WorldWideScience

Sample records for pure epistatic effects

  1. Inference of epistatic effects in a key mitochondrial protein

    Science.gov (United States)

    Nelson, Erik D.; Grishin, Nick V.

    2018-06-01

    We use Potts model inference to predict pair epistatic effects in a key mitochondrial protein—cytochrome c oxidase subunit 2—for ray-finned fishes. We examine the effect of phylogenetic correlations on our predictions using a simple exact fitness model, and we find that, although epistatic effects are underpredicted, they maintain a roughly linear relationship to their true (model) values. After accounting for this correction, epistatic effects in the protein are still relatively weak, leading to fitness valleys of depth 2 N s ≃-5 in compensatory double mutants. Interestingly, positive epistasis is more pronounced than negative epistasis, and the strongest positive effects capture nearly all sites subject to positive selection in fishes, similar to virus proteins evolving under selection pressure in the context of drug therapy.

  2. PEPIS: A Pipeline for Estimating Epistatic Effects in Quantitative Trait Locus Mapping and Genome-Wide Association Studies.

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    Wenchao Zhang

    2016-05-01

    Full Text Available The term epistasis refers to interactions between multiple genetic loci. Genetic epistasis is important in regulating biological function and is considered to explain part of the 'missing heritability,' which involves marginal genetic effects that cannot be accounted for in genome-wide association studies. Thus, the study of epistasis is of great interest to geneticists. However, estimating epistatic effects for quantitative traits is challenging due to the large number of interaction effects that must be estimated, thus significantly increasing computing demands. Here, we present a new web server-based tool, the Pipeline for estimating EPIStatic genetic effects (PEPIS, for analyzing polygenic epistatic effects. The PEPIS software package is based on a new linear mixed model that has been used to predict the performance of hybrid rice. The PEPIS includes two main sub-pipelines: the first for kinship matrix calculation, and the second for polygenic component analyses and genome scanning for main and epistatic effects. To accommodate the demand for high-performance computation, the PEPIS utilizes C/C++ for mathematical matrix computing. In addition, the modules for kinship matrix calculations and main and epistatic-effect genome scanning employ parallel computing technology that effectively utilizes multiple computer nodes across our networked cluster, thus significantly improving the computational speed. For example, when analyzing the same immortalized F2 rice population genotypic data examined in a previous study, the PEPIS returned identical results at each analysis step with the original prototype R code, but the computational time was reduced from more than one month to about five minutes. These advances will help overcome the bottleneck frequently encountered in genome wide epistatic genetic effect analysis and enable accommodation of the high computational demand. The PEPIS is publically available at http://bioinfo.noble.org/PolyGenic_QTL/.

  3. PEPIS: A Pipeline for Estimating Epistatic Effects in Quantitative Trait Locus Mapping and Genome-Wide Association Studies.

    Science.gov (United States)

    Zhang, Wenchao; Dai, Xinbin; Wang, Qishan; Xu, Shizhong; Zhao, Patrick X

    2016-05-01

    The term epistasis refers to interactions between multiple genetic loci. Genetic epistasis is important in regulating biological function and is considered to explain part of the 'missing heritability,' which involves marginal genetic effects that cannot be accounted for in genome-wide association studies. Thus, the study of epistasis is of great interest to geneticists. However, estimating epistatic effects for quantitative traits is challenging due to the large number of interaction effects that must be estimated, thus significantly increasing computing demands. Here, we present a new web server-based tool, the Pipeline for estimating EPIStatic genetic effects (PEPIS), for analyzing polygenic epistatic effects. The PEPIS software package is based on a new linear mixed model that has been used to predict the performance of hybrid rice. The PEPIS includes two main sub-pipelines: the first for kinship matrix calculation, and the second for polygenic component analyses and genome scanning for main and epistatic effects. To accommodate the demand for high-performance computation, the PEPIS utilizes C/C++ for mathematical matrix computing. In addition, the modules for kinship matrix calculations and main and epistatic-effect genome scanning employ parallel computing technology that effectively utilizes multiple computer nodes across our networked cluster, thus significantly improving the computational speed. For example, when analyzing the same immortalized F2 rice population genotypic data examined in a previous study, the PEPIS returned identical results at each analysis step with the original prototype R code, but the computational time was reduced from more than one month to about five minutes. These advances will help overcome the bottleneck frequently encountered in genome wide epistatic genetic effect analysis and enable accommodation of the high computational demand. The PEPIS is publically available at http://bioinfo.noble.org/PolyGenic_QTL/.

  4. Prediction of genetic values of quantitative traits with epistatic effects in plant breeding populations.

    Science.gov (United States)

    Wang, D; Salah El-Basyoni, I; Stephen Baenziger, P; Crossa, J; Eskridge, K M; Dweikat, I

    2012-11-01

    Though epistasis has long been postulated to have a critical role in genetic regulation of important pathways as well as provide a major source of variation in the process of speciation, the importance of epistasis for genomic selection in the context of plant breeding is still being debated. In this paper, we report the results on the prediction of genetic values with epistatic effects for 280 accessions in the Nebraska Wheat Breeding Program using adaptive mixed least absolute shrinkage and selection operator (LASSO). The development of adaptive mixed LASSO, originally designed for association mapping, for the context of genomic selection is reported. The results show that adaptive mixed LASSO can be successfully applied to the prediction of genetic values while incorporating both marker main effects and epistatic effects. Especially, the prediction accuracy is substantially improved by the inclusion of two-locus epistatic effects (more than onefold in some cases as measured by cross-validation correlation coefficient), which is observed for multiple traits and planting locations. This points to significant potential in using non-additive genetic effects for genomic selection in crop breeding practices.

  5. Epistatic interactions on chromosome 14 influencing stillbirth in Fleckvieh cattle

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    Gábor Mészáros

    2016-09-01

    Full Text Available Single nucleotide polymorphism (SNP data of 7384 Fleckvieh bulls was analyzed to identify epistatic interactions influencing stillbirth. Deregressed breeding values were used as phenotypes. The epistatic effects were identified as significant interaction terms from pairwise linear regressions performed for each SNP after accounting for multiple testing. Majority of the detected epistatic effects were located in the 9-31Mb region of chromosome 14, corresponding to the most significant region from the genome wide association. Additional epistatic SNPs at 50.5Mb and 80.5 Mb at the same chromosome were detected. The region around 25 Mb contained genes connected to height and body size such as PLAG1, CHCHD7, LYN, RDHE2 (SDR16C5 and PENK. The other interesting region at 50.5Mb contained the TRPS1 gene influencing bone malformations. Both regions have been identified as candidates influencing stillbirth.

  6. An information-gain approach to detecting three-way epistatic interactions in genetic association studies

    DEFF Research Database (Denmark)

    Hu, Ting; Chen, Yuanzhu; Kiralis, Jeff W

    2013-01-01

    Background Epistasis has been historically used to describe the phenomenon that the effect of a given gene on a phenotype can be dependent on one or more other genes, and is an essential element for understanding the association between genetic and phenotypic variations. Quantifying epistasis......-way epistasis. Methods Such a measure is based on information gain, and is able to separate all lower order effects from pure three-way epistasis. Results Our method was verified on synthetic data and applied to real data from a candidate-gene study of tuberculosis in a West African population....... In the tuberculosis data, we found a statistically significant pure three-way epistatic interaction effect that was stronger than any lower-order associations. Conclusion Our study provides a methodological basis for detecting and characterizing high-order gene-gene interactions in genetic association studies....

  7. Epistatic association mapping in homozygous crop cultivars.

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    Hai-Yan Lü

    Full Text Available The genetic dissection of complex traits plays a crucial role in crop breeding. However, genetic analysis and crop breeding have heretofore been performed separately. In this study, we designed a new approach that integrates epistatic association analysis in crop cultivars with breeding by design. First, we proposed an epistatic association mapping (EAM approach in homozygous crop cultivars. The phenotypic values of complex traits, along with molecular marker information, were used to perform EAM. In our EAM, all the main-effect quantitative trait loci (QTLs, environmental effects, QTL-by-environment interactions and QTL-by-QTL interactions were included in a full model and estimated by empirical Bayes approach. A series of Monte Carlo simulations was performed to confirm the reliability of the new method. Next, the information from all detected QTLs was used to mine novel alleles for each locus and to design elite cross combination. Finally, the new approach was adopted to dissect the genetic basis of seed length in 215 soybean cultivars obtained, by stratified random sampling, from 6 geographic ecotypes in China. As a result, 19 main-effect QTLs and 3 epistatic QTLs were identified, more than 10 novel alleles were mined and 3 elite parental combinations, such as Daqingdou and Zhengzhou790034, were predicted.

  8. Genomic value prediction for quantitative traits under the epistatic model

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    Xu Shizhong

    2011-01-01

    Full Text Available Abstract Background Most quantitative traits are controlled by multiple quantitative trait loci (QTL. The contribution of each locus may be negligible but the collective contribution of all loci is usually significant. Genome selection that uses markers of the entire genome to predict the genomic values of individual plants or animals can be more efficient than selection on phenotypic values and pedigree information alone for genetic improvement. When a quantitative trait is contributed by epistatic effects, using all markers (main effects and marker pairs (epistatic effects to predict the genomic values of plants can achieve the maximum efficiency for genetic improvement. Results In this study, we created 126 recombinant inbred lines of soybean and genotyped 80 makers across the genome. We applied the genome selection technique to predict the genomic value of somatic embryo number (a quantitative trait for each line. Cross validation analysis showed that the squared correlation coefficient between the observed and predicted embryo numbers was 0.33 when only main (additive effects were used for prediction. When the interaction (epistatic effects were also included in the model, the squared correlation coefficient reached 0.78. Conclusions This study provided an excellent example for the application of genome selection to plant breeding.

  9. Epistatic effects contribute to variation in BMD in Fischer 344 x Lewis F2 rats.

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    Koller, Daniel L; Liu, Lixiang; Alam, Imranul; Sun, Qiwei; Econs, Michael J; Foroud, Tatiana; Turner, Charles H

    2008-01-01

    To further delineate the factors underlying the complex genetic architecture of BMD in the rat model, a genome screen for epistatic interactions was conducted. Several significant interactions were identified, involving both previously identified and novel QTLs. The variation in several of the risk factors for osteoporotic fracture, including BMD, has been shown to be caused largely by genetic differences. However, the genetic architecture of BMD is complex in both humans and in model organisms. We have previously reported quantitative trait locus (QTL) results for BMD from a genome screen of 595 female F(2) progeny of Fischer 344 and Lewis rats. These progeny also provide an excellent opportunity to search for epistatic effects, or interaction between genetic loci, that contribute to fracture risk. Microsatellite marker data from a 20-cM genome screen was analyzed along with weight-adjusted BMD (DXA and pQCT) phenotypic data using the R/qtl software package. Genotype and phenotype data were permuted to determine a genome-wide significance threshold for the epistasis or interaction LOD score corresponding to an alpha level of 0.01. Novel loci on chromosomes 12 and 15 showed a strong epistatic effect on total BMD at the femoral midshaft by pQCT (LOD = 5.4). A previously reported QTL on chromosome 7 was found to interact with a novel locus on chromosome 20 to affect whole lumbar BMD by pQCT (LOD = 6.2). These results provide new information regarding the mode of action of previously identified rat QTLs, as well as identifying novel loci that act in combination with known QTLs or with other novel loci to contribute to the risk factors for osteoporotic fracture.

  10. Mechanistic basis of an epistatic interaction reducing age at onset in hereditary spastic paraplegia.

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    Newton, Timothy; Allison, Rachel; Edgar, James R; Lumb, Jennifer H; Rodger, Catherine E; Manna, Paul T; Rizo, Tania; Kohl, Zacharias; Nygren, Anders O H; Arning, Larissa; Schüle, Rebecca; Depienne, Christel; Goldberg, Lisa; Frahm, Christiane; Stevanin, Giovanni; Durr, Alexandra; Schöls, Ludger; Winner, Beate; Beetz, Christian; Reid, Evan

    2018-05-01

    Many genetic neurological disorders exhibit variable expression within affected families, often exemplified by variations in disease age at onset. Epistatic effects (i.e. effects of modifier genes on the disease gene) may underlie this variation, but the mechanistic basis for such epistatic interactions is rarely understood. Here we report a novel epistatic interaction between SPAST and the contiguous gene DPY30, which modifies age at onset in hereditary spastic paraplegia, a genetic axonopathy. We found that patients with hereditary spastic paraplegia caused by genomic deletions of SPAST that extended into DPY30 had a significantly younger age at onset. We show that, like spastin, the protein encoded by SPAST, the DPY30 protein controls endosomal tubule fission, traffic of mannose 6-phosphate receptors from endosomes to the Golgi, and lysosomal ultrastructural morphology. We propose that additive effects on this pathway explain the reduced age at onset of hereditary spastic paraplegia in patients who are haploinsufficient for both genes.

  11. Epistatic Effects Contribute to Variation in BMD in Fischer 344 × Lewis F2 Rats

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    Koller, Daniel L; Liu, Lixiang; Alam, Imranul; Sun, Qiwei; Econs, Michael J; Foroud, Tatiana; Turner, Charles H

    2008-01-01

    To further delineate the factors underlying the complex genetic architecture of BMD in the rat model, a genome screen for epistatic interactions was conducted. Several significant interactions were identified, involving both previously identified and novel QTLs. Introduction The variation in several of the risk factors for osteoporotic fracture, including BMD, has been shown to be caused largely by genetic differences. However, the genetic architecture of BMD is complex in both humans and in model organisms. We have previously reported quantitative trait locus (QTL) results for BMD from a genome screen of 595 female F2 progeny of Fischer 344 and Lewis rats. These progeny also provide an excellent opportunity to search for epistatic effects, or interaction between genetic loci, that contribute to fracture risk. Materials and Methods Microsatellite marker data from a 20-cM genome screen was analyzed along with weight-adjusted BMD (DXA and pQCT) phenotypic data using the R/qtl software package. Genotype and phenotype data were permuted to determine a genome-wide significance threshold for the epistasis or interaction LOD score corresponding to an α level of 0.01. Results and Conclusions Novel loci on chromosomes 12 and 15 showed a strong epistatic effect on total BMD at the femoral midshaft by pQCT (LOD = 5.4). A previously reported QTL on chromosome 7 was found to interact with a novel locus on chromosome 20 to affect whole lumbar BMD by pQCT (LOD = 6.2). These results provide new information regarding the mode of action of previously identified rat QTLs, as well as identifying novel loci that act in combination with known QTLs or with other novel loci to contribute to the risk factors for osteoporotic fracture. PMID:17907919

  12. Improved functional overview of protein complexes using inferred epistatic relationships

    LENUS (Irish Health Repository)

    Ryan, Colm

    2011-05-23

    Abstract Background Epistatic Miniarray Profiling(E-MAP) quantifies the net effect on growth rate of disrupting pairs of genes, often producing phenotypes that may be more (negative epistasis) or less (positive epistasis) severe than the phenotype predicted based on single gene disruptions. Epistatic interactions are important for understanding cell biology because they define relationships between individual genes, and between sets of genes involved in biochemical pathways and protein complexes. Each E-MAP screen quantifies the interactions between a logically selected subset of genes (e.g. genes whose products share a common function). Interactions that occur between genes involved in different cellular processes are not as frequently measured, yet these interactions are important for providing an overview of cellular organization. Results We introduce a method for combining overlapping E-MAP screens and inferring new interactions between them. We use this method to infer with high confidence 2,240 new strongly epistatic interactions and 34,469 weakly epistatic or neutral interactions. We show that accuracy of the predicted interactions approaches that of replicate experiments and that, like measured interactions, they are enriched for features such as shared biochemical pathways and knockout phenotypes. We constructed an expanded epistasis map for yeast cell protein complexes and show that our new interactions increase the evidence for previously proposed inter-complex connections, and predict many new links. We validated a number of these in the laboratory, including new interactions linking the SWR-C chromatin modifying complex and the nuclear transport apparatus. Conclusion Overall, our data support a modular model of yeast cell protein network organization and show how prediction methods can considerably extend the information that can be extracted from overlapping E-MAP screens.

  13. bNEAT: a Bayesian network method for detecting epistatic interactions in genome-wide association studies

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    Chen Xue-wen

    2011-07-01

    Full Text Available Abstract Background Detecting epistatic interactions plays a significant role in improving pathogenesis, prevention, diagnosis and treatment of complex human diseases. A recent study in automatic detection of epistatic interactions shows that Markov Blanket-based methods are capable of finding genetic variants strongly associated with common diseases and reducing false positives when the number of instances is large. Unfortunately, a typical dataset from genome-wide association studies consists of very limited number of examples, where current methods including Markov Blanket-based method may perform poorly. Results To address small sample problems, we propose a Bayesian network-based approach (bNEAT to detect epistatic interactions. The proposed method also employs a Branch-and-Bound technique for learning. We apply the proposed method to simulated datasets based on four disease models and a real dataset. Experimental results show that our method outperforms Markov Blanket-based methods and other commonly-used methods, especially when the number of samples is small. Conclusions Our results show bNEAT can obtain a strong power regardless of the number of samples and is especially suitable for detecting epistatic interactions with slight or no marginal effects. The merits of the proposed approach lie in two aspects: a suitable score for Bayesian network structure learning that can reflect higher-order epistatic interactions and a heuristic Bayesian network structure learning method.

  14. uvsI mutants defective in UV mutagenesis define a fourth epistatic group of uvs genes in Aspergillus.

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    Chae, S K; Kafer, E

    1993-01-01

    Three UV-sensitive mutations of A. nidulans, uvsI, uvsJ and uvsA, were tested for epistatic relationships with members of the previously established groups, here called the "UvsF", "UvsC", and "UvsB" groups. uvsI mutants are defective for spontaneous and induced reversion of certain point mutations and differ also for other properties from previously analyzed uvs types. They are very sensitive to the killing effects of UV-light and 4-NQO (4-nitro-quinoline-N-oxide) but not to MMS (methylmethane sulfonate). When double- and single-mutant uvs strains were compared for sensitivity to these three agents, synergistic or additive effects were found for uvsI with all members of the three groups. The uvsI gene may therefore represent a fourth epistatic group, possibly involved in mutagenic repair. On the other hand, uvsJ was clearly epistatic with members of the UvsF group and fitted well into this group also by phenotype. The uvsA gene was tentatively assigned to the UvsC group. uvsA showed epistatic interactions with uvsC in all tests, and like UvsC-group mutants is UV-sensitive mainly in dividing cells. However, the uvsA mutation does not cause the defects in recombination and UV mutagenesis typical for this group.

  15. Understanding Epistatic Interactions between Genes Targeted by Non-coding Regulatory Elements in Complex Diseases

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    Min Kyung Sung

    2014-12-01

    Full Text Available Genome-wide association studies have proven the highly polygenic architecture of complex diseases or traits; therefore, single-locus-based methods are usually unable to detect all involved loci, especially when individual loci exert small effects. Moreover, the majority of associated single-nucleotide polymorphisms resides in non-coding regions, making it difficult to understand their phenotypic contribution. In this work, we studied epistatic interactions associated with three common diseases using Korea Association Resource (KARE data: type 2 diabetes mellitus (DM, hypertension (HT, and coronary artery disease (CAD. We showed that epistatic single-nucleotide polymorphisms (SNPs were enriched in enhancers, as well as in DNase I footprints (the Encyclopedia of DNA Elements [ENCODE] Project Consortium 2012, which suggested that the disruption of the regulatory regions where transcription factors bind may be involved in the disease mechanism. Accordingly, to identify the genes affected by the SNPs, we employed whole-genome multiple-cell-type enhancer data which discovered using DNase I profiles and Cap Analysis Gene Expression (CAGE. Assigned genes were significantly enriched in known disease associated gene sets, which were explored based on the literature, suggesting that this approach is useful for detecting relevant affected genes. In our knowledge-based epistatic network, the three diseases share many associated genes and are also closely related with each other through many epistatic interactions. These findings elucidate the genetic basis of the close relationship between DM, HT, and CAD.

  16. Missing value imputation for epistatic MAPs

    LENUS (Irish Health Repository)

    Ryan, Colm

    2010-04-20

    Abstract Background Epistatic miniarray profiling (E-MAPs) is a high-throughput approach capable of quantifying aggravating or alleviating genetic interactions between gene pairs. The datasets resulting from E-MAP experiments typically take the form of a symmetric pairwise matrix of interaction scores. These datasets have a significant number of missing values - up to 35% - that can reduce the effectiveness of some data analysis techniques and prevent the use of others. An effective method for imputing interactions would therefore increase the types of possible analysis, as well as increase the potential to identify novel functional interactions between gene pairs. Several methods have been developed to handle missing values in microarray data, but it is unclear how applicable these methods are to E-MAP data because of their pairwise nature and the significantly larger number of missing values. Here we evaluate four alternative imputation strategies, three local (Nearest neighbor-based) and one global (PCA-based), that have been modified to work with symmetric pairwise data. Results We identify different categories for the missing data based on their underlying cause, and show that values from the largest category can be imputed effectively. We compare local and global imputation approaches across a variety of distinct E-MAP datasets, showing that both are competitive and preferable to filling in with zeros. In addition we show that these methods are effective in an E-MAP from a different species, suggesting that pairwise imputation techniques will be increasingly useful as analogous epistasis mapping techniques are developed in different species. We show that strongly alleviating interactions are significantly more difficult to predict than strongly aggravating interactions. Finally we show that imputed interactions, generated using nearest neighbor methods, are enriched for annotations in the same manner as measured interactions. Therefore our method potentially

  17. Phenotypic and epistatic grouping of hypo- and hyper-rec mus mutants in Aspergillus.

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    Kafer, E; Chae, S K

    1994-03-01

    The mutants musK to musS of Aspergillus nidulans are sensitive to methyl-methanesulfonate (MMS) and several of them are meiotic-defective and alter mitotic recombination frequencies. All were found to be cross-sensitive to 4-nitro-quinoline-N-oxide (4-NQO) but unexpectedly none of them was hypersensitive to gamma-rays and few to UV light. Double mus; uvs mutants were constructed to test for interactions with uvs mutations of the four epistatic groups of Aspergillus, "UvsF", "UvsC", "UvsI", and "UvsB". All meiotic-defective mus mutations caused some lethal interactions, usually with uvsF. None of them showed epistasis with UvsF or UvsB group mutants and one, musO, may represent a new group. Three mus mutations that affect recombination were assigned to the UvsC group, namely musN and K, and also musL which is recombination-defective and closely resembles uvsC. While uvsC mutants are mutators and lack UV-mutagenesis, most mus mutants had no effects on mutation. Only musR, which appeared epistatic with uvsI, showed reduced UV-reversion frequencies similar to uvsI. The recombination-proficient mus mutants appeared to be epistatic with more than one group, but in several cases sensitivities were slight and overlaps insufficient to obtain corroborating results with MMS and 4-NQO.

  18. Epistatic adaptive evolution of human color vision.

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    Shozo Yokoyama

    2014-12-01

    Full Text Available Establishing genotype-phenotype relationship is the key to understand the molecular mechanism of phenotypic adaptation. This initial step may be untangled by analyzing appropriate ancestral molecules, but it is a daunting task to recapitulate the evolution of non-additive (epistatic interactions of amino acids and function of a protein separately. To adapt to the ultraviolet (UV-free retinal environment, the short wavelength-sensitive (SWS1 visual pigment in human (human S1 switched from detecting UV to absorbing blue light during the last 90 million years. Mutagenesis experiments of the UV-sensitive pigment in the Boreoeutherian ancestor show that the blue-sensitivity was achieved by seven mutations. The experimental and quantum chemical analyses show that 4,008 of all 5,040 possible evolutionary trajectories are terminated prematurely by containing a dehydrated nonfunctional pigment. Phylogenetic analysis further suggests that human ancestors achieved the blue-sensitivity gradually and almost exclusively by epistasis. When the final stage of spectral tuning of human S1 was underway 45-30 million years ago, the middle and long wavelength-sensitive (MWS/LWS pigments appeared and so-called trichromatic color vision was established by interprotein epistasis. The adaptive evolution of human S1 differs dramatically from orthologous pigments with a major mutational effect used in achieving blue-sensitivity in a fish and several mammalian species and in regaining UV vision in birds. These observations imply that the mechanisms of epistatic interactions must be understood by studying various orthologues in different species that have adapted to various ecological and physiological environments.

  19. Modularization and epistatic hierarchy determine homeostatic actions of multiple blood pressure quantitative trait loci.

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    Chauvet, Cristina; Crespo, Kimberley; Ménard, Annie; Roy, Julie; Deng, Alan Y

    2013-11-15

    Hypertension, the most frequently diagnosed clinical condition world-wide, predisposes individuals to morbidity and mortality, yet its underlying pathological etiologies are poorly understood. So far, a large number of quantitative trait loci (QTLs) have been identified in both humans and animal models, but how they function together in determining overall blood pressure (BP) in physiological settings is unknown. Here, we systematically and comprehensively performed pair-wise comparisons of individual QTLs to create a global picture of their functionality in an inbred rat model. Rather than each of numerous QTLs contributing to infinitesimal BP increments, a modularized pattern arises: two epistatic 'blocks' constitute basic functional 'units' for nearly all QTLs, designated as epistatic module 1 (EM1) and EM2. This modularization dictates the magnitude and scope of BP effects. Any EM1 member can contribute to BP additively to that of EM2, but not to those of the same module. Members of each EM display epistatic hierarchy, which seems to reflect a related functional pathway. Rat homologues of 11 human BP QTLs belong to either EM1 or EM2. Unique insights emerge into the novel genetic mechanism and hierarchy determining BP in the Dahl salt-sensitive SS/Jr (DSS) rat model that implicate a portion of human QTLs. Elucidating the pathways underlying EM1 and EM2 may reveal the genetic regulation of BP.

  20. An empirical comparison of several recent epistatic interaction detection methods.

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    Wang, Yue; Liu, Guimei; Feng, Mengling; Wong, Limsoon

    2011-11-01

    Many new methods have recently been proposed for detecting epistatic interactions in GWAS data. There is, however, no in-depth independent comparison of these methods yet. Five recent methods-TEAM, BOOST, SNPHarvester, SNPRuler and Screen and Clean (SC)-are evaluated here in terms of power, type-1 error rate, scalability and completeness. In terms of power, TEAM performs best on data with main effect and BOOST performs best on data without main effect. In terms of type-1 error rate, TEAM and BOOST have higher type-1 error rates than SNPRuler and SNPHarvester. SC does not control type-1 error rate well. In terms of scalability, we tested the five methods using a dataset with 100 000 SNPs on a 64 bit Ubuntu system, with Intel (R) Xeon(R) CPU 2.66 GHz, 16 GB memory. TEAM takes ~36 days to finish and SNPRuler reports heap allocation problems. BOOST scales up to 100 000 SNPs and the cost is much lower than that of TEAM. SC and SNPHarvester are the most scalable. In terms of completeness, we study how frequently the pruning techniques employed by these methods incorrectly prune away the most significant epistatic interactions. We find that, on average, 20% of datasets without main effect and 60% of datasets with main effect are pruned incorrectly by BOOST, SNPRuler and SNPHarvester. The software for the five methods tested are available from the URLs below. TEAM: http://csbio.unc.edu/epistasis/download.php BOOST: http://ihome.ust.hk/~eeyang/papers.html. SNPHarvester: http://bioinformatics.ust.hk/SNPHarvester.html. SNPRuler: http://bioinformatics.ust.hk/SNPRuler.zip. Screen and Clean: http://wpicr.wpic.pitt.edu/WPICCompGen/. wangyue@nus.edu.sg.

  1. Epistatic determinism of durum wheat resistance to the wheat spindle streak mosaic virus.

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    Holtz, Yan; Bonnefoy, Michel; Viader, Véronique; Ardisson, Morgane; Rode, Nicolas O; Poux, Gérard; Roumet, Pierre; Marie-Jeanne, Véronique; Ranwez, Vincent; Santoni, Sylvain; Gouache, David; David, Jacques L

    2017-07-01

    The resistance of durum wheat to the Wheat spindle streak mosaic virus (WSSMV) is controlled by two main QTLs on chromosomes 7A and 7B, with a huge epistatic effect. Wheat spindle streak mosaic virus (WSSMV) is a major disease of durum wheat in Europe and North America. Breeding WSSMV-resistant cultivars is currently the only way to control the virus since no treatment is available. This paper reports studies of the inheritance of WSSMV resistance using two related durum wheat populations obtained by crossing two elite cultivars with a WSSMV-resistant emmer cultivar. In 2012 and 2015, 354 recombinant inbred lines (RIL) were phenotyped using visual notations, ELISA and qPCR and genotyped using locus targeted capture and sequencing. This allowed us to build a consensus genetic map of 8568 markers and identify three chromosomal regions involved in WSSMV resistance. Two major regions (located on chromosomes 7A and 7B) jointly explain, on the basis of epistatic interactions, up to 43% of the phenotypic variation. Flanking sequences of our genetic markers are provided to facilitate future marker-assisted selection of WSSMV-resistant cultivars.

  2. The role of epistatic interactions underpinning resistance to parasitic Varroa mites in haploid honey bee (Apis mellifera) drones.

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    Conlon, Benjamin H; Frey, Eva; Rosenkranz, Peter; Locke, Barbara; Moritz, Robin F A; Routtu, Jarkko

    2018-06-01

    The Red Queen hypothesis predicts that host-parasite coevolutionary dynamics can select for host resistance through increased genetic diversity, recombination and evolutionary rates. However, in haplodiploid organisms such as the honeybee (Apis mellifera), models suggest the selective pressure is weaker than in diploids. Haplodiploid sex determination, found in A. mellifera, can allow deleterious recessive alleles to persist in the population through the diploid sex with negative effects predominantly expressed in the haploid sex. To overcome these negative effects in haploid genomes, epistatic interactions have been hypothesized to play an important role. Here, we use the interaction between A. mellifera and the parasitic mite Varroa destructor to test epistasis in the expression of resistance, through the inhibition of parasite reproduction, in haploid drones. We find novel loci on three chromosomes which explain over 45% of the resistance phenotype. Two of these loci interact only additively, suggesting their expression is independent of each other, but both loci interact epistatically with the third locus. With drone offspring inheriting only one copy of the queen's chromosomes, the drones will only possess one of two queen alleles throughout the years-long lifetime of the honeybee colony. Varroa, in comparison, completes its highly inbred reproductive cycle in a matter of weeks, allowing it to rapidly evolve resistance. Faced with the rapidly evolving Varroa, a diversity of pathways and epistatic interactions for the inhibition of Varroa reproduction could therefore provide a selective advantage to the high levels of recombination seen in A. mellifera. This allows for the remixing of phenotypes despite a fixed queen genotype. © 2018 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2018 European Society For Evolutionary Biology.

  3. Identification of quantitative trait loci underlying seed protein content of soybean including main, epistatic, and QTL × environment effects in different regions of Northeast China.

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    Teng, Weili; Li, Wen; Zhang, Qi; Wu, Depeng; Zhao, Xue; Li, Haiyan; Han, Yingpeng; Li, Wenbin

    2017-08-01

    The objective here was to identify QTL underlying soybean protein content (PC), and to evaluate the additive and epistatic effects of the QTLs. A mapping population, consisting of 129 recombinant inbred lines (RILs), was created by crossing 'Dongnong 46' and 'L-100'. Phenotypic data of the parents and RILs were collected for 4 years in three locations of Heilongjiang Province of China. A total of 213 SSR markers were used to construct a genetic linkage map. Eight QTLs, located on seven chromosomes (Chr), were identified to be associated with PC among the 10 tested environments. Of the seven QTLs, five QTLs, qPR-2 (Satt710, on Chr9), qPR-3 (Sat_122, on Chr12), qPR-5 (Satt543, on Chr17), qPR-7 (Satt163, on Chr18), and qPR-8 (Satt614, on Chr20), were detected in six, seven, seven, six, and seven environments, respectively, implying relatively stable QTLs. qPR-3 could explain 3.33%-11.26% of the phenotypic variation across eight tested environments. qPR-5 and qPR-8 explained 3.64%-10.1% and 11.86%-18.40% of the phenotypic variation, respectively, across seven tested environments. Eight QTLs associated with PC exhibited additive and (or) additive × environment interaction effects. The results showed that environment-independent QTLs often had higher additive effects. Moreover, five epistatic pairwise QTLs were identified in the 10 environments.

  4. Testing effects in mixed- versus pure-list designs.

    Science.gov (United States)

    Rowland, Christopher A; Littrell-Baez, Megan K; Sensenig, Amanda E; DeLosh, Edward L

    2014-08-01

    In the present study, we investigated the role of list composition in the testing effect. Across three experiments, participants learned items through study and initial testing or study and restudy. List composition was manipulated, such that tested and restudied items appeared either intermixed in the same lists (mixed lists) or in separate lists (pure lists). In Experiment 1, half of the participants received mixed lists and half received pure lists. In Experiment 2, all participants were given both mixed and pure lists. Experiment 3 followed Erlebacher's (Psychological Bulletin, 84, 212-219, 1977) method, such that mixed lists, pure tested lists, and pure restudied lists were given to independent groups. Across all three experiments, the final recall results revealed significant testing effects for both mixed and pure lists, with no reliable difference in the magnitude of the testing advantage across list designs. This finding suggests that the testing effect is not subject to a key boundary condition-list design-that impacts other memory phenomena, including the generation effect.

  5. Hybrid male sterility in rice is due to epistatic interactions with a pollen killer locus.

    Science.gov (United States)

    Kubo, Takahiko; Yoshimura, Atsushi; Kurata, Nori

    2011-11-01

    In intraspecific crosses between cultivated rice (Oryza sativa) subspecies indica and japonica, the hybrid male sterility gene S24 causes the selective abortion of male gametes carrying the japonica allele (S24-j) via an allelic interaction in the heterozygous hybrids. In this study, we first examined whether male sterility is due solely to the single locus S24. An analysis of near-isogenic lines (NIL-F(1)) showed different phenotypes for S24 in different genetic backgrounds. The S24 heterozygote with the japonica genetic background showed male semisterility, but no sterility was found in heterozygotes with the indica background. This result indicates that S24 is regulated epistatically. A QTL analysis of a BC(2)F(1) population revealed a novel sterility locus that interacts with S24 and is found on rice chromosome 2. The locus was named Epistatic Factor for S24 (EFS). Further genetic analyses revealed that S24 causes male sterility when in combination with the homozygous japonica EFS allele (efs-j). The results suggest that efs-j is a recessive sporophytic allele, while the indica allele (EFS-i) can dominantly counteract the pollen sterility caused by S24 heterozygosity. In summary, our results demonstrate that an additional epistatic locus is an essential element in the hybrid sterility caused by allelic interaction at a single locus in rice. This finding provides a significant contribution to our understanding of the complex molecular mechanisms underlying hybrid sterility and microsporogenesis.

  6. Strong Selection Significantly Increases Epistatic Interactions in the Long-Term Evolution of a Protein.

    Directory of Open Access Journals (Sweden)

    Aditi Gupta

    2016-03-01

    Full Text Available Epistatic interactions between residues determine a protein's adaptability and shape its evolutionary trajectory. When a protein experiences a changed environment, it is under strong selection to find a peak in the new fitness landscape. It has been shown that strong selection increases epistatic interactions as well as the ruggedness of the fitness landscape, but little is known about how the epistatic interactions change under selection in the long-term evolution of a protein. Here we analyze the evolution of epistasis in the protease of the human immunodeficiency virus type 1 (HIV-1 using protease sequences collected for almost a decade from both treated and untreated patients, to understand how epistasis changes and how those changes impact the long-term evolvability of a protein. We use an information-theoretic proxy for epistasis that quantifies the co-variation between sites, and show that positive information is a necessary (but not sufficient condition that detects epistasis in most cases. We analyze the "fossils" of the evolutionary trajectories of the protein contained in the sequence data, and show that epistasis continues to enrich under strong selection, but not for proteins whose environment is unchanged. The increase in epistasis compensates for the information loss due to sequence variability brought about by treatment, and facilitates adaptation in the increasingly rugged fitness landscape of treatment. While epistasis is thought to enhance evolvability via valley-crossing early-on in adaptation, it can hinder adaptation later when the landscape has turned rugged. However, we find no evidence that the HIV-1 protease has reached its potential for evolution after 9 years of adapting to a drug environment that itself is constantly changing. We suggest that the mechanism of encoding new information into pairwise interactions is central to protein evolution not just in HIV-1 protease, but for any protein adapting to a changing

  7. Lack of evidence for intermolecular epistatic interactions between adiponectin and resistin gene polymorphisms in Malaysian male subjects

    Directory of Open Access Journals (Sweden)

    Cia-Hin Lau

    2012-01-01

    Full Text Available Epistasis (gene-gene interaction is a ubiquitous component of the genetic architecture of complex traits such as susceptibility to common human diseases. Given the strong negative correlation between circulating adiponectin and resistin levels, the potential intermolecular epistatic interactions between ADIPOQ (SNP+45T > G, SNP+276G > T, SNP+639T > C and SNP+1212A > G and RETN (SNP-420C > G and SNP+299G > A gene polymorphisms in the genetic risk underlying type 2 diabetes (T2DM and metabolic syndrome (MS were assessed. The potential mutual influence of the ADIPOQ and RETN genes on their adipokine levels was also examined. The rare homozygous genotype (risk alleles of SNP-420C > G at the RETN locus tended to be co-inherited together with the common homozygous genotypes (protective alleles of SNP+639T > C and SNP+1212A > G at the ADIPOQ locus. Despite the close structural relationship between the ADIPOQ and RETN genes, there was no evidence of an intermolecular epistatic interaction between these genes. There was also no reciprocal effect of the ADIPOQ and RETN genes on their adipokine levels, i.e., ADIPOQ did not affect resistin levels nor did RETN affect adiponectin levels. The possible influence of the ADIPOQ gene on RETN expression warrants further investigation.

  8. A bi-dimensional genome scan for prolificacy traits in pigs shows the existence of multiple epistatic QTL

    Directory of Open Access Journals (Sweden)

    Bidanel Jean P

    2009-12-01

    Full Text Available Abstract Background Prolificacy is the most important trait influencing the reproductive efficiency of pig production systems. The low heritability and sex-limited expression of prolificacy have hindered to some extent the improvement of this trait through artificial selection. Moreover, the relative contributions of additive, dominant and epistatic QTL to the genetic variance of pig prolificacy remain to be defined. In this work, we have undertaken this issue by performing one-dimensional and bi-dimensional genome scans for number of piglets born alive (NBA and total number of piglets born (TNB in a three generation Iberian by Meishan F2 intercross. Results The one-dimensional genome scan for NBA and TNB revealed the existence of two genome-wide highly significant QTL located on SSC13 (P SSC17 (P P P P P Conclusions The complex inheritance of prolificacy traits in pigs has been evidenced by identifying multiple additive (SSC13 and SSC17, dominant and epistatic QTL in an Iberian × Meishan F2 intercross. Our results demonstrate that a significant fraction of the phenotypic variance of swine prolificacy traits can be attributed to first-order gene-by-gene interactions emphasizing that the phenotypic effects of alleles might be strongly modulated by the genetic background where they segregate.

  9. Multifactor dimensionality reduction reveals a three-locus epistatic interaction associated with susceptibility to pulmonary tuberculosis

    DEFF Research Database (Denmark)

    Collins, Ryan L; Hu, Ting; Wejse, Christian

    2013-01-01

    for this problem. The goal of the present study was to apply MDR to mining high-order epistatic interactions in a population-based genetic study of tuberculosis (TB). Results The study used a previously published data set consisting of 19 candidate single-nucleotide polymorphisms (SNPs) in 321 pulmonary TB cases...

  10. An epistatic effect of KRT25 on SP6 is involved in curly coat in horses.

    Science.gov (United States)

    Thomer, Annika; Gottschalk, Maren; Christmann, Anna; Naccache, Fanny; Jung, Klaus; Hewicker-Trautwein, Marion; Distl, Ottmar; Metzger, Julia

    2018-04-23

    Curly coat represents an extraordinary type of coat in horses, particularly seen in American Bashkir Curly Horses and Missouri Foxtrotters. In some horses with curly coat, a hypotrichosis of variable extent was observed, making the phenotype appear more complex. In our study, we aimed at investigating the genetic background of curly coat with and without hypotrichosis using high density bead chip genotype and next generation sequencing data. Genome-wide association analysis detected significant signals (p = 1.412 × 10 -05 -1.102 × 10 -08 ) on horse chromosome 11 at 22-35 Mb. In this significantly associated region, six missense variants were filtered out from whole-genome sequencing data of three curly coated horses of which two variants within KRT25 and SP6 could explain all hair phenotypes. Horses heterozygous or homozygous only for KRT25 variant showed curly coat and hypotrichosis, whereas horses with SP6 variant only, exhibited curly coat without hypotrichosis. Horses with mutant alleles in both variants developed curly hair and hypotrichosis. Thus, mutant KRT25 allele is masking SP6 allele effect, indicative for epistasis of KRT25 variant over SP6 variant. In summary, genetic variants in two different genes, KRT25 and SP6, are responsible for curly hair. All horses with KRT25 variant are additionally hypotrichotic due to the KRT25 epistatic effect on SP6.

  11. Stripe rust and leaf rust resistance QTL mapping, epistatic interactions, and co-localization with stem rust resistance loci in spring wheat evaluated over three continents.

    Science.gov (United States)

    Singh, A; Knox, R E; DePauw, R M; Singh, A K; Cuthbert, R D; Campbell, H L; Shorter, S; Bhavani, S

    2014-11-01

    In wheat, advantageous gene-rich or pleiotropic regions for stripe, leaf, and stem rust and epistatic interactions between rust resistance loci should be accounted for in plant breeding strategies. Leaf rust (Puccinia triticina Eriks.) and stripe rust (Puccinia striiformis f. tritici Eriks) contribute to major production losses in many regions worldwide. The objectives of this research were to identify and study epistatic interactions of quantitative trait loci (QTL) for stripe and leaf rust resistance in a doubled haploid (DH) population derived from the cross of Canadian wheat cultivars, AC Cadillac and Carberry. The relationship of leaf and stripe rust resistance QTL that co-located with stem rust resistance QTL previously mapped in this population was also investigated. The Carberry/AC Cadillac population was genotyped with DArT(®) and simple sequence repeat markers. The parents and population were phenotyped for stripe rust severity and infection response in field rust nurseries in Kenya (Njoro), Canada (Swift Current), and New Zealand (Lincoln); and for leaf rust severity and infection response in field nurseries in Canada (Swift Current) and New Zealand (Lincoln). AC Cadillac was a source of stripe rust resistance QTL on chromosomes 2A, 2B, 3A, 3B, 5B, and 7B; and Carberry was a source of resistance on chromosomes 2B, 4B, and 7A. AC Cadillac contributed QTL for resistance to leaf rust on chromosome 2A and Carberry contributed QTL on chromosomes 2B and 4B. Stripe rust resistance QTL co-localized with previously reported stem rust resistance QTL on 2B, 3B, and 7B, while leaf rust resistance QTL co-localized with 4B stem rust resistance QTL. Several epistatic interactions were identified both for stripe and leaf rust resistance QTL. We have identified useful combinations of genetic loci with main and epistatic effects. Multiple disease resistance regions identified on chromosomes 2A, 2B, 3B, 4B, 5B, and 7B are prime candidates for further investigation and

  12. QTL mapping and epistatic interaction analysis in asparagus bean for several characterized and novel horticulturally important traits

    Science.gov (United States)

    2013-01-01

    Background Asparagus bean (Vigna. unguiculata. ssp sesquipedalis) is a subspecies and special vegetable type of cowpea (Vigna. unguiculata L. Walp.) important in Asia. Genetic basis of horticulturally important traits of asparagus bean is still poorly understood, hindering the utilization of targeted, DNA marker-assisted breeding in this crop. Here we report the identification of quantitative trait loci (QTLs) and epistatic interactions for four horticultural traits, namely, days to first flowering (FLD), nodes to first flower (NFF), leaf senescence (LS) and pod number per plant (PN) using a recombinant inbred line (RIL) population of asparagus bean. Results A similar genetic mode of one major QTL plus a few minor QTLs was found to dominate each of the four traits, with the number of QTLs for individual traits ranging from three to four. These QTLs were distributed on 7 of the 11 chromosomes. Major QTLs for FLD, NFF and LS were co-localized on LG 11, indicative of tight linkage. Genome wide epistasis analysis detected two and one interactive locus pairs that significantly affect FLD and LS, respectively, and the epistatic QTLs for FLD appeared to work in different ways. Synteny based comparison of QTL locations revealed conservation of chromosome regions controlling these traits in related legume crops. Conclusion Major, minor, and epistatic QTLs were found to contribute to the inheritance of the FLD, NFF, LS, and PN. Positions of many of these QTLs are conserved among closely related legume species, indicating common mechanisms they share. To our best knowledge, this is the first QTL mapping report using an asparagus bean × asparagus bean intervarietal population and provides marker-trait associations for marker-assisted approaches to selection. PMID:23375055

  13. The origin of human complex diversity: Stochastic epistatic modules and the intrinsic compatibility between distributional robustness and phenotypic changeability.

    Science.gov (United States)

    Ijichi, Shinji; Ijichi, Naomi; Ijichi, Yukina; Imamura, Chikako; Sameshima, Hisami; Kawaike, Yoichi; Morioka, Hirofumi

    2018-01-01

    The continuing prevalence of a highly heritable and hypo-reproductive extreme tail of a human neurobehavioral quantitative diversity suggests the possibility that the reproductive majority retains the genetic mechanism for the extremes. From the perspective of stochastic epistasis, the effect of an epistatic modifier variant can randomly vary in both phenotypic value and effect direction among the careers depending on the genetic individuality, and the modifier careers are ubiquitous in the population distribution. The neutrality of the mean genetic effect in the careers warrants the survival of the variant under selection pressures. Functionally or metabolically related modifier variants make an epistatic network module and dozens of modules may be involved in the phenotype. To assess the significance of stochastic epistasis, a simplified module-based model was employed. The individual repertoire of the modifier variants in a module also participates in the genetic individuality which determines the genetic contribution of each modifier in the career. Because the entire contribution of a module to the phenotypic outcome is consequently unpredictable in the model, the module effect represents the total contribution of the related modifiers as a stochastic unit in the simulations. As a result, the intrinsic compatibility between distributional robustness and quantitative changeability could mathematically be simulated using the model. The artificial normal distribution shape in large-sized simulations was preserved in each generation even if the lowest fitness tail was un-reproductive. The robustness of normality beyond generations is analogous to the real situations of human complex diversity including neurodevelopmental conditions. The repeated regeneration of the un-reproductive extreme tail may be inevitable for the reproductive majority's competence to survive and change, suggesting implications of the extremes for others. Further model-simulations to

  14. Type I supergravity effective action from pure spinor formalism

    International Nuclear Information System (INIS)

    Alencar, Geova

    2009-01-01

    Using the pure spinor formalism, we compute the tree-level correlation functions for three strings, one closed and two open, in N = 1 D = 10 superspace. Expanding the superfields in components, the respective terms of the effective action for the type I supergravity are obtained. All terms found agree with the effective action known in the literature. This result gives one more consistency test for the pure spinor formalism.

  15. Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 × DISC1.

    Science.gov (United States)

    O'Tuathaigh, Colm M P; Fumagalli, Fabio; Desbonnet, Lieve; Perez-Branguli, Francesc; Moloney, Gerard; Loftus, Samim; O'Leary, Claire; Petit, Emilie; Cox, Rachel; Tighe, Orna; Clarke, Gerard; Lai, Donna; Harvey, Richard P; Cryan, John F; Mitchell, Kevin J; Dinan, Timothy G; Riva, Marco A; Waddington, John L

    2017-01-01

    Few studies have addressed likely gene × gene (ie, epistatic) interactions in mediating risk for schizophrenia. Using a preclinical genetic approach, we investigated whether simultaneous disruption of the risk factors Neuregulin-1 (NRG1) and Disrupted-in-schizophrenia 1 (DISC1) would produce a disease-relevant phenotypic profile different from that observed following disruption to either gene alone. NRG1 heterozygotes exhibited hyperactivity and disruption to prepulse inhibition, both reversed by antipsychotic treatment, and accompanied by reduced striatal dopamine D2 receptor protein expression, impaired social cognition, and altered glutamatergic synaptic protein expression in selected brain areas. Single gene DISC1 mutants demonstrated a disruption in social cognition and nest-building, altered brain 5-hydroxytryptamine levels and hippocampal ErbB4 expression, and decreased cortical expression of the schizophrenia-associated microRNA miR-29b. Co-disruption of DISC1 and NRG1, indicative of epistasis, evoked an impairment in sociability and enhanced self-grooming, accompanied by changes in hypothalamic oxytocin/vasopressin gene expression. The findings indicate specific behavioral correlates and underlying cellular pathways downstream of main effects of DNA variation in the schizophrenia-associated genes NRG1 and DISC1. © The Author 2016. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  16. Epigenetic and epistatic interactions between serotonin transporter and brain-derived neurotrophic factor genetic polymorphism: insights in depression.

    Science.gov (United States)

    Ignácio, Z M; Réus, G Z; Abelaira, H M; Quevedo, J

    2014-09-05

    Epidemiological studies have shown significant results in the interaction between the functions of brain-derived neurotrophic factor (BDNF) and 5-HT in mood disorders, such as major depressive disorder (MDD). The latest research has provided convincing evidence that gene transcription of these molecules is a target for epigenetic changes, triggered by stressful stimuli that starts in early childhood and continues throughout life, which are subsequently translated into structural and functional phenotypes culminating in depressive disorders. The short variants of 5-HTTLPR and BDNF-Met are seen as forms which are predisposed to epigenetic aberrations, which leads individuals to a susceptibility to environmental adversities, especially when subjected to stress in early life. Moreover, the polymorphic variants also feature epistatic interactions in directing the functional mechanisms elicited by stress and underlying the onset of depressive disorders. Also emphasized are works which show some mediators between stress and epigenetic changes of the 5-HTT and BDNF genes, such as the hypothalamic-pituitary-adrenal (HPA) axis and the cAMP response element-binding protein (CREB), which is a cellular transcription factor. Both the HPA axis and CREB are also involved in epistatic interactions between polymorphic variants of 5-HTTLPR and Val66Met. This review highlights some research studying changes in the epigenetic patterns intrinsic to genes of 5-HTT and BDNF, which are related to lifelong environmental adversities, which in turn increases the risks of developing MDD. Copyright © 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

  17. Both epistatic and additive effects of QTLs are involved in polygenic induced resistance to disease: a case study, the interaction pepper - Phytophthora capsici Leonian.

    Science.gov (United States)

    Lefebvre, V; Palloix, A

    1996-09-01

    To study the resistance of pepper to Phytophthora capsici, we analyzed 94 doubled-haploid (DH) lines derived from the intraspecific F1 hybrid obtained from a cross between Perennial, an Indian pungent resistant line, and Yolo Wonder, an American bell-pepper susceptible line, with 119 DNA markers. Four different criteria were used to evaluate the resistance, corresponding to different steps or mechanisms of the host-pathogen interaction: root-rot index, receptivity, inducibility and stability. Three distinct ANOVA models between DNA marker genotypes and the four disease criteria identified 13 genomic regions, distributed across several linkage groups or unlinked markers, affecting the resistance of pepper to P. capsici. Some QTLs were criterion specific, whereas others affect several criteria, so that the four resistance criteria were controlled by different combinations of QTLs. The QTLs were very different in their quantitative effect (R(2) values), including major QTLs which explained 41-55% of the phenotypic variance, intermediate QTLs with additive or/and epistatic action (17-28% of the variance explained) and minor QTLs. Favourable alleles of some minor QTLs were carried in the susceptible parent. The total phenotypic variation accounted for by QTLs reached up to 90% for receptivity, with an important part due to epistasis effects between QTLs (with or without additive effects). The relative impact of resistance QTLs in disease response is discussed.

  18. Fitness ranking of individual mutants drives patterns of epistatic interactions in HIV-1.

    Directory of Open Access Journals (Sweden)

    Javier P Martínez

    Full Text Available Fitness interactions between mutations, referred to as epistasis, can strongly impact evolution. For RNA viruses and retroviruses with their high mutation rates, epistasis may be particularly important to overcome fitness losses due to the accumulation of deleterious mutations and thus could influence the frequency of mutants in a viral population. As human immunodeficiency virus type 1 (HIV-1 resistance to azidothymidine (AZT requires selection of sequential mutations, it is a good system to study the impact of epistasis. Here we present a thorough analysis of a classical AZT-resistance pathway (the 41-215 cluster of HIV-1 variants by fitness measurements in single round infection assays covering physiological drug concentrations ex vivo. The sign and value of epistasis varied and did not predict the epistatic effect on the mutant frequency. This complex behavior is explained by the fitness ranking of the variants that strongly depends on environmental factors, i.e., the presence and absence of drugs and the host cells used. Although some interactions compensate fitness losses, the observed small effect on the relative mutant frequencies suggests that epistasis might be inefficient as a buffering mechanism for fitness losses in vivo. While the use of epistasis-based hypotheses to make general assumptions on the evolutionary dynamics of viral populations is appealing, our data caution their interpretation without further knowledge on the characteristics of the viral mutant spectrum under different environmental conditions.

  19. Effect of microcrystallization on pitting corrosion of pure aluminium

    International Nuclear Information System (INIS)

    Meng Guozhe; Wei Liyan; Zhang Tao; Shao Yawei; Wang Fuhui; Dong Chaofang; Li Xiaogang

    2009-01-01

    A microcrystalline aluminium film with grain size of about 400 nm was prepared by magnetron sputtering technique. Its corrosion behaviour was investigated in NaCl containing acidic solution by means of potentiodynamic polarization curves and electrochemical noise (EN). The polarization results indicated that the corrosion potential of the sample shifted towards more positive direction, while its corrosion current density decreased compared with that of pure coarse-grain Al. The EN analysis based on stochastic model demonstrated that there existed two kinds of effect of microcrystallization on the pitting behaviour of pure aluminium: (1) the rate of pit initiation is accelerated, (2) the pit growth process was impeded. This leads to the enhancement of pitting resistance for the microcrystallized aluminium.

  20. Yttrium implantation effects on extra low carbon steel and pure iron

    Energy Technology Data Exchange (ETDEWEB)

    Caudron, E.; Buscail, H. [Clermont-Ferrand-2 Univ., Le Puy en Velay (France). Lab. Vellave d`Elaboration; Jacob, Y.P.; Stroosnijder, M.F. [Institute for Advanced Materials, Joint Research Center, The European Commission, 21020, Ispra (Vatican City State, Holy See) (Italy); Josse-Courty, C. [Laboratoire de Recherche sur la Reactivite des Solides, UMR 56-13 CNRS, UFR Sciences et Techniques, 9 Avenue A. Savary, B.P. 400, 21011, Dijon Cedex (France)

    1999-05-25

    Extra low carbon steel and pure electrolytic iron samples were yttrium implanted using ion implantation technique. Compositions and structures of pure iron and steel samples were investigated before and after yttrium implantation by several analytical and structural techniques (RBS, SIMS, RHEED and XRD) to observe the yttrium implantation depth profiles in the samples. This paper shows the different effects of yttrium implantations (compositions and structures) according to the implanted sample nature. (orig.) 23 refs.

  1. Dissociative effects of orthographic distinctiveness in pure and mixed lists: an item-order account.

    Science.gov (United States)

    McDaniel, Mark A; Cahill, Michael; Bugg, Julie M; Meadow, Nathaniel G

    2011-10-01

    We apply the item-order theory of list composition effects in free recall to the orthographic distinctiveness effect. The item-order account assumes that orthographically distinct items advantage item-specific encoding in both mixed and pure lists, but at the expense of exploiting relational information present in the list. Experiment 1 replicated the typical free recall advantage of orthographically distinct items in mixed lists and the elimination of that advantage in pure lists. Supporting the item-order account, recognition performances indicated that orthographically distinct items received greater item-specific encoding than did orthographically common items in mixed and pure lists (Experiments 1 and 2). Furthermore, order memory (input-output correspondence and sequential contiguity effects) was evident in recall of pure unstructured common lists, but not in recall of unstructured distinct lists (Experiment 1). These combined patterns, although not anticipated by prevailing views, are consistent with an item-order account.

  2. Derivation of the pure Faraday and Cotton-Mouton effects when polarimetric effects in a tokamak are large

    International Nuclear Information System (INIS)

    Segre, S E; Zanza, V

    2006-01-01

    When polarimetric effects are large the Cotton-Mouton and Faraday effects do not combine linearly and it is not possible to separate exactly the pure Cotton-Mouton effect W 1 and the pure Faraday effect, W 3 . Four alternative approximate expressions for W 1 and W 3 in terms of measurable quantities are examined for tokamak configurations. Two of these approximations proposed recently are found to be preferable, some previous statements concerning them are corrected and the errors incurred by their use are evaluated

  3. Exact effective actions for quarks in pure and self-dual mean fields

    International Nuclear Information System (INIS)

    Elizalde, E.; Soto, J.

    1985-01-01

    The QCD effective action for ordinary quarks in the presence of a constant self-dual, pure colormagnetic or pure color-electric background created by themselves is calculated at all loop orders. This is done in a very simple way, by using zeta-function regularization and the fact that the dependence of the effective action on the background can be factorized in these three cases, leaving a well-defined constant factor. The zero mode problem and the imaginary contributions are seen to be mere one-loop artifacts which automatically vanish when the exact calculation is carried out. (orig.)

  4. Effect of Equal-Channel Angular Pressing on Pitting Corrosion of Pure Aluminum

    Directory of Open Access Journals (Sweden)

    Injoon Son

    2012-01-01

    Full Text Available The effect of equal-channel angular pressing (ECAP on the pitting corrosion of pure Al was investigated using electrochemical techniques in solutions containing 0.1 m mol·dm−3 of Na2SO4 and 8.46 mol·dm−3 of NaCl (300 ppm Cl− and followed by surface analysis. The potential for pitting corrosion of pure Al was clearly shifted in the noble direction by the ECAP process indicating that this process improves resistance to pitting corrosion. The time dependence of corrosion potential and the anodic potential at 1 A·m−2 revealed that the rate of formation of Al oxide films increased due to a decrease in the grain size of the Al after ECAP. Since there exists a negligible amount of impurity precipitates in pure Al, the improvement in pitting corrosion resistance of pure Al by ECAP appears to be attributable to an increase in the rate of formation of Al oxide films.

  5. Effect of Heat Treatment on the Lycopene Content of Tomato Puree ...

    African Journals Online (AJOL)

    Effect of Heat Treatment on the Lycopene Content of Tomato Puree. MI Mohammed, DI Malami. Abstract. Lycopene is a powerful antioxidant. Epidemiological studies have associated its consumption with numerous health benefits. In this study the effects of heating on lycopene were investigated by exposing tomato ...

  6. Musical notation reading in pure alexia

    DEFF Research Database (Denmark)

    Starrfelt, Randi; Wong, Yetta K.

    2017-01-01

    Pure alexia (PA) is an acquired reading disorder following lesions to left ventral temporo-occipital cortex. Patients with PA read slowly but correctly, and show an abnormal effect of word length on RTs. However, it is unclear how pure alexia may affect musical notation reading. We report a pure...

  7. An epistatic interaction between the PAX8 and STK17B genes in papillary thyroid cancer susceptibility.

    Directory of Open Access Journals (Sweden)

    Iñigo Landa

    Full Text Available Papillary Thyroid Cancer (PTC is a heterogeneous and complex disease; susceptibility to PTC is influenced by the joint effects of multiple common, low-penetrance genes, although relatively few have been identified to date. Here we applied a rigorous combined approach to assess both the individual and epistatic contributions of genetic factors to PTC susceptibility, based on one of the largest series of thyroid cancer cases described to date. In addition to identifying the involvement of TSHR variation in classic PTC, our pioneer study of epistasis revealed a significant interaction between variants in STK17B and PAX8. The interaction was detected by MD-MBR (p = 0.00010 and confirmed by other methods, and then replicated in a second independent series of patients (MD-MBR p = 0.017. Furthermore, we demonstrated an inverse correlation between expression of PAX8 and STK17B in a set of cell lines derived from human thyroid carcinomas. Overall, our work sheds additional light on the genetic basis of thyroid cancer susceptibility, and suggests a new direction for the exploration of the inherited genetic contribution to disease using association studies.

  8. The effect of pure state structure on nonequilibrium dynamics

    International Nuclear Information System (INIS)

    Newman, C M; Stein, D L

    2008-01-01

    Motivated by short-range Ising spin glasses, we review some rigorous results and their consequences for the relation between the number/nature of equilibrium pure states and nonequilibrium dynamics. Two of the consequences for spin glass dynamics following an instantaneous deep quench to a temperature with broken spin flip symmetry are: (1) almost all initial configurations lie on the boundary between the basins of attraction of multiple pure states; (2) unless there are uncountably many pure states with almost all pairs having zero overlap, there can be no equilibration to a pure state as time t → ∞. We discuss the relevance of these results to the difficulty of equilibration of spin glasses. We also review some results concerning the 'nature versus nurture' problem of whether the large-t behavior of both ferromagnets and spin glasses following a deep quench is determined more by the initial configuration (nature) or by the dynamics realization (nurture)

  9. Understanding the effects of lignosulfonate on enzymatic saccharification of pure cellulose

    Science.gov (United States)

    Hongming Lou; Haifeng Zhou; Xiuli Li; Mengxia Wang; J.Y. Zhu; Xueqing Qiu

    2014-01-01

    The effects of lignosulfonate (LS) on enzymatic saccharification of pure cellulose were studied. Four fractions of LS with different molecular weight (MW) prepared by ultrafiltration of a commercial LS were applied at different loadings to enzymatic hydrolysis of Whatman paper under different pH. Using LS fractions with low MW and high degree of sulfonation can enhance...

  10. PSYCHE Pure Shift NMR Spectroscopy.

    Science.gov (United States)

    Foroozandeh, Mohammadali; Morris, Gareth; Nilsson, Mathias

    2018-03-13

    Broadband homodecoupling techniques in NMR, also known as "pure shift" methods, aim to enhance spectral resolution by suppressing the effects of homonuclear coupling interactions to turn multiplet signals into singlets. Such techniques typically work by selecting a subset of "active" nuclear spins to observe, and selectively inverting the remaining, "passive", spins to reverse the effects of coupling. Pure Shift Yielded by Chirp Excitation (PSYCHE) is one such method; it is relatively recent, but has already been successfully implemented in a range of different NMR experiments. Paradoxically, PSYCHE is one of the trickiest of pure shift NMR techniques to understand but one of the easiest to use. Here we offer some insights into theoretical and practical aspects of the method, and into the effects and importance of the experimental parameters. Some recent improvements that enhance the spectral purity of PSYCHE spectra will be presented, and some experimental frameworks including examples in 1D and 2D NMR spectroscopy, for the implementation of PSYCHE will be introduced. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Tractable Quantification of Entanglement for Multipartite Pure States

    International Nuclear Information System (INIS)

    Nian-Quan, Jiang; Yu-Jian, Wang; Yi-Zhuang, Zheng; Gen-Chang, Cai

    2008-01-01

    We present kth-order entanglement measure and global kth-order entanglement measure for multipartite pure states, and extend Bennett's measure of partial entropy for bipartite pure states to a multipartite case. These measures are computable and can effectively classify and quantify the entanglement of multipartite pure states. (general)

  12. Effect of sterilization process on surface characteristics and biocompatibility of pure Mg and MgCa alloys

    International Nuclear Information System (INIS)

    Liu, X.L.; Zhou, W.R.; Wu, Y.H.; Cheng, Y.; Zheng, Y.F.

    2013-01-01

    The aim of this work was to investigate the effect of various sterilization methods on surface characteristics and biocompatibility of MgCa alloy, with pure Mg as a comparison, including steam autoclave sterilization (SA), ethylene oxide steam sterilization (EO), glutaraldehyde sterilization (GD), dry heat sterilization (DH) and Co60 γ ray radiation sterilization (R) technologies. The surface characterizations were performed by environmental scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, grazing incidence X-ray diffraction, water contact angle and surface free energy measurement, whereas the cytotoxicity and hemocompatibility were evaluated by cellular adhesive experiment, platelet adhesion and hemolysis test. The results showed that the five sterilization processes caused more changes on the surface of MgCa alloy than that on the surface of pure Mg. The GD sterilization caused the most obvious changes on the surface of the pure Mg, and the SA sterilization made the largest alteration on the MgCa alloy surface. The GD and DH sterilization processes could cause increases on surface free energy for both pure Mg and MgCa alloys, while the other three sterilization processes reduced the surface free energy. The DH and GD sterilization processes caused the least alteration on the cell adhesion on pure Mg surface, whereas the EO sterilization performed the greatest impact on the cell adhesion on the Mg–Ca alloy surface. The hemolysis percentage of pure Mg and MgCa alloys were reduced by SA sterilization, meanwhile the other four sterilization processes increased their hemolysis percentages significantly, especially for the EO sterilization. - Highlights: • The effect of sterilization on surface chemistry and biocompatibility was studied. • Sterilization caused more surface changes on MgCa alloy than pure Mg. • Co60 γ ray radiation is the most appropriate sterilization process

  13. Multi-location wheat stripe rust QTL analysis: genetic background and epistatic interactions.

    Science.gov (United States)

    Vazquez, M Dolores; Zemetra, Robert; Peterson, C James; Chen, Xianming M; Heesacker, Adam; Mundt, Christopher C

    2015-07-01

    Epistasis and genetic background were important influences on expression of stripe rust resistance in two wheat RIL populations, one with resistance conditioned by two major genes and the other conditioned by several minor QTL. Stripe rust is a foliar disease of wheat (Triticum aestivum L.) caused by the air-borne fungus Puccinia striiformis f. sp. tritici and is present in most regions around the world where commercial wheat is grown. Breeding for durable resistance to stripe rust continues to be a priority, but also is a challenge due to the complexity of interactions among resistance genes and to the wide diversity and continuous evolution of the pathogen races. The goal of this study was to detect chromosomal regions for resistance to stripe rust in two winter wheat populations, 'Tubbs'/'NSA-98-0995' (T/N) and 'Einstein'/'Tubbs' (E/T), evaluated across seven environments and mapped with diversity array technology and simple sequence repeat markers covering polymorphic regions of ≈1480 and 1117 cM, respectively. Analysis of variance for phenotypic data revealed significant (P located in chromosomes 2AS and 6AL, with epistatic interaction between them, were responsible for the main phenotypic response. For the T/N population, eight QTL were identified, with those in chromosomes 2AL and 2BL accounting for the largest percentage of the phenotypic variance.

  14. Rote Rehearsal and Spacing Effects in the Free Recall of Pure and Mixed Lists

    Science.gov (United States)

    Verkoeijen, Peter P. J. L.; Delaney, Peter F.

