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Sample records for quadrupole magnetic sorting

  1. Superconducting magnetic quadrupole

    Energy Technology Data Exchange (ETDEWEB)

    Kim, J.W.; Shepard, K.W.; Nolen, J.A.

    1995-08-01

    A design was developed for a 350 T/m, 2.6-cm clear aperture superconducting quadrupole focussing element for use in a very low q/m superconducting linac as discussed below. The quadrupole incorporates holmium pole tips, and a rectangular-section winding using standard commercially-available Nb-Ti wire. The magnet was modeled numerically using both 2D and 3D codes, as a basis for numerical ray tracing using the quadrupole as a linac element. Components for a prototype singlet are being procured during FY 1995.

  2. SPS Quadrupole Magnets

    CERN Multimedia

    1974-01-01

    A stack of SPS Quadrupole Magnets ready for installation in the tunnel. The SPS uses a total of 216 laminated normal conducting lattice quadrupoles with a length of 3.13 m for the core, 3.3 m overall. The F and D quads. have identical characteristics: inscribed circle radius 44 mm, core height and width 800 mm, maximum gradient 20 Tesla/m.

  3. AA quadrupole magnet

    CERN Multimedia

    1980-01-01

    Focusing magnet used for the AA (antiproton accumulator).Making an antiproton beam took a lot of time and effort. Firstly, protons were accelerated to an energy of 26 GeV in the PS and ejected onto a metal target. From the spray of emerging particles, a magnetic horn picked out 3.6 GeV antiprotons for injection into the AA through a wide-aperture focusing quadrupole magnet. For a million protons hitting the target, just one antiproton was captured, 'cooled' and accumulated. It took 3 days to make a beam of 3 x 10^11 - three hundred thousand million - antiprotons. About focusing magnets (quadrupoles): Quadrupole magnets are needed to focus the particle beams and squeeze them so that more particles collide when the beams cross. Particle beams are stored for about 10 hours in the LHC. During this time, the particles make four hundred million revolutions around the machine, travelling a distance equivalent to the diameter of the solar system.

  4. Model of an LHC superconducting quadrupole magnet

    CERN Multimedia

    Laurent Guiraud

    2000-01-01

    Model of a superconducting quadrupole magnet for the LHC project. These magnets are used to focus the beam by squeezing it into a smaller cross-section, a similar effect to a lens focusing light. However, each magnet only focuses the beam in one direction so alternating magnet arrangements are required to produce a fully focused beam.

  5. Electro-Magnetic Quadrupole Magnets in the LCLS FEL Undulator

    Energy Technology Data Exchange (ETDEWEB)

    Emma, P.

    2005-01-31

    We discuss various aspects of electro-magnetic quadrupole (EMQ) magnets for the LCLS FEL undulator, including their utility in beam-based alignment (BBA), magnet design issues, and impact on tunnel environment, reliability, and cost.

  6. Tunable high-gradient permanent magnet quadrupoles

    CERN Document Server

    Shepherd, B J A; Marks, N; Collomb, N A; Stokes, D G; Modena, M; Struik, M; Bartalesi, A

    2014-01-01

    A novel type of highly tunable permanent magnet (PM) based quadrupole has been designed by the ZEPTO collaboration. A prototype of the design (ZEPTO-Q1), intended to match the specification for the CLIC Drive Beam Decelerator, was built and magnetically measured at Daresbury Laboratory and CERN. The prototype utilises two pairs of PMs which move in opposite directions along a single vertical axis to produce a quadrupole gradient variable between 15 and 60 T/m. The prototype meets CLIC's challenging specification in terms of the strength and tunability of the magnet.

  7. Splice testing for LHC quadrupole magnets

    CERN Document Server

    Barzi, E; Fehér, S; Kashikhin, V V; Kerby, J S; Lamm, M J; Orris, D; Ray, G; Tartaglia, M; Zlobin, A V

    2003-01-01

    Electrical splices between NbTi Rutherford type cables need to be made for the LHC IR inner triplet quadrupoles. Splices between magnets as well as internal to the magnets are necessary. Various splice configurations, solders, and fluxes have been considered. Testing of these splices at cryogenic temperatures and at various currents has been completed. The results were satisfactory; Fermilab is capable of making excellent low resistance (<1n Omega ) solder joints for the LHC project. (4 refs).

  8. A Compact High Gradient Pulsed Magnetic Quadrupole

    CERN Document Server

    Shuman, Derek; Kireeff Covo, Michel; Ritchie, Gary; Seidl, Peter

    2005-01-01

    A design for a high gradient, low inductance pulsed quadrupole magnet is presented. The magnet is a circular current dominated design with a circular iron return yoke. Features include a five turn eddy current compensated solid conductor coil design which theoretically eliminates the first four higher order multipole field components, a single layer "non-spiral bedstead" coil design which both minimizes utilization of radial space and maximizes utilization of axial space, and allows incorporation of steering and correction coils within existing radial space. The coils are wound and stretched straight in a special winder, then bent in simple fixtures to form the upturned ends, simplifying fabrication and assembly.

  9. Hybrid high gradient permanent magnet quadrupole

    Science.gov (United States)

    N'gotta, P.; Le Bec, G.; Chavanne, J.

    2016-12-01

    This paper presents an innovative compact permanent magnet quadrupole with a strong gradient for potential use in future light source lattices. Its magnetic structure includes simple mechanical parts, rectangular permanent magnet blocks and soft iron poles. It has a wide aperture in the horizontal plane to accommodate an x-ray beam port, a common constraint in storage ring-based light sources. This specificity introduces field quality deterioration because of the resulting truncation of the poles; a suitable field quality can be restored with an optimized pole shape. A 82 T /m prototype with a bore radius of 12 mm and a 10 mm vertical gap between poles has been constructed and magnetically characterized. Gradient inhomogeneities better than 10-3 in the good field region were obtained after the installation of special shims.

  10. Quadrupole magnet for a rapid cycling synchrotron

    Energy Technology Data Exchange (ETDEWEB)

    Witte, H. [Brookhaven National Lab. (BNL), Upton, NY (United States); Berg, J. S. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-05-03

    Rapid Cycling Synchrotrons (RCS) feature interleaved warm and cold dipole magnets; the field of the warm magnets is used to modulate the average bending field depending on the particle energy. It has been shown that RCS can be an attractive option for fast acceleration of particles, for example, muons, which decay quickly. In previous studies it was demonstrated that in principle warm dipole magnets can be designed which can provide the required ramp rates, which are equivalent to frequencies of about 1 kHz. To reduce the losses it is beneficial to employ two separate materials for the yoke; it was also shown that by employing an optimized excitation coil geometry the eddy current losses are acceptable. In this paper we show that the same principles can be applied to quadrupole magnets targeting 30 T/m with a repetition rate of 1kHz and good field quality.

  11. Quench Protection of the LHC Quadrupole Magnets

    CERN Document Server

    Kurfuerst, Christoph; Dehning, Bernd; Sapoinski, Mariusz

    2010-01-01

    CERNs Large Hadron Collider (LHC) is a new high energy proton accelerator and storage ring. Its design allows to reach unprecedented beam energies and beam intensities, resulting in a largely increased particle physics discovery potential. The combination of its high beam energy and intensity may lead to beam losses which can have a severe impact on the LHC equipment and damage sensitive elements. To protect those and to measure operational losses, a Beam Loss Monitoring system has been installed all along the ring. The protection is achieved by extracting the beam from the ring in case thresholds imposed on measured radiation levels are exceeded. The thresholds are estimated through particle shower simulations. The simulated geometry and physic processes need to be precise in order to determine an optimum value, which therefore assures a high availability of the LHC for operation. This study is focused on the interconnection region between the main dipole and the main quadrupole magnet of the LHC. Six monito...

  12. Magnetic mirror structure for testing shell-type quadrupole coils

    Energy Technology Data Exchange (ETDEWEB)

    Andreev, N.; Barzi, E.; Bossert, R.; Chlachidze, G.; Kashikhin, V.S.; Kashikhin, V.V.; Lamm, M.J.; Nobrega, F.; Novitski, I.; Tartaglia, N.; Turrioni, D.; /Fermilab

    2009-10-01

    This paper presents magnetic and mechanical designs and analyses of the quadrupole mirror structure to test single shell-type quadrupole coils. Several quadrupole coils made of different Nb{sub 3}Sn strands, cable insulation and pole materials were tested using this structure at 4.5 and 1.9 K. The coils were instrumented with voltage taps, spot heaters, temperature sensors and strain gauges to study their mechanical and thermal properties and quench performance. The results of the quadrupole mirror model assembly and test are reported and discussed.

  13. Magnetic mirror structure for testing shell-type quadrupole coils

    Energy Technology Data Exchange (ETDEWEB)

    Andreev, N.; Barzi, E.; Bossert, R.; Chlachidze, G.; Kashikhin, V.S.; Kashikhin, V.V.; Lamm, M.J.; Nobrega, F.; Novitski, I.; Tartaglia, N.; Turrioni, D.; /Fermilab

    2009-10-01

    This paper presents magnetic and mechanical designs and analyses of the quadrupole mirror structure to test single shell-type quadrupole coils. Several quadrupole coils made of different Nb{sub 3}Sn strands, cable insulation and pole materials were tested using this structure at 4.5 and 1.9 K. The coils were instrumented with voltage taps, spot heaters, temperature sensors and strain gauges to study their mechanical and thermal properties and quench performance. The results of the quadrupole mirror model assembly and test are reported and discussed.

  14. Harmonic analysis and field quality improvement of an HTS quadrupole magnet for a heavy ion accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Zhan; Wei, Shaoqing; Lee, Sang Jin [Uiduk University, Gyeongju (Korea, Republic of); Jo, Hyun Chul; Kim, Do Gyun; Kim, Jong Won [Rare Isotope Science Project, Institute for Basic Science, Daejeon (Korea, Republic of)

    2016-06-15

    In recent years, the iron-dominated high-temperature superconductor (HTS) quadrupole magnets are being developed for heavy ion accelerators. Field analyses for iron-dominated quadrupole magnets were based on the normal-conducting (NC) quadrupole magnet early in the development for accelerators. Some conclusions are still in use today. However, the magnetic field of iron-dominated HTS quadrupole magnets cannot fully follow these conclusions. This study established an HTS quadrupole magnet model and an NC quadrupole magnet model, respectively. The harmonic characteristics of two magnets were analyzed and compared. According to the comparison, the conventional iron-dominated quadrupole magnets can be designed for maximum field gradient; the HTS quadrupole magnet, however, should be considered with varying field gradient. Finally, the HTS quadrupole magnet was designed for the changing field gradient. The field quality of the design was improved comparing with the result of the previous study. The new design for the HTS quadrupole magnet has been suggested.

  15. Intrinsic Third Order Aberrations in Electrostatic and Magnetic Quadrupoles

    CERN Document Server

    Baartman, R

    2015-01-01

    Intrinsic aberrations are those which occur due to the finite length of the desired field configuration. They are often loosely ascribed to the fringing field. This is misleading as it implies that the effects can be minimized by shaping the fields. In fact, there is an irreducible component related to the broken symmetry. It is present even in the hard-edge limit, and moreover, the other (soft-edge) effects can be simply ascribed to the intrinsic aberration spread over a finite length. We rederive the aberration formulas for quadrupoles using a Hamiltonian formalism. This allows for an easy comparison of electrostatic and magnetic quadrupoles. For different combinations of large and small emittances in the two transverse planes, it is found that in some situations electrostatic quadrupoles have lower aberrations, while in others, magnetic quadrupoles are better. As well, we discuss the ways in which existing transport codes handle quadrupole fringe fields. Pitfalls are pointed out and improvements proposed.

  16. High-throughput magnetic flow sorting of human cells selected on the basis of magnetophoretic mobility

    Science.gov (United States)

    Reece, Lisa M.; Sanders, Lehanna; Kennedy, David; Guernsey, Byron; Todd, Paul; Leary, James F.

    2010-02-01

    We have shown the potential of a new method for optimizing the separation of human stem cell subsets from peripheral blood based on a novel cell labeling technique that leverages the capabilities of a new commercially available high speed magnetic cell sorting system (IKOTECH LLC, New Albany, IN). This new system sorts cells in a continuously flowing manner using a Quadrupole Magnetic cell Sorter (QMS). The sorting mechanism is based upon the magnetophoretic mobility of the cells, a property related to the relative binding distributions of magnetic particles per cell, as determined by the utilization of a Magnetic Cell Tracking Velocimeter (MCTV). KG-1 cells were competitively labeled with anti-CD34 magnetic beads and anti-CD34 FITC to obtain an optimal level of magnetophoretic mobility as visualized by the MCTV for high throughput sort recovery in the QMS. In QMS sorting, the concept of split-flow thin channel (SPLITT) separation technology is applied by having a sample stream enter a vertical annular flow channel near the channel's interior wall followed by another sheath flow entering near the exterior wall. The two flows are initially separated by a flow splitter. They pass through the bore of a Halbach permanent quadrupole magnet assembly, which draws magnetized cells outward and deflects them into a positive outflow, while negative cells continue straight out via the inner flow lamina. QMS sorts cells based upon their magnetophoretic mobility, or the velocity of a cell per unit ponderomotive force, the counterpart of fluorescence intensity in flow cytometry. The magnetophoretic mobility distribution of a cell population, measured by automated MCTV, is used as input data for the algorithmic control of sample, sheath, and outlet flow velocities of the QMS. In this study, the relative binding distributions of magnetic particles per cell were determined by MCTV using novel sorting and sizing algorithms. The resulting mobility histograms were used to set the QMS

  17. Conceptual design of a quadrupole magnet for eRHIC

    Energy Technology Data Exchange (ETDEWEB)

    Witte, H. [Brookhaven National Lab. (BNL), Upton, NY (United States); Berg, J. S. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-05-03

    eRHIC is a proposed upgrade to the existing Relativistic Heavy Ion Collider (RHIC) hadron facility at Brookhaven National Laboratory, which would allow collisions of up to 21 GeV polarized electrons with a variety of species from the existing RHIC accelerator. eRHIC employs an Energy Recovery Linac (ERL) and an FFAG lattice for the arcs. The arcs require open-midplane quadrupole magnets of up to 30 T/m gradient of good field quality. In this paper we explore initial quadrupole magnet design concepts based on permanent magnetic material which allow to modify the gradient during operation.

  18. Permanent magnet quadrupoles for the CLIC Drive Beam decelerator

    CERN Document Server

    Shepherd, Ben; Collomb, Norbert

    2012-01-01

    STFC in collaboration with CERN has developed a new type of adjustable permanent magnet based quadrupole for the CLIC Drive Beam Decelerator. It uses vertical movement of the permanent magnets to achieve an integrated gradient range of 3.6-14.6T, which will allow it to be used for the first 60% of the decelerator line. Construction of a prototype of this magnet has begun; following this, it will be measured magnetically at CERN and Daresbury Laboratory.

  19. Wooden models of an AA quadrupole between bending magnets

    CERN Multimedia

    1978-01-01

    At two points in the AA lattice, a quadrupole (QDN, defocusing, narrow) was tightly wedged between two bending magnets (BST, short, wide). This picture of wooden models lets one imagine the strong interaction between their magnetic fields. There was no way one could calculate with the necessary accuracy the magnetic effects and their consequences for the machine optics. The necessary corrections were made after measurements with a circulating beam, in a tedious iterative procedure, with corrrection coils and shims.

  20. Magnetic fluid equipment for sorting of secondary polyolefins from waste

    NARCIS (Netherlands)

    Rem, P.C.; Di Maio, F.; Hu, B.; Houzeaux, G...; Baltes, L.; Tierean, M.

    2012-01-01

    The paper presents the researches made on the FP7 project „Magnetic Sorting and Ultrasound Sensor Technologies for Production of High Purity Secondary Polyolefins from Waste” in order to develop a magnetic fluid equipment for sorting of polypropylene (PP) and polyethylene (PE) from polymers mixed

  1. Magnetic fluid equipment for sorting of secondary polyolefins from waste

    NARCIS (Netherlands)

    Rem, P.C.; Di Maio, F.; Hu, B.; Houzeaux, G...; Baltes, L.; Tierean, M.

    2012-01-01

    The paper presents the researches made on the FP7 project „Magnetic Sorting and Ultrasound Sensor Technologies for Production of High Purity Secondary Polyolefins from Waste” in order to develop a magnetic fluid equipment for sorting of polypropylene (PP) and polyethylene (PE) from polymers mixed wa

  2. Performance of an Adjustable Strength Permanent Magnet Quadrupole

    CERN Document Server

    Gottschalk, Stephen C; Kangas, Kenneth; Spencer, Cherrill M; Volk, James T

    2005-01-01

    An adjustable strength permanent magnet quadrupole suitable for use in Next Linear Collider has been built and tested. The pole length is 42cm, aperture diameter 13mm, peak pole tip strength 1.03Tesla and peak integrated gradient * length (GL) is 68.7 Tesla. This paper describes measurements of strength, magnetic centerline and field quality made using an air bearing rotating coil system. The magnetic centerline stability during -20% strength adjustment proposed for beam based alignment was < 0.2 microns. Strength hysteresis was negligible. Thermal expansion of quadrupole and measurement parts caused a repeatable and easily compensated change in the vertical magnetic centerline. Calibration procedures as well as centerline measurements made over a wider tuning range of 100% to 20% in strength useful for a wide range of applications will be described. The impact of eddy currents in the steel poles on the magnetic field during strength adjustments will be reported.

  3. Comparison of conventional and novel quadrupole drift tube magnets inspired by Klaus Halbach

    Energy Technology Data Exchange (ETDEWEB)

    Feinberg, B. [Lawrence Berkeley Lab., CA (United States)

    1995-02-01

    Quadrupole drift tube magnets for a heavy-ion linac provide a demanding application of magnet technology. A comparison is made of three different solutions to the problem of providing an adjustable high-field-strength quadrupole magnet in a small volume. A conventional tape-wound electromagnet quadrupole magnet (conventional) is compared with an adjustable permanent-magnet/iron quadrupole magnet (hybrid) and a laced permanent-magnet/iron/electromagnet (laced). Data is presented from magnets constructed for the SuperHILAC heavy-ion linear accelerator, and conclusions are drawn for various applications.

  4. Development of a $Nb_{3}$Sn quadrupole magnet model

    CERN Document Server

    Devred, Arnaud; Gourdin, C; Juster, F P; Peyrot, M; Rey, J M; Rifflet, J M; Streiff, J M; Védrine, P

    2001-01-01

    One possible application of Nb/sub 3/Sn, whose superconducting properties far exceed those of NbTi, is the fabrication of short and powerful quadrupole magnets for the crowded interaction regions of large particle accelerators. To learn about Nb/sub 3/Sn technology and to evaluate fabrication techniques, DAPNIA/STCM at CEA/Saclay has undertaken an R&D program aimed at designing and building a 1 m-long, 56 mm single-aperture quadrupole magnet model. The model relies on the same coil geometry as the LHC arc quadrupole magnets, but has no iron yoke. It is expected to produce a nominal field gradient of 211 T/m at 11870 A. The coils are wound from Rutherford-type cables insulated with quartz fiber tapes, before being heat-treated and vacuum-impregnated with epoxy resin. Laminated, austenitic collars, locked around the coil assembly by means of keys restrain the Lorentz forces. After reviewing the conceptual design of the magnet model, we report on the cable and cable insulation development programs and we pre...

  5. Cool Down Analysis of a Cryocooler Based Quadrupole Magnet Cryostat

    Science.gov (United States)

    Choudhury, A.; Kar, S.; Chacko, J.; Kumar, M.; Babu, S.; Sahu, S.; Kumar, R.; Antony, J.; Datta, T. S.

    A superconducting quadrupole doublet magnet with cold superferric iron cover for the Hybrid Recoil Mass Analyzer (HYRA) beam line has been commissioned. The total cold mass of the helium vessel with iron yoke and pole is 2 ton. A set of two Sumitomo cryocoolers take care of various heat loads to the cryostat. The first successful cool down of the cryostat has been completed recently, magnets have been powered and magnetic field profiling has been done inside theroom temperature beam tube. This paper will highlight the cryostat details along with the cool down and operational test results obtained from the first cool down.

  6. Faster magnet sorting with a threshold acceptance algorithm

    Science.gov (United States)

    Lidia, Steve; Carr, Roger

    1995-02-01

    We introduce here a new technique for sorting magnets to minimize the field errors in permanent magnet insertion devices. Simulated annealing has been used in this role, but we find the technique of threshold acceptance produces results of equal quality in less computer time. Threshold accepting would be of special value in designing very long insertion devices, such as long free electron lasers (FELs). Our application of threshold acceptance to magnet sorting showed that it converged to equivalently low values of the cost function, but that it converged significantly faster. We present typical cases showing time to convergence for various error tolerances, magnet numbers, and temperature schedules.

  7. Precision Alignments of Stripline BPMs with Quadrupole Magnets for TTF2

    CERN Document Server

    Priebe, G; Wendt, M; Werner, M

    2004-01-01

    We report on our alignment setup to calibrate beam position monitors (BPM) with respect to the magnetic axis of the quadrupole magnets used in the warm sections of the TESLA Test Facility (TTF2). The Stripline BPM's are fixed inside the quadrupole magnets. A streched wire measurement was used to calibrate the electrical axis of the BPM wrt. to the magnetic axis of the quadrupole.

  8. Kick velocity induced by magnetic dipole and quadrupole radiation

    CERN Document Server

    Kojima, Yasufumi

    2010-01-01

    We examine the recoil velocity induced by the superposition of the magnetic dipole and quadrupole radiation from a pulsar/magnetar born with rapid rotation. The resultant velocity depends on not the magnitude, but rather the ratio of the two moments and their geometrical configuration. The model does not necessarily lead to high spatial velocity for a magnetar with a strong magnetic field, which is consistent with the recent observational upper bound. The maximum velocity predicted with this model is slightly smaller than that of observed fast-moving pulsars.

  9. Sorting of bending magnets for the SSRF booster

    Institute of Scientific and Technical Information of China (English)

    HOU Jie; LIU Gui-Min; LI Hao-Hu; ZHANG Man-Zhou

    2008-01-01

    The Shanghai Synchrotron Radiation Facility(SSRF)booster ring,a full energy injector for the storage ring,is deigned to accelerate the electron beam energy from 150MeV to 3.5GeV that demands high extraction efficiency at the extraction energy with low beam loss rate when electrons are ramping.Closed orbit distortion(COD)caused by bending magnet field uniformity errors which affects the machine performance harmfully could be effectively reduced by bending magnet location sorting.Considering the affections of random errors in measurement,both ideal sorting and realistic sorting are studied based on measured bending magnet field uniformity errors and one reasonable combination of bending magnets which can reduce the horizontal COD by a factor of 5is given as the final installation sequence of the booster bending magnets in this paper.

  10. Sorting of bending magnets for the SSRF booster

    Science.gov (United States)

    Hou, Jie; Liu, Gui-Min; Li, Hao-Hu; Zhang, Man-Zhou

    2008-04-01

    The Shanghai Synchrotron Radiation Facility (SSRF)booster ring, a full energy injector for the storage ring, is deigned to accelerate the electron beam energy from 150 MeV to 3.5 GeV that demands high extraction efficiency at the extraction energy with low beam loss rate when electrons are ramping. Closed orbit distortion (COD) caused by bending magnet field uniformity errors which affects the machine performance harmfully could be effectively reduced by bending magnet location sorting. Considering the affections of random errors in measurement, both ideal sorting and realistic sorting are studied based on measured bending magnet field uniformity errors and one reasonable combination of bending magnets which can reduce the horizontal COD by a factor of 5 is given as the final installation sequence of the booster bending magnets in this paper. Supported by SSRF Project

  11. Design, simulation and construction of quadrupole magnets for focusing electron beam in powerful industrial electron accelerator

    Directory of Open Access Journals (Sweden)

    S KH Mousavi

    2015-09-01

    Full Text Available In this paper the design and simulation of quadrupole magnets and electron beam optical of that by CST Studio code has been studied. Based on simulation result the magnetic quadrupole has been done for using in beam line of first Iranian powerful electron accelerator. For making the suitable magnetic field the effects of material and core geometry and coils current variation on quadrupole magnetic field have been studied. For test of quadrupole magnet the 10 MeV beam energy and 0.5 pi mm mrad emittance of input beam has been considered. We see the electron beam through the quadrupole magnet focus in one side and defocus in other side. The optimum of distance between two quadrupole magnets for low emittance have been achieved. The simulation results have good agreement with experimental results

  12. Sorting and Manipulation of Magnetic Droplets in Continuous Flow

    Science.gov (United States)

    Al-Hetlani, Entesar; Hatt, Oliver J.; Vojtíšek, Martin; Tarn, Mark D.; Iles, Alexander; Pamme, Nicole

    2010-12-01

    We report the rapid on-chip generation and subsequent manipulation of magnetic droplets in continuous flow. Magnetic droplets were formed using aqueous-based ferrofluid as the dispersed phase and fluorocarbon oil as the continuous phase. Droplet manipulation was demonstrated with simple permanent magnets using two microfluidic platforms: (i) flow focusing droplet generation followed by their splitting into daughter droplets containing different amounts of magnetic nanoparticles, and (ii) droplet generation at a T-junction and their downstream deflection across a chamber for sorting based on the applied magnetic field and magnetite loading of the droplet. Both systems show great potential for performing a wide range of high throughput continuous flow processes including sample dilution, cell sorting and screening, and microparticle fabrication.

  13. Shrink-induced sorting using integrated nanoscale magnetic traps.

    Science.gov (United States)

    Nawarathna, Dharmakeerthi; Norouzi, Nazila; McLane, Jolie; Sharma, Himanshu; Sharac, Nicholas; Grant, Ted; Chen, Aaron; Strayer, Scott; Ragan, Regina; Khine, Michelle

    2013-02-11

    We present a plastic microfluidic device with integrated nanoscale magnetic traps (NSMTs) that separates magnetic from non-magnetic beads with high purity and throughput, and unprecedented enrichments. Numerical simulations indicate significantly higher localized magnetic field gradients than previously reported. We demonstrated >20 000-fold enrichment for 0.001% magnetic bead mixtures. Since we achieve high purity at all flow-rates tested, this is a robust, rapid, portable, and simple solution to sort target species from small volumes amenable for point-of-care applications. We used the NSMT in a 96 well format to extract DNA from small sample volumes for quantitative polymerase chain reaction (qPCR).

  14. $Nb_{3}Sn$ quadrupole magnets for the LHC IR

    CERN Document Server

    Sabbi, G L; Chiesa, L; Coccoli, M; Dietderich, D R; Ferracin, P; Gourlay, S A; Hafalia, R R; Lietzke, A F; McInturff, A D; Scanlan, R M

    2003-01-01

    The development of insertion quadrupoles with 205 T/m gradient and 90 mm bore represents a promising strategy to achieve the ultimate luminosity goal of 2.5 * 10/sup 34/ cm/sup -2/s/sup -1/ at the Large Hadron Collider (LHC). At present, Nb/sub 3/Sn is the only practical conductor which can meet these requirements. Since Nb/sub 3/Sn is brittle, and considerably more strain sensitive than NbTi, the design concepts and fabrication techniques developed for NbTi magnets need to be modified appropriately. In addition, IR magnets must provide high field quality and operate reliably under severe radiation loads. The results of conceptual design studies addressing these issues are presented. (25 refs).

  15. Nuclear magnetic and quadrupole resonance studies of the stripes materials

    Energy Technology Data Exchange (ETDEWEB)

    Grafe, H.-J., E-mail: h.grafe@ifw-dresden.de [IFW Dresden, Institute for Solid State Research, P.O. Box 270116, D-01171 Dresden (Germany)

    2012-11-01

    Nuclear Magnetic and Quadrupole Resonance (NMR/NQR) is a powerful tool to probe electronic inhomogeneities in correlated electron systems. Its local character allows for probing different environments due to spin density modulations or inhomogeneous doping distributions emerging from the correlations in these systems. In fact, NMR/NQR is not only sensitive to magnetic properties through interaction of the nuclear spin, but also allows to probe the symmetry of the charge distribution and its homogeneity, as well as structural modulations, through sensitivity to the electric field gradient (EFG). We review the results of NMR and NQR in the cuprates from intrinsic spatial variations of the hole concentration in the normal state to stripe order at low temperatures, thereby keeping in mind the influence of doping induced disorder and inhomogeneities. Finally, we briefly discuss NQR evidence for local electronic inhomogeneities in the recently discovered iron pnictides, suggesting that electronic inhomogeneities are a common feature of correlated electron systems.

  16. Stability considerations of permanent magnet quadrupoles for CESR phase-III upgrade

    Directory of Open Access Journals (Sweden)

    W. Lou

    1998-06-01

    Full Text Available The Cornell electron storage ring (CESR phase-III upgrade plan includes very strong permanent magnet quadrupoles in front of the cryostat for the superconducting quadrupoles and physically as close as possible to the interaction point. Together with the superconducting quadrupoles, they provide tighter vertical focusing at the interaction point. The quadrupoles are built with neodymium iron boron (NdFeB material and operate inside the 15 kG solenoid field. Requirements on the field quality and stability of these quadrupoles are discussed and test results are presented.

  17. Magnetic fringe field interference between the quadrupole and corrector magnets in the CSNS/RCS

    Science.gov (United States)

    Yang, Mei; Kang, Wen; Deng, Changdong; Sun, Xianjing; Li, Li; Wu, Xi; Gong, Lingling; Cheng, Da; Zhu, Yingshun; Chen, Fusan

    2017-03-01

    The Rapid Cycling Synchrotron (RCS) of the China Spallation Neutron Source (CSNS) employs large aperture quadrupole and corrector magnets with small aspect ratios and relatively short iron to iron separations; so the fringe field interference becomes serious which results in integral field strength reduction and extra field harmonics. We have performed 3D magnetic field simulations to investigate the magnetic field interference in the magnet assemblies and made some adjustments on the magnet arrangement. The Fourier analysis is used to quantify the integral gradient reduction and field harmonic changes of the quadrupole magnets. Some magnetic field measurements are undertaken to verify the simulation results. The simulation details and the major results are presented in this paper.

  18. Measurement, analysis and modification of the fifth-order fringe field components of magnetic quadrupole lenses

    Energy Technology Data Exchange (ETDEWEB)

    Moloney, G.R.; Jamieson, D.N.; Legge, G.J.F. (School of Physics, Univ. of Melbourne, Parkville (Australia))

    1991-03-01

    Extensive, quantitative measurements of magnetic quadrupole lens fringe fields have been conducted. The fringe field region of magnetic quadrupole lenses has been shown to contain significant contamination by higher-order multipole fields. These multipole components will contribute to the aberration coefficients of the lens. One of the largest components is the duodecapole component, which contributes to the fifth-order geometric aberrations of the lens. The measured multipole profiles in the fringe field region of the Melbourne quadrupoles are presented. We also present the results of an investigation into the effect of modifying the quadrupole pole tip profile at the pole ends. (orig.).

  19. Nuclear magnetic and quadrupole resonance in metallic powders in the presence of strong quadrupole interaction: Rhenium metal

    Energy Technology Data Exchange (ETDEWEB)

    Dimitropoulos, C.; Maglione, M.; Borsa, F.

    1988-03-01

    The nuclear-magnetic-resonance and nuclear-quadrupole-resonance (NQR-NMR) spectra of /sup 187/Re and /sup 185/Re in a powder of rhenium metal were measured in the temperature range 5--10 K both in zero field and with an external magnetic field. The zero-field NQR spectrum is severely broadened by a nonuniform distribution of quadrupole interactions. The average quadrupole coupling frequencies measured at 5 K are, for the two isotopes, ..nu../sub Q/ = 39 +- 0.2 MHz (/sup 187/Re) and ..nu../sub Q/ = 40.8 +- 0.3 MHz (/sup 185/Re). The spectra obtained in the presence of an external magnetic field can be interpreted satisfactorily in terms of transitions among the eigenstates of the full Hamiltonian (Zeeman plus quadrupolar). Measurements of relaxation rates yield T/sub 1/T = 0.03 sK, indicating a relaxation mechanism driven by the hyperfine interaction with the conduction electrons. The feasibility of NQR-NMR studies in small metal particles in the presence of strong inhomogeneous quadrupole interactions is assessed

  20. Large area magnetic micropallet arrays for cell colony sorting.

    Science.gov (United States)

    Cox-Muranami, Wesley A; Nelson, Edward L; Li, G P; Bachman, Mark

    2016-01-01

    A new micropallet array platform for adherent cell colony sorting has been developed. The platform consisted of thousands of square plastic pallets, 270 μm by 270 μm on each side, large enough to hold a single colony of cells. Each pallet included a magnetic core, allowing them to be collected with a magnet after being released using a microscope mounted laser system. The micropallets were patterned from 1002F epoxy resist and were fabricated on translucent, gold coated microscope slides. The gold layer was used as seed for electroplating the ferromagnetic cores within every individual pallet. The gold layer also facilitated the release of each micropallet during laser release. This array allows for individual observation, sorting and collection of isolated cell colonies for biological cell colony research. In addition to consistent release and recovery of individual colonies, we demonstrated stable biocompatibility and minimal loss in imaging quality compared to previously developed micropallet arrays.

  1. A summary of the quench behavior of B&W 1 m collider quadrupole model magnets

    Energy Technology Data Exchange (ETDEWEB)

    Rey, C.M.; Xu, M.F.; Hlasnicek, P.; Kelley, J.P.; Dixon, K.; Savignano, J.; Letterman, S.; Craig, P.; Maloney, J.; Boyes, D. [Babcock & Wilcox, Lynchburg, VA (United States)] [and others

    1994-12-31

    In order to evaluate the quench performance of a B&W-Siemens designed quadrupole magnet at the earliest possible stage, a model magnet program was developed at B&W for the support of the Superconducting Super Collider. The authors report the quench performance, training behavior, and the ramp rate dependence for the QSH-801 through QSH-804 series of short (1.2 meter) quadrupole model magnets.

  2. Wireless power transfer based on magnetic quadrupole coupling in dielectric resonators

    Science.gov (United States)

    Song, Mingzhao; Iorsh, Ivan; Kapitanova, Polina; Nenasheva, Elizaveta; Belov, Pavel

    2016-01-01

    We numerically investigate a magnetic resonant wireless power transfer system based on high refractive index dielectric resonators. We propose to operate at magnetic quadrupole mode of the resonators to enlarge the efficiency due to minimization of ohmic and radiation losses. Numerical estimation predicts the 80% efficiency of the wireless power transfer (WPT) system operating at quadrupole mode at 300 MHz. Moreover, the system operating at magnetic quadrupole mode is capable of transferring power with 70% efficiency when the receiver rotates 90°. We verify the simulated results by experimental investigation of the WPT system based on microwave ceramic resonators (ɛ = 80 and tanδ = 10-4).

  3. Bose-Einstein Condensation in an electro-pneumatically transformed quadrupole-Ioffe magnetic trap

    CERN Document Server

    Kumar, Sunil; Verma, Gunjan; Vishwakarma, Chetan; Noaman, Md; Rapol, Umakant

    2014-01-01

    We report a novel approach for preparing a Bose-Einstein condensate (BEC) of $^{87}$Rb atoms using electro-pneumatically driven transfer of atoms into a Quadrupole-Ioffe magnetic trap (QUIC Trap). More than 5$\\times$$10^{8}$ atoms from a Magneto-optical trap are loaded into a spherical quadrupole trap and then these atoms are transferred into an Ioffe trap by moving the Ioffe coil towards the center of the quadrupole coil, thereby, changing the distance between quadrupole trap center and the Ioffe coil. The transfer efficiency is more than 80 \\%. This approach is different from a conventional approach of loading the atoms into a QUIC trap wherein the spherical quadrupole trap is transformed into a QUIC trap by changing the currents in the quadrupole and the Ioffe coils. The phase space density is then increased by forced rf evaporative cooling to achieve the Bose-Einstein condensation having more than $10^{5}$ atoms.

  4. Testing of Nb3Sn quadrupole coils using magnetic mirror structure

    Energy Technology Data Exchange (ETDEWEB)

    Zlobin, A.V.; Andreev, N.; Barzi, E.; Bossert, R.; Chlachidze, G.; Kashikhin, V.S.; Kashikhin, V.V.; Lamm, M.; Novitski, I.; Tartaglia, M.; Tompkins, J.C.; /Fermilab

    2009-07-01

    This paper describes the design and parameters of a quadrupole mirror structure for testing the mechanical, thermal and quench performance of single shell-type superconducting quadrupole coils at field, current and force levels similar to that of real magnet. The concept was experimentally verified by testing two quadrupole coils, previously used in quadrupole models, in the developed mirror structure in the temperature range from 4.5 to 1.9 K. The coils were instrumented with voltage taps, heaters, and strain gauges to monitor their mechanical and thermal properties and quench performance. A new quadrupole coil made of improved Nb{sub 3}Sn RRP-108/127 strand and cable insulation based on E-glass tape was also tested using this structure. The fabrication and test results of the quadrupole mirror models are reported and discussed.

  5. Testing of Nb3Sn quadrupole coils using magnetic mirror structure

    Energy Technology Data Exchange (ETDEWEB)

    Zlobin, A.V.; Andreev, N.; Barzi, E.; Bossert, R.; Chlachidze, G.; Kashikhin, V.S.; Kashikhin, V.V.; Lamm, M.; Novitski, I.; Tartaglia, M.; Tompkins, J.C.; /Fermilab

    2009-07-01

    This paper describes the design and parameters of a quadrupole mirror structure for testing the mechanical, thermal and quench performance of single shell-type superconducting quadrupole coils at field, current and force levels similar to that of real magnet. The concept was experimentally verified by testing two quadrupole coils, previously used in quadrupole models, in the developed mirror structure in the temperature range from 4.5 to 1.9 K. The coils were instrumented with voltage taps, heaters, and strain gauges to monitor their mechanical and thermal properties and quench performance. A new quadrupole coil made of improved Nb{sub 3}Sn RRP-108/127 strand and cable insulation based on E-glass tape was also tested using this structure. The fabrication and test results of the quadrupole mirror models are reported and discussed.

  6. Surface electric current distributions on spheres and spheroids as sources of pure quadrupole magnetic fields

    OpenAIRE

    L. Medina; E. Ley-Koo

    2011-01-01

    Neutral atom magnetic traps and nuclear magnetic resonance imaging require internal regions with constant gradient magnetic induction fields, which are identified as pure quadrupole fields. This contribution starts from such fields in the interior of spheres and spheroids in cartesian coordinates, identifying immediately their respective scalar magnetic potentials. Next, the corresponding potentials inside and outside are constructed using spherical and spheroidal harmonic functions, respecti...

  7. Design Challenges for a Wide-Aperture Insertion Quadrupole Magnet

    CERN Document Server

    Russenschuck, S; Perez, J C; Ramos, D; Fessia, P; Karppinen, M; Kirby, G; Sahner, T; Schwerg, N

    2011-01-01

    The design and development of a superconducting (Nb-Ti) quadrupole with 120 mm aperture, for an upgrade of the LHC insertion region, faces challenges arising from the LHC beam optics requirements and the heat-deposition. The first triggered extensive studies of coil alternatives with four and six coil-blocks in view of field quality and operation margins. The latter requires more porous insulation schemes for both the cables and the ground-plane. This in turn necessitates extensive heatpropagation and quench-velocity studies, as well as more efficient quench heaters. The engineering design of the magnet includes innovative features such as self-locking collars, which will enable the collaring to be performed with the coils on a horizontal assembly bench, a spring-loaded and collapsible assembly mandrel, tuning-shims for field quality, porous collaring-shoes, and coil end-spacer design based on differential geometry methods. The project also initiated code extensions in the quench-simulation and CAD/CAM module...

  8. Characterization of the ELIMED prototype permanent magnet quadrupole system

    Science.gov (United States)

    Russo, A. D.; Schillaci, F.; Pommarel, L.; Romano, F.; Amato, A.; Amico, A. G.; Calanna, A.; Cirrone, G. A. P.; Costa, M.; Cuttone, G.; Amato, C.; De Luca, G.; Flacco, F. A.; Gallo, G.; Giove, D.; Grmek, A.; La Rosa, G.; Leanza, R.; Maggiore, M.; Malka, V.; Milluzzo, G.; Petringa, G.; Pipek, J.; Scuderi, V.; Vauzour, B.; Zappalà, E.

    2017-01-01

    The system described in this work is meant to be a prototype of a more performing one that will be installed at ELI-Beamlines in Prague for the collection of ions produced after the interaction Laser-target, [1]. It has been realized by the researchers of INFN-LNS (Laboratori Nazionali del Sud of the Instituto Nazionale di Fisica Nucleare) and SIGMAPHI, a French company, using a system of Permanent Magnet Quadrupoles (PMQs), [2]. The final system that will be installed in Prague is designed for protons and carbons up to 60 MeV/u, around 10 times more than the energies involved in the present work. The prototype, shown in this work, has been tested in collaboration with the SAPHIR experimental facility group at LOA (Laboratoire d'Optique Appliqueé) in Paris using a 200 TW Ti:Sapphire laser system. The purpose of this work is to validate the design and the performances of this large and compact bore system and to characterize the beam produced after the interaction laser-target and its features. Moreover, the optics simulations have been compared with a real beam shape on a GAFChromic film. The procedure used during the experimental campaign and the most relevant results are reported here demonstrating a good agreement with the simulations and a good control on the beam optics.

  9. Performance of Nb3Sn quadrupole magnets under localized thermal load

    Energy Technology Data Exchange (ETDEWEB)

    Kashikhin, V.V.; Bossert, r.; Chlachidze, G.; Lamm, M.; Mokhov, N.V.; Novitski, I.; Zlobin, A.V.; /Fermilab

    2009-06-01

    This paper describes the results of design and analyses performed on 120-mm Nb{sub 3}Sn and NbTi quadrupole magnets with parameters relevant for the LHC IR upgrade. A realistic radiation heat load is evaluated in a wide luminosity range and translated into the magnet quench performance. The simulation results are supported by thermal measurements on a 90-mm Nb{sub 3}Sn quadrupole coil.

  10. Assembly of the first model of MQXFS quadrupole magnet for Hi-Lumi

    CERN Multimedia

    AUTHOR|(CDS)2086825

    2016-01-01

    Building 927. Assembly of the first model of MQXFS quadrupole magnet for Hi-Lumi. The MQXF models are about 1.5 m long and are used to validate the design before start building the first long prototype. Two types of insertion quadrupoles will be built and installed in the LHC tunnel during LS3. LARP (US collaboration) will built MQXFA type (4.2 meters long) and MQXFB magnets (around 7 m long) will be built at CERN.

  11. Performance of Nb3Sn quadrupole magnets under localized thermal load

    Energy Technology Data Exchange (ETDEWEB)

    Kashikhin, V.V.; Bossert, r.; Chlachidze, G.; Lamm, M.; Mokhov, N.V.; Novitski, I.; Zlobin, A.V.; /Fermilab

    2009-06-01

    This paper describes the results of design and analyses performed on 120-mm Nb{sub 3}Sn and NbTi quadrupole magnets with parameters relevant for the LHC IR upgrade. A realistic radiation heat load is evaluated in a wide luminosity range and translated into the magnet quench performance. The simulation results are supported by thermal measurements on a 90-mm Nb{sub 3}Sn quadrupole coil.

  12. Quenching behaviour of quadrupole model magnets for the LHC inner triplets at Fermilab

    CERN Document Server

    Andreev, N; Bauer, P; Bossert, R; Brandt, J; Chichili, D R; Carson, J; Di Marco, J; Fehér, S; Glass, H; Kerby, J S; Lamm, M J; Makarov, A A; Nobrega, A; Novitski, I; Ogitsu, T; Orris, D; Ozelis, J P; Rabehl, Roger Jon; Robotham, W; Sabbi, G L; Schlabach, P; Sylvester, C D; Strait, J B; Tartaglia, M; Tompkins, J C; Yadav, S; Zlobin, A V; Caspi, S; McInturff, A D; Scanlan, R M; Ghosh, A

    2000-01-01

    The US-LHC Accelerator Project is responsible for the design and production of inner triplet high gradient quadrupoles for installation in the LHC Interaction Region. The quadrupoles are required to deliver a nominal field gradient of 215 T/m in a 70 mm bore, and operate in superfluid helium. As part of the magnet development program, a series of 2 m model magnets have been built and tested at Fermilab, with each magnet being tested over several thermal cycles. This paper summarizes the quench performance and analysis of the model magnets tested, including quench training, and the ramp rate and temperature of the magnet quench current. (7 refs).

  13. Magnetic Sorting of the Regolith on the Moon: Lunar Swirls

    Science.gov (United States)

    Pieters, C. M.; Garrick-Bethell, I.; Hemingway, D.

    2014-12-01

    All of the mysterious albedo features on the Moon called "lunar swirls" are associated with magnetic anomalies, but not all magnetic anomalies are associated with lunar swirls [1]. It is often hypothesized that the albedo markings are tied to immature regolith on the surface, perhaps due to magnetic shielding of the solar wind and prevention of normal space weathering of the soil. Although interaction of the solar wind with the surface at swirls is indeed affected by the local magnetic field [2], this does not appear to result in immature soils on the surface. Calibrated spectra from the Moon Mineralogy Mapper [M3] (in image format) demonstrate that the high albedo markings for swirls are simply not consistent with immature regolith as is now understood from detailed analyses of lunar samples [eg 3]. However, M3 data show that the high albedo features of swirls are distinct and quite different from normal soils (in both the highlands and the mare). They allexhibit a flatter continuum across the near-infrared, but the actual band strength of ferrous minerals shows little (if any) deviation [4]. Recent analyses of magnetic field direction at swirls [5] mimic the observed albedo patterns (horizontal surface fields in bright areas, vertical surface fields in dark lanes). When coupled with the optical properties of magnetic separates of lunar soils [6] and our knowledge that the magnetic component of the soil results from space weathering [3,6], we propose a new and very simple explanation for these enigmatic albedo markings: the lunar swirls result from magnetic sorting of a well developed regolith. With time, normal gardening of the soil over a magnetic anomaly causes some of the dark magnetic component of the soil to be gradually removed from regions (high albedo areas) and accumulated in others (dark lanes). We are modeling predicted sorting rates using realistic rates of dust production. If this mechanism is tenable, only the origin of these magnetic anomalies

  14. Design and measurements of a thin quadrupole magnet for the AGS synchrotron

    Energy Technology Data Exchange (ETDEWEB)

    Tsoupas, N., E-mail: tsoupas@bnl.go [Brookhaven National Laboratory BNL, Upton, NY 11973 (United States); Alforque, R.; Jain, A.; MacKay, W.; Marneris, I. [Brookhaven National Laboratory BNL, Upton, NY 11973 (United States)

    2011-03-21

    Four quadrupoles were installed in four straight sections of the AGS synchrotron to compensate for the effect on the beam optics of two helical magnets also installed in the AGS. The overall length of each quadrupole is less than 30 cm, so it fits in the 62 cm long straight section of the AGS ring. At injection energies, the strength of each quadrupole is set at a high value, and is ramped down to zero during the acceleration cycle, as the effect of the helical magnets on the circulating beam, diminishes by the square of the beam's rigidity. To minimize the eddy currents generated in the iron core of the quadrupole, by the transient magnetic field during the ramp down time, the quadrupoles were laminated. In this paper we describe the process of designing the quadrupole, with three of the most important aspects of the design discussed below. The first was to select the maximum thickness of the iron lamination that does not affect significantly the field quality of the quadrupole during the ramp down time interval, and also reduces to an acceptable level the ohmic losses generated in the iron laminations. The second was to minimize the higher order, 12pole allowed magnetic multipole of the quadrupole. The third was to calculate the ohmic losses in the iron laminations, as a function of both the lamination thickness and the magnetic field strength. The calculated ohmic losses in the iron laminations as a function of time and lamination thickness are consistent with the time evolution of the eddy currents inside the laminations. Simple experimental measurement of the current and voltage across the coil of the magnet as a function of time, qualitatively agrees with the theoretically calculated ohmic losses in the iron laminations.

  15. Optimization of transfer of laser-cooled atom cloud to a quadrupole magnetic

    Indian Academy of Sciences (India)

    S P Ram; S K Tiwari; S R Mishra; H S Rawat

    2014-02-01

    We present here our experimental results on transfer of laser-cooled atom cloud to a quadrupole magnetic trap. We show that by choosing appropriately the ratio of potential energy in magnetic trap to kinetic energy of cloud in molasses, we can obtain the maximum phase-space density in the magnetic trap. These results guide us to choose the value of current to be switched in the quadrupole coils used for magnetic trapping for a given temperature of the cloud after molasses. This study is also useful to set the initial phase-space density of the cloud before evaporative cooling.

  16. Characterization of magnetic nanoparticles using programmed quadrupole magnetic field-flow fractionation.

    Science.gov (United States)

    Williams, P Stephen; Carpino, Francesca; Zborowski, Maciej

    2010-09-28

    Quadrupole magnetic field-flow fractionation is a relatively new technique for the separation and characterization of magnetic nanoparticles. Magnetic nanoparticles are often of composite nature having a magnetic component, which may be a very finely divided material, and a polymeric or other material coating that incorporates this magnetic material and stabilizes the particles in suspension. There may be other components such as antibodies on the surface for specific binding to biological cells, or chemotherapeutic drugs for magnetic drug delivery. Magnetic field-flow fractionation (MgFFF) has the potential for determining the distribution of the magnetic material among the particles in a given sample. MgFFF differs from most other forms of field-flow fractionation in that the magnetic field that brings about particle separation induces magnetic dipole moments in the nanoparticles, and these potentially can interact with one another and perturb the separation. This aspect is examined in the present work. Samples of magnetic nanoparticles were analysed under different experimental conditions to determine the sensitivity of the method to variation of conditions. The results are shown to be consistent and insensitive to conditions, although magnetite content appeared to be somewhat higher than expected.

  17. Characterization and tuning of ultrahigh gradient permanent magnet quadrupoles

    Directory of Open Access Journals (Sweden)

    S. Becker

    2009-10-01

    Full Text Available The application of quadrupole devices with high field gradients and small apertures requires precise control over higher order multipole field components. We present a new scheme for performance control and tuning, which allows the illumination of most of the quadrupole device aperture because of the reduction of higher order field components. Consequently, the size of the aperture can be minimized to match the beam size achieving field gradients of up to 500  T m^{-1} at good imaging quality. The characterization method based on a Hall probe measurement and a Fourier analysis was confirmed using the high quality electron beam at the Mainz Microtron MAMI.

  18. Quantum Effects on an Atom with a Magnetic Quadrupole Moment in a Region with a Time-Dependent Magnetic Field

    Science.gov (United States)

    Fonseca, I. C.; Bakke, K.

    2017-01-01

    The quantum description of an atom with a magnetic quadrupole moment in the presence of a time-dependent magnetic field is analysed. It is shown that the time-dependent magnetic field induces an electric field that interacts with the magnetic quadrupole moment of the atom and gives rise to a Landau-type quantization. It is also shown that a time-independent Schrödinger equation can be obtained, i.e., without existing the interaction between the magnetic quadrupole moment of the atom and the time-dependent magnetic field, therefore, the Schrödinger equation can be solved exactly. It is also analysed this system subject to scalar potentials.

  19. Design and fabrication of the first quadrupole magnet for the ILSF storage ring

    Directory of Open Access Journals (Sweden)

    F Saeidi

    2015-09-01

    Full Text Available The Iranian Light Source Facility (ILSF is a new 3 GeV third generation synchrotron light source which is consisted of several pre-accelerators and a storage ring with the beam current of 400 mA. Based on the main lattice candidate, the storage ring includes of 100 dipoles, 320 quadrupoles and 320 sextupole magnets. To develop fabrication procedures and techniques and to compare the measurement results with the design data, a series of lattice magnets have been fabricated inside Iran with internal industries. In this article the first prototype quadrupole magnet fabrication process has been described

  20. Magnetic activated cell sorting (MACS): utility in assisted reproduction.

    Science.gov (United States)

    Makker, Kartikeya; Agarwal, Ashok; Sharma, Rakesh K

    2008-07-01

    Assisted reproductive techniques (ART) have now been extensively incorporated in the management of infertile couples. But even after rapid methodological and technological advances the success rates of these procedures have been below expectations. This has led to development of many sperm preparation protocols to obtain an ideal semen sample for artificial reproduction. Sperm apoptosis has been heavily linked to failures in reproductive techniques. One of the earliest changes shown by apoptotic spermatozoa is externalization of phosphatidyl serine. Magnetic activated cell sorting (MACS) is a novel sperm preparation technique that separates apoptotic and non-apoptotic spermatozoa based on the expression of phosphatidylserine. This has led to the incorporation of MACS as a sperm preparation technique. The review highlights the principle and mechanism of this novel technique and enumerates its advantages as a sperm preparation technique. Its utility in ART as an efficient tool for sperm recovery and its application in cryopreservation of semen samples is also explained.

  1. Magnetic cell sorting and flow cytometry sorting methods for the isolation and function analysis of mouse CD4+ CD25+ Treg cells*

    OpenAIRE

    2009-01-01

    Objective: In this paper we compared the two methods of cell sorting (magnetic cell sorting and flow cytometry sorting) for the isolation and function analysis of mouse CD4+ CD25+ regulatory T (Treg) cells, in order to inform further studies in Treg cell function. Methods: We separately used magnetic cell sorting and flow cytometry sorting to identify CD4+ CD25+ Treg cells. After magnetic cell separation, we further used flow cytometry to analyze the purity of CD4+ CD25+ Treg cells, trypan bl...

  2. Magnet Design of the 150 mm Aperture Low-β Quadrupoles for the High Luminosity LHC

    CERN Document Server

    Ferracin, P; Anerella, M; Borgnolutti, F; Bossert, R; Cheng, D; Dietderich, D R; Felice, H; Ghosh , A; Godeke, A; Izquierdo Bermudez, S; Fessia, P; Krave, S; Juchno, M; Perez, J C; Oberli, L; Sabbi, G; Todesco, E; Yu, M

    2014-01-01

    The High Luminosity LHC (HL-LHC) project is aimed at studying and implementing the necessary changes in the LHC to increase its luminosity by a factor five. Among the magnets that will be upgraded are the 16 superconducting low-β quadrupoles placed around the two high luminosity interaction regions (ATLAS and CMS experiments). In the current baseline scenario, these quadrupole magnets will have to generate a gradient of 140 T/m in a coil aperture of 150 mm. The resulting conductor peak field of more than 12 T will require the use of Nb3Sn superconducting coils. We present in this paper the HL-LHC low-β quadrupole design, based on the experience gathered by the US LARP program, and, in particular, we describe the support structure components to pre-load the coils, withstand the electro-magnetic forces, provide alignment and LHe containment, and integrate the cold mass in the LHC IRs.

  3. The LHC's future, part 1: The High-Luminosity quadrupole magnet

    CERN Multimedia

    2017-01-01

    Increasing the number of collisions by a factor of 10 is a future goal for the Large Hadron Collider. To do this, the High-Luminosity Large Hadron Collider (HL-LHC) project is working on cranking up LHC performance to increase discovery potential after 2025. Among the components to be upgraded are the quadrupole magnets in interaction points IP1 and IP5, which will use a new superconducting technology based on the superconductor Niobium-tin (Nb3Sn). This superconductor will help reach magnetic fields of about 12 T, but it requires a complex fabrication process that includes heat treatment of the coils to about 650 degrees Celsius and vacuum impregnation with epoxy. In CERN's superconducting model magnets laboratory the Magnet, Superconductors and Cryostats group is currently fabricating short models of the final Nb3Sn HL-LHC quadrupole magnet to verify the magnet design and define fabrication and assembly procedures.

  4. Competition between Quadrupole and Magnetic Kondo Effects in Non-Kramers Doublet Systems

    Science.gov (United States)

    Kusunose, Hiroaki; Onimaru, Takahiro

    2015-03-01

    We discuss possible competition between magnetic and quadrupole Kondo effects in non-Kramers doublet systems in cubic symmetry. The quadrupole Kondo effect leads to non-Fermi-liquid (NFL) ground state, while the magnetic one favors ordinary Fermi-liquid (FL) ground state. In terms of the j-j coupling scheme, we argue that the orbital fluctuation must develop in the vicinity of the NFL-FL boundary. A change of temperature dependence of the f-electron entropy in both the FL and NFL regimes is demonstrated by the Wilson's numerical renormalization-group (NRG) method on the basis of the extended two-channel Kondo exchange model. We present implications to PrT2X20 (T=Ti, V, Ir; X=Al, Zn) systems which exhibit both quadrupole ordering and peculiar superconductivity. We discuss how the magnetic field lifts the non-Kramers degeneracy. Our model also represents the alternative FL state accompanied by a free magnetic spin, as a consequence of stronger competition between the magnetic and the quadrupole Kondo effects.

  5. Magnetic Measurements of Permanent and Fast-Pulsed Quadrupoles for the CERN LINAC4 Project

    CERN Document Server

    Golluccio, G; Buzio, M; Dunkel, O; Giloteaux, D; Lombardi, A; Mateo, F; Ramberger, S

    2010-01-01

    Linac4 is currently under construction at CERN to improve intensity and reliability for the whole accelerator chain. This machine will include about 120 permanent quadrupoles housed in the Drift Tube tanks, as well as about 80 electromagnetic quadrupoles. This paper describes the magnetic measurements carried out at CERN on the first batch of quadrupoles, including several prototypes from different manufacturers, as well as those done on several spare Linac 2 magnets reused in Linac4's 3 MeV test stand. We first describe a prototype test bench based on technology developed for the LHC and able to carry out high-precision harmonic measurements in both continuously-rotating and stepping-coil mode. Next we present the first results obtained in terms of field strength, harmonics quality and effects of fast eddy current transients. Finally, we discuss the expected impact of these findings on the operation of the machine.

  6. Thermal studies of a high gradient quadrupole magnet cooled with pressurized, stagnant superfluid

    CERN Document Server

    Chiesa, L; Kerby, J S; Lamm, M J; Novitski, I; Orris, D; Ozelis, J P; Peterson, Thomas J; Tartaglia, M; Zlobin, A V

    2001-01-01

    A 2-m long superconducting model of an LHC Interaction Region quadrupole magnet was wound with stabrite coated cable. The resulting low interstrand resistance and high AC losses presented the opportunity to measure magnet quench performance in superfluid as a function of helium temperature and heat deposition in the coil. Our motivation was to duplicate the high radiation heat loads predicted for the inner triplet quadrupoles at LHC and study the coil cooling conditions in the magnet. At the Magnet Test Facility in Fermilab's Technical Division, the magnet quench performance was tested as a function of bulk helium temperature and current ramp rate near the planned high luminosity interaction region field gradient of 205 T/m. AC loss measurements provided a correlation between current ramp rate and heat deposition in the coil. Analysis indicates that the results are consistent with there being little participation of superfluid helium in the small channels inside the inner layer in the heat removal from the co...

