimates, and medical imaging data. Rendering can use the rgl package or standard or grid graphics, and a set of tools for representing and rendering surfaces using standard or grid graphics is presented.

Thermal hydraulic and neutron kinetic coupled simulation of the IPR-R1 Triga reactor

Energy Technology Data Exchange (ETDEWEB)

Reis, Patricia A.L.; Costa, Antonella L.; Pereira, Claubia; Silva, Clarysson A.M. da; Veloso, Maria Auxiliadora F.; Soares, Humbero V., E-mail: patricialire@yahoo.com.br, E-mail: antonella@nuclear.ufmg.br, E-mail: claubia@nuclear.ufmg.br, E-mail: clarysson@nuclear.ufmg.br, E-mail: dora@nuclear.ufmg.br, E-mail: betovitor@ig.com.br [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Departamento de Engenharia Nuclear; Instituto Nacional de Ciencias e Tecnologia de Reatores Nucleares Inovadores (INCT/CNPq Rede), Rio de Janeiro, RJ (Brazil)

2013-07-01

The nuclear industry and the scientific community have turned the attention for the development of coupled 3D neutron kinetics (NK) and thermal-hydraulic (TH) system codes to investigate specific nuclear reactor transients. Improving in theoretical investigations of complex phenomena in nuclear reactor technology have been increased thanks to numerical methods and computational resources incorporated in nuclear codes. This paper presents a model for the IPR-R1 TRIGA research reactor using the RELAP5-3D 3.0 code. The development and the assessment of the thermal-hydraulic RELAP5 code model for the IPR-R1 have been validated for steady state and transient situations and the results were published in preceding works. Results of RELAP5-3D steady state and a transient case presented in this paper show good agreement with experimental data, validating then this model for point kinetic calculations. To supply adequate cross sections to the NK code, the WIMSD5 is being used. First results of steady state calculation using the 3D neutron modeling are being presented in this paper. (author)

Entanglement-assisted quantum MDS codes constructed from negacyclic codes

Science.gov (United States)

Chen, Jianzhang; Huang, Yuanyuan; Feng, Chunhui; Chen, Riqing

2017-12-01

Recently, entanglement-assisted quantum codes have been constructed from cyclic codes by some scholars. However, how to determine the number of shared pairs required to construct entanglement-assisted quantum codes is not an easy work. In this paper, we propose a decomposition of the defining set of negacyclic codes. Based on this method, four families of entanglement-assisted quantum codes constructed in this paper satisfy the entanglement-assisted quantum Singleton bound, where the minimum distance satisfies q+1 ≤ d≤ n+2/2. Furthermore, we construct two families of entanglement-assisted quantum codes with maximal entanglement.

The miR-10 microRNA precursor family

DEFF Research Database (Denmark)

Tehler, Disa; Høyland-Kroghsbo, Nina Molin; Lund, Anders H

2011-01-01

The miR-10 microRNA precursor family encodes a group of short non-coding RNAs involved in gene regulation. The miR-10 family is highly conserved and has sparked the interest of many research groups because of the genomic localization in the vicinity of, coexpression with and regulation of the Hox...... gene developmental regulators. Here, we review the current knowledge of the evolution, physiological function and involvement in cancer of this family of microRNAs....

TRIDENT-CTR: a two-dimensional transport code for CTR applications

International Nuclear Information System (INIS)

Seed, T.J.

1978-01-01

TRIDENT-CTR is a two-dimensional x-y and r-z geometry multigroup neutral transport code developed at Los Alamos for toroidal calculations. The use of triangular finite elements gives it the geometric flexibility to cope with the nonorthogonal shapes of many toroidal designs of current interest in the CTR community

Operational reactor physics analysis codes (ORPAC)

International Nuclear Information System (INIS)

Kumar, Jainendra; Singh, K.P.; Singh, Kanchhi

2007-07-01

For efficient, smooth and safe operation of a nuclear research reactor, many reactor physics evaluations are regularly required. As part of reactor core management the important activities are maintaining core reactivity status, core power distribution, xenon estimations, safety evaluation of in-pile irradiation samples and experimental assemblies and assessment of nuclear safety in fuel handling/storage. In-pile irradiation of samples requires a prior estimation of the reactivity load due to the sample, the heating rate and the activity developed in it during irradiation. For the safety of personnel handling irradiated samples the dose rate at the surface of shielded flask housing the irradiated sample should be less than 200 mR/Hr.Therefore, a proper shielding and radioactive cooling of the irradiated sample are required to meet the said requirement. Knowledge of xenon load variation with time (Startup-curve) helps in estimating Xenon override time. Monitoring of power in individual fuel channels during reactor operation is essential to know any abnormal power distribution to avoid unsafe situations. Complexities in the estimation of above mentioned reactor parameters and their frequent requirement compel one to use computer codes to avoid possible human errors. For efficient and quick evaluation of parameters related to reactor operations such as xenon load, critical moderator height and nuclear heating and reactivity load of isotope samples/experimental assembly, a computer code ORPAC (Operational Reactor Physics Analysis Codes) has been developed. This code is being used for regular assessment of reactor physics parameters in Dhruva and Cirus. The code ORPAC written in Visual Basic 6.0 environment incorporates several important operational reactor physics aspects on a single platform with graphical user interfaces (GUI) to make it more user-friendly and presentable. (author)

Error-correction coding

Science.gov (United States)

Hinds, Erold W. (Principal Investigator)

1996-01-01

This report describes the progress made towards the completion of a specific task on error-correcting coding. The proposed research consisted of investigating the use of modulation block codes as the inner code of a concatenated coding system in order to improve the overall space link communications performance. The study proposed to identify and analyze candidate codes that will complement the performance of the overall coding system which uses the interleaved RS (255,223) code as the outer code.

Turbo-Gallager Codes: The Emergence of an Intelligent Coding ...

African Journals Online (AJOL)

Today, both turbo codes and low-density parity-check codes are largely superior to other code families and are being used in an increasing number of modern communication systems including 3G standards, satellite and deep space communications. However, the two codes have certain distinctive characteristics that ...

TASS code topical report. V.1 TASS code technical manual

International Nuclear Information System (INIS)

Sim, Suk K.; Chang, W. P.; Kim, K. D.; Kim, H. C.; Yoon, H. Y.

1997-02-01

TASS 1.0 code has been developed at KAERI for the initial and reload non-LOCA safety analysis for the operating PWRs as well as the PWRs under construction in Korea. TASS code will replace various vendor's non-LOCA safety analysis codes currently used for the Westinghouse and ABB-CE type PWRs in Korea. This can be achieved through TASS code input modifications specific to each reactor type. The TASS code can be run interactively through the keyboard operation. A simimodular configuration used in developing the TASS code enables the user easily implement new models. TASS code has been programmed using FORTRAN77 which makes it easy to install and port for different computer environments. The TASS code can be utilized for the steady state simulation as well as the non-LOCA transient simulations such as power excursions, reactor coolant pump trips, load rejections, loss of feedwater, steam line breaks, steam generator tube ruptures, rod withdrawal and drop, and anticipated transients without scram (ATWS). The malfunctions of the control systems, components, operator actions and the transients caused by the malfunctions can be easily simulated using the TASS code. This technical report describes the TASS 1.0 code models including reactor thermal hydraulic, reactor core and control models. This TASS code models including reactor thermal hydraulic, reactor core and control models. This TASS code technical manual has been prepared as a part of the TASS code manual which includes TASS code user's manual and TASS code validation report, and will be submitted to the regulatory body as a TASS code topical report for a licensing non-LOCA safety analysis for the Westinghouse and ABB-CE type PWRs operating and under construction in Korea. (author). 42 refs., 29 tabs., 32 figs

Development and Validation of A Nuclear Fuel Cycle Analysis Tool: A FUTURE Code

Energy Technology Data Exchange (ETDEWEB)

Kim, S. K.; Ko, W. I. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Lee, Yoon Hee [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)

2013-10-15

This paper presents the development and validation methods of the FUTURE (FUel cycle analysis Tool for nUcleaR Energy) code, which was developed for a dynamic material flow evaluation and economic analysis of the nuclear fuel cycle. This code enables an evaluation of a nuclear material flow and its economy for diverse nuclear fuel cycles based on a predictable scenario. The most notable virtue of this FUTURE code, which was developed using C and MICROSOFT SQL DBMS, is that a program user can design a nuclear fuel cycle process easily using a standard process on the canvas screen through a drag-and-drop method. From the user's point of view, this code is very easy to use thanks to its high flexibility. In addition, the new code also enables the maintenance of data integrity by constructing a database environment of the results of the nuclear fuel cycle analyses.

Decoding of concatenated codes with interleaved outer codes

DEFF Research Database (Denmark)

Justesen, Jørn; Høholdt, Tom; Thommesen, Christian

2004-01-01

Recently Bleichenbacher et al. proposed a decoding algorithm for interleaved (N, K) Reed-Solomon codes, which allows close to N-K errors to be corrected in many cases. We discuss the application of this decoding algorithm to concatenated codes.......Recently Bleichenbacher et al. proposed a decoding algorithm for interleaved (N, K) Reed-Solomon codes, which allows close to N-K errors to be corrected in many cases. We discuss the application of this decoding algorithm to concatenated codes....

Fast Coding Unit Encoding Mechanism for Low Complexity Video Coding

OpenAIRE

Gao, Yuan; Liu, Pengyu; Wu, Yueying; Jia, Kebin; Gao, Guandong

2016-01-01

In high efficiency video coding (HEVC), coding tree contributes to excellent compression performance. However, coding tree brings extremely high computational complexity. Innovative works for improving coding tree to further reduce encoding time are stated in this paper. A novel low complexity coding tree mechanism is proposed for HEVC fast coding unit (CU) encoding. Firstly, this paper makes an in-depth study of the relationship among CU distribution, quantization parameter (QP) and content ...

Input modelling of ASSERT-PV V2R8M1 for RUFIC fuel bundle

Energy Technology Data Exchange (ETDEWEB)

Park, Joo Hwan; Suk, Ho Chun

2001-02-01

This report describes the input modelling for subchannel analysis of CANFLEX-RU (RUFIC) fuel bundle which has been developed for an advanced fuel bundle of CANDU-6 reactor, using ASSERT-PV V2R8M1 code. Execution file of ASSERT-PV V2R8M1 code was recently transferred from AECL under JRDC agreement between KAERI and AECL. SSERT-PV V2R8M1 which is quite different from COBRA-IV-i code has been developed for thermalhydraulic analysis of CANDU-6 fuel channel by subchannel analysis method and updated so that 43-element CANDU fuel geometry can be applied. Hence, ASSERT code can be applied to the subchannel analysis of RUFIC fuel bundle. The present report was prepared for ASSERT input modelling of RUFIC fuel bundle. Since the ASSERT results highly depend on user's input modelling, the calculation results may be quite different among the user's input models. The objective of the present report is the preparation of detail description of the background information for input data and gives credibility of the calculation results.

An Eulerian transport-dispersion model of passive effluents: the Difeul code

International Nuclear Information System (INIS)

Wendum, D.

1994-11-01

R and D has decided to develop an Eulerian diffusion model easy to adapt to meteorological data coming from different sources: for instance the ARPEGE code of Meteo-France or the MERCURE code of EDF. We demand this in order to be able to apply the code in independent cases: a posteriori studies of accidental releases from nuclear power plants ar large or medium scale, simulation of urban pollution episodes within the ''Reactive Atmospheric Flows'' research project. For simplicity reasons, the numerical formulation of our code is the same as the one used in Meteo-France's MEDIA model. The numerical tests presented in this report show the good performance of those schemes. In order to illustrate the method by a concrete example a fictitious release from Saint-Laurent has been simulated at national scale: the results of this simulation agree quite well with those of the trajectory model DIFTRA. (author). 6 figs., 4 tabs

Codes Over Hyperfields

Directory of Open Access Journals (Sweden)

Atamewoue Surdive

2017-12-01

Full Text Available In this paper, we define linear codes and cyclic codes over a finite Krasner hyperfield and we characterize these codes by their generator matrices and parity check matrices. We also demonstrate that codes over finite Krasner hyperfields are more interesting for code theory than codes over classical finite fields.

Amino acid codes in mitochondria as possible clues to primitive codes

Science.gov (United States)

Jukes, T. H.

1981-01-01

Differences between mitochondrial codes and the universal code indicate that an evolutionary simplification has taken place, rather than a return to a more primitive code. However, these differences make it evident that the universal code is not the only code possible, and therefore earlier codes may have differed markedly from the previous code. The present universal code is probably a 'frozen accident.' The change in CUN codons from leucine to threonine (Neurospora vs. yeast mitochondria) indicates that neutral or near-neutral changes occurred in the corresponding proteins when this code change took place, caused presumably by a mutation in a tRNA gene.

Unfolding code for neutron spectrometry based on neural nets technology

Energy Technology Data Exchange (ETDEWEB)

Ortiz R, J. M.; Vega C, H. R., E-mail: morvymm@yahoo.com.mx [Universidad Autonoma de Zacatecas, Unidad Academica de Ingenieria Electrica, Apdo. Postal 336, 98000 Zacatecas (Mexico)

2012-10-15

The most delicate part of neutron spectrometry, is the unfolding process. The derivation of the spectral information is not simple because the unknown is not given directly as a result of the measurements. The drawbacks associated with traditional unfolding procedures have motivated the need of complementary approaches. Novel methods based on Artificial Neural Networks have been widely investigated. In this work, a neutron spectrum unfolding code based on neural nets technology is presented. This unfolding code called Neutron Spectrometry and Dosimetry by means of Artificial Neural Networks was designed in a graphical interface under LabVIEW programming environment. The core of the code is an embedded neural network architecture, previously optimized by the {sup R}obust Design of Artificial Neural Networks Methodology{sup .} The main features of the code are: is easy to use, friendly and intuitive to the user. This code was designed for a Bonner Sphere System based on a {sup 6}Lil(Eu) neutron detector and a response matrix expressed in 60 energy bins taken from an International Atomic Energy Agency compilation. The main feature of the code is that as entrance data, only seven rate counts measurement with a Bonner spheres spectrometer are required for simultaneously unfold the 60 energy bins of the neutron spectrum and to calculate 15 dosimetric quantities, for radiation protection porpoises. This code generates a full report in html format with all relevant information. (Author)

Thermal hydraulic analysis of the IPR-R1 TRIGA reactor; Analise termo-hidraulica do reator TRIGA IPR-R1

Energy Technology Data Exchange (ETDEWEB)

Veloso, Marcelo Antonio [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN), Belo Horizonte, MG (Brazil); Fortini, Maria Auxiliadora [Minas Gerais Univ., Belo Horizonte, MG (Brazil). Dept. de Engenharia Nuclear

2002-07-01

The subchannel approach, normally employed for the analysis of power reactor cores that work under forced convection, have been used for the thermal hydraulic evaluation of a TRIGA Mark I reactor, named IPR-R1, at 250 kW power level. This was accomplished by using the PANTERA-1P subchannel code, which has been conveniently adapted to the characteristics of natural convection of TRIGA reactors. The analysis of results indicates that the steady state operation of IPR-R1 at 250 kW do not imply risks to installations, workers and public. (author)

Performance of the coupled thermalhydraulics/neutron kinetics code R/P/C on workstation clusters and multiprocessor systems

International Nuclear Information System (INIS)

Hammer, C.; Paffrath, M.; Boeer, R.; Finnemann, H.; Jackson, C.J.

1996-01-01

The light water reactor core simulation code PANBOX has been coupled with the transient analysis code RELAP5 for the purpose of performing plant safety analyses with a three-dimensional (3-D) neutron kinetics model. The system has been parallelized to improve the computational efficiency. The paper describes the features of this system with emphasis on performance aspects. Performance results are given for different types of parallelization, i. e. for using an automatic parallelizing compiler, using the portable PVM platform on a workstation cluster, using PVM on a shared memory multiprocessor, and for using machine dependent interfaces. (author)

Analysis of quantum error-correcting codes: Symplectic lattice codes and toric codes

Science.gov (United States)

Harrington, James William

Quantum information theory is concerned with identifying how quantum mechanical resources (such as entangled quantum states) can be utilized for a number of information processing tasks, including data storage, computation, communication, and cryptography. Efficient quantum algorithms and protocols have been developed for performing some tasks (e.g. , factoring large numbers, securely communicating over a public channel, and simulating quantum mechanical systems) that appear to be very difficult with just classical resources. In addition to identifying the separation between classical and quantum computational power, much of the theoretical focus in this field over the last decade has been concerned with finding novel ways of encoding quantum information that are robust against errors, which is an important step toward building practical quantum information processing devices. In this thesis I present some results on the quantum error-correcting properties of oscillator codes (also described as symplectic lattice codes) and toric codes. Any harmonic oscillator system (such as a mode of light) can be encoded with quantum information via symplectic lattice codes that are robust against shifts in the system's continuous quantum variables. I show the existence of lattice codes whose achievable rates match the one-shot coherent information over the Gaussian quantum channel. Also, I construct a family of symplectic self-dual lattices and search for optimal encodings of quantum information distributed between several oscillators. Toric codes provide encodings of quantum information into two-dimensional spin lattices that are robust against local clusters of errors and which require only local quantum operations for error correction. Numerical simulations of this system under various error models provide a calculation of the accuracy threshold for quantum memory using toric codes, which can be related to phase transitions in certain condensed matter models. I also present

Theoretical treatment of molecular photoionization based on the R-matrix method

International Nuclear Information System (INIS)

Tashiro, Motomichi

2012-01-01

The R-matrix method was implemented to treat molecular photoionization problem based on the UK R-matrix codes. This method was formulated to treat photoionization process long before, however, its application has been mostly limited to photoionization of atoms. Application of the method to valence photoionization as well as inner-shell photoionization process will be presented.