    2008-01-01

    The "spacing effect" is the commonly observed phenomenon that memory for spaced repetitions is better than memory for massed repetitions. To further investigate the role of rehearsal in spacing effects, three experiments were conducted. With pure lists we found spacing effects in free recall when spacing intervals were relatively long (Experiments…

  15. A novel epistatic interaction at two loci causing hybrid male sterility in an inter-subspecific cross of rice (Oryza sativa L.).

    Science.gov (United States)

    Kubo, Takahiko; Yamagata, Yoshiyuki; Eguchi, Maki; Yoshimura, Atsushi

    2008-12-01

    Postzygotic reproductive isolation (RI) often arises in inter-subspecific crosses as well as inter-specific crosses of rice (Oryza sativa L.). To further understand the genetic architecture of the postzygotic RI, we analyzed genes causing hybrid sterility and hybrid breakdown in a rice inter-subspecific cross. Here we report hybrid male sterility caused by epistatic interaction between two novel genes, S24 and S35, which were identified on rice chromosomes 5 and 1, respectively. Genetic analysis using near-isogenic lines (NILs) carrying IR24 (ssp. indica) segments with Asominori (ssp. japonica) genetic background revealed a complicated aspect of the epistasis. Allelic interaction at the S24 locus in the heterozygous plants caused abortion of male gametes carrying the Asominori allele (S24-as) independent of the S35 genotype. On the other hand, male gametes carrying the Asominori allele at the S35 locus (S35-as) showed abortion only when the IR24 allele at the S24 locus (S24-ir) was concurrently introgressed into the S35 heterozygous plants, indicating that the sterility phenotype due to S35 was dependent on the S24 genotype through negative epistasis between S24-ir and S35-as alleles. Due to the interaction between S24 and S35, self-pollination of the double heterozygous plants produced pollen-sterile progeny carrying the S24-ir/S24-ir S35-as/S35-ir genotype in addition to the S24 heterozygous plants. This result suggests that the S35 gene might function as a modifier of S24. This study presents strong evidence for the importance of epistatic interaction as a part of the genetic architecture of hybrid sterility in rice. In addition, it suggests that diverse systems have been developed as postzygotic RI mechanisms within the rice.

  16. Effect of Bound Entanglement on the Convertibility of Pure States

    International Nuclear Information System (INIS)

    Ishizaka, Satoshi

    2004-01-01

    I show that bound entanglement strongly influences the quantum entanglement processing of pure states: If N distant parties share appropriate bound entangled states with positive partial transpose, all N-partite pure entangled states become inter-convertible by stochastic local operations and classical communication (SLOCC) at the single copy level. This implies that the Schmidt rank of a bipartite pure entangled state can be increased, and that two incomparable tripartite entanglement of the GHZ and W type can be inter-converted by the assistance of bound entanglement. Further, I propose the simplest experimental scheme for the demonstration of the corresponding bound-entanglement-assisted SLOCC. This scheme does not need quantum gates and is feasible for the current experimental technology of linear optics

  17. Pure contagion effects in international banking: The case of BCCI’s failure

    OpenAIRE

    Angelos Kanas

    2005-01-01

    We test for pure contagion effects in international banking arising from the failure of the Bank of Credit and Commerce International (BCCI), one of the largest bank failures in the world. We focused on large individual banks in three developed countries where BCCI had established operations, namely the UK, the US, and Canada. Using event study methodology, we tested for contagion effects using time windows surrounding several known BCCI-related announcements. Our analysis provides strong evi...

  18. Rehabilitation of pure alexia

    DEFF Research Database (Denmark)

    Starrfelt, Randi; Ólafsdóttir, Rannveig Rós; Arendt, Ida-Marie

    2013-01-01

    that pure alexia was an easy target for rehabilitation efforts. We review the literature on rehabilitation of pure alexia from 1990 to the present, and find that patients differ widely on several dimensions like alexia severity, and associated deficits. Many patients reported to have pure alexia......-designed and controlled studies of rehabilitation of pure alexia....

  19. Annealing Effect on Mechanical Properties of Ti-Al Alloy/Pure Ti Harmonic-Structured Composite by MM/SPS Process

    International Nuclear Information System (INIS)

    Yoshida, R; Tsuda, T; Fujiwara, H; Miyamoto, H; Ameyama, K

    2014-01-01

    The Ti-Al alloy/pure Ti harmonic-structured composite was produced by mechanical milling and spark plasma sintering process for improvement of low ductility at room temperature of Ti-Al alloy. The harmonic-structured composite with the dispersed area having coarse grained titanium and the network area having fine-grained Ti-48mol%Al alloy demonstrates high strength and high ductility at room temperature. The annealing effect of the microstructure on the mechanical properties in the Ti-Al alloy/pure Ti harmonic-structured composite are investigated. The microstructure of the Ti-Al alloy/pure Ti harmonic-structured composite annealed at 873 K, 973 K and 1073 K are maintained the Ti-Al network structure and pure Ti dispersed regions, the average grain size of pure Ti dispersed region is only coarsen by annealing. The harmonic-structured composite annealed at 873 K, 973 K and 1073 K are maintained the high hardness. The tensile results reveal that the Ti-Al alloy/pure Ti harmonic- structured composite annealed at 873 K exhibits high strength and especially high ductility

  20. Effects of grain size on the corrosion resistance of pure magnesium by cooling rate-controlled solidification

    Science.gov (United States)

    Liu, Yichi; Liu, Debao; You, Chen; Chen, Minfang

    2015-09-01

    The aim of this study was to investigate the effect of grain size on the corrosion resistance of pure magnesium developed for biomedical applications. High-purity magnesium samples with different grain size were prepared by the cooling rate-controlled solidification. Electrochemical and immersion tests were employed to measure the corrosion resistance of pure magnesium with different grain size. The electrochemical polarization curves indicated that the corrosion susceptibility increased as the grain size decrease. However, the electrochemical impedance spectroscopy (EIS) and immersion tests indicated that the corrosion resistance of pure magnesium is improved as the grain size decreases. The improvement in the corrosion resistance is attributed to refine grain can produce more uniform and density film on the surface of sample.

  1. Estimation of genetic effects in the presence of multicollinearity in multibreed beef cattle evaluation.

    Science.gov (United States)

    Roso, V M; Schenkel, F S; Miller, S P; Schaeffer, L R

    2005-08-01

    Breed additive, dominance, and epistatic loss effects are of concern in the genetic evaluation of a multibreed population. Multiple regression equations used for fitting these effects may show a high degree of multicollinearity among predictor variables. Typically, when strong linear relationships exist, the regression coefficients have large SE and are sensitive to changes in the data file and to the addition or deletion of variables in the model. Generalized ridge regression methods were applied to obtain stable estimates of direct and maternal breed additive, dominance, and epistatic loss effects in the presence of multicollinearity among predictor variables. Preweaning weight gains of beef calves in Ontario, Canada, from 1986 to 1999 were analyzed. The genetic model included fixed direct and maternal breed additive, dominance, and epistatic loss effects, fixed environmental effects of age of the calf, contemporary group, and age of the dam x sex of the calf, random additive direct and maternal genetic effects, and random maternal permanent environment effect. The degree and the nature of the multicollinearity were identified and ridge regression methods were used as an alternative to ordinary least squares (LS). Ridge parameters were obtained using two different objective methods: 1) generalized ridge estimator of Hoerl and Kennard (R1); and 2) bootstrap in combination with cross-validation (R2). Both ridge regression methods outperformed the LS estimator with respect to mean squared error of predictions (MSEP) and variance inflation factors (VIF) computed over 100 bootstrap samples. The MSEP of R1 and R2 were similar, and they were 3% less than the MSEP of LS. The average VIF of LS, R1, and R2 were equal to 26.81, 6.10, and 4.18, respectively. Ridge regression methods were particularly effective in decreasing the multicollinearity involving predictor variables of breed additive effects. Because of a high degree of confounding between estimates of maternal

  2. Selenistasis: Epistatic Effects of Selenium on Cardiovascular Phenotype

    Directory of Open Access Journals (Sweden)

    Joseph Loscalzo

    2013-01-01

    Full Text Available Although selenium metabolism is intricately linked to cardiovascular biology and function, and deficiency of selenium is associated with cardiac pathology, utilization of selenium in the prevention and treatment of cardiovascular disease remains an elusive goal. From a reductionist standpoint, the major function of selenium in vivo is antioxidant defense via its incorporation as selenocysteine into enzyme families such as glutathione peroxidases and thioredoxin reductases. In addition, selenium compounds are heterogeneous and have complex metabolic fates resulting in effects that are not entirely dependent on selenoprotein expression. This complex biology of selenium in vivo may underlie the fact that beneficial effects of selenium supplementation demonstrated in preclinical studies using models of oxidant stress-induced cardiovascular dysfunction, such as ischemia-reperfusion injury and myocardial infarction, have not been consistently observed in clinical trials. In fact, recent studies have yielded data that suggest that unselective supplementation of selenium may, indeed, be harmful. Interesting biologic actions of selenium are its simultaneous effects on redox balance and methylation status, a combination that may influence gene expression. These combined actions may explain some of the biphasic effects seen with low and high doses of selenium, the potentially harmful effects seen in normal individuals, and the beneficial effects noted in preclinical studies of disease. Given the complexity of selenium biology, systems biology approaches may be necessary to reach the goal of optimization of selenium status to promote health and prevent disease.

  3. Rehearsal Strategies Can Enlarge or Diminish the Spacing Effect: Pure versus Mixed Lists and Encoding Strategy

    Science.gov (United States)

    Delaney, Peter F.; Verkoeijen, Peter P. J. L.

    2009-01-01

    Using 5 experiments, the authors explored the dependency of spacing effects on rehearsal patterns. Encouraging rehearsal borrowing produced opposing effects on mixed lists (containing both spaced and massed repetitions) and pure lists (containing only one or the other), magnifying spacing effects on mixed lists but diminishing spacing effects on…

  4. The effect of oil pulling with pure coconut oil on Streptococcus mutans: A randomized controlled trial

    OpenAIRE

    Varsha Komath Pavithran; Madhusudhan Krishna; Vinod A Kumar; Ashish Jaiswal; Arul K Selvan; Sudhir Rawlani

    2017-01-01

    Introduction: Oil pulling as described in ancient Ayurveda involves the use of edible vegetable oils as oral antibacterial agents. It is a practice of swishing oil in the mouth for oral and systemic health benefits. Pure coconut oil has antimicrobial properties and is commonly available in all Indian households. Aim: This study aims to assess the effect of oil pulling therapy with pure coconut oil on Streptococcus mutans count and to compare its efficacy against sesame oil and saline. Materia...

  5. How Low Can You Go: Spatial Frequency Sensitivity in Pure Alexia

    DEFF Research Database (Denmark)

    Starrfelt, Randi; Nielsen, S.; Habekost, T.

    Objective: Pure alexia is a seemingly selective deficit in reading, follow- ing focal lesions to the posterior left hemisphere. The hallmark feature of pure alexia is a word length effect in single word reading, where reaction times may increase with hundreds of milliseconds per additional letter...... in a word. Other language functions, including writing, are intact. It has been suggested that pure alexia is caused by a general deficit in visual processing, one that affects reading disproportionally compared to other visual stimuli. The most concrete hypothesis to date suggests that pure alexia...... is caused by a lack of sensitivity to particular spatial frequencies (e.g., Fiset et al., 2006), and that this results in the characteristic word length effect, as well as effects of letter confusability on reading times. Participants and Methods: We have tested this hypothesis in a patient with pure alexia...

  6. Color Spectrum Properties of Pure and Non-Pure LATEX in Discriminating Rubber Clone Series

    International Nuclear Information System (INIS)

    Noor Aishah Khairuzzaman; Hadzli Hashim; Nina Korlina Madzhi; Noor Ezan Abdullah; Faridatul Aima Ismail; Ahmad Faiz Sampian; Azhana Fatnin Che Will

    2015-01-01

    A study of color spectrum properties for pure and non-pure latex in discriminating rubber clone series has been presented in this paper. There were five types of clones from the same series being used as samples in this study named RRIM2002, RRIM2007, RRIM2008, RRIM2014, and RRIM3001. The main objective is to identify the significant color spectrum (RGB) from pure and non-pure latex that can discriminate rubber clone series. The significant information of color spectrum properties for pure and non-pure latex is determined by using spectrometer and Statistical Package for the Social Science (SPSS). Visible light spectrum (VIS) is used as a radiation light of the spectrometer to emit light to the surface of the latex sample. By using SPSS software, the further numerical analysis of color spectrum properties is being conducted. As the conclusion, blue color spectrum for non-pure is able to discriminate for all rubber clone series whereas only certain color spectrum can differentiate several clone series for pure latex. (author)

  7. CRISPR Perturbation of Gene Expression Alters Bacterial Fitness under Stress and Reveals Underlying Epistatic Constraints.

    Science.gov (United States)

    Otoupal, Peter B; Erickson, Keesha E; Escalas-Bordoy, Antoni; Chatterjee, Anushree

    2017-01-20

    The evolution of antibiotic resistance has engendered an impending global health crisis that necessitates a greater understanding of how resistance emerges. The impact of nongenetic factors and how they influence the evolution of resistance is a largely unexplored area of research. Here we present a novel application of CRISPR-Cas9 technology for investigating how gene expression governs the adaptive pathways available to bacteria during the evolution of resistance. We examine the impact of gene expression changes on bacterial adaptation by constructing a library of deactivated CRISPR-Cas9 synthetic devices to tune the expression of a set of stress-response genes in Escherichia coli. We show that artificially inducing perturbations in gene expression imparts significant synthetic control over fitness and growth during stress exposure. We present evidence that these impacts are reversible; strains with synthetically perturbed gene expression regained wild-type growth phenotypes upon stress removal, while maintaining divergent growth characteristics under stress. Furthermore, we demonstrate a prevailing trend toward negative epistatic interactions when multiple gene perturbations are combined simultaneously, thereby posing an intrinsic constraint on gene expression underlying adaptive trajectories. Together, these results emphasize how CRISPR-Cas9 can be employed to engineer gene expression changes that shape bacterial adaptation, and present a novel approach to synthetically control the evolution of antimicrobial resistance.

  8. [Effects of laser welding on bond of porcelain fused cast pure titanium].

    Science.gov (United States)

    Zhu, Juan-fang; He, Hui-ming; Gao, Bo; Wang, Zhong-yi

    2006-04-01

    To investigate the influence of the laser welding on bond of porcelain fused to cast pure titanium. Twenty cast titanium plates were divided into two groups: laser welded group and control group. The low-fusing porcelain was fused to the laser welded cast pure titanium plates at fusion zone. The bond strength of the porcelain to laser welded cast pure titanium was measured by the three-point bending test. The interface of titanium and porcelain was investigated by scanning electron microscopy (SEM) and energy depressive X-ray detector (EDX). The non-welded titanium plates were used as comparison. No significant difference of the bond strength was found between laser-welded samples [(46.85 +/- 0.76) MPa] and the controls [(41.71 +/- 0.55) MPa] (P > 0.05). The SEM displayed the interface presented similar irregularities with a predominance. The titanium diffused to low-fusing porcelain, while silicon and aluminum diffused to titanium basement. Laser welding does not affect low-fusing porcelain fused to pure titanium.

  9. Effect of gamma irradiation and storage time on microbial growth and physicochemical characteristics of pumpkin (Cucurbita Moschata Duchesne ex Poiret) puree.

    Science.gov (United States)

    Gliemmo, María F; Latorre, María E; Narvaiz, Patricia; Campos, Carmen A; Gerschenson, Lía N

    2014-01-01

    The effect of gamma irradiation (0-2 kGy) and storage time (0-28 days) on microbial growth and physicochemical characteristics of a packed pumpkin puree was studied. For that purpose, a factorial design was applied. The puree contained potassium sorbate, glucose and vanillin was stored at 25°C . Gamma irradiation diminished and storage time increased microbial growth. A synergistic effect between both variables on microbial growth was observed. Storage time decreased pH and color of purees. Sorbate content decreased with storage time and gamma irradiation. Mathematical models of microbial growth generated by the factorial design allowed estimating that a puree absorbing 1.63 kGy would have a shelf-life of 4 days. In order to improve this time, some changes in the applied hurdles were assayed. These included a thermal treatment before irradiation, a reduction of irradiation dose to 0.75 kGy and a decrease in storage temperature at 20°C . As a result, the shelf-life of purees increased to 28 days.

  10. Sixth form pure mathematics

    CERN Document Server

    Plumpton, C

    1968-01-01

    Sixth Form Pure Mathematics, Volume 1, Second Edition, is the first of a series of volumes on Pure Mathematics and Theoretical Mechanics for Sixth Form students whose aim is entrance into British and Commonwealth Universities or Technical Colleges. A knowledge of Pure Mathematics up to G.C.E. O-level is assumed and the subject is developed by a concentric treatment in which each new topic is used to illustrate ideas already treated. The major topics of Algebra, Calculus, Coordinate Geometry, and Trigonometry are developed together. This volume covers most of the Pure Mathematics required for t

  11. Similarities and differences between learning abilities, "pure" learning disabilities, "pure" ADHD and comorbid ADHD with learning disabilities.

    Science.gov (United States)

    Mangina, Constantine A; Beuzeron-Mangina, Helen

    2009-08-01

    This research pursues the crucial question of the differentiation of preadolescents with "Pure" ADHD, comorbid ADHD with learning disabilities, "Pure" learning disabilities and age-matched normal controls. For this purpose, Topographic Mapping of Event-Related Brain Potentials (ERPs) to a Memory Workload Paradigm with visually presented words, Bilateral Electrodermal Activity during cognitive workload and Mangina-Test performance were used. The analysis of Topographic distribution of amplitudes revealed that normal preadolescents were significantly different from "Pure" ADHD (Plearning disabilities (Plearning disabilities (Plearning disabilities have shown a marked reduction of prefrontal and frontal negativities (N450). As for the "Pure" Learning Disabled preadolescents, very small positivities (P450) in prefrontal and frontal regions were obtained as compared to the other pathological groups. Bilateral Electrodermal Activity during cognitive workload revealed a significant main effect for groups (P<0.00001), Left versus Right (P=0.0029) and sessions (P=0.0136). A significant main effect for the Mangina-Test performance which separated the four groups was found (P<0.000001). Overall, these data support the existence of clear differences and similarities between the pathological preadolescent groups as opposed to age-matched normal controls. The psychophysiological differentiation of these groups, provides distinct biological markers which integrate central, autonomic and neuropsychometric variables by targeting the key features of these pathologies for diagnosis and intervention strategies and by providing knowledge for the understanding of normal neurocognitive processes and functions.

  12. Non-critical pure spinor superstrings

    International Nuclear Information System (INIS)

    Adam, Ido; Grassi, Pietro Antonio; Mazzucato, Luca; Oz, Yaron; Yankielowicz, Shimon

    2007-01-01

    We construct non-critical pure spinor superstrings in two, four and six dimensions. We find explicitly the map between the RNS variables and the pure spinor ones in the linear dilaton background. The RNS variables map onto a patch of the pure spinor space and the holomorphic top form on the pure spinor space is an essential ingredient of the mapping. A basic feature of the map is the requirement of doubling the superspace, which we analyze in detail. We study the structure of the non-critical pure spinor space, which is different from the ten-dimensional one, and its quantum anomalies. We compute the pure spinor lowest lying BRST cohomology and find an agreement with the RNS spectra. The analysis is generalized to curved backgrounds and we construct as an example the non-critical pure spinor type IIA superstring on AdS 4 with RR 4-form flux

  13. UV Irradiation Effects in Pure and Tin-Doped Amorphous AsSe Films

    Science.gov (United States)

    2001-06-01

    during irradiation did not exceed 40 ’C. 304 M. Popescu, M. lovu, W. Hloyer, 0. Shpotyuk , F. Sava, A. L6rinczi 3. Results Pure and tin-doped AsSe filns...9000 ,- ,, ---, ,, - ,, - 9000 .... ... .-.. .. r111h) (222) Illuminated 8000 8000 - 7000 7000 lie (220) 6000 6000 5000 O 5000 4000 - 4000 3000 .L...Popescu, M. lovu, W. Hoyer, 0. Shpotyuk , F. Sava, A. L6rinczi the effective thickness of the layers and, possibly, the correlation length. The photo

  14. Effect Of Gamma Irradiation On Microbiological Properties Of Frozen Durian Pulp And Puree

    International Nuclear Information System (INIS)

    Sofian Ibrahim; Cosmos, George; Noor Hasni Mohd Ali; Zarina Mohd Nor; Syuhadah Ramli; Jamilah Karim; Ahsanulkhaliqin Abdul Wahab; Mohd Khairul Azfar Ramli; Mohd Sidek Othman

    2013-01-01

    Studies on effects of gamma irradiation on the frozen Durian fruit (Durio zibethinus Murray) was conducted in MINTec-Sinagama, Malaysian Nuclear Agency, using a Co-60 source. The main aims of the study were to determine the optimum range of gamma irradiation dose can be applied on frozen durian pulp and puree to improve the microbial quality whilst maintaining its flavor. The results showed that the generic gamma radiation dose between 2 kGy until 6 kGy can reduced total plate count (TPC) of the recorded initial TPC values of fresh durian pulp and puree; 6.10 x 10 5 and 3.79 x 10 5 cfu/ g each into the range of 2.54 x 10 5 to 1.58 x 10 3 cfu/ g and 1.18 x 10 5 to 3.08 x 10 3 cfu/ g respectively. In conclusion, the non-thermal irradiation improved the microbial quality of durian whilst maintaining its flavor. (author)

  15. Generation of pure spin currents via spin Seebeck effect in self-biased hexagonal ferrite thin films

    Energy Technology Data Exchange (ETDEWEB)

    Li, Peng; Ellsworth, David; Chang, Houchen; Janantha, Praveen; Richardson, Daniel; Phillips, Preston; Vijayasarathy, Tarah; Wu, Mingzhong, E-mail: mwu@lamar.colostate.edu [Department of Physics, Colorado State University, Fort Collins, Colorado 80523 (United States); Shah, Faisal [Department of Electrical Engineering, University of Notre Dame, Notre Dame, Indiana 46556 (United States)

    2014-12-15

    Light-induced generation of pure spin currents in a Pt(2.5 nm)/BaFe{sub 12}O{sub 19}(1.2 μm)/sapphire(0.5 mm) structure is reported. The BaFe{sub 12}O{sub 19} film had strong in-plane uniaxial anisotropy and was therefore self-biased. Upon exposure to light, a temperature difference (ΔT) was established across the BaFe{sub 12}O{sub 19} thickness that gave rise to a pure spin current in the Pt via the spin Seebeck effect. Via the inverse spin Hall effect, the spin current produced an electric voltage across one of the Pt lateral dimensions. The voltage varied with time in the same manner as ΔT and flipped its sign when the magnetization in BaFe{sub 12}O{sub 19} was reversed.

  16. The Inhibition Effect of Potassium Iodide on the Corrosion of Pure Iron in Sulphuric Acid

    Directory of Open Access Journals (Sweden)

    Tarik Attar

    2014-01-01

    Full Text Available The use of inorganic inhibitors as an alternative to organic compounds is based on the possibility of degradation of organic compounds with time and temperature. The inhibition effect of potassium iodide on the corrosion of pure iron in 0.5 M H2SO4 has been studied by weight loss. It has been observed from the results that the inhibition efficiency (IE% of KI increases from 82.17% to 97.51% with the increase in inhibitor concentration from 1·10−4 to 2·10−3 M. The apparent activation energy (Ea and the equilibrium constant of adsorption (Kads were calculated. The adsorption of the inhibitor on the pure iron surface is in agreement with Langmuir adsorption isotherm.

  17. Size effects of nano-spaced basal stacking faults on the strength and deformation mechanisms of nanocrystalline pure hcp metals

    Science.gov (United States)

    Wang, Wen; Jiang, Ping; Yuan, Fuping; Wu, Xiaolei

    2018-05-01

    The size effects of nano-spaced basal stacking faults (SFs) on the tensile strength and deformation mechanisms of nanocrystalline pure cobalt and magnesium have been investigated by a series of large-scale 2D columnar and 3D molecular dynamics simulations. Unlike the strengthening effect of basal SFs on Mg alloys, the nano-spaced basal SFs are observed to have no strengthening effect on the nanocrystalline pure cobalt and magnesium from MD simulations. These observations could be attributed to the following two reasons: (i) Lots of new basal SFs are formed before (for cobalt) or simultaneously with (for magnesium) the other deformation mechanisms (i.e. the formation of twins and the edge dislocations) during the tensile deformation; (ii) In hcp alloys, the segregation of alloy elements and impurities at typical interfaces, such as SFs, can stablilise them for enhancing the interactions with dislocation and thus elevating the strength. Without such segregation in pure hcp metals, the edge dislocations can cut through the basal SFs although the interactions between the dislocations and the pre-existing SFs/newly formed SFs are observed. The nano-spaced basal SFs are also found to have no restriction effect on the formation of deformation twins.

  18. Distinct configurations of protein complexes and biochemical pathways revealed by epistatic interaction network motifs

    LENUS (Irish Health Repository)

    Casey, Fergal

    2011-08-22

    Abstract Background Gene and protein interactions are commonly represented as networks, with the genes or proteins comprising the nodes and the relationship between them as edges. Motifs, or small local configurations of edges and nodes that arise repeatedly, can be used to simplify the interpretation of networks. Results We examined triplet motifs in a network of quantitative epistatic genetic relationships, and found a non-random distribution of particular motif classes. Individual motif classes were found to be associated with different functional properties, suggestive of an underlying biological significance. These associations were apparent not only for motif classes, but for individual positions within the motifs. As expected, NNN (all negative) motifs were strongly associated with previously reported genetic (i.e. synthetic lethal) interactions, while PPP (all positive) motifs were associated with protein complexes. The two other motif classes (NNP: a positive interaction spanned by two negative interactions, and NPP: a negative spanned by two positives) showed very distinct functional associations, with physical interactions dominating for the former but alternative enrichments, typical of biochemical pathways, dominating for the latter. Conclusion We present a model showing how NNP motifs can be used to recognize supportive relationships between protein complexes, while NPP motifs often identify opposing or regulatory behaviour between a gene and an associated pathway. The ability to use motifs to point toward underlying biological organizational themes is likely to be increasingly important as more extensive epistasis mapping projects in higher organisms begin.

  19. Molecular signature of epistatic selection: interrogating genetic interactions in the sex-ratio meiotic drive of Drosophila simulans.

    Science.gov (United States)

    Chevin, Luis-Miguel; Bastide, Héloïse; Montchamp-Moreau, Catherine; Hospital, Frédéric

    2009-06-01

    Fine scale analyses of signatures of selection allow assessing quantitative aspects of a species' evolutionary genetic history, such as the strength of selection on genes. When several selected loci lie in the same genomic region, their epistatic interactions may also be investigated. Here, we study how the neutral polymorphism pattern was shaped by two close recombining loci that cause 'sex-ratio' meiotic drive in Drosophila simulans, as an example of strong selection with potentially strong epistasis. We compare the polymorphism data observed in a natural population with the results of forward stochastic simulations under several contexts of epistasis between the candidate loci for the drive. We compute the likelihood of different possible scenarios, in order to determine which configuration is most consistent with the data. Our results highlight that fine scale analyses of well-chosen candidate genomic regions provide information-rich data that can be used to investigate the genotype-phenotype-fitness map, which can hardly be studied in genome-wide analyses. We also emphasize that initial conditions and time of observation (here, time after the interruption of a partial selective sweep) are crucial parameters in the interpretation of real data, while these are often overlooked in theoretical studies.

  20. Pure Surface Texture Mapping Technology and it's Application for Mirror Image

    Directory of Open Access Journals (Sweden)

    Wei Feng Wang

    2013-02-01

    Full Text Available Based on the study of pure surface texture mapping technology, pure texture surface rendering method is proposed. The method is combined pure surface texture rendering and view mirror, real-time rendering has an index of refraction, reflection, and the flow of water ripple effect. Through the experimental verification of the validity of the algorithm.

  1. Corrosion of pure OFHC-copper in simulated repository conditions

    International Nuclear Information System (INIS)

    Aaltonen, P.

    1990-04-01

    The research program 'Corrosion of pure OFHC-copper in simulated repository conditions' was planned to provide an experimental evaluation with respect to the theoretical calculations and forecasts made for the corrosion behaviour of pure copper in bentonite groundwater environments at temperatures between 20-80 deg C. The aim of this study in the first place is to evaluate the effects of groundwater composition, bentonite and temperature on the equilibrium and possible corrosion reactions between pure copper and the simulated repository environment. The progress report includes the results obtained after 36 months exposure time

  2. Effect of fractionated extracts and isolated pure compounds of ...

    African Journals Online (AJOL)

    This study attempted to elucidate the neurotransmitter systems involved in the neurophysiological properties of ethanolic extract, fractions and pure isolates of Spondias mombin leaves in mice (n = 6) after intraperitoneal (i.p.) route of administration. The crude ethanolic extract of spondian mombin leaves was fractionated ...

  3. Effects of water chemistry and potential distribution on electrochemical corrosion potential measurements in 553 K pure water

    International Nuclear Information System (INIS)

    Ishida, Kazushige; Wada, Yoichi; Tachibana, Masahiko; Ota, Nobuyuki; Aizawa, Motohiro

    2013-01-01

    The effects of water chemistry distribution on the potential of a reference electrode and of the potential distribution on the measured potential should be known qualitatively to obtain accurate electrochemical corrosion potential (ECP) data in BWRs. First, the effects of oxygen on a platinum reference electrode were studied in 553 K pure water containing dissolved hydrogen (DH) concentration of 26 - 10 5 μg kg -1 (ppb). The platinum electrode worked in the same way as the theoretical hydrogen electrode under the condition that the molar ratio of DH to dissolved oxygen (DO) was more than 10 and that DO was less than 100 ppb. Second, the effects of potential distribution on the measured potential were studied by using the ECP measurement part without platinum deposition on the surfaces connected to another ECP measurement part with platinum deposition on the surfaces in 553 K pure water containing 100 - 130 ppb of DH or 100 - 130 ppb of DH plus 400 ppb of hydrogen peroxide. Measured potentials for each ECP measurement part were in good agreement with literature data for each surface condition. The lead wire connecting point did not affect the measured potential. Potential should be measured at the nearest point from the reference electrode in which case it will be not affected by either the potential distribution or the connection point of the lead wire in pure water. (author)

  4. Ab initio modeling of plasticity in HCP metals: pure zirconium and titanium and effect of oxygen

    International Nuclear Information System (INIS)

    Chaari, Nermine

    2015-01-01

    We performed atomistic simulations to determine screw dislocations properties in pure zirconium and titanium and to explain the hardening effect attributed to oxygen alloying in both hexagonal close-packed transition metals. We used two energetic models: ab initio calculations based on the density functional theory and calculations with an empirical potential. The complete energetic profile of the screw dislocation when gliding in the different slip planes is obtained in pure Zr. Our calculations reveal the existence of a metastable configuration of the screw dislocation partially spread in the first order pyramidal plane. This configuration is responsible for the cross slip of screw dislocations from prismatic planes, the easiest glide planes, to pyramidal or basal planes. This energy profile is affected by oxygen addition. Ab initio calculations reveal two main effects: oxygen enhances pyramidal cross slip by modifying the dislocation core structure, and pins the dislocation in its metastable sessile configuration. The same modeling approach is applied to titanium. In pure Ti, the same configurations of the screw dislocation in Zr are obtained, but with different energy levels. This leads to a different gliding mechanism. The same way as in Zr, oxygen enhances pyramidal glide in Ti by modifying the dislocation core structure. Besides, oxygen atom lowers the energy of the metastable configuration but not enough to pin the dislocation in this sessile configuration. (author) [fr

  5. Effect of couple-stress on the pure bending of a prismatic bar

    International Nuclear Information System (INIS)

    Tzung, F.; Kao, B.; Ho, F.; Tang, P.

    1981-02-01

    An evaluation of the applicability of the couple-stress theory to the stress analysis of graphite structures is performed by solving a pure bending problem. The differences between solutions from the couple-stress theory and from the classical theory of elasticity are compared. It is found that the differences are sufficient to account for the inconsistencies which have often been observed between the classical elasticity theory and actual behavior of graphite under bend and tensile loadings. An experimental procedure to measure the material constants in the couple-stress theory is also suggested. The linear couple-stress theory, the origins of which go back to the turn of the last century, adds linear relations between couple-stresses and rotation gradients to the classical stress-strain law. By adopting the classical assumption that the plane cross section remains plane after deformation, the pure-bending problem is reduced to a plane couple-stress problem with traction-free boundary conditions. A general solution for an isotropic elastic prismatic bar under pure bending is then obtained using the Airy stress function and another stress function wich accounts for the couple-stresss. For a cylindrical bar, it reduces to a simple series solution. The moment-curvature and stress-curvature relations derived for a cylindrical bar from the general solution are used to examine the effect of couple-stresses. Numerical compilation of relations indicates that the couple stress parameters can be practically determined by measuring the moment-curvature ratio of various diametered specimens under bending. Although there is not sufficient data for such evaluation at present, it appears that the theory is consistent with the limited bend and tensile strength data of cylindrical specimens for H-451 graphite

  6. Scattering of massive open strings in pure spinor

    International Nuclear Information System (INIS)

    Park, I.Y.

    2011-01-01

    In Park (2008) , it was proposed that the D-brane geometry could be produced by open string quantum effects. In an effort to verify the proposal, we consider scattering amplitudes involving massive open superstrings. The main goal of this paper is to set the ground for two-loop 'renormalization' of an oriented open superstring on a D-brane and to strengthen our skill in the pure spinor formulation of a superstring, an effective tool for multi-loop string diagrams. We start by reviewing scattering amplitudes of massless states in the 2D component method of the NSR formulation. A few examples of massive string scattering are worked out. The NSR results are then reproduced in the pure spinor formulation. We compute the amplitudes using the unintegrated form of the massive vertex operator constructed by Berkovits and Chandia (2002) . We point out that it may be possible to discover new Riemann type identities involving Jacobi θ-functions by comparing a NSR computation and the corresponding pure spinor computation.

  7. Mixtures of maximally entangled pure states

    Energy Technology Data Exchange (ETDEWEB)

    Flores, M.M., E-mail: mflores@nip.up.edu.ph; Galapon, E.A., E-mail: eric.galapon@gmail.com

    2016-09-15

    We study the conditions when mixtures of maximally entangled pure states remain entangled. We found that the resulting mixed state remains entangled when the number of entangled pure states to be mixed is less than or equal to the dimension of the pure states. For the latter case of mixing a number of pure states equal to their dimension, we found that the mixed state is entangled provided that the entangled pure states to be mixed are not equally weighted. We also found that one can restrict the set of pure states that one can mix from in order to ensure that the resulting mixed state is genuinely entangled. Also, we demonstrate how these results could be applied as a way to detect entanglement in mixtures of the entangled pure states with noise.

  8. The effect of ultrasound on particle size, color, viscosity and polyphenol oxidase activity of diluted avocado puree.

    Science.gov (United States)

    Bi, Xiufang; Hemar, Yacine; Balaban, Murat O; Liao, Xiaojun

    2015-11-01

    The effect of ultrasound treatment on particle size, color, viscosity, polyphenol oxidase (PPO) activity and microstructure in diluted avocado puree was investigated. The treatments were carried out at 20 kHz (375 W/cm(2)) for 0-10 min. The surface mean diameter (D[3,2]) was reduced to 13.44 μm from an original value of 52.31 μm by ultrasound after 1 min. A higher L(∗) value, ΔE value and lower a(∗) value was observed in ultrasound treated samples. The avocado puree dilution followed pseudoplastic flow behavior, and the viscosity of diluted avocado puree (at 100 s(-1)) after ultrasound treatment for 1 min was 6.0 and 74.4 times higher than the control samples for dilution levels of 1:2 and 1:9, respectively. PPO activity greatly increased under all treatment conditions. A maximum increase of 25.1%, 36.9% and 187.8% in PPO activity was found in samples with dilution ratios of 1:2, 1:5 and 1:9, respectively. The increase in viscosity and measured PPO activity might be related to the decrease in particle size. The microscopy images further confirmed that ultrasound treatment induced disruption of avocado puree structure. Copyright © 2015 Elsevier B.V. All rights reserved.

  9. Entropy balance in pure interactions of open quantum systems

    International Nuclear Information System (INIS)

    Urigu, R.

    1989-01-01

    Processes are considered in which a statistical ensemble w of quantum systems is split into ensembles, or channels (w i ), conditional to the occurrence, with respective probabilities (p i w ), of associated macroscopic effects. These processes are described here by a family of operations T i : w → p i w w iT , which remarkably generalize the usual state reductions of the nondestructive measurements. In a previous work it was proved that the microscopic entropy of the given open system decreases or at most remains constant if all the T i are pure operations, i.e., they transform pure states into pure states; it is proved here that the increase in entropy of the external world, computed as S Tm (w) = - Σ i p i w lg p i w , is sufficient to compensate for such an entropy decrease whenever the T i are all pure operations of the first kind, whereas whenever some T i is pure of the second kind (or nonpure, too), the total entropy, computed as above, may decrease

  10. Corrosion of pure magnesium under thin electrolyte layers

    International Nuclear Information System (INIS)

    Zhang Tao; Chen Chongmu; Shao Yawei; Meng Guozhe; Wang Fuhui; Li Xiaogang; Dong Chaofang

    2008-01-01

    The corrosion behavior of pure magnesium was investigated by means of cathodic polarization curve, electrochemical impedance spectroscopy (EIS) and electrochemical noise (EN) under aerated and deaerated thin electrolyte layers (TEL) with various thicknesses. Based on shot noise theory and stochastic theory, the EN results were quantitatively analyzed by using the Weibull and Gumbel distribution function, respectively. The results show that the cathodic process of pure magnesium under thin electrolyte layer was dominated by hydrogen reduction. With the decreasing of thin electrolyte layer thickness, cathodic process was retarded slightly while the anodic process was inhibited significantly, which indicated that both the cathodic and anodic process were inhibited in the presence of oxygen. The absence of oxygen decreased the corrosion resistance of pure magnesium in case of thin electrolyte layer. The corrosion was more localized under thin electrolyte layer than that in bulk solution. The results also demonstrate that there exist two kinds of effects for thin electrolyte layer on the corrosion behavior of pure magnesium: (1) the rate of pit initiation was evidently retarded compared to that in bulk solution; (2) the probability of pit growth oppositely increased. The corrosion model of pure magnesium under thin electrolyte layer was suggested in the paper

  11. Effect of high hydrostatic pressure processing on the background microbial loads and quality of cantaloupe puree

    Science.gov (United States)

    The objective of this study was to investigate and evaluate the effects of high hydrostatic pressure (HHP) applied to cantaloupe puree (CP) on microbial loads and product quality during storage for 10 days at 4 degrees C. Freshly prepared, double sealed and double bagged CP (ca. 5 g) was pressure tr...

  12. Effect of web openings on the structural behavior of RC beams subjected to pure torsion

    Directory of Open Access Journals (Sweden)

    Abdo Taha

    2017-01-01

    Full Text Available In the construction of modern buildings, the presence of openings became a necessity nowadays in order to accommodate the many pipes and ducts required for the different services. On the other hand, the presence of these openings in RC beams affects their structural behavior. One important behavior that needs further study would be torsion. Currently, there are no guide lines available to analyze or design RC beams with web openings under pure torsion. Thus, the main objective of this research is to investigate the behavior of simply supported RC beams with openings subjected to pure torsion. In the first part of this paper, an experimental study is conducted on seven beams subjected to pure torsion loading in order to investigate the effect of the number of openings, the spacing between stirrups, and beam depth. All beams have a constant clear span length of 1800 mm and a constant beam width of 150 mm. The beams have varying opening number and stirrups arrangement as well as varying beam depth in order to investigate the effect of these parameters on the behavior of the beams. Systematic measurements such as the cracking torque, the ultimate torque, the angle of rotation of the beam at cracking, and the angle of rotation of the beam at the ultimate load are conducted for further understanding of the beam behavior under torsion. In the second part of the paper, the experimental results are compared with the numerical results obtained using the non-linear finite element analysis program, ANSYS. Good agreement between the experimental and numerical results is found.

  13. Endoscopic Endonasal Surgery for Purely Intrathird Ventricle Craniopharyngioma.

    Science.gov (United States)

    Nishioka, Hiroshi; Fukuhara, Noriaki; Yamaguchi-Okada, Mitsuo; Yamada, Shozo

    2016-07-01

    Extended endoscopic transsphenoidal surgery (EETS) is a safe and effective treatment for many suprasellar craniopharyngiomas, including those with third-ventricle involvement. Craniopharyngioma entirely within the third ventricle (purely intraventricular type), however, is generally regarded unsuitable for treatment with EETS. Three patients underwent total removal of a purely intraventricular craniopharyngioma with inferior extension via EETS by direct incision of the bulging, stretched ventricular floor and fine dissection from the ventricular wall. In 2 patients with an anteriorly displaced chiasm, the space between the chiasm and pituitary stalk created a wide corridor to the ventricle, whereas in the third case, in which the infrachiasmal space was somewhat narrowed, partial sacrifice of the pituitary gland was necessary to obtain sufficient space. Despite preservation of the stalk in 2 patients, hypopituitarism and diabetes insipidus developed after surgery. There was no other complication including obesity. Selected patients with purely intraventricular craniopharyngioma can be treated effectively and safely with EETS. Those with inferior extension in the interpeduncular fossa and anterior displacement of the chiasm may be suitable candidates. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. Spatiotemporal dynamics and epistatic interaction sites in dengue virus type 1: a comprehensive sequence-based analysis.

    Directory of Open Access Journals (Sweden)

    Pei-Yu Chu

    Full Text Available The continuing threat of dengue fever necessitates a comprehensive characterisation of its epidemiological trends. Phylogenetic and recombination events were reconstructed based on 100 worldwide dengue virus (DENV type 1 genome sequences with an outgroup (prototypes of DENV2-4. The phylodynamic characteristics and site-specific variation were then analysed using data without the outgroup. Five genotypes (GI-GV and a ladder-like structure with short terminal branch topology were observed in this study. Apparently, the transmission of DENV1 was geographically random before gradual localising with human activity as GI-GIII in South Asia, GIV in the South Pacific, and GV in the Americas. Genotypes IV and V have recently shown higher population densities compared to older genotypes. All codon regions and all tree branches were skewed toward a negative selection, which indicated that their variation was restricted by protein function. Notably, multi-epistatic interaction sites were found in both PrM 221 and NS3 1730. Recombination events accumulated in regions E, NS3-NS4A, and particularly in region NS5. The estimated coevolution pattern also highlights the need for further study of the biological role of protein PrM 221 and NS3 1730. The recent transmission of emergent GV sublineages into Central America and Europe mandates closely monitoring of genotype interaction and succession.

  15. Combined Effects of Irrigation Regime, Genotype, and Harvest Stage Determine Tomato Fruit Quality and Aptitude for Processing into Puree.

    Science.gov (United States)

    Arbex de Castro Vilas Boas, Alexandre; Page, David; Giovinazzo, Robert; Bertin, Nadia; Fanciullino, Anne-Laure

    2017-01-01

    Industry tomatoes are produced under a range of climatic conditions and practices which significantly impact on main quality traits of harvested fruits. However, the quality of tomato intended for processing is currently addressed on delivery through color and Brix only, whereas other traits are overlooked. Very few works provided an integrated view of the management of tomato puree quality throughout the chain. To gain insights into pre- and post-harvest interactions, four genotypes, two water regimes, three maturity stages, and two processes were investigated. Field and glasshouse experiments were conducted near Avignon, France, from May to August 2016. Two irrigation regimes were applied: control plants were irrigated in order to match 100% of evapotranspiration (ETP); water deficit (WD) plants were irrigated as control plants until anthesis of the first flowers, then irrigation was reduced to 60 and 50% ETP in field, and glasshouse respectively. Fruits were collected at three stages during ripening. Their color, fresh weight, dry matter content, and metabolite contents were determined before processing. Pericarp cell size was evaluated in glasshouse only. Two laboratory-scaled processing methods were applied before structural and biochemical analyses of the purees. Results outlined interactive effects between crop and process management. WD hardly reduced yield, but increased dry matter content in the field, in contrast to the glasshouse. The puree viscosity strongly depended on the genotype and the maturity stage, but it was disconnected from fruit dry matter content or Brix. The process impact on puree viscosity strongly depended on water supply during fruit production. Moreover, the lycopene content of fresh fruit may influence puree viscosity. This work opens new perspectives for managing puree quality in the field showing that it was possible to reduce water supply without affecting yield and to improve puree quality.

  16. Combined Effects of Irrigation Regime, Genotype, and Harvest Stage Determine Tomato Fruit Quality and Aptitude for Processing into Puree

    Directory of Open Access Journals (Sweden)

    Alexandre Arbex de Castro Vilas Boas

    2017-10-01

    Full Text Available Industry tomatoes are produced under a range of climatic conditions and practices which significantly impact on main quality traits of harvested fruits. However, the quality of tomato intended for processing is currently addressed on delivery through color and Brix only, whereas other traits are overlooked. Very few works provided an integrated view of the management of tomato puree quality throughout the chain. To gain insights into pre- and post-harvest interactions, four genotypes, two water regimes, three maturity stages, and two processes were investigated. Field and glasshouse experiments were conducted near Avignon, France, from May to August 2016. Two irrigation regimes were applied: control plants were irrigated in order to match 100% of evapotranspiration (ETP; water deficit (WD plants were irrigated as control plants until anthesis of the first flowers, then irrigation was reduced to 60 and 50% ETP in field, and glasshouse respectively. Fruits were collected at three stages during ripening. Their color, fresh weight, dry matter content, and metabolite contents were determined before processing. Pericarp cell size was evaluated in glasshouse only. Two laboratory-scaled processing methods were applied before structural and biochemical analyses of the purees. Results outlined interactive effects between crop and process management. WD hardly reduced yield, but increased dry matter content in the field, in contrast to the glasshouse. The puree viscosity strongly depended on the genotype and the maturity stage, but it was disconnected from fruit dry matter content or Brix. The process impact on puree viscosity strongly depended on water supply during fruit production. Moreover, the lycopene content of fresh fruit may influence puree viscosity. This work opens new perspectives for managing puree quality in the field showing that it was possible to reduce water supply without affecting yield and to improve puree quality.

  17. Combined Effects of Irrigation Regime, Genotype, and Harvest Stage Determine Tomato Fruit Quality and Aptitude for Processing into Puree

    Science.gov (United States)

    Arbex de Castro Vilas Boas, Alexandre; Page, David; Giovinazzo, Robert; Bertin, Nadia; Fanciullino, Anne-Laure

    2017-01-01

    Industry tomatoes are produced under a range of climatic conditions and practices which significantly impact on main quality traits of harvested fruits. However, the quality of tomato intended for processing is currently addressed on delivery through color and Brix only, whereas other traits are overlooked. Very few works provided an integrated view of the management of tomato puree quality throughout the chain. To gain insights into pre- and post-harvest interactions, four genotypes, two water regimes, three maturity stages, and two processes were investigated. Field and glasshouse experiments were conducted near Avignon, France, from May to August 2016. Two irrigation regimes were applied: control plants were irrigated in order to match 100% of evapotranspiration (ETP); water deficit (WD) plants were irrigated as control plants until anthesis of the first flowers, then irrigation was reduced to 60 and 50% ETP in field, and glasshouse respectively. Fruits were collected at three stages during ripening. Their color, fresh weight, dry matter content, and metabolite contents were determined before processing. Pericarp cell size was evaluated in glasshouse only. Two laboratory-scaled processing methods were applied before structural and biochemical analyses of the purees. Results outlined interactive effects between crop and process management. WD hardly reduced yield, but increased dry matter content in the field, in contrast to the glasshouse. The puree viscosity strongly depended on the genotype and the maturity stage, but it was disconnected from fruit dry matter content or Brix. The process impact on puree viscosity strongly depended on water supply during fruit production. Moreover, the lycopene content of fresh fruit may influence puree viscosity. This work opens new perspectives for managing puree quality in the field showing that it was possible to reduce water supply without affecting yield and to improve puree quality. PMID:29051767

  18. Proton irradiation effects on optical attenuation in doped- and pure-silica fibers

    International Nuclear Information System (INIS)

    Sakasai, Kaoru; Bueker, H.; Haesing, F.W.; Pfeiffer, F.

    1999-05-01

    Optical attenuation in doped- and pure-silica fibers was measured at wavelengths of 470 nm, 660 nm, and 850 nm during and after 20 MeV proton irradiation. In the experiment the fibers were arranged on a holder to make one layer' so that uniform proton irradiation can be achieved to them. The induced loss of the doped-silica fiber increased strongly at the beginning of the first irradiation, and decreased slowly after stopping of the beam. In the second irradiation, however, the developed loss was not so large. On the other hand, the loss of the pure-silica fiber increased gradually in the first irradiation, and decreased very quickly after the beam stopped. The loss increased stepwise at the very beginning of the second irradiation. Small luminescence from the fibers during irradiation was observed also. The luminescence of the pure-silica fiber was slightly larger than that of the doped-silica fiber. The induced loss of HCP fibers was also measured when a SiO 2 plate was set in front of the fibers. It may be possible to estimate the proton dose in materials using fiber-optic technique. Proton sensitivities of doped- and pure-silica fibers were, respectively, 1.0 x 10 -10 at 660 nm and 5.5 x 10 -12 at 470 nm in units of (dB/m)/(protons/cm 2 ), where the values were estimated from the slope of the loss growth curves at the beginning of the first irradiation. (author)

  19. Perspectives on the Pure-Tone Audiogram.

    Science.gov (United States)

    Musiek, Frank E; Shinn, Jennifer; Chermak, Gail D; Bamiou, Doris-Eva

    The pure-tone audiogram, though fundamental to audiology, presents limitations, especially in the case of central auditory involvement. Advances in auditory neuroscience underscore the considerably larger role of the central auditory nervous system (CANS) in hearing and related disorders. Given the availability of behavioral audiological tests and electrophysiological procedures that can provide better insights as to the function of the various components of the auditory system, this perspective piece reviews the limitations of the pure-tone audiogram and notes some of the advantages of other tests and procedures used in tandem with the pure-tone threshold measurement. To review and synthesize the literature regarding the utility and limitations of the pure-tone audiogram in determining dysfunction of peripheral sensory and neural systems, as well as the CANS, and to identify other tests and procedures that can supplement pure-tone thresholds and provide enhanced diagnostic insight, especially regarding problems of the central auditory system. A systematic review and synthesis of the literature. The authors independently searched and reviewed literature (journal articles, book chapters) pertaining to the limitations of the pure-tone audiogram. The pure-tone audiogram provides information as to hearing sensitivity across a selected frequency range. Normal or near-normal pure-tone thresholds sometimes are observed despite cochlear damage. There are a surprising number of patients with acoustic neuromas who have essentially normal pure-tone thresholds. In cases of central deafness, depressed pure-tone thresholds may not accurately reflect the status of the peripheral auditory system. Listening difficulties are seen in the presence of normal pure-tone thresholds. Suprathreshold procedures and a variety of other tests can provide information regarding other and often more central functions of the auditory system. The audiogram is a primary tool for determining type

  20. In vitro corrosion, cytotoxicity and hemocompatibility of bulk nanocrystalline pure iron

    International Nuclear Information System (INIS)

    Nie, F L; Zheng, Y F; Wei, S C; Hu, C; Yang, G

    2010-01-01

    Bulk nanocrystalline pure iron rods were fabricated by the equal channel angular pressure (ECAP) technique up to eight passes. The microstructure and grain size distribution, natural immersion and electrochemical corrosion in simulated body fluid, cellular responses and hemocompatibility were investigated in this study. The results indicate that nanocrystalline pure iron after severe plastic deformation (SPD) would sustain durable span duration and exhibit much stronger corrosion resistance than that of the microcrystalline pure iron. The interaction of different cell lines reveals that the nanocrystalline pure iron stimulates better proliferation of fibroblast cells and preferable promotion of endothelialization, while inhibits effectively the viability of vascular smooth muscle cells (VSMCs). The burst of red cells and adhesion of the platelets were also substantially suppressed on contact with the nanocrystalline pure iron in blood circulation. A clear size-dependent behavior from the grain nature deduced by the gradual refinement microstructures was given and well-behaved in vitro biocompatibility of nanocrystalline pure iron was concluded.

  1. Generalized pure Lovelock gravity

    Science.gov (United States)

    Concha, Patrick; Rodríguez, Evelyn

    2017-11-01

    We present a generalization of the n-dimensional (pure) Lovelock Gravity theory based on an enlarged Lorentz symmetry. In particular, we propose an alternative way to introduce a cosmological term. Interestingly, we show that the usual pure Lovelock gravity is recovered in a matter-free configuration. The five and six-dimensional cases are explicitly studied.

  2. Effect of calcination temperature on the structural, optical and magnetic properties of pure and Fe-doped ZnO nanoparticles

    Directory of Open Access Journals (Sweden)

    Pal Singh Raminder Preet

    2016-06-01

    Full Text Available In the present study, pure ZnO and Fe-doped ZnO (Zn0.97Fe0.03O nanoparticles were synthesized by simple coprecipitation method with zinc acetate, ferric nitrate and sodium hydroxide precursors. Pure ZnO and Fe-doped ZnO were further calcined at 450 °C, 600 °C and 750 °C for 2 h. The structural, morphological and optical properties of the samples were characterized by X-ray diffractometer (XRD, scanning electron microscope (SEM, energy dispersive spectroscopy (EDS and UV-Vis absorption spectroscopy. The X-ray diffraction studies revealed that the as-synthesized pure and doped ZnO nanoparticles have hexagonal wurtzite structure. The average crystallite size was calculated using Debye-Scherrer’s formula. The particle size was found to be in nano range and increased with an increase in calcination temperature. SEM micrographs confirmed the formation of spherical nanoparticles. Elemental compositions of various elements in pure and doped ZnO nanoparticles were determined by EDX spectroscopy. UV-Vis absorption spectra showed red shift (decrease in band gap with increasing calcination temperature. Effect of calcination on the magnetic properties of Fe-doped ZnO sample was also studied using vibrating sample magnetometer (VSM. M-H curves at room temperature revealed that coercivity and remanent polarization increase with an increase in calcination temperature from 450 °C to 750 °C, whereas reverse effect was observed for magnetization saturation.

  3. Case study into the effect of intensive mass training on chronic pure alexia

    DEFF Research Database (Denmark)

    Wilms, Inge Linda

    2015-01-01

    This paper describes the results from a case study into the effects of intensive reading training on a patient with acquired pure alexia disorder. The training targeted the various stages of the basic reading process based on the theories of the psycholinguistic language model as a mixture......, the training was conducted over a short but intensive period of time and thirdly, the training was focused on regaining reading abilities without the use of compensatory techniques by targeting the various areas of the reading process according to the psycholinguistic model. The study demonstrated...

  4. Micromechanical properties of single crystals and polycrystals of pure α-titanium: anisotropy of microhardness, size effect, effect of the temperature (77-300 K)

    Science.gov (United States)

    Lubenets, S. V.; Rusakova, A. V.; Fomenko, L. S.; Moskalenko, V. A.

    2018-01-01

    The anisotropy of microhardness of pure α-Ti single crystals, indentation size effect in single-crystal, course grained (CG) pure and nanocrystalline (NC) VT1-0 titanium, as well as the temperature dependences of the microhardness of single-crystal and CG Ti in the temperature range 77-300 K were studied. The minimum value of hardness was obtained when indenting into the basal plane (0001). The indentation size effect (ISE) was clearly observed in the indentation of soft high-purity single-crystal iodide titanium while it was the least pronounced in a sample of nanocrystalline VT1-0 titanium. It has been demonstrated that the ISE can be described within the model of geometrically necessary dislocations (GND), which follows from the theory of strain gradient plasticity. The true hardness and others parameters of the GND model were determined for all materials. The temperature dependence of the microhardness is in agreement with the idea of the governing role of Peierls relief in the dislocation thermally-activated plastic deformation of pure titanium as has been earlier established and justified in macroscopic tensile investigations at low temperatures. The activation energy and activation volume of dislocation motion in the strained region under the indenter were estimated.

  5. Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1

    Energy Technology Data Exchange (ETDEWEB)

    Jenson, Justin M.; Ryan, Jeremy A.; Grant, Robert A.; Letai, Anthony; Keating, Amy E. (DFCI); (MIT)

    2017-06-08

    Overexpression of anti-apoptotic Bcl-2 family proteins contributes to cancer progression and confers resistance to chemotherapy. Small molecules that target Bcl-2 are used in the clinic to treat leukemia, but tight and selective inhibitors are not available for Bcl-2 paralog Bfl-1. Guided by computational analysis, we designed variants of the native BH3 motif PUMA that are > 150-fold selective for Bfl-1 binding. The designed peptides potently trigger disruption of the mitochondrial outer membrane in cells dependent on Bfl-1, but not in cells dependent on other anti-apoptotic homologs. High-resolution crystal structures show that designed peptide FS2 binds Bfl-1 in a shifted geometry, relative to PUMA and other binding partners, due to a set of epistatic mutations. FS2 modified with an electrophile reacts with a cysteine near the peptide-binding groove to augment specificity. Designed Bfl-1 binders provide reagents for cellular profiling and leads for developing enhanced and cell-permeable peptide or small-molecule inhibitors.

  6. Generalized pure Lovelock gravity

    Directory of Open Access Journals (Sweden)

    Patrick Concha

    2017-11-01

    Full Text Available We present a generalization of the n-dimensional (pure Lovelock Gravity theory based on an enlarged Lorentz symmetry. In particular, we propose an alternative way to introduce a cosmological term. Interestingly, we show that the usual pure Lovelock gravity is recovered in a matter-free configuration. The five and six-dimensional cases are explicitly studied.

  7. Effect of high hydrostatic pressure processing on the background microbial loads and quality of cantaloupe puree.

    Science.gov (United States)

    Mukhopadhyay, Sudarsan; Sokorai, Kimberly; Ukuku, Dike; Fan, Xuetong; Juneja, Vijay

    2017-01-01

    The objective of this study was to investigate and evaluate the effects of high hydrostatic pressure (HHP) applied to cantaloupe puree (CP) on microbial loads and product quality during storage for 10days at 4°C. Freshly prepared, double sealed and double bagged CP (ca. 5g) was pressure treated at 300, 400 and 500MPa at 8°C and 15°C for 5min. Microflora populations, soluble solid content, pH, color, antioxidant activity, appearance and aroma were measured at 1, 6, and 10d of storage. Results showed that high pressure treatment of 300MPa (8°C and 15°C) resulted in reduction of total aerobic plate count from 3.3 to 1.8logCFU/g. The treatment reduced the populations of native aerobic plate count to non-detectable levels (detection limit 1logCFU/g) at 400MPa and 500MPa pressures at 15°C. Pressure treatment completely inactivated mold and yeast in puree below the limits of detection at day 1 and no regrowth was observed during 10days of storage at 4°C while mold and yeast in untreated puree survived during the storage. High pressure treatment did not show any adverse impact on physical properties as soluble solid content (SSC, 11.2°Brix) and acidity (pH, 6.9). The instrumental color parameters (L*, a*, b*) were affected due to HHP treatment creating a slightly lighter product, compared to control, as indicated by higher L.* and lower a* values. However the change was not detected by the sensory panel while evaluating appearance scores. Pressure treatment did not affect the antioxidant capacity of puree product compared to control. Visual appearance and sniffing aroma test by panel revealed no adverse changes in the sensory parameters as a result of HHP treatment. HHP method described in this study appears to be a promising way to inactivate spoilage microorganisms in the cantaloupe puree and maintain quality. This study provides a viable option for preservation and marketing this product. Published by Elsevier Ltd.

  8. In vitro degradation kinetics of pure PLA and Mg/PLA composite: Effects of immersion temperature and compression stress.

    Science.gov (United States)

    Li, Xuan; Chu, Chenglin; Wei, Yalin; Qi, Chenxi; Bai, Jing; Guo, Chao; Xue, Feng; Lin, Pinghua; Chu, Paul K

    2017-01-15

    The effects of the immersion temperature and compression stress on the in vitro degradation behavior of pure poly-lactic acid (pure-PLA) and PLA-based composite unidirectionally reinforced with micro-arc oxidized magnesium alloy wires (Mg/PLA or MAO-MAWs/PLA) are investigated. The degradation kinetics of pure-PLA and the PLA matrix in MAO-MAWs/PLA exhibit an Arrhenius-type behavior. For the composite, the synergic degradation of MAO-MAWs maintains a steady pH and mitigates the degradation of PLA matrix during immersion. However, the external compression stress decreases the activation energy (E a ) and pre-exponential factor (k 0 ) consequently increasing the degradation rate of PLA. Under a compression stress of 1MPa, E a and k 0 of pure PLA are 57.54kJ/mol and 9.74×10 7 day -1 , respectively, but 65.5kJ/mol and 9.81×10 8 day -1 for the PLA matrix in the composite. Accelerated tests are conducted in rising immersion temperature in order to shorten the experimental time. Our analysis indicates there are well-defined relationships between the bending strength of the specimens and the PLA molecular weight during immersion, which are independent of the degradation temperature and external compression stress. Finally, a numerical model is established to elucidate the relationship of bending strength, the PLA molecular weight, activation energy, immersion time and temperature. We systematically evaluate the effects of compression stress and temperature on the degradation properties of two materials: (pure-PLA) and MAO-MAWs/PLA (or Mg/PLA). The initial in vitro degradation kinetics of the unstressed or stressed pure-PLA and MAO-MAWs/PLA composite is confirmed to be Arrhenius-like. MAO-MAWs and external compression stress would influence the degradation activation energy (E a ) and pre-exponential factor (k 0 ) of PLA, and we noticed there is a linear relationship between E a and ln k 0 . Thereafter, we noticed that Mg 2+ , not H + , plays a significant role on the

  9. Square-root measurement for pure states

    International Nuclear Information System (INIS)

    Huang Siendong

    2005-01-01

    Square-root measurement is a very useful suboptimal measurement in many applications. It was shown that the square-root measurement minimizes the squared error for pure states. In this paper, the least squared error problem is reformulated and a new proof is provided. It is found that the least squared error depends only on the average density operator of the input states. The properties of the least squared error are then discussed, and it is shown that if the input pure states are uniformly distributed, the average probability of error has an upper bound depending on the least squared error, the rank of the average density operator, and the number of the input states. The aforementioned properties help explain why the square-root measurement can be effective in decoding processes

  10. Critical current of pure SNS junctions

    International Nuclear Information System (INIS)

    Golub, A.A.; Bezzub, O.P.

    1982-01-01

    Boundary conditions at the superconductor-normal metal interface are determined, taking into account the differences in the effective masses and the density of states of the metals constituting the transition and assumed to be pure. The potential barrier of the interface is chosen to be zero. The critical current of the junction is calculated [ru

  11. The osteoinductive effect of chitosan-collagen composites around pure titanium implant surfaces in rats.

    Science.gov (United States)

    Kung, S; Devlin, H; Fu, E; Ho, K-Y; Liang, S-Y; Hsieh, Y-D

    2011-02-01

    The enhancing effects of chitosan on activation of platelets and differentiation of osteoprogenitor cells have been demonstrated in vitro. The purpose of this study was to evaluate the in vivo osteoinductive effect of chitosan-collagen composites around pure titanium implant surfaces. Chitosan-collagen composites containing chitosan of different molecular weights (450 and 750 kDa) were wrapped onto titanium implants and embedded into the subcutaneous area on the back of 15 Sprague-Dawley rats. The control consisted of implants wrapped with plain collagen type I membranes. Implants and surrounding tissues were retrieved 6 wks after surgery and identified by Alizarin red and Alcian blue whole mount staining. The newly formed structures in the test groups were further analyzed by Toluidine blue and Masson-Goldner trichrome staining, and immunohistochemical staining with osteopontin and alkaline phosphotase. The bone formation parameters of the new bone in the two test groups were measured and compared. New bone formed ectopically in both chitosan-collagen groups, whereas no bone induction occurred in the negative control group. These newly formed bone-like structures were further confirmed by immunohistochemical staining. Comparison of bone parameters of the newly induced bone revealed no statistically significant differences between the 450 and 750 kDa chitosan-collagen groups. Our results demonstrated that chitosan-collagen composites might induce in vivo new bone formation around pure titanium implant surfaces. Different molecular weights of chitosan did not show significantly different effects on the osteoinductive potential of the test materials. © 2010 John Wiley & Sons A/S.

  12. Compound effects of inhaling pure oxygen and lifting height on ear baric function in a hypobaric chamber

    Directory of Open Access Journals (Sweden)

    Dong-qing WEN

    2017-02-01

    Full Text Available Objective To compare the ear baric function between 4000m altitude chamber test with inhaling air and 6900m altitude chamber test with inhaling pure oxygen. Methods Eleven healthy male volunteers attended two tests as two groups by self-comparison. As the air group the volunteers inhaled air at 4000m, while as the pure oxygen group they inhaled pure oxygen at 6900m altitude, and the time interval between the two tests was more than two weeks. During the test, the volunteers breathed air or pure oxygen at random for 1h, and then were exposed at a speed of 20m/s to the target altitude for 5min. Hereafter they were sent back to the ground at the same speed. The changes of subjective symptoms, degree of tympanic congestion, acoustic immitance index and pure-tone auditory threshold were recorded before and after the test. The acoustic impedance index and pure-tone threshold were statistically analyzed. Results Four volunteers (4 ears in air group and 7 volunteers (7 ears in pure oxygen group reported ear pain in altitude chamber exposures, respectively. The pain-triggering altitude was higher in the pure oxygen group. Immediately after tests, there were 3 (3 ears and 5 volunteers (5 ears with Ⅲ degree congestion of the tympanic membrane in the two groups respectively. Four volunteers (6 ears developed gradually aggravated hemorrhages after altitude exposure. And the tympanic membrane congestion difference between groups was statistically significant at 3 and 24h after tests (P<0.01. The type A tympanogram appeared in 11 (15 ears and 11 (14 ears volunteers respectively immediately after tests. The increase of static compliance value was significantly greater in pure oxygen group than in air group immediately after tests (P<0.05, the decrease of middle ear pressure was more significant in pure oxygen group than in air group at 3 and 24h after tests (P<0.05. Both the two altitude exposure tests resulted in eustachian tube dysfunction. At 3 and

  13. Thermodynamics on the micellization of various pure and mixed surfactants: Effects of head- and tail-groups

    International Nuclear Information System (INIS)

    Lee, Nam-Min; Lee, Byung-Hwan

    2016-01-01

    Highlights: • The values of critical micelle concentration of various pure and mixed surfactants are measured. • Thermodynamic parameters’ values are calculated to analyze the effects of head- and tail-groups on the micellization. • All the thermodynamic parameters’ values are decreasing with the increase of temperature. • The thermodynamic parameters’ values are depending severely on the chain length of alkyl group. - Abstract: The values of critical micelle concentration (CMC) for the micellization of various pure and mixed surfactants are determined by the UV–Vis spectrophotometric method. And the effects of temperature on the CMC values have been measured and thermodynamic parameters’ values are calculated to analyse the effects of head- and tail-groups on the micellization of surfactant molecules. The results show that the values of ΔG"o are negative and those of ΔS"o are positive for the micellization of all the surfactants within the measured temperature range. But the values of ΔH"o are positive or negative, depending on the kinds of surfactants. All these thermodynamic parameters’ values are decreasing together with the increase of temperature for all the surfactants. And these thermodynamic parameters’ values are depending severely on the chain length of alkyl group also as much as on the head-groups of surfactant molecules.

