WorldWideScience

Sample records for quiz gi snapshot

  1. Sleep Quiz

    Science.gov (United States)

    Skip Navigation Bar Home Current Issue Past Issues Sleep Quiz Past Issues / Summer 2007 Table of Contents ... on. Photo: iStock Take the National Center on Sleep Disorders Research Sleep Quiz TRUE OR FALSE ? _____1. ...

  2. Cholesterol IQ Quiz

    Science.gov (United States)

    ... Artery Disease Venous Thromboembolism Aortic Aneurysm More Cholesterol IQ Quiz Updated:Jul 5,2017 Begin the quiz ... What Your Cholesterol Levels Mean Common Misconceptions Cholesterol IQ Quiz • HDL, LDL, and Triglycerides • Causes of High ...

  3. Pet Allergy Quiz

    Science.gov (United States)

    ... Treatments ▸ Allergies ▸ Pet Allergy ▸ Pet Allergy Quiz Share | Pet Allergy Quiz More than half of U.S. households ... cat family. Yet, millions of people suffer from pet allergies. Take this quiz to test your knowledge ...

  4. Immune System Quiz

    Science.gov (United States)

    ... Safe Videos for Educators Search English Español Quiz: Immune System KidsHealth / For Kids / Quiz: Immune System Print How much do you know about your immune system? Find out by taking this quiz! About Us ...

  5. NeuroQuiz

    DEFF Research Database (Denmark)

    Brent, Mikkel Bo; Emmanuel, Thomas

    2016-01-01

    NeuroQuiz er en quiz-app udviklet til neuroanatomi. Den består af mere end 1500 spørgsmål og over 350 anatomiske billeder. Alle spørgsmål tager udgangspunkt i lærebogen Neuroanatomi af Carsten Reidies Bjarkam.......NeuroQuiz er en quiz-app udviklet til neuroanatomi. Den består af mere end 1500 spørgsmål og over 350 anatomiske billeder. Alle spørgsmål tager udgangspunkt i lærebogen Neuroanatomi af Carsten Reidies Bjarkam....

  6. Quiz: Water and Your Health

    Science.gov (United States)

    ... your health Quiz: Water and your health Quiz: Water and your health Clean water is an important part of being healthy. Do you know all of these fun facts about water? Take this quiz to find out! Then, test ...

  7. Quiz: Alzheimer's Disease

    Science.gov (United States)

    ... of this page please turn JavaScript on. Feature: Alzheimer's Disease Quiz: Alzheimer's Disease Past Issues / Winter 2015 Table of Contents ... How many Americans over age 65 may have Alzheimer's disease? as many as 5 million as many ...

  8. HistologiQuiz

    DEFF Research Database (Denmark)

    Brent, Mikkel Bo

    2015-01-01

    HistologiQuiz er en quiz-app udviklet til almen og speciel histologi. Den består af mere end 1400 spørgsmål og over 320 histologiske billeder. Alle spørgsmål tager udgangspunkt i lærebogen Genesers Histologi af Annemarie Brüel m.fl.......HistologiQuiz er en quiz-app udviklet til almen og speciel histologi. Den består af mere end 1400 spørgsmål og over 320 histologiske billeder. Alle spørgsmål tager udgangspunkt i lærebogen Genesers Histologi af Annemarie Brüel m.fl....

  9. Seashore marine table quiz

    OpenAIRE

    Institute, Marine

    2013-01-01

    Develop an increasing awareness of plants and animals that live in local marine environments including the seashore, seas and oceans of Ireland. After learning all about the seashore and other marine related lessons, this quiz can be used to evaluate the student’s knowledge of the marine related living things and natural environments. The table quiz can be used as a guide, highlighting facts about the marine environment and some of the animals that live there.

  10. Quiz om forkortelser

    DEFF Research Database (Denmark)

    Farø, Ken Joensen

    2012-01-01

    Bidraget er en quiz, som relaterer sig til en teoretisk artikel inde i tidsskriftet. Den illustrerer på pædagogisk vis de pointer, artiklen frembringer. Læserne skal gætte det etablerede basisudtryk bag 50 uetablerede, men relevante forkortelser. Den er vanskelig....

  11. Quiz gaming competitions for undergraduate medical students ...

    African Journals Online (AJOL)

    Quiz gaming competitions for undergraduate medical students: Questioning the MediQuiz. ... an audience Studies have shown that such quiz games promote active learning, and provide motivational impetus. ... AJOL African Journals Online.

  12. Adoga, GI

    African Journals Online (AJOL)

    Adoga, GI. Vol 3 (2001) - Articles Fluorometric Assessment Of Lysosomal Enzymes In Garlic Oil Treated Diabetic Rats Abstract. ISSN: 9783-1230. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

  13. SnapShot: Hormones of the gastrointestinal tract.

    Science.gov (United States)

    Coate, Katie C; Kliewer, Steven A; Mangelsdorf, David J

    2014-12-04

    Specialized endocrine cells secrete a variety of peptide hormones all along the gastrointestinal (GI) tract, making it one of the largest endocrine organs in the body. Nutrients and developmental and neural cues trigger the secretion of gastrointestinal (GI) hormones from specialized endocrine cells along the GI tract. These hormones act in target tissues to facilitate digestion and regulate energy homeostasis. This SnapShot summarizes the production and functions of GI hormones. Copyright © 2014 Elsevier Inc. All rights reserved.

  14. Quiz: Test Your Skin Cancer IQ

    Science.gov (United States)

    ... Feature: Skin Cancer Quiz: Test Your Skin Cancer IQ Past Issues / Summer 2013 Table of Contents 1. ... Sun – Safety First / Quiz: Test Your Skin Cancer IQ Summer 2013 Issue: Volume 8 Number 2 Page ...

  15. Headaches and Migraines: Migraine 101 Quiz

    Science.gov (United States)

    ... Bar Home Current Issue Past Issues Headaches and Migraines Migraine 101 Quiz Past Issues / Spring 2009 Table of ... the facts when it comes to headaches and migraines? Test your knowledge with this quick quiz. True/ ...

  16. Quiz: Alzheimer's Disease Quiz | Alzheimer's disease | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... of this page please turn Javascript on. Feature: Alzheimer's Disease Quiz: Alzheimer's Disease Quiz Past Issues / Fall 2010 Table of ... How many people in the United States have Alzheimer's disease? as many as 5.1 million as ...

  17. How's Your Self-Esteem? (Quiz)

    Science.gov (United States)

    ... topic for: Teens How Can I Improve My Self-Esteem? Rejection: How Well Do You Cope? (Quiz) How Can I Stop Focusing on My Flaws? Emotional Intelligence View more Partner Message About Us Contact Us ...

  18. SAFER - Company Snapshot - SAFER - Company Snapshot

    Data.gov (United States)

    Department of Transportation — The Company Snapshot is a concise electronic record of company identification, size, commodity information, and safety record, including the safety rating (if any),...

  19. Upper Gastrointestinal (GI) Series

    Science.gov (United States)

    ... standard barium upper GI series, which uses only barium a double-contrast upper GI series, which uses both air and ... evenly coat your upper GI tract with the barium. If you are having a double-contrast study, you will swallow gas-forming crystals that ...

  20. Nicotine Withdrawal; Measure Your Symptoms (Quiz)

    Science.gov (United States)

    ... to Quit Why Do You Want to Quit? Health Effects Benefits of Quitting How Much Will You Save How Smoking Affects Your Workout Secondhand Smoke Quiz: How Bad is Secondhand Smoke? E-Cigs, Menthol & Dip What We Know About E-Cigarettes Know More About Menthol Cigarettes Quitting Dip Stay ...

  1. SAFER - Company Snapshot

    Data.gov (United States)

    Department of Transportation — The Company Snapshot is a concise electronic record of company identification, size, commodity information, and safety record, including the safety rating (if any),...

  2. Instant Moodle quiz module how-to

    CERN Document Server

    Coy, Joan

    2013-01-01

    Step-by step application of the features of Moodle Quiz provides a good grounding in creating effective assessment FOR and OF learning. If you are doing any kind of instruction using Moodle as your Learning Management System, this book is for you! Strong assessment is one of the keys to effective instruction and successful learners. Readers are expected to have a basic working knowledge of Moodle and access to a course they are instructing.

  3. Upper GI Bleeding in Children

    Science.gov (United States)

    Upper GI Bleeding in Children What is upper GI Bleeding? Irritation and ulcers of the lining of the esophagus, stomach or duodenum can result in upper GI bleeding. When this occurs the child may vomit blood ...

  4. GI bleeding - slideshow

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/presentations/100162.htm GI bleeding - series—Normal anatomy To use the sharing features ... M. Editorial team. Related MedlinePlus Health Topics Gastrointestinal Bleeding A.D.A.M., Inc. is accredited by ...

  5. Performance SNAPSHOT Reports

    Data.gov (United States)

    Department of Housing and Urban Development — The HOME Program Performance SNAPSHOTs are quarterly cumulative performance reports, which can be useful in tracking the HOME program progress of participating...

  6. The Monte Carlo Quiz: Encouraging Punctual Completion and Deep Processing of Assigned Readings

    Science.gov (United States)

    Fernald, Peter S.

    2004-01-01

    The Monte Carlo Quiz (MCQ), a single-item quiz, is so named because chance, with the roll of a die, determines (a) whether the quiz is administered; (b) the specific article, chapter, or section of the assigned reading that the quiz covers; and (c) the particular question that makes up the quiz. The MCQ encourages both punctual completion and deep…

  7. The GI Bilk

    Science.gov (United States)

    Risener, Randall

    1976-01-01

    What to do about the billion-dollar GI Bill overpayment problem is a question confronting many community college administrators and the Veterans' Administration. Legal and administrative technicalities are reviewed, and it is suggested that many Vietnam era veterans may have no qualms about accepting checks from a government they feel has betrayed…

  8. Integrating an Information Literacy Quiz into the Learning Management System

    Science.gov (United States)

    Lowe, M. Sara; Booth, Char; Tagge, Natalie; Stone, Sean

    2014-01-01

    The Claremont Colleges Library Instruction Services Department developed a quiz that could be integrated into the consortial learning management software to accompany a local online, open-source information literacy tutorial. The quiz is integrated into individual course pages, allowing students to receive a grade for completion and improving…

  9. From Snapshot to Snapchat

    DEFF Research Database (Denmark)

    Christensen, Jørgen Riber; Hansen, Julie Cecilie; Larsen, Frederik Holm

    2015-01-01

    the snapshot tied to leisure (“the Kodak moment”) and Snapchat. The second is empirical, and it uses pre-existing statistics about Snapchat and a questionnaire survey carried out for this article. Finally, the article sees the Snapchat phenomenon in the light of pertinent schools of cultural theory...

  10. Single snapshot DOA estimation

    Science.gov (United States)

    Häcker, P.; Yang, B.

    2010-10-01

    In array signal processing, direction of arrival (DOA) estimation has been studied for decades. Many algorithms have been proposed and their performance has been studied thoroughly. Yet, most of these works are focused on the asymptotic case of a large number of snapshots. In automotive radar applications like driver assistance systems, however, only a small number of snapshots of the radar sensor array or, in the worst case, a single snapshot is available for DOA estimation. In this paper, we investigate and compare different DOA estimators with respect to their single snapshot performance. The main focus is on the estimation accuracy and the angular resolution in multi-target scenarios including difficult situations like correlated targets and large target power differences. We will show that some algorithms lose their ability to resolve targets or do not work properly at all. Other sophisticated algorithms do not show a superior performance as expected. It turns out that the deterministic maximum likelihood estimator is a good choice under these hard conditions.

  11. Miscellaneous GI studies

    International Nuclear Information System (INIS)

    Hansell, J.

    1988-01-01

    The use of radiotracers has served as a valuable adjunct to the myriad of methods available to the physiologist and clinician for measuring various parameters of gastrointestinal (GI) function. The advantage of the technique that employs a radioactive label is the ability to measure function by noninvasive means with relatively little discomfort to the subject. Procedures of this type consist usually of administration of a radioactive form of a substance, by either the oral or intravenous route, followed by radioassay of postadministration samples of body fluids, excreta, or breath. On occasion the body itself is used as the definitive sample for radioassay

  12. Blood Pressure Quiz | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... this page please turn Javascript on. Feature: High Blood Pressure Blood Pressure Quiz Past Issues / Fall 2011 Table of Contents Blood pressure changes throughout the day. It… is highest while ...

  13. Orthopedic Health: Osteoarthritis— What You Should Know (quiz)

    Science.gov (United States)

    ... Bar Home Current Issue Past Issues Orthopedic Health Osteoarthritis— What You Should Know Past Issues / Spring 2009 ... Javascript on. How much do you know about osteoarthritis, its causes, and its therapies? Take this quiz ...

  14. Fetal Alcohol Spectrum Disorders (FASDs): Alcohol Use Quiz

    Science.gov (United States)

    ... Links to Other Websites About Us More CDC Alcohol Topics CDC Alcohol Portal Excessive Alcohol Use Binge ... of alcohol screening and counseling for all women Alcohol Use Quiz Recommend on Facebook Tweet Share Compartir ...

  15. A Quiz on Recent Court Decisions Concerning Student Conduct.

    Science.gov (United States)

    Zirkel, Perry A.

    1980-01-01

    Presents a 10-question quiz based on court decisions reported from 1977 through 1979. Three areas are covered--student discipline, student searches, and student expression. Answers and explanations are given for each question. (IRT)

  16. COPD Quiz | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... please turn JavaScript on. Feature: The Challenge of COPD COPD Quiz Past Issues / Fall 2014 Table of Contents ... Only one answer is correct . Questions Question 1. COPD is a lung disease that: usually starts during ...

  17. Robust snapshot interferometric spectropolarimetry.

    Science.gov (United States)

    Kim, Daesuk; Seo, Yoonho; Yoon, Yonghee; Dembele, Vamara; Yoon, Jae Woong; Lee, Kyu Jin; Magnusson, Robert

    2016-05-15

    This Letter describes a Stokes vector measurement method based on a snapshot interferometric common-path spectropolarimeter. The proposed scheme, which employs an interferometric polarization-modulation module, can extract the spectral polarimetric parameters Ψ(k) and Δ(k) of a transmissive anisotropic object by which an accurate Stokes vector can be calculated in the spectral domain. It is inherently strongly robust to the object 3D pose variation, since it is designed distinctly so that the measured object can be placed outside of the interferometric module. Experiments are conducted to verify the feasibility of the proposed system. The proposed snapshot scheme enables us to extract the spectral Stokes vector of a transmissive anisotropic object within tens of msec with high accuracy.

  18. Lower GI Series (Barium Enema)

    Science.gov (United States)

    ... uses x-rays and a chalky liquid called barium to view your large intestine . The barium will make your large intestine more visible on ... single-contrast lower GI series, which uses only barium a double-contrast or air-contrast lower GI ...

  19. Quiz Lounge Game-Based Learning on Mobile Devices

    Directory of Open Access Journals (Sweden)

    Bettina Harriehausen-Mühlbauer

    2013-08-01

    Full Text Available The Quiz Lounge project is a collaboration between Hochschule Darmstadt and Lufthansa AG. The goal of the project was the development of a mobile learning application. With the application, the Lufthansa managers should be able to learn about data privacy topics playfully and interactively. The application is based on a quiz concept and asks the user for answers to a series of ten questions which increase in difficulty level. While playing the game the user can use two "lifeline" helpers, the audience- and the 50-50-helper. Furthermore, the user has the ability to browse a glossary of related terms if he or she has the need of more detailed knowledge. New questions and also new games can be added with a web-based authoring tool. The authoring tool was uniquely developed for the Quiz Lounge application and conforms to the specific needs of its architecture.

  20. Stimulating Student Interest in Physiology: The Intermedical School Physiology Quiz

    Science.gov (United States)

    Cheng, Hwee-Ming

    2010-01-01

    The Intermedical School Physiology Quiz (IMSPQ) was initiated in 2003 during the author's last sabbatical from the University of Malaya. At this inaugural event, there were just seven competing teams from Malaysian medical schools. The challenge trophy for the IMSPQ is named in honor of Prof. A. Raman, who was the first Malaysian Professor of…

  1. Reliability and validity of the Incontinence Quiz-Turkish version.

    Science.gov (United States)

    Kara, Kerime C; Çıtak Karakaya, İlkim; Tunalı, Nur; Karakaya, Mehmet G

    2018-01-01

    The aim of this study was to investigate the reliability and validity of the Turkish version of the Incontinence Quiz, which was developed by Branch et al. (1994), to assess women's knowledge of and attitudes toward urinary incontinence. Comprehensibility of the Turkish version of the 14-item Incontinence Quiz, which was prepared following translation-back translation procedures, was tested on a pilot group of eight women, and its internal reliability, test-retest reliability and construct validity were assessed in 150 women who attended the gynecology clinics of three hospitals in İçel, Turkey. Physical and sociodemographic characteristics and presence of incontinence complaints were also recorded. Data were analyzed at the 0.05 alpha level, using SPSS version 22. The scale had good reliability and validity. The internal reliability coefficient (Cronbach α) was 0.80, test-retest correlation coefficients were 0.83-0.94; and with regard to construct validity, Kaiser-Meyer-Olkin coefficient was 0.76 and Barlett sphericity test was 562.777 (P = 0.000). Turkish version of the Incontinence Quiz had a four-factor structure, with Eigenvalues ranging from 1.17 to 4.08. The Incontinence Quiz-Turkish version is a highly comprehensible, reliable and valid scale, which may be used to assess Turkish-speaking women's knowledge of and attitudes toward urinary incontinence. © 2017 Japan Society of Obstetrics and Gynecology.

  2. Using Reading Guides and On-Line Quizzes to Improve Reading Compliance and Quiz Scores

    Science.gov (United States)

    Maurer, Trent W.; Longfield, Judith

    2015-01-01

    This study compared students' daily in-class reading quiz scores in an introductory Child Development course across five conditions: control, reading guide only, reading guide and on-line practice quiz, reading guide and on-line graded quiz, and reading guide and both types of on-line quizzes. At the beginning of class, students completed a 5-item…

  3. Interferometric snapshot spectro-ellipsometry.

    Science.gov (United States)

    Dembele, Vamara; Jin, Moonseob; Choi, Inho; Chegal, Won; Kim, Daesuk

    2018-01-22

    We propose a snapshot spectroscopic ellipsometry and its applications for real-time thin-film thickness measurement. The proposed system employs an interferometric polarization-modulation module that can measure the spectroscopic ellipsometric phase for thin-film deposited on a substrate with a measurement speed of around 20 msec. It requires neither moving parts nor time dependent modulation devices. The accuracy of the proposed interferometric snapshot spectro-ellipsometer is analyzed through comparison with commercial equipment results.

  4. From Information to Experience: Christoph Schlingensief's Quiz 3000

    Directory of Open Access Journals (Sweden)

    Tara Forrest

    2014-03-01

    Full Text Available When German artist Christoph Schlingensief died in 2010 he had amassed an impressive body of work spanning a diverse range of fields, including film, television, theatre, art, radio, activism, and opera. Although he gained a certain notoriety for his early film and performance work, it was through his politically engaged re-enactment of a series of reality television programs that his public profile in Germany was cemented. This article focuses on the pilot episode of Quiz 3000 that was staged at the Volksbühne in 2002 and that was modelled closely on the popular reality format Who Wants to be a Millionaire? As Schlingensief has made clear in an interview with Alexander Kluge, his interest in re-enactment as a critical strategy is not driven by a desire for total verisimilitude, but by the inconsistencies that are generated in the re-enactment process that serve as catalysts for reflection and debate. In Quiz 3000 it is the nature of the questions posed to the contestants (such as: 'The rape of members of which minority group is, according to the German criminal code, less heavily penalized?' and 'How many conscientious objectors from Kurdistan have, since 2001, been tortured to death in Turkey after being deported by Germany?' that generates the inconsistency in question. Drawing on Walter Benjamin and Theodor Adorno's writings on information and experience, I argue that Quiz 3000 transforms the information-driven focus of television quiz shows into a source of experience for viewers and contestants alike by encouraging them to reflect on political issues and debates in an autonomous, affective, and meaningful way.

  5. Euro Heart Survey 2009 Snapshot

    DEFF Research Database (Denmark)

    Puymirat, Etienne; Battler, Alex; Birkhead, John

    2013-01-01

    Detailed data on patients admitted for acute myocardial infarction (AMI) on a European-wide basis are lacking. The Euro Heart Survey 2009 Snapshot was designed to assess characteristics, management, and hospital outcomes of AMI patients throughout European Society of Cardiology (ESC) member...

  6. Web-Based Quiz-Game-Like Formative Assessment: Development and Evaluation

    Science.gov (United States)

    Wang, Tzu-Hua

    2008-01-01

    This research aims to develop a multiple-choice Web-based quiz-game-like formative assessment system, named GAM-WATA. The unique design of "Ask-Hint Strategy" turns the Web-based formative assessment into an online quiz game. "Ask-Hint Strategy" is composed of "Prune Strategy" and "Call-in Strategy".…

  7. Self-Assessment Quiz Taking Behaviour Analysis in an Online Course

    Science.gov (United States)

    Ozarslan, Yasin; Ozan, Ozlem

    2016-01-01

    Self-assessment is vital for online learning since it is one of the most essential skills of distance learners. In this respect, the purpose of this study was to understand learners' self-assessment quiz taking behaviours in an undergraduate level online course. We tried to figure out whether there is a relation between self-assessment quiz taking…

  8. Sherlock: A Semi-automatic Framework for Quiz Generation Using a Hybrid Semantic Similarity Measure.

    Science.gov (United States)

    Lin, Chenghua; Liu, Dong; Pang, Wei; Wang, Zhe

    In this paper, we present a semi-automatic system (Sherlock) for quiz generation using linked data and textual descriptions of RDF resources. Sherlock is distinguished from existing quiz generation systems in its generic framework for domain-independent quiz generation as well as in the ability of controlling the difficulty level of the generated quizzes. Difficulty scaling is non-trivial, and it is fundamentally related to cognitive science. We approach the problem with a new angle by perceiving the level of knowledge difficulty as a similarity measure problem and propose a novel hybrid semantic similarity measure using linked data. Extensive experiments show that the proposed semantic similarity measure outperforms four strong baselines with more than 47 % gain in clustering accuracy. In addition, we discovered in the human quiz test that the model accuracy indeed shows a strong correlation with the pairwise quiz similarity.

  9. Building a taxonomy of GI knowledge

    DEFF Research Database (Denmark)

    Arleth, Mette

    2004-01-01

    This paper reports on and ongoing study concerning non-professional users` understanding of GI. Online access to GI are offered by many public authorities, in order to make the public able to serve them selves online and gain insight in the physical planning and area administration. The aim...... of this project is to investigate how and how well non-professional users actually understand GI. For that purpose a taxonomy of GI knowledge is built, drawing on Bloom`s taxonomy. The elements of this taxonomy are described after a presentation of the main research question of the study, the applications chosen...

  10. How Effective are Your Mentoring Relationships? Mentoring Quiz for Residents.

    Science.gov (United States)

    Wadhwa, Vibhor; Nagy, Paul; Chhabra, Avneesh; Lee, Cindy S

    Mentoring is an essential part of a resident's career development. It plays an important role in nurturing, and sustaining success along the career path of a young physician. Mentoring is a long-term goal that is development-driven rather than performance-driven. Although specific learning goals may be used as a basis, the focus of mentoring may also include self-confidence, self-perception, and work-life balance. A number of residency programs have implemented mentoring programs in their institutions. This article discusses the importance of mentoring, illustrates "do's and don'ts" for mentees and demonstrates how to choose the ideal mentor. Finally, a "mentoring quiz" is designed to evaluate your mentoring relationship. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. Quiz commercial game adaptation to help in the radioprotection training

    International Nuclear Information System (INIS)

    Rodrigues Junior, Ary de Araujo

    2002-01-01

    An employee will be qualified to operate a gamma irradiation facility at EMBRARAD after doing a radiation protection training of at least 18 months. After that, the main radiation protection subjects are revised every six months. In that half-yearly training the operators become teachers and so they explain the radiation protection subjects, under the supervision of an instructor. After some years attending the same training, operators do not have motivation to participate in this kind of periodic event due to the same issues covered. Therefore something should be made to revival their interest and motivation to take part in this periodic training. The way chose was adapted a quiz commercial game to revised radiation protection subjects and included it in the periodic training. The game was well accepted by the operators, it caused a competition among them because everybody wanted to win the game and consequently stimulated them to study. (author)

  12. Cost effectiveness of surveillance for GI cancers

    NARCIS (Netherlands)

    Omidvari, A.-H. (Amir-Houshang); R.G.S. Meester (Reinier); I. Lansdorp-Vogelaar (Iris)

    2016-01-01

    textabstractGastrointestinal (GI) diseases are among the leading causes of death in the world. To reduce the burden of GI diseases, surveillance is recommended for some diseases, including for patients with inflammatory bowel diseases, Barrett's oesophagus, precancerous gastric lesions, colorectal

  13. Anesthesia related Complications in Pediatric GI Endoscopy

    Directory of Open Access Journals (Sweden)

    A Sabzevari

    2014-04-01

    Full Text Available Introduction: Elective upper and lower GI endoscopy is usually performed in children on an outpatient basis with the child under sedation or general anesthesia (GA. The objective of this study was to describe Anesthesia related complications in   children undergoing elective GI endoscopy.   Materials and Methods: The study design was descriptive on 1388 patients undergoing elective GI endoscopy in Sheikh Hospital from 2009 to 2013. All patient received propofol or standard inhalational anesthesia. We examined patients’ demographic data  ,  location of GI endoscopy ,  perioperative vital singe ,  recovery time , respiratory and cardiac complications , post operative nausea and vomiting , agitation , diagnosis and outcome   Results: Pediatric patients aged 2 to 17 years. 29 % of elective GI endoscopy was upper GI endoscopy and 70.3 % was lower GI endoscopy and 0.7 was both of them. 47.7 % of Pediatric patients were female and 52.3 % was male. We haven’t significant or fatal anesthesia related respiratory and cardiac complications (no apnea, no cardiac arrest. 8 patients (0.5% have transient bradicardia in post operative care Unit. 83 patients (5.9% have post operative nausea and vomiting controlled by medication.  6 patients (0.4% have post operative agitation controlled by medication.   Conclusions: General anesthesia and deep sedation in children undergoing elective GI endoscopy haven’t significant or fatal anesthesia related complications. We suggest Anesthesia for infants, young children, children with neurologic impairment, and some anxious older children undergoing elective GI endoscopy. Keyword: Anesthesia, Complication, Endoscopy, Pediatric.

  14. Diet Quality Scores of Australian Adults Who Have Completed the Healthy Eating Quiz.

    Science.gov (United States)

    Williams, Rebecca L; Rollo, Megan E; Schumacher, Tracy; Collins, Clare E

    2017-08-15

    Higher scores obtained using diet quality and variety indices are indicators of more optimal food and nutrient intakes and lower chronic disease risk. The aim of this paper is to describe the overall diet quality and variety in a sample of Australian adults who completed an online diet quality self-assessment tool, the Healthy Eating Quiz. The Healthy Eating Quiz takes approximately five minutes to complete online and computes user responses into a total diet quality score (out of a maximum of 73 points) and then categorizes them into the following groups: 'needs work' (Healthy eating quiz scores were higher in those aged 45-75 years compared to 16-44 years ( p Healthy Eating Quiz data indicates that individuals receiving feedback on how to improve their score can improve their diet quality, there is a need for further nutrition promotion interventions in Australian adults.

  15. Special Section: Complementary and Alternative Medicine (CAM):Quiz on Complementary and Alternative Medicine

    Science.gov (United States)

    ... Special Section CAM Quiz on Complementary and Alternative Medicine Past Issues / Winter 2009 Table of Contents For ... low back pain. True False Complementary and alternative medicine (CAM) includes: Meditation Chiropractic Use of natural products, ...

  16. Multiple and single snapshot compressive beamforming

    DEFF Research Database (Denmark)

    Gerstoft, Peter; Xenaki, Angeliki; Mecklenbrauker, Christoph F.

    2015-01-01

    and multiple snapshots. CS does not require inversion of the data covariance matrix and thus works well even for a single snapshot where it gives higher resolution than conventional beamforming. For multiple snapshots, CS outperforms conventional high-resolution methods even with coherent arrivals and at low......-lagged superposition of source amplitudes at all hypothetical DOAs. Regularizing with an ‘1-norm constraint renders the problem solvable with convex optimization, and promoting sparsity gives highresolution DOA maps. Here the sparse source distribution is derived using maximum a posteriori estimates for both single...

  17. Oomägi 1941 / Mart Mõniste

    Index Scriptorium Estoniae

    Mõniste, Mart

    2016-01-01

    Oomägi on koht, kus 1941. aastal toimusid hukkamised. 1988. aastal avati Hiiumaa Muinsuskaitse Seltsi korraldusel Ristimäel (Oomäel) mälestusrist 1941. aasta hukkamis- ja matmispaiga tähistamiseks

  18. Electric Vehicles--A Historical Snapshot

    Science.gov (United States)

    Kraft, Thomas E.

    2012-01-01

    Most people don't realize that the history of electric vehicles (EVs) predates the Civil War. This article provides a historical snapshot of EVs to spark the interest of both teachers and students in this important transportation technology.

  19. Reliability measures in managing GI bleeding.

    Science.gov (United States)

    Sonnenberg, Amnon

    2012-06-01

    Multiple procedures and devices are used in a complex interplay to diagnose and treat GI bleeding. To model how a large variety of diagnostic and therapeutic components interact in the successful management of GI bleeding. The analysis uses the concept of reliability block diagrams from probability theory to model management outcome. Separate components of the management process are arranged in a serial or parallel fashion. If the outcome depends on the function of each component individually, such components are modeled to be arranged in series. If components complement each other and can mutually compensate for each of their failures, such components are arranged in a parallel fashion. General endoscopy practice. Patients with GI bleeding of unknown etiology. All available endoscopic and radiographic means to diagnose and treat GI bleeding. Process reliability in achieving hemostasis. Serial arrangements tend to reduce process reliability, whereas parallel arrangements increase it. Whenever possible, serial components should be bridged and complemented by additional alternative (parallel) routes of operation. Parallel components with low individual reliability can still contribute to overall process reliability as long as they function independently of other pre-existing alternatives. Probability of success associated with individual components is partly unknown. Modeling management of GI bleeding by a reliability block diagram provides a useful tool in assessing the impact of individual endoscopic techniques and administrative structures on the overall outcome. Copyright © 2012 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.

  20. Cost effectiveness of surveillance for GI cancers.

    Science.gov (United States)

    Omidvari, Amir-Houshang; Meester, Reinier G S; Lansdorp-Vogelaar, Iris

    2016-12-01

    Gastrointestinal (GI) diseases are among the leading causes of death in the world. To reduce the burden of GI diseases, surveillance is recommended for some diseases, including for patients with inflammatory bowel diseases, Barrett's oesophagus, precancerous gastric lesions, colorectal adenoma, and pancreatic neoplasms. This review aims to provide an overview of the evidence on cost-effectiveness of surveillance of individuals with GI conditions predisposing them to cancer, specifically focussing on the aforementioned conditions. We searched the literature and reviewed 21 studies. Despite heterogeneity of studies in terms of settings, study populations, surveillance strategies and outcomes, most reviewed studies suggested at least some surveillance of patients with these GI conditions to be cost-effective. For some high-risk conditions frequent surveillance with 3-month intervals was warranted, while for other conditions, surveillance may only be cost-effective every 10 years. Further studies based on more robust effectiveness evidence are needed to inform and optimise surveillance programmes for GI cancers. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. GI-conf: A configuration tool for the GI-cat distributed catalog

    Science.gov (United States)

    Papeschi, F.; Boldrini, E.; Bigagli, L.; Mazzetti, P.

    2009-04-01

    In this work we present a configuration tool for the GI-cat. In an Service-Oriented Architecture (SOA) framework, GI-cat implements a distributed catalog service providing advanced capabilities, such as: caching, brokering and mediation functionalities. GI-cat applies a distributed approach, being able to distribute queries to the remote service providers of interest in an asynchronous style, and notifies the status of the queries to the caller implementing an incremental feedback mechanism. Today, GI-cat functionalities are made available through two standard catalog interfaces: the OGC CSW ISO and CSW Core Application Profiles. However, two other interfaces are under testing: the CIM and the EO Extension Packages of the CSW ebRIM Application Profile. GI-cat is able to interface a multiplicity of discovery and access services serving heterogeneous Earth and Space Sciences resources. They include international standards like the OGC Web Services -i.e. OGC CSW, WCS, WFS and WMS, as well as interoperability arrangements (i.e. community standards) such as: UNIDATA THREDDS/OPeNDAP, SeaDataNet CDI (Common Data Index), GBIF (Global Biodiversity Information Facility) services, and SibESS-C infrastructure services. GI-conf implements user-friendly configuration tool for GI-cat. This is a GUI application that employs a visual and very simple approach to configure both the GI-cat publishing and distribution capabilities, in a dynamic way. The tool allows to set one or more GI-cat configurations. Each configuration consists of: a) the catalog standards interfaces published by GI-cat; b) the resources (i.e. services/servers) to be accessed and mediated -i.e. federated. Simple icons are used for interfaces and resources, implementing a user-friendly visual approach. The main GI-conf functionalities are: • Interfaces and federated resources management: user can set which interfaces must be published; besides, she/he can add a new resource, update or remove an already federated

  2. The normal bacterial flora prevents GI disease

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. The normal bacterial flora prevents GI disease. Inhibits pathogenic enteric bacteria. Decrease luminal pH; Secrete bacteriocidal proteins; Colonization resistance; Block epithelial binding – induce MUC2. Improves epithelial and mucosal barrier integrity. Produce ...

  3. Kultuuritorm Tallinnas / Marko Mägi

    Index Scriptorium Estoniae

    Mägi, Marko

    2001-01-01

    Linnakultuuri Festivalist 20.-27. novembrini Tallinna eri paikades. Muusikaüritustest Von Krahli Teatris: "Tallinn: psühhedeelne linn" ja samanimelise heliplaadi esitlusest; rockmaratonist Operation B; tribuutkontserdist Sven Grünbergile ja S. Grünbergi kolmikheliplaadist "Hukkunud alpinisti Hotell"; Raido Mägi ja Mart Kangro moderntantsuetendusest "Meelega. Start.based on a true story"

  4. Forensic SNP genotyping with SNaPshot

    DEFF Research Database (Denmark)

    Fondevila, M; Børsting, C; Phillips, C

    2017-01-01

    to routine STR profiling, use of SNaPshot is an important part of the development of SNP sets for a wide range of forensic applications with these markers, from genotyping highly degraded DNA with very short amplicons to the introduction of SNPs to ascertain the ancestry and physical characteristics......This review explores the key factors that influence the optimization, routine use, and profile interpretation of the SNaPshot single-base extension (SBE) system applied to forensic single-nucleotide polymorphism (SNP) genotyping. Despite being a mainly complimentary DNA genotyping technique...... of an unidentified contact trace donor. However, this technology, as resourceful as it is, displays several features that depart from the usual STR genotyping far enough to demand a certain degree of expertise from the forensic analyst before tackling the complex casework on which SNaPshot application provides...

  5. Discovery of flare activity on the dwarf M stars, GI 375 and GI 431

    Energy Technology Data Exchange (ETDEWEB)

    Doyle, J.G.; Mathioudakis, M.; Panagi, P.M.; Butler, C.J. (Armagh Observatory, (IE))

    1990-12-01

    Optical and infrared photometry plus spectroscopic data is present for two new flare stars, GI 375 and GI 431. Both of these stars have the hydrogen Balmer lines strongly in emission. Several flares were detected on GI 375 implying a high level of flare activity. The H{alpha} surface flux of 1.0 x 10{sup 6} erg cm{sup -2}s{sup -1} for both stars is similar to that of other active flare stars. Fluxes are given for several of the higher Balmer lines.

  6. Psychometric Properties of the Revised Facts on Suicide Quiz in Austrian Medical and Psychology Undergraduates

    Science.gov (United States)

    Voracek, Martin; Tran, Ulrich S.; Sonneck, Gernot

    2008-01-01

    Psychometric properties and demographic correlates of a German form of R. W. Hubbard and J. L. McIntosh's (1992) Revised Facts on Suicide Quiz (RFOS), an inventory for assessing overall knowledge about suicide, were investigated in a sample of 1,093 Austrian medical and psychology students. Internal consistency of the RFOS was weak, as were many…

  7. The Effectiveness Evaluation among Different Player-Matching Mechanisms in a Multi-Player Quiz Game

    Science.gov (United States)

    Tsai, Fu-Hsing

    2016-01-01

    This study aims to investigate whether different player-matching mechanisms in educational multi-player online games (MOGs) can affect students' learning performance, enjoyment perception and gaming behaviors. Based on the multi-player quiz game, TRIS-Q, developed by Tsai, Tsai and Lin (2015) using a free player-matching (FPM) mechanism, the same…

  8. The Use of a Daily Quiz" TOPday" as Supportive Learning Method for Medical Students

    NARCIS (Netherlands)

    Maessen, Martijn FH; Fluit, Cornelia RMG; Holla, Micha; Drost, Gea; Vorstenbosch, Marc ATM; de Waal Malefijt, Maarten C; Kooloos, Jan GM; Tanck, Esther

    2016-01-01

    Medical students consider anatomy, neurology, and traumatology as difficult study topics. A recent study showed that the daily quiz ‘Two Opportunities to Practice per day (TOPday)’ positively supported biomedical students in analyzing and solving biomechanical problems. The main purpose of this

  9. Misconceptions Highlighted among Medical Students in the Annual International Intermedical School Physiology Quiz

    Science.gov (United States)

    Cheng, Hwee-Ming; Durairajanayagam, Damayanthi

    2012-01-01

    The annual Intermedical School Physiology Quiz (IMSPQ), initiated in 2003, is now an event that attracts a unique, large gathering of selected medical students from medical schools across the globe. The 8th IMSPQ, in 2010, hosted by the Department of Physiology, University of Malaya, in Kuala Lumpur, Malaysia, had 200 students representing 41…

  10. The Use of a Daily Quiz "TOPday" as Supportive Learning Method for Medical Students

    Science.gov (United States)

    Maessen, Martijn F. H.; Fluit, Cornelia R. M. G.; Holla, Micha; Drost, Gea; Vorstenbosch, Marc A. T. M.; de Waal Malefijt, Maarten C.; Kooloos, Jan G. M.; Tanck, Esther

    2016-01-01

    Medical students consider anatomy, neurology, and traumatology as difficult study topics. A recent study showed that the daily quiz "Two Opportunities to Practice per day (TOPday)" positively supported biomedical students in analyzing and solving biomechanical problems. The main purpose of this study was to investigate the effect of…

  11. A Comparison of Escalating versus Fixed Reinforcement Schedules on Undergraduate Quiz Taking

    Science.gov (United States)

    Mahoney, Amanda

    2017-01-01

    Drug abstinence studies indicate that escalating reinforcement schedules maintain abstinence for longer periods than fixed reinforcement schedules. The current study evaluated whether escalating reinforcement schedules would maintain more quiz taking than fixed reinforcement schedules. During baseline and for the control group, bonus points were…

  12. "UML Quiz": Automatic Conversion of Web-Based E-Learning Content in Mobile Applications

    Science.gov (United States)

    von Franqué, Alexander; Tellioglu, Hilda

    2014-01-01

    Many educational institutions use Learning Management Systems to provide e-learning content to their students. This often includes quizzes that can help students to prepare for exams. However, the content is usually web-optimized and not very usable on mobile devices. In this work a native mobile application ("UML Quiz") that imports…

  13. Personal Health and Finance Quiz: A Tool for Outreach, Research, and Evaluation

    Directory of Open Access Journals (Sweden)

    Barbara O'Neill

    2015-02-01

    Full Text Available Rutgers Cooperative Extension developed an online self-assessment tool called the Personal Health and Finance Quiz available at http://njaes.rutgers.edu/money/health-finance-quiz/. Believed to be among the first public surveys to simultaneously query users about their health and personal finance practices, the quiz is part of Small Steps to Health and Wealth™ (SSHW, a Cooperative Extension program developed to motivate Americans to take action to improve both their health and personal finances (see http://njaes.rutgers.edu/sshw/. Respondents indicate one of four frequencies for performance of 20 daily activities and receive a Health, Finance, and Total score indicating their frequency of performing activities that health and financial experts recommend. In addition to providing users with personalized feedback, the quiz collects data for research about the health and financial practices of Americans to inform future Extension outreach and can be used as a pre-/post-test to evaluate the impact of SSHW programs. Initial research analyses are planned for 2015.

  14. Incorporating a quiz into informed consent processes: Qualitative study of participants' reactions

    Directory of Open Access Journals (Sweden)

    Marsh Vicki

    2007-11-01

    Full Text Available Abstract Background Formal checks of participant understanding are now widely recommended to improve informed consent processes. However, the views of the participants these assessments are designed to protect are rarely considered. In this paper the findings of a qualitative study aimed at documenting community reactions to a semi-structured questionnaire ('quiz' are reported. The quiz was administered to 189 mothers after consenting for their children to participate in a malaria vaccine trial on the Kenyan Coast. Methods Once the malaria vaccine trial was underway, focus group discussions were held with some of these mothers (nine groups; 103 mothers, and with community-based field staff attached to the malaria vaccine trial (two groups of five workers. Individual interviews with other trial staff were also held. Results The quiz prompted community members to voice concerns about blood sampling and vaccine side-effects, thereby encouraging additional discussions and interactions between the research team and potential study participants. However, it also caused significant upset and concern. Some of the quiz questions, or the way in which they were asked, appeared to fuel misconceptions and fears, with potentially negative consequences for both the study and community members. Conclusion Formal approaches to checking study understanding should be employed with sensitivity and caution. They are influenced by and impact upon complex social relationships between and among researchers and community members. Adequate consideration of these contexts in assessments of understanding, and in responding to the issues raised, requires strong social science capacity.

  15. Sauerbraten, Rotkappchen und Goethe: The Quiz Show as an Introduction to German Studies.

    Science.gov (United States)

    White, Diane

    1980-01-01

    Proposes an adaptation of the quiz-show format for classroom use, discussing a set of rules and sample questions designed for beginning and intermediate German students. Presents questions based on German life and culture which are especially selected to encourage participation from students majoring in subjects other than German. (MES)

  16. A Snapshot from the European Educational Landscape

    NARCIS (Netherlands)

    Boddin, F.; Graham, Todd; Schmitt, L.; Sujon, Z.; Carpentier, Nico; Pruulmann-Vengerfeldt, Pille; Nordenstreng, Kaarle; Hartmann, Maren; Vihalemm, Peeter; Cammaerts, Bart; Nieminen, Hannu

    2007-01-01

    In this chapter, we present a snapshot of the European doctoral landscape based on the reflections of 40 doctoral students gathered from throughout the European Union for the ECREA Doctoral Summer School. One of this school’s main objectives is to ‘generate a wide picture of the international

  17. CALiPER Snapshot Report: Troffers

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2016-12-01

    Snapshot reports use data from DOE's LED Lighting Facts product list to compare the LED performance to standard technologies, and are designed to help lighting retailers, distributors, designers, utilities, energy efficiency program sponsors, and other stakeholders understand the current state of the LED market and its trajectory.

  18. SnapShot: The Bacterial Cytoskeleton.

    Science.gov (United States)

    Fink, Gero; Szewczak-Harris, Andrzej; Löwe, Jan

    2016-07-14

    Most bacteria and archaea contain filamentous proteins and filament systems that are collectively known as the bacterial cytoskeleton, though not all of them are cytoskeletal, affect cell shape, or maintain intracellular organization. To view this SnapShot, open or download the PDF. Copyright © 2016. Published by Elsevier Inc.

  19. CALiPER Snapshot Report: Downlight - 2017

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2017-07-30

    Snapshot reports use data from DOE's LED Lighting Facts product list to compare the LED performance to standard technologies, and are designed to help lighting retailers, distributors, designers, utilities, energy efficiency program sponsors, and other stakeholders understand the current state of the LED market and its trajectory.

  20. CALiPER Snapshot Report: Downlight - 2016

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2016-04-01

    Snapshot reports use data from DOE's LED Lighting Facts product list to compare the LED performance to standard technologies, and are designed to help lighting retailers, distributors, designers, utilities, energy efficiency program sponsors, and other stakeholders understand the current state of the LED market and its trajectory.

  1. CALiPER Snapshot Report: Industrial Luminaires

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2017-03-01

    Snapshot reports use data from DOE's LED Lighting Facts product list to compare the LED performance to standard technologies, and are designed to help lighting retailers, distributors, designers, utilities, energy efficiency program sponsors, and other stakeholders understand the current state of the LED market and its trajectory.

  2. Accessibility of GI for Public Participation

    DEFF Research Database (Denmark)

    Arleth, Mette; Campagna, Michele

    2005-01-01

    The paper reports an ongoing comparative study on the accessibility of Geographic Information at public authorities’ websites in Denmark and Italy. The purpose of the study is twofold; to give an idea of the latest development and diffusion of GI on public authorities websites, and to identify...... critical factors for success or failure of the applications. First part of the study therefore consists of a mapping of the level of accessibility of GI in the two countries as a comparative analysis. The focus of the mapping is mainly on the use of geographic information as support to citizens......’ involvement in spatial e-government and planning processes. Then, in the reminder of the paper, a comparative analysis is proposed outlining similarities and divergences in critical success factors in the two examined domains....

  3. Key steps in developing a cognitive vaccine against traumatic flashbacks: visuospatial Tetris versus verbal Pub Quiz.

    Science.gov (United States)

    Holmes, Emily A; James, Ella L; Kilford, Emma J; Deeprose, Catherine

    2010-11-10

    Flashbacks (intrusive memories of a traumatic event) are the hallmark feature of Post Traumatic Stress Disorder, however preventative interventions are lacking. Tetris may offer a 'cognitive vaccine' [1] against flashback development after trauma exposure. We previously reported that playing the computer game Tetris soon after viewing traumatic material reduced flashbacks compared to no-task [1]. However, two criticisms need to be addressed for clinical translation: (1) Would all games have this effect via distraction/enjoyment, or might some games even be harmful? (2) Would effects be found if administered several hours post-trauma? Accordingly, we tested Tetris versus an alternative computer game--Pub Quiz--which we hypothesized not to be helpful (Experiments 1 and 2), and extended the intervention interval to 4 hours (Experiment 2). The trauma film paradigm was used as an experimental analog for flashback development in healthy volunteers. In both experiments, participants viewed traumatic film footage of death and injury before completing one of the following: (1) no-task control condition (2) Tetris or (3) Pub Quiz. Flashbacks were monitored for 1 week. Experiment 1: 30 min after the traumatic film, playing Tetris led to a significant reduction in flashbacks compared to no-task control, whereas Pub Quiz led to a significant increase in flashbacks. Experiment 2: 4 hours post-film, playing Tetris led to a significant reduction in flashbacks compared to no-task control, whereas Pub Quiz did not. First, computer games can have differential effects post-trauma, as predicted by a cognitive science formulation of trauma memory. In both Experiments, playing Tetris post-trauma film reduced flashbacks. Pub Quiz did not have this effect, even increasing flashbacks in Experiment 1. Thus not all computer games are beneficial or merely distracting post-trauma - some may be harmful. Second, the beneficial effects of Tetris are retained at 4 hours post-trauma. Clinically

  4. User Profile Analysis Using an Online Social Network Integrated Quiz Game

    Directory of Open Access Journals (Sweden)

    Yusuf YASLAN

    2017-09-01

    Full Text Available User interest profiling is important for personalized web search, recommendation and retrieval systems. In order to develop a good personalized application one needs to have accurate representation of user profiles. Most of the personalized systems generate interest profiles from user declarations or inferred from cookies or visited web pages. But to achieve a certain result that satisfies the user needs, explicit definition of the user interests is needed. In this paper we propose to obtain interest profiles from a quiz game played by the user where at each play he/she is asked 10 questions from different categories with different difficulty levels. The developed quiz game is integrated to Facebook online social network. By doing so, we had the chance to extract each user’s both explicit Facebook interest profiles and implicit interest profiles from quiz game answers. These profiles are used to extract different features for each user. Both implicit interest profile and explicit interest profile features are evaluated for clustering and interest ranking tasks separately. The experimental results show that the implicit interest profile features have promising results on personalized systems.

  5. The use of quizStar application for online examination in basic physics course

    Science.gov (United States)

    Kustijono, R.; Budiningarti, H.

    2018-03-01

    The purpose of the study is to produce an online Basic Physics exam system using the QuizStar application. This is a research and development with ADDIE model. The steps are: 1) analysis; 2) design; 3) development; 4) implementation; 5) evaluation. System feasibility is reviewed for its validity, practicality, and effectiveness. The subjects of research are 60 Physics Department students of Universitas Negeri Surabaya. The data analysis used is a descriptive statistic. The validity, practicality, and effectiveness scores are measured using a Likert scale. Criteria feasible if the total score of all aspects obtained is ≥ 61%. The results obtained from the online test system by using QuizStar developed are 1) conceptually feasible to use; 2) the system can be implemented in the Basic Physics assessment process, and the existing constraints can be overcome; 3) student's response to system usage is in a good category. The results conclude that QuizStar application is eligible to be used for online Basic Physics exam system.

  6. Key steps in developing a cognitive vaccine against traumatic flashbacks: visuospatial Tetris versus verbal Pub Quiz.

    Directory of Open Access Journals (Sweden)

    Emily A Holmes

    2010-11-01

    Full Text Available Flashbacks (intrusive memories of a traumatic event are the hallmark feature of Post Traumatic Stress Disorder, however preventative interventions are lacking. Tetris may offer a 'cognitive vaccine' [1] against flashback development after trauma exposure. We previously reported that playing the computer game Tetris soon after viewing traumatic material reduced flashbacks compared to no-task [1]. However, two criticisms need to be addressed for clinical translation: (1 Would all games have this effect via distraction/enjoyment, or might some games even be harmful? (2 Would effects be found if administered several hours post-trauma? Accordingly, we tested Tetris versus an alternative computer game--Pub Quiz--which we hypothesized not to be helpful (Experiments 1 and 2, and extended the intervention interval to 4 hours (Experiment 2.The trauma film paradigm was used as an experimental analog for flashback development in healthy volunteers. In both experiments, participants viewed traumatic film footage of death and injury before completing one of the following: (1 no-task control condition (2 Tetris or (3 Pub Quiz. Flashbacks were monitored for 1 week. Experiment 1: 30 min after the traumatic film, playing Tetris led to a significant reduction in flashbacks compared to no-task control, whereas Pub Quiz led to a significant increase in flashbacks. Experiment 2: 4 hours post-film, playing Tetris led to a significant reduction in flashbacks compared to no-task control, whereas Pub Quiz did not.First, computer games can have differential effects post-trauma, as predicted by a cognitive science formulation of trauma memory. In both Experiments, playing Tetris post-trauma film reduced flashbacks. Pub Quiz did not have this effect, even increasing flashbacks in Experiment 1. Thus not all computer games are beneficial or merely distracting post-trauma - some may be harmful. Second, the beneficial effects of Tetris are retained at 4 hours post

  7. Enabling interoperability in Geoscience with GI-suite

    Science.gov (United States)

    Boldrini, Enrico; Papeschi, Fabrizio; Santoro, Mattia; Nativi, Stefano

    2015-04-01

    GI-suite is a brokering framework targeting interoperability of heterogeneous systems in the Geoscience domain. The framework is composed by different brokers each one focusing on a specific functionality: discovery, access and semantics (i.e. GI-cat, GI-axe, GI-sem). The brokering takes place between a set of heterogeneous publishing services and a set of heterogeneous consumer applications: the brokering target is represented by resources (e.g. coverages, features, or metadata information) required to seamlessly flow from the providers to the consumers. Different international and community standards are now supported by GI-suite, making possible the successful deployment of GI-suite in many international projects and initiatives (such as GEOSS, NSF BCube and several EU funded projects). As for the publisher side more than 40 standards and implementations are supported (e.g. Dublin Core, OAI-PMH, OGC W*S, Geonetwork, THREDDS Data Server, Hyrax Server, etc.). The support for each individual standard is provided by means of specific GI-suite components, called accessors. As for the consumer applications side more than 15 standards and implementations are supported (e.g. ESRI ArcGIS, Openlayers, OGC W*S, OAI-PMH clients, etc.). The support for each individual standard is provided by means of specific profiler components. The GI-suite can be used in different scenarios by different actors: - A data provider having a pre-existent data repository can deploy and configure GI-suite to broker it and making thus available its data resources through different protocols to many different users (e.g. for data discovery and/or data access) - A data consumer can use GI-suite to discover and/or access resources from a variety of publishing services that are already publishing data according to well-known standards. - A community can deploy and configure GI-suite to build a community (or project-specific) broker: GI-suite can broker a set of community related repositories and

  8. SnapShot: Phosphoregulation of Mitosis.

    Science.gov (United States)

    Burgess, Andrew; Vuong, Jenny; Rogers, Samuel; Malumbres, Marcos; O'Donoghue, Seán I

    2017-06-15

    During mitosis, a cell divides its duplicated genome into two identical daughter cells. This process must occur without errors to prevent proliferative diseases (e.g., cancer). A key mechanism controlling mitosis is the precise timing of more than 32,000 phosphorylation and dephosphorylation events by a network of kinases and counterbalancing phosphatases. The identity, magnitude, and temporal regulation of these events have emerged recently, largely from advances in mass spectrometry. Here, we show phosphoevents currently believed to be key regulators of mitosis. For an animated version of this SnapShot, please see http://www.cell.com/cell/enhanced/odonoghue2. Copyright © 2017. Published by Elsevier Inc.

  9. Snapshot hyperspectral imaging and practical applications

    International Nuclear Information System (INIS)

    Wong, G

    2009-01-01

    Traditional broadband imaging involves the digital representation of a remote scene within a reduced colour space. Hyperspectral imaging exploits the full spectral dimension, which better reflects the continuous nature of actual spectra. Conventional techniques are all time-delayed whereby spatial or spectral scanning is required for hypercube generation. An innovative and patented technique developed at Heriot-Watt University offers significant potential as a snapshot sensor, to enable benefits for the wider public beyond aerospace imaging. This student-authored paper seeks to promote awareness of this field within the photonic community and its potential advantages for real-time practical applications.

  10. Snapshot of an integrated psychosocial gastroenterology service.

    Science.gov (United States)

    Kinsinger, Sarah W; Ballou, Sarah; Keefer, Laurie

    2015-02-14

    To characterize the patients utilizing a gastroenterology behavioral medicine service and examine the effect of treatment on health care utilization. Patients were referred by their gastroenterologists for psychological treatment during a 15 mo period. Patients seen for an intake with a psychologist completed the Brief Symptom Inventory (BSI) and a checklist of psychosocial concerns. A subset of patients with functional bowel disorders also completed a disease specific quality of life measure. Chart review was conducted to obtain information on type and frequency of sessions with the psychologist, the number of outpatient gastroenterology visits, and number of gastroenterology-related medical procedures during the 6 mo following psychological intake. Of 259 patients referred for treatment, 118 (46%) completed an intake with a psychologist. Diagnoses included: irritable bowel syndrome (42%), functional dyspepsia (20%), inflammatory bowel diseases (20%), esophageal symptoms (10%), and "other" (8%). Demographic variables and disease type did not differentiate between those who did and did not schedule an intake. Mean t-scores for the BSI global score index and the depression, anxiety, and somatization subscales fell below the cutoff for clinical significance (t = 63). Treatments were predominantly gut-directed hypnosis (48%) and cognitive behavioral therapy (44%). Average length of treatment was 4 sessions. Among functional gastrointestinal (GI) patients, those patients who initiated treatment received significantly fewer GI-related medical procedures during the 6 mo following the referral than patients who did not schedule an intake [t (197) = 2.69, P < 0.01]. Patients are receptive to psychological interventions for GI conditions and there is preliminary evidence that treatment can decrease health-care utilization among patients with functional GI conditions.

  11. Formalized Verification of Snapshotable Trees: Separation and Sharing

    DEFF Research Database (Denmark)

    Mehnert, Hannes; Sieczkowski, Filip; Birkedal, Lars

    2012-01-01

    We use separation logic to specify and verify a Java program that implements snapshotable search trees, fully formalizing the speci- cation and verication in the Coq proof assistant. We achieve local and modular reasoning about a tree and its snapshots and their iterators, al- though...... for full functional specication and verication, whether by separation logic or by other formalisms....

  12. Verification of Snapshotable Trees using Access Permissions and Typestate

    DEFF Research Database (Denmark)

    Mehnert, Hannes; Aldrich, Jonathan

    2012-01-01

    We use access permissions and typestate to specify and ver- ify a Java library that implements snapshotable search trees, as well as some client code. We formalize our approach in the Plural tool, a sound modular typestate checking tool. We describe the challenges to verify- ing snapshotable tree...

  13. Beliefs About GI Medications and Adherence to Pharmacotherapy in Functional GI Disorder Outpatients

    Science.gov (United States)

    Cassell, Benjamin; Gyawali, C. Prakash; Kushnir, Vladimir M.; Gott, Britt M.; Nix, Billy D.; Sayuk, Gregory S.

    2016-01-01

    OBJECTIVES Pharmacotherapy is a mainstay in functional gastrointestinal (GI) disorder (FGID) management, but little is known about patient attitudes toward medication regimens. Understanding patient concerns and adherence to pharmacotherapy is particularly important for off-label medication use (e.g., anti-depressants) in FGID. METHODS Consecutive tertiary GI outpatients completed the Beliefs About Medications questionnaire (BMQ). Subjects were categorized as FGID and structural GI disease (SGID) using clinician diagnoses and Rome criteria; GI-specific medications and doses were recorded, and adherence to medication regimens was determined by patient self-report. BMQ domains (overuse, harm, necessity, and concern) were compared between FGID and SGID, with an interest in how these beliefs affected medication adherence. Psychiatric measures (depression, anxiety, and somatization) were assessed to gauge their influence on medication beliefs. RESULTS A total of 536 subjects (mean age 54.7±0.7 years, range 22–100 years; n=406, 75.7% female) were enrolled over a 5.5-year interval: 341 (63.6%) with FGID (IBS, 64.8%; functional dyspepsia, 51.0%, ≥2 FGIDs, 38.7%) and 142 (26.5%) with SGID (IBD, 28.9%; GERD, 23.2%). PPIs (n=231, 47.8%), tricyclic antidepressants (TCAs) (n=167, 34.6%), and anxiolytics (n=122, 25.3%) were common medications prescribed. FGID and SGID were similar across all BMQ domains (P>0.05 for overuse, harm, necessity, and concern). SGID subjects had higher necessity-concern framework (NCF) scores compared with FGID subjects ( P=0.043). FGID medication adherence correlated negatively with concerns about medication harm (r=−0.24, P<0.001) and overuse (r=−0.15, P=0.001), whereas higher NCF differences predicted medication compliance (P=0.006). Medication concern and overuse scores correlated with psychiatric comorbidity among FGID subjects (P<0.03 for each). FGID patients prescribed TCAs (n=142, 41.6%) expressed a greater medication necessity (17.4

  14. Kidney Quiz

    Science.gov (United States)

    ... Cares Peers Support Ask the Doctor My Food Coach Nutrition Dialysis Patient & Family Resources Emergency Resources A ... State Charity Registration Disclosures © 2017 National Kidney Foundation, Inc., 30 East 33rd Street, New York, NY 10016, ...

  15. Asthma Quiz

    Science.gov (United States)

    ... Conditions Drug Guide Conditions Dictionary Just for Kids Library School Tools Videos Virtual Allergist Education & Training Careers in ... Support the AAAAI Foundation Donate Utility navigation Español Journals Annual Meeting Member Login / My Membership Search navigation ...

  16. Pregnancy Quiz

    Science.gov (United States)

    ... women need more of certain vitamins, minerals, and proteins including calcium, folic acid, and iron. Rest and try not to over do it. While you are pregnant, you might not be able to do everything ...

  17. Clenbuterol-Stimulated Glucose Uptake Activates both GS and GI ...

    African Journals Online (AJOL)

    β2-adrenoceptors activated by adrenaline can also couple to both Gs and Gi proteins. The former is associated with an increase in cAMP to illicit the effect of the catecholamine. In the later, β2-AR induces PKA-catalysed phosphorylation of the receptor, which intends couples to Gi, at high concentration. We proposed that ...

  18. Õhuvägi loobus USA pakutud lennukitest

    Index Scriptorium Estoniae

    2016-01-01

    Eesti õhuvägi loobus USA poolt kingituseks pakutud kahest sõjaväe transportlennukist Sherpa C-23B+. Põhjalikuma analüüsi tulemusel on kaalumisel alternatiivsed variandid ja Sherpasid õhuvägi praeguse seisuga kasutusse ei võta, ütles kaitseväe peastaabi pressiesindaja

  19. Internationally recognised armed forces / Urmas Roosimägi

    Index Scriptorium Estoniae

    Roosimägi, Urmas

    1999-01-01

    Eesti Kaitseväe juhataja kohusetäitja kolonel Urmas Roosimägi Eesti kaitseväest, osalemisest NATO-PFP (NATO-Partnership for Peace) programmis ja sõjalisest koostööst NATO partnerriikidega. Urmas Roosimägi biograafia. Programm Partnerlus Rahu Nimel

  20. Do clinical and translational science graduate students understand linear regression? Development and early validation of the REGRESS quiz.