Global error estimation based on the tolerance proportionality for some adaptive Runge-Kutta codes

Science.gov (United States)

Calvo, M.; González-Pinto, S.; Montijano, J. I.

2008-09-01

Modern codes for the numerical solution of Initial Value Problems (IVPs) in ODEs are based in adaptive methods that, for a user supplied tolerance [delta], attempt to advance the integration selecting the size of each step so that some measure of the local error is [similar, equals][delta]. Although this policy does not ensure that the global errors are under the prescribed tolerance, after the early studies of Stetter [Considerations concerning a theory for ODE-solvers, in: R. Burlisch, R.D. Grigorieff, J. Schröder (Eds.), Numerical Treatment of Differential Equations, Proceedings of Oberwolfach, 1976, Lecture Notes in Mathematics, vol. 631, Springer, Berlin, 1978, pp. 188-200; Tolerance proportionality in ODE codes, in: R. März (Ed.), Proceedings of the Second Conference on Numerical Treatment of Ordinary Differential Equations, Humbold University, Berlin, 1980, pp. 109-123] and the extensions of Higham [Global error versus tolerance for explicit Runge-Kutta methods, IMA J. Numer. Anal. 11 (1991) 457-480; The tolerance proportionality of adaptive ODE solvers, J. Comput. Appl. Math. 45 (1993) 227-236; The reliability of standard local error control algorithms for initial value ordinary differential equations, in: Proceedings: The Quality of Numerical Software: Assessment and Enhancement, IFIP Series, Springer, Berlin, 1997], it has been proved that in many existing explicit Runge-Kutta codes the global errors behave asymptotically as some rational power of [delta]. This step-size policy, for a given IVP, determines at each grid point tn a new step-size hn+1=h(tn;[delta]) so that h(t;[delta]) is a continuous function of t. In this paper a study of the tolerance proportionality property under a discontinuous step-size policy that does not allow to change the size of the step if the step-size ratio between two consecutive steps is close to unity is carried out. This theory is applied to obtain global error estimations in a few problems that have been solved with

Annotation and analysis of a large cuticular protein family with the R&R Consensus in Anopheles gambiae

Directory of Open Access Journals (Sweden)

He Ningjia

2008-01-01

Full Text Available Abstract Background The most abundant family of insect cuticular proteins, the CPR family, is recognized by the R&R Consensus, a domain of about 64 amino acids that binds to chitin and is present throughout arthropods. Several species have now been shown to have more than 100 CPR genes, inviting speculation as to the functional importance of this large number and diversity. Results We have identified 156 genes in Anopheles gambiae that code for putative cuticular proteins in this CPR family, over 1% of the total number of predicted genes in this species. Annotation was verified using several criteria including identification of TATA boxes, INRs, and DPEs plus support from proteomic and gene expression analyses. Two previously recognized CPR classes, RR-1 and RR-2, form separate, well-supported clades with the exception of a small set of genes with long branches whose relationships are poorly resolved. Several of these outliers have clear orthologs in other species. Although both clades are under purifying selection, the RR-1 variant of the R&R Consensus is evolving at twice the rate of the RR-2 variant and is structurally more labile. In contrast, the regions flanking the R&R Consensus have diversified in amino-acid composition to a much greater extent in RR-2 genes compared with RR-1 genes. Many genes are found in compact tandem arrays that may include similar or dissimilar genes but always include just one of the two classes. Tandem arrays of RR-2 genes frequently contain subsets of genes coding for highly similar proteins (sequence clusters. Properties of the proteins indicated that each cluster may serve a distinct function in the cuticle. Conclusion The complete annotation of this large gene family provides insight on the mechanisms of gene family evolution and clues about the need for so many CPR genes. These data also should assist annotation of other Anopheles genes.

Coding for dummies

CERN Document Server

Abraham, Nikhil

2015-01-01

Hands-on exercises help you learn to code like a pro No coding experience is required for Coding For Dummies,your one-stop guide to building a foundation of knowledge inwriting computer code for web, application, and softwaredevelopment. It doesn't matter if you've dabbled in coding or neverwritten a line of code, this book guides you through the basics.Using foundational web development languages like HTML, CSS, andJavaScript, it explains in plain English how coding works and whyit's needed. Online exercises developed by Codecademy, a leading online codetraining site, help hone coding skill

Moral sensitivity relating to the application of the code of ethics.

Science.gov (United States)

Kim, Yong-Soon; Kang, Se-Won; Ahn, Jeong-Ah

2013-06-01

This study investigated the clinical application of the 2006 Third Revised Korean Nurses' Code of Ethics and the moral sensitivity of nurses. A total of 303 clinical nurses in South Korea participated in the survey in May and June 2011. As instruments of this study, we used the 15 statements of the Korean Nurses' Code of Ethics and Korean Moral Sensitivity Questionnaire. The mean score for application was 3.77 ± 0.59 (out of 5), and the mean score for moral sensitivity was 5.14 ± 0.55 (out of 7). The correlation coefficient (r) of the application and moral sensitivity was 0.336 (p moral sensitivity also scored high on application (t = -5.018, p moral sensitivity of nurses are necessary for improving the application of the code of ethics.

Application of the TWODANT code system to pressure vessel dosimetry calculations

International Nuclear Information System (INIS)

Parsons, D.K.; Alcouffe, R.E.; Marr, D.R.; Urban, W.T.

1993-01-01

The TWODANT code system has recently been enhanced to include TWODANT/GQ and THREEDANT. TWODANT/GQ solves the two-dimensional form of the discrete ordinates approximation to the transport equation on a generalized quadrilateral mesh. This geometric capability is very general and allows nearly exact representations of X-Y or R-Z geometries. THREEDANT solves the three-dimensional form of the discrete ordinates equations. In addition to the conventional coarse-mesh material zone input, THREEDANT can also be linked to a three-dimensional nested-region mesh generation code called FRAC-IN-THE-BOX. THREEDANT can thus model a much wider variety of geometric shapes than any other discrete ordinates code. These enhanced geometric modeling capabilities are applied here to the analysis of the VENUS PWR Mock-Up Facility

Detecting non-coding selective pressure in coding regions

Directory of Open Access Journals (Sweden)

Blanchette Mathieu

2007-02-01

Full Text Available Abstract Background Comparative genomics approaches, where orthologous DNA regions are compared and inter-species conserved regions are identified, have proven extremely powerful for identifying non-coding regulatory regions located in intergenic or intronic regions. However, non-coding functional elements can also be located within coding region, as is common for exonic splicing enhancers, some transcription factor binding sites, and RNA secondary structure elements affecting mRNA stability, localization, or translation. Since these functional elements are located in regions that are themselves highly conserved because they are coding for a protein, they generally escaped detection by comparative genomics approaches. Results We introduce a comparative genomics approach for detecting non-coding functional elements located within coding regions. Codon evolution is modeled as a mixture of codon substitution models, where each component of the mixture describes the evolution of codons under a specific type of coding selective pressure. We show how to compute the posterior distribution of the entropy and parsimony scores under this null model of codon evolution. The method is applied to a set of growth hormone 1 orthologous mRNA sequences and a known exonic splicing elements is detected. The analysis of a set of CORTBP2 orthologous genes reveals a region of several hundred base pairs under strong non-coding selective pressure whose function remains unknown. Conclusion Non-coding functional elements, in particular those involved in post-transcriptional regulation, are likely to be much more prevalent than is currently known. With the numerous genome sequencing projects underway, comparative genomics approaches like that proposed here are likely to become increasingly powerful at detecting such elements.

Dynamic Shannon Coding

OpenAIRE

Gagie, Travis

2005-01-01

We present a new algorithm for dynamic prefix-free coding, based on Shannon coding. We give a simple analysis and prove a better upper bound on the length of the encoding produced than the corresponding bound for dynamic Huffman coding. We show how our algorithm can be modified for efficient length-restricted coding, alphabetic coding and coding with unequal letter costs.

The correspondence between projective codes and 2-weight codes

NARCIS (Netherlands)

Brouwer, A.E.; Eupen, van M.J.M.; Tilborg, van H.C.A.; Willems, F.M.J.

1994-01-01

The hyperplanes intersecting a 2-weight code in the same number of points obviously form the point set of a projective code. On the other hand, if we have a projective code C, then we can make a 2-weight code by taking the multiset of points E PC with multiplicity "Y(w), where W is the weight of

Upgrade of The Cyber R and D Platform

Energy Technology Data Exchange (ETDEWEB)

Ko, Chang Seong; Lee, Kyung Jong; Yang, Tae Chun; Kim, Tae Sung; Hong, Hyun Joo [Kyungsung Univ., Seoul (Korea, Republic of)

2007-02-15

Recently, it is necessary to demonstrate the program and experience the safety of radiation disposal by themselves. The objective of this research is to develop a cyber-based performance assessment program for the radiation disposal which is fit for Korean environment. This research covers the following four areas: - Development of Java-based MDPSA pre-processor - Linking MDPSA code to pre and post-processor. - Linking MDPSA code to Cyber R and D platform - Modification of the Cyber R and D platform. The results of this research can be used as a PR database for the central and local government. Using the web-based system, any person or interest group can plug in the system and experience the safety and clarity of the atomic energy and radiation disposal. Also, within the KAERI, research-related knowledge can be stored as a structured format. This enables the sharing, reusability, transparency, reliability and transferability of research results, and promotes the efficiency of research efforts within and outside of research team.

Upgrade of The Cyber R and D Platform

International Nuclear Information System (INIS)

Ko, Chang Seong; Lee, Kyung Jong; Yang, Tae Chun; Kim, Tae Sung; Hong, Hyun Joo

2007-02-01

Recently, it is necessary to demonstrate the program and experience the safety of radiation disposal by themselves. The objective of this research is to develop a cyber-based performance assessment program for the radiation disposal which is fit for Korean environment. This research covers the following four areas: - Development of Java-based MDPSA pre-processor - Linking MDPSA code to pre and post-processor. - Linking MDPSA code to Cyber R and D platform - Modification of the Cyber R and D platform. The results of this research can be used as a PR database for the central and local government. Using the web-based system, any person or interest group can plug in the system and experience the safety and clarity of the atomic energy and radiation disposal. Also, within the KAERI, research-related knowledge can be stored as a structured format. This enables the sharing, reusability, transparency, reliability and transferability of research results, and promotes the efficiency of research efforts within and outside of research team

Quality Improvement of MARS Code and Establishment of Code Coupling

International Nuclear Information System (INIS)

Chung, Bub Dong; Jeong, Jae Jun; Kim, Kyung Doo

2010-04-01

The improvement of MARS code quality and coupling with regulatory auditing code have been accomplished for the establishment of self-reliable technology based regulatory auditing system. The unified auditing system code was realized also by implementing the CANDU specific models and correlations. As a part of the quality assurance activities, the various QA reports were published through the code assessments. The code manuals were updated and published a new manual which describe the new models and correlations. The code coupling methods were verified though the exercise of plant application. The education-training seminar and technology transfer were performed for the code users. The developed MARS-KS is utilized as reliable auditing tool for the resolving the safety issue and other regulatory calculations. The code can be utilized as a base technology for GEN IV reactor applications

Development Perspective of Regulatory Audit Code System for SFR Nuclear Safety Evaluation

Energy Technology Data Exchange (ETDEWEB)

Bae, Moo Hoon; Lee, Gil Soo; Shin, An Dong; Suh, Nam Duk [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

2012-05-15

A sodium-cooled fast reactor (SFR) in Korea is based on the KALIMER-600 concept developed by KAERI. Based on 'Long-term R and D Plan for Future Reactor Systems' which was approved by the Korea Atomic Energy Commission in 2008, the KAERI designer is scheduled to apply the design certification of the prototype SFR in 2017. In order to establish regulatory infrastructure for the licensing of a prototype SFR, KINS has develop the regulatory requirements for the demonstration SFR since 2010, and are scheduled to develop the regulatory audit code systems in regard to core, fuel, and system, etc. since 2012. In this study, the domestic code systems used for core design and safety evaluation of PWRs and the nuclear physics and code system for SFRs were briefly reviewed, and the development perspective of regulatory audit code system for SFR nuclear safety evaluation were derived

Simulation of Weld Mechanical Behavior to Include Welding-Induced Residual Stress and Distortion: Coupling of SYSWELD and Abaqus Codes

Science.gov (United States)

2015-11-01

Memorandum Simulation of Weld Mechanical Behavior to Include Welding-Induced Residual Stress and Distortion: Coupling of SYSWELD and Abaqus Codes...Weld Mechanical Behavior to Include Welding-Induced Residual Stress and Distortion: Coupling of SYSWELD and Abaqus Codes by Charles R. Fisher...Welding- Induced Residual Stress and Distortion: Coupling of SYSWELD and Abaqus Codes 5a. CONTRACT NUMBER N/A 5b. GRANT NUMBER N/A 5c

ARCADIAR - A New Generation of Coupled Neutronics / Core Thermal- Hydraulics Code System at AREVA NP

International Nuclear Information System (INIS)

Curca-Tivig, Florin; Merk, Stephan; Pautz, Andreas; Thareau, Sebastien

2007-01-01

Anticipating future needs of our customers and willing to concentrate synergies and competences existing in the company for the benefit of our customers, AREVA NP decided in 2002 to develop the next generation of coupled neutronics/ core thermal-hydraulic (TH) code systems for fuel assembly and core design calculations for both, PWR and BWR applications. The global CONVERGENCE project was born: after a feasibility study of one year (2002) and a conceptual phase of another year (2003), development was started at the beginning of 2004. The present paper introduces the CONVERGENCE project, presents the main feature of the new code system ARCADIA R and concludes on customer benefits. ARCADIA R is designed to meet AREVA NP market and customers' requirements worldwide. Besides state-of-the-art physical modeling, numerical performance and industrial functionality, the ARCADIA R system is featuring state-of-the-art software engineering. The new code system will bring a series of benefits for our customers: e.g. improved accuracy for heterogeneous cores (MOX/ UOX, Gd...), better description of nuclide chains, and access to local neutronics/ thermal-hydraulics and possibly thermal-mechanical information (3D pin by pin full core modeling). ARCADIA is a registered trademark of AREVA NP. (authors)

Feasibility study of the vectorization of nuclear codes used at the ENEL Thermal and Nuclear Research Centre

International Nuclear Information System (INIS)

Di Pasquantonio, F.

1987-01-01

The purpose of this report is that of analyzing tha problems connected with the vectorization and/or multitasking of several computer codes utilized in the ENEL-DSR Centro Ricerca Termica e Nucleare. After some general remarks on vector computers the analysis is focused on some topic relating to vectorization and multitasking of programs written for scalar computers. The priority for vectorization and/or multitasking has been given at the following codes: 1) DOT 4.2 (radiation transport and shielding); 2) QUANDRY (accidental and operating transients in LWR cores); 3) MORSE and MCNP (Monte Carlo codes for radiation transport and shielding); 4) RELAP (accidental and operating transients in LWR plants); 5) TRAP-MELT and NAUA (evaluation of source term). The principal results of the study are the following: 1) For the DOT 4.2 code it is convenients to improve the vectorized version DOT IV/C developed by Swanson introducing the parallel S.O.R. iterative method; 2) For the code QUANDRY it is proposed to introduce the three dimensional red-black mesh point ordering named ''diagonal method''; 3) To implements, on the CRAY X/MP 48, the multitasked version of the code MCNP developed by the Los Alamos National Lboratory; 4) To implements, on the CRAY X/MP 12, the vectorized and optimized version of the codes RELAP5/MOD1-MOD2 developed by J.R.C. EUROATOM-Ispra; 5) For the codes TRAP-MELT and NAUA the insertion of the vectorized routines LSODP na LSODPK for dominanting stiff cases

DEVELOPMENT AND VALIDATION OF A NUCLEAR FUEL CYCLE ANALYSIS TOOL: A FUTURE CODE

Directory of Open Access Journals (Sweden)

S.K. KIM

2013-10-01

Full Text Available This paper presents the development and validation methods of the FUTURE (FUel cycle analysis Tool for nUcleaR Energy code, which was developed for a dynamic material flow evaluation and economic analysis of the nuclear fuel cycle. This code enables an evaluation of a nuclear material flow and its economy for diverse nuclear fuel cycles based on a predictable scenario. The most notable virtue of this FUTURE code, which was developed using C# and MICROSOFT SQL DBMS, is that a program user can design a nuclear fuel cycle process easily using a standard process on the canvas screen through a drag-and-drop method. From the user's point of view, this code is very easy to use thanks to its high flexibility. In addition, the new code also enables the maintenance of data integrity by constructing a database environment of the results of the nuclear fuel cycle analyses.