  7. Cryogenic performance of a conduction-cooling splittable quadrupole magnet for ILC cryomodules

    Energy Technology Data Exchange (ETDEWEB)

    Kimura, N.; Yamamoto, A. [High Energy Accelerator Research Organization (KEK), 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan); Andreev, N.; Kashikhin, V. S.; Tartaglia, M. A. [Fermi National Accelerator Laboratory, P.O. Box 500, Batavia, IL 60510 (United States); Kerby, J. [Argonne National Laboratory, Argonne, 9700 S. Cass Avenue, IL 60439 (United States); Takahashi, M.; Tosaka, T. [Toshiba Corporation Power Systems Company, 2-4 Suehiro-Cho, Tsurumi-Ku, Yokohama, Kanagawa 230-0045 (Japan)

    2014-01-29

    A conduction-cooled splittable superconducting quadrupole magnet was designed and fabricated at Fermilab for use in cryomodules of the International Linear Collider (ILC) type, in which the magnet was to be assembled around the beam tube to avoid contaminating the ultraclean superconducting radio frequency cavity volume. This quadrupole was first tested in a liquid helium bath environment at Fermilab, where its quench and magnetic properties were characterized. Because the device is to be cooled by conduction when installed in cryomodules, a separate test with a conduction-cooled configuration was planned at KEK and Fermilab. The magnet was converted to a conduction-cooled configuration by adding conduction-cooling passages made of high-purity aluminum. Efforts to convert and refabricate the magnet into a cryostat equipped with a double-stage pulse-tube-type cryocooler began in 2011, and a thermal performance test, including a magnet excitation test of up to 30 A, was conducted at KEK. In this test, the magnet with the conduction-cooled configuration was successfully cooled to 4 K within 190 h, with an acceptable heat load of less than 1 W at 4 K. It was also confirmed that the conduction-cooled splittable superconducting quadrupole magnet was practical for use in ILC-type cryomodules.

  8. Cryogenic performance of a conduction-cooling splittable quadrupole magnet for ILC cryomodules

    Science.gov (United States)

    Kimura, N.; Andreev, N.; Kashikhin, V. S.; Kerby, J.; Takahashi, M.; Tartaglia, M. A.; Tosaka, T.; Yamamoto, A.

    2014-01-01

    A conduction-cooled splittable superconducting quadrupole magnet was designed and fabricated at Fermilab for use in cryomodules of the International Linear Collider (ILC) type, in which the magnet was to be assembled around the beam tube to avoid contaminating the ultraclean superconducting radio frequency cavity volume. This quadrupole was first tested in a liquid helium bath environment at Fermilab, where its quench and magnetic properties were characterized. Because the device is to be cooled by conduction when installed in cryomodules, a separate test with a conduction-cooled configuration was planned at KEK and Fermilab. The magnet was converted to a conduction-cooled configuration by adding conduction-cooling passages made of high-purity aluminum. Efforts to convert and refabricate the magnet into a cryostat equipped with a double-stage pulse-tube-type cryocooler began in 2011, and a thermal performance test, including a magnet excitation test of up to 30 A, was conducted at KEK. In this test, the magnet with the conduction-cooled configuration was successfully cooled to 4 K within 190 h, with an acceptable heat load of less than 1 W at 4 K. It was also confirmed that the conduction-cooled splittable superconducting quadrupole magnet was practical for use in ILC-type cryomodules.

  9. Accurate measurements of electric quadrupole hyperfine interactions of very dilute spins in magnetic solids

    Science.gov (United States)

    Chaplin, D. H.; Hutchison, W. D.; Prandolini, M. J.; Bowden, G. J.

    1998-01-01

    The application of double and triple resonance techniques to enhance signals in quadrupole interaction — nuclear magnetic resonance on oriented nuclei spectroscopy, is illustrated for the antiferromagnet ( 54Mn)MnBr 2-4H 2O. Unusual shifts of the quadrupolar split, higher order, ν ±2, ±1 subresonance, comparable to the NMRON linewidth, are observed and explained.

  10. Simulation and Field Measurement of Quadrupole Magnets for KOMAC 20MeV Beam line

    Energy Technology Data Exchange (ETDEWEB)

    Chung, B. H.; Kim, H. S.; Song, Y. G.; Kwon, H. J.; Cho, Y. S. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    In this paper, quadrupole magnets the same as installed at the beam line simulated and analyzed for magnetic fields. Also quadrupole magnets will be measured field stability and evaluated reliability on long time operation. Control system consisted of Labview program and communication method consisted of Ethernet and Rs-232 with optical fiber for devices safety from high voltage and/or high current. As a results the DC power supply is controlled, magnetic fields data is acquired and coil temperature is measured. Magnetic field with hall sensor and temperature with K-type thermo-couple are measured with conversion factor using by voltmeter. Korea Multi-purpose Accelerator Complex (KOMAC) was developed at Gyeongju in Korea in 2012. KOMAC including a 50-keV ion source, a 3-MeV RFQ, and a 100-MeV DTL. And beam line consists of 20-MeV and 100-MeV for user. Proton beam transferred from the linac to the beam line using by dipole magnets and transferred proton beam focused and decreased beam loss and by quadrupole magnets.

  11. Finite Element Model of Training in the superconducting quadrupole magnet SQ02

    Energy Technology Data Exchange (ETDEWEB)

    Caspi, Shlomo; Ferracin, Paolo

    2007-11-01

    This paper describes the use of 3D finite element models to study training in superconducting magnets. The simulations are used to examine coil displacements when the electromagnetic forces are cycled, and compute the frictional energy released during conductor motion with the resulting temperature rise. A computed training curve is then presented and discussed. The results from the numerical computations are compared with test results of the Nb{sub 3}Sn racetrack quadrupole magnet SQ02.

  12. Stabilization and positioning of CLIC quadrupole magnets with sub-nanometre resolution

    CERN Document Server

    Janssens, S; Collette, C; Esposito, M; Fernandez Carmona, P; Guinchard, M; Hauviller, C; Kuzmin, A; Leuxe, R; Moron Ballester, R

    2011-01-01

    To reach the required luminosity at the CLIC interaction point, about 2000 quadrupoles along each linear collider are needed to obtain a vertical beam size of 1 nm at the interaction point. Active mechanical stabilization is required to limit the vibrations of the magnetic axis to the nanometre level in a frequency range from 1 to 100 Hz. The approach of a stiff actuator support was chosen to isolate from ground motion and technical vibrations acting directly on the quadrupoles. The actuators can also reposition the quadrupoles between beam pulses with nanometre resolution. A first conceptual design of the active stabilization and nano positioning based on the stiff support and seismometers was validated in models and experimentally demonstrated on test benches. Lessons learnt from the test benches and information from integrated luminosity simulations using measured stabilization transfer functions lead to improvements of the actuating support, the sensors used and the system controller. The controller elect...

  13. Integrated design of superconducting accelerator magnets a case study of the main quadrupole

    CERN Document Server

    Russenschuck, Stephan; Lewin, M; Paul, C; Ramberger, S; Rodríguez-Mateos, F; Tortschanoff, Theodor; Verweij, A P; Wolf, R

    1998-01-01

    This paper describes the software tool which has been developed for the design of the superconducting magnets for the Large Hadron Collider (LHC) at CERN. Applied methods include numerical field calculation with a reduced vector-potential formulation, the application of vector-optimization methods, and the use of genetic as well as deterministic minimization algorithms. Together with the applied concept of features, the software tool is used as an approach towards integrated design of superconducting magnets. The main quadrupole magnet for the LHC, which was designed at C.E.A. Saclay (France) using a different approach, was chosen as an example for the integrated design process. The paper focuses on the design issues and is not a project report on the main quadrupoles under construction.

  14. Spin, quadrupole moment, and deformation of the magnetic-rotational band head in (193)Pb

    CERN Document Server

    Balabanski, D L; Iordachescu, A; Bazzacco, D; Brandolini, F; Bucurescu, D; Chmel, S; Danchev, M; De Poli, M; Georgiev, G; Haas, H; Hubel, H; Marginean, N; Menegazzo, R; Neyens, G; Pavan, P; Rossi Alvarez, C; Ur, C A; Vyvey, K; Frauendorf, S

    2011-01-01

    The spectroscopic quadrupole moment of the T(1/2) = 9.4(5) ns isomer in (193)Pb at an excitation energy E(ex) = (2585 + x) keV is measured by the time-differential perturbed angular distribution method as vertical bar Q(s)vertical bar = 2.6(3) e b. Spin and parity I(pi) = 27/2(-) are assigned to it based on angular distribution measurements. This state is the band head of a magnetic-rotational band, described by the coupling of a neutron hole in the 1i(13/2) subshell with the (3s(1/2)(-2)1h(9/2)1i(13/2))(11-) proton excitation. The pairing-plus-quadrupole tilted-axis cranking calculations reproduce the measured quadrupole moment with a moderate oblate deformation epsilon(2) = -0.11, similar to that of the 11(-)proton intruder states, which occur in the even-even Pb nuclei in the region. This is the first direct measurement of a quadrupole moment and thus of the deformation of a magnetic-rotational band head.

  15. Electron Cloud Generation and Trapping in a Quadrupole Magnet at the Los Alamos Proton Storage Ring

    Energy Technology Data Exchange (ETDEWEB)

    Macek, Robert J.; Browman, Andrew A.; Ledford, John E.; /TechSource, Santa Fe /Los Alamos; Borden, Michael J.; O' Hara, James F.; McCrady, Rodney C.; Rybarcyk, Lawrence J.; Spickermann, Thomas; Zaugg, Thomas J.; /Los Alamos; Pivi, Mauro T.F.; /SLAC

    2008-03-17

    Recent beam physics studies on the two-stream e-p instability at the LANL proton storage ring (PSR) have focused on the role of the electron cloud generated in quadrupole magnets where primary electrons, which seed beam-induced multipacting, are expected to be largest due to grazing angle losses from the beam halo. A new diagnostic to measure electron cloud formation and trapping in a quadrupole magnet has been developed, installed, and successfully tested at PSR. Beam studies using this diagnostic show that the 'prompt' electron flux striking the wall in a quadrupole is comparable to the prompt signal in the adjacent drift space. In addition, the 'swept' electron signal, obtained using the sweeping feature of the diagnostic after the beam was extracted from the ring, was larger than expected and decayed slowly with an exponential time constant of 50 to 100 {micro}s. Other measurements include the cumulative energy spectra of prompt electrons and the variation of both prompt and swept electron signals with beam intensity. Experimental results were also obtained which suggest that a good fraction of the electrons observed in the adjacent drift space for the typical beam conditions in the 2006 run cycle were seeded by electrons ejected from the quadrupole.

  16. Training characteristics of 1-m model magnets for the LHC low-beta quadrupoles

    CERN Document Server

    Nakamoto, T; Tsuchiya, K; Ajima, Y; Burkhardt, E E; Haruyama, T; Higashi, N; Iida, M; Kimura, N; Ogitsu, T; Ohhata, I; Ohuchi, N; Shintomi, T; Tanaka, K; Terashima, A

    2000-01-01

    Two models of the high gradient 70 mm aperture superconducting low- beta quadrupole magnets were developed at KEK as part of the collaboration between CERN and KEK for the Large Hadron Collider (LHC). The training tests of both model magnets have been carried out at 1.9 K and both models successfully reached the design field gradient of 240 T/m, and the training memory partially remained after thermal cycles. General characteristics of the training curve for the models seemed to be similar. In this paper, training results of the model magnets is described and discussed. (12 refs).

  17. Tests results of Nb$_{3}$Sn quadrupole magnets using a shell-based support structure

    CERN Document Server

    Caspi, S

    2009-01-01

    In support of the development of a 90 mm aperture Nb3Sn superconducting quadrupole for the US LHC Accelerator Research Program (LARP), test results of five quadrupole magnets are compared. All five assemblies used key and bladder technology to compress and support the coils within an iron yoke and an aluminium shell. The first three models (TQS01a, b, c) used Nb3Sn MJR conductor and segmented bronze poles. The last two models (TQS02a, b) used Nb3Sn RRP conductor, and segmented titanium alloy (TiAl6V4) poles, with no axial gaps during reaction. This presentation summarizes the magnets performance during assembly, cool-down and excitation and compares measurements with design expectations.

  18. Production of rubidium Bose-Einstein condensate in an optically-plugged magnetic quadrupole trap

    CERN Document Server

    Zhang, Dong-Fang; Kong, Ling-Ran; Li, Kai; Jiang, Kai-Jun

    2016-01-01

    We have experimentally produced rubidium Bose-Einstein condensate in an optically-plugged magnetic quadrupole (OPQ) trap. A far blue-detuned focused laser beam with a wavelength of 532 nm is plugged in the center of the magnetic quadrupole trap to increase the number of trapped atoms and suppress the heating. A radio frequency (RF) evaporative cooling in the magneto-optical hybrid trap is applied to decrease the atom temperature into degeneracy. The atom number of the condensate is $1.2(0.4)\\times10^5$ and the temperature is below 100 nK. We have also studied characteristic behaviors of the condensate, such as phase space density (PSD), condensate fraction and anisotropic expansion.

  19. Rotating effects on the Landau quantization for an atom with a magnetic quadrupole moment

    Energy Technology Data Exchange (ETDEWEB)

    Fonseca, I. C.; Bakke, K., E-mail: kbakke@fisica.ufpb.br [Departamento de Física, Universidade Federal da Paraíba, Caixa Postal 5008, João Pessoa, PB 58051-970 (Brazil)

    2016-01-07

    Based on the single particle approximation [Dmitriev et al., Phys. Rev. C 50, 2358 (1994) and C.-C. Chen, Phys. Rev. A 51, 2611 (1995)], the Landau quantization associated with an atom with a magnetic quadrupole moment is introduced, and then, rotating effects on this analogue of the Landau quantization is investigated. It is shown that rotating effects can modify the cyclotron frequency and breaks the degeneracy of the analogue of the Landau levels.

  20. B&W Vertical Test Facility for SSC collider quadrupole magnets

    Energy Technology Data Exchange (ETDEWEB)

    Dixon, K.D.; Billingsly, A.L.; Boyes, D.W.; Cantor, B.I.; Hlasnicek, P.; Kelley, J.P.; Leamon, C.K.; Maloney, J.E.; Pare, G.; Rey, C.M. [Babcock & Wilcox, Lynchburg, VA (United States)] [and others

    1994-12-31

    Developmental or {open_quotes}model{close_quotes} SSC quadrupole cold masses and collared coils are successfully being tested at the Vertical Test Facility (VTF) in Lynchburg, Virginia. Within this facility, a vertical dewar maintains a pool boiling liquid helium environment of 3.85 K to 4.5 K in order to observe the quenching and magnetic field characteristics of these coils. A description of the facility performance and its contents, including the dewar and ancillary equipment, is described hereafter.

  1. Rotating effects on the Landau quantization for an atom with a magnetic quadrupole moment

    CERN Document Server

    Fonseca, I C

    2016-01-01

    Based on the single particle approximation [V. F. Dmitriev {\\it et al}, Phys. Rev. C {\\bf50}, 2358 (1994), C.-C. Chen, Phys. Rev. A {\\bf51}, 2611 (1995)], the Landau quantization associated with an atom with a magnetic quadrupole moment is introduced, and then, rotating effects on this analogue of the Landau quantization is investigated. It is shown that rotating effects can modify the cyclotron frequency and breaks the degeneracy of the analogue of the Landau levels.

  2. Rotating effects on the Landau quantization for an atom with a magnetic quadrupole moment.

    Science.gov (United States)

    Fonseca, I C; Bakke, K

    2016-01-07

    Based on the single particle approximation [Dmitriev et al., Phys. Rev. C 50, 2358 (1994) and C.-C. Chen, Phys. Rev. A 51, 2611 (1995)], the Landau quantization associated with an atom with a magnetic quadrupole moment is introduced, and then, rotating effects on this analogue of the Landau quantization is investigated. It is shown that rotating effects can modify the cyclotron frequency and breaks the degeneracy of the analogue of the Landau levels.

  3. Development of a large aperture Nb$_{3}$ Sn racetrack quadrupole magnet

    CERN Document Server

    Ferracin, Paolo; Caspi, Shlomo; Dietderich, D R; Gourlay, Stephen A; Hafalia, Aurelio R; Hannaford, C R; Lietzke, A F; Mattafirri, Sara; McInturff, A D; Nyman, M A; Sabbi, Gianluca

    2005-01-01

    The U.S. LHC Accelerator Research Program (LARP), a collaboration between BNL, FNAL, LBNL, and SLAC, has among its major objectives the development of advanced magnet technology for an LHC luminosity upgrade. The LBNL Superconducting Magnet Group supports this program with a broad effort involving design studies, Nb/sub 3/Sn conductor development, mechanical models, and basic prototypes. This paper describes the development of a large aperture Nb/sub 3/Sn racetrack quadrupole magnet using four racetrack coils from the LBNL Subscale Magnet (SM) Program. The magnet provides a gradient of 95 T/m in a 110 mm bore, with a peak field in the conductor of 11.2 T. The coils are pre-stressed by a mechanical structure based on a pre-tensioned aluminum shell, and axially supported with aluminum rods. The mechanical behavior has been monitored with strain gauges and the magnetic field has been measured. Results of the test are reported and analyzed.

  4. Resolution limit of probe-forming systems with magnetic quadrupole lens triplets and quadruplets

    CERN Document Server

    Ponomarev, A G; Miroshnichenko, V I; Storizhko, V E; Sulkio-Cleff, B

    2003-01-01

    Over the past decade, in MeV ion beam microanalysis efforts to achieve a spatial resolution better than 0.1 mu m with a beam current of approx 100 pA have been connected with microprobes of new generation where the probe is formed by means of separated magnetic quadrupole lens structures . However, as was pointed out in , no dramatic improvements in spatial resolution have been produced so far. For better understanding of the situation the authors carried out theoretical studies of multiparameter sets of probe-forming systems based on separated triplets and quadruplets of magnetic quadrupole lenses. Comparisons were made between the highest current values attained at different systems for a given beam spot size. The maximum parasitic sextupole and octupole field components were found whose contributions to spot broadening are tolerable. It is shown that the use of modern electrostatic accelerators and precision magnetic quadrupole lenses makes it possible to eliminate the effect of chromatic aberrations and s...

  5. Transient electromagnetic simulation and thermal analysis of the DC-biased AC quadrupole magnet for CSNS/RCS

    Institute of Scientific and Technical Information of China (English)

    SUN Xian-Jing; DENG Chang-Dong; KANG Wen

    2012-01-01

    Due to the large cddy currents at the ends of the quadrupole magnets for CSNS/RCS,the magnetic field properties and the heat generation are of great concern.In this paper,we take transient electromagnetic simulation and make use of the eddy current loss from the transient electromagnetic results to perform thermal analysis.Through analysis of the simulated results,the magnetic field dynamic properties of these magnets and a temperature rise are achieved.Finally,the accuracy of the thermal analysis is confirmed by a test of the prototype quadrupole magnet of the RCS.

  6. Capacitor-based detection of nuclear magnetization: nuclear quadrupole resonance of surfaces.

    Science.gov (United States)

    Gregorovič, Alan; Apih, Tomaž; Kvasić, Ivan; Lužnik, Janko; Pirnat, Janez; Trontelj, Zvonko; Strle, Drago; Muševič, Igor

    2011-03-01

    We demonstrate excitation and detection of nuclear magnetization in a nuclear quadrupole resonance (NQR) experiment with a parallel plate capacitor, where the sample is located between the two capacitor plates and not in a coil as usually. While the sensitivity of this capacitor-based detection is found lower compared to an optimal coil-based detection of the same amount of sample, it becomes comparable in the case of very thin samples and even advantageous in the proximity of conducting bodies. This capacitor-based setup may find its application in acquisition of NQR signals from the surface layers on conducting bodies or in a portable tightly integrated nuclear magnetic resonance sensor.

  7. Quench performance of Fermilab model magnets for the LHC inner triplet quadrupoles

    CERN Document Server

    Andreev, N; Bauer, P; Bossert, R; Brandt, J; Carson, J; Caspi, S; Chichili, D R; Chiesa, L; Di Marco, J; Fehér, S; Ghosh, A; Glass, H; Kerby, J S; Lamm, M J; Makarov, A; McInturff, A D; Nobrega, A; Novitski, I; Ogitsu, T; Orris, D; Ozelis, J P; Peterson, T; Rabehl, Roger Jon; Robotham, W; Scanlan, R M; Schlabach, P; Sylvester, C D; Strait, J B; Tartaglia, M; Tompkins, J C; Velev, G V; Yadev, S; Zlobin, A V

    2001-01-01

    As part of the US LHC program to develop high gradient superconducting quadrupoles for the LHC interaction regions, a series of 2 meter long model magnets has been built and tested at Fermilab. This R&D program was used to refine the mechanical and magnetic design, optimize fabrication and assembly tooling and ensure adequate quench performance. The final design, fabrication, and assembly procedures developed in this program have produced magnets which meet the LHC requirements of operating at 215 T/m with excellent magnetic field harmonics. This paper summarizes the test results of the last five model magnets, including quench tests over several thermal cycles, and excitation current ramp rate and temperature dependence studies. (8 refs).

  8. Experiments on the margin of beam induced quenches a superconducting quadrupole magnet in the LHC

    CERN Document Server

    Bracco, C; Bednarek, M J; Nebot Del Busto, E; Goddard, B; Holzer, E B; Nordt, A; Sapinski, M; Schmidt, R; Solfaroli Camillocci, M; Zerlauth, M

    2012-01-01

    Protection of LHC equipment relies on a complex system of collimators to capture injected and circulating beam in case of LHC kicker magnet failures. However, for specific failures of the injection kickers, the beam can graze the injection protection collimators and induce quenches of downstream superconducting magnets. This occurred twice during 2011 operation and cannot be excluded during future operation. Tests were performed during Machine Development periods of the LHC to assess the quench margin of the quadrupole located just downstream of the last injection protection collimator in point 8. In addition to the existing Quench Protection System, a special monitoring instrumentation was installed at this magnet to detect any resistance increase below the quench limit. The correlation between the magnet and Beam Loss Monitor signals was analysed for different beam intensities and magnet currents. The results of the experiments are presented.

  9. Stabilisation and precision pointing quadrupole magnets in the Compact Linear Collider (CLIC)

    CERN Document Server

    Janssens, Stef; van den Brand, Jo; Bertolini, Alessandro; Artoos, Kurt

    This thesis describes the research done to provide stabilisation and precision positioning for the main beam quadrupole magnets of the Compact Linear Collider CLIC. The introduction describes why new particle accelerators are needed to further the knowledge of our universe and why they are linear. A proposed future accelerator is the Compact Linear Collider (CLIC) which consists of a novel two beam accelerator concept. Due to its linearity and subsequent single pass at the interaction point, this new accelerator requires a very small beam size at the interaction point, in order to increase collision effectiveness. One of the technological challenges, to obtain these small beam sizes at the interaction point, is to keep the quadrupole magnets aligned and stable to 1.5 nm integrated r.m.s. in vertical and 5 nm integrated root mean square (r.m.s.) in lateral direction. Additionally there is a proposal to create an intentional offset (max. 50 nm every 20 ms with a precision of +/- 1 nm), for several quadrupole ma...

  10. Radiation of Magnetic Dipole and Electric Quadrupole in Anisotropic Medium (Ⅱ) — Rading Electric Field

    Institute of Scientific and Technical Information of China (English)

    HONGQingquan; CHENShennian; WANGJiancheng

    2003-01-01

    Taking advantage of magnetic field ra-diated by magnetic dipole and electric quadrupole in anisotropic magnetic medium which had been calculated already, the authors go further to calculate radiating elec-tric field and to confirm the correctness of results.

  11. Permanent magnet quadrupole for the 1-ST tank of LINAC-4

    CERN Document Server

    Skachkov, Vl; Sergeeva, O; Lombardi, A; Sargsyan, E; Cornuet, D; Venturini , W; Skachkov , V

    2006-01-01

    A rare-earth (REPM) ∅ 60 mm diameter, 45 mm long quadrupole for the LINAC-4 focusing channel with an integrated gradient of 2.3 T is described. Thin side washers are used for tuning the quad into specified gradient integral with ±0.5 % accuracy. The single washer contribution calculations are discussed. A method for limiting to 30 μ m the magnetic axis offset in the REPM quad is discussed to exclude its compensation by the outer diameter machining before inserting into the drift tube. Nonlinearity of the field is less than 1 % in the reference range of 75 % of beam aperture at the central cross- section near the quad axis . The angular quadrupole arrangement in the drift tube will be provided by machining the main groove on the quad surface in the median plane with 1 mrad accuracy. Calculations of the longitudinal gradient distribution between two...

  12. The Study of Single Nb3Sn Quadrupole Coils Using a Magnetic Mirror Structure

    Energy Technology Data Exchange (ETDEWEB)

    Chlachidze, G.; Andreev, N.; Barzi, E.; Bossert, R.; Kashikhin, V.S.; Kashikhin, V.V.; Lamm, M.J.; Nobrega, N.; Novitski, I.; Orris, D.; Tartaglia, M.

    2010-07-30

    Several 90-mm quadrupole coils made of 0.7-mm Nb{sub 3}Sn strand based on the 'Restack Rod Process' (RRP) of 108/127 design, with cored and non-cored cables and different cable insulation, were fabricated and individually tested at Fermilab using a test structure designed to provide a quadrupole magnetic field environment. The coils were instrumented with voltage taps and strain gauges to study quench performance and mechanical properties. The Nb{sub 3}Sn strand and cable parameters, the coil fabrication details, the mirror model assembly procedure and test results at temperatures of 4.5 K and 1.9 K are reported and discussed.

  13. The Study of Single Nb3Sn Quadrupole Coils Using a Magnetic Mirror Structure

    Energy Technology Data Exchange (ETDEWEB)

    Chlachidze, G.; Andreev, N.; Barzi, E.; Bossert, R.; Kashikhin, V.S.; Kashikhin, V.V.; Lamm, M.J.; Nobrega, N.; Novitski, I.; Orris, D.; Tartaglia, M.

    2010-07-30

    Several 90-mm quadrupole coils made of 0.7-mm Nb{sub 3}Sn strand based on the 'Restack Rod Process' (RRP) of 108/127 design, with cored and non-cored cables and different cable insulation, were fabricated and individually tested at Fermilab using a test structure designed to provide a quadrupole magnetic field environment. The coils were instrumented with voltage taps and strain gauges to study quench performance and mechanical properties. The Nb{sub 3}Sn strand and cable parameters, the coil fabrication details, the mirror model assembly procedure and test results at temperatures of 4.5 K and 1.9 K are reported and discussed.

  14. Magnetic Analysis of the Nb$_3$Sn low-beta Quadrupole for the High Luminosity LHC

    CERN Document Server

    Izquierdo Bermudez, S; Chlachidze, G; Ferracin, P; Holik, E; Di Marco, J; Todesco, E; Sabbi, G L; Vallone, G; Wang, X

    2017-01-01

    As part of the Large Hadron Collider Luminosity upgrade (HiLumi-LHC) program, the US LARP collaboration and CERN are working together to design and build 150 mm aperture $Nb_3Sn$ quadrupoles for the LHC interaction regions. A first series of 1.5 m long coils were fabricated, assembled and tested in the first short model. This paper presents the magnetic analysis, comparing magnetic field measurements with the expectations and the field quality requirements. The analysis is focused on the geometrical harmonics, iron saturation effect and cold-warm correlation. Three dimensional effects such as the variability of the field harmonics along the magnet axis and the contribution of the coil ends are also discussed. Moreover, we present the influence of the conductor magnetization and the dynamic effects.

  15. Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres

    Science.gov (United States)

    Kraus, Jr., Robert H.; Zhou, Feng; Nolan, John P

    2007-06-19

    The present invention is directed to processes of separating, analyzing and/or collecting selected species within a target sample by use of magnetic microspheres including magnetic particles, the magnetic microspheres adapted for attachment to a receptor agent that can subsequently bind to selected species within the target sample. The magnetic microspheres can be sorted into a number of distinct populations, each population with a specific range of magnetic moments and different receptor agents can be attached to each distinct population of magnetic microsphere.

  16. DC superconducting quantum interference device usable in nuclear quadrupole resonance and zero field nuclear magnetic spectrometers

    Energy Technology Data Exchange (ETDEWEB)

    Fan, Non Q. (San Diego, CA); Clarke, John (Berkeley, CA)

    1993-01-01

    A spectrometer for measuring the nuclear quadrupole resonance spectra or the zero-field nuclear magnetic resonance spectra generated by a sample is disclosed. The spectrometer uses an amplifier having a dc SQUID operating in a flux-locked loop for generating an amplified output as a function of the intensity of the signal generated by the sample. The flux-locked loop circuit includes an integrator. The amplifier also includes means for preventing the integrator from being driven into saturation. As a result, the time for the flux-locked loop to recover from the excitation pulses generated by the spectrometer is reduced.

  17. DC superconducting quantum interference device usable in nuclear quadrupole resonance and zero field nuclear magnetic spectrometers

    Energy Technology Data Exchange (ETDEWEB)

    Fan, N.Q.; Clarke, J.

    1993-10-19

    A spectrometer for measuring the nuclear quadrupole resonance spectra or the zero-field nuclear magnetic resonance spectra generated by a sample is disclosed. The spectrometer uses an amplifier having a dc SQUID operating in a flux-locked loop for generating an amplified output as a function of the intensity of the signal generated by the sample. The flux-locked loop circuit includes an integrator. The amplifier also includes means for preventing the integrator from being driven into saturation. As a result, the time for the flux-locked loop to recover from the excitation pulses generated by the spectrometer is reduced. 7 figures.

  18. Second order optical nonlinearity of graphene due to electric quadrupole and magnetic dipole effects

    Science.gov (United States)

    Cheng, J. L.; Vermeulen, N.; Sipe, J. E.

    2017-01-01

    We present a practical scheme to separate the contributions of the electric quadrupole-like and the magnetic dipole-like effects to the forbidden second order optical nonlinear response of graphene, and give analytic expressions for the second order optical conductivities, calculated from the independent particle approximation, with relaxation described in a phenomenological way. We predict strong second order nonlinear effects, including second harmonic generation, photon drag, and difference frequency generation. We discuss in detail the controllability of these effects by tuning the chemical potential, taking advantage of the dominant role played by interband optical transitions in the response. PMID:28262762

  19. Development of nuclear magnetic and quadrupole resonance spectroscopy under 10 GPa class pressure

    Energy Technology Data Exchange (ETDEWEB)

    Kobayashi, R; Uchida, Y; Hirayama, K; Yamazaki, T; Fukazawa, H; Kohori, Y [Department of Physics, Graduate School of Science, Chiba University, Chiba 263-8522 (Japan); Takeshita, N, E-mail: hideto@nmr.s.chiba-u.ac.j [JST, TRIP, Chiyoda-ku, Tokyo 102-0075 (Japan)

    2010-03-01

    The high pressure nuclear magnetic resonance (NMR) and nuclear quadrupole resonance (NQR) are conventionally performed up to 3 GPa using piston cylinder cell. However, the NMR/NQR measurements beyond this pressure range are scarcely performed owing to the technical difficulty. Recently, we developed new high pressure NMR/NQR technique using cubic anvil apparatus in which highly hydrostatic pressure was obtained. Using the new method, the {sup 63}Cu-NQR signal of Cu{sub 2}O was observed up to 7.2GPa with high sensitivity. The use of MgO gasket in mini-cubic anvil apparatus was examined for enlarging pressure range.

  20. Mechanical Design of an Alternate Structure for LARP Nb3Sn Quadrupole Magnets for LHC

    CERN Document Server

    Anerella, M; Kovach, P; Schmalzle, J; Wanderer, P; Ambrosio, G; Lamm, M J; Caspi, S; Felice, H; Ferracin, P; Sabbi, G L

    2011-01-01

    An alternative structure for the 120 mm Nb3Sn quadrupole magnet is presently under development for use in the upgrade for LHC at CERN. The design aims to build existing technology developed in LARP with the LQ and HQ magnets and to further optimize the features required for operation in the accelerator. The structure includes features for maintaining mechanical alignment of the coils to achieve the required field quality. It also includes a helium containment vessel and provisions for cooling with 1.9 K helium. The development effort includes the assembly of a six inch model to verify required coil load is achieved. Status of the R&D effort and an update on the magnet design, including its incorporation into the design of a complete one meter cold mass is presented.

  1. New 2D Thermal Model Applied to an LHC Inner Triplet Quadrupole Magnet

    CERN Document Server

    Bielert, ER; Ten Kate, HHJ; Verweij, AP

    2011-01-01

    A newly developed numerical model is presented that enables to compute two-dimensional heat transfer and temperature distributions over the cross-section of superconducting accelerator magnets. The entire thermal path from strand-in-cable to heat sink, including helium channels is considered. Superfluid helium properties are combined with temperature- and field-dependent non-linear solid material properties. Interfacial interactions are also taken into account. The model is applied to the cross-section of an inner triplet quadrupole magnet featuring a new concept for the ground insulation. Beam loss profiles are implemented as main heat source. It is concluded that operational margins can be considerably increased by opening additional thermal paths, improving the cooling conditions.

  2. In Situ Characterisation of Permanent Magnetic Quadrupoles for focussing proton beams

    CERN Document Server

    Melone, J J; McCanny, T; Burris-Mog, T; Schramm, U; Grötschel, R; Akhmadaliev, S; Hanf, D; Spohr, K M; Bussmann, M; Cowan, T; Wiggins, S M; Mitchell, M R

    2011-01-01

    High intensity laser driven proton beams are at present receiving much attention. The reasons for this are many but high on the list is the potential to produce compact accelerators. However two of the limitations of this technology is that unlike conventional nuclear RF accelerators lasers produce diverging beams with an exponential energy distribution. A number of different approaches have been attempted to monochromise these beams but it has become obvious that magnetic spectrometer technology developed over many years by nuclear physicists to transport and focus proton beams could play an important role for this purpose. This paper deals with the design and characterisation of a magnetic quadrupole system which will attempt to focus and transport laser-accelerated proton beams.

  3. 1999 Review of superconducting dipole and quadrupole magnets for particle accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Devred, A. [CEA/Saclay, Dept. d' Astrophysique, de la Physique des Particules, de la Physique Nucleaire et de l' Instrumentation Associee (DAPNIA), 91 - Gif-sur-Yvette (France); CERN, Conseil Europeen pour la recherche nucleaire, Laboratoire europeen pour la physique des particules Geneve (Switzerland)

    1999-12-01

    The quest for elementary particles has promoted the development of particle accelerators producing beams of increasingly higher energies. In a synchrotron-type accelerator, the particle energy is directly proportional to the product of the machine's radius times the bending magnets' field strength. Present proton experiments at the TeV scale require facilities with circumferences ranging from a few to tens of kilometers and relying on a large number (several hundreds to several thousands) of high field dipole magnets and high field gradient quadrupole magnets. These electro-magnets use high current density, low critical temperature superconducting cables and are cooled down at liquid helium temperature. They are among the most costly and the most challenging components of the machine. After explaining what are the various types of accelerator magnets and why they are needed (section 1), we present a brief history of large superconducting particle accelerators, and we detail ongoing superconducting accelerator magnet R and D programs around the world (Section 2). Then, we review the superconducting materials that are available at industrial scale (chiefly, NbTi and Nb3Sn), and we describe the manufacturing of NbTi wires and cables (section 3). We also present the difficulties of processing and insulating Nb3Sn conductors which, so far, have limited the use of this material in spite of its superior performances. We continue by presenting the complex formalism used to represent two-dimensional fields (section 4), and we discuss the two-dimensional current distributions that are the most appropriate for generating pure dipole and pure quadrupole fields (section 5). We explain how these ideal distributions can be approximated by so-called cos{theta} and cos{sup 2}{theta} coil designs and we describe the difficulties of realizing coil ends. Next, we present the mechanical design concepts that have been developed to restrain magnet coils and to ensure proper

  4. Using injection molding and reversible bonding for easy fabrication of magnetic cell trapping and sorting devices

    Science.gov (United States)

    Royet, David; Hériveaux, Yoann; Marchalot, Julien; Scorretti, Riccardo; Dias, André; Dempsey, Nora M.; Bonfim, Marlio; Simonet, Pascal; Frénéa-Robin, Marie

    2017-04-01

    Magnetism and microfluidics are two key elements for the development of inexpensive and reliable tools dedicated to high-throughput biological analysis and providing a large panel of applications in domains ranging from fundamental biology to medical diagnostics. In this work, we introduce a simple protocol, relying on injection molding and reversible bonding for fabrication of magnetic cell trapping and sorting devices using only standard soft-lithography equipment. Magnetic strips or grids made of Polydimethylsiloxane (PDMS) doped with hard (NdFeB) or soft (carbonyl iron) magnetic powders were integrated at the bottom of whole PDMS chips. Preliminary results show the effective deviation/trapping of magnetic beads or magnetically-labeled bacteria as the sample flows through the microchannel, proving the potential of this rapid prototyping approach for easy fabrication of magnetic cell sorters.

  5. Test Results of the Third LHC Main Quadrupole Magnet Prototype at CEA/Saclay

    CERN Document Server

    Derégel, J; Gourdin, C; Hervieu, M; Ogitsu, T; Peyrot, M; Rifflet, J M; Schild, T; Simon, F; Tortschanoff, Theodor; Tsuchiya, K

    2002-01-01

    The construction of the third second-generation main quadrupole magnet prototype for LHC has been completed at CEA/Saclay in November 2000. The magnet was tested at 1.9 K. Similarly to the two first ones, this prototype has exceeded the operating current in one training step and exhibited excellent training memory after a thermal cycle. This paper describes the quench performance and quench start localization determined by means of voltage-taps and a quench antenna system developed in collaboration with KEK. As this magnet was equipped with capacitive gauges, the stresses during cool-down and powering have been recorded and are in agreement with FE computations. The newly designed quench heaters have improved efficiency and reproducibility compared to those of the first generation. Magnetic measurements have been performed at various stages. The cold measurements show minor differences with those at room temperature and are similar to those of the two first magnets of this design. These results prove that the...

  6. Quadrupole order in the frustrated pyrochlore magnet Tb2Ti2O7

    Science.gov (United States)

    Takatsu, H.; Taniguchi, T.; Kittaka, S.; Sakakibara, T.; Kadowaki, H.

    2016-02-01

    We have studied the hidden long-range order (LRO) of the frustrated pyrochlore magnet Tb2Ti2O7 by means of specific-heat experiments and Monte-Carlo (MC) simulations, which has been discussed as the LRO of quadrupole moments inherent to the non-Kramers ion of Tb3+. We have found that the sharp specific-heat peak is collapsed into a broad hump by magnetic fields above 0.3 T for H//[001]. This result, qualitatively reproduced by MC simulations, suggests that a field-induced magnetic state overcomes the quadrupolar LRO state, as a similar case of a classical spin ice. The present results support the interpretation that Tb2+xTi2-xO7+y is a unique material in the boundary between the quadrupolar (x ⩾ xc = - 0.0025) and spin-liquid (x ⩽ xc) states, where the magnetic field along the [001] axis is a tuning parameter which induces the magnetic ordered state.

  7. Development and manufacturing of a Nb$_{3}$Sn quadrupole magnet Model at CEA/Saclay for TESLA Interaction Region

    CERN Document Server

    Durante, Maria; Fratini, M; Leboeuf, D; Segreti, M; Védrine, Pierre; 10.1109/TASC.2004.829129

    2004-01-01

    One possible application of Nb/sub 3/Sn, whose superconducting properties far exceed those of NbTi, is the fabrication of short and powerful quadrupole magnets for the interaction regions of large particle accelerators. In some projects, as in the future linear collider TESLA, the quadrupole magnets are inside the detector solenoid and must operate in its background field. This situation gives singular Lorentz force distribution in the ends of the magnet. To learn about Nb/sub 3/Sn technology, evaluate fabrication techniques and test the interaction with a solenoidal field, DAPNIA /SACM at CEA/Saclay has started the manufacturing of a 1-m-long, 56- mm-single-aperture quadrupole magnet model. The model relies on the same coil geometry as the LHC arc quadrupole magnets, but has no iron yoke. It will produce a nominal field gradient of 211 T/m at 11,870 A. The coils are wound from Rutherford-type cables insulated with glass fiber tape, before being heat-treated and vacuum-impregnated with epoxy resin. Laminated,...

  8. Characterization of the ELIMED Permanent Magnets Quadrupole system prototype with laser-driven proton beams

    Science.gov (United States)

    Schillaci, F.; Pommarel, L.; Romano, F.; Cuttone, G.; Costa, M.; Giove, D.; Maggiore, M.; Russo, A. D.; Scuderi, V.; Malka, V.; Vauzour, B.; Flacco, A.; Cirrone, G. A. P.

    2016-07-01

    Laser-based accelerators are gaining interest in recent years as an alternative to conventional machines [1]. In the actual ion acceleration scheme, energy and angular spread of the laser-driven beams are the main limiting factors for beam applications and different solutions for dedicated beam-transport lines have been proposed [2,3]. In this context a system of Permanent Magnet Quadrupoles (PMQs) has been realized [2] by INFN-LNS (Laboratori Nazionali del Sud of the Instituto Nazionale di Fisica Nucleare) researchers, in collaboration with SIGMAPHI company in France, to be used as a collection and pre-selection system for laser driven proton beams. This system is meant to be a prototype to a more performing one [3] to be installed at ELI-Beamlines for the collection of ions. The final system is designed for protons and carbons up to 60 MeV/u. In order to validate the design and the performances of this large bore, compact, high gradient magnetic system prototype an experimental campaign have been carried out, in collaboration with the group of the SAPHIR experimental facility at LOA (Laboratoire d'Optique Appliquée) in Paris using a 200 TW Ti:Sapphire laser system. During this campaign a deep study of the quadrupole system optics has been performed, comparing the results with the simulation codes used to determine the setup of the PMQ system and to track protons with realistic TNSA-like divergence and spectrum. Experimental and simulation results are good agreement, demonstrating the possibility to have a good control on the magnet optics. The procedure used during the experimental campaign and the most relevant results are reported here.

  9. H-mode accelerating structures with permanent-magnet quadrupole beam focusing

    Science.gov (United States)

    Kurennoy, S. S.; Rybarcyk, L. J.; O'Hara, J. F.; Olivas, E. R.; Wangler, T. P.

    2012-09-01

    We have developed high-efficiency normal-conducting rf accelerating structures by combining H-mode resonator cavities and a transverse beam focusing by permanent-magnet quadrupoles (PMQ), for beam velocities in the range of a few percent of the speed of light. The shunt impedance of interdigital H-mode (IH-PMQ) structures is 10-20 times higher than that of a conventional drift-tube linac, while the transverse size is 4-5 times smaller. Results of the combined 3D modeling—electromagnetic computations, multiparticle beam-dynamics simulations with high currents, and thermal-stress analysis—for an IH-PMQ accelerator tank are presented. The accelerating-field profile in the tank is tuned to provide the best propagation of a 50-mA deuteron beam using coupled iterations of electromagnetic and beam-dynamics modeling. Measurements of a cold model of the IH-PMQ tank show a good agreement with the calculations. Examples of cross-bar H-mode structures with PMQ focusing for higher beam velocities are also presented. H-PMQ accelerating structures following a short radio-frequency quadrupole accelerator can be used both in the front end of ion linacs or in stand-alone applications.

  10. The development of magnetic field measurement system for drift-tube linac quadrupole

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Jianxin, E-mail: zhoujx@ihep.ac.cn [Key Laboratory of Particle Acceleration Physics and Technology, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); China Spallation Neutron Source (CSNS), Institute of High Energy Physics (IHEP), Chinese Academy of Sciences CAS, Dongguan 523803 (China); Dongguan Neutron Science Center, Dongguan 523808 (China); Kang, Wen [Key Laboratory of Particle Acceleration Physics and Technology, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); China Spallation Neutron Source (CSNS), Institute of High Energy Physics (IHEP), Chinese Academy of Sciences CAS, Dongguan 523803 (China); Dongguan Neutron Science Center, Dongguan 523808 (China); Yin, Baogui; Peng, Quanling [Key Laboratory of Particle Acceleration Physics and Technology, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); Li, Li; Liu, Huachang; Gong, Keyun; Li, Bo; Chen, Qiang; Li, Shuai; Liu, Yiqin [Key Laboratory of Particle Acceleration Physics and Technology, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); China Spallation Neutron Source (CSNS), Institute of High Energy Physics (IHEP), Chinese Academy of Sciences CAS, Dongguan 523803 (China); Dongguan Neutron Science Center, Dongguan 523808 (China)

    2015-06-21

    In the China Spallation Neutron Source (CSNS) linac, a conventional 324 MHz drift-tube linac (DTL) accelerating an H{sup −} ion beam from 3 MeV to 80 MeV has been designed and manufactured. The electromagnetic quadrupoles (EMQs) are widely used in a DTL accelerator. The main challenge of DTLQ's structure is to house a strong gradient EMQ in the much reduced space of the drift-tube (DT). To verify the DTLQ's design specifications and fabrication quality, a precision harmonic coil measurement system has been developed, which is based on the high precision movement platform, the harmonic coil with ceramic frame and the special method to make the harmonic coil and the quadrupoles coaxial. After more than one year's continuous running, the magnetic field measurement system still performs accurately and stably. The field measurement of more than one hundred DTLQ has been finished. The components and function of the measurement system, the key point of the technology and the repeatability of the measurement results are described in this paper.

  11. The development of magnetic field measurement system for drift-tube linac quadrupole

    Science.gov (United States)

    Zhou, Jianxin; Kang, Wen; Yin, Baogui; Peng, Quanling; Li, Li; Liu, Huachang; Gong, Keyun; Li, Bo; Chen, Qiang; Li, Shuai; Liu, Yiqin

    2015-06-01

    In the China Spallation Neutron Source (CSNS) linac, a conventional 324 MHz drift-tube linac (DTL) accelerating an H- ion beam from 3 MeV to 80 MeV has been designed and manufactured. The electromagnetic quadrupoles (EMQs) are widely used in a DTL accelerator. The main challenge of DTLQ's structure is to house a strong gradient EMQ in the much reduced space of the drift-tube (DT). To verify the DTLQ's design specifications and fabrication quality, a precision harmonic coil measurement system has been developed, which is based on the high precision movement platform, the harmonic coil with ceramic frame and the special method to make the harmonic coil and the quadrupoles coaxial. After more than one year's continuous running, the magnetic field measurement system still performs accurately and stably. The field measurement of more than one hundred DTLQ has been finished. The components and function of the measurement system, the key point of the technology and the repeatability of the measurement results are described in this paper.

  12. Magnetic Measurements of the First Nb$_3$Sn Model Quadrupole (MQXFS) for the High-Luminosity LHC

    CERN Document Server

    DiMarco, J; Chlachidze, G; Ferracin, P; Holik, E; Sabbi, G; Stoynev, S; Strauss, T; Sylvester, C; Tartaglia, M; Todesco, E; Velev, G; Wang, X

    2016-01-01

    The US LHC Accelerator Research Program (LARP) and CERN are developing high-gradient Nb3Sn magnets for the High Luminosity LHC interaction regions. Magnetic measurements of the first 1.5 m long, 150 mm aperture model quadrupole, MQXFS1, were performed during magnet assembly at LBNL, as well as during cryogenic testing at Fermilab’s Vertical Magnet Test Facility. This paper reports on the results of these magnetic characterization measurements, as well as on the performance of new probes developed for the tests.

  13. Magnetic Measurements of the First Nb$_3$Sn Model Quadrupole (MQXFS) for the High-Luminosity LHC

    Energy Technology Data Exchange (ETDEWEB)

    DiMarco, J. [Fermilab; Ambrosio, G. [Fermilab; Chlachidze, G. [Fermilab; Ferracin, P. [CERN; Holik, E. [Fermilab; Sabbi, G. [LBNL, Berkeley; Stoynev, S. [Fermilab; Strauss, T. [Fermilab; Sylvester, C. [Fermilab; Tartaglia, M. [Fermilab; Todesco, E. [CERN; Velev, G. [Fermilab; Wang, X. [LBL, Berkeley

    2016-09-06

    The US LHC Accelerator Research Program (LARP) and CERN are developing high-gradient Nb3Sn magnets for the High Luminosity LHC interaction regions. Magnetic measurements of the first 1.5 m long, 150 mm aperture model quadrupole, MQXFS1, were performed during magnet assembly at LBNL, as well as during cryogenic testing at Fermilab’s Vertical Magnet Test Facility. This paper reports on the results of these magnetic characterization measurements, as well as on the performance of new probes developed for the tests.

  14. Hyperfine-induced electric dipole contributions to the electric octupole and magnetic quadrupole atomic clock transitions

    CERN Document Server

    Dzuba, V A

    2016-01-01

    Hyperfine-induced electric dipole contributions may significantly increase probabilities of otherwise very weak electric octupole and magnetic quadrupole atomic clock transitions (e.g. transitions between $s$ and $f$ electron orbitals). These transitions can be used for exceptionally accurate atomic clocks, quantum information processing and search for dark matter. They are very sensitive to new physics beyond the Standard Model, such as temporal variation of the fine structure constant, the Lorentz invariance and Einstein equivalence principle violation. We formulate conditions under which the hyperfine-induced electric dipole contribution dominates. Due to the hyperfine quenching the electric octupole clock transition in $^{173}$Yb$^+$ is two orders of magnitude stronger than that in currently used $^{171}$Yb$^+$. Some enhancement is found in $^{143}$Nd$^{13+}$, $^{149}$Pm$^{14+}$, $^{147}$Sm$^{14+}$, and $^{147}$Sm$^{15+}$ ions.

  15. Magnetic quadrupoles lens for hot spot proton imaging in inertial confinement fusion

    Energy Technology Data Exchange (ETDEWEB)

    Teng, J. [Science and Technology on Plasma Physics Laboratory, Laser Fusion Research Center, China Academy of Engineering Physics, Mianyang 621900 (China); Gu, Y.Q., E-mail: yqgu@caep.cn [Science and Technology on Plasma Physics Laboratory, Laser Fusion Research Center, China Academy of Engineering Physics, Mianyang 621900 (China); Center for Applied Physics and Technology, HEDPS, Peking University, Beijing 100871 (China); Chen, J.; Zhu, B.; Zhang, B.; Zhang, T.K.; Tan, F.; Hong, W.; Zhang, B.H. [Science and Technology on Plasma Physics Laboratory, Laser Fusion Research Center, China Academy of Engineering Physics, Mianyang 621900 (China); Wang, X.Q. [Academy of Nuclear Science and Technology, University of Science and Technology of China, Hefei 230026 (China)

    2016-08-01

    Imaging of DD-produced protons from an implosion hot spot region by miniature permanent magnetic quadrupole (PMQ) lens is proposed. Corresponding object-image relation is deduced and an adjust method for this imaging system is discussed. Ideal point-to-point imaging demands a monoenergetic proton source; nevertheless, we proved that the blur of image induced by proton energy spread is a second order effect therefore controllable. A proton imaging system based on miniature PMQ lens is designed for 2.8 MeV DD-protons and the adjust method in case of proton energy shift is proposed. The spatial resolution of this system is better than 10 μm when proton yield is above 10{sup 9} and the spectra width is within 10%.

  16. Shell-based support structures for Nb$_{3}$Sn accelerator quadrupole magnets

    CERN Document Server

    Ferracin, P

    2009-01-01

    Shell-based support structures are being fabricated and tested as part of the development of large-aperture Nb3Sn superconducting quadrupoles for future upgrades of the LHC Interaction Regions. These structures utilize water pressurized bladders for room-temperature pre-load control, and rely on a pre-tensioned aluminum shell to deliver a substantial part of the coil pre-stress during cooldown. The coil final pre-load is therefore monotonically approached from below, without overstressing the strainsensitive conductor. This method has been adopted by the US LARP collaboration to test subscale racetrack coils (SQ series), 1 m long cos-theta coils (TQS series), and 4 m long magnets (LRS and LQS series). We present recent progress in the development of shell-based support structures, with a description of the principles of operations and the future plans.

  17. Electron scale nested quadrupole Hall field in Cluster observations of magnetic reconnection

    CERN Document Server

    Jain, Neeraj

    2014-01-01

    This Letter presents the first evidence of a new and unique feature of spontaneous reconnection at multiple sites in electron current sheet, viz. nested quadrupole structure of Hall field at electron scales, in Cluster observations. The new nested quadrupole is a consequence of electron scale processes in reconnection. Whistler response of the upstream plasma to the interaction of electron flows from neighboring reconnection sites produces a large scale quadrupole Hall field enclosing the quadrupole fields of the multiple sites, thus forming a nested structure. Electron-magnetohydrodynamic simulations of an electron current sheet yields mechanism of the formation of nested quadrupole.

  18. Design of a Microfluidic Chip for Magnetic-Activated Sorting of One-Bead-One-Compound Libraries.

    Science.gov (United States)

    Cho, Choi-Fong; Lee, Kyungheon; Speranza, Maria-Carmela; Bononi, Fernanda C; Viapiano, Mariano S; Luyt, Leonard G; Weissleder, Ralph; Chiocca, E Antonio; Lee, Hakho; Lawler, Sean E

    2016-06-13

    Molecular targeting using ligands specific to disease markers has shown great promise for early detection and directed therapy. Bead-based combinatorial libraries have served as powerful tools for the discovery of novel targeting agents. Screening platforms employing magnetic capture have been used to achieve rapid and efficient identification of high-affinity ligands from one-bead-one-compound (OBOC) libraries. Traditional manual methodologies to isolate magnetized "hit" beads are tedious and lack accuracy, and existing instruments to expedite bead sorting tend to be costly and complex. Here, we describe the design and construction of a simple and inexpensive microfluidic magnetic sorting device using standard photolithography and soft lithography approaches to facilitate high-throughput isolation of magnetized positive hit beads from combinatorial libraries. We have demonstrated that the device is able to sort magnetized beads with superior accuracy compared to conventional manual sorting approaches. This chip offers a very convenient yet inexpensive alternative for screening OBOC libraries.

  19. Engineering Design and Manufacturing Challenges for a Wide-Aperture, Superconducting Quadrupole Magnet

    CERN Document Server

    Kirby, G A; Bielert, E; Fessia, P; Karppinen, M; Lepoittevin, B; Lorin, C; Luzieux, S; Perez, J C; Russenschuck, S; Sahner, T; Smekens, D; Segreti, M; Durante, M

    2012-01-01

    The design and construction of a wide-aperture, superconducting quadrupole magnet for the LHC insertion region is part of a study towards a luminosity upgrade of the LHC at CERN. The engineering design of components and tooling, the procurement, and the construction work presented in this paper includes innovative features such as more porous cable insulation, a new collar structure allowing horizontal assembly with a hydraulic collaring press, tuning shims for the adjustment of field quality, a fishbone like structure for the ground-plane insulation, and an improved quench-heater design. Rapid prototyping of coil-end spacers and trial-coil winding led to improved shapes, thus avoiding the need to impregnate the ends with epoxy resin, which would block the circulation of helium. The magnet construction follows established procedures for the curing and assembly of the coils, in order to match the workflow established in CERN’s ”large magnet facility.” This requirement led to the design and procurement of...

  20. Selection of nonapoptotic sperm by magnetic-activated cell sorting in Senegalese sole (Solea senegalensis).

    Science.gov (United States)

    Valcarce, D G; Herráez, M P; Chereguini, O; Rodríguez, C; Robles, V

    2016-09-15

    Senegalese sole (Solea senegalensis) is a promising species in aquaculture. However, owing to decreased sperm quality in F1 generations and the absence of courtship in those individuals born in captivity, artificial fertilization is being used to generate new progenies. The objective of this study was to implement a sperm selection method for nonapoptotic sperm subpopulation recovery before sperm cryopreservation. In particular, magnetic-activated cell sorting is used to eliminate apoptotic spermatozoa. This study represents the proof-of-concept for magnetic-activated cell sorting applicability in teleost species relevant in aquaculture. Apoptotic cell population was studied by flow cytometry using YO-PRO-1 and a caspase detection kit. Also, reactive oxygen species were measured in sperm samples. Our data demonstrated that caspase detection is more specific than YO-PRO-1 in the identification of apoptotic cells in S senegalensis seminal samples. The results showed that the percentage of apoptotic cells (caspase positive) was significantly higher (P = 0.04) in seminal samples from F1 than that from wild individuals. Magnetic-activated cell sorting removed a significant number of apoptotic cells from the samples (54% and 75% in wild and F1 individuals, respectively), decreasing the level of cells positive for reactive oxygen species (P = 0.17). In conclusion, this technique reduces the percentage of nonfunctional spermatozoa in a seminal sample before cryopreservation. This novel technique can be applied directly in the aquaculture industry.

  1. An adjustable focusing system for a 2 MeV H- ion beam line based on permanent magnet quadrupoles

    CERN Document Server

    Nirkko, M; Ereditato, A; Kreslo, I; Scampoli, P; Weber, M

    2012-01-01

    A compact adjustable focusing system for a 2 MeV H- RFQ Linac is designed, constructed and tested based on four permanent magnet quadrupoles (PMQ). A PMQ model is realised using finite element simulations, providing an integrated field gradient of 2.35 T with a maximal field gradient of 57 T/m. A prototype is constructed and the magnetic field is measured, demonstrating good agreement with the simulation. Particle track simulations provide initial values for the quadrupole positions. Accordingly, four PMQs are constructed and assembled on the beam line, their positions are then tuned to obtain a minimal beam spot size of (1.2 x 2.2) mm^2 on target. This paper describes an adjustable PMQ beam line for an external ion beam. The novel compact design based on commercially available NdFeB magnets allows high flexibility for ion beam applications.

  2. An improved permanent magnet quadrupole design with larger good field region for high intensity proton linacs

    Energy Technology Data Exchange (ETDEWEB)

    Mathew, Jose V., E-mail: josev.mathew@gmail.com; Rao, S.V.L.S.; Krishnagopal, S.; Singh, P.

    2013-11-01

    The Low Energy High Intensity Proton Accelerator (LEHIPA), being developed at the Bhabha Atomic Research Centre (BARC) will produce a 20 MeV, 30 mA, continuous wave (CW) proton beam. At these low velocities, space-charge forces dominate, and could lead to larger beam sizes and beam halos. Hence in the design of the focusing lattice of the LEHIPA drift tube linac (DTL) using permanent magnet quadrupoles (PMQs), a larger good field region is preferred. Here we study, using the two dimensional (2D) and three dimensional (3D) simulation codes PANDIRA and RADIA, four different types of cylindrical PMQ designs: 16-segment trapezoidal Halbach configuration, bullet-nosed geometry and 8- and 16-segment rectangular geometries. The trapezoidal Halbach geometry is used in a variety of accelerators since it provides very high field gradients in small bores, while the bullet-nosed geometry, which is a combination of the trapezoidal and rectangular designs, is used in some DTLs. This study shows that a larger good field region is possible in the 16-segment rectangular design as compared to the Halbach and bullet-nosed designs, making it more attractive for high-intensity proton linacs. An improvement in good-field region by ∼16% over the Halbach design is obtained in the optimized 16-segment rectangular design, although the field gradient is lower by ∼20%. Tolerance studies show that the rectangular segment PMQ design is substantially less sensitive to the easy axis orientation errors and hence will be a better choice for DTLs. -- Highlights: • An improved permanent magnet quadrupole (PMQ) design with larger good field region is proposed. • We investigate four PMQ designs, including the widely used Halbach and bullet nosed designs. • Analytical calculations are backed by 2D as well as 3D numerical solvers, PANDIRA and RADIA. • The optimized 16 segment rectangular PMQ design is identified to exhibit the largest good field region. • The effect of easy axis orientation

  3. Low-frequency nuclear magnetic resonance and nuclear quadrupole resonance spectrometer based on a dc superconducting quantum interference device

    Science.gov (United States)

    Fan, N. Q.; Clarke, John

    1991-06-01

    A sensitive spectrometer, based on a dc superconducting quantum interference device, for the direct detection of low-frequency pulsed nuclear magnetic resonance (NMR) and nuclear quadrupole resonance (NQR), is described. The frequency response extends from about 10 to 200 kHz, and the recovery time after the magnetic pulse is removed is typically 50 μs. As examples, NMR spectra are shown from Pt and Cu metal powders in a magnetic field of 6 mT, and NQR spectra are shown from 2D in a tunneling methyl group and 14N in NH4ClO4.