    Science.gov (United States)

    Enders, Felicity

    2013-12-01

    Although regression is widely used for reading and publishing in the medical literature, no instruments were previously available to assess students' understanding. The goal of this study was to design and assess such an instrument for graduate students in Clinical and Translational Science and Public Health. A 27-item REsearch on Global Regression Expectations in StatisticS (REGRESS) quiz was developed through an iterative process. Consenting students taking a course on linear regression in a Clinical and Translational Science program completed the quiz pre- and postcourse. Student results were compared to practicing statisticians with a master's or doctoral degree in statistics or a closely related field. Fifty-two students responded precourse, 59 postcourse , and 22 practicing statisticians completed the quiz. The mean (SD) score was 9.3 (4.3) for students precourse and 19.0 (3.5) postcourse (P REGRESS quiz was internally reliable (Cronbach's alpha 0.89). The initial validation is quite promising with statistically significant and meaningful differences across time and study populations. Further work is needed to validate the quiz across multiple institutions. © 2013 Wiley Periodicals, Inc.

  1. Writing Games: Continuity and Change in the Design and Development of Quiz Shows in Italy

    Directory of Open Access Journals (Sweden)

    Massimo Scaglioni

    2013-12-01

    Full Text Available As in the United States and in many countries across Europe, the quiz show was a founding genre for Italian television as far back as the 1950s: because of their broad appeal, such game shows as Lascia o raddoppia and Il musichiere contributed strongly to television’s burgeoning popularity during the subsequent decades. Since then, the quiz show has traversed different eras of television history, with partial and gradual changes to its textual features, aesthetics and narratives, as well as its production routines. Since the 1980s, with deregulation and the advent of commercial television, the Italian game-show market has become more international and more reliant on formats. In the genre’s long history, the “hidden profession” of writing TV games exhibits elements of both continuity and change. The needs of format-adaptation have highlighted two main areas of “localization”: question-writing and casting. This essay explores the profession of game-show writer in Italy and how the role has evolved. It adopts a historical framework to illuminate the continuity and change in the profession, in relation to a broader history of both the genre and the television medium, while also seeking to outline both the specificity of the Italian TV context and its connections with an international environment. 

  2. A comparison of the use of virtual versus physical snapshots for supporting update-intensive workloads

    DEFF Research Database (Denmark)

    Šidlauskas, Darius; Jensen, Christian S.; Šaltenis, Simonas

    2012-01-01

    and one for the frequent and very localized updates. The snapshot that receives the updates is frequently made available to queries, so that queries see up-to-date data. The snapshots may be physical or virtual. Physical snapshots are created using the C library memcpy function. Virtual snapshots...

  3. Snapshot analysis for rhodium fixed incore detector using BEACON methodology

    International Nuclear Information System (INIS)

    Cha, Kyoon Ho; Choi, Yu Sun; Lee, Eun Ki; Park, Moon Ghu; Morita, Toshio; Heibel, Michael D.

    2004-01-01

    The purpose of this report is to process the rhodium detector data of the Yonggwang nuclear unit 4 cycle 5 core for the measured power distribution by using the BEACON methodology. Rhodium snapshots of the YGN 4 cycle 5 have been analyzed by both BEACON/SPINOVA and CECOR to compare the results of both codes. By analyzing a large number of snapshots obtained during normal plant operation. Reviewing the results of this analysis, the BEACON/SPNOVA can be used for the snapshot analysis of Korean Standard Nuclear Power (KSNP) plants

  4. Vasks: Cantabile per archi, Paul Mägi / Bernhard Uske

    Index Scriptorium Estoniae

    Uske, Bernhard

    1994-01-01

    Uuest heliplaadist "Vasks: Cantabile per archi; Botschaft: Musica Dolorosa, Sinfonie für Streicher (Stimmen). Latvijas Nicionalais Simfoniskais Orkestris, Latvijas Filharmonijas Kamerorkestris. Pauls Megi [Paul Mägi]", Tovijs Lifsics. Wergo CD 6220-2

  5. Energy Transition Initiative, Island Energy Snapshot - Grenada (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    2015-03-01

    This profile provides a snapshot of the energy landscape of Grenada - a small island nation consisting of the island of Grenada and six smaller islands in the southeastern Caribbean Sea - three of which are inhabited: Grenada, Carriacou, and Petite Martinique.

  6. Extending the GI Brokering Suite to Support New Interoperability Specifications

    Science.gov (United States)

    Boldrini, E.; Papeschi, F.; Santoro, M.; Nativi, S.

    2014-12-01

    The GI brokering suite provides the discovery, access, and semantic Brokers (i.e. GI-cat, GI-axe, GI-sem) that empower a Brokering framework for multi-disciplinary and multi-organizational interoperability. GI suite has been successfully deployed in the framework of several programmes and initiatives, such as European Union funded projects, NSF BCube, and the intergovernmental coordinated effort Global Earth Observation System of Systems (GEOSS). Each GI suite Broker facilitates interoperability for a particular functionality (i.e. discovery, access, semantic extension) among a set of brokered resources published by autonomous providers (e.g. data repositories, web services, semantic assets) and a set of heterogeneous consumers (e.g. client applications, portals, apps). A wide set of data models, encoding formats, and service protocols are already supported by the GI suite, such as the ones defined by international standardizing organizations like OGC and ISO (e.g. WxS, CSW, SWE, GML, netCDF) and by Community specifications (e.g. THREDDS, OpenSearch, OPeNDAP, ESRI APIs). Using GI suite, resources published by a particular Community or organization through their specific technology (e.g. OPeNDAP/netCDF) can be transparently discovered, accessed, and used by different Communities utilizing their preferred tools (e.g. a GIS visualizing WMS layers). Since Information Technology is a moving target, new standards and technologies continuously emerge and are adopted in the Earth Science context too. Therefore, GI Brokering suite was conceived to be flexible and accommodate new interoperability protocols and data models. For example, GI suite has recently added support to well-used specifications, introduced to implement Linked data, Semantic Web and precise community needs. Amongst the others, they included: DCAT: a RDF vocabulary designed to facilitate interoperability between Web data catalogs. CKAN: a data management system for data distribution, particularly used by

  7. AUTORIA DE QUIZ PARA APLICAÇÃO INTERDISCIPLINAR DE CONHECIMENTOS TRANSVERSAIS

    Directory of Open Access Journals (Sweden)

    Victor Hugo dos Santos

    2011-06-01

    Full Text Available Universities have the mission to provide and to contemplate the general formations, socials and specifics to the students during their graduation courses. Students many times only value their technical formation in their areas, considering uninteresting themes like: Ethics, Health, Environment, Sexual Orientation, Work, Consumption, Cultural Plurality, among others. This project aims the authorship and application of knowledge-based competitions in quiz, built from the knowledge base with questions of traverse themes intuitively formatted and presented in agreement with pre-configured themes. The intention consists of uniting the "non-university" world to university, where students can participate motivated by the dispute and by offer of awards or activity hours for the best. This work was developed using the Visual Studio programming environment for Internet and using the Silverlight multimedia technology to enrich the presentation on the Internet and on the mobile devices.

  8. Teaching Baroreflex Physiology to Medical Students: A Comparison of Quiz-Based and Conventional Teaching Strategies in a Laboratory Exercise

    Science.gov (United States)

    Berg, Ronan M. G.; Plovsing, Ronni R.; Damgaard, Morten

    2012-01-01

    Quiz-based and collaborative teaching strategies have previously been found to be efficient for the improving meaningful learning of physiology during lectures. These approaches have, however, not been investigated during laboratory exercises. In the present study, we compared the impact of solving quizzes individually and in groups with…

  9. On the number of observable customers, served during he busy period of GI/GI/infinity queue

    International Nuclear Information System (INIS)

    Dvurechenskij, A.

    1982-01-01

    It is proved that the number of observable customers, served during the busy period of the GI/GI infinity queue with infinitely many servers has a geometric distribution. The parameter of this distribution is determined, too. It is shown that the normalized distributions converge to the exponential distribution. As a particular result is obtained that the distribution of the number of nonabsorbing streamers in a streamer blob has a geometric distribution

  10. A Gemini snapshot survey for double degenerates

    Science.gov (United States)

    Kilic, Mukremin; Brown, Warren R.; Gianninas, A.; Curd, Brandon; Bell, Keaton J.; Allende Prieto, Carlos

    2017-11-01

    We present the results from a Gemini snapshot radial-velocity survey of 44 low-mass white-dwarf candidates selected from the Sloan Digital Sky Survey (SDSS) spectroscopy. To find sub-hour orbital period binary systems, our time-series spectroscopy had cadences of 2-8 min over a period of 20-30 min. Through follow-up observations at Gemini and the MMT, we identify four double-degenerate binary systems with periods ranging from 53 min to 7 h. The shortest period system, SDSS J123549.88+154319.3, was recently identified as a sub-hour period detached binary by Breedt and collaborators. Here, we refine the orbital and physical parameters of this system. High-speed and time-domain survey photometry observations do not reveal eclipses or other photometric effects in any of our targets. We compare the period distribution of these four systems with the orbital period distribution of known double white dwarfs; the median period decreases from 0.64 to 0.24 d for M = 0.3-0.5 M⊙ to M < 0.3 M⊙ white dwarfs. However, we do not find a statistically significant correlation between the orbital period and white-dwarf mass.

  11. A snapshot of research in learning technology

    Directory of Open Access Journals (Sweden)

    Rhona Sharpe

    2010-12-01

    Full Text Available The papers in this issue present a convenient snapshot of current research in learning technology, both in their coverage of the issues that concern us and the methods that are being used to investigate them. This issue shows that e-learning researchers are interested in: what technologies are available and explorations of their potential (Nie et al. explore the role of podcasting, how to design technology-mediated learning activities in ways which support specific learning outcomes (Simpson evaluates the role of ‘book raps' in supporting critical thinking, the identification of critical success factors in implementations (Cochrane's observation of three mobile learning projects and how such e-learning initiatives can be sustained within an institutional context (Gunn's examination of the challenges of embedding ‘grass roots' initiatives. Finally e-learning research is concerned with investigating the impact of emerging technologies on education – in this case Traxler's discussion of mobile, largely student-owned, devices. Together these five papers demonstrate the scope of research in learning technology and it is with this in mind that we will soon be referring to this journal by its subtitle: Research in Learning Technology.

  12. SSAT Presidential Address 2017 "Passion and the GI Surgeon".

    Science.gov (United States)

    Soper, Nathaniel J

    2018-01-01

    Gastrointestinal (GI) surgery is a dynamic, exciting field that has dramatically evolved over the past three decades. According to a survey of leaders in GI surgery, the development of minimally invasive surgery has been the most significant advance during this period of time. The author traces his pursuit of minimally invasive surgery and its impact on his career satisfaction. Discovering one's passion within surgery and developing "flow" during operative procedures is important to help prevent burnout. Surgical educators must transmit this sense of passion to their trainees such that they can understand the true meaning of the surgical vocation.

  13. From snapshots to social media the changing picture of domestic photography

    CERN Document Server

    Sarvas, Risto

    2011-01-01

    New technology is changing the face of the photograph. This volume on 'snapshot' photography-pictures taken by non-professionals-examines key future trends, from multimedia and social practices to the notion of embedding physicality into digital snapshots.

  14. Prototype of a Questionnaire and Quiz System for Supporting Increase of Health Awareness During Wait Time in Dispensing Pharmacy

    Science.gov (United States)

    Toda, Takeshi; Chen, Poa-Min; Ozaki, Shinya; Ideguchi, Naoko; Miyaki, Tomoko; Nanbu, Keiko; Ikeda, Keiko

    For quit-smoking clinic and its campaign, there was a need for pharmacists to investigate pediatric patient's parent consciousness to tobacco harm utilizing wait time in a pediatric dispensing pharmacy. In this research, we developed the questionnaire and quiz total system using the tablet for user interface, in which people can easily answer the questionnaire/quiz and quickly see the total results on the spot in order to enhance their consciousness to the tobacco harm. The system also provides their tobacco dependence level based on the questionnaire results and some advice for their health and dietary habits due to the tobacco dependence level. From a field trial with one hundred four examinees in the pediatric dispensing pharmacy, the user interface was useful compared to conventional questionnaire form. The system could enhance their consciousness to tobacco harm and make their beneficial use of waiting time in dispensing pharmacy. Some interesting suggestions for improvement and new services were also obtained.

  15. A Web-Based Interactive Homework Quiz and Tutorial Package To Motivate Undergraduate Chemistry Students and Improve Learning

    Science.gov (United States)

    Freasier, Ben; Collins, Grant; Newitt, Paula

    2003-11-01

    This study presents a Web-based interactive homework quiz and tutorial package that we have devised to improve the learning of first-year undergraduate chemistry students. We developed this automated scheme, based on WWWAssign, to produce randomly generated quizzes from a large database of questions, instantaneously grade that homework, give a fully-worked solution, and provide individually targeted tutorial assistance. Success in these quizzes was a necessary requirement before taking supervised tests. We found a positive correlation at the p= 0.1 level (90%) between voluntary extra use of the quizzes in the interactive package and the final course grade. All students undertook more quizzes than the base course requirement even though the quiz grades did not contribute to the total course grades. We suggest that students were motivated to pursue additional practice with the quizzes and associated tutorial information, as they perceived some benefit in this student-centered study tool and could access it at any time.

  16. Snapshot spectral and polarimetric imaging; target identification with multispectral video

    Science.gov (United States)

    Bartlett, Brent D.; Rodriguez, Mikel D.

    2013-05-01

    As the number of pixels continue to grow in consumer and scientific imaging devices, it has become feasible to collect the incident light field. In this paper, an imaging device developed around light field imaging is used to collect multispectral and polarimetric imagery in a snapshot fashion. The sensor is described and a video data set is shown highlighting the advantage of snapshot spectral imaging. Several novel computer vision approaches are applied to the video cubes to perform scene characterization and target identification. It is shown how the addition of spectral and polarimetric data to the video stream allows for multi-target identification and tracking not possible with traditional RGB video collection.

  17. Cardiac and vascular imaging with snapshot FLASH MR imaging

    International Nuclear Information System (INIS)

    Matthaei, D.; Haase, A.; Norris, D.; Leibfritz, D.; Henrich, D.; Duhmke, E.

    1989-01-01

    Acceleration of fast low-angle-shot (FLASH) MR imaging to about 200 msec measuring time on dedicated MR systems is called snapshot FLASH MR imaging. It snaps real-time series of MR images of the MR relaxation and of physiologic motions with nearly absent motion and susceptibility artifacts. Results in animals (4.7T) and human volunteers (2.0T) show plain vascular and cardiac snapshot FLASH MR images obtained as single shot, triggered reconstructed motion, or real-time films. The reduction of artifacts and the high resolution (triggered, three-dimensional moving heart images are possible) result in favorable applications in myocardial and great vascular disease

  18. Augmenting College Students' Study of Speech-Language Pathology Using Computer-Based Mini Quiz Games.

    Science.gov (United States)

    Vinney, Lisa A; Howles, Les; Leverson, Glen; Connor, Nadine P

    2016-08-01

    This study examined whether undergraduate college students' immediate recall and longer-term retention of introductory voice disorder concepts improved by using mini quiz games (MQGs; interactive knowledge tests in game format) compared with (a) traditional study alone, (b) MQGs and traditional study together, or (c) a no-study control condition. Ninety-three college students participated in proctored sessions in which they were given a pretest, viewed an online lecture on introductory voice disorder concepts, and then engaged in either no intervention or interventions including traditional study, MQG play, or both MQG play and traditional study, followed by an immediate recall posttest and longer-term retention follow-up test. Analyses suggested that the effects of all interventions (traditional study, MQG play, and the combination of the 2) were equivalent and resulted in significantly greater improvements from pretest to immediate recall posttest performance than the control condition. In contrast, MQGs and MQGs with traditional study, but not traditional study alone, showed better results for long-term retention than no study. Results provide preliminary support for the idea that there may be multiple effective learning modes, beyond traditional study, that enhance recall and retention of knowledge foundational to speech-language pathology clinical training and practice.

  19. Analysis of Students’ Missed Organic Chemistry Quiz Questions that Stress the Importance of Prior General Chemistry Knowledge

    OpenAIRE

    Julie Ealy

    2018-01-01

    A concern about students’ conceptual difficulties in organic chemistry prompted this study. It was found that prior knowledge from general chemistry was critical in organic chemistry, but what were some of the concepts that comprised that prior knowledge? Therefore an analysis of four years of organic chemistry quiz data was undertaken. Multiple general chemistry concepts were revealed that are essential prior knowledge in organic chemistry. The general chemistry concepts that were foun...

  20. Lenz, Eestis unustatud geenius / Riina Mägi

    Index Scriptorium Estoniae

    Mägi, Riina, 1957-

    2001-01-01

    Tartus toimunud rahvusvahelise Lenzi-konverentsi (Jakob Michael Reinhold Lenz) publik nägi väljasõidul Põltsamaale Lenzi kirjutatud näidendit "Haavatud peigmees", mis esitati Tartu üliõpilasteatri poolt Põltsamaa lossihoovis. Lav. Kalev Kudu

  1. The food, GI tract functionality and human health cluster

    NARCIS (Netherlands)

    Mattila-Sandholm, T.; Blaut, M.; Daly, C.; Vuyst, de L.; Dore, J.; Gibson, G.; Goossens, H.; Knorr, D.; Lucas, J.; Lahteenmaki, L.; Mercenier, A.M.E.; Saarela, M.; Shanahan, F.; Vos, de W.M.

    2002-01-01

    The Food, GI-tract Functionality and Human Health (PROEUHEALTH) Cluster brings together eight complementary, multicentre interdisciplinary research projects. All have the common aim of improving the health and quality of life of European comsumers. The collaboration involves 64 different research

  2. Eesti uued helid / Tristan Priimägi

    Index Scriptorium Estoniae

    Priimägi, Tristan, 1976-

    2009-01-01

    Tristan Priimägi kuulab digitaalselt uusi kodumaiseid demosalvestisi: Nevesis "Demo", Queennaive "My Soul / EuroPop", DND "Den Rozhdenija EP", Uncandy "Lovecool / Diskobliss / Libidinal Economy", S.I.N. "Year Zero EP" (Omblu) / "Steppin Headz" (XDubz), Spice Mouse "Unreleased"

  3. The queue-length in GI/G/s queues

    Directory of Open Access Journals (Sweden)

    Le Gall Pierre

    2000-01-01

    Full Text Available The distribution of the queue-length in the stationary symmetrical GI/G/s queue is given with an application to the M/G/s queue, particularly in the case of the combination of several packet traffics, with various constant service times, to dimension the buffer capacity.

  4. Empty Promise: Black American Veterans and the New GI Bill

    Science.gov (United States)

    Ottley, Alford H.

    2014-01-01

    The 2008 GI Bill offers college funds for veterans. Yet Black male vets are not taking advantage of these benefits. This chapter examines personal and societal problems that hinder access to higher education for Black vets, and suggests some ways adult educators can advocate for these young men.

  5. G.I. Taylor and the Trinity Test

    Science.gov (United States)

    Deakin, Michael A. B.

    2011-01-01

    The story is often told of the calculation by G.I. Taylor of the yield of the first ever atomic bomb exploded in New Mexico in 1945. It has indeed become a staple of the classroom whenever dimensional analysis is taught. However, while it is true that Taylor succeeded in calculating this figure at a time when it was still classified, most versions…

  6. CoGI: Towards Compressing Genomes as an Image.

    Science.gov (United States)

    Xie, Xiaojing; Zhou, Shuigeng; Guan, Jihong

    2015-01-01

    Genomic science is now facing an explosive increase of data thanks to the fast development of sequencing technology. This situation poses serious challenges to genomic data storage and transferring. It is desirable to compress data to reduce storage and transferring cost, and thus to boost data distribution and utilization efficiency. Up to now, a number of algorithms / tools have been developed for compressing genomic sequences. Unlike the existing algorithms, most of which treat genomes as one-dimensional text strings and compress them based on dictionaries or probability models, this paper proposes a novel approach called CoGI (the abbreviation of Compressing Genomes as an Image) for genome compression, which transforms the genomic sequences to a two-dimensional binary image (or bitmap), then applies a rectangular partition coding algorithm to compress the binary image. CoGI can be used as either a reference-based compressor or a reference-free compressor. For the former, we develop two entropy-based algorithms to select a proper reference genome. Performance evaluation is conducted on various genomes. Experimental results show that the reference-based CoGI significantly outperforms two state-of-the-art reference-based genome compressors GReEn and RLZ-opt in both compression ratio and compression efficiency. It also achieves comparable compression ratio but two orders of magnitude higher compression efficiency in comparison with XM--one state-of-the-art reference-free genome compressor. Furthermore, our approach performs much better than Gzip--a general-purpose and widely-used compressor, in both compression speed and compression ratio. So, CoGI can serve as an effective and practical genome compressor. The source code and other related documents of CoGI are available at: http://admis.fudan.edu.cn/projects/cogi.htm.

  7. Common data items in seven European oesophagogastric cancer surgery registries: towards a European upper GI cancer audit (EURECCA Upper GI).

    Science.gov (United States)

    de Steur, W O; Henneman, D; Allum, W H; Dikken, J L; van Sandick, J W; Reynolds, J; Mariette, C; Jensen, L; Johansson, J; Kolodziejczyk, P; Hardwick, R H; van de Velde, C J H

    2014-03-01

    Seven countries (Denmark, France, Ireland, the Netherlands, Poland, Sweden, United Kingdom) collaborated to initiate a EURECCA (European Registration of Cancer Care) Upper GI project. The aim of this study was to identify a core dataset of shared items in the different data registries which can be used for future collaboration between countries. Item lists from all participating Upper GI cancer registries were collected. Items were scored 'present' when included in the registry, or when the items could be deducted from other items in the registry. The definition of a common item was that it was present in at least six of the seven participating countries. The number of registered items varied between 40 (Poland) and 650 (Ireland). Among the 46 shared items were data on patient characteristics, staging and diagnostics, neoadjuvant treatment, surgery, postoperative course, pathology, and adjuvant treatment. Information on non-surgical treatment was available in only 4 registries. A list of 46 shared items from seven participating Upper GI cancer registries was created, providing a basis for future quality assurance and research in Upper GI cancer treatment on a European level. Copyright © 2013 Elsevier Ltd. All rights reserved.

  8. A snapshot of noncommunicable disease profiles and their ...

    African Journals Online (AJOL)

    A snapshot of noncommunicable disease profiles and their prescription costs at ten primary healthcare facilities in the in the western half of the Cape Town Metropole. AA Isaacs, N Manga, N Manga, C Le Grange, C Le Grange, DA Hellenberg, DA Hellenberg, V Titus, V Titus, R Sayed, R Sayed ...

  9. Energy Transition Initiative, Island Energy Snapshot - Bahamas (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    2015-02-01

    This profile provides a snapshot of the electricity generation or reduction technologies, including solar hot water heating, available to the Commonwealth of the Bahamas - a country consisting of more than 700 islands, cays, and islets - of which only 30 are actually inhabited. Heating and transportation fuels are not addressed.

  10. Energy Transition Initiative, Island Energy Snapshot - Turks & Caicos (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    2015-02-01

    This profile presents a snapshot of the electricity generation and reduction technologies, including solar hot water heating, available to Turks and Caicos - a British overseas territory consisting of two groups of islands located southeast of the Bahamas. Heating and transportation fuels are not addressed.

  11. CALiPER Snapshot Report: Outdoor Area Lighting - 2017

    Energy Technology Data Exchange (ETDEWEB)

    None

    2017-09-29

    Snapshot reports use data from DOE's LED Lighting Facts product list to compare the LED performance to standard technologies, and are designed to help lighting retailers, distributors, designers, utilities, energy efficiency program sponsors, and other stakeholders understand the current state of the LED market and its trajectory.

  12. A Snapshot of Organizational Climate: Perceptions of Extension Faculty

    Science.gov (United States)

    Tower, Leslie E.; Bowen, Elaine; Alkadry, Mohamad G.

    2011-01-01

    This article provides a snapshot of the perceptions of workplace climate of Extension faculty at a land-grant, research-high activity university, compared with the perceptions of non-Extension faculty at the same university. An online survey was conducted with a validated instrument. The response rate for university faculty was 44% (968); the…

  13. Snapshots of mathematics teacher noticing during task design

    Science.gov (United States)

    Choy, Ban Heng

    2016-09-01

    Designing a mathematically worthwhile task is critical for promoting students' reasoning. To improve task design skills, teachers often engage in collaborative lesson planning activities such as lesson study. However, to learn from the process of lesson study, it is important for teachers to notice productively the concepts, students' confusion and the design of the task. But what researchers mean by productive noticing varies. In this article, I present the FOCUS Framework which highlights two characteristics of productive noticing: having an explicit focus for noticing and focusing noticing through pedagogical reasoning. Using these two characteristics, I develop snapshots of noticing as a representation of practice to present a fine-grained analysis of teacher noticing. Through vignettes of teachers discussing the design of a task to teach fractions, I illustrate how two teachers' noticing can be analysed and represented using snapshots of noticing. To conclude, I highlight what snapshots of noticing tell us about a teacher's noticing and suggest ways to use these snapshots in future studies of noticing.

  14. Pressure spectra from single-snapshot tomographic PIV

    NARCIS (Netherlands)

    Schneiders, J.F.G.; Avallone, F.; Pröbsting, S.; Ragni, D.; Scarano, F.

    2018-01-01

    The power spectral density and coherence of temporal pressure fluctuations are obtained from low-repetition-rate tomographic PIV measurements. This is achieved by extension of recent single-snapshot pressure evaluation techniques based upon the Taylor’s hypothesis (TH) of frozen turbulence and

  15. Energy Transition Initiative: Island Energy Snapshot - St. Lucia (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    2015-02-01

    This profile provides a snapshot of the electricity generation or reduction technologies, including solar hot water heating, available to Saint Lucia, one of six Caribbean countries that make up the Windward Islands - the southern arc of the Lesser Antilles chain - at the eastern end of the Caribbean Sea. Heating and transportation fuels are not addressed.

  16. Piroxicam-β-cyclodextrin: a GI safer piroxicam.

    Science.gov (United States)

    Scarpignato, C

    2013-01-01

    Although NSAIDs are very effective drugs, their use is associated with a broad spectrum of adverse reactions in the liver, kidney, cardiovascular (CV) system, skin and gut. Gastrointestinal (GI) side effects are the most common and constitute a wide clinical spectrum ranging from dyspepsia, heartburn and abdominal discomfort to more serious events such as peptic ulcer with life-threatening complications of bleeding and perforation. The appreciation that CV risk is also increased further complicates the choices of physicians prescribing anti-inflammatory therapy. Despite prevention strategies should be implemented in patients at risk, gastroprotection is often underused and adherence to treatment is generally poor. A more appealing approach would be therefore to develop drugs that are devoid of or have reduced GI toxicity. Gastro- duodenal mucosa possesses many defensive mechanisms and NSAIDs have a deleterious effect on most of them. This results in a mucosa less able to cope with even a reduced acid load. NSAIDs cause gastro-duodenal damage, by two main mechanisms: a physiochemical disruption of the gastric mucosal barrier and systemic inhibition of gastric mucosal protection, through inhibition of cyclooxygenase (COX, PG endoperoxide G/H synthase) activity of the GI mucosa. However, against a background of COX inhibition by anti-inflammatory doses of NSAIDs, their physicochemical properties, in particular their acidity, underlie the topical effect leading to short-term damage. It has been shown that esterification of acidic NSAIDs suppresses their gastrotoxicity without adversely affecting anti-inflammatory activity. Another way to develop NSAIDs with better GI tolerability is to complex these molecules with cyclodextrins (CDs), giving rise to so-called "inclusion complexes" that can have physical, chemical and biological properties very different from either those of the drug or the cyclodextrin. Complexation of NSAIDs with β-cyclodextrin potentially leads to a

  17. Treatment of GI dysmotility in scleroderma with the new enterokinetic agent prucalopride

    NARCIS (Netherlands)

    Boeckxstaens, G. E.; Bartelsman, J. F. W. M.; Lauwers, L.; Tytgat, G. N. J.

    2002-01-01

    Scleroderma is a multisystem disorder frequently resulting in disturbed GI motility. Although, especially early in the disease, symptomatic improvement is achieved with prokinetic agents, more severe GI manifestations of scleroderma may be difficult to treat, leading to parenteral feeding and

  18. Evaluating compliance to a low glycaemic index (GI diet in women with polycystic ovary syndrome (PCOS

    Directory of Open Access Journals (Sweden)

    Atiomo William

    2011-03-01

    Full Text Available Abstract Background A low Glycaemic Index (GI diet may decrease some long-term health risks in Polycystic Ovary Syndrome (PCOS such as endometrial cancer. This study was performed to assess compliance to a low GI diet in women with PCOS. Food diaries prospectively collected over 6 months from women on a low GI diet or healthy eating diet were analysed retrospectively. The women were recruited for a pilot randomised control trial investigating whether a low GI diet decreased the risk of Endometrial Cancer. Nine women with PCOS completed 33 food diaries (17 from women on a low GI diet and 16 from women on a healthy eating diet recording 3023 food items (low GI group:n = 1457; healthy eating group:n = 1566. Data was analysed using Foster-Powell international values inserted into an SPSS database as no scientifically valid established nutrition software was found. The main outcome measures were mean item GI and Glyacemic Load (GL, mean meal GL, percentage high GI foods and mean weight loss. Findings Women allocated the low GI diet had a statistically significant lower GI of food items (33.67 vs 36.91, p Conclusion Women with PCOS on a low GI diet consumed food items with a significantly lower mean GI and GL compared to the healthy eating diet group. Longer term compliance needs evaluation in subsequent studies to ascertain that this translates to reduced long term health risks. Trial Registration ISRCTN: ISRCTN86420258

  19. An instrument to measure nurses' knowledge in palliative care: Validation of the Spanish version of Palliative Care Quiz for Nurses.

    Directory of Open Access Journals (Sweden)

    Elena Chover-Sierra

    Full Text Available Palliative care is nowadays essential in nursing care, due to the increasing number of patients who require attention in final stages of their life. Nurses need to acquire specific knowledge and abilities to provide quality palliative care. Palliative Care Quiz for Nurses is a questionnaire that evaluates their basic knowledge about palliative care. The Palliative Care Quiz for Nurses (PCQN is useful to evaluate basic knowledge about palliative care, but its adaptation into the Spanish language and the analysis of its effectiveness and utility for Spanish culture is lacking.To report the adaptation into the Spanish language and the psychometric analysis of the Palliative Care Quiz for Nurses.The Palliative Care Quiz for Nurses-Spanish Version (PCQN-SV was obtained from a process including translation, back-translation, comparison with versions in other languages, revision by experts, and pilot study. Content validity and reliability of questionnaire were analyzed. Difficulty and discrimination indexes of each item were also calculated according to Item Response Theory (IRT.Adequate internal consistency was found (S-CVI = 0.83; Cronbach's alpha coefficient of 0.67 and KR-20 test result of 0,72 reflected the reliability of PCQN-SV. The questionnaire had a global difficulty index of 0,55, with six items which could be considered as difficult or very difficult, and five items with could be considered easy or very easy. The discrimination indexes of the 20 items, show us that eight items are good or very good while six items are bad to discriminate between good and bad respondents.Although in shows internal consistency, reliability and difficulty indexes similar to those obtained by versions of PCQN in other languages, a reformulation of the items with lowest content validity or discrimination indexes and those showing difficulties with their comprehension is an aspect to take into account in order to improve the PCQN-SV.The PCQN-SV is a useful

  20. Dual-camera design for coded aperture snapshot spectral imaging.

    Science.gov (United States)

    Wang, Lizhi; Xiong, Zhiwei; Gao, Dahua; Shi, Guangming; Wu, Feng

    2015-02-01

    Coded aperture snapshot spectral imaging (CASSI) provides an efficient mechanism for recovering 3D spectral data from a single 2D measurement. However, since the reconstruction problem is severely underdetermined, the quality of recovered spectral data is usually limited. In this paper we propose a novel dual-camera design to improve the performance of CASSI while maintaining its snapshot advantage. Specifically, a beam splitter is placed in front of the objective lens of CASSI, which allows the same scene to be simultaneously captured by a grayscale camera. This uncoded grayscale measurement, in conjunction with the coded CASSI measurement, greatly eases the reconstruction problem and yields high-quality 3D spectral data. Both simulation and experimental results demonstrate the effectiveness of the proposed method.

  1. SnapShot: Fanconi anemia and associated proteins.

    Science.gov (United States)

    Wang, Anderson T; Smogorzewska, Agata

    2015-01-15

    Fanconi anemia is a genetic disorder resulting from biallelic mutations in one of the 17 FANC genes. It is characterized by congenital abnormalities, bone marrow failure, and cancer predisposition. The underlying cause is genomic instability resulting from the deficiency in replication-dependent DNA interstrand crosslink repair pathway commonly referred to as the Fanconi anemia-BRCA pathway. This SnapShot presents the key factors involved. Copyright © 2015 Elsevier Inc. All rights reserved.

  2. Limited-memory adaptive snapshot selection for proper orthogonal decomposition

    Energy Technology Data Exchange (ETDEWEB)

    Oxberry, Geoffrey M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Kostova-Vassilevska, Tanya [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Arrighi, Bill [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Chand, Kyle [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-04-02

    Reduced order models are useful for accelerating simulations in many-query contexts, such as optimization, uncertainty quantification, and sensitivity analysis. However, offline training of reduced order models can have prohibitively expensive memory and floating-point operation costs in high-performance computing applications, where memory per core is limited. To overcome this limitation for proper orthogonal decomposition, we propose a novel adaptive selection method for snapshots in time that limits offline training costs by selecting snapshots according an error control mechanism similar to that found in adaptive time-stepping ordinary differential equation solvers. The error estimator used in this work is related to theory bounding the approximation error in time of proper orthogonal decomposition-based reduced order models, and memory usage is minimized by computing the singular value decomposition using a single-pass incremental algorithm. Results for a viscous Burgers’ test problem demonstrate convergence in the limit as the algorithm error tolerances go to zero; in this limit, the full order model is recovered to within discretization error. The resulting method can be used on supercomputers to generate proper orthogonal decomposition-based reduced order models, or as a subroutine within hyperreduction algorithms that require taking snapshots in time, or within greedy algorithms for sampling parameter space.

  3. Optimization of compressive 4D-spatio-spectral snapshot imaging

    Science.gov (United States)

    Zhao, Xia; Feng, Weiyi; Lin, Lihua; Su, Wu; Xu, Guoqing

    2017-10-01

    In this paper, a modified 3D computational reconstruction method in the compressive 4D-spectro-volumetric snapshot imaging system is proposed for better sensing spectral information of 3D objects. In the design of the imaging system, a microlens array (MLA) is used to obtain a set of multi-view elemental images (EIs) of the 3D scenes. Then, these elemental images with one dimensional spectral information and different perspectives are captured by the coded aperture snapshot spectral imager (CASSI) which can sense the spectral data cube onto a compressive 2D measurement image. Finally, the depth images of 3D objects at arbitrary depths, like a focal stack, are computed by inversely mapping the elemental images according to geometrical optics. With the spectral estimation algorithm, the spectral information of 3D objects is also reconstructed. Using a shifted translation matrix, the contrast of the reconstruction result is further enhanced. Numerical simulation results verify the performance of the proposed method. The system can obtain both 3D spatial information and spectral data on 3D objects using only one single snapshot, which is valuable in the agricultural harvesting robots and other 3D dynamic scenes.

  4. Giant gastric lipoma presenting as GI bleed: Enucleation or Resection?

    Directory of Open Access Journals (Sweden)

    Salah Termos

    Full Text Available Introduction: Gastric lipomas are unusual benign lesions and account for less than 1% of all tumours of the stomach and 5% of all gastrointestinal lipomas (Thompson et al.2003; Fernandez et al. 1983 [1,2]. Although predominantly asymptomatic and indolent; they may present with gastric outlet obstruction and upper gastrointestinal (GI bleeding owing to size and ulceration. Only a few cases have been reported, presenting large in size with massive GI bleeding (Alcalde Escribano et al. 1989; Johnson et al. 1981 [3,4]. Presentation of case: We report the case of a 62-year-old gentleman who presented to the emergency department with massive upper GI hemorrhage. He was initially resuscitated and stabilized. Later gastroscopy showed a large submucosal tumour (Fig. 1. Biopsy revealed adipose tissue. Computed tomography (CT scan of the abdomen and pelvis showed a huge well defined oval soft tissue lesion measuring about 16 × 8 × 8 cm. The mass noted a homogenous fat density arising from the posterior wall of stomach with no extramural infiltration (Fig. 2. The tumour was completely enucleated through an explorative gastrotomy incision (Fig. 4. Discussion and conclusion: Massive bleeding secondary to a giant gastric lipoma is a rare finding of a rare disease. The majority of cases in the literature result in major gastric resection. Familiarity with its radiological findings and a high index of suspicion can lead to proper diagnosis in the acute setting. If malignancy is carefully ruled out, stomach preserving surgery is an optimal treatment option. Keywords: Case report, Lipoma, Gastric lipoma, G I bleeding, Enucleation, Gastric resection

  5. Acute upper GI bleeding: Did anything change? Time trend analysis of incidence and outcome of acute upper GI bleeding between 1993/1994 and 2000

    NARCIS (Netherlands)

    van Leerdam, M. E.; Vreeburg, E. M.; Rauws, E. A. J.; Geraedts, A. A. M.; Tijssen, J. G. P.; Reitsma, J. B.; Tytgat, G. N. J.

    2003-01-01

    OBJECTIVES: The aim of this study was to examine recent time trends in incidence and outcome of upper GI bleeding. METHODS: Prospective data collection on all patients presenting with acute upper GI bleeding from a defined geographical area in the period 1993/1994 and 2000. RESULTS: Incidence

  6. Using an online quiz-based reinforcement system to teach healthcare quality and patient safety and care transitions at the University of California.

    Science.gov (United States)

    Shaikh, Ulfat; Afsar-Manesh, Nasim; Amin, Alpesh N; Clay, Brian; Ranji, Sumant R

    2017-10-01

    Implementing quality improvement (QI) education during clinical training is challenging due to time constraints and inadequate faculty development in these areas. Quiz-based reinforcement systems show promise in fostering active engagement, collaboration, healthy competition and real-time formative feedback, although further research on their effectiveness is required. An online quiz-based reinforcement system to increase resident and faculty knowledge in QI, patient safety and care transitions. Experts in QI and educational assessment at the 5 University of California medical campuses developed a course comprised of 3 quizzes on Introduction to QI, Patient Safety and Care Transitions. Each quiz contained 20 questions and utilized an online educational quiz-based reinforcement system that leveraged spaced learning. Approximately 500 learners completed the course (completion rate 66-86%). Knowledge acquisition scores for all quizzes increased after completion: Introduction to QI (35-73%), Patient Safety (58-95%), and Care Transitions (66-90%). Learners reported that the quiz-based system was an effective teaching modality and preferred this type of education to classroom-based lectures. Suggestions for improvement included reducing frequency of presentation of questions and utilizing more questions that test learners on application of knowledge instead of knowledge acquisition. A multi-campus online quiz-based reinforcement system to train residents in QI, patient safety and care transitions was feasible, acceptable, and increased knowledge. The course may be best utilized to supplement classroom-based and experiential curricula, along with increased attention to optimizing frequency of presentation of questions and enhancing application skills. © The Author 2017. Published by Oxford University Press in association with the International Society for Quality in Health Care. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

  7. Effects of random study checks and guided notes study cards on middle school special education students' notetaking accuracy and science vocabulary quiz scores

    Science.gov (United States)

    Wood, Charles L.

    Federal legislation mandates that all students with disabilities have meaningful access to the general education curriculum and that students with and without disabilities be held equally accountable to the same academic standards (IDEIA, 2004; NCLB, 2001). Many students with disabilities, however, perform poorly in academic content courses, especially at the middle and secondary school levels. Previous research has reported increased notetaking accuracy and quiz scores over lecture content when students completed guided notes compared to taking their own notes. This study evaluated the effects of a pre-quiz review procedure and specially formatted guided notes on middle school special education students' learning of science vocabulary. This study compared the effects of three experimental conditions. (a) Own Notes (ON), (b) Own Notes+Random Study Checks (ON+RSC), and (c) Guided Notes Study Cards+Random Study Checks (GNSC+RSC) on each student's accuracy of notes, next-day quiz scores, and review quiz scores. Each session, the teacher presented 12 science vocabulary terms and definitions during a lecture and students took notes. The students were given 5 minutes to study their notes at the end of each session and were reminded to study their notes at home and in study hall period. In the ON condition students took notes on a sheet of paper with numbered lines from 1 to 12. Just before each next-day quiz in the ON+RSC condition students used write-on response cards to answer two teacher-posed questions over randomly selected vocabulary terms from the previous day's lecture. If the answer on a randomly selected student's response card was correct, that student earned a lottery ticket for inexpensive prizes and a quiz bonus point for herself and each classmate. In the GNSC+RSC condition students took notes on specially formatted guided notes that after the lecture they cut into a set of flashcards that could used for study. The students' mean notetaking accuracy was 75

  8. GiSAO.db: a database for ageing research

    Directory of Open Access Journals (Sweden)

    Grillari Johannes

    2011-05-01

    Full Text Available Abstract Background Age-related gene expression patterns of Homo sapiens as well as of model organisms such as Mus musculus, Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster are a basis for understanding the genetic mechanisms of ageing. For an effective analysis and interpretation of expression profiles it is necessary to store and manage huge amounts of data in an organized way, so that these data can be accessed and processed easily. Description GiSAO.db (Genes involved in senescence, apoptosis and oxidative stress database is a web-based database system for storing and retrieving ageing-related experimental data. Expression data of genes and miRNAs, annotation data like gene identifiers and GO terms, orthologs data and data of follow-up experiments are stored in the database. A user-friendly web application provides access to the stored data. KEGG pathways were incorporated and links to external databases augment the information in GiSAO.db. Search functions facilitate retrieval of data which can also be exported for further processing. Conclusions We have developed a centralized database that is very well suited for the management of data for ageing research. The database can be accessed at https://gisao.genome.tugraz.at and all the stored data can be viewed with a guest account.

  9. A comparative study of digital GI and CT in diagnosis of gastric carcinoma

    International Nuclear Information System (INIS)

    Wan Xiangrong; Chen Guoqin; Ding Xinmin

    2003-01-01

    Objective: To evaluate the digital GI and CT in the diagnosis of gastric carcinoma. Methods: Total 42 patients with gastric carcinoma received digital GI and CT examination. The digital GI and CT findings were analyzed comparatively. Results: 42 cases of patients with gastric carcinoma were examined with digital GI and CT. Digital GI demonstrated mucosal erosion in 40 cases, narrowed gastric lumen in 12, malignant ulceration in 10, filling defect in 12 and abnormal peristalsis in 36. CT revealed gastric wall thickening in 30 cases, intra-gastric masses in 36, narrowed gastric lumen in 36, regional lymphadenopathy and/or distant metastases in 19 and pyloristenosis in 4. Conclusion: The lesions in stomach could be demonstrated on digital GI, the imaging is clear and precise. CT is valuable for assessing the extra-gastric involvement, lymphadenopathy and distant metastases, which is an important pre-operative examination

  10. Clinical approach to obscure GI bleeding - Diagnostic testing and management

    Directory of Open Access Journals (Sweden)

    Prashanth Prabakaran

    2013-01-01

    Full Text Available Obscure gastrointestinal bleeding (OGIB can present as a diagnostic dilemma and management can be challenging. The search for causes of OGIB is usually centered on visualizing the small bowel, and in the past decade, the technology to visualize the entire small bowel has significantly advanced. Moreover, small bowel endoscopic imaging has replaced, in many instances, prior radiographic evaluation for obscure GI bleeding. These new modalities, such as small bowel capsule endoscopy (CE, balloon-assisted deep enteroscopy [double balloon enteroscopy (DBE and single balloon enteroscopy (SBE], and overtube-assisted deep enteroscopy (spiral enteroscopy, are paving the way toward more accurately identifying and treating patients with OGIB. We will review the diagnostic modalities available in evaluating a patient with OGIB and also propose the management based on clinical and endoscopic findings.

  11. MODEL PERENCANAAN KAPASITAS DI PT GI DIVISI FRAGRANCE

    Directory of Open Access Journals (Sweden)

    Sudrajat .

    2015-02-01

    Full Text Available This research focuses on MTO strategy in fragrance division of PT GI which has a number of workstations with multiple tools, resources and products profile. The aims are developing a mathematic model of capacity planning system and analyzing the maximum production capacity and flexibility of resources to meet demand. The method is using RCCP technique that consists of product-load profiles, bills of capacity and labors. Cluster technical of sampling and probability plot are used for measuring and analyzing the output of each process and validating the mathematic model of capacity plan in order to establish certain specific sources, especially those expected to be a potential barrier (potential bottleneck, is sufficient to cover the expected demand till one year ahead.

  12. Pengembangan SMS Gateway Layanan Informasi Akademik di STMIK GI MDP

    Directory of Open Access Journals (Sweden)

    Fransiska Prihatini Sihotang

    2017-08-01

    Full Text Available Information technology can be utilized in education such as e-Learning and Academic Information System. STMIK GI MDP has applied information technology that provides ease for the dissemination of academic information to students. However, the parents of the students have not obtained the academic information of their children due to the lack of internet-related knowledge. Therefore, this study aims to create a service that is able to convey information to parents directly with SMS Gateway service. This research begins with the collection of user needs through observation techniques and interviews to academic staff and parents. Then performed the required feature analysis. Then the design of SMS Gateway application that will be embedded in existing academic applications and coding system. Gammu is used as a link between applications with mobile phones. The result of this research is the application of SMS Gateway service that can give the student academic information to the parents.

  13. Increasing Active Student Responding in a University Applied Behavior Analysis Course: The Effect of Daily Assessment and Response Cards on End of Week Quiz Scores

    Science.gov (United States)

    Malanga, Paul R.; Sweeney, William J.

    2008-01-01

    The study compared the effects of daily assessment and response cards on average weekly quiz scores in an introduction to applied behavior analysis course. An alternating treatments design (Kazdin 1982, "Single-case research designs." New York: Oxford University Press; Cooper et al. 2007, "Applied behavior analysis." Upper Saddle River:…

  14. The Knowledge-about-Older-Patients - Quiz (KOP-Q) for nurses : Cross-cultural validation between the Netherlands and United States of America

    NARCIS (Netherlands)

    Dikken, Jeroen; Hoogerduijn, Jita G.; Klaassen, Sharon; Lagerwey, Mary D; Shortridge-Baggett, Lillie; Schuurmans, Marieke J.

    2017-01-01

    Background The Knowledge about Older Patients-Quiz (KOP-Q) is designed as a unidimensional scale measuring knowledge of hospital nurses about older patients. Furthermore, the KOP-Q measures a second unidimensional construct, certainty of hospital nurses about their knowledge. The KOP-Q is developed

  15. SAGES's advanced GI/MIS fellowship curriculum pilot project.

    Science.gov (United States)

    Weis, Joshua J; Goldblatt, Matthew; Pryor, Aurora; Dunkin, Brian J; Brunt, L Michael; Jones, Daniel B; Scott, Daniel J

    2018-06-01

    The American health care system faces deficits in quality and quantity of surgeons. SAGES is a major stakeholder in surgical fellowship training and is responsible for defining the curriculum for the Advanced GI/MIS fellowship. SAGES leadership is actively adapting this curriculum. The process of reform began in 2014 through a series of iterative meetings and discussions. A working group within the Resident and Fellow Training Committee reviewed case log data from 2012 to 2015. These data were used to propose new criteria designed to provide adequate exposure to core content. The working group also proposed using video assessment of an MIS case to provide objective assessment of competency. Case log data were available for 326 fellows with a total of 85,154 cases logged (median 227 per fellow). The working group proposed new criteria starting with minimum case volumes for five defined categories including foregut (20), bariatrics (25), inguinal hernia (10), ventral hernia (10), and solid organ/colon/thoracic (10). Fellows are expected to perform an additional 75 complex MIS cases of any category for a total of 150 required cases overall. The proposal also included a minimum volume of flexible endoscopy (50) and submission of an MIS foregut case for video assessment. The new criteria more clearly defined which surgeon roles count for major credit within individual categories. Fourteen fellowships volunteered to pilot these new criteria for the 2017-2018 academic year. The new SAGES Advanced GI/MIS fellowship has been crafted to better define the core content that should be contained in these fellowships, while still allowing sufficient heterogeneity so that individual learners can tailor their training to specific areas of interest. The criteria also introduce innovative, evidence-based methods for assessing competency. Pending the results of the pilot program, SAGES will consider broad implementation of the new fellowship criteria.

  16. The Role of "Family Snapshots" in Teaching Art History within a Dialogic Pedagogy

    Science.gov (United States)

    Baxter, Kristin

    2012-01-01

    Studying images of families in works of art and in snapshots is compelling, and the author wondered if looking at both types of images side by side might help students understand both kinds of images more fully. Snapshots often prompt detailed and vivid stories among family members and friends. Therefore, she wondered if dialogue about snapshots…

  17. Pressure estimation from single-snapshot tomographic PIV in a turbulent boundary layer

    NARCIS (Netherlands)

    Schneiders, J.F.G.; Pröbsting, S.; Dwight, R.P.; Van Oudheusden, B.W.; Scarano, F.

    2016-01-01

    A method is proposed to determine the instantaneous pressure field from a single tomographic PIV velocity snapshot and is applied to a flat-plate turbulent boundary layer. The main concept behind the single-snapshot pressure evaluation method is to approximate the flow acceleration using the

  18. A Snapshot-Based Mechanism for Celestial Orientation.

    Science.gov (United States)

    El Jundi, Basil; Foster, James J; Khaldy, Lana; Byrne, Marcus J; Dacke, Marie; Baird, Emily

    2016-06-06

    In order to protect their food from competitors, ball-rolling dung beetles detach a piece of dung from a pile, shape it into a ball, and roll it away along a straight path [1]. They appear to rely exclusively on celestial compass cues to maintain their bearing [2-8], but the mechanism that enables them to use these cues for orientation remains unknown. Here, we describe the orientation strategy that allows dung beetles to use celestial cues in a dynamic fashion. We tested the underlying orientation mechanism by presenting beetles with a combination of simulated celestial cues (sun, polarized light, and spectral cues). We show that these animals do not rely on an innate prediction of the natural geographical relationship between celestial cues, as other navigating insects seem to [9, 10]. Instead, they appear to form an internal representation of the prevailing celestial scene, a "celestial snapshot," even if that scene represents a physical impossibility for the real sky. We also find that the beetles are able to maintain their bearing with respect to the presented cues only if the cues are visible when the snapshot is taken. This happens during the "dance," a behavior in which the beetle climbs on top of its ball and rotates about its vertical axis [11]. This strategy for reading celestial signals is a simple but efficient mechanism for straight-line orientation. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. Snapshot imaging Fraunhofer line discriminator for detection of plant fluorescence

    Science.gov (United States)

    Gupta Roy, S.; Kudenov, M. W.

    2015-05-01

    Non-invasive quantification of plant health is traditionally accomplished using reflectance based metrics, such as the normalized difference vegetative index (NDVI). However, measuring plant fluorescence (both active and passive) to determine photochemistry of plants has gained importance. Due to better cost efficiency, lower power requirements, and simpler scanning synchronization, detecting passive fluorescence is preferred over active fluorescence. In this paper, we propose a high speed imaging approach for measuring passive plant fluorescence, within the hydrogen alpha Fraunhofer line at ~656 nm, using a Snapshot Imaging Fraunhofer Line Discriminator (SIFOLD). For the first time, the advantage of snapshot imaging for high throughput Fraunhofer Line Discrimination (FLD) is cultivated by our system, which is based on a multiple-image Fourier transform spectrometer and a spatial heterodyne interferometer (SHI). The SHI is a Sagnac interferometer, which is dispersion compensated using blazed diffraction gratings. We present data and techniques for calibrating the SIFOLD to any particular wavelength. This technique can be applied to quantify plant fluorescence at low cost and reduced complexity of data collection.

  20. #Frailty: A snapshot Twitter report on frailty knowledge translation.

    Science.gov (United States)

    Jha, Sunita R; McDonagh, Julee; Prichard, Ros; Newton, Phillip J; Hickman, Louise D; Fung, Erik; Macdonald, Peter S; Ferguson, Caleb

    2018-05-07

    The objectives of this short report are to: (i) explore #Frailty Twitter activity over a six-month period; and (ii) provide a snapshot Twitter content analysis of #Frailty usage. A mixed-method study was conducted to explore Twitter data related to frailty. The primary search term was #Frailty. Objective 1: data were collected using Symplur analytics, including variables for total number of tweets, unique tweeters (users) and total number of impressions. Objective 2: a retrospectively conducted snapshot content analysis of 1500 #Frailty tweets was performed using TweetReach ™ . Over a six-month period (1 January 2017-31 June 2017), there was a total of 6545 #Frailty tweets, generating 14.8 million impressions across 3986 participants. Of the 1500 tweets (814 retweets; 202 replies; 484 original tweets), 56% were relevant to clinical frailty. The main contributors ('who') were as follows: the public (29%), researchers (25%), doctors (21%), organisations (18%) and other allied health professionals (7%). Tweet main message intention ('what') was public health/advocacy (41%), social communication (28%), research-based evidence/professional education (24%), professional opinion/case studies (15%) and general news/events (7%). Twitter is increasingly being used to communicate about frailty. It is important that thought leaders contribute to the conversation. There is potential to leverage Twitter to promote and disseminate frailty-related knowledge and research. © 2018 AJA Inc.

  1. A snapshot attractor view of the advection of inertial particles in the presence of history force

    Science.gov (United States)

    Guseva, Ksenia; Daitche, Anton; Tél, Tamás

    2017-06-01

    We analyse the effect of the Basset history force on the sedimentation or rising of inertial particles in a two-dimensional convection flow. We find that the concept of snapshot attractors is useful to understand the extraordinary slow convergence due to long-term memory: an ensemble of particles converges exponentially fast towards a snapshot attractor, and this attractor undergoes a slow drift for long times. We demonstrate for the case of a periodic attractor that the drift of the snapshot attractor can be well characterized both in the space of the fluid and in the velocity space. For the case of quasiperiodic and chaotic dynamics we propose the use of the average settling velocity of the ensemble as a distinctive measure to characterize the snapshot attractor and the time scale separation corresponding to the convergence towards the snapshot attractor and its own slow dynamics.

  2. Transcription of gD and gI genes in BHV1-infected cells

    Indian Academy of Sciences (India)

    ) are contiguous genes with 141 bp region between the two open reading frames (ORFs). Expression of gD and gI from a bicistronic construct containing complete gD and gI gene has been reported either through internal ribosome entry site ...

  3. Mari Rahumägi kui särav piksevarras / Katri Soe

    Index Scriptorium Estoniae

    Soe, Katri

    2006-01-01

    Euroopa suurima postimüügi kontserni Karstadt-Quelle Eesti tütarfirma tegevjuhi karjäärist, oma äri alustamisest ja siirdumisest palgatööle. Kommenteerivad Jaanus Rahumägi, Helina Tuuna, Matthias Fink

  4. SMV1, an extremely stable thermophilic virus platform for nanoparticle trafficking in the mammalian GI tract

    DEFF Research Database (Denmark)

    Uldahl, Kristine Buch; Walk, S. T.; Olshefsky, S. C.

    2017-01-01

    undetectable inflammatory response. Finally, we used human intestinal organoids (HIOs) to show that labelled SMV1 did not invade or otherwise perturb the human GI tract epithelium. Conclusion: Sulfolobus monocaudavirus 1 appeared stable and safe during passage though the mammalian GI tract. Significance...

  5. Prügi tekkekohas sortimise kavatsus on läbi kukkunud / Anti Ronk

    Index Scriptorium Estoniae

    Ronk, Anti

    2004-01-01

    Korteriühistute ja prügifirmade kogemuste kohaselt ei ole Eesti inimesed harjunud prügi sorteerima ega kasuta vastavaid konteinereid. Kommentaarid Lauka korteriühistu eksjuhilt Nelli Vahemetsalt ja Ragn-Sellsi müügijuhilt Maren Pärnalt. Lisa: Prügi

  6. Transcriptional Analyses of Barrett's Metaplasia and Normal Upper GI Mucosae

    Directory of Open Access Journals (Sweden)

    Michael T. Barrett

    2002-01-01

    Full Text Available Over the last two decades, the incidence of esophageal adenocarcinoma (EA has increased dramatically in the US and Western Europe. It has been shown that EAs evolve from premalignant Barrett's esophagus (BE tissue by a process of clonal expansion and evolution. However, the molecular phenotype of the premalignant metaplasia, and its relationship to those of the normal upper gastrointestinal (GI mucosae, including gastric, duodenal, and squamous epithelium of the esophagus, has not been systematically characterized. Therefore, we used oligonucleotide-based microarrays to characterize gene expression profiles in each of these tissues. The similarity of BE to each of the normal tissues was compared using a series of computational approaches. Our analyses included esophageal squamous epithelium, which is present at the same anatomic site and exposed to similar conditions as Barrett's epithelium, duodenum that shares morphologic similarity to Barrett's epithelium, and adjacent gastric epithelium. There was a clear distinction among the expression profiles of gastric, duodenal, and squamous epithelium whereas the BE profiles showed considerable overlap with normal tissues. Furthermore, we identified clusters of genes that are specific to each of the tissues, to the Barrett's metaplastic epithelia, and a cluster of genes that was distinct between squamous and nonsquamous epithelia.

  7. Radiological evaluation of G-I tract diverticulum in Korean

    International Nuclear Information System (INIS)

    Sung, Ki Jun; Park, Joong Wha; Hong, In Soo; Kim, Myung Soon

    1986-01-01

    We reviewed 887 cases of esophagogram, 8863 cases of UGI series, 174 cases of small bowel series and 1926 cases of double contrast barium enema performed at the department of Radiology, Wonju College of Medicine from Jan. 1982 to Dec. 1984 to analyzed diverticular disease pattern of the GI tract in Korean. The results were as follows: 1. Esophageal diverticular. The incidence was 3.27% and the sex ratio of male to female was 2.22:1 Age distribution was relatively even and most common in 5th decade. Most of them showed single in number, above 6mm sized and common in middle one third of both lateral side of esophagus. 2. Stomach diverticular. The incidence was 0.07% and the sex ratio of male to female was equal. Multiplicity was single in all cases. Most of them were above 11mm sized and common in gastric fundic area of greater curvature site of stomach. 3. Duodenal diverticular. The incidence was 1.51% and relatively even distribution in sex and age and common in after 5th decade. Most of them showed single in number, 11-30mm sized and common in medial margin of 2nd portion of duodenum. 4. Colonic diverticular. The incidence was 2.34% and predominant in male and common in 5th. and 6th. decade. Most of them showed single in number, below 5mm sized and common in right sided colon.

  8. Radiological evaluation of G-I tract diverticulum in Korean

    Energy Technology Data Exchange (ETDEWEB)

    Sung, Ki Jun; Park, Joong Wha; Hong, In Soo; Kim, Myung Soon [Yeonsei University Wonju College of Medicine, Wonju (Korea, Republic of)

    1986-12-15

    We reviewed 887 cases of esophagogram, 8863 cases of UGI series, 174 cases of small bowel series and 1926 cases of double contrast barium enema performed at the department of Radiology, Wonju College of Medicine from Jan. 1982 to Dec. 1984 to analyzed diverticular disease pattern of the GI tract in Korean. The results were as follows: 1. Esophageal diverticular. The incidence was 3.27% and the sex ratio of male to female was 2.22:1 Age distribution was relatively even and most common in 5th decade. Most of them showed single in number, above 6mm sized and common in middle one third of both lateral side of esophagus. 2. Stomach diverticular. The incidence was 0.07% and the sex ratio of male to female was equal. Multiplicity was single in all cases. Most of them were above 11mm sized and common in gastric fundic area of greater curvature site of stomach. 3. Duodenal diverticular. The incidence was 1.51% and relatively even distribution in sex and age and common in after 5th decade. Most of them showed single in number, 11-30mm sized and common in medial margin of 2nd portion of duodenum. 4. Colonic diverticular. The incidence was 2.34% and predominant in male and common in 5th. and 6th. decade. Most of them showed single in number, below 5mm sized and common in right sided colon.

  9. A Distributed Snapshot Protocol for Efficient Artificial Intelligence Computation in Cloud Computing Environments

    Directory of Open Access Journals (Sweden)

    JongBeom Lim

    2018-01-01

    Full Text Available Many artificial intelligence applications often require a huge amount of computing resources. As a result, cloud computing adoption rates are increasing in the artificial intelligence field. To support the demand for artificial intelligence applications and guarantee the service level agreement, cloud computing should provide not only computing resources but also fundamental mechanisms for efficient computing. In this regard, a snapshot protocol has been used to create a consistent snapshot of the global state in cloud computing environments. However, the existing snapshot protocols are not optimized in the context of artificial intelligence applications, where large-scale iterative computation is the norm. In this paper, we present a distributed snapshot protocol for efficient artificial intelligence computation in cloud computing environments. The proposed snapshot protocol is based on a distributed algorithm to run interconnected multiple nodes in a scalable fashion. Our snapshot protocol is able to deal with artificial intelligence applications, in which a large number of computing nodes are running. We reveal that our distributed snapshot protocol guarantees the correctness, safety, and liveness conditions.