Development of probabilistic fracture mechanics code PASCAL and user's manual

Energy Technology Data Exchange (ETDEWEB)

Shibata, Katsuyuki; Onizawa, Kunio [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Li, Yinsheng; Kato, Daisuke [Fuji Research Institute Corporation, Tokyo (Japan)

2001-03-01

As a part of the aging and structural integrity research for LWR components, a new PFM (Probabilistic Fracture Mechanics) code PASCAL (PFM Analysis of Structural Components in Aging LWR) has been developed since FY1996. This code evaluates the failure probability of an aged reactor pressure vessel subjected to transient loading such as PTS (Pressurized Thermal Shock). The development of the code has been aimed to improve the accuracy and reliability of analysis by introducing new analysis methodologies and algorithms considering the recent development in the fracture mechanics methodologies and computer performance. The code has some new functions in optimized sampling and cell dividing procedure in stratified Monte Carlo simulation, elastic-plastic fracture criterion of R6 method, extension analysis models in semi-elliptical crack, evaluation of effect of thermal annealing and etc. In addition, an input data generator of temperature and stress distribution time histories was also prepared in the code. Functions and performance of the code have been confirmed based on the verification analyses and some case studies on the influence parameters. The present phase of the development will be completed in FY2000. Thus this report provides the user's manual and theoretical background of the code. (author)

Multiple component codes based generalized LDPC codes for high-speed optical transport.

Science.gov (United States)

Djordjevic, Ivan B; Wang, Ting

2014-07-14

A class of generalized low-density parity-check (GLDPC) codes suitable for optical communications is proposed, which consists of multiple local codes. It is shown that Hamming, BCH, and Reed-Muller codes can be used as local codes, and that the maximum a posteriori probability (MAP) decoding of these local codes by Ashikhmin-Lytsin algorithm is feasible in terms of complexity and performance. We demonstrate that record coding gains can be obtained from properly designed GLDPC codes, derived from multiple component codes. We then show that several recently proposed classes of LDPC codes such as convolutional and spatially-coupled codes can be described using the concept of GLDPC coding, which indicates that the GLDPC coding can be used as a unified platform for advanced FEC enabling ultra-high speed optical transport. The proposed class of GLDPC codes is also suitable for code-rate adaption, to adjust the error correction strength depending on the optical channel conditions.

Contribution of 194.1 keV Resonance to 17O(p, alpha) 14N Reaction Rate using R Matrix Code

International Nuclear Information System (INIS)

Chafa, A.; Messili, F.Z.; Barhoumi, S.

2009-01-01

Knowledge of the 17 O(p, alpha ) 14 N reaction rates is required for evaluating elemental abundances in a number of hydrogen - burning stellar sites. This reaction is specifically very important for nucleosynthesis of the rare oxygen isotope 17 O. Classical novae are thought to be a major source of 17 O in the Galaxy and produce the short-live radioisotope 18 F whose + decay is followed by a gamma ray emission which could be observed with satellites such as the Integral observatory. As the 17 O(p, alpha) 14 N and 17 O(p, alpha ) 18 F reactions govern the destruction of 17 O and the formation of 1 '8F, their rates are decisive in determining the final abundances of these isotopes. Stellar temperatures of primary importance for nucleosynthesis are typically in the ranges T = 0.01-0.1 GK for red giant, AGB, and massive stars, and T 0.01-0.4 GK for classical nova explosions In recent work, we observed, for the first time, a resonance a 183.3 keV corresponding to level in 18 F at Ex 5789.8 ± 0.3 keV. A new astrophysical parameters of this resonance are found. In this work we study this reaction using numerical code based on R matrix method including the new values of level energy and parameters of 183.3 keV resonance in order to show his contribution to 17 O(p, alpha) 14 N reaction rates. We also use old parameters values of this resonance given in Keiser work for comparison. We show that this resonance predominate the reaction rates in all range of stellar temperature for classical nova explosions. This is in good agreement with our work with experimental method. We also study cross section and differential cross section 17 O(p, alpha ) 14 N reaction with R matrix method

Vector Network Coding

OpenAIRE

Ebrahimi, Javad; Fragouli, Christina

2010-01-01

We develop new algebraic algorithms for scalar and vector network coding. In vector network coding, the source multicasts information by transmitting vectors of length L, while intermediate nodes process and combine their incoming packets by multiplying them with L X L coding matrices that play a similar role as coding coefficients in scalar coding. Our algorithms for scalar network jointly optimize the employed field size while selecting the coding coefficients. Similarly, for vector co...

Rateless feedback codes

DEFF Research Database (Denmark)

Sørensen, Jesper Hemming; Koike-Akino, Toshiaki; Orlik, Philip

2012-01-01

This paper proposes a concept called rateless feedback coding. We redesign the existing LT and Raptor codes, by introducing new degree distributions for the case when a few feedback opportunities are available. We show that incorporating feedback to LT codes can significantly decrease both...... the coding overhead and the encoding/decoding complexity. Moreover, we show that, at the price of a slight increase in the coding overhead, linear complexity is achieved with Raptor feedback coding....

Progress of IRSN R&D on ITER Safety Assessment

Science.gov (United States)

Van Dorsselaere, J. P.; Perrault, D.; Barrachin, M.; Bentaib, A.; Gensdarmes, F.; Haeck, W.; Pouvreau, S.; Salat, E.; Seropian, C.; Vendel, J.

2012-08-01

The French "Institut de Radioprotection et de Sûreté Nucléaire" (IRSN), in support to the French "Autorité de Sûreté Nucléaire", is analysing the safety of ITER fusion installation on the basis of the ITER operator's safety file. IRSN set up a multi-year R&D program in 2007 to support this safety assessment process. Priority has been given to four technical issues and the main outcomes of the work done in 2010 and 2011 are summarized in this paper: for simulation of accident scenarios in the vacuum vessel, adaptation of the ASTEC system code; for risk of explosion of gas-dust mixtures in the vacuum vessel, adaptation of the TONUS-CFD code for gas distribution, development of DUST code for dust transport, and preparation of IRSN experiments on gas inerting, dust mobilization, and hydrogen-dust mixtures explosion; for evaluation of the efficiency of the detritiation systems, thermo-chemical calculations of tritium speciation during transport in the gas phase and preparation of future experiments to evaluate the most influent factors on detritiation; for material neutron activation, adaptation of the VESTA Monte Carlo depletion code. The first results of these tasks have been used in 2011 for the analysis of the ITER safety file. In the near future, this R&D global programme may be reoriented to account for the feedback of the latter analysis or for new knowledge.

Dynamische Programm-Code-Verwaltung und -Optimierung für eingebettete Systeme

OpenAIRE

Schell, Dominic

2009-01-01

Bei Desktop-PCs ist ein großer Hauptspeicherausbau im Bereich jenseits von 1 GB dank gesunkener Speicherpreise und auf Grund gestiegener Anforderungen keine Seltenheit mehr. Es existiert jedoch eine Unmenge Kleinstrechner, wie z.B. im Automobilbereich eingesetzte Steuergeräte, die sich einen großen Speicherausbau wegen des Platzbedarfs der Speicherchips, deren Energiekonsum und den zusätzlichen Kosten nicht leisten können. Ein wichtiges Ziel beim Erzeugen der Software für eingebettete Systeme...

New quantum codes derived from a family of antiprimitive BCH codes

Science.gov (United States)

Liu, Yang; Li, Ruihu; Lü, Liangdong; Guo, Luobin

The Bose-Chaudhuri-Hocquenghem (BCH) codes have been studied for more than 57 years and have found wide application in classical communication system and quantum information theory. In this paper, we study the construction of quantum codes from a family of q2-ary BCH codes with length n=q2m+1 (also called antiprimitive BCH codes in the literature), where q≥4 is a power of 2 and m≥2. By a detailed analysis of some useful properties about q2-ary cyclotomic cosets modulo n, Hermitian dual-containing conditions for a family of non-narrow-sense antiprimitive BCH codes are presented, which are similar to those of q2-ary primitive BCH codes. Consequently, via Hermitian Construction, a family of new quantum codes can be derived from these dual-containing BCH codes. Some of these new antiprimitive quantum BCH codes are comparable with those derived from primitive BCH codes.

Surface acoustic wave coding for orthogonal frequency coded devices

Science.gov (United States)

Malocha, Donald (Inventor); Kozlovski, Nikolai (Inventor)

2011-01-01

Methods and systems for coding SAW OFC devices to mitigate code collisions in a wireless multi-tag system. Each device producing plural stepped frequencies as an OFC signal with a chip offset delay to increase code diversity. A method for assigning a different OCF to each device includes using a matrix based on the number of OFCs needed and the number chips per code, populating each matrix cell with OFC chip, and assigning the codes from the matrix to the devices. The asynchronous passive multi-tag system includes plural surface acoustic wave devices each producing a different OFC signal having the same number of chips and including a chip offset time delay, an algorithm for assigning OFCs to each device, and a transceiver to transmit an interrogation signal and receive OFC signals in response with minimal code collisions during transmission.

Separate Turbo Code and Single Turbo Code Adaptive OFDM Transmissions

Directory of Open Access Journals (Sweden)

Burr Alister

2009-01-01

Full Text Available Abstract This paper discusses the application of adaptive modulation and adaptive rate turbo coding to orthogonal frequency-division multiplexing (OFDM, to increase throughput on the time and frequency selective channel. The adaptive turbo code scheme is based on a subband adaptive method, and compares two adaptive systems: a conventional approach where a separate turbo code is used for each subband, and a single turbo code adaptive system which uses a single turbo code over all subbands. Five modulation schemes (BPSK, QPSK, 8AMPM, 16QAM, and 64QAM are employed and turbo code rates considered are and . The performances of both systems with high ( and low ( BER targets are compared. Simulation results for throughput and BER show that the single turbo code adaptive system provides a significant improvement.

rTMS: A Treatment to Restore Function After Severe TBI

Science.gov (United States)

2015-10-01

R&D Program, Psychological Health/Traumatic Brain Injury Research Program, Congressionally Directed Medical Research Programs, Clinical and...resistant epilepsy . Specific Aims: Aim 1: Characterizing the time-frequency dynamics of odor coding and categorization. Aim 2: Characterizing the

Codes and curves

CERN Document Server

Walker, Judy L

2000-01-01

When information is transmitted, errors are likely to occur. Coding theory examines efficient ways of packaging data so that these errors can be detected, or even corrected. The traditional tools of coding theory have come from combinatorics and group theory. Lately, however, coding theorists have added techniques from algebraic geometry to their toolboxes. In particular, by re-interpreting the Reed-Solomon codes, one can see how to define new codes based on divisors on algebraic curves. For instance, using modular curves over finite fields, Tsfasman, Vladut, and Zink showed that one can define a sequence of codes with asymptotically better parameters than any previously known codes. This monograph is based on a series of lectures the author gave as part of the IAS/PCMI program on arithmetic algebraic geometry. Here, the reader is introduced to the exciting field of algebraic geometric coding theory. Presenting the material in the same conversational tone of the lectures, the author covers linear codes, inclu...

Quality control with R an ISO standards approach

CERN Document Server

Cano, Emilio L; Prieto Corcoba, Mariano

2015-01-01

Presenting a practitioner's guide to capabilities and best practices of quality control systems using the R programming language, this volume emphasizes accessibility and ease-of-use through detailed explanations of R code as well as standard statistical methodologies. In the interest of reaching the widest possible audience of quality-control professionals and statisticians, examples throughout are structured to simplify complex equations and data structures, and to demonstrate their applications to quality control processes, such as ISO standards. The volume balances its treatment of key aspects of quality control, statistics, and programming in R, making the text accessible to beginners and expert quality control professionals alike. Several appendices serve as useful references for ISO standards and common tasks performed while applying quality control with R.

Unobtrusive Software and System Health Management with R2U2 on a Parallel MIMD Coprocessor

Science.gov (United States)

Schumann, Johann; Moosbrugger, Patrick

2017-01-01

Dynamic monitoring of software and system health of a complex cyber-physical system requires observers that continuously monitor variables of the embedded software in order to detect anomalies and reason about root causes. There exists a variety of techniques for code instrumentation, but instrumentation might change runtime behavior and could require costly software re-certification. In this paper, we present R2U2E, a novel realization of our real-time, Realizable, Responsive, and Unobtrusive Unit (R2U2). The R2U2E observers are executed in parallel on a dedicated 16-core EPIPHANY co-processor, thereby avoiding additional computational overhead to the system under observation. A DMA-based shared memory access architecture allows R2U2E to operate without any code instrumentation or program interference.

Benchmarking and qualification of the ppercase nufreq -ppercase npw code for best estimate prediction of multichannel core stability margins

International Nuclear Information System (INIS)

Taleyarkhan, R.P.; McFarlane, A.F.; Lahey, R.T. Jr.; Podowski, M.Z.

1994-01-01

The ppercase nufreq - ppercase np (G.C. Park et al. NUREG/CR-3375, 1983; S.J. Peng et al. NUREG/CR-4116, 1984; S.J. Peng et al. Nucl. Sci. Eng. 88 (1988) 404-411) code was modified and set up at Westinghouse, USA, for mixed fuel type multichannel core-wide stability analysis. The resulting code, ppercase nufreq - ppercase npw , allows for variable axial power profiles between channel groups and can handle mixed fuel types.Various models incorporated into ppercase nurfreq - ppercase npw were systematically compared against the Westinghouse channel stability analysis code ppercase mazda -ppercase nf (R. Taleyarkhan et al. J. Heat Transfer 107 (February 1985) 175-181; NUREG/CR2972, 1983), for which the mathematical model was developed in an entirely different manner. Excellent agreement was obtained which verified the thermal-hydraulic modeling and coding aspects. Detailed comparisons were also performed against nuclear-coupled reactor core stability data. All 13 Peach Bottom-2 EOC-2/3 low flow stability tests (L.A. Carmichael and R.O. Neimi, EPRI NP-564, Project 1020-1, 1978; F.B. Woffinden and R.O. Neimi, EPRI, NP 0972, Project 1020-2, 1981) were simulated. A key aspect for code qualification involved the development of a physically based empirical algorithm to correct for the effect of core inlet flow development on subcooled boiling. Various other modeling assumptions were tested and sensitivity studies performed. Good agreement was obtained between ppercase nufreq-npw predictions and data. ((orig.))

Separate Turbo Code and Single Turbo Code Adaptive OFDM Transmissions

Directory of Open Access Journals (Sweden)

Lei Ye

2009-01-01

Full Text Available This paper discusses the application of adaptive modulation and adaptive rate turbo coding to orthogonal frequency-division multiplexing (OFDM, to increase throughput on the time and frequency selective channel. The adaptive turbo code scheme is based on a subband adaptive method, and compares two adaptive systems: a conventional approach where a separate turbo code is used for each subband, and a single turbo code adaptive system which uses a single turbo code over all subbands. Five modulation schemes (BPSK, QPSK, 8AMPM, 16QAM, and 64QAM are employed and turbo code rates considered are 1/2 and 1/3. The performances of both systems with high (10−2 and low (10−4 BER targets are compared. Simulation results for throughput and BER show that the single turbo code adaptive system provides a significant improvement.

A New Prime Code for Synchronous Optical Code Division Multiple-Access Networks

Directory of Open Access Journals (Sweden)

Huda Saleh Abbas

2018-01-01

Full Text Available A new spreading code based on a prime code for synchronous optical code-division multiple-access networks that can be used in monitoring applications has been proposed. The new code is referred to as “extended grouped new modified prime code.” This new code has the ability to support more terminal devices than other prime codes. In addition, it patches subsequences with “0s” leading to lower power consumption. The proposed code has an improved cross-correlation resulting in enhanced BER performance. The code construction and parameters are provided. The operating performance, using incoherent on-off keying modulation and incoherent pulse position modulation systems, has been analyzed. The performance of the code was compared with other prime codes. The results demonstrate an improved performance, and a BER floor of 10−9 was achieved.