  4. Magnetic and quadrupole moments of neutron deficient $^{58-62}$Cu isotopes

    CERN Document Server

    Flanagan, K T; Blaum, K; Forest, D H; Stroke, H H; Kramer, J; Kreim, K; De Rydt, M; Geppert, C; Sanchez, R; Honma, M; Krieger, A; Papuga, J; Billowes, J; Vingerhoets, P; Nortershauser, W; Bissell, M L; Neyens, G; Rajabali, M M; Yordanov, D T; Cheal, B; Neugart, R; Procter, T J

    2011-01-01

    This paper reports on the ground state nuclear moments measured in (58-62)Cu using collinear laser spectroscopy at the ISOLDE facility. The quadrupole moments for (58-60)Cu have been measured for the first time as Q ((58)Cu) = 15(3) efm(2), Q ((59)Cu) = -19.3(19) efm(2), Q((60)Cu) = +11.6(12) efm(2) and with higher precision for (61.62)Cu as Q ((61)Cu) = -21.1(10) efm(2), Q((62)Cu) = -2.2(4) efm(2). The magnetic moments of (58.59)Cu are measured with a higher precision as(IL)((58)Cu) = +0.570(2)(ILN) and (IL)((59)Cu) = +1.8910(9)(ILN). The experimental nuclear moments are compared to large-scale shell-model calculations with the GXPF1 and GXPF1A effective interactions, allowing the softness of the (56)Ni core to be studied. (C) 2011 Published by Elsevier B.V.

  5. Time-Reversal Symmetry Violation in Molecules Induced by Nuclear Magnetic Quadrupole Moments

    Science.gov (United States)

    Flambaum, V. V.; DeMille, D.; Kozlov, M. G.

    2014-09-01

    Recent measurements in paramagnetic molecules improved the limit on the electron electric dipole moment (EDM) by an order of magnitude. Time-reversal (T) and parity (P) symmetry violation in molecules may also come from their nuclei. We point out that nuclear T, P-odd effects are amplified in paramagnetic molecules containing deformed nuclei, where the primary effects arise from the T, P-odd nuclear magnetic quadrupole moment (MQM). We perform calculations of T, P-odd effects in the molecules TaN, ThO, ThF+, HfF+, YbF, HgF, and BaF induced by MQMs. We compare our results with those for the diamagnetic TlF molecule, where the T, P-odd effects are produced by the nuclear Schiff moment. We argue that measurements in molecules with MQMs may provide improved limits on the strength of T, P-odd nuclear forces, on the proton, neutron, and quark EDMs, on quark chromo-EDMs, and on the QCD θ term and CP-violating quark interactions.

  6. Construction and measurement of the pre-series twin aperture resistive quadrupole magnet for the LHC beam cleaning insertions

    CERN Document Server

    de Rijk, G; Boter, E; Clark, G S; Hans, O; Racine, M; Salinas, A

    2002-01-01

    CERN's Large Hadron Collider (LHC) requires 48 twin aperture resistive quadrupoles in the beam cleaning insertions. Canada is contributing these magnets to CERN in the framework of the TRIUMF-LHC collaboration contracts. A pre-series magnet was produced by Canadian industry and delivered in March 2001. This magnet incorporates important design changes that resulted from experience with a prototype magnet. The construction of this pre-series magnet and the measurements made at ALSTOM and at CERN are reported. A comparison is made between high precision pole distance measurements and the magnetic measurements performed with a rotating coil mole. Conclusions for series production and possibilities for multipole corrections are outlined. (6 refs).

  7. Computational Fluid Dynamics Simulation of a Quadrupole Magnetic Sorter Flow Channel: Effect of Splitter Position on Nonspecific Crossover.

    Science.gov (United States)

    Sajja, V S K; Kennedy, David J; Todd, Paul W; Hanley, Thomas R

    2011-10-01

    In the Quadrupole Magnetic Sorter (QMS) magnetic particles enter a vertical flow annulus and are separated from non-magnetic particles by radial deflection into an outer annulus where the purified magnetic particles are collected via a flow splitter. The purity of magnetically isolated particles in QMS is affected by the migration of nonmagnetic particles across transport lamina in the annular flow channel. Computational Fluid Dynamics (CFD) simulations were used to predict the flow patterns, pressure drop and nonspecific crossover in QMS flow channel for the isolation of pancreatic islets of Langerhans. Simulation results were compared with the experimental results to validate the CFD model. Results of the simulations were used to show that one design gives up to 10% less nonspecific crossover than another and this model can be used to optimise the flow channel design to achieve maximum purity of magnetic particles.

  8. Quadrupole magnetic mapping of the high resolution spectrometers of Thomas Jefferson National Accelerator Laboratory, Hall A. (Q.M.M. project: Quadrupole Magnetic Measurement); Cartographie magnetique des quadripoles des spectrometre a haute resolution du Thomas Jefferson National Accelerator Laboratory, Hall A. (Le projet Q.M.M.: Quadrupole Magnetic Measurement)

    Energy Technology Data Exchange (ETDEWEB)

    Quemener, Gilles [Ecole Doctorale des Science Fondamentales, Universite Blaise Pascal, U.F.R. de Recherche Scientifique et Technique, F-63177 Aubiere Cedex (France)

    1997-12-19

    This thesis describes the magnetic measurements that have been performed on the superconducting quadrupoles of the High Resolution Spectrometers of TJNAF, Hall A (USA), which are designed to measure particle momentum up to 4 GeV.c{sup -1} with a {sigma}p/p = 10{sup -4} resolution. The mapping method is based on rotating coil technique, the originality being a segmentation of the probe along the quad axis. Together with an accurate magnet modelling, the measurement of the flux variations through the set of rotating coils allows to determine the magnetic field at each point. We use the 3D field formalism, i.e., the Fourier-Bessel expansion of the field obtained by solving the Laplace equation. We describe the QMM method and then the apparatus consisting in two probes of length 1.6 m and 3.2 m built to map the three quadrupoles Q1, Q2, Q3. Data processing uses Fourier analysis. The mapping of the Electron Arm took place in situ in 1996. A first set of results concerns integral measurements including the properties of excitation cycle of the magnets (saturation and hysteresis). Second set of results in terms of local field yields the 3D field maps of the quadrupoles. After having applied corrections to the data we obtain a local field accuracy of 5 Gauss on each component, i.e. an uncertainty of 5.10{sup -4} relative to the quadrupole central field. We use SNAKE ray-tracing code with the implementation of QMM field maps and obtain preliminary results on HRS optics. (author) 48 refs., 93 figs., 41 tabs.

  9. An efficient method of sorting liver stem cells by using immuno-magnetic microbeads

    Institute of Scientific and Technical Information of China (English)

    Yu-Fei He; Yin-Kun Liu; Dong-Mei Gao; Jun Chen; Peng-Yuan Yang

    2006-01-01

    AIM: To develop a method to isolate liver stem cells fast and efficiently.METHODS: Fetal mouse liver cells were characterized by cell surface antigens (c-Kit and CD45/TER119) using flow cytometry. The candidate liver stem cells were sorted by using immuno-magnetic microbeads and identified by clone-forming culture, RT-PCR and immunofluorescence assays.RESULTS: The c-Kit-(CD45/TER119)-cell population with 97.9% of purity were purified by immuno-magnetic microbeads at one time. The yield of this separation was about 6% of the total sorting cells and the cell viability was above 98%. When cultured in vitro these cells had high clone-forming and self-renewing ability and expressed markers of hepatocytes and bile duct cells.Functionally mature hepatocytes were observed after 21 d of culture.CONCLUSION: This method offers an excellent tool for the enrichment of liver stem cells with high purity and viability, which could be used for further studies. It is fast, efficient, simple and not expensive.

  10. Purification of Immune Cell Populations from Freshly Isolated Murine Tumors and Organs by Consecutive Magnetic Cell Sorting and Multi-parameter Flow Cytometry-Based Sorting.

    Science.gov (United States)

    Salvagno, Camilla; de Visser, Karin E

    2016-01-01

    It is well established that tumors evolve together with nonmalignant cells, such as fibroblasts, endothelial cells, and immune cells. These cells constantly entangle and interact with each other creating the tumor microenvironment. Immune cells can exert both tumor-promoting and tumor-protective functions. Detailed phenotypic and functional characterization of intra-tumoral immune cell subsets has become increasingly important in the field of cancer biology and cancer immunology. In this chapter, we describe a method for isolation of viable and pure immune cell subsets from freshly isolated murine solid tumors and organs. First, we describe a protocol for the generation of single-cell suspensions from tumors and organs using mechanical and enzymatic strategies. In addition, we describe how immune cell subsets can be purified by consecutive magnetic cell sorting and multi-parameter flow cytometry-based cell sorting.

  11. Production of Low-Carbon Magnetic Steel for the LHC Superconducting Dipole and Quadrupole Magnets

    CERN Document Server

    Bertinelli, F; Harlet, P; Peiro, G; Russo, A; Taquet, A

    2006-01-01

    In 1996 CERN negotiated a contract with Cockerill Sambre – ARCELOR Group for the supply of 50 000 tonnes of low-carbon steel for the LHC main magnets: this was the first contract to be placed for the project, and one of the single largest. In 2005 – after nine years of work – the contract is being successfully completed. This paper describes the steel specifically developed, known as MAGNETIL™, its manufacturing and quality control process, organization of production, logistics and contract follow-up. Extensive statistics have been collected relating to physical, mechanical and technological parameters. Specific attention is dedicated to magnetic measurements (coercivity and permeability) performed at both room and cryogenic temperatures, the equipment used and statistical results. Reference is also made to the resulting precision of the fineblanked laminations used for the magnet yoke. The technology transfer from the particle accelerator domain to industry is ongoing, for example for ...

  12. The first LHC insertion quadrupole

    CERN Multimedia

    2004-01-01

    An important milestone was reached in December 2003 at the CERN Magnet Assembly Facility. The team from the Accelerator Technology - Magnet and Electrical Systems group, AT-MEL, completed the first special superconducting quadrupole for the LHC insertions which house the experiments and major collider systems. The magnet is 8 metres long and contains two matching quadrupole magnets and an orbit corrector, a dipole magnet, used to correct errors in quadrupole alignment. All were tested in liquid helium and reached the ultimate performance criteria required for the LHC. After insertion in the cryostat, the superconducting magnet will be installed as the Q9 quadrupole in sector 7-8, the first sector of the LHC to be put in place in 2004. Members of the quadrupole team, from the AT-MEL group, gathered around the Q9 quadrupole at its inauguration on 12 December 2003 in building 181.

  13. An improved permanent magnet quadrupole design with larger good field region for high intensity proton linacs

    Science.gov (United States)

    Mathew, Jose V.; Rao, S. V. L. S.; Krishnagopal, S.; Singh, P.

    2013-11-01

    The Low Energy High Intensity Proton Accelerator (LEHIPA), being developed at the Bhabha Atomic Research Centre (BARC) will produce a 20 MeV, 30 mA, continuous wave (CW) proton beam. At these low velocities, space-charge forces dominate, and could lead to larger beam sizes and beam halos. Hence in the design of the focusing lattice of the LEHIPA drift tube linac (DTL) using permanent magnet quadrupoles (PMQs), a larger good field region is preferred. Here we study, using the two dimensional (2D) and three dimensional (3D) simulation codes PANDIRA and RADIA, four different types of cylindrical PMQ designs: 16-segment trapezoidal Halbach configuration, bullet-nosed geometry and 8- and 16-segment rectangular geometries. The trapezoidal Halbach geometry is used in a variety of accelerators since it provides very high field gradients in small bores, while the bullet-nosed geometry, which is a combination of the trapezoidal and rectangular designs, is used in some DTLs. This study shows that a larger good field region is possible in the 16-segment rectangular design as compared to the Halbach and bullet-nosed designs, making it more attractive for high-intensity proton linacs. An improvement in good-field region by ˜16% over the Halbach design is obtained in the optimized 16-segment rectangular design, although the field gradient is lower by ˜20%. Tolerance studies show that the rectangular segment PMQ design is substantially less sensitive to the easy axis orientation errors and hence will be a better choice for DTLs.

  14. Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia.

    Science.gov (United States)

    Fortin, Jean-Paul; Wilhelm, Claire; Servais, Jacques; Ménager, Christine; Bacri, Jean-Claude; Gazeau, Florence

    2007-03-07

    Iron oxide colloidal nanomagnets generate heat when subjected to an alternating magnetic field. Their heating power, governed by the mechanisms of magnetic energy dissipation for single-domain particles (Brown and Néel relaxations), is highly sensitive to the crystal size, the material, and the solvent properties. This study was designed to distinguish between the contributions of Néel and Brownian mechanisms to heat generation. Anionic nanocrystals of maghemite and cobalt ferrite, differing by their magnetic anisotropy, were chemically synthesized and dispersed in an aqueous suspension by electrostatic stabilization. The particles were size-sorted by successive electrostatic phase separation steps. Parameters governing the efficiency of nanomagnets as heat mediators were varied independently; these comprised the particle size (from 5 to 16.5 nm), the solvent viscosity, magnetic anisotropy, and the magnetic field frequency and amplitude. The measured specific loss powers (SLPs) were in quantitative agreement with the results of a predictive model taking into account both Néel and Brown loss processes and the whole particle size distribution. By varying the carrier fluid viscosity, we found that Brownian friction within the carrier fluid was the main contributor to the heating power of cobalt ferrite particles. In contrast, Néel internal rotation of the magnetic moment accounted for most of the loss power of maghemite particles. Specific loss powers were varied by 3 orders of magnitude with increasing maghemite crystal size (from 4 to 1650 W/g at 700 kHz and 24.8 kA/m). This comprehensive parametric study provides the groundwork for the use of anionic colloidal nanocrystals to generate magnetically induced hyperthermia in various media, including complex systems and biological materials.

  15. Steady State Heat Deposits Modeling in the Nb3Sn Quadrupole Magnets for the Upgrade of the LHC Inner Triplet

    CERN Document Server

    Bocian, D; Barzi, E; Bossert, R; Caspi, S; Chlachidze, G; Dietderich, D; Feher, S; Felice, H; Ferracin, P; Hafalia, R; Kashikhin, V V; Lamm, M; Sabbi, G L; Turrioni, D; Wanderer, P; Zlobin, A V

    2012-01-01

    In hadron colliders such as the LHC, the energy deposited in the superconductors by the particles lost from the beams or coming from the collision debris may provoke quenches detrimental to the accelerator operation. In previous papers, a Network Model has been used to study the thermodynamic behavior of magnet coils and to calculate the quench levels in the LHC magnets for expected beam loss profiles. This model was subsequently used for thermal analysis and design optimization of Nb3Sn quadrupole magnets, which LARP (US LHC Accelerator Research Program) is developing for possible use in the LHC luminosity upgrade. For these new magnets, the heat transport efficiency from the coil to the helium bath needs to be determined and optimized. In this paper the study of helium cooling channels and the heat evacuation scheme are presented and discussed.

  16. Steady State Heat Deposits Modeling in the Nb3Sn Quadrupole Magnets for the Upgrade of the LHC Inner Triplet

    Energy Technology Data Exchange (ETDEWEB)

    Bocian, D.; Ambrosio, G.; Felice, H.; Barzi, E.; Bossert, R.; Caspi, S.; Chlachidze, G.; Dietderich, D.; Feher, S.; Ferracin, P.; Hafalia, R.; /Fermilab /Lawrence Berkeley Lab /Brookhaven

    2011-09-01

    In hadron colliders such as the LHC, the energy deposited in the superconductors by the particles lost from the beams or coming from the collision debris may provoke quenches detrimental to the accelerator operation. In previous papers, a Network Model has been used to study the thermodynamic behavior of magnet coils and to calculate the quench levels in the LHC magnets for expected beam loss profiles. This model was subsequently used for thermal analysis and design optimization of Nb{sub 3}Sn quadrupole magnets, which LARP (US LHC Accelerator Research Program) is developing for possible use in the LHC luminosity upgrade. For these new magnets, the heat transport efficiency from the coil to the helium bath needs to be determined and optimized. In this paper the study of helium cooling channels and the heat evacuation scheme are presented and discussed.

  17. Purification of Definitive Endoderm Generated from Pluripotent Stem Cells by Magnetic Cell Sorting.

    Science.gov (United States)

    Diekmann, Ulf; Davenport, Claudia; Kresse, Jasmin; Naujok, Ortwin

    2017-02-02

    Pluripotent stem cells have the capability to differentiate into any somatic cell type of the human body. The generation of surrogate cells for the treatment of liver, lung, and pancreatic diseases is of great medical interest. First, the in vitro formation into cells of the definitive endoderm is required. Upon commitment into this lineage, the cells express transcription factors such as FOXA2, SOX17, HNF1B; GATA family members; and the surface protein CXCR4. Unfortunately, some pluripotent stem cells resist the differentiation and contaminate the culture. Thus, we describe here an endoderm differentiation protocol, which yields endoderm-committed cells in high numbers in a 4-day treatment protocol. Second, a method for the purification of CXCR4-positive endoderm cells by magnetic-activated cell sorting (MACS) and fluorescence-activated cell sorting (FACS) is described. The purification by MACS is quick and reliable and can be used to obtain pure endoderm cells either meant for downstream analysis such as omics or further differentiation experiments into endoderm-derived somatic cells. © 2017 by John Wiley & Sons, Inc. Copyright © 2017 John Wiley & Sons, Inc.

  18. Low-field permanent magnet quadrupoles in a new relativistic-klystron two-beam accelerator design

    Energy Technology Data Exchange (ETDEWEB)

    Yu, S.; Sessler, A. [Lawrence Berkeley Lab., CA (United States)

    1995-02-01

    Permanent magnets play a central role in the new relativistic klystron two-beam-accelerator design. The two key goals of this new design, low cost and the suppression of beam break-up instability are both intimately tied to the permanent magnet quadrupole focusing system. A recently completed systems study by a joint LBL-LLNL team concludes that a power source for a 1 TeV center-of-mass Next Linear Collider based on the new TBA design can be as low as $1 billion, and the efficiency (wall plug to rf) is estimated to be 36%. End-to-end simulations of longitudinal and transverse beam dynamics show that the drive beam is stable over the entire TBA unit.

  19. Systematically Asymmetric Heliospheric Magnetic Field: Evidence for a Quadrupole Mode and Non-Axisymmetry with Polarity Flip-Flops

    Science.gov (United States)

    Mursula, K.; Hiltula, T.

    2004-10-01

    Recent studies of the heliospheric magnetic field (HMF) have detected interesting, systematic hemispherical and longitudinal asymmetries which have a profound significance for the understanding of solar magnetic fields. The in situ HMF measurements since the 1960s show that the heliospheric current sheet (HCS) is systematically shifted (coned) southward during solar minimum times, leading to the concept of a bashful ballerina. While temporary shifts can be considerably larger, the average HCS shift (coning) angle is a few degrees, less than the 7.2∘ tilt of the solar rotation axis. Recent solar observations during the last two solar cycles verify these results and show that the magnetic areas in the northern solar hemisphere are larger and their intensity weaker than in the south during long intervals in the late declining to minimum phase. The multipole expansion reveals a strong quadrupole term which is oppositely directed to the dipole term. These results imply that the Sun has a symmetric quadrupole S0 dynamo mode that oscillates in phase with the dominant dipole A0 mode. Moreover, the heliospheric magnetic field has a strong tendency to produce solar tilts that are roughly opposite in longitudinal phase. This implies is a systematic longitudinal asymmetry and leads to a “flip-flop” type behaviour in the dominant HMF sector whose period is about 3.2 years. This agrees very well with the similar flip-flop period found recently in sunspots, as well as with the observed ratio of three between the activity cycle period and the flip-flop period of sun-like stars. Accordingly, these results require that the solar dynamo includes three modes, A0, S0 and a non-axisymmetric mode. Obviously, these results have a great impact on solar modelling.

  20. T2-weighted four dimensional magnetic resonance imaging with result-driven phase sorting

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Yilin; Yin, Fang-Fang; Cai, Jing, E-mail: jing.cai@duke.edu [Medical Physics Graduate Program, Duke University, Durham, North Carolina 27710 and Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710 (United States); Czito, Brian G. [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710 (United States); Bashir, Mustafa R. [Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710 (United States)

    2015-08-15

    Purpose: T2-weighted MRI provides excellent tumor-to-tissue contrast for target volume delineation in radiation therapy treatment planning. This study aims at developing a novel T2-weighted retrospective four dimensional magnetic resonance imaging (4D-MRI) phase sorting technique for imaging organ/tumor respiratory motion. Methods: A 2D fast T2-weighted half-Fourier acquisition single-shot turbo spin-echo MR sequence was used for image acquisition of 4D-MRI, with a frame rate of 2–3 frames/s. Respiratory motion was measured using an external breathing monitoring device. A phase sorting method was developed to sort the images by their corresponding respiratory phases. Besides, a result-driven strategy was applied to effectively utilize redundant images in the case when multiple images were allocated to a bin. This strategy, selecting the image with minimal amplitude error, will generate the most representative 4D-MRI. Since we are using a different image acquisition mode for 4D imaging (the sequential image acquisition scheme) with the conventionally used cine or helical image acquisition scheme, the 4D dataset sufficient condition was not obviously and directly predictable. An important challenge of the proposed technique was to determine the number of repeated scans (N{sub R}) required to obtain sufficient phase information at each slice position. To tackle this challenge, the authors first conducted computer simulations using real-time position management respiratory signals of the 29 cancer patients under an IRB-approved retrospective study to derive the relationships between N{sub R} and the following factors: number of slices (N{sub S}), number of 4D-MRI respiratory bins (N{sub B}), and starting phase at image acquisition (P{sub 0}). To validate the authors’ technique, 4D-MRI acquisition and reconstruction were simulated on a 4D digital extended cardiac-torso (XCAT) human phantom using simulation derived parameters. Twelve healthy volunteers were involved

  1. Unusual Enhancement of Magnetization by Pressure in the Antiferro-Quadrupole-Ordered Phase in CeB6

    Science.gov (United States)

    Ikeda, Suguru; Sera, Masafumi; Hane, Shingo; Uwatoko, Yoshiya; Kosaka, Masashi; Kunii, Satoru

    2007-06-01

    The effect of pressure on CeB6 was investigated by the measurement of the magnetization (M) under pressure, and we obtained the following results. The effect of pressure on M in phase I is very small. By applying pressure, TQ is enhanced, but TN and the critical field from the antiferromagnetic (AFM) phase III to the antiferro-quadrupole (AFQ) phase II (HcIII--II) are suppressed, as previously reported. The magnetization curve in phase III shows the characteristic shoulder at H˜ HcIII--II/2 at ambient pressure. This shoulder becomes much more pronounced by applying pressure. Both HcIII--II and the magnetic field, where a shoulder is seen in the magnetization curve in phase III, are largely suppressed by pressure. In phase II, the M-T curve at a low magnetic field exhibits an unusual concave temperature dependence below TQ down to TN. Thus, we found that the lower the magnetic field, the larger the enhancement of M in both phases III and II. To clarify the origin of the unusual pressure effect of M, we performed a mean-field calculation for the 4-sublattice model using the experimental results of dTQ/dP>0 and dTN/dP<0 and assuming the positive pressure dependence of the Txyz-antiferro-octupole (AFO) interaction. The characteristic features of the pressure effect of M obtained by the experiments could be reproduced well by the mean-field calculation. We found that the origin of the characteristic effect of pressure on CeB6 is the change in the subtle balance between the AFM interaction and the magnetic field-induced-effective FM interaction induced by the coexistence of the Oxy-AFQ and Txyz-AFO interactions under pressure.

  2. Characterization of laser-driven single and double electron bunches with a permanent magnet quadrupole triplet and pepper-pot mask

    Science.gov (United States)

    Manahan, G. G.; Brunetti, E.; Aniculaesei, C.; Anania, M. P.; Cipiccia, S.; Islam, M. R.; Grant, D. W.; Subiel, A.; Shanks, R. P.; Issac, R. C.; Welsh, G. H.; Wiggins, S. M.; Jaroszynski, D. A.

    2014-10-01

    Electron beams from laser-plasma wakefield accelerators have low transverse emittance, comparable to those from conventional radio frequency accelerators, which highlights their potential for applications, many of which will require the use of quadrupole magnets for optimal electron beam transport. We report on characterizing electron bunches where double bunches are observed under certain conditions. In particular, we present pepper-pot measurements of the transverse emittance of 120-200 MeV laser wakefield electron bunches after propagation through a triplet of permanent quadrupole magnets. It is shown that the normalized emittance at source can be as low as 1 π mm mrad (resolution limited), growing by about five times after propagation through the quadrupoles due to beam energy spread. The inherent energy-dependence of the magnets also enables detection of double electron bunches that could otherwise remain unresolved, providing insight into the self-injection of multiple bunches. The combination of quadrupoles and pepper-pot, in addition, acts as a diagnostic for the alignment of the magnetic triplet.

  3. Thermal stability at 1.9 K and 4.3 K of Nb3Sn cables for quadrupole magnets for the LHC upgrade

    NARCIS (Netherlands)

    Rapper, de W.M.; Dhalle, M.M.J.; Bordini, B.; Ballarino, A.; Kate, ten H.H.J.

    2013-01-01

    In the frame of the planned luminosity upgrade of the Large Hadron Collider, new quadrupole and dipole magnets are being designed and tested. Cabled conductors have been tested in the FRESCA test station to aid this effort. Part of this work is to characterize the thermal stability of the Nb3Sn cond

  4. MQXFS1 Quadrupole Design Report

    Energy Technology Data Exchange (ETDEWEB)

    Ambrosio, Giorgio [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States); et al.

    2016-04-14

    This report presents the reference design of MQXFS1, the first 1.5 m prototype of the low-beta quadrupoles (MQXF) for the LHC High Luminosity Upgrade. The MQXF quadrupoles have 150 mm aperture, coil peak field of about 12 T, and use $Nb_{3}Sn$ conductor. The design is based on the LARP HQ quadrupoles, which had 120 mm aperture. MQXFS1 has 1st generation cable cross-section and magnetic design.

  5. Development of an Eccentric CAM Based Active Pre-Alignment System for the CLIC Main Beam Quadrupole Magnet

    CERN Document Server

    Lackner, F; Collette, C; Mainaud Durand, H; Hauviller, C; Kemppinen, J; Leuxe, R

    2010-01-01

    CLIC (Compact Linear Collider) is a study for a future electron-positron collider that would allow physicists to explore a new energy region beyond the capabilities of today's particle accelerators. The demanding transverse and vertical beam sizes and emittance specifications are resulting in stringent alignment and a nanometre stability requirement. In the current feasibility study, the main beam quadrupole magnets have to be actively pre-aligned with a precision of 1 µm in 5 degrees of freedom (d.o.f.) before being mechanically stabilized to the nm scale above 1 Hz. This contribution describes the approach of performing this active pre-alignment based on an eccentric cam system. In order to limit the amplification of the vibration sources at resonant frequencies a sufficiently high Eigenfrequency is required. Therefore the contact region between cam and support was optimized for adequate stiffness based on the Hertzian theory. Furthermore, practical tests performed on a single degree of freedom mock-up wil...

  6. Frequency shifts in an optical lattice clock due to magnetic-dipole and electric-quadrupole transitions.

    Science.gov (United States)

    Taichenachev, A V; Yudin, V I; Ovsiannikov, V D; Pal'chikov, V G; Oates, C W

    2008-11-01

    We report a hitherto undiscovered frequency shift for forbidden J = 0-->J = 0 clock transitions excited in atoms confined to an optical lattice. These shifts result from magnetic-dipole and electric-quadrupole transitions, which have a spatial dependence in an optical lattice that differs from that of the stronger electric-dipole transitions. In combination with the residual translational motion of atoms in an optical lattice, this spatial mismatch leads to a frequency shift via differential energy level spacing in the lattice wells for ground state and excited state atoms. We estimate that this effect could lead to fractional frequency shifts as large as 10(-16), which might prevent lattice-based optical clocks from reaching their predicted performance levels. Moreover, these effects could shift the magic wavelength in lattice clocks in three dimensions by as much as 100 MHz, depending on the lattice configuration.

  7. Cold Test Results of the LARP HQ Nb3Sn Quadrupole Magnet at 1.9 K

    CERN Document Server

    Bajas, H; Anerella, M; Bajko, M; Bossert, R; Caspi, S; Chiuchiolo, A; Chlachidze, G; Dietderich, D; Dunkel, O; Felice, H; Ferracin, P; Feuvrier, J; Fiscarelli, L; Ghosh, A; Giloux, C; Godeke, A; Hafalia, A; Marchevsky, M; Russenschuck, S; Sabbi, G; Salmi, T; Schmalzle, J; Todesco, E; Wanderer, P; Wang, X; Yu, M

    2013-01-01

    The HQ magnet is a 120 mm aperture, 1-meter-long Nb3Sn quadrupole developed by the LARP collaboration in support of the High-Luminosity LHC project. Several tests were performed at LBNL in 2010-2011 achieving a maximum gradient of 170 T/m at 4.4 K. As a next step in the program, the latest model (HQ01e) was sent to CERN for testing at 1.9 K. As part of this test campaign, the magnet training has been done up to a maximum current of 16.2 kA corresponding to 85 % of the short sample limit. The ramp rate dependence of the quench current is also identified. The efficiency of the quench heaters is then studied at 4.2 K and at 1.9 K. The analyses of the magnet resistance evolution during fast current discharge showed evidence of quench whereas high energy quenches have been successfully achieved and sustained with no dump resistor.

  8. g-factor and quadrupole moment of the 212− isomeric state in 131La: Signature for a weakly-deformed magnetic rotational band head

    Directory of Open Access Journals (Sweden)

    Jasmeet Kaur

    2017-02-01

    Full Text Available The g-factor and the static quadrupole moment of a magnetic rotational band head 212− at 2121 keV in 131La have been determined by means of the time-differential perturbed angular distribution technique. The measured value of the g-factor, +1.060(4, is in agreement with the theoretical value for a three quasi-proton, π3{112−[505]⊗52+[422]⊗52+[413]} Nilsson configuration assignment. The observed spectroscopic quadrupole moment ratio, Qs(212−,131LaQs(192−,137La=0.457(4, supports the collective oblate shape (γ∼−60° with quadrupole deformation β2<0.07. The half-life of the 212− state, 37.2(1 ns, is re-measured with better accuracy.

  9. g-factor and quadrupole moment of the 21/2- isomeric state in 131La: Signature for a weakly-deformed magnetic rotational band head

    Science.gov (United States)

    Kaur, Jasmeet; Bansal, Neeraj; Bhati, A. K.; Kumar, R.; Sharma, Vijay R.; Kapoor, K.; Kumar, V.; Kaur, Navneet

    2017-02-01

    The g-factor and the static quadrupole moment of a magnetic rotational band head 21/2- at 2121 keV in 131La have been determined by means of the time-differential perturbed angular distribution technique. The measured value of the g-factor, + 1.060 (4), is in agreement with the theoretical value for a three quasi-proton, π3 {11/2- [ 505 ] ⊗5/2+ [ 422 ] ⊗5/2+ [ 413 ] } Nilsson configuration assignment. The observed spectroscopic quadrupole moment ratio, Qs (21/2- ,131 La)/Qs (19/2- ,137 La) = 0.457 (4), supports the collective oblate shape (γ ∼ - 60 °) with quadrupole deformation β2 < 0.07. The half-life of the 21/2- state, 37.2(1) ns, is re-measured with better accuracy.

  10. A quantitative determination of magnetic nanoparticle separation using on-off field operation of quadrupole magnetic field-flow fractionation (QMgFFF).

    Science.gov (United States)

    Orita, Toru; Moore, Lee R; Joshi, Powrnima; Tomita, Masahiro; Horiuchi, Takashi; Zborowski, Maciej

    2013-01-01

    Quadrupole Magnetic Field-Flow Fractionation (QMgFFF) is a technique for characterization of sub-micrometer magnetic particles based on their retention in the magnetic field from flowing suspensions. Different magnetic field strengths and volumetric flow rates were tested using on-off field application and two commercial nanoparticle preparations that significantly differed in their retention parameter, λ (by nearly 8-fold). The fractograms showed a regular pattern of higher retention (98.6% v. 53.3%) for the larger particle (200 nm v. 90 nm) at the higher flow rate (0.05 mL/min v. 0.01 mL/min) at the highest magnetic field (0.52 T), as expected because of its lower retention parameter. The significance of this approach is a demonstration of a system that is simpler in operation than a programmed field QMgFFF in applications to particle mixtures consisting of two distinct particle fractions. This approach could be useful for detection of unwanted particulate contaminants, especially important in industrial and biomedical applications.

  11. DC SQUID Spectrometers for Nuclear Quadrupole and Low-Field Nuclear Magnetic Resonance Spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    TonThat, Dinh M. [Univ. of California, Berkeley, CA (United States)

    1998-04-01

    The dc Superconducting Quantum Interference Device (SQUJD) is a very sensitive detector of magnetic flux, with a typical flux noise of the order of 1 μΦ0Hz-1/2 at liquid helium temperature (Φ0=h/2e). This inherent flux sensitivity of the SQUID is used in a spectrometer for the detection of nuclear magnetic resonance (NMR.)and nuclear quadruple resonance (NQR). The processing magnetic field from the nuclear spins is coupled to the SQUID by mean of a flux transformer. The SQUID NMR spectrometer is used to measure the longitudinal relaxation time T1 of solid 129Xe at 4.2 K down to 0.1 mT.

  12. Nuclear spins, magnetic moments and quadrupole moments of Cu isotopes from N = 28 to N = 46: probes for core polarization effects

    CERN Document Server

    Vingerhoets, P; Avgoulea, M; Billowes, J; Bissell, M L; Blaum, K; Brown, B A; Cheal, B; De Rydt, M; Forest, D H; Geppert, Ch; Honma, M; Kowalska, M; Kramer, J; Krieger, A; Mane, E; Neugart, R; Neyens, G; Nortershauser, W; Otsuka, T; Schug, M; Stroke, H H; Tungate, G; Yordanov, D T

    2010-01-01

    Measurements of the ground-state nuclear spins, magnetic and quadrupole moments of the copper isotopes from 61Cu up to 75Cu are reported. The experiments were performed at the ISOLDE facility, using the technique of collinear laser spectroscopy. The trend in the magnetic moments between the N=28 and N=50 shell closures is reasonably reproduced by large-scale shell-model calculations starting from a 56Ni core. The quadrupole moments reveal a strong polarization of the underlying Ni core when the neutron shell is opened, which is however strongly reduced at N=40 due to the parity change between the $pf$ and $g$ orbits. No enhanced core polarization is seen beyond N=40. Deviations between measured and calculated moments are attributed to the softness of the 56Ni core and weakening of the Z=28 and N=28 shell gaps.

  13. Direct current superconducting quantum interference device spectrometer for pulsed nuclear magnetic resonance and nuclear quadrupole resonance at frequencies up to 5 MHz

    Science.gov (United States)

    TonThat, Dinh M.; Clarke, John

    1996-08-01

    A spectrometer based on a dc superconducting quantum interference device (SQUID) has been developed for the direct detection of nuclear magnetic resonance (NMR) or nuclear quadrupole resonance (NQR) at frequencies up to 5 MHz. The sample is coupled to the input coil of the niobium-based SQUID via a nonresonant superconducting circuit. The flux locked loop involves the direct offset integration technique with additional positive feedback in which the output of the SQUID is coupled directly to a low-noise preamplifier. Precession of the nuclear quadrupole spins is induced by a magnetic field pulse with the feedback circuit disabled; subsequently, flux locked operation is restored and the SQUID amplifies the signal produced by the nuclear free induction signal. The spectrometer has been used to detect 27Al NQR signals in ruby (Al2O3[Cr3+]) at 359 and 714 kHz.

  14. Proposal to negotiate a collaboration agreement for the design, testing and prototyping of superconducting elements for the High Luminosity LHC (HL-LHC) project and for the production of spare quadrupole magnets for LHC

    CERN Document Server

    2016-01-01

    Proposal to negotiate a collaboration agreement for the design, testing and prototyping of superconducting elements for the High Luminosity LHC (HL-LHC) project and for the production of spare quadrupole magnets for LHC

  15. Energy Moment Method Applied to Nuclear Quadrupole Splitting of Nuclear Magnetic Resonance Lines

    DEFF Research Database (Denmark)

    Frank, V

    1962-01-01

    Expressions giving the sum of the energy values, raised to the second and third power, for a nucleus interacting with a static magnetic field and a static electric field gradient are derived. Several applications of this method for obtaining the values of the components of the electric field...

  16. Electric quadrupole and magnetic dipole moments of odd nuclei near the magic ones in a self-consistent approach

    CERN Document Server

    Co', G; Anguiano, M; Bernard, R N; Lallena, A M

    2015-01-01

    We present a model which describes the properties of odd-even nuclei with one nucleon more, or less, with respect to the magic number. In addition to the effects related to the unpaired nucleon, we consider those produced by the excitation of the closed shell core. By using a single particle basis generated with Hartree-Fock calculations, we describe the polarization of the doubly magic-core with Random Phase Approximation collective wave functions. In every step of the calculation, and for all the nuclei considered, we use the same finite-range nucleon-nucleon interaction. We apply our model to the evaluation of electric quadrupole and magnetic dipole moments of odd-even nuclei around oxygen, calcium, zirconium, tin and lead isotopes. Our Random Phase Approximation description of the polarization of the core improves the agreement with experimental data with respect to the predictions of the independent particle model. We compare our results with those obtained in first-order perturbation theory, with those ...

  17. Test of Optimized 120-mm LARP $Nb_{3}S_n$ Quadrupole Coil Using Magnetic Mirror Structure

    CERN Document Server

    Chlachidze, G; Andreev, N; Anerella, M; Barzi, E; Bossert, R; Caspi, S; Cheng, D; Dietderich, D; Felice, H; Ferracin, P; Ghosh, A; Godeke, A; Hafalia, A R; Kashikhin, V V; Lamm, M; Marchevsky, M; Nobrega, A; Novitski, I; Orris, D; Sabbi, G L; Schmalzle, J; Wanderer, P; Zlobin, A V

    2013-01-01

    The US LHC accelerator research program (LARP) is developing a new generation of large - aperture high - field quadrupoles based on Nb 3 Sn conductor for the High luminosity upgrade of Large Hadron Collider (HiLumi - LHC). Tests of the first series of 120 - mm aperture HQ coils revealed the necessity for further optimization of the coil design and fabrication process. Modifications in coil design were gradually implemented in two HQ coils previously tested at Fermi National Accelerato r Laboratory (Fermilab) using a magnetic mirror structure (HQM01 and HQM02). This paper describes the construction and test of an HQ mirror model with a coil of optimized design and with an interlayer resistive core in the conductor. The cable for this co il was made of a smaller diameter strand, providing more room for coil expansion during reaction. The 0.8 - mm strand, used in all previous HQ coils was replaced with a 0.778 - mm Nb 3 Sn strand of RRP 108/127 sub - element design. The coil was instrumented with voltage taps, h...

  18. The tuning quadrupole. The first spanish prototype of superconducting magnet to be delivered to CERN. El tuning quadrupole. Primer prototipo espaol de iman superconductor suministrado al CERN

    Energy Technology Data Exchange (ETDEWEB)

    Garcia-Tabares, L.; Cubert, J.M.; Aguirre, P. (CEDEX. Ministerio de Obras Publicas, Transporte y Medio Ambiente (Spain))

    1993-01-01

    The present paper describes the design and manufacturing of the first prototype of superconducting magnet for the future collider LHC to be installed at CERN (Geneva), that was made by Spanish industry with the collaboration of the CEDEX. The main aspects of the magnetic and mechanical calculations are described, as well some items related to the fabrication of the magnet, such as materials, toolings, measurements, etc. Finally all the tests made to the magnet at different stages are mentioned, concluding with the final success of the development. (Author) 4 refs.

  19. CLIC Quadrupole Module final report

    CERN Document Server

    Artoos, K; Mainaud-Durand, H

    2013-01-01

    Future Linear colliders will need particle beam sizes in the nanometre range. The beam also needs to be stable all along the beam line. The CLIC Main Beam Quadrupole (MBQ) module has been defined and studied. It is meant as a test stand for stabilisation and pre-alignment with a MB Quadrupole. The main topic that has been tackled concerns the Quadrupole magnet stabilisation to 1nm at 1Hz. This is needed to obtain the desired CLIC luminosity of 2.1034 cm-2m-1. The deliverable was demonstrated by procuring a MBQ and by stabilising a powered and cooled CLIC MBQ quadrupole. In addition, the stabilisation system has to be compatible with the pre-alignment procedures. Pre-alignment movement resolution has been demonstrated to 1m. The last step is the combined test of stability with a quadrupole on a CLIC Module with the pre-alignment.

  20. Measuring the Magnetic Field Using the Zeeman Effect in Nuclear Quadrupole Resonance of GaSe and InSe Compounds

    Directory of Open Access Journals (Sweden)

    A.P. Samila

    2016-12-01

    Full Text Available Using pulsed nuclear quadrupole resonance method with a fast Fourier transform of the free induction decay signals, the influence of a weak magnetic field (0 ÷ 10 Gauss on NQR spectral lines 69Ga and 115In in layered semiconductors GaSe and InSe was investigated. It has been found that the splitting of resonance lines, caused by the Zeeman effect, can be used to determine the magnitude and direction of the applied magnetic field.

  1. Spectroscopy of f -f transitions, crystal-field calculations, and magnetic and quadrupole helix chirality in DyF e3(BO3) 4

    Science.gov (United States)

    Popova, M. N.; Chukalina, E. P.; Boldyrev, K. N.; Stanislavchuk, T. N.; Malkin, B. Z.; Gudim, I. A.

    2017-03-01

    We present the results of temperature- and polarization-dependent high-resolution optical spectroscopy studies of DyF e3(BO3) 4 performed in spectral ranges 40 -300 c m-1 and 3000 -23 000 c m-1 . The crystal-field (CF) parameters for the D y3 + ions in the P 3121 (P 3221 ) phase of DyF e3(BO3) 4 are obtained from calculations based on the analysis of the measured f-f transitions. Recently, quadrupole helix chirality and its domain structure was observed in resonant x-ray diffraction experiments on DyF e3(BO3) 4 using circularly polarized x rays [T. Usui, Y. Tanaka, H. Nakajima, M. Taguchi, A. Chainani, M. Oura, S. Shin, N. Katayama, H. Sawa, Y. Wakabayashi, and T. Kimura, Nat. Mater. 13, 611 (2014), 10.1038/nmat3942]. Using the obtained set of the CF parameters, we calculate temperature dependencies of the electronic quadrupole moments of the D y3 + ions induced by the low-symmetry (C2) CF component and show that the quadrupole helix chirality can be explained quantitatively. We also consider the temperature dependencies of the bulk magnetic dc-susceptibility and the helix chirality of the single-site magnetic susceptibility tensors of the D y3 + ions in the paramagnetic P 3121 (P 3221 ) phase and suggest the neutron and resonant x-ray diffraction experiments in a magnetic field to reveal the helix chirality of field-induced magnetic moments.

  2. Peptide backbone orientation and dynamics in spider dragline silk and two-photon excitation in nuclear magnetic and quadrupole resonance

    Energy Technology Data Exchange (ETDEWEB)

    Eles, P.T

    2005-07-01

    In the first part of the dissertation, spider dragline silk is studied by solid state NMR techniques. The dependence of NMR frequency on molecular orientation is exploited using the DECODER experiment to determine the orientation of the protein backbone within the silk fibre. Practical experimental considerations require that the silk fibres be wound about a cylindrical axis perpendicular to the external magnetic field, complicating the reconstruction of the underlying orientation distribution and necessitating the development of numerical techniques for this purpose. A two-component model of silk incorporating static b-sheets and polyglycine II helices adequately fits the NMR data and suggests that the b-sheets are well aligned along the silk axis (20 FWHM) while the helices are poorly aligned (68 FWHM). The effects of fibre strain, draw rate and hydration on orientation are measured. Measurements of the time-scale for peptide backbone motion indicate that when wet, a strain-dependent fraction of the poorly aligned component becomes mobile. This suggests a mechanism for the supercontraction of silk involving latent entropic springs that undergo a local strain-dependent phase transition, driving supercontraction. In the second part of this dissertation a novel method is developed for exciting NMR and nuclear quadrupole resonance (NQR) by rf irradiation at multiple frequencies that sum to (or differ by) the resonance frequency. This is fundamentally different than traditional NMR experiments where irradiation is applied on-resonance. With excitation outside the detection bandwidth, two-photon excitation allows for detection of free induction signals during excitation, completely eliminating receiver dead-time. A theoretical approach to describing two-photon excitation is developed based on average Hamiltonian theory. An intuition for two-photon excitation is gained by analogy to the coherent absorption of multiple photons requiring conservation of total energy and

  3. 14N Quadrupole Resonance in the presence of a weak static magnetic field. Direct determination of the electric field gradient tensor

    Science.gov (United States)

    Aissani, Sarra; Guendouz, Laouès; Canet, Daniel

    2014-02-01

    The electric field gradient tensor (considered here at the level of a nitrogen nucleus) can be described by two parameters: the largest element in the (x, y, z) principal axis system, denoted by Vzz, and the asymmetry parameter η=(Vyy-Vxx)/Vzz. The frequencies of the three nitrogen-14 NQR transitions depend on both parameters and two of them are, a priori, necessary for their determination. We demonstrate that, if a weak static magnetic field is applied during a NQR experiment, both parameters can be obtained from a single transition thus alleviating the difficulties for finding out 14N Quadrupole Resonance lines.

  4. Combining magnetic sorting of mother cells and fluctuation tests to analyze genome instability during mitotic cell aging in Saccharomyces cerevisiae.

    Science.gov (United States)

    Patterson, Melissa N; Maxwell, Patrick H

    2014-10-16

    Saccharomyces cerevisiae has been an excellent model system for examining mechanisms and consequences of genome instability. Information gained from this yeast model is relevant to many organisms, including humans, since DNA repair and DNA damage response factors are well conserved across diverse species. However, S. cerevisiae has not yet been used to fully address whether the rate of accumulating mutations changes with increasing replicative (mitotic) age due to technical constraints. For instance, measurements of yeast replicative lifespan through micromanipulation involve very small populations of cells, which prohibit detection of rare mutations. Genetic methods to enrich for mother cells in populations by inducing death of daughter cells have been developed, but population sizes are still limited by the frequency with which random mutations that compromise the selection systems occur. The current protocol takes advantage of magnetic sorting of surface-labeled yeast mother cells to obtain large enough populations of aging mother cells to quantify rare mutations through phenotypic selections. Mutation rates, measured through fluctuation tests, and mutation frequencies are first established for young cells and used to predict the frequency of mutations in mother cells of various replicative ages. Mutation frequencies are then determined for sorted mother cells, and the age of the mother cells is determined using flow cytometry by staining with a fluorescent reagent that detects bud scars formed on their cell surfaces during cell division. Comparison of predicted mutation frequencies based on the number of cell divisions to the frequencies experimentally observed for mother cells of a given replicative age can then identify whether there are age-related changes in the rate of accumulating mutations. Variations of this basic protocol provide the means to investigate the influence of alterations in specific gene functions or specific environmental conditions on

  5. Demonstration of single-shot picosecond time-resolved MeV electron imaging using a compact permanent magnet quadrupole based lens

    CERN Document Server

    Cesar, D; Musumeci, P; Sun, Y; Harrison, J; Frigola, P; O'Shea, F H; To, H; Alesini, D; Li, R K

    2016-01-01

    We present the results of an experiment where a short focal length (~ 1.3 cm) permanent magnet electron lens is used to image micron-size features of a metal sample in a single shot, using an ultra- high brightness ps-long 4 MeV electron beam from a radiofrequency photoinjector. Magnifcation ratios in excess of 30x were obtained using a triplet of compact, small gap (3.5 mm), Halbach-style permanent magnet quadrupoles with nearly 600 T/m field gradients. These results pave the way to- wards single shot time-resolved electron microscopy and open new opportunities in the applications of high brightness electron beams.

  6. Semi classical description of isotropic Non-Heisenberg magnets for spin S=3/2 and linear quadrupole excitation dynamics

    Directory of Open Access Journals (Sweden)

    Y Yousefi

    2012-09-01

    Full Text Available  In this paper, a system with spin S=3/2 with general isotropic nearest neighbor exchange within a mean field approximation possess is discnssed. We derive equations describing non-Heisenberg isotropic model using coherent states of SU(4 group in real parameters and then obtain dispersion equations of spin wave of dipole and quadrupole branches for a small linear excitation from the ground state.

  7. Separation of SSEA-4 and TRA-1-60 labelled undifferentiated human embryonic stem cells from a heterogeneous cell population using magnetic-activated cell sorting (MACS) and fluorescence-activated cell sorting (FACS).

    Science.gov (United States)

    Fong, Chui Yee; Peh, Gary S L; Gauthaman, Kalamegam; Bongso, Ariff

    2009-03-01

    A major concern in human embryonic stem cell (hESC)-derived cell replacement therapy is the risk of tumorigenesis from undifferentiated hESCs residing in the population of hESC-derived cells. Separation of these undifferentiated hESCs from the differentiated derivatives using cell sorting methods may be a plausible approach in overcoming this problem. We therefore explored magnetic activated cell sorting (MACS) and fluorescence activated cell sorting (FACS) to separate labelled undifferentiated hESCs from a heterogeneous population of hESCs and hepatocellular carcinoma cells (HepG2) deliberately mixed respectively at different ratios (10:90, 20:80, 30:70, 40:60 and 50:50) to mimic a standard in vitro differentiation protocol, instead of using a hESC-differentiated cell population, so that we could be sure of the actual number of cells separated. HES-3 and HES-4 cells were labelled in separate experiments for the stem cell markers SSEA-4 and TRA-1-60 using primary antibodies. Anti-PE magnetic microbeads that recognize the PE-conjugated SSEA-4 labelled hESCs was added to the heterogeneous cell mixture and passed through the MACS column. The cells that passed through the column ('flow-through' fraction) and those retained ('labelled' fraction') were subsequently analysed using FACS. The maximum efficacy of hESCs retention using MACS was 81.0 +/- 2.9% (HES-3) and 83.6 +/- 4.2% (HES-4). Using FACS, all the undifferentiated hESCs labelled with the two cell-surface markers could be removed by selective gating. Both hESCs and HepG2 cells in the 'flow-through' fraction following MACS separation were viable in culture whereas by FACS separation only the HepG2 cells were viable. FACS efficiently helps to eliminate the undifferentiated hESCs based on their cell-surface antigens expressed.

  8. ¹⁴N Quadrupole Resonance line broadening due to the earth magnetic field, occuring only in the case of an axially symmetric electric field gradient tensor.

    Science.gov (United States)

    Aissani, Sarra; Guendouz, Laouès; Marande, Pierre-Louis; Canet, Daniel

    2015-01-01

    As demonstrated before, the application of a weak static B0 magnetic field (less than 10 G) may produce definite effects on the ¹⁴N Quadrupole Resonance line when the electric field gradient tensor at the nitrogen nucleus level is of axial symmetry. Here, we address more precisely the problem of the relative orientation of the two magnetic fields (the static field and the radio-frequency field of the pure NQR experiment). For a field of 6G, the evolution of the signal intensity, as a function of this relative orientation, is in very good agreement with the theoretical predictions. There is in particular an intensity loss by a factor of three when going from the parallel configuration to the perpendicular configuration. By contrast, when dealing with a very weak magnetic field (as the earth field, around 0.5 G), this effect drops to ca. 1.5 in the case Hexamethylenetetramine (HMT).This is explained by the fact that the Zeeman shift (due to the very weak magnetic field) becomes comparable to the natural line-width. The latter can therefore be determined by accounting for this competition. Still in the case of HMT, the estimated natural line-width is half the observed line-width. The extra broadening is thus attributed to earth magnetic field. The latter constitutes therefore the main cause of the difference between the natural transverse relaxation time (T₂) and the transverse relaxation time derived from the observed line-width (T₂(⁎)).

  9. Quadrupole Induced Resonant Particle Transport

    Science.gov (United States)

    Gilson, Erik; Fajans, Joel

    1999-11-01

    We have performed experiments that explore the effects of a magnetic quadrupole field on a pure electron plasma confined in a Malmberg-Penning trap. A model that we have developed describes the shape of the plasma and shows that a certain class of resonant particles follows trajectories that take them out of the plasma. Even though the quadrupole field destroys the cylindrical symmetry of the system, our theory predicts that if the electrons are off resonance, then the lifetime of the plasma will not be greatly affected by the quadrupole field. Our preliminary experimental results show that the shape of the plasma and the plasma lifetime agree with our model. We are investigating the scaling of this behavior with various experimental parameters such as the plasma length, density, and strength of the quadrupole field. In addition to being an example of resonant particle transport, this effect may find practical applications in experiments that plan to use magnetic quadrupole neutral atom traps to confine anti-hydrogen created in double-well positron/anti-proton Malmberg-Penning traps. (ATHENA Collaboration.)

  10. Magnetic-activated cell sorting (MACS) can be used as a large-scale method for establishing zebrafish neuronal cell cultures

    OpenAIRE

    Georg Welzel; Daniel Seitz; Stefan Schuster

    2015-01-01

    Neuronal cell cultures offer a crucial tool to mechanistically analyse regeneration in the nervous system. Despite the increasing importance of zebrafish (Danio rerio) as an in vivo model in neurobiological and biomedical research, in vitro approaches to the nervous system are lagging far behind and no method is currently available for establishing enriched neuronal cell cultures. Here we show that magnetic-activated cell sorting (MACS) can be used for the large-scale generation of neuronal-r...

  11. Magnetic-field-induced electric quadrupole moments for relativistic hydrogenlike atoms: Application of the Sturmian expansion of the generalized Dirac-Coulomb Green function

    CERN Document Server

    Stefańska, Patrycja

    2016-01-01

    We consider a Dirac one-electron atom placed in a weak, static, uniform magnetic field. We show that, to the first order in the strength B of the external field, the only electric multipole moments, which are induced by the perturbation in the atom, are those of an even order. Using the Sturmian expansion of the generalized Dirac-Coulomb Green function [R. Szmytkowski, J. Phys. B 30, 825 (1997); 30, 2747(E) (1997)], we derive a closed-form expression for the electric quadrupole moment induced in the atom in an arbitrary discrete energy eigenstate. The result, which has the form of a double finite sum involving the generalized hypergeometric functions 3F2 of the unit argument, agrees with the earlier relativistic formula for that quantity, obtained by us for the ground state of the atom.

  12. Magnetic-field-induced electric quadrupole moments for relativistic hydrogenlike atoms: Application of the Sturmian expansion of the generalized Dirac-Coulomb Green function

    Science.gov (United States)

    Stefańska, Patrycja

    2016-02-01

    We consider a Dirac one-electron atom placed in a weak, static, uniform magnetic field. We show that, to the first order in the strength B of the external field, the only electric multipole moments, which are induced by the perturbation in the atom, are those of an even order. Using the Sturmian expansion of the generalized Dirac-Coulomb Green function [R. Szmytkowski, J. Phys. B 30, 825 (1997), 10.1088/0953-4075/30/4/007; J. Phys. B 30, 2747 (1997), 10.1088/0953-4075/30/11/023], We derive a closed-form expression for the electric quadrupole moment induced in the atom in an arbitrary discrete energy eigenstate. The result, which has the form of a double finite sum involving the generalized hypergeometric functions 3F2 of the unit argument, agrees with the earlier relativistic formula for that quantity, obtained by us for the ground state of the atom.

  13. Antibody-free magnetic cell sorting of genetically modified primary human CD4+ T cells by one-step streptavidin affinity purification.

    Directory of Open Access Journals (Sweden)

    Nicholas J Matheson

    Full Text Available Existing methods for phenotypic selection of genetically modified mammalian cells suffer disadvantages of time, cost and scalability and, where antibodies are used to bind exogenous cell surface markers for magnetic selection, typically yield cells coated with antibody-antigen complexes and beads. To overcome these limitations we have developed a method termed Antibody-Free Magnetic Cell Sorting in which the 38 amino acid Streptavidin Binding Peptide (SBP is displayed at the cell surface by the truncated Low Affinity Nerve Growth Receptor (LNGFRF and used as an affinity tag for one-step selection with streptavidin-conjugated magnetic beads. Cells are released through competition with the naturally occurring vitamin biotin, free of either beads or antibody-antigen complexes and ready for culture or use in downstream applications. Antibody-Free Magnetic Cell Sorting is a rapid, cost-effective, scalable method of magnetic selection applicable to either viral transduction or transient transfection of cell lines or primary cells. We have optimised the system for enrichment of primary human CD4+ T cells expressing shRNAs and exogenous genes of interest to purities of >99%, and used it to isolate cells following Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR/Cas9 genome editing.

  14. Magnetic and superconducting properties of a heavy-fermion CeCoIn5 epitaxial film probed by nuclear quadrupole resonance

    Science.gov (United States)

    Yamanaka, Takayoshi; Shimozawa, Masaaki; Shishido, Hiroaki; Kitagawa, Shunsaku; Ikeda, Hiroaki; Shibauchi, Takasada; Terashima, Takahito; Matsuda, Yuji; Ishida, Kenji

    2017-08-01

    Since the progress in the fabrication techniques of thin films of exotic materials such as strongly correlated heavy-fermion compounds, microscopic studies of the magnetic and electronic properties inside the films have been needed. Herein, we report the observation of 115In nuclear quadrupole resonance (NQR) in an epitaxial film of the heavy-fermion superconductor CeCoIn5, for which the microscopic field gradient within the unit cell as well as magnetic and superconducting properties at zero field are evaluated. We find that the nuclear spin-lattice relaxation rate in the film is in excellent agreement with that of bulk crystals, whereas the NQR spectra show noticeable shifts and significant broadening indicating a change in the electric-field distribution inside the film. The analysis implies a displacement of In layers in the film, which, however, does not affect the magnetic fluctuations and superconducting pairing. This implies that inhomogeneity of the electronic field gradient in the film sample causes no pair-breaking effect.

  15. Magnetic Dipole and Electric Quadrupole Transitions in the Trivalent Lanthanide Series: Calculated Emission Rates and Oscillator Strengths

    CERN Document Server

    Dodson, Christopher M

    2012-01-01

    Given growing interest in optical-frequency magnetic dipole transitions, we use intermediate coupling calculations to identify strong magnetic dipole emission lines that are well suited for experimental study. The energy levels for all trivalent lanthanide ions in the 4fn configuration are calculated using a detailed free ion Hamiltonian, including electrostatic and spin-orbit terms as well as two-body, three-body, spin-spin, spin-other-orbit, and electrostatically correlated spin-orbit interactions. These free ion energy levels and eigenstates are then used to calculate the oscillator strengths for all ground-state magnetic dipole absorption lines and the spontaneous emission rates for all magnetic dipole emission lines including transitions between excited states. A large number of strong magnetic dipole transitions are predicted throughout the visible and near-infrared spectrum, including many at longer wavelengths that would be ideal for experimental investigation of magnetic light-matter interactions wit...

  16. Fermilab Tevatron quadrupoles

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, W.E.; Fisk, H.E.; Gross, D.A.; Lundy, R.A.; Schmidt, E.E.; Turkot, F.

    1983-03-01

    Details on the design, construction, and performance tests of Energy Saver/Doubler quadrupoles are presented along with recent data from the test of a special high gradient low beta prototype quadrupole.

  17. CLIC Main Beam Quadrupole Eigen Mode computation

    CERN Document Server

    Deleglise, Guillaume

    2010-01-01

    In this report, we summarise the work done on the CLIC Main Beam Quadrupole. There are about 4000 MB quadrupoles of 4 types with lengths ranging from 420mm to 1900mm. In order to obtain the desired CLIC luminosity, the MB quadrupoles have to be stable to 1nm above 1Hz. The region of interest for the study is between 0.5Hz and about 100Hz. In order to achieve the specifications, the magnet should not have any resonance peaks in this region of Interest. In addition, the magnet on its support shouldn’t have any resonance peak in the same frequency range. The first step is to determine if the designed magnet has its first resonance peak above 100Hz. We are studying the longest quadrupole more susceptible to internal resonances. In a second step, the magnet on ideal supporting points has been evaluated. The current magnet design can be seen on following figure. One can see that it is composed of 4 quadrants assembled so as to have a quadrupole magnetic field. As a last step, the mechanical model has been used to...