  10. Snapshots of the Universe: A Multilingual Astronomy Book

    Science.gov (United States)

    Beaton, R. L.; Sokal, K. R.; Liss, S. E.; Johnson, K. E.

    2015-11-01

    Dark Skies, Bright Kids! (DSBK) is an outreach organization at the University of Virginia, focused on enhancing elementary level science education in under-served communities. Early in the program, DSBK volunteers encountered difficulties connecting with English as a second language (ESL) students. To meet that challenge, DSBK volunteers created story-book style art with short descriptions of astronomical objects in both Spanish and English to help communicate basic astronomy concepts to these students. Building on this initial success, our simple project has evolved into a full multilingual children's book targeted at 2nd-5th grade students. Though originally in Spanish and English, a partnership with the University of Alberta (Canada) has produced a French translation of the text, broadening the outreach potential of the book. In this contribution, we describe Snapshots of the Universe (Instantáneas del Universo) and reflect upon the process of creating this unique resource.

  11. Double-gated spectral snapshots for biomolecular fluorescence

    International Nuclear Information System (INIS)

    Nakamura, Ryosuke; Hamada, Norio; Ichida, Hideki; Tokunaga, Fumio; Kanematsu, Yasuo

    2007-01-01

    A versatile method to take femtosecond spectral snapshots of fluorescence has been developed based on a double gating technique in the combination of an optical Kerr gate and an image intensifier as an electrically driven gate set in front of a charge-coupled device detector. The application of a conventional optical-Kerr-gate method is limited to molecules with the short fluorescence lifetime up to a few hundred picoseconds, because long-lifetime fluorescence itself behaves as a source of the background signal due to insufficiency of the extinction ratio of polarizers employed for the Kerr gate. By using the image intensifier with the gate time of 200 ps, we have successfully suppressed the background signal and overcome the application limit of optical-Kerr-gate method. The system performance has been demonstrated by measuring time-resolved fluorescence spectra for laser dye solution and the riboflavin solution as a typical sample of biomolecule

  12. Advanced GI Surgery Training-a Roadmap for the Future: the White Paper from the SSAT Task Force on Advanced GI Surgery Training.

    Science.gov (United States)

    Hutter, Matthew M; Behrns, Kevin E; Soper, Nathaniel J; Michelassi, Fabrizio

    2017-04-01

    There is the need for well-trained advanced GI surgeons. The super specialization seen in academic and large community centers may not be applicable for surgeons practicing in other settings. The pendulum that has been swinging toward narrow specialization is swinging the other way, as many trained subspecialists are having a harder time finding positions after fellowship, and if they do find a position, the majority of their practice can actually be advanced GI surgery and not exclusively their area of focused expertise. Many hospitals/practices desire surgeons who are competent and specifically credentialed to perform a variety of advanced GI procedures from the esophagus through the anus. Furthermore, broader exposure in training may provide complementary and overlapping skills that may lead to an even better trained GI surgeon compared to someone whose experience is limited to just the liver and pancreas, or to just the colon and rectum, or to only bariatric and foregut surgery. With work hour restrictions and limitations on autonomy for current trainees in residency, many senior trainees have not developed the skills and knowledge to allow them to be competent and comfortable in the broad range of GI surgery. Such training should reflect the needs of the patients and their diseases, and reflect what many practicing surgeons are currently doing, and what many trainees say they would like to do, if there were such fellowship pathways available to them. The goal is to train advanced GI surgeons who are competent and proficient to operate throughout the GI tract and abdomen with open, laparoscopic, and endoscopic techniques in acute and elective situations in a broad variety of complex GI diseases. The program may be standalone, or prepare a surgeon for additional subspecialty training (transition to fellowship and/or to practice). This group of surgeons should be distinguished from subspecialist surgeons who focus in a narrow area of GI surgery. Advanced GI

  13. What do students do when asked to diagnose their mistakes? Does it help them? II. A more typical quiz context

    Directory of Open Access Journals (Sweden)

    Edit Yerushalmi

    2012-09-01

    Full Text Available “Self-diagnosis tasks” aim at fostering students’ learning in an examination context by requiring students to present diagnoses of their solutions to quiz problems. We examined the relationship between students’ learning from self-diagnosis and the typicality of the problem situation. Four recitation groups in an introductory physics class (∼200 students were divided into a control group and three intervention groups in which different levels of guidance were provided to aid students in their performance of self-diagnosis activities. The self-diagnosis task was administered twice, first in an atypical problem situation and then in a typical one. In a companion paper we reported our findings in the context of an atypical problem situation. Here we report our findings in the context of a typical problem situation and discuss the effect of problem typicality on students’ self-diagnosis performance and subsequent success in solving transfer problems. We show that the self-diagnosis score was correlated with subsequent problem-solving performance only in the context of a typical problem situation, and only when textbooks and notebooks were the sole means of guidance available to the students for assisting them with diagnosis.

  14. Teaching baroreflex physiology to medical students: a comparison of quiz-based and conventional teaching strategies in a laboratory exercise.

    Science.gov (United States)

    Berg, Ronan M G; Plovsing, Ronni R; Damgaard, Morten

    2012-06-01

    Quiz-based and collaborative teaching strategies have previously been found to be efficient for the improving meaningful learning of physiology during lectures. These approaches have, however, not been investigated during laboratory exercises. In the present study, we compared the impact of solving quizzes individually and in groups with conventional teaching on the immediate learning during a laboratory exercise. We implemented two quizzes in a mandatory 4-h laboratory exercise on baroreflex physiology. A total of 155 second-year medical students were randomized to solve quizzes individually (intervention group I, n = 57), in groups of three to four students (intervention group II, n = 56), or not to perform any quizzes (control; intervention group III, n = 42). After the laboratory exercise, all students completed an individual test, which encompassed two recall questions, two intermediate questions, and two integrated questions. The integrated questions were of moderate and advanced difficulty, respectively. Finally, students completed an evaluation form. Intervention group I reached the highest total test scores and proved best at answering the integrated question of advanced difficulty. Moreover, there was an overall difference between groups for student evaluations of the quality of the teaching, which was highest for intervention group II. In conclusion, solving quizzes individually during a laboratory exercise may enhance learning, whereas solving quizzes in groups is associated with higher student satisfaction.

  15. Anti-metallothionein IgG and levels of metallothionein in autistic children with GI disease

    Directory of Open Access Journals (Sweden)

    A J Russo

    2009-01-01

    Full Text Available A J RussoMount Saint Mary’s University, Emmitsburg, MD, USAAim: To assess both serum concentration of metallotionein (MT and anti-metallothionein (anti-MT immunoglobulin G (IgG in autistic children with gastrointestinal (GI symptoms and controls, and to test the hypothesis that there is an association between the presence of MT, anti-MT IgG, and inflammatory GI disease seen in many children with autistic spectrum disorder (ASD.Subjects and methods: ELISAs were used to measure serum MT and anti-MT IgG in 41 autistic children with chronic digestive disease (many with ileo-colonic lymphoid nodular hyperplasia [LNH] and inflammation of the colorectum, small bowel, and/or stomach, and 33 controls (17 age-matched autistic children with no GI disease and 16 age-matched children without autism or GI disease.Results: Ten of 41 autistic children with chronic digestive disease had high serum concentration of MT compared to only one of the 33 controls (p < 0.01. Thirteen of the 41 autistic children with chronic digestive disease had anti-MT IgG compared to only four of 33 controls (p < 0.01. Nine of 10 (90% of autistic children with GI disease with high MT levels had a regressive onset (compared to the expected 25 of 41, or 61%, in this group (p < 0.05, whereas only nine of 13 of the autistic children with GI disease and anti-MT IgG had a regressive onset (70% which was not significantly higher than the expected. We didn’t find any correlation between severity of GI disease and MT concentration or anti-MT IgG.Discussion: These results suggest a relationship between MT, anti-MT IgG and GI disease seen in many ASD individuals.Keywords: autism, metallothionein, anti-metallothionein, GI disease

  16. Can social policy influence socioeconomic disparities? Korean War GI Bill eligibility and markers of depression.

    Science.gov (United States)

    Vable, Anusha M; Canning, David; Glymour, M Maria; Kawachi, Ichiro; Jimenez, Marcia P; Subramanian, Subu V

    2016-02-01

    The Korean War GI Bill provided socioeconomic benefits to veterans; however, its association with health is unclear; we hypothesize GI Bill eligibility is associated with fewer depressive symptoms and smaller disparities. Data from 246 Korean War GI Bill eligible veterans and 240 nonveterans from the Health and Retirement Study were matched on birth year, southern birth, race, height, and childhood health using coarsened exact matching. Number of depressive symptoms in 2010 (average age = 78 years) was assessed using a modified, validated Center for Epidemiologic Studies-Depression Scale, dichotomized to reflect elevated depressive symptoms. Regression analyses were stratified into low (at least one parent markers. Copyright © 2016 Elsevier Inc. All rights reserved.

  17. Energy Transition Initiative: Island Energy Snapshot - Puerto Rico (Fact Sheet); NREL(National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-03-01

    This profile provides a snapshot of the energy landscape of the Commonwealth of Puerto Rico - a U.S. territory located about 60 miles east of the Dominican Republic and directly west of the U.S. Virgin Islands.

  18. Energy Transition Initiative, Island Energy Snapshot - British Virgin Islands (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    2015-03-01

    This profile provides a snapshot of the energy landscape of the British Virgin Islands (BVI), one of three sets of the Virgin Island territories in an archipelago making up the northern portion of the Lesser Antilles.

  19. Energy Transition Initiative: Island Energy Snapshot - Saint Martin/Sint Maarten

    Energy Technology Data Exchange (ETDEWEB)

    2015-09-01

    This profile provides a snapshot of the energy landscape of the northeast Caribbean island Saint Martin. The island is divided between two nations, France in the north (Saint-Martin) and the Netherlands in the south (Sint Maarten).

  20. A Data Snapshot Approach for Making Real-Time Predictions in Basketball.

    Science.gov (United States)

    Kayhan, Varol Onur; Watkins, Alison

    2018-06-08

    This article proposes a novel approach, called data snapshots, to generate real-time probabilities of winning for National Basketball Association (NBA) teams while games are being played. The approach takes a snapshot from a live game, identifies historical games that have the same snapshot, and uses the outcomes of these games to calculate the winning probabilities of the teams in this game as the game is underway. Using data obtained from 20 seasons worth of NBA games, we build three models and compare their accuracies to a baseline accuracy. In Model 1, each snapshot includes the point difference between the home and away teams at a given second of the game. In Model 2, each snapshot includes the net team strength in addition to the point difference at a given second. In Model 3, each snapshot includes the rate of score change in addition to the point difference at a given second. The results show that all models perform better than the baseline accuracy, with Model 1 being the best model.

  1. "Nizkii reiting - eto problema" / Taavi Veskimägi ; interv. Tatjana Opekina

    Index Scriptorium Estoniae

    Veskimägi, Taavi, 1974-

    2006-01-01

    Res Publica liidri Taavi Veskimägi suhtumisest president Arnold Rüütli võimalikku jätkamisse, hinnangutest tuntud poliitikute lahkumisele Res Publicast, ühenduse kujunemisest parteiks, partei reitingust, valitseva koalitsiooni kriitika

  2. Kalevi juhtfiguur Priimägi lõi ajalehti kirjastava firma / Toivo Tänavsuu

    Index Scriptorium Estoniae

    Tänavsuu, Toivo

    2007-01-01

    Kalevi nõukogu liige Heino Priimägi on ajalehtede ja ajakirjade kirjastamisega tegeleva firma Complus Solutions juhatuse liige. Kalevi pressiesindaja Aire Milli väitel ei ole Complus Solutions Kaleviga seotud firma

  3. Late GI and GU complications in the treatment of prostate cancer

    International Nuclear Information System (INIS)

    Schultheiss, Timothy E.; Lee, W. Robert; Hunt, Margie A.; Hanlon, Alexandra L.; Peter, Ruth S.; Hanks, Gerald E.

    1997-01-01

    Purpose: To assess the factors that predict late GI and GU morbidity in radiation treatment of the prostate. Methods and Materials: Seven hundred twelve consecutive prostate cancer patients treated at this institution between 1986 and 1994 (inclusive) with conformal or conventional techniques were included in the analysis. Patients had at least 3 months follow-up and received at least 65 Gy. Late GI Grade 3 morbidity was rectal bleeding (requiring three or more procedure) or proctitis. Late Grade 3 GU morbidity was cystitis or structure. Multivariate analysis (MVA) was used to assess factors related to the complication-free survival. The factors assessed were age, occurrence of side effects ≥ Grade 2 during treatment, irradiated volume parameters (use of pelvic fields, treatment of seminal vesicles to full dose or 57 Gy, and use of additional rectal shielding), dose, comorbidities, and other treatments (hormonal manipulation, TURP). Results: Acute GI and GU side effects (Grade 2 or higher ) were noted in 246 and 201 patients, respectively; 67 of these patients exhibited both. GI side effects were not correlated with GU side effects acutely. Late and acute morbidities were correlated (both GI and GU). Fifteen of the 712 patients expressed Grade 3 or 4 GI injuries 3 to 32 months after the end of treatment, with a mean of 14.3 months. One hundred fifteen patients expressed Grade 2 or higher GI morbidity (mean: 13.7 months). The 43 Grade 2 or higher GU morbidities occurred significantly later (mean: 22.7 months). Central axis dose was the only independent variable significantly related to the incidence of late GI morbidity on MVA. No treatment volume parameters were significant for Grade 3. The following parameters were significantly related (by MVA) to Grade 2 GI morbidity: central axis dose, use of the increased rectal shielding, androgen deprivation therapy starting before RT. Acute and late GI morbidities were highly correlated. History of diabetes, treatment of

  4. Standardi juhid maksid 37, 5 miljonit krooni / Aivar Hundimägi

    Index Scriptorium Estoniae

    Hundimägi, Aivar, 1975-

    2004-01-01

    Standardi juhatuse esimees Enn Veskimägi ning juhatuse liikmed Priit Tamm ja Mati Peekma omandasid 58% Standardi aktsiatest, makstes Indoor Group'ile ja riskikapitaliinvestorile BaltCap tehingu eest väidetavalt 37, 5 miljonit krooni

  5. Kaks musketäri. 20 aastat hiljem / Tristan Priimägi

    Index Scriptorium Estoniae

    Priimägi, Tristan, 1976-

    2007-01-01

    Tristan Priimägi kohtumisest Londoni klubis Hard Rock Cafe ameerika rockansambli Aerosmith liikmetega, intervjuu Steven Tyleriga. Heliplaatidest "Aerosmith", "Toys in the Attic", Run D.M.C & Aerosmith "Walk This Way", Get a Grip"

  6. Benzimidazole derivatives: search for GI-friendly anti-inflammatory analgesic agents

    Directory of Open Access Journals (Sweden)

    Monika Gaba

    2015-07-01

    Full Text Available Non-steroidal anti-inflammatory drugs (NSAIDs have been successfully used for the alleviation of pain and inflammation in the past and continue to be used daily by millions of patients worldwide. However, gastrointestinal (GI toxicity associated with NSAIDs is an important medical and socioeconomic problem. Local generation of various reactive oxygen species plays a significant role in the formation of gastric ulceration associated with NSAIDs therapy. Co-medication of antioxidants along with NSAIDs has been found to be beneficial in the prevention of GI injury. This paper describes the synthesis and biological evaluation of N-1-(phenylsulfonyl-2-methylamino-substituted-1H-benzimidazole derivatives as anti-inflammatory analgesic agents with lower GI toxicity. Studies in vitro and in vivo demonstrated that the antioxidant activity of the test compounds decreased GI toxicity.

  7. [Recurrent epidemics of gastroenteritis caused by norovirus GI.3 in a small hotel].

    Science.gov (United States)

    Soini, Jani; Hemminki, Kaisa; Pirnes, Aija; Roivainen, Merja; Al-Hello, Haider; Maunula, Leena; Kauppinen, Ari; Miettinen, Likka; Smit, Pieter W; Huusko, Sari; Toikkanen, Salla; Rimhanen-Finne, Ruska

    2016-01-01

    Recurrent cases of gastroenteritis occurred in a small hotel. The causative agent of disease could not be detected. The cause and the source of the disease were established through epidemiological investigations and laboratory diagnosis. The causative agent of the disease was norovirus GI.3. Norovirus GI was detected in the water from the well and on surfaces at the hotel. Both epidemiological investigations and laboratory diagnostics are needed in resolving epidemics. Continuous development of laboratory methods is important.

  8. Single-snapshot DOA estimation by using Compressed Sensing

    Science.gov (United States)

    Fortunati, Stefano; Grasso, Raffaele; Gini, Fulvio; Greco, Maria S.; LePage, Kevin

    2014-12-01

    This paper deals with the problem of estimating the directions of arrival (DOA) of multiple source signals from a single observation vector of an array data. In particular, four estimation algorithms based on the theory of compressed sensing (CS), i.e., the classical ℓ 1 minimization (or Least Absolute Shrinkage and Selection Operator, LASSO), the fast smooth ℓ 0 minimization, and the Sparse Iterative Covariance-Based Estimator, SPICE and the Iterative Adaptive Approach for Amplitude and Phase Estimation, IAA-APES algorithms, are analyzed, and their statistical properties are investigated and compared with the classical Fourier beamformer (FB) in different simulated scenarios. We show that unlike the classical FB, a CS-based beamformer (CSB) has some desirable properties typical of the adaptive algorithms (e.g., Capon and MUSIC) even in the single snapshot case. Particular attention is devoted to the super-resolution property. Theoretical arguments and simulation analysis provide evidence that a CS-based beamformer can achieve resolution beyond the classical Rayleigh limit. Finally, the theoretical findings are validated by processing a real sonar dataset.

  9. Capturing Snapshots of APE1 Processing DNA Damage

    Science.gov (United States)

    Freudenthal, Bret D.; Beard, William A.; Cuneo, Matthew J.; Dyrkheeva, Nadezhda S.; Wilson, Samuel H.

    2015-01-01

    DNA apurinic-apyrimidinic (AP) sites are prevalent non-coding threats to genomic stability and are processed by AP endonuclease 1 (APE1). APE1 incises the AP-site phosphodiester backbone, generating a DNA repair intermediate that is potentially cytotoxic. The molecular events of the incision reaction remain elusive due in part to limited structural information. We report multiple high-resolution human APE1:DNA structures that divulge novel features of the APE1 reaction, including the metal binding site, nucleophile, and arginine clamps that mediate product release. We also report APE1:DNA structures with a T:G mismatch 5′ to the AP-site, representing a clustered lesion occurring in methylated CpG dinucleotides. These reveal that APE1 molds the T:G mismatch into a unique Watson-Crick like geometry that distorts the active site reducing incision. These snapshots provide mechanistic clarity for APE1, while affording a rational framework to manipulate biological responses to DNA damage. PMID:26458045

  10. A Snapshot View of High Temperature Superconductivity 2002

    Energy Technology Data Exchange (ETDEWEB)

    Schuller, Ivan K. [Univ. of California, San Diego, CA (United States); Bansil, Arun [Northeastern Univ., Boston, MA (United States); Basov, Dimitri N. [Univ. of California, San Diego, CA (United States)

    2002-04-05

    This report outlines the conclusions of a workshop on High Temperature Superconductivity held April 5-8, 2002 in San Diego. The purpose of this report is to outline and highlight some outstanding and interesting issues in the field of High Temperature Superconductivity. The range of activities and new ideas that arose within the context of High Temperature Superconductors is so vast and extensive that it is impossible to summarize it in a brief document. Thus, this report does not pretend to be all-inclusive and cover all areas of activity. It is a restricted snapshot and it only presents a few viewpoints. The complexity and difficulties with high temperature superconductivity are well illustrated by the Buddhist parable of the blind men trying to describe “experimentally” an elephant. These very same facts clearly illustrate that this is an extremely active field, with many unanswered questions, and with a great future potential for discoveries and progress in many (sometimes unpredictable) directions. It is very important to stress that, independently of any current or future applications, this is a very important area of basic research.

  11. The Snapshot A Star SurveY (SASSY)

    Science.gov (United States)

    Garani, Jasmine I.; Nielsen, Eric; Marchis, Franck; Liu, Michael C.; Macintosh, Bruce; Rajan, Abhijith; De Rosa, Robert J.; Jinfei Wang, Jason; Esposito, Thomas M.; Best, William M. J.; Bowler, Brendan; Dupuy, Trent; Ruffio, Jean-Baptiste

    2018-01-01

    The Snapshot A Star Survey (SASSY) is an adaptive optics survey conducted using NIRC2 on the Keck II telescope to search for young, self-luminous planets and brown dwarfs (M > 5MJup) around high mass stars (M > 1.5 M⊙). We present the results of a custom data reduction pipeline developed for the coronagraphic observations of our 200 target stars. Our data analysis method includes basic near infrared data processing (flat-field correction, bad pixel removal, distortion correction) as well as performing PSF subtraction through a Reference Differential Imaging algorithm based on a library of PSFs derived from the observations using the pyKLIP routine. We present the results from the pipeline of a few stars from the survey with analysis of candidate companions. SASSY is sensitive to companions 600,000 times fainter than the host star withint the inner few arcseconds, allowing us to detect companions with masses ~8MJup at age 110 Myr. This work was supported by the Leadership Alliance's Summer Research Early Identification Program at Stanford University, the NSF REU program at the SETI Institute and NASA grant NNX14AJ80G.

  12. A Snapshot of the Emerging Tomato Genome Sequence

    Directory of Open Access Journals (Sweden)

    Lukas A. Mueller

    2009-03-01

    Full Text Available The genome of tomato ( L. is being sequenced by an international consortium of 10 countries (Korea, China, the United Kingdom, India, the Netherlands, France, Japan, Spain, Italy, and the United States as part of the larger “International Solanaceae Genome Project (SOL: Systems Approach to Diversity and Adaptation” initiative. The tomato genome sequencing project uses an ordered bacterial artificial chromosome (BAC approach to generate a high-quality tomato euchromatic genome sequence for use as a reference genome for the Solanaceae and euasterids. Sequence is deposited at GenBank and at the SOL Genomics Network (SGN. Currently, there are around 1000 BACs finished or in progress, representing more than a third of the projected euchromatic portion of the genome. An annotation effort is also underway by the International Tomato Annotation Group. The expected number of genes in the euchromatin is ∼40,000, based on an estimate from a preliminary annotation of 11% of finished sequence. Here, we present this first snapshot of the emerging tomato genome and its annotation, a short comparison with potato ( L. sequence data, and the tools available for the researchers to exploit this new resource are also presented. In the future, whole-genome shotgun techniques will be combined with the BAC-by-BAC approach to cover the entire tomato genome. The high-quality reference euchromatic tomato sequence is expected to be near completion by 2010.

  13. The tenebrionidae of california: a time sensitive snapshot assessment.

    Science.gov (United States)

    Aalbu, Rolf L; Smith, Aaron D

    2014-01-01

    DUE TO A DIVERSITY OF HABITATS AND ITS GEOLOGIC HISTORY, THE US STATE OF CALIFORNIA HOSTS A SPECTACULAR ASSEMBLAGE OF DARKLING BEETLE SPECIES (COLEOPTERA: Tenebrionidae). In addition to being part of the California Floristic Province, one of 34 global biodiversity hotspots identified by Conservation International, California also has additional areas which are parts of the Great Basin, Mojave, and Sonoran deserts. California is divided into nine floristic regions. Each region is assessed in terms of faunal composition and endemism. A "snapshot" of our present knowledge of the Tenebrionidae indicates that 447 currently recognized species, representing 108 genera, occur in California of which one hundred and ninety are endemic. California is compared to other nearby regions in diversity and endemism. An analysis of currently valid species vs a more realistic species account based on unpublished records of likely synonyms and known species yet to be described in the scientific literature is presented. The California Floristic Region, rather than other more arid parts of California, has the highest number of total and endemic species. Because of their high diversity and endemism, tenebrionids could potentially provide a valuable tool for monitoring the environment for conservation purposes.

  14. A Snapshot View of High Temperature Superconductivity 2002

    International Nuclear Information System (INIS)

    Schuller, Ivan K.; Bansil, Arun; Basov, Dimitri N.

    2002-01-01

    This report outlines the conclusions of a workshop on High Temperature Superconductivity held April 5-8, 2002 in San Diego. The purpose of this report is to outline and highlight some outstanding and interesting issues in the field of High Temperature Superconductivity. The range of activities and new ideas that arose within the context of High Temperature Superconductors is so vast and extensive that it is impossible to summarize it in a brief document. Thus, this report does not pretend to be all-inclusive and cover all areas of activity. It is a restricted snapshot and it only presents a few viewpoints. The complexity and difficulties with high temperature superconductivity are well illustrated by the Buddhist parable of the blind men trying to describe ''experimentally'' an elephant. These very same facts clearly illustrate that this is an extremely active field, with many unanswered questions, and with a great future potential for discoveries and progress in many (sometimes unpredictable) directions. It is very important to stress that, independently of any current or future applications, this is a very important area of basic research.

  15. Content Validity and Psychometric Characteristics of the "Knowledge about Older Patients Quiz" for Nurses Using Item Response Theory.

    Science.gov (United States)

    Dikken, Jeroen; Hoogerduijn, Jita G; Kruitwagen, Cas; Schuurmans, Marieke J

    2016-11-01

    To assess the content validity and psychometric characteristics of the Knowledge about Older Patients Quiz (KOP-Q), which measures nurses' knowledge regarding older hospitalized adults and their certainty regarding this knowledge. Cross-sectional. Content validity: general hospitals. Psychometric characteristics: nursing school and general hospitals in the Netherlands. Content validity: 12 nurse specialists in geriatrics. Psychometric characteristics: 107 first-year and 78 final-year bachelor of nursing students, 148 registered nurses, and 20 nurse specialists in geriatrics. Content validity: The nurse specialists rated each item of the initial KOP-Q (52 items) on relevance. Ratings were used to calculate Item-Content Validity Index and average Scale-Content Validity Index (S-CVI/ave) scores. Items with insufficient content validity were removed. Psychometric characteristics: Ratings of students, nurses, and nurse specialists were used to test for different item functioning (DIF) and unidimensionality before item characteristics (discrimination and difficulty) were examined using Item Response Theory. Finally, norm references were calculated and nomological validity was assessed. Content validity: Forty-three items remained after assessing content validity (S-CVI/ave = 0.90). Psychometric characteristics: Of the 43 items, two demonstrating ceiling effects and 11 distorting ability estimates (DIF) were subsequently excluded. Item characteristics were assessed for the remaining 30 items, all of which demonstrated good discrimination and difficulty parameters. Knowledge was positively correlated with certainty about this knowledge. The final 30-item KOP-Q is a valid, psychometrically sound, comprehensive instrument that can be used to assess the knowledge of nursing students, hospital nurses, and nurse specialists in geriatrics regarding older hospitalized adults. It can identify knowledge and certainty deficits for research purposes or serve as a tool in educational

  16. GI-POP: a combinational annotation and genomic island prediction pipeline for ongoing microbial genome projects.

    Science.gov (United States)

    Lee, Chi-Ching; Chen, Yi-Ping Phoebe; Yao, Tzu-Jung; Ma, Cheng-Yu; Lo, Wei-Cheng; Lyu, Ping-Chiang; Tang, Chuan Yi

    2013-04-10

    Sequencing of microbial genomes is important because of microbial-carrying antibiotic and pathogenetic activities. However, even with the help of new assembling software, finishing a whole genome is a time-consuming task. In most bacteria, pathogenetic or antibiotic genes are carried in genomic islands. Therefore, a quick genomic island (GI) prediction method is useful for ongoing sequencing genomes. In this work, we built a Web server called GI-POP (http://gipop.life.nthu.edu.tw) which integrates a sequence assembling tool, a functional annotation pipeline, and a high-performance GI predicting module, in a support vector machine (SVM)-based method called genomic island genomic profile scanning (GI-GPS). The draft genomes of the ongoing genome projects in contigs or scaffolds can be submitted to our Web server, and it provides the functional annotation and highly probable GI-predicting results. GI-POP is a comprehensive annotation Web server designed for ongoing genome project analysis. Researchers can perform annotation and obtain pre-analytic information include possible GIs, coding/non-coding sequences and functional analysis from their draft genomes. This pre-analytic system can provide useful information for finishing a genome sequencing project. Copyright © 2012 Elsevier B.V. All rights reserved.

  17. GiA Roots: software for the high throughput analysis of plant root system architecture

    Science.gov (United States)

    2012-01-01

    Background Characterizing root system architecture (RSA) is essential to understanding the development and function of vascular plants. Identifying RSA-associated genes also represents an underexplored opportunity for crop improvement. Software tools are needed to accelerate the pace at which quantitative traits of RSA are estimated from images of root networks. Results We have developed GiA Roots (General Image Analysis of Roots), a semi-automated software tool designed specifically for the high-throughput analysis of root system images. GiA Roots includes user-assisted algorithms to distinguish root from background and a fully automated pipeline that extracts dozens of root system phenotypes. Quantitative information on each phenotype, along with intermediate steps for full reproducibility, is returned to the end-user for downstream analysis. GiA Roots has a GUI front end and a command-line interface for interweaving the software into large-scale workflows. GiA Roots can also be extended to estimate novel phenotypes specified by the end-user. Conclusions We demonstrate the use of GiA Roots on a set of 2393 images of rice roots representing 12 genotypes from the species Oryza sativa. We validate trait measurements against prior analyses of this image set that demonstrated that RSA traits are likely heritable and associated with genotypic differences. Moreover, we demonstrate that GiA Roots is extensible and an end-user can add functionality so that GiA Roots can estimate novel RSA traits. In summary, we show that the software can function as an efficient tool as part of a workflow to move from large numbers of root images to downstream analysis. PMID:22834569

  18. Credit Card Quiz.

    Science.gov (United States)

    Marks, Jeff

    2000-01-01

    Describes an activity in which students design credit cards and discover for themselves the mathematical realities of buying on credit. Employs multiple-intelligence theory to increase the chance that all students will be reached. (YDS)

  19. Rate Your Risk Quiz

    Science.gov (United States)

    ... Cares Peers Support Ask the Doctor My Food Coach Nutrition Dialysis Patient & Family Resources Emergency Resources A ... State Charity Registration Disclosures © 2017 National Kidney Foundation, Inc., 30 East 33rd Street, New York, NY 10016, ...

  20. Secondhand Smoke Quiz

    Science.gov (United States)

    ... Start Today Having a Baby? SmokefreeMOM is a text messaging program that provides quitting tips and encouragement. Sign ... and encouragement for pregnant women. › HealthyYou TXT A text message program ... of topics. › Craving Journal [.pdf file] If you know when you are ...

  1. Allergic Rhinitis Quiz

    Science.gov (United States)

    ... rhinitis, allergic asthma, conjunctivitis (eye allergy) or stinging insect allergy. Allergy shots often lead to lasting relief ... AAAAI Foundation Donate American Academy of Allergy Asthma & Immunology 555 East Wells Street Suite 1100, Milwaukee , WI ...

  2. Teen Diabetes Quiz Answers

    Science.gov (United States)

    ... home the night before is one way to eat healthy foods at school. Use leftovers from dinner or make a tuna sandwich and add raw ... something fun with you—take a walk after dinner instead of watching TV and playing ... B You can eat at fast-food restaurants, just not every day. ...

  3. Allergic Rhinitis Quiz

    Science.gov (United States)

    ... Conditions Drug Guide Conditions Dictionary Just for Kids Library School Tools Videos Virtual Allergist Education & Training Careers in ... Support the AAAAI Foundation Donate Utility navigation Español Journals Annual Meeting Member Login / My Membership Search navigation ...

  4. Pet Allergy Quiz

    Science.gov (United States)

    ... Conditions Drug Guide Conditions Dictionary Just for Kids Library School Tools Videos Virtual Allergist Education & Training Careers in ... Support the AAAAI Foundation Donate Utility navigation Español Journals Annual Meeting Member Login / My Membership Search navigation ...

  5. Quiz-R-us

    DEFF Research Database (Denmark)

    Marchetti, Emanuela; Valente, Andrea

    2018-01-01

    in Occupational Therapy offered in the city of Odense, located in the Southern region of Denmark. For the bachelor level we worked with the University College Lillebaelt (UCL), and for the master level we involved the University of Southern Denmark (SDU). We also involved students from the bachelor program in Web...

  6. Skin Allergy Quiz

    Science.gov (United States)

    ... long time. True False False: This is called contact dermatitis, which is often due to nickel. Question 9 ... dermatitis. True False True: This is called Irritant contact dermatitis which is more common than allergic contact dermatitis. ...

  7. Picture Quiz (questions).

    Science.gov (United States)

    Chatha, Hamid Aizaz; Nakash, Shaun

    2005-01-01

    A 75-year-old man was referred to hospital with a 24 hour history of severe neck pain, associated with fever, rigors and mild confusion. The pain radiated into his arms and was exacerbated by neck movements. Eight days prior to admission he had developed loose stools for 3 days. There was no history of trauma, and no other features of meningism. He gave a past history of ischemic heart disease and atrial fibrillation for which he was taking warfarin. Examination revealed a pyrexia of 38.3°C. There was tenderness over the cervical spine but no other positive findings. Neurological examination was unremarkable.

  8. GeoNetwork powered GI-cat: a geoportal hybrid solution

    Science.gov (United States)

    Baldini, Alessio; Boldrini, Enrico; Santoro, Mattia; Mazzetti, Paolo

    2010-05-01

    To the aim of setting up a Spatial Data Infrastructures (SDI) the creation of a system for the metadata management and discovery plays a fundamental role. An effective solution is the use of a geoportal (e.g. FAO/ESA geoportal), that has the important benefit of being accessible from a web browser. With this work we present a solution based integrating two of the available frameworks: GeoNetwork and GI-cat. GeoNetwork is an opensource software designed to improve accessibility of a wide variety of data together with the associated ancillary information (metadata), at different scale and from multidisciplinary sources; data are organized and documented in a standard and consistent way. GeoNetwork implements both the Portal and Catalog components of a Spatial Data Infrastructure (SDI) defined in the OGC Reference Architecture. It provides tools for managing and publishing metadata on spatial data and related services. GeoNetwork allows harvesting of various types of web data sources e.g. OGC Web Services (e.g. CSW, WCS, WMS). GI-cat is a distributed catalog based on a service-oriented framework of modular components and can be customized and tailored to support different deployment scenarios. It can federate a multiplicity of catalogs services, as well as inventory and access services in order to discover and access heterogeneous ESS resources. The federated resources are exposed by GI-cat through several standard catalog interfaces (e.g. OGC CSW AP ISO, OpenSearch, etc.) and by the GI-cat extended interface. Specific components implement mediation services for interfacing heterogeneous service providers, each of which exposes a specific standard specification; such components are called Accessors. These mediating components solve providers data modelmultiplicity by mapping them onto the GI-cat internal data model which implements the ISO 19115 Core profile. Accessors also implement the query protocol mapping; first they translate the query requests expressed

  9. [Genotyping of ABO Blood Group in Partial Population of Yunnan Province by SNaPshot Technology].

    Science.gov (United States)

    Yu, S X; Zeng, F M; Jin, Y Z; Wan, H J; Zhai, D; Xing, Y M; Cheng, B W

    2017-06-01

    To detect the genotype of ABO blood group by SNaPshot technology. DNA were extracted from the peripheral blood samples with known blood groups (obtained by serology) of 107 unrelated individuals in Yunnan. Six SNP loci of the 261th, 297th, 681th, 703th, 802th, and 803th nucleotide positions were detected by SNaPshot Multiplex kit, and relevant genetics parameters were calculated. In 107 blood samples, the allele frequencies of types A, B, O A , and O G were 0.355 1, 0.168 2, 0.230 0 and 0.247 6, respectively, while that of types A G and cis AB were not detected. The genotyping results of ABO blood group were consistent with that of serologic testing. SNaPshot technology can be adapted for genotyping of ABO blood group. Copyright© by the Editorial Department of Journal of Forensic Medicine

  10. A review of snapshot multidimensional optical imaging: Measuring photon tags in parallel

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Liang, E-mail: gaol@illinois.edu [Department of Electrical and Computer Engineering, University of Illinois at Urbana–Champaign, 306 N. Wright St., Urbana, IL 61801 (United States); Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana–Champaign, 405 North Mathews Avenue, Urbana, IL 61801 (United States); Wang, Lihong V., E-mail: lhwang@wustl.edu [Optical imaging laboratory, Department of Biomedical Engineering, Washington University in St. Louis, One Brookings Dr., MO, 63130 (United States)

    2016-02-29

    Multidimensional optical imaging has seen remarkable growth in the past decade. Rather than measuring only the two-dimensional spatial distribution of light, as in conventional photography, multidimensional optical imaging captures light in up to nine dimensions, providing unprecedented information about incident photons’ spatial coordinates, emittance angles, wavelength, time, and polarization. Multidimensional optical imaging can be accomplished either by scanning or parallel acquisition. Compared with scanning-based imagers, parallel acquisition–also dubbed snapshot imaging–has a prominent advantage in maximizing optical throughput, particularly when measuring a datacube of high dimensions. Here, we first categorize snapshot multidimensional imagers based on their acquisition and image reconstruction strategies, then highlight the snapshot advantage in the context of optical throughput, and finally we discuss their state-of-the-art implementations and applications.

  11. Iconic Destination: a Snapshot of Sustainable Tourism in Pisa

    Directory of Open Access Journals (Sweden)

    Silvia Sarti

    2015-12-01

    Full Text Available Tourism is one of the world's fastest growing industries. According to the World Tourism Organization, Italy is the fifth most visited country in the world, with more than 47.7 million tourists a year (2013. At the same time, the increasing number of studies focused on sustainable tourism demonstrates a growing interest about the topic. In addition, practitioners’ attitude is changing and the most important actors of the market are acting in a more sustainable way and developing reports on their eco-friendly performances. Nowadays, the entire supply chain maybe environmentally sustainable. From the reservation to the post-holiday phase, it is possible to select the more eco-friendly suppliers. The main companies operating in the different stages of the process are demonstrating a concrete interest on sustainable development. This new challenge is generated through the information flow between local authorities, private firms and final customers. We propose to make a reflection based on the latter actors’ attitude. Our research aims to investigate the level of sensitivity of tourists about environmental sustainability from two different perspectives: self-evaluation and real purchasing behavior. We conducted a face-to-face survey among tourists in Pisa, in Piazza dei Miracoli, during May 2015. By using a structured questionnaire, we gathered primary data from a sample of 406 respondents. We selected respondents randomly. Pisa is the perfect location to obtain information from several typologies of tourists, with different levels of awareness of sustainable issues. Itis one of the most important tourist destination in Italy and it is an iconic destination recognized worldwide thanks to the attractiveness of the leading tower. The results of our study is a snapshot of the current level of awareness among tourists. The analysis of the questionnaires revealed tourist profiles, their eco-friendly behaviors, their concerns about sustainability

  12. Pressure spectra from single-snapshot tomographic PIV

    Science.gov (United States)

    Schneiders, Jan F. G.; Avallone, Francesco; Pröbsting, Stefan; Ragni, Daniele; Scarano, Fulvio

    2018-03-01

    The power spectral density and coherence of temporal pressure fluctuations are obtained from low-repetition-rate tomographic PIV measurements. This is achieved by extension of recent single-snapshot pressure evaluation techniques based upon the Taylor's hypothesis (TH) of frozen turbulence and vortex-in-cell (VIC) simulation. Finite time marching of the measured instantaneous velocity fields is performed using TH and VIC. Pressure is calculated from the resulting velocity time series. Because of the theoretical limitations, the finite time marching can be performed until the measured flow structures are convected out of the measurement volume. This provides a lower limit of resolvable frequency range. An upper limit is given by the spatial resolution of the measurements. Finite time-marching approaches are applied to low-repetition-rate tomographic PIV data of the flow past a straight trailing edge at 10 m/s. Reference results of the power spectral density and coherence are obtained from surface pressure transducers. In addition, the results are compared to state-of-the-art experimental data obtained from time-resolved tomographic PIV performed at 10 kHz. The time-resolved approach suffers from low spatial resolution and limited maximum acquisition frequency because of hardware limitations. Additionally, these approaches strongly depend upon the time kernel length chosen for pressure evaluation. On the other hand, the finite time-marching approaches make use of low-repetition-rate tomographic PIV measurements that offer higher spatial resolution. Consequently, increased accuracy of the power spectral density and coherence of pressure fluctuations are obtained in the high-frequency range, in comparison to the time-resolved measurements. The approaches based on TH and VIC are found to perform similarly in the high-frequency range. At lower frequencies, TH is found to underestimate coherence and intensity of the pressure fluctuations in comparison to time-resolved PIV

  13. Arteriojejunal Fistula Presenting with Recurrent Obscure GI Hemorrhage in a Patient with a Failed Pancreas Allograft

    Directory of Open Access Journals (Sweden)

    Nirmit Desai

    2013-01-01

    Full Text Available We present a case of a patient with a failed pancreaticoduodenal allograft with exocrine enteric-drainage who developed catastrophic gastrointestinal (GI hemorrhage. Over the course of a week, she presented with recurrent GI bleeds of obscure etiology. Multiple esophago-gastro-duodenoscopic (EGD and colonoscopic evaluations failed to reveal the source of the hemorrhage. A capsule endoscopy and a technetium-labeled red blood cells (RBC imaging study were similarly unrevealing for source of bleeding. She subsequently developed hemorrhagic shock requiring emergent superior mesenteric arteriography. Run off images revealed an external iliac artery aneurysm with fistulization into the jejunum. Coiled embolization was attempted but abandoned because of hemodynamic instability. Deployment of a covered endovascular stent into the right external iliac artery over the fistula site resulted in immediate hemodynamic stabilization. A high index of suspicion for arterioenteric fistulae is needed for diagnosis of this uncommon but eminently treatable form of GI hemorrhage in this patient population.

  14. Endoscopic management and outcomes of pregnant women hospitalized for nonvariceal upper GI bleeding: a nationwide analysis.

    Science.gov (United States)

    Nguyen, Geoffrey C; Dinani, Amreen M; Pivovarov, Kevin

    2010-11-01

    Upper GI endoscopy has an important diagnostic and therapeutic role in the management of nonvariceal upper GI bleeding (NVUGB). To characterize nationwide patterns of utilization of upper GI endoscopy in pregnant women with NVUGB and to assess health outcomes. Retrospective cohort study. Participating hospitals from the Nationwide Inpatient Sample, 1998-2007. Pregnant and age-matched nonpregnant women admitted for NVUGB. The study population was classified as pregnant women with NVUGB (n = 1210) and nonpregnant women with NVUGB (n = 6050). Rate of upper GI endoscopy, maternal mortality, fetal death/complications, and premature delivery. Pregnant women were less likely than nonpregnant women to undergo upper GI endoscopy (26% vs 69%; P < .0001) even after adjustment for comorbidities, transfusion requirement, and the presence of hypovolemic shock (adjusted odds ratio, 0.19; 95% confidence interval, 0.16-0.22). Among those who underwent endoscopy, pregnant women were less likely to undergo the procedure within 24 hours of admission (50% vs 57%; P = .02). Mortality was lower among pregnant women compared with nonpregnant women (0% vs 0.6%; P = .006). In comparing outcomes between those who did and did not undergo endoscopy, there was no difference in fetal loss (0.2% vs 0.6%), fetal distress/complications (2.7% vs 2.6%), or premature delivery (7.3% vs 6.4%). The study was based on administrative data. A conservative nonendoscopic approach is common in the management of pregnant women with NVUGB and is not associated with worse maternal or fetal outcomes. Upper GI endoscopy is, however, safe when judiciously implemented in the actively bleeding patient. Copyright © 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.

  15. Development of an online library of patient-reported outcome measures in gastroenterology: The GI-PRO database

    OpenAIRE

    Khanna, P; Agarwal, N; Khanna, D; Hays, RD; Chang, L; Bolus, R; Melmed, G; Whitman, CB; Kaplan, RM; Ogawa, R; Snyder, B; Spiegel, BM

    2014-01-01

    OBJECTIVES:Because gastrointestinal (GI) illnesses can cause physical, emotional, and social distress, patient-reported outcomes (PROs) are used to guide clinical decision making, conduct research, and seek drug approval. It is important to develop a mechanism for identifying, categorizing, and evaluating the over 100 GI PROs that exist. Here we describe a new, National Institutes of Health (NIH)-supported, online PRO clearinghouse-the GI-PRO database.METHODS: Using a protocol developed by th...

  16. Animal data on GI-tract uptake of plutonium - implications for environmental dose assessments

    International Nuclear Information System (INIS)

    Kocher, D.C.; Ryan, M.T.

    1983-01-01

    A selection of published data on GI-tract uptake of ingested plutonium in animals is reviewed for the purpose of estimating an uptake fraction which would be appropriate for environmental dose assessments in adult humans. Recent data in the adult rat and guinea pig suggest that a GI-tract uptake fraction of 10 -3 would be a reasonable and prudent choice for ingestion of environmental plutonium by adults. This value is a factor of ten larger than the value currently recommended by the International Commission on Radiological Protection for assessing doses from occupational exposures. (author)

  17. Löögiüksuse "Admiral Pitka" formeerimine ja tegevus / Toomas Hiio

    Index Scriptorium Estoniae

    Hiio, Toomas, 1965-

    2008-01-01

    Johan Pitka tegevusest 1940-1944. Tema lähematest kaastöölistest Paul Laamannist ja Evald Karotoomest. Löögiüksuse formeerimisest Saksa ametkondade asjaajamises ning Evald Karotoomi ja Paul Laamanni tunnistuste järgi. Kes kuulusid Pitka löögirühma. Saadik Aleksander Warma suhtumisest Pitka löögiüksuse moodustamisse. Vastuolust Soomes viibinud mõõdukate eestlaste ja Harald Vellneri ning Karl Talpaku vahel. Löögirühma tegevusest Tallinnas sakslaste taandumise ajal.

  18. A SOA broker solution for standard discovery and access services: the GI-cat framework

    Science.gov (United States)

    Boldrini, Enrico

    2010-05-01

    GI-cat ideal users are data providers or service providers within the geoscience community. The former have their data already available through an access service (e.g. an OGC Web Service) and would have it published through a standard catalog service, in a seamless way. The latter would develop a catalog broker and let users query and access different geospatial resources through one or more standard interfaces and Application Profiles (AP) (e.g. OGC CSW ISO AP, CSW ebRIM/EO AP, etc.). GI-cat actually implements a broker components (i.e. a middleware service) which carries out distribution and mediation functionalities among "well-adopted" catalog interfaces and data access protocols. GI-cat also publishes different discovery interfaces: the OGC CSW ISO and ebRIM Application Profiles (the latter coming with support for the EO and CIM extension packages) and two different OpenSearch interfaces developed in order to explore Web 2.0 possibilities. An extended interface is also available to exploit all available GI-cat features, such as interruptible incremental queries and queries feedback. Interoperability tests performed in the context of different projects have also pointed out the importance to enforce compatibility with existing and wide-spread tools of the open source community (e.g. GeoNetwork and Deegree catalogs), which was then achieved. Based on a service-oriented framework of modular components, GI-cat can effectively be customized and tailored to support different deployment scenarios. In addition to the distribution functionality an harvesting approach has been lately experimented, allowing the user to switch between a distributed and a local search giving thus more possibilities to support different deployment scenarios. A configurator tool is available in order to enable an effective high level configuration of the broker service. A specific geobrowser was also naturally developed, for demonstrating the advanced GI-cat functionalities. This client

  19. 2014 Rural Clinical School Training and Support Program Snapshot survey.

    Science.gov (United States)

    Mendis, Kumara; Greenhill, Jennene; Walker, Judi; Bailey, Jannine; Croft, Amanda; Doyle, Zelda; McCrossin, Timothy; Stevens, Wendy

    2015-01-01

    The Rural Clinical Training and Support (RCTS) program is an Australian Government initiative to address the shortage of medical practitioners within rural and remote Australia. There is a large amount of published information about the RCTS program and rural medical student cohorts who have undertaken short- and long-term rotations. However, very little is known about the academic and professional staff involved in the program, a knowledge gap that may impact workforce and succession planning. To address this, the Federation of Rural Australian Medical Educators (FRAME) initiated the pilot 2014 RCTS Snapshot survey to obtain data on the current RCTS workforce. All professional, academic and clinical academic staff (fixed-term and continuing, regardless of fraction) employed through the RCTS program were invited to complete a short, web-based survey. The survey was conducted from March to June 2014. The quantitative variables in the survey included demographics (age and gender), rural background and exposure, employment history in rural/regional areas and at rural clinical schools (RCS), experience and expertise, reasons for working at RCS, and future employment intentions. The last three questions also were of a qualitative open-ended format to allow respondents to provide additional details regarding their reasons for working at RCSs and their future intentions. The estimated total RCTS workforce was 970. A total of 413 responses were received and 316 (40.9%) complete responses analysed. The majority of respondents were female (71%), the 40-60-year age group was predominant (28%), and professional staff constituted the majority (62%). The below 40-year age group had more professionals than academics (21% vs 12%) and more than 62% of academics were aged above 50 years. Notably, there were no academics aged less than 30 years. The percentage of professional staff with a rural background was higher (62%) than that of academics with a rural background (42%). However

  20. Zombid, kanep ja psühhedeelia / Tristan Priimägi

    Index Scriptorium Estoniae

    Priimägi, Tristan, 1976-

    2010-01-01

    Katusekino filmiprogrammi filmidest: Alejandro Jodorowsky filmist "Püha mägi" ("Holy Mountain", Mehhiko-USA 1973), George A. Romero filmist "Elavate surnute öö" ("Night of the Living Dead", USA 1968), Louis Gasnier' filmist "Kanepihullus" ("Reefer Madness", USA 1936)

  1. Uudiste lõpp ehk kuidas Facebook ajakirjanduse alla neelas / Priit Hõbemägi

    Index Scriptorium Estoniae

    Hõbemägi, Priit, 1957-

    2016-01-01

    Priit Hõbemägi refereeris Cambridge ülikooli professori ja Columbia ajakirjanduskooli digitaalse ajakirjanduse keskuse direktori Emily Belli meedia­maailmas laineid löönud kõnet sotsiaalmeedia ettevõtete mõju kasvust uudiste levitamise ja sellega raha teenimise üle

  2. A note on negative customers, GI/G/1 workload, and risk processes

    NARCIS (Netherlands)

    R.J. Boucherie; O.J. Boxma (Onno); K. Sigman

    1996-01-01

    textabstractRecently the workload distribution in the M/G/1 queue with work removal has been analysed, and has been shown to exhibit a generalized Pollaczek-Khintchine form. The latter result is explained in this note by transforming the model into a standard GI/G/1 queue. Some extensions are also

  3. Teismeliste üksindus ja kommerts - teema nii Londonis kui ka meil / Tõnis Mägi

    Index Scriptorium Estoniae

    Mägi, Tõnis, 1948-

    2007-01-01

    Muusik räägib, mida huvitavat ta nägi Londonis. Lähemalt Peter Shafferi näidendi "Equus" lavastusest, peaosades Richard Griffith ja Daniel Radcliffe. Artikkel ilmub Teatrikülgedel rubriigis "Teater & küljed" 5/17

  4. Sundmüügi põhiseaduslikud alused / Kadriann Ikkonen

    Index Scriptorium Estoniae

    Ikkonen, Kadriann, 1976-

    2004-01-01

    Sissenõudja ja võlgniku omandipõhiõiguse kollisioonist sundmüügi (ja üldse täitemenetluse) käigus ning võimalustest selle lahendamiseks, teistest sundmüüki õigustavatest põhiseaduse sätetest

  5. Tiit Linnamägi - metsaga peab olema sina peal / Merle Rips

    Index Scriptorium Estoniae

    Rips, Merle, 1950-

    2015-01-01

    Raplamaal Märjamaa vallas Purga külas Orava talus elab tänavu metsakultuuri kandja austava nimetuse pälvinud loodusemees Tiit Linnamägi. Kodumetsi majandab ta poeg Märdiga nii, et sealsed looduslikud ja kultuurilised rikkused säiliksid. Vestlusest Tiit ja Märt Linnamägiga

  6. Es war einmal ... : raamatunäitus baltisaksa kirjandusest / Sirje Lusmägi, Tiiu Reimo

    Index Scriptorium Estoniae

    Lusmägi, Sirje, 1952-

    2012-01-01

    2011. a augustis Tallinnas toimunud baltisaksa kultuuripäevade raames avati Tallinna Keskraamatukogus ka raamatunäitus, korraldajaks Baltisaksa Kultuuri Selts Eestis. Näituse koostasid Sirje Lusmägi ja Tiiu Reimo RR-i ja TLÜAR-i kogude põhjal

  7. Functional activity of Gi alpha protein in detergent resistant membrane domains from rat brain cortex

    Czech Academy of Sciences Publication Activity Database

    Stöhr, Jiří; Rudajev, Vladimír; Bouřová, Lenka; Lisý, Václav; Novotný, Jiří; Svoboda, Petr

    2007-01-01

    Roč. 101, Suppl.1 (2007), s. 52-52 ISSN 0022-3042. [European Society for Neurochemistry Meeting /17./. 19.05.2007-22.05.2007, Salamanca] Institutional research plan: CEZ:AV0Z50110509 Keywords : cpo1 * GABAB receptor * Gi protein * membrane domains Subject RIV: ED - Physiology

  8. Effects of Dietary Yogurt on the Healthy Human Gastrointestinal (GI) Microbiome

    Science.gov (United States)

    Lisko, Daniel J.; Johnston, G. Patricia; Johnston, Carl G.

    2017-01-01

    The gastrointestinal (GI) tract performs key functions that regulate the relationship between the host and the microbiota. Research has shown numerous benefits of probiotic intake in the modulation of immune responses and human metabolic processes. However, unfavorable attention has been paid to temporal changes of the microbial composition and diversity of the GI tract. This study aimed to investigate the effects of yogurt consumption on the GI microbiome bacteria community composition, structure and diversity during and after a short-term period (42 days). We used a multi-approach combining classical fingerprinting techniques (T-RFLPs), Sanger analyses and Illumina MiSeq 16S rRNA gene amplicon sequencing to elucidate bacterial communities and Lactobacilli and Bifidobacteria populations within healthy adults that consume high doses of yogurt daily. Results indicated that overall GI microbial community and diversity was method-dependent, yet we found individual specific changes in bacterial composition and structure in healthy subjects that consumed high doses of yogurt throughout the study. PMID:28212267

  9. Wet and coarse diets in broiler nutrition: development of the GI tract and performance

    NARCIS (Netherlands)

    Khoa, M.A.

    2007-01-01

    Diet structure and conformation during the starter phase play an important role in the functional development of the gastro-intestinal (GI) tract of broiler chicken, in particular the foregut segment.\\\\u00a0Feed structure has a significant effect on the development of the foregut segments in broiler

  10. Elektrooniline laulu- ja tantsupidu / Jamie Lidell ; interv. Tristan Priimägi

    Index Scriptorium Estoniae

    Lidell, Jamie

    2006-01-01

    Tristan Priimägi külastas 25. mail Inglismaal Brighton festivalil üritust "Warp Moves", kus intervjueeris Eesti Kunstimuuseumis 2. juuni öösel üritusel "KUMU Öö" esinevaid artiste Jamie Lidelli ja Plaidi

  11. Bookinghouse peatas Air Balticu piletite müügi / Ann-Marii Nergi

    Index Scriptorium Estoniae

    Nergi, Ann-Marii

    2011-01-01

    Lennupiletite vahendamisega tegelev Leedu portaal Bookinghouse peatas 27. juunil makseraskustes vaevleva Läti lennundusfirma Air Balticu piletite müügi, põhjendades seda Läti lennufirma finantsseisu kohta avalikuks tulnud infoga. Air Baltic väidab, et Bookinghouse on korduvalt reisijatele valeinformatsiooni jaganud ja teeb seda ka praegu

  12. Public administration GI-based web-sites for spatial planning

    DEFF Research Database (Denmark)

    Campagna, Michele; Arleth, Mette

    2005-01-01

    This paper presents the results of an ongoing comparative study on the accessibility of Geographic Information at public authorities’ websites in Denmark and Italy. Qualitative and quantitative mappings of the level of accessibility to GI in the two countries are made and the results are compared...

  13. Soovahetus, Priimägi ja Baudrillard / Kadi Herkül

    Index Scriptorium Estoniae

    Herkül, Kadi

    1999-01-01

    Dieter Lesage'i "Pärast orgiat" raadioteatris, režissöör Tamur Tohver, helirežissöör Küllike Valdma, osatäitjana Linnar Priimägi, esietendus Klassikaraadios 11. apr. ja Vikerraadios 18. apr.

  14. Heavy-traffic analysis for the GI/G/1 queue with heavy-tailed distributions

    NARCIS (Netherlands)

    O.J. Boxma (Onno); J.W. Cohen

    1997-01-01

    textabstractWe consider a $GI/G/1$ queue in which the service time distribution and/or the interarrival time distribution has a heavy tail, i.e., a tail behaviour like $t^{-nu$ with $1

  15. Identification, purification and characterization of laterosporulin, a novel bacteriocin produced by Brevibacillus sp. strain GI-9.

    Directory of Open Access Journals (Sweden)

    Pradip Kumar Singh

    Full Text Available BACKGROUND: Bacteriocins are antimicrobial peptides that are produced by bacteria as a defense mechanism in complex environments. Identification and characterization of novel bacteriocins in novel strains of bacteria is one of the important fields in bacteriology. METHODOLOGY/FINDINGS: The strain GI-9 was identified as Brevibacillus sp. by 16 S rRNA gene sequence analysis. The bacteriocin produced by strain GI-9, namely, laterosporulin was purified from supernatant of the culture grown under optimal conditions using hydrophobic interaction chromatography and reverse-phase HPLC. The bacteriocin was active against a wide range of Gram-positive and Gram-negative bacteria. MALDI-TOF experiments determined the precise molecular mass of the peptide to be of 5.6 kDa and N-terminal sequencing of the thermo-stable peptide revealed low similarity with existing antimicrobial peptides. The putative open reading frame (ORF encoding laterosporulin and its surrounding genomic region was fished out from the draft genome sequence of GI-9. Sequence analysis of the putative bacteriocin gene did not show significant similarity to any reported bacteriocin producing genes in database. CONCLUSIONS: We have identified a bacteriocin producing strain GI-9, belonging to the genus Brevibacillus sp. Biochemical and genomic characterization of laterosporulin suggests it as a novel bacteriocin with broad spectrum antibacterial activity.

  16. Identification, purification and characterization of laterosporulin, a novel bacteriocin produced by Brevibacillus sp. strain GI-9.

    Science.gov (United States)

    Singh, Pradip Kumar; Chittpurna; Ashish; Sharma, Vikas; Patil, Prabhu B; Korpole, Suresh

    2012-01-01

    Bacteriocins are antimicrobial peptides that are produced by bacteria as a defense mechanism in complex environments. Identification and characterization of novel bacteriocins in novel strains of bacteria is one of the important fields in bacteriology. The strain GI-9 was identified as Brevibacillus sp. by 16 S rRNA gene sequence analysis. The bacteriocin produced by strain GI-9, namely, laterosporulin was purified from supernatant of the culture grown under optimal conditions using hydrophobic interaction chromatography and reverse-phase HPLC. The bacteriocin was active against a wide range of Gram-positive and Gram-negative bacteria. MALDI-TOF experiments determined the precise molecular mass of the peptide to be of 5.6 kDa and N-terminal sequencing of the thermo-stable peptide revealed low similarity with existing antimicrobial peptides. The putative open reading frame (ORF) encoding laterosporulin and its surrounding genomic region was fished out from the draft genome sequence of GI-9. Sequence analysis of the putative bacteriocin gene did not show significant similarity to any reported bacteriocin producing genes in database. We have identified a bacteriocin producing strain GI-9, belonging to the genus Brevibacillus sp. Biochemical and genomic characterization of laterosporulin suggests it as a novel bacteriocin with broad spectrum antibacterial activity.

  17. Kas praktikant on ettevõttes teretulnud? / Valev Mägi, Hedi Hepner, Aku Sorainen ... [jt.

    Index Scriptorium Estoniae

    2009-01-01

    Küsimusele vastavad: Mainori Kõrgkooli üliõpilasesinduse esimees Valev Mägi, Tartu Ülikooli õigusteaduskonna üliõpilane Hedi Hepner, Advokaadibüroo Sorainen juhtiv partner Aku Sorainen, Swedbanki personali planeerimise ja arendamise osakonna juhataja Signe Vaks-Saareoja, Lääne maasekretär Epp Mitt

  18. Living in the face of death: Studies on palliative care in upper GI cancer patients

    NARCIS (Netherlands)

    M.J. Uitdehaag (Madeleen)

    2012-01-01

    textabstractThis thesis explores palliative care provided to patients with advanced upper gastrointestinal (GI) cancer. The 5-year survival rates for these cancer sites range between 4 and 17%, which implies that many of these patients require palliative care. Considering the fact that there is no

  19. redMaGiC: selecting luminous red galaxies from the DES Science Verification data

    Energy Technology Data Exchange (ETDEWEB)

    Rozo, E. [Univ. of Arizona, Tucson, AZ (United States). et al.