Understanding Mixed Code and Classroom Code-Switching: Myths and Realities

Science.gov (United States)

Li, David C. S.

2008-01-01

Background: Cantonese-English mixed code is ubiquitous in Hong Kong society, and yet using mixed code is widely perceived as improper. This paper presents evidence of mixed code being socially constructed as bad language behavior. In the education domain, an EDB guideline bans mixed code in the classroom. Teachers are encouraged to stick to…

Nuclear material control at IEA-R1 nuclear research reactor

International Nuclear Information System (INIS)

1988-01-01

The control measurements system and verification of physical inventory for fuel elements used in the operation of IEA-R1 nuclear research reactor are described. The computer code used for burn-up calculation are shown. (E.G.) [pt

Development of a coupled code system based on system transient code, RETRAN, and 3-D neutronics code, MASTER

International Nuclear Information System (INIS)

Kim, K. D.; Jung, J. J.; Lee, S. W.; Cho, B. O.; Ji, S. K.; Kim, Y. H.; Seong, C. K.

2002-01-01

A coupled code system of RETRAN/MASTER has been developed for best-estimate simulations of interactions between reactor core neutron kinetics and plant thermal-hydraulics by incorporation of a 3-D reactor core kinetics analysis code, MASTER into system transient code, RETRAN. The soundness of the consolidated code system is confirmed by simulating the MSLB benchmark problem developed to verify the performance of a coupled kinetics and system transient codes by OECD/NEA

IGORR-IV workshop on R and D needs

International Nuclear Information System (INIS)

Boening, Klaus

1995-01-01

The IGORR-IV Workshop on R and D Needs, which is the subject of this summarizing paper, provided the opportunity for the participants to report on new R and D needs they have as well as on R and D work which was going on at their home institutions ad which could be of interest to other groups. Numerous topics of interest are: Accident and safety analysis codes and benchmarks; thermophysical properties of D 2 O liquid and vapor; chemical and other energy release from core melt event; Fission product release from a molten MTR core; Thermal conductivity of irradiated fuel; tests of cryogenic circulators for single-phase forced-convection cold source; Flow blockage tests

DOG -II input generator program for DOT3.5 code

International Nuclear Information System (INIS)

Hayashi, Katsumi; Handa, Hiroyuki; Yamada, Koubun; Kamogawa, Susumu; Takatsu, Hideyuki; Koizumi, Kouichi; Seki, Yasushi

1992-01-01

DOT3.5 is widely used for radiation transport analysis of fission reactors, fusion experimental facilities and particle accelerators. We developed the input generator program for DOT3.5 code in aim to prepare input data effectively. Formar program DOG was developed and used internally in Hitachi Engineering Company. In this new version DOG-II, limitation for R-Θ geometry was removed. All the input data is created by interactive method in front of color display without using DOT3.5 manual. Also the geometry related input are easily created without calculation of precise curved mesh point. By using DOG-II, reliable input data for DOT3.5 code is obtained easily and quickly

Exploration of the R code-based mathematical model for PMI estimation using profiling of RNA degradation in rat brain tissue at different temperatures.

Science.gov (United States)

Ma, Jianlong; Pan, Hui; Zeng, Yan; Lv, Yehui; Zhang, Heng; Xue, Aimin; Jiang, Jieqing; Ma, Kaijun; Chen, Long

2015-12-01

Precise estimation of postmortem interval (PMI) is crucial in some criminal cases. This study aims to find some optimal markers for PMI estimation and build a mathematical model that could be used in various temperature conditions. Different mRNA and microRNA markers in rat brain samples were detected using real-time fluorescent quantitative PCR at 12 time points within 144 h postmortem and at temperatures of 4, 15, 25, and 35 °C. Samples from 36 other rats were used to verify the animal mathematical model. Brain-specific mir-9 and mir-125b are effective endogenous control markers that are not affected by PMI up to 144 h postmortem under these temperatures, whereas the commonly used U6 is not a suitable endogenous control in this study. Among all the candidate markers, ΔCt (β-actin) has the best correlation coefficient with PMI and was used to build a new model using R software which can simultaneously manage both PMI and temperature parameters. This animal mathematical model is verified using samples from 36 other rats and shows increased accuracy for higher temperatures and longer PMI. In this study, β-actin was found to be an optimal marker to estimate PMI and some other markers were found to be suitable to act as endogenous controls. Additionally, we have used R code software to build a model of PMI estimation that could be used in various temperature conditions.

QR Codes 101

Science.gov (United States)

Crompton, Helen; LaFrance, Jason; van 't Hooft, Mark

2012-01-01

A QR (quick-response) code is a two-dimensional scannable code, similar in function to a traditional bar code that one might find on a product at the supermarket. The main difference between the two is that, while a traditional bar code can hold a maximum of only 20 digits, a QR code can hold up to 7,089 characters, so it can contain much more…

On the effectiveness of recoding-based repair in network coded distributed storage

DEFF Research Database (Denmark)

Sipos, Marton A.; Braun, Patrik J.; Roetter, Daniel Enrique Lucani

2017-01-01

High capacity storage systems distribute less across several storage devices (nodes) and apply an erasure code to meet availability and reliability requirements. Since devices can lose network connectivity or fail permanently, a dynamic repair mechanism must be put in place. In such cases a new r...

Synergism of the method of characteristic, R-functions and diffusion solution for accurate representation of 3D neutron interactions in research reactors using the AGENT code system

International Nuclear Information System (INIS)

Hursin, Mathieu; Xiao Shanjie; Jevremovic, Tatjana

2006-01-01

This paper summarizes the theoretical and numerical aspects of the AGENT code methodology accurately applied for detailed three-dimensional (3D) multigroup steady-state modeling of neutron interactions in complex heterogeneous reactor domains. For the first time we show the fine-mesh neutron scalar flux distribution in Purdue research reactor (that was built over forty years ago). The AGENT methodology is based on the unique combination of the three theories: the method of characteristics (MOC) used to simulate the neutron transport in two-dimensional (2D) whole core heterogeneous calculation, the theory of R-functions used as a mathematical tool to describe the true geometry and fuse with the MOC equations, and one-dimensional (1D) higher-order diffusion correction of 2D transport model to account for full 3D heterogeneous whole core representation. The synergism between the radial 2D transport and the 1D axial transport (to take into account the axial neutron interactions and leakage), called the 2D/1D method (used in DeCART and CHAPLET codes), provides a 3D computational solution. The unique synergism between the AGENT geometrical algorithm capable of modeling any current or future reactor core geometry and 3D neutron transport methodology is described in details. The 3D AGENT accuracy and its efficiency are demonstrated showing the eigenvalues, point-wise flux and reaction rate distributions in representative reactor geometries. The AGENT code, comprising this synergism, represents a building block of the computational system, called the virtual reactor. Its main purpose is to perform 'virtual' experiments and demonstrations of various mainly university research reactor experiments

Development of a code in three-dimensional cylindrical geometry based on analytic function expansion nodal (AFEN) method

International Nuclear Information System (INIS)

Lee, Joo Hee

2006-02-01

There is growing interest in developing pebble bed reactors (PBRs) as a candidate of very high temperature gas-cooled reactors (VHTRs). Until now, most existing methods of nuclear design analysis for this type of reactors are base on old finite-difference solvers or on statistical methods. But for realistic analysis of PBRs, there is strong desire of making available high fidelity nodal codes in three-dimensional (r,θ,z) cylindrical geometry. Recently, the Analytic Function Expansion Nodal (AFEN) method developed quite extensively in Cartesian (x,y,z) geometry and in hexagonal-z geometry was extended to two-group (r,z) cylindrical geometry, and gave very accurate results. In this thesis, we develop a method for the full three-dimensional cylindrical (r,θ,z) geometry and implement the method into a code named TOPS. The AFEN methodology in this geometry as in hexagonal geometry is 'robus' (e.g., no occurrence of singularity), due to the unique feature of the AFEN method that it does not use the transverse integration. The transverse integration in the usual nodal methods, however, leads to an impasse, that is, failure of the azimuthal term to be transverse-integrated over r-z surface. We use 13 nodal unknowns in an outer node and 7 nodal unknowns in an innermost node. The general solution of the node can be expressed in terms of that nodal unknowns, and can be updated using the nodal balance equation and the current continuity condition. For more realistic analysis of PBRs, we implemented em Marshak boundary condition to treat the incoming current zero boundary condition and the partial current translation (PCT) method to treat voids in the core. The TOPS code was verified in the various numerical tests derived from Dodds problem and PBMR-400 benchmark problem. The results of the TOPS code show high accuracy and fast computing time than the VENTURE code that is based on finite difference method (FDM)

Assessment of a RELAP5 model for the IPR-R1 TRIGA research reactor

International Nuclear Information System (INIS)

Reis, Patricia A.L.; Costa, Antonella L.; Pereira, Claubia; Veloso, Maria A.F.; Mesquita, Amir Z.; Soares, Humberto V.

2010-01-01

RELAP5 code was developed at the Idaho National Environmental and Engineering Laboratory and it is widely used for thermal hydraulic studies of commercial nuclear power plants and, currently, it has been also applied for thermal hydraulic analysis of nuclear research systems with good predictions. This work is a contribution to the assessment of RELAP5/3.3 code for research reactors analysis. It presents steady-state and transient calculation results performed using a RELAP5 model to simulate the IPR-R1 TRIGA research reactor conditions operating at 50 and 100 kW. The reactor is located at the Nuclear Technology Development Centre (CDTN), Brazil. The development and the assessment of a RELAP5 model for the IPR-R1 TRIGA are presented. Experimental data were considered in the process of code-to-data validation. The RELAP5 results were also compared with calculation performed using the STHIRP-1 (Research Reactors Thermal Hydraulic Simulation) code. The use of a cross flow model has been essential to improve results in the transient condition respect to preceding investigations.

26 CFR 31.3306(r)(2)-1 - Treatment of amounts deferred under certain nonqualified deferred compensation plans.

Science.gov (United States)

2010-04-01

... nonqualified deferred compensation plans. 31.3306(r)(2)-1 Section 31.3306(r)(2)-1 Internal Revenue INTERNAL..., Internal Revenue Code of 1954) § 31.3306(r)(2)-1 Treatment of amounts deferred under certain nonqualified deferred compensation plans. (a) In general. Section 3306(r)(2) provides a special timing rule for the tax...

Some Families of Asymmetric Quantum MDS Codes Constructed from Constacyclic Codes

Science.gov (United States)

Huang, Yuanyuan; Chen, Jianzhang; Feng, Chunhui; Chen, Riqing

2018-02-01

Quantum maximal-distance-separable (MDS) codes that satisfy quantum Singleton bound with different lengths have been constructed by some researchers. In this paper, seven families of asymmetric quantum MDS codes are constructed by using constacyclic codes. We weaken the case of Hermitian-dual containing codes that can be applied to construct asymmetric quantum MDS codes with parameters [[n,k,dz/dx

Systematic Luby Transform codes as incremental redundancy scheme

CSIR Research Space (South Africa)

Grobler, TL

2011-09-01

Full Text Available Transform Codes as Incremental Redundancy Scheme T. L. Grobler y, E. R. Ackermann y, J. C. Olivier y and A. J. van Zylz Department of Electrical, Electronic and Computer Engineering University of Pretoria, Pretoria 0002, South Africa Email: trienkog...@gmail.com, etienne.ackermann@ieee.org yDefence, Peace, Safety and Security (DPSS) Council for Scientific and Industrial Research (CSIR), Pretoria 0001, South Africa zDepartment of Mathematics and Applied Mathematics University of Pretoria, Pretoria 0002, South...

Theoretical Atomic Physics code development II: ACE: Another collisional excitation code

International Nuclear Information System (INIS)

Clark, R.E.H.; Abdallah, J. Jr.; Csanak, G.; Mann, J.B.; Cowan, R.D.

1988-12-01

A new computer code for calculating collisional excitation data (collision strengths or cross sections) using a variety of models is described. The code uses data generated by the Cowan Atomic Structure code or CATS for the atomic structure. Collisional data are placed on a random access file and can be displayed in a variety of formats using the Theoretical Atomic Physics Code or TAPS. All of these codes are part of the Theoretical Atomic Physics code development effort at Los Alamos. 15 refs., 10 figs., 1 tab

Multiple LDPC decoding for distributed source coding and video coding

DEFF Research Database (Denmark)

Forchhammer, Søren; Luong, Huynh Van; Huang, Xin

2011-01-01

Distributed source coding (DSC) is a coding paradigm for systems which fully or partly exploit the source statistics at the decoder to reduce the computational burden at the encoder. Distributed video coding (DVC) is one example. This paper considers the use of Low Density Parity Check Accumulate...... (LDPCA) codes in a DSC scheme with feed-back. To improve the LDPC coding performance in the context of DSC and DVC, while retaining short encoder blocks, this paper proposes multiple parallel LDPC decoding. The proposed scheme passes soft information between decoders to enhance performance. Experimental...

Implementation of Neutronics Analysis Code using the Features of Object Oriented Programming via Fortran90/95

Energy Technology Data Exchange (ETDEWEB)

Han, Tae Young; Cho, Beom Jin [KEPCO Nuclear Fuel, Daejeon (Korea, Republic of)

2011-05-15

The object-oriented programming (OOP) concept was radically established after 1990s and successfully involved in Fortran 90/95. The features of OOP are such as the information hiding, encapsulation, modularity and inheritance, which lead to producing code that satisfy three R's: reusability, reliability and readability. The major OOP concepts, however, except Module are not mainly used in neutronics analysis codes even though the code was written by Fortran 90/95. In this work, we show that the OOP concept can be employed to develop the neutronics analysis code, ASTRA1D (Advanced Static and Transient Reactor Analyzer for 1-Dimension), via Fortran90/95 and those can be more efficient and reasonable programming methods

Neutronic parameters characterization of the TRIGA IPR-R1 using scale 6.0 (KENO VI)

Energy Technology Data Exchange (ETDEWEB)

Faria, Victor; Miro, Rafael; Verdu, Gumersindo; Barrachina, Teresa [Institute for Industrial, Radiophysical and Environmental Safety (ISIRYM), Universitat Politecnica de València (Spain); Silva, Clarysson A. Mello da; Pereira, Claubia [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Departamento de Engenharia Nuclear; Dalle, Hugo Moura [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

2011-07-01

KENO-VI is a Monte Carlo based transport code used to obtain the criticality of a nuclear system. A model built using this code in the SCALE6.0 software system was developed for the characterization of neutronic parameters of the IPR-R1 TRIGA research reactor. A comparison with experimental values and those calculated with a MCNP code model could be then attained with the purpose to validate this methodology. (author)

Neutronic parameters characterization of the TRIGA IPR-R1 using scale 6.0 (KENO VI)

International Nuclear Information System (INIS)

Faria, Victor; Miro, Rafael; Verdu, Gumersindo; Barrachina, Teresa; Silva, Clarysson A. Mello da; Pereira, Claubia

2011-01-01

KENO-VI is a Monte Carlo based transport code used to obtain the criticality of a nuclear system. A model built using this code in the SCALE6.0 software system was developed for the characterization of neutronic parameters of the IPR-R1 TRIGA research reactor. A comparison with experimental values and those calculated with a MCNP code model could be then attained with the purpose to validate this methodology. (author)

Accuracy of rate coding: When shorter time window and higher spontaneous activity help

Czech Academy of Sciences Publication Activity Database

Leváková, Marie; Tamborrino, M.; Košťál, Lubomír; Lánský, Petr

2017-01-01

Roč. 95, č. 2 (2017), č. článku 022310. ISSN 2470-0045 R&D Projects: GA ČR(CZ) GA15-08066S; GA MŠk(CZ) 7AMB17AT048 Institutional support: RVO:67985823 Keywords : rate coding * observation window * spontaneous activity * Fisher information * perfect integrate- and -fire model * Wiener process Subject RIV: BB - Applied Statistics, Operational Research OBOR OECD: Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology Impact factor: 2.366, year: 2016

Large-eddy simulation of stratified atmospheric flows with the CFD code Code-Saturne

International Nuclear Information System (INIS)

Dall'Ozzo, Cedric

2013-01-01

Large-eddy simulation (LES) of the physical processes in the atmospheric boundary layer (ABL) remains a complex subject. LES models have difficulties to capture the evolution of the turbulence in different conditions of stratification. Consequently, LES of the whole diurnal cycle of the ABL including convective situations in daytime and stable situations in the nighttime is seldom documented. The simulation of the stable atmospheric boundary layer which is characterized by small eddies and by weak and sporadic turbulence is especially difficult. Therefore The LES ability to well reproduce real meteorological conditions, particularly in stable situations, is studied with the CFD code developed by EDF R and D, Code-Saturne. The first study consist in validate LES on a quasi-steady state convective case with homogeneous terrain. The influence of the sub-grid-scale models (Smagorinsky model, Germano-Lilly model, Wong-Lilly model and Wall-Adapting Local Eddy-viscosity model) and the sensitivity to the parametrization method on the mean fields, flux and variances are discussed. In a second study, the diurnal cycle of the ABL during Wangara experiment is simulated. The deviation from the measurement is weak during the day, so this work is focused on the difficulties met during the night to simulate the stable atmospheric boundary layer. The impact of the different sub-grid-scale models and the sensitivity to the Smagorinsky constant are been analysed. By coupling radiative forcing with LES, the consequences of infra-red and solar radiation on the nocturnal low level jet and on thermal gradient, close to the surface, are exposed. More, enhancement of the domain resolution to the turbulence intensity and the strong atmospheric stability during the Wangara experiment are analysed. Finally, a study of the numerical oscillations inherent to Code-Saturne is realized in order to decrease their effects. (author) [fr

VAMPIR - A two-group two-dimensional diffusion computer code for burnup calculation

International Nuclear Information System (INIS)

Zmijarevic, I.; Petrovic, I.