  18. AA, wide quadrupole on measurement stand

    CERN Multimedia

    CERN PhotoLab

    1981-01-01

    Please look up 8101024 first. Shims and washers on the wide quadrupoles (QFW, QDW; located in the lattice where dispersion was large) served mostly for corrections of those lattice parameters which were a function of momentum. After mounting shims and washers, the quadrupoles were measured to determine their magnetic centre and to catalogue the effect of washer constellations. Raymond Brown is busy measuring a wide quad.

  19. LCLS Undulator Quadrupole Fiducialization Plan

    Energy Technology Data Exchange (ETDEWEB)

    Wolf, Zachary; Levashov, Michael; Lundahl, Eric; Reese, Ed; LeCocq, Catherine; Ruland, Robert; /SLAC

    2010-11-24

    This note presents the fiducialization plan for the LCLS undulator quadrupoles. The note begins by summarizing the requirements for the fiducialization. A discussion of the measurement equipment is presented, followed by the methods used to perform the fiducialization and check the results. This is followed by the detailed fiducialization plan in which each step is enumerated. Finally, the measurement results and data storage formats are presented. The LCLS is made up of 33 assemblies consisting of an undulator, quadrupole, beam finder wire, and other components mounted on a girder. The components must be mounted in such a way that the beam passes down the axis of each component. In this note, we describe how the ideal beam axis is related to tooling balls on the quadrupole. This step, called fiducialization, is necessary because the ideal beam axis is determined magnetically, whereas tangible objects must be used to locate the quadrupole. The note begins with the list of fiducialization requirements. The laboratory in which the work will be performed and the relevant equipment is then briefly described. This is followed by a discussion of the methods used to perform the fiducialization and the methods used to check the results. A detailed fiducialization plan is presented in which all the steps of fiducialization are enumerated. A discussion of the resulting data files and directory structure concludes the note.

  20. Magnetic-dipole-to-electric-quadrupole cross-susceptibilities for relativistic hydrogenlike atoms in some low-lying discrete energy eigenstates

    CERN Document Server

    Stefańska, Patrycja

    2016-01-01

    In this paper we present tabulated data for magnetic-dipole-to-electric-quadrupole cross-susceptibilities ($\\chi_{\\textrm{M}1 \\to \\textrm{E}2}$) for Dirac one-electron atoms with a pointlike, spinless and motionless nucleus of charge $Ze$. Numerical values of this susceptibility for the hydrogen atom ($Z=1$) and for hydrogenic ions with $2 \\leqslant Z \\leqslant 137$ are computed from the general analytical formula, recently derived by us [P. Stefa{\\'n}ska, Phys. Rev. A 93 (2016) 022504], valid for an arbitrary discrete energy eigenstate. In this work we provide 30 tables with the values of $\\chi_{\\textrm{M}1 \\to \\textrm{E}2}$ for the ground state, and also for the first, the second and the third set of excited states (i.e.: 2s$_{1/2}$, 2p$_{1/2}$, 2p$_{3/2}$, 3s$_{1/2}$, 3p$_{1/2}$, 3p$_{3/2}$, 3d$_{3/2}$, 3d$_{5/2}$, 4s$_{1/2}$, 4p$_{1/2}$, 4p$_{3/2}$, 4d$_{3/2}$, 4d$_{5/2}$, 4f$_{5/2}$ and 4f$_{7/2}$) of the relativistic hydrogenlike atoms. The value of the inverse of the fine-structure constant used in the...

  1. A modified Rogowski coil for measurements of hybrid permanent magnets

    Energy Technology Data Exchange (ETDEWEB)

    Bertsche, K.

    1996-08-01

    For large permanent magnets, as proposed for the Fermilab Recycler Ring, it may be important to quickly verify that the magnet`s strength is correct. This may be important, for example, if a magnet is suspected of having changed due to some sort of accident. The field strength of a pure dipole can be readily measured with a Hall probe, but for indexed dipoles and for quadrupoles a Hall probe will not give very accurate results without precise positioning. We have investigated a different approach, the use of a modified Rogowski coil to measure the magnetic potential of each pole. As long as magnet geometry is fixed and known, measurement of the magnetic potential at each pole gives a good measurement of field strength even for magnets with large quadrupole components. The construction and use of such a coil and the precision of measurements made with it will be discussed. 4 refs., 5 figs.

  2. AA, wide quadrupole on measurement stand

    CERN Multimedia

    CERN PhotoLab

    1981-01-01

    Please look up 8101024 and 8103203 first. Wide quadrupole (QFW, QDW) with end-shims and shimming washers on the measurement stand. With the measurement coil one measured the harmonics of the magnetic field, determined the magnetic centre, and catalogued the effect of washer constellations.

  3. MQXFS1 Quadrupole Fabrication Report

    Energy Technology Data Exchange (ETDEWEB)

    Ambrosio, G.; et al.

    2017-07-16

    This report presents the fabrication and QC data of MQXFS1, the first short model of the low-beta quadrupoles (MQXF) for the LHC High Luminosity Upgrade. It describes the conductor, the coils, and the structure that make the MQXFS1 magnet. Qualification tests and non-conformities are also presented and discussed. The fabrication of MQXFS1 was started before the finalization of conductor and coil design for MQXF magnets. Two strand design were used (RRP 108/127 and RRP 132/169). Cable and coil cross-sections were “first generation”.

  4. Sorting choanoflagellates

    Science.gov (United States)

    Marconi, Veronica I.; Miño, Gaston L.; Sparacino, Javier; Banchio, Adolfo J.; Condat, Carlos A.; Koehl, Mimi A. R.; King, Nicole; Stocker, Roman

    2015-03-01

    In freshwater environments, as well as in oceans, environmental conditions are in constant fluctuation. Some heterotrophic plankton must adapt their swimming behavior in order to survive under these conditions. In the case of the choanoflagellate, the closest animal ancestor, the ability to forage for food is given not only by its single flagellum, but also by its differentiation between fast and slow swimmers. The understanding of how these cells with different strategies to swim search for food can give us a better insight into how eukaryotes respond to different stimuli. In this work, we have designed a microfluidic device that sorts choanoflagellates by their speed. The optimal geometry was found by a numerical model using the experimentally determined motilities of each swimmer type.

  5. AA, shims and washers on quadrupole ends

    CERN Multimedia

    CERN PhotoLab

    1981-01-01

    Due to the fact that much of the field of the quadrupoles was outside the iron (in particular with the wide quadrupoles) and that thus the fields of quadrupoles and bending magnets interacted, the lattice properties of the AA could not be predicted with the required accuracy. After a first running period in 1980, during which detailed measurements were made with proton test beams, corrections to the quadrupoles were made in 1981, in the form of laminated shims at the ends of the poles, and with steel washers. With the latter ones, further refinements were made in an iterative procedure with measurements on the circulating beam. This eventually resulted, amongst other things, in a very low chromaticity, with the Q-values being constant to within +- 0.001 over the total momentum range of 6 %. Here we see the shims and washers on a narrow qudrupole (QFN, QDN). See also 8103203, 8103204, 8103205, 8103206.

  6. SUPERCONDUCTING QUADRUPOLE ARRAYS FOR MULTIPLE BEAM TRANSPORT

    Energy Technology Data Exchange (ETDEWEB)

    Rainer Meinke

    2003-10-01

    The goal of this research was to develop concepts for affordable, fully functional arrays of superconducting quadrupoles for multi-beam transport and focusing in heavy ion fusion (HIF)accelerators. Previous studies by the Virtual National Laboratory (VNL) collaboration have shown that the multi-beam transport system (consisting of alternating gradient quadrupole magnets, a beam vacuum system, and the beam monitor and control system) will likely be one of the most expensive and critical parts of such an accelerator. This statement is true for near-term fusion research accelerators as well as accelerators for the ultimate goal of power production via inertial fusion. For this reason, research on superconducting quadrupole arrays is both timely and important for the inertial fusion energy (IFE) research program. This research will also benefit near-term heavy ion fusion facilities such as the Integrated Research Experiment (IRE)and/or the Integrated Beam Experiment (IBX). We considered a 2-prong approach that addresses the needs of both the nearer and longer term requirements of the inertial fusion program. First, we studied the flat coil quadrupole design that was developed by LLNL; this magnet is 150 mm long with a 50 mm aperture and thus is suitable for near term experiments that require magnets of a small length to aperture ratio. Secondly, we studied the novel double-helix quadrupole (DHQ) design in a small (3 x 3) array configuration; this design can provide an important step to the longer term solution of low-cost, easy to manufacture array constructions. Our Phase I studies were performed using the AMPERES magnetostatic analysis software. Consideration of these results led to plans for future magnet R&D construction projects. The first objective of Phase I was to develop the concept of a superconducting focusing array that meets the specific requirements of a heavy ion fusion accelerator. Detailed parameter studies for such quadrupole arrays were performed

  7. Preparation of myeloid derived suppressor cells (MDSC) from naive and pancreatic tumor-bearing mice using flow cytometry and automated magnetic activated cell sorting (AutoMACS).

    Science.gov (United States)

    Nelson, Nadine; Szekeres, Karoly; Cooper, Denise; Ghansah, Tomar

    2012-06-18

    sieve. Splenocytes are then Red Blood Cell (RBC) lysed and an aliquot of these leukocytes are stained using fluorochrome-conjugated antibodies against Mac-1 and Gr-1 to immunophenotype MDSC percentages using Flow Cytometry. In a parallel experiment, whole leukocytes from naïve mice are stained with fluorescent-conjugated Gr-1 antibodies, incubated with PE-MicroBeads and positively selected using an automated Magnetic Activated Cell Sorting (autoMACS) Pro Separator. Next, an aliquot of Gr-1(+) leukocytes are stained with Mac-1 antibodies to identify the increase in MDSC percentages using Flow Cytometry. Now, these Gr1(+) enriched leukocytes are ready for FACS sorting of MDSC to be used in comparative analyses (naïve vs. tumor- bearing) in in vivo and in vitro assays.

  8. Efficient Pulsed Quadrupole

    CERN Document Server

    Petzenhauser, I.; Spiller, P.; Tenholt, C.

    2016-01-01

    In order to raise the focusing gradient in case of bunched beam lines, a pulsed quadrupole was designed. The transfer channels between synchrotrons as well as the final focusing for the target line are possible applications. The quadrupole is running in a pulsed mode, which means an immense saving of energy by avoiding standby operation. Still the high gradients demand high currents. Hence a circuit had to be developed which is able to recover a significant amount of the pulsing energy for following shots. The basic design of the electrical circuit of the quadrupole is introduced. Furthermore more energy efficient circuits are presented and the limits of adaptability are considered.

  9. All systems go for LHC quadrupoles

    CERN Multimedia

    2003-01-01

    The series fabrication of the Main Quadrupole cold masses for the LHC has begun with the delivery of the first unit on February 12th. The superconducting dipole magnets required to bend the proton beams around the LHC are often in the news. Less famous, perhaps, but equally important are the 360 main quadrupole (MQ) magnets, which will perform the principal focusing around the 27 km ring. CERN and CEA-Saclay began collaborating on the development and prototyping of these magnets in 1989. This resulted in five highly successful quadrupole units - also known as short straight sections - one of which was integrated for testing in String 1, and two others of the final design in String 2. Once the tests had confirmed the validity of the design and realization, the fabrication of the 360 cold masses had to be transferred to industry. After highly competitive tendering, the German firm ACCEL Instruments was entrusted both with the construction of the quadrupole magnets themselves, and with their assembly into the co...

  10. Isolation and Characterization of Anti-SEB Peptides Using Magnetic Sorting and Bacterial Peptide Display Library Technology

    Science.gov (United States)

    2012-09-01

    NMWL) dialysis membrane. The magnetic bead-SEB conjugate was prepared using Magnabind Carboxyl Derivatized Beads (Thermo Scientific) according to...W. G. Roessler, J. Wagman et al., “ Purification of Staphylococcal Enterotoxin B,” Biochemistry, 4(6), 1011-& (1965). [12] J. J. Iandolo, and R. K...Tweten, “ Purification of Staphylococcal Enterotoxins,” Methods in Enzymology, 165, 43-52 (1988). [13] J. J. Rice, and P. S. Daugherty, “Directed

  11. k -Bitonic sort

    Institute of Scientific and Technical Information of China (English)

    高庆狮; 胡玥; 刘志勇

    1999-01-01

    A k-bitonic sort which generalizes the bitonic sort is proposed. The theorem of the bitonic sort, which merges two monotonic sequences into one order sequence, is extended into the theorem of k-bitonic sort. The k-bitonic sort merges K (=2k or 2k-1) monotonic sequences into one order sequence in steps, where k=[K/2] is an integer and k≥1. The k-bitonic sort is the Batcher’s bitonic sort when k=1.

  12. Development of Superconducting Focusing Quadrupoles for Heavy Ion Drivers

    Energy Technology Data Exchange (ETDEWEB)

    Martovetsky, N; Manahan, R; Lietzke, A F

    2001-09-10

    Heavy Ion Fusion (HIF) is exploring a promising path to a practical inertial-confinement fusion reactor. The associated heavy ion driver will require a large number of focusing quadrupole magnets. A concept for a superconducting quadrupole array, using many simple racetrack coils, was developed at LLNL. Two, single-bore quadrupole prototypes of the same design, with distinctly different conductor, were designed, built, and tested. Both prototypes reached their short sample currents with little or no training. Magnet design, and test results, are presented and discussed.

  13. Magnetic-activated cell sorting of TCR-engineered T cells, using tCD34 as a gene marker, but not peptide-MHC multimers, results in significant numbers of functional CD4+ and CD8+ T cells.

    Science.gov (United States)

    Govers, Coen; Berrevoets, Cor; Treffers-Westerlaken, Elike; Broertjes, Marieke; Debets, Reno

    2012-06-01

    T cell-sorting technologies with peptide-MHC multimers or antibodies against gene markers enable enrichment of antigen-specific T cells and are expected to enhance the therapeutic efficacy of clinical T cell therapy. However, a direct comparison between sorting reagents for their ability to enrich T cells is lacking. Here, we compared the in vitro properties of primary human T cells gene-engineered with gp100(280-288)/HLA-A2-specific T cell receptor-αβ (TCRαβ) on magnetic-activated cell sorting (MACS) with various peptide-MHC multimers or an antibody against truncated CD34 (tCD34). With respect to peptide-MHC multimers, we observed that Streptamer(®), when compared with pentamers and tetramers, improved T cell yield as well as level and stability of enrichment, of TCR-engineered T cells (>65% of peptide-MHC-binding T cells, stable for at least 6 weeks). In agreement with these findings, Streptamer, the only detachable reagent, revealed significant T cell expansion in the first week after MACS. Sorting TCR and tCD34 gene-engineered T cells with CD34 monoclonal antibody (mAb) resulted in the most significant T cell yield and enrichment of T cells (>95% of tCD34 T cells, stable for at least 6 weeks). Notably, T cells sorted with CD34 mAb, when compared with Streptamer, bound about 2- to 3-fold less peptide-MHC but showed superior antigen-specific upregulated expression of CD107a and production of interferon (IFN)-γ. Multiparametric flow cytometry revealed that CD4(+) T cells, uniquely present in CD34 mAb-sorted T cells, contributed to enhanced IFN-γ production. Taken together, we postulate that CD34 mAb-based sorting of gene-marked T cells has benefits toward applications of T cell therapy, especially those that require CD4(+) T cells.

  14. Comparison The Effects of Two Monocyte Isolation Methods,Plastic Adherence and Magnetic Activated Cell Sorting Methods,on Phagocytic Activity of Generated Dendritic Cells

    Directory of Open Access Journals (Sweden)

    Behnaz Asadi

    2013-01-01

    Full Text Available Objective: It is believed that monocyte isolation methods and maturation factors affect the phenotypic and functional characteristics of resultant dendritic cells (DC. In the present study, we compared two monocyte isolation methods, including plastic adherence-dendritic cells (Adh-DC and magnetic activated cell sorting- dendritic cells (MACS-DC, and their effects on phagocytic activity of differentiated immature DCs (immDCs.Materials and Methods: In this experimental study, immDCs were generated from plastic adherence and MACS isolated monocytes in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF and interleukin 4 (IL-4 in five days. The phagocytic activity of immDCs was analyzed by fluorescein isothiocyanate (FITC-conjugated latex bead using flow cytometry. One way ANOVA test was used for statistical analysis of differences among experimental groups, including Adh-DC and MACS-DC groups.Results: We found that phagocytic activity of Adh-DC was higher than MACS-DC, whereas the mean fluorescence intensity (MFI of phagocytic cells was higher in MACS-DC (p<0.05.Conclusion: We concluded that it would be important to consider phagocytosis parameters of generated DCs before making any decision about monocyte isolation methods to have fully functional DCs.

  15. Enrichment of fetal cells from maternal blood by high gradient magnetic cell sorting (double MACS) for PCR-based genetic analysis.

    Science.gov (United States)

    Büsch, J; Huber, P; Pflüger, E; Miltenyi, S; Holtz, J; Radbruch, A

    1994-12-01

    For simple and effective isolation of fetal cells from peripheral maternal blood, we combined depletion of maternal cells and enrichment of fetal cells by high-gradient magnetic cell separation (MACS). First CD45+ and CD14+ cells were depleted from maternal peripheral blood mononuclear cells by MACS. From the depleted fraction, CD71+ erythroid cells were enriched up to 80 per cent by MACS. This double-MACS' procedure yielded an average depletion rate of 780-fold and an average enrichment rate of 500-fold, with approximate recovery rates of 40-55 per cent. For paternity testing, cells from unseparated blood and the various fractions were analysed for polymorphism of the HLA-DQ-A1 locus and D1S80 locus by the polymerase chain reaction (PCR). In CD45-/CD71+ sorted cells from maternal blood, but not in unfractionated cells from maternal blood or CD45-/CD14- cells, paternal alleles could be detected. In the CD45-/CD71+ fraction, the relative frequency of paternal alleles compared with maternal alleles ranged from 1 in 20 to 1 in 200 (determined by titration and depending on the quality of separation and biological variation). In 7 out of 11 cases, between weeks 12 and 25 of gestation, we could identify paternal alleles by PCR, either HLA-DQ-A1 or D1S80. This double-MACS procedure is simple, fast, efficient, and reliable for non-invasive prenatal diagnosis.

  16. Isolation, purification, culture and characterisation of myoepithelial cells from normal and neoplastic canine mammary glands using a magnetic-activated cell sorting separation system.

    Science.gov (United States)

    Sánchez-Céspedes, R; Maniscalco, L; Iussich, S; Martignani, E; Guil-Luna, S; De Maria, R; Martín de Las Mulas, J; Millán, Y

    2013-08-01

    Mammary gland tumours, the most common malignant neoplasm in bitches, often display myoepithelial (ME) cell proliferation. The aim of this study was to isolate, purify, culture and characterise ME cells from normal and neoplastic canine mammary glands. Monodispersed cells from three normal canine mammary glands and five canine mammary tumours were incubated with an anti-Thy1 antibody and isolated by magnetic-activated cell sorting (MACS). Cells isolated from two normal glands (cell lines CmME-N1 and CmME-N2) and four tumours (cell lines CmME-K1 from a complex carcinoma, CmME-K2 from a simple tubulopapillary carcinoma, and CmME-K3 and CmME-K4 from two carcinomas within benign tumours) were cultured in supplemented DMEM/F12 media for 40days. Cell purity was >90%. Tumour-derived ME cell lines exhibited heterogeneous morphology, growth patterns and immunocytochemical expression of cytokeratins, whereas cell lines from normal glands retained their morphology and levels of cytokeratin expression during culture. Cell lines from normal glands and carcinomas within benign tumours grew more slowly than those from simple and complex carcinomas. This methodology has the potential to be used for in vitro analysis of the role of ME cells in the growth and progression of canine mammary tumours.

  17. Magnetic activated cell sorting: an effective method for reduction of sperm DNA fragmentation in varicocele men prior to assisted reproductive techniques.

    Science.gov (United States)

    Degheidy, T; Abdelfattah, H; Seif, A; Albuz, F K; Gazi, S; Abbas, S

    2015-10-01

    Semen parameters of varicocele men have been usually suspected to exhibit higher levels of abnormalities including DNA fragmentation, reactive oxygen species (ROS) and apoptotic markers. Negative correlation between increased level of DNA fragmentation and assisted reproductive techniques (ART) outcome has been studied by several authors. In the current study, we aim to evaluate the possible value of magnetic activated cell sorting (MACs) technology in reduction of DNA fragmentation in infertile varicocele patients prior to ART. Semen samples, collected from 36 varicocele patients, were prepared by density gradient centrifugation (DGC). Every sample was subsequently divided into two aliquots. One aliquot was kept untouched as pre-MACs control while the other aliquot was subjected to MACs technique, for depletion of apoptotic spermatozoa, and serves as post-MACs test. Sperm count, motility and DNA fragmentations were evaluated for both control and test samples. Post-MACs samples showed no deleterious reduction in total sperm motility (80.64 ± 6.97%) compared with control samples (80.97 ± 7.74%) while sperm DNA fragmentations were significantly reduced in post-MACs samples (9.61 ± 5.62%) compared with pre-MACs controls (12.43 ± 6.29%) (P DNA fragmentation in infertile varicocele patients prior to ART. © 2014 Blackwell Verlag GmbH.

  18. Isolation of myeloid-derived suppressor cells subsets from spleens of orthotopic liver cancer-bearing mice by fluorescent-activated and magnetic-activated cell sorting: similarities and differences.

    Science.gov (United States)

    Xu, Yaping; Zhao, Wenxiu; Wu, Duan; Xu, Jianfeng; Lin, Suqiong; Tang, Kai; Yin, Zhenyu; Wang, Xiaomin

    2014-01-01

    Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that commonly expand during tumor development and that play a critical role in suppression of immune responses. MDSCs can be classified into two groups: Mo-MDSCs and G-MDSCs. These cells differ in their morphology, phenotype, differentiation ability, and immunosuppressive activity, and inhibit immune responses via different mechanisms. Therefore, identifying an effective method for isolating viable Mo-MDSCs and G-MDSCs is important. Here, we demonstrated the differences and similarities between fluorescence-activated cell sorting (FACS) and magnetic-activated cell sorting (MACS) in sorting G-MDSCs and Mo-MDSCs. Both MACS and FACS could obtain G-MDSCs and Mo-MDSCs with high viability and purity. A high yield and purity of G-MDSCs could be obtained both by using FACS and MACS, because G-MDSCs are highly expressed in the spleen of tumor-bearing mice. However, Mo-MDSCs, which comprise a small population among leukocytes, when sorted by MACS, could be obtained at much greater cell number, although with a slightly lower purity, than when sorted by FACS. In conclusion, we recommended using both FACS and MACS for isolating G-MDSCs, and using MACS for isolation of Mo-MDSCs.

  19. What is a Sorting Function?

    DEFF Research Database (Denmark)

    Henglein, Fritz

    2009-01-01

    What is a sorting function—not a sorting function for a given ordering relation, but a sorting function with nothing given? Formulating four basic properties of sorting algorithms as defining requirements, we arrive at intrinsic notions of sorting and stable sorting: A function is a sorting...

  20. Low-frequency quadrupole impedance of undulators and wigglers

    Science.gov (United States)

    Blednykh, A.; Bassi, G.; Hidaka, Y.; Smaluk, V.; Stupakov, G.

    2016-10-01

    An analytical expression of the low-frequency quadrupole impedance for undulators and wigglers is derived and benchmarked against beam-based impedance measurements done at the 3 GeV NSLS-II storage ring. The adopted theoretical model, valid for an arbitrary number of electromagnetic layers with parallel geometry, allows to calculate the quadrupole impedance for arbitrary values of the magnetic permeability μr . In the comparison of the analytical results with the measurements for variable magnet gaps, two limit cases of the permeability have been studied: the case of perfect magnets (μr→∞ ), and the case in which the magnets are fully saturated (μr=1 ).

  1. Development of superconducting quadrupole magnets for beam-interaction region at CERN-LHC (11). Field quality of the third 1m model magnets with new design; CERN-LHC bimu sonyuyo shikyoku chodendo magunetto no kaihatsu (11). Shin dezain 1m moderu magunetto ni okeru jiba tokusei

    Energy Technology Data Exchange (ETDEWEB)

    Ouchi, N.; Ajima, Y.; Ogitsu, T.; Roger, R.; Tsuchiya, K.; Yamamoto, A.; Shintomi, T. [High Energy Accelerator Research Organization, Tsukuba (Japan)

    2000-05-29

    In the high-energy accelerator research aircraft construction, it develops beam last convergence superconductivity quadrupoles electromagnet used by the CERN-LHC accelerator in CERN and cooperation. It requires the thing that the magnetic field gradient in the operation of this electromagnet is very high with 215T/m and that the accuracy is also high on the uniformity of the magnetic field. It had manufactured 2 magnets until now, and it carried out the magnetic field measurement. From this result, it was confirmed that there was the necessity of the improvement in the 20 pole components, and it designed the new magnet cross-sectional shape, and it manufactured the No.3 machine. In this report, magnetic field measurement result of this No.3 machine is reported. (NEDO)

  2. ISR "Terwilliger" Quadrupole

    CERN Multimedia

    1983-01-01

    There were 48 of these Quadrupoles in the ISR. They were distributed around the rings according to the so-called Terwilliger scheme. Their aperture was 184 mm, their core length 300 mm, their gradient 5 T/m. Due to their small length as compared to the aperture, the end fringe field errors had to be compensated by suitably shaping the poles.

  3. ISR Superconducting Quadrupoles

    CERN Multimedia

    1977-01-01

    Michel Bouvier is preparing for curing the 6-pole superconducting windings inbedded in the cylindrical wall separating liquid helium from vacuum in the quadrupole aperture. The heat for curing the epoxy glue was provided by a ramp of infrared lamps which can be seen above the slowly rotating cylinder. See also 7703512X, 7702690X.

  4. Parallel sorting algorithms

    CERN Document Server

    Akl, Selim G

    1985-01-01

    Parallel Sorting Algorithms explains how to use parallel algorithms to sort a sequence of items on a variety of parallel computers. The book reviews the sorting problem, the parallel models of computation, parallel algorithms, and the lower bounds on the parallel sorting problems. The text also presents twenty different algorithms, such as linear arrays, mesh-connected computers, cube-connected computers. Another example where algorithm can be applied is on the shared-memory SIMD (single instruction stream multiple data stream) computers in which the whole sequence to be sorted can fit in the

  5. LARP Long Nb3Sn Quadrupole Design.

    Energy Technology Data Exchange (ETDEWEB)

    Ambrosio,G.; Andreev, N.; Anerella, M.; Barzi, E.; Bossert, R.; Caspi, S.; Chlachidize, G.; Dietderich, D.; Feher, S.; Felice, H.; Ferracin, P.; Ghosh, A.; Hafalia, A.R.; Hannaford, C.R.; Kashikhin, V.V.; Kerby, J.; Lamm, M.; Lietzke, A.; McInturff, A.; Muratore, J.; Nobrega, F.; Novitsky, I.; Sabbi, G.L.; Schmalzle, J.; Tartaglia, M.; Turrioni, D.; Wanderer, P.; Whitson, G.; Zlobin, A.V.

    2007-08-27

    A major milestone for the LHC Accelerator Research Program (LARP) is the test, by the end of 2009, of two 4m-long quadrupole magnets (LQ) wound with Nb{sub 3}Sn conductor. The goal of these magnets is to be a proof of principle that Nb{sub 3}Sn is a viable technology for a possible LHC luminosity upgrade. The design of the LQ is based on the design of the LARP Technological Quadrupoles, presently under development at FNAL and LBNL, with 90-mm aperture and gradient higher than 200 T/m. The design of the first LQ model will be completed by the end of 2007 with the selection of a mechanical design. In this paper we present the coil design addressing some fabrication technology issues, the quench protection study, and three designs of the support structure.

  6. Emission of nuclear quadrupole resonance from polycrystalline hexamethylenetetramine.

    Science.gov (United States)

    Ota, G; Itozaki, H

    2008-03-01

    The angular dependence of the nuclear quadrupole resonance (NQR) signal intensity emitted from polycrystalline hexamethylenetetramine has been analytically investigated for all directions for non-contact detection of chemicals by nuclear quadrupole resonance. The field pattern of the NQR signal from a column sample was measured. The emitted patterns were the same as that from a united single magnetic dipole, which fitted well to the estimation based on quadrupole principle axis system. This result is helpful to design an antenna for NQR remote detection.

  7. Efficient isolation of sperm with high DNA integrity and stable chromatin packaging by a combination of density-gradient centrifugation and magnetic-activated cell sorting.

    Science.gov (United States)

    Chi, Hee-Jun; Kwak, Su-Jin; Kim, Seok-Gi; Kim, Youn-Young; Park, Ji-Young; Yoo, Chang-Seok; Park, Il-Hae; Sun, Hong-Gil; Kim, Jae-Won; Lee, Kyeong-Ho

    2016-12-01

    This study was carried out to investigate the correlations of the sperm DNA fragmentation index (DFI) with semen parameters and apoptosis, and to investigate the effects of density-gradient centrifugation (DGC) and magnetic-activated cell sorting (MACS) on reducing the proportion of sperm with DNA fragmentation and protamine deficiency. Semen analysis and a sperm DNA fragmentation assay were performed to assess the correlations between semen parameters and the DFI in 458 semen samples. Sperm with progressive motility or non-apoptosis were isolated by DGC or MACS, respectively, in 29 normozoospermic semen samples. The effects of DGC or MACS alone and of DGC and MACS combined on reducing the amount of sperm in the sample with DNA fragmentation and protamine deficiency were investigated. The sperm DFI showed a significant correlation (r=-0.347, p<0.001) with sperm motility and morphology (r=-0.114, p<0.05) but not with other semen parameters. The DFI (11.5%±2.0%) of semen samples was significantly reduced by DGC (8.1%±4.1%) or MACS alone (7.4%±3.9%) (p<0.05). The DFI was significantly further reduced by a combination of DGC and MACS (4.1%±1.3%, p<0.05). Moreover, the combination of DGC and MACS (1.6%±1.1%, p<0.05) significantly reduced the protamine deficiency rate of semen samples compared to DGC (4.4%±3.2%) or MACS alone (3.4%±2.2%). The combination of DGC and MACS may be an effective method to isolate high-quality sperm with progressive motility, non-apoptosis, high DNA integrity, and low protamine deficiency in clinical use.

  8. Quadrupole collectivity with isospin

    Energy Technology Data Exchange (ETDEWEB)

    Ginocchio, J.N.; Leviatan, A. (Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States) Racah Institute of Physics, The Hebrew University, Jerusalem 91904 (Israel))

    1994-10-03

    We study intrinsic aspects of quadrupole collectivity with conserved isospin in the framework of the interacting boson model (IBM-3) of nuclei. A geometric visualization is achieved by means of a novel type of intrinsic states which are deformed in angular momentum yet have well defined isospin. The energy surface of the general IBM-3 Hamiltonian is derived and normal modes are identified for prolate deformations.

  9. Extension of the Measurement Capabilities of the Quadrupole Resonator

    CERN Document Server

    Junginger, Tobias; Welsch, Carsten

    2012-01-01

    The Quadrupole Resonator, designed to measure the surface resistance of superconducting samples at 400 MHz has been refurbished. The accuracy of its RF-DC compensation measurement technique is tested by an independent method. It is shown that the device enables also measurements at 800 and 1200 MHz and is capable to probe the critical RF magnetic field. The electric and magnetic field configuration of the Quadrupole Resonator are dependent on the excited mode. It is shown how this can be used to distinguish between electric and magnetic losses.

  10. The winding and testing of a 10 cm superconductive quadrupole for CERN

    CERN Document Server

    Williams, J.E.C.; Cornish, D.N.

    1970-01-01

    The construction and testing of the first of a pair of quadrupole magnets, designed for use as superconductive beam handling elements at CERN, is described. Tests showed this magnet to be eminently suitable for nuclear physics applications.

  11. Recent advances in flow cytometric cell sorting.

    Science.gov (United States)

    Osborne, Geoffrey W

    2011-01-01

    The classification and separation of one cell type or particle from others is a fundamental task in many areas of science. Numerous techniques are available to perform this task; however, electrostatic cell sorting has gained eminence over others because, when combined with the analysis capabilities of flow cytometry it provides flexible separations based on multiple parameters. Unlike competing technologies, such as gradient or magnetic separations that offer much larger total throughput, flow cytometric cell sorting permits selections based on various levels of fluorescent reporters, rather the complete presence or absence of the reporter. As such, this technology has found application in a huge range of fields. This chapter aims to describe the utility of single-cell sorting with particular emphasis given to index sorting. This is followed by two recently developed novel techniques of sorting cells or particles. The first of these is positional sorting which is useful in cell-based studies where sorting can proceed and produce meaningful results without being inherently dependant on prior knowledge of where gates should be set. Secondly, reflective plate sorting is introduced which positionally links multiwell sample and collection plates in a convenient assay format so that cells in the collection plate "reflect" those in the sample plate.

  12. Progress in the Development of Superconducting Quadrupoles forHeavy-ion Fusion

    Energy Technology Data Exchange (ETDEWEB)

    Faltens, A.; Lietzke, A.; Sabbi, G.; Seidl, P.; Lund, S.; Manahan, R.; Martovetsky, N.; Gung, C.; Minervini, J.; Schultz, J.; Myatt, L.; Meinke, R.

    2002-08-19

    The Heavy Ion Fusion program is developing single aperture superconducting quadrupoles based on NbTi conductor, for use in the High Current Experiment at Lawrence Berkeley National Laboratory. Following the fabrication and testing of prototypes using two different approaches, a baseline design has been selected and further optimized. A prototype cryostat for a quadrupole doublet, with features to accommodate induction acceleration modules, is being fabricated. The single aperture magnet was derived from a conceptual design of a quadrupole array magnet for multi-beam transport. Progress on the development of superconducting quadrupole arrays for future experiments is also reported.

  13. Progress in the development of superconducting quadrupoles for heavy ion fusion

    Energy Technology Data Exchange (ETDEWEB)

    Faltens, A.; Lietzke, A.; Sabbi, G.; Seidl, P.; Lund, S.; Manahan, B.; Martovetsky, N.; Gung, C.; Minervini, J.; Schultz, J.; Myatt, L.; Meinke, R.

    2002-05-24

    The Heavy Ion Fusion program is developing single aperture superconducting quadrupoles based on NbTi conductor, for use in the High Current Experiment at Lawrence Berkeley National Laboratory. Following the fabrication and testing of prototypes using two different approaches, a baseline design has been selected and further optimized. A prototype cryostat for a quadrupole doublet, with features to accommodate induction acceleration modules, is being fabricated. The single aperture magnet was derived from a conceptual design of a quadrupole array magnet for multi-beam transport. Progress on the development of superconducting quadrupole arrays for future experiments is also reported.

  14. Sorting a distribution theory

    CERN Document Server

    Mahmoud, Hosam M

    2011-01-01

    A cutting-edge look at the emerging distributional theory of sorting Research on distributions associated with sorting algorithms has grown dramatically over the last few decades, spawning many exact and limiting distributions of complexity measures for many sorting algorithms. Yet much of this information has been scattered in disparate and highly specialized sources throughout the literature. In Sorting: A Distribution Theory, leading authority Hosam Mahmoud compiles, consolidates, and clarifies the large volume of available research, providing a much-needed, comprehensive treatment of the

  15. Individual cell sorting.

    Science.gov (United States)

    Stovel, R T; Sweet, R G

    1979-01-01

    Current cell sorting machines do not preserve the individual identity of processed cells; after analysis, the cells are assigned to a subpopulation where they are pooled with other similar cells. This paper reports progress on a system that sorts cells individually to precise locations on a microscope slide and preserves them for further observation with a light microscope while recording flow measurement data for each cell. Various electronic and mechanical modifications to an existing sorting machine are described that increase drop placement accuracy and permit individual cell sorting.

  16. Designing sorting networks

    CERN Document Server

    Baddar, Sherenaz W Al-Haj

    2012-01-01

    Designing Sorting Networks: A New Paradigm provides an in-depth guide to maximizing the efficiency of sorting networks, and uses 0/1 cases, partially ordered sets and Haase diagrams to closely analyze their behavior in an easy, intuitive manner. This book also outlines new ideas and techniques for designing faster sorting networks using Sortnet, and illustrates how these techniques were used to design faster 12-key and 18-key sorting networks through a series of case studies. Finally, it examines and explains the mysterious behavior exhibited by the fastest-known 9-step 16-key network. Designi

  17. Sorting out Downside Beta

    NARCIS (Netherlands)

    G.T. Post (Thierry); P. van Vliet (Pim); S.D. Lansdorp (Simon)

    2009-01-01

    textabstractDownside risk, when properly defined and estimated, helps to explain the cross-section of US stock returns. Sorting stocks by a proper estimate of downside market beta leads to a substantially larger cross-sectional spread in average returns than sorting on regular market beta. This

  18. Cell sorting in development.

    Science.gov (United States)

    Krens, S F Gabby; Heisenberg, Carl-Philipp

    2011-01-01

    During the development of multicellular organisms, cell fate specification is followed by the sorting of different cell types into distinct domains from where the different tissues and organs are formed. Cell sorting involves both the segregation of a mixed population of cells with different fates and properties into distinct domains, and the active maintenance of their segregated state. Because of its biological importance and apparent resemblance to fluid segregation in physics, cell sorting was extensively studied by both biologists and physicists over the last decades. Different theories were developed that try to explain cell sorting on the basis of the physical properties of the constituent cells. However, only recently the molecular and cellular mechanisms that control the physical properties driving cell sorting, have begun to be unraveled. In this review, we will provide an overview of different cell-sorting processes in development and discuss how these processes can be explained by the different sorting theories, and how these theories in turn can be connected to the molecular and cellular mechanisms driving these processes.

  19. Toward the production of 50 000 tonnes of low-carbon steel sheet for the LHC superconducting dipole and quadrupole magnets

    CERN Document Server

    Babic, S; Beckers, F; Brixhe, F; Peiro, G; Verbeeck, T

    2002-01-01

    A total of 50 000 tonnes of low-carbon steel sheet has been ordered for the LHC main magnets. After three years of production, about 10 000 tonnes of steel sheet have been produced by Cockerill-Sambre Groupe Usinor. This paper gives a summary of the manufacturing process and improvements implemented as well as an overview of the difficulties encountered during this production. Preliminary statistics obtained for the mechanical and magnetic steel properties are presented. (6 refs).

  20. Towards the production of 50'000 tonnes of low-carbon steel sheet for the LHC superconducting dipole and quadrupole magnets

    CERN Document Server

    Babic, S; Brixhe, F; Comel, S; Peiro, G; Verbeeck, T

    2002-01-01

    A total of 50'000 tonnes of low-carbon steel sheet has been ordered for the LHC main magnets. After three years of production, about 10'000 tonnes of steel sheet have been produced by Cockerill-Sambre Groupe Usinor. This paper gives a summary of the manufacturing process and improvements implemented as well as an overview of the difficulties encountered during this production. Preliminary statistics obtained for the mechanical and magnetic steel properties are presented.

  1. Development and testing of the improved focusing quadrupole for heavy ion fusion accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Manahan, R R; Martovetsky, N N; Meinke, R B; Chiesa, L; Lietzke, A F; Sabbi, G L; Seidl, P A

    2003-10-23

    An improved version of the focusing magnet for a Heavy Ion Fusion (HIF) accelerator was designed, built and tested in 2002-2003. This quadrupole has higher focusing power and lower error field than the previous version of the focusing quadrupoles successfully built and tested in 2001. We discuss the features of the new design, selected fabrication issues and test results.

  2. Quadrupole transitions revealed by Borrmann spectroscopy.

    Science.gov (United States)

    Pettifer, Robert F; Collins, Stephen P; Laundy, David

    2008-07-10

    The Borrmann effect-a dramatic increase in transparency to X-ray beams-is observed when X-rays satisfying Bragg's law diffract through a perfect crystal. The minimization of absorption seen in the Borrmann effect has been explained by noting that the electric field of the X-ray beam approaches zero amplitude at the crystal planes, thus avoiding the atoms. Here we show experimentally that under conditions of absorption suppression, the weaker electric quadrupole absorption transitions are effectively enhanced to such a degree that they can dominate the absorption spectrum. This effect can be exploited as an atomic spectroscopy technique; we show that quadrupole transitions give rise to additional structure at the L(1), L(2) and L(3) absorption edges of gadolinium in gadolinium gallium garnet, which mark the onset of excitations from 2s, 2p(1/2) and 2p(3/2) atomic core levels, respectively. Although the Borrmann effect served to underpin the development of the theory of X-ray diffraction, this is potentially the most important experimental application of the phenomenon since its first observation seven decades ago. Identifying quadrupole features in X-ray absorption spectroscopy is central to the interpretation of 'pre-edge' spectra, which are often taken to be indicators of local symmetry, valence and atomic environment. Quadrupolar absorption isolates states of different symmetries to that of the dominant dipole spectrum, and typically reveals orbitals that dominate the electronic ground-state properties of lanthanides and 3d transition metals, including magnetism. Results from our Borrmann spectroscopy technique feed into contemporary discussions regarding resonant X-ray diffraction and the nature of pre-edge lines identified by inelastic X-ray scattering. Furthermore, because the Borrmann effect has been observed in photonic materials, it seems likely that the quadrupole enhancement reported here will play an important role in modern optics.

  3. 120-mm superconducting quadrupole for interaction regions of hadron colliders

    CERN Document Server

    Zlobin, A V; Mokhov, N V; Novitski, I

    2012-01-01

    Magnetic and mechanical designs of a Nb3Sn quadrupole magnet with 120-mm aperture suitable for interaction regions of hadron colliders are presented. The magnet is based on a two-layer shell-type coil and a cold iron yoke. Special spacers made of a low-Z material are implemented in the coil mid-planes to reduce the level of radiation heat deposition and radiation dose in the coil. The quadrupole mechanical structure is based on aluminum collars supported by an iron yoke and a stainless steel skin. Magnet parameters including maximum field gradient and field harmonics, Nb3Sn coil pre-stress and protection at the operating temperatures of 4.5 and 1.9 K are reported. The level and distribution of radiation heat deposition in the coil and other magnet components are discussed.

  4. Towards an optimized coupling-loss induced quench protection system (CLIQ) for quadrupole magnets (Proc. 25th ICEC & ICMC2014 conference)

    NARCIS (Netherlands)

    Ravaioli, Emmanuele; Datskov, Vladimir I.; Desbiolles, Vincent; Feuvrier, Jerome; Kirby, Glyn; Maciejewski, Michal; Sperin, Kevin A.; Kate, ten Herman H.J.; Verweij, Arjan P.; Willering, G.

    2015-01-01

    The recently developed Coupling-Loss-Induced Quench (CLIQ) protection system is a new method for initiating a fast and voluminous transition to the normal state for protecting high energy density superconducting magnets. Its simple and robust electrical design, its lower failure rate, and its more e

  5. Layers in sorting practices: Sorting out patients with potential cancer

    DEFF Research Database (Denmark)

    Møller, Naja Holten; Bjørn, Pernille

    2011-01-01

    mechanism, but is handled by informal sorting mechanisms. We identify two informal sorting mechanisms with large impact on the sorting practices, namely subtle categorizing and collective remembering. These informal sorting mechanisms have implications for the design of electronic booking systems because...

  6. LazySorted: A Lazily, Partially Sorted Python List

    Directory of Open Access Journals (Sweden)

    Naftali Harris

    2015-06-01

    Full Text Available LazySorted is a Python C extension implementing a partially and lazily sorted list data structure. It solves a common problem faced by programmers, in which they need just part of a sorted list, like its middle element (the median, but sort the entire list to get it. LazySorted presents them with the abstraction that they are working with a fully sorted list, while actually only sorting the list partially with quicksort partitions to return the requested sub-elements. This enables programmers to use naive "sort first" algorithms but nonetheless attain linear run-times when possible. LazySorted may serve as a drop-in replacement for the built-in sorted function in most cases, and can sometimes achieve run-times more than 7 times faster.

  7. Prototype Superconducting Quadrupole for the ISR low-beta insertion

    CERN Multimedia

    CERN PhotoLab

    1977-01-01

    The picture shows the cold mass of the Quadrupole with its outer aluminium alloy rings pre-compressing the superconducting coils via the magnetic yoke split in 4 parts.The end of the inner vacuum chamber,supporting the 6-pole correction windings, can also be seen as well as the electrical connections. See also photos 7702690X, 7702307.

  8. Status of the LHC inner triplet quadrupole program at Fermilab

    CERN Document Server

    Andreev, N; Bauer, P; Bossert, R; Brandt, J; Carson, J; Caspi, S; Chichili, D R; Chiesa, L; Darve, C; Di Marco, J; Fehér, S; Ghosh, A; Glass, H; Huang, Y; Kerby, J S; Lamm, M J; Markarov, A A; McInturff, A D; Nicol, T H; Nobrega, A; Novitski, I; Ogitsu, T; Orris, D; Ozelis, J P; Page, T; Peterson, T; Rabehl, Roger Jon; Robotham, W; Sabbi, G L; Scanlan, R M; Schlabach, P; Sylvester, C D; Strait, J B; Tartaglia, M; Tompkins, J C; Velev, G V; Yadav, S; Zlobin, A V

    2001-01-01

    Fermilab, in collaboration with LBNL and BNL, is developing a quadrupole for installation in the interaction region inner triplets of the LHC. This magnet is required to have an operating gradient of 215 T/m across a 70 mm coil bore, and operates in superfluid helium at 1.9 K. A 2 m magnet program addressing mechanical, magnetic, quench protection, and thermal issues associated with the design was completed earlier this year, and production of the first full length, cryostatted prototype magnet is underway. This paper summarizes the conclusions of the 2 m program, and the design and status of the first full-length prototype magnet. (11 refs).

  9. Sorting Plastic Waste in Hydrocyclone

    Directory of Open Access Journals (Sweden)

    Ernestas Šutinys

    2011-02-01

    Full Text Available The article presents material about sorting plastic waste in hydrocyclone. The tests on sorting plastic waste were carried out. Also, the findings received from the performed experiment on the technology of sorting plastic waste are interpreted applying an experimental model of the equipment used for sorting plastics of different density.Article in Lithuanian

  10. Ready, steady, SORT!

    CERN Multimedia

    Laëtitia Pedroso

    2010-01-01

    The selective or ecological sorting of waste is already second nature to many of us and concerns us all. As the GS Department's new awareness-raising campaign reminds us, everything we do to sort waste contributes to preserving the environment.    Placemats printed on recycled paper using vegetable-based ink will soon be distributed in Restaurant No.1.   Environmental protection is never far from the headlines, and CERN has a responsibility to ensure that the 3000 tonnes and more of waste it produces every year are correctly and selectively sorted. Materials can be given a second life through recycling and re-use, thereby avoiding pollution from landfill sites and incineration plants and saving on processing costs. The GS Department is launching a new poster campaign designed to raise awareness of the importance of waste sorting and recycling. "After conducting a survey to find out whether members of the personnel were prepared to make an effort to sort a...

  11. Flow sorting in aquatic ecology

    OpenAIRE

    Marcus Reckermann

    2000-01-01

    Flow sorting can be a very helpful tool in revealing phytoplankton and bacterial community structure and elaborating specific physiological parameters of isolated species. Droplet sorting has been the most common technique. Despite the high optical and hydro-dynamic stress for the cells to be sorted, many species grow in culture subsequent to sorting. To date, flow sorting has been applied to post-incubation separation in natural water samples to account for group-specific physiological param...

  12. Low-frequency quadrupole impedance of undulators and wigglers

    Directory of Open Access Journals (Sweden)

    A. Blednykh

    2016-10-01

    Full Text Available An analytical expression of the low-frequency quadrupole impedance for undulators and wigglers is derived and benchmarked against beam-based impedance measurements done at the 3 GeV NSLS-II storage ring. The adopted theoretical model, valid for an arbitrary number of electromagnetic layers with parallel geometry, allows to calculate the quadrupole impedance for arbitrary values of the magnetic permeability μ_{r}. In the comparison of the analytical results with the measurements for variable magnet gaps, two limit cases of the permeability have been studied: the case of perfect magnets (μ_{r}→∞, and the case in which the magnets are fully saturated (μ_{r}=1.

  13. Sorting by Recursive Partitioning,

    Science.gov (United States)

    1983-12-01

    asymptotic time-complexity. This paper has the following main parts: First, a Pidgin -Algol version of the algorithm is presented and we discuss the main...those sorted subsets e) end "UsingBin*; end "AdaptSorting. 4 "Figure 1: A condensed Pidgin -Algol version of Adaptsort eiFor some conditions that we will...algorithm which have to be completed in either linear or constant times (these required critical times appear as comments in the Pidgin -Algol version

  14. Wage Sorting Trends

    DEFF Research Database (Denmark)

    Bagger, Jesper; Vejlin, Rune Majlund; Sørensen, Kenneth Lykke

    Using a population-wide Danish Matched Employer-Employee panel from 1980-2006, we document a strong trend towards more positive assortative wage sorting. The correlation between worker and firm fixed effects estimated from a log wage regression increases from -0.07 in 1981 to .14 in 2001. The non......Using a population-wide Danish Matched Employer-Employee panel from 1980-2006, we document a strong trend towards more positive assortative wage sorting. The correlation between worker and firm fixed effects estimated from a log wage regression increases from -0.07 in 1981 to .14 in 2001...

  15. Electrostatic quadrupole focusing in the AGS g-2 storage ring

    Energy Technology Data Exchange (ETDEWEB)

    Bennett, G.; Larsen, R.; Morse, W.; Semertzidis, Y.; Yelk, J. [Brookhaven National Lab., Upton, NY (United States); Liu, Z. [Boston Univ., MA (United States). Dept. of Physics

    1993-06-01

    Electrostatic quadrupole focusing is to be used in the high precision measurement of the anomalous magnetic moment of the muon, AGS Experiment 821. The final design uses planar rather than hyperbolic electrodes, and the field is pulsed to minimize the effect of trapped electrons. The mechanical design is described. Performance in a 1.5T magnetic field at less than 10{sup {minus}6} Torr is reviewed.

  16. Electrostatic quadrupole focusing in the AGS g-2 storage ring

    Energy Technology Data Exchange (ETDEWEB)

    Bennett, G.; Larsen, R.; Morse, W.; Semertzidis, Y.; Yelk, J. (Brookhaven National Lab., Upton, NY (United States)); Liu, Z. (Boston Univ., MA (United States). Dept. of Physics)

    1993-01-01

    Electrostatic quadrupole focusing is to be used in the high precision measurement of the anomalous magnetic moment of the muon, AGS Experiment 821. The final design uses planar rather than hyperbolic electrodes, and the field is pulsed to minimize the effect of trapped electrons. The mechanical design is described. Performance in a 1.5T magnetic field at less than 10[sup [minus]6] Torr is reviewed.

  17. Design report of the QTG quadrupoles for the CERN CNGS line

    CERN Document Server

    Zickler, T

    2000-01-01

    This report presents the actual QTG design. The quadrupole magnets are part of the "CERN Neutrino to Gran Sasso" transfer line TT40. The design is optimized for a nominal beam energy of 400 GeV. The quadrupoles are resistive iron-dominated magnets with a gradient of 40 T/m and an inscribed radius of 22.5 mm. The 2200 mm long yokes will be built form low carbon steel laminations stacked between non-laminated end plates.

  18. First Test Results of the 150 mm Aperture IR Quadrupole Models for the High Luminosity LHC

    Energy Technology Data Exchange (ETDEWEB)

    Ambrosio, G. [Fermilab; Chlachidze, G. [Fermilab; Wanderer, P. [Brookhaven; Ferracin, P. [CERN; Sabbi, G. [LBNL, Berkeley

    2016-10-06

    The High Luminosity upgrade of the LHC at CERN will use large aperture (150 mm) quadrupole magnets to focus the beams at the interaction points. The high field in the coils requires Nb3Sn superconductor technology, which has been brought to maturity by the LHC Accelerator Re-search Program (LARP) over the last 10 years. The key design targets for the new IR quadrupoles were established in 2012, and fabrication of model magnets started in 2014. This paper discusses the results from the first single short coil test and from the first short quadrupole model test. Remaining challenges and plans to address them are also presented and discussed.

  19. Gender Differences in Sorting

    DEFF Research Database (Denmark)

    Merlino, Luca Paolo; Parrotta, Pierpaolo; Pozzoli, Dario

    In this paper, we investigate the sorting of workers in firms to understand gender gaps in labor market outcomes. Using Danish employer-employee matched data, we fiend strong evidence of glass ceilings in certain firms, especially after motherhood, preventing women from climbing the career ladder...

  20. Protein Sorting Prediction

    DEFF Research Database (Denmark)

    Nielsen, Henrik

    2017-01-01

    Many computational methods are available for predicting protein sorting in bacteria. When comparing them, it is important to know that they can be grouped into three fundamentally different approaches: signal-based, global-property-based and homology-based prediction. In this chapter, the strengths...

  1. Sorting and sustaining cooperation

    DEFF Research Database (Denmark)

    Vikander, Nick

    2013-01-01

    This paper looks at cooperation in teams where some people are selfish and others are conditional cooperators, and where lay-offs will occur at a fixed future date. I show that the best way to sustain cooperation prior to the lay-offs is often in a sorting equilibrium, where conditional cooperato...

  2. Det sorte USA

    DEFF Research Database (Denmark)

    Brøndal, Jørn

    Bogen gennemgår det sorte USAs historie fra 1776 til 2016, idet grundtemaet er spændingsforholdet mellem USAs grundlæggelsesidealer og den racemæssige praksis, et spændingsforhold som Gunnar Myrdal kaldte "det amerikanske dilemma." Bogen, der er opbygget som politisk, social og racemæssig historie...

  3. Online Sorted Range Reporting

    DEFF Research Database (Denmark)

    Brodal, Gerth Stølting; Fagerberg, Rolf; Greve, Mark

    2009-01-01

    We study the following one-dimensional range reporting problem: On an arrayA of n elements, support queries that given two indices i ≤ j and an integerk report the k smallest elements in the subarray A[i..j] in sorted order. We present a data structure in the RAM model supporting such queries in ...

  4. SORTING CAPABILITIES OF CASTINGS FROM NODULAR AND GRAY IRON BY THE STRUCTURE BY THE RESULT OF THE MEASUREMENT OF THE MAGNETIC PARAMETERS AND THE SPEED OF SOUND

    Directory of Open Access Journals (Sweden)

    S. G. Sandomirskiy

    2013-01-01

    Full Text Available The results of the analysis of the influence of changes in the structure of the metal substrate and form of graphite inclusions in cast iron on the magnetic coercive sensitive parameter and the speed of sound are given. The efficiency of shared use of the results of magnetic and ultrasonic measurements to control the shape of inclusions in ductile iron and pearlite content in its metal matrix is shown.

  5. Drive Beam Quadrupoles for the CLIC Project: a Novel Method of Fiducialisation and a New Micrometric Adjustment System

    CERN Document Server

    AUTHOR|(SzGeCERN)411678; Duquenne, Mathieu; Sandomierski, Jacek; Sosin, Mateusz; Rude, Vivien

    2014-01-01

    This paper presents a new method of fiducialisation applied to determine the magnetic axis of the Drive Beam quadrupole of the CLIC project with respect to external alignment fiducials, within a micrometric accuracy and precision. It introduces also a new micrometric adjustment system along 5 Degrees of Freedom, developed for the same Drive Beam quadrupole. The combination of both developments opens very interesting perspectives to get a more simple and accurate alignment of the quadrupoles.

  6. A twin aperture resistive quadrupole for the LHC

    CERN Document Server

    Clark, G S; de Rijk, G; Racine, M

    2000-01-01

    The European Organization for Nuclear Research (CERN) is constructing the Large Hadron Collider (LHC). The LHC's cleaning insertions require 48 twin aperture resistive quadrupoles. These 3.1 m long magnets have a gradient of 35 T/m for an inscribed circle of 46 mm diameter and an aperture separation distance of 224 mm. This magnet project is part of the Canadian contribution to the LHC. A prototype magnet was delivered in May 1998 and measured at CERN. Design changes were made based on the results. Due to the small apertures and the complicated geometry, the mechanical precision of the laminations and stacks is the main issue in the production of these quadrupoles. Series production will start in October 1999. The design and the measurement results are described in this paper. (1 refs).

  7. K-sort: A new sorting algorithm that beats Heap sort for n <= 70 lakhs!

    CERN Document Server

    Sundararajan, Kiran Kumar; Chakraborty, Soubhik; Mahanti, N C

    2011-01-01

    Sundararajan and Chakraborty (2007) introduced a new version of Quick sort removing the interchanges. Khreisat (2007) found this algorithm to be competing well with some other versions of Quick sort. However, it uses an auxiliary array thereby increasing the space complexity. Here, we provide a second version of our new sort where we have removed the auxiliary array. This second improved version of the algorithm, which we call K-sort, is found to sort elements faster than Heap sort for an appreciably large array size (n <= 70,00,000) for uniform U[0, 1] inputs.

  8. Chip-based droplet sorting

    Energy Technology Data Exchange (ETDEWEB)

    Beer, Neil Reginald; Lee, Abraham; Hatch, Andrew

    2014-07-01

    A non-contact system for sorting monodisperse water-in-oil emulsion droplets in a microfluidic device based on the droplet's contents and their interaction with an applied electromagnetic field or by identification and sorting.

  9. Chip-based droplet sorting

    Science.gov (United States)

    Beer, Neil Reginald; Lee, Abraham; Hatch, Andrew

    2014-07-01

    A non-contact system for sorting monodisperse water-in-oil emulsion droplets in a microfluidic device based on the droplet's contents and their interaction with an applied electromagnetic field or by identification and sorting.

  10. Heideggers sorte arv

    DEFF Research Database (Denmark)

    Olesen, Søren Gosvig

    2015-01-01

    Martin Heidegger var antisemit, men er hans tænkning og intellektuelle arv det også? Søren Gosvig Olesen opsøger den store tyske tænkers arvinger og bindene fra 1938-48 i Heideggers efterladte ’Sorte hæfter’, hvor den lille mands meninger blander sig med en stor tænkers tanker......Martin Heidegger var antisemit, men er hans tænkning og intellektuelle arv det også? Søren Gosvig Olesen opsøger den store tyske tænkers arvinger og bindene fra 1938-48 i Heideggers efterladte ’Sorte hæfter’, hvor den lille mands meninger blander sig med en stor tænkers tanker...

  11. Sorting quantum systems efficiently

    Science.gov (United States)

    Ionicioiu, Radu

    2016-05-01

    Measuring the state of a quantum system is a fundamental process in quantum mechanics and plays an essential role in quantum information and quantum technologies. One method to measure a quantum observable is to sort the system in different spatial modes according to the measured value, followed by single-particle detectors on each mode. Examples of quantum sorters are polarizing beam-splitters (PBS) – which direct photons according to their polarization – and Stern-Gerlach devices. Here we propose a general scheme to sort a quantum system according to the value of any d-dimensional degree of freedom, such as spin, orbital angular momentum (OAM), wavelength etc. Our scheme is universal, works at the single-particle level and has a theoretical efficiency of 100%. As an application we design an efficient OAM sorter consisting of a single multi-path interferometer which is suitable for a photonic chip implementation.

  12. Nuclear Quadrupole Moments and Nuclear Shell Structure

    Science.gov (United States)

    Townes, C. H.; Foley, H. M.; Low, W.

