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Sample records for proximal development vygotsky

  1. How Instruction Influences Conceptual Development: Vygotsky's Theory Revisited

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    Clarà, Marc

    2017-01-01

    Although current interpretations of Vygotsky's theory largely assume that instruction pushes development, the issue of how this occurs has yet to be clarified. For example, the notion of "zone of proximal development" has aroused strong disagreement, and the common conceptualization of the notion of "nonspontaneous concept" has…

  2. A Comparative Study of Vygotsky's Perspectives on Child Language Development with Nativism and Behaviorism

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    Dastpak, Mehdi; Behjat, Fatemeh; Taghinezhad, Ali

    2017-01-01

    This study aimed at investigating the similarities and differences between Vygotsky's perspectives on child language development with nativism and behaviorism. Proposing the idea of the Zone of Proximal Development, Vygotsky emphasized the role of collaborative interaction, scaffolding, and guided participation in language learning. Nativists, on…

  3. Art form as an object of cognitive modeling (towards development of Vygotsky`s semiotic model)

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    Dmitriev, V. [Oklahoma State Univ. (United States); Perlovsky, L.I.

    1996-12-31

    We suggest a further development of Vygotsky`s esthetic-semiotic model. First, we discuss Vygotsky`s model originally developed for the analysis of Ivan Bunin`s story {open_quotes}Light Breath{close_quotes}. Vygotsky analyzes formal methods used by Bunin to achieve a specific esthetic effect of {open_quote}lightness{close_quotes} while describing {open_quotes}dirty{close_quotes} events of everyday life. According to Vygotsky, this effect is achieved by ordering of events in a non-linear fashion. Vygotsky creams an airy pattern of smooth lines connecting events of story that he first orders linearly in time. And, he insists that this airy pattern creates an impression of airy lightness. In the language of semiotics, the esthetic effect is created by a specific structural organization of signs. Second, we present our critique of Vygotsky`s model. Although, we do not agree with Vygotsky`s sometimes moralistic judgements, and we consider the dynamics between inner personal values and received moral values to be more complicated than implied in his judgements, our critique in this paper is limited to the structure of his semiotic model. We emphasize that Vygotsky`s model does not explicitly account for a hierarchy of multiple levels of semiotic analysis. His analysis regularly slips from one level to another: (1) a lever of cognitive perception by a regular reader is confused with a level of creative genius of a writer; (2) {open_quotes}open{close_quotes} time of real world is mixed up with {open_quote}closed{close_quote} time of the story; (3) events are not organized by the hierarchy of their importance, nor in real world, nor in the inner model of the personages, nor in the story.

  4. Revisioning Vygotsky.

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    Capps, Douglas

    To clarify the relevance of Russian psychologist, literary critic, philologist, and educational theorist Lev S. Vygotsky's research to composition theory necessitates an examination of his account of the development of inner and oral speech. Vygotsky argued that the acquisition and development of oral speech is due to its function: it is primarily…

  5. L.S. Vygotsky's Principle "One Step in Learning — A Hundred Steps in Development": In Search of Evidence

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    V.K. Zaretsky

    2015-10-01

    Full Text Available On the basis of L.S. Vygotsky's published works the paper attempts to trace the dynamics of his concepts of child development and to provide evidence supporting Vygotsky's statement that one step in learning equals a hundred in development, which is one of the key principles of culturalhistorical theory in its application to child development. This statement is put in a row with two other major principles: one arguing that learning precedes development and the other referring to the zone of proximal development. The paper outlines a multivector model of the zone of proximal development as one of the conceptual tools of the reflective and activity approach to helping children overcome learning difficulties and promoting their development. The paper also describes a case study in which an orphan child with a disability received psychological and educational support that obviously contributed to the child's development. It is argued that L.S. Vygotsky's idea of the specific relationship between learning and development has fundamental theoretical and practical implications, in particular, for working with children with special needs

  6. Scaffolding Critical Thinking in the Zone of Proximal Development

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    Wass, Rob; Harland, Tony; Mercer, Alison

    2011-01-01

    This paper explores student experiences of learning to think critically. Twenty-six zoology undergraduates took part in the study for three years of their degree at the University of Otago, New Zealand. Vygotsky's developmental model of the Zone of Proximal Development (ZPD) provided a framework as we examined how critical thinking was developed.…

  7. Observing Complex Systems Thinking in the Zone of Proximal Development

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    Danish, Joshua; Saleh, Asmalina; Andrade, Alejandro; Bryan, Branden

    2017-01-01

    Our paper builds on the construct of the zone of proximal development (ZPD) (Vygotsky in Mind in society: the development of higher psychological processes, Harvard University Press, Cambridge, 1978) to analyze the relationship between students' answers and the help they receive as they construct them. We report on a secondary analysis of…

  8. Sharpening a Tool for Teaching: The Zone of Proximal Development

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    Wass, Rob; Golding, Clinton

    2014-01-01

    Vygotsky's Zone of Proximal Development (ZPD) provides an important understanding of learning, but its implications for teachers are often unclear or limited and could be further explored. We use conceptual analysis to sharpen the ZPD as a teaching tool, illustrated with examples from teaching critical thinking in zoology. Our conclusions are…

  9. Vigostsky's formulations on ZDP - Zone of Proximal Development

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    José Moysés Alves

    2005-06-01

    Full Text Available The zone of proximal development (ZPD is, probably, the most known concept from Vygotsky's theory. And has been much discussed recently. Hoping to contribute for the understanding of this contemporary debate, we focus on recurrent themes in Vygotsky's writings. We read ten texts of his where he constructed the concept of ZPD. We have through the reading summarized his formulations about the following topics: criticism to the traditional diagnostic; explicit definitions of ZPD's concept; redefinition of imitation's concept; ZPD and pretend play; ZPD and the interaction between development and learning; ZPD and the interaction among daily and scientific concepts; practical value and theoretical value of ZPD's concept

  10. Science Teachers' Conceptual Growth within Vygotsky's Zone of Proximal Development.

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    Jones, M. Gail; Rua, Melissa J.; Carter, Glenda

    1998-01-01

    Examines how science teachers' (n=14) knowledge of science and science pedagogy changed after participation in a constructivist-based methods course. More-experienced teachers were paired with less-experienced teachers, and pre- and post-instructional concept maps, journals, portfolios, and transcripts revealed that, within the zone of proximal…

  11. Adult and Child Development in the Zone of Proximal Development: Socratic Dialogue in a Playworld

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    Ferholt, Beth; Lecusay, Robert

    2010-01-01

    This article analyses adult and child development in the zone of proximal development in an educational practice based in Vygotsky's theories of play: the playworld educational practice. The playworld educational practice is a central component of a Scandinavian play pedagogy that promotes shared responsibility amongst adults and children for…

  12. 'Philosophy for children' as creating the zone of proximal development

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    Pešić Jelena

    2014-01-01

    Full Text Available In this paper, we analyze the conception, objectives and methodology of the 'Philosophy for Children', a programme aimed at fostering critical thinking in children aged five to eighteen. The analysis is based on the key concepts and principles of Vygotsky's developmental theory. We believe that discussing the manner in which these concepts and principles are embodied in one successful and influential thinking skills programme could enhance the concept of the zone of proximal development, as well as our understanding of the processes through which cognitive competencies are co-constructed. The practical relevance of the analysis refers to a controversial issue of whether higher-order cognitive skills can be fostered at a young age. The analysis reveals that Lipman has creatively applied Vygotsky's idea of the formative role of spontaneous and scientific concepts interaction, thus focusing on the metacognitive development. Consequently, the methodological procedures are language-based, using the narrative, dialogical and rational forms of discourse as mediation tools for developing the skills of logical reasoning and critical thinking. Philosophical novels, as an innovative educational genre, exemplify Lipman's contribution to enriching the concept of direct cultural interaction, which has generally been less studied within the socio-cultural approach. The analysis of gradual transformation of group discussion, from monological and mostly anegdotical, through genuine dialogical exchanges, to mastering the procedures and skills of critical dialogue, is one of the most plausible accounts of Vygotsky's genetic law. The specific role of the teacher, who indirectly guides the discussion through the use of Socratic questioning, expands the concept of finely tuned support and the strategies for creating the zone of proximal development in educational context.

  13. Group Problem Solving as a Zone of Proximal Development activity

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    Brewe, Eric

    2006-12-01

    Vygotsky described learning as a process, intertwined with development, which is strongly influenced by social interactions with others that are at differing developmental stages.i These interactions create a Zone of Proximal Development for each member of the interaction. Vygotsky’s notion of social constructivism is not only a theory of learning, but also of development. While teaching introductory physics in an interactive format, I have found manifestations of Vygotsky’s theory in my classroom. The source of evidence is a paired problem solution. A standard mechanics problem was solved by students in two classes as a homework assignment. Students handed in the homework and then solved the same problem in small groups. The solutions to both the group and individual problem were assessed by multiple reviewers. In many cases the group score was the same as the highest individual score in the group, but in some cases, the group score was higher than any individual score. For this poster, I will analyze the individual and group scores and focus on three groups solutions and video that provide evidence of learning through membership in a Zone of Proximal Development. Endnotes i L. Vygotsky -Mind and society: The development of higher mental processes. Cambridge, MA: Harvard University Press. (1978).

  14. Implementing the Zone of Proximal Development: From the Pedagogical Experiment to the Developmental Education System of Leonid Zankov

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    Guseva, Liudmila G.; Solomonovich, Mark

    2017-01-01

    This article overviews the theoretical and applied works of the psychologist and pedagogue Leonid Zankov. Zankov's model of teaching is based on Vygotsky's theory that appropriate teaching methods stimulate cognitive development, whose core notion is the Zone of Proximal Development. This educational psychology research was verified by large scale…

  15. Vygotsky in applied neuropsychology

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    Glozman J. M.

    2016-12-01

    Full Text Available The aims of this paper are: 1 to show the role of clinical experience for the theoretical contributions of L.S. Vygotsky, and 2 to analyze the development of these theories in contemporary applied neuropsychology. An analysis of disturbances of mental functioning is impossible without a systemic approach to the evidence observed. Therefore, medical psychology is fundamental for forming a systemic approach to psychology. The assessment of neurological patients at the neurological hospital of Moscow University permitted L.S. Vygotsky to create, in collaboration with A.R. Luria, the theory of systemic dynamic localization of higher mental functions and their relationship to cultural conditions. In his studies of patients with Parkinson’s disease, Vygotsky also set out 3 steps of systemic development: interpsychological, then extrapsychological, then intrapsychological. L.S. Vygotsky and A.R. Luria in the late 1920s created a program to compensate for the motor subcortical disturbances in Parkinson’s disease (PD through a cortical (visual mediation of movements. We propose to distinguish the objective mediating factors — like teaching techniques and modalities — from subjective mediating factors, like the individual’s internal representation of his/her own disease. The cultural-historical approach in contemporary neuropsychology forces neuropsychologists to re-analyze and re-interpret the classic neuropsychological syndromes; to develop new assessment procedures more in accordance with the patient’s conditions of life; and to reconsider the concept of the social brain as a social and cultural determinant and regulator of brain functioning. L.S. Vygotsky and A.R. Luria proved that a defect interferes with a child’s appropriation of his/her culture, but cultural means can help the child overcome the defect. In this way, the cultural-historical approach became, and still is, a methodological basis for remedial education.