1985-01-01

VAMPIR is a computer code which simulates the burnup within a reactor coe. It computes the neutron flux, power distribution and burnup taking into account spatial variations of temperature and xenon poisoning. Its overall reactor calculation uses diffusion theory with finite differences approximation in X-Y or R-Z geometry. Two-group macroscopic cross section data are prepared by the lattice cell code WIMS-D4 and stored in the library form of multi entry tabulation against the various parameters that significantly affect the physical conditions in the reactor core. herein, the main features of the program are presented. (author)

Error-correction coding and decoding bounds, codes, decoders, analysis and applications

CERN Document Server

Tomlinson, Martin; Ambroze, Marcel A; Ahmed, Mohammed; Jibril, Mubarak

2017-01-01

This book discusses both the theory and practical applications of self-correcting data, commonly known as error-correcting codes. The applications included demonstrate the importance of these codes in a wide range of everyday technologies, from smartphones to secure communications and transactions. Written in a readily understandable style, the book presents the authors’ twenty-five years of research organized into five parts: Part I is concerned with the theoretical performance attainable by using error correcting codes to achieve communications efficiency in digital communications systems. Part II explores the construction of error-correcting codes and explains the different families of codes and how they are designed. Techniques are described for producing the very best codes. Part III addresses the analysis of low-density parity-check (LDPC) codes, primarily to calculate their stopping sets and low-weight codeword spectrum which determines the performance of these codes. Part IV deals with decoders desi...

Test and intercomparisons of data fitting with general least squares code GMA versus Bayesian code GLUCS

International Nuclear Information System (INIS)

Pronyaev, V.G.

2003-01-01

Data fitting with GMA and GLUCS gives consistent results. Difference in the evaluated central values obtained with different formalisms can be related to the general accuracy with which fits could be done in different formalisms. It has stochastic nature and should be accounted in the final results of the data evaluation as small SERC uncertainty. Some shift in central values of data evaluated with GLUCS and GMA relative the central values evaluated with the R-matrix model code RAC is observed for cases of fitting strongly varying data and is related to the PPP. The procedure of evaluation, free from PPP, should be elaborated. (author)

Transgenic miR132 alters neuronal spine density and impairs novel object recognition memory.

Directory of Open Access Journals (Sweden)

Katelin F Hansen

2010-11-01

Full Text Available Inducible gene expression plays a central role in neuronal plasticity, learning, and memory, and dysfunction of the underlying molecular events can lead to severe neuronal disorders. In addition to coding transcripts (mRNAs, non-coding microRNAs (miRNAs appear to play a role in these processes. For instance, the CREB-regulated miRNA miR132 has been shown to affect neuronal structure in an activity-dependent manner, yet the details of its physiological effects and the behavioral consequences in vivo remain unclear. To examine these questions, we employed a transgenic mouse strain that expresses miR132 in forebrain neurons. Morphometric analysis of hippocampal neurons revealed that transgenic miR132 triggers a marked increase in dendritic spine density. Additionally, miR132 transgenic mice exhibited a decrease in the expression of MeCP2, a protein implicated in Rett Syndrome and other disorders of mental retardation. Consistent with these findings, miR132 transgenic mice displayed significant deficits in novel object recognition. Together, these data support a role for miR132 as a regulator of neuronal structure and function, and raise the possibility that dysregulation of miR132 could contribute to an array of cognitive disorders.

Error floor behavior study of LDPC codes for concatenated codes design

Science.gov (United States)

Chen, Weigang; Yin, Liuguo; Lu, Jianhua

2007-11-01

Error floor behavior of low-density parity-check (LDPC) codes using quantized decoding algorithms is statistically studied with experimental results on a hardware evaluation platform. The results present the distribution of the residual errors after decoding failure and reveal that the number of residual error bits in a codeword is usually very small using quantized sum-product (SP) algorithm. Therefore, LDPC code may serve as the inner code in a concatenated coding system with a high code rate outer code and thus an ultra low error floor can be achieved. This conclusion is also verified by the experimental results.

Thermal hydraulic analysis of the IPR-R1 TRIGA research reactor using a RELAP5 model

International Nuclear Information System (INIS)

Costa, Antonella L.; Reis, Patricia Amelia L.; Pereira, Claubia; Veloso, Maria Auxiliadora F.; Mesquita, Amir Z.; Soares, Humberto V.

2010-01-01

The RELAP5 code is widely used for thermal hydraulic studies of commercial nuclear power plants. Current investigations and code adaptations have demonstrated that the RELAP5 code can be also applied for thermal hydraulic analysis of nuclear research reactors with good predictions. Therefore, as a contribution to the assessment of RELAP5/MOD3.3 for research reactors analysis, this work presents steady-state and transient calculation results performed using a RELAP5 model to simulate the IPR-R1 TRIGA research reactor at 50 kilowatts (kW) of power operation. The reactor is located in the Nuclear Technology Development Center (CDTN), Brazil. It is a 250 kW, light water moderated and cooled, graphite-reflected, open pool type research reactor. The development and the assessment of a RELAP5 model for the IPR-R1 TRIGA are presented. Experimental data were considered in the process of the RELAP5 model validation. The RELAP5 results were also compared with calculated data from the STHIRP-1 (Research Reactors Thermal Hydraulic Simulation) code. The results obtained have shown that the RELAP5 model for the IPR-R1 TRIGA reproduces the actual steady-state reactor behavior in good agreement with the available data.

RSEIS and RFOC: Seismic Analysis in R

Science.gov (United States)

Lees, J. M.

2015-12-01

Open software is essential for reproducible scientific exchange. R-packages provide a platform for development of seismological investigation software that can be properly documented and traced for data processing. A suite of R packages designed for a wide range of seismic analysis is currently available in the free software platform called R. R is a software platform based on the S-language developed at Bell Labs decades ago. Routines in R can be run as standalone function calls, or developed in object-oriented mode. R comes with a base set of routines, and thousands of user developed packages. The packages developed at UNC include subroutines and interactive codes for processing seismic data, analyzing geographic information (GIS) and inverting data involved in a variety of geophysical applications. On CRAN (Comprehensive R Archive Network, http://www.r-project.org/) currently available packages related to seismic analysis are RSEIS, Rquake, GEOmap, RFOC, zoeppritz, RTOMO, and geophys, Rwave, PEIP, hht, rFDSN. These include signal processing, data management, mapping, earthquake location, deconvolution, focal mechanisms, wavelet transforms, Hilbert-Huang Transforms, tomographic inversion, and Mogi deformation among other useful functionality. All software in R packages is required to have detailed documentation, making the exchange and modification of existing software easy. In this presentation, I will focus on packages RSEIS and RFOC, showing examples from a variety of seismic analyses. The R approach has similarities to the popular (and expensive) MATLAB platform, although R is open source and free to down load.

Decree No85-968 of 27 August 1986 amending Article R.233-83 of the Labour Code and defining the health and safety conditions to be met by gamma industrial radiography equipment

International Nuclear Information System (INIS)

1986-01-01

This Decree, amending Article R 233-83 of the Labour Code, applies to gamma-ray industrial radiography equipment whether mobile or fixed. It contains specific technical conditions concerning the equipment, in particular, safety devices located at the entry and exit points of the source's shield. The equipment must carry a notice mentioning''Radioactive''prepared by the constructor or the importer of the source, which explains the conditions for handling, setting-up, use and maintenance of the source, including the frequency of revisions. The Decree entered into force on 1 June 1986. (NEA) [fr

Reactor lattice codes

International Nuclear Information System (INIS)

Kulikowska, T.

1999-01-01

The present lecture has a main goal to show how the transport lattice calculations are realised in a standard computer code. This is illustrated on the example of the WIMSD code, belonging to the most popular tools for reactor calculations. Most of the approaches discussed here can be easily modified to any other lattice code. The description of the code assumes the basic knowledge of reactor lattice, on the level given in the lecture on 'Reactor lattice transport calculations'. For more advanced explanation of the WIMSD code the reader is directed to the detailed descriptions of the code cited in References. The discussion of the methods and models included in the code is followed by the generally used homogenisation procedure and several numerical examples of discrepancies in calculated multiplication factors based on different sources of library data. (author)

Investigating effects of boundary conditions on the evaluation of R-factor of un-braced steel frames

Directory of Open Access Journals (Sweden)

Masood M.M. Irheem

2017-08-01

Full Text Available Design of Structures to resist seismic load depends on the theory of dissipation in elastic of energy that already exists in response modification factor “R-factor”. The main problem in codes gives a constant value for R-factor, since change in boundary conditions of building change in behavior of steel frame structures and that effect on R-factor. This study is an attempt to assess overstrength, ductility and response modification factor of un-braced steel frames under change in boundary conditions as change in the direction of strong axis of column and support type beside to variation in story and bay number to be 9 frame and each frame has 8 different boundary conditions as sum of 72 case for analysis. These frames were analyzed by using nonlinear static “pushover” analysis using SAP2000 program. As a result of this study R-factor does not has a constant value, when change in boundary conditions R-factor directly changes, minimum value of 8 boundary conditions is close to the code value that is mean the code is more conservative and give a large factor of safety. Ductility reduction factor increases with increasing number of story for all boundary conditions, but overstrength has different rule. Response modification factor, overstrength factor and ductility reduction factor decrease when fundamentals period increasing for the studied frames.

TIMS-1: a processing code for production of group constants of heavy resonant nuclei

International Nuclear Information System (INIS)

Takano, Hideki; Ishiguro, Yukio; Matsui, Yasushi.

1980-09-01

The TIMS-1 code calculates the infinitely dilute group cross sections and the temperature dependent self-shielding factors for arbitrary values of σ 0 and R, where σ 0 is the effective background cross section of potential scattering and R the ratio of the atomic number densities for two resonant nuclei if any. This code is specifically programmed to use the evaluated nuclear data file of ENDF/B or JENDL as input data. In the unresolved resonance region, the resonance parameters and the level spacings are generated by using Monte Carlo method from the Porter-Thomas and Wigner distributions respectively. The Doppler broadened cross sections are calculated on the ultra-fine lethargy meshes of about 10 -3 -- 10 -5 using the generated and resolved resonance parameters. The effective group constants are calculated by solving the neutron slowing down equation with the use of the recurrence formula for the neutron slowing down source. The output of the calculated results is given in a format being consistent with the JAERI-Fast set (JFS) or the Standard Reactor Analysis Code (SRAC) library. Both FACOM 230/75 and M200 versions of TIMS-1 are available. (author)

CodeArmor : Virtualizing the Code Space to Counter Disclosure Attacks

NARCIS (Netherlands)

Chen, Xi; Bos, Herbert; Giuffrida, Cristiano

2017-01-01

Code diversification is an effective strategy to prevent modern code-reuse exploits. Unfortunately, diversification techniques are inherently vulnerable to information disclosure. Recent diversification-aware ROP exploits have demonstrated that code disclosure attacks are a realistic threat, with an

An Evaluation of Automated Code Generation with the PetriCode Approach

DEFF Research Database (Denmark)

Simonsen, Kent Inge

2014-01-01

Automated code generation is an important element of model driven development methodologies. We have previously proposed an approach for code generation based on Coloured Petri Net models annotated with textual pragmatics for the network protocol domain. In this paper, we present and evaluate thr...... important properties of our approach: platform independence, code integratability, and code readability. The evaluation shows that our approach can generate code for a wide range of platforms which is integratable and readable....

IL6R Variation Asp358Ala Is a Potential Modifier of Lung Function in Asthma

Science.gov (United States)

Hawkins, Gregory A; Robinson, Mac B; Hastie, Annette T; Li, Xingnan; Li, Huashi; Moore, Wendy C; Howard, Timothy D; Busse, William W.; Erzurum, Serpil C.; Wenzel, Sally E.; Peters, Stephen P; Meyers, Deborah A; Bleecker, Eugene R

2012-01-01

Background The IL6R SNP rs4129267 has recently been identified as an asthma susceptibility locus in subjects of European ancestry but has not been characterized with respect to asthma severity. The SNP rs4129267 is in linkage disequilibrium (r2=1) with the IL6R coding SNP rs2228145 (Asp358Ala). This IL6R coding change increases IL6 receptor shedding and promotes IL6 transsignaling. Objectives To evaluate the IL6R SNP rs2228145 with respect to asthma severity phenotypes. Methods The IL6R SNP rs2228145 was evaluated in subjects of European ancestry with asthma from the Severe Asthma Research Program (SARP). Lung function associations were replicated in the Collaborative Study on the Genetics of Asthma (CSGA) cohort. Serum soluble IL6 receptor (sIL6R) levels were measured in subjects from SARP. Immunohistochemistry was used to qualitatively evaluate IL6R protein expression in BAL cells and endobronchial biopsies. Results The minor C allele of IL6R SNP rs2228145 was associated with lower ppFEV1 in the SARP cohort (p=0.005), the CSGA cohort (0.008), and in combined cohort analysis (p=0.003). Additional associations with ppFVC, FEV1/FVC, and PC20 were observed. The rs2228145 C allele (Ala358) was more frequent in severe asthma phenotypic clusters. Elevated serum sIL6R was associated with lower ppFEV1 (p=0.02) and lower ppFVC (p=0.008) (N=146). IL6R protein expression was observed in BAL macrophages, airway epithelium, vascular endothelium, and airway smooth muscle. Conclusions The IL6R coding SNP rs2228145 (Asp358Ala) is a potential modifier of lung function in asthma and may identify subjects at risk for more severe asthma. IL6 transsignaling may have a pathogenic role in the lung. PMID:22554704

MiR-218 Mediates tumorigenesis and metastasis: Perspectives and implications

Energy Technology Data Exchange (ETDEWEB)

Lu, Ying-fei [Institute Guangzhou of Advanced Technology, Chinese Academy of Sciences, Guangzhou (China); Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong (China); Zhang, Li [School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong (China); Department of Anatomical and Cellular Pathology, State Key Laboratory of Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong (China); Waye, Mary Miu Yee [School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong (China); Fu, Wei-ming, E-mail: wm.fu@giat.ac.cn [Institute Guangzhou of Advanced Technology, Chinese Academy of Sciences, Guangzhou (China); School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong (China); Zhang, Jin-fang, E-mail: zhangjf06@cuhk.edu.hk [Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong (China); School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong (China); Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen (China)

2015-05-15

MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. As a highly conserved miRNA across a variety of species, microRNA-218 (miR-218) was found to play pivotal roles in tumorigenesis and progression. A group of evidence has demonstrated that miR-218 acts as a tumor suppressor by targeting many oncogenes related to proliferation, apoptosis and invasion. In this review, we provide a complex overview of miR-218, including its regulatory mechanisms, known functions in cancer and future challenges as a potential therapeutic target in human cancers. - Highlights: • miR-218 is frequently down regulated in multiple cancers. • miR-218 plays pivotal roles in carcinogenesis. • miR-218 mediates proliferation, apoptosis, metastasis, invasion, etc. • miR-218 mediates tumorigenesis and metastasis via multiple pathways.