  14. Laser-induced generation of pure tensile stresses

    International Nuclear Information System (INIS)

    Niemz, M.H.; Lin, C.P.; Pitsillides, C.; Cui, J.; Doukas, A.G.; Deutsch, T.F.

    1997-01-01

    While short compressive stresses can readily be produced by laser ablation, the generation of pure tensile stresses is more difficult. We demonstrate that a 90 degree prism made of polyethylene can serve to produce short and pure tensile stresses. A compressive wave is generated by ablating a thin layer of strongly absorbing ink on one surface of the prism with a Q-switched frequency-doubled Nd:YAG laser. The compressive wave driven into the prism is reflected as a tensile wave by the polyethylene-air interface at its long surface. The low acoustic impedance of polyethylene makes it ideal for coupling tensile stresses into liquids. In water, tensile stresses up to -200bars with a rise time of the order of 20 ns and a duration of 100 ns are achieved. The tensile strength of water is determined for pure tensile stresses lasting for 100 ns only. The technique has potential application in studying the initiation of cavitation in liquids and in comparing the effect of compressive and tensile stress transients on biological media. copyright 1997 American Institute of Physics

  15. Pure homology of algebraic varieties

    OpenAIRE

    Weber, Andrzej

    2003-01-01

    We show that for a complete complex algebraic variety the pure component of homology coincides with the image of intersection homology. Therefore pure homology is topologically invariant. To obtain slightly more general results we introduce "image homology" for noncomplete varieties.

  16. Effect of fractionated extracts and isolated pure compounds of Spondias mombin (L. Anacardiaceae) leaves on novelty-induced rearing and grooming behaviours in mice.

    Science.gov (United States)

    Ayoka, Abiodun O; Owolabi, Rotimi A; Bamitale, Samuel K; Akomolafe, Rufus O; Aladesanmi, Joseph A; Ukponmwan, Eghe O

    2013-01-01

    This study attempted to elucidate the neurotransmitter systems involved in the neurophysiological properties of ethanolic extract, fractions and pure isolates of Spondias mombin leaves in mice (n = 6) after intraperitoneal (i.p.) route of administration.The crude ethanolic extract of Spondian mombin leaves was fractionated using the partitioning method to obtain the ethylacetate, butanolic and aqueous fractions. Open column chromatographic fractionation of the ethylacetate fraction yielded seven sub-fractions, out of which the pure coumaroyl, quercetin and gallic acid derivatives were obtained after purification on Sephadex LH 20. The ethanolic extract, butanolic fraction, ethylacetate subfractions and pure isolates of the Spondian mombin leaves were tested on novelty-induced rearing and grooming behaviours in mice with standard pharmacological tools using the open field method. The extract and its fractions decreased novelty-induced rearing in a dose-dependent manner. While the Coumaroyl derivative had no effect on novelty-induced rearing, it significantly reversed the inhibitory effect of yohimbine, propranolol and haloperidol on novelty-induced rearing. Quercetin significantly potentiated the inhibitory effect of yohimbine on novelty-induced rearing. Naloxone significantly potentiated the quercetin-induced suppression of novelty-induced rearing. Gallic acid derivative significantly potentiated the inhibitory effect of yohimbine on novelty-induced rearing. Naloxone, atropine and haloperidol pretreatments significantly potentiated gallic acid derivative-induced suppression of novelty-induced rearing.The extract and its fractions had biphasic effect on novelty-induced grooming in mice. Coumaroyl derivative significantly increased novelty-induced grooming, while quercetin and gallic acid derivative decreased novelty-induced grooming significantly. The three pure isolates significantly reversed the effects of yohimbine and atropine on the novelty-induced grooming in

  17. Analysis of pure maple syrup consumers

    Science.gov (United States)

    Paul E. Sendak

    1974-01-01

    Virtually all of the pure maple syrup productim in the United States is in the northern states of Maine, Massachusetts, Michigan, New Hampshire, New York, Ohio, Pennsylvania, Vermont, and Wisconsin. Pure maple syrup users living in the maple production area and users living in other areas of the United States were asked a series of questions about their use of pure...

  18. Microstructures and mechanical properties of pure Mg processed by rotary swaging

    International Nuclear Information System (INIS)

    Gan, W.M.; Huang, Y.D.; Wang, R.; Wang, G.F.; Srinivasan, A.; Brokmeier, H.-G.; Schell, N.; Kainer, K.U.; Hort, N.

    2014-01-01

    Highlights: • Grain size of pure Mg can be effectively reduced by rotary swaging processing. • The dominated texture of the swaged pure Mg was a basal fibre. • Twinning and non-basal plane sliding accommodated the swaging process. • Gradient texture distribution was observed through the rod diameter. • There existed a slight shear deformation on the surface of the swaged rod. - Abstract: Microstructures and tensile properties of commercial pure magnesium processed by rotary swaging (RS) technique were investigated. Bulk and gradient textures in the RS processed Mg were characterised by neutron and synchrotron diffractions, respectively. Grains of the pure Mg were gradually refined with increase in the RS passes, which largely contributed to an increase in the tensile yield strength. A dominated basal fibre texture was observed in the RS processed pure Mg. Accommodated twinning deformation was also observed. Both the optical observations and texture analyses through the diameter of the swaged rod showed a gradient evolution in microstructure

  19. High-resolution mapping of a fruit firmness-related quantitative trait locus in tomato reveals epistatic interactions associated with a complex combinatorial locus.

    Science.gov (United States)

    Chapman, Natalie H; Bonnet, Julien; Grivet, Laurent; Lynn, James; Graham, Neil; Smith, Rebecca; Sun, Guiping; Walley, Peter G; Poole, Mervin; Causse, Mathilde; King, Graham J; Baxter, Charles; Seymour, Graham B

    2012-08-01

    Fruit firmness in tomato (Solanum lycopersicum) is determined by a number of factors including cell wall structure, turgor, and cuticle properties. Firmness is a complex polygenic trait involving the coregulation of many genes and has proved especially challenging to unravel. In this study, a quantitative trait locus (QTL) for fruit firmness was mapped to tomato chromosome 2 using the Zamir Solanum pennellii interspecific introgression lines (ILs) and fine-mapped in a population consisting of 7,500 F2 and F3 lines from IL 2-3 and IL 2-4. This firmness QTL contained five distinct subpeaks, Fir(s.p.)QTL2.1 to Fir(s.p.)QTL2.5, and an effect on a distal region of IL 2-4 that was nonoverlapping with IL 2-3. All these effects were located within an 8.6-Mb region. Using genetic markers, each subpeak within this combinatorial locus was mapped to a physical location within the genome, and an ethylene response factor (ERF) underlying Fir(s.p.)QTL2.2 and a region containing three pectin methylesterase (PME) genes underlying Fir(s.p.)QTL2.5 were nominated as QTL candidate genes. Statistical models used to explain the observed variability between lines indicated that these candidates and the nonoverlapping portion of IL 2-4 were sufficient to account for the majority of the fruit firmness effects. Quantitative reverse transcription-polymerase chain reaction was used to quantify the expression of each candidate gene. ERF showed increased expression associated with soft fruit texture in the mapping population. In contrast, PME expression was tightly linked with firm fruit texture. Analysis of a range of recombinant lines revealed evidence for an epistatic interaction that was associated with this combinatorial locus.

  20. Effect of reciprocating agitation thermal processing (RA-TP) on quality of canned tomato (Solanum lycopersicum) puree.

    Science.gov (United States)

    Pratap Singh, Anubhav; Singh, Anika; Ramaswamy, Hosahalli S

    2017-06-01

    Reciprocating agitation thermal processing (RA-TP) is a recent innovation in the field of canning for obtaining high-quality canned food. The objective of this study was to compare RA-TP processing with conventional non-agitated (still) processing with respect to the impact on quality (color, antioxidant capacity, total phenols, carotenoid and lycopene contents) of canned tomato (Solanum lycopersicum) puree. Owing to a 63-81% reduction in process times as compared with still processing, tomato puree with a brighter red color (closer to fresh) was obtained during RA-TP. At 3 Hz reciprocation frequency, the loss of antioxidant, lycopene and carotenoid contents could be reduced to 34, 8 and 8% respectively as compared with 96, 41 and 52% respectively during still processing. In fact, the phenolic content for RA-TP at 3 Hz was 5% higher than in fresh puree. Quality retention generally increased with an increase in frequency, although the differences were less significant at higher reciprocation frequencies (between 2 and 3 Hz). Research findings indicate that RA-TP can be effective to obtain thermally processed foods with high-quality attribute retention. It can also be concluded that a very high reciprocation frequency (>3 Hz) is not necessarily needed and significant quality improvement can be obtained at lower frequencies (∼2 Hz). © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

  1. Fundamentals of the Pure Spinor Formalism

    CERN Document Server

    Hoogeveen, Joost

    2010-01-01

    This thesis presents recent developments within the pure spinor formalism, which has simplified amplitude computations in perturbative string theory, especially when spacetime fermions are involved. Firstly the worldsheet action of both the minimal and the non-minimal pure spinor formalism is derived from first principles, i.e. from an action with two dimensional diffeomorphism and Weyl invariance. Secondly the decoupling of unphysical states in the minimal pure spinor formalism is proved

  2. Effects of magnetic annealing on structure and multiferroic properties of pure and dysprosium substituted BiFeO 3

    KAUST Repository

    Zhang, Shuxia; Yao, Yingbang; Chen, Yao; Wang, Dongliang; Zhang, Xianping; Awaji, Satoshi; Watanabe, Kazuo; Ma, Yanwei

    2012-01-01

    In this work, the effects of magnetic annealing on crystal structure and multiferroic properties of BiFeO 3 and Bi 0.85Dy 0.15FeO 3 have been investigated. It is found that the X-ray diffraction patterns of pure BiFeO 3 samples are obviously broadened after magnetic annealing, whereas those of Bi 0.85Dy 0.15FeO 3 samples are almost unchanged. Magnetic field annealing did not affect the magnetic properties of these two kinds of samples much. However, ferroelectric properties of the two materials exhibited different behaviors after magnetic field annealing. For pure BiFeO 3 samples, the remnant polarizations (P r) are suppressed; in contrast, for Bi 0.85Dy 0.15FeO 3 samples, P r is greatly enhanced. Possible mechanisms for the effects of magnetic field annealing have been discussed. © 2012 Elsevier B.V. All rights reserved.

  3. Effects of magnetic annealing on structure and multiferroic properties of pure and dysprosium substituted BiFeO 3

    KAUST Repository

    Zhang, Shuxia

    2012-07-01

    In this work, the effects of magnetic annealing on crystal structure and multiferroic properties of BiFeO 3 and Bi 0.85Dy 0.15FeO 3 have been investigated. It is found that the X-ray diffraction patterns of pure BiFeO 3 samples are obviously broadened after magnetic annealing, whereas those of Bi 0.85Dy 0.15FeO 3 samples are almost unchanged. Magnetic field annealing did not affect the magnetic properties of these two kinds of samples much. However, ferroelectric properties of the two materials exhibited different behaviors after magnetic field annealing. For pure BiFeO 3 samples, the remnant polarizations (P r) are suppressed; in contrast, for Bi 0.85Dy 0.15FeO 3 samples, P r is greatly enhanced. Possible mechanisms for the effects of magnetic field annealing have been discussed. © 2012 Elsevier B.V. All rights reserved.

  4. Posterior magnetic effect on the pure and doped Fe-Ni alloy under neutron irradiation

    International Nuclear Information System (INIS)

    Ferreira, Iris

    1974-01-01

    Polycrystalline specimens of unirradiated and neutron irradiated Fe-Ni alloys have been studied in the temperature range RT - 500 deg C. The study was carried out in pure (50-50) as well as in Si, A1, Cr and Mo doped samples. Initial magnetic permeability was measured in unirradiated (virgin)and in neutron irradiated samples, during isochronal and linear thermal treatments. The main results are: a magnetic After Effect (MAE) is detected in the temperature range 370 deg C - Tc, where Tc is the Curie Temperature. In this range an activation energy of 3.2 ± 0.2 eV was determined for the Cr doped Fe-Ni alloy (impurity content: 0.1%); measurements made in the irradiated samples, during a linear temperature treatment, show the existence of several MAE zones in the temperature range RT - Tc. The isochronal annealing experiments show that these MAE zones are accompanied by a decrease in the room temperature value of the magnetic permeability, for zones between RT and a certain temperature T 1 . Above this range there is a steep increase in the room temperature permeability. Activation energies were determined for pure and Mo-doped (0.1%) samples for the first MAE zone (50 deg C - 120 deg C). The values obtained 1.25 - 0.08 eV and 1.42 ± 0.09 eV, respectively; the impurity - doped samples show a different behaviour relative to the pure ones: samples with low impurity content (0.1% and 0.5% of Si, Al or Mo) present an enhancement in the amplitude and also an overlapping of the diffusion stages. On the other hand, samples with higher impurity content (2 and 4% of Mo) show a decrease in these amplitudes. (author)

  5. Comparative in vitro biocompatibility of nickel-titanium, pure nickel, pure titanium, and stainless steel: genotoxicity and atomic absorption evaluation.

    Science.gov (United States)

    Assad, M; Lemieux, N; Rivard, C H; Yahia, L H

    1999-01-01

    The genotoxicity level of nickel-titanium (NiTi) was compared to that of its pure constituents, pure nickel (Ni) and pure titanium (Ti) powders, and also to 316L stainless steel (316L SS) as clinical reference material. In order to do so, a dynamic in vitro semiphysiological extraction was performed with all metals using agitation and ISO requirements. Peripheral blood lymphocytes were then cultured in the presence of all material extracts, and their comparative genotoxicity levels were assessed using electron microscopy-in situ end-labeling (EM-ISEL) coupled to immunogold staining. Cellular chromatin exposition to pure Ni and 316L SS demonstrated a significantly stronger gold binding than exposition to NiTi, pure Ti, or the untreated control. In parallel, graphite furnace atomic absorption spectrophotometry (AAS) was also performed on all extraction media. The release of Ni atoms took the following decreasing distribution for the different resulting semiphysiological solutions: pure Ni, 316L SS, NiTi, Ti, and controls. Ti elements were detected after elution of pure titanium only. Both pure titanium and nickel-titanium specimens obtained a relative in vitro biocompatibility. Therefore, this quantitative in vitro study provides optimistic results for the eventual use of nickel-titanium alloys as surgical implant materials.

  6. The effect of oil pulling with pure coconut oil on Streptococcus mutans: A randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Varsha Komath Pavithran

    2017-01-01

    Full Text Available Introduction: Oil pulling as described in ancient Ayurveda involves the use of edible vegetable oils as oral antibacterial agents. It is a practice of swishing oil in the mouth for oral and systemic health benefits. Pure coconut oil has antimicrobial properties and is commonly available in all Indian households. Aim: This study aims to assess the effect of oil pulling therapy with pure coconut oil on Streptococcus mutans count and to compare its efficacy against sesame oil and saline. Materials and Methods: A randomized controlled concurrent parallel- triple blinded clinical trial was conducted. Thirty participants in age range of 20–23 years were randomly allocated into Group A (coconut oil, Group B (sesame oil, and Group C (saline, with 10 in each group. The participants were instructed to swish and pull 10 ml of oil on empty stomach, early morning for 10–15 min. Unstimulated saliva collected before and after oil pulling procedure was analyzed for colony forming units (CFU per ml saliva of S. mutans. The data were analyzed using paired t-test, ANOVA, and post hoc analysis using Tukey's honest significant difference. Statistical significance was set at P < 0.05. Results: A statistically significant reduction in S. mutans CFU count after oil pulling with pure coconut oil (P = 0.001 was found. There was no statistically significant difference between sesame oil and coconut oil (P = 0.97 and between sesame oil and saline (P = 0.061. When efficacy of coconut oil against saline was evaluated, a statistical significant difference (P = 0.039 was found. Conclusion: Oil pulling is an effective method for oral hygiene maintenance as it significantly reduces S. mutans count in the saliva.

  7. Concurrence classes for general pure multipartite states

    International Nuclear Information System (INIS)

    Heydari, Hoshang

    2005-01-01

    We propose concurrence classes for general pure multipartite states based on an orthogonal complement of a positive operator-valued measure on quantum phase. In particular, we construct W m class, GHZ m , and GHZ m-1 class concurrences for general pure m-partite states. We give explicit expressions for W 3 and GHZ 3 class concurrences for general pure three-partite states and for W 4 , GHZ 4 and GHZ 3 class concurrences for general pure four-partite states

  8. Opposite Effects of the Spinach Food Matrix on Lutein Bioaccessibility and Intestinal Uptake Lead to Unchanged Bioavailability Compared to Pure Lutein.

    Science.gov (United States)

    Margier, Marielle; Buffière, Caroline; Goupy, Pascale; Remond, Didier; Halimi, Charlotte; Caris-Veyrat, Catherine; Borel, Patrick; Reboul, Emmanuelle

    2018-06-01

    Food matrix is generally believed to alter carotenoid bioavailability, but its effect on xanthophylls is usually limited. This study thus aims to decipher the digestion-absorption process of lutein in the presence or not of a food matrix. Lutein transfer to gastric-like lipid droplets or artificial mixed micelles was assessed when lutein was added to test meals either as a pure molecule ((all-E)-lutein) or in canned spinach ((Z) + (all-E)-lutein). The obtained mixed micelles were delivered to Caco-2 cells to evaluate lutein uptake. Finally postprandial plasma lutein responses were compared in minipigs after the two test meals. Lutein transfer to gastric-like lipid droplets and to mixed micelles was higher when lutein was added in spinach than when it was added as pure lutein (+614% and +147%, respectively, p < 0.05). Conversely, lutein uptake was less effective when micellar lutein was from a meal containing spinach than from a meal containing its pure form (-55%, p < 0.05). In minipigs, postprandial lutein response was delayed with spinach but not significantly different after the two test meals. Opposite effects at the micellarization and intestinal cell uptake steps explain the lack of effect of spinach matrix on lutein bioavailability. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Pressure-dependent pure- and mixed-gas permeation properties of Nafion®

    KAUST Repository

    Mukaddam, Mohsin Ahmed

    2016-04-20

    The permeation properties of Nafion® at 35 °C are presented for pure gases H2, N2, O2, CH4, CO2, C2H6 and C3H8, as a function of pressure between 2 and 20 atm. The effect of pressure on permeability and selectivity is analyzed to understand two observed phenomena: compression and plasticization. In pure-gas experiments, at increasing feed pressure, compression of the polymer matrix reduced the permeability of low-sorbing penetrants H2, N2, O2, and CH4. In contrast, permeabilities of more soluble penetrants CO2 and C2H6 increased by 18% and 46% respectively, as plasticization effects overcame compression effects. Permeability of C3H8 decreased slightly with increasing pressure up to 4.6 atm as a result of compression, then increased by 3-fold at 9 atm as a result of plasticization associated with high C3H8 solubility. Binary CO2/CH4 (50:50) mixed-gas experiments at total feed pressures up to 36 atm quantified the effect of CO2 plasticization on separation performance. At 10 atm CO2 partial pressure, CH4 permeability increased by 23% relative to its pure-gas value of 0.078 Barrer, while CO2 permeability decreased by 28%. Consequently, CO2/CH4 selectivity decreased to 19, i.e., 42% below its pure-gas value of 32.

  10. Quantum effects from a purely geometrical relativity theory

    International Nuclear Information System (INIS)

    Ellis, Homer G

    2005-01-01

    A purely geometrical relativity theory results from a construction that produces from three-dimensional space a happy unification of Kaluza's five-dimensional theory and Weyl's conformal theory. The theory can provide geometrical explanations for the following observed phenomena, among others: (a) visibility lifetimes of elementary particles of lengths inversely proportional to their rest masses; (b) the equality of charge magnitude among all charged particles interacting at an event; (c) the propensity of electrons in atoms to be seen in discretely spaced orbits; and (d) 'quantum jumps' between those orbits. This suggests the possibility that the theory can provide a deterministic underpinning of quantum mechanics like that provided to thermodynamics by the molecular theory of gases

  11. Polarized ensembles of random pure states

    Science.gov (United States)

    Deelan Cunden, Fabio; Facchi, Paolo; Florio, Giuseppe

    2013-08-01

    A new family of polarized ensembles of random pure states is presented. These ensembles are obtained by linear superposition of two random pure states with suitable distributions, and are quite manageable. We will use the obtained results for two purposes: on the one hand we will be able to derive an efficient strategy for sampling states from isopurity manifolds. On the other, we will characterize the deviation of a pure quantum state from separability under the influence of noise.

  12. chemf: A purely functional chemistry toolkit.

    Science.gov (United States)

    Höck, Stefan; Riedl, Rainer

    2012-12-20

    Although programming in a type-safe and referentially transparent style offers several advantages over working with mutable data structures and side effects, this style of programming has not seen much use in chemistry-related software. Since functional programming languages were designed with referential transparency in mind, these languages offer a lot of support when writing immutable data structures and side-effects free code. We therefore started implementing our own toolkit based on the above programming paradigms in a modern, versatile programming language. We present our initial results with functional programming in chemistry by first describing an immutable data structure for molecular graphs together with a couple of simple algorithms to calculate basic molecular properties before writing a complete SMILES parser in accordance with the OpenSMILES specification. Along the way we show how to deal with input validation, error handling, bulk operations, and parallelization in a purely functional way. At the end we also analyze and improve our algorithms and data structures in terms of performance and compare it to existing toolkits both object-oriented and purely functional. All code was written in Scala, a modern multi-paradigm programming language with a strong support for functional programming and a highly sophisticated type system. We have successfully made the first important steps towards a purely functional chemistry toolkit. The data structures and algorithms presented in this article perform well while at the same time they can be safely used in parallelized applications, such as computer aided drug design experiments, without further adjustments. This stands in contrast to existing object-oriented toolkits where thread safety of data structures and algorithms is a deliberate design decision that can be hard to implement. Finally, the level of type-safety achieved by Scala highly increased the reliability of our code as well as the productivity of

  13. Polarized ensembles of random pure states

    International Nuclear Information System (INIS)

    Cunden, Fabio Deelan; Facchi, Paolo; Florio, Giuseppe

    2013-01-01

    A new family of polarized ensembles of random pure states is presented. These ensembles are obtained by linear superposition of two random pure states with suitable distributions, and are quite manageable. We will use the obtained results for two purposes: on the one hand we will be able to derive an efficient strategy for sampling states from isopurity manifolds. On the other, we will characterize the deviation of a pure quantum state from separability under the influence of noise. (paper)

  14. Effects of Arsenite Resistance on the Growth and Functional Gene Expression of Leptospirillum ferriphilum and Acidithiobacillus thiooxidans in Pure Culture and Coculture

    Directory of Open Access Journals (Sweden)

    Huidan Jiang

    2015-01-01

    Full Text Available The response of iron-oxidizing Leptospirillum ferriphilum YSK and sulfur-oxidizing Acidithiobacillus thiooxidans A01 to arsenite under pure culture and coculture was investigated based on biochemical characterization (concentration of iron ion and pH value and related gene expression. L. ferriphilum YSK and At. thiooxidans A01 in pure culture could adapt up to 400 mM and 800 mM As(III after domestication, respectively, although arsenite showed a negative effect on both strains. The coculture showed a stronger sulfur and ferrous ion oxidation activity when exposed to arsenite. In coculture, the pH value showed no significant difference when under 500 mM arsenite stress, and the cell number of At. thiooxidans was higher than that in pure culture benefiting from the interaction with L. ferriphilum. The expression profile showed that the arsenic efflux system in the coculture was more active than that in pure culture, indicating that there is a synergetic interaction between At. thiooxidans A01 and L. ferriphilum YSK. In addition, a model was proposed to illustrate the interaction between arsenite and the ars operon in L. ferriphilum YSK and At. thiooxidans A01. This study will facilitate the effective application of coculture in the bioleaching process by taking advantage of strain-strain communication and coordination.

  15. Relativistic stars with purely toroidal magnetic fields

    International Nuclear Information System (INIS)

    Kiuchi, Kenta; Yoshida, Shijun

    2008-01-01

    We investigate the effects of the purely toroidal magnetic field on the equilibrium structures of the relativistic stars. The basic equations for obtaining equilibrium solutions of relativistic rotating stars containing purely toroidal magnetic fields are derived for the first time. To solve these basic equations numerically, we extend the Cook-Shapiro-Teukolsky scheme for calculating relativistic rotating stars containing no magnetic field to incorporate the effects of the purely toroidal magnetic fields. By using the numerical scheme, we then calculate a large number of the equilibrium configurations for a particular distribution of the magnetic field in order to explore the equilibrium properties. We also construct the equilibrium sequences of the constant baryon mass and/or the constant magnetic flux, which model the evolution of an isolated neutron star as it loses angular momentum via the gravitational waves. Important properties of the equilibrium configurations of the magnetized stars obtained in this study are summarized as follows: (1) For the nonrotating stars, the matter distribution of the stars is prolately distorted due to the toroidal magnetic fields. (2) For the rapidly rotating stars, the shape of the stellar surface becomes oblate because of the centrifugal force. But, the matter distribution deep inside the star is sufficiently prolate for the mean matter distribution of the star to be prolate. (3) The stronger toroidal magnetic fields lead to the mass shedding of the stars at the lower angular velocity. (4) For some equilibrium sequences of the constant baryon mass and magnetic flux, the stars can spin up as they lose angular momentum.

  16. Tensor modes in pure natural inflation

    Science.gov (United States)

    Nomura, Yasunori; Yamazaki, Masahito

    2018-05-01

    We study tensor modes in pure natural inflation [1], a recently-proposed inflationary model in which an axionic inflaton couples to pure Yang-Mills gauge fields. We find that the tensor-to-scalar ratio r is naturally bounded from below. This bound originates from the finiteness of the number of metastable branches of vacua in pure Yang-Mills theories. Details of the model can be probed by future cosmic microwave background experiments and improved lattice gauge theory calculations of the θ-angle dependence of the vacuum energy.

  17. Method of producing vegetable puree

    DEFF Research Database (Denmark)

    2004-01-01

    A process for producing a vegetable puree, comprising the sequential steps of: a)crushing, chopping or slicing the vegetable into pieces of 1 to 30 mm; b) blanching the vegetable pieces at a temperature of 60 to 90°C; c) contacted the blanched vegetable pieces with a macerating enzyme activity; d......) blending the macerated vegetable pieces and obtaining a puree....

  18. Capacitance evolution of electrochemical capacitors with tailored nanoporous electrodes in pure and dissolved ionic liquids

    Energy Technology Data Exchange (ETDEWEB)

    Mysyk, R.; Raymundo-Pinero, E. [CRMD, CNRS/University, Orleans (France); Ruiz, V.; Santamaria, R. [Instituto Nacional del Carbon (CSIC), Oviedo (Spain); Beguin, F.

    2010-10-15

    A homologous series of ionic liquids (IL) with 1-alkyl-3-methylimidazolium cations of different lengths of alkyl chain was used to study the effect of cation size on the capacitive response of two carbons with a tailored pore size distribution. The results reveal a clear ion-sieving effect in pure ILs, while the effect is heavily mitigated for the same salts used in solution, most likely due to somewhat stronger geometrical flexibility of dissolved ions. For the electrode material showing the ion-sieving effect in solution, the gravimetric capacitance values are higher than in pure ILs. The dissimilarity of capacitance values between pure and dissolved ILs with ion-sieving carbons highlights their respective advantages and disadvantages in terms of energy density: whereas pure ILs can potentially provide a larger working voltage window, the corresponding dissolved salts can access smaller pores, mostly contributing to higher capacitance values. (Abstract Copyright [2010], Wiley Periodicals, Inc.)

  19. ActionScript Developer's Guide to PureMVC

    CERN Document Server

    Hall, Cliff

    2011-01-01

    Gain hands-on experience with PureMVC, the popular open source framework for developing maintainable applications with a Model-View-Controller architecture. In this concise guide, PureMVC creator Cliff Hall teaches the fundamentals of PureMVC development by walking you through the construction of a complete non-trivial Adobe AIR application. Through clear explanations and numerous ActionScript code examples, you'll learn best practices for using the framework's classes in your day-to-day work. Discover how PureMVC enables you to focus on the purpose and scope of your application, while the f

  20. Effect of indentation size on the nucleation and propagation of tensile twinning in pure magnesium

    International Nuclear Information System (INIS)

    Sánchez-Martín, R.; Pérez-Prado, M.T.; Segurado, J.; Molina-Aldareguia, J.M.

    2015-01-01

    Tensile twinning is a key deformation mode in magnesium and its alloys, as well as in other hcp metals. However, the fundamentals of this mechanism are still not fully understood. In this research, instrumented nanoindentation and crystal plasticity finite element simulations are utilized to investigate twin formation and propagation in pure Mg. With that purpose, several nanoindentations at different indentation depths were performed in pure Mg single crystals with a wide range of crystallographic orientations. A careful analysis of the deformation profile, by atomic force microscopy, and of the microtexture, by electron backscatter diffraction, in areas around and underneath the indents, reveals that twinning is subjected to strong size effects, i.e., that the relative activity of twinning increases dramatically with the indentation depth. Furthermore, the twin volume fraction is found to be related to the pile-up or sink-in areas close to the indentations. A decrease in hardness in orientations where the twinning activity is high was confirmed both experimentally and by crystal plasticity finite element simulations. Finally, our results support the thesis that twin activation is an energetic process that demands a concentration of high stresses in a certain activation volume

  1. Investigations on the properties of pure and rare earth modified bismuth ferrite ceramics

    International Nuclear Information System (INIS)

    Kazhugasalamoorthy, S.; Jegatheesan, P.; Mohandoss, R.; Giridharan, N.V.; Karthikeyan, B.; Joseyphus, R. Justin; Dhanuskodi, S.

    2010-01-01

    Pure BiFeO 3 (BFO) and La-modified BiFeO 3 (Bi 1-x La x FeO 3 with x = 0.2 and 0.4) ceramic powders were synthesized at relatively low temperature by ferrioxalate precursor method. Pure compositions did not yield phase pure powders and contain secondary phases. At the same time, La-modification at different concentration levels in BFO promoted the formation of perovskite phase with the elimination of secondary phases and phase pure ceramic powders were obtained for the composition Bi 1-x La x FeO 3 with x = 0.4. Further, the effect of lanthanum substitution on the morphology, electrical and magnetic properties was also investigated.

  2. Casimir effect at finite temperature for pure-photon sector of the minimal Standard Model Extension

    Energy Technology Data Exchange (ETDEWEB)

    Santos, A.F., E-mail: alesandroferreira@fisica.ufmt.br [Instituto de Física, Universidade Federal de Mato Grosso, 78060-900, Cuiabá, Mato Grosso (Brazil); Department of Physics and Astronomy, University of Victoria, 3800 Finnerty Road Victoria, BC (Canada); Khanna, Faqir C., E-mail: khannaf@uvic.ca [Department of Physics and Astronomy, University of Victoria, 3800 Finnerty Road Victoria, BC (Canada)

    2016-12-15

    Dynamics between particles is governed by Lorentz and CPT symmetry. There is a violation of Parity (P) and CP symmetry at low levels. The unified theory, that includes particle physics and quantum gravity, may be expected to be covariant with Lorentz and CPT symmetry. At high enough energies, will the unified theory display violation of any symmetry? The Standard Model Extension (SME), with Lorentz and CPT violating terms, has been suggested to include particle dynamics. The minimal SME in the pure photon sector is considered in order to calculate the Casimir effect at finite temperature.

  3. Effects of alloying element on weld characterization of laser-arc hybrid welding of pure copper

    Science.gov (United States)

    Hao, Kangda; Gong, Mengcheng; Xie, Yong; Gao, Ming; Zeng, Xiaoyan

    2018-06-01

    Effects of alloying elements of Si and Sn on weld characterizations of laser-arc hybrid welded pure copper (Cu) with thickness of 2 mm was studied in detail by using different wires. The weld microstructure was analyzed, and the mechanical properties (micro-hardness and tensile property), conductivity and corrosion resistance were tested. The results showed that the alloying elements benefit the growth of column grains within weld fusion zone (FZ), increase the ultimate tensile strength (UTS) of the FZ and weld corrosion resistance, and decrease weld conductivity. The mechanisms were discussed according to the results.

  4. Excitation of coherent propagating spin waves by pure spin currents.

    Science.gov (United States)

    Demidov, Vladislav E; Urazhdin, Sergei; Liu, Ronghua; Divinskiy, Boris; Telegin, Andrey; Demokritov, Sergej O

    2016-01-28

    Utilization of pure spin currents not accompanied by the flow of electrical charge provides unprecedented opportunities for the emerging technologies based on the electron's spin degree of freedom, such as spintronics and magnonics. It was recently shown that pure spin currents can be used to excite coherent magnetization dynamics in magnetic nanostructures. However, because of the intrinsic nonlinear self-localization effects, magnetic auto-oscillations in the demonstrated devices were spatially confined, preventing their applications as sources of propagating spin waves in magnonic circuits using these waves as signal carriers. Here, we experimentally demonstrate efficient excitation and directional propagation of coherent spin waves generated by pure spin current. We show that this can be achieved by using the nonlocal spin injection mechanism, which enables flexible design of magnetic nanosystems and allows one to efficiently control their dynamic characteristics.

  5. Pure robotic retrocaval ureter repair

    Directory of Open Access Journals (Sweden)

    Ashok k. Hemal

    2008-12-01

    Full Text Available PURPOSE: To demonstrate the feasibility of pure robotic retrocaval ureter repair. MATERIALS AND METHODS: A 33 year old female presented with right loin pain and obstruction on intravenous urography with the classical "fish-hook" appearance. She was counseled on the various methods of repair and elected to have a robot assisted repair. The following steps are performed during a pure robotic retrocaval ureter repair. The patient is placed in a modified flank position, pneumoperitoneum created and ports inserted. The colon is mobilized to expose the retroperitoneal structures: inferior vena cava, right gonadal vein, right ureter, and duodenum. The renal pelvis and ureter are mobilized and the renal pelvis transected. The ureter is transposed anterior to the inferior vena cava and a pyelopyelostomy is performed over a JJ stent. RESULTS: This patient was discharged on postoperative day 3. The catheter and drain tube were removed on day 1. Her JJ stent was removed at 6 weeks postoperatively. The postoperative intravenous urography at 3 months confirmed normal drainage of contrast medium. CONCLUSION: Pure robotic retrocaval ureter is a feasible procedure; however, there does not appear to be any great advantage over pure laparoscopy, apart from the ergonomic ease for the surgeon as well the simpler intracorporeal suturing.

  6. Characterizing commercial pureed foods: sensory, nutritional, and textural analysis.

    Science.gov (United States)

    Ettinger, Laurel; Keller, Heather H; Duizer, Lisa M

    2014-01-01

    Dysphagia (swallowing impairment) is a common consequence of stroke and degenerative diseases such as Parkinson's and Alzheimer's. Limited research is available on pureed foods, specifically the qualities of commercial products. Because research has linked pureed foods, specifically in-house pureed products, to malnutrition due to inferior sensory and nutritional qualities, commercial purees also need to be investigated. Proprietary research on sensory attributes of commercial foods is available; however direct comparisons of commercial pureed foods have never been reported. Descriptive sensory analysis as well as nutritional and texture analysis of commercially pureed prepared products was performed using a trained descriptive analysis panel. The pureed foods tested included four brands of carrots, of turkey, and two of bread. Each commercial puree was analyzed for fat (Soxhlet), protein (Dumas), carbohydrate (proximate analysis), fiber (total fiber), and sodium content (Quantab titrator strips). The purees were also texturally compared with a line spread test and a back extrusion test. Differences were found in the purees for sensory attributes as well as nutritional and textural properties. Findings suggest that implementation of standards is required to reduce variability between products, specifically regarding the textural components of the products. This would ensure all commercial products available in Canada meet standards established as being considered safe for swallowing.

  7. Vacuum evaporation of pure metals

    OpenAIRE

    Safarian, Jafar; Engh, Thorvald Abel

    2013-01-01

    Theories on the evaporation of pure substances are reviewed and applied to study vacuum evaporation of pure metals. It is shown that there is good agreement between different theories for weak evaporation, whereas there are differences under intensive evaporation conditions. For weak evaporation, the evaporation coefficient in Hertz-Knudsen equation is 1.66. Vapor velocity as a function of the pressure is calculated applying several theories. If a condensing surface is less than one collision...

  8. Pure natural inflation

    Science.gov (United States)

    Nomura, Yasunori; Watari, Taizan; Yamazaki, Masahito

    2018-01-01

    We point out that a simple inflationary model in which the axionic inflaton couples to a pure Yang-Mills theory may give the scalar spectral index (ns) and tensor-to-scalar ratio (r) in complete agreement with the current observational data.

  9. Effect of ventricular size and function on exercise performance and the electrocardiogram in repaired tetralogy of Fallot with pure pulmonary regurgitation

    International Nuclear Information System (INIS)

    Menon, Shaji C; Kaza, Aditya K; Puchalski, Michael D

    2012-01-01

    In repaired tetralogy of Fallot (TOF), exercise test parameters like peak oxygen uptake and ventilatory efficiency predict mortality. Studies have also suggested cardiac magnetic resonance (CMR)-derived right ventricular (RV) size threshold values for pulmonary valve replacement in repaired TOF. However, effects of proposed RV size on exercise capacity and morbidity are not known. The relationship between CMR-derived ventricular size, function, and pulmonary regurgitation (PR) and NYHA class, exercise performance, and electrocardiogram (ECG) was studied in patients of repaired TOF with pure PR in a retrospective review of records. 46 patients (22 females), mean age 14 years (8–30.8), were studied. There was no relationship between CMR-derived ventricular size, function, or PR and exercise test parameters, or NYHA class. RV end systolic and end diastolic volume correlated positively with the degree of PR. QRS duration on ECG correlated positively with RV end-diastolic volume (P < 0.01, r 2 = 0.34) and PR (P < 0.01, r 2 = 0.52). In repaired TOF and pure PR, there is no correlation between ventricular size or function and exercise performance. RV size increases with increasing PR. Timing of pulmonary valve replacement in TOF with pure PR needs further prospective evaluation for its effect on morbidity and mortality

  10. Tribological Properties of Surface-Textured and Plasma-Nitrided Pure Titanium Under Oil Lubrication Condition

    Science.gov (United States)

    Zhang, Baosen; Dong, Qiangsheng; Ba, Zhixin; Wang, Zhangzhong; Shi, Hancheng; Xue, Yanting

    2018-01-01

    Plasma nitriding was conducted as post-treatment for surface texture on pure titanium to obtain a continuous nitriding layer. Supersonic fine particles bombarding (SFPB) was carried out to prepare surface texture. The surface morphologies and chemical composition were analyzed using scanning electron microscope and energy disperse spectroscopy. The microstructures of modified layers were characterized by transmission electron microscope. The tribological properties of surface-textured and duplex-treated pure titanium under oil lubrication condition were systematically investigated in the ball-on-plate reciprocating mode. The effects of applied load and sliding velocity on the tribological behavior were analyzed. The results show that after duplex treatments, the grains size in modified layer becomes slightly larger, and hardness is obviously improved. Wear resistance of duplex-treated pure titanium is significantly improved referenced to untreated and surface-textured pure titanium, which is 3.22 times as much as untreated pure titanium and 2.15 times of that for surface-textured pure titanium, respectively.

  11. Acute effect of pure oxygen breathing on diabetic macular edema

    DEFF Research Database (Denmark)

    Vinten, Carl Martin; La Cour, Morten; Lund-Andersen, Henrik

    2012-01-01

    Purpose. A small-scale pilot study of the pathophysiology of diabetic macular edema (DME) was made by assessing concomitant changes in macular volume (MV), mean arterial blood pressure (MABP), intraocular pressure (IOP), retinal artery diameter (RAD), and retinal vein diameter (RVD) in response...... diameters by fundus photography, intraocular pressure by pulse-air tonometry, and arterial blood pressure by sphygmomanometry. Results. After initiation of pure oxygen breathing, reductions of 2.6% in RAD (p=0.04) and 11.5% reduction in RVD (p...

  12. Conformal pure radiation with parallel rays

    International Nuclear Information System (INIS)

    Leistner, Thomas; Paweł Nurowski

    2012-01-01

    We define pure radiation metrics with parallel rays to be n-dimensional pseudo-Riemannian metrics that admit a parallel null line bundle K and whose Ricci tensor vanishes on vectors that are orthogonal to K. We give necessary conditions in terms of the Weyl, Cotton and Bach tensors for a pseudo-Riemannian metric to be conformal to a pure radiation metric with parallel rays. Then, we derive conditions in terms of the tractor calculus that are equivalent to the existence of a pure radiation metric with parallel rays in a conformal class. We also give analogous results for n-dimensional pseudo-Riemannian pp-waves. (paper)

  13. Beyond the single gene: How epistasis and gene-by-environment effects influence crop domestication.

    Science.gov (United States)

    Doust, Andrew N; Lukens, Lewis; Olsen, Kenneth M; Mauro-Herrera, Margarita; Meyer, Ann; Rogers, Kimberly

    2014-04-29

    Domestication is a multifaceted evolutionary process, involving changes in individual genes, genetic interactions, and emergent phenotypes. There has been extensive discussion of the phenotypic characteristics of plant domestication, and recent research has started to identify the specific genes and mutational mechanisms that control domestication traits. However, there is an apparent disconnect between the simple genetic architecture described for many crop domestication traits, which should facilitate rapid phenotypic change under selection, and the slow rate of change reported from the archeobotanical record. A possible explanation involves the middle ground between individual genetic changes and their expression during development, where gene-by-gene (epistatic) and gene-by-environment interactions can modify the expression of phenotypes and opportunities for selection. These aspects of genetic architecture have the potential to significantly slow the speed of phenotypic evolution during crop domestication and improvement. Here we examine whether epistatic and gene-by-environment interactions have shaped how domestication traits have evolved. We review available evidence from the literature, and we analyze two domestication-related traits, shattering and flowering time, in a mapping population derived from a cross between domesticated foxtail millet and its wild progenitor. We find that compared with wild progenitor alleles, those favored during domestication often have large phenotypic effects and are relatively insensitive to genetic background and environmental effects. Consistent selection should thus be able to rapidly change traits during domestication. We conclude that if phenotypic evolution was slow during crop domestication, this is more likely due to cultural or historical factors than epistatic or environmental constraints.

  14. Epistatic interaction between haplotypes of the ghrelin ligand and receptor genes influence susceptibility to myocardial infarction and coronary artery disease.

    Science.gov (United States)

    Baessler, Andrea; Fischer, Marcus; Mayer, Bjoern; Koehler, Martina; Wiedmann, Silke; Stark, Klaus; Doering, Angela; Erdmann, Jeanette; Riegger, Guenter; Schunkert, Heribert; Kwitek, Anne E; Hengstenberg, Christian

    2007-04-15

    itself. However, we found an effect of GHRL dependent upon the presence of a common, MI and CAD susceptible haplotype of GHSR. Thus, our data suggest that specific haplotypes of the ghrelin ligand and its receptor act epistatically to affect susceptibility or tolerance to MI and/or CAD.

  15. Pure spinor partition function and the massive superstring spectrum

    International Nuclear Information System (INIS)

    Aisaka, Yuri; Arroyo, E. Aldo; Berkovits, Nathan; Nekrasov, Nikita

    2008-01-01

    We explicitly compute up to the fifth mass-level the partition function of ten-dimensional pure spinor worldsheet variables including the spin dependence. After adding the contribution from the (x μ , θ α , p α ) matter variables, we reproduce the massive superstring spectrum. Even though pure spinor variables are bosonic, the pure spinor partition function contains fermionic states which first appear at the second mass-level. These fermionic states come from functions which are not globally defined in pure spinor space, and are related to the b ghost in the pure spinor formalism. This result clarifies the proper definition of the Hilbert space for pure spinor variables.

  16. Assessing the microstructural and rheological changes induced by food additives on potato puree.

    Science.gov (United States)

    Dankar, Iman; Haddarah, Amira; El Omar, Fawaz; Sepulcre, Francesc; Pujolà, Montserrat

    2018-02-01

    The effects of agar, alginate, lecithin and glycerol on the rheological properties of commercial potato puree were investigated and interpreted in terms of starch microstructural changes, and the applicability of the Cox-Merz rule was evaluated. Each additive was applied separately at two concentrations (0.5 and 1%). Microscopic observations revealed more swollen starch aggregations in lecithin and glycerol compared with those of potato puree and agar, consequently affecting the rheological properties of potato puree. All samples exhibited shear thinning non-Newtonian behaviour. Rheological measurements were strongly concentration dependent. At 0.5% concentration, additives exerted decreases in all the rheological properties of potato puree in the order of glycerol>alginate>lecithin>agar, while at 1% concentration, the order changed to glycerol>lecithin>alginate, whereas 1% agar behaved differently, increasing all rheological values. This study also showed that agar and alginate in addition to potato puree could be valuable and advantageous for further technological processes, such as 3D printing. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. POEM: Identifying joint additive effects on regulatory circuits

    Directory of Open Access Journals (Sweden)

    Maya eBotzman

    2016-04-01

    Full Text Available Motivation: Expression Quantitative Trait Locus (eQTL mapping tackles the problem of identifying variation in DNA sequence that have an effect on the transcriptional regulatory network. Major computational efforts are aimed at characterizing the joint effects of several eQTLs acting in concert to govern the expression of the same genes. Yet, progress towards a comprehensive prediction of such joint effects is limited. For example, existing eQTL methods commonly discover interacting loci affecting the expression levels of a module of co-regulated genes. Such ‘modularization’ approaches, however, are focused on epistatic relations and thus have limited utility for the case of additive (non-epistatic effects.Results: Here we present POEM (Pairwise effect On Expression Modules, a methodology for identifying pairwise eQTL effects on gene modules. POEM is specifically designed to achieve high performance in the case of additive joint effects. We applied POEM to transcription profiles measured in bone marrow-derived dendritic cells across a population of genotyped mice. Our study reveals widespread additive, trans-acting pairwise effects on gene modules, characterizes their organizational principles, and highlights high-order interconnections between modules within the immune signaling network. These analyses elucidate the central role of additive pairwise effect in regulatory circuits, and provide computational tools for future investigations into the interplay between eQTLs.Availability: The software described in this article is available at csgi.tau.ac.il/POEM/.

  18. Development and evaluation of 'Pure Rush': An online serious game for drug education.

    Science.gov (United States)

    Stapinski, Lexine A; Reda, Bill; Newton, Nicola C; Lawler, Siobhan; Rodriguez, Daniel; Chapman, Catherine; Teesson, Maree

    2018-04-01

    Learning is most effective when it is active, enjoyable and incorporates feedback. Past research demonstrates that serious games are prime candidates to utilise these principles, however the potential benefits of this approach for delivering drug education are yet to be examined in Australia, a country where drug education in schools is mandatory. The serious game 'Pure Rush' was developed across three stages. First, formative consultation was conducted with 115 students (67% male, aged 15-17 years), followed by feasibility and acceptability testing of a prototype of the game (n = 25, 68% male). In the final stage, 281 students (62% female, aged 13-16 years) were randomly allocated to receive a lesson involving Pure Rush or an active control lesson. The lessons were compared in terms of learning outcomes, lesson engagement and future intentions to use illicit drugs. Students enjoyed playing Pure Rush, found the game age-appropriate and the information useful to them. Both the Pure Rush and the active control were associated with significant knowledge increase from pre to post-test. Among females, multi-level mixed-effects regression showed knowledge gain was greater in the Pure Rush condition compared to control (β = 2.36, 95% confidence interval 0.36-4.38). There was no evidence of between condition differences in lesson engagement or future intentions to use illicit drugs. Pure Rush is an innovative online drug education game that is well received by students and feasible to implement in schools. [Stapinski LA, Reda B, Newton NC, Lawler S, Rodriguez D, Chapman C, Teesson M. Development and evaluation of 'Pure Rush': An online serious game for drug education. Drug Alcohol Rev 2017]. © 2017 Australasian Professional Society on Alcohol and other Drugs.

  19. Gate-Driven Pure Spin Current in Graphene

    Science.gov (United States)

    Lin, Xiaoyang; Su, Li; Si, Zhizhong; Zhang, Youguang; Bournel, Arnaud; Zhang, Yue; Klein, Jacques-Olivier; Fert, Albert; Zhao, Weisheng

    2017-09-01

    The manipulation of spin current is a promising solution for low-power devices beyond CMOS. However, conventional methods, such as spin-transfer torque or spin-orbit torque for magnetic tunnel junctions, suffer from large power consumption due to frequent spin-charge conversions. An important challenge is, thus, to realize long-distance transport of pure spin current, together with efficient manipulation. Here, the mechanism of gate-driven pure spin current in graphene is presented. Such a mechanism relies on the electrical gating of carrier-density-dependent conductivity and spin-diffusion length in graphene. The gate-driven feature is adopted to realize the pure spin-current demultiplexing operation, which enables gate-controllable distribution of the pure spin current into graphene branches. Compared with the Elliott-Yafet spin-relaxation mechanism, the D'yakonov-Perel spin-relaxation mechanism results in more appreciable demultiplexing performance. The feature of the pure spin-current demultiplexing operation will allow a number of logic functions to be cascaded without spin-charge conversions and open a route for future ultra-low-power devices.

  20. Pure natural inflation

    Directory of Open Access Journals (Sweden)

    Yasunori Nomura

    2018-01-01

    Full Text Available We point out that a simple inflationary model in which the axionic inflaton couples to a pure Yang–Mills theory may give the scalar spectral index (ns and tensor-to-scalar ratio (r in complete agreement with the current observational data.

  1. Pure spin current manipulation in antiferromagnetically exchange coupled heterostructures

    Science.gov (United States)

    Avilés-Félix, L.; Butera, A.; González-Chávez, D. E.; Sommer, R. L.; Gómez, J. E.

    2018-03-01

    We present a model to describe the spin currents generated by ferromagnet/spacer/ferromagnet exchange coupled trilayer systems and heavy metal layers with strong spin-orbit coupling. By exploiting the magnitude of the exchange coupling (oscillatory RKKY-like coupling) and the spin-flop transition in the magnetization process, it has been possible to produce spin currents polarized in arbitrary directions. The spin-flop transition of the trilayer system originates pure spin currents whose polarization vector depends on the exchange field and the magnetization equilibrium angles. We also discuss a protocol to control the polarization sign of the pure spin current injected into the metallic layer by changing the initial conditions of magnetization of the ferromagnetic layers previously to the spin pumping and inverse spin Hall effect experiments. The small differences in the ferromagnetic layers lead to a change in the magnetization vector rotation that permits the control of the sign of the induced voltage components due to the inverse spin Hall effect. Our results can lead to important advances in hybrid spintronic devices with new functionalities, particularly, the ability to control microscopic parameters such as the polarization direction and the sign of the pure spin current through the variation of macroscopic parameters, such as the external magnetic field or the thickness of the spacer in antiferromagnetic exchange coupled systems.

  2. Computer Pure-Tone and Operator Stress: Report III.

    Science.gov (United States)

    Dow, Caroline; Covert, Douglas C.

    Pure-tone sound at 15,750 Herz generated by flyback transformers in many computer and video display terminal (VDT) monitors has stress-related productivity effects in some operators, especially women. College-age women in a controlled experiment simulating half a normal work day showed responses within the first half hour of exposure to a tone…

  3. Pure chiral optical fibres.

    Science.gov (United States)

    Poladian, L; Straton, M; Docherty, A; Argyros, A

    2011-01-17

    We investigate the properties of optical fibres made from chiral materials, in which a contrast in optical activity forms the waveguide, rather than a contrast in the refractive index; we refer to such structures as pure chiral fibres. We present a mathematical formulation for solving the modes of circularly symmetric examples of such fibres and examine the guidance and polarisation properties of pure chiral step-index, Bragg and photonic crystal fibre designs. Their behaviour is shown to differ for left- and right-hand circular polarisation, allowing circular polarisations to be isolated and/or guided by different mechanisms, as well as differing from equivalent non-chiral fibres. The strength of optical activity required in each case is quantified.

  4. Effect of bicarbonate on biodegradation behaviour of pure magnesium in a simulated body fluid

    International Nuclear Information System (INIS)

    Li, Zaichun; Song, Guang-Ling; Song, Shizhe

    2014-01-01

    The effect of bicarbonate on biodegradation of pure magnesium in a simulated body fluid is investigated by means of X-ray diffraction, X-ray photoelectron spectroscopy, polarization curve and electrochemical impedance spectroscopy. The results show that magnesium biodegrades rapidly and non-uniformly during 27 h of immersion in four simulated body fluid solutions containing different concentrations of bicarbonate. The biodegradation rate first decreases and then increases with time. A small amount of bicarbonate in simulated body fluid has an inhibition effect on the Mg dissolution, while an overdose of bicarbonate addition activates the magnesium surface in the simulated body fluid. The interesting phenomena can be interpreted by a surface film model involving precipitation of calcium carbonate and further ionization of bicarbonate in the simulated body fluids, incorporation of calcium, carbonate and phosphate compounds in the surface film, and development of chloride-induced pitting corrosion damage on the magnesium with time

  5. Budding yeast mms4 is epistatic with rad52 and the function of Mms4 can be replaced by a bacterial Holliday junction resolvase.

    Science.gov (United States)

    Odagiri, Nao; Seki, Masayuki; Onoda, Fumitoshi; Yoshimura, Akari; Watanabe, Sei; Enomoto, Takemi

    2003-03-01

    MMS4 of Saccharomyces cerevisiae was originally identified as the gene responsible for one of the collection of methyl methanesulfonate (MMS)-sensitive mutants, mms4. Recently it was identified as a synthetic lethal gene with an SGS1 mutation. Epistatic analyses revealed that MMS4 is involved in a pathway leading to homologous recombination requiring Rad52 or in the recombination itself, in which SGS1 is also involved. MMS sensitivity of mms4 but not sgs1, was suppressed by introducing a bacterial Holliday junction (HJ) resolvase, RusA. The frequencies of spontaneously occurring unequal sister chromatid recombination (SCR) and loss of marker in the rDNA in haploid mms4 cells and interchromosomal recombination between heteroalleles in diploid mms4 cells were essentially the same as those of wild-type cells. Although UV- and MMS-induced interchromosomal recombination was defective in sgs1 diploid cells, hyper-induction of interchromosomal recombination was observed in diploid mms4 cells, indicating that the function of Mms4 is dispensable for this type of recombination.

  6. Environmental stresses can alleviate the average deleterious effect of mutations

    Directory of Open Access Journals (Sweden)

    Leibler Stanislas

    2003-05-01

    Full Text Available Abstract Background Fundamental questions in evolutionary genetics, including the possible advantage of sexual reproduction, depend critically on the effects of deleterious mutations on fitness. Limited existing experimental evidence suggests that, on average, such effects tend to be aggravated under environmental stresses, consistent with the perception that stress diminishes the organism's ability to tolerate deleterious mutations. Here, we ask whether there are also stresses with the opposite influence, under which the organism becomes more tolerant to mutations. Results We developed a technique, based on bioluminescence, which allows accurate automated measurements of bacterial growth rates at very low cell densities. Using this system, we measured growth rates of Escherichia coli mutants under a diverse set of environmental stresses. In contrast to the perception that stress always reduces the organism's ability to tolerate mutations, our measurements identified stresses that do the opposite – that is, despite decreasing wild-type growth, they alleviate, on average, the effect of deleterious mutations. Conclusions Our results show a qualitative difference between various environmental stresses ranging from alleviation to aggravation of the average effect of mutations. We further show how the existence of stresses that are biased towards alleviation of the effects of mutations may imply the existence of average epistatic interactions between mutations. The results thus offer a connection between the two main factors controlling the effects of deleterious mutations: environmental conditions and epistatic interactions.

  7. On the importance of PURE - Public Understanding of Renewable Energy

    Energy Technology Data Exchange (ETDEWEB)

    Broman, Lars; Kandpal, Tara C.

    2013-09-15

    Public understanding of science (PUS) is a central concept among science communicators. Public understanding of renewable energy (PURE) is proposed as an important sub-concept of PUS. The aim of this paper is to interest and invite renewable energy scientists to join a PURE research project. Four separate important questions for a PURE research project can be identified: (A) Is PURE important? (B) Which issues of PURE are the most important ones, according to renewable energy scientists? (C) What understanding of renewable energy has the general public today, worldwide? (D) How to achieve PURE?.

  8. Bi-orderings on pure braided Thompson's groups

    OpenAIRE

    Burillo, Jose; Gonzalez-Meneses, Juan

    2006-01-01

    In this paper it is proved that the pure braided Thompson’s group BF admits a bi-order, analog to the bi-order of the pure braid groups. Ministerio de Educación y Ciencia Fondo Europeo de Desarrollo Regional

  9. Effect of Magnesium Hydride on the Corrosion Behavior of Pure Magnesium in 0.1 M NaCl Solution

    OpenAIRE

    Xu, Shanna; Dong, Junhua; Ke, Wei

    2010-01-01

    The effect of magnesium hydride on the corrosion behavior of pure magnesium in 0.1 M NaCl solution was investigated using the gas collection method, potentiostatic current decay test, and in situ Raman spectrum. The formation of magnesium hydride (MgH2, Mg2H4) was observed at the cathodic region. Applying anodic potential leads to decomposition of magnesium hydride. Magnesium hydride plays an important role on the negative difference effect (NDE) in both the cathodic and anodic regions.

  10. Isotopically pure single crystal epitaxial diamond films and their preparation

    International Nuclear Information System (INIS)

    Banholzer, W.F.; Anthony, T.R.; Williams, D.M.

    1992-01-01

    The present invention is directed to the production of single crystal diamond consisting of isotopically pure carbon-12 or carbon-13. In the present invention, isotopically pure single crystal diamond is grown on a single crystal substrate directly from isotopically pure carbon-12 or carbon-13. One method for forming isotopically pure single crystal diamond comprises the steps of placing in a reaction chamber a single substrate heated to an elevated diamond forming temperature. Another method for forming isotopically pure single crystal diamond comprises diffusing isotopically pure carbon-12 or carbon-13 through a metallic catalyst under high pressure to a region containing a single crystal substrate to form an isotopically pure single crystal diamond layer on said single crystal substrate

  11. Notes on the ambitwistor pure spinor string

    Czech Academy of Sciences Publication Activity Database

    Lipinski Jusinskas, Renann

    2016-01-01

    Roč. 2016, č. 5 (2016), s. 1-12, č. článku 116. ISSN 1029-8479 R&D Projects: GA ČR GBP201/12/G028 Institutional support: RVO:68378271 Keywords : ambitwistor string * pure spinor formalism Subject RIV: BE - Theoretical Physics OBOR OECD: Atomic, molecular and chemical physics (physics of atoms and molecules including collision, interaction with radiation, magnetic resonances, Mössbauer effect) Impact factor: 6.063, year: 2016

  12. Effects of neutron irradiation on microstructure and mechanical properties of pure iron

    DEFF Research Database (Denmark)

    Singh, B.N.; Horsewell, Andy; Toft, P.

    1999-01-01

    electron microscope. Results of these investigations are reported and discussed particularly in terms of the role of interstitial clusters (produced directly in the cascades) and their transport via one-dimensional glide. It is suggested that the formation and interaction of 'cleared' channels may play...... a significant role in determining the deformation and fracture behaviour of the irradiated pure iron....

  13. Texture and Microtexture of Pure (6N and Commercially Pure Aluminum after Deformation by Extrusion with Forward-Backward Rotating Die (Kobo

    Directory of Open Access Journals (Sweden)

    Bieda M.

    2016-03-01

    Full Text Available Pure aluminium (6N and commercially pure aluminium (99.7 was deformed by KOBO method. Microstructure and texture of both materials after deformation was analyzed by means of scanning and transmission electron microscopy. Advanced methods of crystallographic orientations measurements like Electron Backscatter Diffraction - EBSD (SEM and microdiffraction (TEM was used. Grain size distribution and misorientation between grains in cross and longitudinal sections of the samples were analyzed. Differences in size and homogeneity of the grains were observed in both materials. Pure aluminium was characterized by larger grain size in both sections of extruded material. Whereas commercially pure aluminium reveals smaller grain size and more homogeneous and stable microstructure.

  14. Structural and optical properties of pure and copper doped zinc oxide nanoparticles

    Science.gov (United States)

    Sajjad, Muhammad; Ullah, Inam; Khan, M. I.; Khan, Jamshid; Khan, M. Yaqoob; Qureshi, Muhammad Tauseef

    2018-06-01

    Pure and copper-doped zinc oxide nanoparticles (NPs) have been synthesized via chemical co-precipitation method where hydrazine is used as reducing agent and aqueous extract of Euphorbia milii plant as capping agent. Main objectives of the reported work are to investigate the effect of copper doping on crystal structure of ZnO nanoparticles; to study the effect of copper doping on optical band gap of ZnO nanoparticles and photoluminescence (PL) study of pure and copper-doped ZnO nanoparticles. To achieve the aforementioned objectives, XRD and SEM tests were performed for the identification and confirmation of crystal structure and morphology of the prepared samples. From XRD data the average grain size for pure ZnO was observed to be 24.62 nm which was first decreased to 18.95 nm for 5 wt% Cu-doped sample and then it was found to increase up to 37.80 nm as the Cu doping was increased to 7 wt%. Optical band gap of pure and Cu-doped ZnO nanoparticles was calculated from diffuse reflectance spectroscopy (DRS) spectra and was found to decrease from 3.13 eV to 2.94 eV as the amount of Cu increases up to 7 wt%. In photoluminescence study, PL technique was used and enhanced visible spectrum was observed. For further characterization FT-IR and EDX tests were also carried out.

  15. Effect of Magnesium Hydride on the Corrosion Behavior of Pure Magnesium in 0.1 M NaCl Solution

    Directory of Open Access Journals (Sweden)

    Shanna Xu

    2010-01-01

    Full Text Available The effect of magnesium hydride on the corrosion behavior of pure magnesium in 0.1 M NaCl solution was investigated using the gas collection method, potentiostatic current decay test, and in situ Raman spectrum. The formation of magnesium hydride (MgH2, Mg2H4 was observed at the cathodic region. Applying anodic potential leads to decomposition of magnesium hydride. Magnesium hydride plays an important role on the negative difference effect (NDE in both the cathodic and anodic regions.

  16. Lectures on the theory of pure motives

    CERN Document Server

    Murre, Jacob P; A, Chris

    2013-01-01

    The theory of motives was created by Grothendieck in the 1960s as he searched for a universal cohomology theory for algebraic varieties. The theory of pure motives is well established as far as the construction is concerned. Pure motives are expected to have a number of additional properties predicted by Grothendieck's standard conjectures, but these conjectures remain wide open. The theory for mixed motives is still incomplete. This book deals primarily with the theory of pure motives. The exposition begins with the fundamentals: Grothendieck's construction of the category of pure motives and examples. Next, the standard conjectures and the famous theorem of Jannsen on the category of the numerical motives are discussed. Following this, the important theory of finite dimensionality is covered. The concept of Chow-K�nneth decomposition is introduced, with discussion of the known results and the related conjectures, in particular the conjectures of Bloch-Beilinson type. We finish with a chapter on relative m...

  17. Pure thermal sensitisation and pre-dose effect of OSL in both unfired and annealed quartz samples

    Energy Technology Data Exchange (ETDEWEB)

    Oniya, Ebenezer O., E-mail: ebenezer.oniya@aaua.edu.ng [Physics and Electronics Department, Adekunle Ajasin University, 342111 Akungba Akoko (Nigeria); Polymeris, George S. [Institute of Nuclear Sciences, Ankara University, Beşevler 06100, Ankara (Turkey); Jibiri, Nnamdi N. [Department of Physics, University of Ibadan, Ibadan (Nigeria); Tsirliganis, Nestor C. [Department of Archaeometry and Physicochemical Measurements, R.C. ‘Athena’, P.O. Box 159, Kimmeria University Campus, 67100 Xanthi (Greece); Babalola, Israel A. [Department of Physics, University of Ibadan, Ibadan (Nigeria); Kitis, George [Nuclear Physics Laboratory, Department of Physics, Aristotle University of Thessaloniki, 54124 Thessaloniki (Greece)

    2017-06-01

    The sensitisation of quartz has attracted much attention since its thorough understanding is important in luminescence studies and dating applications. The present investigation examines the influence of pure thermal activation and predose treatments on the sensitisation of different components of linearly modulated optically stimulated luminescence (LM-OSL) measured at room temperature (RT) thereby eliminating undesired thermal quenching effects. Annealed and unfired quartz samples from Nigeria were used. The OSL measurements were carried out using an automated RISØTL/OSL reader (model-TL/OSL–DA–15). A new approach was adopted to match each of the resolved components of the RT-LM-OSL to respective thermoluminescence (TL) peaks that share the same electron trap and recombination centers. Pure thermal activation and pre-dose treatments respectively affect the sensitisation of all the components of the RT-LM-OSL in a similar manner as the one reported for the 110 °C TL peak but without thermal quenching contributions. Component C4 in annealed samples that was identified to share the same electron trap and recombination centers with the 110 °C TL peak was also proved appropriate for RT-LM-OSL, instead of the initial part of the continuous wave (CW) OSL signal, thus the methods can serve as complementary dating methods.

  18. Pure thermal sensitisation and pre-dose effect of OSL in both unfired and annealed quartz samples

    International Nuclear Information System (INIS)

    Oniya, Ebenezer O.; Polymeris, George S.; Jibiri, Nnamdi N.; Tsirliganis, Nestor C.; Babalola, Israel A.; Kitis, George

    2017-01-01

    The sensitisation of quartz has attracted much attention since its thorough understanding is important in luminescence studies and dating applications. The present investigation examines the influence of pure thermal activation and predose treatments on the sensitisation of different components of linearly modulated optically stimulated luminescence (LM-OSL) measured at room temperature (RT) thereby eliminating undesired thermal quenching effects. Annealed and unfired quartz samples from Nigeria were used. The OSL measurements were carried out using an automated RISØTL/OSL reader (model-TL/OSL–DA–15). A new approach was adopted to match each of the resolved components of the RT-LM-OSL to respective thermoluminescence (TL) peaks that share the same electron trap and recombination centers. Pure thermal activation and pre-dose treatments respectively affect the sensitisation of all the components of the RT-LM-OSL in a similar manner as the one reported for the 110 °C TL peak but without thermal quenching contributions. Component C4 in annealed samples that was identified to share the same electron trap and recombination centers with the 110 °C TL peak was also proved appropriate for RT-LM-OSL, instead of the initial part of the continuous wave (CW) OSL signal, thus the methods can serve as complementary dating methods.