  16. Using the Internet as a Zone of Proximal Development for the Teaching of Indirect Speech: A Vygotskian Approach.

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    Alm-Lequeux, Antoine

    2001-01-01

    Discusses a theoretical framework for Internet-enhanced German language instruction based on sociocultural aspects of second language acquisition theory and Vygotsky's educational concept of zone of proximal development. These principles are illustrated in an Internet-based work unit on the topic of journalism. (Author/VWL)

  17. Linguagem e atividade no desenvolvimento cognitivo: algumas reflexões sobre as contribuições de Vygotsky e Leontiev Language and activity in cognitive development: some reflections about the contributions of Vygotsky and Leontiev

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    Carolina Lampreia

    1999-01-01

    Full Text Available As noções de linguagem e atividade foram consideradas centrais para o estudo do desenvolvimento cognitivo por Vygotsky e Leontiev. Vygotsky queria analisar como a atividade prática contribui para a formação da consciência. Contudo, suas pesquisas permaneceram centradas na linguagem. Conseqüentemente, não ficou clara, em seu trabalho, a relação existente entre linguagem e atividade. Leontiev desenvolveu uma teoria cuja unidade de análise passou a ser a atividade. Mas não desenvolveu a análise do papel da linguagem. Assim, embora ambos tenham considerado a relevância desses dois aspectos do desenvolvimento cognitivo, nenhum dos dois os abordou simultaneamente. Por outro lado, as reflexões filosóficas do ‘segundo’ Wittgenstein a respeito da linguagem permitiram-lhe concebê-la como uma forma de ação não sendo possível separar atividade e linguagem. Juntando-se a autores com preocupações similares, esta perspectiva pode permitir elaborar uma abordagem eminentemente contextualista do desenvolvimento cognitivo inspirada nas formulações de Vygotsky e Leontiev. Mas é preciso analisar e discutir suas noções de linguagem e atividade no contexto da perspectiva wittgensteiniana.The notions of language and activity have been seen as of central importance to the study of cognitive development by L. S. Vygotsky and A. N. Leontiev. Vygotsky’s idea was to analyze how practical activity contributes to the development of consciousness. However, his studies concentrated on language and do not clarify the relationship between activity and language. Leontiev developed a theory in which activity is the unit of analysis but failed to carry out a thorough analysis of the role of language. Although Vygotsky and Leontiev considered the relevance of these two aspects of cognitive development, neither of them examined the two aspects simultaneously. In Wittgenstein’s philosophical reflections, language and activity can no longer be considered

  18. Threads: theory of Vygotsky to learning processes and child development in early childhood education mediated by toy construction

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    Fábio Tadeu Reina

    2016-05-01

    Full Text Available This article has the objectivity to point out some of the threads of the cultural historical theory of Vygotsky partner to the process of learning and development of children in early childhood education mediated by the construction of toys and games. In this direction, looking to approach the foundations of this theory in order to internalize the reader in his work in search of reflections and readings on the theme proposed here.

  19. Vygotsky's Crisis: Argument, context, relevance.

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    Hyman, Ludmila

    2012-06-01

    Vygotsky's The Historical Significance of the Crisis in Psychology (1926-1927) is an important text in the history and philosophy of psychology that has only become available to scholars in 1982 in Russian, and in 1997 in English. The goal of this paper is to introduce Vygotsky's conception of psychology to a wider audience. I argue that Vygotsky's argument about the "crisis" in psychology and its resolution can be fully understood only in the context of his social and political thinking. Vygotsky shared the enthusiasm, widespread among Russian leftist intelligentsia in the 1920s, that Soviet society had launched an unprecedented social experiment: The socialist revolution opened the way for establishing social conditions that would let the individual flourish. For Vygotsky, this meant that "a new man" of the future would become "the first and only species in biology that would create itself." He envisioned psychology as a science that would serve this humanist teleology. I propose that The Crisis is relevant today insofar as it helps us define a fundamental problem: How can we systematically account for the development of knowledge in psychology? I evaluate how Vygotsky addresses this problem as a historian of the crisis. Copyright © 2011 Elsevier Ltd. All rights reserved.

  20. Is Vygotsky Relevant? Vygotsky's Marxist Psychology

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    Packer, Martin J.

    2008-01-01

    This article explores the connections between Vygotsky's psychology and Marxism, arguing that his was a "Marxist psychology" in its "historical foundation": a specific conception of history. This conception of history is evident in Vygotsky's analysis and diagnosis of the crisis in psychology. The creation of a Marxist, general psychology was the…

  1. Reflexões sobre desenvolvimento humano e neuropsicologia na obra de Vigotski Reflexiones sobre el desarrollo humano y neuropsicología en Vygotsky Reflections on human development and neuropsychology in the Vygotsky' works

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    Joana de Jesus de Andrade

    2012-12-01

    el estudio de la neuropsicología y el desarrollo humano.The present text appears as a theoretical essay on the subject of human development as depicted in the work of Lev Vygotsky and approaches the implications of this issue for Neuropsychology as described in the work of Alexander Luria. This work was conducted on the basis of the complete works of Vygotsky in Spanish and the works of Vygotsky and Luria in the Portuguese language. Considerations about the functioning of the human brain, the concept of compensation, the disability studies, and the concept of Complex Functional System were selected as the focus of our research. Although numerous studies and different translations of the work of Vygotsky have a considerable impact and dissemination, especially in the fields of psychology and education, issues concerning neuropsychology have not had equal importance. In this context, this paper seeks to highlight the contributions and the fruitfulness of the work with regard to the originality of the author's ideas about the study of neuropsychology and human development.

  2. A dynamic systems model of basic developmental mechanisms : Piaget, Vygotsky, and beyond

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    van Geert, P

    1998-01-01

    A dynamic systems model is proposed on the basis of a general developmental mechanism adopted from the theories of J. Piaget and L. S. Vygotsky, more particularly a mechanism based on the concepts assimilation versus accommodation and actual development versus zone of proximal development. In the

  3. Vygotsky's Principle "One Step in Learning - One Hundred Steps In Development": From Idea To Practice

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    Zaretsky V.K.,

    2016-12-01

    Full Text Available The article reviews Lev Vygotsky’s published works to trace the evolution of his understanding of child development. The authors believe that his assumption that one step in learning may mean one hundred steps in development, is as important as the two other key postulates of the cultural-historical theory: the principle that learning precedes development and the concept of zone of proximal development. The authors provide a rationale for utilization of these assumptions in the practice of development-facilitating psychological and educational assistance. A mechanism of this learning-development relationship is hypothesized. The article outlines a multidimensional model of the zone of proximal development illustrating the above mechanism. This model is one of the conceptual tools of the Reflection and Activity Approach helping children overcome learning difficulties and promoting their development. Having given the account of how they proceeded “from the idea to the problem” and “from the idea to the mechanism”, the authors provide case studies showing how this mechanism allows working with learning difficulties to trigger simultaneous improvement in multiple developmental dimensions. The article reports on the experience of running special Summer Schools for children with learning difficulties, implementing the “Chess for General Development” Project, and assisting orphaned children with severe somatic conditions. A case study of a female college student displaying signs of the learned helplessness syndrome is presented. The authors infer that Vygotsky’s idea of a specific relationship between learning and development may be of fundamental theoretical and practical value, especially for working with children with special needs.

  4. Vygotsky's "Thought and Word"

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    Barrs, Myra

    2016-01-01

    The last chapter of Vygotsky's last book, "Thinking and Speech," is a compressed argument about the construction of consciousness through the internalisation of language. This article comments on Vygotsky's analysis of the "voyage into the interior" undertaken by oral speech as it is internalised and abbreviated into…

  5. Significance of Cultural-Historical Theory of Psychological Development of L.S. Vygotsky for the Development of Modern Models of Social Cognition and Psychotherapy

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    Kholmogorova A.B.,

    2016-12-01

    Full Text Available The article acknowledges the situation of methodical crisis in modern research of social cognition related to the domination of reductive approaches that ignore the uniqueness of human psyche. Heuristicity of concepts of cultural-historical theory of psychological development of L.S. Vygotsky, which serves to overcome the apparent inconsistencies is substantiated. Models of social cognition based on the principles of cultural-historical psychology are described, those being the model of social cognition within phylogenesis of M. Tomasello, and the model of social cognition within ontogenesis of C. Fernyhough. Current situation in the area of mental health is reviewed from the standpoint of cultural-historical psychology, its specifics reflected in the increased burden on reflexive functions, that is, skills lying within the sphere of social cognition is substantiated. Modern psychotherapeutic apparatus directed to compensate social cognition deficits due to various psychiatric disorders is reviewed. The assumption that adolescense is sensitive period for the development of higher forms of social cognition is made, and a summary of researches supporting this assertion is presented. Main contradictions of modern-day maturing are enunciated. To conclude the presented theoretical analysis, a comprehensive multiple-factor model of social cognition is presented based on concepts of cultural-historical theory of L.S. Vygotsky.

  6. Creativity in Gifted Education: Contributions from Vygotsky and Piaget

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    Stoltz, Tania; Piske, Fernanda Hellen Ribeiro; de Fátima Quintal de Freitas, Maria; D'Aroz, Marlene Schüssler; Machado, Járci Maria

    2015-01-01

    This research aims to highlight the importance of developing creativity in the school environment by promoting quality education to gifted students, with contributions from Vygotsky and Piaget. For Vygotsky creativity is inherent in the human condition, and it is the most important activity because it is the expression of consciousness, thought…

  7. Lev Semenovich Vygotsky (1896-1924): an introduction to the historico-cultural psychology and the development of the higher psychological processes.

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    Derouesné, Christian

    2017-09-01

    In the 1930's LS Vygotsky developed an original conception of the psychology and the development of the higher psychological processes, which stands up the current theories in Russia and the West. He layed the bases for the study of the higher mental processes and their relationship with the brain functioning, which will be later on developped by AR Luria. After a brief historical notice, this paper will specify the relationships between Vygoski and Marx's and Engels's philosophy, the Soviet power and the works of Freud and Piaget.

  8. Proximity sensor system development. CRADA final report

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    Haley, D.C.; Pigoski, T.M.