    2016-05-30

    We introduce redMaGiC, an automated algorithm for selecting Luminous Red Galaxies (LRGs). The algorithm was developed to minimize photometric redshift uncertainties in photometric large-scale structure studies. redMaGiC achieves this by self-training the color-cuts necessary to produce a luminosity-thresholded LRG sam- ple of constant comoving density. Additionally, we demonstrate that redMaGiC photo-zs are very nearly as accurate as the best machine-learning based methods, yet they require minimal spectroscopic training, do not suffer from extrapolation biases, and are very nearly Gaussian. We apply our algorithm to Dark Energy Survey (DES) Science Verification (SV) data to produce a redMaGiC catalog sampling the redshift range z ϵ [0.2,0.8]. Our fiducial sample has a comoving space density of 10-3 (h-1Mpc)-3, and a median photo-z bias (zspec zphoto) and scatter (σz=(1 + z)) of 0.005 and 0.017 respectively.The corresponding 5σ outlier fraction is 1.4%. We also test our algorithm with Sloan Digital Sky Survey (SDSS) Data Release 8 (DR8) and Stripe 82 data, and discuss how spectroscopic training can be used to control photo-z biases at the 0.1% level.

  20. Revealing the Relationship between Reading Interest and Critical Thinking Skills through Remap GI and Remap Jigsaw

    Science.gov (United States)

    Zubaidah, Siti; Corebima, Aloysius Duran; Mahanal, Susriyati; Mistianah

    2018-01-01

    The aim of this research was to reveal the relationship between student's reading interest and critical thinking skills through Reading Concept Map Group Investigation (Remap GI) and Reading Concept Map Jigsaw (Remap Jigsaw) learning models. To do so, two science classes from first grade of two Senior High Schools in Malang, Indonesia were…

  1. Eesti Miss teeb videofilmi / Evelyn Mikomägi ; interv. Valdo Jahilo

    Index Scriptorium Estoniae

    Mikomägi, Evelyn

    2001-01-01

    Eesti Miss Estonia 2000 Evelyn Mikomägi tegi koos sõbra, Sven-Olof Svenne Englundiga dokfilmi Küprosel peetud maailma suurimast iludusvõistlusest Miss Universe 2000. Neile kuulub ühisfirma "Living Frames" Rootsis, mille peategevus on suunatud 16mm ja 35mm filmide tootmisele

  2. Effects of Dietary Yogurt on the Healthy Human Gastrointestinal (GI Microbiome

    Directory of Open Access Journals (Sweden)

    Daniel J. Lisko

    2017-02-01

    Full Text Available The gastrointestinal (GI tract performs key functions that regulate the relationship between the host and the microbiota. Research has shown numerous benefits of probiotic intake in the modulation of immune responses and human metabolic processes. However, unfavorable attention has been paid to temporal changes of the microbial composition and diversity of the GI tract. This study aimed to investigate the effects of yogurt consumption on the GI microbiome bacteria community composition, structure and diversity during and after a short-term period (42 days. We used a multi-approach combining classical fingerprinting techniques (T-RFLPs, Sanger analyses and Illumina MiSeq 16S rRNA gene amplicon sequencing to elucidate bacterial communities and Lactobacilli and Bifidobacteria populations within healthy adults that consume high doses of yogurt daily. Results indicated that overall GI microbial community and diversity was method-dependent, yet we found individual specific changes in bacterial composition and structure in healthy subjects that consumed high doses of yogurt throughout the study.

  3. Hypoglycemia: Role of Hypothalamic Glucose-Inhibited (GI) Neurons in Detection and Correction.

    Science.gov (United States)

    Zhou, Chunxue; Teegala, Suraj B; Khan, Bilal A; Gonzalez, Christina; Routh, Vanessa H

    2018-01-01

    Hypoglycemia is a profound threat to the brain since glucose is its primary fuel. As a result, glucose sensors are widely located in the central nervous system and periphery. In this perspective we will focus on the role of hypothalamic glucose-inhibited (GI) neurons in sensing and correcting hypoglycemia. In particular, we will discuss GI neurons in the ventromedial hypothalamus (VMH) which express neuronal nitric oxide synthase (nNOS) and in the perifornical hypothalamus (PFH) which express orexin. The ability of VMH nNOS-GI neurons to depolarize in low glucose closely parallels the hormonal response to hypoglycemia which stimulates gluconeogenesis. We have found that nitric oxide (NO) production in low glucose is dependent on oxidative status. In this perspective we will discuss the potential relevance of our work showing that enhancing the glutathione antioxidant system prevents hypoglycemia associated autonomic failure (HAAF) in non-diabetic rats whereas VMH overexpression of the thioredoxin antioxidant system restores hypoglycemia counterregulation in rats with type 1 diabetes.We will also address the potential role of the orexin-GI neurons in the arousal response needed for hypoglycemia awareness which leads to behavioral correction (e.g., food intake, glucose administration). The potential relationship between the hypothalamic sensors and the neurocircuitry in the hindbrain and portal mesenteric vein which is critical for hypoglycemia correction will then be discussed.

  4. Hypoglycemia: Role of Hypothalamic Glucose-Inhibited (GI Neurons in Detection and Correction

    Directory of Open Access Journals (Sweden)

    Chunxue Zhou

    2018-03-01

    Full Text Available Hypoglycemia is a profound threat to the brain since glucose is its primary fuel. As a result, glucose sensors are widely located in the central nervous system and periphery. In this perspective we will focus on the role of hypothalamic glucose-inhibited (GI neurons in sensing and correcting hypoglycemia. In particular, we will discuss GI neurons in the ventromedial hypothalamus (VMH which express neuronal nitric oxide synthase (nNOS and in the perifornical hypothalamus (PFH which express orexin. The ability of VMH nNOS-GI neurons to depolarize in low glucose closely parallels the hormonal response to hypoglycemia which stimulates gluconeogenesis. We have found that nitric oxide (NO production in low glucose is dependent on oxidative status. In this perspective we will discuss the potential relevance of our work showing that enhancing the glutathione antioxidant system prevents hypoglycemia associated autonomic failure (HAAF in non-diabetic rats whereas VMH overexpression of the thioredoxin antioxidant system restores hypoglycemia counterregulation in rats with type 1 diabetes.We will also address the potential role of the orexin-GI neurons in the arousal response needed for hypoglycemia awareness which leads to behavioral correction (e.g., food intake, glucose administration. The potential relationship between the hypothalamic sensors and the neurocircuitry in the hindbrain and portal mesenteric vein which is critical for hypoglycemia correction will then be discussed.

  5. Snapshots of the “breaking” of the H–H bond in the oxidative ...

    Indian Academy of Sciences (India)

    Snapshots of the “breaking” of the H–H bond in the oxidative addition of H2 to a metal centre. SAIKAT DUTTA and BALAJI R JAGIRDAR*. Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560 012 e-mail: jagirdar@ipc.iisc.ernet.in. Abstract. Three new monocationic molecular hydrogen ...

  6. Energy Transition Initiative: Island Energy Snapshot - Antigua and Barbuda; NREL (National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-05-20

    This profile provides a snapshot of the energy landscape of Antigua and Barbuda, an independent nation in the Leeward Islands in the eastern Caribbean Sea. Antigua and Barbuda’s utility rates are approximately $0.37 U.S. dollars (USD) per kilowatt-hour (kWh), which is above the Caribbean regional average of $0.33 USD/kWh.

  7. Energy Transition Initiative: Island Energy Snapshot - Guadeloupe; NREL (National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-05-27

    This profile provides a snapshot of the energy landscape of Guadeloupe, an overseas region of France located in the eastern Caribbean Sea. Guadeloupe’s utility rates are approximately $0.18 U.S. dollars (USD) per kilowatt-hour (kWh), below the Caribbean regional average of $0.33 USD/kWh.

  8. Ten Cities, 1997-1998: A Snapshot of Family Homelessness across America.

    Science.gov (United States)

    Homes for the Homeless, Inc., New York, NY.

    In 1997, the Institute for Children and Poverty of Homes for the Homeless joined with more than 58 organizations from 10 cities across the country to develop a national snapshot of family homelessness in the United States. Nearly 800 families were surveyed. This report presents the results of this research. The typical homeless family in the…

  9. Reduction of snapshots for MIMO radar detection by block/group orthogonal matching pursuit

    KAUST Repository

    Ali, Hussain El Hosiny; Ahmed, Sajid; Al-Naffouri, Tareq Y.; Alouini, Mohamed-Slim

    2014-01-01

    localization problem with compressive sensing. Specifically, we try to solve the problem of estimation of target location in MIMO radar by group and block sparsity algorithms. It will lead us to a reduced number of snapshots required and also we can achieve

  10. Typing of 49 autosomal SNPs by SNaPshot in the Slovenian population

    DEFF Research Database (Denmark)

    Drobnic, Katja; Børsting, Claus; Rockenbauer, Eszter

    2010-01-01

    A total of 157 unrelated individuals residing in Slovenia were typed for 49 of the autosomal single nucleotide polymorphisms (SNPs) in the SNPforID 52plex with the SNaPshot assay. We obtained full SNP profiles in all but one individual and perfect concordance was obtained in duplicated analyses...

  11. Energy Transition Initiative: Island Energy Snapshot - Trinidad and Tobago; NREL (National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-05-20

    This profile provides a snapshot of the energy landscape of Trinidad and Tobago, a two-island nation located off the coast of Venezuela. Trinidad and Tobago’s electricity rates are some of the lowest in the Caribbean at approximately $0.04 per kilowatt-hour (kWh), well below the regional average of $0.33/kWh.

  12. Energy Transition Initiative: Island Energy Snapshot - U.S. Virgin Islands (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    2015-03-01

    This profile provides a snapshot of the energy landscape of the U.S. Virgin Islands (USVI) - St. Thomas, St. John, and St. Croix. The Virgin Islands archipelago makes up the northern portion of the Lesser Antilles and the western island group of the Leeward Islands, forming the border between the Atlantic Ocean and the Caribbean Sea.

  13. From Seurat to Snapshots: What the Visual Arts Could Contribute to Education.

    Science.gov (United States)

    Duncum, Paul

    1996-01-01

    Advocates reconceptualizing visual arts as a core subject embodying key elements of experiential learning and critical thinking through an interdisciplinary approach. Illustrates this approach with a discussion of the interconnected issues surrounding family snapshots (social history, aesthetics, technological advancement). Discusses issues of…

  14. PENERAPAN MODEL PEMBELAJARAN GROUP INVESTIGATION (GI UNTUK MENINGKATKAN AKTIVITAS DAN HASIL BELAJAR SISTEM PENGAPIAN KONVENSIONAL

    Directory of Open Access Journals (Sweden)

    Ahfid Husni Mubarok

    2016-06-01

    Full Text Available The aim of this research to determine the increase in activity and learning outcomes conventional ignition system by applying the learning model of Group Investigation (GI. The hypothesis in this research is application of Group Investigation (GI learning model’s can increase the activity and learning outcomes conventional ignition system. The research is a Classroom Action Research (CAR conducted collaboratively between teachers and researches. The subjects in this study is 20 students from class TKR of SMK, while the object of this research is the application of Group Investigation learning model’s (GI to increase the activity and student learning outcomes in conventional ignition system subjects. The experiment was conducted with three (3 cycles. Data collection techniques using observation, testing and documentation. Data were analyzed using quantitative description of the statistical formula. Results of this research by applying the Group Investigation learning model’s (GI showed the presence of increasing activity and learning outcomes conventional ignition system in every cycle. This is indicated by: 1. The increase of learning outcomes was showed by percentage of learning activity more than (≥ enough, before action only 25% increased by 22,4% into 47,4% after doing first cycles. When doing second cycles increased by 10,5% into 63,2% and third cycles increased by 10,5% into 73,7%. 2. Another increase was showed by learning outcomes of students who passed, from learning outcomes before action only 40% and after doing first cycles increased by 12,6% to 52,6%. Then second cycles increased by 8,5% into 61,1% and third cycles increased by 17,8% into 78,9%. From the above data it can be conclude by applying the learning model of Group Investigation (GI on the subjects of conventional ignition system  can increase the activity and learning outcomes, in line with the hypotesis of this action research

  15. Diagnostic accuracy of age and alarm symptoms for upper GI malignancy in patients with dyspepsia in a GI clinic: a 7-year cross-sectional study.

    Directory of Open Access Journals (Sweden)

    Hooman Khademi

    Full Text Available OBJECTIVES: We investigated whether using demographic characteristics and alarm symptoms can accurately predict cancer in patients with dyspepsia in Iran, where upper GI cancers and H. pylori infection are common. METHODS: All consecutive patients referred to a tertiary gastroenterology clinic in Tehran, Iran, from 2002 to 2009 were invited to participate in this study. Each patient completed a standard questionnaire and underwent upper gastrointestinal endoscopy. Alarm symptoms included in the questionnaire were weight loss, dysphagia, GI bleeding, and persistent vomiting. We used logistic regression models to estimate the diagnostic value of each variable in combination with other ones, and to develop a risk-prediction model. RESULTS: A total of 2,847 patients with dyspepsia participated in this study, of whom 87 (3.1% had upper GI malignancy. Patients reporting at least one of the alarm symptoms constituted 66.7% of cancer patients compared to 38.9% in patients without cancer (p<0.001. Esophageal or gastric cancers in patients with dyspepsia was associated with older age, being male, and symptoms of weight loss and vomiting. Each single predictor had low sensitivity and specificity. Using a combination of age, alarm symptoms, and smoking, we built a risk-prediction model that distinguished between high-risk and low-risk individuals with an area under the ROC curve of 0.85 and acceptable calibration. CONCLUSIONS: None of the predictors demonstrated high diagnostic accuracy. While our risk-prediction model had reasonable accuracy, some cancer cases would have remained undiagnosed. Therefore, where available, low cost endoscopy may be preferable for dyspeptic older patient or those with history of weight loss.

  16. Meie maamees Brüsselis esimene / Aivar Niinemägi ; interv. Sirje Pärismaa

    Index Scriptorium Estoniae

    Niinemägi, Aivar

    2002-01-01

    Aivar Niinemägi esindab põllumajandus-kaubanduskoda, talupidajate ning põllumajandustootjate keskliitu ja ühistegelist liitu üleeuroopalise talunike ja põllumajandusliitude ühenduse COPA ja ühistute esinduse COGECA juures. A. Niinemägi eluloolisi andmeid

  17. GI-SVM: A sensitive method for predicting genomic islands based on unannotated sequence of a single genome.

    Science.gov (United States)

    Lu, Bingxin; Leong, Hon Wai

    2016-02-01

    Genomic islands (GIs) are clusters of functionally related genes acquired by lateral genetic transfer (LGT), and they are present in many bacterial genomes. GIs are extremely important for bacterial research, because they not only promote genome evolution but also contain genes that enhance adaption and enable antibiotic resistance. Many methods have been proposed to predict GI. But most of them rely on either annotations or comparisons with other closely related genomes. Hence these methods cannot be easily applied to new genomes. As the number of newly sequenced bacterial genomes rapidly increases, there is a need for methods to detect GI based solely on sequences of a single genome. In this paper, we propose a novel method, GI-SVM, to predict GIs given only the unannotated genome sequence. GI-SVM is based on one-class support vector machine (SVM), utilizing composition bias in terms of k-mer content. From our evaluations on three real genomes, GI-SVM can achieve higher recall compared with current methods, without much loss of precision. Besides, GI-SVM allows flexible parameter tuning to get optimal results for each genome. In short, GI-SVM provides a more sensitive method for researchers interested in a first-pass detection of GI in newly sequenced genomes.

  18. Epidemiology of RHDV2 (Lagovirus europaeus/GI.2) in free-living wild European rabbits in Portugal.

    Science.gov (United States)

    Rouco, C; Abrantes, J; Serronha, A; Lopes, A M; Maio, E; Magalhães, M J; Blanco, E; Bárcena, J; Esteves, P J; Santos, N; Alves, P C; Monterroso, P

    2018-04-01

    As the detection of the first outbreak of a novel aetiological agent of rabbit haemorrhagic disease commonly called RHDV2 or RHDVb (Lagovirus europaeus/GI.2, henceforth GI.2) in France in 2010, the virus rapidly spread throughout continental Europe and nearby islands such as Great Britain, Sardinia, Sicily, the Azores and the Canary Islands among others. The outbreaks of this new lagovirus cause important economic losses in rabbitries, and ecological disruptions by affecting the conservation of rabbit-sensitive top predators. We analysed 550 rabbit carcasses collected in the field between May 2013 and March 2016, to investigate the epidemiology of GI.2 in free-living populations and to perform a comparative analysis with the epidemiology of classical rabbit haemorrhagic disease virus forms (RHDV, henceforth GI.1) in Portugal. Rabbits were sexed, aged and liver and blood samples were collected for subsequent RHDV screening and serology. A total of 172 samples were PCR-positive to GI.2, whereas GI.1 strains were not detected in any of the samples. The outbreaks of GI.2 revealed a marked seasonality, with peaks during the breeding season (November-May). We also found that approximately, one-third of free-ranging European rabbits in Portugal have seroconverted to GI.2. We demonstrate that the GI.2 lagovirus is currently widespread in wild populations in Portugal and is affecting a high proportion of adults and juveniles. Therefore, ongoing monitoring and surveillance are required to assess the effects of GI.2 on wild rabbit populations, its evolution, and to guide management actions aimed at mitigating the impacts of rabbit declines in the ecosystem and in rural economies. © 2017 Blackwell Verlag GmbH.

  19. War and Marriage: Assortative Mating and the World War II GI Bill.

    Science.gov (United States)

    Larsen, Matthew F; McCarthy, T J; Moulton, Jeremy G; Page, Marianne E; Patel, Ankur J

    2015-10-01

    World War II and its subsequent GI Bill have been widely credited with playing a transformative role in American society, but there have been few quantitative analyses of these historical events' broad social effects. We exploit between-cohort variation in the probability of military service to investigate how WWII and the GI Bill altered the structure of marriage, and find that it had important spillover effects beyond its direct effect on men's educational attainment. Our results suggest that the additional education received by returning veterans caused them to "sort" into wives with significantly higher levels of education. This suggests an important mechanism by which socioeconomic status may be passed on to the next generation.

  20. Gastric cirsoid aneurysm: Uncommon cause of death from upper GI bleed

    Directory of Open Access Journals (Sweden)

    Tatiana Bihun, BA

    2017-11-01

    Full Text Available Gastric cirsoid aneurysm is an arterial malformation found in the submucosa of the stomach. It is a rare, but potentially life-threatening cause of gastrointestinal bleed. We present a case of a 48 year old male who presented to the ER unconscious, unresponsive, pale, and tachycardic. Patient expired and an autopsy was performed. Upon examination blood was found in the GI tract. During examination an arterial malformation was found in the body of the stomach. Histological samples were taken and the findings were consistent with gastric cirsoid aneurysm. Diagnosis can be made through endoscopy, angiography, or red cell scanning. Current treatment is hemostasis achieved by either thermal, regional injection or mechanical therapies. Multiple therapies are found to be more successful than monotherapy. Gastric cirsoid aneurysms are thought to make up <5% of upper GI bleeds, however clinicians should be mindful when working up a differential diagnosis.

  1. Comparison of CT findings with upper GI series and surgical findings

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Jin Kyo; Suh, Soo Jhi; Kim, Soon Yong [School of Medicine, Kyung Hee University, Seoul (Korea, Republic of)

    1981-09-15

    The authors made comparative studies of CT findings with upper GI series and surgical findings in 20 cases of histologically proven gastric cancers. The identification of chickening of gastric wall and local and remote metastasis by CT was thought to be great value in treatment planning and prediction of prognosis of the patients. The results were as follows: 1. Of 20 cases, 19 cases demonstrated thickening of gastric wall. Among 3 cases suggested as early cancer on upper GI series, 2 cases demonstrated thickened gastric wall on CT and it was proved to be advanced cancer at surgery. 2. Out of 8 cases showed no definite metastasis on CT, 4 cases had malignant infiltration histologically in the regional lymph nodes. But they were less than 1.5 cm in diameter. 3. The frequency order of remote metastasis found by CT was pancreas, liver, left adrenal gland and lung in organs and retroperitoneal, retrocrural and regional nodes in lymph nodes.

  2. Portal Hypertensive Colopathy with Pelvic Varices presenting as Severe Lower GI Bleed treated with TIPSS

    LENUS (Irish Health Repository)

    Murphy, SF

    2018-02-01

    We present the case of a 71-year-old lady with a background of significant alcohol intake who presented with frank lower gastrointestinal (GI) bleeding, lower abdominal pain and haemoglobin 6.3g\\/dL. CT abdominal angiogram showed right-sided colonic thickening, atrophic liver and enlarged superior mesenteric vein (SMV) and right-sided pelvic varix. This lead to a diagnosis of portal hypertensive colopathy secondary to alcoholic liver cirrhosis. The patient failed conservative management and underwent a Transjugular Intrahepatic Portosystemic Shunt (TIPSS) procedure. This lead to an immediate resolution of her lower-GI bleeding. Repeat CT at three weeks showed a decompressed SMV and resolution of the right-sided pelvic varix. The patient was discharged after three months following optimization of medical condition and social circumstances.

  3. Results of endoscopic vacuum-assisted closure device for treatment of upper GI leaks.

    Science.gov (United States)

    Bludau, Marc; Fuchs, Hans F; Herbold, Till; Maus, Martin K H; Alakus, Hakan; Popp, Felix; Leers, Jessica M; Bruns, Christiane J; Hölscher, Arnulf H; Schröder, Wolfgang; Chon, Seung-Hun

    2018-04-01

    Esophageal perforations and postoperative leakage of esophagogastrostomies are considered to be life-threatening conditions due to the potential development of mediastinitis and consecutive sepsis. Vacuum-assisted closure (VAC) techniques, a well-established treatment method for superficial infected wounds, are based on a negative pressure applied to the wound via a vacuum-sealed sponge. Endoluminal VAC (E-VAC) therapy as a treatment for GI leakages in the rectum was introduced in 2008. E-VAC therapy is a novel method, and experience regarding esophageal applications is limited. In this retrospective study, the experience of a high-volume center for upper GI surgery with E-VAC therapy in patients with leaks of the upper GI tract is summarized. To our knowledge, this series presents the largest patient cohort worldwide in a single-center study. Between October 2010 and January 2017, 77 patients with defects in the upper gastrointestinal tract were treated using the E-VAC application. Six patients had a spontaneous perforation, 12 patients an iatrogenic injury, and 59 patients a postoperative leakage in the upper gastrointestinal tract. Complete restoration of the esophageal defect was achieved in 60 of 77 patients. The average duration of application was 11.0 days, and a median of 2.75 E-VAC systems were used. For 21 of the 77 patients, E-VAC therapy was combined with the placement of self-expanding metal stents. This study demonstrates that E-VAC therapy provides an additional treatment option for esophageal wall defects. Esophageal defects and mediastinal abscesses can be treated with E-VAC therapy where endoscopic stenting may not be possible. A prospective multi-center study has to be directed to bring evidence to the superiority of E-VAC therapy for patients suffering from upper GI defects.

  4. Lühifilm "Argentiina tango" ja Ants Anderi elujanu / Margus Mikomägi

    Index Scriptorium Estoniae

    Mikomägi, Margus, 1956-

    2009-01-01

    Valmivast lühifilmist "Argentiina tango" (Film Tower Kuubis), mille stsenarist, kunstnik ja režissöör on Ervin Õunapuu. Viimasest võttepäevast Tallinnas Vabaduse väljaku kunstigaleriis, kus Margus Mikomägi oli ajakirjaniku rollis. Peaosas Roman Baskin. Kunstiteadlase osa mänginud Ants Anderist. Valik Ervin Õunapuu filme

  5. The busy period of order n in the GI/D/infinity queue

    International Nuclear Information System (INIS)

    Dvurecenskij, A.

    1982-01-01

    The problem of determination of the distribution function, integral equation and all moments of the busy period of order n, that is, the period when at least n servers are busy from infinitely many servers of the GI/D/infinity queueing system are investigated. The idle period of order n, i. e., the period between two neighbouring busy periods of order n is also studied. Those problems arise in the blob length determination in track chambers in high energy physics

  6. Orchestrating change: The thyroid hormones and GI-tract development in flatfish metamorphosis.

    Science.gov (United States)

    Gomes, A S; Alves, R N; Rønnestad, I; Power, D M

    2015-09-01

    Metamorphosis in flatfish (Pleuronectiformes) is a late post-embryonic developmental event that prepares the organism for the larval-to-juvenile transition. Thyroid hormones (THs) play a central role in flatfish metamorphosis and the basic elements that constitute the thyroid axis in vertebrates are all present at this stage. The advantage of using flatfish to study the larval-to-juvenile transition is the profound change in external morphology that accompanies metamorphosis making it easy to track progression to climax. This important lifecycle transition is underpinned by molecular, cellular, structural and functional modifications of organs and tissues that prepare larvae for a successful transition to the adult habitat and lifestyle. Understanding the role of THs in the maturation of organs and tissues with diverse functions during metamorphosis is a major challenge. The change in diet that accompanies the transition from a pelagic larvae to a benthic juvenile in flatfish is associated with structural and functional modifications in the gastrointestinal tract (GI-tract). The present review will focus on the maturation of the GI-tract during metamorphosis giving particular attention to organogenesis of the stomach a TH triggered event. Gene transcripts and biological processes that are associated with GI-tract maturation during Atlantic halibut metamorphosis are identified. Gene ontology analysis reveals core biological functions and putative TH-responsive genes that underpin TH-driven metamorphosis of the GI-tract in Atlantic halibut. Deciphering the specific role remains a challenge. Recent advances in characterizing the molecular, structural and functional modifications that accompany the appearance of a functional stomach in Atlantic halibut are considered and future research challenges identified. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. Pengaruh Distributed Generation Terhadap Stabilitas Transien Pada Sistem Distribusi (Studi Kasus: Penyulang Tl 2 Gi Tele )

    OpenAIRE

    Muhammad, Mahatir

    2017-01-01

    120402050 Penyulang TL 2 GI Tele pada jaringan distribusi listrik 20 kV terhubung dengan PLTMH Aek silang dan PLTMH Aek Sibundong dengan kapasitas masing-masing 750 kW. Distributed Generation (DG) dengan kapasitas yang kecil, akan mempengaruhi kestabilan sistem distribusi listrik. Begitu juga Distributed Generation (DG) yang mempunyai jumlah kapasitas yang besar mungkin dapat memberikan pengaruh lebih terhadap kestabilan sistem distribusi listrik. Untuk itu studi dan simu...

  8. Dose distributions of patients from chest fluoroscopy, upper GI-tract radiography and cinematography in Japan

    International Nuclear Information System (INIS)

    Kusama, T.; Kai, M.; Ohta, K.

    1996-01-01

    The per caput dose from medical exposure in Japan is several times higher than in other developed countries. There are no dose limitations for medical exposure. Then, the appropriate applications of radiation diagnosis/treatments (justification of practices) and the quality control of diagnosis/treatments (optimization of protection) are needed to reduce the doses from medical exposure. It is well documented that patient doses from a X-ray diagnosis are distributed in the broad range. Recently, the IAEA introduced guidance levels for some typical X-ray diagnosis and in vivo nuclear medicines. We carried out the investigation of dose distribution of patients from the X-ray examinations of chest, cardiovascular cinematography and upper GI-tract X-ray examination in order to give the basic information on the quality control of each X-ray diagnosis. These X-ray diagnoses are performed frequently in Japan, and especially chest X-ray examinations are carried out periodically to all population more than 18 years old as legal health check and GI-tract X-ray examinations to the persons more than 35 years old. The cardiovascular cinematography and the upper GI-tract X-ray examination bring higher effective dose for patients. More information is therefore, needed for the reduction and quality control of medical exposure in Japan. (author)

  9. Energy Transition Initiative: Island Energy Snapshot - Belize; U.S. Department of Energy (DOE), NREL (National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-03-01

    This profile provides a snapshot of the energy landscape of Belize, a Central American country bordering Mexico to the north, Guatemala to the west and south, and the Caribbean Sea to the east. Although not an island nation, Belize is included in this energy snapshot series because it is a member of the Caribbean Community (CARICOM), an alliance of 15 Caribbean nations in the region.

  10. Science from a glimpse: Hubble SNAPshot observations of massive galaxy clusters

    Science.gov (United States)

    Repp, A.; Ebeling, H.

    2018-06-01

    Hubble Space Telescope SNAPshot surveys of 86 X-ray selected galaxy clusters at 0.3 0.3. Examining the evolution of the slope of the cluster red sequence, we observe at best a slight decrease with redshift, indicating minimal age contribution since z ˜ 1. Congruent to previous studies' findings, we note that the two BCGs which are significantly bluer (≥5σ) than their clusters' red sequences reside in relaxed clusters and exhibit pronounced internal structure. Thanks to our targets' high X-ray luminosity, the subset of our sample observed with Chandra adds valuable leverage to the X-ray luminosity-optical richness relation, which, albeit with substantial scatter, is now clearly established from groups to extremely massive clusters of galaxies. We conclude that SNAPshot observations of MACS clusters stand to continue to play a vital pathfinder role for astrophysical investigations across the entire electromagnetic spectrum.

  11. INFLUENCE OF THE VIEWING GEOMETRY WITHIN HYPERSPECTRAL IMAGES RETRIEVED FROM UAV SNAPSHOT CAMERAS

    OpenAIRE

    Aasen, Helge

    2016-01-01

    Hyperspectral data has great potential for vegetation parameter retrieval. However, due to angular effects resulting from different sun-surface-sensor geometries, objects might appear differently depending on the position of an object within the field of view of a sensor. Recently, lightweight snapshot cameras have been introduced, which capture hyperspectral information in two spatial and one spectral dimension and can be mounted on unmanned aerial vehicles. This study investigates th...

  12. A snapshot of New England's immigrants: stocks, flows, and origins, 1990–2006

    OpenAIRE

    Antoniya Owens

    2009-01-01

    In recent years New England has experienced both net domestic outmigration and slow native population growth. Counteracting these trends, however, is the continued influx of immigrants from abroad. As a result, foreign-born residents play an increasingly important role in replenishing the region’s population and labor force. This article provides a snapshot of the size, recent growth, national origins, and period of arrival of the region’s foreign-born population.

  13. Factors related to late GI and GU complications in conformal and conventional radiation treatment of cancer of the prostate

    International Nuclear Information System (INIS)

    Schultheiss, Timothy E.; Lee, W. Robert; Hunt, Margie A.; Hanlon, Alexandra L.; Peter, Ruth S.; Hanks, Gerald E.

    1995-01-01

    Purpose: To assess the factors that predict for late GI and GU morbidity in radiation treatment of the prostate. Materials and Methods: Six hundred sixteen consecutive prostate cancer patients treated between 1985 and 1994 with conformal or conventional techniques were included in the analysis. All patients had at least 3 months followup (median 26 months) and received at least 65 Gy. Late GI morbidity was rectal bleeding (requiring more than 2 procedures) or proctitis. Late GU morbidity was cystitis or stricture. Univariate analysis compared the differences in the incidence of RTOG-EORTC grade 3 and 4 late morbidity by age (<60 versus ≥ 60 years), peracute side effects ≥ grade 1 (during treatment), subacute side effects ≥ grade 1 (0 to 90 days after treatment), irradiated volume parameters, and dose. Multivariate proportional hazards analysis includes these same variables in a model of time to complication. Multivariate logistic regression was used to analyze incidence of peracute and subacute GI and GU side effects by GI and GU comorbidities, performance status, pretreatment procedures (biopsy, TURP, etc.), age, treatment volume parameters, and peracute responses. Results: Peracute GI and GU side effects were noted in 441 and 442 patients, respectively. Subacute GI and GU side effects were noted in 34 and 54 patients, respectively. Subacute GI side effects were highly correlated with subacute GU side effects (p<0.00001). Late morbidities were not correlated with peracute side effects but were correlated with subacute side effects (both GI and GU). Thirteen of the 616 patients expressed grade 3 or 4 GI injuries 3 to 32 months after the end of treatment, with a mean of 13 months. The 6 GU morbidities occurred significantly later (9 - 52 months) with a mean of 33 months. Central axis dose and age less than 60 years were the only independent variables significantly related to the incidence of late GI morbidity on multivariate analysis. Subacute and peracute

  14. Tranexamic Acid for Lower GI Hemorrhage: A Randomized Placebo-Controlled Clinical Trial.

    Science.gov (United States)

    Smith, Stephen R; Murray, David; Pockney, Peter G; Bendinelli, Cino; Draganic, Brian D; Carroll, Rosemary

    2018-01-01

    Lower GI hemorrhage is a common source of morbidity and mortality. Tranexamic acid is an antifibrinolytic that has been shown to reduce blood loss in a variety of clinical conditions. Information regarding the use of tranexamic acid in treating lower GI hemorrhage is lacking. The aim of this trial was to determine the clinical efficacy of tranexamic acid when used for lower GI hemorrhage. This was a prospective, double-blind, placebo-controlled, randomized clinical trial. The study was conducted at a tertiary referral university hospital in Australia. Consecutive patients aged >18 years with lower GI hemorrhage requiring hospital admission from November 2011 to January 2014 were screened for trial eligibility (N = 265). A total of 100 patients were recruited after exclusions and were randomly assigned 1:1 to either tranexamic acid or placebo. The primary outcome was blood loss as determined by reduction in hemoglobin levels. The secondary outcomes were transfusion rates, transfusion volume, intervention rates for bleeding, length of hospital stay, readmission, and complication rates. There was no difference between groups with respect to hemoglobin drop (11 g/L of tranexamic acid vs 13 g/L of placebo; p = 0.9445). There was no difference with respect to transfusion rates (14/49 tranexamic acid vs 16/47 placebo; p = 0.661), mean transfusion volume (1.27 vs 1.93 units; p = 0.355), intervention rates (7/49 vs 13/47; p = 0.134), length of hospital stay (4.67 vs 4.74 d; p = 0.934), readmission, or complication rates. No complications occurred as a direct result of tranexamic acid use. A larger multicenter trial may be required to determine whether there are more subtle advantages with tranexamic acid use in some of the secondary outcomes. Tranexamic acid does not appear to decrease blood loss or improve clinical outcomes in patients presenting with lower GI hemorrhage in the context of this trial. see Video Abstract at http://links.lww.com/DCR/A453.

  15. An endoscopic study of upper-GI mucosal changes in patients with congestive heart failure.

    Science.gov (United States)

    Raja, Kaiser; Kochhar, Rakesh; Sethy, Pradeepta K; Dutta, Usha; Bali, Harinder K; Varma, Jagmohan S

    2004-12-01

    Congestive heart failure results in an increase in systemic venous pressure that is transmitted to the inferior vena cava and to the hepatic veins. This can cause GI vascular and mucosal congestion. The aim of this study was to define upper-GI mucosal changes in patients with congestive heart failure. A total of 57 patients with congestive heart failure presenting with GI symptoms underwent upper endoscopy. Echocardiography was performed in all patients to determine the ejection fraction and the degree of tricuspid regurgitation. Transabdominal US was performed to measure the diameters of the hepatic veins, the inferior vena cava, and the portal vein. The presence and the severity of gastropathy and duodenopathy were compared with the parameters relating to severity of cardiac failure. Of the 57 patients studied, gastric mucosal changes were observed in 50 (88%), duodenal mucosal changes in 31 (54%), and esophageal mucosal changes in none. Gastric mucosal changes were the following: mosaic-like pattern (n = 50), punctate spots (n = 34), thickened folds (n = 5), watermelon stomach (n = 3), and telangiectasia (n = 10). Duodenal mucosal changes were the following: mosaic-like pattern (n = 29), thickened folds (n = 8), and telangiectasia (n = 2). Upper-GI symptoms were associated with gastropathy ( p = 0.027) and duodenopathy ( p = 0.003). The presence and the severity of duodenopathy showed a high degree of positive correlation with the presence and the severity of gastropathy (gamma value 0.690; p value <0.001). Patients with gastropathy and duodenopathy had higher mean inferior vena cava and hepatic vein diameters than those without gastropathy and duodenopathy. The severity of duodenopathy but not that of gastropathy was significantly associated with increasing severity of tricuspid regurgitation ( p = 0.001), larger portal vein diameter ( p = 0.02), and lower ejection fraction ( p = 0.008). Among patients with congestive cardiac failure with GI symptoms, changes

  16. Making sense of snapshot data: ergodic principle for clonal cell populations.

    Science.gov (United States)

    Thomas, Philipp

    2017-11-01

    Population growth is often ignored when quantifying gene expression levels across clonal cell populations. We develop a framework for obtaining the molecule number distributions in an exponentially growing cell population taking into account its age structure. In the presence of generation time variability, the average acquired across a population snapshot does not obey the average of a dividing cell over time, apparently contradicting ergodicity between single cells and the population. Instead, we show that the variation observed across snapshots with known cell age is captured by cell histories, a single-cell measure obtained from tracking an arbitrary cell of the population back to the ancestor from which it originated. The correspondence between cells of known age in a population with their histories represents an ergodic principle that provides a new interpretation of population snapshot data. We illustrate the principle using analytical solutions of stochastic gene expression models in cell populations with arbitrary generation time distributions. We further elucidate that the principle breaks down for biochemical reactions that are under selection, such as the expression of genes conveying antibiotic resistance, which gives rise to an experimental criterion with which to probe selection on gene expression fluctuations. © 2017 The Author(s).

  17. A Mixed Land Cover Spatio-temporal Data Model Based on Object-oriented and Snapshot

    Directory of Open Access Journals (Sweden)

    LI Yinchao

    2016-07-01

    Full Text Available Spatio-temporal data model (STDM is one of the hot topics in the domains of spatio-temporal database and data analysis. There is a common view that a universal STDM is always of high complexity due to the various situation of spatio-temporal data. In this article, a mixed STDM is proposed based on object-oriented and snapshot models for modelling and analyzing landcover change (LCC. This model uses the object-oriented STDM to describe the spatio-temporal processes of land cover patches and organize their spatial and attributive properties. In the meantime, it uses the snapshot STDM to present the spatio-temporal distribution of LCC on the whole via snapshot images. The two types of models are spatially and temporally combined into a mixed version. In addition to presenting the spatio-temporal events themselves, this model could express the transformation events between different classes of spatio-temporal objects. It can be used to create database for historical data of LCC, do spatio-temporal statistics, simulation and data mining with the data. In this article, the LCC data in Heilongjiang province is used for case study to validate spatio-temporal data management and analysis abilities of mixed STDM, including creating database, spatio-temporal query, global evolution analysis and patches spatio-temporal process expression.

  18. Effects of genetically modified T2A-1 rice on the GI health of rats after 90-day supplement.

    Science.gov (United States)

    Yuan, Yanfang; Xu, Wentao; He, Xiaoyun; Liu, Haiyan; Cao, Sishuo; Qi, Xiaozhe; Huang, Kunlun; Luo, Yunbo

    2013-01-01

    Bacillus thuringiensis insecticidal toxin (Bt) rice will be commercialized as a main food source. Traditional safety assessments on genetically modified products pay little attention on gastrointestinal (GI) health. More data about GI health of Bt rice must be provided to dispel public' doubts about the potential effects on human health. We constructed an improved safety assessment animal model using a basic subchronic toxicity experiment, measuring a range of parameters including microflora composition, intestinal permeability, epithelial structure, fecal enzymes, bacterial activity, and intestinal immunity. Significant differences were found between rice-fed groups and AIN93G-fed control groups in several parameters, whereas no differences were observed between genetically modified and non-genetically modified groups. No adverse effects were found on GI health resulting from genetically modified T2A-1 rice. In conclusion, this study may offer a systematic safety assessment model for GM material with respect to the effects on GI health.

  19. Uudised : Neeme Järvi San Franciscos. Tõnis Mägi Moskvas. TMKK Norras ja Ungaris / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2000-01-01

    N. Järvi juhatab San Francisco Ooperis Rimski-Korsakovi ooperit "Tsaari mõrsja", esietendus 11. sept. T. Mägi esines 1. sept. Eesti Suursaatkonnas Moskvas. TMKK Kammerkoori kontsertreisidest Norrasse ja Ungarisse

  20. Effects of genetically modified T2A-1 rice on the GI health of rats after 90-day supplement

    OpenAIRE

    Yuan, Yanfang; Xu, Wentao; He, Xiaoyun; Liu, Haiyan; Cao, Sishuo; Qi, Xiaozhe; Huang, Kunlun; Luo, Yunbo

    2013-01-01

    Bacillus thuringiensis insecticidal toxin (Bt) rice will be commercialized as a main food source. Traditional safety assessments on genetically modified products pay little attention on gastrointestinal (GI) health. More data about GI health of Bt rice must be provided to dispel public' doubts about the potential effects on human health. We constructed an improved safety assessment animal model using a basic subchronic toxicity experiment, measuring a range of parameters including microflora ...

  1. Videofluoroscopy versus upper G.I. endoscopy: A comparative study as a diagnostic tool in patients presenting with dysphagia

    OpenAIRE

    Sharwak Ramlan; Sai Manohar; Gangadhara Somayaji

    2015-01-01

    Background and Objective: Dysphagia is a major symptom in many of the patients coming to the hospital. There can be various causes of dysphagia and its accurate diagnosis shows the way for the necessary treatment. Videofluoroscopy and upper gastrointestinal (GI) endoscopy are the two most commonly employed primary investigating modalities in assessing dysphagia. The objective of the study was to compare videofluoroscopy and upper GI endoscopy and establish a primary diagnostic tool for assess...

  2. Expression of bovine herpesvirus 1 glycoproteins gI and gIII in transfected murine cells

    International Nuclear Information System (INIS)

    Fitzpatrick, D.R.; Zamb, T.; Parker, M.D.; van Drunen Littel-van den Hurk, S.; Babiuk, L.A.; Lawman, M.J.P.

    1988-01-01

    Genes encoding two of the major glycoproteins of bovine herpesvirus 1 (BHV-1), gI and gIII, were cloned into the eucaryotic expression vectors pRSVcat and pSV2neo and transfected into murine LMTK - cells, and cloned cell lines were established. The relative amounts of gI or gIII expressed from the two vectors were similar. Expression of gI was cell associated and localized predominantly in the perinuclear region, but nuclear and plasma membrane staining was also observed. Expression of gI was additionally associated with cell fusion and the formation of polykaryons and giant cells. Expression of gIII was localized predominantly in the nuclear and plasma membranes. Radioimmunoprecipitation in the presence or absence of tunicamycin revealed that the recombinant glycoproteins were proteolytically processed and glycosylated and had molecular weights similar to those of the forms of gI and gIII expressed in BHV-1 infected bovine cells. However, both recombinant glycoproteins were glycosylated to a lesser extent than were the forms found in BHV-1 infected bovine cells. For gI, a deficiency in N-linked glycosylated of the amino-terminal half of the protein was identified; for gIII, a deficiency in O-linked glycosylation was implicated. The reactivity pattern of a panel of gI- and gIII-specific monoclonal antibodies, including six which recognize conformation-dependent epitopes, was found to be unaffected by the glycosylation differences and was identical for transfected of BHV-1-infected murine cells. Use of the transfected cells as targets in immune-mediated cytotoxicity assays demonstrated the functional recognition of recombinant gI and gIII by murine antibody and cytotoxic T lymphocytes

  3. Postmortem computed tomographic (PMCT) demonstration of the relation between gastrointestinal (GI) distension and hepatic portal venous gas (HPVG)

    International Nuclear Information System (INIS)

    Shiotani, Seiji; Kohno, Mototsugu; Ohashi, Noriyoshi; Yamazaki, Kentaro; Nakayama, Hidetsugu; Watanabe, Ko

    2004-01-01

    The purpose of this study was to investigate the relation between gastrointestinal (GI) distension and hepatic portal venous gas (HPVG) on postmortem computed tomography (PMCT). Our subjects were 190 PMCT obtained within two hours of non-traumatic death [175 patients underwent cardiopulmonary resuscitation (CPR) and 15 patients did not undergo CPR]. We evaluated the incidence and location of GI distension (0=no distension, 1=stomach and duodenum, 2=more distal than 1) and HPVG (0=no gas, 1=left lobe, 2=1+right anterior lobe, 3=2+right posterior lobe). GI distension (grade 0/1/2=58/55/62 patients) and HPVG (grade 0/1/2/3=114/10/28/23 patients) were observed in 175 patients who underwent CPR. The grade of HPVG increased significantly in accordance with the advancement of GI distension. Fifteen patients without undergoing CPR showed no GI distension but one patient showed grade 1 HPVG. PMCT indicates the presence of a relation between GI distension and HPVG. (author)

  4. An MX/GI/1/N queue with close-down and vacation times

    Directory of Open Access Journals (Sweden)

    Andreas Frey

    1999-01-01

    Full Text Available An MX/GI/1/N finite capacity queue with close-down time, vacation time and exhaustive service discipline is considered under the partial batch acceptance strategy as well as under the whole batch acceptance strategy. Applying the supplementary variable technique the queue length distribution at an arbitrary instant and at a departure epoch is obtained under both strategies, where no assumption on the batch size distribution is made. The loss probabilities and the Laplace-Stieltjes transforms of the waiting time distribution of the first customer and of an arbitrary customer of a batch are also given. Numerical examples give some insight into the behavior of the system.

  5. Identification of potent, nonabsorbable agonists of the calcium-sensing receptor for GI-specific administration.

    Science.gov (United States)

    Sparks, Steven M; Spearing, Paul K; Diaz, Caroline J; Cowan, David J; Jayawickreme, Channa; Chen, Grace; Rimele, Thomas J; Generaux, Claudia; Harston, Lindsey T; Roller, Shane G

    2017-10-15

    Modulation of gastrointestinal nutrient sensing pathways provides a promising a new approach for the treatment of metabolic diseases including diabetes and obesity. The calcium-sensing receptor has been identified as a key receptor involved in mineral and amino acid nutrient sensing and thus is an attractive target for modulation in the intestine. Herein we describe the optimization of gastrointestinally restricted calcium-sensing receptor agonists starting from a 3-aminopyrrolidine-containing template leading to the identification of GI-restricted agonist 19 (GSK3004774). Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. SCANIA müügi- ja teeninduskeskus. Tallinn, Peterburi tee 72 / Aivar Habakukk

    Index Scriptorium Estoniae

    Habakukk, Aivar

    1998-01-01

    Baltikumi suurima veokite ja busside müügi- ja hooldekeskuse projekteerimisel olid aluseks SCANIA teenindusjaamade tüüpsed ehituslikud lahendused ja firma teenindusjaamades eritöödele esitatavad nõuded. Hoone koosneb kolmest funktsionaalsest plokist : ühekorruseline kõrge remondi ja hooldeplokk ; varuosade ladu ning klienditeeninduse ja müügikeskus koosa bürooruumidega. Projekteerija : AS Arhitektibüroo Ehala & Irik. Arhitekt Priit Ehala. Sisekujundus : OÜ Stuudio Habakukk & Kivi. Peatöövõtkja : AS FCM. Projekt 1997, valmis 1998.

  7. Determination of Stress Profiles in Expanded Austenite by Combining Successive Layer Removal and GI-XRD

    DEFF Research Database (Denmark)

    Fernandes, Frederico Augusto Pires; Christiansen, Thomas Lundin; Somers, Marcel A. J.

    2014-01-01

    The present work deals with the evaluation of the residual-stress profile in expanded-austenite by successive removal steps using GI-XRD. Preliminary results indicate stresses of several GPa's from 111 and 200 diffraction lines. These stresses appear largest for the 200 reflection. The strain......-free lattice parameter decayed smoothly with depth, while for the compressive stress a maximum value is observed at some depth below the surface. Additionally a good agreement was found between the nitrogen profile determined with GDOES analysis and the strain-free lattice parameter from XRD....

  8. Effect of antibiotic decontamination of the GI tract on survival time after neutron and gamma irradiation

    International Nuclear Information System (INIS)

    Geraci, J.P.; Jackson, K.L.; Mariano, M.S.

    1984-01-01

    Antibiotic decontaminated and conventional rats were whole-body irradiated with 8 MeV neutrons (1.5 to 13 Gy) or 137 Cs gamma radiation (9 to 20 Gy). The animals were checked for survival at four hour intervals from the second to the seventh day postirradiation and at eight hour intervals on other days. Decontamination of the GI tract increased median survival time 1 to 5 days in this range of dose dependency, whereas the effect of decontamination was negligible for doses that produced mostly intestinal death. These results suggest that sepsis and endotoxin produced by bacteria from the intestinal tract play little role in acute intestinal radiation death

  9. Structural basis of G protein-coupled receptor-Gi protein interaction: formation of the cannabinoid CB2 receptor-Gi protein complex.

    Science.gov (United States)

    Mnpotra, Jagjeet S; Qiao, Zhuanhong; Cai, Jian; Lynch, Diane L; Grossfield, Alan; Leioatts, Nicholas; Hurst, Dow P; Pitman, Michael C; Song, Zhao-Hui; Reggio, Patricia H

    2014-07-18

    In this study, we applied a comprehensive G protein-coupled receptor-Gαi protein chemical cross-linking strategy to map the cannabinoid receptor subtype 2 (CB2)-Gαi interface and then used molecular dynamics simulations to explore the dynamics of complex formation. Three cross-link sites were identified using LC-MS/MS and electrospray ionization-MS/MS as follows: 1) a sulfhydryl cross-link between C3.53(134) in TMH3 and the Gαi C-terminal i-3 residue Cys-351; 2) a lysine cross-link between K6.35(245) in TMH6 and the Gαi C-terminal i-5 residue, Lys-349; and 3) a lysine cross-link between K5.64(215) in TMH5 and the Gαi α4β6 loop residue, Lys-317. To investigate the dynamics and nature of the conformational changes involved in CB2·Gi complex formation, we carried out microsecond-time scale molecular dynamics simulations of the CB2 R*·Gαi1β1γ2 complex embedded in a 1-palmitoyl-2-oleoyl-phosphatidylcholine bilayer, using cross-linking information as validation. Our results show that although molecular dynamics simulations started with the G protein orientation in the β2-AR*·Gαsβ1γ2 complex crystal structure, the Gαi1β1γ2 protein reoriented itself within 300 ns. Two major changes occurred as follows. 1) The Gαi1 α5 helix tilt changed due to the outward movement of TMH5 in CB2 R*. 2) A 25° clockwise rotation of Gαi1β1γ2 underneath CB2 R* occurred, with rotation ceasing when Pro-139 (IC-2 loop) anchors in a hydrophobic pocket on Gαi1 (Val-34, Leu-194, Phe-196, Phe-336, Thr-340, Ile-343, and Ile-344). In this complex, all three experimentally identified cross-links can occur. These findings should be relevant for other class A G protein-coupled receptors that couple to Gi proteins. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

  10. Taking a "Snapshot": Evaluation of a Conversation Aid for Identifying Psychosocial Needs in Young Adults with Cancer.

    Science.gov (United States)

    Poort, Hanneke; Souza, Phoebe M; Malinowski, Paige K; MacDougall, Katelyn M; Barysauskas, Constance M; Lau Greenberg, Teresa; Tulsky, James A; Fasciano, Karen M

    2018-05-21

    Young adults (YAs) aged 18-35 years with cancer often experience unmet psychosocial needs. We aimed to evaluate a conversation aid ("Snapshot") that offered a framework for discussing YA-specific psychosocial concerns between patients and clinicians. We developed and implemented Snapshot between 2014 and 2016 as part of a quality improvement initiative at Dana-Farber Cancer Institute. We extracted pre- and postimplementation data from chart documentation of psychosocial concerns. YAs and social workers provided qualitative feedback on the use of Snapshot in clinical care. Postintervention chart reviews revealed a significant increase in the median number of topics documented in charts after implementation of Snapshot (preintervention median = 9 [range: 1-15] vs. postintervention median = 11 [range 6-15]; p = 0.003). Overall, YAs and social workers reported that using Snapshot improved communication and consistency of psychosocial care, with documented improvement in the following domains: understanding illness (p psychosocial needs assessment among YAs with cancer. Implementation was successful in reducing variability identified in the preintervention cohort and increasing the number of YA-specific psychosocial topics discussed. A standardized conversation aid has the potential to improve quality of care for YAs by enabling early identification and intervention of psychosocial issues for all patients.

  11. Contrast media for fluoroscopic examinations of the GI and GU tracts: current challenges and recommendations.

    Science.gov (United States)

    Federle, Michael P; Jaffe, Tracy A; Davis, Peter L; Al-Hawary, Mahmoud M; Levine, Marc S

    2017-01-01

    One of the significant challenges facing radiologists who perform and interpret studies of the gastrointestinal and genitourinary systems have been periodic interruptions in the availability of barium and iodinated contrast media specially formulated for gastrointestinal (GI) and genitourinary (GU) studies. These interruptions are due to the US Food and Drug Administration's recent requirement for more stringent documentation of the safety and efficacy of contrast media and the consolidation among contrast manufacturers. Therefore, radiologists may be required to recommend an alternative means of evaluation, such as computed tomography, magnetic resonance, or endoscopy, or they may need to substitute a different formulation of a contrast agent not specifically developed for GI or GU use, for example the utilization of an agent designed and marketed for vascular use. This article reviews the current status of fluoroscopic contrast media, and provides suggestions and recommendations for the optimal and alternative use of contrast media formulations.

  12. Air-space pattern in lung metastasis from adenocarcinoma of the GI tract

    Energy Technology Data Exchange (ETDEWEB)

    Gaeta, M.; Volta, S.; Scribano, E. [Univ. of Messina (Italy)] [and others

    1996-03-01

    We retrospectively reviewed a series of proven lung metastasis to evaluate the frequency and CT features of metastases showing an air-space (lepidic) pattern of growth. CT examinations of 65 patients with proven lung metastasis from GI carcinomas were reviewed by three observers. Four CT features were used to classify lesions as air-space metastases: (a) air-space nodules; (b) parenchymal consolidation containing air bronchogram and/or showing angiogram sign; (c) focal or extensive ground-glass opacities; and (d) nodule(s) with a {open_quotes}halo{close_quotes} sign. Six of 65 patients showed air-space metastases: three from pancreatic carcinoma. two from colonic carcinoma, and one from jejunal carcinoma. In one case, metastasis appeared as extensive parenchymal consolidation associated with ground-glass opacities; in one as an area of ground-glass opacity; in one as an extensive parenchymal consolidation with air bronchogram; in one as parenchymal consolidations with angiogram sign and multiple nodules, some of these with halo sign; in one as air-space nodules and patchy air-space consolidations; and in one as a solitary nodule with halo sign. Our study shows that air-space lung metastasis from GI carcinomas is uncommon but not rare. On CT as well as microscopically, differential diagnosis between air-space metastasis and bronchioloalveolar carcinoma may be impossible. 13 refs., 5 figs., 1 tab.

  13. Computational Procedures for a Class of GI/D/k Systems in Discrete Time

    Directory of Open Access Journals (Sweden)

    Md. Mostafizur Rahman

    2009-01-01

    Full Text Available A class of discrete time GI/D/k systems is considered for which the interarrival times have finite support and customers are served in first-in first-out (FIFO order. The system is formulated as a single server queue with new general independent interarrival times and constant service duration by assuming cyclic assignment of customers to the identical servers. Then the queue length is set up as a quasi-birth-death (QBD type Markov chain. It is shown that this transformed GI/D/1 system has special structures which make the computation of the matrix R simple and efficient, thereby reducing the number of multiplications in each iteration significantly. As a result we were able to keep the computation time very low. Moreover, use of the resulting structural properties makes the computation of the distribution of queue length of the transformed system efficient. The computation of the distribution of waiting time is also shown to be simple by exploiting the special structures.

  14. Studies of GI bleeding with scintigraphy and the influence of vasopressin

    International Nuclear Information System (INIS)

    Alavi, A.; McLean, G.K.

    1981-01-01

    The management of patients with gastrointestinal (GI) bleeding depends on accurate localization of the site of hemorrhage. Endoscopy and arteriography, although successful in achieving this goal in the majority of patients, are invasive and have other shortcomings. The introduction of the 99mTc-sulfur colloid technique has greatly simplified the evaluation and management of these patients. This test is useful in detecting and localizing the bleeding site in the lower GI tract. Scintigraphy is now used as the initial study of choice in patients with rectal bleeding. Advances made in angiography and nuclear medicine techniques also have resulted in improved management of patients. Conservative approaches succeed in controlling hemorrhage in most patients. Vasopressin is the most widely tested agent and has been adopted by many as the preferred preparation for this purpose. Before the introduction of the 99mTc-sulfur colloid technique, angiography was used to monitor the effectiveness of this drug, whether administered intravenously or intraarterially. With the use of scintigraphy and intravenous administration of vasopressin, these patients now can be managed noninvasively. Only when the intravenous Pitressin infusion fails to stop hemorrhage, is the intraarterial approach considered. Surgery is used as a last resort when these measures fail to stop the bleeding

  15. Airway Management During Upper GI Endoscopic Procedures: State of the Art Review.

    Science.gov (United States)

    Goudra, Basavana; Singh, Preet Mohinder

    2017-01-01

    With the growing popularity of propofol mediated deep sedation for upper gastrointestinal (GI) endoscopic procedures, challenges are being felt and appreciated. Research suggests that management of the airway is anything but routine in this setting. Although many studies and meta-analyses have demonstrated the safety of propofol sedation administered by registered nurses under the supervision of gastroenterologists (likely related to the lighter degrees of sedation than those provided by anesthesia providers and is under medicolegal controversy in the United States), there is no agreement on the optimum airway management for procedures such as endoscopic retrograde cholangiopancreatography. Failure to rescue an airway at an appropriate time has led to disastrous consequences. Inability to evaluate and appreciate the risk factors for aspiration can ruin the day for both the patient and the health care providers. This review apprises the reader of various aspects of airway management relevant to the practice of sedation during upper GI endoscopy. New devices and modification of existing devices are discussed in detail. Recognizing the fact that appropriate monitoring is important for timely recognition and management of potential airway disasters, these issues are explored thoroughly.

  16. Application of GI-TPS Model to Skills Critical Thinking and Self Efficacy

    Directory of Open Access Journals (Sweden)

    Rusmansyah

    2017-12-01

    Full Text Available This research aims to know the: (1 the difference in critical thinking ability of students (2 difference in the results of learning (cognitive, affective, psychomotor (3 self efficacy of students (4 student response towards the learning model GI-TPS (Guided Inquiry-Think Pair Share on the hydrolysis of salt. This research use the pretest-posttest design nonequivalent control group design. A sample of 50 research students, namely class XI IPA 2 and XI IPA 3. Samples taken with purposive sampling technique. Engineering data collection using the test the critical thinking ability, cognitive learning results, observations, and the now. Analytical techniques descriptive analyses using data and analysis inferensial (test, test the normality of its homogeneity, and t-test. The results of this study suggest that (1 there is a difference significant critical thinking abilities (2 there is a difference in learning outcomes (cognitive, affective, psychomotor a significant (3 students who have self efficacy. (4 the students gave positive response towards the learning model GI-TPS material on the hydrolysis of salt.

  17. [Characterization of alumina adobe and sintered body of GI-infiltrated ceramic].

    Science.gov (United States)

    Wang, H; Chao, Y; Liao, Y; Liang, X; Zhu, Z; Gao, W

    2001-06-01

    This study was conducted to elucidate the mechanism of formation of porous structure by investigating the porosity of the alumina adobe and sintered body of GI-II Infiltrate Ceramic, and its role in strengthening and toughening this kind of ceramic composite. The alumina powder size-mass distribution was obtained by BI-XDC powder size analysis device; the open pore parameters of alumina adobe and sintered body were analyzed using the mercury pressure method. Their fracture surfaces were observed under scanning electronic microscope. Fine powder had two main size groups of 0.09-0.1 micron and 0.2-0.5 micron, respectively, and coarse powder, with size between 1.5 to 4.5 microns, occupied the majority of powder mass. Alumina adobe's pores became larger after sintering. The median pore radii of adobe and sintered body were 0.2531 micron and 0.3081 micron, respectively; the average pore radii changed from 0.0956 micron to 0.1102 micron. Under scanning electronic microscope, fine alumina powders were fused partially together and their surfaces were blunted, but coarse powders did not show such phenomena. The alumina size distribution contributes to the formation of porous structure of alumina sintered body. This porous structure is not only the shape skeleton but also the mechanical skeleton of GI-II Infiltrated Ceramic. It plays an important role in raising the mechanical properties of this kind of ceramic composite.

  18. Enabling the development of Community Extensions to GI-cat - the SIB-ESS-C case study

    Science.gov (United States)

    Bigagli, L.; Meier, N.; Boldrini, E.; Gerlach, R.