  19. Pure energy solutions - pure tomorrows

    International Nuclear Information System (INIS)

    Allison, J.

    2006-01-01

    HTC is an energy technology company whose mandate is to deliver 'Carbon Clear Solutions' to address the pending challenges the energy sector is facing in meeting the environmental impact of Greenhouse Gas emissions, and energy security. HTC will speak on its comprehensive suite of technologies including hydrogen production, CO 2 capture and CO 2 sequestration. HTC has patented technologies that produce H 2 from a broad variety of feedstocks such as Natural gas, Diesel, Gasoline, Bio-fuels i.e. ethanol, methanol and Coal Gasification. HTC Hydrogen reformation systems are unique in their method of delivering pure Hydrogen. Dry Reformation Reactor - New catalyst system designed to eliminate contamination problems (i.e. coking) while at the same time operate at a low temperature. Water Gas Shift Reactor - Plus - improved and redesigned catalyst that improves operating temperature and hydrogen production efficiency. Two stage catalyst reactor that provides near balance of the endothermic and exothermic reaction temperatures for efficient energy balance

  20. Pure γ-families

    International Nuclear Information System (INIS)

    Dunaevskii, A.M.

    1977-01-01

    The subject of this work are pure gamma families consisting of the gamma quanta produced in the early stages of cosmic cascades. The criteria of selecting these families from the all measured families are presented. The characteristics of these families are given and some conclusions about the mechanism of the nuclear-electromagnetic cascades are extracted. (S.B.)

  1. Pure drug nanoparticles in tablets: what are the dissolution limitations?

    International Nuclear Information System (INIS)

    Heng, Desmond; Ogawa, Keiko; Cutler, David J.; Chan, Hak-Kim; Raper, Judy A.; Ye Lin; Yun, Jimmy

    2010-01-01

    There has been increasing interests for drug companies to incorporate drug nanoparticles into their existing formulations. However, technical knowledge in this area is still in its infancy and more study needs to be done to stimulate growth in this fledging field. There is a need to scrutinize the performance of pure drug nanoparticles in tablets, particularly relating formulation variables to their dissolution performance. Application of the pure form, synthesized without the use of surfactants or stabilizers, is often preferred to maximize drug loading and also to minimize toxicity. Cefuroxime axetil, a poorly water-soluble cephalosporin antibiotic, was used as the model drug in the formulation development. Drug release rate, tablet disintegration time, tensile strength and energy of failure were predominantly influenced by the amount of super-disintegrant, amount of surfactant, compression force and diluent species, respectively. The compression rate had minimal impact on the responses. The main hurdle confronting the effective use of pure drug nanoparticles in tablets is the difficulty in controlling aggregation in solution, which could potentially be aggravated by the tabletting process. Through the use of elevated levels of surfactants (8 w/w% sodium dodecyl sulphate), drug release from the nanoparticle preparation was enhanced from 58.0 ± 2.7% to 72.3 ± 0.7% in 10 min. Hence, it is recommended that physical formulations for pure drug nanoparticles be focused on the particle de-aggregation step in solution, if much higher rates are to be desired. In conclusion, even though pure drug nanoparticles could be easily synthesized, limitations from aggregation may need to be overcome, before successful application in tablets can be fully realized.

  2. Pure drug nanoparticles in tablets: what are the dissolution limitations?

    Energy Technology Data Exchange (ETDEWEB)

    Heng, Desmond [Institute of Chemical and Engineering Sciences (Singapore); Ogawa, Keiko [Nitto Denko Co. Ltd., Medical Division (Japan); Cutler, David J.; Chan, Hak-Kim, E-mail: kimc@pharm.usyd.edu.a [University of Sydney, Advanced Drug Delivery Group, Faculty of Pharmacy, A15 (Australia); Raper, Judy A. [University of Wollongong, Vice Chancellor' s Unit (Australia); Ye Lin [University of Sydney, School of Aerospace, Mechanical and Mechatronic Engineering (Australia); Yun, Jimmy [Nanomaterials Technology Pty. Ltd. (Singapore)

    2010-06-15

    There has been increasing interests for drug companies to incorporate drug nanoparticles into their existing formulations. However, technical knowledge in this area is still in its infancy and more study needs to be done to stimulate growth in this fledging field. There is a need to scrutinize the performance of pure drug nanoparticles in tablets, particularly relating formulation variables to their dissolution performance. Application of the pure form, synthesized without the use of surfactants or stabilizers, is often preferred to maximize drug loading and also to minimize toxicity. Cefuroxime axetil, a poorly water-soluble cephalosporin antibiotic, was used as the model drug in the formulation development. Drug release rate, tablet disintegration time, tensile strength and energy of failure were predominantly influenced by the amount of super-disintegrant, amount of surfactant, compression force and diluent species, respectively. The compression rate had minimal impact on the responses. The main hurdle confronting the effective use of pure drug nanoparticles in tablets is the difficulty in controlling aggregation in solution, which could potentially be aggravated by the tabletting process. Through the use of elevated levels of surfactants (8 w/w% sodium dodecyl sulphate), drug release from the nanoparticle preparation was enhanced from 58.0 {+-} 2.7% to 72.3 {+-} 0.7% in 10 min. Hence, it is recommended that physical formulations for pure drug nanoparticles be focused on the particle de-aggregation step in solution, if much higher rates are to be desired. In conclusion, even though pure drug nanoparticles could be easily synthesized, limitations from aggregation may need to be overcome, before successful application in tablets can be fully realized.

  3. Pure drug nanoparticles in tablets: what are the dissolution limitations?

    Science.gov (United States)

    Heng, Desmond; Ogawa, Keiko; Cutler, David J.; Chan, Hak-Kim; Raper, Judy A.; Ye, Lin; Yun, Jimmy

    2010-06-01

    There has been increasing interests for drug companies to incorporate drug nanoparticles into their existing formulations. However, technical knowledge in this area is still in its infancy and more study needs to be done to stimulate growth in this fledging field. There is a need to scrutinize the performance of pure drug nanoparticles in tablets, particularly relating formulation variables to their dissolution performance. Application of the pure form, synthesized without the use of surfactants or stabilizers, is often preferred to maximize drug loading and also to minimize toxicity. Cefuroxime axetil, a poorly water-soluble cephalosporin antibiotic, was used as the model drug in the formulation development. Drug release rate, tablet disintegration time, tensile strength and energy of failure were predominantly influenced by the amount of super-disintegrant, amount of surfactant, compression force and diluent species, respectively. The compression rate had minimal impact on the responses. The main hurdle confronting the effective use of pure drug nanoparticles in tablets is the difficulty in controlling aggregation in solution, which could potentially be aggravated by the tabletting process. Through the use of elevated levels of surfactants (8 w/w% sodium dodecyl sulphate), drug release from the nanoparticle preparation was enhanced from 58.0 ± 2.7% to 72.3 ± 0.7% in 10 min. Hence, it is recommended that physical formulations for pure drug nanoparticles be focused on the particle de-aggregation step in solution, if much higher rates are to be desired. In conclusion, even though pure drug nanoparticles could be easily synthesized, limitations from aggregation may need to be overcome, before successful application in tablets can be fully realized.

  4. Effects of the breed, sex and age on cellular content and growth factor release from equine pure-platelet rich plasma and pure-platelet rich gel.

    Science.gov (United States)

    Giraldo, Carlos E; López, Catalina; Álvarez, María E; Samudio, Ismael J; Prades, Marta; Carmona, Jorge U

    2013-02-12

    There is no information on the effects of the breed, gender and age on the cellular content and growth factor (GF) release from equine pure-platelet rich plasma (P-PRP) and pure-platelet rich gel (P-PRG). The objectives of this study were: 1) to compare the cellular composition of P-PRP with whole blood and platelet poor plasma (PPP); 2) to compare the concentration of transforming GF beta 1 (TGF-β1) and platelet derived GF isoform BB (PDGF-BB) between P-PRP treated with non-ionic detergent (P-PRP+NID), P-PRG (activated with calcium gluconate -CG-), PPP+NID, PPP gel (PPG), and plasma and; 3) to evaluate and to correlate the effect of the breed, gender and age on the cellular and GF concentration for each blood component. Forty adult horses, 20 Argentinean Creole Horses (ACH) and, 20 Colombian Creole Horses (CCH) were included. Data were analyzed by parametric (i.e.: t-test, one way ANOVA) and non parametric (Kruskal-Wallis test, Wilcoxon test) tests. Correlation analysis was also performed by using the Spearman and Pearson tests. A p ≤ 0.05 was set as significant for all tests. All the blood components were compared for platelet (PLT), leukocyte (WBC), TGF-β1 and PDGF-BB concentrations. The effect of the breed, gender and age on these variables was analyzed. A P ≤ 0.05 was accepted as significant for all the tests. PLT counts were 1.8 and 0.6 times higher in P-PRP than in whole blood and PPP, respectively; WBC counts were 0.5 and 0.1 times lower in P-PRP, in comparison with whole blood and PPP, respectively. TGF-β1 and PDGF-BB concentrations were 2.3 and 262 times higher, respectively, in P-PRG than in plasma, and 0.59 and 0.48 times higher, respectively, in P-PRG than in PPG. P-PRG derived from CCH females or young horses presented significantly (P < 0.001) higher PDGF-BB concentrations than P-PRG derived from ACH males or older horses. Our results indicated that P-PRP obtained by a manual method was affected by intrinsic factors such as the breed

  5. Effects of the breed, sex and age on cellular content and growth factor release from equine pure-platelet rich plasma and pure-platelet rich gel

    Directory of Open Access Journals (Sweden)

    Giraldo Carlos E

    2013-02-01

    Full Text Available Abstract Background There is no information on the effects of the breed, gender and age on the cellular content and growth factor (GF release from equine pure-platelet rich plasma (P-PRP and pure-platelet rich gel (P-PRG. The objectives of this study were: 1 to compare the cellular composition of P-PRP with whole blood and platelet poor plasma (PPP; 2 to compare the concentration of transforming GF beta 1 (TGF-β1 and platelet derived GF isoform BB (PDGF-BB between P-PRP treated with non-ionic detergent (P-PRP+NID, P-PRG (activated with calcium gluconate -CG-, PPP+NID, PPP gel (PPG, and plasma and; 3 to evaluate and to correlate the effect of the breed, gender and age on the cellular and GF concentration for each blood component. Forty adult horses, 20 Argentinean Creole Horses (ACH and, 20 Colombian Creole Horses (CCH were included. Data were analyzed by parametric (i.e.: t-test, one way ANOVA and non parametric (Kruskal-Wallis test, Wilcoxon test tests. Correlation analysis was also performed by using the Spearman and Pearson tests. A p ≤ 0.05 was set as significant for all tests. All the blood components were compared for platelet (PLT, leukocyte (WBC, TGF-β1 and PDGF-BB concentrations. The effect of the breed, gender and age on these variables was analyzed. A P ≤ 0.05 was accepted as significant for all the tests. Results PLT counts were 1.8 and 0.6 times higher in P-PRP than in whole blood and PPP, respectively; WBC counts were 0.5 and 0.1 times lower in P-PRP, in comparison with whole blood and PPP, respectively. TGF-β1 and PDGF-BB concentrations were 2.3 and 262 times higher, respectively, in P-PRG than in plasma, and 0.59 and 0.48 times higher, respectively, in P-PRG than in PPG. P-PRG derived from CCH females or young horses presented significantly (P Conclusions Our results indicated that P-PRP obtained by a manual method was affected by intrinsic factors such as the breed, gender and age. Equine practitioners should be

  6. Pure endmember extraction using robust kernel archetypoid analysis for hyperspectral imagery

    Science.gov (United States)

    Sun, Weiwei; Yang, Gang; Wu, Ke; Li, Weiyue; Zhang, Dianfa

    2017-09-01

    A robust kernel archetypoid analysis (RKADA) method is proposed to extract pure endmembers from hyperspectral imagery (HSI). The RKADA assumes that each pixel is a sparse linear mixture of all endmembers and each endmember corresponds to a real pixel in the image scene. First, it improves the re8gular archetypal analysis with a new binary sparse constraint, and the adoption of the kernel function constructs the principal convex hull in an infinite Hilbert space and enlarges the divergences between pairwise pixels. Second, the RKADA transfers the pure endmember extraction problem into an optimization problem by minimizing residual errors with the Huber loss function. The Huber loss function reduces the effects from big noises and outliers in the convergence procedure of RKADA and enhances the robustness of the optimization function. Third, the random kernel sinks for fast kernel matrix approximation and the two-stage algorithm for optimizing initial pure endmembers are utilized to improve its computational efficiency in realistic implementations of RKADA, respectively. The optimization equation of RKADA is solved by using the block coordinate descend scheme and the desired pure endmembers are finally obtained. Six state-of-the-art pure endmember extraction methods are employed to make comparisons with the RKADA on both synthetic and real Cuprite HSI datasets, including three geometrical algorithms vertex component analysis (VCA), alternative volume maximization (AVMAX) and orthogonal subspace projection (OSP), and three matrix factorization algorithms the preconditioning for successive projection algorithm (PreSPA), hierarchical clustering based on rank-two nonnegative matrix factorization (H2NMF) and self-dictionary multiple measurement vector (SDMMV). Experimental results show that the RKADA outperforms all the six methods in terms of spectral angle distance (SAD) and root-mean-square-error (RMSE). Moreover, the RKADA has short computational times in offline

  7. Effects of the pure flavonoids epicatechin and quercetin on vascular function and cardiometabolic health: a randomized double-blind, placebo-controlled, crossover trial

    OpenAIRE

    Dower, J.I.; Geleijnse, J.M.; Gijsbers, L.; Zock, P.L.; Kromhout, D.; Hollman, P.C.H.

    2015-01-01

    BACKGROUND: Prospective cohort studies showed inverse associations between the intake of flavonoid-rich foods (cocoa and tea) and cardiovascular disease (CVD). Intervention studies showed protective effects on intermediate markers of CVD. This may be due to the protective effects of the flavonoids epicatechin (in cocoa and tea) and quercetin (in tea). OBJECTIVE: We investigated the effects of supplementation of pure epicatechin and quercetin on vascular function and cardiometabolic health. DE...

  8. Pure spinor integration from the collating formula

    International Nuclear Information System (INIS)

    Grassi, P.A.; Sommovigo, L.

    2011-01-01

    We use the technique developed by Becchi and Imbimbo to construct a well-defined BRST-invariant path integral formulation of pure spinor amplitudes. The space of pure spinors can be viewed from the algebraic geometry point of view as a collection of open sets where the constraints can be solved and a set of free and independent variables can be defined. On the intersections of those open sets, the functional measure jumps and one has to add boundary terms to construct a well-defined path integral. The result is the definition of the pure spinor integration measure constructed in terms of differential forms on each single patch.

  9. Pure and Pseudo-pure Fluid Thermophysical Property Evaluation and the Open-Source Thermophysical Property Library CoolProp

    DEFF Research Database (Denmark)

    Bell, Ian H.; Wronski, Jorrit; Quoilin, Sylvain

    2014-01-01

    property correlations described here have been implemented into CoolProp, an open-source thermophysical property library. This library is written in C++, with wrappers available for the majority of programming languages and platforms of technical interest. As of publication, 110 pure and pseudo-pure fluids...... are included in the library, as well as properties of 40 incompressible fluids and humid air. The source code for the CoolProp library is included as an electronic annex....

  10. Nigeria Journal of Pure and Applied Physics

    African Journals Online (AJOL)

    Nigeria Journal of Pure and Applied Physics publishes papers of the highest quality and significance in specific areas of physics, pure and applied, as listed below. The journal content reflects core physics disciplines, but is also open to a broad range of topics whose central theme falls within the bounds of physics.

  11. Three-dimensional investigation of grain orientation effects on void growth in commercially pure titanium

    International Nuclear Information System (INIS)

    Pushkareva, Marina; Adrien, Jérôme; Maire, Eric; Segurado, Javier; Llorca, Javier; Weck, Arnaud

    2016-01-01

    The fracture process of commercially pure titanium was visualized in model materials containing artificial holes. These model materials were fabricated using a femtosecond laser coupled with a diffusion bonding technique to obtain voids in the interior of titanium samples. Changes in void dimensions during in-situ straining were recorded in three dimensions using x-ray computed tomography. Void growth obtained experimentally was compared with the Rice and Tracey model which predicted well the average void growth. A large scatter in void growth data was explained by differences in grain orientation which was confirmed by crystal plasticity simulations. It was also shown that grain orientation has a stronger effect on void growth than intervoid spacing and material strength. Intervoid spacing, however, appears to control whether the intervoid ligament failure is ductile or brittle.

  12. Three-dimensional investigation of grain orientation effects on void growth in commercially pure titanium

    Energy Technology Data Exchange (ETDEWEB)

    Pushkareva, Marina [Department of Mechanical Engineering, University of Ottawa, 150 Louis Pasteur, Ottawa, ON, Canada K1N 6N5 (Canada); Adrien, Jérôme; Maire, Eric [Université de Lyon, INSA-Lyon, MATEIS CNRS UMR5510, 7 Avenue Jean Capelle, F-69621 Villeurbanne (France); Segurado, Javier; Llorca, Javier [IMDEA Materials Institute, C/Eric Kandel 2, 28906 Getafe, Madrid (Spain); Department of Materials Science, Polytechnic University of Madrid, E. T. S. de Ingenieros de Caminos, 28040 Madrid (Spain); Weck, Arnaud, E-mail: aweck@uottawa.ca [Department of Mechanical Engineering, University of Ottawa, 150 Louis Pasteur, Ottawa, ON, Canada K1N 6N5 (Canada); IMDEA Materials Institute, C/Eric Kandel 2, 28906 Getafe, Madrid (Spain); Department of Physics, University of Ottawa, 150 Louis Pasteur, Ottawa, ON, Canada K1N 6N5 (Canada); Centre for Research in Photonics at the University of Ottawa, 800 King Edward Ave., Ottawa, ON, Canada K1N 6N5 (Canada)

    2016-08-01

    The fracture process of commercially pure titanium was visualized in model materials containing artificial holes. These model materials were fabricated using a femtosecond laser coupled with a diffusion bonding technique to obtain voids in the interior of titanium samples. Changes in void dimensions during in-situ straining were recorded in three dimensions using x-ray computed tomography. Void growth obtained experimentally was compared with the Rice and Tracey model which predicted well the average void growth. A large scatter in void growth data was explained by differences in grain orientation which was confirmed by crystal plasticity simulations. It was also shown that grain orientation has a stronger effect on void growth than intervoid spacing and material strength. Intervoid spacing, however, appears to control whether the intervoid ligament failure is ductile or brittle.

  13. Refurbishment of JMTR pure water facility

    International Nuclear Information System (INIS)

    Asano, Norikazu; Hanakawa, Hiroki; Kusunoki, Hidehiko; Satou, Shinichi

    2012-05-01

    In the refurbishment of JMTR, facilities were classified into which (1) were all updated, (2) were partly updated, and (3) were continuance used by the considerations of the maintenance history, the change parts availability and the latest technology. The JMTR pure water facility was classified into all updated facility based on the consideration. The Update construction was conducted in between FY2007 and FY2008. The refurbishment of JMTR pure water facility is summarized in this report. (author)

  14. Kinetic Effects in the Self-Assembly of Pure and Mixed Tetradecyland Octadecylamine Molecules on Mica

    Energy Technology Data Exchange (ETDEWEB)

    Benitez, J.J.; Salmeron, M.

    2005-09-21

    The self-assembly of tetradecylamine (C14) and of mixtures of tetradecyl and octadecylamine (C18) molecules from chloroform solutions on mica has been studied using atomic force microscopy(AFM). For pure components self-assembly proceeds more slowly for C14 than for C18. In both cases after equilibrium is reached islands of tilted molecules cover a similar fraction of the surface. Images of films formed by mixtures of molecules acquired before equilibrium is reached (short ripening time at room temperature) show only islands with the height corresponding to C18 with many pores. After a long ripening time, when equilibrium is reached, islands of segregated pure components are formed.

  15. Effect of carrot puree edible films on quality preservation of fresh-cut carrots

    Directory of Open Access Journals (Sweden)

    Wang X.

    2015-06-01

    Full Text Available The effect of edible films based on carrot puree, chitosan, corn starch, gelatin, glycerol and cinnamaldehyde on fresh-cut carrots was studied during storage. Several parameters, such as firmness, colour, weight loss, total carotenoids, total phenols, polyphenol oxidase (PPO activity and peroxidase (POD activity in coated carrots were determined at regular intervals and then compared with the uncoated carrots throughout the storage period. Significant and expected changes were observed in all carrot samples that were compared. The coating treatment significantly (P < 0.05 delayed the senescence, reduced the deterioration of exterior quality and retained total carotenoids well compared with control (P < 0.05. In addition, significant inhibition of PPO activity (P < 0.05 and POD activity (P < 0.05 as well as reduced accumulation of polyphenols (P < 0.05 were observed for all coated samples. All of these favourable responses induced by coating treatment on minimally processed fresh-cut carrots showed beneficial physiological effects, which would give some useful references to the fresh-cut fruit and vegetable processing industry and satisfy people’s requirements allowing for extending product shelf life without negatively affecting the sensory quality or acceptability.

  16. Enzymatic cell wall degradation of high-pressure-homogenized tomato puree and its effect on lycopene bioaccessibility.

    Science.gov (United States)

    Palmero, Paola; Colle, Ines; Lemmens, Lien; Panozzo, Agnese; Nguyen, Tuyen Thi My; Hendrickx, Marc; Van Loey, Ann

    2016-01-15

    High-pressure homogenization disrupts cell structures, assisting carotenoid release from the matrix and subsequent micellarization. However, lycopene bioaccessibility of tomato puree upon high-pressure homogenization is limited by the formation of a process-induced barrier. In this context, cell wall-degrading enzymes were applied to hydrolyze the formed barrier and enhance lycopene bioaccessibility. The effectiveness of the enzymes in degrading their corresponding substrates was evaluated (consistency, amount of reducing sugars, molar mass distribution and immunolabeling). An in vitro digestion procedure was applied to evaluate the effect of the enzymatic treatments on lycopene bioaccessibility. Enzymatic treatments with pectinases and cellulase were proved to effectively degrade their corresponding cell wall polymers; however, no further significant increase in lycopene bioaccessibility was obtained. A process-induced barrier consisting of cell wall material is not the only factor governing lycopene bioaccessibility upon high-pressure homogenization. © 2015 Society of Chemical Industry.

  17. Archives: Bayero Journal of Pure and Applied Sciences

    African Journals Online (AJOL)

    Items 1 - 20 of 20 ... Archives: Bayero Journal of Pure and Applied Sciences. Journal Home > Archives: Bayero Journal of Pure and Applied Sciences. Log in or Register to get access to full text downloads.

  18. Archives: Nigeria Journal of Pure and Applied Physics

    African Journals Online (AJOL)

    Items 1 - 6 of 6 ... Archives: Nigeria Journal of Pure and Applied Physics. Journal Home > Archives: Nigeria Journal of Pure and Applied Physics. Log in or Register to get access to full text downloads.

  19. Improving quality of an innovative pea puree by high hydrostatic pressure.

    Science.gov (United States)

    Klug, Tâmmila Venzke; Martínez-Sánchez, Ascensión; Gómez, Perla A; Collado, Elena; Aguayo, Encarna; Artés, Francisco; Artés-Hernández, Francisco

    2017-10-01

    The food industry is continuously innovating to fulfill consumer demand for new, healthy, ready-to-eat products. Pea purees could satisfy this trend by increasing the intake of legumes, which are an important source of nutrients. Moreover, sensorial properties like viscosity could be improved by high hydrostatic pressure (HHP). In this study the effect of a boiling treatment (10 min) followed by HHP at 550 kPa (0, 5 or 10 min) on the rheological properties, associated with enzymatic activity and particle size, as well as on the microbial and sensory quality of a pea-based puree stored for 36 days at 5 °C, has been assessed. The particle size of pea puree decreased after all processing treatments, but increased during storage in HHP-treated samples. Conversely, boiling treatment showed an increase in polygalacturonase activity at the end of the storage period, with a decrease in particle size, viscosity and stability. However, 5 min of 550 kPa HHP showed the highest mean particle size, mean surface diameter and viscosity regarding the remaining treatments. The microbial load remained low during storage. HHP treatment can be used by the food industry to improve the rheological properties, viscosity and stability of pea purees. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  20. Thermomechanical characterization of pure polycrystalline tantalum

    International Nuclear Information System (INIS)

    Rittel, D.; Bhattacharyya, A.; Poon, B.; Zhao, J.; Ravichandran, G.

    2007-01-01

    The thermomechanical behavior of pure polycrystalline tantalum has been characterized over a wide range of strain rates, using the recently developed shear compression specimen [D. Rittel, S. Lee, G. Ravichandran, Experimental Mechanics 42 (2002) 58-64]. Dynamic experiments were carried out using a split Hopkinson pressure bar, and the specimen's temperature was monitored throughout the tests using an infrared radiometer. The results of the mechanical tests confirm previous results on pure Ta. Specifically, in addition to its significant strain rate sensitivity, it was observed that pure Ta exhibits very little strain hardening at high strain rates. The measured temperature rise in the specimen's gauge was compared to theoretical predictions which assume a total conversion of the mechanical energy into heat (β = 1) [G.I. Taylor, H. Quinney, Proceedings of the Royal Society of London, vol. A, 1934, pp. 307-326], and an excellent agreement was obtained. This result confirms the previous result of Kapoor and Nemat-Nasser [R. Kapoor, S. Nemat-Nasser, Mech. Mater. 27 (1998) 1-12], while a different experimental approach was adopted here. The assumption that β = 1 is found to be justified in this specific case by the lack of dynamic strain hardening of pure Ta. However, this assumption should be limited to non-hardening materials, to reflect the fact that strain hardening implies that part of the mechanical energy is stored into the material's microstructure

  1. Study on growth of highly pure uranium compounds

    International Nuclear Information System (INIS)

    Shikama, Tatsuo; Ochiai, Akira; Suzuki, Kenji.

    1992-01-01

    We developed the systems for growing highly pure uranium compounds to study their intrinsic physical properties. Uranium metal was zone refined under low contamination conditions as far as possible. Chemical analysis of the purified uranium was performed using the inductive coupled plasma emission spectrometry (ICP). The problem that emission spectra of the uranium conceal those of analyzed impurities was settled by extraction of the uranium using tri-n-butyl-phosphate (TBP). The result shows that some metallic impurities such as Pb, Mn, Cu etc. evaporated by the r.f. heating and other usual metallic impurities moved to the end of rod with molten zone. Therefore, we conclude that the zone refining technique is much effective to the removal of metallic impurities and we obtained highly purified uranium metal of 99.99 % up with regard to metallic impurities. Using the purified uranium, we attempted to grow a highly pure uranium-titanium single crystals. (author)

  2. Effects of sodium citrate and acid citrate dextrose solutions on cell counts and growth factor release from equine pure-platelet rich plasma and pure-platelet rich gel.

    Science.gov (United States)

    Giraldo, Carlos E; Álvarez, María E; Carmona, Jorge U

    2015-03-14

    There is a lack information on the effects of the most commonly used anticoagulants for equine platelet rich plasmas (PRPs) elaboration on cell counts and growth factor release from platelet rich gels (PRGs). The aims of this study were 1) to compare the effects of the anticoagulants sodium citrate (SC), acid citrate dextrose solution A (ACD-A) and ACD-B on platelet (PLT), leukocyte (WBC) and on some parameters associated to platelet activation including mean platelet volume (MPV) and platelet distribution width (PDW) between whole blood, pure PRP (P-PRP) and platelet-poor plasma (PPP); 2) to compare transforming growth factor beta 1 (TGF-β(1)) and platelet-derived growth factor isoform BB (PDGF-BB) concentrations in supernatants from pure PRG (P-PRG), platelet-poor gel (PPG), P-PRP lysate (positive control) and plasma (negative control); 3) to establish the possible correlations between all the studied cellular and molecular parameters. In all cases the three anticoagulants produced P-PRPs with significantly higher PLT counts compared with whole blood and PPP. The concentrations of WBCs were similar between P-PRP and whole blood, but significantly lower in PPP. The type of anticoagulant did not significantly affect the cell counts for each blood component. The anticoagulants also did not affect the MPV and PDW parameters. Independently of the anticoagulant used, all blood components presented significantly different concentrations of PDGF-BB and TGF-β(1). The highest growth factor (GF) concentrations were observed from P-PRP lysates, followed by PRG supernatants, PPP lysates, PPG supernatants and plasma. Significant correlations were observed between PLT and WBC counts (ρ = 0.80), PLT count and TGF-β(1) concentration (ρ = 0.85), PLT count and PDGF-BB concentration (ρ = 0.80) and PDGF-BB and TGF-β(1) concentrations (ρ = 0.75). The type of anticoagulant was not correlated with any of the variables evaluated. The anticoagulants did not

  3. Biocorrosion properties and blood and cell compatibility of pure iron as a biodegradable biomaterial.

    Science.gov (United States)

    Zhang, Erlin; Chen, Haiyan; Shen, Feng

    2010-07-01

    Biocorrosion properties and blood- and cell compatibility of pure iron were studied in comparison with 316L stainless steel and Mg-Mn-Zn magnesium alloy to reveal the possibility of pure iron as a biodegradable biomaterial. Both electrochemical and weight loss tests showed that pure iron showed a relatively high corrosion rate at the first several days and then decreased to a low level during the following immersion due to the formation of phosphates on the surface. However, the corrosion of pure iron did not cause significant increase in pH value to the solution. In comparison with 316L and Mg-Mn-Zn alloy, the pure iron exhibited biodegradable property in a moderate corrosion rate. Pure iron possessed similar dynamic blood clotting time, prothrombin time and plasma recalcification time to 316L and Mg-Mn-Zn alloy, but a lower hemolysis ratio and a significant lower number density of adhered platelets. MTT results revealed that the extract except the one with 25% 24 h extract actually displayed toxicity to cells and the toxicity increased with the increasing of the iron ion concentration and the incubation time. It was thought there should be an iron ion concentration threshold in the effect of iron ion on the cell toxicity.

  4. [Inhibition of Bacillus coagulans growth in laboratory media and in fruit purees].

    Science.gov (United States)

    Cerrutti, P; Alzamora, S M; de Huergo, M S

    2000-01-01

    The growth of two strains of B. coagulans was inhibited in laboratory media at pH banana puree (pH approximately equal to 5.0) but acidification of the puree at pH = 3.5 was enough to prevent growth. The addition of up to 3,000 ppm vainillin ("natural" preservative) or 1,000 ppm potassium sorbate (traditional preservative) at pH higher than the inhibitory level previously determined could not prevent growth of B. coagulans in laboratory or in fruits, but 100 ppm lysozyme retarded growth in laboratory media at different pH levels (from 4.5 to 6.7) and in banana puree. As lysozyme showed to be effective at pH < or = 6.7, it might be used to prevent growth of B. coagulans at an eventual increment of pH during storage.

  5. Pure transvaginal excision of mesh erosion involving the bladder.

    Science.gov (United States)

    Firoozi, Farzeen; Goldman, Howard B

    2013-06-01

    We present a pure transvaginal approach to the removal of eroded mesh involving the bladder secondary to placement of transvaginal mesh for management of pelvic organ prolapse (POP) using a mesh kit. Although technically challenging, we demonstrate the feasibility of a purely transvaginal approach, avoiding a potentially more morbid transabdominal approach. The video presents the surgical technique of pure transvaginal excision of mesh erosion involving the bladder after mesh placement using a prolapse kit was performed. This video shows that purely transvaginal removal of mesh erosion involving the bladder can be done safely and is feasible.

  6. Magnetization oscillations and waves driven by pure spin currents

    Energy Technology Data Exchange (ETDEWEB)

    Demidov, V.E. [Institute for Applied Physics and Center for Nanotechnology, University of Muenster, Corrensstrasse 2-4, 48149 Muenster (Germany); Urazhdin, S. [Department of Physics, Emory University, Atlanta, GA 30322 (United States); Loubens, G. de [SPEC, CEA, CNRS, Université Paris-Saclay, CEA Saclay, 91191 Gif-sur-Yvette (France); Klein, O. [INAC-SPINTEC, CEA/CNRS and Univ. Grenoble Alpes, 38000 Grenoble (France); Cros, V.; Anane, A. [Unité Mixte de Physique CNRS, Thales, Univ. Paris Sud, Université Paris-Saclay, 91767 Palaiseau (France); Demokritov, S.O., E-mail: demokrit@uni-muenster.de [Institute for Applied Physics and Center for Nanotechnology, University of Muenster, Corrensstrasse 2-4, 48149 Muenster (Germany); Institute of Metal Physics, Ural Division of RAS, Yekaterinburg 620041 (Russian Federation)

    2017-02-23

    Recent advances in the studies of pure spin currents–flows of angular momentum (spin) not accompanied by the electric currents–have opened new horizons for the emerging technologies based on the electron’s spin degree of freedom, such as spintronics and magnonics. The main advantage of pure spin current, as compared to the spin-polarized electric current, is the possibility to exert spin transfer torque on the magnetization in thin magnetic films without the electrical current flow through the material. In addition to minimizing Joule heating and electromigration effects, this enables the implementation of spin torque devices based on the low-loss insulating magnetic materials, and offers an unprecedented geometric flexibility. Here we review the recent experimental achievements in investigations of magnetization oscillations excited by pure spin currents in different nanomagnetic systems based on metallic and insulating magnetic materials. We discuss the spectral properties of spin-current nano-oscillators, and relate them to the spatial characteristics of the excited dynamic magnetic modes determined by the spatially-resolved measurements. We also show that these systems support locking of the oscillations to external microwave signals, as well as their mutual synchronization, and can be used as efficient nanoscale sources of propagating spin waves.

  7. Progeny-testing of full-sibs IBD in a SSC2 QTL region highlights epistatic interactions for fatness traits in pigs

    Directory of Open Access Journals (Sweden)

    Iannuccelli Nathalie

    2011-10-01

    Full Text Available Abstract Background Many QTL have been detected in pigs, but very few of them have been fine-mapped up to the causal mutation. On SSC2, the IGF2-intron3-G3072A mutation has been described as the causative polymorphism for a QTL underlying muscle mass and backfat deposition, but further studies have demonstrated that at least one additional QTL should segregate downstream of this mutation. A marker-assisted backcrossing design was set up in order to confirm the segregation of this second locus, reduce its confidence interval and better understand its mode of segregation. Results Five recombinant full-sibs, with genotype G/G at the IGF2 mutation, were progeny-tested. Only two of them displayed significant QTL for fatness traits although four inherited the same paternal and maternal chromosomes, thus exhibiting the same haplotypic contrast in the QTL region. The hypothesis of an interaction with another region in the genome was proposed to explain these discrepancies and after a genome scan, four different regions were retained as potential interacting regions with the SSC2 QTL. A candidate interacting region on SSC13 was confirmed by the analysis of an F2 pedigree, and in the backcross pedigree one haplotype in this region was found to mask the SSC2 QTL effect. Conclusions Assuming the hypothesis of interactions with other chromosomal regions, the QTL could be unambiguously mapped to a 30 cM region delimited by recombination points. The marker-assisted backcrossing design was successfully used to confirm the segregation of a QTL on SSC2 and, because full-sibs that inherited the same alleles from their two parents were analysed, the detection of epistatic interactions could be performed between alleles and not between breeds as usually done with the traditional Line-Cross model. Additional analyses of other recombinant sires should provide more information to further improve the fine-mapping of this locus, and confirm or deny the interaction

  8. Third-order perturbations of a zero-pressure cosmological medium: Pure general relativistic nonlinear effects

    International Nuclear Information System (INIS)

    Hwang, Jai-chan; Noh, Hyerim

    2005-01-01

    We consider a general relativistic zero-pressure irrotational cosmological medium perturbed to the third order. We assume a flat Friedmann background but include the cosmological constant. We ignore the rotational perturbation which decays in expanding phase. In our previous studies we discovered that, to the second-order perturbation, except for the gravitational wave contributions, the relativistic equations coincide exactly with the previously known Newtonian ones. Since the Newtonian second-order equations are fully nonlinear, any nonvanishing third- and higher-order terms in the relativistic analyses are supposed to be pure relativistic corrections. In this work, we derive such correction terms appearing in the third order. Continuing our success in the second-order perturbations, we take the comoving gauge. We discover that the third-order correction terms are of φ v order higher than the second-order terms where φ v is a gauge-invariant combination related to the three-space curvature perturbation in the comoving gauge; compared with the Newtonian potential, we have δΦ∼(3/5)φ v to the linear order. Therefore, the pure general relativistic effects are of φ v order higher than the Newtonian ones. The corrections terms are independent of the horizon scale and depend only on the linear-order gravitational potential (curvature) perturbation strength. From the temperature anisotropy of cosmic microwave background, we have (δT/T)∼(1/3)δΦ∼(1/5)φ v ∼10 -5 . Therefore, our present result reinforces our previous important practical implication that near the current era one can use the large-scale Newtonian numerical simulation more reliably even as the simulation scale approaches near (and goes beyond) the horizon

  9. Protective effects of Andrographis paniculata extract and pure andrographolide against chronic stress-triggered pathologies in rats.

    Science.gov (United States)

    Thakur, Ajit Kumar; Soni, Upendra Kumar; Rai, Geeta; Chatterjee, Shyam Sunder; Kumar, Vikas

    2014-11-01

    This study was designed to experimentally verify the possibility that Andrographis paniculata could be another medicinal herb potentially useful for prevention of diverse spectrums of pathologies commonly associated with chronic unavoidable environmental stress, and whether andrographolide could as well be its quantitatively major bioactive secondary metabolite. Preventive effects of 21 daily oral 50, 100 and 200 mg/kg doses of a therapeutically used extract of the plant (AP) and 30 and 60 mg/kg/day of pure andrographolide were compared in rats subjected to 1-h daily unavoidable foot-shocks. A pharmaceutically well-standardized Withania somnifera (WS) root extract was used as a reference herbal anti-stress agent in all experiments. Effects of the treatments on stress-induced alterations in body weight, gastric ulcer, adrenal and spleen weights, and depressive state and sexual behavior in male rats were quantified. Other parameters quantified were plasma cortisol levels, and expressions of the cytokines TNF-α, IL-10 and IL-1β in blood and brain. All observed stress-induced pathological changes were less pronounced or completely prevented by both AP and pure andrographolide. Even the lowest tested doses of AP (50 mg/kg/day) or of andrographolide (30 mg/kg/day) suppressed almost maximally the blood IL-1β and IL-10 as well as brain TNF-α and IL-10 expressions induced by chronic stress. Qualitatively, the observed activity profiles of both of them were similar to those of WS dose tested. These results reveal that both AP and andrographolide are pharmacologically polyvalent anti-stress agents, and that biological processes regulating corticosterone and cytokine homeostasis are involved in their modes of actions.

  10. Comparison of hydrogen storage properties of pure Mg and milled ...

    Indian Academy of Sciences (India)

    Administrator

    increase the hydriding and dehydriding rates, pure Mg was ground under hydrogen atmosphere (reactive .... Hydrogen storage properties of pure Mg and milled pure Mg. 833. Figure 3. ... elongated and flat shapes via collisions with the steel.

  11. Effect of aspect ratio on natural convective heat transfer adjacent to a vertival isothermal cylinder immersed in pure water

    International Nuclear Information System (INIS)

    Riu, Kap Jong; Eum, Yong Kyoon; Park, Sung Soon

    1990-01-01

    A numerical analysis is performed about the effect of aspect ratio on heat transfer adjacent to a vertical-isothermal cylinder of 0 deg C in pure water. The numerical results for the effect of aspect ratio are presented for ambient water temperature from 1.0 deg C to 15.0 deg C. They include velocity profiles, temperature profiles and mean Nusselt number for the entire flow field. The mean Nusselt numbers of vertival-isothermal cylinder are compared with that of vertival-isothermal plate in increasing aspect ratio of cylinder. Furthermore, the mean Nusselt numbers of unsteady region in the range of 0.084< R<0.328 are obtained by curve-fitting. The natural convection caused by phase change was investigated by experiments when the vertical ice cylinder was immersed in the pure water of which the tempetature range is from 2.0 to 10.0 deg C. Each figure shows a time-exposure photograph of flow occuring at the respective ambient water temperature conditions. As the ambient water temperature is increased from 2.0 to 10.0 deg C, the regimes of upward steady state flows, steady state dual flows and downward steady state flows are observed. Also, the variations of shapes of melting ice cylinder are investigated.(Author)

  12. Effect of Emotion and Personality on Deviation from Purely Rational Decision-Making

    OpenAIRE

    Fiori, M.; Lintas, A.; Mesrobian, S.; Villa, A. E. P.

    2013-01-01

    Human decision-making has consistently demonstrated deviation from "pure" rationality. Emotions are a primary driver of human actions and the current study investigates how perceived emotions and personality traits may affect decision-making during the Ultimatum Game (UG). We manipulated emotions by showing images with emotional connotation while participants decided how to split money with a second player. Event-related potentials (ERPs) from scalp electrodes were recorded during the whole d...

  13. Irradiation in combination of heat treatment of mango puree

    International Nuclear Information System (INIS)

    Noomhorm, A.; Apintanapong, M.

    1996-01-01

    The effect of irradiation with heat combination treatment on the shelf life and quality of mango puree was studied. Thermal inactivation of polyphenol oxidase enzyme at 80 degree C and 15 min. was used as a measure of adequacy of pre-heat treatment. Irradiation of mango puree after heat treatment at dosage of 0, 2, 4, 6 and 8 kGy showed no change in mc, pH, acidity, and TSS but during storage, growth of microorganisms brought changes in these values. Irradiation in combination with low temperature (5 degree C) reduced discoloration and darkening rate during storage. Irradiation dose from 0 to 8 kGy resulted in log linear reductions in microorganism levels but at 6 and 8 kGy, there was no growth of microorganisms. Products irradiated at 8 kGy showed no microorganism growth at both temperatures

  14. Cross-field Mobility in a Pure Electron Plasma

    International Nuclear Information System (INIS)

    Fossum, E.C.; King, L.B.

    2006-01-01

    An electron trapping apparatus was constructed in order to study electron dynamics in the defining electric and magnetic field of a Hall-effect thruster. The approach presented here decouples the cross-field mobility from plasma effects by conducting measurements on a pure electron plasma in a highly controlled environment. Dielectric walls are removed completely eliminating all wall effect; thus, electrons are confined solely by a radial magnetic field and a crossed, independently-controlled, axial electric field that induces the closed-drift azimuthal Hall current. Electron trajectories and cross-field mobility were examined in response to electric and magnetic field strength and background neutral density

  15. Directed Evolution Reveals Unexpected Epistatic Interactions That Alter Metabolic Regulation and Enable Anaerobic Xylose Use by Saccharomyces cerevisiae.

    Directory of Open Access Journals (Sweden)

    Trey K Sato

    2016-10-01

    Full Text Available The inability of native Saccharomyces cerevisiae to convert xylose from plant biomass into biofuels remains a major challenge for the production of renewable bioenergy. Despite extensive knowledge of the regulatory networks controlling carbon metabolism in yeast, little is known about how to reprogram S. cerevisiae to ferment xylose at rates comparable to glucose. Here we combined genome sequencing, proteomic profiling, and metabolomic analyses to identify and characterize the responsible mutations in a series of evolved strains capable of metabolizing xylose aerobically or anaerobically. We report that rapid xylose conversion by engineered and evolved S. cerevisiae strains depends upon epistatic interactions among genes encoding a xylose reductase (GRE3, a component of MAP Kinase (MAPK signaling (HOG1, a regulator of Protein Kinase A (PKA signaling (IRA2, and a scaffolding protein for mitochondrial iron-sulfur (Fe-S cluster biogenesis (ISU1. Interestingly, the mutation in IRA2 only impacted anaerobic xylose consumption and required the loss of ISU1 function, indicating a previously unknown connection between PKA signaling, Fe-S cluster biogenesis, and anaerobiosis. Proteomic and metabolomic comparisons revealed that the xylose-metabolizing mutant strains exhibit altered metabolic pathways relative to the parental strain when grown in xylose. Further analyses revealed that interacting mutations in HOG1 and ISU1 unexpectedly elevated mitochondrial respiratory proteins and enabled rapid aerobic respiration of xylose and other non-fermentable carbon substrates. Our findings suggest a surprising connection between Fe-S cluster biogenesis and signaling that facilitates aerobic respiration and anaerobic fermentation of xylose, underscoring how much remains unknown about the eukaryotic signaling systems that regulate carbon metabolism.

  16. Directed Evolution Reveals Unexpected Epistatic Interactions That Alter Metabolic Regulation and Enable Anaerobic Xylose Use by Saccharomyces cerevisiae.

    Science.gov (United States)

    Sato, Trey K; Tremaine, Mary; Parreiras, Lucas S; Hebert, Alexander S; Myers, Kevin S; Higbee, Alan J; Sardi, Maria; McIlwain, Sean J; Ong, Irene M; Breuer, Rebecca J; Avanasi Narasimhan, Ragothaman; McGee, Mick A; Dickinson, Quinn; La Reau, Alex; Xie, Dan; Tian, Mingyuan; Reed, Jennifer L; Zhang, Yaoping; Coon, Joshua J; Hittinger, Chris Todd; Gasch, Audrey P; Landick, Robert

    2016-10-01

    The inability of native Saccharomyces cerevisiae to convert xylose from plant biomass into biofuels remains a major challenge for the production of renewable bioenergy. Despite extensive knowledge of the regulatory networks controlling carbon metabolism in yeast, little is known about how to reprogram S. cerevisiae to ferment xylose at rates comparable to glucose. Here we combined genome sequencing, proteomic profiling, and metabolomic analyses to identify and characterize the responsible mutations in a series of evolved strains capable of metabolizing xylose aerobically or anaerobically. We report that rapid xylose conversion by engineered and evolved S. cerevisiae strains depends upon epistatic interactions among genes encoding a xylose reductase (GRE3), a component of MAP Kinase (MAPK) signaling (HOG1), a regulator of Protein Kinase A (PKA) signaling (IRA2), and a scaffolding protein for mitochondrial iron-sulfur (Fe-S) cluster biogenesis (ISU1). Interestingly, the mutation in IRA2 only impacted anaerobic xylose consumption and required the loss of ISU1 function, indicating a previously unknown connection between PKA signaling, Fe-S cluster biogenesis, and anaerobiosis. Proteomic and metabolomic comparisons revealed that the xylose-metabolizing mutant strains exhibit altered metabolic pathways relative to the parental strain when grown in xylose. Further analyses revealed that interacting mutations in HOG1 and ISU1 unexpectedly elevated mitochondrial respiratory proteins and enabled rapid aerobic respiration of xylose and other non-fermentable carbon substrates. Our findings suggest a surprising connection between Fe-S cluster biogenesis and signaling that facilitates aerobic respiration and anaerobic fermentation of xylose, underscoring how much remains unknown about the eukaryotic signaling systems that regulate carbon metabolism.

  17. Pure Science and Applied Science

    Directory of Open Access Journals (Sweden)

    Robert J. Aumann

    2011-01-01

    Full Text Available (Excerpt The name of my talk is Pure Science and Applied Science, and the idea I would like to sell to you today is that there is no such thing as “pure” or “applied” science. In other words, there is such a thing as science, but there is no difference between pure and applied science. Science is one entity and cannot be separated into different categories. In order to back that up, I would like to tell you a little story. As an undergraduate, I studied mathematics at City College in New York. At that time, what was called Pure Mathematics was in vogue, and the more prominent mathematicians were a little contemptuous of any kind of application. A very famous, prominent mathematician in the first half of the previous century by the name of G. H. Hardy, who was in a branch of mathematics called number theory, said that the only thing he regretted was that he unwittingly did some important work in mathematical genetics that eventually turned out to have some application. … Such was the atmosphere in the late ’40s of the previous century and, being a young man and impressionable, I was swept up in this atmosphere.

  18. AdS pure spinor superstring in constant backgrounds

    International Nuclear Information System (INIS)

    Chandia, Osvaldo; Bevilaqua, L. Ibiapina; Vallilo, Brenno Carlini

    2014-01-01

    In this paper we study the pure spinor formulation of the superstring in AdS_5×S"5 around point particle solutions of the classical equations of motion. As a particular example we quantize the pure spinor string in the BMN background

  19. Graph Theory to Pure Mathematics: Some Illustrative Examples

    Indian Academy of Sciences (India)

    Graph Theory to Pure Mathematics: Some. Illustrative Examples v Yegnanarayanan is a. Professor of Mathematics at MNM Jain Engineering. College, Chennai. His research interests include graph theory and its applications to both pure maths and theoretical computer science. Keywords. Graph theory, matching theory,.

  20. Nanoporous Au: an unsupported pure gold catalyst?

    Energy Technology Data Exchange (ETDEWEB)

    Wittstock, A; Neumann, B; Schaefer, A; Dumbuya, K; Kuebel, C; Biener, M; Zielasek, V; Steinrueck, H; Gottfried, M; Biener, J; Hamza, A; B?umer, M

    2008-09-04

    The unique properties of gold especially in low temperature CO oxidation have been ascribed to a combination of various effects. In particular, particle sizes below a few nm and specific particle-support interactions have been shown to play important roles. On the contrary, recent reports revealed that monolithic nanoporous gold (npAu) prepared by leaching a less noble metal, such as Ag, out of the corresponding alloy can also exhibit remarkably high catalytic activity for CO oxidation, even though no support is present. Therefore, it was claimed to be a pure and unsupported gold catalyst. We investigated npAu with respect to its morphology, surface composition and catalytic properties. In particular, we studied the reaction kinetics for low temperature CO oxidation in detail taking mass transport limitation due to the porous structure of the material into account. Our results reveal that Ag, even if removed almost completely from the bulk, segregates to the surface resulting in surface concentrations of up to 10 at%. Our data suggest that this Ag plays a significant role in activation of molecular oxygen. Therefore, npAu should be considered as a bimetallic catalyst rather than a pure Au catalyst.

  1. The effect of crystallographic orientation on the active corrosion of pure magnesium

    International Nuclear Information System (INIS)

    Liu Ming; Qiu Dong; Zhao Mingchun; Song, Guangling; Atrens, Andrej

    2008-01-01

    An improved method was used to investigate the influence of crystallographic orientation on the corrosion of pure magnesium in 0.1 N HCl. The corrosion depth and orientation of surface features were mapped against crystallographic orientation (obtained by electron backscatter diffraction) for many off-principal magnesium crystals. The grains near (0 0 0 1) orientation are the most corrosion resistant. Most grains exhibited a striated structure of long and narrow hillocks with a unique direction

  2. Pure motor hemiparesis in a case of vertebrobasilar arterial ectasia

    Energy Technology Data Exchange (ETDEWEB)

    Milandre, L. (Dept. of Neurology, CHU Timone, Marseille (France)); Martini, P. (Dept. of Neuroradiology, CHU Timone, Marseille (France)); Perot, S. (Dept. of Neuroradiology, CHU Timone, Marseille (France)); Mercier, C. (Dept. of Vascular Surgery, CHU Timone, Marseille (France))

    1993-03-01

    A case of pure motor hemiparesis due to a pontine lacunar infarct is reported. Infaction was related to vertebrobasilar ectasia identified on CT, MRI and MR angiography. MR studies provide accurate information on anatomical location, residual lumen, partial thrombosis, mass effect on brain stem and CSF pathways and vascular complications. (orig.)

  3. Expander graphs in pure and applied mathematics

    OpenAIRE

    Lubotzky, Alexander

    2012-01-01

    Expander graphs are highly connected sparse finite graphs. They play an important role in computer science as basic building blocks for network constructions, error correcting codes, algorithms and more. In recent years they have started to play an increasing role also in pure mathematics: number theory, group theory, geometry and more. This expository article describes their constructions and various applications in pure and applied mathematics.

  4. Effects of diuron and carbofuran pesticides in their pure and commercial forms on Paramecium caudatum: The use of protozoan in ecotoxicology.

    Science.gov (United States)

    Mansano, Adrislaine S; Moreira, Raquel A; Pierozzi, Mayara; Oliveira, Thiessa M A; Vieira, Eny M; Rocha, Odete; Regali-Seleghim, Mirna H

    2016-06-01

    Toxic effects of diuron and carbofuran on Paramecium caudatum were evaluated. Acute and chronic tests were conducted with diuron and carbofuran active ingredients and their commercial formulations, Diuron Nortox(®) 500 SC and Furadan(®) 350 SC, respectively. The sensitivity range of P. caudatum to reference substance sodium chloride was established. A preliminary risk assessment of diuron and carbofuran for Brazilian water bodies was performed. The tests indicated that toxicity of pure diuron and its commercial formulation was similar, while the commercial product carbofuran was more toxic than its pure form. In acute tests, readings were carried out at 2, 3, 4 and 6 h and showed an increase of mortality with increasing exposure time. The sensitivity of P. caudatum to NaCl ranged from 3.31 to 4.44 g L(-1), averaging 3.88 g L(-1). For diuron, the 6 h LC50 was 64.6 ± 3.3 mg L(-1) for its pure form and 62.4 ± 2.5 mg L(-1) for its commercial formulation. Carbofuran active ingredient was less toxic than that of diuron, presenting a 6 h LC50 of 142.0 ± 2.4 mg L(-1) for its pure form and 70.4 ± 2.2 mg L(-1) for its commercial product. Chronic tests showed that these pesticides cause significant decrease on population growth, generation number and biomass of P. caudatum. The 24 h IC50 was 7.10 ± 0.58 mg L(-1) for pure diuron, 6.78 ± 0.92 mg L(-1) for commercial diuron, 22.95 ± 3.57 mg L(-1) for pure carbofuran and 4.98 ± 0.62 mg L(-1) for commercial carbofuran. Preliminary risk assessment indicated that diuron and carbofuran present potential ecological risks for Brazilian water bodies. P. caudatum was a suitable and sensitive test organism to evaluate diuron and carbofuran toxicity to freshwater protozooplankton and, taking into account the relevant role of protozoans in aquatic environments, we strongly recommend its inclusion in ecotoxicological studies. Copyright © 2015 Elsevier Ltd. All rights reserved.

  5. Pure odd-order oscillators with constant excitation

    Science.gov (United States)

    Cveticanin, L.

    2011-02-01

    In this paper the excited vibrations of a truly nonlinear oscillator are analyzed. The excitation is assumed to be constant and the nonlinearity is pure (without a linear term). The mathematical model is a second-order nonhomogeneous differential equation with strong nonlinear term. Using the first integral, the exact value of period of vibration i.e., angular frequency of oscillator described with a pure nonlinear differential equation with constant excitation is analytically obtained. The closed form solution has the form of gamma function. The period of vibration depends on the value of excitation and of the order and coefficient of the nonlinear term. For the case of pure odd-order-oscillators the approximate solution of differential equation is obtained in the form of trigonometric function. The solution is based on the exact value of period of vibration. For the case when additional small perturbation of the pure oscillator acts, the so called 'Cveticanin's averaging method' for a truly nonlinear oscillator is applied. Two special cases are considered: one, when the additional term is a function of distance, and the second, when damping acts. To prove the correctness of the method the obtained results are compared with those for the linear oscillator. Example of pure cubic oscillator with constant excitation and linear damping is widely discussed. Comparing the analytically obtained results with exact numerical ones it is concluded that they are in a good agreement. The investigations reported in the paper are of special interest for those who are dealing with the problem of vibration reduction in the oscillator with constant excitation and pure nonlinear restoring force the examples of which can be found in various scientific and engineering systems. For example, such mechanical systems are seats in vehicles, supports for machines, cutting machines with periodical motion of the cutting tools, presses, etc. The examples can be find in electronics

  6. Microstructural and mechanical properties of pure aluminum, 5083 and 7075 alloys joined by friction stir welding

    Energy Technology Data Exchange (ETDEWEB)

    Yilmaz, Selim Sarper [Celal Bayar Univ., Manisa, Muradiye (Turkey)

    2012-07-01

    In this study, microstructural and mechanical properties of pure aluminum, 5083 and 7075 alloys joined by friction stir welding were investigated. Hardness, tensile, bending and impact tests were applied to the welded samples. In addition, optical and SEM tests were carried out. The effects of welding speed on microstructure and mechanical properties were investigated in these materials. Then, the optimal conditions for friction stir welding were determined for pure aluminum, 5083 and 7075 alloys. The maximum hardness was observed for 7075 while the minimum hardness was observed for pure aluminum. (orig.)

  7. AdS pure spinor superstring in constant backgrounds

    Energy Technology Data Exchange (ETDEWEB)

    Chandia, Osvaldo [Departamento de Ciencias, Facultad de Artes Liberales, Universidad Adolfo Ibáñez,Facultad de Ingeniería y Ciencias, Universidad Adolfo Ibáñez,Diagonal Las Torres 2640, Peñalolén, Santiago (Chile); Bevilaqua, L. Ibiapina [Escola de Ciências e Tecnologia, Universidade Federal do Rio Grande do Norte,Caixa Postal 1524, 59072-970, Natal, RN (Brazil); Vallilo, Brenno Carlini [Facultad de Ciencias Exactas, Departamento de Ciencias Físicas, Universidad Andres Bello,Republica 220, Santiago (Chile)

    2014-06-05

    In this paper we study the pure spinor formulation of the superstring in AdS{sub 5}×S{sup 5} around point particle solutions of the classical equations of motion. As a particular example we quantize the pure spinor string in the BMN background.

  8. Multicomponent evaporation model for pure and blended biodiesel droplets in high temperature convective environment

    Energy Technology Data Exchange (ETDEWEB)

    Saha, K.; Abu-Ramadan, E.; Li, X. [Waterloo Univ., ON (Canada). Dept. of Mechanical and Mechatronics Engineering

    2010-07-01

    Renewable energy sources are currently being investigated for their reliability, efficiency, and applicability. Biodiesel is one of the most promising alternatives to conventional diesel fuels in compression-ignition (CI) engines. This paper reported on a study that compared pure biodiesel, pure diesel and blended fuels using a comprehensive multicomponent droplet vaporization model. The model considers the difference in the gas phase diffusivity of diesel and biodiesel vapors. The paper presented the vaporization characteristics of pure diesel, pure biodiesel fuel droplets as well as the effect of mixing them in different proportions (B20 and B50). The model successfully predicted the vaporization history of a multicomponent droplet. The modeling study revealed that biodiesel droplets evaporate at a slower rate than the diesel droplets because of relatively low vapor pressure. As such, the blending of diesel fuel with small proportions of biodiesel will result in an increase in the evaporation time of diesel fuel to some extent. 31 refs., 6 figs.

  9. Engineering arbitrary pure and mixed quantum states

    International Nuclear Information System (INIS)

    Pechen, Alexander

    2011-01-01

    Controlled manipulation by atomic- and molecular-scale quantum systems has attracted a lot of research attention in recent years. A fundamental problem is to provide deterministic methods for controlled engineering of arbitrary quantum states. This work proposes a deterministic method for engineering arbitrary pure and mixed states of a wide class of quantum systems. The method exploits a special combination of incoherent and coherent controls (incoherent and coherent radiation) and has two properties which are specifically important for manipulating by quantum systems: it realizes the strongest possible degree of their state control, complete density matrix controllability, meaning the ability to steer arbitrary pure and mixed initial states into any desired pure or mixed final state, and it is all-to-one, such that each particular control transfers all initial system states into one target state.

  10. Effect of pectinase treatment on extraction of antioxidant phenols from pomace, for the production of puree-enriched cloudy apple juices.

    Science.gov (United States)

    Oszmiański, Jan; Wojdyło, Aneta; Kolniak, Joanna

    2011-07-15

    Effects of pomace maceration on yield, turbidity, cloud stability, composition of phenolics, antioxidant activity and colour properties were studied, to evaluate the potential applicability of enzyme preparations in puree-enriched cloudy apple juice production. The yield of mixed juice and puree from pomace obtained in the enzymatic processing of apple ranged from 92.3% to 95.3%, significantly higher than the yield from the control without enzymatic pomace treatment (81.8%). Higher turbidity was obtained upon pomace treatment with Pectinex XXL and Pectinex Ultra SPL enzymes. The total content of phenolic compounds in apple pomace was higher than in raw juices (1520mg/kg and 441mg/L, respectively). The total polyphenol yields were higher in juices treated with Pectinex AFP L-4, Pectinex Yield Mash and Pectinex XXL, as compared to the control treatment. During 6months of storage, a significant change was observed in the content of polyphenols, especially in procyanidin fractions. Crown Copyright © 2011. Published by Elsevier Ltd. All rights reserved.

  11. Grain fragmentation in ultrasonic-assisted TIG weld of pure aluminum.

    Science.gov (United States)

    Chen, Qihao; Lin, Sanbao; Yang, Chunli; Fan, Chenglei; Ge, Hongliang

    2017-11-01

    Under the action of acoustic waves during an ultrasonic-assisted tungsten inert gas (TIG) welding process, a grain of a TIG weld of aluminum alloy is refined by nucleation and grain fragmentation. Herein, effects of ultrasound on grain fragmentation in the TIG weld of aluminum alloy are investigated via systematic welding experiments of pure aluminum. First, experiments involving continuous and fixed-position welding are performed, which demonstrate that ultrasound can break the grain of the TIG weld of pure aluminum. The microstructural characteristics of an ultrasonic-assisted TIG weld fabricated by fixed-position welding are analyzed. The microstructure is found to transform from plane crystal, columnar crystal, and uniform equiaxed crystal into plane crystal, deformed columnar crystal, and nonuniform equiaxed crystal after application of ultrasound. Second, factors influencing ultrasonic grain fragmentation are investigated. The ultrasonic amplitude and welding current are found to have a considerable effect on grain fragmentation. The degree of fragmentation first increases and then decreases with an increase in ultrasonic amplitude, and it increases with an increase in welding current. Measurement results of the vibration of the weld pool show that the degree of grain fragmentation is related to the intensity of acoustic nonlinearity in the weld pool. The greater the intensity of acoustic nonlinearity, the greater is the degree of grain fragmentation. Finally, the mechanism of ultrasonic grain fragmentation in the TIG weld of pure aluminum is discussed. A finite element simulation is used to simulate the acoustic pressure and flow in the weld pool. The acoustic pressure in the weld pool exceeds the cavitation threshold, and cavitation bubbles are generated. The flow velocity in the weld pool does not change noticeably after application of ultrasound. It is concluded that the high-pressure conditions induced during the occurrence of cavitation, lead to grain

  12. Effect Of Natural Convection On Directional Solidification Of Pure Metal

    Directory of Open Access Journals (Sweden)

    Skrzypczak T.

    2015-06-01

    Full Text Available The paper is focused on the modeling of the directional solidification process of pure metal. During the process the solidification front is sharp in the shape of the surface separating liquid from solid in three dimensional space or a curve in 2D. The position and shape of the solid-liquid interface change according to time. The local velocity of the interface depends on the values of heat fluxes on the solid and liquid sides. Sharp interface solidification belongs to the phase transition problems which occur due to temperature changes, pressure, etc. Transition from one state to another is discontinuous from the mathematical point of view. Such process can be identified during water freezing, evaporation, melting and solidification of metals and alloys, etc.

  13. Complex windmill transformation producing new purely magnetic fluids

    International Nuclear Information System (INIS)

    Lozanovski, C; Wylleman, L

    2011-01-01

    Minimal complex windmill transformations of G 2 IB(ii) spacetimes (admitting a two-dimensional Abelian group of motions of the so-called Wainwright B(ii) class) are defined and the compatibility with a purely magnetic Weyl tensor is investigated. It is shown that the transformed spacetimes cannot be perfect fluids or purely magnetic Einstein spaces. We then determine which purely magnetic perfect fluids (PMpfs) can be windmill-transformed into purely magnetic anisotropic fluids (PMafs). Assuming separation of variables, complete integration produces two, algebraically general, G 2 I-B(ii) PMpfs: a solution with zero 4-acceleration vector and spatial energy-density gradient, previously found by the authors, and a new solution in terms of Kummer's functions, where these vectors are aligned and non-zero. The associated windmill PMafs are rotating but non-expanding. Finally, an attempt to relate the spacetimes to each other by a simple procedure leads to a G 2 I-B(ii) one-parameter PMaf generalization of the previously found metric.

  14. Metastable growth of pure wurtzite InGaAs microstructures.

    Science.gov (United States)

    Ng, Kar Wei; Ko, Wai Son; Lu, Fanglu; Chang-Hasnain, Connie J

    2014-08-13

    III-V compound semiconductors can exist in two major crystal phases, namely, zincblende (ZB) and wurtzite (WZ). While ZB is thermodynamically favorable in conventional III-V epitaxy, the pure WZ phase can be stable in nanowires with diameters smaller than certain critical values. However, thin nanowires are more vulnerable to surface recombination, and this can ultimately limit their performances as practical devices. In this work, we study a metastable growth mechanism that can yield purely WZ-phased InGaAs microstructures on silicon. InGaAs nucleates as sharp nanoneedles and expand along both axial and radial directions simultaneously in a core-shell fashion. While the base can scale from tens of nanometers to over a micron, the tip can remain sharp over the entire growth. The sharpness maintains a high local surface-to-volume ratio, favoring hexagonal lattice to grow axially. These unique features lead to the formation of microsized pure WZ InGaAs structures on silicon. To verify that the WZ microstructures are truly metastable, we demonstrate, for the first time, the in situ transformation from WZ to the energy-favorable ZB phase inside a transmission electron microscope. This unconventional core-shell growth mechanism can potentially be applied to other III-V materials systems, enabling the effective utilization of the extraordinary properties of the metastable wurtzite crystals.

  15. Purely leptonic currents

    International Nuclear Information System (INIS)

    Gourdin, M.

    1976-01-01

    In most gauge theories weak neutral currents appear as a natural consequence of the models, but the specific properties are not predicted in a general way. In purely leptonic interactions the structure of these currents can be tested without making assumptions about the weak couplings of the hadrons. The influence of neutral currents appearing in the process e + e - → μ + μ - can be measured using the polarization of the outgoing myons. (BJ) [de

  16. Language as Pure Potential

    Science.gov (United States)

    Park, Joseph Sung-Yul

    2016-01-01

    Language occupies a crucial position in neoliberalism, due to the reimagination of language as commodified skill. This paper studies the role of language ideology in this transformation by identifying a particular ideology that facilitates this process, namely the ideology which views language as pure potential. Neoliberalism treats language as a…

  17. Dahlbeck and Pure Ontology

    Science.gov (United States)

    Mackenzie, Jim

    2016-01-01

    This article responds to Johan Dahlbeck's "Towards a pure ontology: Children's bodies and morality" ["Educational Philosophy and Theory," vol. 46 (1), 2014, pp. 8-23 (EJ1026561)]. His arguments from Nietzsche and Spinoza do not carry the weight he supposes, and the conclusions he draws from them about pedagogy would be…

  18. TVT-O for the treatment of pure urodynamic stress incontinence: efficacy, adverse effects, and prognostic factors at 5-year follow-up.