    1998-01-01

    Lockheed Martin Energy Research Corporation (LMERC) and Merritt Systems, Inc. (MSI) entered into a Cooperative Research and Development Agreement (CRADA) for the development and demonstration of a compact, modular proximity sensing system suitable for application to a wide class of manipulator systems operated in support of environmental restoration and waste management activities. In teleoperated modes, proximity sensing provides the manipulator operator continuous information regarding the proximity of the manipulator to objects in the workspace. In teleoperated and robotic modes, proximity sensing provides added safety through the implementation of active whole arm collision avoidance capabilities. Oak Ridge National Laboratory (ORNL), managed by LMERC for the United States Department of Energy (DOE), has developed an application specific integrated circuit (ASIC) design for the electronics required to support a modular whole arm proximity sensing system based on the use of capacitive sensors developed at Sandia National Laboratories. The use of ASIC technology greatly reduces the size of the electronics required to support the selected sensor types allowing deployment of many small sensor nodes over a large area of the manipulator surface to provide maximum sensor coverage. The ASIC design also provides a communication interface to support sensor commands from and sensor data transmission to a distributed processing system which allows modular implementation and operation of the sensor system. MSI is a commercial small business specializing in proximity sensing systems based upon infrared and acoustic sensors

  9. Proximity sensor system development. CRADA final report

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    Haley, D.C. [Oak Ridge National Lab., TN (United States); Pigoski, T.M. [Merrit Systems, Inc. (United States)

    1998-01-01

    Lockheed Martin Energy Research Corporation (LMERC) and Merritt Systems, Inc. (MSI) entered into a Cooperative Research and Development Agreement (CRADA) for the development and demonstration of a compact, modular proximity sensing system suitable for application to a wide class of manipulator systems operated in support of environmental restoration and waste management activities. In teleoperated modes, proximity sensing provides the manipulator operator continuous information regarding the proximity of the manipulator to objects in the workspace. In teleoperated and robotic modes, proximity sensing provides added safety through the implementation of active whole arm collision avoidance capabilities. Oak Ridge National Laboratory (ORNL), managed by LMERC for the United States Department of Energy (DOE), has developed an application specific integrated circuit (ASIC) design for the electronics required to support a modular whole arm proximity sensing system based on the use of capacitive sensors developed at Sandia National Laboratories. The use of ASIC technology greatly reduces the size of the electronics required to support the selected sensor types allowing deployment of many small sensor nodes over a large area of the manipulator surface to provide maximum sensor coverage. The ASIC design also provides a communication interface to support sensor commands from and sensor data transmission to a distributed processing system which allows modular implementation and operation of the sensor system. MSI is a commercial small business specializing in proximity sensing systems based upon infrared and acoustic sensors.

  10. The Role of L.S. Vygotsky's Ideas in the Development of Social Cognition Paradigm in Modern Psychology: A Review of Foreign Research and Discussion on Perspectives

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    A.B. Kholmogorova

    2015-10-01

    Full Text Available The author reflects on the reasons for the increased interest of modern foreign social cognition researchers in L.S. Vygotsky's cultural-historical theory in the light of the existing methodological contradictions and recent empirical data. The paper analyzes the main ideas and concepts of cultural-historical theory that were incorporated in research by Vygotsky's foreign followers, including such prominent experts in the field of social cognition as M. Tomasello and Ch. Fernyhough. It describes the conceptual apparatus and models of development of social cognition in phylo-, anthropo- and ontogenesis proposed by these researchers basing on the ideas of cultural-historical approach. The author especially stresses the importance of the idea of the dialogical nature of human thinking as the foundation for social cognition development in ontogenesis. Also reviewed are the mechanisms underlying the emergence of dialogical thinking from egocentric speech that are described in Ch. Fernyhough's model of social cognition development in ontogenesis. The paper concludes with an analysis of the concepts of cultural-historical theory and its current developments by Russian researchers that are of high heuristic potential for the future development of the paradigm of social cognition

  11. Vygotsky's Analysis of Children's Meaning Making Processes

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    Mahn, Holbrook

    2012-01-01

    Vygotsky's work is extensive and covers many aspects of the development of children's meaning-making processes in social and cultural contexts. However, his main focus is on the examination of the unification of speaking and thinking processes. His investigation centers on the analysis of the entity created by this unification--an internal…

  12. The predictive and discriminant validity of the zone of proximal development.

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    Meijer, J; Elshout, J J

    2001-03-01

    Dynamic measurement procedures are supposed to uncover the zone of proximal development and to increase predictive validity in comparison to conventional, static measurement procedures. Two alternative explanations for the discrepancies between static and dynamic measurements were investigated. The first focuses on Vygotsky's learning potential theory, the second considers the role of anxiety tendency during test taking. If test anxious tendencies are mitigated by dynamic testing procedures, in particular the availability of assistance, the concept of the zone of proximal development may be superfluous in explaining the differences between the outcomes of static and dynamic measurement. Participants were students from secondary education in the Netherlands. They were tested repeatedly in grade three as well as in grade four. Participants were between 14 and 17 years old; their average age was 15.4 years with a standard deviation of .52. Two types of mathematics tests were used in a longitudinal experiment. The first type of test consisted of open-ended items, which participants had to solve completely on their own. With the second type of test, assistance was available to participants during the test. The latter so-called learning test was conceived of as a dynamic testing procedure. Furthermore, a test anxiety questionnaire was administered repeatedly. Structural equation modelling was used to analyse the data. Apart from emotionality and worry, lack of self-confidence appears to be an important constituent of test anxiety. The learning test appears to contribute to the predictive validity of conventional tests and thus a part of Vygotsky's claims were substantiated. Moreover, the mere inclusion of a test anxiety factor into an explanatory model for the gathered data is not sufficient. Apart from test anxiety and mathematical ability it is necessary to assume a factor which may be construed as mathematics learning potential. The results indicate that the observed

  13. VIGOTSKI, DESARROLLO INFANTIL Y APORTES PARA EL AULA COSTARRICENSE VYGOTSKY, (CHILD DEVELOPMENT AND CONTRIBUTIONS TO THE COSTARRICAN CLASSROOM

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    Antoni Maurizia D’

    2009-11-01

    Full Text Available Resumen:En el presente ensayo es producto de un curso sobre Vigotski con la profesora Wanda Rodríguez Arocho en el marco del Congreso sobre Vigotski y Freire de 2007, donde se buscó trabajar dos conceptos vigotskianos, zona de desarrollo próximo y situación social de desarrollo, sirviéndome de mi experiencia personal, de un lado para denunciar y de otro para proponer. Uno de estos ámbitos de experiencia nace del Módulo de Psicología Educativa II, de la Escuela de Psicología de la Universidad de Costa Rica, donde nos enfrentamos al desconcierto de los estudiantes y las estudiantes del curso, quienes tienen que realizar prácticas en Escuelas de Atención Prioritaria, del Gran Área Metropolitana, y cuyo uso de instrumentos de medición tradicionales implican el riesgo de etiquetar y lastimar a los niños y las niñas que participan en la actividad. En ese sentido, proponemos que la incorporación de los conceptos vigotskianos citados llevan a una práctica de aula más favorecedora, justa y equitativa del desarrollo cognitivo en estudiantes costarricenses. Por el momento, hemos obtenido el alcance de poner en el debate la inquietud teórica para integrarla a los planes de estudio y al trabajo concreto de aula.Abstract:This essay is a product of a class taken with the professor Wanda Rodríguez Arocho during the 2007 Vigotski and Freire Congres. Based on my personal experience, I worked with two vigotskian concepts: Zone of Proximal Developement y Social Situations of Development, to denunce first and to propose later. Part of my experience takes place in the II Educative Psichology Module, in the University of Costa Rica's School of Psichology, where I have faced the student's astonishment when using traditional measuring instruments in Primary Schools, instruments that imply to label and to hurt the children involved in the activity. My proposition is the incorporation of the cited vigotskian concepts leads to a better cognitive

  14. Proximity Operations and Docking Sensor Development

    Science.gov (United States)

    Howard, Richard T.; Bryan, Thomas C.; Brewster, Linda L.; Lee, James E.

    2009-01-01

    The Next Generation Advanced Video Guidance Sensor (NGAVGS) has been under development for the last three years as a long-range proximity operations and docking sensor for use in an Automated Rendezvous and Docking (AR&D) system. The first autonomous rendezvous and docking in the history of the U.S. Space Program was successfully accomplished by Orbital Express, using the Advanced Video Guidance Sensor (AVGS) as the primary docking sensor. That flight proved that the United States now has a mature and flight proven sensor technology for supporting Crew Exploration Vehicles (CEV) and Commercial Orbital Transport Systems (COTS) Automated Rendezvous and Docking (AR&D). NASA video sensors have worked well in the past: the AVGS used on the Demonstration of Autonomous Rendezvous Technology (DART) mission operated successfully in spot mode out to 2 km, and the first generation rendezvous and docking sensor, the Video Guidance Sensor (VGS), was developed and successfully flown on Space Shuttle flights in 1997 and 1998. 12 Parts obsolescence issues prevent the construction of more AVGS units, and the next generation sensor was updated to allow it to support the CEV and COTS programs. The flight proven AR&D sensor has been redesigned to update parts and add additional capabilities for CEV and COTS with the development of the Next Generation AVGS at the Marshall Space Flight Center. The obsolete imager and processor are being replaced with new radiation tolerant parts. In addition, new capabilities include greater sensor range, auto ranging capability, and real-time video output. This paper presents some sensor hardware trades, use of highly integrated laser components, and addresses the needs of future vehicles that may rendezvous and dock with the International Space Station (ISS) and other Constellation vehicles. It also discusses approaches for upgrading AVGS to address parts obsolescence, and concepts for minimizing the sensor footprint, weight, and power requirements

  15. "The Mozart of Psychology": "Mind in Society" by L. S. Vygotsky: Implications for Improving Literacy.

    Science.gov (United States)

    Friedman, Sheila

    L. S. Vygotsky's book "Mind in Society" was published more than 50 years ago in Russia, but it is now being recognized as relevant to contemporary research in child development because of the areas of investigation that he suggested. Vygotsky views children as active participants in their own learning and suggests that researchers…

  16. A Biographic Comparison Tracing the Origin of Their Ideas of Jean Piaget and Lev Vygotsky.

    Science.gov (United States)

    Pass, Susan

    This paper compares the early life, background, and education of Jean Piaget and Lev Vygotsky. It makes the case that an adaptation of the curve developed by C. Quigley can be used to trace the motivations of both Piaget and Vygotsky in creating their respective theories. The analysis also reveals the adversity that each man faced. Although they…

  17. To Moscow with love: partial reconstruction of Vygotsky's trip to London.

    Science.gov (United States)

    van der Veer, René; Zavershneva, Ekaterina

    2011-12-01

    The Russian psychologist Lev Vygotsky (1896-1934) left the Soviet Union only once to attend a conference on the education of the deaf in London. So far almost nothing was known about this trip, which took place in a period when Vygotsky was still completely unknown as a psychologist, both inside his own country and abroad. Making use of a newly discovered notebook, it proved possible to partially reconstruct Vygotsky's journey and stay in London. Vygotsky's very personal remarks show him to have been a very sensitive and spirited man, who was prey to strong emotions during the conference and afterwards. Rather surprisingly, Vygotsky's own paper about the education of the deaf was never presented during the conference and the stay in London appears to have had a limited value for his own scientific development.

  18. Proximal Focal Femoral Deficiency in Ibadan a Developing ...

    African Journals Online (AJOL)

    The cultural aversion to amputation in our environment makes it difficult to employ that option of treatment. Proximal focal femoral deficiency in Ibadan a developing country's perspective and a review of the literature. Keywords: Proximal focal femoral deficiency , congenital malformations , limb malformations , lower limb ...

  19. Application of the principles of Vygotsky's sociocultural theory of ...

    African Journals Online (AJOL)

    Sociocultural theory by Vygotsky (1896-1934) is a theory that has become popular in educational practice in recent years. It is especially important in the instruction of children in the preschool level as it is most suitable for their development and learning, which is more of social interaction. This paper discussed the ...

  20. Tolstoy, Vygotsky, and the Making of Meaning.

    Science.gov (United States)

    Berthoff, Ann E.

    1978-01-01

    Leo Tolstoy and Lev Vygotsky, like Sylvia Ashton-Warner, Maria Montessori, and Paulo Freire, base their educational philosophies on the heuristic power of language, the form-finding, and form-creating powers of the human mind. (DD)

  1. Pupils, Tools and the Zone of Proximal Development

    Science.gov (United States)

    Abtahi, Yasmine

    2018-01-01

    In this article, I use the Vygotskian concept of the Zone of Proximal Development (ZPD) to examine the learning experience of two grade seven pupils as they attempted to solve an addition of fractions problem using fraction strips. The aim is to highlight how tools can facilitate the enactment of a ZPD, within which the tool provides the guidance.…

  2. [Vygotsky's Social-Historic Constructivism and nursing].