MiR-218 Mediates tumorigenesis and metastasis: Perspectives and implications

International Nuclear Information System (INIS)

Lu, Ying-fei; Zhang, Li; Waye, Mary Miu Yee; Fu, Wei-ming; Zhang, Jin-fang

2015-01-01

MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. As a highly conserved miRNA across a variety of species, microRNA-218 (miR-218) was found to play pivotal roles in tumorigenesis and progression. A group of evidence has demonstrated that miR-218 acts as a tumor suppressor by targeting many oncogenes related to proliferation, apoptosis and invasion. In this review, we provide a complex overview of miR-218, including its regulatory mechanisms, known functions in cancer and future challenges as a potential therapeutic target in human cancers. - Highlights: • miR-218 is frequently down regulated in multiple cancers. • miR-218 plays pivotal roles in carcinogenesis. • miR-218 mediates proliferation, apoptosis, metastasis, invasion, etc. • miR-218 mediates tumorigenesis and metastasis via multiple pathways

Advanced video coding systems

CERN Document Server

Gao, Wen

2015-01-01

This comprehensive and accessible text/reference presents an overview of the state of the art in video coding technology. Specifically, the book introduces the tools of the AVS2 standard, describing how AVS2 can help to achieve a significant improvement in coding efficiency for future video networks and applications by incorporating smarter coding tools such as scene video coding. Topics and features: introduces the basic concepts in video coding, and presents a short history of video coding technology and standards; reviews the coding framework, main coding tools, and syntax structure of AV

Cracking the code: the accuracy of coding shoulder procedures and the repercussions.

Science.gov (United States)

Clement, N D; Murray, I R; Nie, Y X; McBirnie, J M

2013-05-01

Coding of patients' diagnosis and surgical procedures is subject to error levels of up to 40% with consequences on distribution of resources and financial recompense. Our aim was to explore and address reasons behind coding errors of shoulder diagnosis and surgical procedures and to evaluate a potential solution. A retrospective review of 100 patients who had undergone surgery was carried out. Coding errors were identified and the reasons explored. A coding proforma was designed to address these errors and was prospectively evaluated for 100 patients. The financial implications were also considered. Retrospective analysis revealed the correct primary diagnosis was assigned in 54 patients (54%) had an entirely correct diagnosis, and only 7 (7%) patients had a correct procedure code assigned. Coders identified indistinct clinical notes and poor clarity of procedure codes as reasons for errors. The proforma was significantly more likely to assign the correct diagnosis (odds ratio 18.2, p code (odds ratio 310.0, p coding department. High error levels for coding are due to misinterpretation of notes and ambiguity of procedure codes. This can be addressed by allowing surgeons to assign the diagnosis and procedure using a simplified list that is passed directly to coding.

An open-source textbook for teaching climate-related risk analysis using the R computing environment

Science.gov (United States)

Applegate, P. J.; Keller, K.

2015-12-01

Greenhouse gas emissions lead to increased surface air temperatures and sea level rise. In turn, sea level rise increases the risks of flooding for people living near the world's coastlines. Our own research on assessing sea level rise-related risks emphasizes both Earth science and statistics. At the same time, the free, open-source computing environment R is growing in popularity among statisticians and scientists due to its flexibility and graphics capabilities, as well as its large library of existing functions. We have developed a set of laboratory exercises that introduce students to the Earth science and statistical concepts needed for assessing the risks presented by climate change, particularly sea-level rise. These exercises will be published as a free, open-source textbook on the Web. Each exercise begins with a description of the Earth science and/or statistical concepts that the exercise teaches, with references to key journal articles where appropriate. Next, students are asked to examine in detail a piece of existing R code, and the exercise text provides a clear explanation of how the code works. Finally, students are asked to modify the existing code to produce a well-defined outcome. We discuss our experiences in developing the exercises over two separate semesters at Penn State, plus using R Markdown to interweave explanatory text with sample code and figures in the textbook.

Iterative Phase Optimization of Elementary Quantum Error Correcting Codes (Open Access, Publisher’s Version)

Science.gov (United States)

2016-08-24

to the seven-qubit Steane code [29] and also represents the smallest instance of a 2D topological color code [30]. Since the realized quantum error...Quantum Computations on a Topologically Encoded Qubit, Science 345, 302 (2014). [17] M. Cramer, M. B. Plenio, S. T. Flammia, R. Somma, D. Gross, S. D...Memory, J. Math . Phys. (N.Y.) 43, 4452 (2002). [20] B. M. Terhal, Quantum Error Correction for Quantum Memories, Rev. Mod. Phys. 87, 307 (2015). [21] D

Los Alamos neutral particle transport codes: New and enhanced capabilities

International Nuclear Information System (INIS)

Alcouffe, R.E.; Baker, R.S.; Brinkley, F.W.; Clark, B.A.; Koch, K.R.; Marr, D.R.

1992-01-01

We present new developments in Los Alamos discrete-ordinates transport codes and introduce THREEDANT, the latest in the series of Los Alamos discrete ordinates transport codes. THREEDANT solves the multigroup, neutral-particle transport equation in X-Y-Z and R-Θ-Z geometries. THREEDANT uses computationally efficient algorithms: Diffusion Synthetic Acceleration (DSA) is used to accelerate the convergence of transport iterations, the DSA solution is accelerated using the multigrid technique. THREEDANT runs on a wide range of computers, from scientific workstations to CRAY supercomputers. The algorithms are highly vectorized on CRAY computers. Recently, the THREEDANT transport algorithm was implemented on the massively parallel CM-2 computer, with performance that is comparable to a single-processor CRAY-YMP We present the results of THREEDANT analysis of test problems

Reliability Data Handbook for Piping Components in Nordic Nuclear Power Plants - R Book, Phase 2

International Nuclear Information System (INIS)

Hedtjaern Swaling, Vidar; Olsson, Anders

2011-02-01

This report presents results of a long research and development project financed by the regulatory body Straalsaekerhetsmyndigheten (SSM) (former SKI), the Swedish nuclear power plant licensees. The report presents a harmonized method for estimating Reliability Data for Piping Components in ASME code class 1 and 2 piping components (R-Book). Data in the R-Book is measured based on 'data driven' strategy. This first version of the R-Book comprises rupture frequencies and failure rates for all systems where ASME Code Class 1 or 2 events could be found in the OECD OPDE database. Nordic and Non-Nordic data are presented separately. Worldwide experience data is used to set up the relevant calculation cases, i.e. intersections of attributes for which there are at least one event present

Construction of new quantum MDS codes derived from constacyclic codes

Science.gov (United States)

Taneja, Divya; Gupta, Manish; Narula, Rajesh; Bhullar, Jaskaran

Obtaining quantum maximum distance separable (MDS) codes from dual containing classical constacyclic codes using Hermitian construction have paved a path to undertake the challenges related to such constructions. Using the same technique, some new parameters of quantum MDS codes have been constructed here. One set of parameters obtained in this paper has achieved much larger distance than work done earlier. The remaining constructed parameters of quantum MDS codes have large minimum distance and were not explored yet.

Effect of tcdR Mutation on Sporulation in the Epidemic Clostridium difficile Strain R20291.

Science.gov (United States)

Girinathan, Brintha P; Monot, Marc; Boyle, Daniel; McAllister, Kathleen N; Sorg, Joseph A; Dupuy, Bruno; Govind, Revathi

2017-01-01

Clostridium difficile is an important nosocomial pathogen and the leading cause of hospital-acquired diarrhea. Antibiotic use is the primary risk factor for the development of C. difficile -associated disease because it disrupts normally protective gut flora and enables C. difficile to colonize the colon. C. difficile damages host tissue by secreting toxins and disseminates by forming spores. The toxin-encoding genes, tcdA and tcdB , are part of a pathogenicity locus, which also includes the tcdR gene that codes for TcdR, an alternate sigma factor that initiates transcription of tcdA and tcdB genes. We created a tcdR mutant in epidemic-type C. difficile strain R20291 in an attempt to identify the global role of tcdR . A site-directed mutation in tcdR affected both toxin production and sporulation in C. difficile R20291. Spores of the tcdR mutant were more heat sensitive than the wild type (WT). Nearly 3-fold more taurocholate was needed to germinate spores from the tcdR mutant than to germinate the spores prepared from the WT strain. Transmission electron microscopic analysis of the spores also revealed a weakly assembled exosporium on the tcdR mutant spores. Accordingly, comparative transcriptome analysis showed many differentially expressed sporulation genes in the tcdR mutant compared to the WT strain. These data suggest that regulatory networks of toxin production and sporulation in C. difficile strain R20291 a re linked with each other. IMPORTANCE C. difficile infects thousands of hospitalized patients every year, causing significant morbidity and mortality. C. difficile spores play a pivotal role in the transmission of the pathogen in the hospital environment. During infection, the spores germinate, and the vegetative bacterial cells produce toxins that damage host tissue. Thus, sporulation and toxin production are two important traits of C. difficile . In this study, we showed that a mutation in tcdR , the toxin gene regulator, affects both toxin

Vector Network Coding Algorithms

OpenAIRE

Ebrahimi, Javad; Fragouli, Christina

2010-01-01

We develop new algebraic algorithms for scalar and vector network coding. In vector network coding, the source multicasts information by transmitting vectors of length L, while intermediate nodes process and combine their incoming packets by multiplying them with L x L coding matrices that play a similar role as coding c in scalar coding. Our algorithms for scalar network jointly optimize the employed field size while selecting the coding coefficients. Similarly, for vector coding, our algori...

Code-Mixing and Code Switchingin The Process of Learning

Directory of Open Access Journals (Sweden)

Diyah Atiek Mustikawati

2016-09-01

Full Text Available This study aimed to describe a form of code switching and code mixing specific form found in the teaching and learning activities in the classroom as well as determining factors influencing events stand out that form of code switching and code mixing in question.Form of this research is descriptive qualitative case study which took place in Al Mawaddah Boarding School Ponorogo. Based on the analysis and discussion that has been stated in the previous chapter that the form of code mixing and code switching learning activities in Al Mawaddah Boarding School is in between the use of either language Java language, Arabic, English and Indonesian, on the use of insertion of words, phrases, idioms, use of nouns, adjectives, clauses, and sentences. Code mixing deciding factor in the learning process include: Identification of the role, the desire to explain and interpret, sourced from the original language and its variations, is sourced from a foreign language. While deciding factor in the learning process of code, includes: speakers (O1, partners speakers (O2, the presence of a third person (O3, the topic of conversation, evoke a sense of humour, and just prestige. The significance of this study is to allow readers to see the use of language in a multilingual society, especially in AL Mawaddah boarding school about the rules and characteristics variation in the language of teaching and learning activities in the classroom. Furthermore, the results of this research will provide input to the ustadz / ustadzah and students in developing oral communication skills and the effectiveness of teaching and learning strategies in boarding schools.

Using Coding Apps to Support Literacy Instruction and Develop Coding Literacy

Science.gov (United States)

Hutchison, Amy; Nadolny, Larysa; Estapa, Anne

2016-01-01

In this article the authors present the concept of Coding Literacy and describe the ways in which coding apps can support the development of Coding Literacy and disciplinary and digital literacy skills. Through detailed examples, we describe how coding apps can be integrated into literacy instruction to support learning of the Common Core English…

Low Complexity List Decoding for Polar Codes with Multiple CRC Codes

Directory of Open Access Journals (Sweden)

Jong-Hwan Kim

2017-04-01

Full Text Available Polar codes are the first family of error correcting codes that provably achieve the capacity of symmetric binary-input discrete memoryless channels with low complexity. Since the development of polar codes, there have been many studies to improve their finite-length performance. As a result, polar codes are now adopted as a channel code for the control channel of 5G new radio of the 3rd generation partnership project. However, the decoder implementation is one of the big practical problems and low complexity decoding has been studied. This paper addresses a low complexity successive cancellation list decoding for polar codes utilizing multiple cyclic redundancy check (CRC codes. While some research uses multiple CRC codes to reduce memory and time complexity, we consider the operational complexity of decoding, and reduce it by optimizing CRC positions in combination with a modified decoding operation. Resultingly, the proposed scheme obtains not only complexity reduction from early stopping of decoding, but also additional reduction from the reduced number of decoding paths.

Majorana fermion codes

International Nuclear Information System (INIS)

Bravyi, Sergey; Terhal, Barbara M; Leemhuis, Bernhard

2010-01-01

We initiate the study of Majorana fermion codes (MFCs). These codes can be viewed as extensions of Kitaev's one-dimensional (1D) model of unpaired Majorana fermions in quantum wires to higher spatial dimensions and interacting fermions. The purpose of MFCs is to protect quantum information against low-weight fermionic errors, that is, operators acting on sufficiently small subsets of fermionic modes. We examine to what extent MFCs can surpass qubit stabilizer codes in terms of their stability properties. A general construction of 2D MFCs is proposed that combines topological protection based on a macroscopic code distance with protection based on fermionic parity conservation. Finally, we use MFCs to show how to transform any qubit stabilizer code to a weakly self-dual CSS code.

DISP1 code

International Nuclear Information System (INIS)

Vokac, P.

1999-12-01

DISP1 code is a simple tool for assessment of the dispersion of the fission product cloud escaping from a nuclear power plant after an accident. The code makes it possible to tentatively check the feasibility of calculations by more complex PSA3 codes and/or codes for real-time dispersion calculations. The number of input parameters is reasonably low and the user interface is simple enough to allow a rapid processing of sensitivity analyses. All input data entered through the user interface are stored in the text format. Implementation of dispersion model corrections taken from the ARCON96 code enables the DISP1 code to be employed for assessment of the radiation hazard within the NPP area, in the control room for instance. (P.A.)

Fundamentals of convolutional coding

CERN Document Server

Johannesson, Rolf

2015-01-01

Fundamentals of Convolutional Coding, Second Edition, regarded as a bible of convolutional coding brings you a clear and comprehensive discussion of the basic principles of this field * Two new chapters on low-density parity-check (LDPC) convolutional codes and iterative coding * Viterbi, BCJR, BEAST, list, and sequential decoding of convolutional codes * Distance properties of convolutional codes * Includes a downloadable solutions manual

Trust, Personal Moral Codes, and the Resource-Advantage Theory of Competition: Explaining Productivity, Economic Growth, and Wealth Creation

Directory of Open Access Journals (Sweden)

Shelby D. Hunt

2012-06-01

Full Text Available Scholars agree that societal-level moral codes that promote social trust also promote wealth creation.  However, what specific kinds of societal-level moral codes promote social trust?  Also, by what specific kind of competitive process does social trust promote wealth creation?  Because societal-level moral codes are composed of or formed from peoples’ personal moral codes, this article explores a theory of ethics, known as the “Hunt-Vitell” theory of ethics, that illuminates the concept of personal moral codes and uses the theory to discuss which types of personal moral codes foster trust and distrust in society.  This article then uses resource-advantage (R-A theory, one of the most completely articulated dynamic theories of competition, to show the process by which trust-promoting, societal-level moral codes promote productivity and economic growth.  That is, they promote wealth creation.

ARTEMIS: The core simulator of AREVA NP's next generation coupled neutronics/thermal-hydraulics code system ARCADIAR

International Nuclear Information System (INIS)

Hobson, Greg; Merk, Stephan; Bolloni, Hans-Wilhelm; Breith, Karl-Albert; Curca-Tivig, Florin; Van Geemert, Rene; Heinecke, Jochen; Hartmann, Bettina; Porsch, Dieter; Tiles, Viatcheslav; Dall'Osso, Aldo; Pothet, Baptiste

2008-01-01

AREVA NP has developed a next-generation coupled neutronics/thermal-hydraulics code system, ARCADIA R , to fulfil customer's current demands and even anticipate their future demands in terms of accuracy and performance. The new code system will be implemented world-wide and will replace several code systems currently used in various global regions. An extensive phase of verification and validation of the new code system is currently in progress. One of the principal components of this new system is the core simulator, ARTEMIS. Besides the stand-alone tests on the individual computational modules, integrated tests on the overall code are being performed in order to check for non-regression as well as for verification of the code. Several benchmark problems have been successfully calculated. Full-core depletion cycles of different plant types from AREVA's French, American and German regions (e.g. N4 and KONVOI types) have been performed with ARTEMIS (using APOLLO2-A cross sections) and compared directly with current production codes, e.g. with SCIENCE and CASCADE-3D, and additionally with measurements. (authors)

78 FR 18321 - International Code Council: The Update Process for the International Codes and Standards

Science.gov (United States)

2013-03-26

... Energy Conservation Code. International Existing Building Code. International Fire Code. International... Code. International Property Maintenance Code. International Residential Code. International Swimming Pool and Spa Code International Wildland-Urban Interface Code. International Zoning Code. ICC Standards...

Two-terminal video coding.