    Science.gov (United States)

    Serati, Maurizio; Bauer, Ricarda; Cornu, Jean Nicolas; Cattoni, Elena; Braga, Andrea; Siesto, Gabriele; Lizée, Daphné; Haab, François; Torella, Marco; Salvatore, Stefano

    2013-05-01

    Inside-out tension-free vaginal transobturator tape (TVT-O) is currently one of the most effective and popular procedures for the surgical treatment of female stress urinary incontinence (SUI), but data reporting long-term outcomes are scarce. To evaluate the efficacy and safety of TVT-O 5-yr implantation for management of pure SUI in women. A prospective observational study was conducted in four tertiary reference centers. Consecutive women presenting with urodynamically proven, pure SUI treated by TVT-O were included. Patients with mixed incontinence and/or anatomic evidence of pelvic organ prolapse were excluded. TVT-O implantation without any associated procedure. Data regarding subjective outcomes (International Consultation on Incontinence-Short Form [ICIQ-SF], Patient Global Impression of Improvement, patient satisfaction scores), objective cure (stress test) rates, and adverse events were collected during follow-up. Multivariable analyses were performed to investigate outcomes. Of the 191 women included, 21 (11.0%) had previously undergone a failed anti-incontinence surgical procedure. Six (3.1%) patients were lost to follow-up. The 5-yr subjective and objective cure rates were 90.3% and 90.8%, respectively. De novo overactive bladder (OAB) was reported by 24.3% of patients at 5-yr follow-up. Median ICIQ-SF score significantly improved from 17 (interquartile range [IQR]:16-17) preoperatively to 0 (IQR: 0-2) (pTVT-O implantation is a highly effective option for the treatment of women with pure SUI, showing a very high cure rate and a low incidence of complications after 5-yr follow-up. Copyright © 2012 European Association of Urology. Published by Elsevier B.V. All rights reserved.

  19. Chapter 12. Pure Tap Water Hydraulic Systems and Applications

    DEFF Research Database (Denmark)

    Conrad, Finn; Adelstorp, Anders

    1997-01-01

    Presentation of developed a modern pure tap water hydraulic components (Nessie), systems and industrial applications.......Presentation of developed a modern pure tap water hydraulic components (Nessie), systems and industrial applications....

  20. A/α-specific effect of the mms3 mutation on ultraviolet mutagenesis in Saccharomyces cerevisiae

    International Nuclear Information System (INIS)

    Martin, P.; Prakash, L.; Prakash, S.

    1981-01-01

    A new gene involved in error-prone repair of ultraviolet (uv) damage has been identified in Saccharomyces cerevisiae by the mms3-1 mutation. Uv-induced reversion is reduced in diploids that are homozygous for mms3-1, only if they are also heterozygous (MATa/MATα) at the mating type locus. The mms3-1 mutation has no effect on uv-induced reversion either in haploids or MATa/MATα or MATα/MATα diploids. The mutation confers sensitivity to uv and methyl methane sulfonate in both haploids and diploids. Even though mutation induction by uv is restored to wild-type levels in MATa/MATa mms3-1/mms3-1 or MATα/MATα mms3-1/mms3-1 diploids, such strains still retain sensitivity to the lethal effects of uv. Survival after uv irradiation in mms3-1 rad double mutant combinations indicates that mms3-1 is epistatic to rad6-1 whereas non-epistatic interactions are observed with rad3 and rad52 mutants. When present in the homozygous state in MATa/MATα his1-1/his1-315 heteroallelic diploids, mms3-1 was found to lower uv-induced mitotic recombination

  1. Literature Survey on the Effects of Pure Carbon Dioxide on Health, Comfort and Performance

    DEFF Research Database (Denmark)

    Zhang, Xiaojing; Wargocki, Pawel; Lian, Zhiwei

    2014-01-01

    permissible occupational exposure level to CO2 is set at 5,000 ppm (ACGIH, 2011). Although in many studies CO2 has been related with health symptoms, comfort and performance of office work and schoolwork, it in itself has traditionally been assumed innocuous at the typical levels indoors; in these studies, CO......2 was merely a proxy for elevated exposure levels to air pollutants, and an indicator of inadequate outdoor air ventilation and poor indoor air quality. Two recent experiments suggest however that the exposure to pure CO2 at the levels typically occurring indoors and lower than the levels prescribed...... as permissible by the occupational standards can have negative effects on some aspects of human performance, in particular on tasks requiring concentration (Kajtar et al., 2006) and on tasks, in which decision should be taken (Satish et al., 2012). The present paper reports the results of the literature survey...

  2. Effect of colloid (Androcoll-Bear, Percoll, and PureSperm) selection on the freezability of brown bear (Ursus arctos) sperm.

    Science.gov (United States)

    Álvarez-Rodríguez, M; Álvarez, M; Anel-López, L; López-Urueña, E; Manrique, P; Borragán, S; Morrell, J M; de Paz, P; Anel, L

    2016-04-01

    The development of a species-specific conservation protocol that involves artificial insemination with frozen semen needs to validate an effective methodology for freezing semen. Colloid centrifugation has been suggested and widely applied as an effective tool for selecting animal spermatozoa for artificial breeding. The objective of the present study was to compare different methods of centrifugation, single layer using Androcoll-Bear and Percoll and double layer using PureSperm 100 (in two different discontinuous gradients 40%-80% and 45%-90%), for the selection of fresh brown bear sperm samples. In the before freezing group, all selected samples showed a higher progressive motility and viability (except Percoll for motility 43.0 ± 5.3 [P Bear in number of damaged acrosomes, different relative to the control (control, 5.3 ± 0.6; PureSperm 80, 2.0 ± 0.3; Androcoll, 2.1 ± 0.9 [P Bear constitutes a useful tool for handling of brown bear ejaculates owing to its simple handling and procedure with a reliable sperm selection and freezability. This colloid yielded an improvement in several sperm parameters in brown bear frozen-thawed semen; the selected spermatozoa of fresh samples with this colloid showed a better resistance to freezing compared with the control sample not only for motility but also for viability. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. Production of pure metals

    Science.gov (United States)

    Philipp, W. H.; Marsik, S. J.; May, C. E. (Inventor)

    1974-01-01

    A process for depositing elements by irradiating liquids is reported. Ultra pure elements are precipitated from aqueous solutions or suspensions of compounds. A solution of a salt of a metal to be prepared is irradiated, and the insoluble reaction product settles out. Some chemical compounds may also be prepared in this manner.

  4. Capturing pair-wise epistatic effects associated with three agronomic traits in barley.

    Science.gov (United States)

    Xu, Yi; Wu, Yajun; Wu, Jixiang

    2018-04-01

    Genetic association mapping has been widely applied to determine genetic markers favorably associated with a trait of interest and provide information for marker-assisted selection. Many association mapping studies commonly focus on main effects due to intolerable computing intensity. This study aims to select several sets of DNA markers with potential epistasis to maximize genetic variations of some key agronomic traits in barley. By doing so, we integrated a MDR (multifactor dimensionality reduction) method with a forward variable selection approach. This integrated approach was used to determine single nucleotide polymorphism pairs with epistasis effects associated with three agronomic traits: heading date, plant height, and grain yield in barley from the barley Coordinated Agricultural Project. Our results showed that four, seven, and five SNP pairs accounted for 51.06, 45.66 and 40.42% for heading date, plant height, and grain yield, respectively with epistasis being considered, while corresponding contributions to these three traits were 45.32, 31.39, 31.31%, respectively without epistasis being included. The results suggested that epistasis model was more effective than non-epistasis model in this study and can be more preferred for other applications.

  5. Nigeria Journal of Pure and Applied Physics: Journal Sponsorship

    African Journals Online (AJOL)

    Nigeria Journal of Pure and Applied Physics: Journal Sponsorship. Journal Home > About the Journal > Nigeria Journal of Pure and Applied Physics: Journal Sponsorship. Log in or Register to get access to full text downloads.

  6. Nigeria Journal of Pure and Applied Physics: Site Map

    African Journals Online (AJOL)

    Nigeria Journal of Pure and Applied Physics: Site Map. Journal Home > About the Journal > Nigeria Journal of Pure and Applied Physics: Site Map. Log in or Register to get access to full text downloads.

  7. Implantation driven permeation behavior of deuterium through pure tungsten

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, Hirofumi E-mail: nakamura@tpl.tokai.jaeri.go.jp; Hayashi, Takumi; Nishi, Masataka; Arita, Makoto; Okuno, Kenji

    2001-09-01

    Implantation driven permeation behavior of deuterium through pure tungsten has been investigated to estimate the amount of tritium permeation through its barrier in a thermo-nuclear fusion device. The permeation experiments were performed on pure tungsten foil of 25 {mu}m thickness under conditions of incident flux of 1.9x10{sup 18}-1.1x10{sup 19} D{sup +}/m{sup 2}s, incident ion energy of 200-2000 eV, and specimen temperature of 512-660 K. As a result of this steady-state permeation experiment, the rate-determining process of deuterium permeation was found to be controlled by diffusion at both implanted and permeated sides. On the other hand, transient permeation was strongly affected by trap effect in the specimen. Simulation analysis using TMAP code on transient permeation behavior indicates the existence of a trap site with a trap energy of nearly 1eV and with a trap density of over several ten's ppm in tungsten.

  8. Implantation driven permeation behavior of deuterium through pure tungsten

    International Nuclear Information System (INIS)

    Nakamura, Hirofumi; Hayashi, Takumi; Nishi, Masataka; Arita, Makoto; Okuno, Kenji

    2001-01-01

    Implantation driven permeation behavior of deuterium through pure tungsten has been investigated to estimate the amount of tritium permeation through its barrier in a thermo-nuclear fusion device. The permeation experiments were performed on pure tungsten foil of 25 μm thickness under conditions of incident flux of 1.9x10 18 -1.1x10 19 D + /m 2 s, incident ion energy of 200-2000 eV, and specimen temperature of 512-660 K. As a result of this steady-state permeation experiment, the rate-determining process of deuterium permeation was found to be controlled by diffusion at both implanted and permeated sides. On the other hand, transient permeation was strongly affected by trap effect in the specimen. Simulation analysis using TMAP code on transient permeation behavior indicates the existence of a trap site with a trap energy of nearly 1eV and with a trap density of over several ten's ppm in tungsten

  9. Structural properties of pure and Fe-doped Yb films prepared by vapor condensation

    Energy Technology Data Exchange (ETDEWEB)

    Rojas-Ayala, C., E-mail: chachi@cbpf.br [Centro Brasileiro de Pesquisas Físicas, Rio de Janeiro 22290-180, RJ (Brazil); Facultad de Ciencias Físicas, Universidad Nacional Mayor de San Marcos, Lima, P.O.B. 14-149, Lima 14 (Peru); Passamani, E.C. [Departamento de Física, Universidade Federal do Espírito Santo, Vitória 29075-910, ES (Brazil); Suguihiro, N.M. [Centro Brasileiro de Pesquisas Físicas, Rio de Janeiro 22290-180, RJ (Brazil); Litterst, F.J. [Centro Brasileiro de Pesquisas Físicas, Rio de Janeiro 22290-180, RJ (Brazil); Institut für Physik der Kondensierten Materie, Technische Universität Braunschweig, 38106 Braunschweig (Germany); Baggio Saitovitch, E. [Centro Brasileiro de Pesquisas Físicas, Rio de Janeiro 22290-180, RJ (Brazil)

    2014-10-15

    Ytterbium and iron-doped ytterbium films were prepared by vapor quenching on Kapton substrates at room temperature. Structural characterization was performed by X-ray diffraction and transmission electron microscopy. The aim was to study the microstructure of pure and iron-doped films and thereby to understand the effects induced by iron incorporation. A coexistence of face centered cubic and hexagonal close packed-like structures was observed, the cubic-type structure being the dominant contribution. There is an apparent thickness dependence of the cubic/hexagonal relative ratios in the case of pure ytterbium. Iron-clusters induce a crystalline texture effect, but do not influence the cubic/hexagonal volume fraction. A schematic model is proposed for the microstructure of un-doped and iron-doped films including the cubic- and hexagonal-like structures, as well as the iron distribution in the ytterbium matrix. - Highlights: • Pure and Fe-doped Yb films have been prepared by vapor condensation. • Coexistence of fcc- and hcp-type structures was observed. • No oxide phases have been detected. • Fe-clustering does not affect the fcc/hcp ratio, but favors a crystalline texture. • A schematic model is proposed to describe microscopically the microstructure.

  10. Consumption of both low and high (-)-epicatechin apple puree attenuates platelet reactivity and increases plasma concentrations of nitric oxide metabolites: A randomized controlled trial

    NARCIS (Netherlands)

    Gasper, A.; Hollands, W.; Casgrain, A.; Saha, S.; Teucher, B.; Dainty, J.R.; Venema, D.P.; Hollman, P.C.H.

    2014-01-01

    We hypothesised that consumption of flavanol-containing apple puree would modulate platelet activity and increase nitric oxide metabolite status, and that high flavanol apple puree would exert a greater effect than low flavanol apple puree. 25 subjects consumed 230 g of apple puree containing 25 and

  11. Measurements of electron drift velocity in pure isobutane

    Energy Technology Data Exchange (ETDEWEB)

    Vivaldini, Tulio C.; Lima, Iara B.; Goncalves, Josemary A.C.; Botelho, Suzana; Tobias, Carmen C.B., E-mail: ccbueno@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Ridenti, Marco A.; Pascholati, Paulo R. [Universidade de Sao Paulo (USP), SP (Brazil). Inst. de Fisica. Lab. do Acelerador Linear; Fonte, Paulo; Mangiarotti, Alessio [Universidade de Coimbra (Portugal). Dept de Fisica. Lab. de Instrumentacao e Fisica Experimental de Particulas

    2009-07-01

    In this work we report on preliminary results related to the dependence of the electron drift velocity for pure isobutane as a function of reduced electric field (E/N) in the range from 100 Td up to 216 Td. The measurements of electron drift velocity were based on the Pulsed Townsend technique. In order to validate the technique and analyzing non-uniformity effects, results for nitrogen are also presented and compared with a numerical simulation of the Bolsig+ code. (author)

  12. Measurements of electron drift velocity in pure isobutane

    International Nuclear Information System (INIS)

    Vivaldini, Tulio C.; Lima, Iara B.; Goncalves, Josemary A.C.; Botelho, Suzana; Tobias, Carmen C.B.; Ridenti, Marco A.; Pascholati, Paulo R.; Fonte, Paulo; Mangiarotti, Alessio

    2009-01-01

    In this work we report on preliminary results related to the dependence of the electron drift velocity for pure isobutane as a function of reduced electric field (E/N) in the range from 100 Td up to 216 Td. The measurements of electron drift velocity were based on the Pulsed Townsend technique. In order to validate the technique and analyzing non-uniformity effects, results for nitrogen are also presented and compared with a numerical simulation of the Bolsig+ code. (author)

  13. Black hole attractors and pure spinors

    International Nuclear Information System (INIS)

    Hsu, Jonathan P.; Maloney, Alexander; Tomasiello, Alessandro

    2006-01-01

    We construct black hole attractor solutions for a wide class of N = 2 compactifications. The analysis is carried out in ten dimensions and makes crucial use of pure spinor techniques. This formalism can accommodate non-Kaehler manifolds as well as compactifications with flux, in addition to the usual Calabi-Yau case. At the attractor point, the charges fix the moduli according to Σf k = Im(CΦ), where Φ is a pure spinor of odd (even) chirality in IIB (A). For IIB on a Calabi-Yau, Φ = Ω and the equation reduces to the usual one. Methods in generalized complex geometry can be used to study solutions to the attractor equation

  14. Black Hole Attractors and Pure Spinors

    International Nuclear Information System (INIS)

    Hsu, Jonathan P.; Maloney, Alexander; Tomasiello, Alessandro

    2006-01-01

    We construct black hole attractor solutions for a wide class of N = 2 compactifications. The analysis is carried out in ten dimensions and makes crucial use of pure spinor techniques. This formalism can accommodate non-Kaehler manifolds as well as compactifications with flux, in addition to the usual Calabi-Yau case. At the attractor point, the charges fix the moduli according to Σf k = Im(CΦ), where Φ is a pure spinor of odd (even) chirality in IIB (A). For IIB on a Calabi-Yau, Φ = (Omega) and the equation reduces to the usual one. Methods in generalized complex geometry can be used to study solutions to the attractor equation

  15. de Haas-van Alphen effect investigations of the electronic structure of pure and aluminum-doped MgB2

    International Nuclear Information System (INIS)

    Carrington, A.; Yelland, E.A.; Fletcher, J.D.; Cooper, J.R.

    2007-01-01

    Our understanding of the superconducting properties of MgB 2 is strongly linked to our knowledge of its electronic structure. In this paper we review experimental measurements of the Fermi surface parameters of pure and Al-doped MgB 2 using the de Haas-van Alphen (dHvA) effect. In general, the measurements are in excellent agreement with the theoretical predictions of the electronic structure, including the strength of the electron-phonon coupling on each Fermi surface sheet. For the Al doped samples, we are able to measure how the band structure changes with doping. These results are in excellent agreement with calculations based on the virtual crystal approximation. We also review work on the dHvA effect in the superconducting state

  16. Effect of Different Welding Processes on Electrochemical and Corrosion Behavior of Pure Nickel in 1 M NaCl Solution

    Directory of Open Access Journals (Sweden)

    Xijing Wang

    2017-11-01

    Full Text Available A plasma arc welding (PAW-tungsten inert gas (TIG hybrid welding process is proposed to weld pure nickel. In PAW-TIG welding, the arc of the PAW was first to be ignited, then TIG was ignited, while in PAW welding, only the PAW arc was launched. This paper investigated the effect of different welding processes on electrochemical and corrosion performance of between a pure nickel joint and a base metal in an aerated 1 M NaCl solution, respectively. The average grain size of the joint fabricated by PAW welding (denoted as JP joint is 463.57 μm, the joint fabricated by PAW-TIG welding(denoted as JP-T joint is 547.32 μm, and the base metal (BM is 47.32 μm. In this work, the passivity behaviors of samples were characterized for two welding processes by electrochemical impedance spectroscopy (EIS, open circuit potential versus immersion time (OCP-t, and the potentiodynamic polarization plots. EIS spectra, attained with different immersion times, were analyzed and fitted by an equivalent electrical circuit. Photomicrographs of BM, JP, and JP-T were also taken with a scanning electron microscope (SEM to reveal the morphological structure of the pit surfaces. Electrochemical tests show that the sequence of the corrosion resistance is BM > JP > JP-T. The size and quantity of the hemispherical corrosion pits of all samples are different. The corrosion morphology observations found a consistency with the consequence of the electrochemical measurements. The results show that an increase of the grain dimensions due to different heat treatments decreased the pure nickel stability to pitting corrosion.

  17. Pure Air`s Bailly scrubber: A four-year retrospective

    Energy Technology Data Exchange (ETDEWEB)

    Manavi, G.B.; Vymazal, D.C. [Pure Air, Allentown, PA (United States); Sarkus, T.A. [Dept. of Energy, Pittsburgh, PA (United States)

    1997-12-31

    Pure Air`s Advanced Flue Gas Desulfurization (AFGD) Clean Coal Project has completed four highly successful years of operation at NIPSCO`s Bailly Station. As part of their program, Pure Air has concluded a six-part study of system performance. This paper summarizes the results of the demonstration program, including AFGD performance on coals ranging from 2.0--2.4% sulfur. The paper highlights novel aspects of the Bailly facility, including pulverized limestone injection, air rotary sparger for oxidation, wastewater evaporation system and the production of PowerChip{reg_sign} gypsum. Operations and maintenance which have led to the facility`s notable 99.47% availability record are also discussed. A project company, Pure Air on the Lake Limited Partnership, owns the AFGD facility. Pure Air was the turn key contractor and Air Products and Chemicals, Inc. is the operator of the AFGD system.

  18. Shunting arc plasma source for pure carbon ion beam

    Energy Technology Data Exchange (ETDEWEB)

    Koguchi, H.; Sakakita, H.; Kiyama, S.; Shimada, T.; Sato, Y.; Hirano, Y. [Energy Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Umezono, Tsukuba, Ibaraki 305-8568 (Japan)

    2012-02-15

    A plasma source is developed using a coaxial shunting arc plasma gun to extract a pure carbon ion beam. The pure carbon ion beam is a new type of deposition system for diamond and other carbon materials. Our plasma device generates pure carbon plasma from solid-state carbon material without using a hydrocarbon gas such as methane gas, and the plasma does not contain any hydrogen. The ion saturation current of the discharge measured by a double probe is about 0.2 mA/mm{sup 2} at the peak of the pulse.

  19. Shunting arc plasma source for pure carbon ion beam.

    Science.gov (United States)

    Koguchi, H; Sakakita, H; Kiyama, S; Shimada, T; Sato, Y; Hirano, Y

    2012-02-01

    A plasma source is developed using a coaxial shunting arc plasma gun to extract a pure carbon ion beam. The pure carbon ion beam is a new type of deposition system for diamond and other carbon materials. Our plasma device generates pure carbon plasma from solid-state carbon material without using a hydrocarbon gas such as methane gas, and the plasma does not contain any hydrogen. The ion saturation current of the discharge measured by a double probe is about 0.2 mA∕mm(2) at the peak of the pulse.

  20. Apple fruit acidity is genetically diversified by natural variations in three hierarchical epistatic genes MdSAUR37, MdPP2CH and MdALMTII.

    Science.gov (United States)

    Jia, Dongjie; Shen, Fei; Wang, Yi; Wu, Ting; Xu, Xuefeng; Zhang, Xinzhong; Han, Zhenhai

    2018-05-11

    Many efforts have been made to map quantitative trait loci (QTLs) to facilitate practical marker-assisted selection (MAS) in plants. In the present study, we identified four genome-wide major QTLs responsible for apple fruit acidity by MapQTL and BSA-seq analyses using two independent pedigree-based populations. Candidate genes were screened in major QTL regions, and three functional gene markers, including a non-synonymous A/G single nucleotide polymorphism (SNP) in the coding region of MdPP2CH, a 36-bp insertion in the promoter of MdSAUR37, and a previously reported SNP in MdALMTII, were validated to influence the malate content of apple fruits. In addition, MdPP2CH inactivated three vacuolar H + -ATPases (MdVHA-A3, MdVHA-B2 and MdVHA-D2) and one aluminium-activated malate transporter (MdALMTII) via dephosphorylation and negatively influenced fruit malate accumulation. The dephosphotase activity of MdPP2CH was suppressed by MdSAUR37, which implied a higher hierarchy of genetic interaction. Therefore, the MdSAUR37/MdPP2CH/MdALMTII chain cascaded hierarchical epistatic genetic effects to precisely determine apple fruit malate content. An A/G SNP (-1010) on MdMYB44 promoter region from a major QTL (qtl08.1) was closely associated with fruit malate content. The predicted phenotype values (PPVs) were estimated using the tentative genotype values of the gene markers, and the PPVs were significantly correlated with the observed phenotype values. Our findings provide an insight into plant genome-based selection in apples and will aid in conducting research to understand the physiological fundamentals of quantitative genetics. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  1. Evolution of genetic architecture under directional selection.

    Science.gov (United States)

    Hansen, Thomas F; Alvarez-Castro, José M; Carter, Ashley J R; Hermisson, Joachim; Wagner, Günter P

    2006-08-01

    We investigate the multilinear epistatic model under mutation-limited directional selection. We confirm previous results that only directional epistasis, in which genes on average reinforce or diminish each other's effects, contribute to the initial evolution of mutational effects. Thus, either canalization or decanalization can occur under directional selection, depending on whether positive or negative epistasis is prevalent. We then focus on the evolution of the epistatic coefficients themselves. In the absence of higher-order epistasis, positive pairwise epistasis will tend to weaken relative to additive effects, while negative pairwise epistasis will tend to become strengthened. Positive third-order epistasis will counteract these effects, while negative third-order epistasis will reinforce them. More generally, gene interactions of all orders have an inherent tendency for negative changes under directional selection, which can only be modified by higher-order directional epistasis. We identify three types of nonadditive quasi-equilibrium architectures that, although not strictly stable, can be maintained for an extended time: (1) nondirectional epistatic architectures; (2) canalized architectures with strong epistasis; and (3) near-additive architectures in which additive effects keep increasing relative to epistasis.

  2. Pure Electric and Pure Magnetic Resonances in Near-Infrared Metal Double-Triangle Metamaterial Arrays

    International Nuclear Information System (INIS)

    Cao Zhi-Shen; Pan Jian; Chen Zhuo; Zhan Peng; Min Nai-Ben; Wang Zhen-Lin

    2011-01-01

    We experimentally and numerically investigate the optical properties of metamaterial arrays composed of double partially-overlapped metallic nanotriangles fabricated by an angle-resolved nanosphere lithography. We demonstrate that each double-triangle can be viewed as an artificial magnetic element analogous to the conventional metal split-ring-resonator. It is shown that under normal-incidence conditions, individual double-triangle can exhibit a strong local magnetic resonance, but the collective response of the metamaterial arrays is purely electric because magnetic resonances of the two double-triangles in a unit cell having opposite openings are out of phase. For oblique incidences the metamaterial arrays are shown to support a pure magnetic response at the same frequency band. Therefore, switchable electric and magnetic resonances are achieved in double-triangle arrays. Moreover, both the electric and magnetic resonances are shown to allow for a tunability over a large spectral range down to near-infrared. (condensed matter: electronic structure, electrical, magnetic, and optical properties)

  3. Synthesis of diastereomerically and enantiomerically pure 2,3-disubstituted tetrahydrofurans using a sulfoxonium ylide.

    Science.gov (United States)

    Schomaker, Jennifer M; Pulgam, Veera Reddy; Borhan, Babak

    2004-10-27

    Nucleophilic substitution reactions of 2,3-epoxy alcohols, easily prepared via Sharpless asymmetric epoxidation chemistry, offer access to a wide variety of enantiomerically pure compounds. In this communication, we describe the use of a Payne rearrangement to control regioselectivity in the ring-opening of a series of 2,3-epoxy alcohols with dimethylsulfoxonium methylide to yield diastereomerically and/or enantiomerically pure disubstituted tetrahydrofuran rings. The factors influencing the success and substitution pattern of the THF ring products are discussed, including steric, electronic, and solvent effects.

  4. Superposing pure quantum states with partial prior information

    Science.gov (United States)

    Dogra, Shruti; Thomas, George; Ghosh, Sibasish; Suter, Dieter

    2018-05-01

    The principle of superposition is an intriguing feature of quantum mechanics, which is regularly exploited in many different circumstances. A recent work [M. Oszmaniec et al., Phys. Rev. Lett. 116, 110403 (2016), 10.1103/PhysRevLett.116.110403] shows that the fundamentals of quantum mechanics restrict the process of superimposing two unknown pure states, even though it is possible to superimpose two quantum states with partial prior knowledge. The prior knowledge imposes geometrical constraints on the choice of input states. We discuss an experimentally feasible protocol to superimpose multiple pure states of a d -dimensional quantum system and carry out an explicit experimental realization for two single-qubit pure states with partial prior information on a two-qubit NMR quantum information processor.

  5. A purely Lagrangian method for the numerical integration of Fokker-Planck equations

    International Nuclear Information System (INIS)

    Combis, P.; Fronteau, J.

    1986-01-01

    A new numerical approach to Fokker-Planck equations is presented, in which the integration grid moves according to the solution of a differential system. The method is purely Lagrangian, the mean effect of the diffusion being inserted into the differential system itself

  6. Effect of heat treatment on bend stress relaxation of pure tungsten

    International Nuclear Information System (INIS)

    Sasaki, Kenta; Nogami, Shuhei; Fukuda, Makoto; Katakai, Yasuyuki; Hasegawa, Akira

    2013-01-01

    Highlights: • Bend stress relaxation test was performed on the pure tungsten after heat treatment for stress relief. • The BSR ratio of the heat treated specimen was larger than that of the as-received specimen at this temperature region. • Small reduction in the BSR ratio was observed at the temperatures of 500–800 °C. • The BSR ratio of the heat treated specimen decreased significantly at the temperatures of 900–1000 °C. • The BSR ratio decreased significantly in a short time below 0.1 h, and then decreased slowly. -- Abstract: Bend stress relaxation (BSR) tests at temperatures of 500, 600, 800, 900 and 1000 °C for 0.1, 0.5 and 1 h in vacuum were performed on the pure tungsten after heat treatment for stress relief at 900 °C for 1 h. The degree of stress relaxation increased with test temperature. The BSR ratio of the heat treated specimen was larger than that of the as-received specimen at this temperature region. Small reduction in the BSR ratio was observed at the temperatures of 500, 600 and 800 °C. The BSR ratio of the heat treated specimen decreased significantly at the temperatures of 900 and 1000 °C and it was close to that of the as-received specimen. The BSR ratio of the heat treated specimen and the as-received specimen exhibited similar trend of time-evolution. The stress was exponentially relaxed with increasing test time. The BSR ratio decreased significantly in a short time below 0.1 h, and then decreased slowly. Higher activation energy of stress relaxation evaluated by cross-cut method was obtained for the higher temperature

  7. Minimal covariant observables identifying all pure states

    Energy Technology Data Exchange (ETDEWEB)

    Carmeli, Claudio, E-mail: claudio.carmeli@gmail.com [D.I.M.E., Università di Genova, Via Cadorna 2, I-17100 Savona (Italy); I.N.F.N., Sezione di Genova, Via Dodecaneso 33, I-16146 Genova (Italy); Heinosaari, Teiko, E-mail: teiko.heinosaari@utu.fi [Turku Centre for Quantum Physics, Department of Physics and Astronomy, University of Turku (Finland); Toigo, Alessandro, E-mail: alessandro.toigo@polimi.it [Dipartimento di Matematica, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133 Milano (Italy); I.N.F.N., Sezione di Milano, Via Celoria 16, I-20133 Milano (Italy)

    2013-09-02

    It has been recently shown by Heinosaari, Mazzarella and Wolf (2013) [1] that an observable that identifies all pure states of a d-dimensional quantum system has minimally 4d−4 outcomes or slightly less (the exact number depending on d). However, no simple construction of this type of minimal observable is known. We investigate covariant observables that identify all pure states and have minimal number of outcomes. It is shown that the existence of this kind of observables depends on the dimension of the Hilbert space.

  8. Critical opalescence in the pure Coulomb system

    Science.gov (United States)

    Bobrov, V. B.; Trigger, S. A.

    2011-04-01

    Based on the dielectric formalism and quantum field theory methods, the phenomenon of critical opalescence is explained for light scattering in pure matter as a two-component electron-nuclear system with Coulomb interaction. A similar phenomenon is shown to occur in the case of neutron scattering in pure substances as well. The obtained results are valid for quantum case and arbitrary strong Coulomb interaction. Thus, the relations between structure factors derived for the electron-nuclear system are the exact result of the quantum statistical mechanics.

  9. Effective modeling and reverse-time migration for novel pure acoustic wave in arbitrary orthorhombic anisotropic media

    Science.gov (United States)

    Xu, Shigang; Liu, Yang

    2018-03-01

    The conventional pseudo-acoustic wave equations (PWEs) in arbitrary orthorhombic anisotropic (OA) media usually have coupled P- and SV-wave modes. These coupled equations may introduce strong SV-wave artifacts and numerical instabilities in P-wave simulation results and reverse-time migration (RTM) profiles. However, pure acoustic wave equations (PAWEs) completely decouple the P-wave component from the full elastic wavefield and naturally solve all the aforementioned problems. In this article, we present a novel PAWE in arbitrary OA media and compare it with the conventional coupled PWEs. Through decomposing the solution of the corresponding eigenvalue equation for the original PWE into an ellipsoidal differential operator (EDO) and an ellipsoidal scalar operator (ESO), the new PAWE in time-space domain is constructed by applying the combination of these two solvable operators and can effectively describe P-wave features in arbitrary OA media. Furthermore, we adopt the optimal finite-difference method (FDM) to solve the newly derived PAWE. In addition, the three-dimensional (3D) hybrid absorbing boundary condition (HABC) with some reasonable modifications is developed for reducing artificial edge reflections in anisotropic media. To improve computational efficiency in 3D case, we adopt graphic processing unit (GPU) with Compute Unified Device Architecture (CUDA) instead of traditional central processing unit (CPU) architecture. Several numerical experiments for arbitrary OA models confirm that the proposed schemes can produce pure, stable and accurate P-wave modeling results and RTM images with higher computational efficiency. Moreover, the 3D numerical simulations can provide us with a comprehensive and real description of wave propagation.

  10. Hardness and microstructure homogeneity of pure copper processed by accumulative back extrusion

    International Nuclear Information System (INIS)

    Bazaz, B.; Zarei-Hanzaki, A.; Fatemi-Varzaneh, S.M.

    2013-01-01

    The present work deals with the microstructure evolution of a pure copper processed by a new severe plastic deformation method. A set of pure copper (99.99%) work-pieces with coarse-grained microstructures was processed by accumulative back extrusion (ABE) method at room temperature. The optical and scanning electron microscopy (SEM) and hardness measurements were utilized to study the microstructural evolution and hardness homogeneity. The results indicated that ABE is a capable process to provide a homogenous grain refined microstructure in pure copper. The observed grain refinement was discussed relying on the occurrence of dynamic restoration processes. The analysis of microstructure and hardness showed outstanding homogeneity improvement throughout the work-pieces as the consecutive ABE passes were applied. The homogeneity improvement was attributed to the propagation of the shear bands and also the heavily deformed regions. A reversing route was also applied in the ABE processing to investigate its effect on the development of microstructural homogeneity. Comparing to the conventional route, the application of the reversing route was found to yield better homogeneity after less passes of the process.

  11. Parameterizations for narrowband and broadband albedo of pure snow and snow containing mineral dust and black carbon

    Science.gov (United States)

    Dang, Cheng; Brandt, Richard E.; Warren, Stephen G.

    2015-06-01

    The reduction of snow spectral albedo by black carbon (BC) and mineral dust, both alone and in combination, is computed using radiative transfer modeling. Broadband albedo is shown for mass fractions covering the full range from pure snow to pure BC and pure dust, and for snow grain radii from 5 µm to 2500 µm, to cover the range of possible grain sizes on planetary surfaces. Parameterizations are developed for opaque homogeneous snowpacks for three broad bands used in general circulation models and several narrower bands. They are functions of snow grain radius and the mass fraction of BC and/or dust and are valid up to BC content of 10 ppm, needed for highly polluted snow. A change of solar zenith angle can be mimicked by changing grain radius. A given mass fraction of BC causes greater albedo reduction in coarse-grained snow; BC and grain radius can be combined into a single variable to compute the reduction of albedo relative to pure snow. The albedo reduction by BC is less if the snow contains dust, a common situation on mountain glaciers and in agricultural and grazing lands. Measured absorption spectra of mineral dust are critically reviewed as a basis for specifying dust properties for modeling. The effect of dust on snow albedo at visible wavelengths can be represented by an "equivalent BC" amount, scaled down by a factor of about 200. Dust has little effect on the near-IR albedo because the near-IR albedo of pure dust is similar to that of pure snow.

  12. Compact objects in pure Lovelock theory

    Science.gov (United States)

    Dadhich, Naresh; Hansraj, Sudan; Chilambwe, Brian

    For static fluid interiors of compact objects in pure Lovelock gravity (involving only one Nth order term in the equation), we establish similarity in solutions for the critical odd and even d = 2N + 1, 2N + 2 dimensions. It turns out that in critical odd d = 2N + 1 dimensions, there cannot exist any bound distribution with a finite radius, while in critical even d = 2N + 2 dimensions, all solutions have similar behavior. For exhibition of similarity, we would compare star solutions for N = 1, 2 in d = 4 Einstein and d = 6 in Gauss-Bonnet theory, respectively. We also obtain the pure Lovelock analogue of the Finch-Skea model.

  13. Purely elastic scattering theories and their ultraviolet limits

    International Nuclear Information System (INIS)

    Klassen, T.R.; Chicago Univ., IL; Melzer, E.

    1990-01-01

    We use the thermodynamic Bethe ansatz to find the finite-size corrections to the ground-state energy in an arbitrary (1+1)-dimensional purely elastic scattering theory. The leading finite-size effects are characterized by tilde c=c-12d 0 , where c and d 0 are the central charge and the lowest scaling dimension, respectively, of the (possibly nonunitary) CFT describing the ultraviolet limit of the massive scattering theory. After presenting the purely elastic S-matrix theories that emerged in recent discussions of perturbed CFTs, we calculate their finite-size scaling coefficient tilde c. Our results show that the UV limits of the 'minimal' S-matrix theories are the unperturbed CFTs in question. On the other hand, the S-matrices which have been suggested to describe affine Toda field theories, differing from the minimal S-matrices by coupling-dependent factors, are seen to have free bosonic CFTs as their UV limits. We also discuss some interesting properties of tilde c. In particular, we suggest that tilde c is a measure of the number of degrees of freedom of an arbitrary two-dimensional CFT. (orig.)

  14. Essential oils have different effects on human pathogenic and commensal bacteria in mixed faecal fermentations compared with pure cultures.

    Science.gov (United States)

    Thapa, Dinesh; Louis, Petra; Losa, Riccardo; Zweifel, Béatrice; Wallace, R John

    2015-02-01

    A static batch culture system inoculated with human faeces was used to determine the influence of essential oil compounds (EOCs) on mixed faecal microbiota. Bacteria were quantified using quantitative PCR of 16S rRNA genes. Incubation for 24 h of diluted faeces from six individuals caused enrichment of Bifidobacterium spp., but proportions of other major groups were unaffected. Thymol and geraniol at 500 p.p.m. suppressed total bacteria, resulting in minimal fermentation. Thymol at 100 p.p.m. had no effect, nor did eugenol or nerolidol at 100 or 500 p.p.m. except for a slight suppression of Eubacterium hallii. Methyl isoeugenol at 100 or 500 p.p.m. suppressed the growth of total bacteria, accompanied by a large fall in the molar proportion of propionate formed. The relative abundance of Faecalibacterium prausnitzii was unaffected except with thymol at 500 p.p.m. The ability of EOCs to control numbers of the pathogen Clostridium difficile was investigated in a separate experiment, in which the faecal suspensions were amended by the addition of pure culture of C. difficile. Numbers of C. difficile were suppressed by thymol and methyl isoeugenol at 500 p.p.m. and to a lesser extent at 100 p.p.m. Eugenol and geraniol gave rather similar suppression of C. difficile numbers at both 100 and 500 p.p.m. Nerolidol had no significant effect. It was concluded from these and previous pure-culture experiments that thymol and geraniol at around 100 p.p.m. could be effective in suppressing pathogens in the small intestine, with no concern for beneficial commensal colonic bacteria in the distal gut. © 2015 The Authors.

  15. On pure spinor formalism for quantum superstring and spinor moving frame

    International Nuclear Information System (INIS)

    Bandos, Igor A

    2013-01-01

    The D = 10 pure spinor constraint can be solved in terms of spinor moving frame variables v -α q and eight-component complex null vector Λ + q , Λ + q Λ + q =0, which can be related to the κ-symmetry ghost. Using this and similar solutions for the conjugate pure spinor and other elements of the non-minimal pure spinor formalism, we present a (hopefully useful) reformulation of the measure of the pure spinor path integral for superstring in terms of products of Cartan forms corresponding to the coset of 10D Lorentz group and to the coset of complex orthogonal group SO(8, C). Our study suggests a possible complete reformulation of the pure spinor superstring in terms of new irreducible set of variable. (paper)

  16. Cohomology in the Pure Spinor Formalism for the Superstring

    International Nuclear Information System (INIS)

    Berkovits, Nathan

    2000-01-01

    A manifestly super-Poincare covariant formalism for the superstring has recently been constructed using a pure spinor variable. Unlike the covariant Green-Schwarz formalism, this new formalism is easily quantized with a BRST operator and tree-level scattering amplitudes have been evaluated in a manifestly covariant manner. In this paper, the cohomology of the BRST operator in the pure spinor formalism is shown to give the usual light-cone Green-Schwarz spectrum. Although the BRST operator does not directly involve the Virasoro constraint, this constraint emerges after expressing the pure spinor variable in terms of SO(8) variables. (author)

  17. Spark plasma sintering of pure and doped tungsten as plasma facing material

    Science.gov (United States)

    Autissier, E.; Richou, M.; Minier, L.; Naimi, F.; Pintsuk, G.; Bernard, F.

    2014-04-01

    In the current water cooled divertor concept, tungsten is an armour material and CuCrZr is a structural material. In this work, a fabrication route via a powder metallurgy process such as spark plasma sintering is proposed to fully control the microstructure of W and W composites. The effect of chemical composition (additives) and the powder grain size was investigated. To reduce the sintering temperature, W powders doped with a nano-oxide dispersion of Y2O3 are used. Consequently, the sintering temperature for W-oxide dispersed strengthened (1800 °C) is lower than for pure W powder. Edge localized mode tests were performed on pure W and compared to other preparation techniques and showed promising results.

  18. Epistatic participation of REV1 and REV3 in the formation of UV-induced frameshift mutations in cell cycle-arrested yeast cells

    Energy Technology Data Exchange (ETDEWEB)

    Heidenreich, Erich [Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna (Austria)]. E-mail: erich.heidenreich@meduniwien.ac.at; Eisler, Herfried [Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna (Austria); Steinboeck, Ferdinand [Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna (Austria)

    2006-01-29

    Mutations arising in times of cell cycle arrest may provide a selective advantage for unicellular organisms adapting to environmental changes. For multicellular organisms, however, they may pose a serious threat, in that such mutations in somatic cells contribute to carcinogenesis and ageing. The budding yeast Saccharomyces cerevisiae presents a convenient model system for studying the incidence and the mechanisms of stationary-phase mutation in a eukaryotic organism. Having studied the emergence of frameshift mutants after several days of starvation-induced cell cycle arrest, we previously reported that all (potentially error-prone) translesion synthesis (TLS) enzymes identified in S. cerevisiae did not contribute to the basal level of spontaneous stationary-phase mutations. However, we observed that an increased frequency of stationary-phase frameshift mutations, brought about by a defective nucleotide excision repair (NER) pathway or by UV irradiation, was dependent on Rev3p, the catalytic subunit of the TLS polymerase zeta (Pol {zeta}). Employing the same two conditions, we now examined the effect of deletions of the genes coding for polymerase eta (Pol {eta}) (RAD30) and Rev1p (REV1). In a NER-deficient strain background, the increased incidence of stationary-phase mutations was only moderately influenced by a lack of Pol {eta} but completely reduced to wild type level by a knockout of the REV1 gene. UV-induced stationary-phase mutations were abundant in wild type and rad30{delta} strains, but substantially reduced in a rev1{delta} as well as a rev3{delta} strain. The similarity of the rev1{delta} and the rev3{delta} phenotype and an epistatic relationship evident from experiments with a double-deficient strain suggests a participation of Rev1p and Rev3p in the same mutagenic pathway. Based on these results, we propose that the response of cell cycle-arrested cells to an excess of exo- or endogenously induced DNA damage includes a novel replication

  19. Design Efficient and Ultralong Pure Organic Room-Temperature Phosphorescent Materials by Structural Isomerism.

    Science.gov (United States)

    Xiong, Yu; Zhao, Zheng; Zhao, Wei Jun; Ma, Hui Li; Peng, Qian; He, Zi Kai; Zhang, Xue Peng; Chen, Yun Cong; He, Xue Wen; Lam, Jacky; Tang, Ben Zhong

    2018-05-08

    Pure organic materials with ultralong room temperature phosphorescence (RTP) are attractive alternatives to inorganic phosphors. However, without heavy atoms and carbonyl or heteroatomic groups, they generally show inefficient intersystem crossing (ISC) due to the weak spin-orbit coupling (SOC). Many efforts have been made to enhance SOC but examples in realizing both efficient and ultralong RTP have been limited. Here we present a novel design principle based on the realization of small energy gap between the lowest singlet and triplet states (ΔEST) and pure ππ* configuration of the lowest triplet state (T1) via structural isomerism to obtain efficient and ultralong RTP materials. The meta-isomer of carbazole-substituted methyl benzoate exhibits an ultralong lifetime of 795.0 ms with a quantum yield of 2.1%, whose performance is among the best RTP materials reported so far. Study on the structure-property relationship demonstrates that the varied steric and conjugation effects imposed by ester substituent at different positions are responsible for the small ΔEST and pure ππ* configuration of T1. This rational design will open a new avenue for exploring novel pure organic RTP materials. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Social phobia, panic disorder and suicidality in subjects with pure and depressive mania.

    Science.gov (United States)

    Dilsaver, Steven C; Chen, Yuan-Who

    2003-11-01

    The objective of this study is to ascertain the rates of social phobia, panic disorder and suicidality in the midst of the manic state among subjects with pure and depressive mania. Subjects received evaluations entailing the use of serial standard clinical interviews, the Schedule for Affective Disorders and Schizophrenia (SADS) and a structured interview to determine whether they met the criteria for intra-episode social phobia (IESP) and panic disorder (IEPD). The diagnoses of major depressive disorder and mania were rendered using the Research Diagnostic Criteria. The diagnoses of IESP and IEPD were rendered using DSM-III-R criteria. Categorization as being suicidal was based on the SADS suicide subscale score. Twenty-five (56.8%) subjects had pure and 19 (43.2%) subjects had depressive mania. None of the subjects with pure and 13 (68.4%) with depressive mania had IESP (Pdepressive mania had IEPD (Pdepressive were suicidal. Twelve of 13 (92.3%) subjects with depressive mania met the criteria for IESP and IEPD concurrently (Pdepressive but not pure mania exhibited high rates of both IESP and IEPD. Concurrence of the disorders is the rule. The findings suggest that databases disclosing a relationship between panic disorder and suicidality merit, where possible, reanalysis directed at controlling for the effect of social phobia.

  1. Radiation resistivity of pure silica core image guides for industrial fiberscopes

    International Nuclear Information System (INIS)

    Okamoto, Shinichi; Ohnishi, Tokuhiro; Kanazawa, Tamotsu; Tsuji, Yukio; Hayami, Hiroyuki; Ishitani, Tadayoshi; Akutsu, Takeji; Suzuki, Koichi.

    1991-01-01

    Industrial fiberscopes incorporating pure silica core image guides have been extensively used for remote visual inspection in radiation fields including nuclear power plants, owing to their superior radiation resistivity. The authors have been intensively conducting R and D on improving radiation resistivity of pure silica core image guides. This paper reports the results of experiments to compare the effects of core materials on radiation resistivity and to investigate the dependence of radiation resistivity on total dose, does rate, and support pipe material. The results confirmed the superior radiation resistivity of the core material containing fluorine at any irradiation condition and indicated the existence of a critical dose rate at which radiation-induced deterioration was stabilized. No difference in radiation resistivity attributable to support layer material was observed. (author)

  2. Properties and distribution of pure GA-sequences of mammalian genomes.

    Directory of Open Access Journals (Sweden)

    Guenter Albrecht-Buehler

    Full Text Available The article describes DNA sequences of mammalian genomes that are longer than 50 bases, but consist exclusively of G's and A's ('pure GA-sequences'. Although their frequency of incidence should be 10(-16 or smaller, the chromosomes of human, chimpanzee, dog, cat, rat, and mouse contained many tens of thousands of them ubiquitously located along the chromosomes with a species-dependent density, reaching sizes of up to 1300 [b]. With the exception of a small number of poly-A-, poly-G-, poly-GA-, and poly-GAAA-sequences (combined <0.5%, all pure GA-sequences of the mammals tested were unique individuals, contained several repeated short GA-containing motifs, and shared a common hexa-nucleotide spectrum. At most 2% of the human GA-sequences were transcribed into mRNAs; all others were not coding for proteins. Although this could have made them less subject to natural selection, they contained many [corrected] times fewer point mutations than one should expect from the genome at large. As to the presence of other sequences with similarly restricted base contents, there were approximately as many pure TC-sequences as pure GA-sequences, but many fewer pure AC-, TA, and TG-sequences. There were practically no pure GC-sequences. The functions of pure GA-sequences are not known. Supported by a number of observations related to heat shock phenomena, the article speculates that they serve as genomic sign posts which may help guide polymerases and transcription factors to their proper targets, and/or as spatial linkers that help generate the 3-dimensional organization of chromatin.

  3. Effects of oregano oil, carvacrol, cinnamaldehyde, and citral on antimicrobial, mechanical and barrier properties of carrot puree films

    Science.gov (United States)

    Wang, Xinwei; Liu, Huan; Wei, Jing; Ma, Zhongsu

    2011-02-01

    The effects against staphfloccus aureus and escherichia coli of oregano oil, carvacrol, cinnamaldehyde, and citral in chitosan-corn starch-gelatin-carrot puree films at 0.5% to 3% (w/w) concentrations were investigated along with the mechanical and barrier properties of the films. The presence of oregano oil, carvacrol, cinnamaldehyde, and citral did not change the good oxygen barrier of the films, but did significantly modify tensile properties and water vapor permeability, and made films darker. The data also show that the antimicrobial activities were in the following order: cinnamaldehyde > carvacrol > oregano oil > citral. Moreover, the antimicrobial films were more effective against staphfloccus aureus than against the escherichia coli. This study showed that oregano oil, carvacrol, cinnamaldehyde, and citral, especially the first three, could be used to prepare antimicrobial edible films for food applications.

  4. The effect of additives in silages of pure timothy and timothy mixed with red clover on chemical composition and in vitro rumen fermentation characteristics

    NARCIS (Netherlands)

    Hetta, M.; Cone, J.W.; Gustavsson, A.M.; Martinsson, K.

    2003-01-01

    The aim was to compare the effects of additives on direct cut silages of pure timothy and timothy mixed with tetraploid red clover. First and second growth cuts were ensiled during three consecutive years, 1994, 1995 and 1996, either without any additive or with the addition of formic acid, or

  5. Prediction of mechanical properties in friction stir welds of pure copper

    International Nuclear Information System (INIS)

    Heidarzadeh, A.; Saeid, T.

    2013-01-01

    Highlights: • Range of parameters for defect-free friction stir welded pure copper was reached. • Models were developed for predicting UTS, TE and hardness of pure copper joints. • Analysis of variance was used to validate the developed models. • Effect of welding parameters on mechanical behavior of welded joints was explored. • The microstructure and fracture surface of welded joints were investigated. - Abstract: This research was carried out to predict the mechanical properties of friction stir welded pure copper joints. Response surface methodology based on a central composite rotatable design with three parameters, five levels, and 20 runs, was used to conduct the experiments and to develop the mathematical regression model by using of Design-Expert software. The three welding parameters considered were rotational speed, welding speed, and axial force. Analysis of variance was applied to validate the predicted models. Microstructural characterization and fractography of joints were examined using optical and scanning electron microscopes. Also, the effects of the welding parameters on mechanical properties of friction stir welded joints were analyzed in detail. The results showed that the developed models were reasonably accurate. The increase in welding parameters resulted in increasing of tensile strength of the joints up to a maximum value. Elongation percent of the joints increased with increase of rotational speed and axial force, but decreased by increasing of welding speed, continuously. In addition, hardness of the joints decreased with increase of rotational speed and axial force, but increased by increasing of welding speed. The joints welded at higher heat input conditions revealed more ductility fracture mode

  6. Visual processing in pure alexia

    DEFF Research Database (Denmark)

    Starrfelt, Randi; Habekost, Thomas; Gerlach, Christian

    2010-01-01

    affected. His visual apprehension span was markedly reduced for letters and digits. His reduced visual processing capacity was also evident when reporting letters from words. In an object decision task with fragmented pictures, NN's performance was abnormal. Thus, even in a pure alexic patient with intact...

  7. Electron Acoustic Waves in Pure Ion Plasmas

    Science.gov (United States)

    Anderegg, F.; Driscoll, C. F.; Dubin, D. H. E.; O'Neil, T. M.

    2009-11-01

    Electron Acoustic Waves (EAW) are the low frequency branch of electrostatic plasma waves. These waves exist in neutralized plasmas, pure electron plasmas and in pure ion plasmasfootnotetextF. Anderegg et al., PRL 102, 095001 (2009) and PoP 16, 055705 (2009). (where the name is deceptive). Here, we observe standing mθ= 0 mz= 1 EAWs in a pure ion plasma column. At small amplitude, the EAWs have a phase velocity vph ˜1.4 v, and the frequencies are in close agreement with theory. At moderate amplitudes, waves can be excited over a broad range of frequencies, with observed phase velocities in the range of 1.4 v vph diagnostic shows that particles slower than vph oscillate in phase with the wave, while particles moving faster than vph oscillate 180^o out of phase with the wave. From a fluid perspective, this gives an unusual negative dynamical compressibility. That is, the wave pressure oscillations are 180^o out of phase from the density oscillations, almost fully canceling the electrostatic restoring force, giving the low and malleable frequency.

  8. Some structural characteristics of gamma-irradiated pure and Li2O-doped NiO solids

    International Nuclear Information System (INIS)

    Ramadan, A.A.; Dessouki, A.M.

    1989-01-01

    The induced structural changes, due to Li 2 O-doping (2.5 mol%) and γ-irradiation (10-80 Mrad), of NiO were investigated by XRD analyses. The results obtained revealed that lithium-doping resulted in a significant increase in the internal strain and a decrease in lattice parameter. These changes were explained in terms of creation of Ni 3+ ions in the doped solids. γ-Irradiation of pure and doped solids effected a decrease in both crystallite size and microstrain upon subjecting to doses of 20 and 30 Mrad. Higher doses induced an increase in both parameters in the case of pure NiO and a further decrease in case of the doped solid. These results were attributed to splitting of the large strained crystallites and to an activated sintering of the small strained ones. γ-Irradiation effected also an increase in the lattice parameters of pure and doped solids due to removal of some excess oxygen with subsequent decrease in the concentration of Ni 3+ ions. (author)

  9. Pure spinor formalism as an N = 2 topological string

    International Nuclear Information System (INIS)

    Berkovits, Nathan

    2005-01-01

    Following suggestions of Nekrasov and Siegel, a non-minimal set of fields are added to the pure spinor formalism for the superstring. Twisted c-circumflex = 3 N = 2 generators are then constructed where the pure spinor BRST operator is the fermionic spin-one generator, and the formalism is interpreted as a critical topological string. Three applications of this topological string theory include the super-Poincare covariant computation of multiloop superstring amplitudes without picture-changing operators, the construction of a cubic open superstring field theory without contact-term problems, and a new four-dimensional version of the pure spinor formalism which computes F-terms in the spacetime action

  10. Deriving CSW rules for massive scalar legs and pure Yang-Mills loops

    International Nuclear Information System (INIS)

    Boels, Rutger; Schwinn, Christian

    2008-01-01

    This article provides two complementary detailed derivations of Cachazo-Svrcek-Witten-style Feynman rules for Yang-Mills gauge theory coupled to a massive coloured scalar as presented in earlier work. These proceed through a direct canonical transformation method on space-time and through a gauge transformation in an action constructed on twistor space. It is shown explicitly that the field transformations are identical in both cases. Some simple tree-level examples of our rules are given and we comment on the application of them to the calculation of the rational part of one-loop pure glue amplitudes. A possible direct quantum completion of pure glue CSW rules based on dimensional regularisation motivated by these results is sketched. Finally, it is shown how to derive CSW rules for effective Higgs-gluon and Higgs-matter couplings proposed in the literature directly from the action. This derivation yields additional towers of vertices which generate a subset of the contributions to effective multi-Higgs scattering amplitudes.

  11. Pure soliton solutions of some nonlinear partial differential equations

    International Nuclear Information System (INIS)

    Fuchssteiner, B.

    1977-01-01

    A general approach is given to obtain the system of ordinary differential equations which determines the pure soliton solutions for the class of generalized Korteweg-de Vries equations. This approach also leads to a system of ordinary differential equations for the pure soliton solutions of the sine-Gordon equation. (orig.) [de

  12. Field-Assisted Splitting of Pure Water Based on Deep-Sub-Debye-Length Nanogap Electrochemical Cells.

    Science.gov (United States)

    Wang, Yifei; Narayanan, S R; Wu, Wei

    2017-08-22

    Owing to the low conductivity of pure water, using an electrolyte is common for achieving efficient water electrolysis. In this paper, we have fundamentally broken through this common sense by using deep-sub-Debye-length nanogap electrochemical cells to achieve efficient electrolysis of pure water (without any added electrolyte) at room temperature. A field-assisted effect resulted from overlapped electrical double layers can greatly enhance water molecules ionization and mass transport, leading to electron-transfer limited reactions. We have named this process "virtual breakdown mechanism" (which is completely different from traditional mechanisms) that couples the two half-reactions together, greatly reducing the energy losses arising from ion transport. This fundamental discovery has been theoretically discussed in this paper and experimentally demonstrated in a group of electrochemical cells with nanogaps between two electrodes down to 37 nm. On the basis of our nanogap electrochemical cells, the electrolysis current density from pure water can be significantly larger than that from 1 mol/L sodium hydroxide solution, indicating the much better performance of pure water splitting as a potential for on-demand clean hydrogen production.

  13. Nigeria Journal of Pure and Applied Physics: About this journal

    African Journals Online (AJOL)

    Nigeria Journal of Pure and Applied Physics: About this journal. Journal Home > Nigeria Journal of Pure and Applied Physics: About this journal. Log in or Register to get access to full text downloads.

  14. Micro-Arc Oxidation Enhances the Blood Compatibility of Ultrafine-Grained Pure Titanium

    Directory of Open Access Journals (Sweden)

    Lin Xu

    2017-12-01

    Full Text Available Ultrafine-grained pure titanium prepared by equal-channel angular pressing has favorable mechanical performance and does not contain alloy elements that are toxic to the human body. It has potential clinical value in applications such as cardiac valve prostheses, vascular stents, and hip prostheses. To overcome the material’s inherent thrombogenicity, surface-coating modification is a crucial pathway to enhancing blood compatibility. An electrolyte solution of sodium silicate + sodium polyphosphate + calcium acetate and the micro-arc oxidation (MAO technique were employed for in situ oxidation of an ultrafine-grained pure titanium surface. A porous coating with anatase- and rutile-phase TiO2 was generated and wettability and blood compatibility were examined. The results showed that, in comparison with ultrafine-grained pure titanium substrate, the MAO coating had a rougher surface, smaller contact angles for distilled water and higher surface energy. MAO modification effectively reduced the hemolysis rate; extended the dynamic coagulation time, prothrombin time (PT, and activated partial thromboplastin time (APTT; reduced the amount of platelet adhesion and the degree of deformation; and enhanced blood compatibility. In particular, the sample with an oxidation time of 9 min possessed the highest surface energy, largest PT and APTT values, smallest hemolysis rate, less platelet adhesion, a lesser degree of deformation, and more favorable blood compatibility. The MAO method can significantly enhance the blood compatibility of ultrafine-grained pure titanium, increasing its potential for practical applications.

  15. Pure type systems with subtyping

    NARCIS (Netherlands)

    Zwanenburg, J.; Girard, J.-Y.

    1999-01-01

    We extend the framework of Pure Type Systems with subtyping, as found in F = ¿ . This leads to a concise description of many existing systems with subtyping, and also to some new interesting systems. We develop the meta-theory for this framework, including Subject Reduction and Minimal Typing. The

  16. Some aspects of anelastic and microplastic creep of pure Al and two Al-alloys

    Energy Technology Data Exchange (ETDEWEB)

    Sgobba, S. (Lab. de Metallurgie Mecanique, Dept. des Materiaux, Ecole Polytechnique Federale de Lausanne (Switzerland)); Kuenzi, H.U. (Lab. de Metallurgie Mecanique, Dept. des Materiaux, Ecole Polytechnique Federale de Lausanne (Switzerland)); Ilschner, B. (Lab. de Metallurgie Mecanique, Dept. des Materiaux, Ecole Polytechnique Federale de Lausanne (Switzerland))

    1993-11-01

    Anelastic creep of pure Al, commercial Al-Cu and a binary Al-Cu alloy has been measured at room temperature by means of a high resolution laser interferometer. The irreversible component of the deformation was also quantified from measurements of the anelastic creep recovery. The dependence of the deformation-time curves on thermal treatment and cold work is analyzed. The mechanisms responsible for the room temperature anelastic creep are discussed. Materials loaded below their elastic limit can present either a pure anelastic behavior (commercial Al-Cu) or additional viscoelastic creep (pure Al, high purity Al-Cu). For commercial Al-Cu, the presence of an irreversible deformation appears to be mainly related to the state of the surface. A viscoelastic after effect has been measured for this alloy after a Cu-electroplating treatment. As a typical result for room temperature creep, the irreversible deformation depends logarithmically on load time. (orig.).

  17. Some aspects of anelastic and microplastic creep of pure Al and two Al-alloys

    International Nuclear Information System (INIS)

    Sgobba, S.; Kuenzi, H.U.; Ilschner, B.

    1993-01-01

    Anelastic creep of pure Al, commercial Al-Cu and a binary Al-Cu alloy has been measured at room temperature by means of a high resolution laser interferometer. The irreversible component of the deformation was also quantified from measurements of the anelastic creep recovery. The dependence of the deformation-time curves on thermal treatment and cold work is analyzed. The mechanisms responsible for the room temperature anelastic creep are discussed. Materials loaded below their elastic limit can present either a pure anelastic behavior (commercial Al-Cu) or additional viscoelastic creep (pure Al, high purity Al-Cu). For commercial Al-Cu, the presence of an irreversible deformation appears to be mainly related to the state of the surface. A viscoelastic after effect has been measured for this alloy after a Cu-electroplating treatment. As a typical result for room temperature creep, the irreversible deformation depends logarithmically on load time. (orig.)

  18. Exchange-Dominated Pure Spin Current Transport in Alq3 Molecules.

    Science.gov (United States)

    Jiang, S W; Liu, S; Wang, P; Luan, Z Z; Tao, X D; Ding, H F; Wu, D

    2015-08-21

    We address the controversy over the spin transport mechanism in Alq3 utilizing spin pumping in the Y3Fe5O12/Alq3/Pd system. An unusual angular dependence of the inverse spin Hall effect is found. It, however, disappears when the microwave magnetic field is fully in the sample plane, excluding the presence of the Hanle effect. Together with the quantitative temperature-dependent measurements, these results provide compelling evidence that the pure spin current transport in Alq3 is dominated by the exchange-mediated mechanism.

  19. Research on the Applicable Method of Valuation of Pure Electric Used vehicles

    Science.gov (United States)

    Cai, yun; Tan, zhengping; Wang, yidong; Mao, pan

    2018-03-01

    With the rapid growth in the ownership of pure electric vehicles, the research on the valuation of used electric vehicles has become the key to the development of the pure electric used vehicle market. The paper analyzed the application of the three value assessment methods, current market price method, capitalized earning method and replacement cost method, in pure electric used vehicles, and draws a conclusion that the replacement cost method is more suitable for pure electric used car. At the same time, the article also conducted a parametric correction exploration research, aiming at the characteristics of pure electric vehicles and replacement cost of the constituent factors. Through the analysis of the applicability parameters of physical devaluation, functional devaluation and economic devaluation, the revised replacement cost method can be used for the valuation of purely used electric vehicles for private use.

  20. Quasinormal modes in pure de Sitter spacetimes

    International Nuclear Information System (INIS)

    Du Daping; Wang Bin; Su Ruheng

    2004-01-01

    We have studied scalar perturbations as well as fermion perturbations in pure de Sitter spacetimes. For scalar perturbations we have shown that well-defined quasinormal modes in d-dimensions can exist provided that the mass of scalar field m>(d-1/2l). The quasinormal modes of fermion perturbations in three and four dimensional cases have also been investigated. We found that different from other dimensional cases, in the three dimensional pure de Sitter spacetime there is no quasinormal mode for the s-wave. This interesting difference caused by the spacial dimensions is true for both scalar and fermion perturbations

  1. Moessbauer effect in pure and impurity doped FeSi2

    International Nuclear Information System (INIS)

    Blaauw, C.; Hanson, H.; Woude, F. van der

    1975-01-01

    Numerical values of the calculated and experimentally determined Moessbauer parameters for pure β-FeSi 2 and α-FeSi 2 are given. Temperature dependence of isomer shift and quadrupole splitting for the two Fe positions in β-FeSi 2 is presented. For α-FeSi 2 only average values are given. Spectra of Co- and Al-doped FeSi 2 recorded at 80, 293, 557 and 788 K were analyzed in the same manner as those of undoped FeSi 2 . The average values of isomer shift and quadrupole splitting in Co- and Al-doped β-FeSi 2 (α-Fesi 2 ) were compared to those found in undoped β-FeSi 2 (α-FeSi 2 ). All data were based on the room temperature spectra. Changes in Moessbauer parameters of doped samples relative to undoped ones were generally small, being of the order of hundredths of mm/sec. (Z.S.)

  2. Nigeria Journal of Pure and Applied Physics: Editorial Policies

    African Journals Online (AJOL)

    Focus and Scope. Nigeria Journal of Pure and Applied Physics publishes papers of the highest quality and significance in specific areas of physics, pure and applied, as listed below. The journal content reflects core physics disciplines, but is also open to a broad range of topics whose central theme falls within the bounds ...

  3. Production of tomato puree: an alternative to conservation of locally ...

    African Journals Online (AJOL)

    Mo

    suggest a mean of conservation of the surplus of production by processing tomato into puree. The most produced local ... processing into puree on industrial scale. The main .... functions contributing to the reaction of non-enzymatic browning ...

  4. Effect of adjustable molecular chain structure and pure silica zeolite nanoparticles on thermal, mechanical, dielectric, UV-shielding and hydrophobic properties of fluorinated copolyimide composites

    Science.gov (United States)

    Li, Qing; Liao, Guangfu; Zhang, Shulai; Pang, Long; Tong, Hao; Zhao, Wenzhe; Xu, Zushun

    2018-01-01

    A series of polyimide (PI) films, polyimide/pure silica zeolite nanoparticles (PSZN) blend films and polyimide/amine-functionalized pure silica zeolite nanoparticles (APSZN) composite films were successfully prepared by random copolycondensation. Thereinto, PSZN were synthesized by hydrothermal method. The polyimides were derived from 4,4‧-diaminodiphenyl ether (ODA), and three adjustable molar ratios (3:1, 1:1, 1:3) of 2,2-bis[4-(3,4-dicarboxyphenoxy)phenyl] propane dianhydride (BPADA) and 4,4‧-(hexafluoroisopropylidene) diphthalic anhydride (6FDA). The effects of PSZN, APSZN and different chain structure on PI films were specifically evaluated in terms of morphology, thermal, mechanical, dielectric and UV-shielding properties, etc. Comparison was given among pure PI flims, PI/PSZN blend films and PI/APSZN composite flims. The results showed that the thermal and mechanical properties of PI films were drastically impaired after adding PSZN. On the contrary, the strength, toughness and thermal stability were improved after adding APSZN. Moreover, the dielectric constants of the PI/APSZN composite flims were lowered but UV-shielding properties were enhanced. Interestingly, we found that the greatest effects were obtained through introducing APSZN in PI derived by the 1:1 ratio of BPADA:6FDA. The corresponding PI/APSZN composite flim exhibited the most reinforced and toughened properties, the largest decrement of dielectric constant and the best UV-shielding efficiency, which made the composite flim be used as ultraviolet shielding material in outer space filled with high temperature and intensive ultraviolet light. Meanwhile, this work also provided a facile way to synthesize composite materials with adjustable performance.