    Science.gov (United States)

    Thofehrn, Maira Buss; Leopardi, Maria Tereza

    2006-01-01

    The aim of this paper is to reflect, in the theoretical scope, about the Vygotsky's socio-historical constructivism and the contributions from this Russian researcher to build the nursing knowledge. The Vygotskian approach has as its philosophical, epistemological and methodological purposes, the principles of the historical materialism, it emphasizes the social and cultural context in the working process, also in the use of instruments and in the dialectical interaction between human beings and environment. We understand that the ideas preconized by Vygotsky can represent an alternative method to the practical and theoretical studies, specially, as the subjective dimension of the working process near by the nursing staff.

  3. Integrating Vygotsky's theory of relational ontology into early childhood science education

    Science.gov (United States)

    Kirch, Susan A.

    2014-03-01

    In Science Education during Early Childhood: A Cultural- Historical Perspective, Wolff-Michael Roth, Maria Inês Mafra Goulart and Katerina Plakitsi explore the practical application of Vygotsky's relational ontological theory of human development to early childhood science teaching and teacher development. In this review, I interrogate how Roth et al. conceptualize "emergent curriculum" within the Eurocentric cultural-historical traditions of early childhood education that evolved primarily from the works of Vygotsky and Piaget and compare it to the conceptualizations from other prominent early childhood researchers and curriculum developers. I examine the implications of the authors' interpretation of emergence for early childhood science education and teacher preparation.

  4. Mapping subsurface in proximity to newly-developed sinkhole along roadway.

    Science.gov (United States)

    2013-02-01

    MS&T acquired electrical resistivity tomography profiles in immediate proximity to a newly-developed sinkhole in Nixa Missouri : The sinkhole has closed a well-traveled municipal roadway and threatens proximal infrastructure. The intent of this inves...

  5. Positive psychology and ideas of cultural-historical school of L.S. Vygotsky

    Directory of Open Access Journals (Sweden)

    Vasilev V.K.,

    2017-08-01

    Full Text Available In the article was carried out a comparative analysis between two distinctive psychology schools: the cultural-historical psychology of L.V. Vygotsky and the positive psychological school. Distinct are a number of significant similarities between their basic ideas that are valuable both for the development of human knowledge and for public practice. The authors have outlined and systematized the leading personal and intellectual qualities of the famous psychologists who have created the most promising theories in the psychological science. The category is highlighted as well as a small group of visionary psychologists who have identified the most important problems of man and psychology and have offered the best quality solutions to these problems. These are W. James, S. Freud, L. Vygotsky, E. Eriksson and A. Maslow; We’ve noticed that Vygotsky alone meets all the criteria, as if the concept of insightful psychologists was modeled over his creative work and his personality.

  6. Understanding partnership practice in primary health as pedagogic work: what can Vygotsky's theory of learning offer?

    Science.gov (United States)

    Hopwood, Nick

    2015-01-01

    Primary health policy in Australia has followed international trends in promoting models of care based on partnership between professionals and health service users. This reform agenda has significant practice implications, and has been widely adopted in areas of primary health that involve supporting families with children. Existing research shows that achieving partnership in practice is associated with three specific challenges: uncertainty regarding the role of professional expertise, tension between immediate needs and longer-term capacity development in families, and the need for challenge while maintaining relationships based on trust. Recently, pedagogic or learning-focussed elements of partnership practice have been identified, but there have been no systematic attempts to link theories of learning with the practices and challenges of primary health-care professionals working with families in a pedagogic role. This paper explores key concepts of Vygotsky's theory of learning (including mediation, the zone of proximal development, internalisation, and double stimulation), showing how pedagogic concepts can provide a bridge between the policy rhetoric of partnership and primary health practice. The use of this theory to address the three key challenges is explicitly discussed.

  7. Changes in proximate composition and oil characteristics during flaxseed development

    Directory of Open Access Journals (Sweden)

    Herchi, W.

    2014-06-01

    Full Text Available Atmospheric Pressure Photoionization-Mass Spectrometry (APPI-MS and High Performance Liquid Chromatography (HPLC are the two analytical methods that were used to characterize Triacylglycerols (TAGs during flaxseed development. The HPLC method of the oils showed the presence of 15 TAG species. In contrast to the HPLC chromatograms, the APPI-MS showed 17 peaks of TAG. APPI-MS is more rapid than the HPLC method (11 min. The iodine value of the oils showed a gradual increase, while the oil stability continuously decreased. Proximate composition during flaxseed development revealed that flaxseed is potentially a good source of dietary energy and protein. At full maturity, flaxseed contained 37% oil and 24% protein on a dry-weight basis; albumin was the major storage protein (53% of total storage proteins followed by globulin (33% and glutelin fractions (11%. Prolamins had the lowest percentage with 3%. α-amylase activity was higher in the mature seeds than the young ones.Fotoionización a presión atmosférica-Espectrometría de masas (APPI-MS y cromatografía líquida de alta resolución (HPLC son dos métodos de análisis que se utilizaron para caracterizar triglicéridos (TAGs durante el desarrollo de semillas de linaza. El método HPLC mostró la presencia de 15 especies de TAG, en contraste, los cromatogramas de APPI-MS mostraron 17 picos de TAG siendo el método APPI-MS más rápido que el de HPLC (11 min. El índice de yodo de los aceites mostró un aumento gradual, mientras que la estabilidad disminuyó continuamente. El estudio de la composición proximal de la linaza durante su desarrollo, mostró que esta semilla es una fuente potencialmente buena de energía y de proteína para la dieta. Al final de la maduración, la linaza contenía 37 % de aceite y 24 % de proteína sobre peso seco; albúmina fue la principal proteína de almacenamiento (53% sobre el total de las proteínas de almacenamiento seguido de la globulina (33 % y glutelina

  8. Operationalizing Levels of Academic Mastery Based on Vygotsky's Theory: The Study of Mathematical Knowledge

    Science.gov (United States)

    Nezhnov, Peter; Kardanova, Elena; Vasilyeva, Marina; Ludlow, Larry

    2015-01-01

    The present study tested the possibility of operationalizing levels of knowledge acquisition based on Vygotsky's theory of cognitive growth. An assessment tool (SAM-Math) was developed to capture a hypothesized hierarchical structure of mathematical knowledge consisting of procedural, conceptual, and functional levels. In Study 1, SAM-Math was…

  9. Durkheim and Vygotsky's Theories of Knowledge and Their Implications for a Critical Educational Theory

    Science.gov (United States)

    Young, Michael

    2007-01-01

    This paper is part of the ongoing work of the author and others in developing a social realist theory of knowledge for educational studies. It contrasts Durkheim and Vygotsky's theories and why both are important for educational theory. It begins by emphasizing the similarities between them; that knowledge has to be understood in terms of its…

  10. Lev Seminovich Vygotski: Biography of a genius

    OpenAIRE

    Borovica, Tamara P.

    2012-01-01

    In this paper, from the point of interpretative paradigm, we are analysing the biography of a significant scientists of the 20th century Lev Semionovich Vygotsky. Vygotski’s life story is equally significant as his scientific research, so as in his cultural-historical theory denoting the most significant social and historical moments in the period he lived in. Apart from the crisis of psychology foundation, which in the end of the 19th century and at the beginning of the 20th century, shakes ...

  11. Vygotsky's Sociocultural Theory in the Context of Globalization

    Science.gov (United States)

    Marginson, Simon; Dang, Thi Kim Anh

    2017-01-01

    The article reviews the social-educational theorization of the early Soviet psychologist L. S. Vygotsky (1896-1934) in the light of the impact of communicative globalization in educational practice. Vygotsky proposed four "genetic domains" for investigating higher cognitive processes: the phylogenetic (humans undergoing natural…

  12. The Unity of Intellect and Will: Vygotsky and Spinoza

    Science.gov (United States)

    Derry, Jan

    2004-01-01

    Jerome Bruner points out in his prologue to the first volume of the English translation of The Collected Works that Vygotsky flirts with the idea that language creates free will. This article attempts to consider the influence of the Dutch seventeenth-century philosopher Spinoza on Vygotsky. An account of Spinoza's anti-Cartesian conception of…

  13. Not by bread alone: Lev Vygotsky's Jewish writings.

    Science.gov (United States)

    Zavershneva, Ekaterina; van der Veer, René

    2018-02-01

    On the basis of both published and unpublished manuscripts written from 1914 to 1917, this article gives an overview of Lev Vygotsky's early ideas. It turns out that Vygotsky was very much involved in issues of Jewish culture and politics. Rather surprisingly, the young Vygotsky rejected all contemporary ideas to save the Jewish people from discrimination and persecution by creating an autonomous state in Palestine or elsewhere. Instead, until well into 1917, Vygotsky proposed the rather traditional option of strengthening the spiritual roots of the Jews by returning to the religious writings. Socialism was rejected, because it merely envisioned the compulsory redistribution of material goods and 'man lives not by bread alone'. It was only after the October Revolution that Vygotsky switched from arguments in favour of the religious faith in the Kingship of God to the communist belief in a Radiant Future.

  14. Developing survey metrics for analysing cross-border proximity

    DEFF Research Database (Denmark)

    Makkonen, Teemu; Williams, Allan

    2018-01-01

    attempts to operationalize the varying types of proximity – in relation to CBIC – in the form of a questionnaire tested through pilot studies of two CBRs, at the Finnish–Swedish and Danish–German border, and for two contrasting service industries, namely knowledge-intensive business services and tourism...

  15. Developing the Ideas of the Scientific School of L.S. Vygotsky: Scientific Publications of the Journal “Cultural-Historical Psychology” (2005—2016

    Directory of Open Access Journals (Sweden)

    Shvedovskaya A.A.,

    2016-12-01

    Full Text Available The article presents the analysis of the development of the ideas of L.S. Vygotsky’s school using the example of the publications in the international scientific journal “Cultural-Historical Psychology” (for the period 2005 through 2016. Over the period from 2005 to the end of 2016, 595 articles of 524 authors from 32 countries have been published in the journal “Cultural-Historical Psychology.” The study of the subjects of the articles published in the journal was held within the framework of the following criteria: scientometric publication indicators; group of authors; themes of the publications; relevance of the articles for their readers. The research uses the following sources: Russian Science Citation Index (RSCI; repository data of the psychological editions of PsyJournals.ru; report data on the activities of the journal “Cultural-Historical Psychology.” The citation frequency of the journal’s publications peaks in 2007, 2009 and 2006. Empirical findings comprise major part of the publications. The most developed areas are the studies of speech and thinking, personality, and communication.