    2009-04-01

    GI-cat is a Java software package that implements discovery and access services for disparate geospatial resources. An instance of GI-cat provides a single point of service for querying and accessing remote, as well as local, heterogeneous sources of geospatial information, either through standard interfaces, or taking advantage of GI-cat advanced features, such as incremental responses, query feedback, etc. GI-cat supports a number of de-iure and de-facto standards, but can also be extended to additional community catalog/inventory services, by defining appropriate mediation components. The GI-cat and the SIB-ESS-C development teams collaborated in the development of a mediator to the Siberian Earth Science System Cluster (SIB-ESS-C), a web-based infrastructure to support the communities of environmental and Earth System research in Siberia. This activity resulted in the identification of appropriate technologies and internal mechanisms supporting the development of GI-cat extensions, that are the object of this work. GI-cat is actually built up of a modular framework of SOA components, that can be variously arranged to fit the needs of a community of users. For example, a particular GI-cat instance may be configured to provide discovery functionalities onto an OGC WMS; or to adapt a THREDDS catalog to the standard OGC CSW interface; or to merge a number of CDI repositories into a single, more efficient catalog. The flexibility of GI-cat framework is achieved thanks to its design, that follows the Tree of Responsibility (ToR) pattern and the Uniform Pipe and Filter architectural style. This approach allows the building of software blocks that can be flexibly reused and composed in multiple ways. In fact, the components that make up any GI-cat configuration all implement two common interfaces (i.e. IChainNode and ICatalogService), that support chaining one component to another . Hence, it would suffice to implement those interfaces (plus an appropriate factory

  19. Reduction of snapshots for MIMO radar detection by block/group orthogonal matching pursuit

    KAUST Repository

    Ali, Hussain El Hosiny

    2014-10-01

    Multiple-input multiple-output (MIMO) radar works on the principle of transmission of independent waveforms at each element of its antenna array and is widely used for surveillance purposes. In this work, we investigate MIMO radar target localization problem with compressive sensing. Specifically, we try to solve the problem of estimation of target location in MIMO radar by group and block sparsity algorithms. It will lead us to a reduced number of snapshots required and also we can achieve better radar resolution. We will use group orthogonal matching pursuit (GOMP) and block orthogonal matching pursuit (BOMP) for our problem. © 2014 IEEE.

  20. Dynamic contrast-enhanced perfusion studies of the brain with snapshot FLASH

    International Nuclear Information System (INIS)

    Finelli, D.A.; Kiefer, B.; Deimling, M.; Loeffler, W.; Haase, A.; Schuierer, G.

    1989-01-01

    This paper discusses how MR imaging with Gd-DTPA can improve the diagnostic accuracy of brain examinations. Conventional T1-weighted spin-echo sequences have been most satisfactory for depicting lesion enhancement following Gd-DTPA administration, however, the ability to examine the blood pool and early biodistribution phases has been limited. A new ultrafast MR imaging technique called Snapshot FLASH allows one to acquire entire images in 125-900 msec, with strong T1- or T2-weighted contrast. With this imaging technique, one can observe differential perfusion to the gray matter, while matter, and brain lesions during the first seconds following Gd-DTPA administration

  1. Visual Snapshots of Intracellular Kinase Activity At The Onset of Mitosis

    Science.gov (United States)

    Dai, Zhaohua; Dulyaninova, Natalya G.; Kumar, Sanjai; Bresnick, Anne R.; Lawrence, David S.

    2007-01-01

    Summary Visual snapshots of intracellular kinase activity can be acquired with exquisite temporal control using a light-activatable (caged) sensor, thereby providing a means to interrogate enzymatic activity at any point during the cell division cycle. Robust protein kinase activity transpires just prior to, but not immediately following, nuclear envelope breakdown (NEB). Furthermore, kinase activity is required for progression from prophase into metaphase. Finally, the application of selective protein kinase C (PKC) inhibitors, in combination with the caged sensor, correlates the action of the PKC β isoform with subsequent NEB. PMID:18022564

  2. The Association Between the Use of the Education Benefits from the G.I. Bill and Veterans' Health.

    Science.gov (United States)

    Rumery, Zachary R; Patel, Nilam; Richard, Patrick

    2018-05-01

    There is limited knowledge on the impact of education on veterans' health in the United States. This study specifically examines the relationship between the education benefits from the G.I. Bill and veterans' health. This study used data from the 2010 National Survey of Veterans. The subjects for this study were 5,052 veterans who were eligible to receive G.I. Bill benefits, representing a total of about 12.7 million non-institutionalized veterans in the United States in 2010. The dependent variables included self-reported health status and smoking behavior. The key independent variable was whether veterans used the education benefits from the G.I. Bill compared with those who were eligible but did not use them. Results from multivariate regression analyses showed that those who used the education benefits from the G.I. Bill were 4% less likely to report fair/poor health (p education benefits. Additional analyses showed that using the education benefits to attend college decreased the probability of being in fair/poor health by 4% (p benefits for non-college attainment such as business, technical, or vocational schools. More importantly, a larger association was found between the use of the education benefits from the G.I. Bill to obtain a college degree and fair/poor health (7%, p education also has important health benefits.

  3. A metagenomic snapshot of taxonomic and functional diversity in an alpine glacier cryoconite ecosystem

    International Nuclear Information System (INIS)

    Edwards, Arwyn; Pachebat, Justin A; Swain, Martin; Hegarty, Matt; Rassner, Sara M E; Hodson, Andrew J; Irvine-Fynn, Tristram D L; Sattler, Birgit

    2013-01-01

    Cryoconite is a microbe–mineral aggregate which darkens the ice surface of glaciers. Microbial process and marker gene PCR-dependent measurements reveal active and diverse cryoconite microbial communities on polar glaciers. Here, we provide the first report of a cryoconite metagenome and culture-independent study of alpine cryoconite microbial diversity. We assembled 1.2 Gbp of metagenomic DNA sequenced using an Illumina HiScanSQ from cryoconite holes across the ablation zone of Rotmoosferner in the Austrian Alps. The metagenome revealed a bacterially-dominated community, with Proteobacteria (62% of bacterial-assigned contigs) and Bacteroidetes (14%) considerably more abundant than Cyanobacteria (2.5%). Streptophyte DNA dominated the eukaryotic metagenome. Functional genes linked to N, Fe, S and P cycling illustrated an acquisitive trend and a nitrogen cycle based upon efficient ammonia recycling. A comparison of 32 metagenome datasets revealed a similarity in functional profiles between the cryoconite and metagenomes characterized from other cold microbe–mineral aggregates. Overall, the metagenomic snapshot reveals the cryoconite ecosystem of this alpine glacier as dependent on scavenging carbon and nutrients from allochthonous sources, in particular mosses transported by wind from ice-marginal habitats, consistent with net heterotrophy indicated by productivity measurements. A transition from singular snapshots of cryoconite metagenomes to comparative analyses is advocated. (letter)

  4. The Knowledge-about-Older-Patients - Quiz (KOP-Q) for nurses: Cross-cultural validation between the Netherlands and United States of America.

    Science.gov (United States)

    Dikken, Jeroen; Hoogerduijn, Jita G; Klaassen, Sharon; Lagerwey, Mary D; Shortridge-Baggett, Lillie; Schuurmans, Marieke J

    2017-08-01

    The Knowledge about Older Patients-Quiz (KOP-Q) is designed as a unidimensional scale measuring knowledge of hospital nurses about older patients. Furthermore, the KOP-Q measures a second unidimensional construct, certainty of hospital nurses about their knowledge. The KOP-Q is developed and validated in the Netherlands. Whether the KOP-Q can be used in other countries is unknown given the cultural and language differences. Investigate the level of measurement invariance of the KOP-Q between the Netherlands and United States of America (USA). A multicenter international cross-sectional design. Four general hospitals in the Netherlands and four general hospitals in the USA. Nurses from the Netherlands (n=201) and the USA (n=130) were invited to participate by email from the ward manager, distributing flyers and present messages on the online hospital communication boards. Questions of the KOP-Q were completed online. The level of measurement invariance (configural, metric or scalar invariance) across countries was tested by running increasingly constrained structural equation models, and testing whether these models fitted the data. Both the knowledge and certainty construct of the KOP-Q proved unidimensional in the Netherlands and USA sample. Test results of the measurement invariance across the Netherlands and USA indicated a stable, partial scalar invariance (15 items full scalar invariance) for the knowledge items and full scalar invariance for the certainty items. The KOP-Q shows to function uniformly across both language groups and can therefore be used to assess nurses' knowledge and their certainty about this knowledge which can be important for educational and/or quality improvement programs in the USA. Furthermore, the KOP-Q is suitable to make comparisons between the Netherlands and the USA using latent variable models. Before the KOP-Q can be used in other countries, cross-cultural tests should again be performed. Copyright © 2017 Elsevier Ltd. All

  5. Mean time for the development of large workloads and large queue lengths in the GI/G/1 queue

    Directory of Open Access Journals (Sweden)

    Charles Knessl

    1996-01-01

    Full Text Available We consider the GI/G/1 queue described by either the workload U(t (unfinished work or the number of customers N(t in the system. We compute the mean time until U(t reaches excess of the level K, and also the mean time until N(t reaches N0. For the M/G/1 and GI/M/1 models, we obtain exact contour integral representations for these mean first passage times. We then compute the mean times asymptotically, as K and N0→∞, by evaluating these contour integrals. For the general GI/G/1 model, we obtain asymptotic results by a singular perturbation analysis of the appropriate backward Kolmogorov equation(s. Numerical comparisons show that the asymptotic formulas are very accurate even for moderate values of K and N0.

  6. Therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells on the radiation-induced GI syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Shim, Se Hwan; Jang, Won Suk; Lee, Sun Joo; Park, Eun Young; Kim, Youn Joo; Jin, Sung Ho; Park, Sun Hoo; Lee, Seung Sook [Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)

    2011-05-15

    The gastrointestinal (GI) tract is one of the most radiosensitive organ systems in the body. Radiation-induced GI injury is described as destruction of crypt cell, decrease in villous height and number, ulceration, and necrosis of intestinal epithelium. Studies show that mesenchymal stem cells (MSCs) treatment may be useful in the repair or regeneration of damaged organs including bone, cartilage, or myocardium. MSCs from umbilical cord blood (UCB) have many advantages because of the immature nature of newborn cells compared to bone marrow derived MSCs. Moreover, UCB-MSCs provide no ethical barriers for basic studies and clinical applications. In this study, we explore the regeneration capability of human UCB-MSCs after radiation-induced GI injury

  7. On the GI/M/1 Queue with Vacations and Multiple Service Phases

    Directory of Open Access Journals (Sweden)

    Jianjun Li

    2017-01-01

    Full Text Available This paper considers a GI/M/1 queue with vacations and multiple service phases. Whenever the system becomes empty, the server takes a vacation, causing the system to move to vacation phase 0. If the server returns from a vacation to find no customer waiting, another vacation begins. Otherwise, the system jumps from phase 0 to some service phase i with probability qi,  i=1,2,…,N. Using the matrix geometric solution method and semi-Markov process, we obtain the distributions of the stationary system size at both arrival and arbitrary epochs. The distribution of the stationary waiting time of an arbitrary customer is also derived. In addition, we present some performance measures such as mean waiting time of an arbitrary customer, mean length of the type-i cycle, and mean number of customers in the system at the end of phase 0. Finally, some numerical examples are presented.

  8. "Üks mees nägi unes taevalikku õiglust..." : [luuletused] / Paul-Eerik Rummo

    Index Scriptorium Estoniae

    Rummo, Paul-Eerik, 1942-

    1998-01-01

    Sisu: "Üks mees nägi unes taevalikku õiglust..." ; "Plangusakkidel rõhtne laud..." ; "Sünnipärane tarkus - täpselt niipalju..." ; "Kusagil tuksub süda. Ei kellelegi, ei millelegi..." ; Vaade ; Vihma maitsest ; *** ; Esimene vasikas ; Laul kohmakast kromanjoonlasest ; Mõistmisest ; "Ükskord ennepuiste oli kuningriik, kus kõik oli puust..." ; Mäng ; "Koer oli ketis aiateibas..." ; Hamlet laulud 1-2 ; Kaudu mu vaevakaskede ; "Ma seisan mesilastaruna..." ; "Me hoiame nõnda ühte..." ; "Siin olen kasvanud. Tasasel maal..." ; Ikka Liivist mõteldes 1-2 ; Palmipuud ümber istutades laulda ; "Jah ma nägin lumevalgust..." ; "Oo et sädemeid kiljuks mu hing..." ; Maarjaheina kõrreke

  9. Investigations on the discrete Gi(G)1 queue with and without loss

    International Nuclear Information System (INIS)

    Gergely, T.; Toeroek, T.L.

    1975-12-01

    A comprehensive discussion of the method for investigating queuing systems characterized by random variables of integer values is given. Specially the discrete GI(G)1 queuing systems are considered. The first part of the paper takes a short summary on the theory of discrete stochastic processes. In the second part the properties of the fundamental characteristics of the queuing system as the busy period, the waiting time and the output processes are discussed. In the last section some remarks are added to show the direction of further investigations. To demonstrated the simplicity of the relations verified in the paper some computed examples are presented in the appendix. The computations were performed with a mini-computer of 8K words memory. (Sz.Z.)

  10. Partner-Assisted Emotional Disclosure for Patients with GI Cancer: Results from a Randomized Controlled Trial

    Science.gov (United States)

    Porter, Laura S.; Keefe, Francis J.; Baucom, Donald H.; Hurwitz, Herbert; Moser, Barry; Patterson, Emily; Kim, Hong Jin

    2009-01-01

    Background For patients with cancer who are married or in an intimate relationship, their relationships with their partners play a critical role in their adaptation to their illness. However, cancer patients and their partners often have difficulty in talking with each other about their cancer-related concerns. Difficulties in communication may ultimately compromise both the patient-partner relationship and the patient's psychological adjustment. The present study tested the efficacy of a novel partner-assisted emotional disclosure intervention in a sample of patients with gastrointestinal (GI) cancer. Methods 130 patients with GI cancer and their partners were randomly assigned to receive four sessions of either partner-assisted emotional disclosure or a couples cancer education/support intervention. Patients and partners completed measures of relationship quality, intimacy with their partner, and psychological distress before randomization and at the end of the intervention sessions. Data were analyzed using multilevel modeling. Results Compared to an education/support condition, the partner-assisted emotional disclosure condition led to improvements in relationship quality and intimacy for couples in which the patient initially reported higher levels of holding back from discussing cancer-related concerns. Conclusions Partner-assisted emotional disclosure is a novel intervention that builds on both the private emotional disclosure and the cognitive-behavioral marital literature. The results of this study suggest that this intervention may be beneficial for couples in which the patient tends to hold back from discussing concerns. Future research on methods of enhancing the effects of partner-assisted emotional disclosure is warranted. PMID:19731357

  11. Insights into the evolution of the new variant rabbit haemorrhagic disease virus (GI.2) and the identification of novel recombinant strains.

    Science.gov (United States)

    Silvério, D; Lopes, A M; Melo-Ferreira, J; Magalhães, M J; Monterroso, P; Serronha, A; Maio, E; Alves, P C; Esteves, P J; Abrantes, J

    2018-02-11

    Rabbit haemorrhagic disease (RHD) is a viral disease that affects the European rabbit. RHD was detected in 1984 in China and rapidly disseminated worldwide causing a severe decline in wild rabbit populations. The aetiological agent, rabbit haemorrhagic disease virus (RHDV), is an RNA virus of the family Caliciviridae, genus Lagovirus. Pathogenic (G1-G6 or variants GI.1a-GI.1d) and non-pathogenic strains (GI.4) have been characterized. In 2010, a new variant of RHDV, RHDV2/RHDVb/GI.2, was detected in France. GI.2 arrived to the Iberian Peninsula in 2011, and several recombination events were reported. Here, we sequenced full genomes of 19 samples collected in Portugal between 2014 and 2016. New GI.2 recombinant strains were detected, including triple recombinants. These recombinants possess a non-structural protein p16 related to a non-pathogenic strain. Evolutionary analyses were conducted on GI.2 VP60 sequences. Estimated time to the most recent common ancestor (tMRCA) suggests an emergence of GI.2 in July 2008, not distant from its first detection in 2010. This is the first study on GI.2 evolution and highlights the need of continued monitoring and characterization of complete genome sequences when studying lagoviruses' evolution. © 2018 Blackwell Verlag GmbH.

  12. Texas, Rosie ja Helga KitKat Clubist : endised varieteestaarid Ülle Toming, Reet Paavel ja Laine Mägi astuvad taas lavale / Ülle Toming, Reet Paavel, Laine Mägi ; interv. Verni Leivak

    Index Scriptorium Estoniae

    Toming, Ülle, 1955-

    2003-01-01

    Vanalinnastuudio muusikal "Cabaret". Intervjuu omaaegsete varieteetähtedega: Laine Mägi, Ülle Toming ja Reet Paavel moodustavad muusikalis "Cabaret" osa koorist, kel tuleb üle hulga aja laulda, tantsida ja näidelda väga erinevates rollides. Lisaks nende tutvustus "Kolm graatsiat"

  13. A Little More Madness in Our Methods? A Snapshot of How the Educational Leadership, Management and Administration Field Conducts Research

    Science.gov (United States)

    Thomson, Pat

    2017-01-01

    The field of educational leadership, management and administration (ELMA) uses methods drawn primarily from cognate educational disciplines. But does this matter? This paper explores the methods used in recently published papers through a snapshot of six issues of six ELMA journals. The analysis showed a preponderance of survey, interview and case…

  14. Energy Transition Initiative: Island Energy Snapshot - Haiti; U.S. Department of Energy (DOE), NREL (National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-06-01

    This profile provides a snapshot of the energy landscape of Haiti, an independent nation that occupies the western portion of the island of Hispaniola in the northern Caribbean Sea. Haiti’s utility rates are roughly $0.35 U.S. dollars (USD) per kilowatt-hour (kWh), above the Caribbean regional average of $0.33 USD/kWh.

  15. The Nation's Report Card Reading 2009 Trial Urban District Snapshot Report. Austin Independent School District. Grade 8, Public Schools

    Science.gov (United States)

    National Center for Education Statistics, 2010

    2010-01-01

    Each district that participated in the National Assessment of Educational Progress (NAEP) 2009 Trial Urban District Assessment in reading receives a one-page snapshot report that presents key findings and trends in a condensed format. This report presents the results for Austin Independent School District's student achievement in reading. In 2009,…

  16. The Nation's Report Card Reading 2009 Trial Urban District Snapshot Report. Austin Independent School District. Grade 4, Public Schools

    Science.gov (United States)

    National Center for Education Statistics, 2010

    2010-01-01

    Each district that participated in the National Assessment of Educational Progress (NAEP) 2009 Trial Urban District Assessment in reading receives a one-page snapshot report that presents key findings and trends in a condensed format. This report presents the results for Austin Independent School District's student achievement in reading. In 2009,…

  17. CC-MUSIC: An Optimization Estimator for Mutual Coupling Correction of L-Shaped Nonuniform Array with Single Snapshot

    Directory of Open Access Journals (Sweden)

    Yuguan Hou

    2015-01-01

    Full Text Available For the case of the single snapshot, the integrated SNR gain could not be obtained without the multiple snapshots, which degrades the mutual coupling correction performance under the lower SNR case. In this paper, a Convex Chain MUSIC (CC-MUSIC algorithm is proposed for the mutual coupling correction of the L-shaped nonuniform array with single snapshot. It is an online self-calibration algorithm and does not require the prior knowledge of the correction matrix initialization and the calibration source with the known position. An optimization for the approximation between the no mutual coupling covariance matrix without the interpolated transformation and the covariance matrix with the mutual coupling and the interpolated transformation is derived. A global optimization problem is formed for the mutual coupling correction and the spatial spectrum estimation. Furthermore, the nonconvex optimization problem of this global optimization is transformed as a chain of the convex optimization, which is basically an alternating optimization routine. The simulation results demonstrate the effectiveness of the proposed method, which improve the resolution ability and the estimation accuracy of the multisources with the single snapshot.

  18. Energy Transition Initiative: Island Energy Snapshot - Bonaire; U.S. Department of Energy (DOE), NREL (National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-06-01

    This profile provides a snapshot of the energy landscape of Bonaire, a special municipality of the Kingdom of the Netherlands located off the coast of Venezuela. Bonaire’s utility rates are approximately $0.35 per kilowatt-hour (kWh), above the Caribbean regional average of $0.33/kWh.

  19. Energy Transition Initiative: Island Energy Snapshot - San Andres and Providencia (Fact Sheet); NREL(National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-03-01

    This profile provides a snapshot of the energy landscape of the Archipelago of San Andres, Providencia, and Santa Catalina (unpopulated), also known as San Andres and Providencia, which is equidistant between Costa Rica and Jamaica and 775 kilometers northwest of Colombia. The archipelago is part of Colombia, though Nicaragua has also laid claim to it.

  20. A Snapshot of Gender in Brazil Today : Institutions, Outcomes, and a Closer Look at Racial and Geographic Differences

    OpenAIRE

    Gukovas, Renata; Muller, Miriam; Pereira, Ana Claudia; Reimao, Maira Emy

    2016-01-01

    The Gender Diagnostic: ‘A Snapshot of Gender in Brazil Today: Institutions, Outcomes, and a Closer Look at Racial and Geographic Differences Gender issues in Brazil’ highlights progress on gender equality in the country and lays out the main areas of persisting challenges. It details gender outcomes beyond the national aggregate and emphasizes that gender inequality in Brazil has to be und...

  1. Energy Transition Initiative: Island Energy Snapshot - Curacao; U.S. Department of Energy (DOE), NREL (National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-06-01

    This profile provides a snapshot of the energy landscape of Curacao, an autonomous member of the Kingdom of the Netherlands located off the coast of Venezuela. Curacao’s utility rates are approximately $0.26 per kilowatt-hour (kWh), below the Caribbean regional average of $0.33/kWh.

  2. Low-complexity DOA estimation from short data snapshots for ULA systems using the annihilating filter technique

    Science.gov (United States)

    Bellili, Faouzi; Amor, Souheib Ben; Affes, Sofiène; Ghrayeb, Ali

    2017-12-01

    This paper addresses the problem of DOA estimation using uniform linear array (ULA) antenna configurations. We propose a new low-cost method of multiple DOA estimation from very short data snapshots. The new estimator is based on the annihilating filter (AF) technique. It is non-data-aided (NDA) and does not impinge therefore on the whole throughput of the system. The noise components are assumed temporally and spatially white across the receiving antenna elements. The transmitted signals are also temporally and spatially white across the transmitting sources. The new method is compared in performance to the Cramér-Rao lower bound (CRLB), the root-MUSIC algorithm, the deterministic maximum likelihood estimator and another Bayesian method developed precisely for the single snapshot case. Simulations show that the new estimator performs well over a wide SNR range. Prominently, the main advantage of the new AF-based method is that it succeeds in accurately estimating the DOAs from short data snapshots and even from a single snapshot outperforming by far the state-of-the-art techniques both in DOA estimation accuracy and computational cost.

  3. FELIX: an algorithm for indexing multiple crystallites in X-ray free-electron laser snapshot diffraction images

    DEFF Research Database (Denmark)

    Beyerlein, Kenneth R.; White, Thomas A.; Yefanov, Oleksandr

    2017-01-01

    A novel algorithm for indexing multiple crystals in snapshot X-ray diffraction images, especially suited for serial crystallography data, is presented. The algorithm, FELIX, utilizes a generalized parametrization of the Rodrigues-Frank space, in which all crystal systems can be represented without...

  4. Energy Transition Initiative: Island Energy Snapshot - Palau; U.S. Department of Energy (DOE), NREL (National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-06-01

    This profile provides a snapshot of the energy landscape of Palau, an independent island nation geographically located in the Micronesia region. Palau’s residential electricity rates are approximately $0.28 U.S. dollars (USD) per kilowatt-hour (kWh), more than twice the average U.S. residential rate of $0.13 USD/kWh.

  5. Experimental infection of calves with a gI, gE, US9 negative bovine herpesvirus type 5

    NARCIS (Netherlands)

    Hubner, S.O.; Oliveira, A.P.; Franco, A.C.; Rijsewijk, F.A.M.; Roehe, P.M.

    2005-01-01

    In this work, a role for the genes encoding glycoproteins I (gI) and E (gE) and the US9 protein of bovine herpesvirus type 5 (BHV-5) in neuropathogenicity and reactivation of latent infections was examined. Calves infected intranasally with a gI/gE/US9 deleted recombinant shed up to 102.85 TCID50/ml

  6. Kas erivajadustega lapsed saavad õigel ajal abi? / Ene Mägi, Urve Raudsepp-Alt, Ale Sprenk, Peeter Aas

    Index Scriptorium Estoniae

    2009-01-01

    Küsimusele vastavad: Tallinna Ülikooli Kasvatusteaduste Instituudi eri- ja sotsiaalpedagoogika osakonna juhataja Ene Mägi, Tallinna Haridusameti üldhariduse osakonna peaspetsialist Urve Raudsepp-Alt, Krabi põhikooli direktor Ale Sprenk, Põlva Maavalitsuse haridus-, kultuuri- ja sotsiaalosakonna juhataja Peeter Aas

  7. Maksuameti võimatu missioon / Lemmi Kann ; kommenteerinud Lasse Lehis, Rait Kaarma, Taavi Veskimägi

    Index Scriptorium Estoniae

    Kann, Lemmi

    2009-01-01

    Väljavõte artiklist: Maksude optimeerijad tõmmatakse liistule / Lemmi Kann (aripaev.ee, 17.03.2009). Kommenteerivad Eesti Maksumaksjate Liidu juhatuse esimees Lasse Lehis, Alvin, Rödl & Partner Advokaadibüroo OÜ advokaat Rait Kaarma ja Riigikogu liige Taavi Veskimägi

  8. Regio viib India vabad ja vallalised kokku / Teet Jagomägi ; interv. Toivo Tänavsuu

    Index Scriptorium Estoniae

    Jagomägi, Teet, 1969-

    2005-01-01

    Ettevõtluse auhinna Innovaator 2005 võitnud AS-i Regio juht Teet Jagomägi ettevõtte tegevusest ja arengusuundadest. Innovaator 2005 nominendid. Parimad innovatsioonid ettevõtetelt Cybernetica AS, Energiatehnika OÜ, OÜ Müomeetria, AS Regio ja Viru Õlitööstuse AS

  9. Autofluorescence endoscopy: feasibility of detection of GI neoplasms unapparent to white light endoscopy with an evolving technology

    NARCIS (Netherlands)

    Haringsma, J.; Tytgat, G. N.; Yano, H.; Iishi, H.; Tatsuta, M.; Ogihara, T.; Watanabe, H.; Sato, N.; Marcon, N.; Wilson, B. C.; Cline, R. W.

    2001-01-01

    Case studies are presented of fluorescence endoscopy in the upper and lower GI tract to illustrate the ability to detect early-stage lesions that were not observable with white light endoscopy or those in which the assessment of the stage or extension of the lesion were equivocal. A new fluorescence

  10. Mida kujutab endast IB õppekava? / Toomas Kruusimägi, Anu Parts, Karl Hendrik Thomson ; intervjueerinud Raivo Juurak

    Index Scriptorium Estoniae

    Kruusimägi, Toomas, 1962-

    2010-01-01

    Uuest rahvusvahelisest International Baccalaureate'i (IB) õppekavast ja selle rakendamisest Tallinna Inglise Kolledži 11. klassis alates möödunud aastast räägivad kooli direktor Toomas Kruusimägi, õppedirektor Anu Parts ning õpilane Karl Hendrik Thomson

  11. A heavy-traffic theorem for the GI/G/1 queue with a Pareto-type service time distribution

    NARCIS (Netherlands)

    J.W. Cohen

    1997-01-01

    textabstractFor the $GI/G/1$-queueing model with traffic load $a<1$, service time distribution $B(t)$ and interarrival time distribution $A(t)$ holds, whenever for $t rightarrow infty$: $$ quad 1-B(t) sim frac{c{(t/ beta)^nu + {rm O ( {rm e^{-delta t ), quad c>0, quad 1< nu < 2, quad delta >

  12. Demonstration of fully functional MIMO wireless LAN transmission over GI-MMF for in-building networks

    NARCIS (Netherlands)

    Zou, S.; Chen, H.; Huijskens, F.M.; Cao, Z.; Tangdiongga, E.; Koonen, A.M.J.

    2013-01-01

    We propose a low-cost optically-fed architecture capable of increasing the capacity and overall coverage of IEEE 802.11n MIMO WLAN system for in-building networks. A fully functional transmission over GI-MMF was demonstrated employing 2×3 MIMO configuration.

  13. MELATONIN-INDUCED SUPPRESSION OF PC12 CELL GROWTH IS MEDIATED BY ITS GI COUPLED TRANSMEMBRANE RECEPTORS. (R826248)

    Science.gov (United States)

    The effects of pertussis toxin, an uncoupler of Gi protein from adenylate cyclase, and luzindole, a competitive inhibitor of melatonin receptor binding, were examined for their ability to inhibit melatonin-induced suppression of PC12 cell growth. Both agents inhibited the mela...

  14. The utilisation and diagnostic yield of radiological imaging in a specialist functional GI disorder clinic: an 11-year retrospective study.

    LENUS (Irish Health Repository)

    Breen, Micheal

    2014-07-25

    The term functional gastrointestinal disorders (FGID) describes various aggregations of chronic gastrointestinal (GI) symptoms not explained by identifiable organic pathology; accordingly, their diagnosis rests on symptom-based criteria and a process of exclusion. Evidence is lacking on the appropriate use of abdominal imaging studies (AIS) in FGIDs.

  15. Jüri Nael ristas Nietzsche ja Mägi / Jüri Nael ; interv. Andri Maimets

    Index Scriptorium Estoniae

    Nael, Jüri, 1975-

    2004-01-01

    Detsembri algul esietendus Londonis Bonnie Birdi teatris koreograaf J. Naela autorilavastus "Kell näitabki juba täpset aega. Millist?" Monoetenduse esitaja on L. Mägi ja muusikaline kujundaja M. Mattiesen. Lisatud Labani akadeemia pedagoogi dr. Valerie Preston-Dunlopi arvamus

  16. The soil microbiome at the Gi-FACE experiment responds to a moisture gradient but not to CO2 enrichment.

    Science.gov (United States)

    de Menezes, Alexandre B; Müller, Christoph; Clipson, Nicholas; Doyle, Evelyn

    2016-09-01

    The soil bacterial community at the Giessen free-air CO2 enrichment (Gi-FACE) experiment was analysed by tag sequencing of the 16S rRNA gene. No substantial effects of CO2 levels on bacterial community composition were detected. However, the soil moisture gradient at Gi-FACE had a significant effect on bacterial community composition. Different groups within the Acidobacteria and Verrucomicrobia phyla were affected differently by soil moisture content. These results suggest that modest increases in atmospheric CO2 may cause only minor changes in soil bacterial community composition and indicate that the functional responses of the soil community to CO2 enrichment previously reported at Gi-FACE are due to factors other than changes in bacterial community composition. The effects of the moisture gradient revealed new information about the relationships between poorly known Acidobacteria and Verrucomicrobia and soil moisture content. This study contrasts with the relatively small number of other temperate grassland free-air CO2 enrichment microbiome studies in the use of moderate CO2 enrichment and the resulting minor changes in the soil microbiome. Thus, it will facilitate the development of further climate change mitigation studies. In addition, the moisture gradient found at Gi-FACE contributes new knowledge in soil microbial ecology, particularly regarding the abundance and moisture relationships of the soil Verrucomicrobia.

  17. Identifying strategic sites for Green-Infrastructures (GI) to manage stormwater in a miscellaneous use urban African watershed

    Science.gov (United States)

    Selker, J. S.; Kahsai, S. K.

    2017-12-01

    Green Infrastructure (GI) or Low impact development (LID), is a land use planning and design approach with the objective of mitigating land development impacts to the environment, and is ever more looked to as a way to lessen runoff and pollutant loading to receiving water bodies. Broad-scale approaches for siting GI/LID have been developed for agricultural watersheds, but are rare for urban watersheds, largely due to greater land use complexity. And it is even more challenging when it comes to Urban Africa due to the combination of poor data quality, rapid and unplanned development, and civic institutions unable to reliably carry out regular maintenance. We present a spacio-temporal simulation-based approach to identify an optimal prioritization of sites for GI/LID based on DEM, land use and land cover. Optimization used is a multi-objective optimization tool along with an urban storm water management model (SWMM) to identify the most cost-effective combination of LID/GI. This was applied to an urban watershed in NW Kampala, Lubigi Catchment (notorious for being heavily flooded every year), with a miscellaneous use watershed in Uganda, as a case-study to demonstrate the approach.

  18. Per preparare la ripresa: Progetto europeo GI-N2K, “Geographic Information – Need to Know”

    Directory of Open Access Journals (Sweden)

    Mauro Salvemini

    2014-02-01

    Full Text Available The GI-N2K project, coordinated by the Katholieke Universiteit Leuven, which began in October 2013, and formed by an international consortium of 31 partners (25  countries is funded by the Erasmus Lifelong Learning Programme, aims to reformulate  the Body of Knowledge in the field of Geographic Information Science and  Technology.

  19. Detection and localization of acute upper and lower gastrointestinal (GI) bleeding with arterial phase multi-detector row helical CT

    Energy Technology Data Exchange (ETDEWEB)

    Jaeckle, T.; Stuber, G.; Hoffmann, M.H.K.; Jeltsch, M.; Schmitz, B.L.; Aschoff, A.J. [University Hospital of Ulm, Diagnostic and Interventional Radiology, Ulm (Germany)

    2008-07-15

    The purpose of this study was to evaluate the accuracy of multi-detector row helical CT (MDCT) for detection and localization of acute upper and lower gastrointestinal (GI) hemorrhage or intraperitoneal bleeding. Thirty-six consecutive patients with clinical signs of acute bleeding underwent biphasic (16- or 40-channel) MDCT. MDCT findings were correlated with endoscopy, angiography or surgery. Among the 36 patients evaluated, 26 were examined for GI bleeding and 10 for intraperitoneal hemorrhage. Confirmed sites of GI bleeding were the stomach (n = 5), duodenum (n = 5), small bowel (n = 6), large bowel (n = 8) and rectum (n = 2). The correct site of bleeding was identifiable on MDCT in 24/26 patients with GI bleeding. In 20 of these 24 patients, active CM extravasation was apparent during the exam. Among the ten patients with intraperitoneal hemorrhage, MDCT correctly identified the bleeding source in nine patients. Our findings suggest that fast and accurate localization of acute gastrointestinal and intraperitoneal bleeding is achievable on MDCT. (orig.)

  20. Detection and localization of acute upper and lower gastrointestinal (GI) bleeding with arterial phase multi-detector row helical CT

    International Nuclear Information System (INIS)

    Jaeckle, T.; Stuber, G.; Hoffmann, M.H.K.; Jeltsch, M.; Schmitz, B.L.; Aschoff, A.J.

    2008-01-01

    The purpose of this study was to evaluate the accuracy of multi-detector row helical CT (MDCT) for detection and localization of acute upper and lower gastrointestinal (GI) hemorrhage or intraperitoneal bleeding. Thirty-six consecutive patients with clinical signs of acute bleeding underwent biphasic (16- or 40-channel) MDCT. MDCT findings were correlated with endoscopy, angiography or surgery. Among the 36 patients evaluated, 26 were examined for GI bleeding and 10 for intraperitoneal hemorrhage. Confirmed sites of GI bleeding were the stomach (n = 5), duodenum (n = 5), small bowel (n = 6), large bowel (n = 8) and rectum (n = 2). The correct site of bleeding was identifiable on MDCT in 24/26 patients with GI bleeding. In 20 of these 24 patients, active CM extravasation was apparent during the exam. Among the ten patients with intraperitoneal hemorrhage, MDCT correctly identified the bleeding source in nine patients. Our findings suggest that fast and accurate localization of acute gastrointestinal and intraperitoneal bleeding is achievable on MDCT. (orig.)

  1. Fast high-resolution MR imaging using the snapshot-FLASH MR sequence

    International Nuclear Information System (INIS)

    Matthaei, D.; Haase, A.; Henrich, D.; Duhmke, E.

    1990-01-01

    Snapshot, fast low-angle short (FLASH) MR imaging using an accelerated FLASH-MR sequence provides MR images with measuring times far below 1 second. The short TE of this sequence prevents susceptibility artifacts in gradient-echo imaging. In this paper variations of the sequence are shown that provide high resolution images with T1-weighted IR, T2-weighted SE, and chemical shift (CHESS) contrast sequences. METHODS AND MATERIALS: A whole-body 2-T system (Bruker-Medizintechnik) were used in combination with a 60-cm gradient system (providing gradient strength of 5 mT/m) to study healthy volunteers. The measuring time for a 256 x 256 image matrix was 800 msec. This sequence has been used in combination with T1-weighted IR, T2-weighted SE, and CHESS variations

  2. Snapshots of the Past, by Brian Fagan. Alta Mira Press (Sage Publications. Walnut Creek, CA, 1995

    Directory of Open Access Journals (Sweden)

    Todd W. Bostwick

    1997-05-01

    Full Text Available Brian Fagan is well known for his archaeology books written for a general public as well as his textbooks. This book is a collection of his articles originally published as bimonthly 'Timelines' columns in Archaeol­ogy Magazine. As he states in the preface of the book, his articles were meant to entertain, inform and sometimes wax indignant on a wide variety of archaeological subjects. His intent was to make available to a wide audience short stories that "navigated through the maze of detailed and specialized literature, creating snapshots of archaeology, archaeologists, and our complex, multifaceted past." The collection of 27 articles he chose for the book were published between 1988 and 1995; in addition, Fagan wrote two new articles for the book (one on prehistoric art and the other on the lives of Egyptian townspeople, for a total 29 articles.

  3. Answer to neuroimaging quiz case

    African Journals Online (AJOL)

    2016-04-05

    Apr 5, 2016 ... hemisphere in the area of concern. The central vessel is noted as a ... of a solitary large focus of cerebral demyelination with an appearance that mimics a ... of the ring usually lies along the grey matter interface of the lesion.

  4. Exercise-Induced Bronchoconstriction Quiz

    Science.gov (United States)

    ... a world class swimmer who won six Olympic gold medals. Question 6 Even if I used my ... infection, temperatures are low, or pollen and air pollution levels are high. Learn more about asthma symptoms, ...

  5. Exercise-Induced Bronchoconstriction Quiz

    Science.gov (United States)

    ... Conditions Drug Guide Conditions Dictionary Just for Kids Library School Tools Videos Virtual Allergist Education & Training Careers in ... Support the AAAAI Foundation Donate Utility navigation Español Journals Annual Meeting Member Login / My Membership Search navigation ...

  6. A snapshot of radiation therapy techniques and technology in Queensland: An aid to mapping undergraduate curriculum

    International Nuclear Information System (INIS)

    Bridge, Pete; Carmichael, Mary-Ann; Brady, Carole; Dry, Allison

    2013-01-01

    Undergraduate students studying the Bachelor of Radiation Therapy at Queensland University of Technology (QUT) attend clinical placements in a number of department sites across Queensland. To ensure that the curriculum prepares students for the most common treatments and current techniques in use in these departments, a curriculum matching exercise was performed. A cross-sectional census was performed on a pre-determined “Snapshot” date in 2012. This was undertaken by the clinical education staff in each department who used a standardized proforma to count the number of patients as well as prescription, equipment, and technique data for a list of tumour site categories. This information was combined into aggregate anonymized data. All 12 Queensland radiation therapy clinical sites participated in the Snapshot data collection exercise to produce a comprehensive overview of clinical practice on the chosen day. A total of 59 different tumour sites were treated on the chosen day and as expected the most common treatment sites were prostate and breast, comprising 46% of patients treated. Data analysis also indicated that intensity-modulated radiotherapy (IMRT) use is relatively high with 19.6% of patients receiving IMRT treatment on the chosen day. Both IMRT and image-guided radiotherapy (IGRT) indications matched recommendations from the evidence. The Snapshot method proved to be a feasible and efficient method of gathering useful data to inform curriculum matching. Frequency of IMRT use in Queensland matches or possibly exceeds that indicated in the literature. It is recommended that future repetition of the study be undertaken in order to monitor trends in referral patterns and new technology implementation

  7. A snapshot of radiation therapy techniques and technology in Queensland: An aid to mapping undergraduate curriculum

    Energy Technology Data Exchange (ETDEWEB)

    Bridge, Pete; Carmichael, Mary-Ann [School of Clinical Sciences, Queensland University of Technology, Brisbane, Queensland, 4001 (Australia); Brady, Carole [Radiation Oncology Mater Centre, Raymond Terrace, South Brisbane, Queensland, 4101 (Australia); Dry, Allison [Cancer Care Services Royal Brisbane Women' s Hospital Herston, Brisbane, Queensland, 4029 (Australia); School of Clinical Sciences, Queensland University of Technology, Brisbane, Queensland, 4001 (Australia)

    2013-03-15

    Undergraduate students studying the Bachelor of Radiation Therapy at Queensland University of Technology (QUT) attend clinical placements in a number of department sites across Queensland. To ensure that the curriculum prepares students for the most common treatments and current techniques in use in these departments, a curriculum matching exercise was performed. A cross-sectional census was performed on a pre-determined “Snapshot” date in 2012. This was undertaken by the clinical education staff in each department who used a standardized proforma to count the number of patients as well as prescription, equipment, and technique data for a list of tumour site categories. This information was combined into aggregate anonymized data. All 12 Queensland radiation therapy clinical sites participated in the Snapshot data collection exercise to produce a comprehensive overview of clinical practice on the chosen day. A total of 59 different tumour sites were treated on the chosen day and as expected the most common treatment sites were prostate and breast, comprising 46% of patients treated. Data analysis also indicated that intensity-modulated radiotherapy (IMRT) use is relatively high with 19.6% of patients receiving IMRT treatment on the chosen day. Both IMRT and image-guided radiotherapy (IGRT) indications matched recommendations from the evidence. The Snapshot method proved to be a feasible and efficient method of gathering useful data to inform curriculum matching. Frequency of IMRT use in Queensland matches or possibly exceeds that indicated in the literature. It is recommended that future repetition of the study be undertaken in order to monitor trends in referral patterns and new technology implementation.

  8. Niezamknięte księgi – o księgach cechowych na Pomorzu Zachodnim

    Directory of Open Access Journals (Sweden)

    Agnieszka Pawłowska

    2010-01-01

    Full Text Available Niniejsze badanie koncentruje się na księgach powstałych w wyniku działalności organizacji cechowych na Pomorzu Zachodnim. Jest to specyficzny rodzaj zabytków, w których odzwierciedla się życie zarówno zawodowe, jak i społeczne oraz towarzyskie korporacji. Pisane były niejednokrotnie przez kolejne pokolenia, obejmują nawet kilka stuleci, przez co stanowią cenne źródło historyczne. Księgi dzieliły się na urzędowe, obejmujące całokształt działalności (Amtsbuch, oraz wyspecjalizowane – księgi protokołów (Protokollbuch, księgi mistrzów, czeladników i uczniów (Meister-, Gesellen- i Lehrjungenbuch, księgi rachunkowe (Rechnungsbuch i księgi normatywne. Tekst ukazuje znaczną różnorodność kwestii poruszanych w poszczególnych rodzajach ksiąg, a także ich formę zewnętrzną. Podstawę do badań stanowią obiekty przechowywane w Archiwum Państwowym w Szczecinie. Daleko posunięte podobieństwo w funkcjonowaniu cechów poza granicami Pomorza pozwala na przeniesienie wniosków również na inne organizacje cechowe.

  9. Rabbit haemorrhagic disease virus 2 (GI.2) is replacing endemic strains of RHDV in the Australian landscape within 18 months of its arrival.

    Science.gov (United States)

    Mahar, Jackie E; Hall, Robyn N; Peacock, David; Kovaliski, John; Piper, Melissa; Mourant, Roslyn; Huang, Nina; Campbell, Susan; Gu, Xingnian; Read, Andrew; Urakova, Nadya; Cox, Tarnya; Holmes, Edward C; Strive, Tanja

    2017-11-01

    Rabbit haemorrhagic disease virus 2 (RHDV2; Lagovirus GI.2) is a pathogenic calicivirus that affects European rabbits ( Oryctolagus cuniculus ) and various hare ( Lepus ) species. GI.2 was first detected in France in 2010 and subsequently caused epidemics in wild and domestic lagomorph populations throughout Europe. In May 2015 GI.2 was detected in Australia. Within 18 months of its initial detection GI.2 had spread to all Australian states and territories and rapidly became the dominant circulating strain, replacing Rabbit haemorrhagic disease virus (RHDV/GI.1) in mainland Australia. Reconstruction of the evolutionary history of 127 Australian GI.2 isolates revealed that the virus arrived in Australia at least several months before its initial description and likely circulated unnoticed in wild rabbit populations in the east of the continent prior to its detection. GI.2 sequences isolated from five hares clustered with sequences from sympatric rabbit populations sampled contemporaneously, indicating multiple spillover events into hares rather than an adaptation of the Australian GI.2 to a new host. Since the presence of GI.2 in Australia may have wide ranging consequences for rabbit biocontrol, particularly with the release of the novel biocontrol agent GI.1a/RHDVa-K5 in March 2017, ongoing surveillance is critical to understanding the interactions of the various lagoviruses in Australia, and their impact on host populations. IMPORTANCE This study describes the spread and distribution of Rabbit Haemorrhagic Disease virus 2 (GI.2) in Australia since its first detection in May 2015. Within the first 18 months following its detection, RHDV2 spread from east to west across the continent and became the dominant strain in all mainland states of Australia. This has important implications for pest animal management and for owners of pet and farmed rabbits, as there is currently no effective vaccine available in Australia for GI.2. The closely related RHDV (GI.1) is used

  10. The impact of GI events on persistence and adherence to osteoporosis treatment: 3-, 6-, and 12-month findings in the MUSIC-OS study.

    Science.gov (United States)

    Modi, A; Sen, S; Adachi, J D; Adami, S; Cortet, B; Cooper, A L; Geusens, P; Mellström, D; Weaver, J P; van den Bergh, J P; Keown, P; Sajjan, S

    2018-02-01

    The goal of this multinational, prospective, observational study was to examine the relationship between gastrointestinal (GI) events and self-reported levels of medication adherence and persistence in postmenopausal women. A total of 73.9% of patients remained on their osteoporosis (OP) therapy at month 12, although the presence of a GI event at baseline, month 3, and month 6 significantly reduced month 12 persistence among new users. The odds of a month-12 ADEOS score ≥ 20 were significantly lower among patients who experienced a GI event between baseline and month 6. The occurrence of GI events was observed to be associated with a lower likelihood of patient adherence and persistence to OP medication. This study examines the relationship between gastrointestinal (GI) events and self-reported adherence and persistence with initial osteoporosis (OP) therapy over the course of the first 12 months of treatment. The Medication Use Patterns, Treatment Satisfaction, and Inadequate Control of Osteoporosis Study was a multinational, prospective, observational study examining the impact of GI events on OP management in postmenopausal women. Information regarding GI events was collected at the time of enrollment and at months 3, 6, and 12 of follow-up. Patients reported GI events and medication persistence and completed the 12-item Adherence Evaluation of Osteoporosis treatment (ADEOS) questionnaire. Multivariate logistic and general linear models examined the association between GI events at various time points and persistence and adherence at month 12. The study enrolled 2943 women; 22.8% were classified as new users of OP therapy and the remainder were considered experienced users. Across all patients, 68.1% reported GI events at baseline; by month 12, over 80% of subjects who completed follow-up reported at least one GI problem. The majority of patients (86.7%) were treated only with bisphosphonates at baseline. At month 12, 73.9% of patients remained on therapy

  11. Waterborne gastroenteritis outbreak at a scouting camp caused by two norovirus genogroups: GI and GII.

    Science.gov (United States)

    ter Waarbeek, Henriëtte L G; Dukers-Muijrers, Nicole H T M; Vennema, Harry; Hoebe, Christian J P A

    2010-03-01

    A cross-border gastroenteritis outbreak at a scouting camp was associated with drinking water from a farmer's well. A retrospective cohort study was performed to identify size and source of the outbreak, as well as other characteristics. Epidemiological investigation included standardized questionnaires about sex, age, risk exposures, illness and family members. Stool and water (100mL) samples were analyzed for bacteria, viruses and parasites. Questionnaires were returned by 84 scouts (response rate 82%), mean age of 13 years. The primary attack rate was 85% (diarrhoea and/or vomiting). Drinking water was the strongest independent risk factor showing a dose-response effect with 50%, 75%, 75%, 93% and 96% case prevalence for 0, 1, 2-3, 4-5 and >5 glasses consumed, respectively. Norovirus (GI.2 Southampton and GII.7 Leeds) was detected in 51 stool specimens (75%) from ill scouts. Water analysis showed fecal contamination, but no norovirus. The secondary attack rate was 20%. This remarkable outbreak was caused by a point-source infection with two genogroups of noroviruses most likely transmitted by drinking water from a well. Finding a dose-response relationship was striking. Specific measures to reduce the risk of waterborne diseases, outbreak investigation and a good international public health network are important.

  12. A randomized pilot trial of a videoconference couples communication intervention for advanced GI cancer.

    Science.gov (United States)

    Porter, Laura S; Keefe, Francis J; Baucom, Donald H; Olsen, Maren; Zafar, S Yousuf; Uronis, Hope

    2017-07-01

    This study aims to test the feasibility and preliminary efficacy of a couple-based communication intervention for advanced GI cancer delivered via videoconference. Thirty-two couples were randomly assigned to either couples communication skills training (CCST) or an education comparison intervention, both delivered via videoconference. Participation was limited to couples who reported communication difficulties at screening. Patients and partners completed measures of relationship functioning and individual functioning at baseline and post-intervention. Eighty-eight percent of randomized dyads completed all six sessions and reported high levels of satisfaction with the intervention. Between-group effect sizes suggested that the CCST intervention led to improvements in relationship satisfaction for patients and partners and to improvements in intimacy and communication for patients. A couples-based communication intervention delivered via videoconference is feasible and acceptable in the context of advanced cancer. Preliminary findings suggest that the intervention shows promise in contributing to enhanced relationship functioning. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  13. Gamma-induced Positron Spectroscopy (GiPS) at a superconducting electron linear accelerator

    International Nuclear Information System (INIS)

    Butterling, Maik; Anwand, Wolfgang; Cowan, Thomas E.; Hartmann, Andreas; Jungmann, Marco; Krause-Rehberg, Reinhard; Krille, Arnold; Wagner, Andreas

    2011-01-01

    A new and unique setup for Positron Annihilation Spectroscopy has been established and optimized at the superconducting linear electron accelerator ELBE at Helmholtz-Zentrum Dresden-Rossendorf (Germany). The intense, pulsed (26 MHz) photon source (bremsstrahlung with energies up to 16 MeV) is used to generate positrons by means of pair production throughout the entire sample volume. Due to the very short gamma bunches (< 5 ps temporal length), the facility for Gamma-induced Positron Spectroscopy (GiPS) is suitable for positron lifetime spectroscopy using the accelerator's radiofrequency as time reference. Positron lifetime and Doppler broadening Spectroscopy are employed by a coincident measurement (Age-Momentum Correlation) of the time-of-arrival and energy of the annihilation photons which in turn significantly reduces the background of scattered photons resulting in spectra with high signal to background ratios. Simulations of the setup using the GEANT4 framework have been performed to yield optimum positron generation rates for various sample materials and improved background conditions.

  14. In-111-oxine red cells for imaging of intermittent G.I. bleeding sites

    International Nuclear Information System (INIS)

    Marcus, C.S.; Angulo, M.C.; Salk, R.D.; Essex, C.E.

    1985-01-01

    Sequential daily abdominal imaging was performed for up to 7 days in 11 patients with intermittent G.I. bleeding after the intravenous administration of lmCi autologous In-111-oxine labeled RBC's. The bleeding sites were identified in 3 patients. The causes were colon carcinoma, diverticulitis, and eroding distal aortic aneutysm. In addition to the imaging information, the authors have obtained preliminary biodistribution and kinetic data on the In-RBC's. Distribution to liver, spleen, and bone marrow was approximately 40%, 40%, and 20%, respectively. (This does not include the quantity of In-111 in the blood pool, which is very high initially and declines with time.) The survival of circulating In-RBC's is described by the equation: Surviving fraction=0.26e/sup -0.0021t/+0.74e/sup -0.00083t/ The halflives of the fast and slow components (x-bar+-x-bar) are 33.4 +- 1.6 hours and 35.0 +- 1.25 days, respectively. The In-oxine label is less stable than Cr-51 but more stable than Tc-99m. At 24 hours, Cr-RBC/In-RBC survival is 1.11 and Cr-RBC/Tc-RBC survival is 1.23. This imaging procedure is quite useful in selected patients

  15. Investigation of Microencapsulated BSH Active Lactobacillus in the Simulated Human GI Tract

    Directory of Open Access Journals (Sweden)

    Christopher Martoni

    2007-01-01

    Full Text Available This study investigated the use of microencapsulated bile salt hydrolase (BSH overproducing Lactobacillus plantarum 80 cells for oral delivery applications using a dynamic computer-controlled model simulating the human gastrointestinal (GI tract. Bile salt deconjugation rates for microencapsulated BSH overproducing cells were 4.87 ± 0.28 μmol/g microcapsule/h towards glycoconjugates and 0.79 ± 0.15 μmol/g microcapsule/h towards tauroconjugates in the simulated intestine, a significant (P< .05 increase over microencapsulated wild-type cells. Microcapsules protected the encased cells in the simulated stomach prior to intestinal release, maintaining cell viability above 109 cfu/mL at pH 2.5 and 3.0 and above 106 cfu/mL at pH 2.0 after 2-hour residence times. In the simulated intestine, encased cell viability was maintained above 1010 cfu/mL after 3, 6, and 12-hour residence times in bile concentrations up to 1.0%. Results show that microencapsulation has potential in the oral delivery of live BSH active bacterial cells. However, in vivo testing is required.

  16. Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs.

    Science.gov (United States)

    Navarro, Gemma; Cordomí, Arnau; Zelman-Femiak, Monika; Brugarolas, Marc; Moreno, Estefania; Aguinaga, David; Perez-Benito, Laura; Cortés, Antoni; Casadó, Vicent; Mallol, Josefa; Canela, Enric I; Lluís, Carme; Pardo, Leonardo; García-Sáez, Ana J; McCormick, Peter J; Franco, Rafael

    2016-04-05

    G-protein-coupled receptors (GPCRs), in the form of monomers or homodimers that bind heterotrimeric G proteins, are fundamental in the transfer of extracellular stimuli to intracellular signaling pathways. Different GPCRs may also interact to form heteromers that are novel signaling units. Despite the exponential growth in the number of solved GPCR crystal structures, the structural properties of heteromers remain unknown. We used single-particle tracking experiments in cells expressing functional adenosine A1-A2A receptors fused to fluorescent proteins to show the loss of Brownian movement of the A1 receptor in the presence of the A2A receptor, and a preponderance of cell surface 2:2 receptor heteromers (dimer of dimers). Using computer modeling, aided by bioluminescence resonance energy transfer assays to monitor receptor homomerization and heteromerization and G-protein coupling, we predict the interacting interfaces and propose a quaternary structure of the GPCR tetramer in complex with two G proteins. The combination of results points to a molecular architecture formed by a rhombus-shaped heterotetramer, which is bound to two different interacting heterotrimeric G proteins (Gi and Gs). These novel results constitute an important advance in understanding the molecular intricacies involved in GPCR function.

  17. Calibration of Discrete Random Walk (DRW) Model via G.I Taylor's Dispersion Theory

    Science.gov (United States)

    Javaherchi, Teymour; Aliseda, Alberto

    2012-11-01

    Prediction of particle dispersion in turbulent flows is still an important challenge with many applications to environmental, as well as industrial, fluid mechanics. Several models of dispersion have been developed to predict particle trajectories and their relative velocities, in combination with a RANS-based simulation of the background flow. The interaction of the particles with the velocity fluctuations at different turbulent scales represents a significant difficulty in generalizing the models to the wide range of flows where they are used. We focus our attention on the Discrete Random Walk (DRW) model applied to flow in a channel, particularly to the selection of eddies lifetimes as realizations of a Poisson distribution with a mean value proportional to κ / ɛ . We present a general method to determine the constant of this proportionality by matching the DRW model dispersion predictions for fluid element and particle dispersion to G.I Taylor's classical dispersion theory. This model parameter is critical to the magnitude of predicted dispersion. A case study of its influence on sedimentation of suspended particles in a tidal channel with an array of Marine Hydrokinetic (MHK) turbines highlights the dependency of results on this time scale parameter. Support from US DOE through the Northwest National Marine Renewable Energy Center, a UW-OSU partnership.

  18. Patient radiation doses in upper GI examinations: a comparison between conventional and double-contrast techniques.

    Science.gov (United States)

    Bankvall, G; Owman, T

    1982-01-01

    A total of 60 patients, divided into 3 groups with 20 patients in each, were examined with 3 different techniques: group 1 -- conventional technique, exposure at 120 kV; group 2 -- double-contrast technique (hypotonic gastrography, HG), exposure at 80 kW; group 3 -- HG, exposure at 120 kV. All examinations were performed in the same examination room and by the same radiologist. Absorbed doses to skin, thyroid, breasts, and gonads as well as energy imparted were measured. The only significant dose enhancements found when using double-contrast instead of conventional technique were in the female breasts and then only if the voltage was in the lower range. With exposure at 120 kV there was little difference in absorbed dose, but a significant advantage with respect to energy was imparted when using a double-contrast technique instead of a conventional technique. The testes doses were very low in all 3 types of examinations, and it seems that use of a testes shield is hardly motivated. With regard to both diagnostic accuracy and patient radiation dose, there can be no reason to use a conventional technique for upper GI examinations.

  19. Gamma-induced Positron Spectroscopy (GiPS) at a superconducting electron linear accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Butterling, Maik, E-mail: maik.butterling@googlemail.com [Martin-Luther University, Dept. of Physics, 06099 Halle (Germany); Institute of Radiation Physics, Helmholtz-Zentrum, Dresden-Rossendorf, P.O. Box 510119, 01314 Dresden (Germany); Anwand, Wolfgang; Cowan, Thomas E.; Hartmann, Andreas [Institute of Radiation Physics, Helmholtz-Zentrum, Dresden-Rossendorf, P.O. Box 510119, 01314 Dresden (Germany); Jungmann, Marco; Krause-Rehberg, Reinhard [Martin-Luther University, Dept. of Physics, 06099 Halle (Germany); Krille, Arnold; Wagner, Andreas [Institute of Radiation Physics, Helmholtz-Zentrum, Dresden-Rossendorf, P.O. Box 510119, 01314 Dresden (Germany)

    2011-11-15

    A new and unique setup for Positron Annihilation Spectroscopy has been established and optimized at the superconducting linear electron accelerator ELBE at Helmholtz-Zentrum Dresden-Rossendorf (Germany). The intense, pulsed (26 MHz) photon source (bremsstrahlung with energies up to 16 MeV) is used to generate positrons by means of pair production throughout the entire sample volume. Due to the very short gamma bunches (< 5 ps temporal length), the facility for Gamma-induced Positron Spectroscopy (GiPS) is suitable for positron lifetime spectroscopy using the accelerator's radiofrequency as time reference. Positron lifetime and Doppler broadening Spectroscopy are employed by a coincident measurement (Age-Momentum Correlation) of the time-of-arrival and energy of the annihilation photons which in turn significantly reduces the background of scattered photons resulting in spectra with high signal to background ratios. Simulations of the setup using the GEANT4 framework have been performed to yield optimum positron generation rates for various sample materials and improved background conditions.

  20. Reconfiguración del sicario en Felicidad quizás de Mario Salazar Montero y Los restos del vellocino de oro de Alfredo Vanín

    Directory of Open Access Journals (Sweden)

    Margarita Jácome

    2012-06-01

    Full Text Available Este artículo analiza la transformación de la figura del sicario como personaje de ficción en la novela colombiana reciente sobre la base de su representación en los textos Felicidad quizás de Mario Salazar Montero y Los restos del vellocino de oro de Alfredo Vanín. Además de estudiar dicha representación en cada novela en particular, se la compara y contrasta con el perfil del asesino a sueldo establecido por la novela sicaresca de los años noventa, para proponer algunas características de la evolución del género evidenciadas en textos enmarcados en diversos tipos de violencia.This article analyzes the transformation of the hit-man - sicario - as a fictional character in recent Colombian narratives, based upon its representation in Felicidad quizás by Mario Salazar Montero and Los restos del vellocino de oro by Alfredo Vanín. Besides studying the sicario figure in each novel, this article compares and contrasts the recent image of the hired assassin to the one established by the sicaresca novel of the 90´s. Additionally, this methodology helps pointing out some characteristics in the evolution of this literary genre within the context of diverse types of violence.

  1. EFFECTIVENESS OF QUIZ TEAM AND MURDER METHOD ON LEARNING ACTIVITIES AND PROBLEM SOLVING SKILLS IN SOCIAL SCIENCE LEARNING FOR 8th GRADE STUDENTS AT UPI LABORATORY JUNIOR HIGH SCHOOL

    Directory of Open Access Journals (Sweden)

    Darwanti Darwanti

    2017-06-01

    Full Text Available There are three objectives that shape the study, first, the study is aimed at identifying different problem-solving skills of the students' who were acquainted with quiz team, lecture and MURDER method. Secondly, the study is to point out the difference of students' problem-solving skills when they are exposed to the three methods in a high, moderate, and low intensity. The third objective is to determine interactions among learning methods, learning activities and problem-solving skills. Quasi experiment is used as a method of the study by applying two experiment classes, and one controlled factorial designed class. In analyzing the data, a two-way Anova analysis and variants analysis are implemented to measure the interaction level among the three variables. The results of the study indicate that (1 there are differences in students' problem-solving skills who were exposed to quiz team, lecture and MURDER method; (2 there are also differences in students' problem-solving skills when they were exposed by the mentioned methods in a high, moderate, and low intensity; there are no relevant interactions among learning methods, learning activities and problem-solving skills. The current results are presented such that they can be used as an aid to the methods of social science learning.