  5. International Standardization of Pure Beta Emitters

    International Nuclear Information System (INIS)

    Los Arcos, Jose Maria; Rodriguez, Leonor

    2006-01-01

    The paper describes the traditional methods of standardization of Pure Beta Emitters, their principal characteristics, advantage and drawbacks. It does comparisons between two metrological LSC methods: Triple to double coincidence ratio (TDCR) method and the CIEMAT/NIST method and presents the result obtained with several Key Comparisons serving as practical test of both methods. Both of them represent the siferrit of methods of standardization of pure (and mixed decay) radionuclides. ESIR WG of CCRI(II) is to implement a reference exchange system for the permanent equivalence of β, α and electron capture nuclides, similar to traditional SIR gamma. ESIR project is currently testing a new XAN scintillator and operational tests of the whole system at BIPM are expected by the end of 2006 (test restricted to ESIR NMI members)

  6. Purely Functional Structured Programming

    OpenAIRE

    Obua, Steven

    2010-01-01

    The idea of functional programming has played a big role in shaping today's landscape of mainstream programming languages. Another concept that dominates the current programming style is Dijkstra's structured programming. Both concepts have been successfully married, for example in the programming language Scala. This paper proposes how the same can be achieved for structured programming and PURELY functional programming via the notion of LINEAR SCOPE. One advantage of this proposal is that m...

  7. An economic CVD technique for pure SnO 2 thin films deposition

    Indian Academy of Sciences (India)

    A modified new method of CVD for formation of pure layers of tin oxide films was developed. This method is very simple and inexpensive and produces films with good electrical properties. The effect of substrate temperature on the sheet resistance, resistivity, mobility, carrier concentration and transparency of the films has ...

  8. The structure of the world from pure numbers

    International Nuclear Information System (INIS)

    Tipler, F J

    2005-01-01

    I investigate the relationship between physics and mathematics. I argue that physics can shed light on the proper foundations of mathematics, and that the nature of number can constrain the nature of physical reality. I show that requiring the joint mathematical consistency of the Standard Model of particle physics and the DeWitt-Feynman-Weinberg theory of quantum gravity can resolve the horizon, flatness and isotropy problems of cosmology. Joint mathematical consistency naturally yields a scale-free, Gaussian, adiabatic perturbation spectrum, and more matter than antimatter. I show that consistency requires the universe to begin at an initial singularity with a pure SU(2) L gauge field. I show that quantum mechanics requires this field to have a Planckian spectrum whatever its temperature. If this field has managed to survive thermalization to the present day, then it would be the cosmic microwave background radiation (CMBR). If so, then we would have a natural explanation for the dark matter and the dark energy. I show that isotropic ultrahigh energy cosmic rays are explained if the CMBR is a pure SU(2) L gauge field. The SU(2) L nature of the CMBR may have been seen in the Sunyaev-Zel'dovich effect. I propose several simple experiments to test the hypothesis

  9. DEVELOPMENT OF VEGETABLE PUREES AND DRINKS BY LACTIC ACID FERMENTATION

    Directory of Open Access Journals (Sweden)

    At. Kraevska

    2014-03-01

    Full Text Available The object of this work was to investigate the possibility for development of vegetable purees and drinks by lactic acid fermentation. It was found that by the direct lactic acid fermentation of Lb.plantarum strain 226/1 the vitamin composition of vegetable purees is preserved and the biological value is increased. Drinks, prepared from fermented vegetable purees were remarkable with the pleasant lactic acid taste, the sucrose-acid composition was stable and balanced and they can be used both in the rational and in the dietary nutrition.

  10. Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue.

    Science.gov (United States)

    Scuotto, M; Persico, M; Bucci, M; Vellecco, V; Borbone, N; Morelli, E; Oliviero, G; Novellino, E; Piccialli, G; Cirino, G; Varra, M; Fattorusso, C; Mayol, L

    2014-07-28

    Herein, we report optically pure modified acyclic nucleosides as ideal probes for aptamer modification. These new monomers offer unique advantages in exploring the role played in thrombin inhibition by a single residue modification at key positions of the TBA structure.

  11. Microstructure and mechanical properties of commercially pure aluminum processed by accumulative back extrusion

    International Nuclear Information System (INIS)

    Haghdadi, N.; Zarei-Hanzaki, A.; Abou-Ras, D.

    2013-01-01

    Accumulative back extrusion (ABE), as a new severe plastic deformation (SPD) method, was applied on a commercially pure aluminum, resulting in an ultrafine microstructure. The grain refinement was attributed to the shearing and/or to the mechanical partitioning of the initial coarse grains as well as different dynamic recrystallization mechanisms (i.e., discontinues and continues ones). The effects of imposing several passes along with the strain reversal path method during consecutive ABE passes were discussed. Mechanical characterization revealed that the yield and ultimate strength of pure Al were significantly increased through applying ABE. This was related to grain boundary and dislocation strengthening, as well as to Orowan dislocation bowing mechanisms. The elongation, however, was deteriorated after ABE processing. This was interpreted through the lack of ability of the material to accommodate the ABE-induced strain, inhomogeneous distribution of strain across the ABE-processed workpieces, and the reduced work hardening capacity of the fine-grained aluminum. The formability index and static toughness were also considered to verify the overall mechanical performance of the ABE-processed pure Al

  12. Dense Pure Tungsten Fabricated by Selective Laser Melting

    Directory of Open Access Journals (Sweden)

    Dianzheng Wang

    2017-04-01

    Full Text Available Additive manufacturing using tungsten, a brittle material, is difficult because of its high melting point, thermal conductivity, and oxidation tendency. In this study, pure tungsten parts with densities of up to 18.53 g/cm3 (i.e., 96.0% of the theoretical density were fabricated by selective laser melting. In order to minimize balling effects, the raw polyhedral tungsten powders underwent a spheroidization process before laser consolidation. Compared with polyhedral powders, the spherical powders showed increased laser absorptivity and packing density, which helped in the formation of a continuous molten track and promoted densification.

  13. Initial singularity and pure geometric field theories

    Science.gov (United States)

    Wanas, M. I.; Kamal, Mona M.; Dabash, Tahia F.

    2018-01-01

    In the present article we use a modified version of the geodesic equation, together with a modified version of the Raychaudhuri equation, to study initial singularities. These modified equations are used to account for the effect of the spin-torsion interaction on the existence of initial singularities in cosmological models. Such models are the results of solutions of the field equations of a class of field theories termed pure geometric. The geometric structure used in this study is an absolute parallelism structure satisfying the cosmological principle. It is shown that the existence of initial singularities is subject to some mathematical (geometric) conditions. The scheme suggested for this study can be easily generalized.

  14. Effect of Cell-to-matrix Ratio in Polyvinyl Alcohol Immobilized Pure and Mixed Cultures on Atrazine Degradation

    International Nuclear Information System (INIS)

    Siripattanakul, Sumana; Wirojanagud, Wanpen; McEvoy, John; Khan, Eakalak

    2008-01-01

    Atrazine biodegradation by immobilized pure and mixed cultures was examined. A pure atrazine-degrading culture, Agrobacterium radiobacter J14a (J14a), and a mixed culture (MC), isolated from an atrazine-contaminated crop field, were immobilized using phosphorylated-polyvinyl alcohol (PPVA). An existing cell immobilization procedure was modified to enhance PPVA matrix stability. The results showed that the matrices remained mechanically and chemically stable after shaking with glass beads over 15 days under various salt solutions and pH values. The immobilization process had a slight effect on cell viability. With the aid of scanning electron microscopy, a suitable microstructure of PPVA matrices for cell entrapment was observed. There were two porous layers of spherical gel matrices, the outside having an encapsulation property and the inside containing numerous pores for bacteria to occupy. J14a and MC were immobilized at three cell-to-matrix ratios of 3.5, 6.7, and 20 mg dry cells/mL matrix. The atrazine biodegradation tests were conducted in an aerobic batch system, which was inoculated with cells at 2,000 mg/L. The tests were also conducted using free (non-immobilized) J14a and MC for comparative purpose. The cell-to-matrix ratio of 3.5 mg/mL provided the highest atrazine removal efficiency of 40-50% in 120 h for both J14a and MC. The free cell systems, for both cultures, presented much lower atrazine removal efficiencies compared to the immobilized cell systems at the same level of inoculation

  15. Topological M Theory from Pure Spinor Formalism

    CERN Document Server

    Grassi, P A; Grassi, Pietro Antonio; Vanhove, Pierre

    2005-01-01

    We construct multiloop superparticle amplitudes in 11d using the pure spinor formalism. We explain how this construction reduces to the superparticle limit of the multiloop pure spinor superstring amplitudes prescription. We then argue that this construction points to some evidence for the existence of a topological M theory based on a relation between the ghost number of the full-fledged supersymmetric critical models and the dimension of the spacetime for topological models. In particular, we show that the extensions at higher orders of the previous results for the tree and one-loop level expansion for the superparticle in 11 dimensions is related to a topological model in 7 dimensions.

  16. Multiloop amplitudes and vanishing theorems using the pure spinor formalism for the superstring

    International Nuclear Information System (INIS)

    Berkovits, Nathan

    2004-01-01

    A ten-dimensional super-Poincare covariant formalism for the superstring was recently developed which involves a BRST operator constructed from superspace matter variables and a pure spinor ghost variable. A super-Poincare covariant prescription was defined for computing tree amplitudes and was shown to coincide with the standard RNS prescription. In this paper, picture-changing operators are used to define functional integration over the pure spinor ghosts and to construct a suitable b ghost. A super-Poincare covariant prescription is then given for the computation of N-point multiloop amplitudes. One can easily prove that massless N-point multiloop amplitudes vanish for N 4 terms in the effective action receive no perturbative contributions above one loop. (author)

  17. Crystal structure of pure ZrO2 nanopowders

    International Nuclear Information System (INIS)

    Lamas, D.G.; Rosso, A.M.; Anzorena, M. Suarez; Fernandez, A.; Bellino, M.G.; Cabezas, M.D.; Walsoee de Reca, N.E.; Craievich, A.F.

    2006-01-01

    The crystal structure of pure (undoped) zirconia nanopowders synthesized by different wet-chemical routes has been investigated by synchrotron X-ray diffraction. Whereas some previous authors reported the retention of the cubic phase in similar materials, we demonstrate here that pure zirconia nanopowders with average crystallite sizes ranging from 5 to 10 nm exhibit the tetragonal phase. In addition, our results suggest that a tetragonal-to-cubic transition for decreasing crystallite size could eventually occur at a very small critical crystallite size

  18. An economic CVD technique for pure SnO2 thin films deposition ...

    Indian Academy of Sciences (India)

    An economic CVD technique for pure SnO2 thin films deposition: Temperature effects ..... C are depicted in figure 7. It is observed that the cut-off wave- ... cating that the energy gap of the SnO2 films varies among. 3·54, 3·35 and 1·8 eV.

  19. Graphical calculus for Gaussian pure states

    International Nuclear Information System (INIS)

    Menicucci, Nicolas C.; Flammia, Steven T.; Loock, Peter van

    2011-01-01

    We provide a unified graphical calculus for all Gaussian pure states, including graph transformation rules for all local and semilocal Gaussian unitary operations, as well as local quadrature measurements. We then use this graphical calculus to analyze continuous-variable (CV) cluster states, the essential resource for one-way quantum computing with CV systems. Current graphical approaches to CV cluster states are only valid in the unphysical limit of infinite squeezing, and the associated graph transformation rules only apply when the initial and final states are of this form. Our formalism applies to all Gaussian pure states and subsumes these rules in a natural way. In addition, the term 'CV graph state' currently has several inequivalent definitions in use. Using this formalism we provide a single unifying definition that encompasses all of them. We provide many examples of how the formalism may be used in the context of CV cluster states: defining the 'closest' CV cluster state to a given Gaussian pure state and quantifying the error in the approximation due to finite squeezing; analyzing the optimality of certain methods of generating CV cluster states; drawing connections between this graphical formalism and bosonic Hamiltonians with Gaussian ground states, including those useful for CV one-way quantum computing; and deriving a graphical measure of bipartite entanglement for certain classes of CV cluster states. We mention other possible applications of this formalism and conclude with a brief note on fault tolerance in CV one-way quantum computing.

  20. The effect of couple-stress on the pure bending of a prismatic bar

    International Nuclear Information System (INIS)

    Tzung, F.K.; Kao, B.; Ho, F.; Tang, P.

    1981-01-01

    An evaluation of the applicability of the couple-stress theory to the stress analysis of graphite structures is performed by solving a pure bending problem. The differences between solutions from the couple-stress theory and from the classical theory of elasticity are compared. It is found that the differences are sufficient to account for the inconsistencies which have often been observed between the classical elasticity theory and actual behavior of graphite under bend and tensile loadings. An experimental procedure to measure the material constants in the couple-stress theory is also suggested. (orig.)

  1. UV-induced lethal sectoring and pure mutant clones in yeast.

    Science.gov (United States)

    Hannan, M A; Duck, P; Nasim, A

    1976-08-01

    The induction of lethal sectoring and pure mutant clones by ultraviolet light has been studied in a homogeneous G1 population of Saccharomyces cerevisiae grown in a normal growth medium. At the lowest UV dose of 250 ergs, which corresponds to a shoulder in the survival curve, all mutants appeared as pure clones. At higher doses the frequency of mosaic mutants progressively increased. These results indicate a relationship between the highest frequency of complete mutants and the maximum repair activity. In addition, the frequency of lethal sectoring at all doses tested was too low to account for the origin of pure mutant clones.

  2. The Mosaic Ancestry of the Drosophila Genetic Reference Panel and the D. melanogaster Reference Genome Reveals a Network of Epistatic Fitness Interactions

    Science.gov (United States)

    Pool, John E.

    2015-01-01

    North American populations of Drosophila melanogaster derive from both European and African source populations, but despite their importance for genetic research, patterns of ancestry along their genomes are largely undocumented. Here, I infer geographic ancestry along genomes of the Drosophila Genetic Reference Panel (DGRP) and the D. melanogaster reference genome, which may have implications for reference alignment, association mapping, and population genomic studies in Drosophila. Overall, the proportion of African ancestry was estimated to be 20% for the DGRP and 9% for the reference genome. Combining my estimate of admixture timing with historical records, I provide the first estimate of natural generation time for this species (approximately 15 generations per year). Ancestry levels were found to vary strikingly across the genome, with less African introgression on the X chromosome, in regions of high recombination, and at genes involved in specific processes (e.g., circadian rhythm). An important role for natural selection during the admixture process was further supported by evidence that many unlinked pairs of loci showed a deficiency of Africa–Europe allele combinations between them. Numerous epistatic fitness interactions may therefore exist between African and European genotypes, leading to ongoing selection against incompatible variants. By focusing on hubs in this network of fitness interactions, I identified a set of interacting loci that include genes with roles in sensation and neuropeptide/hormone reception. These findings suggest that admixed D. melanogaster samples could become an important study system for the genetics of early-stage isolation between populations. PMID:26354524

  3. AKUMULASI TIMBAL (PB DAN STRUKTUR STOMATA DAUN PURING (CODIAEUM VARIEGATUM LAM. BLUME

    Directory of Open Access Journals (Sweden)

    Susi Sulistiana

    2016-12-01

    Full Text Available Tanaman mempunyai kemampuan untuk mengatasi atau mengeliminir pencemaran udara yang terjadi di kota, salah satunya adalah tanaman puring. Stomata adalah salah satu organ tumbuhan yang digunakan untuk berinteraksi dengan lingkungannya. Fungsi utama stomata adalah sebagai tempat pertukaran gas, seperti CO2 yang diperlukan oleh tumbuhan dalam proses fotosintesis. Namun, stomata juga bertindak sebagai salah satu jalur masuknya polutan khususnya polutan yang berasal dari udara. Untuk mempertegas pengaruh akumulasi timbal terhadap daun tanaman puring secara morfologi yang telah dilakukan oleh Sulistiana dan Setijorini tahun 2014, perlu dilakukan penelitian lanjutan dengan melakukan pengamatan anatomi daun terutama struktur stomata daun tanaman puring. Penelitian bertujuan membandingkan struktur stomata antar kultivar puring dan membuktikan adanya hubungan antara akumulasi timbal (Pb dengan struktur stomata daun dari beberapa kultivar puring. Bahan penelitian yang digunakan adalah daun segar dari 13 kultivar tanaman puring yang ditanam di Perumahan Batan Indah, Kecamatan Kademangan, Tangerang Selatan. Pengamatan struktur stomata daun dilakukan dengan cara pembuatan preparat paradermal Parameter yang diamati dalam penelitian meliputi jumlah stomata, jumlah sel epidermis, panjang stomata, lebar stomata, indeks stomata, dan kerapatan stomata. Hasil yang diperoleh adanya korelasi positif antara kadar Pb dan struktur stomata daun kultivar puring melalui parameter-paramater yang diamati terutama jumlah stomata, lebar stomata, indeks stomata, dan kerapatan stomata.

  4. Effect of protective gas on the properties of the pure support of super-martensitic stainless steel

    International Nuclear Information System (INIS)

    Zappa, Sebastian; Svoboda, Hernan G; Ramini de Rissone, N.Mabel; Surian, Estela S; De Vedia, Luis A

    2006-01-01

    This work studied the effect of protective gas on the operability, mechanical properties and microstructure of the super-martensitic stainless pure support metal, deposited with a metal-cored tubular wire, using the semi-automatic welding process under gaseous protection. Three pure support test tubes were welded following ANSI/AWS A5.22-95, with a 1.2 mm diameter tubular wire using three gaseous mixtures as protection: 70 % Ar-30 % He, 98 % Ar-2 % Co 2 and 82 % Ar-18 % Co 2 . The welding position was by hand with an average thermal support of 1.1 kJ/mm. Transverse cuts were extracted from each welded coupon for metallography and chemical composition, 1 'Minitrac' traction test piece and about 20 test pieces for a V-Charpy impact trial. The microstructure was defined with optic and scanning electronic microscopes and with X-ray diffraction. Micro hardness profiles were determined as well as the properties in traction and on impact. With reference to operability, the number of spatters increased noticeably with an increased content of Co 2 in the protective mixture. The content of Mn, Si and Mo dropped after increasing the gas oxidation potential. Regarding the mechanical properties small variations in the flow limit, the resistance to traction and the hardness for the different gaseous mixtures used were observed. A slight drop in the absorbed energy, with an increase in the Co2 content in the protective gas was noted in the V-Charpy impact tests carried out at 20, 0, -20, -40 and -60 o C. Expressions were obtained that correlated the measured properties with the oxidation potential of the gas for these materials. The microstructure consists of martensite, ferrite and retained austenite. Significant variations were not observed in the ferrite and austenite fractions for the different gases that were used (CW)

  5. pH-dependent antibacterial effects on oral microorganisms through pure PLGA implants and composites with nanosized bioactive glass.

    Science.gov (United States)

    Hild, Nora; Tawakoli, Pune N; Halter, Jonas G; Sauer, Bärbel; Buchalla, Wolfgang; Stark, Wendelin J; Mohn, Dirk

    2013-11-01

    Biomaterials made of biodegradable poly(α-hydroxyesters) such as poly(lactide-co-glycolide) (PLGA) are known to decrease the pH in the vicinity of the implants. Bioactive glass (BG) is being investigated as a counteracting agent buffering the acidic degradation products. However, in dentistry the question arises whether an antibacterial effect is rather obtained from pure PLGA or from BG/PLGA composites, as BG has been proved to be antimicrobial. In the present study the antimicrobial properties of electrospun PLGA and BG45S5/PLGA fibres were investigated using human oral bacteria (specified with mass spectrometry) incubated for up to 24 h. BG45S5 nanoparticles were prepared by flame spray synthesis. The change in colony-forming units (CFU) of the bacteria was correlated with the pH of the medium during incubation. The morphology and structure of the scaffolds as well as the appearance of the bacteria were followed bymicroscopy. Additionally, we studied if the presence of BG45S5 had an influence on the degradation speed of the polymer. Finally, it turned out that the pH increase induced by the presence of BG45S5 in the scaffold did not last long enough to show a reduction in CFU. On the contrary, pure PLGA demonstrated antibacterial properties that should be taken into consideration when designing biomaterials for dental applications. Copyright © 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

  6. Transport mechanism of lipid covered saquinavir pure drug nanoparticles in intestinal epithelium

    DEFF Research Database (Denmark)

    Xia, Dengning; He, Yuan; Li, Qiuxia

    2018-01-01

    are transported. To improve cellular uptake and transport of pure nanodrug in cells, here, a lipid covered saquinavir (SQV) pure drug NP (Lipo@nanodrug) was designed by modifying a pure SQV NP (nanodrug) with a phospholipid bilayer. We studied their endocytosis, intracellular trafficking mechanism using Caco-2...... their intracellular processing, helping to improve drug transport across intestinal epithelium. To our knowledge, this is the first presentation of the novel phospholipid bilayer covered SQV pure drug NP design, and a mechanistic study on intracellular trafficking in in vitro cell models has been described......Pure drug nanoparticles (NPs) represent a promising formulation for improved drug solubility and controlled dissolution velocity. However, limited absorption by the intestinal epithelium remains challenge to their clinical application, and little is known about how these NPs within the cells...

  7. Synthesis and Absolute Configuration of Enantiomerically Pure Vitamin K3 2,3-Epoxide

    NARCIS (Netherlands)

    Snatzke, Günther; Wijnberg, Hans; Feringa, Bernard; Marsman, Bea G.; Greydanus, Ben; Pluim, Henk

    1980-01-01

    The 2,3-epoxide of vitamin K3 (menadione, 1) has been prepared in enantiomerically pure form, and the absolute configuration has been deduced from the CD spectrum. The compound with the negative Cotton effect between 340 and 400 nm has the 2R,3S configuration.

  8. Structural, optical and dielectric properties of pure and chromium (Cr) doped nickel oxide nanoparticles

    Science.gov (United States)

    Gupta, Jhalak; Ahmed, Arham S.

    2018-05-01

    The pure and Cr doped nickel oxide (NiO) nanoparticles have been synthesized by cost effective co-precipitation method having nickel nitrate as initial precursor. The synthesized samples were characterized by X-Ray diffraction (XRD), UV-Visible Spectroscopy(UV-Vis) and LCR meter for structural, optical and dielectric properties respectively. The crystallite size of pure nickel oxide nanoparticles characterized by XRD using Debye Scherer's formula was found to be 21.7nm and the same decreases on increasing Cr concentration whereas optical and dielectric properties were analyzed by UV-Vis and LCR meter respectively. The energy band gaps were determined by UV-Vis using Tauc relation.

  9. Scattering equations, supergravity integrands, and pure spinors

    Energy Technology Data Exchange (ETDEWEB)

    Adamo, Tim; Casali, Eduardo [Department of Applied Mathematics & Theoretical Physics, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA (United Kingdom)

    2015-05-25

    The tree-level S-matrix of type II supergravity can be computed in scattering equation form by correlators in a worldsheet theory analogous to a chiral, infinite tension limit of the pure spinor formalism. By defining a non-minimal version of this theory, we give a prescription for computing correlators on higher genus worldsheets which manifest space-time supersymmetry. These correlators are conjectured to provide the loop integrands of supergravity scattering amplitudes, supported on the scattering equations. We give non-trivial evidence in support of this conjecture at genus one and two with four external states. Throughout, we find a close correspondence with the pure spinor formalism of superstring theory, particularly regarding regulators and zero-mode counting.

  10. Scattering equations, supergravity integrands, and pure spinors

    International Nuclear Information System (INIS)

    Adamo, Tim; Casali, Eduardo

    2015-01-01

    The tree-level S-matrix of type II supergravity can be computed in scattering equation form by correlators in a worldsheet theory analogous to a chiral, infinite tension limit of the pure spinor formalism. By defining a non-minimal version of this theory, we give a prescription for computing correlators on higher genus worldsheets which manifest space-time supersymmetry. These correlators are conjectured to provide the loop integrands of supergravity scattering amplitudes, supported on the scattering equations. We give non-trivial evidence in support of this conjecture at genus one and two with four external states. Throughout, we find a close correspondence with the pure spinor formalism of superstring theory, particularly regarding regulators and zero-mode counting.

  11. Difficulties in applying pure Kohn-Sham density functional theory electronic structure methods to protein molecules

    Science.gov (United States)

    Rudberg, Elias

    2012-02-01

    Self-consistency-based Kohn-Sham density functional theory (KS-DFT) electronic structure calculations with Gaussian basis sets are reported for a set of 17 protein-like molecules with geometries obtained from the Protein Data Bank. It is found that in many cases such calculations do not converge due to vanishing HOMO-LUMO gaps. A sequence of polyproline I helix molecules is also studied and it is found that self-consistency calculations using pure functionals fail to converge for helices longer than six proline units. Since the computed gap is strongly correlated to the fraction of Hartree-Fock exchange, test calculations using both pure and hybrid density functionals are reported. The tested methods include the pure functionals BLYP, PBE and LDA, as well as Hartree-Fock and the hybrid functionals BHandHLYP, B3LYP and PBE0. The effect of including solvent molecules in the calculations is studied, and it is found that the inclusion of explicit solvent molecules around the protein fragment in many cases gives a larger gap, but that convergence problems due to vanishing gaps still occur in calculations with pure functionals. In order to achieve converged results, some modeling of the charge distribution of solvent water molecules outside the electronic structure calculation is needed. Representing solvent water molecules by a simple point charge distribution is found to give non-vanishing HOMO-LUMO gaps for the tested protein-like systems also for pure functionals.

  12. Difficulties in applying pure Kohn-Sham density functional theory electronic structure methods to protein molecules

    International Nuclear Information System (INIS)

    Rudberg, Elias

    2012-01-01

    Self-consistency-based Kohn-Sham density functional theory (KS-DFT) electronic structure calculations with Gaussian basis sets are reported for a set of 17 protein-like molecules with geometries obtained from the Protein Data Bank. It is found that in many cases such calculations do not converge due to vanishing HOMO-LUMO gaps. A sequence of polyproline I helix molecules is also studied and it is found that self-consistency calculations using pure functionals fail to converge for helices longer than six proline units. Since the computed gap is strongly correlated to the fraction of Hartree-Fock exchange, test calculations using both pure and hybrid density functionals are reported. The tested methods include the pure functionals BLYP, PBE and LDA, as well as Hartree-Fock and the hybrid functionals BHandHLYP, B3LYP and PBE0. The effect of including solvent molecules in the calculations is studied, and it is found that the inclusion of explicit solvent molecules around the protein fragment in many cases gives a larger gap, but that convergence problems due to vanishing gaps still occur in calculations with pure functionals. In order to achieve converged results, some modeling of the charge distribution of solvent water molecules outside the electronic structure calculation is needed. Representing solvent water molecules by a simple point charge distribution is found to give non-vanishing HOMO-LUMO gaps for the tested protein-like systems also for pure functionals. (fast track communication)

  13. Entanglement measure for general pure multipartite quantum states

    International Nuclear Information System (INIS)

    Heydari, Hoshang; Bjoerk, Gunnar

    2004-01-01

    We propose an explicit formula for a measure of entanglement of pure multipartite quantum states. We discuss the mathematical structure of the measure and give a brief explanation of its physical motivation. We apply the measure on some pure, tripartite, qubit states and demonstrate that, in general, the entanglement can depend on what actions are performed on the various subsystems, and specifically if the parties in possession of the subsystems cooperate or not. We also give some simple but illustrative examples of the entanglement of four-qubit and m-qubit states

  14. Pure spinors, free differential algebras, and the supermembrane

    International Nuclear Information System (INIS)

    Fre, Pietro; Grassi, Pietro Antonio

    2007-01-01

    The Lagrangian formalism for the supermembrane in any 11d supergravity background is constructed in the pure spinor framework. Our gauge-fixed action is manifestly BRST, supersymmetric, and 3d Lorentz invariant. The relation between the Free Differential Algebras (FDA) underlying 11d supergravity and the BRST symmetry of the membrane action is exploited. The 'gauge-fixing' has a natural interpretation as the variation of the Chevalley cohomology class needed for the extension of 11d super-Poincare superalgebra to M-theory FDA. We study the solution of the pure spinor constraints in full detail

  15. Creep mechanisms and constitutive relations in pure metals

    International Nuclear Information System (INIS)

    Nix, W.D.

    1979-01-01

    The mechanisms of creep of pure metals is briefly reviewed and divided into two parts: steady state flow mechanisms, and non-steady state flow mechanisms and constitutive relations. Creep by diffusional flow is now reasonably well understood, with theory and experiment in good agreement. The closely related phenomenon of Harper--Dorn creep can also be understood in terms of diffusion between dislocations. Power law creep involves the climb of edge disloctions controlled by lattice self diffusion. Theoretical treatments of this process invariably give a power law exponent of 3. This natural creep law is compared with the data for FCC and BCC metals. It is suggested that diffusion controlled climb is the controlling process in BCC metals at very high temperatures. Stacking fault energy effects may preclude the possibility that creep is controlled entirely by lattice self diffusion in some FCC metals. The subject of power law breakdown is presented as a natural consequence of the transition to low temperature flow phenomena. The role of core diffusion in this transition is briefly discussed. The mechanisms are presented by which pure metals creep at elevated temperatures. While most of this review deals with the mechanisms of steady state flow, some discussion is devoted to creep flow under non-steady state conditions. This topic is discussed in connection with the development of constitutive equations for describing plastic flow in metals

  16. Pure state condition for the semi-classical Wigner function

    International Nuclear Information System (INIS)

    Ozorio de Almeida, A.M.

    1982-01-01

    The Wigner function W(p,q) is a symmetrized Fourier transform of the density matrix e(q 1 ,q 2 ), representing quantum-mechanical states or their statistical mixture in phase space. Identification of these two alternatives in the case of density matrices depends on the projection identity e 2 = e; its Wigner correspondence is the pure state condition. This criterion is applied to the Wigner functions botained from standard semiclassical wave functions, determining as pure states those whose classical invariant tori satisfy the generalized Bohr-Sommerfeld conditions. Superpositions of eigenstates are then examined and it is found that the Wigner function corresponding to Gaussian random wave functions are smoothed out in the manner of mixedstate Wigner functions. Attention is also given to the pure-state condition in the case where an angular coordinate is used. (orig.)

  17. ZnCr2S4: Highly effective photocatalyst converting nitrate into N2 without over-reduction under both UV and pure visible light.

    Science.gov (United States)

    Yue, Mufei; Wang, Rong; Cheng, Nana; Cong, Rihong; Gao, Wenliang; Yang, Tao

    2016-08-03

    We propose several superiorities of applying some particular metal sulfides to the photocatalytic nitrate reduction in aqueous solution, including the high density of photogenerated excitons, high N2 selectivity (without over-reduction to ammonia). Indeed, ZnCr2S4 behaved as a highly efficient photocatalyst, and with the assistance of 1 wt% cocatalysts (RuOx, Ag, Au, Pd, or Pt), the efficiency was greatly improved. The simultaneous loading of Pt and Pd led to a synergistic effect. It offered the highest nitrate conversion rate of ~45 mg N/h together with the N2 selectivity of ~89%. Such a high activity remained steady after 5 cycles. The optimal apparent quantum yield at 380 nm was 15.46%. More importantly, with the assistance of the surface plasma resonance effect of Au, the visible light activity achieved 1.352 mg N/h under full arc Xe-lamp, and 0.452 mg N/h under pure visible light (λ > 400 nm). Comparing to the previous achievements in photocatalytic nitrate removal, our work on ZnCr2S4 eliminates the over-reduction problem, and possesses an extremely high and steady activity under UV-light, as well as a decent conversion rate under pure visible light.

  18. ZnCr2S4: Highly effective photocatalyst converting nitrate into N2 without over-reduction under both UV and pure visible light

    Science.gov (United States)

    Yue, Mufei; Wang, Rong; Cheng, Nana; Cong, Rihong; Gao, Wenliang; Yang, Tao

    2016-08-01

    We propose several superiorities of applying some particular metal sulfides to the photocatalytic nitrate reduction in aqueous solution, including the high density of photogenerated excitons, high N2 selectivity (without over-reduction to ammonia). Indeed, ZnCr2S4 behaved as a highly efficient photocatalyst, and with the assistance of 1 wt% cocatalysts (RuOx, Ag, Au, Pd, or Pt), the efficiency was greatly improved. The simultaneous loading of Pt and Pd led to a synergistic effect. It offered the highest nitrate conversion rate of ~45 mg N/h together with the N2 selectivity of ~89%. Such a high activity remained steady after 5 cycles. The optimal apparent quantum yield at 380 nm was 15.46%. More importantly, with the assistance of the surface plasma resonance effect of Au, the visible light activity achieved 1.352 mg N/h under full arc Xe-lamp, and 0.452 mg N/h under pure visible light (λ > 400 nm). Comparing to the previous achievements in photocatalytic nitrate removal, our work on ZnCr2S4 eliminates the over-reduction problem, and possesses an extremely high and steady activity under UV-light, as well as a decent conversion rate under pure visible light.

  19. Image tuning techniques for enhancing the performance of pure permanent magnet undulators with small gap/period ratios

    Energy Technology Data Exchange (ETDEWEB)

    Tatchyn, R. [Stanford Univ., CA (United States)

    1995-12-31

    The on-axis field of a small-gap undulator constricted out of pure permanent magnet (PM) blocks arranged in an alternating-dipole (i.e., 2 dipoles/period) array can be substantially varied by positioning monolithic permeable plates above and below the undulator jaws. This simple technique, which can be used to control the 1st harmonic energy in conventional synchrotron radiation (SR) or Free Electron Laser (FEL) applications requiring sub-octave tuning, can also be shown to suppress magnetic inhomogeneities that can contribute to the undulator`s on-axis field errors. If a standard 4 block/period Halbach undulator, composed of PM blocks with square cross sections, is rearranged into an alternating-dipole array with the same period, the peak field that can be generated with superimposed image plates can substantially exceed that of the pure-PM Halbach array. This design technique, which can be viewed as intermediate between the {open_quotes}pure-PM{close_quotes} and standard {open_quotes}hybrid/PM{close_quotes} configurations, provides a potentially cost-effective method of enhancing the performance of small-gap, pure-PM insertion devices. In this paper we report on the analysis and recent characterization of pure-PM undulator structures with superimposed image plates, and discuss possible applications to FEL research.

  20. Positron Annihilation Lifetime Study of Pure and Doped Polyvinyl Chloride with Al2O3

    International Nuclear Information System (INIS)

    Abdel-Hady, E.E.; Hamdy, F. M. M.; Alaa, H.B.

    2005-01-01

    Positron annihilation lifetime of pure and doped polyvinyl chloride (PVC) with Al 2 O 3 reflect the effect of concentration as well as temperature on free volume. Therefore, variations of the ortho-positronium (o-Ps) lifetime and its intensity have been correlated with changes in the dielectric properties of the pure and doped PVC. The o-Ps lifetime and its intensity show a linear dependence with a discontinuity at 20 % concentration of Al 2 O 3 . The size and the fractional of the o-Ps hole volume were estimated from the positron annihilation parameters. Therefore, the temperature dependence of the electrical conductivity and the positron annihilation parameters on pure and doped PVC with 20 % Al 2 O 3 were studied in the range from 20 to 140 degree C. The shift of the glass transition temperature to lower temperature for the 20 % Al 2 O 3 doped PVC might explain the increase in the electrical conductivity with the concentration of the additive

  1. Shrinkage of spray-freeze-dried microparticles of pure protein for ballistic injection by manipulation of freeze-drying cycle.

    Science.gov (United States)

    Straller, Georg; Lee, Geoffrey

    2017-10-30

    Spray-freeze-drying was used to produce shrivelled, partially-collapsed microparticles of pure proteins that may be suitable for use in a ballistic injector. Various modifications of the freeze drying cycle were examined for their effects on collapse of the pure protein microparticles. The use of annealing at a shelf temperature of up to +10°C resulted in no visible particle shrinkage. This was because of the high T g ' of the pure protein. Inclusion of trehalose or sucrose led to particle shrinkage because of the plasticizing effects of the disaccharides on the protein. Only by extending the duration of primary drying from 240 to 2745min at shelf temperatures in the range -12 to -8°C were shrivelled, wrinkled particles of bSA and bCA of reduced porosity obtained. Manipulation of the freeze-drying cycle used for SFD can therefore be used to modify particle morphology and increase particle density. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Solution thermodynamics of valnemulin hydrogen fumarate in different pure solvents

    International Nuclear Information System (INIS)

    Ouyang, Jinbo; Wang, Jingkang; Huang, Xin; Bao, Ying; Wang, Yongli; Yin, Qiuxiang; Liu, Ailing; Li, Xudong; Hao, Hongxun

    2015-01-01

    Highlights: • The solubility of valnemulin hydrogen fumarate in five pure solvents was experimentally determined. • The solubility data were correlated by Wilson model, NRTL model and UNIQUAC model. • Mixing thermodynamic properties of valnemulin hydrogen fumarate in five pure solvents were calculated. - Abstract: Solubility of valnemulin hydrogen fumarate in five pure solvents was determined within temperature range of (278.15 to 323.15) K by a gravimetric method. The results show that the solubility of valnemulin hydrogen fumarate in tested pure solvents increases with the increasing temperature. The solubility values were correlated by the Wilson model, NRTL model and UNIQUAC model. The UNIQUAC volume parameter, area parameter, and Wilson liquid molar volume parameter of valnemulin hydrogen fumarate were estimated by the group contribution method. It was found that the correlated results are in good agreement with the experimental results. Furthermore, the mixing thermodynamic properties of valnemulin hydrogen fumarate in solutions, including the mixing Gibbs energy, the mixing enthalpy and entropy, were determined by using the Wilson model and the experimental solubility results.

  3. Solubility of salicylic acid in pure alcohols at different temperatures

    International Nuclear Information System (INIS)

    Lim, Junhyuk; Jang, Sunghyun; Cho, Hye Kyoung; Shin, Moon Sam; Kim, Hwayong

    2013-01-01

    Highlights: ► Solubility data of salicylic acid in pure alkanols were measured. ► The experimental data were correlated with NRTL, UNIQUAC and Wilson models. ► The data are fit well with all three models for the six pure alcohols studied. ► Adjustable interaction parameters were suggested. - Abstract: This work focused on the experimental measurements and the numerical calculations of the solubility of salicylic acid in various alcohols. The solubility of salicylic acid in pure alcohols was determined using a (solid + liquid) equilibrium measurement apparatus at temperatures ranging from (278.15 to 318.15) K. Also, the melting temperature and fusion enthalpy of salicylic acid were determined by a differential scanning calorimeter (TA instrument Q100). The experimental results were correlated with the equation for solubility of a solid in a liquid with the nonrandom two liquid (NRTL), universal quasi-chemical (UNIQUAC) and Wilson models for liquid phase activity coefficients to validate the quality of the data taken. Adjustable interaction parameters were also provided. The experimental data fit appropriately with all three models for the pure alcohols studied.

  4. Effects of Improving Primary Health Care Workers’ Knowledge About Public Health Services in Rural China: A Comparative Study of Blended Learning and Pure E-Learning

    Science.gov (United States)

    Zhan, Xingxin; Zhang, Zhixia; Sun, Fang; Liu, Qian; Peng, Weijun; Zhang, Heng

    2017-01-01

    Background Primary health care workers (PHCWs) are a major force in delivering basic public health services (BPHS) in rural China. It is necessary to take effective training approaches to improve PHCWs’ competency on BPHS. Both electronic learning (e-learning) and blended learning have been widely used in the health workers’ education. However, there is limited evidence on the effects of blended learning in comparison with pure e-learning. Objective The aim of this study was to evaluate the effects of a blended-learning approach for rural PHCWs in improving their knowledge about BPHS as well as training satisfaction in comparison with a pure e-learning approach. Methods The study was conducted among PHCWs in 6 rural counties of Hubei Province, China, between August 2013 and April 2014. Three counties were randomly allocated blended-learning courses (29 township centers or 612 PHCWs—the experimental group), and three counties were allocated pure e-learning courses (31 township centers or 625 PHCWs—the control group). Three course modules were administered for 5 weeks, with assessments at baseline and postcourse. Primary outcomes were score changes in courses’ knowledge. Secondary outcome was participant satisfaction (5-point Likert scale anchored between 1 [strongly agree] and 5 [strongly disagree]). Results The experimental group had higher mean scores than the control group in knowledge achievement in three course modules: (1) module 1: 93.21 (95% CI 92.49-93.93) in experimental group versus 88.29 (95% CI 87.19-89.40) in the control group; adjusted difference, 4.92 (95% CI 2.61-7.24; Plearning group gave more positive responses with the four issues than control group participants: (1) the increase of interest in learning, 1.85 (95% CI 1.22-2.80; P=.003); (2) the increase of interaction with others, 1.77 (95% CI 1.20-2.60; P=.004); (3) the satisfaction with learning experience, 1.78 (95% CI 1.11-2.88; P=.02); and (4) achievement of learning objectives, 1

  5. Thermodynamic equilibrium of hydroxyacetic acid in pure and binary solvent systems

    International Nuclear Information System (INIS)

    Huang, Qiaoyin; Xie, Chuang; Li, Yang; Su, Nannan; Lou, Yajing; Hu, Xiaoxue; Wang, Yongli; Bao, Ying; Hou, Baohong

    2017-01-01

    Highlights: • Solubility of hydroxyacetic acid in mono-solvents and binary solvent mixtures was measured. • Modified Apelblat, NRTL and Wilson model were used to correlate the solubility data in pure solvents. • CNIBS/R-K and Jouyban-Acree model were used to correlate the solubility in binary solvent mixtures. • The mixing properties were calculated based on the NRTL model. - Abstract: The solubility of hydroxyacetic acid in five pure organic solvents and two binary solvent mixtures were experimentally measured from 273.15 K to 313.15 K at atmospheric pressure (p = 0.1 MPa) by using a dynamic method. The order of solubility in pure organic solvents is ethanol > isopropanol > n-butanol > acetonitrile > ethyl acetate within the investigated temperature range, except for temperature lower than 278 K where the solubility of HA in ethyl acetate is slightly larger than that in acetonitrile. Furthermore, the solubility data in pure solvents were correlated with the modified Apelblat model, NRTL model, and Wilson model and that in the binary solvents mixtures were fitted to the CNIBS/R-K model and Jouyban-Acree model. Finally, the mixing thermodynamic properties of hydroxyacetic acid in pure and binary solvent systems were calculated and discussed.

  6. Global Journal of Pure and Applied Sciences

    African Journals Online (AJOL)

    Global Journal of Pure and Applied Sciences is a multi-disciplinary specialist journal ... research in Biological Science, Agricultural Sciences, Chemical Sciences, ... Comparative study of the physicochemical and bacteriological qualities of ...

  7. High-power pure blue laser diodes

    Energy Technology Data Exchange (ETDEWEB)

    Ohta, M.; Ohizumi, Y.; Hoshina, Y.; Tanaka, T.; Yabuki, Y.; Goto, S.; Ikeda, M. [Development Center, Sony Shiroishi Semiconductor Inc., Miyagi (Japan); Funato, K. [Materials Laboratories, Sony Corporation, Kanagawa (Japan); Tomiya, S. [Materials Analysis Laboratory, Sony Corporation, Kanagawa (Japan)

    2007-06-15

    We successfully developed high-power and long-lived pure blue laser diodes (LDs) having an emission wavelength of 440-450 nm. The pure-blue LDs were grown by metalorganic chemical vapor deposition (MOCVD) on GaN substrates. The dislocation density was successfully reduced to {proportional_to}10{sup 6} cm{sup -2} by optimizing the MOCVD growth conditions and the active layer structure. The vertical layer structure was designed to have an absorption loss of 4.9 cm{sup -1} and an internal quantum efficiency of 91%. We also reduced the operating current density to 6 kA/cm{sup 2} under 750 mW continuous-wave operation at 35 C by optimizing the stripe width to 12 {mu}m and the cavity length to 2000 {mu}m. The half lifetimes in constant current mode are estimated to be longer than 10000 h. (copyright 2007 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  8. Pure spinors, free differential algebras, and the supermembrane

    Energy Technology Data Exchange (ETDEWEB)

    Fre, Pietro [Dipartimento di Fisica Teorica, Universita di Torino, and INFN-Sezione di Torino, Via P. Giuria 1, I-10125 Turin (Italy); Grassi, Pietro Antonio [Centro Studi e Ricerche E. Fermi, Compendio Viminale, I-00184 Rome (Italy) and DISTA, Universita del Piemonte Orientale, and INFN-Sezione di Torino, Via Bellini 25/G, Alessandria 15100 (Italy) and CERN, Theory Unit, CH-1211 Geneva 23 (Switzerland)]. E-mail: pgrassi@insti.physics.sunysb.edu

    2007-02-12

    The Lagrangian formalism for the supermembrane in any 11d supergravity background is constructed in the pure spinor framework. Our gauge-fixed action is manifestly BRST, supersymmetric, and 3d Lorentz invariant. The relation between the Free Differential Algebras (FDA) underlying 11d supergravity and the BRST symmetry of the membrane action is exploited. The 'gauge-fixing' has a natural interpretation as the variation of the Chevalley cohomology class needed for the extension of 11d super-Poincare superalgebra to M-theory FDA. We study the solution of the pure spinor constraints in full detail.

  9. Probing photo-ionization: experiments on positive streamers in pure gases and mixtures

    International Nuclear Information System (INIS)

    Nijdam, S; Van de Wetering, F M J H; Blanc, R; Van Veldhuizen, E M; Ebert, U

    2010-01-01

    Positive streamers are thought to propagate by photo-ionization; the parameters of photo-ionization depend on the nitrogen : oxygen ratio. Therefore we study streamers in nitrogen with 20%, 0.2% and 0.01% oxygen and in pure nitrogen as well as in pure oxygen and argon. Our new experimental set-up guarantees contamination of the pure gases to be well below 1 ppm. Streamers in oxygen are difficult to measure as they emit considerably less light in the sensitivity range of our fast ICCD camera than the other gases. Streamers in pure nitrogen and in all nitrogen-oxygen mixtures look generally similar, but become somewhat thinner and branch more with decreasing oxygen content. In pure nitrogen the streamers can branch so much that they resemble feathers. This feature is even more pronounced in pure argon, with approximately 10 2 hair tips cm -3 in the feathers at 200 mbar; this density can be interpreted as the free electron density creating avalanches towards the streamer stem. It is remarkable that the streamer velocity is essentially the same for similar voltage and pressure in all nitrogen-oxygen mixtures as well as in pure nitrogen, while the oxygen concentration and therefore the photo-ionization lengths vary by more than five orders of magnitude. Streamers in argon have essentially the same velocity as well. The physical similarity of streamers at different pressures is confirmed in all gases; the minimal diameters are smaller than in earlier measurements.

  10. Probing photo-ionization: experiments on positive streamers in pure gases and mixtures

    Energy Technology Data Exchange (ETDEWEB)

    Nijdam, S; Van de Wetering, F M J H; Blanc, R; Van Veldhuizen, E M; Ebert, U, E-mail: s.nijdam@tue.n [Eindhoven University of Technology, Department Applied Physics, PO Box 513, 5600 MB Eindhoven (Netherlands)

    2010-04-14

    Positive streamers are thought to propagate by photo-ionization; the parameters of photo-ionization depend on the nitrogen : oxygen ratio. Therefore we study streamers in nitrogen with 20%, 0.2% and 0.01% oxygen and in pure nitrogen as well as in pure oxygen and argon. Our new experimental set-up guarantees contamination of the pure gases to be well below 1 ppm. Streamers in oxygen are difficult to measure as they emit considerably less light in the sensitivity range of our fast ICCD camera than the other gases. Streamers in pure nitrogen and in all nitrogen-oxygen mixtures look generally similar, but become somewhat thinner and branch more with decreasing oxygen content. In pure nitrogen the streamers can branch so much that they resemble feathers. This feature is even more pronounced in pure argon, with approximately 10{sup 2} hair tips cm{sup -3} in the feathers at 200 mbar; this density can be interpreted as the free electron density creating avalanches towards the streamer stem. It is remarkable that the streamer velocity is essentially the same for similar voltage and pressure in all nitrogen-oxygen mixtures as well as in pure nitrogen, while the oxygen concentration and therefore the photo-ionization lengths vary by more than five orders of magnitude. Streamers in argon have essentially the same velocity as well. The physical similarity of streamers at different pressures is confirmed in all gases; the minimal diameters are smaller than in earlier measurements.

  11. [Allelopathic effects of the humus soils from Betula platyphylla and Quercus liaotungensis pure plantations on 9 kinds of common shrubs and herbs].

    Science.gov (United States)

    Huang, Liang-Jia; Liu, Zeng-wen; Zhu, Bo-Chao; Bing, Yuan-Hao; Zhang, Xiao-Xi; Lü, Chen

    2014-06-01

    The humus soils were collected from Betula platyphylla and Quercus liaotungensis pure plantations and woodless land separately where the site conditions were basically the same, and taken as medium for potting culture test of 9 kinds of shrubs or herbs in plastic greenhouse to assess the allelopathic effects of humus soils of pure plantations on shrubs or herbs. Humus soils from B. platyphylla plantation significantly inhibited the seed germinations of Medicago sativa and Melilotus officinalis, decreased the catalase (CAT) activity of M. officinalis, Coronilla varia, M. sativa and Lespedeza davurica, and improved malondialdehyde (MDA) contents in seedlings of Caragana kor-shinskii, C. varia and Astragalus adsurgens. The biomass growths of C. varia, Amorpha fruticosa, M. sativa, M. officinalis and A. adsurgens in humus soils from B. platyphylla plantation were significantly decreased by 48.2%, 45.1%, 44.3%, 37.3% and 36.0%, respectively. In addition, humus soil of Q. liaotungensis plantation significantly decreased the germination rates of M. sativa and A. adsurgens, the chlorophyll contents of Vicia villosa, A. fruticosa and M. sativa, and improved malondialdehyde (MDA) contents in seedlings of Lespedeza davurica, Caragana korshinskii, M. officinalis and A. adsurgens. The biomass growths of A. adsurgens, M. sativa, M. officinalis and A. fruticosa were significantly decreased by 52.6% , 43.8%, 35.5% and 34.6%, respective- ly. B. platyphylla plantation humus soil had obvious inhibition effects on M. sativa, M. officinalis and A. fruticosa, while Q. liaotungensis plantation humus soil had obvious inhibition effects on M. sativa, A. adsurgens and A. fruticosa.

  12. Mathematical Model for Multicomponent Adsorption Equilibria Using Only Pure Component Data

    DEFF Research Database (Denmark)

    Marcussen, Lis

    2000-01-01

    A mathematical model for nonideal adsorption equilibria in multicomponent mixtures is developed. It is applied with good results for pure substances and for prediction of strongly nonideal multicomponent equilibria using only pure component data. The model accounts for adsorbent...

  13. Dietary levels of pure flavonoids improve spatial memory performance and increase hippocampal brain-derived neurotrophic factor.

    Directory of Open Access Journals (Sweden)

    Catarina Rendeiro

    Full Text Available Evidence suggests that flavonoid-rich foods are capable of inducing improvements in memory and cognition in animals and humans. However, there is a lack of clarity concerning whether flavonoids are the causal agents in inducing such behavioral responses. Here we show that supplementation with pure anthocyanins or pure flavanols for 6 weeks, at levels similar to that found in blueberry (2% w/w, results in an enhancement of spatial memory in 18 month old rats. Pure flavanols and pure anthocyanins were observed to induce significant improvements in spatial working memory (p = 0.002 and p = 0.006 respectively, to a similar extent to that following blueberry supplementation (p = 0.002. These behavioral changes were paralleled by increases in hippocampal brain-derived neurotrophic factor (R = 0.46, p<0.01, suggesting a common mechanism for the enhancement of memory. However, unlike protein levels of BDNF, the regional enhancement of BDNF mRNA expression in the hippocampus appeared to be predominantly enhanced by anthocyanins. Our data support the claim that flavonoids are likely causal agents in mediating the cognitive effects of flavonoid-rich foods.

  14. General entanglement-assisted transformation for bipartite pure quantum states

    Science.gov (United States)

    Song, Wei; Huang, Yan; Nai-LeLiu; Chen, Zeng-Bing

    2007-01-01

    We introduce the general catalysts for pure entanglement transformations under local operations and classical communications in such a way that we disregard the profit and loss of entanglement of the catalysts per se. As such, the possibilities of pure entanglement transformations are greatly expanded. We also design an efficient algorithm to detect whether a k × k general catalyst exists for a given entanglement transformation. This algorithm can also be exploited to witness the existence of standard catalysts.

  15. The neuroanatomy of pure apraxia of speech in stroke.

    Science.gov (United States)

    Graff-Radford, Jonathan; Jones, David T; Strand, Edythe A; Rabinstein, Alejandro A; Duffy, Joseph R; Josephs, Keith A

    2014-02-01

    The left insula or Broca's area have been proposed as the neuroanatomical correlate for apraxia of speech (AOS) based on studies of patients with both AOS and aphasia due to stroke. Studies of neurodegenerative AOS suggest the premotor area and the supplementary motor areas as the anatomical correlates. The study objective was to determine the common infarction area in patients with pure AOS due to stroke. Patients with AOS and no or equivocal aphasia due to ischemic stroke were identified through a pre-existing database. Seven subjects were identified. Five had pure AOS, and two had equivocal aphasia. MRI lesion analysis revealed maximal overlap spanning the left premotor and motor cortices. While both neurodegenerative AOS and stroke induced pure AOS involve the premotor cortex, further studies are needed to establish whether stroke-induced AOS and neurodegenerative AOS share a common anatomic substrate. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. Pure Gravities via Color-Kinematics Duality for Fundamental Matter

    CERN Document Server

    Johansson, Henrik

    2015-01-01

    We give a prescription for the computation of loop-level scattering amplitudes in pure Einstein gravity, and four-dimensional pure supergravities, using the color-kinematics duality. Amplitudes are constructed using double copies of pure (super-)Yang-Mills parts and additional contributions from double copies of fundamental matter, which are treated as ghosts. The opposite-statistics states cancel the unwanted dilaton and axion in the bosonic theory, as well as the extra matter supermultiplets in supergravities. As a spinoff, we obtain a prescription for obtaining amplitudes in supergravities with arbitrary non-self-interacting matter. As a prerequisite, we extend the color-kinematics duality from the adjoint to the fundamental representation of the gauge group. We explain the numerator relations that the fundamental kinematic Lie algebra should satisfy. We give nontrivial evidence supporting our construction using explicit tree and loop amplitudes, as well as more general arguments.

  17. Visibility in a pure model of golden spiral phyllotaxis.

    Science.gov (United States)

    Herrmann, Burghard

    2018-07-01

    This paper considers the geometry of plants with golden spiral phyllotaxis, i.e. growing leaf by leaf on a spiral with golden divergence angle, via the simplest mathematical model, a cylinder with regular arrangement of points on its surface. As is well-known, Fibonacci numbers appear by means of the order of parastichies. This fact is shown to be a straightforward application of logical consequences to a particular model with respect to pure visibility. This notion is very similar to that of contact parastichies. The 3-D cylindrical model of golden spiral phyllotaxis abstracts from the form of leaves and identifies them with points. Pure visibility is specified in the 2-D representation so that common sense parastichies can be scrutinized. The main Theorem states that the orders of the purely most visible parastichies are Fibonacci numbers. Copyright © 2018 Elsevier Inc. All rights reserved.

  18. Perceptions of the Pure Pallet Program

    National Research Council Canada - National Science Library

    Dye, Michael T

    2006-01-01

    .... Recommendations center on educating personnel on the importance of suboptimization avoidance and making the warfighter the most important customer. This research also serves as a formal source of information from which to form conclusions and make judgments on how well Air Force personnel are implementing the pure pallet program.

  19. Detection of epistatic effects with logic regression and a classical linear regression model.

    Science.gov (United States)

    Malina, Magdalena; Ickstadt, Katja; Schwender, Holger; Posch, Martin; Bogdan, Małgorzata

    2014-02-01

    To locate multiple interacting quantitative trait loci (QTL) influencing a trait of interest within experimental populations, usually methods as the Cockerham's model are applied. Within this framework, interactions are understood as the part of the joined effect of several genes which cannot be explained as the sum of their additive effects. However, if a change in the phenotype (as disease) is caused by Boolean combinations of genotypes of several QTLs, this Cockerham's approach is often not capable to identify them properly. To detect such interactions more efficiently, we propose a logic regression framework. Even though with the logic regression approach a larger number of models has to be considered (requiring more stringent multiple testing correction) the efficient representation of higher order logic interactions in logic regression models leads to a significant increase of power to detect such interactions as compared to a Cockerham's approach. The increase in power is demonstrated analytically for a simple two-way interaction model and illustrated in more complex settings with simulation study and real data analysis.

  20. Effects of ionizing radiation on various core/clad ratio step index pure silica fibers

    International Nuclear Information System (INIS)

    Greenwell, R.A.; Barnes, C.E.; Nelson, G.W.

    1988-01-01

    Radiation testing was performed on polyimide-coated pure-silica-core step-index fibers fabricated from different preform core/clad ratios. Preliminary results indicate that the smaller the core/clad ratio, the better the radiation response of the fiber. These results are fortuitous for space applications, since the polyimide coating is also a low-outgassing wide-temperature-range small-size fiber coating material. The variations in radiation response may be due to a postdrawing anneal occurring during coating cure, which minimizes drawing-induced defects. 8 references

  1. An effective fitting scheme for the dynamic structure of pure liquids

    International Nuclear Information System (INIS)

    Wax, J-F; Bryk, Taras

    2013-01-01

    A scheme of analysis for the dynamic structure functions in pure liquids is presented which can be implemented with both experimental and simulation data. Expressions for contributions of relaxing and propagating modes proposed earlier in the framework of the generalized collective modes approach are optimized in order to strictly fulfil three among the required sum-rules. The method is applied to simulation data for liquid cesium, the description of which appears to only require one relaxing and one propagating mode in the investigated wavevector range. These expressions are able to account for the dynamics in both the hydrodynamic and the kinetic regimes, being quantitatively accurate up to the onset of the first peak of the static structure factor and qualitatively beyond. Features of the modes can thus be obtained easily, without resorting to heavy formalism. The scheme of analysis can be straightforwardly extended to account for a higher number of relaxing and propagating modes. (paper)

  2. Radiative heat transfer analysis in pure water heater used for semiconductor processing

    International Nuclear Information System (INIS)

    Liu, L.H.; Kudo, K.; Mochida, A.; Ogawa, T.; Kadotani, K.

    2004-01-01

    A simplified one-dimensional model is presented to analyze the non-gray radiative transfer in pure water heater used in the rinsing processes within semiconductor production lines, and the ray-tracing method is extended to simulate the radiative heat transfer. To examine the accuracy of the simplified model, the distribution of radiation absorption is determined by the ray-tracing method based the simplified model and compared with the data obtained by three-dimensional non-gray model in combination with Monte Carlo method in reference, and the effects of the water thickness on the radiation absorption are analyzed. The results show that the simplified model has a good accuracy in solving the radiation absorption in the pure water heater. The radiation absorption increases with the water thickness, but when the water thickness is greater than 50 mm, the radiation absorption increases very slowly with the water thickness

  3. The Mosaic Ancestry of the Drosophila Genetic Reference Panel and the D. melanogaster Reference Genome Reveals a Network of Epistatic Fitness Interactions.

    Science.gov (United States)

    Pool, John E

    2015-12-01

    North American populations of Drosophila melanogaster derive from both European and African source populations, but despite their importance for genetic research, patterns of ancestry along their genomes are largely undocumented. Here, I infer geographic ancestry along genomes of the Drosophila Genetic Reference Panel (DGRP) and the D. melanogaster reference genome, which may have implications for reference alignment, association mapping, and population genomic studies in Drosophila. Overall, the proportion of African ancestry was estimated to be 20% for the DGRP and 9% for the reference genome. Combining my estimate of admixture timing with historical records, I provide the first estimate of natural generation time for this species (approximately 15 generations per year). Ancestry levels were found to vary strikingly across the genome, with less African introgression on the X chromosome, in regions of high recombination, and at genes involved in specific processes (e.g., circadian rhythm). An important role for natural selection during the admixture process was further supported by evidence that many unlinked pairs of loci showed a deficiency of Africa-Europe allele combinations between them. Numerous epistatic fitness interactions may therefore exist between African and European genotypes, leading to ongoing selection against incompatible variants. By focusing on hubs in this network of fitness interactions, I identified a set of interacting loci that include genes with roles in sensation and neuropeptide/hormone reception. These findings suggest that admixed D. melanogaster samples could become an important study system for the genetics of early-stage isolation between populations. © The Author 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

  4. Subpopulation Treatment Effect Pattern Plot (STEPP) analysis of Ki67 assay according to histology: prognostic relevance for resected early stage 'pure' and 'mixed' lobular breast cancer.

    Science.gov (United States)

    Carbognin, Luisa; Sperduti, Isabella; Brunelli, Matteo; Marcolini, Lisa; Nortilli, Rolando; Pilotto, Sara; Zampiva, Ilaria; Merler, Sara; Fiorio, Elena; Filippi, Elisa; Manfrin, Erminia; Pellini, Francesca; Bonetti, Franco; Pollini, Giovanni Paolo; Tortora, Giampaolo; Bria, Emilio

    2016-03-22

    The aim of this analysis was to investigate the potential impact of Ki67 assay in a series of patients affected by early stage invasive lobular carcinoma (ILC) undergone surgery. Clinical-pathological data were correlated with disease-free and overall survival (DFS/OS). The maximally selected Log-Rank statistics analysis was applied to the Ki67 continuous variable to estimate appropriate cut-offs. The Subpopulation Treatment Effect Pattern Plot (STEPP) analysis was performed to assess the interaction between 'pure' or 'mixed' histology ILC and Ki67. At a median follow-up of 67 months, 10-years DFS and OS of 405 patients were 67.8 and 79.8%, respectively. Standardized Log-Rank statistics identified 2 optimal cut-offs (6 and 21%); 10-years DFS and OS were 75.1, 66.5, and 30.2% (p = 0.01) and 84.3, 76.4 and 59% (p = 0.003), for patients with a Ki67 21%, respectively. Ki67 and lymph-node status were independent predictor for longer DFS and OS at the multivariate analysis, with radiotherapy (for DFS) and age (for OS). Ki67 highly replicated at the internal cross-validation analysis (DFS 85%, OS 100%). The STEPP analysis showed that DFS rate decreases as Ki67 increases and those patients with 'pure' ILC performed worse than 'mixed' histology. Despite the retrospective and exploratory nature of the study, Ki67 was able to significantly discriminate the prognosis of patients with ILC, and the effect was more pronounced for patients with 'pure' ILC.

  5. Heat engine driven by purely quantum information.

    Science.gov (United States)

    Park, Jung Jun; Kim, Kang-Hwan; Sagawa, Takahiro; Kim, Sang Wook

    2013-12-06

    The key question of this Letter is whether work can be extracted from a heat engine by using purely quantum mechanical information. If the answer is yes, what is its mathematical formula? First, by using a bipartite memory we show that the work extractable from a heat engine is bounded not only by the free energy change and the sum of the entropy change of an individual memory but also by the change of quantum mutual information contained inside the memory. We then find that the engine can be driven by purely quantum information, expressed as the so-called quantum discord, forming a part of the quantum mutual information. To confirm it, as a physical example we present the Szilard engine containing a diatomic molecule with a semipermeable wall.

  6. Purely non-local Hamiltonian formalism, Kohno connections and ∨-systems

    International Nuclear Information System (INIS)

    Arsie, Alessandro; Lorenzoni, Paolo

    2014-01-01

    In this paper, we extend purely non-local Hamiltonian formalism to a class of Riemannian F-manifolds, without assumptions on the semisimplicity of the product ○ or on the flatness of the connection ∇. In the flat case, we show that the recurrence relations for the principal hierarchy can be re-interpreted using a local and purely non-local Hamiltonian operators and in this case they split into two Lenard-Magri chains, one involving the even terms, the other involving the odd terms. Furthermore, we give an elementary proof that the Kohno property and the ∨-system condition are equivalent under suitable assumptions and we show how to associate a purely non-local Hamiltonian structure to any ∨-system, including degenerate ones

  7. Brown bear sperm double freezing: Effect of elapsed time and use of PureSperm(®) gradient between freeze-thaw cycles.

    Science.gov (United States)

    Alvarez-Rodríguez, Manuel; Alvarez, Mercedes; López-Urueña, Elena; Martínez-Rodriguez, Carmen; Borragan, Santiago; Anel-López, Luis; de Paz, Paulino; Anel, Luis

    2013-12-01

    The use of sexed spermatozoa has great potential to captive population management in endangered wildlife. The problem is that the sex-sorting facility is a long distance from the semen collection place and to overcome this difficulty two freeze-thaw cycles may be necessary. In this study, effects of refreezing on brown bear electroejaculated spermatozoa were analyzed. We carried out two experiments: (1) to assess the effects of the two freezing-thawing cycles on sperm quality and to analyze three different elapsed times between freezing-thawing cycles (30, 90 and 180 min), and (2) to analyze the use of PureSperm between freezing-thawing cycles to select a more motile and viable sperm subpopulation which better survived first freezing. The motility, viability and undamaged acrosomes were significantly reduced after the second thawing respect to first thawing into each elapsed time group, but the elapsed times did not significantly affect the viability and acrosome status although motility was damaged. Our results with the PureSperm gradient showed higher values of viability in freezability of select sample (pellet) respect to the rest of the groups and it also showed a significant decrease in the number of acrosome damaged. In summary, the double freezing of bear semen selected by gradient centrifugation is qualitatively efficient, and thus could be useful to carry out a sex-sorting of frozen-thawed bear spermatozoa before to send the cryopreserved sample to a biobank. Given the low recovery of spermatozoa after applying a selection gradient, further studies will be needed to increase the recovery rate without damaging of the cell quality. Copyright © 2013 Elsevier Inc. All rights reserved.

  8. Effects of alloying elements (Mn, Co, Al, W, Sn, B, C and S) on biodegradability and in vitro biocompatibility of pure iron.