  16. Development of procedures for programmable proximity aperture lithography

    Energy Technology Data Exchange (ETDEWEB)

    Whitlow, H.J., E-mail: harry.whitlow@he-arc.ch [Institut des Microtechnologies Appliquées Arc, Haute Ecole Arc Ingénierie, Eplatures-Grise 17, CH-2300 La Chaux-de-Fonds (Switzerland); Department of Physics, University of Jyväskylä, P.O. Box 35 (YFL), FI-40014 Jyväskylä (Finland); Gorelick, S. [VTT Technical Research Centre of Finland, P.O. Box 1000, Tietotie 3, Espoo, FI-02044 VTT (Finland); Puttaraksa, N. [Department of Physics, University of Jyväskylä, P.O. Box 35 (YFL), FI-40014 Jyväskylä (Finland); Plasma and Beam Physics Research Facility, Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai 50200 (Thailand); Napari, M.; Hokkanen, M.J.; Norarat, R. [Department of Physics, University of Jyväskylä, P.O. Box 35 (YFL), FI-40014 Jyväskylä (Finland)

    2013-07-01

    Programmable proximity aperture lithography (PPAL) with MeV ions has been used in Jyväskylä and Chiang Mai universities for a number of years. Here we describe a number of innovations and procedures that have been incorporated into the LabView-based software. The basic operation involves the coordination of the beam blanker and five motor-actuated translators with high accuracy, close to the minimum step size with proper anti-collision algorithms. By using special approaches, such writing calibration patterns, linearisation of position and careful backlash correction the absolute accuracy of the aperture size and position, can be improved beyond the standard afforded by the repeatability of the translator end-point switches. Another area of consideration has been the fluence control procedures. These involve control of the uniformity of the beam where different approaches for fluence measurement such as simultaneous aperture current and the ion current passing through the aperture using a Faraday cup are used. Microfluidic patterns may contain many elements that make-up mixing sections, reaction chambers, separation columns and fluid reservoirs. To facilitate conception and planning we have implemented a .svg file interpreter, that allows the use of scalable vector graphics files produced by standard drawing software for generation of patterns made up of rectangular elements.

  17. Using the Transformative Power of Play to Educate Hearts and Minds: From Vygotsky to Vivian Paley and Beyond

    Science.gov (United States)

    Nicolopoulou, Ageliki; Barbosa De Sa, Aline; Ilgaz, Hande; Brockmeyer, Carolyn

    2010-01-01

    This article argues that Vygotsky's analysis of children's play and of the ways it can serve as a powerful matrix for learning and development has two important implications that are not always fully appreciated. First, children's social pretend play can promote development both in the domains of cognition and language "and" in…

  18. Economic development, place-based development strategies and the conceptualization of proximity in European urban regions

    NARCIS (Netherlands)

    Dogaru, Dora; van Oort, Frank; Thissen, M.

    2014-01-01

    The discussion on proximity has evolved in various theoretical, conceptual and empirical directions since the seminal contributions by Torre and Rallet (2005) and Boschma (2005). One of the main arguments for conceptualizing proximities other than physical proximities is embedded in the ever-growing

  19. The zone of proximal development in the learning of mathematics

    Directory of Open Access Journals (Sweden)

    Sibawu Siyepu

    2013-01-01

    Full Text Available South Africa has a huge shortage of skilled workers in various fields such as engineering, applied sciences, accountancy, architecture, medicine and law. Mathematics is a requirement for entry in these careers to enable learners to grasp the content of various subjects in these disciplines. Despite that, in South Africa, learners' performance in mathematics is shocking. This article highlights the high failure rate of mathematics in a South African context. It suggests possible causes of learners' poor performance based on the literature. The article brings a socio-cultural theory of learning focusing on the zone ofproximal development as a possible solution in the development of instructional practices. It makes recommendations on what should be done to tackle anticipated problems as suggested in the discussion.

  20. Application of proximal surrogate indicators for safety evaluation: A review of recent developments and research needs

    Directory of Open Access Journals (Sweden)

    S.M. Sohel Mahmud

    2017-12-01

    Full Text Available Although there have been a number of recent reviews on the use of traffic conflict techniques (TCTs, none have focused on the use of proximal surrogate indicators. This paper comprehensively reviews the development and application of proximal surrogate safety indicators to address this gap. There is a particular focus on more recent advancements in the application of such indicators. For each of the main indicators reviewed, the paper provides a synthesis of the main guiding principles, as well as the most prominent features, including critical or threshold values used in the past. In addition, the main advantages and disadvantages of the reviewed indicators are highlighted. Finally, a number of research gaps are identified together with recommendations for potentially useful avenues of future research. Keywords: Safety evaluation, Traffic conflict, Surrogate, Proximal, Indicators

  1. Vygotsky: uma base teórica para a proposta do ensino por meio de ciclos

    Directory of Open Access Journals (Sweden)

    Tarcísio Renan Peireira Sousa Resende

    2017-10-01

    educational community. It should be noted that there is some resistance on the part of teachers, as well as a distorted view of the substance of the proposal. In this sense, this study aimed to analyze the conceptions and the bases of the cycled school, relating it to the socio-interactionist theory of Vygotsky. This is a descriptive-exploratory research, based on bibliographical-documentary research. Basal authors Vygotsky (2015, 2013, 1998, Rego (2009, Mainardes (2009 Mato Grosso (2010 and Brazil (1996 were used as baseline authors. Teaching through cycles implies that the school considers the individual as a social-historical being, taking into account the environment in which it is inserted, and thus develop pedagogical practices in the school environment that expand and develop the skills that still need to be appropriate and understood from the social interaction of each subject. It is concluded that the proposal of schools organized in cycles is based on the socio-interactionist theory of Vygotsky, however, some factors are limiting, among them the lack of sufficient training of teachers, to execute the proposal. It is believed that if this approach is well worked out, it will be possible to have a more inclusive school that is close to the community in which it is inserted, that promotes closer approximation of the student with the scientific knowledge, as well as the possibility of advancing in the sociohistorical process of humanization, creating possibilities for it to be a subject capable of contributing to a social transformation. Keywords: Sociointeractionism. Vygotsky. Organization of the school in cycles.  Vygotsky: una base teórica para una propuesta de enseñanza por medio de los ciclos RESUMEN El modelo de escuela organizada por ciclo ha sido escenario de discusiones en la comunidad educativa brasileña. Se percibió que existe cierta resistencia por parte docente, así como una visión distorsionada de la esencia de dicha propuesta. En ese sentido, este

  2. 'Re-zoning' proximal development in a parallel e-learning course ...

    African Journals Online (AJOL)

    'Re-zoning' proximal development in a parallel e-learning course. ... Journal Home > Vol 22, No 4 (2002) >. Log in or Register to get access to full text downloads. ... This twinning course was introduced to expand learning opportunities in what we ... face-to-face curriculum with less scheduled teaching time than previously.

  3. Mind and Meaning: Piaget and Vygotsky on Causal Explanation.

    Science.gov (United States)

    Beilin, Harry

    1996-01-01

    Piaget's theory has been characterized as descriptive and not explanatory, not qualifying as causal explanation. Piaget was consistent in showing how his theory was both explanatory and causal. Vygotsky also endorsed causal-genetic explanation but, on the basis of knowledge of only Piaget's earliest works, he claimed that Piaget's theory was not…

  4. Wundt, Vygotsky and Bandura: a cultural-historical science of consciousness in three acts.

    Science.gov (United States)

    Ferrari, Michel; Robinson, David K; Yasnitsky, Anton

    2010-01-01

    This article looks at three historical efforts to coordinate the scientific study of biological and cultural aspects of human consciousness into a single comprehensive theory of human development that includes the evolution of the human body, cultural evolution and personal development: specifically, the research programs of Wilhelm Wundt, Lev Vygotsky and Albert Bandura. The lack of historical relations between these similar efforts is striking, and suggests that the effort to promote cultural and personal sources of consciousness arises as a natural foil to an overemphasis on the biological basis of consciousness, sometimes associated with biological determinism.

  5. Design and development of a Space Station proximity operations research and development mockup

    Science.gov (United States)

    Haines, Richard F.

    1986-01-01

    Proximity operations (Prox-Ops) on-orbit refers to all activities taking place within one km of the Space Station. Designing a Prox-Ops control station calls for a comprehensive systems approach which takes into account structural constraints, orbital dynamics including approach/departure flight paths, myriad human factors and other topics. This paper describes a reconfigurable full-scale mock-up of a Prox-Ops station constructed at Ames incorporating an array of windows (with dynamic star field, target vehicle(s), and head-up symbology), head-down perspective display of manned and unmanned vehicles, voice- actuated 'electronic checklist', computer-generated voice system, expert system (to help diagnose subsystem malfunctions), and other displays and controls. The facility is used for demonstrations of selected Prox-Ops approach scenarios, human factors research (work-load assessment, determining external vision envelope requirements, head-down and head-up symbology design, voice synthesis and recognition research, etc.) and development of engineering design guidelines for future module interiors.

  6. DEVELOPMENT OF A WEB-BASED PROXIMITY BASED MEDIA SHARING APPLICATION

    OpenAIRE

    Erol Ozan

    2016-01-01

    This article reports the development of Vissou, which is a location based web application that enables media recording and sharing among users who are in close proximity to each other. The application facilitates the automated hand-over of the recorded media files from one user to another. There are many social networking applications and web sites that provide digital media sharing and editing functionalities. What differentiates Vissou from other similar applications is the functions and us...

  7. The normal development of proximal humeral epiphyseal ossification center in the first 2 years of life

    International Nuclear Information System (INIS)

    Kim, Seung Cheol

    1998-01-01

    The purpose of this study is to ascertain the normal maturation of proximal epiphyseal ossification centers by monthly age during the first years of life. The distribution of age was 0 to 24 months. Six hundred and seventy-five infants were male and 436 were female; their ages were measured in months, and there was no evidence of developmental problems. Proximal humeral epiphyseal ossification centers were evaluated from chest radiographs ; if not visualized, they were graded as 0, and otherwise, as follows : grade 1 : visualized with poor margin or a diameter of less than 1/4 of metaphyseal width; grade 2: visualized with good margin or a diameter of more than 1/4 of metaphyseal width; in grade 3 and 4, two ossification centers were visualized. Grade 3 indicated that one ossification center had the morphology of grade 2. Grade 5 indicated that two ossification centers were fused. We then assessed the relationship between the development of an ossification center and monthly age. A proximal humeral epiphyseal ossification center shows regular maturational features according to monthly age. 6 refs., 2 tabs., 5 figs

  8. Papel do professor: de Erasmo de Rotterdam a Vygotsky - Teacher's role: of Rotterdam Erasmo the Vygotsky

    Directory of Open Access Journals (Sweden)

    Ada Augusta Celestino Bezerra

    2016-09-01

    Full Text Available ResumoO artigo analisa o circuito de ideias pedagógicas sobre a função e preparação do professor ao longo da história, sob o recorte do século XVI ao século XX, a partir das contribuições de doze teóricos/filósofos da educação, do Manifesto dos Pioneiros da Educação Nova no Brasil (1932 e do Manifesto dos Educadores. O diálogo com os teóricos estabeleceu-se cronologicamente, considerando os contextos em que as obras foram publicadas e/ou difundidas, com suas implicações no papel do professor. A metodologia adotada foi a revisão bibliográfica que permitiu o retorno aos clássicos que evocaram para si o pensar sobre o processo educativo e suas relações com a sociedade. O estudo partiu de Erasmo de Rotterdam (séc. XVI até alcançar o pensamento de Vygotsky (século XX. Nas considerações finais destaca afinidades e avanços em torno da função docente, reconhecendo que está concretamente colocado à consideração e criatividade dos educadores na contemporaneidade o desafio da construção de uma educação que, mesmo situada no contexto das determinações capitalistas, forme o aluno para o exercício pleno da cidadania a partir da apropriação da cultura produzida social e historicamente pela humanidade e da radicalização do discurso neoliberal dos governos. Para esse fim aponta como componentes da formação do professor: o conhecimento científico-cultural, o conhecimento pedagógico e didático, ao lado do conhecimento profissional docente, requeridos para a inscrição na profissão de professor.    