  2. The influence of monovalent cations on trimeric G protein Gi1alfa activity in HEK293 cells stably expressing DOR-Gi1alfa (Cys351-Ile351) fusion protein

    Czech Academy of Sciences Publication Activity Database

    Vošahlíková, Miroslava; Svoboda, Petr

    2011-01-01

    Roč. 60, č. 3 (2011), s. 541-547 ISSN 0862-8408 R&D Projects: GA AV ČR(CZ) IAA500110606; GA MŠk(CZ) LC554; GA ČR(CZ) GD305/08/H037 Institutional research plan: CEZ:AV0Z50110509 Keywords : delta-opioid receptor (DOR) * monovalent ions * G(i)1alfa protein Subject RIV: CE - Biochemistry Impact factor: 1.555, year: 2011

  3. On the calculation of steady-state loss probabilities in the GI/G/2/0 queue

    Directory of Open Access Journals (Sweden)

    Igor N. Kovalenko

    1994-01-01

    Full Text Available This paper considers methods for calculating the steady-state loss probability in the GI/G/2/0 queue. A previous study analyzed this queue in discrete time and this led to an efficient, numerical approximation scheme for continuous-time systems. The primary aim of the present work is to provide an alternative approach by analyzing the GI/ME/2/0 queue; i.e., assuming that the service time can be represented by a matrix-exponential distribution. An efficient computational scheme based on this method is developed and some numerical examples are studied. Some comparisons are made with the discrete-time approach, and the two methods are seen to be complementary.

  4. Using Internet Snapshot Surveys to Enhance Our Understanding of the Availability of the Novel Psychoactive Substance Alpha-methyltryptamine (AMT).

    Science.gov (United States)

    Wood, David Michael; Dargan, Paul Ivor

    2013-07-02

    Alpha-methyltryptamine (AMT) is a novel psychoactive substance available over the Internet. This study used European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) Internet snapshot methodology to investigate the availability and cost of AMT in March/October 2012. From March to October 2012, there was a decrease in the number of Internet sites selling AMT (44 to 31). AMT powder was cheaper in "bulk" (100 g) than in "recreational-user" (100 mg) quantities, and there was a decrease in price. Data from Internet snapshot surveys complement and allow triangulation of data from other sources to build a more detailed picture on availability and use of novel psychoactive substances.

  5. Effectiveness of current disinfection procedures against biofilm on contaminated GI endoscopes.

    Science.gov (United States)

    Neves, Marcelo S; da Silva, Marlei Gomes; Ventura, Grasiella M; Côrtes, Patrícia Barbur; Duarte, Rafael Silva; de Souza, Heitor S

    2016-05-01

    Attention to patient safety has increased recently due to outbreaks of nosocomial infections associated with GI endoscopy. The aim of this study was to evaluate current cleaning and disinfection procedures of endoscope channels with high bioburden and biofilm analysis, including the use of resistant mycobacteria associated with postsurgical infections in Brazil. Twenty-seven original endoscope channels were contaminated with organic soil containing 10(8) colony-forming units/mL of Pseudomonas aeruginosa, Staphylococcus aureus, or Mycobacterium abscessus subsp bolletii. Biofilms with the same microorganisms were developed on the inner surface of channels with the initial inoculum of 10(5) colony-forming units/mL. Channels were reprocessed following current protocol, and samples from cleaning and disinfection steps were analyzed by bioluminescence for adenosine triphosphate, cultures for viable microorganisms, and confocal microscopy. After contamination, adenosine triphosphate levels increased dramatically, and high bacterial growth was observed in all cultures. After cleaning, adenosine triphosphate levels decreased to values comparable to precontamination levels, and bacterial growth was demonstrated in 5 of 27 catheters, 2 with P aeruginosa and 3 with M abscessus. With regard to induced biofilm, a remarkable reduction occurred after cleaning, but significant microbial growth inhibition occurred only after disinfection. Nevertheless, viable microorganisms within the biofilm were still detected by confocal microscopy, more so with glutaraldehyde than with peracetic acid or O-phataladehyde. After the complete disinfection procedure, viable microorganisms could still be detected within the biofilm on endoscope channels. Prevention of biofilm development within endoscope channels should be a priority in disinfection procedures, particularly for ERCP and EUS. Copyright © 2016 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights

  6. SU-E-T-41: Analysis of GI Dose Variability Due to Intrafraction Setup Variance

    International Nuclear Information System (INIS)

    Phillips, J; Wolfgang, J

    2014-01-01

    insensitive to motion for patients undergoing proton SBRT in the GI tract

  7. Konkurentsi kahjustav seosmüük. Konkurentsiameti seisukohtade kooskõla konkurentsi kahjustava seosmüügi tuvastamisel Euroopa Liidu õiguspraktikaga : [bakalaureusetöö] / Victoria Saue ; Tartu Ülikool, õigusteaduskond ; juhendaja: Risto Rüü

    Index Scriptorium Estoniae

    Saue, Victoria

    2010-01-01

    Seosmüügi kui turgu valitseva seisundi kuritarvitamise viisist, konkurentsi kahjustavast seosmüügi tuvastamisest EL ja Eesti õiguspraktikas, Konkurentsiameti seisukohtade kooskõlast EL õiguspraktikaga

  8. The SNAPSHOT study protocol: SNAcking, Physical activity, Self-regulation, and Heart rate Over Time.

    Science.gov (United States)

    McMinn, David; Allan, Julia L

    2014-09-26

    The cognitive processes responsible for effortful behavioural regulation are known as the executive functions, and are implicated in several factors associated with behaviour control, including focussing on tasks, resisting temptations, planning future actions, and inhibiting prepotent responses. Similar to muscles, the executive functions become fatigued following intensive use (e.g. stressful situations, when tired or busy, and when regulating behaviour such as quitting smoking). Therefore, an individual may be more susceptible to engaging in unhealthy behaviours when their executive functions are depleted. In the present study we investigate associations between the executive functions, snack food consumption, and sedentary behaviour in real time. We hypothesise that individuals may be more susceptible to unhealthy snacking and sedentary behaviours during periods when their executive functions are depleted. We test this hypothesis using real-time objective within-person measurements. A sample of approximately 50 Scottish adults from varied socio-economic, working, and cultural backgrounds will participate in the three phases of the SNAcking, Physical activity, Self-regulation, and Heart rate Over Time (SNAPSHOT) study. Phase one will require participants to complete home-based questionnaires concerned with diet, eating behaviour, and physical activity (≈1.5 hours to complete). Phase two will constitute a 2-3 hour psychological laboratory testing session during which trait-level executive function, general intelligence, and diet and physical activity intentions, past behaviour, and automaticity will be measured. The final phase will involve a 7-day ambulatory protocol during which objective repeated assessments of executive function, snacking behaviour, physical activity, mood, heart rate, perceived energy level, current context and location will be measured during participants' daily routines. Multi-level regression analysis, accounting for observations nested

  9. The Market of Biopharmaceutical Medicines: A Snapshot of a Diverse Industrial Landscape

    Directory of Open Access Journals (Sweden)

    Evelien Moorkens

    2017-06-01

    Full Text Available Background: Biopharmaceutical medicines represent a growing share of the global pharmaceutical market, and with many of these biopharmaceutical products facing loss of exclusivity rights, also biosimilars may now enter the biopharmaceutical market.Objectives: This study aims to identify and document which investment and development strategies are adopted by industrial players in the global biopharmaceutical market.Methods: A descriptive analysis was undertaken of the investment and development strategies of the top 25 pharmaceutical companies according to 2015 worldwide prescription drug sales. Strategies were documented by collecting data on manufacturing plans, development programs, acquisition and collaboration agreements, the portfolio and pipeline of biosimilar, originator and next-generation biopharmaceutical products. Data were extracted from publicly available sources.Results: Various investment and development strategies can be identified in the global biopharmaceutical market: (a development of originator biopharmaceuticals, (b investment in biotechnology, (c development of next-generation biopharmaceuticals, (d development of biosimilars, (e investment in emerging countries, and (f collaboration between companies. In the top 25 pharmaceutical companies almost every company invests in originator biopharmaceuticals and in biotechnology in general, but only half of them develops next-generation biopharmaceuticals. Furthermore, only half of them invest in development of biosimilars. The companies' biosimilar pipeline is mainly focused on development of biosimilar monoclonal antibodies and to some extent on biosimilar insulins. A common strategy is collaboration between companies and investment in emerging countries.Conclusions: A snapshot of investment and development strategies used by industrial players in the global biopharmaceutical market shows that all top 25 pharmaceutical companies are engaged in the biopharmaceutical market and

  10. Technology for detecting spectral radiance by a snapshot multi-imaging spectroradiometer

    Science.gov (United States)

    Zuber, Ralf; Stührmann, Ansgar; Gugg-Helminger, Anton; Seckmeyer, Gunther

    2017-12-01

    Technologies to determine spectral sky radiance distributions have evolved in recent years and have enabled new applications in remote sensing, for sky radiance measurements, in biological/diagnostic applications and luminance measurements. Most classical spectral imaging radiance technologies are based on mechanical and/or spectral scans. However, these methods require scanning time in which the spectral radiance distribution might change. To overcome this limitation, different so-called snapshot spectral imaging technologies have been developed that enable spectral and spatial non-scanning measurements. We present a new setup based on a facet mirror that is already used in imaging slicing spectrometers. By duplicating the input image instead of slicing it and using a specially designed entrance slit, we are able to select nearly 200 (14 × 14) channels within the field of view (FOV) for detecting spectral radiance in different directions. In addition, a megapixel image of the FOV is captured by an additional RGB camera. This image can be mapped onto the snapshot spectral image. In this paper, the mechanical setup, technical design considerations and first measurement results of a prototype are presented. For a proof of concept, the device is radiometrically calibrated and a 10 mm × 10 mm test pattern measured within a spectral range of 380 nm-800 nm with an optical bandwidth of 10 nm (full width at half maximum or FWHM). To show its potential in the UV spectral region, zenith sky radiance measurements in the UV of a clear sky were performed. Hence, the prototype was equipped with an entrance optic with a FOV of 0.5° and modified to obtain a radiometrically calibrated spectral range of 280 nm-470 nm with a FWHM of 3 nm. The measurement results have been compared to modeled data processed by UVSPEC, which showed deviations of less than 30%. This is far from being ideal, but an acceptable result with respect to available state

  11. Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates bronchial contractility and relaxation

    OpenAIRE

    McGraw, Dennis W.; Elwing, Jean M.; Fogel, Kevin M.; Wang, Wayne C.H.; Glinka, Clare B.; Mihlbachler, Kathryn A.; Rothenberg, Marc E.; Liggett, Stephen B.

    2007-01-01

    Receptor-mediated airway smooth muscle (ASM) contraction via Gαq, and relaxation via Gαs, underlie the bronchospastic features of asthma and its treatment. Asthma models show increased ASM Gαi expression, considered the basis for the proasthmatic phenotypes of enhanced bronchial hyperreactivity to contraction mediated by M3-muscarinic receptors and diminished relaxation mediated by β2-adrenergic receptors (β2ARs). A causal effect between Gi expression and phenotype has not been established, n...

  12. Reduction of Human Norovirus GI, GII, and Surrogates by Peracetic Acid and Monochloramine in Municipal Secondary Wastewater Effluent.

    Science.gov (United States)

    Dunkin, Nathan; Weng, ShihChi; Coulter, Caroline G; Jacangelo, Joseph G; Schwab, Kellogg J

    2017-10-17

    The objective of this study was to characterize human norovirus (hNoV) GI and GII reductions during disinfection by peracetic acid (PAA) and monochloramine in secondary wastewater (WW) and phosphate buffer (PB) as assessed by reverse transcription-qPCR (RT-qPCR). Infectivity and RT-qPCR reductions are also presented for surrogate viruses murine norovirus (MNV) and bacteriophage MS2 under identical experimental conditions to aid in interpretation of hNoV molecular data. In WW, RT-qPCR reductions were less than 0.5 log 10 for all viruses at concentration-time (CT) values up to 450 mg-min/L except for hNoV GI, where 1 log 10 reduction was observed at CT values of less than 50 mg-min/L for monochloramine and 200 mg-min/L for PAA. In PB, hNoV GI and MNV exhibited comparable resistance to PAA and monochloramine with CT values for 2 log 10 RT-qPCR reduction between 300 and 360 mg-min/L. Less than 1 log 10 reduction was observed for MS2 and hNoV GII in PB at CT values for both disinfectants up to 450 mg-min/L. Our results indicate that hNoVs exhibit genogroup dependent resistance and that disinfection practices targeting hNoV GII will result in equivalent or greater reductions for hNoV GI. These data provide valuable comparisons between hNoV and surrogate molecular signals that can begin the process of informing regulators and engineers on WW treatment plant design and operational practices necessary to inactivate hNoVs.

  13. EuGI: a novel resource for studying genomic islands to facilitate horizontal gene transfer detection in eukaryotes.

    Science.gov (United States)

    Clasen, Frederick Johannes; Pierneef, Rian Ewald; Slippers, Bernard; Reva, Oleg

    2018-05-03

    Genomic islands (GIs) are inserts of foreign DNA that have potentially arisen through horizontal gene transfer (HGT). There are evidences that GIs can contribute significantly to the evolution of prokaryotes. The acquisition of GIs through HGT in eukaryotes has, however, been largely unexplored. In this study, the previously developed GI prediction tool, SeqWord Gene Island Sniffer (SWGIS), is modified to predict GIs in eukaryotic chromosomes. Artificial simulations are used to estimate ratios of predicting false positive and false negative GIs by inserting GIs into different test chromosomes and performing the SWGIS v2.0 algorithm. Using SWGIS v2.0, GIs are then identified in 36 fungal, 22 protozoan and 8 invertebrate genomes. SWGIS v2.0 predicts GIs in large eukaryotic chromosomes based on the atypical nucleotide composition of these regions. Averages for predicting false negative and false positive GIs were 20.1% and 11.01% respectively. A total of 10,550 GIs were identified in 66 eukaryotic species with 5299 of these GIs coding for at least one functional protein. The EuGI web-resource, freely accessible at http://eugi.bi.up.ac.za , was developed that allows browsing the database created from identified GIs and genes within GIs through an interactive and visual interface. SWGIS v2.0 along with the EuGI database, which houses GIs identified in 66 different eukaryotic species, and the EuGI web-resource, provide the first comprehensive resource for studying HGT in eukaryotes.

  14. Effect of Pseudomonas contamination or antibiotic decontamination of the GI tract on acute radiation lethality after neutron or gamma irradiation

    International Nuclear Information System (INIS)

    Geraci, J.P.; Jackson, K.L.; Mariano, M.S.

    1985-01-01

    The influence of antibiotic decontamination of Pseudomonas contamination of the GI tract prior to whole-body neutron or gamma irradiation was studied. It was observed that for fission neutron doses greater than 5.5 Gy, cyclotron-produced neutron doses greater than 6.7 Gy, and 137Cs gamma-ray doses greater than 14.4 Gy, the median survival time of untreated rats was relatively constant at 4.2 to 4.5 days, indicating death was due to intestinal injury. Within the dose range of 3.5 to 5.5 Gy of fission neutrons, 4.9 to 6.7 Gy of cyclotron-produced neutrons, and 9.6 to 14.4 Gy of gamma rays, median survival time of these animals was inversely related to dose and varied from 12 to 4.6 days. This change in survival time with dose reflects a transition in the mechanisms of acute radiation death from pure hematopoietic, to a combination of intestinal and hematopoietic, to pure intestinal death. Decontamination of the GI tract with antibiotics prior to irradiation increased median survival time 1 to 5 days in this transitional dose range. Contamination of the intestinal flora with Pseudomonas aeruginosa prior to irradiation reduced median survival time 1 to 5 days in the same radiation dose range. Pseudomonas-contaminated animals irradiated within this transitional dose range had maximum concentrations of total bacteria and Pseudomonas in their livers at the time of death. However, liver bacteria concentration was usually higher in gamma-irradiated animals, due to a smaller contribution of hematopoietic injury in neutron-irradiated animals. The effects of both decontamination of the GI tract and Pseudomonas contamination of the GI tract were negligible in the range of doses in which median survival time was dose independent, i.e., in the pure intestinal death dose range

  15. Long-term functional outcomes of PPPD in children--Nutritional status, pancreatic function, GI function and QOL.

    Science.gov (United States)

    Park, Hwon-Ham; Kim, Hyun-Young; Jung, Sung-Eun; Lee, Seong-Cheol; Park, Kwi-Won

    2016-03-01

    The purpose of this study was to analyze the long-term outcomes, such as nutritional status, pancreatic function, gastrointestinal (GI) function, and quality of life (QOL), in children who underwent pylorus-preserving pancreaticoduodenectomy (PPPD). Between 1992 and 2013, there were 15 children who underwent PPPD at Seoul National University Children's Hospital, and 10 of them participated in this study. A retrospective review of the patients' medical records and follow-up was done. Their nutritional statuses were estimated by height, body weight, weight for age Z-score, body mass index (BMI), and serum protein, albumin levels. The endocrine and exocrine functions of the pancreas were estimated by diabetes mellitus (DM), steatorrhea, and Bristol stool chart. The GI function and QOL were evaluated via questionnaires. The follow-up period ranged from 3 to 18years. There were no severe growth disturbances, 6 patients experienced mild steatorrhea and 3 showed above the category 6 in Bristol stool chart. All the patients experienced mild GI symptoms. As for the QOL, there were no significant negative answers, except for one patient with DM. Almost all the study subjects, who underwent PPPD in their childhood, did not present significant problems except for one patient with DM. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. Snapshots of high-latitude electrodynamics using Viking and DMSP F7 observations

    International Nuclear Information System (INIS)

    Marklund, G.T.; Blomberg, L.G.; Stasiewicz, K.; Murphree, J.S.; Pottelette, R.; Zanetti, L.J.; Potemra, T.A.; Hardy, D.A.; Rich, F.J.

    1988-01-01

    Simultandeous observations by the Viking an the DMSP F7 satellites have been used as input to a new method to obtain snapshot pictures of the auroral electrodynamics. In particular, an ''instantaneous'' global equipotential (or convection) pattern is calculated from distributions of field-aligned current and conductivity which are qualitatively consistent with the Viking auroral imager data and quantitatively consistent with magnetic field and particle data from the two satellites. This convection pattern, which is of the normal two-cell type, with a weak dusk cell and a strong, elongated crescent-shape dawn cell (consistent with positive interplanetary magnetic field B/sub y/), agrees well with the Viking electric field data. The model and the observed potential profiles agree nicely along the entire Viking orbit except for two intervals above acceleration regions where deviations are to be expected (due to parallel electric fields). These regions are characterized by U-shaped potential minima, upward field-aligned currents, upgoing ion beams, and relatively intense auroral kilometric radiation. Thus, the model results are consistent with the Viking observations not only on a global scale but also on the scale of the auroral acceleration regions. The corresponding convection in the magnetosphere is obtained from a simple projection to the equatorial plane of the deduced two-cell convection pattern. From this location of the plasmapause is inferred. copyright American Geophysical Union 1988

  17. Snapshot of the Eukaryotic Gene Expression in Muskoxen Rumen—A Metatranscriptomic Approach

    Science.gov (United States)

    O'Toole, Nicholas; Barboza, Perry S.; Ungerfeld, Emilio; Leigh, Mary Beth; Selinger, L. Brent; Butler, Greg; Tsang, Adrian; McAllister, Tim A.; Forster, Robert J.

    2011-01-01

    Background Herbivores rely on digestive tract lignocellulolytic microorganisms, including bacteria, fungi and protozoa, to derive energy and carbon from plant cell wall polysaccharides. Culture independent metagenomic studies have been used to reveal the genetic content of the bacterial species within gut microbiomes. However, the nature of the genes encoded by eukaryotic protozoa and fungi within these environments has not been explored using metagenomic or metatranscriptomic approaches. Methodology/Principal Findings In this study, a metatranscriptomic approach was used to investigate the functional diversity of the eukaryotic microorganisms within the rumen of muskoxen (Ovibos moschatus), with a focus on plant cell wall degrading enzymes. Polyadenylated RNA (mRNA) was sequenced on the Illumina Genome Analyzer II system and 2.8 gigabases of sequences were obtained and 59129 contigs assembled. Plant cell wall degrading enzyme modules including glycoside hydrolases, carbohydrate esterases and polysaccharide lyases were identified from over 2500 contigs. These included a number of glycoside hydrolase family 6 (GH6), GH48 and swollenin modules, which have rarely been described in previous gut metagenomic studies. Conclusions/Significance The muskoxen rumen metatranscriptome demonstrates a much higher percentage of cellulase enzyme discovery and an 8.7x higher rate of total carbohydrate active enzyme discovery per gigabase of sequence than previous rumen metagenomes. This study provides a snapshot of eukaryotic gene expression in the muskoxen rumen, and identifies a number of candidate genes coding for potentially valuable lignocellulolytic enzymes. PMID:21655220

  18. Snapshot Views of the Romanian Economy on Regional Level Using Input-Output Methodology

    Directory of Open Access Journals (Sweden)

    BORÓKA-JÚLIA BÍRÓ

    2014-06-01

    Full Text Available Our present paper proposes to give snapshot views on the status-quo of the Romanian economy at the level of development regions. From a methodological perspective, the study is based on the construction of an aggregated national Input-Output table from the more detailed one of the National Institute of Statistics, followed by the derivation of regional tables using the non-survey GRIT technique. Quantitative sectoral interrelationships are going to be analysed based on multipliers, backward and forward linkages in order to identify key sectors within regional economies. This could serve as a baseline for assessing the impact of several policies of the European Union on the Romanian economy, such as the Cohesion Policy and the Common Agricultural Policy. The lower territorial approach – i.e. the construction of regional Input-Output models – used within the present study is in accordance with the European Union’s NUTS2 level policy design and planning philosophy on the one hand. On the other hand, this analytic direction makes possible the use of the results as a base for regional economic development strategy design, highlighting structural specificities and discrepancies among regions of the same country.

  19. Stable panoramic views facilitate snap-shot like memories for spatial reorientation in homing pigeons.

    Directory of Open Access Journals (Sweden)

    Tommaso Pecchia

    Full Text Available Following spatial disorientation, animals can reorient themselves by relying on geometric cues (metric and sense specified both by the macroscopic surface layout of an enclosed space and prominent visual landmarks in arrays. Whether spatial reorientation in arrays of landmarks is based on explicit representation of the geometric cues is a matter of debate. Here we trained homing pigeons (Columba livia to locate a food-reward in a rectangular array of four identical or differently coloured pipes provided with four openings, only one of which allowed the birds to have access to the reward. Pigeons were trained either with a stable or a variable position of the opening on pipes, so that they could view the array either from the same or a variable perspective. Explicit mapping of configural geometry would predict successful reorientation irrespective of access condition. In contrast, we found that a stable view of the array facilitated spatial learning in homing pigeons, likely through the formation of snapshot-like memories.

  20. Snapshot Survey of the Globular Cluster Populations of Isolated Early Type Galaxies

    Science.gov (United States)

    Gregg, Michael

    2017-08-01

    We propose WFC3/UVIS snapshot observations of a sample of 75 isolated early type galaxiesresiding in cosmic voids or extremely low density regions. The primary aim is to usetheir globular cluster populations to reconstruct their evolutionary history, revealingif, how, and why void ellipticals differ from cluster ellipticals. The galaxies span arange of luminosities, providing a varied sample for comparison with the well-documentedglobular cluster populations in denser environments. This proposed WFC3 study of isolatedearly type galaxies breaks new ground by targeting a sample which has thus far receivedlittle attention, and, significantly, this will be the first such study with HST.Characterizing early type galaxies in voids and their GC systems promises to increase ourunderstanding of galaxy formation and evolution of galaxies in general because isolatedobjects are the best approximation to a control sample that we have for understanding theinfluence of environment on formation and evolution. Whether these isolated objects turnout to be identical to or distinct from counterparts in other regions of the Universe,they will supply insight into the formation and evolution of all galaxies. Parallel ACSimaging will help to characterize the near field environments of the sample.

  1. Snapshots of Dynamics in Synthesizing N6-isopentenyladenosine at tRNA Anticodon†,‡

    Science.gov (United States)

    Chimnaronk, Sarin; Forouhar, Farhad; Sakai, Junichi; Yao, Min; Tron, Cecile M.; Atta, Mohamed; Fontecave, Marc; Hunt, John F.; Tanaka, Isao

    2009-01-01

    Bacterial and eukaryotic transfer RNAs that decode codons starting with uridine have a hydrophobically-hypermodified adenosine at the position 37 (A37) adjacent to the 3′-end of the anticodon, which is essential for efficient and highly accurate protein translation by the ribosome. However, it remains unclear how the corresponding tRNAs are selected to be modified by alkylation at the correct position of the adenosine base. We have determined a series of the crystal structures of bacterial tRNA isopentenyltransferase (MiaA) in apo- and tRNA-bound forms, which completely render snapshots of substrate selections during modification of RNA. A compact evolutionary inserted domain (herein ‘swinging domain’) in MiaA that exhibits as a highly mobile entity moves around the catalytic domain as likely to reach and trap the tRNA substrate. Thereby, MiaA clamps the anticodon stem loop of tRNA substrate between the catalytic and swinging domains, where the two conserved elongated residues from the swinging domain pinch the two flanking A36 and A38 together to squeeze out A37 into the reaction tunnel. The site-specific isopentenylation of RNA is thus ensured by a characteristic pinch-and-flip mechanism and by a reaction tunnel to confine the substrate selection. Furthermore, combining information from soaking experiments with structural comparisons, we propose a mechanism for the ordered substrate-binding of MiaA. PMID:19435325

  2. Snapshots of high-latitude electrodynamics using Viking and DMSP/F7 observations

    International Nuclear Information System (INIS)

    Marklund, G.T.; Blomberg, L.G.; Murphree, J.S.; Pottelette, R.; Zanetti, L.J.; Potemra, T.A.; Hardy, D.A.; Rich, F.J.

    1988-02-01

    Simultaneous observations by the Viking and the DMSP/F7 satellites have been used in a new method to obtain snapshot pictures of the auroral electrodynamics. In particular, an 'instantaneous' global equipotential (or convection) pattern is calculated using field-aligned current and conductivity distributions that are qualitatively consistent with the Viking auroral imager data and quantitatively consistent with magnetic field and particle data from the two satellites. This convection pattern which is of the normal two-cell type, with a weak dusk cell and a strong, elongated crescent-shaped dawn cell (consistent with positive IMF B y ) agrees well with the Viking electric field data. The model and the observed potential profiles agree nicely along the entire Viking orbit except for two intervals above acceleration regions where deviations are to be expected (due to parallel electric fields). These regions are characterized by: U-shaped potential minima, upward field-aligned currents, upgoing ion beams and relatively intense AKR. The model results are thus consistent with the Viking observations not only on a global scale but also on the scale size of the auroral acceleration regions. The corresponding convection in the magnetosphere is illustrated by a simple projection of the deduced two-cell convection pattern to the equatorial plane. From this the instantaneous location of the plasmapause is inferred. (authors)

  3. INFLUENCE OF THE VIEWING GEOMETRY WITHIN HYPERSPECTRAL IMAGES RETRIEVED FROM UAV SNAPSHOT CAMERAS

    Directory of Open Access Journals (Sweden)

    H. Aasen

    2016-06-01

    Full Text Available Hyperspectral data has great potential for vegetation parameter retrieval. However, due to angular effects resulting from different sun-surface-sensor geometries, objects might appear differently depending on the position of an object within the field of view of a sensor. Recently, lightweight snapshot cameras have been introduced, which capture hyperspectral information in two spatial and one spectral dimension and can be mounted on unmanned aerial vehicles. This study investigates the influence of the different viewing geometries within an image on the apparent hyperspectral reflection retrieved by these sensors. Additionally, it is evaluated how hyperspectral vegetation indices like the NDVI are effected by the angular effects within a single image and if the viewing geometry influences the apparent heterogeneity with an area of interest. The study is carried out for a barley canopy at booting stage. The results show significant influences of the position of the area of interest within the image. The red region of the spectrum is more influenced by the position than the near infrared. The ability of the NDVI to compensate these effects was limited to the capturing positions close to nadir. The apparent heterogeneity of the area of interest is the highest close to a nadir.

  4. Cereal Consumption among Subjects with Celiac Disease: A Snapshot for Nutritional Considerations

    Directory of Open Access Journals (Sweden)

    Francesco Valitutti

    2017-04-01

    Full Text Available Background: To our knowledge no study has focused on the pattern of cereal-based products (CBP consumption among people with celiac disease (CD. Our study aimed at evaluating the dietary intake of CBP among patients with CD and comparing it with a control population. Methods: Eighty-two volunteers with CD and 77 non-CD volunteers enrolled throughout Italy were asked to register their consumption of CBP on specific diaries for three days. Results: CD patients’ median three-day intake of biscuits and crackers was higher compared to controls (65.8 g vs. 22.7 g and 44.7 g vs. 10.6 g, p < 0.05 respectively, Mann–Whitney test. A significant difference was observed also comparing the two groups for median three-day bread consumption, with the CD group consuming less bread than controls (109.5 g vs. 150.7 g, p < 0.05, Mann–Whitney test. When assessing regional and gender-related CBP consumption patterns, significantly higher rice consumption was found among CD women from Northern Italy compared to CD women from Central and Southern Italy (p = 0.006 and p = 0.002 respectively, Fisher’s exact test. No other significant differences were observed. Conclusions: Our results provide a snapshot of the overall consumption of CBP among Italian subjects with CD. Altogether, these data show that, despite minor differences, dietary consumption of CBP among CD patients is similar to the general population.

  5. Femtosecond Snapshots of quantum mechanics at work in plasmonic nano-structures

    Science.gov (United States)

    Carbone, Fabrizio

    Ultrafast Transmission Electron Microscopy enabled a new technique (Photon-Induced Near Field Electron Microscopy, PINEM), capable of controlling electromagnetic fields confined on the surface of nanostructures and image their properties with nm-resolution in direct space and fs resolution in time. In this presentation, we will show some recent results where the standing wave formed by the plasmonic field confined on the surface of one silver nano-wire was imaged together with its energy exchange with the imaging electrons. In these results, both the interference and the quantization of the plasmonic near field could be imaged simultaneously, revealing both a quantum and a classical aspect of the electromagnetic field in one snapshot. The implications of these results will be discussed, and we will also present new ideas and methodologies to go beyond such an experiment and image the interaction between single electrons and single plasmons. We will also show that shaping the electron density in a thin film via light pulses is possible by taking advantage of the plasmon-plasmon interference and the ability of light polarization to control the excitation of different plasmonic field geometries in ad hoc designed nanostructures. Movies of the propagation of plasmons will also be presented, providing insights into their speed, propagation losses and the effect of confinment. This work was supported by an ERC Grant USED.

  6. Snapshot of the eukaryotic gene expression in muskoxen rumen--a metatranscriptomic approach.

    Directory of Open Access Journals (Sweden)

    Meng Qi

    Full Text Available BACKGROUND: Herbivores rely on digestive tract lignocellulolytic microorganisms, including bacteria, fungi and protozoa, to derive energy and carbon from plant cell wall polysaccharides. Culture independent metagenomic studies have been used to reveal the genetic content of the bacterial species within gut microbiomes. However, the nature of the genes encoded by eukaryotic protozoa and fungi within these environments has not been explored using metagenomic or metatranscriptomic approaches. METHODOLOGY/PRINCIPAL FINDINGS: In this study, a metatranscriptomic approach was used to investigate the functional diversity of the eukaryotic microorganisms within the rumen of muskoxen (Ovibos moschatus, with a focus on plant cell wall degrading enzymes. Polyadenylated RNA (mRNA was sequenced on the Illumina Genome Analyzer II system and 2.8 gigabases of sequences were obtained and 59129 contigs assembled. Plant cell wall degrading enzyme modules including glycoside hydrolases, carbohydrate esterases and polysaccharide lyases were identified from over 2500 contigs. These included a number of glycoside hydrolase family 6 (GH6, GH48 and swollenin modules, which have rarely been described in previous gut metagenomic studies. CONCLUSIONS/SIGNIFICANCE: The muskoxen rumen metatranscriptome demonstrates a much higher percentage of cellulase enzyme discovery and an 8.7x higher rate of total carbohydrate active enzyme discovery per gigabase of sequence than previous rumen metagenomes. This study provides a snapshot of eukaryotic gene expression in the muskoxen rumen, and identifies a number of candidate genes coding for potentially valuable lignocellulolytic enzymes.

  7. Tobacco point-of-sale displays in England: a snapshot survey of current practices.

    Science.gov (United States)

    Rooke, Catriona; Cheeseman, Hazel; Dockrell, Martin; Millward, Deborah; Sandford, Amanda

    2010-08-01

    Tobacco displays at the point of sale (PoS) are an important means for the tobacco industry to communicate with consumers. With regulations prohibiting PoS displays recently having come into force in Ireland, passed into law in England, Wales and Northern Ireland and some Australian states, and being considered in New Zealand, Finland and Brazil, this is an increasingly important issue. This study explores the nature of displays, the extent to which they are tobacco industry funded, and the relation between the tobacco companies and retailers. Three areas were chosen to gain a snapshot of PoS displays in England. Over 100 retailers were visited, with interviews taking place on site. Information was gathered on the type and size of tobacco display, who was paying for the display, requirements and incentives, and visits by industry representatives. The majority of retailers had gantries provided by tobacco companies. A minority of these were fitted with automated dispensers called retail vending machines. Attractive lighting and colour were often used to highlight particular products. Most retailers were being visited by industry representatives who checked displays. Some retailers also reported incentives offered to them for displaying products. The results suggest that the tobacco industry presence and control in the retail environment is significant. Tobacco companies overwhelmingly provided tobacco gantries in the shops surveyed and influenced displays through a combination of requirements and incentives. The extensive involvement of tobacco companies in providing and monitoring retail displays suggests the importance of implementing policies to end this form of advertising.

  8. SNAPSHOT SPECTRAL AND COLOR IMAGING USING A REGULAR DIGITAL CAMERA WITH A MONOCHROMATIC IMAGE SENSOR

    Directory of Open Access Journals (Sweden)

    J. Hauser

    2017-10-01

    Full Text Available Spectral imaging (SI refers to the acquisition of the three-dimensional (3D spectral cube of spatial and spectral data of a source object at a limited number of wavelengths in a given wavelength range. Snapshot spectral imaging (SSI refers to the instantaneous acquisition (in a single shot of the spectral cube, a process suitable for fast changing objects. Known SSI devices exhibit large total track length (TTL, weight and production costs and relatively low optical throughput. We present a simple SSI camera based on a regular digital camera with (i an added diffusing and dispersing phase-only static optical element at the entrance pupil (diffuser and (ii tailored compressed sensing (CS methods for digital processing of the diffused and dispersed (DD image recorded on the image sensor. The diffuser is designed to mix the spectral cube data spectrally and spatially and thus to enable convergence in its reconstruction by CS-based algorithms. In addition to performing SSI, this SSI camera is capable to perform color imaging using a monochromatic or gray-scale image sensor without color filter arrays.

  9. Smartphone snapshot mapping of skin chromophores under triple-wavelength laser illumination

    Science.gov (United States)

    Spigulis, Janis; Oshina, Ilze; Berzina, Anna; Bykov, Alexander

    2017-09-01

    Chromophore distribution maps are useful tools for skin malformation severity assessment and for monitoring of skin recovery after burns, surgeries, and other interactions. The chromophore maps can be obtained by processing several spectral images of skin, e.g., captured by hyperspectral or multispectral cameras during seconds or even minutes. To avoid motion artifacts and simplify the procedure, a single-snapshot technique for mapping melanin, oxyhemoglobin, and deoxyhemoglobin of in-vivo skin by a smartphone under simultaneous three-wavelength (448-532-659 nm) laser illumination is proposed and examined. Three monochromatic spectral images related to the illumination wavelengths were extracted from the smartphone camera RGB image data set with respect to crosstalk between the RGB detection bands. Spectral images were further processed accordingly to Beer's law in a three chromophore approximation. Photon absorption path lengths in skin at the exploited wavelengths were estimated by means of Monte Carlo simulations. The technique was validated clinically on three kinds of skin lesions: nevi, hemangiomas, and seborrheic keratosis. Design of the developed add-on laser illumination system, image-processing details, and the results of clinical measurements are presented and discussed.

  10. A snapshot of catastrophic post-disaster health expenses after Typhoon Haiyan.

    Science.gov (United States)

    Espallardo, Noel; Geroy, Lester Sam; Villanueva, Raul; Gavino, Roy; Nievera, Lucille Angela; Hall, Julie Lyn

    2015-01-01

    This paper provides a snapshot of the health-care costs, out-of-pocket expenditures and available safety nets post-Typhoon Haiyan. This descriptive study used a survey and document review to report direct and indirect health-care costs and existing financial protection mechanisms used by households in two municipalities in the Philippines at one week and at seven months post-Haiyan. Reported out-of-pocket health-care expenses were high immediately after the disaster and increased after seven months. The mean reported out-of-pocket expenses were higher than the reported average household income (US$ 24 to US$ 59). The existing local and national mechanisms for health financing were promising and should be strengthened to reduce out-of-pocket expenses and protect people from catastrophic expenditures. Longer-term mechanisms are needed to ensure financial protection, especially among the poorest, beyond three months when most free services and medicines have ended. Preparedness should include prior registration of households that would ensure protection when a disaster comes.

  11. Time-lapse crystallography snapshots of a double-strand break repair polymerase in action.

    Science.gov (United States)

    Jamsen, Joonas A; Beard, William A; Pedersen, Lars C; Shock, David D; Moon, Andrea F; Krahn, Juno M; Bebenek, Katarzyna; Kunkel, Thomas A; Wilson, Samuel H

    2017-08-15

    DNA polymerase (pol) μ is a DNA-dependent polymerase that incorporates nucleotides during gap-filling synthesis in the non-homologous end-joining pathway of double-strand break repair. Here we report time-lapse X-ray crystallography snapshots of catalytic events during gap-filling DNA synthesis by pol μ. Unique catalytic intermediates and active site conformational changes that underlie catalysis are uncovered, and a transient third (product) metal ion is observed in the product state. The product manganese coordinates phosphate oxygens of the inserted nucleotide and PP i . The product metal is not observed during DNA synthesis in the presence of magnesium. Kinetic analyses indicate that manganese increases the rate constant for deoxynucleoside 5'-triphosphate insertion compared to magnesium. The likely product stabilization role of the manganese product metal in pol μ is discussed. These observations provide insight on structural attributes of this X-family double-strand break repair polymerase that impact its biological function in genome maintenance.DNA polymerase (pol) μ functions in DNA double-strand break repair. Here the authors use time-lapse X-ray crystallography to capture the states of pol µ during the conversion from pre-catalytic to product complex and observe a third transiently bound metal ion in the product state.

  12. A Pseudorange Measurement Scheme Based on Snapshot for Base Station Positioning Receivers.

    Science.gov (United States)

    Mo, Jun; Deng, Zhongliang; Jia, Buyun; Bian, Xinmei

    2017-12-01

    Digital multimedia broadcasting signal is promised to be a wireless positioning signal. This paper mainly studies a multimedia broadcasting technology, named China mobile multimedia broadcasting (CMMB), in the context of positioning. Theoretical and practical analysis on the CMMB signal suggests that the existing CMMB signal does not have the meter positioning capability. So, the CMMB system has been modified to achieve meter positioning capability by multiplexing the CMMB signal and pseudo codes in the same frequency band. The time difference of arrival (TDOA) estimation method is used in base station positioning receivers. Due to the influence of a complex fading channel and the limited bandwidth of receivers, the regular tracking method based on pseudo code ranging is difficult to provide continuous and accurate TDOA estimations. A pseudorange measurement scheme based on snapshot is proposed to solve the problem. This algorithm extracts the TDOA estimation from the stored signal fragments, and utilizes the Taylor expansion of the autocorrelation function to improve the TDOA estimation accuracy. Monte Carlo simulations and real data tests show that the proposed algorithm can significantly reduce the TDOA estimation error for base station positioning receivers, and then the modified CMMB system achieves meter positioning accuracy.

  13. A snapshot of catastrophic post-disaster health expenses post-Haiyan

    Directory of Open Access Journals (Sweden)

    Noel Espallardo

    2015-11-01

    Full Text Available Introduction: This paper provides a snapshot of the health-care costs, out-of-pocket expenditures and available safety nets post-Typhoon Haiyan. Methods: This descriptive study used a survey and document review to report direct and indirect health-care costs and existing financial protection mechanisms used by households in two municipalities in the Philippines at one week and at seven months post-Haiyan. Results: Reported out-of-pocket health-care expenses were high immediately after the disaster and increased after seven months. The mean reported out-of-pocket expenses were higher than the reported average household income (US$ 24 to US$ 59. Discussion: The existing local and national mechanisms for health financing were promising and should be strengthened to reduce out-of-pocket expenses and protect people from catastrophic expenditures. Longer-term mechanisms are needed to ensure financial protection, especially among the poorest, beyond three months when most free services and medicines have ended. Preparedness should include prior registration of households that would ensure protection when a disaster comes.

  14. A score card for upper GI endoscopy: Evaluation of interobserver variability in examiners with various levels of experience.

    Science.gov (United States)

    Neumann, M; Friedl, S; Meining, A; Egger, K; Heldwein, W; Rey, J F; Hochberger, J; Classen, M; Hohenberger, W; Rösch, T

    2002-10-01

    In most European countries, training in GI endoscopy has largely been based on hands-on acquisition of experience in patients rather than on a structured training programme. With the development of training models systematic hands-on training in a variety of diagnostic and therapeutic endoscopy techniques was achieved. Little, however, is known about methods of objectively assessing trainees' performance. We therefore developed an assessment 'score card' for upper GI endoscopy and tested it in endoscopists with various levels of experience. The aim of the study was therefore to assess interobserver variations in the evaluation of trainees. On the basis of textbook and expert opinions a consensus group of eight experienced endoscopists developed a score card for diagnostic upper GI endoscopy with biopsy. The score card includes an assessment of the single steps of the procedure as well as of the times needed to complete each step. This score card was then evaluated in a further conference including ten experts who blindly assessed videotapes of 15 endoscopists performing upper GI endoscopy in a training bio-simulation model (the 'Erlangen Endo-Trainer'). On the basis of their previous experience (i. e. the number of endoscopies performed) these 15 endoscopists were classified into four groups: very experienced, experienced, having some experience and inexperienced. Interobserver variability (IOV) was tested for the various score card parameters (Kendall's rank-correlation coefficient 0.0-0.5 poor, 0.5-1.0 good agreement). In addition, the correlation between the score card assessment and the examiners' experience levels was analysed. Despite poor IOV results for all the parameters tested (Kendall coefficient account (correlation coefficient 0.59-0.89, p < 0.05). The score card parameters were suitable for differentiating between the four groups of examiners with different levels of endoscopic experience. As expected with scores involving subjective assessment of

  15. Investigating the Effects of Group Investigation (GI and Cooperative Integrated Reading and Comprehension (CIRC as the Cooperative Learning Techniques on Learner's Reading Comprehension

    Directory of Open Access Journals (Sweden)

    Mohammad Amin Karafkan

    2015-11-01

    Full Text Available Cooperative learning consists of some techniques for helping students work together more effectively. This study investigated the effects of Group Investigation (GI and Cooperative Integrated Reading and Composition (CIRC as cooperative learning techniques on Iranian EFL learners’ reading comprehension at an intermediate level. The participants of the study were 207 male students who studied at an intermediate level at ILI. The participants were randomly assigned into three equal groups: one control group and two experimental groups. The control group was instructed via conventional technique following an individualistic instructional approach. One experimental group received GI technique. The other experimental group received CIRC technique. The findings showed that there was a meaningful difference between the mean of the reading comprehension score of GI experimental group and CRIC experimental group. CRIC technique is more effective than GI technique in enhancing the reading comprehension test scores of students.

  16. Mis on läbilöömiseks elutähtis? / Siret Liivamägi, Ando Rehemaa, Mart Proos ... [jt.

    Index Scriptorium Estoniae

    2009-01-01

    Küsimusele vastavad Villa Benita juhatuse esimees Siret Liivamägi, registrite ja infosüsteemide keskuse direktor Ando Rehemaa, AS Favor juhatuse esimees Mart Proos, Swedbanki grupi finantsjuht Erkki Raasuke, Euroopa Komisjoni asepresident Siim Kallas

  17. The impact of a low glycemic index (GI) breakfast and snack on daily blood glucose profiles and food intake in young Chinese adult males.

    Science.gov (United States)

    Kaur, Bhupinder; Ranawana, Viren; Teh, Ai-Ling; Henry, C Jeya K

    2015-09-01

    Low glycemic index (GI) foods have been suggested to minimize large fluctuations in blood glucose levels and reduce food intake. However, the majority of studies have been conducted on Caucasian populations with limited data on Asians. The objective of this study was to investigate how the provision of a low GI breakfast and afternoon snack affected daily blood glucose profiles and food intake. In a randomized, controlled crossover non blind design, 11 healthy Chinese male adults (body mass index 22.4 ± 1.3 kg m -2 ) attended two sessions where they consumed either a high or low GI breakfast and afternoon snack, and a standardized buffet lunch. Daily changes in glycemic response (GR) were measured using the Medtronic MiniMed (Northridge, CA) iPro™2 continuous glucose monitoring system (CGMS). The GR was further calculated to obtain the incremental area under the curve (IAUC). Glycemic variability was calculated as mean amplitude of glycemic excursion (MAGE) and energy intake (kcal) was measured quantitatively at the buffet lunch. Compared to the high GI intervention, the low GI intervention significantly reduced the GR following breakfast ( p  = 0.02), lunch ( p  = 0.02) and dinner ( p  = 0.05). The low GI treatment showed a reduction in daily AUC ( p  = 0.03). There was a significant reduction in IAUC after a low GI breakfast compared to the high GI breakfast ( p  = 0.03). The low GI breakfast resulted in a significantly lower food intake at lunch and a resulting decreased energy intake of 285 kcal ( p  = 0.02). The MAGE was significantly lower during the entire low GI treatment ( p  = 0.03). Consumption of a low GI breakfast and afternoon snack was capable of attenuating 24-h blood glucose profiles, minimize glycemic excursions and reduce food intake in healthy Asian males. This simple dietary intervention may be an acceptable approach in improving overall glycemia and energy balance in Asians. NCT02340507.

  18. PÖFF-i kuldsed elamused / Rain Tolk, Hille Hanso, Elina Pähklimägi jt. ; intervjueerinud Maria Ulfsak-Šeripova

    Index Scriptorium Estoniae

    2011-01-01

    Millised on eredaimad elamused, mida PÖFF aastate jooksul pakkunud on, vastavad režissöör ja näitleja Rain Tolk, EMT üritusturunduse juht Hille Hanso, näitlejad Elina Pähklimägi, Maria Avdjuško, kunstnik August Künnapu ja EFSA välissuhete juht Tristan Priimägi

  19. Dark Energy Survey Year 1 Results: Calibration of redMaGiC Redshift Distributions in DES and SDSS from Cross-Correlations

    Energy Technology Data Exchange (ETDEWEB)

    Cawthon, R.; et al.

    2017-12-19

    We present calibrations of the redshift distributions of redMaGiC galaxies in the Dark Energy Survey Year 1 (DES Y1) and Sloan Digital Sky Survey (SDSS) DR8 data. These results determine the priors of the redshift distribution of redMaGiC galaxies, which were used for galaxy clustering measurements and as lenses for galaxy-galaxy lensing measurements in DES Y1 cosmological analyses. We empirically determine the bias in redMaGiC photometric redshift estimates using angular cross-correlations with Baryon Oscillation Spectroscopic Survey (BOSS) galaxies. For DES, we calibrate a single parameter redshift bias in three photometric redshift bins: $z \\in[0.15,0.3]$, [0.3,0.45], and [0.45,0.6]. Our best fit results in each bin give photometric redshift biases of $|\\Delta z|<0.01$. To further test the redMaGiC algorithm, we apply our calibration procedure to SDSS redMaGiC galaxies, where the statistical precision of the cross-correlation measurement is much higher due to a greater overlap with BOSS galaxies. For SDSS, we also find best fit results of $|\\Delta z|<0.01$. We compare our results to other analyses of redMaGiC photometric redshifts.

  20. Time-averaged molluscan death assemblages: Palimpsests of richness, snapshots of abundance

    Science.gov (United States)

    Kidwell, Susan M.

    2002-09-01

    Field tests that compare living communities to associated dead remains are the primary means of estimating the reliability of biological information in the fossil record; such tests also provide insights into the dynamics of skeletal accumulation. Contrary to expectations, molluscan death assemblages capture a strong signal of living species' rank-order abundances. This finding, combined with independent evidence for exponential postmortem destruction of dead cohorts, argues that, although the species richness of a death assemblage may be a time-averaged palimpsest of the habitat (molluscan death assemblages contain, on average, ˜25% more species than any single census of the local live community, after sample-size standardization), species' relative-abundance data from the same assemblage probably constitute a much higher acuity record dominated by the most recent dead cohorts (e.g., from the past few hundred years or so, rather than the several thousand years recorded by the total assemblage and usually taken as the acuity of species-richness information). The pervasive excess species richness of molluscan death assemblages requires further analysis and modeling to discriminate among possible sources. However, time averaging alone cannot be responsible unless rare species (species with low rates of dead-shell production) are collectively more durable (have longer taphonomic half-lives) than abundant species. Species richness and abundance data thus appear to present fundamentally different taphonomic qualities for paleobiological analysis. Relative- abundance information is more snapshot-like and thus taphonomically more straightforward than expected, especially compared to the complex origins of dead-species richness.

  1. A Snapshot Study of Current Practices among Sellers of Translation Services between Japanese and English

    Directory of Open Access Journals (Sweden)

    Dr. Stephen Crabbe

    2015-11-01

    Full Text Available A two-part study was launched in light of the Japan Translation Federation’s 2012 statement in its guide, 翻訳で失敗しないために翻訳発注の手引き [lit. For not getting it wrong with translation: a guide to ordering translation], that “外国語の文書を母国語に翻訳するのがプロの原則です” [lit. It is a fundamental principle that professional translators work into their native languages] (Japan Translation Federation, 2012, p. 15. The key goal is to gauge the extent to which this 2012 statement is reflected in current practices among the sellers and buyers of translation services between Japanese and English. In this paper, which describes the first part of the study, the focus is on the practices of sellers of translation services between Japanese and English: specifically, professional freelance translators. Twenty-four professional freelance translators completed an online questionnaire. The results of this questionnaire, first, suggest that current practices among sellers of translation services between Japanese and English are consistent with the Japan Translation Federation’s 2012 statement and, second, broadly support secondary literature on L1 translation (translation into the first language and L2 translation (translation into the second language. Whilst this is only a snapshot of current practices among sellers of translation services between Japanese and English, the overall results are informative. In the second, follow-up part of the study the focus will be on the current practices of buyers of translation services between Japanese and English.

  2. HUBBLE SPACE TELESCOPE SNAPSHOT SEARCH FOR PLANETARY NEBULAE IN GLOBULAR CLUSTERS OF THE LOCAL GROUP

    Energy Technology Data Exchange (ETDEWEB)

    Bond, Howard E., E-mail: heb11@psu.edu [Department of Astronomy and Astrophysics, Pennsylvania State University, University Park, PA 16802 (United States)

    2015-04-15

    Single stars in ancient globular clusters (GCs) are believed incapable of producing planetary nebulae (PNs), because their post-asymptotic-giant-branch evolutionary timescales are slower than the dissipation timescales for PNs. Nevertheless, four PNs are known in Galactic GCs. Their existence likely requires more exotic evolutionary channels, including stellar mergers and common-envelope binary interactions. I carried out a snapshot imaging search with the Hubble Space Telescope (HST) for PNs in bright Local Group GCs outside the Milky Way. I used a filter covering the 5007 Å nebular emission line of [O iii], and another one in the nearby continuum, to image 66 GCs. Inclusion of archival HST frames brought the total number of extragalactic GCs imaged at 5007 Å to 75, whose total luminosity slightly exceeds that of the entire Galactic GC system. I found no convincing PNs in these clusters, aside from one PN in a young M31 cluster misclassified as a GC, and two PNs at such large angular separations from an M31 GC that membership is doubtful. In a ground-based spectroscopic survey of 274 old GCs in M31, Jacoby et al. found three candidate PNs. My HST images of one of them suggest that the [O iii] emission actually arises from ambient interstellar medium rather than a PN; for the other two candidates, there are broadband archival UV HST images that show bright, blue point sources that are probably the PNs. In a literature search, I also identified five further PN candidates lying near old GCs in M31, for which follow-up observations are necessary to confirm their membership. The rates of incidence of PNs are similar, and small but nonzero, throughout the GCs of the Local Group.

  3. Quantifying navigational information: The catchment volumes of panoramic snapshots in outdoor scenes.

    Directory of Open Access Journals (Sweden)

    Trevor Murray

    Full Text Available Panoramic views of natural environments provide visually navigating animals with two kinds of information: they define locations because image differences increase smoothly with distance from a reference location and they provide compass information, because image differences increase smoothly with rotation away from a reference orientation. The range over which a given reference image can provide navigational guidance (its 'catchment area' has to date been quantified from the perspective of walking animals by determining how image differences develop across the ground plane of natural habitats. However, to understand the information available to flying animals there is a need to characterize the 'catchment volumes' within which panoramic snapshots can provide navigational guidance. We used recently developed camera-based methods for constructing 3D models of natural environments and rendered panoramic views at defined locations within these models with the aim of mapping navigational information in three dimensions. We find that in relatively open woodland habitats, catchment volumes are surprisingly large extending for metres depending on the sensitivity of the viewer to image differences. The size and the shape of catchment volumes depend on the distance of visual features in the environment. Catchment volumes are smaller for reference images close to the ground and become larger for reference images at some distance from the ground and in more open environments. Interestingly, catchment volumes become smaller when only above horizon views are used and also when views include a 1 km distant panorama. We discuss the current limitations of mapping navigational information in natural environments and the relevance of our findings for our understanding of visual navigation in animals and autonomous robots.

  4. Quantifying navigational information: The catchment volumes of panoramic snapshots in outdoor scenes.

    Science.gov (United States)

    Murray, Trevor; Zeil, Jochen

    2017-01-01

    Panoramic views of natural environments provide visually navigating animals with two kinds of information: they define locations because image differences increase smoothly with distance from a reference location and they provide compass information, because image differences increase smoothly with rotation away from a reference orientation. The range over which a given reference image can provide navigational guidance (its 'catchment area') has to date been quantified from the perspective of walking animals by determining how image differences develop across the ground plane of natural habitats. However, to understand the information available to flying animals there is a need to characterize the 'catchment volumes' within which panoramic snapshots can provide navigational guidance. We used recently developed camera-based methods for constructing 3D models of natural environments and rendered panoramic views at defined locations within these models with the aim of mapping navigational information in three dimensions. We find that in relatively open woodland habitats, catchment volumes are surprisingly large extending for metres depending on the sensitivity of the viewer to image differences. The size and the shape of catchment volumes depend on the distance of visual features in the environment. Catchment volumes are smaller for reference images close to the ground and become larger for reference images at some distance from the ground and in more open environments. Interestingly, catchment volumes become smaller when only above horizon views are used and also when views include a 1 km distant panorama. We discuss the current limitations of mapping navigational information in natural environments and the relevance of our findings for our understanding of visual navigation in animals and autonomous robots.

  5. MENINGKATKAN AKTIVITAS BELAJAR SISWA DENGAN MENGGUNAKAN METODE GROUP INVESTIGATION (GI PADA POKOK BAHASAN PASAR DI KELAS VIII SMP 5 KUDUS

    Directory of Open Access Journals (Sweden)

    Mutthofiyah Mutthofiyah

    2016-03-01

    Full Text Available Penelitian ini bertujuan untukmeningkatkan aktivitas belajar siswa dengan menggunakan metode group investigation (GI pada pokok bahasan pasar pada penelitian ini menggunakan penelitian tindakan kelas (PTK. Dalam penelitian ini dirancang menggunakan siklus, masing-masing siklus dengan tahapan perencanaan, pelaksanaan tindakan, observasi dan refleksi. Teknik pengumpulan data pada penelitian ini adalah dokumentasi, observasi dan tes.Hasil penelitian menunjukkan melalui meningkatkan metode group investigation (GI aktivitas siswa SMP 5 Kudus ada peningkatan yang sigifikan, dari siklus I kelas VIII F 15,8 (41,62% meningkat di siklus II menjadi 24,8 (72,9%, sedangkan di kelas VIII G siklus I 18,5 (47,04% meningkat menjadi 26,2 (74,7%; melalui penerapan metode group investigation hasil belajar siswa SMP 5 kudus meningkat sangat signifkan, ketuntasan belajar secara klasikal dari kelas VIII F pra siklus sebesar 17,64% terjadi peningkatan 47% ke siklus I dan meningkat menjadi 82,35% di siklus II. Sedangkan di kelas VII G pra siklus sebesar 22,85% meningkat 54,28% di siklus I dan meningkat menjadi 94,28% di siklus II. Saran yang peneliti berikan adalah sebagai berikut:1Kepada para guru diharapkan dapat menerapkan pembelajaran kooperatif khususnya pembelajaran kooperatif tipe Group Investigation (GI dalam proses pembelajaran ekonomi dan mata pelajaran lainya dan mengembangkannya; 2 Kepada para peneliti selanjutnya diharapkan dapat melakukan penelitian tentang penerapan model pembelajaran yang dapat membangkitkan keaktifan siswa untuk belajar ekonomi. This study aims to improve students' learning activities using group investigation (GI on the subject of markets in class VIII SMP 5 Kudus. In this study is designed to use cycles, with each cycle stages of planning, action, observation and reflection. Data collection techniques in this study is documentation, observation and tests. Results showed through improved methods of group investigation (GI junior 5 high

  6. [Interface bond and compatibility between GI-II glass/alumina composite and Vitadur alpha veneering porcelain].

    Science.gov (United States)

    Meng, Yukun; Chao, Yonglie; Liao, Yunmao

    2002-01-01

    Multiple layer techniques were commonly employed in fabricating all-ceramic restorations. Bond and compatibility between layers were vitally important for the clinical success of the restorations. The purposes of this study were to investigate the bond of the interface between the GI-II glass/alumina composite and Vitadur alpha veneering porcelain, and to study the thermal compatibility between them. Prepared a bar shaped specimen of GI-II glass/alumina composite 25 mm x 5 mm x 1 mm in size, with bottom surface pre-notched. The upper surface was veneered with Vitadur alpha veneering porcelain (0.2 mm opaque dentin and 0.6 mm dentin porcelain), then fractured and the fracture surface were examined under scanning electron microscope (SEM) and electron microprobe analyzer (EMPA) with electron beam of 10 micrometer in diameter; ten all-ceramic single crowns for an upper right central incisor were fabricated and the temperatures of thermal shock resistance were tested. SEM observation showed tight bond between the composite and the porcelain; The results of EMPA showed that penetration of Na, Al elements from glass/alumina into veneering porcelain and Si, K, Ca elements from veneering porcelain into glass/alumina occurred after sintering baking; The temperature of thermal shock resistance for anterior crowns in this study was 158 +/- 10.3 degrees C, cracks were mainly distributed in veneering porcelain with thicker layer. Chemical bond exists between the GI-II glass/alumina composite and Vitadur alpha veneering porcelain, and there is good thermal compatibility between them.

  7. Roentgenosemiotics of GI tract functional obstruction determined by birth injuries of the spinal column and spinal cord in children

    International Nuclear Information System (INIS)

    Akberov, R.F.

    1988-01-01

    Experiments on animals and the results of combined clinico-roentgenological investigation of 150 children with birth injuries of the spinal column and cord and 40 children with invagination and consequences of the cervical spine and cord, made it possible to study roentgenosemiotics and to establish pathogenetic interrelationship of natal injuries of the spinal column, spinal cord and GI tract functional obstruction in the form of polyspasm, spastic-hypo- and atonic intestinal dyskenesia, gastroesophageal reflux, aspiration pneumonia with the development of intestinal invagination

  8. Beyond MACS: A Snapshot Survey of the Most Massive Clusters of Galaxies at z>0.5

    Science.gov (United States)

    Ebeling, Harald

    2017-08-01

    Truly massive galaxy clusters play a pivotal role for a wealth of extragalactic and cosmological research topics, and SNAPshot observations of these systems are ideally suited to identify the most promising cluster targets for further, in-depth study. The power of this approach was demonstrated by ACS/WFC3 SNAPshots of X-ray selected MACS and eMACS clusters at z>0.3 obtained by us in previous Cycles (44 of them in all of F606W, F814W, F110W, and F140W). Based on these data, the CLASH MCT program selected 16 out of 25 of their targets to be MACS clusters. Similarly, all but one of the six most powerful cluster lenses selected for in-depth study by the HST Frontier Fields initiative are MACS detections, and so are 16 of the 29 z>0.3 clusters targeted by the RELICS legacy program.We propose to extend our spectacularly successful SNAPshot survey of the most X-ray luminous distant clusters to a redshift-mass regime that is poorly sampled by any other project. Targeting only extremely massive clusters at z>0.5 from the X-ray selected eMACS sample (median velocity dispersion: 1180 km/s), the proposed program will (a) identify the most powerful gravitational telescopes at yet higher redshift for the next generation of in-depth studies of the distant Universe with HST and JWST, (b) provide constraints on the mass distribution within these extreme systems, (c) help improve our understanding of the physical nature of galaxy-galaxy and galaxy-gas interactions in cluster cores, and (d) unveil Balmer Break Galaxies at z 2 and Lyman-break galaxies at z>6 as F814W dropouts.Acknowledging the broad community interest in our sample we waive our data rights for these observations.