    Science.gov (United States)

    Liu, B; Zheng, Y F

    2011-03-01

    Pure iron was determined to be a valid candidate material for biodegradable metallic stents in recent animal tests; however, a much faster degradation rate in physiological environments was desired. C, Mn, Si, P, S, B, Cr, Ni, Pb, Mo, Al, Ti, Cu, Co, V and W are common alloying elements in industrial steels, with Cr, Ni, Mo, Cu, Ti, V and Si being acknowledged as beneficial in enhancing the corrosion resistance of iron. The purpose of the present work (using Fe-X binary alloy models) is to explore the effect of the remaining alloying elements (Mn, Co, Al, W, B, C and S) and one detrimental impurity element Sn on the biodegradability and biocompatibility of pure iron by scanning electron microscopy, X-ray diffraction, metallographic observation, tensile testing, microhardness testing, electrochemical testing, static (for 6 months) and dynamic (for 1 month with various dissolved oxygen concentrations) immersion testing, cytotoxicity testing, hemolysis and platelet adhesion testing. The results showed that the addition of all alloying elements except for Sn improved the mechanical properties of iron after rolling. Localized corrosion of Fe-X binary alloys was observed in both static and dynamic immersion tests. Except for the Fe-Mn alloy, which showed a significant decrease in corrosion rate, the other Fe-X binary alloy corrosion rates were close to that of pure iron. It was found that compared with pure iron all Fe-X binary alloys decreased the viability of the L929 cell line, none of experimental alloying elements significantly reduced the viability of vascular smooth muscle cells and all the elements except for Mn increased the viability of the ECV304 cell line. The hemolysis percentage of all Fe-X binary alloy models were less than 5%, and no sign of thrombogenicity was observed. In vitro corrosion and the biological behavior of these Fe-X binary alloys are discussed and a corresponding mechanism of corrosion of Fe-X binary alloys in Hank's solution proposed. As a

  9. Regional cerebral blood flow in pure dysarthria. A 3D-SSP study

    International Nuclear Information System (INIS)

    Okamoto, Kensho; Kamogawa, Kenji; Okuda, Bungo; Kawabata, Keita; Tachibana, Hisao

    2007-01-01

    Pure dysarthria from brain infarction is a rare condition, and its pathophysiology remains unclear. To clarify the underlying mechanism of pure dysarthria, we investigated the lesion sites and regional cerebral blood flow in patients with pure dysarthria. We examined 18 consecutive patients with pure dysarthria (9 men and 9 women; mean age, 71 years) who underwent MRI and cerebral blood flow studies. To visualize the regional cerebral blood flow, we generated Z score images using the three-dimensional stereotactic surface projection (3D-SSP) method with single-photon emission computed tomography (SPECT) and N-isopropyl-p [ 123 I]iodoamphetamine. Data on the brain surface perfusion extracted by the 3D-SSP analysis were compared between the pure dysarthria (PD) patients and 9 control subjects. MRI revealed multiple lacunar infarctions involving the internal capsule and/or corona radiata in 11 patients, left internal capsule-corona radiata infarction in 4 patients, and pontine infarction in 3 patients. SPECT with 3D-SSP demonstrated bilateral frontal cortical hypoperfusion in all patients, particularly in the anterior opercular region. Based on intergroup comparisons, the PD group exhibited pronounced cortical hypoperfusion in the opercular and medial frontal regions, left more than right. In conclusion, pure dysarthria is considered to originate from frontal cortical hypoperfusion, mainly in the anterior opercular and medial frontal regions, which is probably due to interruption of the corticosubcortical neural networks relevant to speech expression and articulation. In addition, it is suggested that left hemispheric lesions may make a greater contribution to the development of pure dysarthria than do right ones. (author)

  10. Effect of chitosan nanoparticles and pectin content on mechanical properties and water vapor permeability of banana puree films.

    Science.gov (United States)

    Martelli, Milena R; Barros, Taís T; de Moura, Márcia R; Mattoso, Luiz H C; Assis, Odilio B G

    2013-01-01

    Puree prepared from over-ripe peeled bananas was used as raw material for films processing in a laboratory padder. Pectin and glycerol as plasticizer were added in small concentrations and chitosan nanoparticles (88.79 ± 0.42 nm medium size) incorporated at 0.2% (dry weight basis) as reinforcement material. The mechanical properties, water vapor transmission, thermal stability, and scanning electron microscopy of fractured film surfaces were characterized. Both pectin and glycerol demonstrated an important role in promoting elongation and film handability as was expected. The incorporation of nanoparticles promoted noticeable improvement of the mechanical properties and acted in reducing the water vapor permeation rate, by 21% for films processed with pectin and up to 38% for films processed without pectin, when compared to the control (puree films with no pectin and nanoparticles additions). Microscopic observation revealed a denser matrix when nanoparticles are incorporated into the films. The development of films from fruit purees head to a new strategy for plastic processing from natural resources. The over-ripe or even waste banana can be adequately prepared for batch films processed with reasonable mechanical and barrier properties, suitable for applications in the food segment. The addition of small fractions of chitosan nanoparticles, form nanocomposites enhancing mechanical and thermal stability broadening potential film applications. © 2012 Institute of Food Technologists®

  11. Beneficial effects of oral pure caffeine on oxidative stress

    Directory of Open Access Journals (Sweden)

    Daniela Metro

    2017-12-01

    Full Text Available Ingestion of coffee (which is a mixture of over 1000 hydrosoluble substances is known to protect from type-2 diabetes mellitus and its complications, and other chronic disorders associated with increased oxidative damage in blood and tissues. This protection is generally attributed to polyphenols and melanoidins. Very few studies were conducted on the amelioration of classic blood markers of oxidative stress induced after a few days of caffeine administration, but results vary.To assess whether caffeine per se could account for antioxidant properties of coffee in the short-term, we tested the ability of pure caffeine ingestion (5 mg/kg body weight/day in two daily doses for seven consecutive days to improve plasma levels of six biochemical indices in healthy male volunteers (n = 15. These indices were total antioxidant capacity (TAC, glutathione (GSH, oxidized glutathione (GSSG, GSH to GSSG ratio, lipid hydroperoxides (LOOH and malondialdehyde (MDA.We found that all indices changed significantly (P < .05 or < .01 in a favourable manner, ranging from −41% for GSSG to −70% for LHP levels, and +106% for GSH levels to +249% for the GSG/GSSG ratio. Changes of any given index were uniform across subjects, with no outliers.We conclude that caffeine has unequivocal, consistent antioxidant properties. Keyword: Oxidative stress, Coffee, Caffeine, Lipid peroxidation, Gluthathione, Malondialdehyde

  12. Carbon nanotubes accelerate methane production in pure cultures of methanogens and in a syntrophic coculture

    NARCIS (Netherlands)

    Salvador, Andreia F.; Martins, Gilberto; Melle-Franco, Manuel; Serpa, Ricardo; Stams, Alfons J.M.; Cavaleiro, Ana J.; Pereira, M.A.; Alves, M.M.

    2017-01-01

    Carbon materials have been reported to facilitate direct interspecies electron transfer (DIET) between bacteria and methanogens improving methane production in anaerobic processes. In this work, the effect of increasing concentrations of carbon nanotubes (CNT) on the activity of pure cultures of

  13. Economic impacts associated with pure taxable capacity changes

    International Nuclear Information System (INIS)

    Bjornstad, D.J.

    1978-01-01

    An attempt is made to broaden the purview of fiscal impact analysis to include impacts on the local private sector that may stem from local public sector changes. More specifically, attention is focused on the limiting case, in which new private sector development yields positive changes in fiscal capacity, but does not increase public service demands or interact with the local private sector. This phenomenon is termed a ''pure'' change in fiscal capacity, or, stated differently, pure tax revenue importation. Interest in this issue stems from an analysis of the local impacts of constructing and operating nuclear power stations. Nuclear power stations, like other electrical generating facilities, are characterized by large capital-labor ratios, implying that the impact of siting would be to increase local taxable capacity, via the property tax base, to a greater extent than local private sector activity, via new hirings. Moreover, a small labor force implies a modest change in the demand for local public services, and facilities of this nature by themselves demand few, if any, public services. A nuclear power station, however, may be distinguished from other electrical generating facilities through siting regulations that require locating in a low population density area, a fact which ensures the influence on the community will be substantial. The question of how and to what degree feedback effects from local public to local private sector may take place is described

  14. Preparation of pure phenols from tars

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, J

    1929-06-18

    A process is disclosed for preparing pure phenols from brown coal and shale tar, characterized in that the alkaline extract obtained from the tar is oxidized and concurrently the alkaline solution is separated from the existing impurities by heating with steam at high temperature, which finally reaches at least 150/sup 0/C.

  15. Controlled synthesis of phase-pure zeolitic imidazolate framework Co-ZIF-9

    NARCIS (Netherlands)

    Öztürk, Z.; Hofmann, J.P.; Lutz, M.; Mazaj, M.; Zabukovec Logar, N.; Weckhuysen, B.M.

    2015-01-01

    The synthesis of phase-pure Co-ZIF-9, an important cobalt-based zeolitic imidazolate framework, could be achieved by modification of the reported synthesis procedure through pH adjustment of the starting synthesis mixture. The phase-pure Co-ZIF-9 material obtained has been characterized by a

  16. Effects of hydrostatic pressure on the excitation-emission matrix (EEM) of a series of pure PAHs

    International Nuclear Information System (INIS)

    Sun, Zhi-juan; Wang, Jie; Ye, Shu-ming; Jiang, Chun-yue; Chen, Hang

    2017-01-01

    The effects of hydrostatic pressure on the EEM of a series of pure PAHs (naphthalene, fluorene, phenanthrene, acenaphthene, fluoranthene, and anthracene) with three different concentrations (10 -6 mol L -1 , 10 -5 mol L -1 , and 10 -4 mol L -1 ) were investigated in a pressure range from 0.1 MPa to 60 MPa at room temperature. According to the EEM, 2 (naphthalene) to 12 (anthracene) fluorescence peaks were observed and the variation of EEM under high pressure were revealed by analyzing the fluorescence peaks positions and intensities with the increased hydrostatic pressure. It is found that fluorescence peak shifts were not detected in the compression, however, both the enhancement of intensity (e.g. naphthalene, 10 -6 mol L -1 , peak of 225/330 nm, relative fluorescence intensity increased by 0.594) and reduction of intensity (e.g. fluorene, 10 -6 mol L -1 , peak of 275/309 nm, relative fluorescence intensity decreased by 0.0966) were observed. Otherwise, the pressure effects were magnified when the concentration was increased (e.g. the relative fluorescence intensity of anthracene (peak of 380/425 nm) increased by 0.0165 (10 -6 mol L -1 ) and decreased by 0.479 (10 -6 mol L -1 ) when the pressure was elevated from 0.1 MPa to 60 MPa).

  17. Multimedia programming with pure data

    CERN Document Server

    Chung, Bryan

    2013-01-01

    A quick and comprehensive tutorial book for media designers to jump-start interactive multimedia production with computer graphics, digital audio, digital video, and interactivity, using the Pure Data graphical programming environment.An introductory book on multimedia programming for media artists/designers who like to work on interactivity in their projects, digital art/design students who like to learn the first multimedia programming technique, and audio-visual performers who like to customize their performance sets

  18. On the question of pure or applied research in developing countries

    International Nuclear Information System (INIS)

    Sioshansi, P.; Lodhi, A.S.; Payrovan, H.

    1977-01-01

    One particular approach to the question of pure versus applied research is discussed in this article. It is pointed out how a modest applied research project has been initiated in this laboratory and how this line of work has subsequently developed to include pure research in related areas

  19. Eco-Cities: Possible or Purely Utopian?

    Science.gov (United States)

    2009-12-01

    00-2009 to 00-00-2009 4. TITLE AND SUBTITLE Eco-Cities: Possible or Purely Utopian? 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT...2005, Disney modified their building plans for Hong Kong Disneyland by shifting the angle of the front gate by twelve degrees in order to abide by

  20. Pure and Oxidized Copper Materials as Potential Antimicrobial Surfaces for Spaceflight Activities

    Science.gov (United States)

    Hahn, C.; Hans, M.; Hein, C.; Mancinelli, R. L.; Mücklich, F.; Wirth, R.; Rettberg, P.; Hellweg, C. E.; Moeller, R.

    2017-12-01

    Microbial biofilms can lead to persistent infections and degrade a variety of materials, and they are notorious for their persistence and resistance to eradication. During long-duration space missions, microbial biofilms present a danger to crew health and spacecraft integrity. The use of antimicrobial surfaces provides an alternative strategy for inhibiting microbial growth and biofilm formation to conventional cleaning procedures and the use of disinfectants. Antimicrobial surfaces contain organic or inorganic compounds, such as antimicrobial peptides or copper and silver, that inhibit microbial growth. The efficacy of wetted oxidized copper layers and pure copper surfaces as antimicrobial agents was tested by applying cultures of Escherichia coli and Staphylococcus cohnii to these metallic surfaces. Stainless steel surfaces were used as non-inhibitory control surfaces. The production of reactive oxygen species and membrane damage increased rapidly within 1 h of exposure on pure copper surfaces, but the effect on cell survival was negligible even after 2 h of exposure. However, longer exposure times of up to 4 h led to a rapid decrease in cell survival, whereby the survival of cells was additionally dependent on the exposed cell density. Finally, the release of metal ions was determined to identify a possible correlation between copper ions in suspension and cell survival. These measurements indicated a steady increase of free copper ions, which were released indirectly by cells presumably through excreted complexing agents. These data indicate that the application of antimicrobial surfaces in spaceflight facilities could improve crew health and mitigate material damage caused by microbial contamination and biofilm formation. Furthermore, the results of this study indicate that cuprous oxide layers were superior to pure copper surfaces related to the antimicrobial effect and that cell density is a significant factor that influences the time dependence of

  1. Critical opalescence in the pure Coulomb system

    Energy Technology Data Exchange (ETDEWEB)

    Bobrov, V.B., E-mail: vic5907@mail.r [Joint Institute for High Temperatures, Russian Academy of Sciences, Izhorskaia St., 13, Bd. 2. Moscow 125412 (Russian Federation); Trigger, S.A., E-mail: satron@mail.r [Joint Institute for High Temperatures, Russian Academy of Sciences, Izhorskaia St., 13, Bd. 2. Moscow 125412 (Russian Federation); Institut fuer Physik, Humboldt-Universitaet zu Berlin, Newtonstrasse 15, D-12489 Berlin (Germany)

    2011-04-18

    Highlights: The review of the critical opalescence problem is presented. Light scattering in a two-component electron-nuclear system is studied. The exact relations between the structure factors and compressibility are found. The obtained relations are valid for strong interaction for the Coulomb systems. The experimental verification of these relations is possible for various elements. - Abstract: Based on the dielectric formalism and quantum field theory methods, the phenomenon of critical opalescence is explained for light scattering in pure matter as a two-component electron-nuclear system with Coulomb interaction. A similar phenomenon is shown to occur in the case of neutron scattering in pure substances as well. The obtained results are valid for quantum case and arbitrary strong Coulomb interaction. Thus, the relations between structure factors derived for the electron-nuclear system are the exact result of the quantum statistical mechanics.

  2. (Invited) Pure Dopant Deposition of B and Ga for Ultrashallow Junctions in Si-based Devices

    NARCIS (Netherlands)

    Nanver, L.K.; Sammak, A.; Mohammadi, V.; Mok, K.R.C.; Qi, L.; Sakic, A.; Golshani, N.; Darakhshandeh, J.; Scholtes, T.M.L.; De Boer, W.B.

    2012-01-01

    Envisioning wide future relevance, work is reviewed here on the pure dopant deposition of boron (PureB), gallium (PureGa) and the combination of the two (PureGaB), as used in the fabrication of nanometer shallow p+n Si and/or Ge diodes. Focus is placed on the special properties that have put these

  3. Minimizing quality changes of cloudy apple juice: The use of kiwifruit puree and high pressure homogenization.

    Science.gov (United States)

    Yi, Junjie; Kebede, Biniam; Kristiani, Kristiani; Grauwet, Tara; Van Loey, Ann; Hendrickx, Marc

    2018-05-30

    Cloud loss, enzymatic browning, and flavor changes are important quality defects of cloudy fruit juices determining consumer acceptability. The development of clean label options to overcome such quality problems is currently of high interest. Therefore, this study investigated the effect of kiwifruit puree (clean label ingredient) and high pressure homogenization on quality changes of cloudy apple juice using a multivariate approach. The use of kiwifruit puree addition and high pressure homogenization resulted in a juice with improved uniformity and cloud stability by reducing particle size and increasing viscosity and yield stress (p < 0.01). Furthermore, kiwifruit puree addition reduced enzymatic browning (ΔE ∗  < 3), due to the increased ascorbic acid and contributed to a more saturated and bright yellow color, a better taste balance, and a more fruity aroma of juice. This work demonstrates that clean label options to control quality degradation of cloudy fruit juice might offer new opportunities. Copyright © 2018 Elsevier Ltd. All rights reserved.

  4. Transgastric pure-NOTES peritoneoscopy and endoscopic ultrasonography for staging of gastrointestinal cancers

    DEFF Research Database (Denmark)

    Donatsky, Anders Meller; Vilmann, Peter; Meisner, Søren

    2012-01-01

    BACKGROUND: Human natural orifice transluminal endoscopic surgery (NOTES) has mainly been based on simultaneous laparoscopic assistance (hybrid NOTES), forgoing the theoretical benefits of the NOTES technique. This is due to a lack of NOTES-specific instruments and endoscopes, making pure-NOTES...... procedures difficult and time consuming. An area where pure NOTES could be adopted at its present stage of development is minimally invasive staging of gastrointestinal (GI) cancer. The aim of this study is to evaluate the feasibility of combining transgastric (TG) pure-NOTES peritoneoscopy...... and intraperitoneal endoscopic ultrasonography (ip-EUS) with intraluminal EUS (il-EUS) for peritoneal evaluation. METHODS: This was a feasibility and survival study where il-EUS followed by ip-EUS and peritoneoscopy was performed in 10 pigs subjected to TG pure NOTES. A score was given with regard to achieved...

  5. Investigation of polar and stereoelectronic effects on pure excited-state hydrogen atom abstractions from phenols and alkylbenzenes.

    Science.gov (United States)

    Pischel, Uwe; Patra, Digambara; Koner, Apurba L; Nau, Werner M

    2006-01-01

    The fluorescence quenching of singlet-excited 2,3-diazabicyclo[2.2.2]oct-2-ene (DBO) by 22 phenols and 12 alkylbenzenes has been investigated. Quenching rate constants in acetonitrile are in the range of 10(8)-10(9) M(-1)s(-1) for phenols and 10(5)-10(6) M(-1)s(-1) for alkylbenzenes. In contrast to the quenching of triplet-excited benzophenone, no exciplexes are involved, so that a pure hydrogen atom transfer is proposed as quenching mechanism. This is supported by (1) pronounced deuterium isotope effects (kH/kD ca 4-6), which were observed for phenols and alkylbenzenes, and (2) a strongly endergonic thermodynamics for charge transfer processes (electron transfer, exciplex formation). In the case of phenols, linear free energy relationships applied, which led to a reaction constant of rho = -0.40, suggesting a lower electrophilicity of singlet-excited DBO than that of triplet-excited ketones and alkoxyl radicals. The reactivity of singlet-excited DBO exposes statistical, steric, polar and stereoelectronic effects on the hydrogen atom abstraction process in the absence of complications because of competitive exciplex formation.

  6. The b ghost of the pure spinor formalism is nilpotent

    Energy Technology Data Exchange (ETDEWEB)

    Chandia, Osvaldo, E-mail: osvaldo.chandia@uai.c [Departamento de Ciencias, Facultad de Artes Liberales and Facultad de Ingenieria y Ciencias, Universidad Adolfo Ibanez, Santiago (Chile)

    2011-01-10

    The ghost for world-sheet reparametrization invariance is not a fundamental field in the pure spinor formalism. It is written as a combination of pure spinor variables which have conformal dimension two and such that it commutes with the BRST operator to give the world-sheet stress tensor. We show that the ghost variable defined in this way is nilpotent since the OPE of b with itself does not have singularities.

  7. Model answers in pure mathematics for a-level students

    CERN Document Server

    Pratt, GA; Schofield, C W

    1967-01-01

    Model Answers in Pure Mathematics for A-Level Students provides a set of solutions that indicate what is required and expected in an Advanced Level examination in Pure Mathematics. This book serves as a guide to the length of answer required, layout of the solution, and methods of selecting the best approach to any particular type of math problem. This compilation intends to supplement, not replace, the normal textbook and provides a varied selection of questions for practice in addition to the worked solutions. The subjects covered in this text include algebra, trigonometry, coordinate geomet

  8. Bayero Journal of Pure and Applied Sciences

    African Journals Online (AJOL)

    The Journal's scope is wide in that it reported findings in the areas of pure and ... Physics, Medical Sciences and Zoology form part of the contents of the Journal. Scientists in the academia, research institutes and industries are therefore ...

  9. Purely Magnetic Silent Universes do not Exist

    Science.gov (United States)

    Vu, K. T.; Carminati, J.

    2008-09-01

    We present a new Maple package called STeM (Symbolic Tetrad Manipulation). Using STeM, we outline, using a formalism which is a hybrid of the NP and Orthonormal ones, the proof of the nonexistence of purely magnetic silent universes.

  10. Pure General Gauge Mediation for Early LHC Searches

    CERN Document Server

    Abel, Steven; Jaeckel, Joerg; Khoze, Valentin V

    2010-01-01

    We present benchmark points for Pure General Gauge Mediation (GGM) models specifically optimised for early LHC searches. The pure GGM set-up is as defined in our previous paper arXiv:0910.2674: namely we adopt the minimal set-up in which B_mu is generated only through gauge interactions, and as a result tan beta is a prediction rather than an input. The only input parameters are messenger masses together with two independent scales which generate gaugino and scalar masses. The parameter space favoured by current experimental data includes an interesting region with light gluinos (m_g 2 cross-sections. This data in SLHA format can be found at http://www.ippp.dur.ac.uk/~SUSY

  11. Lattice modes of the chirally pure and racemic phases of tyrosine crystals

    Energy Technology Data Exchange (ETDEWEB)

    Belyanchikov, M. A. [Moscow Institute of Physics and Technology (Russian Federation); Gorelik, V. S., E-mail: gorelik@sci.lebedev.ru [Russian Academy of Sciences, Lebedev Physical Institute (Russian Federation); Gorshunov, B. P. [Moscow Institute of Physics and Technology (Russian Federation); Pyatyshev, A. Yu., E-mail: jb-valensia@mail.ru [Bauman Moscow State Technical University (Russian Federation)

    2017-01-15

    High-Q librational modes have been found to be present in the infrared absorption and Raman spectra of chirally pure L-tyrosine. Such modes can serve as terahertz radiation detectors and generators in chirally pure biostructures.

  12. Pure sociology and social geometry as an example of formal sociological theory

    Directory of Open Access Journals (Sweden)

    Škorić Marko

    2012-01-01

    Full Text Available This paper analyzes pure sociology and social geometry of Donald Black as an example of formal sociological theory. Starting with the importance of formal and analytical theory in sociology, we present the bold theoretical strategy and/or the paradigm of the sociology of behavior of social life. The examples of pure sociology and social geometry concerning law, violence and homosexuality are presented as well. A review and critique of pure sociology as a scientific formal theory is offered in the end.

  13. Effects of Improving Primary Health Care Workers' Knowledge About Public Health Services in Rural China: A Comparative Study of Blended Learning and Pure E-Learning.

    Science.gov (United States)

    Zhan, Xingxin; Zhang, Zhixia; Sun, Fang; Liu, Qian; Peng, Weijun; Zhang, Heng; Yan, Weirong

    2017-05-01

    Primary health care workers (PHCWs) are a major force in delivering basic public health services (BPHS) in rural China. It is necessary to take effective training approaches to improve PHCWs' competency on BPHS. Both electronic learning (e-learning) and blended learning have been widely used in the health workers' education. However, there is limited evidence on the effects of blended learning in comparison with pure e-learning. The aim of this study was to evaluate the effects of a blended-learning approach for rural PHCWs in improving their knowledge about BPHS as well as training satisfaction in comparison with a pure e-learning approach. The study was conducted among PHCWs in 6 rural counties of Hubei Province, China, between August 2013 and April 2014. Three counties were randomly allocated blended-learning courses (29 township centers or 612 PHCWs-the experimental group), and three counties were allocated pure e-learning courses (31 township centers or 625 PHCWs-the control group). Three course modules were administered for 5 weeks, with assessments at baseline and postcourse. Primary outcomes were score changes in courses' knowledge. Secondary outcome was participant satisfaction (5-point Likert scale anchored between 1 [strongly agree] and 5 [strongly disagree]). The experimental group had higher mean scores than the control group in knowledge achievement in three course modules: (1) module 1: 93.21 (95% CI 92.49-93.93) in experimental group versus 88.29 (95% CI 87.19-89.40) in the control group; adjusted difference, 4.92 (95% CI 2.61-7.24; Plearning group gave more positive responses with the four issues than control group participants: (1) the increase of interest in learning, 1.85 (95% CI 1.22-2.80; P=.003); (2) the increase of interaction with others, 1.77 (95% CI 1.20-2.60; P=.004); (3) the satisfaction with learning experience, 1.78 (95% CI 1.11-2.88; P=.02); and (4) achievement of learning objectives, 1.63 (95% CI 1.08-2.48; P=.02). Among PHCWs in

  14. In vitro degradation of pure Mg in response to glucose

    Science.gov (United States)

    Zeng, Rong-Chang; Li, Xiao-Ting; Li, Shuo-Qi; Zhang, Fen; Han, En-Hou

    2015-08-01

    Magnesium and its alloys are promising biodegradable biomaterials but are still challenging to be used in person with high levels of blood glucose or diabetes. To date, the influence of glucose on magnesium degradation has not yet been elucidated, this issue requires more attention. Herein, we present pure Mg exhibiting different corrosion responses to saline and Hank’s solutions with different glucose contents, and the degradation mechanism of pure Mg in the saline solution with glucose in comparison with mannitol as a control. On one hand, the corrosion rate of pure Mg increases with the glucose concentration in saline solutions. Glucose rapidly transforms into gluconic acid, which attacks the oxides of the metal and decreases the pH of the solution; it also promotes the absorption of chloride ions on the Mg surface and consequently accelerates corrosion. On the other hand, better corrosion resistance is obtained with increasing glucose content in Hank’s solution due to the fact that glucose coordinates Ca2+ ions in Hank’s solution and thus improves the formation of Ca-P compounds on the pure Mg surface. This finding will open up new avenues for research on the biodegradation of bio-Mg materials in general, which could yield many new and interesting results.

  15. QTL Information Table: 87 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available n effects, epistatic effects and environmental interactions of QTLs on the cooking and eating quality of rice in a doubled-haploid line population. Theor Appl Genet 110, 1445-1452. ...

  16. Too Little, Too Late: Reduced Visual Span and Speed Characterize Pure Alexia

    Science.gov (United States)

    Habekost, Thomas; Leff, Alexander P.

    2009-01-01

    Whether normal word reading includes a stage of visual processing selectively dedicated to word or letter recognition is highly debated. Characterizing pure alexia, a seemingly selective disorder of reading, has been central to this debate. Two main theories claim either that 1) Pure alexia is caused by damage to a reading specific brain region in the left fusiform gyrus or 2) Pure alexia results from a general visual impairment that may particularly affect simultaneous processing of multiple items. We tested these competing theories in 4 patients with pure alexia using sensitive psychophysical measures and mathematical modeling. Recognition of single letters and digits in the central visual field was impaired in all patients. Visual apprehension span was also reduced for both letters and digits in all patients. The only cortical region lesioned across all 4 patients was the left fusiform gyrus, indicating that this region subserves a function broader than letter or word identification. We suggest that a seemingly pure disorder of reading can arise due to a general reduction of visual speed and span, and explain why this has a disproportionate impact on word reading while recognition of other visual stimuli are less obviously affected. PMID:19366870

  17. Optical characterization of pure vegetable oils and their biodiesels using Raman spectroscopy

    Science.gov (United States)

    Firdous, S.; Anwar, S.; Waheed, A.; Maraj, M.

    2016-04-01

    Great concern regarding energy resources and environmental polution has increased interest in the study of alternative sources of energy. Biodiesels as an alternative fuel provide a suitable diesel oil substitute for internal combustion engines. The Raman spectra of pure biodiesels of soybean oil, olive oil, coconut oil, animal fats, and petroleum diesel are optically characterized for quality and biofuel as an alternative fuel. The most significant spectral differences are observed in the frequency range around 1457 cm-1 for pure petroleum diesel, 1427 for fats biodiesel, 1670 cm-1 for pure soybean oil, 1461 cm-1 for soybean oil based biodiesel, 1670 cm-1 for pure olive oil, 1666 cm-1 for olive oil based biodiesel, 1461 cm-1 for pure coconut oil, and 1460 cm-1 for coconut oil based biodiesel, which is used for the analysis of the phase composition of oils. A diode pump solid-state laser with a 532 nm wavelength is used as an illuminating light. It is demonstrated that the peak positions and relative intensities of the vibrations of the oils can be used to identify the biodiesel quality for being used as biofuel.

  18. Influence of dynamic compressive loading on the in vitro degradation behavior of pure PLA and Mg/PLA composite.

    Science.gov (United States)

    Li, Xuan; Qi, Chenxi; Han, Linyuan; Chu, Chenglin; Bai, Jing; Guo, Chao; Xue, Feng; Shen, Baolong; Chu, Paul K

    2017-12-01

    The effects of dynamic compressive loading on the in vitro degradation behavior of pure poly-lactic acid (PLA) and PLA-based composite unidirectionally reinforced with micro-arc oxidized magnesium alloy wires (Mg/PLA) are investigated. Dynamic compressive loading is shown to accelerate degradation of pure PLA and Mg/PLA. As the applied stress is increased from 0.1MPa to 0.9MPa or frequency from 0.5Hz to 2.5Hz, the overall degradation rate goes up. After immersion for 21days at 0.9MPa and 2.5Hz, the bending strength retention of the composite and pure PLA is 60.1% and 50%, respectively. Dynamic loading enhances diffusion of small acidic molecules resulting in significant pH decrease in the immersion solution. The synergistic reaction between magnesium alloy wires and PLA in the composite is further clarified by electrochemical tests. The degradation behavior of the pure PLA and PLA matrix in the composite under dynamic conditions obey the first order degradation kinetics and a numerical model is postulated to elucidate the relationship of the bending strength, stress, frequency, and immersion time under dynamic conditions. We systematically study the influence of dynamic loading on the degradation behavior of pure PLA and Mg/PLA. Dynamic compressive loading is shown to accelerate degradation of pure PLA and Mg/PLA. The synergistic reaction between magnesium alloy wires and PLA in the composite is firstly clarified by electrochemical tests. The degradation behavior of the pure PLA and PLA matrix in the composite under dynamic conditions obey the first order degradation kinetics. Then, a numerical model is postulated to elucidate the relationship of the bending strength, stress, frequency, and immersion time under dynamic conditions. Copyright © 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

  19. Pure states of general quantum-mechanical systems as Kaehler bundles

    International Nuclear Information System (INIS)

    Abbati, M.C.; Cirelli, R.; Lanzavecchia, P.; Mania, A.

    1984-01-01

    Pure states of general quantum systems in the Csup(*)-algebraic approach are endowed with a structure both of Kaehler manifold and of projective bundle with uniformity on the total space. The former structure gives a geometric interpretation of transition probabilities and Wigner theorem. The latter is a finer structure which determines Csup(*)-algebras up to sup(*)-isomorphisms. Pure states of Csup(*)-algebras with continuous trace among projective bundles with uniformity are characterized

  20. Decoherence and thermalization of a pure quantum state in quantum field theory.

    Science.gov (United States)

    Giraud, Alexandre; Serreau, Julien

    2010-06-11

    We study the real-time evolution of a self-interacting O(N) scalar field initially prepared in a pure, coherent quantum state. We present a complete solution of the nonequilibrium quantum dynamics from a 1/N expansion of the two-particle-irreducible effective action at next-to-leading order, which includes scattering and memory effects. We demonstrate that, restricting one's attention (or ability to measure) to a subset of the infinite hierarchy of correlation functions, one observes an effective loss of purity or coherence and, on longer time scales, thermalization. We point out that the physics of decoherence is well described by classical statistical field theory.

  1. Purely temporal figure-ground segregation.

    Science.gov (United States)

    Kandil, F I; Fahle, M

    2001-05-01

    Visual figure-ground segregation is achieved by exploiting differences in features such as luminance, colour, motion or presentation time between a figure and its surround. Here we determine the shortest delay times required for figure-ground segregation based on purely temporal features. Previous studies usually employed stimulus onset asynchronies between figure- and ground-containing possible artefacts based on apparent motion cues or on luminance differences. Our stimuli systematically avoid these artefacts by constantly showing 20 x 20 'colons' that flip by 90 degrees around their midpoints at constant time intervals. Colons constituting the background flip in-phase whereas those constituting the target flip with a phase delay. We tested the impact of frequency modulation and phase reduction on target detection. Younger subjects performed well above chance even at temporal delays as short as 13 ms, whilst older subjects required up to three times longer delays in some conditions. Figure-ground segregation can rely on purely temporal delays down to around 10 ms even in the absence of luminance and motion artefacts, indicating a temporal precision of cortical information processing almost an order of magnitude lower than the one required for some models of feature binding in the visual cortex [e.g. Singer, W. (1999), Curr. Opin. Neurobiol., 9, 189-194]. Hence, in our experiment, observers are unable to use temporal stimulus features with the precision required for these models.

  2. Critical opalescence in the pure Coulomb system

    International Nuclear Information System (INIS)

    Bobrov, V.B.; Trigger, S.A.

    2011-01-01

    Highlights: → The review of the critical opalescence problem is presented. → Light scattering in a two-component electron-nuclear system is studied. → The exact relations between the structure factors and compressibility are found. → The obtained relations are valid for strong interaction for the Coulomb systems. → The experimental verification of these relations is possible for various elements. - Abstract: Based on the dielectric formalism and quantum field theory methods, the phenomenon of critical opalescence is explained for light scattering in pure matter as a two-component electron-nuclear system with Coulomb interaction. A similar phenomenon is shown to occur in the case of neutron scattering in pure substances as well. The obtained results are valid for quantum case and arbitrary strong Coulomb interaction. Thus, the relations between structure factors derived for the electron-nuclear system are the exact result of the quantum statistical mechanics.

  3. Effect of solute atoms on swelling in Ni alloys and pure Ni under He + ion irradiation

    Science.gov (United States)

    Wakai, E.; Ezawa, T.; Imamura, J.; Takenaka, T.; Tanabe, T.; Oshima, R.

    2002-12-01

    The effects of solute atoms on microstructural evolutions have been investigated using Ni alloys under 25 keV He + irradiation at 500 °C. The specimens used were pure Ni, Ni-Si, Ni-Co, Ni-Cu, Ni-Mn and Ni-Pd alloys with different volume size factors. The high number densities of dislocation loops about 1.5×10 22 m -3 were formed in the specimens irradiated to 1×10 19 ions/m 2, and they were approximately equivalent, except for Ni-Si. The mean size of loops tended to increase with the volume size factor of solute atoms. In a dose of 4×10 20 ions/m 2, the swelling was changed from 0.2% to 4.5%, depending on the volume size factors. The number densities of bubbles tended to increase with the absolute values of the volume size factor, and the swelling increased with the volume size factors. This suggests that the mobility of helium and vacancy atoms may be influenced by the interaction of solute atoms with them.

  4. Effect of Laser Power and Scan Speed on Melt Pool Characteristics of Commercially Pure Titanium (CP-Ti)

    Science.gov (United States)

    Kusuma, Chandrakanth; Ahmed, Sazzad H.; Mian, Ahsan; Srinivasan, Raghavan

    2017-07-01

    Selective laser melting (SLM) is an additive manufacturing technique that creates complex parts by selectively melting metal powder layer-by-layer using a laser. In SLM, the process parameters decide the quality of the fabricated component. In this study, single beads of commercially pure titanium (CP-Ti) were melted on a substrate of the same material using an in-house built SLM machine. Multiple combinations of laser power and scan speed were used for single bead fabrication, while the laser beam diameter and powder layer thickness were kept constant. This experimental study investigated the influence of laser power, scan speed, and laser energy density on the melt pool formation, surface morphology, geometry (width and height), and hardness of solidified beads. In addition, the observed unfavorable effect such as inconsistency in melt pool width formation is discussed. The results show that the quality, geometry, and hardness of solidified melt pool are significantly affected by laser power, scanning speed, and laser energy density.

  5. Epistasis can accelerate adaptive diversification in haploid asexual populations.

    Science.gov (United States)

    Griswold, Cortland K

    2015-03-07

    A fundamental goal of the biological sciences is to determine processes that facilitate the evolution of diversity. These processes can be separated into ecological, physiological, developmental and genetic. An ecological process that facilitates diversification is frequency-dependent selection caused by competition. Models of frequency-dependent adaptive diversification have generally assumed a genetic basis of phenotype that is non-epistatic. Here, we present a model that indicates diversification is accelerated by an epistatic basis of phenotype in combination with a competition model that invokes frequency-dependent selection. Our model makes use of a genealogical model of epistasis and insights into the effects of balancing selection on the genealogical structure of a population to understand how epistasis can facilitate diversification. The finding that epistasis facilitates diversification may be informative with respect to empirical results that indicate an epistatic basis of phenotype in experimental bacterial populations that experienced adaptive diversification. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

  6. Fourier-transform ghost imaging with pure far-field correlated thermal light

    International Nuclear Information System (INIS)

    Liu Honglin; Shen Xia; Han Shensheng; Zhu Daming

    2007-01-01

    Pure far-field correlated thermal light beams are created with phase grating, and Fourier-transform ghost imaging depending only on the far-field correlation is demonstrated experimentally. Theoretical analysis and the results of experimental investigation of this pure far-field correlated thermal light are presented. Applications which may be exploited with this imaging scheme are discussed

  7. From word superiority to word inferiority: Visual processing of letters and words in pure alexia

    DEFF Research Database (Denmark)

    Habekost, Thomas; Petersen, Anders; Behrmann, Marlene

    2014-01-01

    Visual processing and naming of individual letters and short words were investigated in four patients with pure alexia. To test processing at different levels, the same stimuli were studied across a naming task and a visual perception task. The normal word superiority effect was eliminated in bot...

  8. Zeolite scaffolds for cultures of human breast cancer cells. Part II: Effect of pure and hybrid zeolite membranes on neoplastic and metastatic activity control.

    Science.gov (United States)

    Tavolaro, Palmira; Martino, Guglielmo; Andò, Sebastiano; Tavolaro, Adalgisa

    2016-11-01

    This work is focused on the response of two invasive phenotypes of human breast cancer cells, MCF-7 and MDA-MB-231, grown on synthesized zeolite scaffolds in order to study the influence of those biomaterials in controlled conditions with and without anti-tumoral drug treatments. Our research was directed to the use of doxorubicin (DOX) and bergapten (5-MOP). The former is broadly considered the most active single agent available for the treatment of breast cancer, the second is a natural psoralen with an apoptotic effect. The results indicate that both drugs inhibit the cell viability of all cell lines grown on all zeolite scaffolds and that all Pure Zeolite Membranes are more responsive with respect to all Mixed Matrix Membranes. Moreover, the results after treatment with DOX at a concentration of 7.4μM for 24h, show that the expression of the matrix metalloproteinases (MMP-2 and MMP-9) is greatly reduced in both cell lines, especially in those adherent on Pure Zeolite Scaffolds. Copyright © 2016 Elsevier B.V. All rights reserved.

  9. PET imaging with the non-pure positron emitters: 55Co, 86Y and 124I

    DEFF Research Database (Denmark)

    Braad, Poul-Erik; Hansen, S B; Thisgaard, H

    2015-01-01

    PET/CT with non-pure positron emitters is a highly valuable tool in immuno-PET and for pretherapeutic dosimetry. However, imaging is complicated by prompt gamma coincidences (PGCs) that add an undesired background activity to the images. Time-of-flight (TOF) reconstruction improves lesion...... detectability in 18F-PET and can potentially also improve the signal-to-noise ratio in images acquired with non-pure positron emitters. Using the GE Discovery 690 PET/CT system, we evaluated the image quality with 55Co, 86Y and 124I, and the effect of PGC-correction and TOF-reconstruction on image quality...... and quantitation in a series of phantom studies. PET image quality and quantitation for all isotopes were significantly affected by PGCs. The effect was most severe with 86Y, and less, but comparable, with 55Co and 124I. PGC-correction improved the image quality and the quantitation accuracy dramatically for all...

  10. Is word recognition crowded in pure alexia?

    DEFF Research Database (Denmark)

    Sand, Katrine; Habekost, Thomas; Petersen, Anders

    2017-01-01

    Pure alexia is a selective deficit in reading, which arises following damage to the left ventral occipito-temporal cortex. Crowding, the inability to recognise objects in a clutter, has recently been hypothesised to be the underlying deficit of apperceptive visual agnosia1. Crowding normally occurs...

  11. Angels and demons are among us: assessing individual differences in belief in pure evil and belief in pure good.

    Science.gov (United States)

    Webster, Russell J; Saucier, Donald A

    2013-11-01

    We conducted five studies to demonstrate that individuals' beliefs in pure evil (BPE) and in pure good (BPG) are valid and important psychological constructs. First, these studies together demonstrated that BPE and BPG are reliable, unitary, and stable constructs each composed of eight theoretically interdependent dimensions. Second, these studies showed that across a wide variety of different measures, higher BPE consistently related to greater intergroup aggression (e.g., supporting the death penalty and preemptive military aggression) and less intergroup prosociality (e.g., opposing criminal rehabilitation, proracial policies, and beneficial social programs), while higher BPG consistently related to less intergroup aggression (e.g., opposing proviolent foreign relations and torture) and greater intergroup prosociality (e.g., supporting criminal rehabilitation and support for diplomacy). In sum, these studies evidence that BPE and BPG relate to aggressive and prosocial orientations toward others and have strong potential to advance current theories on prejudice, aggression, and prosociality.

  12. An apparatus for preparing isotopically pure He4

    International Nuclear Information System (INIS)

    McClintock, P.V.E.

    1978-01-01

    A cryostat has been constructed for extracting pure He 4 from He II of natural isotopic composition by means of a heat flush technique. It is shown that the method is in principle capable of yielding He 4 which is entirely devoid of He 3 isotopic impurities. A secondary heat flush, operated in conjunction with a conical heat exchanger of novel design, was used to place an experimental lower bound of 2 x 10 15 on the He 4 /He 3 ratio of the product, a standard sufficient for all present or projected applications requiring isotopically pure He 4 . The apparatus produces 2 000 1 (at standard temperature and pressure) of He 4 per thermal cycle. The design of future purifiers is discussed. (author)

  13. Anodic oxidation of InP in pure water

    International Nuclear Information System (INIS)

    Robach, Y.; Joseph, J.; Bergignat, E.; Hollinger, G.

    1989-01-01

    It is shown that thin InP native oxide films can be grown by anodization of InP in pure water. An interfacial phosphorus-rich In(PO 3 ) 3 -like condensed phosphate is obtained this way. This condensed phosphate has good passivating properties and can be used in electronic device technology. The chemical composition of these native oxides was found similar to that of an anodic oxide grown in an anodization in glycol and water (AGW) electrolyte. From the similarity between the two depth profiles observed in pure water and AGW electrolyte, they can conclude that dissolution phenomena do not seem to play a major role. The oxide growth seems to be controlled by the drift of ionic species under the electric field

  14. Synthesis and characterization of nano- and microcrystalline cubes of pure and Ag-doped LiF

    Science.gov (United States)

    Alharbi, Najlaa D.; Salah, Numan; Habib, Sami S.; Alarfaj, Esam

    2013-01-01

    Lithium fluoride (LiF) produced in single crystals and doped with proper activators is a highly sensitive phosphor used in several applications such as integrated optics, colour centre laser and radiation dosimetry. In this work, we have developed a new synthetic chemical co-precipitation route for the synthesis of well-crystallized micro- and nanocrystalline cubes of pure and silver (Ag)-doped LiF. The as-synthesized samples were characterized by x-ray diffraction (XRD), scanning electron microscopy, absorption spectrum, photoluminescence (PL) and Raman spectroscopy. Size of the produced cubes could be controlled in the range 10 µm-50 nm by varying the solvent : co-solvent ratio. Micro-sized cubes could be grown in the presence of water as a solvent, while ethanol, which acts as a co-solvent, is found to be effective in reducing the size to the nanoscale. XRD results show complete crystalline structures in a griceite phase. The PL result of pure nanocubes exhibits a broad band in the range 370-550 nm, while that doped with Ag shows a prominent band at 420 nm. Raman spectra of the pure and Ag-doped LiF samples display several bands located in the range 80-236 cm-1. These results show that pure nanocubes of LiF have active colour centres without irradiation, which could be enhanced/modified by Ag dopants. This implies that these nanocubes might be useful in the development of optical devices.

  15. Synthesis and characterization of nano- and microcrystalline cubes of pure and Ag-doped LiF

    International Nuclear Information System (INIS)

    Alharbi, Najlaa D; Salah, Numan; Habib, Sami S; Alarfaj, Esam

    2013-01-01

    Lithium fluoride (LiF) produced in single crystals and doped with proper activators is a highly sensitive phosphor used in several applications such as integrated optics, colour centre laser and radiation dosimetry. In this work, we have developed a new synthetic chemical co-precipitation route for the synthesis of well-crystallized micro- and nanocrystalline cubes of pure and silver (Ag)-doped LiF. The as-synthesized samples were characterized by x-ray diffraction (XRD), scanning electron microscopy, absorption spectrum, photoluminescence (PL) and Raman spectroscopy. Size of the produced cubes could be controlled in the range 10 µm-50 nm by varying the solvent:co-solvent ratio. Micro-sized cubes could be grown in the presence of water as a solvent, while ethanol, which acts as a co-solvent, is found to be effective in reducing the size to the nanoscale. XRD results show complete crystalline structures in a griceite phase. The PL result of pure nanocubes exhibits a broad band in the range 370-550 nm, while that doped with Ag shows a prominent band at 420 nm. Raman spectra of the pure and Ag-doped LiF samples display several bands located in the range 80-236 cm -1 . These results show that pure nanocubes of LiF have active colour centres without irradiation, which could be enhanced/modified by Ag dopants. This implies that these nanocubes might be useful in the development of optical devices.

  16. Nonlinear effects in the propagation of shortwave transverse sound in pure superconductors

    International Nuclear Information System (INIS)

    Gal'perin, Y.

    1982-01-01

    Various mechanisms are analyzed which lead to nonlinear phenomena (e.g., the dependence of the absorption coefficient and of the velocity of sound on its intensity) in the propagation of transverse shortwave sound in pure superconductors (the wavelength of the sound being much less than the mean free path of the quasiparticles). It is shown that the basic mechanism, over a wide range of superconductor parameters and of the sound intensity, is the so-called momentum nonlinearity. The latter is due to the distortion (induced by the sound wave) of the quasimomentum distribution of resonant electrons interacting with the wave. The dependences of the absorption coefficient and of the sound velocity on its intensity and on the temperature are analyzed in the vicinity of the superconducting transition point. The feasibility of an experimental study of nonlinear acoustic phenomena in the case of transverse sound is considered

  17. Metal release behavior of surface oxidized stainless steels into flowing high temperature pure water

    International Nuclear Information System (INIS)

    Fujiwara, Kazuo; Tomari, Haruo; Nakayama, Takenori; Shimogori, Kazutoshi; Ishigure, Kenkichi; Matsuura, Chihiro; Fujita, Norihiko; Ono, Shoichi.

    1987-01-01

    In order to clarify the effect of oxidation treatment of Type 304 SS on the inhibition of metal release into high temperature pure water, metal release rate of individual alloying element into flowing deionized water containing 50 ppb dissolved oxygen was measured as the function of exposure time on representative specimens oxidized in air and steam. The behavior of metal release was also discussed in relation to the structure of surface films. Among the alloying elements the amount of Fe ion, Cr ion and Fe crud in high temperature pure water tended to saturate with the exposure time and that of Ni ion and Co ion tended to increase monotonously with the exposure time for all specimens tested. And the treatment of steam-oxidation was the most effective to decrease the metal release of alloying elements and the treatment by air-oxidation also decreased the metal release. These tendencies were confirmed to correlate well with the structure of the surface films as it was in the results in the static autoclave test. (author)

  18. Bayero Journal of Pure and Applied Sciences: Submissions

    African Journals Online (AJOL)

    Bayero Journal of Pure and Applied Sciences (BAJOPAS) is an international journal that publishes original research and critical reviews in broad areas of ... Technology, Mathematical Sciences, Microbiology, Physics and Medical Sciences.

  19. Effects of hydrostatic pressure on the excitation-emission matrix (EEM) of a series of pure PAHs

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Zhi-juan [Ocean College, Zhejiang University of Technology, Hangzhou 310014 (China); Wang, Jie [College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014 (China); Ye, Shu-ming [College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027 (China); Jiang, Chun-yue, E-mail: zjjcy@zjut.edu.cn [College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014 (China); Chen, Hang [College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027 (China)

    2017-06-15

    The effects of hydrostatic pressure on the EEM of a series of pure PAHs (naphthalene, fluorene, phenanthrene, acenaphthene, fluoranthene, and anthracene) with three different concentrations (10{sup -6} mol L{sup -1}, 10{sup -5} mol L{sup -1}, and 10{sup -4} mol L{sup -1}) were investigated in a pressure range from 0.1 MPa to 60 MPa at room temperature. According to the EEM, 2 (naphthalene) to 12 (anthracene) fluorescence peaks were observed and the variation of EEM under high pressure were revealed by analyzing the fluorescence peaks positions and intensities with the increased hydrostatic pressure. It is found that fluorescence peak shifts were not detected in the compression, however, both the enhancement of intensity (e.g. naphthalene, 10{sup -6} mol L{sup -1}, peak of 225/330 nm, relative fluorescence intensity increased by 0.594) and reduction of intensity (e.g. fluorene, 10{sup -6} mol L{sup -1}, peak of 275/309 nm, relative fluorescence intensity decreased by 0.0966) were observed. Otherwise, the pressure effects were magnified when the concentration was increased (e.g. the relative fluorescence intensity of anthracene (peak of 380/425 nm) increased by 0.0165 (10{sup -6} mol L{sup -1}) and decreased by 0.479 (10{sup -6} mol L{sup -1}) when the pressure was elevated from 0.1 MPa to 60 MPa).

  20. pupyMPI - MPI implemented in pure Python

    DEFF Research Database (Denmark)

    Bromer, Rune; Hantho, Frederik; Vinter, Brian

    2011-01-01

    As distributed memory systems have become common, the de facto standard for communication is still the Message Passing Interface (MPI). pupyMPI is a pure Python implementation of a broad subset of the MPI 1.3 specifications that allows Python programmers to utilize multiple CPUs with datatypes...

  1. Axisymmetric Eigenmodes of Spheroidal Pure Electron Plasmas

    Science.gov (United States)

    Kawai, Yosuke; Saitoh, Haruhiko; Yoshida, Zensho; Kiwamoto, Yasuhito

    2010-11-01

    The axisymmetric electrostatic eigenmodes of spheroidal pure electron plasmas have been studied experimentally. It is confirmed that the observed spheroidal plasma attains a theoretically expected equilibrium density distribution, with the exception of a low-density halo distribution surrounding the plasma. When the eigenmode frequency observed for the plasma is compared with the frequency predicted by the dispersion relation derived under ideal conditions wherein the temperature is zero and the boundary is located at an infinite distance from the plasma, it is observed that the absolute value of the observed frequency is systematically higher than the theoretical prediction. Experimental examinations and numerical calculations indicate that the upward shift of the eigenmode frequency cannot be accounted for solely by the finite temperature effect, but is significantly affected by image charges induced on the conducting boundary and the resulting distortion of the density profile from the theoretical expectation.

  2. [Effect of sintering gold paste coating on the bonding strength of pure titanium and three low-fusing porcelains].

    Science.gov (United States)

    Zhang, Ya-li; Luo, Xiao-ping; Zhou, Li

    2012-05-01

    To study the effect of sintering gold paste coating of pure titanium on the adhesion of three porcelains following the protocol ISO 9693, and to investigate the titanium-porcelains interfaces. Sixty machined pure titanium samples were prepared in a rectangular shape according to ISO 9693 and divided equally into six groups. Half of the strips were coated with gold paste (Deckgold) and sintered. Three ultra-low-fusing dental porcelains (I: Initial Ti, S: Super porcelain Ti-22, T: TitanKeramik) were fused onto the titanium surfaces. A thin layer of bonding agent was only applied on the surfaces of uncoated gold specimens. The interface of the porcelain and titanium was observed with a field emission scanning electron microscope (FE-SEM) after metallographic preparation and sputtered with a very thin carbon layer of the embedded titanium-porcelain interface. After three-point bending test was performed, optical stereomicroscope was used to characterize the titanium-porcelains adhesion and determine the mode of failure. FE-SEM illustrated intermetallic compounds of Au-Ti formed with some visible microcracks in the gold layer and the interface of gold layer and ceramic. All the uncoated gold titanium-porcelain system showed predominately adhesive fracture at the titanium oxidation, whereas the failure modes in all gold coated systems were cohesive and adhesive, mainly cohesive. The three-point-bending test showed that the bonding strength of GS and GI groups [(37.08 ± 4.32) and (36.20 ± 2.40) MPa] were higher than those in uncoated groups [(31.56 ± 3.74) and (30.88 ± 2.60) MPa, P 0.05). The gold paste intermediate coatings can improve bond strengths of Super porcelain Ti-22 system and Initial Ti system, which have potential applications in clinical fields.

  3. Revival of pure titanium for dynamically loaded porous implants using additive manufacturing.

    Science.gov (United States)

    Wauthle, Ruben; Ahmadi, Seyed Mohammad; Amin Yavari, Saber; Mulier, Michiel; Zadpoor, Amir Abbas; Weinans, Harrie; Van Humbeeck, Jan; Kruth, Jean-Pierre; Schrooten, Jan

    2015-09-01

    Additive manufacturing techniques are getting more and more established as reliable methods for producing porous metal implants thanks to the almost full geometrical and mechanical control of the designed porous biomaterial. Today, Ti6Al4V ELI is still the most widely used material for porous implants, and none or little interest goes to pure titanium for use in orthopedic or load-bearing implants. Given the special mechanical behavior of cellular structures and the material properties inherent to the additive manufacturing of metals, the aim of this study is to investigate the properties of selective laser melted pure unalloyed titanium porous structures. Therefore, the static and dynamic compressive properties of pure titanium structures are determined and compared to previously reported results for identical structures made from Ti6Al4V ELI and tantalum. The results show that porous Ti6Al4V ELI still remains the strongest material for statically loaded applications, whereas pure titanium has a mechanical behavior similar to tantalum and is the material of choice for cyclically loaded porous implants. These findings are considered to be important for future implant developments since it announces a potential revival of the use of pure titanium for additively manufactured porous implants. Copyright © 2015 Elsevier B.V. All rights reserved.

  4. Optical characterization of pure vegetable oils and their biodiesels using Raman spectroscopy

    International Nuclear Information System (INIS)

    Firdous, S; Anwar, S; Waheed, A; Maraj, M

    2016-01-01

    Great concern regarding energy resources and environmental polution has increased interest in the study of alternative sources of energy. Biodiesels as an alternative fuel provide a suitable diesel oil substitute for internal combustion engines. The Raman spectra of pure biodiesels of soybean oil, olive oil, coconut oil, animal fats, and petroleum diesel are optically characterized for quality and biofuel as an alternative fuel. The most significant spectral differences are observed in the frequency range around 1457 cm −1 for pure petroleum diesel, 1427 for fats biodiesel, 1670 cm −1 for pure soybean oil, 1461 cm −1 for soybean oil based biodiesel, 1670 cm −1 for pure olive oil, 1666 cm −1 for olive oil based biodiesel, 1461 cm −1 for pure coconut oil, and 1460 cm −1 for coconut oil based biodiesel, which is used for the analysis of the phase composition of oils. A diode pump solid-state laser with a 532 nm wavelength is used as an illuminating light. It is demonstrated that the peak positions and relative intensities of the vibrations of the oils can be used to identify the biodiesel quality for being used as biofuel. (paper)

  5. The influence of non polar and polar molecules in mouse motile cells membranes and pure lipid bilayers.

    Directory of Open Access Journals (Sweden)

    Francisco J Sierra-Valdez

    Full Text Available We report an experimental study of mouse sperm motility that shows chief aspects characteristic of neurons: the anesthetic (produced by tetracaine and excitatory (produced by either caffeine or calcium effects and their antagonic action. While tetracaine inhibits sperm motility and caffeine has an excitatory action, the combination of these two substances balance the effects, producing a motility quite similar to that of control cells. We also study the effects of these agents (anesthetic and excitatory on the melting points of pure lipid liposomes constituted by 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC and dipalmitoyl phosphatidic acid (DPPA. Tetracaine induces a large fluidization of the membrane, shifting the liposomes melting transition temperature to much lower values. The effect of caffeine is null, but its addition to tetracaine-doped liposomes greatly screen the fluidization effect. A high calcium concentration stiffens pure lipid membranes and strongly reduces the effect of tetracaine. Molecular Dynamics Simulations are performed to further understand our experimental findings at the molecular level. We find a strong correlation between the effect of antagonic molecules that could explain how the mechanical properties suitable for normal cell functioning are affected and recovered.

  6. General quantitative analysis of stress partitioning and boundary conditions in undrained biphasic porous media via a purely macroscopic and purely variational approach

    Science.gov (United States)

    Serpieri, Roberto; Travascio, Francesco

    2016-03-01

    In poroelasticity, the effective stress law relates the external stress applied to the medium to the macroscopic strain of the solid phase and the interstitial pressure of the fluid saturating the mixture. Such relationship has been formerly introduced by Terzaghi in form of a principle. To date, no poroelastic theory is capable of recovering a stress partitioning law in agreement with Terzaghi's postulated one in the absence of ad hoc constitutive assumptions on the medium. We recently proposed a variational macroscopic continuum description of two-phase poroelasticity to derive a general biphasic formulation at finite deformations, termed variational macroscopic theory of porous media (VMTPM). Such approach proceeds from the inclusion of the intrinsic volumetric strain among the kinematic descriptors aside to macroscopic displacements, and as a variational theory, uses the Hamilton least-action principle as the unique primitive concept of mechanics invoked to derive momentum balance equations. In a previous related work it was shown that, for the subclass of undrained problems, VMTPM predicts that stress is partitioned in the two phases in strict compliance with Terzaghi's law, irrespective of the microstructural and constitutive features of a given medium. In the present contribution, we further develop the linearized framework of VMTPM to arrive at a general operative formula that allows the quantitative determination of stress partitioning in a jacketed test over a generic isotropic biphasic specimen. This formula is quantitative and general, in that it relates the partial phase stresses to the externally applied stress as function of partitioning coefficients that are all derived by strictly following a purely variational and purely macroscopic approach, and in the absence of any specific hypothesis on the microstructural or constitutive features of a given medium. To achieve this result, the stiffness coefficients of the theory are derived by using

  7. Comprehensive metabolomics to evaluate the impact of industrial processing on the phytochemical composition of vegetable purees

    NARCIS (Netherlands)

    Lopez-Sanchez, P.; Vos, de R.C.H.; Jonker, H.H.; Mumm, R.; Hall, R.D.; Bialek, L.; Leenman, R.; Strassburg, K.; Vreeken, R.; Hankemeier, T.; Schumm, S.; Duynhoven, van J.P.M.

    2015-01-01

    The effects of conventional industrial processing steps on global phytochemical composition of broccoli, tomato and carrot purees were investigated by using a range of complementary targeted and untargeted metabolomics approaches including LC–PDA for vitamins, 1H NMR for polar metabolites, accurate

  8. Microbial and Sensory Effects of Combined High Hydrostatic Pressure and Dense Phase Carbon Dioxide Process on Feijoa Puree.

    Science.gov (United States)

    Duong, Trang; Balaban, Murat; Perera, Conrad; Bi, Xiufang

    2015-11-01

    High hydrostatic pressure (HHP) is used for microbial inactivation in foods. Addition of carbon dioxide (CO2) to HHP can improve microbial and enzyme inactivation. This study investigated microbial effects of combined HHP and CO2 on Escherichia coli, Bacillus subtilis, and Saccharomyces cerevisiae, and evaluated sensory attributes of treated feijoa fruit puree (pH 3.2). Microorganisms in their growth media and feijoa puree were treated with HHP alone (HHP), or saturated with CO2 at 1 atm (HHPcarb), or 0.4%w/w of CO2 was injected into the package (HHPcarb+CO2). Microbial samples were processed at 200 to 400 MPa, 25 °C, 2 to 6 min. Feijoa samples were processed at 600 MPa, 20 °C, 5 min, then served with and without added sucrose (10%w/w). Treated samples were analyzed for microbial viability and sensory evaluation. Addition of CO2 enhanced microbial inactivation of HHP from 1.7-log to 4.3-log reduction in E. coli at 400 MPa, 4 min, and reduction of >6.5 logs in B. subtilis (vegetative cells) starting at 200 MPa, 2 min. For yeast, HHPcarb+CO2 increased the inactivation of HHP from 4.7-log to 6.2-log reduction at 250 MPa, 4 min. The synergistic effect of CO2 with HHP increased with increasing time and pressure. HHPcarb+CO2 treatment did not alter the appearance and color, while affecting the texture and flavor of unsweetened feijoa samples. There were no differences in sensory attributes and preferences between HHPcarb+CO2 and fresh sweetened products. Addition of CO2 in HHP treatment can reduce process pressure and time, and better preserve product quality. A higher microbial inactivation of Escherichia coli, Bacillus subtilis and Saccharomyces cerevisiae by combining dense phase carbon dioxide and high hydrostatic pressure was observed. For sweetened products there were no significant differences in sensory attributes and preferences between samples treated by the combined method and the fresh samples. In conclusion, addition of CO2 in HHP treatment of juices could

  9. Modeling the adsorption of mixed gases based on pure gas adsorption properties

    NARCIS (Netherlands)

    Tzabar, N.; Holland, H. J.; Vermeer, C. H.; Ter Brake, H. J.M.

    2015-01-01

    Sorption-based Joule-Thomson (JT) cryocoolers usually operate with pure gases. A sorption-based compressor has many benefits; however, it is limited by the pressure ratios it can provide. Using a mixed-refrigerant (MR) instead of a pure refrigerant in JT cryocoolers allows working at much lower

  10. About possibility of creation of ecologically pure, safe nuclear power plants on the basis of high-effective resonant neutron interaction with splitting substances

    International Nuclear Information System (INIS)

    Irdyncheyev, L.A.; Malofeyev, A.M.; Frid, E.S.; Abramov, E.P.

    1993-01-01

    Currently the most important problem in nuclear engineering is creation of ecologically pure, safe nuclear power plants in the context of real danger of global ecological pollution of the environment with long-lived fission products and the resultant transuranium nuclides. The problem can be solved by creating nuclear power plants on the basis of high-effective resonant interaction (HERI). Such power plants would provide the total cycle, including nuclear fuel production (Plutonium-239 from Uranium-238), combustion and waste products salvaging by way of transformation of radioactive nuclides into stable isotopes

  11. Canonical form of three-fermion pure-states with six single particle states

    International Nuclear Information System (INIS)

    Chen, Lin; Ž Ðoković, Dragomir; Grassl, Markus; Zeng, Bei

    2014-01-01

    We construct a canonical form for pure states in ∧ 3 (C 6 ), the three-fermion system with six single particle states, under local unitary (LU) transformations, i.e., the unitary group U(6). We also construct a minimal set of generators of the algebra of polynomial U(6)-invariants on ∧ 3 (C 6 ). It turns out that this algebra is isomorphic to the algebra of polynomial LU-invariants of three-qubits which are additionally invariant under qubit permutations. As a consequence of this surprising fact, we deduce that there is a one-to-one correspondence between the U(6)-orbits of pure three-fermion states in ∧ 3 (C 6 ) and the LU orbits of pure three-qubit states when qubit permutations are allowed. As an important byproduct, we obtain a new canonical form for pure three-qubit states under LU transformations U(2) × U(2) × U(2) (no qubit permutations allowed)

  12. Proton irradiation studies on pure Ti and Ti-6Al-4V

    Energy Technology Data Exchange (ETDEWEB)

    Dutta Gupta, A. [Variable Energy Cyclotron Centre, HBNI, 1/AF Bidhannagar, Kolkata (India); Mukherjee, P., E-mail: paramita@vecc.gov.in [Variable Energy Cyclotron Centre, HBNI, 1/AF Bidhannagar, Kolkata (India); Gayathri, N.; Bhattacharyya, P.; Bhattacharya, M. [Variable Energy Cyclotron Centre, HBNI, 1/AF Bidhannagar, Kolkata (India); Sarkar, Apu [Materials Group, Bhabha Atomic Research Centre, Mumbai (India); Sen, S. [Mechanical Engineering, Jadavpur University, Kolkata (India); Mitra, M.K. [Metallurgical and Materials Engineering, Jadavpur University, Kolkata (India)

    2016-11-15

    Post irradiated microstructural characterisation of pure Ti and Ti-6Al-4V has been done as a function of dose using different model based techniques of X-ray diffraction line profile analysis. There is a systematic change of domain size for both the materials with dose but the microstrain within the domain remains almost unaltered. The domain size appears to be lower for pure Ti at all doses as compared to Ti-6Al-4V alloy. XRD peaks became highly asymmetric particularly at a dose of 5 × 10{sup 21} p/m{sup 2} for Ti-6Al-4V samples which is not observed for pure Ti at the same dose. This may be attributed to the segregation of alloying elements as a result of irradiation. Microhardness values increases with dose for pure Ti and then saturates at higher doses whereas microhardness values are found to decrease at higher doses for Ti-6Al-4V.

  13. Investigations in Pure Mathematics: A Constructivist Perspective.

    Science.gov (United States)

    Hirst, Keith; Shiu, Christine

    1995-01-01

    Discusses an investigative, constructivist approach in the context of undergraduate mathematics, with particular reference to pure mathematics, general aims and objectives, assessment strategies, and problems of supervision that affect tutors and lecturers using this approach. Gives students' views on their experiences in this mode of working. (19…

  14. Word frequency effects in immediate serial recall of pure and mixed lists: tests of the associative link hypothesis.

    Science.gov (United States)

    Saint-Aubin, Jean; LeBlanc, Jacinthe

    2005-12-01

    In immediate serial recall, high-frequency words are better recalled than low-frequency words. Recently, it has been suggested that high-frequency words are better recalled because of their better long-term associative links, and not because of the intrinsic properties of their long-term representations. In the experiment reported here, recall performance was compared for pure lists of high- and low-frequency words, and for mixed lists composed of either one low- and five high-frequency words or the reverse. The usual advantage of high-frequency words was found with pure lists and this advantage was reduced, but still significant with mixed lists composed of five low-frequency words. However, the low-frequency word included in a high-frequency list was recalled just as well as high-frequency words. Results are challenging for the associative link hypothesis and are best interpreted within an item-based reconstruction hypothesis, along with a distinctiveness account.