  9. Raptor nest-site use in relation to the proximity of coalbed methane development

    Science.gov (United States)

    Carlile, J.D.; Sanders, Lindsey E.; Chalfoun, Anna D.; Gerow, K.G.

    2018-01-01

    Raptor nest–site use in relation to the proximity of coalbed–methane development. Energy development such as coalbed–methane (CBM) extraction is a major land use with largely unknown consequences for many animal species. Some raptor species may be especially vulnerable to habitat changes due to energy development given their ecological requirements and population trajectories. Using 12,977 observations of 3,074 nests of 12 raptor species across nine years (2003–2011) in the Powder River Basin, Wyoming, USA, we evaluated relationships between raptor nest–site use and CBM development. Our objectives were to determine temporal trends in nest–use rates, and whether nest–site use was related to the proximity of CBM development. Across the study area, nest–use rates varied across species and years in a non–linear fashion. We developed a novel randomization test to assess differences in use between nests at developed and undeveloped sites, while controlling for annual variation in nest–site use. Red–tailed hawks (Buteo jamaicensis), burrowing owls (Athene cunicularia), and long–eared owls (Asio otus) used nests in undeveloped areas more than nests in developed areas (i.e. nests near CBM development). Differences between development groups were equivocal for the remaining nine species; however, we caution that we likely had lower statistical power to detect differences for rarer species. Our findings suggest potential avoidance of nesting in areas near CBM development by some species and reveal that CBM effects may be fairly consistent across distances between 400–2,415 m from wells. Future work should consider habitat preferences and fitness outcomes, and control for other key factors such as local prey availability, raptor densities, and weather.

  10. Zone of Proximal Development (ZPD) as an Emergent System: A Dynamic Systems Theory Perspective.

    Science.gov (United States)

    Karimi-Aghdam, Saeed

    2017-03-01

    This paper sets out to present a novel construal of one of the notions of Vygotskian cultural-historical theory viz., zone of proximal development (ZPD) drawing upon dynamic systems theory. The principal thesis maintains that ZDP is an emergent and dynamic system which is engendered by a dialectical concatenation of psychogenesic and sociogenesic facets of human development over time. It is reasoned that Vygotskian cultural-historical theory of human development, by invoking dialectical logic, has transcended Cartesian substance dualism and in turn has proffered a monistic and process-anchored ontology for emerging becoming of human consciousness. Likewise, it is contended that dynamic systems theory, having assumed fluent flux of reality with a capital R as its ontological axiom, entails a consilience of cognitive and contextual conceptual schemes to describe, explain, and optimize human development. The paper concludes by drawing some interpretive conclusions in regard to ZPD from dynamic systems theory perspective.

  11. Development of a hardware-in-the-loop testbed to demonstrate multiple spacecraft operations in proximity

    Science.gov (United States)

    Eun, Youngho; Park, Sang-Young; Kim, Geuk-Nam

    2018-06-01

    This paper presents a new state-of-the-art ground-based hardware-in-the-loop test facility, which was developed to verify and demonstrate autonomous guidance, navigation, and control algorithms for space proximity operations and formation flying maneuvers. The test facility consists of two complete spaceflight simulators, an aluminum-based operational arena, and a set of infrared motion tracking cameras; thus, the testbed is capable of representing space activities under circumstances prevailing on the ground. The spaceflight simulators have a maximum of five-degree-of-freedom in a quasi-momentum-free environment, which is produced by a set of linear/hemispherical air-bearings and a horizontally leveled operational arena. The tracking system measures the real-time three-dimensional position and attitude to provide state variables to the agents. The design of the testbed is illustrated in detail for every element throughout the paper. The practical hardware characteristics of the active/passive measurement units and internal actuators are identified in detail from various perspectives. These experimental results support the successful development of the entire facility and enable us to implement and verify the spacecraft proximity operation strategy in the near future.

  12. CONTRIBUTIONS OF HEBB AND VYGOTSKY TO AN INTEGRATED SCIENCE OF MIND

    Science.gov (United States)

    Ghassemzadeh, Habibollah; Posner, Michael I.; Rothbart, Mary K.

    2013-01-01

    Hebb and Vygotsky are two of the most influential figures of psychology in the first half of the 20th century. They represent cultural and biological approaches to explaining human development, and thus a number of their ideas remain relevant to current psychology and cognitive neuroscience. In this paper we examine similarities and differences between these two important figures, exploring possibilities for a theoretical synthesis between their two literatures, which have had little contact each other. To pursue these goals the following topics are discussed: 1) Hebb and Vygotsky’s lives and training; 2) their innovations in theory building relating to an “objective psychology” and objective science of mind, 3) their developmental approach, 4) their treatment of mediation and neuropsychology and 5) their current relevance and possible integration of their views. We argue that considering the two together improves prospects for a more complete and integrated approach to mind and brain in society. PMID:23679195

  13. Concept and development of an orthotropic FE model of the proximal femur.

    Science.gov (United States)

    Wirtz, Dieter Christian; Pandorf, Thomas; Portheine, Frank; Radermacher, Klaus; Schiffers, Norbert; Prescher, Andreas; Weichert, Dieter; Niethard, Fritz Uwe

    2003-02-01

    In contrast to many isotropic finite-element (FE) models of the femur in literature, it was the object of our study to develop an orthotropic FE "model femur" to realistically simulate three-dimensional bone remodelling. The three-dimensional geometry of the proximal femur was reconstructed by CT scans of a pair of cadaveric femurs at equal distances of 2mm. These three-dimensional CT models were implemented into an FE simulation tool. Well-known "density-determined" bony material properties (Young's modulus; Poisson's ratio; ultimate strength in pressure, tension and torsion; shear modulus) were assigned to each FE of the same "CT-density-characterized" volumetric group. In order to fix the principal directions of stiffness in FE areas with the same "density characterization", the cadaveric femurs were cut in 2mm slices in frontal (left femur) and sagittal plane (right femur). Each femoral slice was scanned into a computer-based image processing system. On these images, the principal directions of stiffness of cancellous and cortical bone were determined manually using the orientation of the trabecular structures and the Haversian system. Finally, these geometric data were matched with the "CT-density characterized" three-dimensional femur model. In addition, the time and density-dependent adaptive behaviour of bone remodelling was taken into account by implementation of Carter's criterion. In the constructed "model femur", each FE is characterized by the principal directions of the stiffness and the "CT-density-determined" material properties of cortical and cancellous bone. Thus, on the basis of anatomic data a three-dimensional FE simulation reference model of the proximal femur was realized considering orthotropic conditions of bone behaviour. With the orthotropic "model femur", the fundamental basis has been formed to realize realistic simulations of the dynamical processes of bone remodelling under different loading conditions or operative procedures

  14. Emotion and Exclusion: Key Ideas from Vygotsky to Review our Role in a School with a Cultural Diversity Setting

    Directory of Open Access Journals (Sweden)

    Enrique Riquelme MELLA

    Full Text Available ABSTRACT: Research demonstrates that minorities' children diagnosed with Emotional and Behavioural Disorders is overrepresented, being the ethnic minorities the most affected. The diagnostics have resulted in racism and discrimination. This article reflects upon the necessity to develop more integrated and dynamic models of inclusion for the schools. Based on Vygotsky´s ideas, a reflexion is done regarding the emotional education in schools, specifically about the need to include -in the teacher formation- the main role of the culture emotional rules in the dynamic of exclusion/inclusion of minorities. The article concludes with proposals to be considered for a culturally sensible vision on inclusion.

  15. Proximate effects of temperature versus evolved intrinsic constraints for embryonic development times among temperate and tropical songbirds

    Science.gov (United States)

    Ton, Riccardo; Martin, Thomas E.

    2017-01-01

    The relative importance of intrinsic constraints imposed by evolved physiological trade-offs versus the proximate effects of temperature for interspecific variation in embryonic development time remains unclear. Understanding this distinction is important because slow development due to evolved trade-offs can yield phenotypic benefits, whereas slow development from low temperature can yield costs. We experimentally increased embryonic temperature in free-living tropical and north temperate songbird species to test these alternatives. Warmer temperatures consistently shortened development time without costs to embryo mass or metabolism. However, proximate effects of temperature played an increasingly stronger role than intrinsic constraints for development time among species with colder natural incubation temperatures. Long development times of tropical birds have been thought to primarily reflect evolved physiological trade-offs that facilitate their greater longevity. In contrast, our results indicate a much stronger role of temperature in embryonic development time than currently thought.

  16. Physicochemical, Proximate and Sensory Properties of Pineapple (Ananas sp.) Syrup Developed from Its Organic Side-Stream

    NARCIS (Netherlands)

    Tortoe, C.; Johnson, P.N.T.; Slaghek, T.; Miedema, M.; Timmermans, T.

    2013-01-01

    A major economical industrial challenge from pineapple (Ananas sp.) processing contributing to environmental pollu- tion is the organic side-streams of pineapple. The physicochemical, proximate and sensory properties of organic side- stream pineapple syrup (OSPS) developed from Smooth cayenne, Sugar

  17. Toward Consistent Methodology to Quantify Populations in Proximity to Oil and Gas Development: A National Spatial Analysis and Review.

    Science.gov (United States)

    Czolowski, Eliza D; Santoro, Renee L; Srebotnjak, Tanja; Shonkoff, Seth B C

    2017-08-23

    Higher risk of exposure to environmental health hazards near oil and gas wells has spurred interest in quantifying populations that live in proximity to oil and gas development. The available studies on this topic lack consistent methodology and ignore aspects of oil and gas development of value to public health-relevant assessment and decision-making. We aim to present a methodological framework for oil and gas development proximity studies grounded in an understanding of hydrocarbon geology and development techniques. We geospatially overlay locations of active oil and gas wells in the conterminous United States and Census data to estimate the population living in proximity to hydrocarbon development at the national and state levels. We compare our methods and findings with existing proximity studies. Nationally, we estimate that 17.6 million people live within 1,600m (∼1 mi) of at least one active oil and/or gas well. Three of the eight studies overestimate populations at risk from actively producing oil and gas wells by including wells without evidence of production or drilling completion and/or using inappropriate population allocation methods. The remaining five studies, by omitting conventional wells in regions dominated by historical conventional development, significantly underestimate populations at risk. The well inventory guidelines we present provide an improved methodology for hydrocarbon proximity studies by acknowledging the importance of both conventional and unconventional well counts as well as the relative exposure risks associated with different primary production categories (e.g., oil, wet gas, dry gas) and developmental stages of wells. https://doi.org/10.1289/EHP1535.

  18. Proximity credentials: A survey

    International Nuclear Information System (INIS)

    Wright, L.J.