  9. The learning curve to achieve satisfactory completion rates in upper GI endoscopy: an analysis of a national training database.

    Science.gov (United States)

    Ward, S T; Hancox, A; Mohammed, M A; Ismail, T; Griffiths, E A; Valori, R; Dunckley, P

    2017-06-01

    The aim of this study was to determine the number of OGDs (oesophago-gastro-duodenoscopies) trainees need to perform to acquire competency in terms of successful unassisted completion to the second part of the duodenum 95% of the time. OGD data were retrieved from the trainee e-portfolio developed by the Joint Advisory Group on GI Endoscopy (JAG) in the UK. All trainees were included unless they were known to have a baseline experience of >20 procedures or had submitted data for 90% trainees had attained a 95% completion rate. Total number of OGDs performed, trainee age and experience in lower GI endoscopy were factors independently associated with OGD completion. There are limited published data on the OGD learning curve. This is the largest study to date analysing the learning curve for competency acquisition. The JAG competency requirement for 200 procedures appears appropriate. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  10. Variation in gastric pH may determine kiwifruit's effect on functional GI disorder: an in vitro study.

    Science.gov (United States)

    Donaldson, Bruce; Rush, Elaine; Young, Owen; Winger, Ray

    2014-04-11

    Consumption of kiwifruit is reported to relieve symptoms of functional gastrointestinal (GI) disorder. The effect may be related to the proteases in kiwifruit. This in vitro study aimed to measure protein hydrolysis due to kiwifruit protease under gastric and duodenal conditions. A sequence of experiments incubated meat protein, with and without kiwifruit, with varying concentrations of pepsin and hydrochloric acid, at 37 °C for 60 min over the pH range 1.3-6.2 to simulate gastric digestion. Duodenal digestion was simulated by a further 120 min incubation at pH 6.4. Protein digestion efficiency was determined by comparing Kjeldahl nitrogen in pre- and post-digests. Where acid and pepsin concentrations were optimal for peptic digestion, hydrolysis was 80% effective and addition of kiwifruit made little difference. When pH was increased to 3.1 and pepsin activity reduced, hydrolysis decreased by 75%; addition of kiwifruit to this milieu more than doubled protein hydrolysis. This in vitro study has shown, when gastric pH is elevated, the addition of kiwifruit can double the rate of hydrolysis of meat protein. This novel finding supports the hypothesis that consumption of kiwifruit with a meal can increase the rate of protein hydrolysis, which may explain how kiwifruit relieves functional GI disorder.

  11. The effect of food on gastrointestinal (GI) transit of sustained-release ibuprofen tablets as evaluated by gamma scintigraphy

    International Nuclear Information System (INIS)

    Borin, M.T.; Khare, S.; Beihn, R.M.; Jay, M.

    1990-01-01

    The GI transit of radiolabeled sustained-release ibuprofen 800-mg tablets in eight healthy, fed volunteers was monitored using external gamma scintigraphy. Ibuprofen serum concentrations were determined from blood samples drawn over 36 hr following dosing. Sustained-release ibuprofen tablets containing 0.18% of 170Er2O3 (greater than 96% 170Er) in the bulk formulation were manufactured under pilot-scale conditions and were radiolabeled utilizing a neutron activation procedure which converted stable 170Er to radioactive 171Er (t1/2 = 7.5 hr). At the time of dosing, each tablet contained 50 mu Ci of 171Er. Dosage form position were reported at various time intervals. In five subjects the sustained-release tablet remained in the stomach and eroded slowly over 7-12 hr, resulting in gradual increases in small bowel radioactivity. In the remaining three subjects, the intact tablet was ejected from the stomach and a gastric residence time of approximately 4 hr was measured. This is in marked contrast to a previous study conducted in fasted volunteers in which gastric retention time ranged from 10 to 60 min. Differences in GI transit between fed and fasted volunteers had little effect on ibuprofen bioavailability. AUC and Tmax were unaltered and Cmax was increased by 24%, which is in agreement with results from a previous, crossover-design food effect study

  12. A GI Proposal to Display ECG Digital Signals Wirelessly Real-time Transmitted onto a Remote PC

    Directory of Open Access Journals (Sweden)

    Marius Corneliu Rosu

    2018-03-01

    Full Text Available The sensors, as wireless communication system, comply the 7-layer model Open Systems Interconnection (OSI. In this paper, a point-to-point transmission model was used. The ECG signal is transmitted from the Router Sensor (RS to an end Coordinator Node (CN plugged-in to the laptop via USB port; RS acquires ECG signal in analogical mode, and is also responsible with sampling, quantization and sending it wirelessly direct to CN. The distance between RS and CN is a single-hop transmission, and does not exceed the range of the XBeeS2Pro transceivers. The communication protocol is ZigBee. Remote viewing of the transmitted signal is performed on a Graphical Interface (GI written under MATLAB, after the signal has been digitized; the choice of MATLAB was motivated by future developments. Particular aspects will be highlighted, so that the reader to be edified about the results obtained during laboratory experiments. Recording demonstrate that the purpose exposed in title has been reached: Direct link in Real-Time was established, and the digital ECG signal received is reconstituted accurately on MATLAB GI; signal received on laptop is compared with the analog signal displayed on oscilloscope.

  13. Variation in Gastric pH May Determine Kiwifruit’s Effect on Functional GI Disorder: An in Vitro Study

    Directory of Open Access Journals (Sweden)

    Bruce Donaldson

    2014-04-01

    Full Text Available Consumption of kiwifruit is reported to relieve symptoms of functional gastrointestinal (GI disorder. The effect may be related to the proteases in kiwifruit. This in vitro study aimed to measure protein hydrolysis due to kiwifruit protease under gastric and duodenal conditions. A sequence of experiments incubated meat protein, with and without kiwifruit, with varying concentrations of pepsin and hydrochloric acid, at 37 °C for 60 min over the pH range 1.3–6.2 to simulate gastric digestion. Duodenal digestion was simulated by a further 120 min incubation at pH 6.4. Protein digestion efficiency was determined by comparing Kjeldahl nitrogen in pre- and post-digests. Where acid and pepsin concentrations were optimal for peptic digestion, hydrolysis was 80% effective and addition of kiwifruit made little difference. When pH was increased to 3.1 and pepsin activity reduced, hydrolysis decreased by 75%; addition of kiwifruit to this milieu more than doubled protein hydrolysis. This in vitro study has shown, when gastric pH is elevated, the addition of kiwifruit can double the rate of hydrolysis of meat protein. This novel finding supports the hypothesis that consumption of kiwifruit with a meal can increase the rate of protein hydrolysis, which may explain how kiwifruit relieves functional GI disorder.

  14. X-ray backscatter imaging for radiography by selective detection and snapshot: Evolution, development, and optimization

    Science.gov (United States)

    Shedlock, Daniel

    Compton backscatter imaging (CBI) is a single-sided imaging technique that uses the penetrating power of radiation and unique interaction properties of radiation with matter to image subsurface features. CBI has a variety of applications that include non-destructive interrogation, medical imaging, security and military applications. Radiography by selective detection (RSD), lateral migration radiography (LMR) and shadow aperture backscatter radiography (SABR) are different CBI techniques that are being optimized and developed. Radiography by selective detection (RSD) is a pencil beam Compton backscatter imaging technique that falls between highly collimated and uncollimated techniques. Radiography by selective detection uses a combination of single- and multiple-scatter photons from a projected area below a collimation plane to generate an image. As a result, the image has a combination of first- and multiple-scatter components. RSD techniques offer greater subsurface resolution than uncollimated techniques, at speeds at least an order of magnitude faster than highly collimated techniques. RSD scanning systems have evolved from a prototype into near market-ready scanning devices for use in a variety of single-sided imaging applications. The design has changed to incorporate state-of-the-art detectors and electronics optimized for backscatter imaging with an emphasis on versatility, efficiency and speed. The RSD system has become more stable, about 4 times faster, and 60% lighter while maintaining or improving image quality and contrast over the past 3 years. A new snapshot backscatter radiography (SBR) CBI technique, shadow aperture backscatter radiography (SABR), has been developed from concept and proof-of-principle to a functional laboratory prototype. SABR radiography uses digital detection media and shaded aperture configurations to generate near-surface Compton backscatter images without scanning, similar to how transmission radiographs are taken. Finally, a

  15. Smoking behavior among patients and staff: a snapshot from a major metropolitan hospital in Melbourne, Australia

    Directory of Open Access Journals (Sweden)

    Rahman MA

    2014-01-01

    Full Text Available Muhammad Aziz Rahman,1,2 Andrew M Wilson,2–4 Rhonda Sanders,3 David Castle,2–4 Karen Daws,3 David R Thompson,2 Chantal F Ski,2 Sarah Matthews,3 Christine Wright,2 Linda Worrall-Carter1–31St Vincent's Centre for Nursing Research (SVCNR, Australian Catholic University, Melbourne, VIC, Australia; 2The Cardiovascular Research Centre (CvRC, Australian Catholic University, Melbourne, VIC, Australia; 3St Vincent's Hospital, Melbourne, VIC, Australia; 4The University of Melbourne, Melbourne, VIC, AustraliaBackground: A cross-sectional study was conducted to provide a snapshot of smoking behavior among staff and patients at a major metropolitan hospital in Melbourne.Methods: Patients and staff were surveyed using a questionnaire exploring demographics, nicotine dependence (Fagerstrom test, readiness to quit, and preference for smoking cessation options.Results: A total of 1496 people were screened within 2 hours; 1,301 participated (1,100 staff, 199 patients. Mean age was 42 years, 68% were female. There were 113 (9% current smokers and 326 (25% ex-smokers. Seven percent of the staff were current smokers compared with 19% of the patients. The Fagerstrom test showed that 47% of patients who smoked were moderately nicotine dependent compared with 21% of staff. A third of the staff who smoked did not anticipate health problems related to smoking. Most patients (79% who smoked disagreed that their current health problems were related to smoking. Although more than half of the current smokers preferred pharmacotherapy, one in two of them did not prefer behavior counseling; with consistent results among staff and patients. Multivariate analyses showed that patients were three times more likely (odds ratio 3.0, 95% confidence interval 1.9–4.7 to smoke than staff.Conclusion: This study reports lower prevalence of smoking among hospital staff compared with national data. It also indicates an under-appreciation of health effects of smoking, and a

  16. Secretory Products of the Human GI Tract Microbiome and Their Potential Impact on Alzheimer's Disease (AD: Detection of Lipopolysaccharide (LPS in AD Hippocampus

    Directory of Open Access Journals (Sweden)

    Yuhai Zhao

    2017-07-01

    Full Text Available Although the potential contribution of the human gastrointestinal (GI tract microbiome to human health, aging, and disease is becoming increasingly acknowledged, the molecular mechanics and signaling pathways of just how this is accomplished is not well-understood. Major bacterial species of the GI tract, such as the abundant Gram-negative bacilli Bacteroides fragilis (B. fragilis and Escherichia coli (E. coli, secrete a remarkably complex array of pro-inflammatory neurotoxins which, when released from the confines of the healthy GI tract, are pathogenic and highly detrimental to the homeostatic function of neurons in the central nervous system (CNS. For the first time here we report the presence of bacterial lipopolysaccharide (LPS in brain lysates from the hippocampus and superior temporal lobe neocortex of Alzheimer's disease (AD brains. Mean LPS levels varied from two-fold increases in the neocortex to three-fold increases in the hippocampus, AD over age-matched controls, however some samples from advanced AD hippocampal cases exhibited up to a 26-fold increase in LPS over age-matched controls. This “Perspectives” paper will further highlight some very recent research on GI tract microbiome signaling to the human CNS, and will update current findings that implicate GI tract microbiome-derived LPS as an important internal contributor to inflammatory degeneration in the CNS.

  17. Snapshots of simulation: creative strategies used by Australian educators to enhance simulation learning experiences for nursing students.

    Science.gov (United States)

    McAllister, Margaret; Levett-Jones, Tracy; Downer, Teresa; Harrison, Penelope; Harvey, Theresa; Reid-Searl, Kerry; Lynch, Kathy; Arthur, Carol; Layh, Janice; Calleja, Pauline

    2013-11-01

    Simulation in nursing is a flourishing area for nurse educators' practice. Defined as learning that amplifies, mimics or replaces real-life clinical situations, simulation aims to give students opportunity to reason through a clinical problem and make decisions, without the potential for harming actual patients. Educators in nursing are contributing to simulation learning in diverse and creative ways. Yet much of their craft is not being widely disseminated because educators are not always confident in publishing their work. This paper aims to stimulate creative development in simulation by providing short summaries, or snapshots, of diverse approaches that nurse educators are using. The objective is to inspire others to share other ideas in development or in practice that are improving learning for nursing students and practitioners, so that simulation scholarship is advanced. The snapshots presented range from approaches that: better support educators to attend to the whole process of simulation education, give students quick access to short skill-based videos, orientate students to the laboratory environment, harness the power of the group to develop documentation skills, use simulation to enrich lectures, develop multidisciplinary knowledge, and finally, which teach therapeutic communication with children in a fun and imaginative way. Copyright © 2013 Elsevier Ltd. All rights reserved.

  18. Herpes simplex virus immunoglobulin G Fc receptor activity depends on a complex of two viral glycoproteins, gE and gI

    International Nuclear Information System (INIS)

    Johnson, D.C.; Ligas, M.W.; Frame, M.C.; Cross, A.M.; Stow, N.D.

    1988-01-01

    Evidence was recently presented that herpes simplex virus type 1 (HSV-1) immunoglobulin G (IgG) Fc receptors are composed of a complex containing a previously described glycoprotein, gE, and a novel virus-induced polypeptide, provisionally named g70. Using a monoclonal antibody designated 3104, which recognizes g70, in conjunction with antipeptide sera and virus mutants unable to express g70 or gE, the authors have mapped the gene encoding g70 to the US7 open reading frame of HSV-1 adjacent to the gE gene. Therefore, g70 appears to be identical to a recently described polypeptide which was named gI. Under mildly denaturing conditions, monoclonal antibody 3104 precipitated both gI and gE from extracts of HSV-1-infected cells. In addition, rabbit IgG precipitated the gE-gI complex from extracts of cells transfected with a fragment of HSV-1 DNA containing the gI, gE, and US9 genes. Cells infected with mutant viruses which were unable to express gE or gI did not bind radiolabeled IgG; however, cells coinfected with two viruses, one unable to express gE and the other unable to express gI, bound levels of IgG approaching those observed with wild-type viruses. These results further support the hypothesis that gE and gI form a complex which binds IgG by the Fc domain and that neither polypeptide alone can bind IgG

  19. On the Two-Moment Approximation of the Discrete-Time GI/G/1 Queue with a Single Vacation

    Directory of Open Access Journals (Sweden)

    Doo Ho Lee

    2016-01-01

    Full Text Available We consider a discrete-time GI/G/1 queue in which the server takes exactly one vacation each time the system becomes empty. The interarrival times of arriving customers, the service times, and the vacation times are all generic discrete random variables. Under our study, we derive an exact transform-free expression for the stationary system size distribution through the modified supplementary variable technique. Utilizing obtained results, we introduce a simple two-moment approximation for the system size distribution. From this, approximations for the mean system size along with the system size distribution could be obtained. Finally, some numerical examples are given to validate the proposed approximation method.

  20. The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB-fold

    International Nuclear Information System (INIS)

    Das, Debanu; Kozbial, Piotr; Han, Gye Won; Carlton, Dennis; Jaroszewski, Lukasz; Abdubek, Polat; Astakhova, Tamara; Axelrod, Herbert L.; Bakolitsa, Constantina; Chen, Connie; Chiu, Hsiu-Ju; Chiu, Michelle; Clayton, Thomas; Deller, Marc C.; Duan, Lian; Ellrott, Kyle; Elsliger, Marc-André; Ernst, Dustin; Farr, Carol L.; Feuerhelm, Julie; Grzechnik, Anna; Grant, Joanna C.; Jin, Kevin K.; Johnson, Hope A.; Klock, Heath E.; Knuth, Mark W.; Krishna, S. Sri; Kumar, Abhinav; Marciano, David; McMullan, Daniel; Miller, Mitchell D.; Morse, Andrew T.; Nigoghossian, Edward; Nopakun, Amanda; Okach, Linda; Oommachen, Silvya; Paulsen, Jessica; Puckett, Christina; Reyes, Ron; Rife, Christopher L.; Sefcovic, Natasha; Tien, Henry J.; Trame, Christine B.; Bedem, Henry van den; Weekes, Dana; Wooten, Tiffany; Xu, Qingping; Hodgson, Keith O.; Wooley, John; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A.

    2009-01-01

    KPN03535 is a protein unique to K. pneumoniae. The crystal structure reveals that KPN03535 represents a novel variant of the OB-fold and is likely to be a DNA-binding lipoprotein. KPN03535 (gi|152972051) is a putative lipoprotein of unknown function that is secreted by Klebsiella pneumoniae MGH 78578. The crystal structure reveals that despite a lack of any detectable sequence similarity to known structures, it is a novel variant of the OB-fold and structurally similar to the bacterial Cpx-pathway protein NlpE, single-stranded DNA-binding (SSB) proteins and toxins. K. pneumoniae MGH 78578 forms part of the normal human skin, mouth and gut flora and is an opportunistic pathogen that is linked to about 8% of all hospital-acquired infections in the USA. This structure provides the foundation for further investigations into this divergent member of the OB-fold family

  1. Surdegsbröd och jästbröd : skillnad i smak och GI-värde

    OpenAIRE

    Björkman, Andreas; Jeppsson, Julia

    2015-01-01

    Inledning: Surdeg är idag en trend som fångats av många och de flesta bagerier ochdagligvarubutiker säljer bröd som kallas för surdegsbröd. Ett traditionellt surdegsbröd är ettbröd där surdegen används som enda hävningsmedel i brödet. Syfte: Syftet var att undersöka skillnader i sensoriska egenskaper, utifrån ettkonsumentperspektiv, samt GI-värde mellan surdegsbröd, jästbröd och bröd bakat på bådesurdeg och jäst. Material och metod: Metoderna som användes var två olika konsumenttester för att...

  2. Extraction of multi-scale landslide morphological features based on local Gi* using airborne LiDAR-derived DEM

    Science.gov (United States)

    Shi, Wenzhong; Deng, Susu; Xu, Wenbing

    2018-02-01

    For automatic landslide detection, landslide morphological features should be quantitatively expressed and extracted. High-resolution Digital Elevation Models (DEMs) derived from airborne Light Detection and Ranging (LiDAR) data allow fine-scale morphological features to be extracted, but noise in DEMs influences morphological feature extraction, and the multi-scale nature of landslide features should be considered. This paper proposes a method to extract landslide morphological features characterized by homogeneous spatial patterns. Both profile and tangential curvature are utilized to quantify land surface morphology, and a local Gi* statistic is calculated for each cell to identify significant patterns of clustering of similar morphometric values. The method was tested on both synthetic surfaces simulating natural terrain and airborne LiDAR data acquired over an area dominated by shallow debris slides and flows. The test results of the synthetic data indicate that the concave and convex morphologies of the simulated terrain features at different scales and distinctness could be recognized using the proposed method, even when random noise was added to the synthetic data. In the test area, cells with large local Gi* values were extracted at a specified significance level from the profile and the tangential curvature image generated from the LiDAR-derived 1-m DEM. The morphologies of landslide main scarps, source areas and trails were clearly indicated, and the morphological features were represented by clusters of extracted cells. A comparison with the morphological feature extraction method based on curvature thresholds proved the proposed method's robustness to DEM noise. When verified against a landslide inventory, the morphological features of almost all recent (historical (> 10 years) landslides were extracted. This finding indicates that the proposed method can facilitate landslide detection, although the cell clusters extracted from curvature images should

  3. Isoproterenol induces vascular oxidative stress and endothelial dysfunction via a Giα-coupled β2-adrenoceptor signaling pathway.

    Directory of Open Access Journals (Sweden)

    Ana P Davel

    Full Text Available OBJECTIVE: Sustained β-adrenergic stimulation is a hallmark of sympathetic hyperactivity in cardiovascular diseases. It is associated with oxidative stress and altered vasoconstrictor tone. This study investigated the β-adrenoceptor subtype and the signaling pathways implicated in the vascular effects of β-adrenoceptor overactivation. METHODS AND RESULTS: Mice lacking the β1- or β2-adrenoceptor subtype (β1KO, β2KO and wild-type (WT were treated with isoproterenol (ISO, 15 μg.g(-1 x day(-1, 7 days. ISO significantly enhanced the maximal vasoconstrictor response (Emax of the aorta to phenylephrine in WT (+34% and β1KO mice (+35% but not in β2KO mice. The nitric oxide synthase (NOS inhibitor L-NAME abolished the differences in phenylephrine response between the groups, suggesting that ISO impaired basal NO availability in the aorta of WT and β1KO mice. Superoxide dismutase (SOD, pertussis toxin (PTx or PD 98,059 (p-ERK 1/2 inhibitor incubation reversed the hypercontractility of aortic rings from ISO-treated WT mice; aortic contraction of ISO-treated β2KO mice was not altered. Immunoblotting revealed increased aortic expression of Giα-3 protein (+50% and phosphorylated ERK1/2 (+90% and decreased eNOS dimer/monomer ratio in ISO-treated WT mice. ISO enhanced the fluorescence response to dihydroethidium (+100% in aortas from WT mice, indicating oxidative stress that was normalized by SOD, PTx and L-NAME. The ISO effects were abolished in β2KO mice. CONCLUSIONS: The β2-adrenoceptor/Giα signaling pathway is implicated in the enhanced vasoconstrictor response and eNOS uncoupling-mediated oxidative stress due to ISO treatment. Thus, long-term β2-AR activation might results in endothelial dysfunction.

  4. Substrate-Guided Front-Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N-Acetylgalactosaminyltransferase 2

    DEFF Research Database (Denmark)

    Lira-Navarrete, Erandi; Iglesias-Fernández, Javier; Zandberg, Wesley F

    2014-01-01

    of structural snapshots of the enzyme during the catalytic cycle and combine these with quantum-mechanics/molecular-mechanics (QM/MM) metadynamics to unravel the catalytic mechanism of this retaining enzyme at the atomic-electronic level of detail. Our study provides a detailed structural rationale...

  5. Implementation and Impacts of Pay-for-Performance: The 2010 Teacher Incentive Fund (TIF) Grantees after Three Years. NCEE Study Snapshot. NCEE 2016-2006

    Science.gov (United States)

    Wellington, Alison; Chiang, Hanley; Hallgren, Kristin; Speroni, Cecilia; Herrmann, Mariesa; Burkander, Paul

    2016-01-01

    The Teacher Incentive Fund (TIF) provides grants to support performance-based compensation systems for teachers and principals in high-need schools. The goal of the grants is to increase the number of high-performing teachers in high-need schools by rewarding educators for improving students' achievement. The report on which this snapshot is based…

  6. Refined Use of Satellite Aerosol Optical Depth Snapshots to Constrain Biomass Burning Emissions in the GOCART Model

    Science.gov (United States)

    Petrenko, Mariya; Kahn, Ralph; Chin, Mian; Limbacher, James

    2017-10-01

    Simulations of biomass burning (BB) emissions in global chemistry and aerosol transport models depend on external inventories, which provide location and strength for BB aerosol sources. Our previous work shows that to first order, satellite snapshots of aerosol optical depth (AOD) near the emitted smoke plume can be used to constrain model-simulated AOD, and effectively, the smoke source strength. We now refine the satellite-snapshot method and investigate where applying simple multiplicative emission adjustment factors alone to the widely used Global Fire Emission Database version 3 emission inventory can achieve regional-scale consistency between Moderate Resolution Imaging Spectroradiometer (MODIS) AOD snapshots and the Goddard Chemistry Aerosol Radiation and Transport model. The model and satellite AOD are compared globally, over a set of BB cases observed by the MODIS instrument during the 2004, and 2006-2008 biomass burning seasons. Regional discrepancies between the model and satellite are diverse around the globe yet quite consistent within most ecosystems. We refine our approach to address physically based limitations of our earlier work (1) by expanding the number of fire cases from 124 to almost 900, (2) by using scaled reanalysis-model simulations to fill missing AOD retrievals in the MODIS observations, (3) by distinguishing the BB components of the total aerosol load from background aerosol in the near-source regions, and (4) by including emissions from fires too small to be identified explicitly in the satellite observations. The small-fire emission adjustment shows the complimentary nature of correcting for source strength and adding geographically distinct missing sources. Our analysis indicates that the method works best for fire cases where the BB fraction of total AOD is high, primarily evergreen or deciduous forests. In heavily polluted or agricultural burning regions, where smoke and background AOD values tend to be comparable, this approach

  7. Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry

    International Nuclear Information System (INIS)

    Carletti, Eugenie; Santoni, Gianluca; Colletier, Jacques-Philippe; Schopfer, Lawrence M.; Lockridge, Oksana; Masson, Patrick; Nachon, Florian; Weik, Martin

    2013-01-01

    Tri-o-cresyl-phosphate (TOCP) is a common additive in jet engine lubricants and hydraulic fluids suspected to have a role in aero-toxic syndrome in humans. TOCP is metabolized to cresyl saligenin phosphate (CBDP), a potent irreversible inhibitor of butyrylcholinesterase (BChE), a natural bio-scavenger present in the bloodstream, and acetylcholinesterase (AChE), the off-switch at cholinergic synapses. Mechanistic details of cholinesterase (ChE) inhibition have, however, remained elusive. Also, the inhibition of AChE by CBDP is unexpected, from a structural standpoint, i.e., considering the narrowness of AChE active site and the bulkiness of CBDP. In the following, we report on kinetic X-ray crystallography experiments that provided 2.7-3.3 Angstroms snapshots of the reaction of CBDP with mouse AChE and human BChE. The series of crystallographic snapshots reveals that AChE and BChE react with the opposite enantiomers and that an induced-fit rearrangement of Phe297 enlarges the active site of AChE upon CBDP binding. Mass spectrometry analysis of aging in either H 2 16 O or H 2 18 O furthermore allowed us to identify the inhibition steps, in which water molecules are involved, thus providing insights into the mechanistic details of inhibition. X-ray crystallography and mass spectrometry show the formation of an aged end product formed in both AChE and BChE that cannot be reactivated by current oxime-based therapeutics. Our study thus shows that only prophylactic and symptomatic treatments are viable to counter the inhibition of AChE and BChE by CBDP. (authors)

  8. CHANDRA OBSERVATIONS OF 3C RADIO SOURCES WITH z < 0.3. II. COMPLETING THE SNAPSHOT SURVEY

    Energy Technology Data Exchange (ETDEWEB)

    Massaro, F. [SLAC National Laboratory and Kavli Institute for Particle Astrophysics and Cosmology, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States); Tremblay, G. R. [European Southern Observatory, Karl-Schwarzschild-Str. 2, D-85748 Garching bei Muenchen (Germany); Harris, D. E.; O' Dea, C. P. [Smithsonian Astrophysical Observatory, 60 Garden Street, Cambridge, MA 02138 (United States); Kharb, P.; Axon, D. [Department of Physics, Rochester Institute of Technology, Carlson Center for Imaging Science 76-3144, 84 Lomb Memorial Dr., Rochester, NY 14623 (United States); Balmaverde, B.; Capetti, A. [INAF-Osservatorio Astrofisico di Torino, Strada Osservatorio 20, I-10025 Pino Torinese (Italy); Baum, S. A. [Carlson Center for Imaging Science 76-3144, 84 Lomb Memorial Dr., Rochester, NY 14623 (United States); Chiaberge, M.; Macchetto, F. D.; Sparks, W. [Space Telescope Science Institute, 3700 San Martine Drive, Baltimore, MD 21218 (United States); Gilli, R. [INAF-Osservatorio Astronomico di Bologna, Via Ranzani 1, I-40127 Bologna (Italy); Giovannini, G. [INAF-Istituto di Radioastronomia di Bologna, Via Gobetti 101, I-40129 Bologna (Italy); Grandi, P.; Torresi, E. [INAF-IASF-Istituto di Astrofisica Spaziale e fisica Cosmica di Bologna, Via P. Gobetti 101, I-40129 Bologna (Italy); Risaliti, G. [INAF-Osservatorio Astronomico di Arcetri, Largo E. Fermi 5, I-50125 Firenze (Italy)

    2012-12-15

    We report on the second round of Chandra observations of the 3C snapshot survey developed to observe the complete sample of 3C radio sources with z < 0.3 for 8 ks each. In the first paper, we illustrated the basic data reduction and analysis procedures performed for the 30 sources of the 3C sample observed during Chandra Cycle 9, while here we present the data for the remaining 27 sources observed during Cycle 12. We measured the X-ray intensity of the nuclei and of any radio hot spots and jet features with associated X-ray emission. X-ray fluxes in three energy bands, i.e., soft, medium, and hard, for all the sources analyzed are also reported. For the stronger nuclei, we also applied the standard spectral analysis, which provides the best-fit values of the X-ray spectral index and absorbing column density. In addition, a detailed analysis of bright X-ray nuclei that could be affected by pile-up has been performed. X-ray emission was detected for all the nuclei of the radio sources in our sample except for 3C 319. Among the current sample, there are two compact steep spectrum radio sources, two broad-line radio galaxies, and one wide angle tail radio galaxy, 3C 89, hosted in a cluster of galaxies clearly visible in our Chandra snapshot observation. In addition, we also detected soft X-ray emission arising from the galaxy cluster surrounding 3C 196.1. Finally, X-ray emission from hot spots has been found in three FR II radio sources and, in the case of 3C 459, we also report the detection of X-ray emission associated with the eastern radio lobe as well as X-ray emission cospatial with radio jets in 3C 29 and 3C 402.

  9. Uudised : Paavo Järvi debüüt Berliini Filharmoonikutega. Paul Mägi dirigeeris Helikonis. Arvo Volmer tegi Soomes aasta plaadi / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2000-01-01

    P. Järvi ootamatust debüüdist Berliini Filharmoonikute ees ئ dirigent asendas haigestunud Daniel Barenboimi. Seoses Moskva ooperiteatri "Helikon" 10. aastapäevaga dirigeeris seal P. Mägi. Soome Yleisradio aasta plaadiks valiti Alba Recordsi poolt välja antud CD Leevi Madetoja sümfooniliste teostega, dirigent A. Volmer

  10. Study of relationship of selenium concentration in blood components and tumor tissues of breast and GI tract cancers using neutron activation analysis technique

    International Nuclear Information System (INIS)

    Othman, I.; Bakir, M. A.; Yassine, T.; Sarhel, A.

    2001-12-01

    The purpose of this study was to investigate the relationship between selenium (Se) concentration in blood components and tumour tissues of breast and GI tract cancers using neutron activation analysis. red blood cell (RBC) and serum Se concentrations were determined in 50 healthy volunteers aged 25-84 years, 70 breast cancer patients aged 25-70 years and 34 GI tract cancer patients aged 31-85 years, Se levels were also determined in malignant and adjacent normal tissues from breast cancer and GI tract cancer patients. The results showed that Se concentrations in serum and RBC were significantly lower among breast and GI cancer compared to healthy volunteers. The results also showed that Se concentrations were significantly higher in the cancer tissues compared to adjacent normal tissues. These data have shown a relationship between selenium status in blood components and both cancer. selenium is enriched in cancer tissue, possibly in an effort of the body to inhibit the growth of tumours. (author)

  11. Mis saab eesti gümnaasiumist? / Igor Garšnek, Linnar Priimägi, Tiiu Purdelo ; vestluse pani kirja Raivo Juurak

    Index Scriptorium Estoniae

    Garšnek, Igor, 1958-

    2008-01-01

    Riigikirjandi drillimise asemel on vaja hakata gümnaasiumis süvendatult õppima valikaineid, leiavad TLÜ õppejõud Linnar Priimägi, Eesti Kunstiakadeemia õppejõud Igor Garšnek ja SA Õiguskolledži asutaja Tiiu Purdelo

  12. Tarbijate õiguste kaitse Euroopa müügiõiguse eelnõus: kas kõrgem tase Eesti tarbija jaoks? / Karin Sein

    Index Scriptorium Estoniae

    Sein, Karin, 1974-

    2013-01-01

    Euroopa Komisjoni ettepanekust luua vabatahtlik ühine Euroopa müügiõigus (EÜM) ning Eestis kehtivast regulatsioonist tulenevalt võlaõigusseadusest. Artikkel põhineb 32. Eesti õigusteadlaste päevadel peetud ettekandel, mille autor pidas Tartus 4. oktoobril 2012

  13. Inhibition of overexpression of Giα proteins and nitroxidative stress contribute to sodium nitroprusside-induced attenuation of high blood pressure in SHR.

    Science.gov (United States)

    Hossain, Ekhtear; Sarkar, Oli; Li, Yuan; Anand-Srivastava, Madhu B

    2018-03-01

    We earlier showed that vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) exhibit enhanced expression of Giα proteins which was attributed to the decreased levels of nitric oxide (NO), because elevation of the intracellular levels of NO by NO donors; sodium nitroprusside (SNP) and S-Nitroso-N-acetyl-DL-penicillamine (SNAP), attenuated the enhanced expression of Giα proteins. Since the enhanced expression of Giα proteins is implicated in the pathogenesis of hypertension, the present study was undertaken to investigate if treatment of SHR with SNP could also attenuate the development of high blood pressure (BP) and explore the underlying molecular mechanisms. Intraperitoneal injection of SNP at a concentration of 0.5 mg/kg body weight twice a week for 2 weeks into SHR attenuated the high blood pressure by about 80 mmHg without affecting the BP in WKY rats. SNP treatment also attenuated the enhanced levels of superoxide anion (O 2 - ), hydrogen peroxide (H 2 O 2 ), peroxynitrite (ONOO - ), and NADPH oxidase activity in VSMC from SHR to control levels. In addition, the overexpression of different subunits of NADPH oxidase; Nox-1, Nox-2, Nox-4, P 22phox , and P 47phox , and Giα proteins in VSMC from SHR were also attenuated by SNP treatment. On the other hand, SNP treatment augmented the decreased levels of intracellular NO, eNOS, and cGMP in VSMC from SHR. These results suggest that SNP treatment attenuates the development of high BP in SHR through the elevation of intracellular levels of cGMP and inhibition of the enhanced levels of Giα proteins and nitroxidative stress. © 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

  14. Analysing the spatial patterns of livestock anthrax in Kazakhstan in relation to environmental factors: a comparison of local (Gi* and morphology cluster statistics

    Directory of Open Access Journals (Sweden)

    Ian T. Kracalik

    2012-11-01

    Full Text Available We compared a local clustering and a cluster morphology statistic using anthrax outbreaks in large (cattle and small (sheep and goats domestic ruminants across Kazakhstan. The Getis-Ord (Gi* statistic and a multidirectional optimal ecotope algorithm (AMOEBA were compared using 1st, 2nd and 3rd order Rook contiguity matrices. Multivariate statistical tests were used to evaluate the environmental signatures between clusters and non-clusters from the AMOEBA and Gi* tests. A logistic regression was used to define a risk surface for anthrax outbreaks and to compare agreement between clustering methodologies. Tests revealed differences in the spatial distribution of clusters as well as the total number of clusters in large ruminants for AMOEBA (n = 149 and for small ruminants (n = 9. In contrast, Gi* revealed fewer large ruminant clusters (n = 122 and more small ruminant clusters (n = 61. Significant environmental differences were found between groups using the Kruskall-Wallis and Mann- Whitney U tests. Logistic regression was used to model the presence/absence of anthrax outbreaks and define a risk surface for large ruminants to compare with cluster analyses. The model predicted 32.2% of the landscape as high risk. Approximately 75% of AMOEBA clusters corresponded to predicted high risk, compared with ~64% of Gi* clusters. In general, AMOEBA predicted more irregularly shaped clusters of outbreaks in both livestock groups, while Gi* tended to predict larger, circular clusters. Here we provide an evaluation of both tests and a discussion of the use of each to detect environmental conditions associated with anthrax outbreak clusters in domestic livestock. These findings illustrate important differences in spatial statistical methods for defining local clusters and highlight the importance of selecting appropriate levels of data aggregation.

  15. Studi Pengaruh Pemasangan NGR 40 Ohm pada Uprating Transformator 2 GI Gianyar Terhadap Gangguan Hubung Singkat 1 Phasa Tanah

    Directory of Open Access Journals (Sweden)

    Arya Surya Darma

    2017-08-01

    Full Text Available Along with the development of ever-increasing burden on the GI Gianyar then the transformer unit 2 with a capacity of 30 MVA will be uprating with a capacity of 60 MVA transformer. To maintain the continuity and reliability of the flow of electrical power to the consumer , NGR (Neutral Grounding Resistance and relay SBEF is used as the safety equipment of the short circuit 1 phase to ground was not in to the neutral point of the transformer. Uprating of transformers that have been done changes on 1 phase fault current to ground when using a direct earthing systems with a value to become 1838.21 A. While the value of the short-circuit current 1 phase to ground after pairing NGR 40 Ohm value is fixed at 288.675 A, so that the current setting and time relay SBEF fixed at 90 A and 7.067 seconds. The analysis result from the effect of installation NGR and rele SBEF on the transformer 60 MVA against short circuit 1 phase to ground has the ability good protection for the value of the fault current is able to be reduced from 1838,21 A into 288.675 A after pairing NGR 40 Ohm and time is needed SBEF to handle distractions 7.067 seconds. Intisari- Seiring dengan perkembangan beban yang terus meningkat di GI Gianyar maka transformator unit 2 berkapasitas 30 MVA akan di lakukan uprating (penggantian dengan transformator berkapasitas 60 MVA. Untuk menjaga kontinyuitas dan keandalan aliran daya listrik sampai ke konsumen (beban, NGR (Neutral Grounding Resistance dan rele SBEF dipergunakan sebagai peralatan pengaman dari gangguan hubung singkat phasa tanah agar arus gangguan 1 phasa ke tanah tidak sampai mengalir ke titik netral transformator. Dari uprating transformator yang sudah di lakukan terjadi perubahan pada arus gangguan 1 phasa ke tanah jika menggunakan sistem pentanahan langsung (solid grounding menjadi 1838,21 A. Sedangkan nilai dari arus hubung singkat 1 phasa ke tanah setelah dipasangkan NGR 40 Ohm nilainya tetap sebesar 288,675 A

  16. TU-H-CAMPUS-TeP2-02: FLASH Irradiation Improves the Therapeutic Index Following GI Tract Irradiation

    International Nuclear Information System (INIS)

    Schueler, E; Trovati, S; King, G; Lartey, F; Rafat, M; Loo, B; Maxim, P

    2016-01-01

    Purpose: To investigate and characterize the radiobiological effectiveness of very high dose rate radiotherapy (FLASH) compared to conventional irradiation in an in vivo model. Methods: The gastrointestinal (GI) tract of C57BL/6 mice were irradiated with doses ranging between 10 and 18 Gy using a custom stereotactic jig. A Varian Clinac 21EX was modified to allow dose rates ranging from 0.05 to 240 Gy/s at the position of the mirror. With the gantry at 180 degrees, the jig holding the individual animals was placed above the mirror to take advantage of the reduced source to target distance. Mice were irradiated with 20MeV electrons. Following irradiation, the mice were monitored twice daily for morbidity and daily for weight changes. Results: Mice irradiated with FLASH irradiation had lower weight loss compared to the mice receiving conventional irradiation. Following FLASH irradiation, a maximum weight loss of ∼20% was observed at day 6 with subsequent recovery, while following conventional irradiation, higher weight losses was observed with fewer instances of recovery. Concerning survival, all mice in the conventionally irradiated groups had a 100% mortality in the range of 15.5–18 Gy, while the mice irradiated with FLASH irradiation had a 100% survival in the same range. Conclusion: These results have demonstrated proof of principle that FLASH irradiations have a dramatic impact on the overall survival of mice following GI tract irradiations. If the increase in the therapeutic window can be validated and understood, this would revolutionize the field of radiation oncology and lead to increased cure rates with reduced side effects following treatment, resulting in increased quality of life for cancer survivors. Funding: DoD, Award#:W81XWH-14-1-0014, Weston Havens Foundation, Bio-X (Stanford University), the Office of the Dean of the Medical School, the Office of the Provost (Stanford University), and the Swedish Childhood Cancer Foundation; BL and PM are

  17. TU-H-CAMPUS-TeP2-02: FLASH Irradiation Improves the Therapeutic Index Following GI Tract Irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Schueler, E; Trovati, S; King, G; Lartey, F; Rafat, M; Loo, B; Maxim, P [Stanford University School of Medicine, Palo Alto, California (United States)

    2016-06-15

    Purpose: To investigate and characterize the radiobiological effectiveness of very high dose rate radiotherapy (FLASH) compared to conventional irradiation in an in vivo model. Methods: The gastrointestinal (GI) tract of C57BL/6 mice were irradiated with doses ranging between 10 and 18 Gy using a custom stereotactic jig. A Varian Clinac 21EX was modified to allow dose rates ranging from 0.05 to 240 Gy/s at the position of the mirror. With the gantry at 180 degrees, the jig holding the individual animals was placed above the mirror to take advantage of the reduced source to target distance. Mice were irradiated with 20MeV electrons. Following irradiation, the mice were monitored twice daily for morbidity and daily for weight changes. Results: Mice irradiated with FLASH irradiation had lower weight loss compared to the mice receiving conventional irradiation. Following FLASH irradiation, a maximum weight loss of ∼20% was observed at day 6 with subsequent recovery, while following conventional irradiation, higher weight losses was observed with fewer instances of recovery. Concerning survival, all mice in the conventionally irradiated groups had a 100% mortality in the range of 15.5–18 Gy, while the mice irradiated with FLASH irradiation had a 100% survival in the same range. Conclusion: These results have demonstrated proof of principle that FLASH irradiations have a dramatic impact on the overall survival of mice following GI tract irradiations. If the increase in the therapeutic window can be validated and understood, this would revolutionize the field of radiation oncology and lead to increased cure rates with reduced side effects following treatment, resulting in increased quality of life for cancer survivors. Funding: DoD, Award#:W81XWH-14-1-0014, Weston Havens Foundation, Bio-X (Stanford University), the Office of the Dean of the Medical School, the Office of the Provost (Stanford University), and the Swedish Childhood Cancer Foundation; BL and PM are

  18. São Gião de Nazaré (Portugal. Un tipo original de iglesia

    Directory of Open Access Journals (Sweden)

    Caballero, Luis

    2003-12-01

    Full Text Available The scientific importance of the Portuguese church of São Gião de Nazaré, considered one of the prototypes of 7th century Iberian Visigoth architecture, merited an archaeological analysis of its architecture in addition to the excavation of its cellars and prior to necessary restoration work on the building, which was on the brink of ruin. Readings discovered an original church with a nave with high rooms to the west and east, side rooms, iconostases and freestanding vaulted rectangular apse. The structure scarcely changed until its ruin and subsequent conversion into farm workers’ dwellings in the 18th century. The chronological ascription of the church, presently in doubt due to the problems concerning the architectural group traditionally called Visigoth, cannot be solved through the reading but can be enhanced by this as two different decorative groups are identified, one with reused pieces and the other with new sculptures. This deliberately sculpted decoration is now the chronological indicator to follow in dating the original church: for some, it is clearly Visigoth; for others, Asturian.La importancia científica de la iglesia portuguesa de São Gião de Nazaré, considerada como uno de los prototipos de la arquitectura visigoda peninsular del siglo VII, recomendaba un análisis arqueológico de su arquitectura complementario a la excavación del subsuelo y previo a los necesarios trabajos de restauración del edificio en amenaza de ruina. La lectura descubre una iglesia original de nave central con dos habitaciones altas a Oeste y Este, habitaciones laterales, iconostasis y ábside rectangular exento abovedado. Su estructura apenas varía hasta el momento de ruina y posterior transformación en casa labriega en el siglo XVIII. La adscripción cronológica de la iglesia, puesta en duda actualmente dentro de una problemática que afecta al conjunto de arquitectura tradicionalmente denominada visigoda, no se resuelve con la lectura

  19. Liposome bupivacaine for improvement in economic outcomes and opioid burden in GI surgery: IMPROVE Study pooled analysis

    Directory of Open Access Journals (Sweden)

    Cohen SM

    2014-06-01

    Full Text Available Stephen M Cohen,1 Jon D Vogel,2 Jorge E Marcet,3 Keith A Candiotti4 1Atlanta Colon and Rectal Surgery, PA, Atlanta, GA, USA; 2General Surgery Clinic, University of Colorado, Aurora, CO, USA; 3Department of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL, USA; 4Department of Anesthesiology, University of Miami Leonard Miller School of Medicine, Miami, FL, USA Abstract: Postsurgical pain management remains a significant challenge. Liposome bupivacaine, as part of a multimodal analgesic regimen, has been shown to significantly reduce postsurgical opioid consumption, hospital length of stay (LOS, and hospitalization costs in gastrointestinal (GI surgery, compared with intravenous (IV opioid-based patient-controlled analgesia (PCA. Pooled results from open-label studies comparing a liposome bupivacaine-based multimodal analgesic regimen with IV opioid PCA were analyzed. Patients (n=191 who underwent planned surgery and received study drug (IV opioid PCA, n=105; multimodal analgesia, n=86 were included. Liposome bupivacaine-based multimodal analgesia compared with IV opioid PCA significantly reduced mean (standard deviation [SD] postsurgical opioid consumption (38 [55] mg versus [vs] 96 [85] mg; P<0.0001, postsurgical LOS (median 2.9 vs 4.3 days; P<0.0001, and mean hospitalization costs (US$8,271 vs US$10,726; P=0.0109. The multimodal analgesia group reported significantly fewer patients with opioid-related adverse events (AEs than the IV opioid PCA group (P=0.0027; there were no significant between-group differences in patient satisfaction scores at 30 days. A liposome bupivacaine-based multimodal analgesic regimen was associated with significantly less opioid consumption, opioid-related AEs, and better health economic outcomes compared with an IV opioid PCA-based regimen in patients undergoing GI surgery. Study registration: This pooled analysis is based on data from Phase IV clinical trials registered on the US National

  20. Water-soluble upper GI based on clinical findings is reliable to detect anastomotic leaks after laparoscopic gastric bypass.

    Science.gov (United States)

    Katasani, V G; Leeth, R R; Tishler, D S; Leath, T D; Roy, B P; Canon, C L; Vickers, S M; Clements, R H

    2005-11-01

    Anastomotic leak after laparoscopic Roux-en-Y gastric bypass (LGB) is a major complication that must be recognized and treated early for best results. There is controversy in the literature regarding the reliability of upper GI series (UGI) in diagnosing leaks. LGB was performed in patients meeting NIH criteria for the surgical treatment of morbid obesity. All leaks identified at the time of surgery were repaired with suture and retested. Drains were placed at the surgeon's discretion. Postoperatively, UGI was performed by an experienced radiologist if there was a clinical suspicion of leak. From September 2001 until October 2004, a total of 553 patients (age 40.4 +/- 9.2 years, BMI 48.6 +/- 7.2) underwent LGB at UAB. Seventy-eight per cent (431 of 553) of patients had no clinical evidence suggesting anastomotic leak and were managed expectantly. Twenty-two per cent (122 of 553) of patients met at least one inclusion criteria for leak and underwent UGI. Four of 122 patients (3.2%) had a leak, two from anastomosis and two from the perforation of the stapled end of the Roux limb. No patient returned to the operating room without a positive UGI. High clinical suspicion and selectively performed UGI based on clinical evidence is reliable in detecting leaks.

  1. The utilisation and diagnostic yield of radiological imaging in a specialist functional GI disorder clinic: an 11-year retrospective study

    International Nuclear Information System (INIS)

    Breen, Micheal; O'Neill, Siobhan B.; O'Donovan, Joanne P.; McWilliams, Sebastian; Murphy, Kevin P.; Maher, Michael M.; Desmond, Alan N.; Shanahan, Fergus; Quigley, Eamonn M.

    2014-01-01

    The term functional gastrointestinal disorders (FGID) describes various aggregations of chronic gastrointestinal (GI) symptoms not explained by identifiable organic pathology; accordingly, their diagnosis rests on symptom-based criteria and a process of exclusion. Evidence is lacking on the appropriate use of abdominal imaging studies (AIS) in FGIDs. We investigated the utilisation of AIS (site, modality, diagnostic yield/significance) at a tertiary FGID clinic over an 11-year period. Of 1,621 patients, 507 (31 %; 67.5 % women, mean age 43.9 ± 17.37 years) referred from primary care had 997 AIS (1.7 per patient): ultrasonography (US) 36.1 %, fluoroscopy (FLS) 28.8 %, computed tomography (CT) 19.6 %, plain radiography (PR) 13.5 %, nuclear medicine (NM) 1 %. Of the 997 AIS, 55.6 % (554/997) were normal. Of the AIS with positive findings, 9.9 % (62/625) were deemed 'probably significant' and 14.7 % (92/625) 'significant'. Of the CT and FLS studies, 12.3 % and 13.6 %, respectively, yielded 'significant' abnormalities compared to 2.2 % of the US studies and 2.1 % of the PR studies. CT identified five of seven neoplasms, associated with male sex, increasing age and symptom onset after age 50 years. This study confirmed low use of AIS in tertiary FGID clinics and a high proportion of normal studies. Barium swallow/meal and CT were more likely to identify 'probably significant' or 'significant' findings, including neoplasms. (orig.)

  2. Energy Transition Initiative: Island Energy Snapshot - Federated States of Micronesia; U.S. Department of Energy (DOE), NREL (National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-06-01

    This profile provides a snapshot of the energy landscape of the Federated States of Micronesia, a sovereign nation and U.S.-associated state in the western Pacific Ocean. The Federated States of Micronesia’s electricity rates for residential customers exceed $0.48 U.S. dollars (USD)/per kilowatt-hour (kWh), nearly four times the average U.S. residential rate of $0.13 USD/kWh.

  3. Using Internet Snapshot Surveys to Enhance Our Understanding of the Availability of the Novel Psychoactive Substance 4-Methylaminorex and 4,4′-Dimethylaminorex

    OpenAIRE

    Nizar, Hisham; Dargan, Paul I.; Wood, David M.

    2014-01-01

    4,4′-Dimethylaminorex is a stimulant novel psychoactive substance (NPS) first detected in Europe in November 2012. It is a derivative of 4-methylaminorex, a substance controlled under Schedule 1 of the 1971 United Nations Convention on Psychotropic Substances. There is currently no information on the availability or cost of these substances from Internet suppliers. An Internet snapshot study was undertaken in English using established European Monitoring Centre for Drugs and Drug Addiction (E...

  4. GI og GISc

    DEFF Research Database (Denmark)

    Brande-Lavridsen, Hanne

    Udviklingen inden for kort- og geodataverdenen ligner udviklingen inden for alle andre erhverv, hvor globaliseringen spiller en stor rolle. Her kan man vælge de negative tilgang og se udviklingen som uoverskuelig og foruroligende. Eller man kan vælge en positiv og se udviklingen som udfordrende og...

  5. Gastrointestinal (GI) Bleeding

    Science.gov (United States)

    ... Definition & Facts Symptoms & Causes Diagnosis Treatment Eating, Diet, & Nutrition Clinical Trials Acid Reflux (GER & GERD) in Children & Teens Definition & Facts Symptoms & Causes Diagnosis Treatment Eating, Diet, & Nutrition Clinical Trials Acid Reflux (GER & GERD) in Infants Definition & ...

  6. Upper GI Endoscopy

    Science.gov (United States)

    ... if your vomit is bloody or looks like coffee grounds pain in your abdomen that gets worse bloody or ... Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health. ...

  7. Acute GI obstruction.

    Science.gov (United States)

    Hucl, Tomas

    2013-10-01

    Acute gastrointestinal obstruction occurs when the normal flow of intestinal contents is interrupted. The blockage can occur at any level throughout the gastrointestinal tract. The clinical symptoms depend on the level and extent of obstruction. Various benign and malignant processes can produce acute gastrointestinal obstruction, which often represents a medical emergency because of the potential for bowel ischemia leading to perforation and peritonitis. Early recognition and appropriate treatment are thus essential. The typical clinical symptoms associated with obstruction include nausea, vomiting, dysphagia, abdominal pain and failure to pass bowel movements. Abdominal distention, tympany due to an air-filled stomach and high-pitched bowel sounds suggest the diagnosis. The diagnostic process involves imaging including radiography, ultrasonography, contrast fluoroscopy and computer tomography in less certain cases. In patients with uncomplicated obstruction, management is conservative, including fluid resuscitation, electrolyte replacement, intestinal decompression and bowel rest. In many cases, endoscopy may aid in both the diagnostic process and in therapy. Endoscopy can be used for bowel decompression, dilation of strictures or placement of self-expandable metal stents to restore the luminal flow either as a final treatment or to allow for a delay until elective surgical therapy. When gastrointestinal obstruction results in ischemia, perforation or peritonitis, emergency surgery is required. Copyright © 2013. Published by Elsevier Ltd.

  8. Lower GI Series

    Science.gov (United States)

    ... picture created by using radiation and recorded on film or on a computer. To make the large ... cramps and bloating that may occur for a short time after the procedure • to resume most normal ...

  9. GI Locator Service

    Science.gov (United States)

    ... LIBERIA LIBYA LIECHTENSTEIN LITHUANIA LUXEMBOURG MACAO MADAGASCAR MALAWI MALAYSIA MALDIVES MALI MALTA MARIANA ISLANDS MARSHALL ISLANDS Martinique ... OF KOREA REPUBLIC OF MACEDONIA REUNION ROMANIA RUSSIAN FEDERATION RWANDA SAINT BARTHéLEMY SAINT HELENA SAINT KITTS AND ...

  10. GI Radiographic Tests

    Science.gov (United States)

    ... film as varying degrees of black, white, or gray. Barium Esophagram (Barium Swallow) Barium studies, also called ... ray films are then made and the colon anatomy is visualized. Abnormal findings may include colon cancer, ...

  11. About GI Motility

    Science.gov (United States)

    ... Pseudo-Obstruction Small Bowel Bacterial Overgrowth The Large Intestine (Colon) Constipation Diarrhea Hirschsprung's Disease Irritable Bowel Syndrome (IBS) The Anorectum and Pelvic Floor Fecal Incontinence ...

  12. Learn About GI Motility

    Science.gov (United States)

    ... Pseudo-Obstruction Small Bowel Bacterial Overgrowth The Large Intestine (Colon) Constipation Diarrhea Hirschsprung's Disease Irritable Bowel Syndrome (IBS) The Anorectum and Pelvic Floor Fecal Incontinence ...

  13. Mars Geochemical Instrument (MarGI): An instrument for the analysis of the Martian surface and the search for evidence of life

    Science.gov (United States)

    Kojiro, Daniel R.; Mancinelli, Rocco; Martin, Joe; Holland, Paul M.; Stimac, Robert M.; Kaye, William J.

    2005-01-01

    The Mars Geochemical Instrument, MarGI, was developed to provide a comprehensive analysis of the rocks and surface material on Mars. The instrument combines Differential Thermal Analysis (DTA) with miniature Gas Chromatography-Ion Mobility Spectrometry (GC-IMS) to identify minerals, the presence and state of water, and organic compounds. Miniature pyrolysis ovens are used to both, conduct DTA analysis of soil or crushed rocks samples, and pyrolyze the samples at temperatures up to 1000 degrees C for GC-IMS analysis of the released gases. This combination of analytical processes and techniques, which can characterize the mineralogy of the rocks and soil, and identify and quantify volatiles released during pyrolysis, has applications across a wide range of target sites including comets, planets, asteroids, and moons such as Titan and Europa. The MarGI analytical approach evolved from the Cometary Ice and Dust Experiment (CIDEX) selected to fly on the Comet Rendezvous Asteroid Flyby Mission (CRAF).

  14. The Effect of Laser Irradiation on Shear Bond Strength of GI to Dentin After CPP-ACP Treatment

    Directory of Open Access Journals (Sweden)

    Moezizadeh

    2016-02-01

    Full Text Available Background Dentin sensitivity is one of the most important problems in dentistry. Enamel loss due to root exposure is serious issue and common exposure is one of the reasons for dentin hypersensitivity. There are different methods for solving this problem. One of the most conservative and least expensive methods is use of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP paste. Objectives The aim of this study was to evaluate shear bond strength of GIC to dentin, with or without laser, CPP-ACP paste and polyacrylic acid treatments. Materials and Methods Fifty sound human third molars were bisected in a mesiodistal direction using a diamond disk. Using 400, 600 and 800 grit silicon carbide paper, dentin surfaces were exposed. The teeth were divided into five groups. In groups A, B, D and H, CPP-ACP (GC tooth mousse Itabashi-Ku, Tokyo, Japan was applied for one hour the first day and repeated at the same time of day for a total of five days. In groups B, C, D and E, the specimens were subjected to laser for 10 seconds using Er, Cr: YSGG laser. In groups B, C, H and G, specimens were treated with 10% polyacrylic acid for 20 seconds. A plastic tube containing GI was positioned over the tooth. Samples were loaded in shear bond using a Universal Testing Machine (Zwick/Roell, Germany, at a 0.5 mm/minute crosshead speed. Results Despite the failing of groups A and D, group analysis showed that there were no significant differences between the groups. The predominant type of fracture in all groups was adhesive. Conclusions Application of CPP-ACP, without preconditioning with polyacrylic acid, can decrease shear bond strength. Laser irradiation has no effect on shear bond strength of GIC to dentin in this condition.

  15. Undiagnosed pancreatic exocrine insufficiency and chronic pancreatitis in functional GI disorder patients with diarrhea or abdominal pain.

    Science.gov (United States)

    Talley, Nicholas J; Holtmann, Gerald; Nguyen, Quoc Nam; Gibson, Peter; Bampton, Peter; Veysey, Martin; Wong, James; Philcox, Stephen; Koloski, Natasha; Bunby, Lisa; Jones, Michael

    2017-11-01

    A previous UK study showed that 6.1% of patients with diarrhea-predominant irritable bowel syndrome (IBS-D) had evidence of severe pancreatic exocrine insufficiency (PEI), but these findings need replication. We aimed to identify the prevalence of PEI based on fecal elastase stool testing in consecutive outpatients presenting with chronic unexplained abdominal pain and/or diarrhea and/or IBS-D. Patients aged over 40 years presenting to hospital outpatient clinics from six sites within Australia with unexplained abdominal pain and/or diarrhea for at least 3 months and/or IBS-D were studied. Patients completed validated questionnaires and donated a stool sample in which elastase concentration was measured by ELISA. A concentration of abdominal CT. Two hundred eighteen patients (mean age of 60 years, 29.4% male) were studied. PEI was found in 4.6% (95% CI 2.2-8.3%) (n = 10), with five patients (2.3% (95% CI 0.8-5.3%) having severe PEI. Only male sex and heavy alcohol use were significantly associated with abnormal versus normal pancreatic functioning. Of seven patients who underwent endoscopic ultrasound or CT, two had features indicative of chronic pancreatitis. One in 50 patients with IBS-D or otherwise unexplained abdominal pain or diarrhea have an abnormal fecal elastase, but unexpected pancreatic insufficiency was detected in only a minority of these. This study failed to confirm the high prevalence of PEI among patients with unexplained GI symptoms previously reported. © 2017 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.

  16. Searching for an alternative oral contrast agent for GI tract MR imaging; in vitro phase, initial report

    International Nuclear Information System (INIS)

    Okla, W.; Szeszkowski, W.; Cieszanowski, A.; Golebiowski, M.