  15. Pure Neutron Matter Constraints and Nuclear Symmetry Energy

    International Nuclear Information System (INIS)

    Fattoyev, F J; Newton, W G; Xu, Jun; Li, Bao-An

    2013-01-01

    In this review, we will discuss the results of our recent work [1] to study the general optimization of the pure isovector parameters of the popular relativistic mean-field (RMF) and Skyrme-Hartree-Fock (SHF) nuclear energy-density functionals (EDFs), using constraints on the pure neutron matter (PNM) equation of state (EoS) from recent ab initio calculations. By using RMF and SHF parameterizations that give equivalent predictions for ground-state properties of doubly magic nuclei and properties of symmetric nuclear matter (SNM) and PNM, we found that such optimization leads to broadly consistent symmetry energy J and its slope parameter L at saturation density within a tight range of α(J) sym , (b) the symmetry energy at supra-saturation densities, and (c) the radius of neutron stars.

  16. Analysis of pure and malachite green doped polysulfone sample using FT-IR technique

    Science.gov (United States)

    Nayak, Rashmi J.; Khare, P. K.; Nayak, J. G.

    2018-05-01

    The sample of pure and malachite green doped Polysulfone in the form of foil was prepared by isothermal immersion technique. For the preparation of pure sample 4 gm of Polysulfone was dissolved in 50 ml of Dimethyl farmamide (DMF) solvent, while for the preparation of doped sample 10 mg, 50 mg and 100 mg Malachite Green was mixed with 4 gm of Polysulfone respectively. For the study of structural characterization of these pure and doped sample, Fourier Transform Infra-Red Spectroscopy (FT-IR) technique was used. This study shows that the intensity of transmittance decreases as the ratio of doping increases in pure polysulfone. The reduction in intensity of transmittance is clearly apparent in the present case more over the bands were broader which indicates towards charge transfer interaction between the donar and acceptor molecule.

  17. Relation between catalyst-assisted transformation and multiple-copy transformation for bipartite pure states

    International Nuclear Information System (INIS)

    Feng Yuan; Duan Runyao; Ying Mingsheng

    2006-01-01

    We show that in some cases, catalyst-assisted entanglement transformation cannot be implemented by multiple-copy transformation for pure states. This fact, together with the result we obtained in R. Y. Duan, Y. Feng, X. Li, and M. S. Ying, Phys. Rev. A 71, 042319 (2005), namely that the latter can be completely implemented by the former, indicates that catalyst-assisted transformation is strictly more powerful than multiple-copy transformation. For the purely probabilistic setting we find, however, these two kinds of transformations are geometrically equivalent in the sense that the sets of pure states that can be converted into a given pure state with maximal probabilities not less than a given value have the same closure, regardless of whether catalyst-assisted transformation or multiple-copy transformation is used

  18. Can Kinesiological Activities Change "Pure" Motor Development in Preschool Children during One School Year?

    Science.gov (United States)

    Krneta, Željko; Casals, Cristina; Bala, Gustav; Madić, Dejan; Pavlović, Slobodan; Drid, Patrik

    2015-07-01

    The purpose of this study was to evaluate the effects of an additional, organized, and more intensive kinesiological treatment on "pure" motor abilities in preschool children. In the present study an experimental treatment was carried out on a sample of 37 preschool boys by applying kinesiological activities. The 60 minute treatment was applied over a period of one school year (9 months), twice a week. A control group of 31 boys were trained according to the regular program for preschool institutions. Treatment effects were assessed by 8 motor ability tests and 5 anthropometric measures. The significant differences between the groups, which were observed after the final measurement and compared to the initial one, proved that the kinesiological treatment had a positive impact on the general development of "pure" motor abilities. The most significant effect of experimental kinesiological treatment was the improvement in whole body force, flexibility and coordination of preschool boys. These findings, obtained only in one school year, point to the importance of physical exercise and the application of additional kinesiological activities with various modalities, to improve motor development, even morphological growth and development in preschool children. The effects of the perennial application of kinesiological activities, under the supervision of kinesiological professionals, could be beneficial and could form the basis for a better biological and motor development in older age.

  19. Probabilistic teleportation of an arbitrary pure state of two atoms

    Institute of Scientific and Technical Information of China (English)

    Yang Zhen-Biao; Wu Huai-Zhi; Su Wan-Jun

    2007-01-01

    In the context of microwave cavity QED, this paper proposes a new scheme for teleportation of an arbitrary pure state of two atoms. The scheme is very different from the previous ones which achieve the integrated state measurement,it deals in a probabilistic but simplified way. In the scheme, no additional atoms are involved and thus only two atoms are required to be detected. The scheme can also be used for the teleportation of arbitrary pure states of many atoms or two-mode cavities.

  20. Generalized Gödel universes in higher dimensions and pure Lovelock gravity

    Science.gov (United States)

    Dadhich, Naresh; Molina, Alfred; Pons, Josep M.

    2017-10-01

    The Gödel universe is a homogeneous rotating dust with negative Λ which is a direct product of a three-dimensional pure rotation metric with a line. We would generalize it to higher dimensions for Einstein and pure Lovelock gravity with only one N th-order term. For higher-dimensional generalization, we have to include more rotations in the metric, and hence we shall begin with the corresponding pure rotation odd (d =2 n +1 )-dimensional metric involving n rotations, which eventually can be extended by a direct product with a line or a space of constant curvature for yielding a higher-dimensional Gödel universe. The considerations of n rotations and also of constant curvature spaces is a new line of generalization and is being considered for the first time.

  1. Effects of deep cryogenic treatment on the microstructure and mechanical properties of commercial pure zirconium

    Energy Technology Data Exchange (ETDEWEB)

    Yuan, Chao; Wang, Yunpeng; Sang, Deli; Li, Yijun; Jing, Lei; Fu, Ruidong, E-mail: rdfu@ysu.edu.cn; Zhang, Xiangyi

    2015-01-15

    Highlights: • The microstructure and mechanical properties of DCT-treated Zr were investigated. • DCT induced a change in grain orientation and improved internal stress. • Changes in grain orientation and internal stress increased dislocation density. • Hardness in basal planes was significantly larger than that in prism planes. • Strength levels were high and good ductility could still be achieved after DCT. - Abstract: The effects of deep cryogenic treatment (DCT) on the microstructure and mechanical properties of commercial pure zirconium were investigated. Experimental results indicated that DCT induced a change in grain orientation and improved internal stress, which in turn increased dislocation density that led to improved hardness. Hardness in basal planes was found to be significantly larger than that in prism planes. Moreover, strength was enhanced in DCT-treated zirconium and the ductility was comparable to that of as-annealed zirconium. This phenomenon was due to the increase in dislocation density and the good ductility resulting from the motion of pre-existing dislocations and specific dislocation configurations. DCT led to the transformation of tensile fracture mode from mixed-rupture characteristics of quasi-cleavage and dimples to quasi-cleavage, thereby increasing compatible deformation capabilities. The possible mechanisms underlying microstructural modification, tensile strength, and hardness improvement were discussed.

  2. Effects of deep cryogenic treatment on the microstructure and mechanical properties of commercial pure zirconium

    International Nuclear Information System (INIS)

    Yuan, Chao; Wang, Yunpeng; Sang, Deli; Li, Yijun; Jing, Lei; Fu, Ruidong; Zhang, Xiangyi

    2015-01-01

    Highlights: • The microstructure and mechanical properties of DCT-treated Zr were investigated. • DCT induced a change in grain orientation and improved internal stress. • Changes in grain orientation and internal stress increased dislocation density. • Hardness in basal planes was significantly larger than that in prism planes. • Strength levels were high and good ductility could still be achieved after DCT. - Abstract: The effects of deep cryogenic treatment (DCT) on the microstructure and mechanical properties of commercial pure zirconium were investigated. Experimental results indicated that DCT induced a change in grain orientation and improved internal stress, which in turn increased dislocation density that led to improved hardness. Hardness in basal planes was found to be significantly larger than that in prism planes. Moreover, strength was enhanced in DCT-treated zirconium and the ductility was comparable to that of as-annealed zirconium. This phenomenon was due to the increase in dislocation density and the good ductility resulting from the motion of pre-existing dislocations and specific dislocation configurations. DCT led to the transformation of tensile fracture mode from mixed-rupture characteristics of quasi-cleavage and dimples to quasi-cleavage, thereby increasing compatible deformation capabilities. The possible mechanisms underlying microstructural modification, tensile strength, and hardness improvement were discussed

  3. Genomewide mapping reveals a combination of different genetic ...

    Indian Academy of Sciences (India)

    could not investigate all kinds of genetic effects, especially epistatic effects, simultaneously on the whole genome. ... consistent with different loci affecting heterosis for different ...... Jones D. F. 1917 Dominance of linked factors as a means of.

  4. Computer Solution to the Game of Pure Strategy

    Directory of Open Access Journals (Sweden)

    Laurent Bartholdi

    2012-11-01

    Full Text Available We numerically solve the classical "Game of Pure Strategy" using linear programming. We notice an intricate even-odd behaviour in the results of our computations that seems to encourage odd or maximal bids.

  5. A randomised controlled trial of face to face versus pure online self-help cognitive behavioural treatment for perfectionism.

    Science.gov (United States)

    Egan, Sarah J; van Noort, Emily; Chee, Abby; Kane, Robert T; Hoiles, Kimberley J; Shafran, Roz; Wade, Tracey D

    2014-12-01

    Previous research has shown cognitive-behavioural treatment (CBT) to be effective in reducing perfectionism. The present study investigated the efficacy of two formats of CBT for perfectionism (CBT-P), face-to-face and pure online self-help, in reducing perfectionism and associated psychological symptoms. Participants were randomly allocated to face-to-face CBT-P (n = 18), pure online self-help CBT-P (n = 16), or a waitlist control period (n = 18). There was no significant change for the waitlist group on any of the outcome measures at the end of treatment. Both the face-to-face and pure online self-help groups reported significant reductions at the end of treatment for the perfectionism variables which were maintained at the 6-month follow-up. The face-to-face group also reported significant reductions over this time in depression, anxiety, and stress, and a significant pre-post increase in self-esteem, all of which were maintained at the 6-month follow-up. In contrast, the pure online self-help group showed no significant changes on these outcomes. The face-to-face group was statistically superior to the pure online self-help group at follow-up on the perfectionism measures, concern over mistakes and personal standards. The results show promising evidence for CBT for perfectionism, especially when offered face to face, where sustained benefit across a broad range of outcomes can be expected. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.

  6. Assessment of semen quality in pure and crossbred Jersey bulls

    Science.gov (United States)

    Kumar, Umesh; Gawande, Ajay P.; Sahatpure, Sunil K.; Patil, Manoj S.; Lakde, Chetan K.; Bonde, Sachin W.; Borkar, Pradnyankur L.; Poharkar, Ajay J.; Ramteke, Baldeo R.

    2015-01-01

    Aim: To compare the seminal attributes of neat, pre-freeze (at equilibration), and post-freeze (24 h after freezing) semen in pure and crossbred Jersey bulls. Materials and Methods: Total 36 ejaculates (3 ejaculates from each bull) were collected from 6 pure Jersey and 6 crossbred Jersey bulls and evaluated for various seminal attributes during neat, pre-freeze, and post-freeze semen. Results: The mean (±standard error [SE]) values of neat semen characteristics in pure and crossbred Jersey bulls were recorded such as volume (ml), color, consistency, mass activity (scale: 0-5), and sperm concentration (millions/ml). The extended semen was further investigated at pre-freeze and post-freeze stages and the mean (±SE) values recorded at neat, pre-freeze, and post-freeze semen were compared between pure and crossbred Jersey bulls; sperm motility (80.55±1.70%, 62.77±1.35%, 46.11±1.43% vs. 80.00±1.80%, 65.00±1.66%, 47.22±1.08%), live sperm count (83.63±1.08%, 71.72±1.09%, 58.67±1.02% vs. 80.00±1.08%, 67.91±1.20%, 51.63±0.97%), total abnormal sperm count (8.38±0.32%, 12.30±0.39%, 16.75±0.42% vs. 9.00±0.45%, 12.19±0.48%, 18.11±0.64%), hypo-osmotic swelling (HOS) reacted spermatozoa (71.88±0.77%, 62.05±0.80%, 47.27±1.05% vs. 72.77±1.02%, 62.11±0.89%, 45.94±1.33%), acrosome integrity (89.05±0.83%, 81.33±0.71%, 71.94±0.86% vs. 86.55±0.57%, 78.66±0.42%, 69.38±0.53%), and DNA integrity (99.88±0.07%, 100, 99.66±0.11% vs. 99.94±0.05%, 100, 99.44±0.18%,). The volume, color, consistency, sperm concentration, and initial motility in pure and crossbred Jersey bulls did not differ significantly (p>0.05). The mass activity was significantly (p0.05) was observed in abnormal sperm; HOS reacted spermatozoa and DNA integrity percentage among breeds. Conclusion: It may be concluded that the quality of pure Jersey bull semen was comparatively better than the crossbred Jersey bulls. PMID:27047028

  7. Acceptability of Musa Balbisiana (Saba Banana Puree in Two Treatments in Making Ice Cream

    Directory of Open Access Journals (Sweden)

    Mario A. De Castro Jr.

    2016-11-01

    Full Text Available Musa Balbisiana or Saba is a variety of banana fruit that is nutritious and readily available in the market the whole year round. This experimental study aimed to determine the acceptability of the ice cream made from Saba banana puree in two treatments (treatment 1- cooked puree and treatment 2- uncooked puree. Data gathered were described and analyzed using a special Analysis of Variance. The sensory characteristics of the ice cream in two treatments were compared with one another based on the 9-point hedonic scale utilized by trained panelist in the education sector in secondary, tertiary and graduate school level that specialized in food related discipline such as Food Technology, Food Service Management, Technology and Livelihood Education- Food Trades and Hotel and Restaurant Management. Results indicated that in treatment 1( cooked puree the taste and texture of the ice cream were liked extremely however its color was rated liked very much, while in treatment 2 (uncooked puree the texture and color were rated liked moderately while its taste was rated liked very much. A comparison of the sensory characteristics between the two treatments revealed that there is a significant difference in terms of taste, texture and color and overall acceptability of the Saba banana ice cream. It is then recommended that in preparing Saba banana puree using treatment 1 (cooking method, the fruit should be subjected in numerous sieving process using a fine mesh siever or sifter to produce good quality puree texture.

  8. Do all pure entangled states violate Bell's inequalities for correlation functions?

    Science.gov (United States)

    Zukowski, Marek; Brukner, Caslav; Laskowski, Wiesław; Wieśniak, Marcin

    2002-05-27

    Any pure entangled state of two particles violates a Bell inequality for two-particle correlation functions (Gisin's theorem). We show that there exist pure entangled N>2 qubit states that do not violate any Bell inequality for N particle correlation functions for experiments involving two dichotomic observables per local measuring station. We also find that Mermin-Ardehali-Belinskii-Klyshko inequalities may not always be optimal for refutation of local realistic description.

  9. Positive inotropic effects of RP 62719, a new pure class III antiarrhythmic agent, on guinea pig myocardium.

    Science.gov (United States)

    Beregi, J P; Escande, D; Coudray, N; Mery, P; Mestre, M; Chemla, D; Lecarpentier, Y

    1992-12-01

    The mechanical effects of RP 62719 [(-)1-[-2-(3,4-dihydro-2H-1- benzopyran-4-yl)ethyl]-4-(3,4-dimethoxyphenyl)-piperidine] were tested in vitro on guinea pig left ventricular papillary muscle. RP 62719 is a novel pure class III antiarrhythmic agent known to prolong the cardiac action potential duration by selectively blocking the inward rectifying K+ current. Mechanical parameters were determined from contraction and relaxation phases under isotonic and isometric conditions. At a concentration of 0.02 microM, RP 62719 did not produce significant effects on inotropy or lusitropy. At 0.2 and 2 microM, the drug improved contraction under both heavy and low loading conditions, as evidenced by a 30% increase in maximum unloaded shortening velocity (Vmax, P delta L, P force normalized per cross-sectional area (AF/s, P force derivative per mm2 (+dF/s, P force derivative per mm2 (-dF/s, P < .001). At a higher concentration (20 microM), effects of RP 62719 on inotropy and lusitropy were less marked, thus accounting for the bell-shaped form of the dose-response curve. An increase in the extracellular Ca++ concentration from 2.5 to 3.75 mM improved inotropy to a similar extent (+30-50%) as did 2 microM RP 62719. However, lusitropy and mechanical coupling between contraction and relaxation were not modified in the same proportion under RP 62719 and under 3.75 mM Ca++.(ABSTRACT TRUNCATED AT 250 WORDS)

  10. 76 FR 69284 - Pure Magnesium From China

    Science.gov (United States)

    2011-11-08

    ... China Determination On the basis of the record \\1\\ developed in the subject five-year review, the United... China would be likely to lead to continuation or recurrence of material injury to an industry in the...), entitled Pure Magnesium from China: Investigation No. 731-TA-696 (Third Review). Issued: November 2, 2011...

  11. High temperature internal friction in pure aluminium

    International Nuclear Information System (INIS)

    Aboagye, J.K.; Payida, D.S.

    1982-05-01

    The temperature dependence of internal friction of nearly pure aluminium (99.99% aluminium) has been carefully measured as a function of annealing temperature and hence grain size. The results indicate that, provided the frequency and annealing temperature are held constant, the internal friction increases with temperature until some maximum value is attained and then begins to go down as the temperature is further increased. It is also noted that the internal friction decreases with annealing temperature and that annealing time has the same effect as annealing temperature. It is also noted that the internal friction peak is shifted towards higher temperatures as annealing temperature is increased. It is surmised that the grain size or the total grain boundary volume determines the height of the internal friction curve and that the order-disorder transitions at the grain boundaries induced by both entropy and energy gradients give rise to internal friction peaks in polycrystals. (author)

  12. Corrosion Prevention of Steel Reinforcement in 7.5% NaCl Solution using Pure Magnesium Anode

    Science.gov (United States)

    Iyer Murthy, Yogesh; Gandhi, Sumit; Kumar, Abhishek

    2018-03-01

    The current work investigates the performance of pure Magnesium on corrosion prevention of steel reinforcements by way of sacrificial anoding. Two set of six steel reinforcements were tested for half-cell potential, weight loss, anode efficiency and tensile strength for each of the sacrificial anodes in a high chloride atmosphere of 7.5% NaCl in tap water. Significant reduction in weight of anode was observed during the initial 12 days. The reduction in weight of steel reinforcements tied with anodes was found to be negligible, while that of reinforcements without anodes was significantly higher. Five distinct zones of corrosion were observed during the test. The tensile strength of steel cathodically protected by Mg alloy anodes was found less affected. It could be concluded that pure Mg anode provides an effective way of corrosion mitigation.

  13. Controlled Remote State Preparation via General Pure Three-Qubit State

    Directory of Open Access Journals (Sweden)

    Yuebo Zha

    2015-07-01

    Full Text Available The protocols for controlled remote state preparation of a single qubit and a general two-qubit state are presented in this paper. The general pure three-qubit states are chosen as shared quantum channel, which are not Local operations and classical communication (LOCC equivalent to the mostly used GHz state. This is the first time that general pure three-qubit states have been introduced to complete remote state preparation. The probability of successful preparation is presented. Moreover, in some special cases, the successful probability could reach a unit value.

  14. Caring for the carer: a systematic review of pure technology-based cognitive behavioral therapy (TB-CBT) interventions for dementia carers.

    Science.gov (United States)

    Scott, Jennifer L; Dawkins, Sarah; Quinn, Michael G; Sanderson, Kristy; Elliott, Kate-Ellen J; Stirling, Christine; Schüz, Ben; Robinson, Andrew

    2016-08-01

    Face-to-face delivery of CBT is not always optimal or practical for informal dementia carers (DCs). Technology-based formats of CBT delivery (TB-CBT) have been developed with the aim to improve client engagement and accessibility, and lower delivery costs, and offers potential benefits for DCs. However, research of TB-CBT for DCs has maintained heavy reliance on therapist involvement. The efficacy of pure TB-CBT interventions for DCs is not currently established Methods: A systematic review of trials of pure TB-CBT intervention for DCs from 1995 was conducted. PsycINFO, Cochrane Reviews, Scopus and MedLine databases were searched using key terms related to CBT, carers and dementia. Four hundred and forty two articles were identified, and inclusion/exclusion criteria were applied; studies were only retained if quantitative data was available, and there was no active therapist contact. Four articles were retained; two randomized and two waitlist control trials. Methodological and reporting quality was assessed. Meta-analyses were conducted for the outcome measures of caregiver depression. Meta-analysis revealed small significant post-intervention effects of pure TB-CBT interventions for depression; equivalent to face-to-face interventions. However, there is no evidence regarding long-term efficacy of pure TB-CBT for DCs. The systematic review further identified critical methodological and reporting shortcomings pertaining to these trials Conclusions: Pure TB-CBT interventions may offer a convenient, economical method for delivering psychological interventions to DCs. Future research needs to investigate their long-term efficacy, and consider potential moderating and mediating factors underpinning the mechanisms of effect of these programs. This will help to provide more targeted interventions to this underserviced population.

  15. Anodic polarization behavior of pure copper in carbonate solutions

    International Nuclear Information System (INIS)

    Kawasaki, Manabu; Taniguchi, Naoki; Naitou, Morimasa

    2008-03-01

    Copper is one of the candidate materials for overpacks. The redox condition at the early stage of the post closure will be oxidizing. In order to understand the influence of environmental factors on the corrosion behavior of copper in such oxidizing environment, anodic polarization tests were performed in carbonate aqueous solution with varying the concentration of representative chemical species in groundwater. As the results of potentiodynamic and potentiostatic tests, anodic polarization behavior of pure copper was summarized as follows; Carbonate ion and bicarbonate ion promoted the passivation of pure copper, and suppressed the initiation of film breakdown. Chloride ion promoted both the active dissolution and initiation of film breakdown of pure copper. The influence of sulfate ion and pH was small, but the action of sulfate ion to the pure copper was similar to that of chloride ion, and the increase of pH was likely to promote the passivation and suppress the initiation of film breakdown. The film breakdown potential, Eb, was represented as a function of the ratio of aggressive ion and inhibiting ion such as [Cl - ]/[HCO 3 - ], [SO 4 2- ]/[HCO 3 - ]. When the ratio exceeds a certain value, the anodic polarization curve becomes active dissolution type so that no macroscopic film breakdown can not be occurred. The lower limit of Eb in passive type region was estimated to be about -200 mV vs. SCE. As the results of potentio static tests, the corrosion form near the Eb was uniform dissolution over the surface, but pitting corrosion and non-uniform corrosion occurred according to the condition of the test solution. Neither pitting corrosion nor non-uniform corrosion occurred at the potential below Eb in every test cases. (author)

  16. Modeling pure culture heterotrophic production of polyhydroxybutyrate (PHB).

    Science.gov (United States)

    Mozumder, Md Salatul Islam; Goormachtigh, Laurens; Garcia-Gonzalez, Linsey; De Wever, Heleen; Volcke, Eveline I P

    2014-03-01

    In this contribution a mechanistic model describing the production of polyhydroxybutyrate (PHB) through pure-culture fermentation was developed, calibrated and validated for two different substrates, namely glucose and waste glycerol. In both cases, non-growth-associated PHB production was triggered by applying nitrogen limitation. The occurrence of some growth-associated PHB production besides non-growth-associated PHB production was demonstrated, although it is inhibited in the presence of nitrogen. Other phenomena observed experimentally and described by the model included biomass growth on PHB and non-linear product inhibition of PHB production. The accumulated impurities from the waste substrate negatively affected the obtained maximum PHB content. Overall, the developed mathematical model provided an accurate prediction of the dynamic behavior of heterotrophic biomass growth and PHB production in a two-phase pure culture system. Copyright © 2013 Elsevier Ltd. All rights reserved.

  17. Split-Hopkinson pressure bar tests on pure tantalum

    International Nuclear Information System (INIS)

    Dick, Richard D.; Armstrong, Ronald W.; Williams, John D.

    1998-01-01

    Pure tantalum (Ta) was loaded in compression by a split-Hopkinson pressure bar (SHPB) to strain rates from 450 to 6350 s -1 . The results are compared with SHPB data for commercial Ta and with predictions from the constitutive model for Ta developed by Zerilli and Armstrong (Z-A). The main conclusions are: (1) the flow stress versus log strain rate agree with the Z-A constitutive model and other reported data, (2) uniform strain exponents computed on a true stress-strain basis for pure Ta are somewhat greater than those determined from SHPB data for commercial Ta, and (3) in both cases the uniform strain exponents versus log strain rate are in good agreement with predictions from the Z-A constitutive model for strain rates above 1500 s -1 without a clear indication of dislocation generation

  18. Tuning the magnetic properties of pure hafnium by high pressure torsion

    International Nuclear Information System (INIS)

    Cepeda-Jiménez, C.M.; Beltrán, J.I.; Hernando, A.; García, M.A.; Ynduráin, F.; Zhilyaev, A.; Pérez-Prado, M.T.

    2017-01-01

    This work demonstrates that room temperature (RT) ferromagnetism might be triggered in pure hafnium (Hf), a classic paramagnet, by severe plastic deformation (SPD) via high pressure torsion (HPT). The origin of this phenomenon is elucidated by a combined approach including density functional theory (DFT) calculations and transmission electron microscopy (TEM). In particular, it is shown that the elastic lattice distorsions induced in pure Hf as a consequence of grain refinement down to the nanocrystalline regime by HPT lead to the development of a new monoclinic crystalline structure that exhibits a spontaneous magnetization at RT. DFT calculations are utilized to prove that local stretching of the original pure Hf hexagonal close packed (hcp) lattice along specific pyramidal directions, due to the presence of internal stresses in the deformed nanostructure, may give rise to the emergence of the monoclinic phase, which is endowed with a net magnetic moment. An excellent agreement is found between DFT calculations and experimental TEM observations, which provide a first evidence of the presence of the pure Hf monoclinic crystal lattice. This work shows that SPD may constitute a viable, yet widely unexplored, strategy to tune the magnetic properties and, in particular, to induce RT ferromagnetism in bulk non-magnetic metals.

  19. Analysis of corneal topography in patients with pure microphthalmia in Eastern China.

    Science.gov (United States)

    Hu, Pei-Hong; Gao, Gui-Ping; Yu, Yao; Pei, Chong-Gang; Zhou, Qiong; Huang, Xin; Zhang, Ying; Shao, Yi

    2015-12-01

    To determine the typical corneal changes in pure microphthalmia using a corneal topography system and identify characteristics that may assist in early diagnosis. Patients with pure microphthalmia and healthy control subjects underwent corneal topography analysis (Orbscan IIZ® Corneal Topography System; Bausch and Lomb, Bridgewater, NJ, USA) to determine degree of corneal astigmatism (mean A), simulation of corneal astigmatism (sim A), mean keratometry (mean K), simulated keratometry (sim K), irregularities in the 3 - and 5-mm zone, and mean thickness of nine distinct corneal regions. Patients with pure microphthalmia (n = 12) had significantly higher mean K, sim K, mean A, sim A, 3.0 mm irregularity and 5.0 mm irregularity, and exhibited significantly more false keratoconus than controls (n = 12). There was a significant between-group difference in the morphology of the anterior corneal surface and the central curvature of the cornea. Changes in corneal morphology observed in this study could be useful in borderline situations to confirm the diagnosis of pure microphthalmia. © The Author(s) 2015.

  20. The study of behavior titanium pure commercially coated with hydroxyapatite and zirconia

    Science.gov (United States)

    Aneed, Shaymaa Hashim; Salih, Ayad Ahmed; Khazaal, Ahlam Rashid; Hasan, Aqeel F.; Hamodi, Jamal Fadhil; Jasim, Kareem Ali; Mahdi, Shatha H.; AL-Maiyaly, Bushra K. H.; Hassun, Hanan K.

    2018-05-01

    In this research was studied the effect of adding zirconia to hydroxyapatite in the coting of commercially pure titanium (cpTi), by using electrophoretic deposition (EPD) when using micron particle (waves) size limit (0.25-0.5) micron, and deposition was effected with different coating periods(2,4,6) mints, and annealing at 500 °C, it founded there was an improvement in the corrosion properties, as the value of the open circuit potential (OCP) for coated titanium was reach to (-0.262) volt compared with to uncoated titanium was reach to (-0.528)volt. Note that the coating process is perfectly homogeneous to the entire area of the metal used.

  1. Preparing Pseudo-Pure States in a Quadrupolar Spin System Using Optimal Control

    International Nuclear Information System (INIS)

    Tan Yi-Peng; Li Jun; Zhou Xian-Yi; Peng Xin-Hua; Du Jiang-Feng; Nie Xin-Fang; Chen Hong-Wei

    2012-01-01

    Pseudo-pure state (PPS) preparation is crucial in nuclear magnetic resonance quantum computation. There have been some methods in spin-1/2 systems and a few attempts in quadrupolar spin systems. As optimal control via gradient ascent pulses engineering (GRAPE) has been widely used in quantum information science, we apply this technique to PPS preparation in quadrupolar spin systems. This approach shows an effective and fast quantum control method for both the state preparation and the realization of quantum gates in quadrupolar systems

  2. Purely geometric path integral for spin-foams

    International Nuclear Information System (INIS)

    Shirazi, Atousa Chaharsough; Engle, Jonathan

    2014-01-01

    Spin-foams are a proposal for defining the dynamics of loop quantum gravity via path integral. In order for a path integral to be at least formally equivalent to the corresponding canonical quantization, at each point in the space of histories it is important that the integrand have not only the correct phase—a topic of recent focus in spin-foams—but also the correct modulus, usually referred to as the measure factor. The correct measure factor descends from the Liouville measure on the reduced phase space, and its calculation is a task of canonical analysis. The covariant formulation of gravity from which spin-foams are derived is the Plebanski–Holst formulation, in which the basic variables are a Lorentz connection and a Lorentz-algebra valued 2-form, called the Plebanski 2-form. However, in the final spin-foam sum, one usually sums over only spins and intertwiners, which label eigenstates of the Plebanski 2-form alone. The spin-foam sum is therefore a discretized version of a Plebanski–Holst path integral in which only the Plebanski 2-form appears, and in which the connection degrees of freedom have been integrated out. We call this a purely geometric Plebanski–Holst path integral. In prior work in which one of the authors was involved, the measure factor for the Plebanski–Holst path integral with both connection and 2-form variables was calculated. Before one discretizes this measure and incorporates it into a spin-foam sum, however, one must integrate out the connection in order to obtain the purely geometric version of the path integral. To calculate this purely geometric path integral is the principal task of the present paper, and it is done in two independent ways. Background independence of the resulting path integral is discussed in the final section, and gauge-fixing is discussed in appendix B. (paper)

  3. Quantum entanglement as an aspect of pure spinor geometry

    International Nuclear Information System (INIS)

    Kiosses, V

    2014-01-01

    Relying on the mathematical analogy of the pure states of a two-qubit system with four-component Dirac spinors, we provide an alternative consideration of quantum entanglement using the mathematical formulation of Cartan's pure spinors. A result of our analysis is that the Cartan equation of a two-qubit state is entanglement sensitive in the same way that the Dirac equation for fermions is mass sensitive. The Cartan equation for unentangled qubits is reduced to a pair of Cartan equations for single qubits as the Dirac equation for massless fermions separates into two Weyl equations. Finally, we establish a correspondence between the separability condition in qubit geometry and the separability condition in spinor geometry. (paper)

  4. Pure subrings of the rings Zχ

    International Nuclear Information System (INIS)

    Tsarev, Andrei V

    2009-01-01

    Pure subrings of finite rank in the Z-adic completion of the ring of integers and in its homomorphic images are considered. Certain properties of these rings are studied (existence of an identity element, decomposability into a direct sum of essentially indecomposable ideals, condition for embeddability into a csp-ring, etc.). Additive groups of these rings and conditions under which these rings are subrings of algebraic number fields are described. Bibliography: 12 titles.

  5. Pure water syndrome: Bacteriological quality of Sachet- packed ...

    African Journals Online (AJOL)

    Pure water syndrome: Bacteriological quality of Sachet- packed drinking water ... of fecal contamination and inadequate water treatment or no treatment at all. ... of hygiene criteria were present in the range of 98 and 106 cfu/100ml of water ...

  6. Effect of sonochemical synthesized TiO2 nanoparticles and coagulation bath temperature on morphology, thermal stability and pure water flux of asymmetric cellulose acetate membranes prepared via phase inversion method

    Directory of Open Access Journals (Sweden)

    Abedini Reza

    2012-01-01

    Full Text Available In this study, asymmetric pure CA and CA/ TiO2 composite membranes were prepared via phase inversion by dispersing TiO2 nanopaticles in the CA casting solutions induced by immersion precipitation in water coagulation bath. TiO2 nanoparticles, which were synthesized by the sonochemical method, were added into the casting solution with different concentrations. Effects of TiO2 nanoparticles concentration (0 wt. %, 5wt.%, 10wt.%, 15wt.%, 20wt.% and 25wt.% and coagulation bath temperature (CBT= 25°C, 50°C and 75°C on morphology, thermal stability and pure water flux (PWF of the prepared membranes were studied and discussed. Increasing TiO2 concentration in the casting solution film along with higher CBT resulted in increasing the membrane thickness, water content (WC, membrane porosity and pure water flux (PWF, also these changes facilitate macrovoids formation. Thermal gravimetric analysis (TGA shows that thermal stability of the composite membranes were improved by the addition of TiO2 nanopaticles. Also TGA results indicated that increasing CBT in each TiO2 concentration leads to the decreasing of decomposition temperature (Td of hybrid membranes.

  7. Changes in carotenoids during processing and storage of pumpkin puree.

    Science.gov (United States)

    Provesi, João Gustavo; Dias, Carolinne Odebrecht; Amante, Edna Regina

    2011-09-01

    Changes in the contents of carotenoids and their true retentions (% TR) during the production of puree of Cucurbita moschata 'Menina Brasileira' and of Cucurbita maxima 'Exposição' pumpkins and the stability of such compounds during 180days of storage were monitored by liquid chromatography coupled with a photodiode array detector. Cooking caused higher losses than commercial sterilisation. High losses of xanthophylls such as lutein and violaxanthin were noted during processing and storage of pumpkin puree. Such losses show the low stability of these compounds. The major carotenoids, pro-vitamin A carotenes, namely, α-carotene and all-trans-β-carotene for C. moschata 'Menina Brasileira' and all-trans-β-carotene for C. maxima 'Exposição' obtained high retentions (>75%) after processing. A slight degree of isomerisation of β-carotene was noted in the puree samples, but with low concentrations of cis-isomers. Storage for 180days did not significantly affect (P⩽0.05) the concentrations of these carotenoids. Copyright © 2011 Elsevier Ltd. All rights reserved.

  8. The Electronic Properties of O-Doped Pure and Sulfur Vacancy-Defect Monolayer WS₂: A First-Principles Study.

    Science.gov (United States)

    Wang, Weidong; Bai, Liwen; Yang, Chenguang; Fan, Kangqi; Xie, Yong; Li, Minglin

    2018-01-31

    Based on the density functional theory (DFT), the electronic properties of O-doped pure and sulfur vacancy-defect monolayer WS₂ are investigated by using the first-principles method. For the O-doped pure monolayer WS₂, four sizes (2 × 2 × 1, 3 × 3 × 1, 4 × 4 × 1 and 5 × 5 × 1) of supercell are discussed to probe the effects of O doping concentration on the electronic structure. For the 2 × 2 × 1 supercell with 12.5% O doping concentration, the band gap of O-doped pure WS₂ is reduced by 8.9% displaying an indirect band gap. The band gaps in 3 × 3 × 1 and 4 × 4 × 1 supercells are both opened to some extent, respectively, for 5.55% and 3.13% O doping concentrations, while the band gap in 5 × 5 × 1 supercell with 2.0% O doping concentration is quite close to that of the pure monolayer WS₂. Then, two typical point defects, including sulfur single-vacancy (V S ) and sulfur divacancy (V 2S ), are introduced to probe the influences of O doping on the electronic properties of WS₂ monolayers. The observations from DFT calculations show that O doping can broaden the band gap of monolayer WS₂ with V S defect to a certain degree, but weaken the band gap of monolayer WS₂ with V 2S defect. Doping O element into either pure or sulfur vacancy-defect monolayer WS₂ cannot change their band gaps significantly, however, it still can be regarded as a potential method to slightly tune the electronic properties of monolayer WS₂.

  9. Experimental research on microhardness and wear resistances of pure Cu subjected to surface dynamic plastic deformation by ultrasonic impact

    Science.gov (United States)

    Chen, Zhaoxia; He, Yangming

    2018-04-01

    Dynamic plastic deformation (DPD) has been induced in the surface of pure Cu by ultrasonic impact treating (UIT) with the varied impact current and coverage percentage. The microstructures of the treated surface were analyzed by a scanning electron microscope (SEM). And the wear resistance of pure Cu was experimentally researched both with the treated and untreated specimens. The effect of DPD on the hardness was also investigated using microhardness tester. The results show that the grains on the top surfaces of pure Cu are highly refined. The maximum depth of the plastic deformation layer is approximately 1400 µm. The larger the current and coverage percentage, the greater of the microhardness and wear resistance the treated surface layer of pure Cu will be. When the impact current is 2 A and coverage percentage is 300%, the microhardness and wear resistance of the treated sample is about 276.1% and 68.8% higher than that of the untreated specimen, respectively. But the properties of the treated sample deteriorate when the UIT current is 3 A and the coverage percentage is 300% because of the formation of a new phase forms in the treated surface.

  10. Effect of Al-5Ti-0.62C-0.2Ce Master Alloy on the Microstructure and Tensile Properties of Commercial Pure Al and Hypoeutectic Al-8Si Alloy

    Directory of Open Access Journals (Sweden)

    Wanwu Ding

    2017-06-01

    Full Text Available Al-5Ti-0.62C-0.2Ce master alloy was synthesized by a method of thermal explosion reaction in pure molten aluminum and used to modify commercial pure Al and hypoeutectic Al-8Si alloy. The microstructure and tensile properties of commercial pure Al and hypoeutectic Al-8Si alloy with different additions of Al-5Ti-0.62C-0.2Ce master alloy were investigated. The results show that the Al-5Ti-0.62C-0.2Ce alloy was composed of α-Al, granular TiC, lump-like TiAl3 and block-like Ti2Al20Ce. Al-5Ti-0.62C-0.2Ce master alloy (0.3 wt %, 5 min can significantly refine macro grains of commercial pure Al into tiny equiaxed grains. The Al-5Ti-0.62C-0.2Ce master alloy (0.3 wt %, 30 min still has a good refinement effect. The tensile strength and elongation of commercial pure Al modified by the Al-5Ti-0.62C-0.2Ce master alloy (0.3 wt %, 5 min increased by roughly 19.26% and 61.83%, respectively. Al-5Ti-0.62C-0.2Ce master alloy (1.5 wt %, 10 min can significantly refine both α-Al grains and eutectic Si of hypoeutectic Al-8Si alloy. The dendritic α-Al grains were significantly refined to tiny equiaxed grains. The morphology of the eutectic Si crystals was significantly refined from coarse needle-shape or lath-shape to short rod-like or grain-like eutectic Si. The tensile strength and elongation of hypoeutectic Al-8Si alloy modified by the Al-5Ti-0.62C-0.2Ce master alloy (1.5 wt %, 10 min increased by roughly 20.53% and 50%, respectively. The change in mechanical properties corresponds to evolution of the microstructure.

  11. Antimicrobial activity of pure platelet-rich plasma against microorganisms isolated from oral cavity

    OpenAIRE

    Drago, Lorenzo; Bortolin, Monica; Vassena, Christian; Taschieri, Silvio; Del Fabbro, Massimo

    2013-01-01

    Background Autologous platelet concentrates (PCs) have been extensively used in a variety of medical fields to promote soft and hard tissue regeneration. The significance behind their use lies in the abundance of growth factors in platelets ?-granules that promotes wound healing. In addition, antibacterial properties of PCs against various bacteria have been recently pointed out. In this study, the antimicrobial effect of pure platelet-rich plasma (P-PRP) was evaluated against oral cavity mic...

  12. Positron prevacancy effects in pure annealed metals

    International Nuclear Information System (INIS)

    Smedskjaer, L.C.

    1981-06-01

    The low-temperature prevacancy effects sometimes observed with positrons in well-annealed high-purity metals are discussed. It is shown that these effects are not experimental artifacts, but are due to trapping of the positrons. It is suggested that dislocations are responsible for these trapping effects. 46 references, 5 figures

  13. Investigation on the Enhanced Oxidation of Ferritic/Martensitic Steel P92 in Pure Steam

    Directory of Open Access Journals (Sweden)

    Juntao Yuan

    2014-04-01

    Full Text Available Oxidation of ferritic/martensitic steel P92 was investigated in pure oxygen and in pure steam at 600–800 °C by thermogravimetric analysis (TGA, optical microscopy (OM, scanning electron microscopy (SEM, and X-ray diffraction (XRD. The results showed that the oxidation of P92 was significantly enhanced and multilayer scale with an outer iron oxides layer formed in pure steam. At 700 °C, the gas switch markedly influenced the scaling kinetics and scale microstructure. It was supposed that the higher affinity of iron to steam would be attributed to the enhanced oxidation of P92 in pure steam, and the much easier transport of hydroxyl would account for the significant difference induced by gas switch.

  14. Deformation and recrystallization textures in commercially pure aluminum

    DEFF Research Database (Denmark)

    Hansen, Niels; Juul Jensen, Dorte

    1986-01-01

    The deformation and recrystallization textures of commercially pure aluminum (99.6 pct) containing large intermetallic particles (FeAl3) are measured by neutron diffraction, and the orientation distribution functions (ODF’s) are calculated. Sample parameters are the initial grain size (50 and 350...

  15. Covariant map between Ramond-Neveu-Schwarz and pure spinor formalisms for the superstring

    International Nuclear Information System (INIS)

    Berkovits, Nathan

    2014-01-01

    A covariant map between the Ramond-Neveu-Schwarz (RNS) and pure spinor formalisms for the superstring is found which transforms the RNS and pure spinor BRST operators into each other. The key ingredient is a dynamical twisting of the ten spin-half RNS fermions into five spin-one and five spin-zero fermions using bosonic pure spinors that parameterize an SO(10)/U(5) coset. The map relates massless vertex operators in the two formalisms, and gives a new description of Ramond states which does not require spin fields. An argument is proposed for relating the amplitude prescriptions in the two formalisms

  16. Quadratic Plus Linear Operators which Preserve Pure States of Quantum Systems: Small Dimensions

    International Nuclear Information System (INIS)

    Saburov, Mansoor

    2014-01-01

    A mathematical formalism of quantum mechanics says that a pure state of a quantum system corresponds to a vector of norm 1 and an observable is a self-adjoint operator on the space of states. It is of interest to describe all linear or nonlinear operators which preserve the pure states of the system. In the linear case, it is nothing more than isometries of Hilbert spaces. In the nonlinear case, this problem was open. In this paper, in the small dimensional spaces, we shall describe all quadratic plus linear operators which preserve pure states of the quantum system

  17. Accelerated Generation of Selfed Pure Line Plants for Gene Identification and Crop Breeding

    Directory of Open Access Journals (Sweden)

    Guijun Yan

    2017-10-01

    Full Text Available Production of pure lines is an important step in biological studies and breeding of many crop plants. The major types of pure lines for biological studies and breeding include doubled haploid (DH lines, recombinant inbred lines (RILs, and near isogenic lines (NILs. DH lines can be produced through microspore and megaspore culture followed by chromosome doubling while RILs and NILs can be produced through introgressions or repeated selfing of hybrids. DH approach was developed as a quicker method than conventional method to produce pure lines. However, its drawbacks of genotype-dependency and only a single chance of recombination limited its wider application. A recently developed fast generation cycling system (FGCS achieved similar times to those of DH for the production of selfed pure lines but is more versatile as it is much less genotype-dependent than DH technology and does not restrict recombination to a single event. The advantages and disadvantages of the technologies and their produced pure line populations for different purposes of biological research and breeding are discussed. The development of a concept of complete in vitro meiosis and mitosis system is also proposed. This could integrate with the recently developed technologies of single cell genomic sequencing and genome wide selection, leading to a complete laboratory based pre-breeding scheme.

  18. Strength tests of thin-walled elliptic duralumin cylinders in pure bending and in combined pure bending and torsion

    Science.gov (United States)

    Lundquist, Eugene E; Stowell, Elbridge Z

    1942-01-01

    An analysis is presented of the results of tests made by the Massachusetts Institute of Technology and by the National Advisory Committee for Aeronautics on an investigation of the strength of thin-walled circular and elliptic cylinders in pure bending and in combined torsion and bending. In each of the loading conditions, the bending moments were applied in the plane of the major axis of the ellipse.

  19. On Pure and (approximate) Strong Equilibria of Facility Location Games

    DEFF Research Database (Denmark)

    Hansen, Thomas Dueholm; Telelis, Orestis A.

    2008-01-01

    We study social cost losses in Facility Location games, where n selfish agents install facilities over a network and connect to them, so as to forward their local demand (expressed by a non-negative weight per agent). Agents using the same facility share fairly its installation cost, but every...... agent pays individually a (weighted) connection cost to the chosen location. We study the Price of Stability (PoS) of pure Nash equilibria and the Price of Anarchy of strong equilibria (SPoA), that generalize pure equilibria by being resilient to coalitional deviations. For unweighted agents on metric...

  20. Production of Purely Gravitational Dark Matter

    OpenAIRE

    Ema, Yohei; Nakayama, Kazunori; Tang, Yong

    2018-01-01

    In the purely gravitational dark matter scenario, the dark matter particle does not have any interaction except for gravitational one. We study the gravitational particle production of dark matter particle in such a minimal setup and show that correct amount of dark matter can be produced depending on the inflation model and the dark matter mass. In particular, we carefully evaluate the particle production rate from the transition epoch to the inflaton oscillation epoch in a realistic inflati...

  1. Preparation of pure phenols from tars

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, J

    1933-02-07

    A process is disclosed for the preparation of pure phenols from brown coal tar, shale tar, or primary tar, characterized in that the raw oil obtained from the tar is carefully fractionated, in a suitable way without or with a slight pressure decrease, or before the fractionation the raw oil is heated to free the prepared phenolate solution from impurities after successful oxidation by passing in steam at a temperature between 100 and 120/sup 0/C.

  2. Experimental study of negative corona discharge in pure carbon dioxide and its mixtures with oxygen

    International Nuclear Information System (INIS)

    Mikoviny, T; Kocan, M; Matejcik, S; Mason, N J; Skalny, J D

    2004-01-01

    The products of a negative corona discharge in both pure CO 2 and mixtures of CO 2 + O 2 have been studied using a coaxial cylindrical electrode geometry with particular emphasis on the production of ozone. The discharge current in pure CO 2 was found to be highly sensitive to the presence of trace concentrations of molecular oxygen and to changes in the flow speed through the discharge. The effect of dissociative electron attachment to ozone on the discharge current was studied by measurements of ozone and CO production. The ozone concentration increases monotonically with increasing content of oxygen in the mixture with carbon dioxide, whereas the CO concentration exhibits a flat maximum for oxygen concentrations of around 4%. A simple kinetic model of the dominant chemical processes is described and compared with the experimental results

  3. Interconversion of pure Gaussian states requiring non-Gaussian operations

    Science.gov (United States)

    Jabbour, Michael G.; García-Patrón, Raúl; Cerf, Nicolas J.

    2015-01-01

    We analyze the conditions under which local operations and classical communication enable entanglement transformations between bipartite pure Gaussian states. A set of necessary and sufficient conditions had been found [G. Giedke et al., Quant. Inf. Comput. 3, 211 (2003)] for the interconversion between such states that is restricted to Gaussian local operations and classical communication. Here, we exploit majorization theory in order to derive more general (sufficient) conditions for the interconversion between bipartite pure Gaussian states that goes beyond Gaussian local operations. While our technique is applicable to an arbitrary number of modes for each party, it allows us to exhibit surprisingly simple examples of 2 ×2 Gaussian states that necessarily require non-Gaussian local operations to be transformed into each other.

  4. Analysis of the temperature and thermal stress in pure tungsten monoblock during heat loading and the influences of alloying and dispersion strengthening on these responses

    Energy Technology Data Exchange (ETDEWEB)

    Fukuda, Makoto, E-mail: makoto.fukuda@qse.tohoku.ac.jp [Tohoku University, 6-6-01-2 Aramaki-aza Aoba, Aobaku, Sendai, 980-8579 (Japan); Nogami, Shuhei; Guan, Wenhai; Hasegawa, Akira [Tohoku University, 6-6-01-2 Aramaki-aza Aoba, Aobaku, Sendai, 980-8579 (Japan); Muroga, Takeo [National Institute for Fusion Science, 322-6 Oroshi-cho, Gifu, 509-5292 (Japan)

    2016-06-15

    Highlights: • The heat load response of pure W and its alloys monoblock was investigated by FEA. • The effect of alloying on heat load response of W was not clearly observed. • The possibility of cracking during cooling phase after heat load was suggested. • The effects of recrystallization and irradiation embrittlement were discussed. • W alloys will show better reliability than pure W during fusion reactor operation. - Abstract: The effects of 3% Re addition and K-bubble dispersion on temperature and stress values and the distributions thereof in a W monoblock during heat loading were investigated using finite element analysis. K-doped W-3%Re exhibited the highest recrystallization resistance but showed a higher surface temperature than pure W or K-doped W during the heat loading. The effect of K-bubble dispersion and 3% Re addition on thermal stress distribution during heat loading was not clearly observed, and residual tensile stress after heat loading, which could possibly cause cracking, was observed at the top surfaces of all materials. Because of the higher strength and temperature at which recrystallization starts for the K-doped W-3%Re and K-doped W, the probability of crack formation at the top surface might be lower compared to that in pure W. The improvement in the material properties and resistance to crack initiation and propagation in W during cyclic heat loading is crucial for the design and development of plasma-facing components. This work suggests possibility of the crack formation in a pure W monoblock in the cooling phase after a 20 MW/m{sup 2} heat loading cycle and the effectiveness of K-bubble dispersion and Re addition for improving the heat loading resistance of monoblock W.

  5. The use of pure and impure placebo interventions in primary care - a qualitative approach

    Directory of Open Access Journals (Sweden)

    Senn Oliver

    2011-03-01

    Full Text Available Abstract Background Placebos play an important role in clinical trials and several surveys have shown that they are also common in daily practice. Previous research focused primarily on the frequency of placebo use in outpatient care. Our aim was to explore physicians' views on the use of placebos in daily practice, whereby distinction was made between pure placebos (substances with no pharmacological effect, e.g. sugar pills and impure placebos (substances with pharmacological effect but not on the condition being treated, e.g. antibiotics in viral infections or vitamins. Methods We performed semi-structured interviews with a sample of twelve primary care physicians (PCPs. The interview addressed individual definitions of a placebo, attitudes towards placebos and the participants' reasons for prescribing them. The interviews were transcribed and analysed using qualitative content analysis. Results The definition of a placebo given by the majority of the PCPs in our study was one which actually only describes pure placebos. This definition, combined with the fact that most impure placebos were not regarded as placebos at all, means that most of the participating PCPs were not aware of the extent to which placebos are used in daily practice. The PCPs stated that they use placebos (both pure and impure mainly in the case of non-severe diseases for which there was often no satisfactory somatic explanation. According to the PCPs, cases like this are often treated by complementary and alternative therapies and these, too, are associated with placebo effects. However, all PCPs felt that the ethical aspects of such treatment were unclear and they were unsure as to how to communicate the use of placebos to their patients. Most of them would appreciate ethical guidelines on how to deal with this issue. Conclusions Many PCPs seem to be unaware that some of the drugs they prescribe are classified as impure placebos. Perceptions of effectiveness and doubts

  6. Thermoluminescence and recovery processes in pure and doped NaCl after 20 K irradiation

    International Nuclear Information System (INIS)

    Lopez, F.J.; Aguilar, M.; Jaque, F.; Agullo-Lopez, F.

    1980-01-01

    The thermoluminescence (TL) spectra after X-ray irradiation at 20 K have been investigated for pure as well as divalent cation doped NaCl. The F-centre decay has also been determined in pure and Ca and Mg doped NaCl for comparison purposes. A clear decrease in F-centre concentration appears to correlate with glow peaks at 44 and 50 K for pure and Ca-doped samples. Main glow peak appearing at 69 K is not associated to any appreciable F-centre decay step. Below liquid nitrogen temperature (LNT) all peaks show both σ and π exciton emission bands. Above LNT, the glow peaks for doped samples show the σ emission together with another band at 410 nm, whereas pure samples still present the intrinsic emission bands. (author)

  7. Energetics and optical properties of 6-dimensional rotating black hole in pure Gauss-Bonnet gravity

    International Nuclear Information System (INIS)

    Abdujabbarov, Ahmadjon; Ahmedov, Bobomurat; Atamurotov, Farruh; Dadhich, Naresh; Stuchlik, Zdenek

    2015-01-01

    We study physical processes around a rotating black hole in pure Gauss-Bonnet (GB) gravity. In pure GB gravity, the gravitational potential has a slower fall-off as compared to the corresponding Einstein potential in the same dimension. It is therefore expected that the energetics of a pure GB black hole would be weaker, and our analysis bears out that the efficiency of energy extraction by the Penroseprocess is increased to 25.8 % and the particle acceleration is increased to 55.28 %; the optical shadow of the black hole is decreased. These are in principle distinguishing observable features of a pure GB black hole. (orig.)

  8. Pasteurization of strawberry puree using a pilot plant pulsed electric fields (PEF) system

    Science.gov (United States)

    The processing of strawberry puree by pulsed electric fields (PEF) in a pilot plant system has never been evaluated. In addition, a method does not exist to validate the exact number and shape of the pulses applied during PEF processing. Both buffered peptone water (BPW) and fresh strawberry puree (...

  9. Effect of baking and steaming on physicochemical and thermal properties of sweet potato puree preserved by freezing and freeze-drying

    Directory of Open Access Journals (Sweden)

    Bernarda Svrakačić

    2016-01-01

    Full Text Available Thermal treatments could be one of the hurdles in applications of sweet potato purees for food different products formulation. Sweet potato purees (SPP were prepared from raw, baked and steamed roots and they were preserved by freezing and freeze-drying. The effects of baking and steaming on thermal properties (melting temperature-Tm, melting transition energy - ΔH, and glass transition temperatures - Tg of sweet potato (cultivar Beauregard, were measured by means of a Differential scanning calorimetry (DSC. The SPP made from baked roots had higher total and soluble solids (20.32 and 18.95%, respectively than SPP made from raw and steamed roots. It can be also noticed that starch content was reduced by steaming and baking which reflected on amount of total and reducing sugars. The increase of reducing sugars level in baked SPP for 3.78% and steamed for 0.86% SPP was the result of yielding the maltose. The chemical changes of SPP also influenced the thermal behavior such that SPP prepared from baked sweet potato roots had the lowest initial freezing point (-2.80 °C followed by SPP prepared from steamed (-2.63 °C and raw (-0.71 °C roots. The highest energy for melting (transition was needed for SPP prepared from raw potato roots followed by steamed and baked roots, -103.79, -103.63, and -102.90 J/g, respectively. The glass transition in freeze-dried SPP prepared from raw roots was not detected. However, in the freeze-dried SPP prepared from baked and steamed roots the glass transition was detected in the range of 39 and 42 °C but with no significant difference (p > 0.05.

  10. Reflections on the pathogenesis of Down syndrome.

    Science.gov (United States)

    Opitz, J M; Gilbert-Barness, E F

    1990-01-01

    Present efforts to identify, isolate, and characterize in molecular terms the "consensus" segment of 21q sufficient to cause most of the major and some of the most characteristic minor manifestations of Down syndrome will soon provide answers to many questions. However, we think that a reductionist approach to explain the Down syndrome phenotype in a "linear" manner from the DNA sequence of the segment will be doomed to failure from the outset because of the open, complex, nonlinear, hierarchical nature of morphogenetic systems. Neo-Darwinism is under strong attack; most genetic changes accumulated over time may very well be of neutral effect, and detailed studies in several related groups of vertebrate species has shown that molecular and organismal evolution are largely independent of one another. It has been pointed out recently that biology lacks a theory of ontogenetic and phylogenetic development, and that a purely "genocentric" view of biology at the expense of the complexly hierarchical intrinsic epigenetic attributes of developmental systems is "out of focus with respect to ... biological organization and morphogenesis," and may be "a residue of nineteenth century romantic idealism." Down syndrome impresses us as a paradigm of increased developmental variability due to a deceleration of the rate of development (neoteny) with many anomalies of incomplete morphogenesis (vestigia), atavisms, increased morphometric variability with many decreased means, increased variances, and increased fluctuating asymmetry. These abnormalities, together with highly increased risk of prenatal death and postnatal morbidity, impaired growth, and abnormal CNS and gonadal structure and function characteristic of most aneuploidy syndromes, suggest to us that the pathogenesis of Down syndrome is best viewed in terms of the mechanisms of speciation. Transgenic experiment involving sequential or overlapping pieces of "the consensus segment" on distal 21q22.1-22.3 may help decide to

  11. Corrosion and hydrogen absorption of commercially pure zirconium in acid fluoride solutions

    International Nuclear Information System (INIS)

    Yokoyama, Ken’ichi; Yamada, Daisuke; Sakai, Jun’ichi

    2013-01-01

    Highlights: •Zirconium corrodes and absorbs hydrogen in acid fluoride solutions. •Hydrogen thermal desorption is observed at 300–700 °C. •The resistance to hydrogen absorption of zirconium is higher than that of titanium. -- Abstract: The corrosion and hydrogen absorption of commercially pure zirconium have been investigated in acidulated phosphate fluoride (APF) solutions. Upon immersion in 2.0% APF solution of pH 5.0 at 25 °C, a granular corrosion product (Na 3 ZrF 7 ) deposits over the entire side surface of the specimen, thereby inhibiting further corrosion. In 0.2% APF solution, marked corrosion is observed from the early stage of immersion; no deposition of the corrosion product is observed by scanning electron microscopy. A substantial amount of hydrogen absorption is confirmed in both APF solutions by hydrogen thermal desorption analysis. The amount of absorbed hydrogen of the specimen immersed in the 2.0% APF solution is smaller than that in the 0.2% APF solution in the early stage of immersion. The hydrogen absorption behavior is not always consistent with the corrosion behavior. Hydrogen thermal desorption occurs in the temperature range of 300–700 °C for the specimen without the corrosion product. Under the same immersion conditions, the amount of absorbed hydrogen in commercially pure zirconium is smaller than that in commercially pure titanium as reported previously. The present results suggest that commercially pure zirconium, compared with commercially pure titanium, is highly resistant to hydrogen absorption, although corrosion occurs in fluoride solutions

  12. Study of Trehalose Addition on Aroma Retention in Dehydrated Strawberry Puree

    Directory of Open Access Journals (Sweden)

    Draženka Komes

    2003-01-01

    Full Text Available In order to improve the quality of dehydrated fruit products, the influence of the addition of two sugars (sucrose and trehalose on the retention of aroma components during dehydration of strawberry puree was investigated. Manual headspace solid-phase microextraction (SPME, containing polydimethylsiloxane coated fibre (100 μm coupled with gas chromatography (GC-FID and GC-MS was used for the analysis of the aroma of strawberry puree dehydrated by using freeze drying and foam-mat drying. The analytes identified included esters, carbonyl compounds, terpenoids, several alcohols and acids. The results obtained in this study give further insight into the mechanisms concerning the application of trehalose as flavouring additive, due to its ability to retain and preserve the fruit volatiles responsible for the characteristic flavour of fresh fruits during dehydration processes. The best retention of aroma components in dehydrated strawberry puree was obtained by trehalose addition when combined with freeze drying.

  13. Preparation of very pure active carbon

    International Nuclear Information System (INIS)

    Sloot, H.A. van der; Hoede, D.; Zonderhuis, J.; Meijer, C.

    1980-02-01

    The preparation of very pure active carbon is described. Starting from polyvinylidene chloride active carbon is prepared by carbonization in a nitrogen atmosphere, grinding, sieving and activation of the powder fraction with CO 2 at 950 0 to approximately 50% burn-off. The concentrations of trace and major elements are reduced to the ppb and ppm level, respectively. In the present set-up 100 g of carbon grains and approximately 50 g of active carbon powder can be produced weekly

  14. Pure spin current induced by adiabatic quantum pumping in zigzag-edged graphene nanoribbons

    International Nuclear Information System (INIS)

    Souma, Satofumi; Ogawa, Matsuto

    2014-01-01

    We show theoretically that pure spin current can be generated in zigzag edged graphene nanoribbons through the adiabatic pumping by edge selective pumping potentials. The origin of such pure spin current is the spin splitting of the edge localized states, which are oppositely spin polarized at opposite edges. In the proposed device, each edge of the ribbon is covered by two independent time-periodic local gate potentials with a definite phase difference, inducing the edge spin polarized current. When the pumping phase difference is opposite in sign between two edges, the total charge currents is zero and the pure edge spin current is generated

  15. Biosorpsi Tanaman Puring (Codiaeum variegatum Terhadap Emisi Timbal (Pb Pada Kendaraan Bermotor

    Directory of Open Access Journals (Sweden)

    Nur Amalia P

    2014-07-01

    Full Text Available Enhancement the motorized vehicle number will be potential for air pollution in the big cities. One of the pollutant which is resulted from burning process fuel is timbale (Pb metal. Alternative effort that is used to decrease the higher timbale (Pb metal pollutantmaterial is with manner biosorption use puring plant (codiaeumvariegatum.The aim of this research is to know the puring plantability in absorbs Pb metal. The treatment methodis used to sprinkling plant and without sprinkling and than directly exposure to plant with period 3,6 and 9 days. The result of research  that puring leaves ability can absorb Pb concentration metal between (1 until 1,5 ppm or 0,304 mg/Kg at nine days of period exposure, it order can be considered as biosorption agent Pb metal pollution.

  16. Depth concentrations of deuterium ions implanted into some pure metals and alloys

    International Nuclear Information System (INIS)

    Didyk, A.Yu.; Wisniewski, R.; Kitowski, K.; Wilczynska, T.; Hofman, A.; Kulikauskas, V.; Shiryaev, A.A.; Zubavichyus, Ya.V.

    2011-01-01

    Pure metals (Cu, Ti, Zr, V, Pd) and diluted Pd alloys (Pd-Ag, Pd-Pt, Pd-Ru, Pd-Rh) were implanted by 25-keV deuterium ions at fluences in the range (1.2-2.3) x 10 22 D + /m 2 . The post-treatment depth distributions of deuterium ions were measured 10 days and three months after the implantation by using Elastic Recoil Detection Analysis (ERDA) and Rutherford Backscattering (RBS). Comparison of the obtained results allowed us to make conclusions about relative stability of deuterium and hydrogen gases in pure metals and diluted Pd alloys. Very high diffusion rates of implanted deuterium ions from V and Pd pure metals and Pd alloys were observed. Small-angle X-ray scattering revealed formation of nanosized defects in implanted corundum and titanium

  17. Pure Jauch-Piron states on von Neumann algebras

    International Nuclear Information System (INIS)

    Hamhalter, J.

    1993-01-01

    We study Jauch-Piron states and two-valued measures on von Neumann algebra. We prove as the main result that, under some set-theoretical assumption, a pure state of a von Neumann algebra A not containing a central abelian portion is Jauch-Piron if and only if it is σ-additive. Moreover, we show that this result holds for type I factor indenpendently on the set-theoretical axiomatics. As a consequence we obtain a lucid characterization of pure Jauch-Piron states on von Neumann algebras acting on a Hilbert space with real-nonmeasurable dimension (this can be viewed as a generalization of the paper). We also characterize the von Neumann algebras whose logic of projections is Jauch-Piron. Finally, we prove that every two-valued measure on the projection logic of A, where A contains no type I 2 central portion, has to be concentrated at an abelian direct summand of A. (orig.)

  18. Microwave and hot air drying of garlic puree: drying kinetics and quality characteristics

    Science.gov (United States)

    İlter, Işıl; Akyıl, Saniye; Devseren, Esra; Okut, Dilara; Koç, Mehmet; Kaymak Ertekin, Figen

    2018-02-01

    In this study, the effect of hot air and microwave drying on drying kinetics and some quality characteristics such as water activity, color, optic index and volatile oil of garlic puree was investigated. Optic index representing browning of the garlic puree increased excessively with an increase in microwave power and hot air drying temperature. However, volatile oil content of the dried samples was decreased by increasing of temperature and microwave power. By increasing drying temperature (50, 60 and 70 °C) and microwave power (180, 360 and 540 W), the drying time decreased from 8.5 h to 4 min. In order to determine the kinetic parameters, the experimental drying data were fitted to various semi-empirical models beside 2nd Fick's diffusion equation. Among them, the Page model gave a better fit for microwave-drying, while Logarithmic model gave a better fit for hot air drying. By increasing the microwave power and hot air drying temperature, the effective moisture diffusivity, De values ranged from 0.76×10-8 to 2.85×10-8 m2/s and from 2.21×10-10 to 3.07×10-10 m2/s, respectively. The activation energy was calculated as 20.90 kJ/mol for hot air drying and 21.96 W/g for microwave drying using an Arrhenius type equation.

  19. Faithful teleportation with arbitrary pure or mixed resource states

    International Nuclear Information System (INIS)

    Zhao Mingjing; Fei Shaoming; Wang Zhixi; Li Zongguo; Lijost Xianqing

    2011-01-01

    We study faithful teleportation systematically with arbitrary entangled states as resources. The necessary conditions of mixed states to complete perfect teleportation are proved. Based on these results, the necessary and sufficient conditions of faithful teleportation of an unknown state |φ) in C d with an entangled resource ρ in C m otimes C d and C d otimes C n are derived. It is shown that for ρ in C m otimes C d , ρ must be a maximally entangled state, while for ρ in C d otimes C n , ρ must be a pure maximally entangled state. Moreover, we show that the sender's measurements must be all projectors of maximally entangled pure states. The relations between the entanglement of the formation of the resource states and faithful teleportation are also discussed.

  20. Spectrophotometric determination of pizotefin maleate in pure form ...

    African Journals Online (AJOL)

    Two simple, quick and sensitive methods were described for the spectrophotometric determination of pizotefin maleate (PZT) either in pure form or pharmaceutical form (tablets). The methods were based on the reaction of pizotefin maleate as 'n' electron donor with chloranilic acid (p-CLA) and 7,7,8 ...