    1950-06-23

    Describes a simple model, based on nuclear shell considerations, which leads to the proper behavior of known nuclear quadrupole moments, although predictions of the magnitudes of some quadrupole moments are seriously in error.

  13. Accretion disks around a mass with quadrupole

    CERN Document Server

    Abishev, Medeu; Quevedo, Hernando; Toktarbay, Saken

    2015-01-01

    We consider the stability properties of test particles moving along circular orbits around a mass with quadrupole. We show that the quadrupole modifies drastically the properties of an accretion disk made of such test particles.

  14. Accretion disks around a mass with quadrupole

    Science.gov (United States)

    Abishev, M.; Boshkayev, K.; Quevedo, H.; Toktarbay, S.

    We consider the stability properties of circular orbits of test particles moving around a mass with quadrupole. We show that the quadrupole modifies drastically the properties of an accretion disk made of such test particles.

  15. Fiducialization of the small-aperture quadrupoles based on the vibrating wire method

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Baichuan, E-mail: wangbaichuan@nint.ac.cn [State Key Laboratory of Intense Pulsed Radiation Simulation and Effect (Northwest Institute of Nuclear Technology), Xi' an 710024 (China); Tsinghua University, Beijing 100084 (China); Zheng, Shuxin, E-mail: zhengsx@tsinghua.edu.cn [Tsinghua University, Beijing 100084 (China); Wu, Lin; Du, Changtong; Xing, Qingzi [Tsinghua University, Beijing 100084 (China); Wang, Zhongming; Qiu, Mengtong [State Key Laboratory of Intense Pulsed Radiation Simulation and Effect (Northwest Institute of Nuclear Technology), Xi' an 710024 (China); Wang, Xuewu [Tsinghua University, Beijing 100084 (China)

    2016-03-11

    A fiducialization method based on vibrating wire is described dedicated to the problem of locating the magnetic center relative to external fiducials for the small-aperture quadrupoles. The advantage of this method is that the measurement of the wire position, which may be the main error source, is no longer needed. The position of the magnetic center can be directly obtained by measuring the position shift of the magnet fiducials. This method has been validated on small Permanent Magnet Quadrupoles (PMQs). Experiments have confirmed its feasibility of measuring PMQs with good repeatability of about 10 μm, and shown its high sensitivity as well as convenience.

  16. Magnetic activated cell sorting and its application in the studies of male infertility%磁性活性细胞分选技术在男性不育研究中的应用

    Institute of Scientific and Technical Information of China (English)

    邓雪连

    2012-01-01

    Magnetic activated cell sorting ( MACS) is considered as a flexible, fast, specific and simple cell sorting system that can separate target cells effectively according to specific markers on the cell surface, for which it has won a wide clinical application. MACS offers a new platform for male infertility research, as well as a novel idea for applying this technology in the optimization of semen quality and the isolation of germ cells. This article briefly introduces the basic principles of MACS, and summaries its present and potential clinical application in male infertility research, as in spermatozoa selection and cryopreservation, and the isolation of spermat-ogonial stem cells and germ cells.%磁性活性细胞分选法(MACS)根据细胞表面特异的标记物,在分子水平对目的细胞进行有效分选,具有简易、快速、灵活、特异性高的特点,在临床方面有着广泛的应用.MACS也为男性不育提供了一个新的研究平台,将MACS用于精液质量优化与生殖细胞分离是男性不育研究的一个新思路.本文简要介绍了MACS的基本原理,综述了MACS在精子优选、冷冻保存、精原干细胞及生精细胞分离等男性不育研究方面的应用现状和临床应用前景.

  17. Small Aperture BPM to Quadrupole Assembly Tolerance Study

    Energy Technology Data Exchange (ETDEWEB)

    Fong, K. W.

    2010-12-07

    The LCLS injector and linac systems utilize a series of quadrupole magnets with a beam position monitor (BPM) captured in the magnet pole tips. The BPM measures the electron beam position by comparing the electrical signal from 4 electrodes and interpolating beam position from these signals. The manufacturing tolerances of the magnet and BPM are critical in determining the mechanical precision of the electrodes relative to the nominal electron beam Z-axis. This study evaluates the statistical uncertainty of the electrodes center axis relative to the nominal electron beam axis.

  18. Superconducting focusing quadrupoles for heavy ion fusion experiments

    Energy Technology Data Exchange (ETDEWEB)

    Sabbi, G.L.; Faltens, A.; Leitner, M.; Lietzke, A.; Seidl, P.; Barnard, J.; Lund, S.; Martovetsky, N.; Gung, C.; Minervini, J.; Radovinsky, A.; Schultz, J.; Meinke, R.

    2003-05-01

    The Heavy Ion Fusion (HIF) Program is developing superconducting focusing magnets for both near-term experiments and future driver accelerators. In particular, single bore quadrupoles have been fabricated and tested for use in the High Current Experiment (HCX) at Lawrence Berkeley National Laboratory (LBNL). The next steps involve the development of magnets for the planned Integrated Beam Experiment (IBX) and the fabrication of the first prototype multi-beam focusing arrays for fusion driver accelerators. The status of the magnet R&D program is reported, including experimental requirements, design issues and test results.

  19. Atomic Quadrupole Moment Measurement Using Dynamic Decoupling.

    Science.gov (United States)

    Shaniv, R; Akerman, N; Ozeri, R

    2016-04-01

    We present a method that uses dynamic decoupling of a multilevel quantum probe to distinguish small frequency shifts that depend on m_{j}^{2}, where m_{j}^{2} is the angular momentum of level |j⟩ along the quantization axis, from large noisy shifts that are linear in m_{j}, such as those due to magnetic field noise. Using this method we measured the electric-quadrupole moment of the 4D_{5/2} level in ^{88}Sr^{+} to be 2.973_{-0.033}^{+0.026}ea_{0}^{2}. Our measurement improves the uncertainty of this value by an order of magnitude and thus helps mitigate an important systematic uncertainty in ^{88}Sr^{+} based optical atomic clocks and verifies complicated many-body quantum calculations.

  20. High Gradient $Nb_3Sn$ Quadrupole Demonstrator MKQXF Engineering Design

    CERN Document Server

    Kokkinos, C; Karppinen, Mikko; CERN. Geneva. ATS Department

    2016-01-01

    A new mechanical design concept for the $Nb_3Sn$ quadrupoles has been developed with a goal of an accelerator quality magnet that can be industrially produced in large series. This concept can easily be extended to any length and applied on both 1-in-1 and 2-in-1 configurations. It is based on the pole-loading concept and collared coils using dipole-type collars. Detailed design optimisation of a demonstrator magnet based on present base-line HL-LHC IR quadrupole QXF coil geometry has been carried out including the end regions. This report describes the design concept and the fully parametric multi-physics finite element (FE) models that were used to determine the optimal assembly parameters including the effects of the manufacturing tolerances.

  1. Spin-the-bottle Sort and Annealing Sort: Oblivious Sorting via Round-robin Random Comparisons

    CERN Document Server

    Goodrich, Michael T

    2010-01-01

    We study sorting algorithms based on randomized round-robin comparisons. Specifically, we study Spin-the-bottle sort, where comparisons are unrestricted, and Annealing sort, where comparisons are restricted to a distance bounded by a \\emph{temperature} parameter. Both algorithms are simple, randomized, data-oblivious sorting algorithms, which are useful in privacy-preserving computations, but, as we show, Annealing sort is much more efficient. We show that there is an input permutation that causes Spin-the-bottle sort to require $\\Omega(n^2\\log n)$ expected time in order to succeed, and that in $O(n^2\\log n)$ time this algorithm succeeds with high probability for any input. We also show there is an implementation of Annealing sort that runs in $O(n\\log n)$ time and succeeds with very high probability.

  2. Spin-the-bottle Sort and Annealing Sort: Oblivious Sorting via Round-robin Random Comparisons.

    Science.gov (United States)

    Goodrich, Michael T

    2014-03-01

    We study sorting algorithms based on randomized round-robin comparisons. Specifically, we study Spin-the-bottle sort, where comparisons are unrestricted, and Annealing sort, where comparisons are restricted to a distance bounded by a temperature parameter. Both algorithms are simple, randomized, data-oblivious sorting algorithms, which are useful in privacy-preserving computations, but, as we show, Annealing sort is much more efficient. We show that there is an input permutation that causes Spin-the-bottle sort to require Ω(n(2) log n) expected time in order to succeed, and that in O(n(2) log n) time this algorithm succeeds with high probability for any input. We also show there is a specification of Annealing sort that runs in O(n log n) time and succeeds with very high probability.

  3. Deductive sort and climbing sort: new methods for non-dominated sorting.

    Science.gov (United States)

    McClymont, Kent; Keedwell, Ed

    2012-01-01

    In recent years an increasing number of real-world many-dimensional optimisation problems have been identified across the spectrum of research fields. Many popular evolutionary algorithms use non-dominance as a measure for selecting solutions for future generations. The process of sorting populations into non-dominated fronts is usually the controlling order of computational complexity and can be expensive for large populations or for a high number of objectives. This paper presents two novel methods for non-dominated sorting: deductive sort and climbing sort. The two new methods are compared to the fast non-dominated sort of NSGA-II and the non-dominated rank sort of the omni-optimizer. The results demonstrate the improved efficiencies of the deductive sort and the reductions in comparisons that can be made when applying inferred dominance relationships defined in this paper.

  4. Selective sorting of waste

    CERN Multimedia

    2007-01-01

    Not much effort needed, just willpower In order to keep the cost of disposing of waste materials as low as possible, CERN provides two types of recipient at the entrance to each building: a green plastic one for paper/cardboard and a metal one for general refuse. For some time now we have noticed, to our great regret, a growing negligence as far as selective sorting is concerned, with, for example, the green recipients being filled with a mixture of cardboard boxes full of polystyrene or protective wrappers, plastic bottles, empty yogurts pots, etc. …We have been able to ascertain, after careful checking, that this haphazard mixing of waste cannot be attributed to the cleaning staff but rather to members of the personnel who unscrupulously throw away their rubbish in a completely random manner. Non-sorted waste entails heavy costs for CERN. For information, once a non-compliant item is found in a green recipient, the entire contents are sent off for incineration rather than recycling… We are all concerned...

  5. Short quadrupole, first at the SC, then at LEAR

    CERN Multimedia

    1982-01-01

    Quadrupoles of this type were built for the beam lines of the 600 MeV Synchro-Cylclotron. Surplus ones were installed in the LEAR injection line. The particularity of these quads is that they are very short and that a special design, resembling the "Lambertson magnet", limits and linearizes their stray field. This was achieved by the iron between the poles extending beyond the poles.

  6. Analysis of lamination measurements for CERN's twin aperture quadrupoles

    CERN Document Server

    Clark, G S

    2002-01-01

    The European Organization for Nuclear Research (CERN) is constructing the Large Hadron Collider (LHC). The LHC's cleaning insertions require 48 twin aperture resistive quadrupoles. The laminations for these magnets are punched from low carbon steel sheet 1.5 mm thick. To check the quality of the laminations, samples are regularly collected and measured. This paper describes how these measurements are analyzed. This work is part of the Canadian contribution to the LHC. (5 refs).

  7. Quadrupole Focusing Lenses for Charged Particles

    Energy Technology Data Exchange (ETDEWEB)

    Cork, Bruce; Zajec, Emery

    1953-04-15

    A set of four strong focusing magnetic quadrupole lenses has been constructed and operated. Each lens consists of four air cooled electromagnets with pole tips having a hyperbolic cross section. Each lens is 4 in. long and has an aperture 2 in. in diameter. Measurements of the magnetic field demonstrate that the hyperbolic cross section satisfies the requirements of a constant magnetic field gradient very well. The technique of deflecting a current carrying flexible wire has been used to measure the trajectory of charged particles through the system of lenses. It has been observed that the strong focusing requirements are satisfied. The system of lenses was then used to focus 0.5 Mev protons, 20 Mev deuterons, and 40 Mev alpha particles. The parallel beam of 0.5 Mev protons was detected by observing the incandescence of a quartz plate while the protons were bombarding it. The focused beam was less than 1 mm in diameter. The astigmatic 20 Mev deuteron beam from the 60 in. cyclotron was increased in current density by a factor greater than 30.

  8. Measurement of an atomic quadrupole moment using dynamic decoupling

    Science.gov (United States)

    Akerman, Nitzan; Shaniv, Ravid; Ozeri, Roee

    2016-05-01

    Some of the best clocks today are ion-based optical clocks. These clocks are referenced to a narrow optical transition in a trapped ion. An example for such a narrow transition is the electric quadrupole E 2 transition between states with identical parity. An important systematic shift of such a transition is the quadrupole shift resulting from the electric field gradient inherent to the ion trap. We present a new dynamic decoupling method that rejects magnetic field noise while measuring the small quadrupole shift of the optical clock transition. Using our sequence we measured the quadrupole moment of the 4D5/2 level in a trapped 88 Sr+ ion to be 2 .973-0 . 033 + 0 . 026 ea02 , where e is the electron charge and a0 is the Bohr radius. Our measurement improves the uncertainty of this value by an order of magnitude and thus helps mitigate an important systematic uncertainty in 88 Sr+ based optical atomic clocks and verifies complicated many-body quantum calculations.

  9. LHC interaction region quadrupole cryostat design and fabrication

    CERN Document Server

    Nicol, T H; Huang, Y; Page, Thomas M

    2002-01-01

    The cryostat of a Large Hadron Collider (LHC) Interaction Region (IR) quadrupole magnet consists of all components of the inner triplet except the magnet assembly itself. It serves to support the magnet accurately and reliably within the vacuum vessel, to house all required cryogenic piping, and to insulate the cold mass from heat radiated and conducted from the environment. It must function reliably during storage, shipping and handling, normal magnet operation, quenches, and seismic excitations, and must be able to be manufactured at low cost. The major components of the cryostat are the vacuum vessel, thermal shield, multilayer insulation system, cryogenic piping, and suspension system. The overall design of a cryostat for superconducting accelerator magnets requires consideration of fluid flow, proper selection of materials for their thermal and structural performance at both ambient and operating temperature, and knowledge of the environment to which the magnets will be subjected over the course of their...

  10. Focusing Strength Measurements of the Main Quadrupoles for the LHC

    CERN Document Server

    Smirnov, N; Calvi, M; Deferne, G; Di Marco, J; Sammut, N; Sanfilippo, S

    2006-01-01

    More than 1100 quadrupole magnets of different types are needed for the Large Hadron Collider (LHC) which is in the construction stage at CERN. The most challenging parameter to measure on these quadrupoles is the integrated gradient (Gdl). An absolute accuracy of 0.1% is needed to control the beta beating. In this paper we briefly describe the whole set of equipment used for Gdl measurements: Automated Scanner system, Single Stretched Wire system and Twin Coils system, concentrating mostly on their absolute accuracies. Most of the possible inherent effects that can introduce systematic errors are discussed along with their preventive methods. In the frame of this qualification some of the magnets were tested with two systems. The results of the intersystem cross-calibrations are presented. In addition, the qualification of the measurement system used at the magnet manufacturer's is based on results of more than 40 quadrupole assemblies tested in cold conditions at CERN and in warm conditions at the vendor si...

  11. Purification of microglia by two-step magnetic activated cell sorting%免疫磁珠分选两步法纯化原代小胶质细胞

    Institute of Scientific and Technical Information of China (English)

    孙珊珊; 王蓓蓓; 鞠莉莉; 曾辉; 徐群渊

    2012-01-01

    目的 神经系统感染研究需获得纯度高、细胞生物学状态接近体内的小胶质细胞.既往分离纯化方法 不能满足研究需要,需建立新的高效纯化方法.方法 获得小鼠全脑单细胞悬液后,应用磁珠分选阳选法,经过两步分选获得小胶质细胞.用流式细胞仪检测小胶质细胞的纯度,瑞氏-姬姆萨染色观察细胞形态,采用7-AAD染色鉴定分选后细胞的活性.结果 应用免疫磁珠分选一步法可以获得纯度达(59.98 ± 13.61)%的小胶质细胞;两步法进一步将细胞纯度提高至(97.62 ± 1.35)%.该方法 所获得的小胶质细胞活性良好,形态正常.结论 免疫磁珠分选两步法能够稳定地获得高纯度的小胶质细胞,对小胶质细胞的活性和形态无显著影响,可用于后续中枢神经系统急性感染的体外研究.%Objective The study on nervous system infection requires us to obtain microglia with high purity and biological status. However, present methods for microglia purification can not meet these requirements. It is necessary to establish an efficient separation method. Methods After having prepared the whole mouse brain cell suspension, two-step magnetic activated cell positive sorting ( MACS ) technique was applied specifically for CDllb+ microglia sorting. The purity of the cells was detected by flow cytometry, the morphology of the cells was observed by Wright-Giemsa staining, and the viability of the cells were determined by 7-AAD staining. Results The study obtained mice microglia with purity of ( 59. 98 ± 13.61 )% for Step 1 MACS and ( 97. 62 ± 1. 35 )% for Step 2 MACS, which could bear good viability and morphology. Conclusions The two-step magnetic cell sorting technique could obtain high purity microglia stably, with no significant effect on its activity and morphology. The method suits for studying the infection in CNS.

  12. Performance of the first short model 150 mm aperture Nb$_3$Sn Quadrupole MQXFS for the High- Luminosity LHC upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Chlachidze, G.; et al.

    2016-08-30

    The US LHC Accelerator Research Program (LARP) and CERN combined their efforts in developing Nb3Sn magnets for the High-Luminosity LHC upgrade. The ultimate goal of this collaboration is to fabricate large aperture Nb3Sn quadrupoles for the LHC interaction regions (IR). These magnets will replace the present 70 mm aperture NbTi quadrupole triplets for expected increase of the LHC peak luminosity by a factor of 5. Over the past decade LARP successfully fabricated and tested short and long models of 90 mm and 120 mm aperture Nb3Sn quadrupoles. Recently the first short model of 150 mm diameter quadrupole MQXFS was built with coils fabricated both by the LARP and CERN. The magnet performance was tested at Fermilab’s vertical magnet test facility. This paper reports the test results, including the quench training at 1.9 K, ramp rate and temperature dependence studies.

  13. Performance of a Nb(3)Sn Quadrupole Under High Stress

    CERN Document Server

    Felice, H; Ferracin, P; De Rijk, G; Bajko, M; Caspi, S; Bingham, B; Giloux, C; Bordini, B; Milanese, A; Bottura, L; Sabbi, G L; Hafalia, R; Godeke, A; Dietderich, D

    2011-01-01

    Future upgrades of the Large Hadron Collider (LHC) will require large aperture and high gradient quadrupoles. Nb(3)Sn is the most viable option for this application but is also known for its strain sensitivity. In high field magnets, with magnetic fields above 12 T, the Lorentz forces will generate mechanical stresses that may exceed 200 MPa in the windings. The existing measurements of critical current versus strain of Nb(3)Sn strands or cables are not easily applicable to magnets. In order to investigate the impact of high mechanical stress on the quench performance, a series of tests was carried out within a LBNL/CERN collaboration using the magnet TQS03 (a LHC Accelerator Research Program (LARP) 1-meter long, 90-mm aperture Nb(3)Sn quadrupole). The magnet was tested four times at CERN under various pre-stress conditions. The average mechanical compressive azimuthal pre-stress on the coil at 4.2 K ranged from 120 MPa to 200 MPa. This paper reports on the magnet performance during the four tests focusing on...

  14. Microtechnology for cell manipulation and sorting

    CERN Document Server

    Tseng, Peter; Carlo, Dino

    2017-01-01

    This book delves into the recent developments in the microscale and microfluidic technologies that allow manipulation at the single and cell aggregate level. Expert authors review the dominant mechanisms that manipulate and sort biological structures, making this a state-of-the-art overview of conventional cell sorting techniques, the principles of microfluidics, and of microfluidic devices. All chapters highlight the benefits and drawbacks of each technique they discuss, which include magnetic, electrical, optical, acoustic, gravity/sedimentation, inertial, deformability, and aqueous two-phase systems as the dominant mechanisms utilized by microfluidic devices to handle biological samples. Each chapter explains the physics of the mechanism at work, and reviews common geometries and devices to help readers decide the type of style of device required for various applications. This book is appropriate for graduate-level biomedical engineering and analytical chemistry students, as well as engineers and scientist...

  15. Correlation of experimental data and three-dimensional finite element modeling of a spinning quadrupole

    Science.gov (United States)

    Lorimer, W. L.; Lieu, D. K.; Hull, J. R.; Mulcahy, T. M.; Rossing, T. D.

    A permanent magnet quadrupole spinning over an aluminum disk was constructed, and drag torque was measured for various speeds and gap sizes. The experiment was modeled using a three-dimensional finite element program. Experimental and analytical results were compared, and the effect of magnet polarity was determined.

  16. Magnetic-Activated Cell Sorting of TCR-engineered T cells using tCD34 as a gene marker, but not peptide-MHC multimers, results in significant numbers of functional CD4 and CD8 T cells

    NARCIS (Netherlands)

    Govers, C.; Berrevoets, C.; Treffers-Westerlaken, E.; Broertjes, M.; Debets, R.

    2012-01-01

    T cell sorting technologies with peptide-MHC multimers or antibodies against gene markers enable enrichment of antigen-specific T cells and are expected to enhance therapeutic efficacy of clinical T cell therapy. However, a direct comparison between sorting reagents for their ability to enrich T cel

  17. Magnetic-activated cell sorting of TCR-engineered T cells, using tCD34 as a gene marker, but not peptide-MHC multimers, results in significant numbers of functional CD4+ and CD8+ T cells

    NARCIS (Netherlands)

    C.C.F.M. Govers (Coen); C.A. Berrevoets (Cor); E. Treffers-Westerlaken (Elike); M. Broertjes (Marieke); J.E.M.A. Debets (Reno)

    2012-01-01

    textabstractT cell-sorting technologies with peptide-MHC multimers or antibodies against gene markers enable enrichment of antigen-specific T cells and are expected to enhance the therapeutic efficacy of clinical T cell therapy. However, a direct comparison between sorting reagents for their ability

  18. Resolving sorting mechanisms into exosomes

    NARCIS (Netherlands)

    Stoorvogel, Willem

    2015-01-01

    The complexity of mechanisms driving protein sorting into exosomes is only beginning to emerge. In a paper recently published in Cell Research, Roucourt et al. report that trimming of heparan sulfate side chains of syndecans by endosomal heparanase facilitates sorting into exosomes by the formation

  19. Nuclear spin squeezing via electric quadrupole interaction

    Science.gov (United States)

    Aksu Korkmaz, Yaǧmur; Bulutay, Ceyhun

    2016-01-01

    Control over nuclear-spin fluctuations is essential for processes that rely on preserving the quantum state of an embedded system. For this purpose, squeezing is a viable alternative, so far that has not been properly exploited for the nuclear spins. Of particular relevance in solids is the electric quadrupole interaction (QI), which operates on nuclei having spin higher than 1/2. In its general form, QI involves an electric-field gradient (EFG) biaxiality term. Here, we show that as this EFG biaxiality increases, it enables continuous tuning of single-particle squeezing from the one-axis twisting to the two-axis countertwisting limits. A detailed analysis of QI squeezing is provided, exhibiting the intricate consequences of EFG biaxiality. The initial states over the Bloch sphere are mapped out to identify those favorable for fast initial squeezing, or for prolonged squeezings. Furthermore, the evolution of squeezing in the presence of a phase-damping channel and an external magnetic field are investigated. We observe that dephasing drives toward an antisqueezed terminal state, the degree of which increases with the spin angular momentum. Finally, QI squeezing in the limiting case of a two-dimensional EFG with a perpendicular magnetic field is discussed, which is of importance for two-dimensional materials, and the associated beat patterns in squeezing are revealed.

  20. In-situ Vibration Measurements of the CTF2 Quadrupoles

    CERN Document Server

    Coosemans, Williame

    2004-01-01

    The Compact LInear Collider (CLIC), presently under study at the European Organization for Nuclear Research (CERN), aims at colliding high energy â€ワnanobeams” at a luminosity of 1035 cm-2s-1. Vibrations of the lattice elements, if not properly corrected, can result in a loss in performance by creating both unacceptable emittance growth in the linear accelerator and relative beam-beam offsets at the interaction point. Of particular concern are the vibrations induced by the accelerator environment. For example, the circulating water used to cool the lattice quadrupoles will increase magnet vibration levels. In the framework of the CLIC stability study, in-situ measurements of quadrupole vibrations have been performed at the CLIC Test Facility 2 (CTF2) with all accelerator equipment switched on. Since the CTF2 quadrupoles and their alignment support structures are realistic prototypes of those to be used in the CLIC linac, the measurements provide a realistic estimate of the CLIC magnet vibrations in a...

  1. Busbar studies for the LHC interaction region quadrupoles

    CERN Document Server

    Bauer, P; Fehér, S; Kerby, J S; Lamm, M J; Orris, D; Sylvester, C D; Tompkins, J C; Zlobin, A V

    2001-01-01

    Fermilab (FNAL) and the Japanese high energy physics lab (KEK) are developing the superconducting quadrupole magnets for the interaction regions (IR) of the Large Hadron Collider (LHC). These magnets have a nominal field gradient of 215 T/m in a 70 mm bore and operate in superfluid helium at 1.9 K. The IR magnets are electrically interconnected with superconducting busbars, which need to be protected in the event of a quench. Experiments to determine the most suitable busbar design for the LHC IR magnets and the analysis of the data are presented. The main purpose of the study was to find a design that allows the inclusion of the superconducting busbars in the magnet quench protection scheme, thus avoiding additional quench protection circuitry. A proposed busbar design that was tested in these experiments consists of a superconducting cable, which is normally used for the inner layer of the Fermilab IR quadrupoles, soldered to similar Rutherford type cables as a stabilizer. A series of prototypes with varyin...

  2. Beta Function Measurement in the Tevatron Using Quadrupole Gradient Modulation

    CERN Document Server

    Jansson, Andreas; Volk, James T

    2005-01-01

    Early in Run2, there was an effort to compare the different emittance measurements in the Tevatron (flying wires and synchtotron light) and understand the origin of the observed differences. To measure the beta function at a few key locations near the instruments, air-core quadrupoles were installed. By modulating the gradient of these magents and measuring the effect on the tune, the lattice parameters can be extracted. Initially, the results seem to disagree with with other methods. At the time, the lattice was strongly coupled due to a skew component in the main dipoles, caused by sagging of the cryostat. After a large fraction of the superconducting magnets were shimmed to remove a strong skew quadrupole component, the results now agree with expectations, confirming that the beta function is not the major error source of discrepancy in the emittance measurement.

  3. Prototype of Superconducting Quadrupole for ISR Low-Beta Insertion

    CERN Multimedia

    1977-01-01

    In colliders, smaller beam cross-section means higher luminosity. Beam-size being proportional to the square-root of the "beta function" value, a small beta means small beam size, hence high luminosity. The first p-p collision in the ISR occurred in January 1971 and in 1973 a study was launched on low-beta insertions, which focus beams to even smaller sizes at the beam crossing points. In 1976 the first prototype of a superconducting quadrupole was tested. Here we see Theodor Tortschanoff with a prototype of 1.25 m magnetic length. Manufacture of 8 quadrupoles (4 of L=1.15 m, 4 of L=0.65 m) began at Alsthom in 1978. They were installed at point 8 of the ISR, enhancing luminosity there until final low-beta operation in December 1983. For details see "Yellow Report" CERN 76-16.

  4. Nuclear electric quadrupole moment of 9Li using zero-field β-detected NQR

    Science.gov (United States)

    Voss, A.; Pearson, M. R.; Billowes, J.; Buchinger, F.; Chow, K. H.; Crawford, J. E.; Hossein, M. D.; Kiefl, R. F.; Levy, C. D. P.; MacFarlane, W. A.; Mané, E.; Morris, G. D.; Parolin, T. J.; Saadaoui, H.; Salman, Z.; Smadella, M.; Song, Q.; Wang, D.

    2011-07-01

    A β-detected nuclear quadrupole resonance (NQR) spectrometer becomes a powerful tool to study changes in nuclear ground-state properties along isotopic chains when coupled to a laser excitation beamline to polarize the nuclei of interest. Recently, the β-NQR technique in a zero magnetic field has been applied for the first time to measure the ratio of static nuclear quadrupole moments of 8, 9Li, Q9/Q8 = 0.966 75(9) denoted by Q8 for 8Li and Q9 for 9Li, respectively. This shows agreement with present literature values but with significantly improved precision. Based on the literature, the quadrupole moment for 8Li has been re-evaluated to be |Q8| = 32.6(5) mb. From this, the quadrupole moment for 9Li is calculated as |Q9| = 31.5(5) mb with the error being dominated by the error of Q8.

  5. Microfluidic droplet sorting using integrated bilayer micro-valves

    Science.gov (United States)

    Chen, Yuncong; Tian, Yang; Xu, Zhen; Wang, Xinran; Yu, Sicong; Dong, Liang

    2016-10-01

    This paper reports on a microfluidic device capable of sorting microfluidic droplets utilizing conventional bilayer pneumatic micro-valves as sorting controllers. The device consists of two micro-valves placed symmetrically on two sides of a sorting area, each on top of a branching channel at an inclined angle with respect to the main channel. Changes in transmitted light intensity, induced by varying light absorbance by each droplet, are used to divert the droplet from the sorting area into one of the three outlet channels. When no valve is activated, the droplet flows into the outlet channel in the direction of the main channel. When one of the valves is triggered, the flexible membrane of valve will first be deflected. Once the droplet leaves the detection point, the deflected membrane will immediately return to its default flattened position, thereby exerting a drawing pressure on the droplet and deviating it from its original streamline to the outlet on the same side as the valve. This sorting method will be particularly suitable for numerous large-scale integrated microfluidic systems, where pneumatic micro-valves are already used. Only few structural modifications are needed to achieve droplet sorting capabilities in these systems. Due to the mechanical nature of diverting energy applied to droplets, the proposed sorting method may induce only minimal interference to biological species or microorganisms encapsulated inside the droplets that may accompany electrical, optical and magnetic-based techniques.

  6. Flow sorting in aquatic ecology

    Directory of Open Access Journals (Sweden)

    Marcus Reckermann

    2000-06-01

    Full Text Available Flow sorting can be a very helpful tool in revealing phytoplankton and bacterial community structure and elaborating specific physiological parameters of isolated species. Droplet sorting has been the most common technique. Despite the high optical and hydro-dynamic stress for the cells to be sorted, many species grow in culture subsequent to sorting. To date, flow sorting has been applied to post-incubation separation in natural water samples to account for group-specific physiological parameters (radiotracer-uptake rates, to the production of clonal or non-clonal cultures from mixtures, to the isolaton of cell groups from natural assemblages for molecular analyses, and for taxonomic identification of sorted cells by microscopy. The application of cell sorting from natural water samples from the Wadden Sea, including different cryptophytes, cyanobacteria and diatoms, is shown, as well as the establishment of laboratory cultures from field samples. The optional use of a red laser to account for phycocyanine-rich cells is also discussed.

  7. Tests of a 70 mm aperture quadrupole for the LHC low-$\\beta$ insertions

    CERN Document Server

    Lamm, M J; Ostojic, R; Rival, F; Rodríguez-Mateos, F; Siemko, A; Taylor, T M; Walckiers, L; Milward, S R; Treadgold, J R

    1999-01-01

    Three 70 mm aperture 1-meter superconducting quadrupole magnets for the LHC low- beta insertions have been designed and built in collaboration between CERN and Oxford Instruments. These magnets feature a four layer coil wound fromtwo 8.2 mm wide graded NbTi cables. In this paper, the authors present the results from the tests at 4.4 K and 1.9 K of the third quadrupole (Q3), with an emphasis on studies concerning quench protection. After a summary of Q3 training in three thermal cycles, quench velocities, peak temperatures in the two superconducting cables and the performance of the layer strip heaters are reported. (6 refs).

  8. An effect of nuclear electric quadrupole moments in thermonuclear fusion plasmas

    Science.gov (United States)

    De, B. R.; Srnka, L. J.

    1978-01-01

    Consideration of the nuclear electric quadrupole terms in the expression for the fusion Coulomb barrier suggests that this electrostatic barrier may be substantially modified from that calculated under the usual plasma assumption that the nuclei are electric monopoles. This effect is a result of the nonspherical potential shape and the spatial quantization of the nuclear spins of the fully stripped ions in the presence of a magnetic field. For monopole-quadrupole fuel cycles like p-B-11, the fusion cross-section may be substantially increased at low energies if the protons are injected at a small angle relative to the confining magnetic field.

  9. The radio-frequency quadrupole

    CERN Document Server

    Vretenar, Maurizio

    2013-01-01

    Radio-frequency quadrupole (RFQ) linear accelerators appeared on the accelerator scene in the late 1970s and have since revolutionized the domain of low-energy proton and ion acceleration. The RFQ makes the reliable production of unprecedented ion beam intensities possible within a compact radio-frequency (RF) resonator which concentrates the three main functions of the low-energy linac section: focusing, bunching and accelerating. Its sophisticated electrode structure and strict beam dynamics and RF requirements, however, impose severe constraints on the mechanical and RF layout, making the construction of RFQs particularly challenging. This lecture will introduce the main beam optics, RF and mechanical features of a RFQ emphasizing how these three aspects are interrelated and how they contribute to the final performance of the RFQ.

  10. A toroidal trap for the cold $^{87}Rb$ atoms using a rf-dressed quadrupole trap

    CERN Document Server

    Chakraborty, A; Ram, S P; Tiwari, S K; Rawat, H S

    2015-01-01

    We demonstrate the trapping of cold $^{87}Rb$ atoms in a toroidal geometry using a rf-dressed quadrupole magnetic trap formed by superposing a strong radio frequency (rf) field on a quadrupole trap. This rf-dressed quadrupole trap has minimum of the potential away from the quadrupole trap centre on a circular path which facilitates the trapping in the toroidal geometry. In the experiments, the laser cooled atoms were first trapped in the quadrupole trap, then cooled evaporatively using a weak rf-field, and finally trapped in the rf-dressed quadrupole trap. The radius of the toroid could be varied by varying the frequency of the dressing rf-field. It has also been demonstrated that a single rf source and an antenna can be used for the rf-evaporative cooling as well as for rf-dressing of atoms. The atoms trapped in the toroidal trap may have applications in realization of an atom gyroscope as well as in studying the quantum gases in low dimensions.

  11. Use of RF quadrupole structures to enhance stability in accelerator rings

    CERN Document Server

    AUTHOR|(CDS)2091303; Grudiev, Alexej; Li, Kevin Shing Bruce; Papke, Kai

    2016-01-01

    The beams required for the high luminosity upgrade of the Large Hadron Collider (HL-LHC) at CERN call for efficient mechanisms to suppress transverse collective instabilities. In addition to octupole magnets installed for the purpose of Landau damping, we propose to use radio frequency (rf) quadrupole structures to considerably enhance the aforementioned stabilising effect. By means of the PyHEADTAIL macroparticle tracking code, the stabilising mechanism introduced by an rf quadrupole is studied and discussed. As a specific example, the performance of an rf quadrupole system in presence of magnetic octupoles is demonstrated for HL-LHC. Furthermore, potential performance limitations such as the excitation of synchro-betatron resonances are pointed out. Finally, efforts towards possible measurements with the CERN Super Proton Synchrotron (SPS) are discussed aiming at studying the underlying stabilising mechanisms experimentally.

  12. Superconducting Quadrupole Prototype for the ISR high luminosity (low beta) insertion

    CERN Multimedia

    1977-01-01

    In colliders, smaller beam cross-section means higher luminosity. Beam-size being proportional to the square-root of the "beta function" value, a small beta means small beam size, hence high luminosity. In 1973 a study was launched on low-beta insertions using superconducting quadrupole magnets, which focus beams to very small sizes at the beam crossing points . In 1976 the first prototype of a superconducting quadrupole was tested. Here we see Theodor Tortschanoff with the prototype of 1.25 m magnetic length. Manufacture of 8 quadrupoles (4 of L=1.15 m, 4 of L=0.65 m) began at Alsthom in 1978. They were installed at intersection I8 of the ISR, enhancing luminosity there by a factor 7 until final low-beta operation in December 1983. For details see "Yellow Report" CERN 76-16. See also pictures 7702307, 7702308, 7702182,7510214X,7510217X.

  13. Preliminary proposal of a Nb{sub 3}Sn quadrupole model for the low {beta} insertions of the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Ambrosio, G.; Ametrano, F.; Bellomo, G.; Broggi, F.; Rossi, L.; Volpini, G. [Milan Univ. (Italy). Dip. di Fisica]|[INFN, Sezione di Milano (Italy). Laboratorio Acceleratori e Superconduttivita` Applicata

    1995-09-01

    In recent years Nb{sub 3}Sn based conductors have shown wide applicability for superconducting magnets in many research areas like high field solenoids for laboratory experiment, for NMR spectroscopy and high field magnets for fusion. Nb{sub 3}Sn technology is progressing fast, increasing both technical reliability and availability. The Nb{sub 3}Sn technology, which has a higher critical field than NbTi, seems attractive for IR (Insertion Region) quadrupoles of large colliders . In this paper it is proposed the construction of a superconducting quadrupole wound with Nb{sub 3}Sn cable for a second generation IR inner triplet low {beta} quadrupoles, for the Large Hadron Collider at CERN. The low {beta} quadrupoles, control the beam focusing at collision points, therefore a gain in term of focus strength and/or coil aperture can increase significantly machine performance. Two are the main steps for the whole project: (1) design and construction of a 1 metre long quadrupole to demonstrate the actual feasibility, which is the subject of this proposal; (2) study for integration of the quadrupole in the machine and final design of 5 m long quadrupoles finalized to the LHC.

  14. Optimized Superconducting Quadrupole Arrays for Multiple Beam Transport

    Energy Technology Data Exchange (ETDEWEB)

    Meinke, Rainer, B.; Goodzeit, Carl, L.; Ball, Millicent, J.

    2005-09-20

    This research project advanced the development of reliable, cost-effective arrays of superconducting quadrupole magnets for use in multi-beam inertial fusion accelerators. The field in each array cell must be identical and meet stringent requirements for field quality and strength. An optimized compact array design using flat double-layer pancake coils was developed. Analytical studies of edge termination methods showed that it is feasible to meet the requirements for field uniformity in all cells and elimination of stray external field in several ways: active methods that involve placement of field compensating coils on the periphery of the array or a passive method that involves use of iron shielding.

  15. Low-frequency nuclear quadrupole resonance with a dc SQUID

    Energy Technology Data Exchange (ETDEWEB)

    Chang, J.W.

    1991-07-01

    Conventional pure nuclear quadrupole resonance (NQR) is a technique well suited for the study of very large quadrupolar interactions. Numerous nuclear magnetic resonance (NMR) techniques have been developed for the study of smaller quadrupolar interactions. However, there are many nuclei which have quadrupolar interactions of intermediate strength. Quadrupolar interactions in this region have traditionally been difficult or unfeasible to detect. This work describes the development and application of a SQUID NQR technique which is capable of measuring intermediate strength quadrupolar interactions, in the range of a few hundred kilohertz to several megahertz. In this technique, a dc SQUID (Superconducting QUantum Interference Device) is used to monitor the longitudinal sample magnetization, as opposed to the transverse magnetization, as a rf field is swept in frequency. This allows the detection of low-frequency nuclear quadrupole resonances over a very wide frequency range with high sensitivity. The theory of this NQR technique is discussed and a description of the dc SQUID system is given. In the following chapters, the spectrometer is discussed along with its application to the study of samples containing half-odd-integer spin quadrupolar nuclei, in particular boron-11 and aluminum-27. The feasibility of applying this NQR technique in the study of samples containing integer spin nuclei is discussed in the last chapter. 140 refs., 46 figs., 6 tabs.

  16. Low-frequency nuclear quadrupole resonance with a dc SQUID

    Science.gov (United States)

    Chang, J. W.

    1991-07-01

    Conventional pure nuclear quadrupole resonance (NQR) is a technique well suited for the study of very large quadrupolar interactions. Numerous nuclear magnetic resonance (NMR) techniques have been developed for the study of smaller quadrupolar interactions. However, there are many nuclei which have quadrupolar interactions of intermediate strength. Quadrupolar interactions in this region are traditionally difficult or unfeasible to detect. This work describes the development and application of a SQUID NQR technique which is capable of measuring intermediate strength quadrupolar interactions, in the range of a few hundred kilohertz to several megahertz. In this technique, a dc SQUID (Superconducting QUantum Interference Device) is used to monitor the longitudinal sample magnetization, as opposed to the transverse magnetization, as a RF field is swept in frequency. This allows the detection of low-frequency nuclear quadrupole resonances over a very wide frequency range with high sensitivity. The theory of this NQR technique is discussed and a description of the dc SQUID system is given. In the following chapters, the spectrometer is discussed along with its application to the study of samples containing half-odd-integer spin quadrupolar nuclei, in particular boron-11 and aluminum-27. The feasibility of applying this NQR technique in the study of samples containing integer spin nuclei is discussed in the last chapter.

  17. Beam-induced quench test of LHC main quadrupole

    CERN Document Server

    Priebe, A; Dehning, B; Effinger, E; Emery, J; Holzer, E B; Kurfuerst, C; Nebot Del Busto, E; Nordt, A; Sapinski, M; Steckert, J; Verweij, A; Zamantzas, C

    2011-01-01

    Unexpected beam loss might lead to a transition of the accelerator superconducting magnet to a normal conducting state. The LHC beam loss monitoring (BLM) system is designed to abort the beam before the energy deposited in the magnet coils reach a quench-provoking level. In order to verify the threshold settings generated by simulation, a series of beam-induced quench tests at various beam energies has been performed. The beam losses are generated by means of an orbital bump peaked in one of main quadrupole magnets (MQ). The analysis includes not only BLM data but also the quench protection system (QPS) and cryogenics data. The measurements are compared to Geant4 simulations of energy deposition inside the coils and corresponding BLM signal outside the cryostat.

  18. 磁珠细胞分选CD133+/CD44+前列腺癌干细胞的初步鉴定%Initial identification of CD133+/CD44+ prostate cancer stem cell through magnetic bead cell sorting

    Institute of Scientific and Technical Information of China (English)

    盛夏; 王德林; 李文宾; 罗照

    2013-01-01

    目的:通过磁珠细胞分选(magnetic bead cell sorting,MACS)方法从人前列腺癌细胞系PC-3中分选CD133+/CD44+干细胞,为进一步功能性研究奠定基础.方法:运用流式细胞仪(flow cytometry,FCM)检测MACS分选前后PC-3细胞膜上CD133和CD44表达情况;观察无血清培养成球情况,免疫荧光(immunofluorescenee,IF)表达情况;比较细胞在分选前后的形态学、增殖能力方面的差异;免疫组化(immunohistochemistry,IHC)和Western blot检测诱导分化前后前列腺酸性磷酸酶(prostatic acid phosphatase,PAP)蛋白情况.结果:FCM检测PC-3细胞CD133和CD44的阳性表达分别是(1.33±0.05)%和(0.87±0.06)%,而MACS分选后PAP分别为(84.82±0.07)%和(99.91±0.03)%;IF检测CD133+/CD44+细胞培养后继续呈阳性表达;CD133+/CD44+细胞增殖能力高于PC-3细胞(t=11.0,P=0.008)以及高于诱导后的CD133+/CD44+细胞(t=40.1,P=0.001);CD133+/CD44+细胞经过转化生长因子-β诱导后IHC和Western blot检测PAP表达呈阳性,而未诱导的CD133+/CD44+细胞表达呈阴性.结论:MACS从PC-3细胞株中分选的CD 133+/CD44+细胞经过初步功能性鉴定具有干细胞的某些特性,可为前列腺癌干细胞的进一步探索充当铺垫.

  19. 免疫磁珠法筛选人乳牙牙髓干细胞及其培养鉴定%Isolation and identification of stem cells derived from human exfoliated deciduous teeth by magnetic activated cell sorting

    Institute of Scientific and Technical Information of China (English)

    丁祥龙; 陈柯; 申元源

    2011-01-01

    目的 应用免疫磁珠法分离筛选人乳牙牙髓干细胞,并做培养鉴定.方法 采用STRO-1为标记物以免疫磁珠分离筛选人乳牙牙髓干细胞,观察细胞形态及生长情况,流式细胞仪检测细胞表型,并检测细胞体外多向分化能力.结果 应用免疫磁珠法筛选人乳牙牙髓细胞可获得乳牙牙髓于细胞,经统计学处理证明看其生长速度慢于牙髓细胞,细胞表型分析证实CD29、CD105高表达,CD34、CD45低表达.矿化诱导和成脂诱导证实STRO-1+乳牙牙髓细胞具有干细胞多向分化的能力.结论 免疫磁珠法是有效的分离纯化人乳牙牙髓干细胞的方法.所分离的细胞具有干细胞的表型特点及多向分化能力.%Objective To isolate stem cells from human exfoliated deciduous teeth (SHEDs) and identify their phenotypes and multi-lineage differentiation potential. Methods Human pulp tissue from exfoliated deciduous teeth were dissected and digested to obtain the single cell suspension. The SHEDs selected by magnetic activated cell sorting system (MACS) were identified by examination of the cell morphology and growth in vitro and detection of the expressions of the cell markers. Osteogenic and adipogenic induction was performed to test the multi-lineage differentiation potential of the cells. Results SHEDs were successfully isolated from human exfoliated deciduous teeth. SHEDs showed a lower growth rate than dental pulp cells and displayed high expressions of CD29 and CD105 but low expressions of CD34 and CD45 as shown by flow cytometry. Experiments of in vitro induction demonstrated a strong potential of the STRO-1+ SHEDs for osteogenic and adipogenic differentiation. Conclusion Immunomagnetic bead selection can be used to isolate and purify SHEDs, and the STRO-1+ SHEDs show the characteristics of stem cells with multipotent differentiation potentials.

  20. Mechanical behaviour of vacuum chambers and beam screens under quench conditions in dipole and quadrupole fields

    CERN Document Server

    Rathjen, C

    2002-01-01

    A method based on analytical formulas is described to calculate bending moments, stresses, and deformations of vacuum chambers and beam screens in dipole and in quadrupole fields during a magnet quench. Solutions are given for circular and racetrack shaped structures. Without the need of time consuming calculations the solutions enable a quick design and verification of vacuum chambers and beam screens.

  1. DESIGN OF A THIN QUADRUPOLE TO BE USED IN THE AGS SYNCHROTRON

    Energy Technology Data Exchange (ETDEWEB)

    TSOUPAS,N.; AHRENS, L.; ALFORQUE, R.; BAI, M.; BROWN, K.; COURANT, E.; ET AL.

    2007-06-25

    The Alternating Gradient Synchrotron (AGS) employs two partial helical snakes[l] to preserve the polarization of the proton beam during acceleration. In order to compensate for the focusing effect of the partial helical snakes on the beam optics in the AGS during acceleration of the beam, we introduced eight quadrupoles in straight sections of the AGS at the proximity of the partial snakes. At injection energies, the strength of each quad is set at a high value, and is ramped down to zero as the effect of the snakes diminishes by the square of beam's rigidity. Four of the eight compensation quadrupoles had to be placed in very short straight sections -30 cm in length, therefore the quadruples had be thin with an overall length of less than 30 cm. In this paper we will discus: (a) the mechanical and magnetic specifications of the ''thin'' quadrupole. (b) the method to minimize the strength of the dodecapole harmonic, (c) the method to optimize the thickness of the laminations that the magnet iron is made, (d) mechanical tolerances of the magnet, (e) comparison of the measured and calculated magnetic multipoles of the quadrupole.

  2. Superconducting Quadrupole for the ISR high luminosity insertion assembly in its cryostat

    CERN Multimedia

    1979-01-01

    The picture shows the insertion of the quadrupole magnet active part with its thermal shield into the cryostat. Above the cylindrical part of the cryostat one sees the funnel containing the current leads and the helium feed and exhaust lines. Standing onthe left side is Pierre Pugin. See also 7704022, 7906592X, 7812211,7904252,7702690X.

  3. ISR Superconducting Quadrupole in its cryostat

    CERN Multimedia

    1978-01-01

    The picture shows a superconducting quadrupole for the ISR high luminosity (low beta) insertion in its cryostat during final tests before installation in the ISR.The person is W.Burgess. See also photo 7702690X.

  4. Sex-sorting sperm using flow cytometry/cell sorting.

    Science.gov (United States)

    Garner, Duane L; Evans, K Michael; Seidel, George E

    2013-01-01

    The sex of mammalian offspring can be predetermined by flow sorting relatively pure living populations of X- and Y-chromosome-bearing sperm. This method is based on precise staining of the DNA of sperm with the nucleic acid-specific fluorophore, Hoechst 33342, to differentiate between the subpopulations of X- and Y-sperm. The fluorescently stained sperm are then sex-sorted using a specialized high speed sorter, MoFlo(®) SX XDP, and collected into biologically supportive media prior to reconcentration and cryopreservation in numbers adequate for use with artificial insemination for some species or for in vitro fertilization. Sperm sorting can provide subpopulations of X- or Y-bearing bovine sperm at rates in the 8,000 sperm/s range while maintaining; a purity of 90% such that it has been applied to cattle on a commercial basis. The sex of offspring has been predetermined in a wide variety of mammalian species including cattle, swine, horses, sheep, goats, dogs, cats, deer, elk, dolphins, water buffalo as well as in humans using flow cytometric sorting of X- and Y-sperm.

  5. Automated Sorting of Transuranic Waste

    Energy Technology Data Exchange (ETDEWEB)

    Shurtliff, Rodney Marvin

    2001-03-01

    The HANDSS-55 Transuranic Waste Sorting Module is designed to sort out items found in 55-gallon drums of waste as determined by an operator. Innovative imaging techniques coupled with fast linear motor-based motion systems and a flexible end-effector system allow the operator to remove items from the waste stream by a touch of the finger. When all desired items are removed from the waste stream, the remaining objects are automatically moved to a repackaging port for removal from the glovebox/cell. The Transuranic Waste Sorting Module consists of 1) a high accuracy XYZ Stereo Measurement and Imaging system, 2) a vibrating/tilting sorting table, 3) an XY Deployment System, 4) a ZR Deployment System, 5) several user-selectable end-effectors, 6) a waste bag opening system, 7) control and instrumentation, 8) a noncompliant waste load-out area, and 9) a Human/Machine Interface (HMI). The system is modular in design to accommodate database management tools, additional load-out ports, and other enhancements. Manually sorting the contents of a 55-gallon drum takes about one day per drum. The HANDSS-55 Waste Sorting Module is designed to significantly increase the throughput of this sorting process by automating those functions that are strenuous and tiresome for an operator to perform. The Waste Sorting Module uses the inherent ability of an operator to identify the items that need to be segregated from the waste stream and then, under computer control, picks that item out of the waste and deposits it in the appropriate location. The operator identifies the object by locating the visual image on a large color display and touches the image on the display with his finger. The computer then determines the location of the object, and performing a highspeed image analysis determines its size and orientation, so that a robotic gripper can be deployed to pick it up. Following operator verification by voice or function key, the object is deposited into a specified location.

  6. The physics of quadrupole interactions in crystals. Quadrupole interactions observed in the 1{sup +} {yields} 0{sup +}{gamma}-ray transition

    Energy Technology Data Exchange (ETDEWEB)

    Goldting, G. [Weizmann Inst. of Science, Rehovoth (Israel); Anderssen, S.S.; Lane, G.J. [Australian National Univ., Canberra, ACT (Australia). Research School of Physical Sciences

    1995-11-01

    For many people the nuclear interaction with the electric quadrupole is not as easily understood as the magnetic dipole interaction. This is partly due to the use of Racah algebra in conventional quadrupole interaction calculations. Although this is a powerful technique that provides a neat summation over the m-substates of both the initial nuclear state and the emitted radiation, the formalism does tend to `hide` some of the details and interesting features of the interaction. Therefore, to improve our understanding of these processes with an emphasis on the physical characteristics, these notes will detail the calculation of quadrupole interactions with both polarised and aligned nuclei without using Racah algebra. To make these calculations manageable only the 1{sup +}{yields} 0{sup +}{gamma}-ray transition is considered. The J{sup {pi}} =1{sup +} state has only 3 substates (m = -1,0,+1), and the parity and angular momentum selection rules allow only M1 magnetic dipole transitions. The calculation has led to some explanations of the difference between the aligned and polarized quadrupole interactions, which is the orientation of the quantization axis with respect to the equatorial plane.

  7. Design and Manufacture of a Hybrid Final Focus Quadrupole Model for CLIC

    CERN Document Server

    Modena, Michele; Vorozhtsov, Alexey

    2012-01-01

    A tunable hybrid quadrupole magnet design has been proposed for the final focus in the Compact Linear Collider (CLIC) that is currently under study. The proposed design is a combination of an iron dominated electromagnetic quadrupole with a bore diameter of 8.25 mm with permanent magnet blocks placed between the poles made of soft magnetic CoFe alloy "Permendur". The possibility of using Sm2Co17 and Nd2Fe14B as material for the permanent magnet blocks has been investigated. It is shown that a very high field gradient of 530 T/m (Sm2Co17) and 590 T/m (Nd2Fe14B) can be achieved.

  8. Field Quality and Alignment of the Series Produced Superconducting Matching Quadrupoles for the LHC Insertions

    CERN Document Server

    Catalan-Lasheras, Nuria; Kirby, Glyn; Ostojic, Ranko; Perez, Juan C; Prin, Herve

    2005-01-01

    The production of the superconducting quadrupoles for the LHC insertions is advancing well and about half of the magnets have been produced. The coil size and field measurements performed on individual magnets both in warm and cold conditions are yielding significant results. In this paper we present the procedures and results of steering the series production at the magnet manufacturers and the assembly of cold masses at CERN. In particular, we present the correlation between coil sizes and geometrical field errors, the effect of permeability of magnet collars, and the analysis of warm-cold correlations and hysteresis of the main field multipoles. The results are compared with the target values for field multipoles and quadrupole alignment.

  9. Performance of the first short model 150 mm aperture Nb$_3$Sn Quadrupole MQXFS for the High-Luminosity LHC upgrade

    CERN Document Server

    Chlachidze, G; Anerella, M; Bossert, R; Cavanna, E; Cheng, D; Dietderich, D; DiMarco, J; Felice, H; Ferracin, P; Ghosh, A; Grosclaude, P; Guinchard, M; Hafalia, A R; Holik, E; Izquierdo Bermudez, S; Krave, S; Marchevsky, M; Nobrega, F; Orris, D; Pan, H; Perez, J C; Prestemon, S; Ravaioli, E; Sabbi, G L; Salmi, T; Schmalzle, J; Stoynev, S; Strauss, T; Sylvester, C; Tartaglia, M; Todesco, E; Vallone, G; Velev, G; Wanderer, P; Wang, X; Yu, M

    2016-01-01

    The US LHC Accelerator Research Program (LARP) and CERN combined their efforts in developing Nb3Sn magnets for the High-Luminosity LHC upgrade. The ultimate goal of this collaboration is to fabricate large aperture Nb3Sn quadrupoles for the LHC interaction regions (IR). These magnets will replace the present 70 mm aperture NbTi quadrupole triplets for expected increase of the LHC peak luminosity by a factor of 5. Over the past decade LARP successfully fabricated and tested short and long models of 90 mm and 120 mm aperture Nb3Sn quadrupoles. Recently the first short model of 150 mm diameter quadrupole MQXFS was built with coils fabricated both by the LARP and CERN. The magnet performance was tested at Fermilab’s vertical magnet test facility. This paper reports the test results, including the quench training at 1.9 K, ramp rate and temperature dependence studies.

  10. Sorting and selection in posets

    DEFF Research Database (Denmark)

    Daskalakis, Constantinos; Karp, Richard M.; Mossel, Elchanan

    2011-01-01

    Classical problems of sorting and searching assume an underlying linear ordering of the objects being compared. In this paper, we study these problems in the context of partially ordered sets, in which some pairs of objects are incomparable. This generalization is interesting from a combinatorial...

  11. VIBRATION MEASUREMENTS IN A RHIC QUADRUPOLE AT CRYOGENIC TEMPERATURES.

    Energy Technology Data Exchange (ETDEWEB)

    JAIN, A.; AYDIN, S.; HE, P.; ANERELLA, M.; GANETIS, G.; HARRISON, M.; PARKER, B.; PLATE, S.

    2005-10-17

    One of the concerns in using compact superconducting magnets in the final focus region of the ILC is the influence of the cryogen flow on the vibration characteristics. As a first step towards characterizing such motion at nanometer levels, a project was undertaken at BNL to measure the vibrations in a spare RHIC quadrupole under cryogenic conditions. Given the constraints of cryogenic operation, and limited space available, it was decided to use a dual head laser Doppler vibrometer for this work. The performance of the laser vibrometer was tested in a series of room temperature tests and compared with results from Mark L4 geophones. The laser system was then used to measure the vibration of the cold mass of the quadrupole with respect to the outside warm enclosure. These measurements were carried out both with and without the flow of cold helium through the magnet. The results indicate only a minor increase in motion in the horizontal direction (where the cold mass is relatively free to move).

  12. Alternative Mechanical Structure for LARP Nb3Sn Quadrupoles

    Energy Technology Data Exchange (ETDEWEB)

    Anerella, M.; Cozzolino, J.; Ambrosio, G.; Caspi, S.; Felice, H.; Kovach, P.; Lamm, M.; Sabbi, G.; Schmalzle, J.; Wanderer, P.

    2010-08-01

    An alternative structure for the 120 mm Nb{sub 3}Sn quadrupole magnet presently under development for use in the upgrade for LHC at CERN is presented. The goals of this structure are to build on the existing technology developed in LARP with the LQ and HQ series magnets and to further optimize the features required for operation in the accelerator. These features include mechanical alignment needed for field quality and provisions for cold mass cooling with 1.9 K helium in a helium pressure vessel. The structure will also optimize coil azimuthal and axial pre-load for high gradient operation, and will incorporate features intended to improve manufacturability, thereby improving reliability and reducing cost.

  13. Series fabrication of the main quadrupole cold masses for the LHC begins

    CERN Multimedia

    2003-01-01

    Three hundred and sixty main quadrupole (MQ) magnets will perform the principal beam focusing around the 27 km LHC ring. CERN and CEA-Saclay began collaborating on the development and prototyping of these magnets in 1989. This resulted in five highly successful quadrupole units - also known as short straight sections - one of which was integrated for testing in String 1, and two others of the final design in String 2. Once the tests had confirmed the validity of the design and realization, the fabrication of the 360 cold masses had to be transferred to industry.The German firm ACCEL Instruments was entrusted both with the construction of the quadrupole magnets themselves, and with their assembly into the cold masses together with various combinations of corrector magnets produced by other European manufacturers. Here we see the first of the cold masses containing the MQ magnet of the machine arcs together with two types of corrector magnet ready for shipping to CERN. Pictured with this first unit, delivered o...

  14. Series fabrication of the main quadrupole cold masses for the LHC begins

    CERN Multimedia

    2003-01-01

    Three hundred and sixty main quadrupole (MQ) magnets will perform the principal beam focusing around the 27 km LHC ring. CERN and CEA-Saclay began collaborating on the development and prototyping of these magnets in 1989. This resulted in five highly successful quadrupole units - also known as short straight sections - one of which was integrated for testing in String 1, and two others of the final design in String 2. Once the tests had confirmed the validity of the design and realization, the fabrication of the 360 cold masses had to be transferred to industry.The German firm ACCEL Instruments was entrusted both with the construction of the quadrupole magnets themselves, and with their assembly into the cold masses together with various combinations of corrector magnets produced by other European manufacturers. Here we see the first of the cold masses containing the MQ magnet of the machine arcs together with two types of corrector magnet ready for shipping to CERN. This first unit was delivered on 12 Februa...