Science.gov (United States)

Yang, Yang; Stanković, Vladimir; Xiong, Zixiang; Zhao, Wei

2009-03-01

Following recent works on the rate region of the quadratic Gaussian two-terminal source coding problem and limit-approaching code designs, this paper examines multiterminal source coding of two correlated, i.e., stereo, video sequences to save the sum rate over independent coding of both sequences. Two multiterminal video coding schemes are proposed. In the first scheme, the left sequence of the stereo pair is coded by H.264/AVC and used at the joint decoder to facilitate Wyner-Ziv coding of the right video sequence. The first I-frame of the right sequence is successively coded by H.264/AVC Intracoding and Wyner-Ziv coding. An efficient stereo matching algorithm based on loopy belief propagation is then adopted at the decoder to produce pixel-level disparity maps between the corresponding frames of the two decoded video sequences on the fly. Based on the disparity maps, side information for both motion vectors and motion-compensated residual frames of the right sequence are generated at the decoder before Wyner-Ziv encoding. In the second scheme, source splitting is employed on top of classic and Wyner-Ziv coding for compression of both I-frames to allow flexible rate allocation between the two sequences. Experiments with both schemes on stereo video sequences using H.264/AVC, LDPC codes for Slepian-Wolf coding of the motion vectors, and scalar quantization in conjunction with LDPC codes for Wyner-Ziv coding of the residual coefficients give a slightly lower sum rate than separate H.264/AVC coding of both sequences at the same video quality.

The network code

International Nuclear Information System (INIS)

1997-01-01

The Network Code defines the rights and responsibilities of all users of the natural gas transportation system in the liberalised gas industry in the United Kingdom. This report describes the operation of the Code, what it means, how it works and its implications for the various participants in the industry. The topics covered are: development of the competitive gas market in the UK; key points in the Code; gas transportation charging; impact of the Code on producers upstream; impact on shippers; gas storage; supply point administration; impact of the Code on end users; the future. (20 tables; 33 figures) (UK)

XSOR codes users manual

International Nuclear Information System (INIS)

Jow, Hong-Nian; Murfin, W.B.; Johnson, J.D.

1993-11-01

This report describes the source term estimation codes, XSORs. The codes are written for three pressurized water reactors (Surry, Sequoyah, and Zion) and two boiling water reactors (Peach Bottom and Grand Gulf). The ensemble of codes has been named ''XSOR''. The purpose of XSOR codes is to estimate the source terms which would be released to the atmosphere in severe accidents. A source term includes the release fractions of several radionuclide groups, the timing and duration of releases, the rates of energy release, and the elevation of releases. The codes have been developed by Sandia National Laboratories for the US Nuclear Regulatory Commission (NRC) in support of the NUREG-1150 program. The XSOR codes are fast running parametric codes and are used as surrogates for detailed mechanistic codes. The XSOR codes also provide the capability to explore the phenomena and their uncertainty which are not currently modeled by the mechanistic codes. The uncertainty distributions of input parameters may be used by an. XSOR code to estimate the uncertainty of source terms

Rate-adaptive BCH coding for Slepian-Wolf coding of highly correlated sources

DEFF Research Database (Denmark)

Forchhammer, Søren; Salmistraro, Matteo; Larsen, Knud J.

2012-01-01

This paper considers using BCH codes for distributed source coding using feedback. The focus is on coding using short block lengths for a binary source, X, having a high correlation between each symbol to be coded and a side information, Y, such that the marginal probability of each symbol, Xi in X......, given Y is highly skewed. In the analysis, noiseless feedback and noiseless communication are assumed. A rate-adaptive BCH code is presented and applied to distributed source coding. Simulation results for a fixed error probability show that rate-adaptive BCH achieves better performance than LDPCA (Low......-Density Parity-Check Accumulate) codes for high correlation between source symbols and the side information....

Comparing weld inspection codes: radiography vs. ultrasonics

International Nuclear Information System (INIS)

Moles, M.; Ginzel, E.

2007-01-01

Requirements for weld quality are continually increasing. This is due to a combination of factors: increased public awareness; bigger legal penalties; improved and thinner steels; better analysis techniques such as Engineering Critical Assessment (ECA); higher material costs. Weld quality is primarily dictated by construction codes, which should reflect the needs of society and industry: safety, the environment, society, and cost-effectiveness. As R and D produces new products, techniques and procedures, ideally these developments should be reflected in the codes. While pressure vessel and structural welding are certainly included here, it is really pipeline weld inspections that are setting the pace on new developments. For pipelines, a major shift was made from radiography to ultrasonics in Alberta some decades ago. This was driven by the 'need for speed', plus the requirement to size defects in the vertical plane for ECA (also called Fracture Mechanics or Fitness-For-Purpose). One of the main objectives of ECA was to benefit from the calculated fracture toughness of materials, and not to rely on the overly conservative workmanship criteria in radiography. In practice, performing repairs on higher quality material often does more harm than good; changing the microstructure can seriously compromise the material properties. Rising steel costs are another major driving force, so higher strength, thinner materials are being used. Under these conditions, ECA and defect sizing are critical. This paper compares where the various North American codes for pipelines, pressure vessels and structural welds stand on using advanced inspection techniques: ultrasonics, phased arrays, ECA, sizing techniques. For those codes which are not using the latest technologies, there are typical routes for incorporating them. (author)

MiR-495 and miR-218 regulate the expression of the Onecut transcription factors HNF-6 and OC-2

Energy Technology Data Exchange (ETDEWEB)

Simion, Alexandru; Laudadio, Ilaria; Prevot, Pierre-Paul; Raynaud, Peggy; Lemaigre, Frederic P. [Universite catholique de Louvain, de Duve Institute, 75 Avenue Hippocrate 7529, B-1200 Brussels (Belgium); Jacquemin, Patrick, E-mail: patrick.jacquemin@uclouvain.be [Universite catholique de Louvain, de Duve Institute, 75 Avenue Hippocrate 7529, B-1200 Brussels (Belgium)

2010-01-01

MicroRNAs are small, non-coding RNAs that posttranscriptionally regulate gene expression mainly by binding to the 3'UTR of their target mRNAs. Recent data revealed that microRNAs have an important role in pancreas and liver development and physiology. Using cloning and microarray profiling approaches, we show that a unique repertoire of microRNAs is expressed at the onset of liver and pancreas organogenesis, and in pancreas and liver at key stages of cell fate determination. Among the microRNAs that are expressed at these stages, miR-495 and miR-218 were predicted to, respectively, target the Onecut (OC) transcription factors Hepatocyte Nuclear Factor-6 (HNF-6/OC-1) and OC-2, two important regulators of liver and pancreas development. MiR-495 and miR-218 are dynamically expressed in developing liver and pancreas, and by transient transfection, we show that they target HNF-6 and OC-2 3'UTRs. Moreover, when overexpressed in cultured cells, miR-495 and miR-218 decrease the endogenous levels of HNF-6 and OC-2 mRNA. These results indicate that the expression of regulators of liver and pancreas development is modulated by microRNAs. They also suggest a developmental role for miR-495 and miR-218.

MiR-495 and miR-218 regulate the expression of the Onecut transcription factors HNF-6 and OC-2

International Nuclear Information System (INIS)

Simion, Alexandru; Laudadio, Ilaria; Prevot, Pierre-Paul; Raynaud, Peggy; Lemaigre, Frederic P.; Jacquemin, Patrick

2010-01-01

MicroRNAs are small, non-coding RNAs that posttranscriptionally regulate gene expression mainly by binding to the 3'UTR of their target mRNAs. Recent data revealed that microRNAs have an important role in pancreas and liver development and physiology. Using cloning and microarray profiling approaches, we show that a unique repertoire of microRNAs is expressed at the onset of liver and pancreas organogenesis, and in pancreas and liver at key stages of cell fate determination. Among the microRNAs that are expressed at these stages, miR-495 and miR-218 were predicted to, respectively, target the Onecut (OC) transcription factors Hepatocyte Nuclear Factor-6 (HNF-6/OC-1) and OC-2, two important regulators of liver and pancreas development. MiR-495 and miR-218 are dynamically expressed in developing liver and pancreas, and by transient transfection, we show that they target HNF-6 and OC-2 3'UTRs. Moreover, when overexpressed in cultured cells, miR-495 and miR-218 decrease the endogenous levels of HNF-6 and OC-2 mRNA. These results indicate that the expression of regulators of liver and pancreas development is modulated by microRNAs. They also suggest a developmental role for miR-495 and miR-218.

Coding in Muscle Disease.

Science.gov (United States)

Jones, Lyell K; Ney, John P

2016-12-01

Accurate coding is critically important for clinical practice and research. Ongoing changes to diagnostic and billing codes require the clinician to stay abreast of coding updates. Payment for health care services, data sets for health services research, and reporting for medical quality improvement all require accurate administrative coding. This article provides an overview of administrative coding for patients with muscle disease and includes a case-based review of diagnostic and Evaluation and Management (E/M) coding principles in patients with myopathy. Procedural coding for electrodiagnostic studies and neuromuscular ultrasound is also reviewed.

Generalized concatenated quantum codes

International Nuclear Information System (INIS)

Grassl, Markus; Shor, Peter; Smith, Graeme; Smolin, John; Zeng Bei

2009-01-01

We discuss the concept of generalized concatenated quantum codes. This generalized concatenation method provides a systematical way for constructing good quantum codes, both stabilizer codes and nonadditive codes. Using this method, we construct families of single-error-correcting nonadditive quantum codes, in both binary and nonbinary cases, which not only outperform any stabilizer codes for finite block length but also asymptotically meet the quantum Hamming bound for large block length.

Synthesizing Certified Code

OpenAIRE

Whalen, Michael; Schumann, Johann; Fischer, Bernd

2002-01-01

Code certification is a lightweight approach for formally demonstrating software quality. Its basic idea is to require code producers to provide formal proofs that their code satisfies certain quality properties. These proofs serve as certificates that can be checked independently. Since code certification uses the same underlying technology as program verification, it requires detailed annotations (e.g., loop invariants) to make the proofs possible. However, manually adding annotations to th...

Coding Labour

Directory of Open Access Journals (Sweden)

Anthony McCosker

2014-03-01

Full Text Available As well as introducing the Coding Labour section, the authors explore the diffusion of code across the material contexts of everyday life, through the objects and tools of mediation, the systems and practices of cultural production and organisational management, and in the material conditions of labour. Taking code beyond computation and software, their specific focus is on the increasingly familiar connections between code and labour with a focus on the codification and modulation of affect through technologies and practices of management within the contemporary work organisation. In the grey literature of spreadsheets, minutes, workload models, email and the like they identify a violence of forms through which workplace affect, in its constant flux of crisis and ‘prodromal’ modes, is regulated and governed.

Updating rDNA restriction enzyme maps of Tetrahymena reveals four new intron-containing species

DEFF Research Database (Denmark)

Nielsen, Henrik; Simon, E M; Engberg, J

1985-01-01

an intron in the 26s rRNA coding region. The evolutionary relationship among the species of the T. pyriformis complex was examined on the basis of the rDNA maps with emphasis on similarities between two of the new species and the widely studied T. thermophila and T. pigmentosa. Examination of a large number...

Interface requirements to couple thermal-hydraulic codes to 3D neutronic codes

Energy Technology Data Exchange (ETDEWEB)

Langenbuch, S.; Austregesilo, H.; Velkov, K. [GRS, Garching (Germany)] [and others

1997-07-01

The present situation of thermalhydraulics codes and 3D neutronics codes is briefly described and general considerations for coupling of these codes are discussed. Two different basic approaches of coupling are identified and their relative advantages and disadvantages are discussed. The implementation of the coupling for 3D neutronics codes in the system ATHLET is presented. Meanwhile, this interface is used for coupling three different 3D neutronics codes.

Interface requirements to couple thermal-hydraulic codes to 3D neutronic codes

International Nuclear Information System (INIS)

Langenbuch, S.; Austregesilo, H.; Velkov, K.

1997-01-01

The present situation of thermalhydraulics codes and 3D neutronics codes is briefly described and general considerations for coupling of these codes are discussed. Two different basic approaches of coupling are identified and their relative advantages and disadvantages are discussed. The implementation of the coupling for 3D neutronics codes in the system ATHLET is presented. Meanwhile, this interface is used for coupling three different 3D neutronics codes

Synthesizing Certified Code

Science.gov (United States)

Whalen, Michael; Schumann, Johann; Fischer, Bernd

2002-01-01

Code certification is a lightweight approach to demonstrate software quality on a formal level. Its basic idea is to require producers to provide formal proofs that their code satisfies certain quality properties. These proofs serve as certificates which can be checked independently. Since code certification uses the same underlying technology as program verification, it also requires many detailed annotations (e.g., loop invariants) to make the proofs possible. However, manually adding theses annotations to the code is time-consuming and error-prone. We address this problem by combining code certification with automatic program synthesis. We propose an approach to generate simultaneously, from a high-level specification, code and all annotations required to certify generated code. Here, we describe a certification extension of AUTOBAYES, a synthesis tool which automatically generates complex data analysis programs from compact specifications. AUTOBAYES contains sufficient high-level domain knowledge to generate detailed annotations. This allows us to use a general-purpose verification condition generator to produce a set of proof obligations in first-order logic. The obligations are then discharged using the automated theorem E-SETHEO. We demonstrate our approach by certifying operator safety for a generated iterative data classification program without manual annotation of the code.

Large Scale Earth's Bow Shock with Northern IMF as Simulated by PIC Code in Parallel with MHD Model

Science.gov (United States)

Baraka, Suleiman

2016-06-01

In this paper, we propose a 3D kinetic model (particle-in-cell, PIC) for the description of the large scale Earth's bow shock. The proposed version is stable and does not require huge or extensive computer resources. Because PIC simulations work with scaled plasma and field parameters, we also propose to validate our code by comparing its results with the available MHD simulations under same scaled solar wind (SW) and (IMF) conditions. We report new results from the two models. In both codes the Earth's bow shock position is found to be ≈14.8 R E along the Sun-Earth line, and ≈29 R E on the dusk side. Those findings are consistent with past in situ observations. Both simulations reproduce the theoretical jump conditions at the shock. However, the PIC code density and temperature distributions are inflated and slightly shifted sunward when compared to the MHD results. Kinetic electron motions and reflected ions upstream may cause this sunward shift. Species distributions in the foreshock region are depicted within the transition of the shock (measured ≈2 c/ ω pi for Θ Bn = 90° and M MS = 4.7) and in the downstream. The size of the foot jump in the magnetic field at the shock is measured to be (1.7 c/ ω pi ). In the foreshocked region, the thermal velocity is found equal to 213 km s-1 at 15 R E and is equal to 63 km s -1 at 12 R E (magnetosheath region). Despite the large cell size of the current version of the PIC code, it is powerful to retain macrostructure of planets magnetospheres in very short time, thus it can be used for pedagogical test purposes. It is also likely complementary with MHD to deepen our understanding of the large scale magnetosphere.

Report number codes

Energy Technology Data Exchange (ETDEWEB)

Nelson, R.N. (ed.)

1985-05-01

This publication lists all report number codes processed by the Office of Scientific and Technical Information. The report codes are substantially based on the American National Standards Institute, Standard Technical Report Number (STRN)-Format and Creation Z39.23-1983. The Standard Technical Report Number (STRN) provides one of the primary methods of identifying a specific technical report. The STRN consists of two parts: The report code and the sequential number. The report code identifies the issuing organization, a specific program, or a type of document. The sequential number, which is assigned in sequence by each report issuing entity, is not included in this publication. Part I of this compilation is alphabetized by report codes followed by issuing installations. Part II lists the issuing organization followed by the assigned report code(s). In both Parts I and II, the names of issuing organizations appear for the most part in the form used at the time the reports were issued. However, for some of the more prolific installations which have had name changes, all entries have been merged under the current name.

Report number codes

International Nuclear Information System (INIS)

Nelson, R.N.

1985-05-01

This publication lists all report number codes processed by the Office of Scientific and Technical Information. The report codes are substantially based on the American National Standards Institute, Standard Technical Report Number (STRN)-Format and Creation Z39.23-1983. The Standard Technical Report Number (STRN) provides one of the primary methods of identifying a specific technical report. The STRN consists of two parts: The report code and the sequential number. The report code identifies the issuing organization, a specific program, or a type of document. The sequential number, which is assigned in sequence by each report issuing entity, is not included in this publication. Part I of this compilation is alphabetized by report codes followed by issuing installations. Part II lists the issuing organization followed by the assigned report code(s). In both Parts I and II, the names of issuing organizations appear for the most part in the form used at the time the reports were issued. However, for some of the more prolific installations which have had name changes, all entries have been merged under the current name

The computer code Eurdyn - 1 M. (Release 1) Part 2: User's Manual

International Nuclear Information System (INIS)

Donea, J.; Giuliani, S.