    1987-04-01

    Credentials as a means of identifying individuals have traditionally been a photo badge and more recently, the coded credential. Another type of badge, the proximity credential, is making inroads in the personnel identification field. This badge can be read from a distance instead of being veiewed by a guard or inserted into a reading device. This report reviews proximity credentials, identifies the companies marketing or developing proximity credentials, and describes their respective credentials. 3 tabs

  19. Space Network Time Distribution and Synchronization Protocol Development for Mars Proximity Link

    Science.gov (United States)

    Woo, Simon S.; Gao, Jay L.; Mills, David

    2010-01-01

    Time distribution and synchronization in deep space network are challenging due to long propagation delays, spacecraft movements, and relativistic effects. Further, the Network Time Protocol (NTP) designed for terrestrial networks may not work properly in space. In this work, we consider the time distribution protocol based on time message exchanges similar to Network Time Protocol (NTP). We present the Proximity-1 Space Link Interleaved Time Synchronization (PITS) algorithm that can work with the CCSDS Proximity-1 Space Data Link Protocol. The PITS algorithm provides faster time synchronization via two-way time transfer over proximity links, improves scalability as the number of spacecraft increase, lowers storage space requirement for collecting time samples, and is robust against packet loss and duplication which underlying protocol mechanisms provide.

  20. Proximal Humerus

    NARCIS (Netherlands)

    Diercks, Ron L.; Bain, Gregory; Itoi, Eiji; Di Giacomo, Giovanni; Sugaya, Hiroyuki

    2015-01-01

    This chapter describes the bony structures of the proximal humerus. The proximal humerus is often regarded as consisting of four parts, which assists in understanding function and, more specially, describes the essential parts in reconstruction after fracture or in joint replacement. These are the

  1. A questão da periodização do desenvolvimento psicológico em Wallon e em Vigotski: alguns aspectos de duas teorias The issue of the periodization of psychological development in Wallon and in Vygotsky: aspects of two theories

    Directory of Open Access Journals (Sweden)

    Edival Sebastião Teixeira

    2003-12-01

    Full Text Available Este artigo apresenta alguns aspectos de duas teorias de desenvolvimento psicológico elaboradas sob a ótica do materialismo dialético: a de Henri Wallon e a de Lev Vigotski. O trabalho argumenta que o fato de esses autores terem desenvolvido suas pesquisas apoiados na mesma matriz filosófica propicia importantes aproximações entre eles. Entre os aspectos comuns, o artigo destaca: a recusa em enquadrar o desenvolvimento psicológico em esquemas rígidos, orientados segundo uma lógica linear; a concepção de que o psiquismo humano foi e continua sendo produzido historicamente pelos próprios homens no interior das relações que estabelecem entre si e com a natureza; a defesa feita por essas duas teorias quanto ao caráter constitutivo, portanto positivo, dos conflitos e alternâncias entre períodos críticos e estáveis que caracterizam o desenvolvimento psicológico; e, principalmente, o fato de ambos os autores ressaltarem que uma compreensão adequada do desenvolvimento exige uma análise desse processo em sua essência interna, isto é, uma análise dos condicionantes dos sintomas externos do desenvolvimento psicológico. Especificamente sobre a teoria walloniana, o artigo realça a idéia de que o desenvolvimento é marcado pelas alternâncias entre cognição e afeto e entre razão e emoção; em relação à concepção vigotskiana, o texto enfatiza que o estudo do desenvolvimento psicológico deve partir da análise da atividade da criança tal como ela se apresenta nas condições concretas de sua vida.This article presents some aspects of two theories of psychological development created from the viewpoint of the dialectical materialism: those of Henri Wallon and of Lev Vygotsky. The work argues that the fact that both these authors developed their theories from the same philosophical roots inspires important approximations between them. Among the aspects shared by these theories the text highlights: the refusal to frame the

  2. Development and testing of texture discriminators for the analysis of trabecular bone in proximal femur radiographs

    Energy Technology Data Exchange (ETDEWEB)

    Huber, M. B.; Carballido-Gamio, J.; Fritscher, K.; Schubert, R.; Haenni, M.; Hengg, C.; Majumdar, S.; Link, T. M. [Department of Radiology and Biomedical Imaging, University of California, 400 Parnassus Avenue, San Francisco, California 94143 (United States); University of Health Sciences, Medical Informatics and Technology, 6060 Hall (Austria); AO Development Institute, 7270 Davos Platz (Switzerland); Medical University Innsbruck, 6020 Innsbruck (Austria); Department of Radiology and Biomedical Imaging, University of California, 400 Parnassus Avenue, San Francisco, California 94143 (United States)

    2009-11-15

    Purpose: Texture analysis of femur radiographs may serve as a potential low cost technique to predict osteoporotic fracture risk and has received considerable attention in the past years. A further application of this technique may be the measurement of the quality of specific bone compartments to provide useful information for treatment of bone fractures. Two challenges of texture analysis are the selection of the best suitable texture measure and reproducible placement of regions of interest (ROIs). The goal of this in vitro study was to automatically place ROIs in radiographs of proximal femur specimens and to calculate correlations between various different texture analysis methods and the femurs' anchorage strength. Methods: Radiographs were obtained from 14 femoral specimens and bone mineral density (BMD) was measured in the femoral neck. Biomechanical testing was performed to assess the anchorage strength in terms of failure load, breakaway torque, and number of cycles. Images were segmented using a framework that is based on the usage of level sets and statistical in-shape models. Five ROIs were automatically placed in the head, upper and lower neck, trochanteric, and shaft compartment in an atlas subject. All other subjects were registered rigidly, affinely, and nonlinearly, and the resulting transformation was used to map the five ROIs onto the individual femora. Results: In each ROI, texture features were extracted using gray level co-occurence matrices (GLCM), third-order GLCM, morphological gradients (MGs), Minkowski dimensions (MDs), Minkowski functionals (MFs), Gaussian Markov random fields, and scaling index method (SIM). Coefficients of determination for each texture feature with parameters of anchorage strength were computed. In a stepwise multiregression analysis, the most predictive parameters were identified in different models. Texture features were highly correlated with anchorage strength estimated by the failure load of up to R{sup 2

  3. Development and testing of texture discriminators for the analysis of trabecular bone in proximal femur radiographs

    International Nuclear Information System (INIS)

    Huber, M. B.; Carballido-Gamio, J.; Fritscher, K.; Schubert, R.; Haenni, M.; Hengg, C.; Majumdar, S.; Link, T. M.

    2009-01-01

    Purpose: Texture analysis of femur radiographs may serve as a potential low cost technique to predict osteoporotic fracture risk and has received considerable attention in the past years. A further application of this technique may be the measurement of the quality of specific bone compartments to provide useful information for treatment of bone fractures. Two challenges of texture analysis are the selection of the best suitable texture measure and reproducible placement of regions of interest (ROIs). The goal of this in vitro study was to automatically place ROIs in radiographs of proximal femur specimens and to calculate correlations between various different texture analysis methods and the femurs' anchorage strength. Methods: Radiographs were obtained from 14 femoral specimens and bone mineral density (BMD) was measured in the femoral neck. Biomechanical testing was performed to assess the anchorage strength in terms of failure load, breakaway torque, and number of cycles. Images were segmented using a framework that is based on the usage of level sets and statistical in-shape models. Five ROIs were automatically placed in the head, upper and lower neck, trochanteric, and shaft compartment in an atlas subject. All other subjects were registered rigidly, affinely, and nonlinearly, and the resulting transformation was used to map the five ROIs onto the individual femora. Results: In each ROI, texture features were extracted using gray level co-occurence matrices (GLCM), third-order GLCM, morphological gradients (MGs), Minkowski dimensions (MDs), Minkowski functionals (MFs), Gaussian Markov random fields, and scaling index method (SIM). Coefficients of determination for each texture feature with parameters of anchorage strength were computed. In a stepwise multiregression analysis, the most predictive parameters were identified in different models. Texture features were highly correlated with anchorage strength estimated by the failure load of up to R 2 =0.61 (MF

  4. Rethinking Assessments: Creating a New Tool Using the Zone Of Proximal Development within a Cultural-Historical Framework

    Directory of Open Access Journals (Sweden)

    Minson V.,

    2016-12-01

    Full Text Available This paper presents a picture of the current theoretical positions and methods used to assess children’s development. A maturational understanding of development is seen to be predominately used to inform the assessment tools which track how children develop across the 0—5 age group. This paper proposes that with the movement towards a cultural-historical understanding of development, a tool following from this standpoint should be developed. It is envisaged that a new assessment tool will be developed from this analysis. A theoretical rationale is given to support why the Zone of Proximal Development can be used to identify the indicators of children’s actual and potential levels of development, moving away from age/level based testing. Developing an assessment tool aligned to the principles of the ZPD can offer alternative method to assess children’s development in a theoretically robust way, providing empirical evidence to rethink the methodologies of child development assessments.

  5. An Explication of Concordance between Man's Mental Structure and the Narrative Structure in the Light of Vygotsky's SCT

    Science.gov (United States)

    Azabdaftari, Behrooz

    2013-01-01

    This paper seeks to throw light on the concordance between man's mental structure and the structure of narrative with regard to Vygotsky's sociocultural theory. In so doing, the author first provides the backdrop of the literature on the topic by first explaining Vygotsky's approach to the genesis of mind, and then gives a synoptic account of the…

  6. Implementing the Zone of Proximal Development: From the Pedagogical Experiment to the Developmental Education System of Leonid Zankov

    Directory of Open Access Journals (Sweden)

    Liudmila G. GUSEVA

    2017-06-01

    Full Text Available This article overviews the theoretical and applied works of the psychologist and pedagogue Leonid Zankov. Zankov’s model of teaching is based on Vygotsky’s theory that appropriate teaching methods stimulate cognitive development, whose core notion is the Zone of Proximal Development. This educational psychology research was verified by large scale pedagogical experiments conducted in 1970s at public schools in Russia. Over several decades L.V. Zankov with co-workers and followers created the comprehensive system of developmental education for elementary school. The Zankov education system is used now at public schools in Russia. Its main principles and properties are described.

  7. Implementing the zone of proximal development: From the pedagogical experiment to the developmental education system of Leonid Zankov

    Directory of Open Access Journals (Sweden)

    Liudmila G. Guseva

    2017-06-01

    Full Text Available This article overviews the theoretical and applied works of the psychologist and pedagogue Leonid Zankov. Zankov’s model of teaching is based on Vygotsky’s theory that appropriate teaching methods stimulate cognitive development, whose core notion is the Zone of Proximal Development. This educational psychology research was verified by large scale pedagogical experiments conducted in 1970s at public schools in Russia. Over several decades L.V. Zankov with co-workers and followers created the comprehensive system of developmental education for elementary school. The Zankov education system is used now at public schools in Russia. Its main principles and properties are described.

  8. Theories of Childhood: An Introduction to Dewey, Montessori, Erikson, Piaget & Vygotsky, Second Edition

    Science.gov (United States)

    Mooney, Carol Garhart

    2013-01-01

    This best-selling resource provides clear, straightforward introductions to the foundational theories of John Dewey, Maria Montessori, Erik Erikson, Jean Piaget, and Lev Vygotsky. Each chapter highlights a theorist's work and includes insight on how the theory impacts teaching young children today. Discussion questions and suggested readings are…

  9. Remediation of Learning Disable Children Following L.S. Vygotsky's Approach

    Directory of Open Access Journals (Sweden)

    Janna M. Glozman

    2011-01-01

    Full Text Available The paper defines remediating education, its peculiarities against trasitional education, main tasks and principles, based upon the cultural-historical theory of L.S. Vygotsky. Base functional systems formed during remediation are discussed. Peculiarities of individual, group and dyadic methods of remediation are described with regard to its potential for mediating child's activity.