  15. Radiation and Thermal Analysis of Superconducting Quadrupoles in the Interaction Region of Linear Collider

    Energy Technology Data Exchange (ETDEWEB)

    Drozhdin, A.I.; Kashikhin, V.V.; Kashikhin, V.S.; Lopes, M.L.; Mokhov, N.V.; Zlobin, A.V.; /Fermilab; Seryi, Andrei; /SLAC

    2011-10-14

    Radiation heat deposition in the superconducting magnets of the Interaction Region (IR) of a linear collider can be a serious issue that limits the magnet operating margins and shortens the material lifetime. Radiation and thermal analyses of the IR quadrupoles in the incoming and extraction beam lines of the ILC are performed in order to determine the magnet limits. This paper presents an analysis of the radial, azimuthal and longitudinal distributions of heat deposition in the incoming and disrupted beam doublets. Operation margins of the magnets based on NbTi superconductor are calculated and compared. The radiation and thermal analysis of the ILC IR quadrupoles based on Rutherford type cables was performed. It was found that the peak radiation heat deposition takes place in the second extraction quadrupole QFEX2. The maximum power density in the coil is {approx}17mW/g. This is rather high, comparing to the proton machines (LHC). However, the fast radial decay of the heat deposition together with the high thermal conductivity of the Rutherford type cable limits the coil temperatures to a moderate level. It was determined that both 2-layer and 4-layer QFEX2 magnet designs have thermal margins of a factor of {approx}4 at the nominal gradient of 31.3 T/m. Because of the large margins, these magnets can easily accommodate possible changes in the IR optics and heat deposition levels.

  16. Immunomagnetic Indirect Positive Sorting of Precartilaginous Stem Cells from Neonatal Rat

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    To investigate the technique of sorting high-purity precartilaginous stem cells from rat's perichondrium, neonatal rat's perichondrium cells suspensions were incubated with monoclone antibody of anti-fibroblast growth factor receptor-3 (anti-FGFR-3), and the labeled cells were separated from the suspension in the magnetic field by immuno-beads coated with the second antibody. Purityof the sorted neural stem cells was found to be 93.0 %-99.0 %, with living cells amounting to 80 %-85 %. The magnetic cell sorting system could effectively separate precartilaginous stem cells fromperichondrium cell suspensions.

  17. Origin-independent calculation of quadrupole intensities in X-ray spectroscopy

    CERN Document Server

    Bernadotte, Stephan; Jacob, Christoph R

    2012-01-01

    For electronic excitations in the ultraviolet and visible range of the electromagnetic spectrum, the intensities are usually calculated within the dipole approximation, which assumes that the oscillating electric field is constant over the whole molecule. For the short wavelengths used in X-ray spectroscopy, this dipole approximation breaks down and it becomes necessary to include higher-order contributions. In quantum-chemical approaches to X-ray spectroscopy, these so-called quadrupole intensities have so far been calculated by including contributions depending on the square of the electric-quadrupole and magnetic-dipole transition moments. However, the resulting quadrupole intensities depend on the choice of the origin of the coordinate system. Here, we show that for obtaining an origin-independent theory, one has to include all contributions that are of the same order in the wave vector consistently. This leads to two additional contributions depending on products of the electric-dipole and electric-octup...

  18. Sorting cells by their density

    Science.gov (United States)

    Norouzi, Nazila; Bhakta, Heran C.

    2017-01-01

    Sorting cells by their type is an important capability in biological research and medical diagnostics. However, most cell sorting techniques rely on labels or tags, which may have limited availability and specificity. Sorting different cell types by their different physical properties is an attractive alternative to labels because all cells intrinsically have these physical properties. But some physical properties, like cell size, vary significantly from cell to cell within a cell type; this makes it difficult to identify and sort cells based on their sizes alone. In this work we continuously sort different cells types by their density, a physical property with much lower cell-to-cell variation within a cell type (and therefore greater potential to discriminate different cell types) than other physical properties. We accomplish this using a 3D-printed microfluidic chip containing a horizontal flowing micron-scale density gradient. As cells flow through the chip, Earth’s gravity makes each cell move vertically to the point where the cell’s density matches the surrounding fluid’s density. When the horizontal channel then splits, cells with different densities are routed to different outlets. As a proof of concept, we use our density sorter chip to sort polymer microbeads by their material (polyethylene and polystyrene) and blood cells by their type (white blood cells and red blood cells). The chip enriches the fraction of white blood cells in a blood sample from 0.1% (in whole blood) to nearly 98% (in the output of the chip), a 1000x enrichment. Any researcher with access to a 3D printer can easily replicate our density sorter chip and use it in their own research using the design files provided as online Supporting Information. Additionally, researchers can simulate the performance of a density sorter chip in their own applications using the Python-based simulation software that accompanies this work. The simplicity, resolution, and throughput of this

  19. LHC Magnet Assembly Facility in building 181

    CERN Multimedia

    CERN Video Productions

    2005-01-01

    Hall 181 activities for the LHC machine * Reception of the American magnets : quadrupoles and separation dipoles * Assembly of the string Low-Beta Triplet -Q2-Q3-DFBX-D1 * Insertion quadrupoles cold masses assembly * Magnets reception type MQM, MQY, MCBC et MCBY * Assembly in the shell * Longitudinal welding under the press * Equipment with end covers in the finishing area

  20. Magnetic stripping studies for SPL

    CERN Document Server

    Posocco, P; CERN. Geneva. BE Department

    2010-01-01

    Magnetic stripping of H- can seriously enhance the beam losses along the SPL machine. These losses depend on the beam energy, on the beam transverse distribution and on the intensity of the magnetic field. For radioprotection issues the losses must be limited to 1 W/m. In this paper we will concentrate on the stripping phenomena inside the quadrupole magnets with the aim of defining the quadrupole range for the design phase of SPL.

  1. Simple expressions of the nuclear relaxation rate enhancement due to quadrupole nuclei in slowly tumbling molecules

    Energy Technology Data Exchange (ETDEWEB)

    Fries, Pascal H., E-mail: pascal-h.fries@cea.fr [Université Grenoble Alpes, INAC-SCIB, RICC, F-38000 Grenoble (France); CEA, INAC-SCIB, RICC, F-38000 Grenoble (France); Belorizky, Elie [Université Grenoble Alpes, LIPHY, F-38000 Grenoble (France); CEA, Leti-Clinatec, F-38000 Grenoble (France)

    2015-07-28

    For slowly tumbling entities or quasi-rigid lattices, we derive very simple analytical expressions of the quadrupole relaxation enhancement (QRE) of the longitudinal relaxation rate R{sub 1} of nuclear spins I due to their intramolecular magnetic dipolar coupling with quadrupole nuclei of arbitrary spins S ≥ 1. These expressions are obtained by using the adiabatic approximation for evaluating the time evolution operator of the quantum states of the quadrupole nuclei S. They are valid when the gyromagnetic ratio of the spin S is much smaller than that of the spin I. The theory predicts quadrupole resonant peaks in the dispersion curve of R{sub 1} vs magnetic field. The number, positions, relative intensities, Lorentzian shapes, and widths of these peaks are explained in terms of the following properties: the magnitude of the quadrupole Hamiltonian and the asymmetry parameter of the electric field gradient (EFG) acting on the spin S, the S-I inter-spin orientation with respect to the EFG principal axes, the rotational correlation time of the entity carrying the S–I pair, and/or the proper relaxation time of the spin S. The theory is first applied to protein amide protons undergoing dipolar coupling with fast-relaxing quadrupole {sup 14}N nuclei and mediating the QRE to the observed bulk water protons. The theoretical QRE agrees well with its experimental counterpart for various systems such as bovine pancreatic trypsin inhibitor and cartilages. The anomalous behaviour of the relaxation rate of protons in synthetic aluminium silicate imogolite nano-tubes due to the QRE of {sup 27}Al (S = 5/2) nuclei is also explained.

  2. Focusing properties of discrete RF quadrupoles

    Science.gov (United States)

    Li, Zhi-Hui; Wang, Zhi-Jun

    2017-08-01

    The particle motion equation for a Radio Frequency (RF) quadrupole is derived. The motion equation shows that the general transform matrix of a RF quadrupole with length less than or equal to 0.5βλ (β is the relativistic velocity of particles and λ is wavelength of radio frequency electromagnetic field) can describe the particle motion in an arbitrarily long RF quadrupole. By iterative integration, the general transform matrix of a discrete RF quadrupole is derived from the motion equation. The transform matrix is in form of a power series of focusing parameter B. It shows that for length less than βλ, the series up to the 2nd order of B agrees well with the direct integration results for B up to 30, while for length less than 0.5βλ, the series up to 1st order is already a good approximation of the real solution for B less than 30. The formula of the transform matrix can be integrated into linac or beam line design code to deal with the focusing of discrete RF quadrupoles. Supported by National Natural Science Foundation of China (11375122, 11511140277) and Strategic Priority Research Program of the Chinese Academy of Sciences (XDA03020705)

  3. ASSEMBLY AND TEST OF A 120 MM BORE 15 T NB3SN QUADRUPOLE FOR THE LHC UPGRADE

    Energy Technology Data Exchange (ETDEWEB)

    Felice, H.; Caspi, S.; Cheng, D.; Dietderich, D.; Ferracin, P.; Hafalia, R.; Joseph, J.; Lizarazo, J.; Sabbi, G. L.; Wang, X.; Anerella, M.; Ghosh, A. K.; Schmalzle, J.; Wanderer, P.; Ambrosio, G.; Bossert, R.; Zlobin, A. V.

    2010-05-23

    In support of the Large Hadron Collider (LHC) luminosity upgrade, the US LHC Accelerator Research Program (LARP) has been developing a 1-meter long, 120 mm bore Nb{sub 3}Sn IR quadrupole magnet (HQ). With a design short sample gradient of 219 T/m at 1.9 K and a peak field approaching 15 T, one of the main challenges of this magnet is to provide appropriate mechanical support to the coils. Compared to the previous LARP Technology Quadrupole and Long Quadrupole magnets, the purpose of HQ is also to demonstrate accelerator quality features such as alignment and cooling. So far, 8 HQ coils have been fabricated and 4 of them have been assembled and tested in HQ01a. This paper presents the mechanical assembly and test results of HQ01a.

  4. Swarm-Based Spatial Sorting

    CERN Document Server

    Amos, Martyn

    2008-01-01

    Purpose: To present an algorithm for spatially sorting objects into an annular structure. Design/Methodology/Approach: A swarm-based model that requires only stochastic agent behaviour coupled with a pheromone-inspired "attraction-repulsion" mechanism. Findings: The algorithm consistently generates high-quality annular structures, and is particularly powerful in situations where the initial configuration of objects is similar to those observed in nature. Research limitations/implications: Experimental evidence supports previous theoretical arguments about the nature and mechanism of spatial sorting by insects. Practical implications: The algorithm may find applications in distributed robotics. Originality/value: The model offers a powerful minimal algorithmic framework, and also sheds further light on the nature of attraction-repulsion algorithms and underlying natural processes.

  5. Sorting fluorescent nanocrystals with DNA

    Energy Technology Data Exchange (ETDEWEB)

    Gerion, Daniele; Parak, Wolfgang J.; Williams, Shara C.; Zanchet, Daniela; Micheel, Christine M.; Alivisatos, A. Paul

    2001-12-10

    Semiconductor nanocrystals with narrow and tunable fluorescence are covalently linked to oligonucleotides. These biocompounds retain the properties of both nanocrystals and DNA. Therefore, different sequences of DNA can be coded with nanocrystals and still preserve their ability to hybridize to their complements. We report the case where four different sequences of DNA are linked to four nanocrystal samples having different colors of emission in the range of 530-640 nm. When the DNA-nanocrystal conjugates are mixed together, it is possible to sort each type of nanoparticle using hybridization on a defined micrometer -size surface containing the complementary oligonucleotide. Detection of sorting requires only a single excitation source and an epifluorescence microscope. The possibility of directing fluorescent nanocrystals towards specific biological targets and detecting them, combined with their superior photo-stability compared to organic dyes, opens the way to improved biolabeling experiments, such as gene mapping on a nanometer scale or multicolor microarray analysis.

  6. Sorting Techniques for Plastics Recycling

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    This paper presents the basic principles of three different types of separating methods and a general guideline for choosing the most effective method for sorting plastic mixtures. It also presents the results of the tests carried out for separation of PVC, ABS and PET from different kinds of plastic mixtures in order to improve the grade of the raw input used in mechanical or feedstock recycling.

  7. Sorting of Sperm by Morphology

    Science.gov (United States)

    Koh, James; Marcos, Marcos

    2016-11-01

    Many studies have proven that the percentage of morphologically normal sperm is a significant factor in determining the success of assisted reproduction. The velocity of sperm in a microchannel with shear flow subjected to an external field will be explored theoretically. The difference in response between morphologically normal and abnormal sperm will be computed from a statistical approach, to study the feasibility and effectiveness of sorting by an external field to remove abnormal sperm. The full name of this author is Marcos.

  8. Self-sorting molecular clips.

    Science.gov (United States)

    Ghosh, Soumyadip; Wu, Anxin; Fettinger, James C; Zavalij, Peter Y; Isaacs, Lyle

    2008-08-01

    We report the synthesis and characterization of 12 C-shaped methylene-bridged glycoluril dimers (1-12) bearing H-bonding groups on their aromatic rings. Compounds 1, 2, (+/-)-4a, (+/-)-5, (+/-)-7, and 8 form tightly associated homodimers in CDCl3, due to the combined driving force of pi-pi and H-bonding interactions. Compounds 2, (+/-)-5, and 8, having disparate spatial distribution of their H-bonding groups, display the ability to efficiently distinguish between self and nonself even within three-component mixtures in CDCl3. When the spatial distributions of the H-bonding groups of the molecular clips are similar (e.g., 1 and 2), a mixture of homodimers and heterodimers is formed. The effect of various structural modifications (e.g., chirality, side chain steric bulk, number and pattern of H-bonds) on the strength of self-assembly and the fidelity of self-sorting are presented. On the basis of these results we prepared self-sorting systems comprising three (e.g., 1, (+/-)-5, and (+/-)-7) and even four ( 2, (+/-)-5, 9, and 10) components. The potential of molecular clips 1-12 as robust, functionalizable, self-sorting modules to control the noncovalent interaction network in systems chemistry studies is described.

  9. Flow cytometry and cell sorting.

    Science.gov (United States)

    Ibrahim, Sherrif F; van den Engh, Ger

    2007-01-01

    Flow cytometry and cell sorting are well-established technologies in clinical diagnostics and biomedical research. Heterogeneous mixtures of cells are placed in suspension and passed single file across one or more laser interrogation points. Light signals emitted from the particles are collected and correlated to entities such as cell morphology, surface and intracellular protein expression, gene expression, and cellular physiology. Based on user-defined parameters, individual cells can then be diverted from the fluid stream and collected into viable, homogeneous fractions at exceptionally high speeds and a purity that approaches 100%. As such, the cell sorter becomes the launching point for numerous downstream studies. Flow cytometry is a cornerstone in clinical diagnostics, and cheaper, more versatile machines are finding their way into widespread and varied uses. In addition, advances in computing and optics have led to a new generation of flow cytometers capable of processing cells at orders of magnitudes faster than their predecessors, and with staggering degrees of complexity, making the cytometer a powerful discovery tool in biotechnology. This chapter will begin with a discussion of basic principles of flow cytometry and cell sorting, including a technical description of factors that contribute to the performance of these instruments. The remaining sections will then be divided into clinical- and research-based applications of flow cytometry and cell sorting, highlighting salient studies that illustrate the versatility of this indispensable technology.

  10. Vibration Measurements to Study the Effect of Cryogen Flow in Superconducting Quadrupole.

    Energy Technology Data Exchange (ETDEWEB)

    He,P.; Anerella, M.; aydin, S.; Ganetis, G. Harrison, M.; Jain, A.; Parker, B.

    2007-06-25

    The conceptual design of compact superconducting magnets for the International Linear Collider final focus is presently under development. A primary concern in using superconducting quadrupoles is the potential for inducing additional vibrations from cryogenic operation. We have employed a Laser Doppler Vibrometer system to measure the vibrations in a spare RHIC quadrupole magnet under cryogenic conditions. Some preliminary results of these studies were limited in resolution due to a rather large motion of the laser head as well as the magnet. As a first step towards improving the measurement quality, a new set up was used that reduces the motion of the laser holder. The improved setup is described, and vibration spectra measured at cryogenic temperatures, both with and without helium flow, are presented.

  11. Word Sorts for General Music Classes

    Science.gov (United States)

    Cardany, Audrey Berger

    2015-01-01

    Word sorts are standard practice for aiding children in acquiring skills in English language arts. When included in the general music classroom, word sorts may aid students in acquiring a working knowledge of music vocabulary. The author shares a word sort activity drawn from vocabulary in John Lithgow's children's book "Never Play…

  12. Resonance methods in quadrupole ion traps

    Science.gov (United States)

    Snyder, Dalton T.; Peng, Wen-Ping; Cooks, R. Graham

    2017-01-01

    The quadrupole ion trap is widely used in the chemical physics community for making measurements on dynamical systems, both intramolecular (e.g. ion fragmentation reactions) and intermolecular (e.g. ion/molecule reactions). In this review, we discuss linear and nonlinear resonances in quadrupole ion traps, an understanding of which is critical for operation of these devices and interpretation of the data which they provide. The effect of quadrupole field nonlinearity is addressed, with important implications for promoting fragmentation and achieving unique methods of mass scanning. Methods that depend on ion resonances (i.e. matching an external perturbation with an ion's induced frequency of motion) are discussed, including ion isolation, ion activation, and ion ejection.

  13. A Nb-Ti 90 mm Double-Aperture Quadrupole for the High Luminosity LHC Upgrade

    CERN Document Server

    Segreti, M; Todesco, E

    2015-01-01

    The luminosity upgrade of the LHC requires replacing the magnets around the ATLAS and CMS experiments with larger aperture dipoles, quadrupoles and correctors. The goal is to have a magnetic lattice that can allow to halve the beam size in the collision points with respect to present baseline. Within the framework of HiLumi LHC, CEA-Saclay studied the replacement of the 70-mm double aperture quadrupole Q4, with a 90-mm magnet based on Nb-Ti technology. The main challenges are due to the distance between the beams of 194 mm, giving a non-negligible magnetic coupling between the two apertures. The coil chosen to be the baseline is a single layer with 15-mm-width cable of the LHC MQ quadrupole. The mechanical structure is based on stainless steel collars to withstand the Lorentz forces. The iron yoke has a magnetic function, and guarantees the alignment of the two apertures. Electromagnetic and mechanical aspects and effects of unbalanced regimes on the field quality have been analyzed. A 3-D design of the coil ...

  14. Continuous Size-Dependent Sorting of Ferromagnetic Nanoparticles in Laser-Ablated Microchannel

    Directory of Open Access Journals (Sweden)

    Yiqiang Fan

    2016-01-01

    Full Text Available This paper reports a low-cost method of continuous size-dependent sorting of magnetic nanoparticles in polymer-based microfluidic devices by magnetic force. A neodymium permanent magnet was used to generate a magnetic field perpendicular to the fluid flow direction. Firstly, FeNi3 magnetic nanoparticles were chemically synthesized with diameter ranges from 80 nm to 200 nm; then, the solution of magnetic nanoparticles and a buffer were passed through the microchannel in laminar flow; the magnetic nanoparticles were deflected from the flow direction under the applied magnetic field. Nanoparticles in the microchannel will move towards the direction of high-gradient magnetic fields, and the degree of deflection depends on their sizes; therefore, magnetic nanoparticles of different sizes can be separated and finally collected from different output ports. The proposed method offers a rapid and continuous approach of preparing magnetic nanoparticles with a narrow size distribution from an arbitrary particle size distribution. The proposed new method has many potential applications in bioanalysis field since magnetic nanoparticles are commonly used as solid support for biological entities such as DNA, RNA, virus, and protein. Other than the size sorting application of magnetic nanoparticles, this approach could also be used for the size sorting and separation of naturally magnetic cells, including blood cells and magnetotactic bacteria.

  15. Analytical transfer matrix of a quadrupole fringe

    Institute of Scientific and Technical Information of China (English)

    PENG Yue-Mei; XU Gang

    2011-01-01

    The analytical linear transfer matrices for different quadrupole fringes including quadratic,high order power and exponential models are deduced in this paper.As an example,the transfer matrices of the quadrupole BEPC Ⅱ 105Q are computed for the above three models and compared with hard edge and sliceby-slice models in cases of near 60° and 90° FODO cells.These models' results are much better than the hard edge model's,and can meet the requirement of accurate calculation.

  16. Rotating-coil calibration in a reference quadrupole, considering roll-angle misalignment and higher-order harmonics

    CERN Document Server

    Arpaia, Pasquale; Köster, Oliver; Russenschuck, Stephan; Severino, Giordana; 10.1016/j.measurement.2016.02.061

    2016-01-01

    A method is proposed for calibrating the radius of a rotating coil sensor by relaxing the metrological constraints on alignment and field errors of the reference quadrupole. A coil radius calibration considering a roll-angle misalignment of the measurement bench, the magnet, and the motor-drive unit is analyzed. Then, the error arising from higher-order harmonic field imperfections in the reference quadrupole is assessed. The method is validated by numerical field computation for both the higher-order harmonic errors and the roll-angle misalignment. Finally, an experimental proof-of-principle demonstration is car-ried out in a calibration magnet with sextupole harmonic.

  17. How does the Shift-insertion sort behave when the sorting elements follow a Normal distribution?

    CERN Document Server

    Pal, Mita; Mahanti, N C

    2012-01-01

    The present paper examines the behavior of Shift-insertion sort (insertion sort with shifting) for normal distribution inputs and is in continuation of our earlier work on this new algorithm for discrete distribution inputs, namely, negative binomial. Shift insertion sort is found more sensitive for main effects but not for all interaction effects compared to conventional insertion sort.

  18. Magnet production for the LHC is complete!

    CERN Multimedia

    2006-01-01

    On 27 November, the LHC teams celebrated the end of production of the machine's main magnets. Some 1232 main dipole and 392 main quadrupole magnets have been manufactured in an unprecedented collaboration effort between CERN and European industry.

  19. Performance of the LHC Arc Superconducting Quadrupoles Towards the End of their Series Fabrication

    CERN Document Server

    Tortschanoff, Theodor; Durante, M; Hagen, P; Klein, U; Krischel, D; Modena, M; Payn, A; Rossi, L; Sanfilippo, S; Schellong, B; Schirm, KM; Schmidt, P; Simon, F; Todesco, E; Wildner, E

    2006-01-01

    The fabrication of the 408 main arc quadrupole magnets and their cold masses will come to an end in summer 2006. A rich collection of measurement and test data has been accumulated and their analysis is presented in this paper. These data cover the fabrication and the efficiency in the use of the main components, the geometrical measurements and the achieved dimensional precision, the warm magnetic measurements in the factory and the performance at cold conditions, especially the training behaviour. The scrap rate of the Nb-Ti/Cu conductor as well as that of other components turned out to be acceptably low and the quench performance measured was in general very good. Most quadrupoles measured so far exceeded the operating field gradient with one or no quench. The multipole content at cold was measured for a limited number of quadrupoles in order to verify the warm-to-cold correlation. From the point of view of field quality, all quadrupoles could be accepted for the machine. The measures taken to overcome the...

  20. Extracting the Omega- electric quadrupole moment from lattice QCD data

    CERN Document Server

    Ramalho, G

    2010-01-01

    The Omega- has an extremely long lifetime, and is the most stable of the baryons with spin 3/2. Therefore the Omega- magnetic moment is very accurately known. Nevertheless, its electric quadrupole moment was never measured, although estimates exist in different formalisms. In principle, lattice QCD simulations provide at present the most appropriate way to estimate the Omega- form factors, as function of the square of the transferred four-momentum, Q2, since it describes baryon systems at the physical mass for the strange quark. However, lattice QCD form factors, and in particular GE2, are determined at finite Q2 only, and the extraction of the electric quadrupole moment, Q_Omega= GE2(0) e/(2 M_Omega), involves an extrapolation of the numerical lattice results. In this work we reproduce the lattice QCD data with a covariant spectator quark model for Omega- which includes a mixture of S and two D states for the relative quark-diquark motion. Once the model is calibrated, it is used to determine Q_Omega. Our pr...

  1. Extracting the Omega- electric quadrupole moment from lattice QCD data

    Energy Technology Data Exchange (ETDEWEB)

    G. Ramalho, M.T. Pena

    2011-03-01

    The Omega- has an extremely long lifetime, and is the most stable of the baryons with spin 3/2. Therefore the Omega- magnetic moment is very accurately known. Nevertheless, its electric quadrupole moment was never measured, although estimates exist in different formalisms. In principle, lattice QCD simulations provide at present the most appropriate way to estimate the Omega- form factors, as function of the square of the transferred four-momentum, Q2, since it describes baryon systems at the physical mass for the strange quark. However, lattice QCD form factors, and in particular GE2, are determined at finite Q2 only, and the extraction of the electric quadrupole moment, Q_Omega= GE2(0) e/(2 M_Omega), involves an extrapolation of the numerical lattice results. In this work we reproduce the lattice QCD data with a covariant spectator quark model for Omega- which includes a mixture of S and two D states for the relative quark-diquark motion. Once the model is calibrated, it is used to determine Q_Omega. Our prediction is Q_Omega= (0.96 +/- 0.02)*10^(-2) efm2 [GE2(0)=0.680 +/- 0.012].

  2. Polarized sorting and trafficking in epithelial cells

    Institute of Scientific and Technical Information of China (English)

    Xinwang Cao; Michal A Surma; Kai Simons

    2012-01-01

    The polarized distribution of proteins and lipids at the surface membrane of epithelial cells results in the formation of an apical and a basolateral domain,which are separated by tight junctions.The generation and maintenance of epithelial polarity require elaborate mechanisms that guarantee correct sorting and vectorial delivery of cargo molecules.This dynamic process involves the interaction of sorting signals with sorting machineries and the formation of transport carriers.Here we review the recent advances in the field of polarized sorting in epithelial cells.We especially highlight the role of lipid rafts in apical sorting.

  3. Triple quadrupole tandem mass spectrometry: A real alternative to high resolution magnetic sector instrument for the analysis of polychlorinated dibenzo-p-dioxins, furans and dioxin-like polychlorinated biphenyls.

    Science.gov (United States)

    García-Bermejo, Ángel; Ábalos, Manuela; Sauló, Jordi; Abad, Esteban; González, María José; Gómara, Belén

    2015-08-19

    This paper reports on the optimisation, characterisation, validation and applicability of gas chromatography coupled to triple quadrupole mass spectrometry in its tandem operation mode (GC-QqQ(MS/MS) for the quantification of polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs, dioxins) and dioxin-like polychlorinated biphenyls (DL-PCBs) in environmental and food matrices. MS/MS parameters were selected to achieve the high sensitivity and selectivity required for the analysis of this type of compounds and samples. Good repeatability for areas (RSD = 1-10%, for PCDD/Fs and DL-PCBs) and for ion transition ratios (RSD = 0.3-10%, for PCDD/Fs, and 0.2-15%, for DL-PCBs) and low instrumental limits of detection, 0.07-0.75 pg μL(-1) (for dioxins) and 0.05-0.63 pg μL(-1) (for DL-PCBs), were obtained. A comparative study of the congener specific determination using both GC-QqQ(MS/MS) and gas chromatography-high resolution mass spectrometry (GC-HRMS) was also performed by analysing several fortified samples and certified reference materials (CRMs) with low (feed and foodstuffs), median (sewage sludge) and high (fly ash) toxic equivalency (TEQ) concentration levels, i.e. 0.60, 1.83, 72.9 and 3609 pg WHO-TEQ(PCDD/Fs) g(-1). The agreement between the results obtained for the total TEQs (dioxins) on GC-QqQ(MS/MS) and GC-HRMS in all the investigated samples were within the range of ±4%, and that of DL-PCBs at concentration levels of 0.84 pg WHO-TEQs (DL-PCBs) g(-1), in the case of feedstuffs, was 0.11%. Both instrumental methods have similar and comparable linearity, precision and accuracy. The GC-QqQ(MS/MS) sensitivity, lower than that of GC-HRMS, is good enough (iLODs in the down to low pg levels) to detect the normal concentrations of these compounds in food and environmental samples. These results make GC-QqQ(MS/MS) suitable for the quantitative analysis of dioxins and DL-PCBs and a real alternative tool to the reference sector HRMS instruments. Copyright © 2015 Elsevier

  4. Cu nuclear quadrupole resonance study of La sub 2 sub - sub x Sr sub x Cu sub 1 sub - sub y Zn sub y O sub 4 (x=0.10, 0.15 and 0.20). Zn-induced wipeout effect near the magnetic and electric instability

    CERN Document Server

    Yamagata, H; Nakamura, K; Matsumura, M; Itoh, Y

    2003-01-01

    We studied Zn-substitution effect on the high-T sub c superconductors, underdoped La sub 2 sub - sub x Sr sub x Cu sub 1 sub - sub y Zn sub y O sub 4 (x=0.10; y=0, 0.01, 0.02), optimally doped (x=0.15; y=0, 0.02), and overdoped (x=0.20; y=0, 0.03, 0.06) in a temperature range of T=4.2-300 K, using Cu nuclear quadrupole resonance (NQR) spin-echo technique. We found full disappearance of the Cu NQR signals for the Zn-substituted, Sr-underdoped x=0.10 samples below about 40 K, partial disappearance for the Sr-optimally doped ones below about 50 K, but not for the overdoped x=0.20 ones. From the Zn-doping, the Sr-doping and the temperature dependence of the wipeout effect, we associate the wipeout effect with Zn-induced Curie magnetism or its extended glassy charge-spin stripe formation. (author)

  5. General quadrupole nuclear shapes. An algebraic perspective

    Energy Technology Data Exchange (ETDEWEB)

    Leviatan, A. (Los Alamos National Lab. (LANL), NM (USA). Theoretical Div.); Shao Bin (Yale Univ., New Haven, CT (USA). Sloane Physics Lab.)

    1990-07-05

    Spherical, axial and non-axial quadrupole shapes are investigated within the algebraic interacting boson model. For each shape the hamiltonian is resolved into intrinsic and collective parts, normal modes are identified and intrinsic states are constructed. Special emphasis is paid to new features (e.g. rigid triaxiality and coexisting deformed shapes) that emerge in the presence of three-body interactions. (orig.).

  6. Closed orbit response to quadrupole strength variation

    Energy Technology Data Exchange (ETDEWEB)

    Wolski, Andrzej; Zimmermann, Frank

    2004-01-20

    We derive two formulae relating the variation in closed orbit in a storage ring to variations in quadrupole strength, neglecting nonlinear and dispersive effects. These formulae correct results previously reported [1,2,3]. We compare the results of the formulae applied to the ATF with simulations using MAD, and consider their application to beam-based alignment.

  7. Quench performance and mechanical behavior of the first Fermilab- built prototype high gradient quadrupole for the LHC interaction regions

    CERN Document Server

    Andreev, N; Bauer, P; Bossert, R; Brandt, J; Carson, J; Caspi, S; Chichili, D R; Di Marco, J; Fehér, S; Ghosh, A; Glass, H; Kerby, J S; Lamm, M J; Makarov, A; McInturff, A D; Nicol, T H; Nobrega, A; Novitski, I; Orris, D; Peterson, T; Rabehl, Roger Jon; Robotham, W; Scanlan, R M; Schlabach, P; Sylvester, C D; Strait, J B; Tartaglia, A; Tompkins, J C; Velev, G V; Yadav, S; Zlobin, A V

    2002-01-01

    As part of the US LHC program to provide high gradient superconducting quadrupoles for the LHC interaction regions, a 5.5 meter long prototype magnet has been built and tested horizontally in a production type cryostat at Fermilab. This prototype magnet was used to validate the mechanical and magnetic design, production fabrication and assembly tooling. The first prototype magnet has met the LHC requirements of operating at 215 T/m with excellent magnetic field harmonics. This paper summarizes the test results of this magnet, including quench tests and mechanical behavior over several thermal cycles. (11 refs).

  8. Laser-induced quadrupole-quadrupole collisional energy transfer in Xe-Kr

    Institute of Scientific and Technical Information of China (English)

    Lu Zhen-Zhong; Chen De-Ying; Fan Rong-Wei; Xia Yuan-Qin

    2011-01-01

    By considering the relative velocity distribution function and multipole expansion interaction Hamiltonian, a three-state model for calculating the cross section of laser-induced quadrupole-quadrupole collisional energy transfer is presented. Calculated results in Xe-Kr system show that in the present system, the laser-induced collision process occurs for ~4 ps, which is much shorter than the dipole-dipole laser-induced collisional energy transfer (LICET) process.The spectrum of laser-induced quadrupole-quadrupole collisional energy transfer in Xe-Kr system has wider tunable range in an order of magnitude than the dipole-dipole LICET spectra. The peak cross section decreases and moves to the quasi-static wing with increasing temperature and the full width at half peak of the profile becomes larger as the system temperature increases.

  9. Coil Creep and Skew-Quadrupole Field Components in the Tevatron

    Energy Technology Data Exchange (ETDEWEB)

    Annala, G.; Harding, D.J.; Syphers, M.J.; /Fermilab

    2011-07-11

    During the start-up of Run II of the Tevatron Collider program, several issues surfaced which were not present, or not seen as detrimental, during Run I. These included the repeated deterioration of the closed orbit requiring orbit smoothing every two weeks or so, the inability to correct the closed orbit to desired positions due to various correctors running at maximum limits, regions of systematically strong vertical dipole corrections, and the identification of very strong coupling between the two transverse degrees-of-freedom. It became apparent that many of the problems being experienced operationally were connected to a deterioration of the main dipole magnet alignment, and remedial actions were undertaken. However, the alignment alone was not enough to explain the corrector strengths required to handle transverse coupling. With one exception, strong coupling had generally not been an issue in the Tevatron during Run I. Based on experience with the Main Ring, the Tevatron was designed with a very strong skew quadrupole circuit to compensate any quadrupole alignment and skew quadrupole field errors that might present themselves. The circuit was composed of 48 correctors placed evenly throughout the arcs, 8 per sector, evenly placed in every other cell. Other smaller circuits were installed but not initially needed or commissioned. These smaller circuits were composed of individual skew quadrupole correctors on either side of the long straight sections. These circuits were tuned by first bringing the horizontal and vertical tunes near each other. The skew quadrupoles were then adjusted to minimize tune split, usually to less than 0.003. Initially, the main skew quad circuit (designated T:SQ) could accomplish this global decoupling with only 4% of its possible current, and the smaller circuits were not required at all. The start-up of Run Ib was complicated by what was later discovered to be a rolled triplet quadrupole magnet in one of the Interaction Regions

  10. Accelerator and Technical Sector Seminar: Mechanical stabilization and positioning of CLIC quadrupoles with sub-nanometre resolution

    CERN Multimedia

    2011-01-01

    Thursday 24 November 2010 Accelerator and Technical Sector Seminar at 14:15  -  BE Auditorium, bldg. 6 (Meyrin) – please note unusual place Mechanical stabilization and positioning of CLIC quadrupoles with sub-nanometre resolution Stef Janssens /EN-MME Abstract: To reach the required luminosity at the CLIC interaction point, about 4000 quadrupoles are needed to obtain a vertical beam size of 1 nm at the interaction point. The mechanical jitter of the quadrupole magnets will result in an emittance growth. An active vibration isolation system is required to reduce vibrations from the ground and from external forces to about 1.5 nm integrated root mean square (r.m.s.) vertical displacement at 1 Hz. A short overview of vibration damping and isolation strategies will be presented as well as a comparison of existing systems. The unprecedented resolution requirements and the instruments enabling these measurements will be discussed. The vibration sources from which the magnets need to...

  11. Confining rigid balls by mimicking quadrupole ion trapping

    CERN Document Server

    Fan, Wenkai; Wang, Sihui; Zhou, Huijun

    2016-01-01

    The rotating saddle not only is an interesting system that is able to trap a ball near its saddle point, but can also intuitively illustrate the operating principles of quadrupole ion traps in modern physics. Unlike the conventional models based on the mass-point approximation, we study the stability of a ball in a rotating-saddle trap using rigid-body dynamics. The stabilization condition of the system is theoretically derived and subsequently verified by experiments. The results are compared with the previous mass-point model, giving large discrepancy as the curvature of the ball is comparable to that of the saddle. We also point out that the spin angular velocity of the ball is analogous to the cyclotron frequency of ions in an external magnetic field utilized in many prevailing ion-trapping schemes.

  12. Sorting and Selection in Posets

    CERN Document Server

    Daskalakis, Constantinos; Mossel, Elchanan; Riesenfeld, Samantha; Verbin, Elad

    2007-01-01

    Classical problems of sorting and searching assume an underlying linear ordering of the objects being compared. In this paper, we study a more general setting, in which some pairs of objects are incomparable. This generalization is relevant in applications related to rankings in sports, college admissions, or conference submissions. It also has potential applications in biology, such as comparing the evolutionary fitness of different strains of bacteria, or understanding input-output relations among a set of metabolic reactions or the causal influences among a set of interacting genes or proteins. Our results improve and extend results from two decades ago of Faigle and Tur\\'{a}n. A measure of complexity of a partially ordered set (poset) is its width. Our algorithms obtain information about a poset by queries that compare two elements. We present an algorithm that sorts, i.e. completely identifies, a width w poset of size n and has query complexity O(wn + nlog(n)), which is within a constant factor of the in...

  13. Tunable Superomniphobic Surfaces for Sorting Droplets by Surface Tension

    Science.gov (United States)

    Movafaghi, Sanli; Wang, Wei; Metzger, Ari; Williams, Desiree; Williams, John; Kota, Arun

    2016-11-01

    Manipulation of liquid droplets on super-repellent surfaces (i.e., surfaces that are extremely repellent to liquids) has been widely studied because droplets exhibit high mobility on these surfaces due to the ultra-low adhesion, which leads to minimal sample loss and contamination. Although droplet manipulation has been demonstrated using electric fields, magnetic fields, guiding tracks and wettability gradients, to the best of our knowledge, there are no reports of droplet manipulation methods that can sort droplets by surface tension on super-repellent surfaces. In this work, we utilized tunable superomniphobic surfaces (i.e., surfaces that are extremely repellent to virtually all liquids) to develop a simple device with precisely tailored solid surface energy domains that, for the first time, can sort droplets by surface tension. Droplet sorting occurs on our device entirely due to a balance between the work done by gravity and the work expended due to adhesion, without the need for any external energy input. Our device can be fabricated easily in a short time and is particularly useful for in-the-field and on-the-go operations, where complex analysis equipment is unavailable. We envision that our methodology for droplet sorting will enable inexpensive and energy-efficient analytical devices for personalized point-of-care diagnostic platforms and lab-on-a-chip systems.

  14. A "cool" set of magnets

    CERN Multimedia

    2003-01-01

    The first Short Straight Section for the LHC arcs, containing the first Main Quadrupole and two packages of corrector magnets, was fully assembled and successfully cold tested at CERN end of September.

  15. Fixing the Sorting Algorithm for Android, Java and Python

    NARCIS (Netherlands)

    C.P.T. de Gouw (Stijn); F.S. de Boer (Frank)

    2015-01-01

    htmlabstractTim Peters developed the Timsort hybrid sorting algorithm in 2002. TimSort was first developed for Python, a popular programming language, but later ported to Java (where it appears as java.util.Collections.sort and java.util.Arrays.sort). TimSort is today used as the default sorting alg

  16. Fixing the Sorting Algorithm for Android, Java and Python

    NARCIS (Netherlands)

    Gouw, C.P.T. de; Boer, F.S. de

    2015-01-01

    Tim Peters developed the Timsort hybrid sorting algorithm in 2002. TimSort was first developed for Python, a popular programming language, but later ported to Java (where it appears as java.util.Collections.sort and java.util.Arrays.sort). TimSort is today used as the default sorting algorithm in Ja

  17. Fixing the Sorting Algorithm for Android, Java and Python

    NARCIS (Netherlands)

    C.P.T. de Gouw (Stijn); F.S. de Boer (Frank)

    2015-01-01

    htmlabstractTim Peters developed the Timsort hybrid sorting algorithm in 2002. TimSort was first developed for Python, a popular programming language, but later ported to Java (where it appears as java.util.Collections.sort and java.util.Arrays.sort). TimSort is today used as the default sorting

  18. Energy efficient data sorting using standard sorting algorithms

    KAUST Repository

    Bunse, Christian

    2011-01-01

    Protecting the environment by saving energy and thus reducing carbon dioxide emissions is one of todays hottest and most challenging topics. Although the perspective for reducing energy consumption, from ecological and business perspectives is clear, from a technological point of view, the realization especially for mobile systems still falls behind expectations. Novel strategies that allow (software) systems to dynamically adapt themselves at runtime can be effectively used to reduce energy consumption. This paper presents a case study that examines the impact of using an energy management component that dynamically selects and applies the "optimal" sorting algorithm, from an energy perspective, during multi-party mobile communication. Interestingly, the results indicate that algorithmic performance is not key and that dynamically switching algorithms at runtime does have a significant impact on energy consumption. © Springer-Verlag Berlin Heidelberg 2011.

  19. Coil End Optimization of the Nb$_3$Sn Quadrupole for the High Luminosity LHC

    CERN Document Server

    Izquierdo Bermudez, S; Bossert, R; Cheng, D; Ferracin, P; Krave, ST; Perez, J C; Schmalzle, J; Yu, M

    2015-01-01

    As part of the Large Hadron Collider Luminosity upgrade (HiLumi-LHC) program, the US LARP collaboration and CERN are working together to design and build a 150 mm aperture quadrupole magnet that aims at providing a nominal gradient of 140 T/m. The resulting conductor peak field of more than 12 T requires the use of Nb3Sn superconducting coils. In this paper the coil design for the quadrupole short model (SQXF) is described, focusing in particular on the optimization of the end-parts. We first describe the magnetic optimization aiming at reducing the peak field enhancement in the ends and minimizing the integrated multipole content. Then we focus on the analysis and tests performed to determine the most suitable shapes of end turns and spacers, minimizing the mechanical stress on the cables. We conclude with a detailed description of the baseline end design for the first series of the short model coils.

  20. Status of a study of stabilization and fine positioning of CLIC quadrupoles to the nanometre level

    CERN Document Server

    Artoos, K; Esposito, M; Fernandez Carmona, P; Guinchard, M; Hauviller, C; Janssens, S; Kuzmin, A; Leuxe, R; Moron Ballester, R

    2011-01-01

    Mechanical stability to the nanometre and below is required for the Compact Linear Collider (CLIC) quadrupoles to frequencies as low as 1 Hz. An active stabilization and positioning system based on very stiff piezo electric actuators and inertial reference masses is under study for the Main Beam Quadrupoles (MBQ). The stiff support was selected for robustness against direct forces and for the option of incrementally repositioning the magnet with nanometre resolution. The technical feasibility was demonstrated by a representative test mass being stabilized and repositioned to the required level in the vertical and lateral direction. Technical issues were identified and the development programme of the support, sensors, and controller was continued to increase the performance, integrate the system in the overall controller, adapt to the accelerator environment, and reduce costs. The improvements are implemented in models, test benches, and design of the first stabilized prototype CLIC magnet. The characterizati...

  1. Measurements of electric quadrupole moments of neutron-deficient Au, Pt, and Ir nuclei with NMR-ON in hcp-Co

    CERN Multimedia

    Smolic, E; Hagn, E; Zech, E; Seewald, G

    2002-01-01

    The aim of the experiments is the measurement of $\\,$i) nuclear magnetic moments and electric quadrupole moments of neutron-deficient isotopes in the region Os-Ir-Pt-Au with the methods of quadrupole-interaction-resolved NMR on oriented nuclei " QI-NMR-ON " and modulated adiabatic passage on oriented nuclei " MAPON " and $\\,$ii) the magnetic hyperfine field, electric field gradient (EFG), and spin-lattice relaxation of 5d elements in ferromagnetic Fe, Ni, fcc-Co and hcp-Co.\\\\ The measurements on Au isotopes have been finished successfully. The quadrupole moments of $^{186}$Au, $^{193m}$Au, $^{195}$Au, $^{195m}$Au, $^{197m}$Au, $^{198}$Au and $^{199}$Au were determined with high precision.\\\\ For neutron-deficient Ir isotopes QI-NMR-ON measurements were performed after implantation of Hg precursors. The EFG of Ir in hcp-Co has been calibrated. Thus precise values for the spectroscopic quadrupole mo...

  2. Focusing magnets for HIF based on racetracks

    Energy Technology Data Exchange (ETDEWEB)

    Martovetsky, N N; Manahan, R R

    2000-09-11

    Heavy Ion Fusion (HIF) is considered a promising path to a practical fusion reactor. A driver for a HIF reactor will require a large number of quadrupole arrays to focus heavy ion beams. A conceptual design, and trade off studies of the quadrupole array based on racetracks are presented. A comparison with a conventional shell magnet is given and advantages and disadvantages are discussed. A more detailed design of a single quadrupole for the High Current experiment (HCX) is presented and discussed.

  3. Electric quadrupole interaction in cubic BCC α-Fe

    Energy Technology Data Exchange (ETDEWEB)

    Błachowski, A.; Komędera, K. [Mössbauer Spectroscopy Division, Institute of Physics, Pedagogical University, ul. Podchorążych 2, PL-30-084 Kraków (Poland); Ruebenbauer, K., E-mail: sfrueben@cyf-kr.edu.pl [Mössbauer Spectroscopy Division, Institute of Physics, Pedagogical University, ul. Podchorążych 2, PL-30-084 Kraków (Poland); Cios, G.; Żukrowski, J. [AGH University of Science and Technology, Academic Center for Materials and Nanotechnology, Av. A. Mickiewicza 30, PL-30-059 Kraków (Poland); Górnicki, R. [RENON, ul. Gliniana 15/15, PL-30-732 Kraków (Poland)

    2016-07-15

    Mössbauer transmission spectra for the 14.41-keV resonant line in {sup 57}Fe have been collected at room temperature by using {sup 57}Co(Rh) commercial source and α-Fe strain-free single crystal as an absorber. The absorber was magnetized to saturation in the absorber plane perpendicular to the γ-ray beam axis applying small external magnetic field. Spectra were collected for various orientations of the magnetizing field, the latter lying close to the [110] crystal plane. A positive electric quadrupole coupling constant was found practically independent on the field orientation. One obtains the following value V{sub zz} = +1.61(4) × 10{sup 19} Vm{sup −2} for the (average) principal component of the electric field gradient (EFG) tensor under assumption that the EFG tensor is axially symmetric and the principal axis is aligned with the magnetic hyperfine field acting on the {sup 57}Fe nucleus. The nuclear spectroscopic electric quadrupole moment for the first excited state of the {sup 57}Fe nucleus was adopted as +0.17 b. Similar measurement was performed at room temperature using as-rolled polycrystalline α-Fe foil of high purity in the zero external field. Corresponding value for the principal component of the EFG was found as V{sub zz} = +1.92(4) × 10{sup 19} Vm{sup −2}. Hence, it seems that the origin of the EFG is primarily due to the local (atomic) electronic wave function distortion caused by the spin–orbit interaction between effective electronic spin S and incompletely quenched electronic angular momentum L. It seems as well that the lowest order term proportional to the product L·λ·S dominates, as no direction dependence of the EFG principal component is seen. The lowest order term is isotropic for a cubic symmetry as one has λ=λ 1 for cubic systems with the symbol 1 denoting unit operator and λ being the coupling parameter. - Highlights: • Precision of MS the same as MAPON • Real scans versus magnetization direction • A challenge

  4. Prototype Superconducting Quadrupole for the ISR high-luminosity (low beta)insertion:end view.

    CERN Multimedia

    1977-01-01

    In this picture, taken before the insertion of the inner vacuum chamber with inbedded 6-pole superconducting windings, one can see the main components of the magnet structure: (from inside outwards) the superconducting quadrupole coils surronded by glass epoxy bandage rings and stainless steel spacers, the low-carbon steel yoke quadrants and the aluminium alloy shrinking rings. See also photos 7702307, 7702688X, 7702690X.

  5. On the Construction of Sorted Reactive Systems

    DEFF Research Database (Denmark)

    Birkedal, Lars; Debois, Søren; Hildebrandt, Thomas

    2008-01-01

    We develop a theory of sorted bigraphical reactive systems. Every application of bigraphs in the literature has required an extension, a sorting, of pure bigraphs. In turn, every such application has required a redevelopment of the theory of pure bigraphical reactive systems for the sorting at hand...... bigraphs. Technically, we give our construction for ordinary reactive systems, then lift it to bigraphical reactive systems. As such, we give also a construction of sortings for ordinary reactive systems. This construction is an improvement over previous attempts in that it produces smaller and much more...

  6. Polarization enhanced Nuclear Quadrupole Resonance with an atomic magnetometer

    Science.gov (United States)

    Malone, Michael W.; Barrall, Geoffrey A.; Espy, Michelle A.; Monti, Mark C.; Alexson, Dimitri A.; Okamitsu, Jeffrey K.

    2016-05-01

    Nuclear Quadrupole Resonance (NQR) has been demonstrated for the detection of 14-N in explosive compounds. Application of a material specific radio-frequency (RF) pulse excites a response typically detected with a wire- wound antenna. NQR is non-contact and material specific, however fields produced by NQR are typically very weak, making demonstration of practical utility challenging. For certain materials, the NQR signal can be increased by transferring polarization from hydrogen nuclei to nitrogen nuclei using external magnetic fields. This polarization enhancement (PE) can enhance the NQR signal by an order of magnitude or more. Atomic magnetometers (AM) have been shown to improve detection sensitivity beyond a conventional antenna by a similar amount. AM sensors are immune to piezo-electric effects that hamper conventional NQR, and can be combined to form a gradiometer for effective RF noise cancellation. In principle, combining polarization enhancement with atomic magnetometer detection should yield improvement in signal-to-noise ratio that is the product of the two methods, 100-fold or more over conventional NQR. However both methods are even more exotic than traditional NQR, and have never been combined due to challenges in operating a large magnetic field and ultra-sensitive magnetic field sensor in proximity. Here we present NQR with and without PE with an atomic magnetometer, demonstrating signal enhancement greater than 20-fold for ammonium nitrate. We also demonstrate PE for PETN using a traditional coil for detection with an enhancement factor of 10. Experimental methods and future applications are discussed.

  7. Development and Coil Fabrication for the LARP 3.7-m Long Nb3Sn Quadrupole

    Energy Technology Data Exchange (ETDEWEB)

    Ambrosio, G.; Andreev, N.; Anerella, M.; Barzi, E.; Bossert, R.; Caspi, S.; Chlachidize, G.; Dietderich, D.; Felice, H.; Ferracin, P.; Ghosh, A.; Hafalia, R.; Hannaford, R.; Jochen, G.; Kashikhin, V.V.; Kovach, P.; Lamm, M.; Lietzke, A.; McInturff, A.; Muratore,, J.; Nobreaga, F.; Novitsky, I.; Peggs, S.; Prestemon, S.; Sabbi, G. L.; Schmalzle, J.; Turrioni, D.; Wanderer, P.; Whitson, G.; Zlobin, A. V.

    2008-08-17

    The U.S. LHC Accelerator Research Program (LARP) has started the fabrication of 3.7-m long Nb{sub 3}Sn quadrupole models. The Long Quadrupoles (LQ) are 'Proof-of-Principle' magnets which are to demonstrate that Nb{sub 3}Sn technology is mature for use in high energy particle accelerators. Their design is based on the LARP Technological Quadrupole (TQ) models, developed at FNAL and LBNL, which have design gradients higher than 200 T/m and an aperture of 90 mm. The plans for the LQ R&D and a design update are presented and discussed in this paper. The challenges of fabricating long accelerator-quality Nb{sub 3}Sn coils are presented together with the solutions adopted for the LQ coils (based on the TQ experience). During the fabrication and inspection of practice coils some problems were found and corrected. The fabrication at BNL and FNAL of the set of coils for the first Long Quadrupole is in progress.

  8. Production and performance of the LHC interaction region quadrupoles at KEK

    CERN Document Server

    Nakamoto, T; Fujii, T; Hashiguchi, E; Higashi, N; Hirano, H; Iida, M; Kanahara, T; Kimura, N; Murai, S; Odajima, W; Ogitsu, T; Ohhata, H; Ohuchi, N; Orikasa, T; Shintomi, T; Sugawara, S; Sugita, K; Tanaka, K; Terashima, A; Tsuchiya, K; Yamamoto, A

    2003-01-01

    The MQXA superconducting low-beta quadrupole magnets for the LHC interaction regions are required to generate a field gradient of up to 215 T/m at 1.9 K along an effective magnetic length of 6.37 m. After completion of an R&D program on short models and full length prototypes, the series production of magnets has started, with to date five series magnets subsequently tested at KEK. Basic characteristics such as normal training, subsequent full energy dump, thermal cycle, ramp rate dependence and temperature dependence have been studied and results indicate that magnets have satisfactory quench performance. Magnetic field measurements performed at 1.9 K show the field quality to be uniform and to satisfy the stringent beam optics requirements. (10 refs).

  9. Exterior and interior metrics with quadrupole moment

    CERN Document Server

    Quevedo, Hernando

    2010-01-01

    We present the Ernst potential and the line element of an exact solution of Einstein's vacuum field equations that contains as arbitrary parameters the total mass, the angular momentum, and the quadrupole moment of a rotating mass distribution. We show that in the limiting case of slowly rotating and slightly deformed configuration, there exists a coordinate transformation that relates the exact solution with the approximate Hartle solution. It is shown that this approximate solution can be smoothly matched with an interior perfect fluid solution with physically reasonable properties. This opens the possibility of considering the quadrupole moment as an additional physical degree of freedom that could be used to search for a realistic exact solution, representing both the interior and exterior gravitational field generated by a self-gravitating axisymmetric distribution of mass of perfect fluid in stationary rotation.

  10. Electrostatic quadrupole DC accelerators for BNCT applications

    Energy Technology Data Exchange (ETDEWEB)

    Kwan, J.W.; Anderson, O.A.; Reginato, L.L.; Vella, M.C.; Yu, S.S.

    1994-04-01

    A dc electrostatic quadrupole (ESQ) accelerator is capable of producing a 2.5 MeV, 100 mA proton beam for the purpose of generating neutrons for Boron Neutron Capture Therapy. The ESQ accelerator is better than the conventional aperture column in high beam current application due to the presence of stronger transverse field for beam focusing and for suppressing secondary electrons. The major challenge in this type of accelerator is in developing the proper power supply system.

  11. TOUTATIS: A radio frequency quadrupole code

    OpenAIRE

    Romuald Duperrier

    2000-01-01

    A cw high power linear accelerator can only work with very low particle losses and structure activation. At low energy, the radio frequency quadrupole (RFQ) is an accelerator element that is very sensitive to losses. To design this structure, a good understanding of the beam dynamics is required. Generally, the reference code PARMTEQM is enough to design the accelerator. TOUTATIS has been written with the goals of cross-checking results and obtaining more reliable dynamics. This paper relates...

  12. Design and realization of sort manipulator of crystal-angle sort machine

    Science.gov (United States)

    Wang, Ming-shun; Chen, Shu-ping; Guan, Shou-ping; Zhang, Yao-wei

    2005-12-01

    It is a current tendency of development in automation technology to replace manpower with manipulators in working places where dangerous, harmful, heavy or repetitive work is involved. The sort manipulator is installed in a crystal-angle sort machine to take the place of manpower, and engaged in unloading and sorting work. It is the outcome of combing together mechanism, electric transmission, and pneumatic element and micro-controller control. The step motor makes the sort manipulator operate precisely. The pneumatic elements make the sort manipulator be cleverer. Micro-controller's software bestows some simple artificial intelligence on the sort manipulator, so that it can precisely repeat its unloading and sorting work. The combination of manipulator's zero position and step motor counting control puts an end to accumulating error in long time operation. A sort manipulator's design in the practice engineering has been proved to be correct and reliable.

  13. CLIC quadrupole stabilization and nano-positioning

    CERN Document Server

    Collette, C; Artoos, K; Fernandez Carmona, P; Guinchard, M; Hauviller, C

    2010-01-01

    In the Compact LInear Collider (CLIC) currently under study, electrons and positrons will be accelerated in two linear accelerators to collide at the interaction point with an energy of 0.5- 3 TeV. This machine is constituted of a succession of accelerating structures, used to accelerate the beams of particles, and electromagnets (quadrupoles) used to focus the beams. In order to ensure good performances, the quadrupoles have to be extremely stable. Additionally, they should also have the capability to move by steps of some tens of nanometers every 20 ms with a precision of +/- 1nm. This paper proposes a holistic approach to fulfill alternatively both requirements using the same device. The concept is based on piezoelectric hard mounts to isolate the quadrupoles from the ground vibrations in the sensitive range between 1 and 20 Hz, and to provide nano-positioning capabilities. It is also shown that this strategy ensures robustness to external forces (acoustic noise, water flow for the cooling, air flow for th...

  14. Table of nuclear electric quadrupole moments

    Science.gov (United States)

    Stone, N. J.

    2016-09-01

    This Table is a compilation of experimental measurements of static electric quadrupole moments of ground states and excited states of atomic nuclei throughout the periodic table. To aid identification of the states, their excitation energy, half-life, spin and parity are given, along with a brief indication of the method and any reference standard used in the particular measurement. Experimental data from all quadrupole moment measurements actually provide a value of the product of the moment and the electric field gradient [EFG] acting at the nucleus. Knowledge of the EFG is thus necessary to extract the quadrupole moment. A single recommended moment value is given for each state, based, for each element, wherever possible, upon a standard reference moment for a nuclear state of that element studied in a situation in which the electric field gradient has been well calculated. For several elements one or more subsidiary EFG/moment reference is required and their use is specified. The literature search covers the period to mid-2015.

  15. Contribution of electric quadrupole and dipole-quadrupole interference terms in Coulomb breakup of 15C

    Science.gov (United States)

    Singh, P.; Kharb, S.; Singh, M.

    2014-02-01

    The effects of electric quadrupole ( E2) and dipole-quadrupole interference ( E1- E2) terms in the Coulomb breakup of 15C have been investigated within the framework of eikonal approximation. The sensitivity of Coulomb breakup cross section, differential in relative energy and Longitudinal Momentum Distribution (LMD) of core fragments, towards these terms have been examined. A very small (1% of E1) contribution of E2 transition has been predicted in integrated Coulomb breakup cross section. Further it is also found that the inclusion of E2 and E1- E2 terms introduces a small asymmetry in the peak of relative energy spectrum and also increases the peak height of the spectrum. The contribution of dipole-quadrupole interference terms is clearly shown in LMD, as it introduces an asymmetry in the shape of LMD and enhances the matching between the data and predictions.

  16. Fast switching NMR system for measurements of ground-state quadrupole moments of short-lived nuclei

    CERN Document Server

    Minamisono, K; Crawford, H L; Mantica, P F; Matsuta, K; Minamisono, T; Pinter, J S; Stoker, J B

    2008-01-01

    A beta-ray detecting nuclear quadrupole resonance system has been developed at NSCL/MSU to measure ground-state electric quadrupole moments of short-lived nuclei produced as fast rare isotope beams. This system enables quick and sequential application of multiple transition frequencies over a wide range. Fast switching between variable capacitors in resonance circuits ensures sufficient power delivery to the coil in the beta-ray detecting nuclear magnetic resonance technique. The fast switching technique enhances detection efficiency of resonance signals and is especially useful when the polarization and/or production rate of the nucleus of interest are small and when the nuclear spin is large.