1979-01-01

This report is the user's manual for the computer code Eurdyn-1 M developed at the J.R.C. Ispra for use in containment and fuel subassembly analyses for fast reactor safety studies. The input data are defined and a test problem is presented to illustrate both the input and the output of results

Confidence building on the total system performance assessment code, MASCOT-K for permanent disposal of HLW in Korea

Energy Technology Data Exchange (ETDEWEB)

Hwang, Y. S.; Kim, S. G.; Kang, C. H

2002-12-01

To perform Total System Performance Assessment(TSPA) of a potential HLW repository, it is necessary to develop the TSPA code. KAERI has developed the one-dimensional PSA code MASCOT-K since 1997 and verified special modules dedicated for the dissolution of spent nuclear fuel. In the second R and D phase, MASCOT-K is once again verified as a part of the confidence building for TSPA. The AMBER code based on the totally different mathematical approach, compartment theory is used together with MASCOT-K to assess the annual individual doses for given K- and Q- scenarios. Results indicate that both AMBER and MASCOT-K simulate the annual individual doses to a potential biosphere. And the MASCOT-K is more flexible to describe the natural barrier such as a fracture for sensitivity studies. In the third R and D phase, MASCOT-K will be actively used to check whether the proposed KAERI reference disposal concept is solid or not.

Confidence building on the total system performance assessment code, MASCOT-K for permanent disposal of HLW in Korea

International Nuclear Information System (INIS)

Hwang, Y. S.; Kim, S. G.; Kang, C. H.

2002-12-01

To perform Total System Performance Assessment(TSPA) of a potential HLW repository, it is necessary to develop the TSPA code. KAERI has developed the one-dimensional PSA code MASCOT-K since 1997 and verified special modules dedicated for the dissolution of spent nuclear fuel. In the second R and D phase, MASCOT-K is once again verified as a part of the confidence building for TSPA. The AMBER code based on the totally different mathematical approach, compartment theory is used together with MASCOT-K to assess the annual individual doses for given K- and Q- scenarios. Results indicate that both AMBER and MASCOT-K simulate the annual individual doses to a potential biosphere. And the MASCOT-K is more flexible to describe the natural barrier such as a fracture for sensitivity studies. In the third R and D phase, MASCOT-K will be actively used to check whether the proposed KAERI reference disposal concept is solid or not

Performance Analysis of CRC Codes for Systematic and Nonsystematic Polar Codes with List Decoding

Directory of Open Access Journals (Sweden)

Takumi Murata

2018-01-01

Full Text Available Successive cancellation list (SCL decoding of polar codes is an effective approach that can significantly outperform the original successive cancellation (SC decoding, provided that proper cyclic redundancy-check (CRC codes are employed at the stage of candidate selection. Previous studies on CRC-assisted polar codes mostly focus on improvement of the decoding algorithms as well as their implementation, and little attention has been paid to the CRC code structure itself. For the CRC-concatenated polar codes with CRC code as their outer code, the use of longer CRC code leads to reduction of information rate, whereas the use of shorter CRC code may reduce the error detection probability, thus degrading the frame error rate (FER performance. Therefore, CRC codes of proper length should be employed in order to optimize the FER performance for a given signal-to-noise ratio (SNR per information bit. In this paper, we investigate the effect of CRC codes on the FER performance of polar codes with list decoding in terms of the CRC code length as well as its generator polynomials. Both the original nonsystematic and systematic polar codes are considered, and we also demonstrate that different behaviors of CRC codes should be observed depending on whether the inner polar code is systematic or not.

Sociolinguistic aspects of language change in kabiye-french code ...

African Journals Online (AJOL)

Ce phénomène peut s'expliquer par le fait que la réussite à l'école, et par conséquent dans la vie sociale, dépend de la maîtrise du Français. La présente étude montre qu'aujourd'hui, le 'code-switching' kabiyè et français est devenu le moyen de communication le plus courant non seulement entre les scolarisés, mais ...

p53 Represses the Oncogenic Sno-MiR-28 Derived from a SnoRNA.

Directory of Open Access Journals (Sweden)

Feng Yu

Full Text Available p53 is a master tumour repressor that participates in vast regulatory networks, including feedback loops involving microRNAs (miRNAs that regulate p53 and that themselves are direct p53 transcriptional targets. We show here that a group of polycistronic miRNA-like non-coding RNAs derived from small nucleolar RNAs (sno-miRNAs are transcriptionally repressed by p53 through their host gene, SNHG1. The most abundant of these, sno-miR-28, directly targets the p53-stabilizing gene, TAF9B. Collectively, p53, SNHG1, sno-miR-28 and TAF9B form a regulatory loop which affects p53 stability and downstream p53-regulated pathways. In addition, SNHG1, SNORD28 and sno-miR-28 are all significantly upregulated in breast tumours and the overexpression of sno-miR-28 promotes breast epithelial cell proliferation. This research has broadened our knowledge of the crosstalk between small non-coding RNA pathways and roles of sno-miRNAs in p53 regulation.

ERROR-CONTROL CODING OF ADS-B MESSAGES FOR IRIDIUM SATELLITES

Directory of Open Access Journals (Sweden)

Volodymyr Kharchenko

2013-12-01

Full Text Available For modelling of ADS-B messages transmitting on the base of low-orbit satellite constellation Іrіdіum the model of a communication channel “Aircraft - Satellite - Ground Station” was built using MATLAB Sіmulіnk. This model allowed to investigate dependences of the Bit Error Rate on a type of  signal coding/decoding, ratio Eb/N0 and satellite repeater gain

Methods for the development of large computer codes under LTSS

International Nuclear Information System (INIS)

Sicilian, J.M.

1977-06-01

TRAC is a large computer code being developed by Group Q-6 for the analysis of the transient thermal hydraulic behavior of light-water nuclear reactors. A system designed to assist the development of TRAC is described. The system consists of a central HYDRA dataset, R6LIB, containing files used in the development of TRAC, and a file maintenance program, HORSE, which facilitates the use of this dataset

Technical basis for the extension of ASME Code Case N-494 for assessment of austenitic piping

International Nuclear Information System (INIS)

Bloom, J.M.

1995-01-01

In 1990, the ASME Boiler and Pressure Vessel Code for Nuclear Components approved Code Case N-494 as an alternative procedure for evaluating laws in Light Water Reactor alterative procedure for evaluating flaws in Light Water Reactor (LWR) ferritic piping. The approach is an alternative to Appendix H of the ASME Code and alloys the user to remove some unnecessary conservatism in the existing procedure by allowing the use of pipe specific material properties. The Code Case is an implementation of the methodology of the Deformation Plasticity Failure Assessment diagram (DPFAD). The key ingredient in the application of DPFAD is that the material stress-strain curve must be in the format of a simple power law hardening stress-strain curve such as the Ramberg-Osgood (R-O) model. Ferritic materials can be accurately fit by the R-O model and, therefore, it was natural to use the DPFAD methodology for the assessment of LWR ferritic piping. An extension of Code Case N-494 to austenitic piping required a modification of the existing DPFAD methodology. The Code Case N-494 approach was revised using the PWFAD procedure in the same manner as in the development of the original N-494 approach for ferritic materials. A lower bound stress-strain curve was used to generate a PWFAD curve for the geometry of a part-through wall circumferential flaw in a cylinder under tension. Earlier work demonstrated that a cylinder under axial tension with a 50% flaw depth, 90 degrees in circumference, and radius to thickness of 10, produced a lower bound FAD curve. Validation of the new proposed Code Case procedure for austenitic piping was performed using actual pipe test data. Using the lower bound PWFAD curve, pipe test results were conservatively predicted. The resultant development of ht PWFAD curve for austenitic piping led to a revision of Code Case N-494 to include a procedure for assessment of flaws in austenitic piping

MCMCpack: Markov Chain Monte Carlo in R

Directory of Open Access Journals (Sweden)

Andrew D. Martin

2011-08-01

Full Text Available We introduce MCMCpack, an R package that contains functions to perform Bayesian inference using posterior simulation for a number of statistical models. In addition to code that can be used to fit commonly used models, MCMCpack also contains some useful utility functions, including some additional density functions and pseudo-random number generators for statistical distributions, a general purpose Metropolis sampling algorithm, and tools for visualization.

Strict optical orthogonal codes for purely asynchronous code-division multiple-access applications

Science.gov (United States)

Zhang, Jian-Guo

1996-12-01

Strict optical orthogonal codes are presented for purely asynchronous optical code-division multiple-access (CDMA) applications. The proposed code can strictly guarantee the peaks of its cross-correlation functions and the sidelobes of any of its autocorrelation functions to have a value of 1 in purely asynchronous data communications. The basic theory of the proposed codes is given. An experiment on optical CDMA systems is also demonstrated to verify the characteristics of the proposed code.

Entropy Coding in HEVC

OpenAIRE

Sze, Vivienne; Marpe, Detlev

2014-01-01

Context-Based Adaptive Binary Arithmetic Coding (CABAC) is a method of entropy coding first introduced in H.264/AVC and now used in the latest High Efficiency Video Coding (HEVC) standard. While it provides high coding efficiency, the data dependencies in H.264/AVC CABAC make it challenging to parallelize and thus limit its throughput. Accordingly, during the standardization of entropy coding for HEVC, both aspects of coding efficiency and throughput were considered. This chapter describes th...

Quantum Codes From Negacyclic Codes over Group Ring ( Fq + υFq) G

International Nuclear Information System (INIS)

Koroglu, Mehmet E.; Siap, Irfan

2016-01-01

In this paper, we determine self dual and self orthogonal codes arising from negacyclic codes over the group ring ( F q + υF q ) G . By taking a suitable Gray image of these codes we obtain many good parameter quantum error-correcting codes over F q . (paper)

CFD simulation of IPR-R1 Triga subchannels fluid flow

International Nuclear Information System (INIS)

Silva, Vitor V.; Santos, A.; Mesquita, Amir Z.; Silva, P.S. da; Pereira, C.

2013-01-01

Computational fluid dynamics (CFD) codes have been extensively used in engineering problems, with increasing use in nuclear engineering. One of these computer codes is OpenFOAM. It is freely distributed with source code and offers a great flexibility in simulating particular conditions like those found in many problems in nuclear reactor analysis. The aim of this work is to simulate fluid flow and heat flux in three different configurations of subchannels of IPR-R1 TRIGA reactor using OpenFOAM. The data will be then validated against real experimental data obtained during the operation of the reactor at 100kW. This validation process is fundamental to allow the use of the software and associated model to simulate reactor's operation at different conditions, namely different power e fluid flow velocities. (author)

CFD simulation of IPR-R1 Triga subchannels fluid flow

Energy Technology Data Exchange (ETDEWEB)

Silva, Vitor V.; Santos, A.; Mesquita, Amir Z.; Silva, P.S. da, E-mail: vitors@cdtn.br, E-mail: aacs@cdtn.br, E-mail: amir@cdtn.br, E-mail: psblsg@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN - MG), Belo Horizonte, MG (Brazil); Pereira, C., E-mail: claubia@nuclear.ufmg.br [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Dept. de Engenharia Nuclear

2013-07-01

Computational fluid dynamics (CFD) codes have been extensively used in engineering problems, with increasing use in nuclear engineering. One of these computer codes is OpenFOAM. It is freely distributed with source code and offers a great flexibility in simulating particular conditions like those found in many problems in nuclear reactor analysis. The aim of this work is to simulate fluid flow and heat flux in three different configurations of subchannels of IPR-R1 TRIGA reactor using OpenFOAM. The data will be then validated against real experimental data obtained during the operation of the reactor at 100kW. This validation process is fundamental to allow the use of the software and associated model to simulate reactor's operation at different conditions, namely different power e fluid flow velocities. (author)

Trellis and turbo coding iterative and graph-based error control coding

CERN Document Server

Schlegel, Christian B

2015-01-01

This new edition has been extensively revised to reflect the progress in error control coding over the past few years. Over 60% of the material has been completely reworked, and 30% of the material is original. Convolutional, turbo, and low density parity-check (LDPC) coding and polar codes in a unified framework. Advanced research-related developments such as spatial coupling. A focus on algorithmic and implementation aspects of error control coding.

Syndrome-source-coding and its universal generalization. [error correcting codes for data compression

Science.gov (United States)

Ancheta, T. C., Jr.

1976-01-01

A method of using error-correcting codes to obtain data compression, called syndrome-source-coding, is described in which the source sequence is treated as an error pattern whose syndrome forms the compressed data. It is shown that syndrome-source-coding can achieve arbitrarily small distortion with the number of compressed digits per source digit arbitrarily close to the entropy of a binary memoryless source. A 'universal' generalization of syndrome-source-coding is formulated which provides robustly effective distortionless coding of source ensembles. Two examples are given, comparing the performance of noiseless universal syndrome-source-coding to (1) run-length coding and (2) Lynch-Davisson-Schalkwijk-Cover universal coding for an ensemble of binary memoryless sources.

The use of best estimate codes to improve the simulation in real time

International Nuclear Information System (INIS)

Rivero, N.; Esteban, J. A.; Lenhardt, G.

2007-01-01

Best estimate codes are assumed to be the technology solution providing the most realistic and accurate response. Best estimate technology provides a complementary solution to the conservative simulation technology usually applied to determine plant safety margins and perform security related studies. Tecnatom in the early 90's, within the MAS project, pioneered the initiative to implement best estimate code in its training simulators. Result of this project was the implementation of the first six-equations thermal hydraulic code worldwide (TRAC R T), running in a training environment. To meet real time and other specific training requirements, it was necessary to overcome important difficulties. Tecnatom has just adapted the Global Nuclear Fuel core Design code: PANAC 11, and is about to complete the General Electric TRACG04 thermal hydraulic code adaptation. This technology features a unique solution for nuclear plants aiming at providing the highest fidelity in simulation, enabling to consider the simulator as a multipurpose: engineering and training, simulation platform. Besides, a visual environment designed to optimize the models life cycle, covering both pre and post-processing activities, is in its late development phase. (Author)

Identifying small RNAs derived from maternal- and somatic-type rRNAs in zebrafish development.

Science.gov (United States)

Locati, Mauro D; Pagano, Johanna F B; Abdullah, Farah; Ensink, Wim A; van Olst, Marina; van Leeuwen, Selina; Nehrdich, Ulrike; Spaink, Herman P; Rauwerda, Han; Jonker, Martijs J; Dekker, Rob J; Breit, Timo M

2018-02-09

rRNAs are non-coding RNAs present in all prokaryotes and eukaryotes. In eukaryotes there are four rRNAs: 18S, 5.8S, 28S, originating from a common precursor (45S), and 5S. We have recently discovered the existence of two distinct developmental types of rRNA: a maternal-type, present in eggs and a somatic-type, expressed in adult tissues. Lately, next-generation sequencing has allowed the discovery of new small-RNAs deriving from longer non-coding RNAs, including small-RNAs from rRNAs (srRNAs). Here, we systemically investigated srRNAs of maternal- or somatic-type 18S, 5.8S, 28S, with small-RNAseq from many zebrafish developmental stages. We identified new srRNAs for each rRNA. For 5.8S, we found srRNA consisting of the 5' or 3' halves, with only the latter having different sequence for the maternal- and somatic-types. For 18S, we discovered 21 nt srRNA from the 5' end of the 18S rRNA with a striking resemblance to microRNAs; as it is likely processed from a stem-loop precursor and present in human and mouse Argonaute-complexed small-RNA. For 28S, an abundant 80 nt srRNA from the 3' end of the 28S rRNA was found. The expression levels during embryogenesis of these srRNA indicate they are not generated from rRNA degradation and might have a role in the zebrafish development.

ComboCoding: Combined intra-/inter-flow network coding for TCP over disruptive MANETs

Directory of Open Access Journals (Sweden)

Chien-Chia Chen

2011-07-01

Full Text Available TCP over wireless networks is challenging due to random losses and ACK interference. Although network coding schemes have been proposed to improve TCP robustness against extreme random losses, a critical problem still remains of DATA–ACK interference. To address this issue, we use inter-flow coding between DATA and ACK to reduce the number of transmissions among nodes. In addition, we also utilize a “pipeline” random linear coding scheme with adaptive redundancy to overcome high packet loss over unreliable links. The resulting coding scheme, ComboCoding, combines intra-flow and inter-flow coding to provide robust TCP transmission in disruptive wireless networks. The main contributions of our scheme are twofold; the efficient combination of random linear coding and XOR coding on bi-directional streams (DATA and ACK, and the novel redundancy control scheme that adapts to time-varying and space-varying link loss. The adaptive ComboCoding was tested on a variable hop string topology with unstable links and on a multipath MANET with dynamic topology. Simulation results show that TCP with ComboCoding delivers higher throughput than with other coding options in high loss and mobile scenarios, while introducing minimal overhead in normal operation.

Benchmarking Reactor Systems Studies by Comparison of EU and Japanese System Code Results for Different DEMO Concepts