    2002-01-01

    MR has been recently considered to be suitable method for detection GI tract pathologies. A few substances (some of a natural origin) seem to act as an efficient oral MR contrast agents. The aim of this study is to find an alternative substance, which can be administrated orally to patients in order to enhance signal intensity (SI). The ideal agent should have a biphase pattern (high SI in T1 and low in T2), and should be nontoxic and cost effective. Phantom experiments were conducted with 1.5 T MR scanner. T1W and T2W sequences were used for initial estimation. Number of different agents such as: water, Gd-DTPA, barium sulfate, green tea, blueberry juice, cranberry juice, blackcurrant juice, and some more were evaluated. Signal intensity was measured by using elliptical region of interest (ROI). MR imaging in one patient with stomach cancer was also performed. In T1W-FFE sequence cranberry juice reached satisfactorily high signal (SI=1760.14). In T2W-TSE sequence this substance reduced signal intensity (SI=23.10) almost to background level. Blueberry juice appear to be the next substance capable to generate high signal (SI=1558.31) in T1W sequence (T1-TSE). MR examination of a patient with stomach adenocarcinoma (using blueberry juice as an oral contrast agent) satisfactorily depicted and delineated tumor mass on both: T1W and T2W images. Cranberry juice and blueberry juice seemed to act effectively as oral contrast agents for gastrointestinal MR imaging. Thus they need further exploration and trials. (author)

  17. UPAYA PENINGKATAN AKTIVITAS DAN PRESTASI BELAJAR PENDIDIKAN AGAMA HINDU MELALUI PENERAPAN COOPERATIVE LEARNING TIPE GROUP INVESTIGATION (GI

    Directory of Open Access Journals (Sweden)

    Ida I Dewa Ayu Ketut Putri

    2016-08-01

    Full Text Available Cooperative learning : group investigation (GI is a learning strategy to determine the student’s development and progress that oriented to class activities and allow students to use a variety of learning resources besides teachers. Thelow learning achievement obtained by students in particular on the subjects of Hinduism is noteworthy. It is caused by several factors, including the intelligence of students, student motivation, interest in learning, study habits, as well as external factors such as student living environment, the infrastructure that supports the learning process inadequate. To see whether the implementation of Cooperative Learning type Group Investigation able to improve student learning outcomes, this study applied the model to the 2nd year student (class F in SMP Negeri 3 Denpasar school year 2011/2012. This study was classifiedas a class action (classroom action reseach which is the subject is the 2nd year student (class F as many as 28 people and the object of research is thestudent’s learning activities. This study used primary data obtained directly from the students by using the technique of testing and observation sheet. The collected data were analyzed descriptively based on the average and standarddeviation that obtained through the results of the evaluation scores at each end of the cycle. The results showed a very significant increase in activity of students from an average score of 2.93 in the first cycle to 4.14 in the second cycle. The average student achievement in the first cycle is 70.64 with classical completeness of 60% increased to 75.54 with classical completeness of 92.9%.

  18. The utilisation and diagnostic yield of radiological imaging in a specialist functional GI disorder clinic: an 11-year retrospective study

    Energy Technology Data Exchange (ETDEWEB)

    Breen, Micheal; O' Neill, Siobhan B.; O' Donovan, Joanne P.; McWilliams, Sebastian [Cork University Hospital, Department of Radiology, Cork (Ireland); Murphy, Kevin P.; Maher, Michael M. [Cork University Hospital, Department of Radiology, Cork (Ireland); University College Cork, Department of Radiology, Cork (Ireland); Desmond, Alan N. [Cork University Hospital, Department of Medicine, Cork (Ireland); Shanahan, Fergus; Quigley, Eamonn M. [Cork University Hospital, Department of Medicine, Cork (Ireland); University College Cork, Alimentary Pharmabiotic Center, Cork (Ireland)

    2014-12-15

    The term functional gastrointestinal disorders (FGID) describes various aggregations of chronic gastrointestinal (GI) symptoms not explained by identifiable organic pathology; accordingly, their diagnosis rests on symptom-based criteria and a process of exclusion. Evidence is lacking on the appropriate use of abdominal imaging studies (AIS) in FGIDs. We investigated the utilisation of AIS (site, modality, diagnostic yield/significance) at a tertiary FGID clinic over an 11-year period. Of 1,621 patients, 507 (31 %; 67.5 % women, mean age 43.9 ± 17.37 years) referred from primary care had 997 AIS (1.7 per patient): ultrasonography (US) 36.1 %, fluoroscopy (FLS) 28.8 %, computed tomography (CT) 19.6 %, plain radiography (PR) 13.5 %, nuclear medicine (NM) 1 %. Of the 997 AIS, 55.6 % (554/997) were normal. Of the AIS with positive findings, 9.9 % (62/625) were deemed 'probably significant' and 14.7 % (92/625) 'significant'. Of the CT and FLS studies, 12.3 % and 13.6 %, respectively, yielded 'significant' abnormalities compared to 2.2 % of the US studies and 2.1 % of the PR studies. CT identified five of seven neoplasms, associated with male sex, increasing age and symptom onset after age 50 years. This study confirmed low use of AIS in tertiary FGID clinics and a high proportion of normal studies. Barium swallow/meal and CT were more likely to identify 'probably significant' or 'significant' findings, including neoplasms. (orig.)

  19. Real-time fluorescence target/background (T/B) ratio calculation in multimodal endoscopy for detecting GI tract cancer

    Science.gov (United States)

    Jiang, Yang; Gong, Yuanzheng; Wang, Thomas D.; Seibel, Eric J.

    2017-02-01

    Multimodal endoscopy, with fluorescence-labeled probes binding to overexpressed molecular targets, is a promising technology to visualize early-stage cancer. T/B ratio is the quantitative analysis used to correlate fluorescence regions to cancer. Currently, T/B ratio calculation is post-processing and does not provide real-time feedback to the endoscopist. To achieve real-time computer assisted diagnosis (CAD), we establish image processing protocols for calculating T/B ratio and locating high-risk fluorescence regions for guiding biopsy and therapy in Barrett's esophagus (BE) patients. Methods: Chan-Vese algorithm, an active contour model, is used to segment high-risk regions in fluorescence videos. A semi-implicit gradient descent method was applied to minimize the energy function of this algorithm and evolve the segmentation. The surrounding background was then identified using morphology operation. The average T/B ratio was computed and regions of interest were highlighted based on user-selected thresholding. Evaluation was conducted on 50 fluorescence videos acquired from clinical video recordings using a custom multimodal endoscope. Results: With a processing speed of 2 fps on a laptop computer, we obtained accurate segmentation of high-risk regions examined by experts. For each case, the clinical user could optimize target boundary by changing the penalty on area inside the contour. Conclusion: Automatic and real-time procedure of calculating T/B ratio and identifying high-risk regions of early esophageal cancer was developed. Future work will increase processing speed to <5 fps, refine the clinical interface, and apply to additional GI cancers and fluorescence peptides.

  20. Uudised : Menukalt Austraaliast. ERSO esitles Tubina CDd. Paul Mägi hindas lauljaid. Klavessiinisari muuseumis. Hingedepäev kontserdisaalis. Uus lauljate võistlus Tartus / Saari Tamm

    Index Scriptorium Estoniae

    Tamm, Saari, 1968-

    1999-01-01

    E.Filh. Kammerkoori Austraalia-turneest, kus anti T. Kaljuste juhatusel 8 kontserti. Soome plaadifirma ALBA poolt välja antud CD-st Tubina 2. ja 5. sümfooniaga. P. Mägi osales 17.-22. okt. Itaalias San Remo V rahvusvahelise ooperilauljate konkursi žüriis. 7. nov. Adamson-Ericu muuseumis toimuvast klavessiinimuusikakontserdist, kontserdisarjast. 2. nov. Estonia kontserdisaalis toimunud tütarlastekoori kontserdist

  1. Cross-cultural adaptation of the Schizophrenia Caregiver Questionnaire (SCQ) and the Caregiver Global Impression (CaGI) Scales in 11 languages.

    Science.gov (United States)

    Rofail, Diana; Acquadro, Catherine; Izquierdo, Cécile; Regnault, Antoine; Zarit, Steven H

    2015-06-09

    The Schizophrenia Caregiver Questionnaire (SCQ) was developed to provide a comprehensive view of caregivers' subjective experiences of the impacts of caring for someone with schizophrenia. The Caregiver Global Impression (CaGI) scales were designed to assess their perception of the severity of the schizophrenia symptoms, of change in schizophrenia symptoms and in the experience of caring since the beginning of the study. The objectives of the study were to translate the SCQ and CaGI scales in 11 languages [French (Canada, France), English (Canada, UK, Australia), German (Germany), Italian (Italy), Spanish (Spain), Dutch (the Netherlands), Finnish (Finland), and Swedish (Sweden)], to present evidence that the translations capture the concepts of the original questionnaires and are well understood by caregivers of patients with schizophrenia in each target country. The different language versions were developed using a standard or adjusted linguistic validation process fully complying with the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) recommended procedures. Interviews were conducted with 55 caregivers of patients with schizophrenia from 10 countries representing the 11 different languages. Participants ranged in age from 28 to 84 years and had 5 to 16 years of education. Women represented 69.1 % (38/55) of the sample. Fourteen out of the 32 items of the SCQ generated difficulties which were mostly of semantic origin (13 items). The translation of the CaGI scales did not raise any major difficulty. Only five out of the 55 caregivers had difficulty understanding the meaning of the translations of "degree" in the expressions "degree of change in experience of caring" and "degree of change in symptoms". Translations of the SCQ and CaGI scales into 11 languages adequately captured the concepts in the original English versions of the questionnaires, thereby demonstrating the conceptual, semantic, and cultural equivalence of each translation.

  2. Evaluation of RIDA®GENE norovirus GI/GII real time RT-PCR using stool specimens collected from children and adults with acute gastroenteritis.

    Science.gov (United States)

    Kanwar, N; Hassan, F; Barclay, L; Langley, C; Vinjé, J; Bryant, P W; George, K St; Mosher, L; Matthews-Greer, J M; Rocha, M A; Beenhouwer, D O; Harrison, C J; Moffatt, M; Shastri, N; Selvarangan, R

    2018-04-10

    Norovirus is the leading cause of epidemic and sporadic acute gastroenteritis (AGE) in the United States. Widespread prevalence necessitates implementation of accurate norovirus detection assays in clinical diagnostic laboratories. To evaluate RIDA ® GENE norovirus GI/GII real-time RT-PCR assay (RGN RT-PCR) using stool samples from patients with sporadic AGE. Patients between 14 days to 101 years of age with symptoms of AGE were enrolled prospectively at four sites across the United States during 2014-2015. Stool specimens were screened for the presence of norovirus RNA by the RGN RT-PCR assay. Results were compared with a reference method that included conventional RT-PCR and sequencing of a partial region of the 5'end of the norovirus ORF2 gene. A total of 259 (36.0%) of 719 specimens tested positive for norovirus by the reference method. The RGN RT-PCR assay detected norovirus in 244 (94%) of these 259 norovirus positive specimens. The sensitivity and specificity (95% confidence interval) of the RGN RT-PCR assay for detecting norovirus genogroup (G) I was 82.8% (63.5-93.5) and 99.1% (98.0-99.6) and for GII was 94.8% (90.8-97.2) and 98.6% (96.9-99.4), respectively. Seven specimens tested positive by the RGN-RT PCR that were negative by the reference method. The fifteen false negative samples were typed as GII.4 Sydney, GII.13, GI.3, GI.5, GI.2, GII.1, and GII.3 in the reference method. The RGN RT-PCR assay had a high sensitivity and specificity for the detection of norovirus in stool specimens from patients with sporadic AGE. Copyright © 2018. Published by Elsevier B.V.

  3. Dianthosaponins G-I, triterpene saponins, an anthranilic acid amide glucoside and a flavonoid glycoside from the aerial parts of Dianthus japonicus and their cytotoxicity.

    Science.gov (United States)

    Kanehira, Yuka; Kawakami, Susumu; Sugimoto, Sachiko; Matsunami, Katsuyoshi; Otsuka, Hideaki

    2016-10-01

    Extensive isolation work on the 1-BuOH-soluble fraction of a MeOH extract of the aerial parts of Dianthus japonicus afforded three further triterpene glycosyl estsers, termed dianthosaponins G-I, an anthranilic acid amide glucoside and a C-glycosyl flavonoid along with one known triterpene saponin. Their structures were elucidated from spectroscopic evidence. The cytotoxicity of the isolated compounds toward A549 cells was evaluated.

  4. The impact of a low glycaemic index (GI diet on simultaneous measurements of blood glucose and fat oxidation: A whole body calorimetric study

    Directory of Open Access Journals (Sweden)

    Bhupinder Kaur

    2016-06-01

    Conclusions: Consumption of LGI meals was capable of attenuating 24-hour blood glucose profiles and decreasing postprandial glucose excursions in healthy Asian males. Additionally, LGI mixed meals were able to promote fat oxidation over carbohydrate oxidation when compared to HGI mixed meals. The consumption of low GI meals may be a strategic approach in improving overall glycaemia and increasing fat oxidation in Asians consuming a high carbohydrate diet.

  5. Staging computed tomography in upper GI malignancy. A survey of the 5 cancer networks covered by the South West Cancer Intelligence Service

    International Nuclear Information System (INIS)

    Callaway, M.P.; Bailey, D.

    2005-01-01

    AIM: To identify the methods and protocols of staging CT scans performed for upper GI malignancy throughout the region covered by the South West Cancer Intelligence Service. MATERIALS AND METHODS: A questionnaire relating to the protocols used in the CT staging of upper GI cancer was circulated to all the Cancer Leads and Clinical Directors of Radiology throughout the network covered by the South West Cancer Intelligence Service (SWCIS). Information about the type of scanner, the provision of protocols and the staging of oesophageal, gastric and pancreatic carcinoma was obtained. RESULTS: Twenty one of the twenty six departments contacted responded (81%). Ninety percent of departments perform staging CT scans to a departmental protocol but these protocols vary throughout the region. Most centres have multislice CT technology and all use intravenous contrast media administered via a pump. All centres us a portal venous phase to exclude liver metastasis in all cancers. Thirty-eight to forty percent of centres use an arterial phase of enhancement when examining the oesophagus and stomach. Sixty one percent of centres use an arterial phase and seventy percent of centres use a pancreatic phase of enhancement in addition to a portal venous phase when staging pancreatic carcinoma. Addition imaging of the chest to identify disseminated disease is often performed, 100% of centres include the chest when staging oesophageal malignancy, 87% include the chest in gastric staging and 51% include this additional scan when staging pancreatic carcinoma. The staging scans were reported in 80% of centres by radiologists with a sub-speciality interest in GI malignancy. CONCLUSION: Whilst nearly all centres perform staging CT scans for upper GI malignancy to a departmental protocol there is much variability in the protocols used throughout the South West region

  6. Noradrenergic mechanisms and high blood pressure maintenance in genetic hypertension: The role of Gi proteins and voltage-dependent calcium channels

    Czech Academy of Sciences Publication Activity Database

    Zicha, Josef; Pintérová, Mária; Líšková, Silvia; Dobešová, Zdenka; Kuneš, Jaroslav

    2007-01-01

    Roč. 29, č. 4 (2007), s. 229-229 ISSN 1064-1963. [International symposium on SHR /12./. 20.10.2006-21.10.2006, Kyoto] R&D Projects: GA MZd(CZ) NR7786 Institutional research plan: CEZ:AV0Z50110509 Keywords : genetic hypertension * noradrenergic mechanisms * Gi proteins * voltage-dependent calcium channels Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery

  7. Analysis of Gastric Adenocarcinoma Data in a Pan-GI Context to Reveal Genes, Pathways, and Interactions that Yield Novel Therapeutic Advantages

    Science.gov (United States)

    2017-09-01

    positive correlations have been found in gastric cancer between TGF-beta pathway activity and the hormone receptor , breast reactive, EMT, immune...associated with resistance 14 6 ge ne s 594 human cancer cell line mRNA profiles bladder , blood, bone, breast, CNS, esophagus, GI tract, lung, kidney, ovary...between the PI3K pathway and lower estro- gen- receptor (ER) levels and activity in ER+ breast cancer . Breast Cancer Res. 12, R40. Dibble, C.C., and

  8. U.S. Geological Survey Community for Data Integration-NWIS Web Services Snapshot Tool for ArcGIS

    Science.gov (United States)

    Holl, Sally

    2011-01-01

    U.S. Geological Survey (USGS) data resources are so vast that many scientists are unaware of data holdings that may be directly relevant to their research. Data are also difficult to access and large corporate databases, such as the National Water Information System (NWIS) that houses hydrologic data for the Nation, are challenging to use without considerable expertise and investment of time. The USGS Community for Data Integration (CDI) was established in 2009 to address data and information management issues affecting the proficiency of earth science research. A CDI workshop convened in 2009 identified common data integration needs of USGS scientists and targeted high value opportunities that might address these needs by leveraging existing projects in USGS science centers, in-kind contributions, and supplemental funding. To implement this strategy, CDI sponsored a software development project in 2010 to facilitate access and use of NWIS data with ArcGIS, a widely used Geographic Information System. The resulting software product, the NWIS Web Services Snapshot Tool for ArcGIS, is presented here.

  9. Chandra Snapshot Spectral Imaging of Comets C/2001 Q4 (NEAT) and C/2002 T7 (LINEAR)

    Science.gov (United States)

    Lisse, Carey

    2003-09-01

    The highly favorable perigee passage of the very bright comets C/2001 Q4 (NEAT) and C/2002 T7 (LINEAR) in late May 2004 provides an opportunity to study cometary x-ray emission in conjunction with the new CHIPS spectroscopic mission. In 10 ksec of on-target time for each comet, ACIS-S will obtain snapshot images of the comets in the heart of the CHIPS 0.05 0.150 keV spectroscopic monitoring period in late-May 2004. The combined observations have the potential of directly detecting for the first time the ultra-soft emission due to Mg, S, Si, and Fe predicted by McCammon et al. (2002) from soft x-ray background measurements and by Kharchenko et al. (2000, 2003) from models of solar wind minor ion charge exchange emission. New work by Wegmann, Dennerl, and Lisse (2004) allows a determination of the neutral gas production rate from the spatial scale of the emission, and an independent determination of the solar wind minor ion flux density using the x-ray surface brightness.

  10. Developing the Regulatory Utility of the Exposome: Mapping Exposures for Risk Assessment through Lifestage Exposome Snapshots (LEnS).

    Science.gov (United States)

    Shaffer, Rachel M; Smith, Marissa N; Faustman, Elaine M

    2017-08-07

    Exposome-related efforts aim to document the totality of human exposures across the lifecourse. This field has advanced rapidly in recent years but lacks practical application to risk assessment, particularly for children's health. Our objective was to apply the exposome to children's health risk assessment by introducing the concept of Lifestage Exposome Snapshots (LEnS). Case studies are presented to illustrate the value of the framework. The LEnS framework encourages organization of exposome studies based on windows of susceptibility for particular target organ systems. Such analyses will provide information regarding cumulative impacts during specific critical periods of the life course. A logical extension of this framework is that regulatory standards should analyze exposure information by target organ, rather than for a single chemical only or multiple chemicals grouped solely by mechanism of action. The LEnS concept is a practical refinement to the exposome that accounts for total exposures during particular windows of susceptibility in target organ systems. Application of the LEnS framework in risk assessment and regulation will improve protection of children's health by enhancing protection of sensitive developing organ systems that are critical for lifelong health and well-being. https://doi.org/10.1289/EHP1250.

  11. Comparative genomic analysis of 45 type strains of the genus Bifidobacterium: a snapshot of its genetic diversity and evolution.

    Directory of Open Access Journals (Sweden)

    Zhihong Sun

    Full Text Available Bifidobacteria are well known for their human health-promoting effects and are therefore widely applied in the food industry. Members of the Bifidobacterium genus were first identified from the human gastrointestinal tract and were then found to be widely distributed across various ecological niches. Although the genetic diversity of Bifidobacterium has been determined based on several marker genes or a few genomes, the global diversity and evolution scenario for the entire genus remain unresolved. The present study comparatively analyzed the genomes of 45 type strains. We built a robust genealogy for Bifidobacterium based on 402 core genes and defined its root according to the phylogeny of the tree of bacteria. Our results support that all human isolates are of younger lineages, and although species isolated from bees dominate the more ancient lineages, the bee was not necessarily the original host for bifidobacteria. Moreover, the species isolated from different hosts are enriched with specific gene sets, suggesting host-specific adaptation. Notably, bee-specific genes are strongly associated with respiratory metabolism and are potential in helping those bacteria adapt to the oxygen-rich gut environment in bees. This study provides a snapshot of the genetic diversity and evolution of Bifidobacterium, paving the way for future studies on the taxonomy and functional genomics of the genus.

  12. Whole-Genome Sequencing for Routine Pathogen Surveillance in Public Health: a Population Snapshot of Invasive Staphylococcus aureus in Europe

    Directory of Open Access Journals (Sweden)

    David M. Aanensen

    2016-05-01

    Full Text Available The implementation of routine whole-genome sequencing (WGS promises to transform our ability to monitor the emergence and spread of bacterial pathogens. Here we combined WGS data from 308 invasive Staphylococcus aureus isolates corresponding to a pan-European population snapshot, with epidemiological and resistance data. Geospatial visualization of the data is made possible by a generic software tool designed for public health purposes that is available at the project URL (http://www.microreact.org/project/EkUvg9uY?tt=rc. Our analysis demonstrates that high-risk clones can be identified on the basis of population level properties such as clonal relatedness, abundance, and spatial structuring and by inferring virulence and resistance properties on the basis of gene content. We also show that in silico predictions of antibiotic resistance profiles are at least as reliable as phenotypic testing. We argue that this work provides a comprehensive road map illustrating the three vital components for future molecular epidemiological surveillance: (i large-scale structured surveys, (ii WGS, and (iii community-oriented database infrastructure and analysis tools.

  13. International Survey of Peer Leadership (ISPL: An Emerging Snapshot of the Status of Peer Leadership in South Africa

    Directory of Open Access Journals (Sweden)

    Frade Nelia

    2017-12-01

    Full Text Available The power and importance of peer influence in educational settings has been well documented (Cuseo, 2010; Ender & Kay, 2001; Keup, 2010. In South Africa, research supports international trends that student involvement in peer-led activities contributes to student success and ultimate throughput (Layton & McKenna, 2015; Loots, 2009; Underhill & McDonald, 2010. A plethora of research exists attesting to the benefits for students who are the recipients of peer-led activities. In South Africa, however, knowledge gaps exist pertaining to a national perspective on the experiences and, to some extent, on the benefits of peer leadership activities for peer leaders themselves. The purpose of this study is to provide an initial national snapshot of the development and experiences of peer leaders at six South African institutions of higher education, using the International Survey of Peer Leaders (ISPL. The research design adopted was a non-probability purposive sampling technique, with a sample size of N=466. Data were analysed using descriptive analyses. Findings validate previous findings and provide a more comprehensive picture of the types of peer leadership positions held, the training and support peer leaders receive, levels of engagement, and the benefits of being involved in peer-led activities.

  14. Snapshot hyperspectral imaging to measure oxygen saturation in the retina using fiber bundle and multi-slit spectrometer

    Science.gov (United States)

    Khoobehi, Bahram; Khoobehi, Aurash; Fournier, Paul

    2012-03-01

    We have developed a snapshot fiber bundle technique that circumvents the issue of saccades of the non-immobilized eye. In this technology, 458 individual fibers are assembled in a two-dimensional array where each fiber represents a portion of the image. These fibers are redistributed into two separate one-dimensional fiber rows interfaced into a two-slit spectrometer. The light from each fiber is decomposed into its spectral components by the spectrometer. Using this innovative technology, we have been able to detect the whole spectrum of hemoglobin using the single light exposure capabilities of a fundus camera. The hemoglobin signature of the retinal arteries, veins, and retina tissue can be recorded. The final result is a complete, 3-dimensional representation of the spectral and spatial information from a single exposure of the patient. By adjusting the field of view on the imaging portion of the fundus camera, the fiber optic cable may encompass a larger area. However, this causes a decrease in spatial resolution, so we increased the area of the fiber array by increasing the number of the fibers from 458 to 648, increased the size of each individual fiber from 10 μm to 20 &μm, and increased the number of slits to four.

  15. Online Social Snapshots of a Generic Facebook Session Based on Digital Insight Data for a Secure Future IT Environment

    Directory of Open Access Journals (Sweden)

    Hai-Cheng Chu

    2015-05-01

    Full Text Available Physical memory acquisition has been an import facet for digital forensics (DF specialists due to its volatile characteristics. Nowadays, thousands of millions of global participants utilize online social networking (OSN mechanisms to expand their social lives, ranging from business-oriented purposes to leisure motivations. Facebook (FB is one of the most dominant social networking sites (SNS available today. Unfortunately, it has been a major avenue for cybercriminals to commit illegal activities. Therefore, the digital traces of previous sessions of an FB user play an essential role as the first step for DF experts to pursue the disclosure of the identity of the suspect who was exploiting FB. In this research work, we provide a systematic methodology to reveal a previous session of an FB identity, as well as his/her partial social circle via collecting, analyzing, preserving and presenting the associated digital traces to obtain the online social snapshots of a specific FB user who was utilizing a computing device with Internet Explorer (IE 10 without turning off the power of the gadget. This novel approach can be a paradigm for how DF specialists ponder the crime scene to conduct the first response in order to avoid the permanent loss of the precious digital evidence in previous FB sessions. The hash values of the image files of the random access memory (RAM of the computing device have proven to be identical before and after forensics operations, which could be probative evidence in a court of law.

  16. Snapshot polarization-sensitive plug-in optical module for a Fourier-domain optical coherence tomography system

    Science.gov (United States)

    Marques, Manuel J.; Rivet, Sylvain; Bradu, Adrian; Podoleanu, Adrian

    2018-02-01

    In this communication, we present a proof-of-concept polarization-sensitive Optical Coherence Tomography (PS-OCT) which can be used to characterize the retardance and the axis orientation of a linear birefringent sample. This module configuration is an improvement from our previous work1, 2 since it encodes the two polarization channels on the optical path difference, effectively carrying out the polarization measurements simultaneously (snapshot measurement), whilst retaining all the advantages (namely the insensitivity to environmental parameters when using SM fibers) of these two previous configurations. Further progress consists in employing Master Slave OCT technology,3 which is used to automatically compensate for the dispersion mismatch introduced by the elements in the module. This is essential given the encoding of the polarization states on two different optical path lengths, each of them having dissimilar dispersive properties. By utilizing this method instead of the commonly used re-linearization and numerical dispersion compensation methods an improvement in terms of the calculation time required can be achieved.

  17. Discrepancies between upper GI symptoms described by those who have them and their identification by conventional medical terminology: a survey of sufferers in four countries.

    Science.gov (United States)

    Heading, Robert C; Thomas, Edward C M; Sandy, Phil; Smith, Gary; Fass, Ronnie; Hungin, Pali S

    2016-04-01

    The objective of this study was to develop a self-administered questionnaire for upper gastrointestinal (GI) symptoms using lay vocabulary uninfluenced by established medical terminology or concepts and to conduct a survey of symptom occurrence among sufferers in four countries. The questionnaire was designed by integrating information gained from the vocabulary used by 38 upper GI symptom sufferers. There was no medical input to its development. The questionnaire was then used, after appropriate translation, in Brazil, Russia, the UK and the USA. Details of 10 659 symptom episodes were obtained from 2665 individuals. Nine symptoms described in lay vocabulary were identified during questionnaire development. Of these, one corresponded to regurgitation, whereas two that were distinguished by survey participants might both be interpreted as heartburn. One chest symptom for which a corresponding medical term was uncertain occurred in ∼30% of the respondents. Five different 'stomach' or abdominal symptoms were identified. The predominant symptom and the pattern of concurrent symptoms often varied from one symptom episode to another. Use of the terms 'heartburn', 'reflux', 'indigestion' and 'burning stomach' to describe symptoms varied between countries. Some common upper GI symptoms described by those who suffer them have no clear counterpart in conventional medical terminology. Inadequacy of the conventional terminology in this respect deserves attention, first, to characterize it fully, and thereafter to construct enquiry that delivers more precise symptom identification. Our results suggest that improvement may require the use of vocabulary of individuals suffering the symptoms without imposing conformity with established symptom concepts.

  18. Answer and discussion paediatric neuroimaging quiz case

    African Journals Online (AJOL)

    2016-06-30

    Jun 30, 2016 ... How to cite this article: ... Figures 1, 2, 3, 4, 5 and 6 are the selected MR images. ... We were fortunate to obtain a good quality MRI study under ... is also noted at the postero-superior right parietal lobe in the angular gyrus.

  19. Nicotine Withdrawal; Measure Your Symptoms (Quiz)

    Science.gov (United States)

    ... Create My Quit Plan How to Quit Smokefree Smartphone Apps Smokefree Texting Programs Get Extra Help Quit ... weight gain * None Slight Mild Moderate Severe Insomnia, sleep problems, awakening at night * None Slight Mild Moderate ...

  20. Web-based Homework and Quiz Systems

    Science.gov (United States)

    Pritchard, David

    2005-05-01

    Mastering Physics is a Socratic tutor designed to help students learn introductory physics. The tutor poses problems and then comments specifically on about 1/2 of all wrong answers, even though most responses demanded are analytic expressions. Students can request hints (some of which are sub-problems), and work through the list of hint titles at random. In a typical problem there are 10 round trip interactions between tutor and student, raising the percentage of students who get the answer from ˜60% on the first try to over 90% after tutoring. This is Mastery Learning where student time and effort are increased to achieve learning rather than the grade decreased to indicate that the learning is incomplete. Mastering Physics is also a homework administration system that aids the instructor in preparing an assignment by indicating (in the problem library) the difficulty and duration of each problem and of the overall assignment. At MIT doing Mastering Physics has been shown to correlate much better than written homework or going to recitation with scoring better on the final exam in May than that student did on the final in December (which is why the student was repeating the course in the spring). At Arizona State, Mastering Physics increased the class' normalized gain on the Force Concept Inventory from 21% to 40% the year it was introduced.

  1. Quiz gaming competitions for undergraduate medical students ...

    African Journals Online (AJOL)

    Arun Kumar Agnihotri

    2014-08-13

    Aug 13, 2014 ... balance of education and entertainment that quizmasters should aim for. .... a game; popular themes, music and audience ... demographic data, an opinion segment for ticking, and ..... provided that the answers linked back.

  2. A snapshot of soil water composition as an indicator of contrasted redox environments in a hedged farmland plot.

    Science.gov (United States)

    Albéric, Patrick; Vennink, Aurélie; Cornu, Sophie; Bourennane, Hocine; Bruand, Ary

    2009-10-15

    While soil water composition has long been recognised as being related to soil type (characteristics of the horizons), the influence of structures resulting from agricultural activities (hedges, ditches, wheel ruts, etc) is still under discussion. This work was undertaken to show that a snapshot of spatial variability of the geochemical characteristics of soil water at the scale of a plot can improve our understanding of soil geochemistry in a farmland setting. We selected a 3 hectare hedged plot located on a hillside, limited by a stream and used as pasture where soils have developed in weathered gneiss. The water depth, electrical conductivity, major ions, temperature, pH, dissolved organic carbon (DOC) content, dissolved oxygen content, fluorescence, alkalinity, Fe(2+), Mn(2+), NO(2)(-), Fe(III) and F(-) contents were measured in 62 auger holes randomly drilled on the site. Four sectors were identified in order to describe the distribution of the main geochemical parameters. Electrical conductivity and some major ions, especially sulphate, had larger concentrations near hedges where oxic conditions prevailed. These features were attributed to the impact of the linear anthropogenic network on the circulation of subsurface soil waters and evapo-transpiration and represent sector I. Dissolved Mn was an indicator of well channelled runoff subsurfaces facilitating the circulation of more highly reducing water (sector III), while DOC probably marked areas drained less well, with a prolonged contact time between soil solutions and organic topsoil horizons (sector II). The presence of dissolved Mn and Fe(II) indicates bottomland anoxic conditions (sector IV). It is concluded that a survey of the chemical composition of soil water may be a direct approach to show the influence of permanent structures on current soil properties and dynamics.

  3. Online test purchased new psychoactive substances in 5 different European countries: A snapshot study of chemical composition and price.

    Science.gov (United States)

    Brunt, Tibor Markus; Atkinson, Amanda Marie; Nefau, Thomas; Martinez, Magali; Lahaie, Emmanuel; Malzcewski, Artur; Pazitny, Martin; Belackova, Vendula; Brandt, Simon D

    2017-06-01

    New psychoactive substances (NPS) are on offer worldwide online, in order to shed light on the purity and price of these substances in the European Union, a research collaboration was set up involving France, United Kingdom (UK), the Netherlands, Czech Republic and Poland. Per country, around 10 different NPS were test purchased from different webshops. Then, chemical analysis of NPS was done with according reference standards to identify and quantify the contents. In contrast to what is generally advertised on the webshops (>99%), purity varied considerably per test purchased NPS. Several NPS were mislabelled, some containing chemical analogues (e.g. 25B/C-NBOMe instead of 25I-NBOMe, pentedrone instead of 3,4-DMMC). But in some cases NPS differed substantially from what was advertised (e.g. pentedrone instead of AMT or 3-FMC instead of 5-MeO-DALT). Per gram, purity-adjusted prices of cathinones differed substantially between three countries of test purchase, with Poland being the least expensive. Synthetic cannabinoids were relatively the most expensive in the Czech Republic and least expensive in the UK. The current findings provides a snapshot of the price and chemical contents of NPS products purchased by different countries and in different webshops. There is a potential danger of mislabelling of NPS. The great variety in price and purity of the delivered products might be the result of the market dynamics of supply and demand and the role of law enforcement in different European countries. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. EurEAs_Gplex--A new SNaPshot assay for continental population discrimination and gender identification.

    Science.gov (United States)

    Daca-Roszak, P; Pfeifer, A; Żebracka-Gala, J; Jarząb, B; Witt, M; Ziętkiewicz, E

    2016-01-01

    Assays that allow analysis of the biogeographic origin of biological samples in a standard forensic laboratory have to target a small number of highly differentiating markers. Such markers should be easy to multiplex and the assay must perform well in the degraded and scarce biological material. SNPs localized in the genome regions, which in the past were subjected to differential selective pressure in various populations, are the most widely used markers in the studies of biogeographic affiliation. SNPs reflecting biogeographic differences not related to any phenotypic traits are not sufficiently explored. The goal of our study was to identify a small set of SNPs not related to any known pigmentation/phenotype-specific genes, which would allow efficient discrimination between populations of Europe and East Asia. The selection of SNPs was based on the comparative analysis of representative European and Chinese/Japanese samples (B-lymphocyte cell lines), genotyped using the Infinium HumanOmniExpressExome microarray (Illumina). The classifier, consisting of 24 unlinked SNPs (24-SNP classifier), was selected. The performance of a 14-SNP subset of this classifier (14-SNP subclassifier) was tested using genotype data from several populations. The 14-SNP subclassifier differentiated East Asians, Europeans and Africans with ∼100% accuracy; Palestinians, representative of the Middle East, clustered with Europeans, while Amerindians and Pakistani were placed between East Asian and European populations. Based on these results, we have developed a SNaPshot assay (EurEAs_Gplex) for genotyping SNPs from the 14-SNP subclassifier, combined with an additional marker for gender identification. Forensic utility of the EurEAs_Gplex was verified using degraded and low quantity DNA samples. The performance of the EurEAs_Gplex was satisfactory when using degraded DNA; tests using low quantity DNA samples revealed a previously not described source of genotyping errors, potentially

  5. Randomized Controlled Trial Investigating the Effects of a Low-Glycemic Index Diet on Pregnancy Outcomes in Women at High Risk of Gestational Diabetes Mellitus: The GI Baby 3 Study.

    Science.gov (United States)

    Markovic, Tania P; Muirhead, Ros; Overs, Shannon; Ross, Glynis P; Louie, Jimmy Chun Yu; Kizirian, Nathalie; Denyer, Gareth; Petocz, Peter; Hyett, Jon; Brand-Miller, Jennie C

    2016-01-01

    Dietary interventions can improve pregnancy outcomes in women with gestational diabetes mellitus (GDM). We compared the effect of a low-glycemic index (GI) versus a conventional high-fiber (HF) diet on pregnancy outcomes, birth weight z score, and maternal metabolic profile in women at high risk of GDM. One hundred thirty-nine women [mean (SD) age 34.7 (0.4) years and prepregnancy BMI 25.2 (0.5) kg/m(2)] were randomly assigned to a low-GI (LGI) diet (n = 72; target GI ∼50) or a high-fiber, moderate-GI (HF) diet (n = 67; target GI ∼60) at 14-20 weeks' gestation. Diet was assessed by 3-day food records and infant body composition by air-displacement plethysmography, and pregnancy outcomes were assessed from medical records. The LGI group achieved a lower GI than the HF group [mean (SD) 50 (5) vs. 58 (5); P diet and a healthy diet produce similar pregnancy outcomes. © 2016 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

  6. Geographic Inventory Framework (GiF) for estimating N2O and CH4 emissions from agriculture in the province of Alberta, Canada

    Science.gov (United States)

    Dimitrov, D. D.; Wang, J.

    2016-12-01

    A Geographic Information Framework (GiF) has been created to estimate and map agricultural N2O and CH4 emissions of the province of Alberta, Canada. The GiF consists of a modelling component, a GIS component, and application software to communicate between the model, database and census data. For compatibility, GiF follows the IPCC Tier 1 method and contains census data for animal populations, crop areas, and farms for the main IPCC animal and plant types (dairy cows, cattle cows, pigs, sheep, poultry, other animals, grasses, legumes, other crops), and estimated N2O and CH4 emissions from manure management, enteric fermentation, direct soil emissions (with applied manure, synthetic fertilizer, crop residue degradation, biological fixation) and indirect soil emissions (with atmospheric deposition and leaching). Methane emissions from enteric fermentation (609.24 Gg) prevailed over those from manure (44.99 Gg), and nitrous oxide emission from manure (22.01 Gg) prevailed over those from soil (17.73 Gg), with cattle cows emitting most N2O and CH4, followed by plant N2O emissions, and pigs and dairy cows CH4 emissions. The GIS maps showed discernible pattern of N2O and CH4 emissions increasing from North and West to the central Alberta and then slightly declining to South and East, which could be useful to address various mitigation strategies. The framework allows easy replacement of Tier 1 emission factors by Tire 2 or 3 ones from process-based models. Future applying of the latter will allow accounting for CO2 source/sink strength of agricultural ecosystems, hence their complete GHG balance affected by soil, water, and climate.

  7. The impact of a low glycaemic index (GI) diet on simultaneous measurements of blood glucose and fat oxidation: A whole body calorimetric study.

    Science.gov (United States)

    Kaur, Bhupinder; Quek Yu Chin, Rina; Camps, Stefan; Henry, Christiani Jeyakumar

    2016-06-01

    Low glycaemic index (GI) foods are known to minimize large fluctuations in blood glucose levels and have been suggested to increase fat oxidation. The objective of this study was to simultaneously investigate glucose excursion and substrate oxidation in a whole body calorimetre when Chinese male subjects were provided a low or high GI meal. In a randomized, controlled crossover non blind design, 12 healthy Chinese male adults (BMI 21.8 ± 1.3 kgm -2 ) attended two sessions consisting of either four low or high glycaemic meals (LGI vs HGI). Breakfast, lunch and snack were consumed in a whole body calorimetre while dinner was consumed at home. Daily changes in glycaemic response (GR) and postprandial GR responses were measured using a continuous glucose monitoring system. The GR was further calculated to obtain the incremental area under the curve (iAUC) for glucose concentrations. Glycaemic variability was calculated as mean amplitude of glycaemic excursion (MAGE). Substrate oxidation was calculated by measuring respiratory quotient and urine nitrogen excretion. After LGI meals in the whole body calorimetre, iAUC for glucose (P = 0.008) was lower compared to the HGI session. The HGI treatment produced a significantly greater MAGE than the LGI treatment over the 24 hour period (P fat oxidation and lower carbohydrate oxidation were observed following breakfast and lunch when comparing LGI to HGI (P fat oxidation over carbohydrate oxidation when compared to HGI mixed meals. The consumption of low GI meals may be a strategic approach in improving overall glycaemia and increasing fat oxidation in Asians consuming a high carbohydrate diet.

  8. Using internet snapshot surveys to enhance our understanding of the availability of the novel psychoactive substance 4-methylaminorex and 4,4'-dimethylaminorex.

    Science.gov (United States)

    Nizar, Hisham; Dargan, Paul I; Wood, David M

    2015-03-01

    4,4'-Dimethylaminorex is a stimulant novel psychoactive substance (NPS) first detected in Europe in November 2012. It is a derivative of 4-methylaminorex, a substance controlled under Schedule 1 of the 1971 United Nations Convention on Psychotropic Substances. There is currently no information on the availability or cost of these substances from Internet suppliers. An Internet snapshot study was undertaken in English using established European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) methodology to determine the availability of 4-methylaminorex and 4,4'-dimethylaminorex in April 2014. Twenty Internet sites selling 4-methylaminorex were identified, 18 selling in US dollars and two in GB Pound Sterling. Fourteen (70 %) Internet sites had a minimum purchase amount of ≥10 g (compared to user doses of 10-25 mg). For the 18 suppliers selling in US$, 9 quoted a fixed price per gram irrespective of the amount ordered and 11 had a reducing price per gram with increasing purchase quantity (US$30.8 ± 34.2/g for 1 g purchase to US$15.2 ± 20.3/g for 1 kg purchase). Only one Internet site selling 4,4'-dimethylaminorex was identified, selling in Euros. The minimum purchase quantity was 500 mg. The price per gram reduced from 36.08/g for a 500 mg purchase to 2.20/g for a 100 g purchase. This Internet snapshot demonstrated that there was a greater availability from Internet suppliers of products advertised as 4-methylaminorex than 4,4'-dimethylaminorex, despite the 4-methylaminorex being an internationally controlled substance. Whilst this may reflect misunderstanding by suppliers, it has the potential to put those purchasing at risk of contravening border control and/or local law enforcement legislation. The use of methodology such as Internet snapshot surveys is of increasing interest to clinical/medical toxicologists in their understanding of the supply, availability and cost of novel psychoactive substances.

  9. Impact of 68Ga-DOTA-Peptide PET/CT on the Management of Gastrointestinal Neuroendocrine Tumour (GI-NET): Malaysian National Referral Centre Experience.

    Science.gov (United States)

    Tan, Teik Hin; Boey, Ching Yeen; Lee, Boon Nang

    2018-04-01

    The National Cancer Institute is the only referral centre in Malaysia that provides 68 Ga-DOTA-peptide imaging. The purpose of this study is to determine the impact of 68 Ga-DOTA-peptide PET/CT on the management of gastrointestinal neuroendocrine tumours (GI-NET). A cross-sectional study was performed to review the impact of 68 Ga-DOTA-peptide ( 68 Ga-DOTATATE or 68 Ga-DOTATOC) PET/CT on patients with biopsy-proven GI-NET between January 2011 and December 2015. Suspected NET was excluded. Demographic data, tumoral characteristics, change of disease stage, pre-PET intended management and post-PET management were evaluated. Over a 5-year period, 82 studies of 68 Ga-DOTA-peptide PET/CT were performed on 44 GI-NET patients. The most common primary site was the rectum (50.0%) followed by the small bowel, stomach and colon. Using WHO 2010 grading, 40.9% of patients had low-grade (G1) tumour, 22.7% intermediate (G2) and 4.5% high (G3). Of ten patients scheduled for pre-operative staging, 68 Ga-DOTA-peptide PET/CT only led to therapeutic change in three patients. Furthermore, false-negative results of 68 Ga-DOTA-peptide PET/CT were reported in one patient after surgical confirmation. However, therapeutic changes were seen in 20/36 patients (55.6%) scheduled for post-surgical restaging or assessment of somatostatin analogue (SSA) eligibility. When 68 Ga-DOTA-peptide PET/CT was used for monitoring disease progress during systemic treatment (sandostatin, chemotherapy, everolimus and PRRT) in metastatic disease, impact on management modification was seen in 19/36 patients (52.8%), of which 84.2% had inter-modality change (switch to everolimus, chemotherapy or PRRT) and 15.8% had intra-modality change (increased SSA dosage). 68 Ga-DOTA-peptide PET/CT has a significant impact on management decisions in GI-NET patients as it can provide additional information on occult metastasis/equivocal lesions and supply the clinician an opportunity to select patients for targeted therapy.

  10. Snapshot Mueller matrix polarimetry by wavelength polarization coding and application to the study of switching dynamics in a ferroelectric liquid crystal cell.

    Directory of Open Access Journals (Sweden)

    Le Jeune B.

    2010-06-01

    Full Text Available This paper describes a snapshot Mueller matrix polarimeter by wavelength polarization coding. This device is aimed at encoding polarization states in the spectral domain through use of a broadband source and high-order retarders. This allows one to measure a full Mueller matrix from a single spectrum whose acquisition time only depends on the detection system aperture. The theoretical fundamentals of this technique are developed prior to validation by experiments. The setup calibration is described as well as optimization and stabilization procedures. Then, it is used to study, by time-resolved Mueller matrix polarimetry, the switching dynamics in a ferroelectric liquid crystal cell.

  11. Development and characterization of a snapshot Mueller matrix polarimeter for the determination of cervical cancer risk in the low resource setting

    Science.gov (United States)

    Ramella-Roman, Jessica C.; Gonzalez, Mariacarla; Chue-Sang, Joseph; Montejo, Karla; Krup, Karl; Srinivas, Vijaya; DeHoog, Edward; Madhivanan, Purnima

    2018-04-01

    Mueller Matrix polarimetry can provide useful information about the function and structure of the extracellular matrix. Mueller Matrix systems are sophisticated and costly optical tools that have been used primarily in the laboratory or in hospital settings. Here we introduce a low-cost snapshot Mueller Matrix polarimeter that that does not require external power, has no moving parts, and can acquire a full Mueller Matrix in less than 50 milliseconds. We utilized this technology in the study of cervical cancer in Mysore India, yet the system could be translated in multiple diagnostic applications.

  12. Structural snapshots along the reaction pathway of Yersinia pestis RipA, a putative butyryl-CoA transferase

    Energy Technology Data Exchange (ETDEWEB)

    Torres, Rodrigo; Lan, Benson; Latif, Yama; Chim, Nicholas [UC Irvine, 2212 Natural Sciences I, Irvine, CA 92697 (United States); Goulding, Celia W., E-mail: celia.goulding@uci.edu [UC Irvine, 2212 Natural Sciences I, Irvine, CA 92697 (United States); UC Irvine, 2302 Natural Sciences I, Irvine, CA 92697 (United States)

    2014-04-01

    The crystal structures of Y. pestis RipA mutants were determined to provide insights into the CoA transferase reaction pathway. Yersinia pestis, the causative agent of bubonic plague, is able to survive in both extracellular and intracellular environments within the human host, although its intracellular survival within macrophages is poorly understood. A novel Y. pestis three-gene rip (required for intracellular proliferation) operon, and in particular ripA, has been shown to be essential for survival and replication in interferon γ-induced macrophages. RipA was previously characterized as a putative butyryl-CoA transferase proposed to yield butyrate, a known anti-inflammatory shown to lower macrophage-produced NO levels. RipA belongs to the family I CoA transferases, which share structural homology, a conserved catalytic glutamate which forms a covalent CoA-thioester intermediate and a flexible loop adjacent to the active site known as the G(V/I)G loop. Here, functional and structural analyses of several RipA mutants are presented in an effort to dissect the CoA transferase mechanism of RipA. In particular, E61V, M31G and F60M RipA mutants show increased butyryl-CoA transferase activities when compared with wild-type RipA. Furthermore, the X-ray crystal structures of E61V, M31G and F60M RipA mutants, when compared with the wild-type RipA structure, reveal important conformational changes orchestrated by a conserved acyl-group binding-pocket phenylalanine, Phe85, and the G(V/I)G loop. Binary structures of M31G RipA and F60M RipA with two distinct CoA substrate conformations are also presented. Taken together, these data provide CoA transferase reaction snapshots of an open apo RipA, a closed glutamyl-anhydride intermediate and an open CoA-thioester intermediate. Furthermore, biochemical analyses support essential roles for both the catalytic glutamate and the flexible G(V/I)G loop along the reaction pathway, although further research is required to fully

  13. The use of paediatric artemisinin combinations in sub-Saharan Africa: a snapshot questionnaire survey of health care personnel

    Directory of Open Access Journals (Sweden)

    Agnandji Selidji T

    2011-12-01

    Full Text Available Abstract Background Paediatric drug formulations for artemisinin combination therapy (P-ACT have been developed over the past few years and have been shown to improve the therapeutic management of young children with uncomplicated falciparum malaria. This process was however not equally paralleled by a timely adoption of P-ACT in national and international treatment recommendations. National malaria programmes in sub-Saharan Africa have not yet widely embraced this new therapeutic tool. To which extent P-ACT is used in the field in sub-Saharan Africa is not known to date. Methods This snapshot questionnaire survey aimed to provide an overview on the current routine practices for the availability and use of P-ACT as anti-malarial treatment for young children in sub-Saharan Africa. Health care personnel in seven countries in West-, Central, and East-Africa were invited to answer a structured questionnaire assessing use and availability of P-ACT. Results A total of 71 respondents including doctors, nurses and pharmacy personnel responsible for the anti-malarial treatment of young children were interviewed. P-ACT was used by 83% (95% confidence interval: 73-90%; n = 59 as first-line treatment for young children. Use of 15 different P-ACT products was reported among which only two have received WHO prequalification status and approval by a stringent registration authority. Use of a specific P-ACT product was not linked to consumer prices or availability of supporting clinical trial data, but may depend more on the marketing capacity of the manufacturer. Major differences in frequency and dosing of anti-malarial regimens with identical anti-malarial compounds and the marketing of loose combinations were recorded. Conclusion Paediatric ACT is widely used for the treatment of uncomplicated malaria in young children. However, the majority of P-ACT formulations in use do not meet highest international quality standards evoking concerns for patients

  14. Structural snapshots along the reaction pathway of Yersinia pestis RipA, a putative butyryl-CoA transferase

    International Nuclear Information System (INIS)

    Torres, Rodrigo; Lan, Benson; Latif, Yama; Chim, Nicholas; Goulding, Celia W.

    2014-01-01

    The crystal structures of Y. pestis RipA mutants were determined to provide insights into the CoA transferase reaction pathway. Yersinia pestis, the causative agent of bubonic plague, is able to survive in both extracellular and intracellular environments within the human host, although its intracellular survival within macrophages is poorly understood. A novel Y. pestis three-gene rip (required for intracellular proliferation) operon, and in particular ripA, has been shown to be essential for survival and replication in interferon γ-induced macrophages. RipA was previously characterized as a putative butyryl-CoA transferase proposed to yield butyrate, a known anti-inflammatory shown to lower macrophage-produced NO levels. RipA belongs to the family I CoA transferases, which share structural homology, a conserved catalytic glutamate which forms a covalent CoA-thioester intermediate and a flexible loop adjacent to the active site known as the G(V/I)G loop. Here, functional and structural analyses of several RipA mutants are presented in an effort to dissect the CoA transferase mechanism of RipA. In particular, E61V, M31G and F60M RipA mutants show increased butyryl-CoA transferase activities when compared with wild-type RipA. Furthermore, the X-ray crystal structures of E61V, M31G and F60M RipA mutants, when compared with the wild-type RipA structure, reveal important conformational changes orchestrated by a conserved acyl-group binding-pocket phenylalanine, Phe85, and the G(V/I)G loop. Binary structures of M31G RipA and F60M RipA with two distinct CoA substrate conformations are also presented. Taken together, these data provide CoA transferase reaction snapshots of an open apo RipA, a closed glutamyl-anhydride intermediate and an open CoA-thioester intermediate. Furthermore, biochemical analyses support essential roles for both the catalytic glutamate and the flexible G(V/I)G loop along the reaction pathway, although further research is required to fully

  15. MLVA Based Classification of Mycobacterium tuberculosis Complex Lineages for a Robust Phylogeographic Snapshot of Its Worldwide Molecular Diversity

    Science.gov (United States)

    Hill, Véronique; Zozio, Thierry; Sadikalay, Syndia; Viegas, Sofia; Streit, Elisabeth; Kallenius, Gunilla; Rastogi, Nalin

    2012-01-01

    Multiple-locus variable-number tandem repeat analysis (MLVA) is useful to establish transmission routes and sources of infections for various microorganisms including Mycobacterium tuberculosis complex (MTC). The recently released SITVITWEB database contains 12-loci Mycobacterial Interspersed Repetitive Units – Variable Number of Tandem DNA Repeats (MIRU-VNTR) profiles and spoligotype patterns for thousands of MTC strains; it uses MIRU International Types (MIT) and Spoligotype International Types (SIT) to designate clustered patterns worldwide. Considering existing doubts on the ability of spoligotyping alone to reveal exact phylogenetic relationships between MTC strains, we developed a MLVA based classification for MTC genotypic lineages. We studied 6 different subsets of MTC isolates encompassing 7793 strains worldwide. Minimum spanning trees (MST) were constructed to identify major lineages, and the most common representative located as a central node was taken as the prototype defining different phylogenetic groups. A total of 7 major lineages with their respective prototypes were identified: Indo-Oceanic/MIT57, East Asian and African Indian/MIT17, Euro American/MIT116, West African-I/MIT934, West African-II/MIT664, M. bovis/MIT49, M.canettii/MIT60. Further MST subdivision identified an additional 34 sublineage MIT prototypes. The phylogenetic relationships among the 37 newly defined MIRU-VNTR lineages were inferred using a classification algorithm based on a bayesian approach. This information was used to construct an updated phylogenetic and phylogeographic snapshot of worldwide MTC diversity studied both at the regional, sub-regional, and country level according to the United Nations specifications. We also looked for IS6110 insertional events that are known to modify the results of the spoligotyping in specific circumstances, and showed that a fair portion of convergence leading to the currently observed bias in phylogenetic classification of strains may

  16. Recognition and management of acute kidney injury in children: The ISN 0by25 Global Snapshot study.

    Directory of Open Access Journals (Sweden)

    Etienne Macedo

    Full Text Available In low and middle-income countries, reliable data on the epidemiology of childhood acute kidney injury (AKI is lacking. The Global Snapshot, conducted by the ISN "0by25" AKI initiative, was a world-wide cross-sectional, observational study to evaluate AKI in hospitalized patients. Here we report the pediatric results of this study.We prospectively collected data on children who met the Kidney Disease Improving Global Outcomes AKI criteria during a 10-week window in late 2014. AKI risk factors, etiological factors, management and outcomes were recorded using standardized forms and protocols. Countries were classified according to their 2014 gross national income (GNI per person into high-income countries (HIC, upper-middle income countries (UMIC and low and low-middle income countries (LLMIC. Need for renal replacement therapy, mortality, and renal recovery were assessed 7 days after AKI diagnosis or at hospital discharge, whichever came first.92 centers from 41 countries collected data on 354 pediatric AKI patients; 53% of the children developed AKI while hospitalized and 47% in the community. The most common etiological factors for AKI differed across GNI categories as well as between patients with community-acquired vs. hospital-acquired AKI. Children from HIC were younger, and larger proportion of AKI in this group were due to post-surgical complications vs. other etiologies when compared to other income categories. In patients with hypotension as the cause of AKI, the adjusted risk of death was almost 10-fold higher compared to patients without hypotension as an etiological factor for AKI development. Mortality was similar within AKI stages in HIC and UMIC. In LLMIC, patients with the highest AKI level of severity had higher mortality than patients in higher income categories. Patients from LLMIC and UMIC had a 57-fold and 11 fold higher adjusted risk of death, respectively, compared to patients from HIC.In resource-limited countries

  17. Mortality associated with gastrointestinal bleeding events: Comparing short-term clinical outcomes of patients hospitalized for upper GI bleeding and acute myocardial infarction in a US managed care setting

    Directory of Open Access Journals (Sweden)

    C Mel Wilcox

    2009-03-01

    Full Text Available C Mel Wilcox1, Byron L Cryer2, Henry J Henk3, Victoria Zarotsky3, Gergana Zlateva41University of Alabama, Birmingham, AL, USA; 2University of Texas Southwestern Medical School, Dallas, TX; 3i3 Innovus, Eden Prairie, MN, USA; 4Pfizer, Inc., New York, NY, USA Objectives: To compare the short-term mortality rates of gastrointestinal (GI bleeding to those of acute myocardial infarction (AMI by estimating the 30-, 60-, and 90-day mortality among hospitalized patients.Methods: United States national health plan claims data (1999–2003 were used to identify patients hospitalized with a GI bleeding event. Patients were propensity-matched to AMI patients with no evidence of GI bleed from the same US health plan.Results: 12,437 upper GI-bleed patients and 22,847 AMI patients were identified. Propensity score matching yielded 6,923 matched pairs. Matched cohorts were found to have a similar Charlson Comorbidity Index score and to be similar on nearly all utilization and cost measures (excepting emergency room costs. A comparison of outcomes among the matched cohorts found that AMI patients had higher rates of 30-day mortality (4.35% vs 2.54%; p < 0.0001 and rehospitalization (2.56% vs 1.79%; p = 0.002, while GI bleed patients were more likely to have a repeat procedure (72.38% vs 44.95%; p < 0.001 following their initial hospitalization. The majority of the difference in overall 30-day mortality between GI bleed and AMI patients was accounted for by mortality during the initial hospitalization (1.91% vs 3.58%.Conclusions: GI bleeding events result in significant mortality similar to that of an AMI after adjusting for the initial hospitalization.Keywords: gastrointestinal, bleeding, mortality, acute myocardial infarction, claims analysis

  18. Lipopolysaccharide (LPS) and tumor necrosis factor alpha (TNFα) blunt the response of Neuropeptide Y/Agouti-related peptide (NPY/AgRP) glucose inhibited (GI) neurons to decreased glucose.

    Science.gov (United States)

    Hao, Lihong; Sheng, Zhenyu; Potian, Joseph; Deak, Adam; Rohowsky-Kochan, Christine; Routh, Vanessa H

    2016-10-01

    A population of Neuropeptide Y (NPY) neurons which co-express Agouti-related peptide (AgRP) in the arcuate nucleus of the hypothalamus (ARC) are inhibited at physiological levels of brain glucose and activated when glucose levels decline (e.g. glucose-inhibited or GI neurons). Fasting enhances the activation of NPY/AgRP-GI neurons by low glucose. In the present study we tested the hypothesis that lipopolysaccharide (LPS) inhibits the enhanced activation of NPY/AgRP-GI neurons by low glucose following a fast. Mice which express green fluorescent protein (GFP) on their NPY promoter were used to identify NPY/AgRP neurons. Fasting for 24h and LPS injection decreased blood glucose levels. As we have found previously, fasting increased c-fos expression in NPY/AgRP neurons and increased the activation of NPY/AgRP-GI neurons by decreased glucose. As we predicted, LPS blunted these effects of fasting at the 24h time point. Moreover, the inflammatory cytokine tumor necrosis factor alpha (TNFα) blocked the activation of NPY/AgRP-GI neurons by decreased glucose. These data suggest that LPS and TNFα may alter glucose and energy homeostasis, in part, due to changes in the glucose sensitivity of NPY/AgRP neurons. Interestingly, our findings also suggest that NPY/AgRP-GI neurons use a distinct mechanism to sense changes in extracellular glucose as compared to our previous studies of GI neurons in the adjacent ventromedial hypothalamic nucleus. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. Investigation of pH and Temperature Profiles in the GI Tract of Fasted Human Subjects Using the Intellicap(®) System.

    Science.gov (United States)

    Koziolek, Mirko; Grimm, Michael; Becker, Dieter; Iordanov, Ventzeslav; Zou, Hans; Shimizu, Jeff; Wanke, Christoph; Garbacz, Grzegorz; Weitschies, Werner

    2015-09-01

    Gastrointestinal (GI) pH and temperature profiles under fasted-state conditions were investigated in two studies with each 10 healthy human subjects using the IntelliCap(®) system. This telemetric drug delivery device enabled the determination of gastric emptying time, small bowel transit time, and colon arrival time by significant pH and temperature changes. The study results revealed high variability of GI pH and transit times. The gastric transit of IntelliCap(®) was characterized by high fluctuations of the pH with mean values ranging from pH 1.7 to pH 4.7. Gastric emptying was observed after 7-202 min (median: 30 min). During small bowel transit, which had a duration of 67-532 min (median: 247 min), pH values increased slightly from pH 5.9-6.3 in proximal parts to pH 7.4-7.8 in distal parts. Colonic pH conditions were characterized by values fluctuating mainly between pH 5 and pH 8. The pH profiles and transit times described in this work are highly relevant for the comprehension of drug delivery of solid oral dosage forms comprising ionizable drugs and excipients with pH-dependent solubility. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.

  20. Hemoglobin, ferritin, vitamin B12 and helicobacter pylori infection: a study in patients underwent upper GI endoscopy at civil hospital karachi

    International Nuclear Information System (INIS)

    Zuberi, B.F.; Asar, S.; Qadeer, R.; Baloch, I.; Saeed, M.

    2007-01-01

    To compare hemoglobin, ferritin, and vitamin B12 levels in patients undergoing upper GI endoscopy according to their Helicobacter pylori status. All patients undergoing upper GI Endoscopy were selected, while patients of active peptic ulcers, malignancy, varices, malabsorption and recent blood donation were excluded. Blood samples for CBC, serum ferritin and vitamin B12 were collected and H.pylori status was ascertained by urease test on gastric biopsy. Differences in mean values of age, ferritin, hemoglobin, MCV and vitamin B12 were done by students t-test. Significant confounding factors were identified on multivariate analysis and were further analyzed by univariate analysis. Two hundred and eighty-five subjects were studied, including 171 males and 114 females. H-pylori was positive in 214 (75.1%) patients. Significantly low levels of hemoglobin (p =0.0), ferritin (p = 0.0) and vitamin B12 (p = 0.0) were found in patients with H-pylori infection. Gender, menopause, contraception and history of peptic ulcer disease were identified as significant confounders. Significantly low levels of hemoglobin, ferritin and vitamin B12 were found in patients with H-pylori infection. (author)