  17. Data parallel sorting for particle simulation

    Science.gov (United States)

    Dagum, Leonardo

    1992-01-01

    Sorting on a parallel architecture is a communications intensive event which can incur a high penalty in applications where it is required. In the case of particle simulation, only integer sorting is necessary, and sequential implementations easily attain the minimum performance bound of O (N) for N particles. Parallel implementations, however, have to cope with the parallel sorting problem which, in addition to incurring a heavy communications cost, can make the minimun performance bound difficult to attain. This paper demonstrates how the sorting problem in a particle simulation can be reduced to a merging problem, and describes an efficient data parallel algorithm to solve this merging problem in a particle simulation. The new algorithm is shown to be optimal under conditions usual for particle simulation, and its fieldwise implementation on the Connection Machine is analyzed in detail. The new algorithm is about four times faster than a fieldwise implementation of radix sort on the Connection Machine.

  18. Scalable, Multithreaded, Partially-in-Place Sorting

    Energy Technology Data Exchange (ETDEWEB)

    Haglin, David J.; Adolf, Robert D.; Mackey, Greg E.

    2013-05-20

    A recent trend in hardware development is producing computing systems that are stretching the number of cores and size of shared-memory beyond where most fundamental serial algorithms perform well. The expectation is that this trend will continue. So it makes sense to rethink our fundamental algorithms such as sorting. There are many situations where data that needs to be sorted will actually fit into the shared memory so applications could benefit from an efficient parallel sorting algorithm. When sorting large data (at least hundreds of Gigabytes) in a single shared memory, there are two factors that affect the algorithm choice. First, does the algorithm sort in-place? And second, does the algorithm scale well beyond tens of threads? Surprisingly, existing algorithms posses either one of these factors, but not both. We present an approach that gracefully degrades in performance as the amount of available working memory decreases relative to the size of the input.

  19. Data Sorting Using Graphics Processing Units

    Directory of Open Access Journals (Sweden)

    M. J. Mišić

    2012-06-01

    Full Text Available Graphics processing units (GPUs have been increasingly used for general-purpose computation in recent years. The GPU accelerated applications are found in both scientific and commercial domains. Sorting is considered as one of the very important operations in many applications, so its efficient implementation is essential for the overall application performance. This paper represents an effort to analyze and evaluate the implementations of the representative sorting algorithms on the graphics processing units. Three sorting algorithms (Quicksort, Merge sort, and Radix sort were evaluated on the Compute Unified Device Architecture (CUDA platform that is used to execute applications on NVIDIA graphics processing units. Algorithms were tested and evaluated using an automated test environment with input datasets of different characteristics. Finally, the results of this analysis are briefly discussed.

  20. Sorting carbon nanotubes for electronics.

    Science.gov (United States)

    Martel, Richard

    2008-11-25

    Because of their unique structure and composition, single-wall carbon nanotubes (SWNTs) are at the interface between molecules and crystalline solids. They also present properties that are ideal for making lightweight, inexpensive, and flexible electronics. The raw material is composed of a heterogeneous mixture of SWNTs that differ in helicity and diameter and, therefore, requires purification and separation. In a series of groundbreaking experiments, a robust process serving this purpose was developed based on SWNTs encapsulated in surfactants and water. Ultracentrifugation in a density gradient combined with surfactant mixtures provided buoyant density differences, enabling enrichment for both diameter and electronic properties. A new paper in this issue explores further the process through the hydrodynamic properties of SWNT-surfactant complexes. The study reveals that we have just begun to uncover the dynamics and properties of nanotube-surfactant interactions and highlights the potential that could be gained from a better understanding of their chemistry. The time scale of integration of carbon nanotubes into electronics applications remains unclear, but the recent developments in sorting out SWNTs paves the way for improving on the properties of network-based SWNTs.

  1. An MDM Spin Transparent Quadrupole for Storage Ring based EDM Search

    CERN Document Server

    Bai, Mei; Sagan, David

    2016-01-01

    A storage ring provides an attractive option for directly measuring the electric dipole moment~(EDM) of charged particles. To reach a sensitivity of 10^-29 e x cm, it is critical to mitigate the systematic errors from all sources. This daunting task is pushing the precision frontier of accelerator science and technology beyond its current state of the art. Here, we present a unique idea of a magnetic dipole moment~(MDM) spin transparent quadrupole that can significantly reduce the systematic errors due to the transverse electric and magnetic fields that particle encounters.

  2. THE EFFECT OF OCCURRENCE CHARACTERISTICS OF MAGNETIC MINERALS IN SLAG ON SORTING PERFORMANCE%钢渣中磁性矿物的赋存特性对分选效果的影响研究

    Institute of Scientific and Technical Information of China (English)

    范永平; 王申; 王延兵

    2012-01-01

    对新余钢铁公司0~10 mm的细粒钢渣干式磁选分离所得到的产品进行扫描电镜检测、分析,找出了影响细粒钢渣干式磁选指标难以得到提高的原因,用于指导生产实践。研究结果表明:钢渣在干式磁选过程中,包裹有微细粒的金属铁或与金属铁连生的浮氏体以及具有一定磁性的铁酸盐容易进入磁性分离物中,这些物质自身铁品位较低,从而造成了磁性分离物中铁品位的降低。%It is detected and analyzed the product of fine-grain steel slag of 0~10 mm from Xinyu Iron and Steel Plant by dry magnetic separation,using scanning electron microscopy,with which the reason why the dry magnetic separation indexes of this slag are difficult to improve,which may give a guidance to production.The results show that in the dry separation process of the slag,the floating body encased with micro-fine metal iron or the one produced with metal iron and the magnetic ferrite can easily access to the magnetic separation,whose iron grade is lower than iron,resulting in the magnetic separation's iron grade reduce.

  3. Enhancement of Selection, Bubble and Insertion Sorting Algorithm

    Directory of Open Access Journals (Sweden)

    Muhammad Farooq Umar

    2014-07-01

    Full Text Available In everyday life there is a large amount of data to arrange because sorting removes any ambiguities and make the data analysis and data processing very easy, efficient and provides with cost less effort. In this study a set of improved sorting algorithms are proposed which gives better performance and design idea. In this study five new sorting algorithms (Bi-directional Selection Sort, Bi-directional bubble sort, MIDBiDirectional Selection Sort, MIDBidirectional bubble sort and linear insertion sort are presented. Bi-directional Selection Sort and MIDBiDirectional Selection Sort are the enhancement on basic selection sort while Bidirectional bubble sort and MIDBidirectional bubble sort are the enhancement on basic bubble sort by changing the selection and swapping mechanism of data for sorting. Enhanced sorting algorithms reduced the iteration by half and quarter times respectively. Asymptotically complexities of these algorithms are reduced to O (n2/2 and O (n2/4 from O (n2. Linear insertion sort is the enhancement of insertion sort by changing the design of algorithm (convert two loops to one loop. So asymptotically this algorithm is converted to linear time complexity from quadratic complexity. These sorting algorithms are described using C. The proposed algorithms are analyzed using asymptotic analysis and also using machine-running time and compared with their basic sorting algorithms. In this study we also discuss how the performance and complexity can be improved by optimizing the code and design.

  4. Nuclear electric quadrupole interactions in liquids entrapped in cavities

    Energy Technology Data Exchange (ETDEWEB)

    Furman, Gregory B., E-mail: gregoryf@bgu.ac.il; Meerovich, Victor M.; Sokolovsky, Vladimir L. [Ben Gurion University of the Negev, Physics Department (Israel)

    2016-12-15

    Liquids entrapped in cavities and containing quadrupole nuclei are considered. The interaction of the quadrupole moment of a nucleus with the electric field gradient is studied. In such a system, molecules are in both rotational and translational Brownian motions which are described by the diffusion equation. Solving this equation, we show that the intra- and intermolecular nuclear quadrupole interactions are averaged to zero in cavities with the size larger than several angstroms.

  5. Test and Simulation Results for Quenches Induced by Fast Losses on a LHC Quadrupole

    CERN Document Server

    Bracco, Ch; Bartmann, W; Bednarek, M; Lechner, A; Sapinski, M; Vittal Shetty, N; Schmidt, R; Solfaroli Camillocci, M; Verweij, A

    2014-01-01

    A test program for beam induced quenches was started in the LHC in 2011 in order to reduce as much as possible BLM-triggered beam dumps, without jeopardising the safety of the superconducting magnets. A first measurement was performed to asses the quench level of a quadrupole located in the LHC injection region in case of fast (ns) losses. It consisted in dumping single bunches onto an injection protection collimator located right upstream of the quadrupole, varying the bunch intensity up to 3×1010 protons and ramping the quadrupole current up to 2200 A. No quench was recorded at that time. The test was repeated in 2013 with increased bunch intensity (6.5×1010 protons); a quench occurred when powering the magnet at 2500 A. The comparison between measurements during beam induced and quench heaters induced quenches is shown. Results of FLUKA simulations on energy deposition, calculations on quench behaviour using the QP3 code and the respective estimates of quench levels are also presented.

  6. Test Results of the first 3.7 m Long Nb3Sn Quadrupole by LARP and Future Plans

    Energy Technology Data Exchange (ETDEWEB)

    Ambrosio, G.; Andreev, N.; Anerella, M.; Barzi, E.; Bingham, B.; Bocian, D.; Bossert, R.; Caspi, S.; Chlachidize, G.; Dietderich, D.; Escallier, J.; Felice, H.; Ferracin, P.; Ghosh, A.; Godeke, A.; Hafalia, R.; Hannaford, R.; Jochen, G.; Kashikhin, V. V.; Kim, M. J.; Kovach,, P.; Lamm, M.; McInturff, A.; Muratore, J.; Nobrega, F.; Novitsky, I.; Orris, D.; Prebys, E.; Prestemon, S.; Sabbi, G. L.; Schmalzle, J.; Sylvester, C.; Tartaglia, M.; Turrioni, D.; Velev, G.; Wanderer, P.; Whitson, G.; Zlobin, A. V.

    2010-08-01

    In December 2009 during its first cold test, LQS01, the first long Nb{sub 3}Sn Quadrupole made by LARP (LHC Accelerator Research Program, a collaboration of BNL, FNAL, LBNL and SLAC), reached its target field gradient of 200 T/m. This target was set in 2005 by the US Department fo Energy, CERN and LARP, as a significant milestone toward the development of Nb{sub 3}Sn quadrupoles for possible use in LHC luminosity upgrades. LQS01 is a 90 mm aperture, 3.7 m long quadrupole using Nb{sub 3}Sn coils. The coil layout is equal to the layout used in the LARP Technological Quadrupoles (TQC and TQS models). Pre-stress and support are provided by a segmented aluminum shell pre-loaded using bladders and keys, similarly to the TQS models. After the first test the magnet was disassembled, reassembled with an optimized pre-stress, and reached 222 T/m at 4.5 K. In this paper we present the results of both tests and the next steps of the Long Quadrupole R&D.

  7. Test Results of the First 3.7 m Long Nb3Sn Quadrupole by LARP and Future Plans

    Energy Technology Data Exchange (ETDEWEB)

    Ambrosio, G.; Schmalzle, J.; Andreev, N.; Anerella, M.; Barzi, E.; Bingham, B.; Bocian, D.; Bossert, R.; Caspi, S.; Chlachidize, G.; Dietderich, D.; Escallier, J.; Felice, H.; Ferracin, P.; Ghosh, A.; Godeke, A.; Hafalia, R.; Hannaford, R.; Jochen, G.; Kashikhin, V.V.; Kim, M.J.; Kovach, P.; Lam, M.; McInturff, A.; Muratore, J.; Nobrega, F.; Novitshy, I.; Orris, D.; Prebys, E.; Prestemon, S.; Sabbi, G.L.; Schmalzle, J.; Sylvester, C.; Tartaglia, M.; Turrioni, D.; Velev, G.; Wanderer, P.; Whitson, G.; Zlobin, A.V.

    2011-08-03

    In December 2009 during its first cold test, LQS01, the first Long Nb{sub 3}Sn Quadrupole made by LARP (LHC Accelerator Research Program, a collaboration of BNL, FNAL, LBNL and SLAC), reached its target field gradient of 200 T/m. This target was set in 2005 by the US Department of Energy, CERN and LARP, as a significant milestone toward the development of Nb{sub 3}Sn quadrupoles for possible use in LHC luminosity upgrades. LQS01 is a 90 mm aperture, 3.7 m long quadrupole using Nb{sub 3}Sn coils. The coil layout is equal to the layout used in the LARP Technological Quadrupoles (TQC and TQS models). Pre-stress and support are provided by a segmented aluminum shell pre-loaded using bladders and keys, similarly to the TQS models. After the first test the magnet was disassembled, reassembled with an optimized pre-stress, and reached 222 T/m at 4.5 K. In this paper we present the results of both tests and the next steps of the Long Quadrupole R and D.

  8. An Unsupervised Online Spike-Sorting Framework.

    Science.gov (United States)

    Knieling, Simeon; Sridharan, Kousik S; Belardinelli, Paolo; Naros, Georgios; Weiss, Daniel; Mormann, Florian; Gharabaghi, Alireza

    2016-08-01

    Extracellular neuronal microelectrode recordings can include action potentials from multiple neurons. To separate spikes from different neurons, they can be sorted according to their shape, a procedure referred to as spike-sorting. Several algorithms have been reported to solve this task. However, when clustering outcomes are unsatisfactory, most of them are difficult to adjust to achieve the desired results. We present an online spike-sorting framework that uses feature normalization and weighting to maximize the distinctiveness between different spike shapes. Furthermore, multiple criteria are applied to either facilitate or prevent cluster fusion, thereby enabling experimenters to fine-tune the sorting process. We compare our method to established unsupervised offline (Wave_Clus (WC)) and online (OSort (OS)) algorithms by examining their performance in sorting various test datasets using two different scoring systems (AMI and the Adamos metric). Furthermore, we evaluate sorting capabilities on intra-operative recordings using established quality metrics. Compared to WC and OS, our algorithm achieved comparable or higher scores on average and produced more convincing sorting results for intra-operative datasets. Thus, the presented framework is suitable for both online and offline analysis and could substantially improve the quality of microelectrode-based data evaluation for research and clinical application.

  9. Distinguishing the nonjet azimuth quadrupole from QCD jets and hydrodynamic flows via 2D angular correlations and quadrupole spectrum analysis

    CERN Document Server

    Trainor, Thomas A

    2016-01-01

    According to the flow narrative commonly applied to high-energy nuclear collisions a 1D cylindrical-quadrupole component of 2D angular correlations conventionally denoted by quantity $v_2$ is interpreted to represent elliptic flow: azimuth modulation of transverse or radial flow in noncentral nucleus-nucleus (A-A) collisions. The nonjet (NJ) quadrupole component exhibits various properties inconsistent with a flow or hydro interpretation, including the observation that NJ-quadrupole centrality variation in $A$-$A$ collisions has no relation to strongly-varying jet modification ("jet quenching") in those collisions commonly attributed to jet interaction with a dense flowing medium. In the present study I report isolation of quadrupole spectra from $p_t$-differential $v_2(p_t)$ data obtained at the relativistic heavy ion collider (RHIC) and large hadron collider (LHCr). I demonstrate that NJ quadrupole spectra have characteristics very different from the single-particle spectra for most hadrons, that quadrupole...

  10. Liver 4DMRI: A retrospective image-based sorting method

    Energy Technology Data Exchange (ETDEWEB)

    Paganelli, Chiara, E-mail: chiara.paganelli@polimi.it [Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milano 20133 (Italy); Summers, Paul [Division of Radiology, Istituto Europeo di Oncologia, Milano 20133 (Italy); Bellomi, Massimo [Division of Radiology, Istituto Europeo di Oncologia, Milano 20133, Italy and Department of Health Sciences, Università di Milano, Milano 20133 (Italy); Baroni, Guido; Riboldi, Marco [Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milano 20133, Italy and Bioengineering Unit, Centro Nazionale di Adroterapia Oncologica, Pavia 27100 (Italy)

    2015-08-15

    Purpose: Four-dimensional magnetic resonance imaging (4DMRI) is an emerging technique in radiotherapy treatment planning for organ motion quantification. In this paper, the authors present a novel 4DMRI retrospective image-based sorting method, providing reduced motion artifacts than using a standard monodimensional external respiratory surrogate. Methods: Serial interleaved 2D multislice MRI data were acquired from 24 liver cases (6 volunteers + 18 patients) to test the proposed 4DMRI sorting. Image similarity based on mutual information was applied to automatically identify a stable reference phase and sort the image sequence retrospectively, without the use of additional image or surrogate data to describe breathing motion. Results: The image-based 4DMRI provided a smoother liver profile than that obtained from standard resorting based on an external surrogate. Reduced motion artifacts were observed in image-based 4DMRI datasets with a fitting error of the liver profile measuring 1.2 ± 0.9 mm (median ± interquartile range) vs 2.1 ± 1.7 mm of the standard method. Conclusions: The authors present a novel methodology to derive a patient-specific 4DMRI model to describe organ motion due to breathing, with improved image quality in 4D reconstruction.

  11. Implementation of $ab$ $initio$ perturbed angular correlation observables for analysis of fluctuating quadrupole interactions

    CERN Document Server

    Barbosa, Marcelo

    A review about the nuclear properties, namely the nuclear moments (magnetic dipole moment and electric quadrupole moment) and their interaction with electromagnetic fields external to the nucleus (hyperfine interactions), as well as the angular distribution of radiation produced by $\\gamma$-decay, is presented. A detailed description about the theory of Perturbed Angular Correlations was done, including the comparison between $\\gamma-\\gamma$- correlations and $e^{-}- \\gamma$ correlations. For dynamic nuclear interactions, an introduction to the theory of stochastic states in PAC was performed. We focused on ab-initio implementation of observables for analyzing fluctuating quadrupole hyperfine interactions on time dependent perturbed angular correlations experiments. The development of computacional codes solving the full problem, adapted to fit data obtained on single crystals or polycrystals for two-state transient fields with any axial symmetry and orientation was the main purpose of this work. The final pa...

  12. Spectroscopic quadrupole moments of high-spin isomers in {sup 193}Pb

    Energy Technology Data Exchange (ETDEWEB)

    Balabanski, D.L. [IKS, University of Leuven, Celestijnenlaan 200 D, B-3001, Leuven (Belgium); Faculty of Physics, St. Kliment Ohridski University of Sofia, BG-1164, Sofia (Bulgaria); Ionescu-Bujor, M.; Iordachescu, A.; Bucurescu, D. [National Institute for Physics and Nuclear Engineering, P.O. Box MG-6, Bucharest (Romania); Bazzacco, D.; Brandolini, F.; Menegazzo, R.; Pavan, P.; Rossi Alvarez, C. [Dipartimento di Fisica dell' Universita di Padova and INFN, Sezione di Padova, Padova (Italy); Chmel, S.; Huebel, H. [ISKP, Universitaet Bonn, D-53115, Bonn (Germany); Danchev, M. [Faculty of Physics, St. Kliment Ohridski University of Sofia, BG-1164, Sofia (Bulgaria); De Poli, M. [Laboratori Nazionali di Legnaro, INFN, Legnaro (Italy); Georgiev, G. [Grand Accelerateur National d' Ions Lourds, F-14076, Caen Cedex 5 (France); Haas, H. [Bereich Festkorperphysik, Hahn-Meitner Institut, D-14109, Berlin (Germany); Marginean, N. [National Institute for Physics and Nuclear Engineering, P.O. Box MG-6, Bucharest (Romania); Laboratori Nazionali di Legnaro, INFN, Legnaro (Italy); Neyens, G.; Vyvey, K. [IKS, University of Leuven, Celestijnenlaan 200 D, B-3001, Leuven (Belgium); Rainovski, G. [Faculty of Physics, St. Kliment Ohridski University of Sofia, BG-1164, Sofia (Bulgaria); Department of Physics, University of Liverpool, L69 7ZE, Liverpool (United Kingdom); Ur, C.A. [National Institute for Physics and Nuclear Engineering, P.O. Box MG-6, Bucharest (Romania); Dipartimento di Fisica dell' Universita di Padova and INFN, Sezione di Padova, Padova (Italy); Frauendorf, S.

    2004-04-01

    The quadrupole interaction of high-spin isomers in {sup 193}Pb implanted into solid Hg cooled at a temperature T=170 K has been investigated by the time-differential perturbed {gamma}-ray angular-distribution method. Spectroscopic quadrupole moment values of vertical stroke Q{sub s} vertical stroke =0.22(2) eb and 0.45(4) eb have been deduced for the 21/2{sup -} and 33/2{sup +} three-neutron states, respectively. A much higher value vertical stroke Q{sub s} vertical stroke =2.84(26) eb has been determined for the 29/2{sup -} isomer, the band head of a magnetic rotational band. (orig.)

  13. Tuning The Cells Of The Accelerating Structure With Rf-quadrupole Doublets

    CERN Document Server

    Bomko, V A; Dyachenko, A F; Kobets, A F; Marynina, E D; Ptukhina, Z E; Tishkin, S S; Zajtsev, B V

    2004-01-01

    The versions of the high frequency quadrupole doublets (RFQD) in heavy ion linear accelerators are discussed. Advantages of focusing of this type over magnetic quadrupoles lie in the simplicity of the structure, and high efficiency and reliability of focusing. In the multi-gap structures, focusing periods contain a sequence of focusing and accelerating cells. The elaborated technique of the local cell adjustment provides the high acceleration rate. Various RFQD versions for the specific peculiarities of accelerating interdigital H-structures are dicussed. Application of the RFQD will allow to increase the efficiency of ion beam focusing and to expand the energy range of the ion being accelerated over 10 MeV/u.

  14. Sternheimer free determination of the 47Ti nuclear quadrupole moment from hyperfine structure measurements

    Science.gov (United States)

    Aydin, R.; Stachowska, E.; Johann, U.; Dembczyński, J.; Unkel, P.; Ertmer, W.

    1990-12-01

    The hyperfine structure (hfs) of 12 metastable states of47Ti has been measured by laser induced fluorescence. 11 of these states have been measured additionally very precisely by a laser-rf double resonance method. Taking into account results of earlier hfs measurements, the hfs of altogether 17 fine structure states has been analyzed by the simultaneous parametrization of the one- and two-body interactions in the atomic hfs for the model space (3 d+4 s) N+2 ( N=2). This gives 16 parameters for the magnetic dipole interaction and 12 parameters for the electric quadrupole interaction. From the model space parameters, obtained from the hfs fit, the nuclear quadrupole moment Q(47Ti)=0.303(24b), has been evaluated at the first time; it is free of Sternheimer corrections up to second order.

  15. Quadrupole Transfer Function for Emittance Measurement

    CERN Document Server

    Cameron, Peter; Jansson, Andreas; Tan, Cheng-Yang

    2008-01-01

    Historically the use of the quadrupole moment measurement has been impeded by the requirement for large dynamic range, as well as measurement sensitivity to beam position. We investigate the use of the transfer function technique [1-3] in combination with the sensitivity and 160dB revolution line rejection of the direct diode detection analog front end [4] to open the possibility of an emittance diagnostic that may be implemented without operational complication, quasi- parasitic to the operation of existing tune measurement systems. Such a diagnostic would be particularly useful as an emittance monitor during acceleration ramp development in machines like RHIC and the LHC.

  16. Multi-Pass Quadrupole Mass Analyzer

    Science.gov (United States)

    Prestage, John D.

    2013-01-01

    Analysis of the composition of planetary atmospheres is one of the most important and fundamental measurements in planetary robotic exploration. Quadrupole mass analyzers (QMAs) are the primary tool used to execute these investigations, but reductions in size of these instruments has sacrificed mass resolving power so that the best present-day QMA devices are still large, expensive, and do not deliver performance of laboratory instruments. An ultra-high-resolution QMA was developed to resolve N2 +/CO+ by trapping ions in a linear trap quadrupole filter. Because N2 and CO are resolved, gas chromatography columns used to separate species before analysis are eliminated, greatly simplifying gas analysis instrumentation. For highest performance, the ion trap mode is used. High-resolution (or narrow-band) mass selection is carried out in the central region, but near the DC electrodes at each end, RF/DC field settings are adjusted to allow broadband ion passage. This is to prevent ion loss during ion reflection at each end. Ions are created inside the trap so that low-energy particles are selected by low-voltage settings on the end electrodes. This is beneficial to good mass resolution since low-energy particles traverse many cycles of the RF filtering fields. Through Monte Carlo simulations, it is shown that ions are reflected at each end many tens of times, each time being sent back through the central section of the quadrupole where ultrahigh mass filtering is carried out. An analyzer was produced with electrical length orders of magnitude longer than its physical length. Since the selector fields are sized as in conventional devices, the loss of sensitivity inherent in miniaturizing quadrupole instruments is avoided. The no-loss, multi-pass QMA architecture will improve mass resolution of planetary QMA instruments while reducing demands on the RF electronics for high-voltage/high-frequency production since ion transit time is no longer limited to a single pass. The

  17. Nuclear quadrupole resonance echoes from hexamethylenetetramine.

    Science.gov (United States)

    Ota, Go; Itozaki, Hideo

    2006-10-01

    We investigated the echo phenomenon of nuclear quadrupole resonance (NQR) from hexamethylenetetramine (HMT). We detected the pure NQR echo signal of HMT with a short pulse interval. The intensity of the echo signal increased as the pulse interval time was decreased. We observed that a clean echo signal was generated even when the pulse interval was shorter than the decay time constant T(2)(*). Since the short interval time gives a strong echo, our result insists that shorter interval time is preferred for the NQR detection.

  18. Precise calculations of the deuteron quadrupole moment

    Energy Technology Data Exchange (ETDEWEB)

    Gross, Franz L. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2016-06-01

    Recently, two calculations of the deuteron quadrupole moment have have given predictions that agree with the measured value to within 1%, resolving a long-standing discrepancy. One of these uses the covariant spectator theory (CST) and the other chiral effective field theory (cEFT). In this talk I will first briefly review the foundations and history of the CST, and then compare these two calculations with emphasis on how the same physical processes are being described using very different language. The comparison of the two methods gives new insights into the dynamics of the low energy NN interaction.

  19. Buoyancy-activated cell sorting using targeted biotinylated albumin microbubbles.

    Directory of Open Access Journals (Sweden)

    Yu-Ren Liou

    Full Text Available Cell analysis often requires the isolation of certain cell types. Various isolation methods have been applied to cell sorting, including fluorescence-activated cell sorting and magnetic-activated cell sorting. However, these conventional approaches involve exerting mechanical forces on the cells, thus risking cell damage. In this study we applied a novel isolation method called buoyancy-activated cell sorting, which involves using biotinylated albumin microbubbles (biotin-MBs conjugated with antibodies (i.e., targeted biotin-MBs. Albumin MBs are widely used as contrast agents in ultrasound imaging due to their good biocompatibility and stability. For conjugating antibodies, biotin is conjugated onto the albumin MB shell via covalent bonds and the biotinylated antibodies are conjugated using an avidin-biotin system. The albumin microbubbles had a mean diameter of 2 μm with a polydispersity index of 0.16. For cell separation, the MDA-MB-231 cells are incubated with the targeted biotin-MBs conjugated with anti-CD44 for 10 min, centrifuged at 10 g for 1 min, and then allowed 1 hour at 4 °C for separation. The results indicate that targeted biotin-MBs conjugated with anti-CD44 antibodies can be used to separate MDA-MB-231 breast cancer cells; more than 90% of the cells were collected in the MB layer when the ratio of the MBs to cells was higher than 70:1. Furthermore, we found that the separating efficiency was higher for targeted biotin-MBs than for targeted avidin-incorporated albumin MBs (avidin-MBs, which is the most common way to make targeted albumin MBs. We also demonstrated that the recovery rate of targeted biotin-MBs was up to 88% and the sorting purity was higher than 84% for a a heterogenous cell population containing MDA-MB-231 cells (CD44(+ and MDA-MB-453 cells (CD44-, which are classified as basal-like breast cancer cells and luminal breast cancer cells, respectively. Knowing that the CD44(+ is a commonly used cancer

  20. An improved infrared technique for sorting pecans

    Science.gov (United States)

    Graeve, Thorsten; Dereniak, Eustace L.; Lamonica, John A., Jr.

    1991-10-01

    This paper presents the results of a study of pecan spectral reflectances. It describes an experiment for measuring the contrast between several components of raw pecan product to be sorted. An analysis of the experimental data reveals high contrast ratios in the infrared spectrum, suggesting a potential improvement in sorting efficiency when separating pecan meat from shells. It is believed that this technique has the potential to dramatically improve the efficiency of current sorting machinery, and to reduce the cost of processing pecans for the consumer market.

  1. Minimal Model Semantics for Sorted Constraint Representation

    Institute of Scientific and Technical Information of China (English)

    廖乐健; 史忠植

    1995-01-01

    Sorted constraint representation is a very useful representation in AI which combines class hierarchies and constraint networks.For such sorted constraint representation,a problem is how to generalize the idea of default inheritance to constraint network,where the attributes in a class or between different classes interact with each other via the network.To give a formal account for the defeasible reasoning in such representation,a general sorted constraint logic is proposed,and a minimal-model semantics for the logic is presented.

  2. Fast Fourier Transform Chlorine Nuclear Quadrupole Resonance Spectroscopy.

    Science.gov (United States)

    D'Iorio, Marie

    A nuclear quadrupole resonance spectrometer operating in the frequency range 1-40 MHz was updated for fast Fourier transform spectroscopy and coupled to a Nicolet 1180 computer and data acquisition system. It was used with a low temperature cryostat for studies shown down to liquid helium temperature and with a high pressure/low temperature system for studies down to liquid nitrogen temperature and up to six kilobars. The study of the ('35)Cl NQR spectrum of K(,2)OsCl(,6) at 298 K and 77 K revealed the presence of a satellite associated with the nearest neighbour chlorines to H('+) ion impurities located at vacant octahedral sties. This result is in agreement with the predictions of a point charge model calculation. A residence time for the H('+) ion was deduced and is consistent with the result obtained from dielectric measurements. A detailed study of the ('35)Cl NQR frequency in K(,2)ReCl(,6) was performed in the temperature range 85 - 130K where two structural phase transitions occur, and at pressures from 1 to 2643 bars. A number of unusual features were revealed and discussed as the possible signature of incommensurate behavior. The primary effect of the pressure was to alter the temperatures at which the phase transitions occurred. Contrary to the behavior expected, the transition temperature for the antiferrorotative transition has a negative pressure coefficient. The spin-lattice and spin-spin relaxation times for the ('35)Cl and ('37)Cl isotopes of the one dimensional XY system, PrCl(,3), were measured at 4.2K. The spin-lattice relaxation is exponential and dominated by magnetic dipole -dipole interactions. The spin-spin relaxation is non-exponential and dominated by electric quadrupolar interactions arising from the coupling of the electric dipole moment at the praseodymium site and the quadrupole moment of the chlorine ion. The temperature dependence of the spin-spin relaxation time was investigated. At 17.4 K both magnetic dipolar and electric

  3. Dynamic Evolution of an X-shaped Structure above a Trans-equatorial Quadrupole Solar Active Region Group

    CERN Document Server

    Sun, J Q; Guo, Y; Ding, M D; Li, Y

    2014-01-01

    In the solar corona, magnetic reconnection usually takes place at the singular configuration of magnetic field, in particular near a magnetic null owing to its high susceptibility to perturbations. In this Letter, we report a rare X-shaped structure, encompassing a magnetic null, above a trans-equatorial quadrupole active region group that is well observed by the Atmospheric Imaging Assembly (AIA). The observations show that this X-shaped structure is visible in all AIA EUV passbands and stably exists for days. However, possibly induced by flare activities at the northern part of the quadrupole active region group, the X-shaped structure starts to destabilize and meanwhile a jet erupted near its center at 15:05 UT on 2013 October 7. Through the non-linear force-free field modeling, we identify a magnetic null, which is above the quadrupole polarities and well corresponds to the X-shaped structure. After the jet eruption, the temperature and emission measure of the plasma near the X-shaped structure rise from ...

  4. Consistent quadrupole-octupole collective model

    Science.gov (United States)

    Dobrowolski, A.; Mazurek, K.; Góźdź, A.

    2016-11-01

    Within this work we present a consistent approach to quadrupole-octupole collective vibrations coupled with the rotational motion. A realistic collective Hamiltonian with variable mass-parameter tensor and potential obtained through the macroscopic-microscopic Strutinsky-like method with particle-number-projected BCS (Bardeen-Cooper-Schrieffer) approach in full vibrational and rotational, nine-dimensional collective space is diagonalized in the basis of projected harmonic oscillator eigensolutions. This orthogonal basis of zero-, one-, two-, and three-phonon oscillator-like functions in vibrational part, coupled with the corresponding Wigner function is, in addition, symmetrized with respect to the so-called symmetrization group, appropriate to the collective space of the model. In the present model it is D4 group acting in the body-fixed frame. This symmetrization procedure is applied in order to provide the uniqueness of the Hamiltonian eigensolutions with respect to the laboratory coordinate system. The symmetrization is obtained using the projection onto the irreducible representation technique. The model generates the quadrupole ground-state spectrum as well as the lowest negative-parity spectrum in 156Gd nucleus. The interband and intraband B (E 1 ) and B (E 2 ) reduced transition probabilities are also calculated within those bands and compared with the recent experimental results for this nucleus. Such a collective approach is helpful in searching for the fingerprints of the possible high-rank symmetries (e.g., octahedral and tetrahedral) in nuclear collective bands.

  5. Engineering a Cache-Oblivious Sorting Algorithm

    DEFF Research Database (Denmark)

    Brodal, Gerth Stølting; Fagerberg, Rolf; Vinther, Kristoffer

    2007-01-01

    This paper is an algorithmic engineering study of cache-oblivious sorting. We investigate by empirical methods a number of implementation issues and parameter choices for the cache-oblivious sorting algorithm Lazy Funnelsort, and compare the final algorithm with Quicksort, the established standard...... for comparison-based sorting, as well as with recent cache-aware proposals. The main result is a carefully implemented cache-oblivious sorting algorithm, which our experiments show can be faster than the best Quicksort implementation we are able to find, already for input sizes well within the limits of RAM....... It is also at least as fast as the recent cache-aware implementations included in the test. On disk the difference is even more pronounced regarding Quicksort and the cache-aware algorithms, whereas the algorithm is slower than a careful implementation of multiway Mergesort such as TPIE....

  6. Filter-less submicron hydrodynamic size sorting.

    Science.gov (United States)

    Fouet, M; Mader, M-A; Iraïn, S; Yanha, Z; Naillon, A; Cargou, S; Gué, A-M; Joseph, P

    2016-02-21

    We propose a simple microfluidic device able to separate submicron particles (critical size ∼0.1 μm) from a complex sample with no filter (minimum channel dimension being 5 μm) by hydrodynamic filtration. A model taking into account the actual velocity profile and hydrodynamic resistances enables prediction of the chip sorting properties for any geometry. Two design families are studied to obtain (i) small sizes within minutes (low-aspect ratio, two-level chip) and (ii) micron-sized sorting with a μL flow rate (3D architecture based on lamination). We obtain quantitative agreement of sorting performances both with experiments and with numerical solving, and determine the limits of the approach. We therefore demonstrate a passive, filter-less sub-micron size sorting with a simple, robust, and easy to fabricate design.

  7. Visual ergonomics interventions in mail sorting facilities.

    Science.gov (United States)

    Hemphälä, H; Hansson, G-Å; Dahlqvist, C; Eklund, J

    2012-01-01

    This study was performed between 2004 and 2011 at mail sorting facilities in Sweden. During this time, different interventions were performed. The first was a lighting intervention that had a positive impact on the postal workers, especially those with eyestrain. A new lighting system also improved the illuminance and gave better light distribution. The second intervention involved new personal spectacles for the postal workers who needed them and this had a positive effect on eyestrain. The third intervention involved a specific type of sorting spectacles for the postal workers who already used progressive lenses privately. The reading distances that the postal workers had while sorting the mail was inverted to the distances in their regular progressive lenses. The new sorting spectacles had a positive effect on head postures and on muscular activity.

  8. Efficient sorting of Bessel beams [Conference paper

    CSIR Research Space (South Africa)

    Mhlanga, T

    2013-02-01

    Full Text Available A procedure to efficiently sort orbital angular momentum (OAM) states of light, by performing a Cartesian to log-polar coordinate transformation which translates helically phased beams into a transverse phase gradient, currently exists1. We...

  9. Quantum Database Search can do without Sorting

    CERN Document Server

    Patel, A

    2001-01-01

    Sorting is a fundamental computational process, which facilitates subsequent searching of a database. It can be thought of as factorisation of the search process. The location of a desired item in a sorted database can be found by classical queries that inspect one letter of the label at a time. For an unsorted database, no such classical quick search algorithm is available. If the database permits quantum queries, however, then mere digitisation is sufficient for efficient search. Sorting becomes redundant with the quantum superposition of states. A quantum algorithm is written down which locates the desired item in an unsorted database a factor of two faster than the best classical algorithm can in a sorted database. This algorithm has close resemblance to the assembly process in DNA replication.

  10. Card Sorts, State Tests, and Meaningful Mathematics

    Science.gov (United States)

    Chauvot, Jennifer B.; Benson, Sharon L. D.

    2008-01-01

    This article shares card-sorting activities that involve state-mandated test items to use with prospective and practicing mathematics teachers to teach about accountability measures while exploring reform-minded mathematics instruction recommendations. (Contains 2 figures.)

  11. Sorting it out: regulation of exosome loading.

    Science.gov (United States)

    Villarroya-Beltri, Carolina; Baixauli, Francesc; Gutiérrez-Vázquez, Cristina; Sánchez-Madrid, Francisco; Mittelbrunn, María

    2014-10-01

    Extracellular vesicles (EVs), a term that includes both exosomes of endocytic origin and vesicles derived from plasma membranes, are continuously secreted by cells to the extracellular environment, and represent a novel vehicle for cell-cell communication. Exosomes contain specific repertoires of proteins and RNAs, indicating the existence of mechanisms that control the sorting of molecules into them. Although the molecular mechanisms that regulate the loading of proteins into exosomes have been studied for years, the sorting of RNA has been elusive until recently. Here we review the molecular mechanisms that control the sorting of molecules into exosomes, with special attention to the sorting of RNA. We also discuss how the cellular context affects the composition of exosomes, and thus the outcome of the communication between the exosome-producer and recipient cells, with particular focus on the communication between tumor cells and with cells of the tumor microenvironment.

  12. Another Definition of Order—Sorted Algebra

    Institute of Scientific and Technical Information of China (English)

    何自强

    1998-01-01

    In this paper the definition of order-sorted algebra is generalized by introducing transformation functions between subtypes and supertypes.According to our definition,a type needn't be a subset of its supertype and a record model may form an order-sorted algebra.A new definition of equation is given.It has also been proved that equational theories and describing single inheritance have the initial model.

  13. Detecting body cavity bombs with nuclear quadrupole resonance

    Science.gov (United States)

    Collins, Michael London

    Nuclear Quadrupole Resonance (NQR) is a technology with great potential for detecting hidden explosives. Past NQR research has studied the detection of land mines and bombs concealed within luggage and packages. This thesis focuses on an NQR application that has received less attention and little or no publicly available research: detecting body cavity bombs (BCBs). BCBs include explosives that have been ingested, inserted into orifices, or surgically implanted. BCBs present a threat to aviation and secure facilities. They are extremely difficult to detect with the technology currently employed at security checkpoints. To evaluate whether or not NQR can be used to detect BCBs, a computational model is developed to assess how the dielectric properties of biological tissue affect the radio frequency magnetic field employed in NQR (0.5-5MHz). The relative permittivity of some biological tissue is very high (over 1,000 at 1MHz), making it conceivable that there is a significant effect on the electromagnetic field. To study this effect, the low-frequency approximation known as the Darwin model is employed. First, the electromagnetic field of a coil is calculated in free space. Second, a dielectric object or set of objects is introduced, and the free-space electric field is modified to accommodate the dielectric object ensuring that the relevant boundary conditions are obeyed. Finally, the magnetic field associated with the corrected electric field is calculated. This corrected magnetic field is evaluated with an NQR simulation to estimate the impact of dielectric tissue on NQR measurements. The effect of dielectric tissue is shown to be small, thus obviating a potential barrier to BCB detection. The NQR model presented may assist those designing excitation and detection coils for NQR. Some general coil design considerations and strategies are discussed.

  14. Automatic spike sorting using tuning information.

    Science.gov (United States)

    Ventura, Valérie

    2009-09-01

    Current spike sorting methods focus on clustering neurons' characteristic spike waveforms. The resulting spike-sorted data are typically used to estimate how covariates of interest modulate the firing rates of neurons. However, when these covariates do modulate the firing rates, they provide information about spikes' identities, which thus far have been ignored for the purpose of spike sorting. This letter describes a novel approach to spike sorting, which incorporates both waveform information and tuning information obtained from the modulation of firing rates. Because it efficiently uses all the available information, this spike sorter yields lower spike misclassification rates than traditional automatic spike sorters. This theoretical result is verified empirically on several examples. The proposed method does not require additional assumptions; only its implementation is different. It essentially consists of performing spike sorting and tuning estimation simultaneously rather than sequentially, as is currently done. We used an expectation-maximization maximum likelihood algorithm to implement the new spike sorter. We present the general form of this algorithm and provide a detailed implementable version under the assumptions that neurons are independent and spike according to Poisson processes. Finally, we uncover a systematic flaw of spike sorting based on waveform information only.

  15. Differentially pumped dual linear quadrupole ion trap mass spectrometer

    Science.gov (United States)

    Owen, Benjamin C.; Kenttamaa, Hilkka I.

    2015-10-20

    The present disclosure provides a new tandem mass spectrometer and methods of using the same for analyzing charged particles. The differentially pumped dual linear quadrupole ion trap mass spectrometer of the present disclose includes a combination of two linear quadrupole (LQIT) mass spectrometers with differentially pumped vacuum chambers.

  16. Differentially pumped dual linear quadrupole ion trap mass spectrometer

    Science.gov (United States)

    Owen, Benjamin C.; Kenttamaa, Hilkka I.

    2016-11-15

    The present disclosure provides a new tandem mass spectrometer and methods of using the same for analyzing charged particles. The differentially pumped dual linear quadrupole ion trap mass spectrometer of the present disclose includes a combination of two linear quadrupole (LQIT) mass spectrometers with differentially pumped vacuum chambers.

  17. Rescuing the nonjet (NJ) azimuth quadrupole from the flow narrative

    CERN Document Server

    Trainor, Thomas A

    2016-01-01

    According to the flow narrative commonly applied to high-energy nuclear collisions a cylindrical-quadrupole component of 1D azimuth angular correlations is conventionally denoted by quantity $v_2$ and interpreted to represent elliptic flow. Jet angular correlations may also contribute to $v_2$ data as "nonflow" depending on the method used to calculate $v_2$, but 2D graphical methods are available to insure accurate separation. The nonjet (NJ) quadrupole has various properties inconsistent with a flow interpretation, including the observation that NJ quadrupole centrality variation in A-A collisions has no relation to strongly-varying jet modification ("jet quenching") in those collisions commonly attributed to jet interaction with a flowing dense medium. In this presentation I describe isolation of quadrupole spectra from pt-differential $v_2(p_t)$ data from the RHIC and LHC. I demonstrate that quadrupole spectra have characteristics very different from the single-particle spectra for most hadrons, that quad...

  18. Giant magnetic quadrupole resonance studied with 180 deg. electron scattering

    CERN Document Server

    Neumann-Cosel, P V

    1999-01-01

    The nuclei sup 4 sup 8 Ca and sup 9 sup 0 Zr were investigated in 180 deg. high-resolution inelastic electron scattering for momentum transfers q approx =0.35-0.8 fm sup - sup 1. Complete M2 strength distributions could be extracted in both nuclei up to excitation energies of about 15 MeV utilizing a fluctuation analysis technique. Second-RPA calculations successfully describe the experimentally observed strong fragmentation of the M2 mode. The quenching of the spin part is found to be comparable to the M1 case, contrary to previous claims suggesting a stronger reduction. A quantitative reproduction of the data requires the presence of appreciable orbital strength which can be interpreted as a torsional elastic vibration (the so-called twist mode).

  19. Prototype HL-LHC magnet undergoes testing

    CERN Multimedia

    Corinne Pralavorio

    2016-01-01

    A preliminary short prototype of the quadrupole magnets for the High-Luminosity LHC has passed its first tests.   The first short prototype of the quadrupole magnet for the High Luminosity LHC. (Photo: G. Ambrosio (US-LARP and Fermilab), P. Ferracin and E. Todesco (CERN TE-MSC)) Momentum is gathering behind the High-Luminosity LHC (HL-LHC) project. In laboratories on either side of the Atlantic, a host of tests are being carried out on the various magnet models. In mid-March, a short prototype of the quadrupole magnet underwent its first testing phase at the Fermilab laboratory in the United States. This magnet is a pre-prototype of the quadrupole magnets that will be installed near to the ATLAS and CMS detectors to squeeze the beams before collisions. Six quadrupole magnets will be installed on each side of each experiment, giving a total of 24 magnets, and will replace the LHC's triplet magnets. Made of superconducting niobium-tin, the magnets will be more powerful than their p...

  20. Immunophenotypic comparison of heterogenous non-sorted versus sorted mononuclear cells from human umbilical cord blood: a novel cell enrichment approach.

    Science.gov (United States)

    Indumathi, S; Harikrishnan, R; Rajkumar, J S; Dhanasekaran, M

    2015-01-01

    Human umbilical cord blood (hUCB) has been the preferred source of stem cells for the treatment of haematological malignancies and genetic disorders. This is primarily due to its non-invasiveness, high accessibility with relative ease of isolation. Still failures do prevail due to its heterogeneity and lesser frequency of MSC identified in UCB. This study, thus, employs a cell enrichment technology to improve its therapeutic efficacy. This was achieved by immunophenotypic comparison of stem cells isolated from the heterogenous non-sorted mononuclear cells (MNCs), linage depleted (Lin+ and Lin-) fractions obtained from magnetic activated cell sorter (MACS) and sorted MNCs obtained by fluorescent activated cell sorter (FACS). The markers under consideration were CD29, CD44, CD34, CD45, CD133, CD90 and CD117. FACS sorted MNCs were rich in naive stem cell population, whereas non-sorted MNCs and lineage depleted fractions were found to be rich in progenitors. Thus, we suggest that a combination therapy of both sorted population might serve as an alternative valuable tool in treating haematologic/genetic disorders. However, further research on cell enrichment technology might give a clue for improved cell based therapy in regenerative medicine.

  1. Chemokines as novel and versatile reagents for flow cytometry and cell sorting.

    Science.gov (United States)

    Le Brocq, Michelle L; Fraser, Alasdair R; Cotton, Graham; Woznica, Kerry; McCulloch, Clare V; Hewit, Kay D; McKimmie, Clive S; Nibbs, Robert J B; Campbell, John D M; Graham, Gerard J

    2014-06-15

    Cell therapy regimens are frequently compromised by low-efficiency cell homing to therapeutic niches. Improvements in this regard would enhance effectiveness of clinically applicable cell therapy. The major regulators of tissue-specific cellular migration are chemokines, and therefore selection of therapeutic cellular populations for appropriate chemokine receptor expression would enhance tissue-homing competence. A number of practical considerations preclude the use of Abs in this context, and alternative approaches are required. In this study, we demonstrate that appropriately labeled chemokines are at least as effective in detecting their cognate receptors as commercially available Abs. We also demonstrate the utility of biotinylated chemokines as cell-sorting reagents. Specifically, we demonstrate, in the context of CCR7 (essential for lymph node homing of leukocytes), the ability of biotinylated CCL19 with magnetic bead sorting to enrich for CCR7-expressing cells. The sorted cells demonstrate improved CCR7 responsiveness and lymph node-homing capability, and the sorting is effective for both T cells and dendritic cells. Importantly, the ability of chemokines to detect CCR7, and sort for CCR7 positivity, crosses species being effective on murine and human cells. This novel approach to cell sorting is therefore inexpensive, versatile, and applicable to numerous cell therapy contexts. We propose that this represents a significant technological advance with important therapeutic implications.

  2. Two-dimensional Nutation Echo Nuclear Quadrupole Resonance Spectroscopy

    Science.gov (United States)

    Harbison, Gerard S.; Slokenbergs, Andris

    1990-04-01

    We discuss two new two-dimensional nuclear quadrupole resonance experiments, both based on the principle of nutation spectroscopy, which can be used to determine the asymmetry parameter, and thus the full quadrupolar tensor, of spin-3/2 nuclei at zero applied magnetic field. The first experiment is a simple nutation pulse sequence in which the first time period (t1) is the duration of the radiofrequency exciting pulse; and the second (t2) is the normal free-precession of a quadrupolar nucleus at zero-field. After double Fourier-transformation, the result is a 2 D spectrum in which the first frequency dimension is the nutation spectrum for the quadrupolar nucleus at zero-field. For polycrystalline samples this sequence generates powder lineshapes; the position of the singularities, in these lineshapes can be used to determine the asymmetry parameters η in a very straightforward manner, η has previously only been obtainable using Zeeman perturbed NQR methods. The second sequence is the same nutation experiment with a spin-echo pulse added. The virtue of this refocussing pulse is that it allows acquisition of nutation spectra from samples with arbitrary inhomogeneous linewidth; thus, asymmetry parameters can be determined even where the quadrupolar resonance is wider than the bandwidth of the spectrometer. Experimental examples of 35Cl, 81Br and 63Cu nutation and nutation-echo spectra are presented.

  3. TOUTATIS: A radio frequency quadrupole code

    Directory of Open Access Journals (Sweden)

    Romuald Duperrier

    2000-12-01

    Full Text Available A cw high power linear accelerator can only work with very low particle losses and structure activation. At low energy, the radio frequency quadrupole (RFQ is an accelerator element that is very sensitive to losses. To design this structure, a good understanding of the beam dynamics is required. Generally, the reference code PARMTEQM is enough to design the accelerator. TOUTATIS has been written with the goals of cross-checking results and obtaining more reliable dynamics. This paper relates the different numerical methods used in the code. It is time based, using multigrids methods and adaptive mesh for a fine description of the forces without being time consuming. The field is calculated through a Poisson solver and the vanes are fully described, allowing it to properly simulate the coupling gaps and the RFQs extremities. Theoretical and experimental tests are also described and show a good agreement between simulations and reference cases.

  4. 人外周血树突状细胞体外稳定培养方法的建立及与磁珠法的比较%Establishment of in vitro stable culture of human peripheral blood dendritic cells and its comparation with magnetic activated cell sorting

    Institute of Scientific and Technical Information of China (English)

    单骄宇; 刘弓伯; 吐尔洪江·吐尔逊; 张雪; 阿尔孜古丽·吐逊; 林仁勇; 温浩

    2010-01-01

    Objective To establish a economic and stable method to induce and culture dendritic cells (DCs) from peripheral blood of human being, and compare with the magnetic activated cell sorting. Methods Monocytes were isolated from health donors peripheral blood mononuclear cells(PBMC) by density gradient separation,cultured and compared with that of cells isolated by the magnetic activated cell sorting or adherent culture,respectively. PBMC were cultured with recombinant human granulocyte macrophage colony stimulating factor (rhGM-CSF) and recombinant human interleukin-4(rhIL-4) for 6 days to induce the growth of DCs. Morphological changes was observed under inverted microscope. Meanwhile, cell viability was tested at the 3rd, 5th, 6th day,respectively. The phenotypes, like CD14, CDla, HLA-DR were analyzed with flow cytometry after PBMC were adherent cultured for 1, 2, 5 h. After adding human recombinant cytokines, the phenotypes of acquired cells surface markers, CD14, CD1a, CD86, CD83 and HLA-DR would be detected and compared with flow cytometry. T cells proliferating activity was determined by allogeneic mixed lymphocyte reaction in vitro. Results After adherent culture for 2 h, the acquired DCs showed typical morphology. Cell viability was decreased at days 5th, 6th[(53.333 ±5.774)%,(38.333 ± 7.638)%] than that at day of 3rd[(68.667 ± 3.215)%, all P < 0.05] with the magnetic activated cell sorting, but with adherent culture method, the difference was not statistically significant (F = 0.737,P> 0.05) at days of 3rd, 5th, 6th[(92.667 ± 3.055)%,(94.000 ± 1.000)%,(94.667 ± 1.528)%]. Moreover,compared with the magnetic activated cell sorting, there were differences in cell viability of adherent culture method at days of 3rd, 5th, 6th(t = 9.374, 12.021,12.527, all P < 0.05). Before and after using the magnetic activated cell sorting, the expression of CD14 were (32.457 ± 12.351) %, (41.914 ± 14.858)%, respectively. The difference was not statistically

  5. Laser ablation cell sorting in scanning cytometry

    Science.gov (United States)

    Shen, Feimo; Price, Jeffrey H.

    2001-05-01

    Flow cytometry has been an important tool for automated cells sorting. However, the lack of good sensitivity prevents it from being used for rare events sorting; furthermore, fragile cells, anchorage-dependent cells, and clump forming cells cannot be sorted this way. A fully automated, high-speed scanning cytometer with autofocus and image segmentation is capable of accurately locating contaminant cells in a monolayer cell population. A laser ablation system was incorporated into the cytometer to negatively sort out the unwanted cells by applying a focused, ultra-short laser pulse (sub-micron diameter, pulse duration = 4 nsec, wavelength - 500 nm) to each targeted cell. Due to the high power density (approximately 1010 W/cm2) that was present at the focal point, disruptive mechanical forces were generated and were responsible for the kill. Fluorescently stained NIH-3T3 fibroblast cells were used as a model contaminant target ells in an unstained NIH-3T3 population to determine the identification-kill effectiveness. The contaminant cells were stained with the fluorochrome CellTracker Blue CMAC, whereas the background cells were left intact. Ablation pulses were applied in frame-by-frame increment batches to the cell culture on the microscope. The negative sorting effectiveness was analyzed by automatically re-scanning the post-ablation cell culture in phase contrast and propidium iodide stained epi fluorescent fields to verify cell death.

  6. MAGNET

    CERN Multimedia

    by B. Curé

    2011-01-01

    The magnet operation was very satisfactory till the technical stop at the end of the year 2010. The field was ramped down on 5th December 2010, following the successful regeneration test of the turbine filters at full field on 3rd December 2010. This will limit in the future the quantity of magnet cycles, as it is no longer necessary to ramp down the magnet for this type of intervention. This is made possible by the use of the spare liquid Helium volume to cool the magnet while turbines 1 and 2 are stopped, leaving only the third turbine in operation. This obviously requires full availability of the operators to supervise the operation, as it is not automated. The cryogenics was stopped on 6th December 2010 and the magnet was left without cooling until 18th January 2011, when the cryoplant operation resumed. The magnet temperature reached 93 K. The maintenance of the vacuum pumping was done immediately after the magnet stop, when the magnet was still at very low temperature. Only the vacuum pumping of the ma...

  7. Four-dimensional transverse beam matrix measurement using the multiple-quadrupole scan technique

    Directory of Open Access Journals (Sweden)

    Eduard Prat

    2014-05-01

    Full Text Available Accurate measurements of the transverse beam properties are essential to understand and optimize particle beams. We present an optimized method that uses three quadrupole magnets and one profile monitor to measure the full 4D transverse matrix of the beam. The method has been applied to the SwissFEL Injector Test Facility (SITF at the Paul Scherrer Institute (Villigen. The SITF is the principal test bed and demonstration plant for the SwissFEL project, which aims at realizing a hard-x-ray free-electron laser in 2017. Simulations, measurements, and results of cross-plane coupling correction are presented.

  8. Development of Superconducting Tuning Quadrupole Corrector (MQT) Prototypes for the LHC

    CERN Document Server

    Allitt, M; Hobl, A; Ijspeert, Albert; Karppinen, M; Krischel, D; Mazet, J; Salminen, J; Schillo, M; Senis, R; Walckiers, L

    2002-01-01

    The main quadrupoles of the Large Hadron Collider (LHC) are connected in families of focusing and defocusing magnets. In order to make tuning corrections in the machine a number of quadrupole corrector magnets (designated MQT) are necessary. These 56 mm diameter aperture magnets have to be compact, with a maximum length of 395 mm and a coil radial thickness of 5 to 7.5 mm, while generating a minimum field gradient of 110 T/m. Two design options have been explored, both using the "counter-winding" system developed at CERN for the fabrication of low cost corrector coils. The first design, with the poles composed of two double-pancake coils, each counter-wound using a single wire, superposed to create 4-layer coils, was developed and built by ACCEL Instruments GmbH. A second design where single coils were counter-wound using a 3-wire ribbon to obtain 6-layer coils was developed at CERN. This paper describes the two designs and reports on the performance of the prototypes during testing.

  9. Energy Extraction Resistors for the Main Dipole and Quadrupole Circuits of the LHC

    CERN Document Server

    Dahlerup-Petersen, K; Popov, V; Sytchev, V V; Vasilev, L B; Zubko, V G

    2000-01-01

    When the LHC will be operating at its maximum beam energy, its superconducting dipole chains store a total magnetic energy of more than 11 GJ. At the same time, the QF and QD quadrupole circuits store a total energy of 400 MJ. Even with the sectorisation of each of the three principal power circuits into eight individually powered segments, the stored energy of a single circuit is considerable. During normal operation the energy in the dipole circuits is safely returned to the mains grid, using the thyristor-based, 'booster' unit of the power converters, operating in inversion. For the quadrupole chains, where the converter is of a mono-polar topology, the stored energy is dissipated into the resistive part of the warm d.c. power lines (busbars and cables) in a slow, controlled run-down. When a magnet quenches, however, such a slow energy transfer, taking 20 minutes from the rated LHC current, will not be possible. The 'cold' diode, taking over the magnet current in case of a quench, will not survive this slo...

  10. Flow karyotyping and sorting of human chromosomes

    Energy Technology Data Exchange (ETDEWEB)

    Gray, J.W.; Lucas, J.; Peters, D.; Pinkel, D.; Trask, B.; van den Engh, G.; Van Dilla, M.A.

    1986-07-16

    Flow cytometry and sorting are becoming increasingly useful as tools for chromosome classfication and for the detection of numerical and structural chromosome aberrations. Chromosomes of a single type can be purified with these tools to facilitate gene mapping or production of chromosome specific recombinant DNA libraries. For analysis of chromosomes with flow cytometry, the chromosomes are extracted from mitotic cells, stained with one or more fluorescent dyes and classified one-by-one according to their dye content(s). Thus, the flow approach is fundamentally different than conventional karyotyping where chromosomes are classified within the context of a metaphase spread. Flow sorting allows purification of chromosomes that can be distinguished flow cytometrically. The authors describe the basic principles of flow cytometric chromosome classification i.e. flow karyotyping, and chromosome sorting and describe several applications. 30 refs., 8 figs.

  11. Applications of cell sorting in biotechnology

    Directory of Open Access Journals (Sweden)

    Mattanovich Diethard

    2006-03-01

    Full Text Available Abstract Due to its unique capability to analyze a large number of single cells for several parameters simultaneously, flow cytometry has changed our understanding of the behavior of cells in culture and of the population dynamics even of clonal populations. The potential of this method for biotechnological research, which is based on populations of living cells, was soon appreciated. Sorting applications, however, are still less frequent than one would expect with regard to their potential. This review highlights important contributions where flow cytometric cell sorting was used for physiological research, protein engineering, cell engineering, specifically emphasizing selection of overproducing cell lines. Finally conclusions are drawn concerning the impact of cell sorting on inverse metabolic engineering and systems biology.

  12. Optimization of Superconducting Focusing Quadrupoles for the HighCurrent Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Sabbi, GianLuca; Gourlay, Steve; Gung, Chen-yu; Hafalia, Ray; Lietzke, Alan; Martovetski, Nicolai; Mattafirri, Sara; Meinke, Rainer; Minervini, Joseph; Schultz, Joel; Seidl, Peter

    2005-09-16

    The Heavy Ion Fusion (HIF) program is progressing through a series of physics and technology demonstrations leading to an inertial fusion power plant. The High Current Experiment (HCX) at Lawrence Berkeley National Laboratory is exploring the physics of intense beams with high line-charge density. Superconducting focusing quadrupoles have been developed for the HCX magnetic transport studies. A baseline design was selected following several pre-series models. Optimization of the baseline design led to the development of a first prototype that achieved a conductor-limited gradient of 132 T/m in a 70 mm bore, without training, with measured field errors at the 0.1% level. Based on these results, the magnet geometry and fabrication procedures were adjusted to improve the field quality. These modifications were implemented in a second prototype. In this paper, the optimized design is presented and comparisons between the design harmonics and magnetic measurements performed on the new prototype are discussed.

  13. Design of the Main Magnets of the SESAME Storage Ring

    CERN Document Server

    Milanese, A; Shehab, M

    2014-01-01

    This paper describes the magnetic design of the main magnets of the SESAME storage ring. The 16 dipoles are combined function bending magnets, designed with an adjustable iron shimming scheme. The 64 quadrupoles are of two different lengths and strengths. The 64 sextupoles are optimized for field quality in 3D without end pole chamfers and they include additional coils to provide a horizontal/vertical dipole and a skew quadrupole terms.

  14. Optical cell sorting with multiple imaging modalities

    DEFF Research Database (Denmark)

    Banas, Andrew; Carrissemoux, Caro; Palima, Darwin

    2017-01-01

    techniques. Scattering forces from beams actuated via efficient phase-only efficient modulation has been adopted. This has lowered the required power for sorting cells to a tenth of our previous approach, and also makes the cell sorter safer for use in clinical settings. With the versatility of dynamically...... programmable phase spatial light modulators, a plurality of light shaping techniques, including hybrid approaches, can be utilized in cell sorting....... healthy cells. With the richness of visual information, a lot of microscopy techniques have been developed and have been crucial in biological studies. To utilize their complementary advantages we adopt both fluorescence and brightfield imaging in our optical cell sorter. Brightfield imaging has...

  15. Order-Sorted Parameterization and Induction

    Science.gov (United States)

    Meseguer, José

    Parameterization is one of the most powerful features to make specifications and declarative programs modular and reusable, and our best hope for scaling up formal verification efforts. This paper studies order-sorted parameterization at three different levels: (i) its mathematical semantics; (ii) its operational semantics by term rewriting; and (iii) the inductive reasoning principles that can soundly be used to prove properties about such specifications. It shows that achieving the desired properties at each of these three levels is a considerably subtler matter than for many-sorted specifications, but that such properties can be attained under reasonable conditions.

  16. MODELING WORK OF SORTING STATION USING UML

    Directory of Open Access Journals (Sweden)

    O. V. Gorbova

    2014-12-01

    Full Text Available Purpose. The purpose of this paper is the construction of methods and models for the graphical representation process of sorting station, using the unified modeling language (UML. Methodology. Methods of graph theory, finite automata and the representation theory of queuing systems were used as the methods of investigation. A graphical representation of the process was implemented with using the Unified Modeling Language UML. The sorting station process representation is implemented as a state diagram and actions through a set of IBM Rational Rose. Graphs can show parallel operation of sorting station, the parallel existence and influence of objects process and the transition from one state to another. The IBM Rational Rose complex allows developing a diagram of work sequence of varying degrees of detailing. Findings. The study has developed a graphical representation method of the process of sorting station of different kind of complexity. All graphical representations are made using the UML. They are represented as a directed graph with the states. It is clear enough in the study of the subject area. Applying the methodology of the representation process, it allows becoming friendly with the work of any automation object very fast, and exploring the process during algorithms construction of sorting stations and other railway facilities. This model is implemented with using the Unified Modeling Language (UML using a combination of IBM Rational Rose. Originality. The representation process of sorting station was developed by means of the Unified Modeling Language (UML use. Methodology of representation process allows creating the directed graphs based on the order of execution of the works chain, objects and performers of these works. The UML allows visualizing, specifying, constructing and documenting, formalizing the representation process of sorting station and developing sequence diagrams of works of varying degrees of detail. Practical

  17. Radiation-induced effects on the sensors of the Hydrostatic Leveling System for the LHC low-beta quadrupoles

    CERN Document Server

    Dimovasili, E; Mainaud-Durand, H; Marin, A; Ossart, F; Wijnands, Thijs

    2005-01-01

    The dose rate dependence of the Hydrostatic Leveling System (HLS) for the final focusing quadrupole magnets in the Large Hadron collider is discussed. At high dose rates, ionization of the air inside the sensors causes charge deposition and this perturbs the position measurement. A model is presented that corrects the HLS signal offset as a function of the dose rate. The model compares the HLS with condenser ionization chambers and in this note the results of the comparison are presented.

  18. Derivative Hartree-Fock approach to molecular Sternheimer shielding. Calculation of intermolecular influence on nuclear quadrupole coupling

    Science.gov (United States)

    Augspurger, Joseph D.; Dykstra, Clifford E.

    1993-08-01

    Molecular Sternheimer shielding constants, γ, the proportionality constants relating the electric field gradient at a quadrupolar nucleus to an external electric field gradient are usually introduced phenomenologically. In this report, we take a comprehensive view of the sensitivity of the electric field gradient at a nucleus to arbitrary external electrical potentials and we show how the response can be obtained from analytically determined properties via derivative Hartree-Fock theory. From application of this ab initio technique, values have been obtained for the first and second order changes in nuclear quadrupole coupling with respect to external fields and field gradients, as well as nearby ideal multipole moments, for HCN and HCl. These values have been used to evaluate the change in the nuclear quadrupole coupling for several weakly bound complexes and to provide a nonempirical approach to relative effects on Sternheimer shielding. In weak molecular complexes, the effect of uniform fields can be as sizable as the effect of external field gradients in the overall change in nuclear quadrupole coupling, and so the underlying issue of convergence of multipolar expansions is considered over a range of geometries. This is important for structural interpretations of both nuclear magnetic resonance (NMR) and microwave data, and a simple formula, representing a practical point of truncation, is presented for quadrupole coupling analysis.

  19. Spin and quadrupole contributions to the motion of astrophysical binaries

    CERN Document Server

    Steinhoff, Jan

    2014-01-01

    Compact objects in general relativity approximately move along geodesics of spacetime. It is shown that the corrections to geodesic motion due to spin (dipole), quadrupole, and higher multipoles can be modeled by an extension of the point mass action. The quadrupole contributions are discussed in detail for astrophysical objects like neutron stars or black holes. Implications for binaries are analyzed for a small mass ratio situation. There quadrupole effects can encode information about the internal structure of the compact object, e.g., in principle they allow a distinction between black holes and neutron stars, and also different equations of state for the latter. Furthermore, a connection between the relativistic oscillation modes of the object and a dynamical quadrupole evolution is established.

  20. ISR Superconducting Quadrupole under test in its cryostat

    CERN Multimedia

    1979-01-01

    One of the Superconducting Quadrupoles for the ISR high luminosity (low-beta) insertion is seen here during final test in building 230 before installation in the ISR. See also photos 7812609X and 7702690X.

  1. End view of ISR Superconducting Quadrupole in its cryostat

    CERN Multimedia

    1977-01-01

    This view shows the cold mass of the prototype ISR Superconducting Quadrupole suspended to the outer vacuum tank by means of titanium alloy rods.The heat shield wrapped with superinsulation can also be seen. See also photo 7702690X.

  2. PRINCIPLE OF SKEW QUADRUPOLE MODULATION TO MEASURE BETATRON COUPLING.

    Energy Technology Data Exchange (ETDEWEB)

    LUO.Y.PILAT,F.ROSER,T.ET AL.

    2004-07-05

    The measurement of the residual betatron coupling via skew quadrupole modulation is a new diagnostics technique that has been developed and tested at the Relativistic Heavy Ion Collider (RHIC) as a very promising method for the linear decoupling on the ramp. By modulating the strengths of different skew quadrupole families the two eigentunes are precisely measured with the phase lock loop system. The projections of the residual coupling coefficient onto the skew quadrupole coupling modulation directions are determined. The residual linear coupling could be corrected according to the measurement. An analytical solution for skew quadrupole modulation based on Hamiltonian perturbation approximation is given, and simulation code using smooth accelerator model is also developed. Some issues concerning the practical applications of this technique are discussed.

  3. System for optical sorting of microscopic objects

    DEFF Research Database (Denmark)

    2014-01-01

    The present invention relates to a system for optical sorting of microscopic objects and corresponding method. An optical detection system (52) is capable of determining the positions of said first and/or said second objects. One or more force transfer units (200, 205, 210, 215) are placed...

  4. Economics of Grading and Sorting Pallet Parts

    Science.gov (United States)

    Daniel L. Schmoldt; John A. McLeod; Philip A. Araman

    1993-01-01

    Before trying to develop an automated inspection system for pallet part grading we analyzed the economics of such a system. Our results suggest that higher quality pallets produced by grading and sorting pallet parts would be attractive to both manufacturers and their customers, who would have to pay increased prices for higher quality pallets. Reductions in cost-per-...

  5. Matlab Code for Sorted Real Schur Forms

    NARCIS (Netherlands)

    Brandts, J.H.

    2001-01-01

    In Matlab, there exists a standard command to generate a real Schur form, and another command transforms a real Schur form into a complex one. In Golub and Van Loan (1996), a Matlab-like routine is sketched that sorts a complex Schur form: given a target value ? in the complex plane, the diagonal el

  6. Wavelet adaptation for automatic voice disorders sorting.

    Science.gov (United States)

    Erfanian Saeedi, Nafise; Almasganj, Farshad

    2013-07-01

    Early diagnosis of voice disorders and abnormalities by means of digital speech processing is a subject of interest for many researchers. Various methods are introduced in the literature, some of which are able to extensively discriminate pathological voices from normal ones. Voice disorders sorting, on the other hand, has received less attention due to the complexity of the problem. Although, previous publications show satisfactory results in classifying one type of disordered voice from normal cases, or two different types of abnormalities from each other, no comprehensive approach for automatic sorting of vocal abnormalities has been offered yet. In this paper, a solution for this problem is suggested. We create a powerful wavelet feature extraction approach, in which, instead of standard wavelets, adaptive wavelets are generated and applied to the voice signals. Orthogonal wavelets are parameterized via lattice structure and then, the optimal parameters are investigated through an iterative process, using the genetic algorithm (GA). GA is guided by the classifier results. Based on the generated wavelet, a wavelet-filterbank is constructed and the voice signals are decomposed to compute eight energy-based features. A support vector machine (SVM) then classifies the signals using the extracted features. Experimental results show that six various types of vocal disorders: paralysis, nodules, polyps, edema, spasmodic dysphonia and keratosis are fully sorted via the proposed method. This could be a successful step toward sorting a larger number of abnormalities associated with the vocal system. Copyright © 2013 Elsevier Ltd. All rights reserved.

  7. Credit Scores, Race, and Residential Sorting

    Science.gov (United States)

    Nelson, Ashlyn Aiko

    2010-01-01

    Credit scores have a profound impact on home purchasing power and mortgage pricing, yet little is known about how credit scores influence households' residential location decisions. This study estimates the effects of credit scores on residential sorting behavior using a novel mortgage industry data set combining household demographic, credit, and…

  8. Credit Scores, Race, and Residential Sorting

    Science.gov (United States)

    Nelson, Ashlyn Aiko

    2010-01-01

    Credit scores have a profound impact on home purchasing power and mortgage pricing, yet little is known about how credit scores influence households' residential location decisions. This study estimates the effects of credit scores on residential sorting behavior using a novel mortgage industry data set combining household demographic, credit, and…

  9. Integration through a Card-Sort Activity

    Science.gov (United States)

    Green, Kris; Ricca, Bernard P.

    2015-01-01

    Learning to compute integrals via the various techniques of integration (e.g., integration by parts, partial fractions, etc.) is difficult for many students. Here, we look at how students in a college level Calculus II course develop the ability to categorize integrals and the difficulties they encounter using a card sort-resort activity. Analysis…

  10. Integration through a Card-Sort Activity

    Science.gov (United States)

    Green, Kris; Ricca, Bernard P.

    2015-01-01

    Learning to compute integrals via the various techniques of integration (e.g., integration by parts, partial fractions, etc.) is difficult for many students. Here, we look at how students in a college level Calculus II course develop the ability to categorize integrals and the difficulties they encounter using a card sort-resort activity. Analysis…

  11. Irregular dunes, sediment sorting, and river morphodynamics

    NARCIS (Netherlands)

    Blom, Astrid; Weerts, H.J.T.; Ritsema, I.L; van Os, A.G.

    2006-01-01

    This research project focuses on modelling the large-scale morphodynamics of low-slope rivers dominated by mixed sediment, such as the Dutch part of the Rhine River. Usually we simply neglect the effects of sorting and variability in dune dimensions on the large-scale morphodynamics. This paper

  12. Sorting cells by their dynamical properties

    Science.gov (United States)

    Henry, Ewan; Holm, Stefan H.; Zhang, Zunmin; Beech, Jason P.; Tegenfeldt, Jonas O.; Fedosov, Dmitry A.; Gompper, Gerhard

    2016-10-01

    Recent advances in cell sorting aim at the development of novel methods that are sensitive to various mechanical properties of cells. Microfluidic technologies have a great potential for cell sorting; however, the design of many micro-devices is based on theories developed for rigid spherical particles with size as a separation parameter. Clearly, most bioparticles are non-spherical and deformable and therefore exhibit a much more intricate behavior in fluid flow than rigid spheres. Here, we demonstrate the use of cells’ mechanical and dynamical properties as biomarkers for separation by employing a combination of mesoscale hydrodynamic simulations and microfluidic experiments. The dynamic behavior of red blood cells (RBCs) within deterministic lateral displacement (DLD) devices is investigated for different device geometries and viscosity contrasts between the intra-cellular fluid and suspending medium. We find that the viscosity contrast and associated cell dynamics clearly determine the RBC trajectory through a DLD device. Simulation results compare well to experiments and provide new insights into the physical mechanisms which govern the sorting of non-spherical and deformable cells in DLD devices. Finally, we discuss the implications of cell dynamics for sorting schemes based on properties other than cell size, such as mechanics and morphology.

  13. MAGNET

    CERN Multimedia

    B. Curé

    2012-01-01

      The magnet was energised at the beginning of March 2012 at a low current to check all the MSS safety chains. Then the magnet was ramped up to 3.8 T on 6 March 2012. Unfortunately two days later an unintentional switch OFF of the power converter caused a slow dump. This was due to a misunderstanding of the CCC (CERN Control Centre) concerning the procedure to apply for the CMS converter control according to the beam-mode status at that time. Following this event, the third one since 2009, a discussion was initiated to define possible improvement, not only on software and procedures in the CCC, but also to evaluate the possibility to upgrade the CMS hardware to prevent such discharge from occurring because of incorrect procedure implementations. The magnet operation itself was smooth, and no power cuts took place. As a result, the number of magnetic cycles was reduced to the minimum, with only two full magnetic cycles from 0 T to 3.8 T. Nevertheless the magnet suffered four stops of the cryogeni...

  14. MAGNET

    CERN Multimedia

    Benoit Curé

    2010-01-01

    Operation of the magnet has gone quite smoothly during the first half of this year. The magnet has been at 4.5K for the full period since January. There was an unplanned short stop due to the CERN-wide power outage on May 28th, which caused a slow dump of the magnet. Since this occurred just before a planned technical stop of the LHC, during which access in the experimental cavern was authorized, it was decided to leave the magnet OFF until 2nd June, when magnet was ramped up again to 3.8T. The magnet system experienced a fault also resulting in a slow dump on April 14th. This was triggered by a thermostat on a filter choke in the 20kA DC power converter. The threshold of this thermostat is 65°C. However, no variation in the water-cooling flow rate or temperature was observed. Vibration may have been the root cause of the fault. All the thermostats have been checked, together with the cables, connectors and the read out card. The tightening of the inductance fixations has also been checked. More tem...

  15. MAGNET

    CERN Multimedia

    B. Curé

    2012-01-01

      Following the unexpected magnet stops last August due to sequences of unfortunate events on the services and cryogenics [see CMS internal report], a few more events and initiatives again disrupted the magnet operation. All the magnet parameters stayed at their nominal values during this period without any fault or alarm on the magnet control and safety systems. The magnet was stopped for the September technical stop to allow interventions in the experimental cavern on the detector services. On 1 October, to prepare the transfer of the liquid nitrogen tank on its new location, several control cables had to be removed. One cable was cut mistakenly, causing a digital input card to switch off, resulting in a cold-box (CB) stop. This tank is used for the pre-cooling of the magnet from room temperature down to 80 K, and for this reason it is controlled through the cryogenics control system. Since the connection of the CB was only allowed for a field below 2 T to avoid the risk of triggering a fast d...

  16. 免疫磁珠法分离膀胱癌CD133+细胞及生物学行为研究%Isolation of CD133 positive bladder cancer cells with magnetic cell sorting system and research on the biological characteristics

    Institute of Scientific and Technical Information of China (English)

    李法平; 陈帅奇; 王艳波; 郭辉; 刘二鹏; 侯宇川

    2014-01-01

    目的 探讨免疫磁珠法分离膀胱癌5637细胞株中CD133+细胞的方法,观察CD133阳性、阴性细胞间生物学行为的差异.方法 采用免疫磁珠法分选出膀胱癌5637细胞株中CD133+细胞,流式细胞仪检测分选纯度,通过噻唑蓝(MTT)实验、平板克隆形成实验、细胞划痕实验、分化能力检测研究其生物学行为.结果 流式细胞仪检测CD133+细胞在膀胱癌5637细胞中比例为1.45%,经免疫磁珠法分选所得CD133+细胞比例为93.45%;CD133+细胞的增殖、迁移能力明显强于CD133-、未分选的肿瘤细胞(P<0.05);平板克隆形成实验结果示CD133+组[(89.333±4.530)%]细胞克隆形成率明显高于CD133-组[(22.667±4.041)%,P<0.05].流式细胞仪检测CD133+细胞培养2d后其纯度降至48.19%,4d后其纯度与分选前无明显差异.结论 免疫磁珠分选技术可高效快捷获得CD133+细胞,CD133+细胞具有自我更新、迁徙、生成其他表型肿瘤细胞等干细胞样特性.%Objective To isolate CD133 positive cell from bladder cancer cell line 5637 with magnetic cell sorting system (MACS) and to study the different biological characteristics of CD133+ and CD133 cells.Methods Flow cytometry was used to determine the proportion of CD133 + cells sorted by magnetic-activated cell sorting in the bladder cancer cell line 5637.The biological characteristics of CD133 + and CD133-cells was studied by methyl thiazol tetrazolium (MTT) assay,Flat colony formation,Wound healing assay and differentiation ability.Results The proportion of CD133 + cells in the bladder cancer cell line 5637 was 1.45%,which was determined by flow cytometry.CD133 + cells purified by MACS were in a considerable purity of 93.42%.The proliferation and migration capacity of CD133 + cells display stronger than that of CD133-cells and non-separated tumor cells (P <0.05).The formation rate of colony sphere in CD133+ group [(89.333 ± 4.530)%] was higher than that in CD133-group

  17. Relaxation of quadrupole orientation in an optically pumped alkali vapour

    Energy Technology Data Exchange (ETDEWEB)

    Bernabeu, E.; Tornos, J.

    1985-04-01

    The relaxation of quadrupole orientation (alignment) in an optically pumped alkali vapour is theoretically studied by taking into account the relaxation processes by alkali-buffer gas, alkali-alkali with spin exchange and alkali-cell wall (diffusion process) collisions. The relaxation transients of the quadrupole orientation are obtained by introducing a first-order weak-pumping approximation (intermediate pumping) less restrictive than the usually considered (zeroth order) one.

  18. Quadrupole collectivity in {sup 128}Cd

    Energy Technology Data Exchange (ETDEWEB)

    Boenig, Esther Sabine

    2014-07-07

    The regions around shell closures, especially around doubly magic nuclei, are of major interest in nuclear structure physics, as they provide a perfect test for nuclear structure theory. The neutron-rich Cd isotopes in the region of {sup 132}Sn are only two protons away from the shell closure at Z=50 and in close proximity to the N=82 magic number. Nevertheless they show an irregular behaviour regarding the excitation energy of the first excited 2{sup +} state. This is not reproduced by shell model calculations, which is astonishing due to the proximity of the shell closures. In order to shed light on the much discussed region around doubly magic {sup 132}Sn, a Coulomb excitation experiment of {sup 128}Cd has been performed at REX-ISOLDE, CERN. The reduced transition strength B(E2;0{sup +}{sub gs} → 2{sup +}{sub 1}), which is a measure of collectivity, and the spectroscopic quadrupole moment Q{sub s}(2{sup +}{sub 1}) as a measure of deformation could be determined for the first time. The results are shown as the continuation of already measured neutron-rich Cd isotopes and are compared to both beyond mean field and shell model calculations, which give different predictions for these observables.

  19. LHC Magnet test failure

    CERN Multimedia

    2007-01-01

    "On Tueday, March 22, a Fermilab-built quadrupole magnet, one of an "inner triplet" of three focusing magnets, failed a high-pressure test at Point 5 in the tunnel of the LHC accelerator at CERN. Since Tuesday, teams at CERN and Fermilab have worked closely together to address the problem and have identified the cause of the failure. Now they are at work on a solution.:" (1 page)

  20. Development of a Prototype Automated Sorting System for Plastic Recycling

    Directory of Open Access Journals (Sweden)

    D. A. Wahab

    2006-01-01

    Full Text Available Automated sorting for plastic recyclables has been seen as the way forward in the plastic recycling industry. Automated sorting provides significant improvements in terms of efficiency and consistency in the sorting process. In the case of macro sorting, which is the most common type of automated sorting, efficiency is determined by the mechanical details of the material handling system as well as the detection system. This paper provides a review on the state of-the-art technologies that have been deployed by some of the recycling facilities abroad. The design and development of a cost effective prototype automated system for sorting plastic recyclables is proposed and discussed.

  1. Multiple pathways for vacuolar sorting of yeast proteinase A

    DEFF Research Database (Denmark)

    Westphal, V; Marcusson, E G; Winther, Jakob R.

    1996-01-01

    The sorting of the yeast proteases proteinase A and carboxypeptidase Y to the vacuole is a saturable, receptor-mediated process. Information sufficient for vacuolar sorting of the normally secreted protein invertase has in fusion constructs previously been found to reside in the propeptide...... of proteinase A. We found that sorting of such a hybrid protein is dependent on the vacuolar protein-sorting receptor Vps10p. This was unexpected, as strains disrupted for VPS10 sort more than 85% of the proteinase A to the vacuole. Consistent with a role for Vps10p in sorting of proteinase A, we found that 1...

  2. MAGNET

    CERN Multimedia

    B. Curé

    2012-01-01

      The magnet and its sub-systems were stopped at the beginning of the winter shutdown on 8th December 2011. The magnet was left without cooling during the cryogenics maintenance until 17th January 2012, when the cryoplant operation resumed. The magnet temperature reached 93 K. The vacuum pumping was maintained during this period. During this shutdown, the yearly maintenance was performed on the cryogenics, the vacuum pumps, the magnet control and safety systems, and the power converter and discharge lines. Several preventive actions led to the replacement of the electrovalve command coils, and the 20A DC power supplies of the magnet control system. The filters were cleaned on the demineralised water circuits. The oil of the diffusion pumps was changed. On the cryogenics, warm nitrogen at 343 K was circulated in the cold box to regenerate the filters and the heat exchangers. The coalescing filters have been replaced at the inlet of both the turbines and the lubricant trapping unit. The active cha...

  3. MAGNET

    CERN Multimedia

    Benoit Curé

    2010-01-01

    The magnet was successfully operated at the end of the year 2009 despite some technical problems on the cryogenics. The magnet was ramped up to 3.8 T at the end of November until December 16th when the shutdown started. The magnet operation met a few unexpected stops. The field was reduced to 3.5 T for about 5 hours on December 3rd due to a faulty pressure sensor on the helium compressor. The following day the CERN CCC stopped unintentionally the power converters of the LHC and the experiments, triggering a ramp down that was stopped at 2.7 T. The magnet was back at 3.8 T about 6 hours after CCC sent the CERN-wide command. Three days later, a slow dump was triggered due to a stop of the pump feeding the power converter water-cooling circuit, during an intervention on the water-cooling plant done after several disturbances on the electrical distribution network. The magnet was back at 3.8 T in the evening the same day. On December 10th a break occurred in one turbine of the cold box producing the liquid ...

  4. MAGNET

    CERN Multimedia

    B. Curé

    2013-01-01

      The magnet was operated without any problem until the end of the LHC run in February 2013, apart from a CERN-wide power glitch on 10 January 2013 that affected the CMS refrigerator, causing a ramp down to 2 T in order to reconnect the coldbox. Another CERN-wide power glitch on 15 January 2013 didn’t affect the magnet subsystems, the cryoplant or the power converter. At the end of the magnet run, the reconnection of the coldbox at 2.5 T was tested. The process will be updated, in particular the parameters of some PID valve controllers. The helium flow of the current leads was reduced but only for a few seconds. The exercise will be repeated with the revised parameters to validate the automatic reconnection process of the coldbox. During LS1, the water-cooling services will be reduced and many interventions are planned on the electrical services. Therefore, the magnet cryogenics and subsystems will be stopped for several months, and the magnet cannot be kept cold. In order to avoid unc...

  5. MAGNET

    CERN Multimedia

    B. Curé

    2011-01-01

    The CMS magnet has been running steadily and smoothly since the summer, with no detected flaw. The magnet instrumentation is entirely operational and all the parameters are at their nominal values. Three power cuts on the electrical network affected the magnet run in the past five months, with no impact on the data-taking as the accelerator was also affected at the same time. On 22nd June, a thunderstorm caused a power glitch on the service electrical network. The primary water cooling at Point 5 was stopped. Despite a quick restart of the water cooling, the inlet temperature of the demineralised water on the busbar cooling circuit increased by 5 °C, up to 23.3 °C. It was kept below the threshold of 27 °C by switching off other cooling circuits to avoid the trigger of a slow dump of the magnet. The cold box of the cryogenics also stopped. Part of the spare liquid helium volume was used to maintain the cooling of the magnet at 4.5 K. The operators of the cryogenics quickly restarted ...

  6. PhySortR: a fast, flexible tool for sorting phylogenetic trees in R

    Directory of Open Access Journals (Sweden)

    Timothy G. Stephens

    2016-05-01

    Full Text Available A frequent bottleneck in interpreting phylogenomic output is the need to screen often thousands of trees for features of interest, particularly robust clades of specific taxa, as evidence of monophyletic relationship and/or reticulated evolution. Here we present PhySortR, a fast, flexible R package for classifying phylogenetic trees. Unlike existing utilities, PhySortR allows for identification of both exclusive and non-exclusive clades uniting the target taxa based on tip labels (i.e., leaves on a tree, with customisable options to assess clades within the context of the whole tree. Using simulated and empirical datasets, we demonstrate the potential and scalability of PhySortR in analysis of thousands of phylogenetic trees without a priori assumption of tree-rooting, and in yielding readily interpretable trees that unambiguously satisfy the query. PhySortR is a command-line tool that is freely available and easily automatable.

  7. Performance of HQ02, an optimized version of the 120 mm $Nb_3Sn$ LARP quadrupole

    CERN Document Server

    Chlachidze, G; Anerella, M; Borgnolutti, F; Bossert, R; Caspi, S; Cheng, D W; Dietderich, D; Felice, H; Ferracin, P; Ghosh, A; Godeke, A; Hafalia A R; Marchevsky, M; Orris, D; Roy, P K; Sabbi, G L; Salmi, T; Schmalzle, J; Sylvester, C; Tartaglia, M; Tompkins, J; Wanderer, P; Wang, X R; Zlobin, A V

    2014-01-01

    In preparation for the high luminosity upgrade of the Large Hadron Collider (LHC), the LHC Accelerator Research Program (LARP) is developing a new generation of large aperture high-field quadrupoles based on Nb3Sn technology. One meter long and 120 mm diameter HQ quadrupoles are currently produced as a step toward the eventual aperture of 150 mm. Tests of the first series of HQ coils revealed the necessity for further optimization of the coil design and fabrication process. A new model (HQ02) has been fabricated with several design modifications, including a reduction of the cable size and an improved insulation scheme. Coils in this magnet are made of a cored cable using 0.778 mm diameter Nb3Sn strands of RRP 108/127 sub-element design. The HQ02 magnet has been fabricated at LBNL and BNL, and then tested at Fermilab. This paper summarizes the performance of HQ02 at 4.5 K and 1.9 K temperatures.

  8. Stabilization and Fine Positioning to the Nanometre Level of the CLIC Main Beam Quadrupoles

    CERN Document Server

    Artoos, K; Fernandez Carmona, P; Guinchard, M; Hauviller, C; Janssens, S; Kuzmin, A; Lackner, F; Leuxe, R; Slaathaug, A

    2010-01-01

    The CLIC main beam quadrupoles need to be stabilized to 1.5 nm integrated R.M.S. displacement at 1 Hz. The choice was made to apply active stabilization with piezoelectric actuators in a rigid support with flexural guides. The advantages of this choice are the robustness against external forces and the possibility to make fast incremental nanometre positioning of the magnet with the same actuators. The study and feasibility demonstration is made in several steps from a single degree of freedom system (s.d.o.f.) with a small mass, a s.d.o.f. with a large mass, leading to the demonstration including the smallest (type 1) and largest (type 4) CLIC main beam quadrupoles. The paper discusses the choices of the position and orientation of the actuators and the tailored rigidities of the flexural hinges in the multi degree of freedom system, and the corresponding MIMO control system. The compatibility with the magnet support and micrometre alignment system is essential. The status of the study and performed tests wi...

  9. MAGNETS

    Science.gov (United States)

    Hofacker, H.B.

    1958-09-23

    This patent relates to nmgnets used in a calutron and more particularly to means fur clamping an assembly of magnet coils and coil spacers into tightly assembled relation in a fluid-tight vessel. The magnet comprises windings made up of an assembly of alternate pan-cake type coils and spacers disposed in a fluid-tight vessel. At one end of the tank a plurality of clamping strips are held firmly against the assembly by adjustable bolts extending through the adjacent wall. The foregoing arrangement permits taking up any looseness which may develop in the assembly of coils and spacers.

  10. MAGNET

    CERN Multimedia

    B. Curé

    2011-01-01

    The magnet ran smoothly in the last few months until a fast dump occurred on 9th May 2011. Fortunately, this occurred in the afternoon of the first day of the technical stop. The fast dump was due to a valve position controller that caused the sudden closure of a valve. This valve is used to regulate the helium flow on one of the two current leads, which electrically connects the coil at 4.5 K to the busbars at room temperature. With no helium flow on the lead, the voltage drop and the temperatures across the leads increase up to the defined thresholds, triggering a fast dump through the Magnet Safety System (MSS). The automatic reaction triggered by the MSS worked properly. The helium release was limited as the pressure rise was just at the limit of the safety valve opening pressure. The average temperature of the magnet reached 72 K. It took four days to recover the temperature and refill the helium volumes. The faulty valve controller was replaced by a spare one before the magnet ramp-up resumed....

  11. 磁激活细胞分选术联合混合抗体提高模拟恶性腹水中游离癌细胞检出效率的分析%Magnetic activated cell sorting combined with a panel of monoclonal antibodies in detecting free cancer cells in analogue malignant ascites

    Institute of Scientific and Technical Information of China (English)

    王晓蕾; 陈锡美; 黄志刚; 王韶英

    2008-01-01

    背景磁激活细胞分选术(magnetic activated cell sorting,MACS)是一种新的免疫磁性分离技术.其原理是基于抗体对抗原的特异性识别,将50 nm磁性微珠直接或者间接耦联在抗体上,与有相应抗原表达的细胞相连,在高强度、高梯度磁场中达到细胞磁性分离的目的.该法具有分离纯度和回收率均较高的优势,也能分离出体液中存在的少量肿瘤细胞.目的评价MACS联合一组肿瘤细胞标志物的方法对提高模拟恶性腹水中游离癌细胞检出效率的作用.方法 选择5种与恶性腹水病因有关的肿瘤细胞株作为研究对象,采用免疫荧光反应和流式细胞仪(FCM)检测上皮相关抗原(epithlial-related antigen,EpCAM)、CA125、癌胚抗原和TAG-72共4种单克隆抗体及其混合抗体在各肿瘤细胞的表达.将肿瘤细胞以不同比例掺入单个核细胞中模拟恶性腹水细胞成分,与联合单个抗体进行分选对比,观察MACS术联合混合抗体分选肿瘤细胞的效率.结果 FCM结果表明,混合抗体在5种肿瘤细胞的阳性表达率均高于4种抗体单独反应的阳性率.MACS术联合混合抗体检出模拟恶性腹水中肿瘤细胞的得率比联合单个抗体的得率要高,其中以2种胃癌细胞和结肠癌细胞的平均得率提高较多(分别为69.18%±20.84%比45.23%±11.54%、78.75%±15.42%比59.73%±16.64%和85.63%±12.30%比76.88%±8.65%),卵巢癌细胞次之(32.49%±3.58%比31.79%±4.82%),肝癌细胞最少(11.78%±0.43%比7.16%±0.46%).结论 与联合单个抗体进行分选相比,应用MACS术联合一组混合抗体的方法可有效提高恶性腹水中游离癌细胞的检出效率,尤其对胃肠道肿瘤所致的恶性腹水有潜在的临床应用价值.%Background Magnetic activated cell sorting(MACS)is a new immunomagnetic separation technique.It's principle is based on the specialized recognition between the antibody and antigen.When directed or indirected coupled with the 50 nm

  12. Colour based sorting station with Matlab simulation

    Directory of Open Access Journals (Sweden)

    Constantin Victor

    2017-01-01

    Full Text Available The paper presents the design process and manufacturing elements of a colour-based sorting station. The system is comprised of a gravitational storage, which also contains the colour sensor. Parts are extracted using a linear pneumatic motor and are fed onto an electrically driven conveyor belt. Extraction of the parts is done at 4 points, using two pneumatic motors and a geared DC motor, while the 4th position is at the end of the belt. The mechanical parts of the system are manufactured using 3D printer technology, allowing for easy modification and adaption to the geometry of different parts. The paper shows all of the stages needed to design, optimize, test and implement the proposed solution. System optimization was performed using a graphical Matlab interface which also allows for sorting algorithm optimization.

  13. Machine-vision based optofluidic cell sorting

    DEFF Research Database (Denmark)

    Glückstad, Jesper; Bañas, Andrew

    In contemporary life science there is an increasing emphasis on sorting rare disease-indicating cells within small dilute quantities such as in the confines of optofluidic lab-on-chip devices. Our approach to this is based on the use of optical forces to isolate red blood cells detected by advanc...... the available light and creating 2D or 3D beam distributions aimed at the positions of the detected cells. Furthermore, the beam shaping freedom provided by GPC can allow optimizations in the beam’s propagation and its interaction with the laser catapulted and sorted cells....... machine vision1. This approach is gentler, less invasive and more economical compared to conventional FACS-systems. As cells are less responsive to plastic or glass objects commonly used in the optical manipulation literature2, and since laser safety would be an issue in clinical use, we develop efficient...

  14. A mower detector to judge soil sorting

    Energy Technology Data Exchange (ETDEWEB)

    Bramlitt, E.T.; Johnson, N.R. [Thermo Nuclear Services, Inc., Albuquerque, NM (United States)

    1995-12-31

    Thermo Nuclear Services (TNS) has developed a mower detector as an inexpensive and fast means for deciding potential value of soil sorting for cleanup. It is a shielded detector box on wheels pushed over the ground (as a person mows grass) at 30 ft/min with gamma-ray counts recorded every 0.25 sec. It mirror images detection by the TNS transportable sorter system which conveys soil at 30 ft/min and toggles a gate to send soil on separate paths based on counts. The mower detector shows if contamination is variable and suitable for sorting, and by unique calibration sources, it indicates detection sensitivity. The mower detector has been used to characterize some soil at Department of Energy sites in New Jersey and South Carolina.

  15. Efficient sorting using registers and caches

    DEFF Research Database (Denmark)

    Wickremesinghe, Rajiv; Arge, Lars Allan; Chase, Jeffrey S.;

    2002-01-01

    Modern computer systems have increasingly complex memory systems. Common machine models for algorithm analysis do not reflect many of the features of these systems, e.g., large register sets, lockup-free caches, cache hierarchies, associativity, cache line fetching, and streaming behavior...... on sorting performance. We introduce a new cache-conscious sorting algorithm, R-MERGE, which achieves better performance in practice over algorithms that are superior in the theoretical models. R-MERGE is designed to minimize memory stall cycles rather than cache misses by considering features common to many....... Inadequate models lead to poor algorithmic choices and an incomplete understanding of algorithm behavior on real machines.A key step toward developing better models is to quantify the performance effects of features not reflected in the models. This paper explores the effect of memory system features...

  16. Sorting Network for Reversible Logic Synthesis

    CERN Document Server

    Islam, Md Saiful; Mahmud, Abdullah Al; karim, Muhammad Rezaul

    2010-01-01

    In this paper, we have introduced an algorithm to implement a sorting network for reversible logic synthesis based on swapping bit strings. The algorithm first constructs a network in terms of n*n Toffoli gates read from left to right. The number of gates in the circuit produced by our algorithm is then reduced by template matching and removing useless gates from the network. We have also compared the efficiency of the proposed method with the existing ones.

  17. Final Development and test preparation of the first 3.7m long Nb3Sn quadrupole by LARP

    Energy Technology Data Exchange (ETDEWEB)

    Ambrosio, G.; Andreev, N.; Anerella, M.; Barzi, E.; Bingham, B.; Bocian, D.; Bordini, B.; Bossert, R.; Bottura, L.; Caspi, S.; Chlachidize, G.; /Fermilab /Brookhaven /LBL, Berkeley /CERN

    2009-10-01

    The test of the first LARP (LHC Accelerator Research Program) Long Quadrupole is a significant milestone toward the development of Nb{sub 3}Sn quadrupoles for LHC (Large Hadron Collider) Luminosity Upgrades. These 3.7-m long magnets, scaled from the 1-m long Technological Quadrupoles, are used to develop our capabilities to fabricate and assemble Nb{sub 3}Sn coils and structures with lengths comparable to accelerator magnet dimensions. The long quadruples have a target gradient of 200 T/m in a 90-mm aperture. Pre-stress and support are provided by an Al-shell-based structure pre-loaded using bladders and keys. The coils were fabricated at BNL and FNAL, the shell-based structure was designed and assembled at LBNL, the test is performed at FNAL. In this paper we present the final steps of the development of the first model (LQS01), several upgrades to the test facility, the test results of witness cables, and the short sample limit.

  18. Evaluating Effects of Cell Sorting on Cellular Integrity

    OpenAIRE

    2014-01-01

    During the past year the Flow Cytometry Research Group has continued on its goal to establish best practice guidelines for cell sorting conditions that minimize cell stress, perturbation, or injury to the sorted cells. Towards this goal the group has followed up on an observation from our initial study that showed poor cell recovery when a clonal population of cells (Jurkat) was sorted aggressively under intentionally adverse sorting conditions (excessive pressure as well as undersized sortin...

  19. How Schwann Cells Sort Axons: New Concepts.

    Science.gov (United States)

    Feltri, M Laura; Poitelon, Yannick; Previtali, Stefano Carlo

    2016-06-01

    Peripheral nerves contain large myelinated and small unmyelinated (Remak) fibers that perform different functions. The choice to myelinate or not is dictated to Schwann cells by the axon itself, based on the amount of neuregulin I-type III exposed on its membrane. Peripheral axons are more important in determining the final myelination fate than central axons, and the implications for this difference in Schwann cells and oligodendrocytes are discussed. Interestingly, this choice is reversible during pathology, accounting for the remarkable plasticity of Schwann cells, and contributing to the regenerative potential of the peripheral nervous system. Radial sorting is the process by which Schwann cells choose larger axons to myelinate during development. This crucial morphogenetic step is a prerequisite for myelination and for differentiation of Remak fibers, and is arrested in human diseases due to mutations in genes coding for extracellular matrix and linkage molecules. In this review we will summarize progresses made in the last years by a flurry of reverse genetic experiments in mice and fish. This work revealed novel molecules that control radial sorting, and contributed unexpected ideas to our understanding of the cellular and molecular mechanisms that control radial sorting of axons.

  20. Chromosome analysis and sorting using flow cytometry.

    Science.gov (United States)

    Doležel, Jaroslav; Kubaláková, Marie; Cíhalíková, Jarmila; Suchánková, Pavla; Simková, Hana

    2011-01-01

    Chromosome analysis and sorting using flow cytometry (flow cytogenetics) is an attractive tool for fractionating plant genomes to small parts. The reduction of complexity greatly simplifies genetics and genomics in plant species with large genomes. However, as flow cytometry requires liquid suspensions of particles, the lack of suitable protocols for preparation of solutions of intact chromosomes delayed the application of flow cytogenetics in plants. This chapter outlines a high-yielding procedure for preparation of solutions of intact mitotic chromosomes from root tips of young seedlings and for their analysis using flow cytometry and sorting. Root tips accumulated at metaphase are mildly fixed with formaldehyde, and solutions of intact chromosomes are prepared by mechanical homogenization. The advantages of the present approach include the use of seedlings, which are easy to handle, and the karyological stability of root meristems, which can be induced to high degree of metaphase synchrony. Chromosomes isolated according to this protocol have well-preserved morphology, withstand shearing forces during sorting, and their DNA is intact and suitable for a range of applications.

  1. Generalized sorting profile of alluvial fans

    Science.gov (United States)

    Miller, Kimberly Litwin; Reitz, Meredith D.; Jerolmack, Douglas J.

    2014-10-01

    Alluvial rivers often exhibit self-similar gravel size distributions and abrupt gravel-sand transitions. Experiments suggest that these sorting patterns are established rapidly, but how—and how fast—this convergence occurs in the field is unknown. We examine the establishment of downstream sorting patterns in a kilometer-scale alluvial fan. The sharp transition from canyon to unconfined, channelized fan provides a well-defined boundary condition. The channel changes from deep and entrenched at the fan apex to shallow and depositional over a short distance, exhibiting nonequilibrium behavior. The resulting gravel-fining profile is not self-similar; the particle size distribution narrows until approximate equal mobility is achieved. Downfan, the gravel-sand transition appears to exhibit a self-similar form; field and laboratory data collapse when downstream distance is normalized by the location of the transition. Results suggest a generalized sorting profile for alluvial fans as a consequence of the threshold of motion and nonequilibrium channels.

  2. Lowering of the last magnet

    CERN Multimedia

    CERN Audiovisual service

    2009-01-01

    On May 4th, the 53rd and final magnet for the Sector 3-4 repairs has been lowered into the tunnel, marking the end of surface work for the direct repair of the LHC. The magnet, a short straight section (SSS) quadrupole magnet, has started its descent at 4:00pm and has been transported to Sector 3-4 and installed in position during the evening. Interview with Lucio Rossi, Deputy head of the Technology Department.

  3. Categorizing Variations of Student-Implemented Sorting Algorithms

    Science.gov (United States)

    Taherkhani, Ahmad; Korhonen, Ari; Malmi, Lauri

    2012-01-01

    In this study, we examined freshmen students' sorting algorithm implementations in data structures and algorithms' course in two phases: at the beginning of the course before the students received any instruction on sorting algorithms, and after taking a lecture on sorting algorithms. The analysis revealed that many students have insufficient…

  4. Gender Sorting across K-12 Schools in the United States

    Science.gov (United States)

    Long, Mark C.; Conger, Dylan

    2013-01-01

    This article documents evidence of nonrandom gender sorting across K-12 schools in the United States. The sorting exists among coed schools and at all grade levels, and it is highest in the secondary school grades. We observe some gender sorting across school sectors and types: for instance, males are slightly underrepresented in private schools…

  5. Automatic Color Sorting of Hardwood Edge-Glued Panel Parts

    Science.gov (United States)

    D. Earl Kline; Richard Conners; Qiang Lu; Philip A. Araman

    1997-01-01

    This paper describes an automatic color sorting system for red oak edge-glued panel parts. The color sorting system simultaneously examines both faces of a panel part and then determines which face has the "best" color, and sorts the part into one of a number of color classes at plant production speeds. Initial test results show that the system generated over...

  6. Categorizing Variations of Student-Implemented Sorting Algorithms

    Science.gov (United States)

    Taherkhani, Ahmad; Korhonen, Ari; Malmi, Lauri

    2012-01-01

    In this study, we examined freshmen students' sorting algorithm implementations in data structures and algorithms' course in two phases: at the beginning of the course before the students received any instruction on sorting algorithms, and after taking a lecture on sorting algorithms. The analysis revealed that many students have insufficient…

  7. Spontaneous structural distortion of the metallic Shastry-Sutherland system Dy B4 by quadrupole-spin-lattice coupling

    Science.gov (United States)

    Sim, Hasung; Lee, Seongsu; Hong, Kun-Pyo; Jeong, Jaehong; Zhang, J. R.; Kamiyama, T.; Adroja, D. T.; Murray, C. A.; Thompson, S. P.; Iga, F.; Ji, S.; Khomskii, D.; Park, Je-Geun

    2016-11-01

    Dy B4 has a two-dimensional Shastry-Sutherland (Sh-S) lattice with strong Ising character of the Dy ions. Despite the intrinsic frustrations, it undergoes two successive transitions: a magnetic ordering at TN=20 K and a quadrupole ordering at TQ=12.5 K . From high-resolution neutron and synchrotron x-ray powder diffraction studies, we have obtained full structural information on this material in all phases and demonstrate that structural modifications occurring at quadrupolar transition lead to the lifting of frustrations inherent in the Sh-S model. Our paper thus provides a complete experimental picture of how the intrinsic frustration of the Sh-S lattice can be lifted by the coupling to quadrupole moments. We show that two other factors, i.e., strong spin-orbit coupling and long-range Ruderman-Kittel-Kasuya-Yosida (RKKY) interaction in metallic Dy B4 , play an important role in this behavior.

  8. Polarization creation in proton-rich {sup 28}P via charge exchange reactions and measurement of its electric quadrupole moment

    Energy Technology Data Exchange (ETDEWEB)

    Matsuta, K., E-mail: matsuta@vg.phys.sci.osaka-u.ac.jp; Mihara, M. [Osaka University, Department of Physics (Japan); Zhou, D. M.; Zheng, Y. N. [CIAE (China); Nishimura, D. [Osaka University, Department of Physics (Japan); Nagatomo, T. [International Christian University (Japan); Yuan, D. Q. [CIAE (China); Momota, S. [Kochi University of Technology (Japan); Izumikawa, T. [Niigata University, RI Center (Japan); Zuo, Y.; Fan, P.; Zhu, S. Y. [CIAE (China); Ohtsubo, T. [Niigata University (Japan); Fukuda, M. [Osaka University, Department of Physics (Japan); Namiki, Y.; Nagashima, M. [Niigata University (Japan); Minamisono, T. [Fukui University of Technology (Japan); Kameda, D. [RIKEN (Japan); Sumikama, T. [Tokyo University of Science (Japan); Kitagawa, A. [NIRS (Japan); and others

    2010-06-15

    The degrees of polarization of proton rich nucleus {sup 28}P produced in charge exchange reactions {sup 28}Si + {sup 9}Be {yields} {sup 28}P + X, and {sup 28}Si + {sup 1}H {yields} {sup 28}P + X have been observed at 100A MeV. Utilizing thus obtained polarized nuclei, the magnetic moment of {sup 28}P was remeasured, and vertical bar {mu}({sup 28}P) vertical bar = 0.3115 (34) {mu}{sub N} was obtained. {beta}-nuclear quadrupole resonance ({beta}-NQR) of {sup 28}P implanted in {alpha}-Al{sub 2}O{sub 3} have been observed for the first time, in order to measure the electric quadrupole moment of this nucleus.

  9. 免疫磁珠法在分离纯化外周血CD4+和CD8+T淋巴细胞亚群中的应用%APPLICATION OF MAGNETIC ACTIVARED CELL SORTING FOR SEPARATION AND PURIFICATION OF CD4+ T CELL AND CD8+T CELL SUBPOPULATIONS OF PERIPHERAL BLOOD

    Institute of Scientific and Technical Information of China (English)

    莫雪安; 周礼圆; 秦超; 张德敏; 赵伟金

    2012-01-01

    目的:探讨免疫磁珠法(MiniMACS)在分离纯化外周血CD4+和CD8+T淋巴细胞亚群中的应用.方法:应用密度梯度离心法分离外周血单个核细胞(Peripheral blood mononucleate cells,PBMC),采用MiniMACS分别分离和纯化39例标本外周血PBMC中的CD4+T淋巴细胞和CD8+T淋巴细胞,并经流式细胞仪分析细胞纯度和台盼蓝染色的方法对细胞活力进行评估.结果:MiniMACS分离外周血CD4+T淋巴细胞前、后细胞纯度分别为(37.38±5.74)%、(97.75±1.03)%(P<0.001),CD8+T淋巴细胞分离纯化前后细胞纯度分别为(20.11±6.83)%、(96.85±1.86)%(P<0.001);外周血分离前PBMC细胞活力为(97.66±2.73)%,纯化为CD4+T淋巴细胞和CD8+T淋巴细胞后细胞活力分别为(97.44±3.08)%、(98.05±2.92)%(P>0.05).结论:MiniMACS可以高度富集CD4+T淋巴细胞和CD8+T淋巴细胞且不改变细胞的活力.%To evaluate the separation and purification of T lymphocyte subsets by immunomag-netic beads. Methods: Peripheral blood mononucleate cells (PBMC) were isolated using lymphocytes separation medium and desity gradient centrifugal action. CD4+T and CD8+T lymphocytes were isolated and purified from PBMC by magnetic activated cell sorting (MiniMACS). The purity and activity of CD4+T and CD8+T cells were measured using flow cytometry, trypan-blue dye exclusion test, etc. Results: The results showed that the percentage of CD4+T cells before and after the purification was (37. 38 + 5. 74)% and (97. 75 + 1. 03)% ( P <0. 001) ; the percentage of CD8+T cells before and after the purification was (20. 11 + 6. 83) % and (96. 85 + 1. 86) % ( P <0. 001) , resprectively; and the cell ability was not affected by purification procedure ( P <0. 05). Conclusion: MiniMACS can sort out effectively CD4 + T and CD8+ T cell subpopulations of peripheral blood and does not affect the cell vitality.

  10. MAGNET

    CERN Multimedia

    B. Curé

    2013-01-01

    The magnet is fully stopped and at room temperature. The maintenance works and consolidation activities on the magnet sub-systems are progressing. To consolidate the cryogenic installation, two redundant helium compressors will be installed as ‘hot spares’, to avoid the risk of a magnet downtime in case of a major failure of a compressor unit during operation. The screw compressors, their motors, the mechanical couplings and the concrete blocks are already available and stored at P5. The metallic structure used to access the existing compressors in SH5 will be modified to allow the installation of the two redundant ones. The plan is to finish the installation and commissioning of the hot spare compressors before the summer 2014. In the meantime, a bypass on the high-pressure helium piping will be installed for the connection of a helium drier unit later during the Long Shutdown 1, keeping this installation out of the schedule critical path. A proposal is now being prepared for the con...

  11. MAGNET

    CERN Multimedia

    B. Curé

    MAGNET During the winter shutdown, the magnet subsystems went through a full maintenance. The magnet was successfully warmed up to room temperature beginning of December 2008. The vacuum was broken later on by injecting nitrogen at a pressure just above one atmosphere inside the vacuum tank. This was necessary both to prevent any accidental humidity ingress, and to allow for a modification of the vacuum gauges on the vacuum tank and maintenance of the diffusion pumps. The vacuum gauges had to be changed, because of erratic variations on the measurements, causing spurious alarms. The new type of vacuum gauges has been used in similar conditions on the other LHC experiments and without problems. They are shielded against the stray field. The lubricants of the primary and diffusion pumps have been changed. Several minor modifications were also carried out on the equipment in the service cavern, with the aim to ease the maintenance and to allow possible intervention during operation. Spare sensors have been bough...

  12. MAGNET

    CERN Multimedia

    Benoit Curé

    2010-01-01

    The magnet worked very well at 3.8 T as expected, despite a technical issue that manifested twice in the cryogenics since June. All the other magnet sub-systems worked without flaw. The issue in the cryogenics was with the cold box: it could be observed that the cold box was getting progressively blocked, due to some residual humidity and air accumulating in the first thermal exchanger and in the adsorber at 65 K. This was later confirmed by the analysis during the regeneration phases. An increase in the temperature difference between the helium inlet and outlet across the heat exchanger and a pressure drop increase on the filter of the adsorber were observed. The consequence was a reduction of the helium flow, first compensated by the automatic opening of the regulation valves. But once they were fully opened, the flow and refrigeration power reduced as a consequence. In such a situation, the liquid helium level in the helium Dewar decreased, eventually causing a ramp down of the magnet current and a field...

  13. MAGNET

    CERN Multimedia

    Benoit Curé.

    The magnet operation restarted end of June this year. Quick routine checks of the magnet sub-systems were performed at low current before starting the ramps up to higher field. It appeared clearly that the end of the field ramp down to zero was too long to be compatible with the detector commissioning and operations plans. It was decided to perform an upgrade to keep the ramp down from 3.8T to zero within 4 hours. On July 10th, when a field of 1.5T was reached, small movements were observed in the forward region support table and it was decided to fix this problem before going to higher field. At the end of July the ramps could be resumed. On July 28th, the field was at 3.8T and the summer CRAFT exercise could start. This run in August went smoothly until a general CERN wide power cut took place on August 3rd, due to an insulation fault on the high voltage network outside point 5. It affected the magnet powering electrical circuit, as it caused the opening of the main circuit breakers, resulting in a fast du...

  14. Nuclear Quadrupole Resonance Study of Potassium - - Chloride.

    Science.gov (United States)

    Ramia, Maximo Elias

    Fast Fourier transform nuclear quadrupole resonance (NQR) was used to study the cubic antifluorite crystal potassium hexacloro-osmate, K(,2)OsCl(,6). The study of the ('35)Cl and ('37)Cl resonances were performed on three samples of K(,2)OsCl(,6), a powder sample, a powder sample recrystallized from D(,2)O and a single crystal sample. The studies were carried out in the temperature range 300 to 6K. A detailed study of the ('35)Cl and ('37)Cl NQR lineshapes, in the temperature range 70 to 300K, showed that the lineshapes reflect the strain fields produced by lattice dislocations and point defects. The temperature evolution of these strain fields give rise to a satellite line which previously was attributed to H('+) ion impurities present in the samples. A comprehensive study of the temperature evolution of the NQR spectrum in the vicinity of the phase transition revealed a drop of line intensity and the progressive appearance of an extra broad resonance component. Both effects are associated with the existence of precursor dynamic clusters at temperatures higher than T(,C). Qualitatively similar but quantitatively different behaviour was observed in the powder and single crystal samples. Although the precursor clusters are an intrinsic property of the phrase transition, their detailed dynamics is sample independent. A NQR study of the tetragonal phase showed that at the lowest temperature the ratio of line intensities is 2:1. The phase shift effect previously observed in the tetragonal phase of K(,2)ReCl(,6) was also observed in K(,2)OsCl(,6). The effect has been explained as an experimental artifact introduced by the truncation of the FID due to the spectrometer dead time. Spin-lattice relaxation measurements in the cubic phase show two component relaxation in the vicinity of T(,C). The behaviour is quantitatively different in the powder and single crystal samples. The short relaxation time is associated with dynamic clusters. Spin-lattice relaxation time

  15. The effect of cooling water on magnet vibrations

    CERN Document Server

    Redaelli, S; Coosemans, Williame; Schnell, Wolfgang

    2002-01-01

    The quadrupole magnets in the CLIC Test Facility II (CTF2) incorporate a water cooling circuit. In the frame-work of the CLIC stability study, the mechanical vibrations of the magnets were measured for different flows of cool-ing water. We present the results and compare them with simple theoretical estimates. It is shown that the vibra-tion requirements of the Compact LInear Collider (CLIC) quadrupoles with cooling water can basically be met.

  16. Drift wave launching in a linear quadrupole

    Energy Technology Data Exchange (ETDEWEB)

    Tessema, G.Y.; Elliott, J.A.; Rusbridge, M.G. (Manchester Univ. (UK). Inst. of Science and Technology)

    1989-12-01

    Drift waves have been successfully launched from flag probes in a steady-state magnetized plasma, and the launching mechanism has been identified. Non-linear interactions are observed between launched and intrinsic waves. A wide range of further experimental studies is thus made possible, of fundamental relevance to plasma confinement. (author).

  17. Cache-Aware and Cache-Oblivious Adaptive Sorting

    DEFF Research Database (Denmark)

    Brodal, Gerth Stølting; Fagerberg, Rolf; Moruz, Gabriel

    2005-01-01

    Two new adaptive sorting algorithms are introduced which perform an optimal number of comparisons with respect to the number of inversions in the input. The first algorithm is based on a new linear time reduction to (non-adaptive) sorting. The second algorithm is based on a new division protocol ...... for the GenericSort algorithm by Estivill-Castro and Wood. From both algorithms we derive I/O-optimal cache-aware and cache-oblivious adaptive sorting algorithms. These are the first I/O-optimal adaptive sorting algorithms....

  18. Advanced optimization of permanent magnet wigglers using a genetic algorithm

    Energy Technology Data Exchange (ETDEWEB)

    Hajima, Ryoichi [Univ. of Tokyo (Japan)

    1995-12-31

    In permanent magnet wigglers, magnetic imperfection of each magnet piece causes field error. This field error can be reduced or compensated by sorting magnet pieces in proper order. We showed a genetic algorithm has good property for this sorting scheme. In this paper, this optimization scheme is applied to the case of permanent magnets which have errors in the direction of field. The result shows the genetic algorithm is superior to other algorithms.

  19. Linear Quadrupole Cooling Channel for a Neutrino Factory

    CERN Document Server

    Johnstone, Carol; Makino, Kyoko

    2005-01-01

    The staging and optimization in the design of a Neutrino Factory are critically dependent on the choice and format of accelerator. Possibly the simplest, lowest-cost scenario is a nonscaling FFAG machine coupled to a linear (no bending) transverse cooling channel constructed from the simplest quadrupole lens system, a FODO cell. In such a scenario, transverse cooling demands are reduced by a factor of 4 and no longitudinal cooling is required relative to acceleration using a Recirculating Linac (RLA). Detailed simulations further show that a quadrupole-based channel cools efficiently and over a momentum range which is well-matched to FFAG acceleration. Details and cooling performance for a quadrupole channel are summarized in this work.

  20. Stochastic Models of Vesicular Sorting in Cellular Organelles

    CERN Document Server

    Vagne, Quentin

    2016-01-01

    The proper sorting of membrane components by regulated exchange between cellular organelles is crucial to intra-cellular organization. This process relies on the budding and fusion of transport vesicles, and should be strongly influenced by stochastic fluctuations considering the relatively small size of many organelles. We identify the perfect sorting of two membrane components initially mixed in a single compartment as a first passage process, and we show that the mean sorting time exhibits two distinct regimes as a function of the ratio of vesicle fusion to budding rates. Low ratio values leads to fast sorting, but results in a broad size distribution of sorted compartments dominated by small entities. High ratio values result in two well defined sorted compartments but is exponentially slow. Our results suggests an optimal balance between vesicle budding and fusion for the rapid and efficient sorting of membrane components, and highlight the importance of stochastic effects for the steady-state organizati...