  10. Vygotsky Meets Technology: A Reinvention of Collaboration in the Early Childhood Mathematics Classroom

    Science.gov (United States)

    Cicconi, Megan

    2014-01-01

    With the advent of Web 2.0, Vygotsky's traditional role of the more knowledgeable other (MKO) has been transformed. This transformation shifts the power of a facilitator of learning from an elite group of MKOs to all students. Such a transformation possesses significant value in the early childhood mathematics classroom where collaboration is…

  11. Another Woman Gets Robbed? What Jung, Freud, Piaget, and Vygotsky Took from Sabina Spielrein

    Science.gov (United States)

    Aldridge, Jerry

    2009-01-01

    Certainly not as many who have heard the names of Carl Jung, Sigmund Freud, Jean Piaget, and Lev Vygotsky, have heard of Sabina Spielrein. While Spielrein had numerous face-to-face encounters, some personal and some professional, with all four men, and the accounting of her life and the interactions she had with them has been the content of…

  12. Beneath Higher Ground: Vygotsky, Volosinov, and an Archaeology of Reported Speech in Primary EFL Writing

    Science.gov (United States)

    Yi, Jungran; Kellogg, David

    2006-01-01

    This study is a modest attempt to use three Korean primary school children and their English diaries as go-betweens to mediate in an apparent dispute between the founding fathers of socio-cultural theory about the nature of language and language awareness. According to Bruner, Vygotsky holds that mediation by others and self-mediation of written…

  13. Vygotsky's Stage Theory: The Psychology of Art and the Actor under the Direction of "Perezhivanie"

    Science.gov (United States)

    Smagorinsky, Peter

    2011-01-01

    This article reviews Vygotsky's writings on arts (particularly logocentric art including the theater) and emotions, drawing on his initial exploration in "The Psychology of Art" and his final considerations set forth in a set of essays, treatises, and lectures produced in the last years of his life. The review of "The Psychology of Art" includes…

  14. O pensamento de Vygotsky nas reuniões da ANPEd (1998-2003 Vygotsky's thought in the ANPEd meetings (1998 - 2003

    Directory of Open Access Journals (Sweden)

    Maria Teresa de Assunção Freitas

    2004-04-01

    Full Text Available Este artigo analisa os trabalhos fundamentados no pensamento de Vygotsky encontrados da 21ª até a 26ª Reunião Anual da ANPEd, no período de 1998 a 2003, com o objetivo de compreender como esse referencial teórico está sendo apropriado pelos autores participantes desse evento da área da Educação. O texto está organizado em três partes. Em primeiro lugar descreve-se o processo da pesquisa. Em seguida, são apresentados e discutidos os dados quantitativos do material analisado, presentes nas tabelas que figuram em anexo. A terceira parte se constitui em uma análise qualitativa, na qual se explicitam que referências bibliográficas são as mais utilizadas nos trabalhos examinados, que temas e conceitos da abordagem vygotskiana predominam nessa produção e a apropriação da teoria revelada nos textos. Nessa parte são destacados alguns trabalhos em especial, que parecem oferecer uma contribuição mais valiosa para a construção do conhecimento nesse campo, avançando teoricamente e expandindo os conceitos originais do autor em questão. Conclui-se o artigo tecendo algumas reflexões sobre a atual apropriação do pensamento de Vygotsky, revelada nos trabalhos analisados, dialogando com a tese de doutorado da autora, realizada doze anos atrás, que, abordando a mesma temática, focalizou a chegada dos autores da abordagem histórico-cultural no Brasil, o começo da difusão de suas idéias e os esforços iniciais de incorporação de seus conceitos. Finalmente, levantam-se algumas implicações que o estudo feito pode trazer para os educadores brasileiros e estudiosos de Vygotsky.This article analyzes the works based on Vygotsky's thought presented at the annual ANPEd (National Association for Graduate Studies and Research in Education meetings from 1998 to 2003, aiming at an understanding of how that theoretical framework is being incorporated by the authors that participate in those events. The text is organized into three parts

  15. Development of a living membrane comprising a functional human renal proximal tubule cell monolayer on polyethersulfone polymeric membrane.

    Science.gov (United States)

    Schophuizen, Carolien M S; De Napoli, Ilaria E; Jansen, Jitske; Teixeira, Sandra; Wilmer, Martijn J; Hoenderop, Joost G J; Van den Heuvel, Lambert P W; Masereeuw, Rosalinde; Stamatialis, Dimitrios

    2015-03-01

    The need for improved renal replacement therapies has stimulated innovative research for the development of a cell-based renal assist device. A key requirement for such a device is the formation of a "living membrane", consisting of a tight kidney cell monolayer with preserved functional organic ion transporters on a suitable artificial membrane surface. In this work, we applied a unique conditionally immortalized proximal tubule epithelial cell (ciPTEC) line with an optimized coating strategy on polyethersulfone (PES) membranes to develop a living membrane with a functional proximal tubule epithelial cell layer. PES membranes were coated with combinations of 3,4-dihydroxy-l-phenylalanine and human collagen IV (Coll IV). The optimal coating time and concentrations were determined to achieve retention of vital blood components while preserving high water transport and optimal ciPTEC adhesion. The ciPTEC monolayers obtained were examined through immunocytochemistry to detect zona occludens 1 tight junction proteins. Reproducible monolayers were formed when using a combination of 2 mg ml(-1) 3,4-dihydroxy-l-phenylalanine (4 min coating, 1h dissolution) and 25 μg ml(-1) Coll IV (4 min coating). The successful transport of (14)C-creatinine through the developed living membrane system was used as an indication for organic cation transporter functionality. The addition of metformin or cimetidine significantly reduced the creatinine transepithelial flux, indicating active creatinine uptake in ciPTECs, most likely mediated by the organic cation transporter, OCT2 (SLC22A2). In conclusion, this study shows the successful development of a living membrane consisting of a reproducible ciPTEC monolayer on PES membranes, an important step towards the development of a bioartificial kidney. Copyright © 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

  16. Axonal regeneration and development of de novo axons from distal dendrites of adult feline commissural interneurons after a proximal axotomy

    DEFF Research Database (Denmark)

    Fenrich, Keith K; Skelton, Nicole; MacDermid, Victoria E

    2007-01-01

    Following proximal axotomy, several types of neurons sprout de novo axons from distal dendrites. These processes may represent a means of forming new circuits following spinal cord injury. However, it is not know whether mammalian spinal interneurons, axotomized as a result of a spinal cord injury......, develop de novo axons. Our goal was to determine whether spinal commissural interneurons (CINs), axotomized by 3-4-mm midsagittal transection at C3, form de novo axons from distal dendrites. All experiments were performed on adult cats. CINs in C3 were stained with extracellular injections of Neurobiotin...... at 4-5 weeks post injury. The somata of axotomized CINs were identified by the presence of immunoreactivity for the axonal growth-associated protein-43 (GAP-43). Nearly half of the CINs had de novo axons that emerged from distal dendrites. These axons lacked immunoreactivity for the dendritic protein...

  17. Development and experimentation of LQR/APF guidance and control for autonomous proximity maneuvers of multiple spacecraft

    Science.gov (United States)

    Bevilacqua, R.; Lehmann, T.; Romano, M.

    2011-04-01

    This work introduces a novel control algorithm for close proximity multiple spacecraft autonomous maneuvers, based on hybrid linear quadratic regulator/artificial potential function (LQR/APF), for applications including autonomous docking, on-orbit assembly and spacecraft servicing. Both theoretical developments and experimental validation of the proposed approach are presented. Fuel consumption is sub-optimized in real-time through re-computation of the LQR at each sample time, while performing collision avoidance through the APF and a high level decisional logic. The underlying LQR/APF controller is integrated with a customized wall-following technique and a decisional logic, overcoming problems such as local minima. The algorithm is experimentally tested on a four spacecraft simulators test bed at the Spacecraft Robotics Laboratory of the Naval Postgraduate School. The metrics to evaluate the control algorithm are: autonomy of the system in making decisions, successful completion of the maneuver, required time, and propellant consumption.

  18. Lev Vygotsky between two revolutions: on the political self-determination of the scientist

    Directory of Open Access Journals (Sweden)

    Vladimir S. Sobkin

    2016-09-01

    Full Text Available The paper presented texts of the three previously unknown Lvygotsky’s journal notes and comments on them. These texts were published in mid-July and early September 1917 in the Jewish weekly «New Path» under the pseudonym «L.S.» and «W». In these texts, Lev Vygotsky describes the features of the political behaviour of the Jewish population in connection with the revolutionary events in Russia. On the one hand, a clear discrepancy between the activation of party work and political rhetoric is mentioned, and on the other hand, reduction of the significance of Jewish communal life is highlighted. As a key characteristic of social and psychological wellbeing of the Jewish population Vygotsky singles out absenteeism, i.e. the lack of interest in politics. Eventually the scientist captures the increase in uncertainty in the Jewish environment and fear of the future political, social and economic reforms in Russia. In the comments on Vygotsky notes, there are definitions relating to the various features of the activities of the Jewish political parties and public organizations, information about various policy documents and staff characterized by social and political situation before the elections in the Consituent Assembly (Uchreditel’noe Sobranie. Particular attention is paid to the analysis of stylistic and structural features of the commented text construction. By implicit quoting the relationship between Vygotsky’s texts and the works of other authors is identified. Particular attention is paid to the author’s attitude to religious texts, which allows to select a characteristic feature of the «double vision» of real events of the revolution against the background of the Jewish history. The comments help to single out features of the political identity of the young Lev Vygotsky in the period between the two revolutions, which is important to study his biography and understanding of his world view.

  19. Durkheim, Vygotsky e o currículo do futuro Durkheim, Vigotsky and the curriculum

    Directory of Open Access Journals (Sweden)

    Michael F. D. Young

    2002-11-01

    Full Text Available Este artigo reporta-se às bases epistemológicas do currículo do futuro. Inicia examinando os debates em curso sobre o impacto das mudanças curriculares na economia global. A parte principal do texto refere-se à explicação e comparação de duas teorias sociais do conhecimento - a de Emile Durkheim e a do psicólogo russo Lev Vygotsky, focalizando particularmente a questão das origens do conhecimento e a relação entre o conhecimento cotidiano e o conhecimento teórico. O autor argumenta que a abordagem genético-histórica adotada por Vygotsky precisa ser combinada com a ênfase durkheimiana na realidade social do conhecimento. Finalmente, conclui com algumas observações acerca das implicações da comparação para a teoria de currículo contemporânea.This article is concerned with the epistemological basics of the curriculum of the future. It begins by examining current debates on the impact on the curriculum of changes in the global economy. The major part of the paper is concerned with an explication and comparison of two social theories of knowledge - those of Emile Durkheim and the Russian psychologist Lev Vygotsky, with a particular focus on the concern with the origins of knowledge and the relationship between everyday and theoretical knowledge. It argues that the genetic/historical approach adopted by Vygotsky needs to be combined with Durkheim's focus on the social reality of knowledge itself. It concludes with some observations on the implications of the comparison for contemporary curriculum theory.

  20. Applications of electromagnetic principles in the design and development of proximity wireless sensors

    Science.gov (United States)

    Alam, Md Nazmul

    Sensors and sensing system are playing dominant roles in monitoring the health of infrastructure, such as bridges, power lines, gas pipelines, rail roads etc. Sensing modalities employing Surface Acoustic Waves (SAW), Electromagnetic (EM) and optical have been investigated and reported. Sensors that utilize the perturbation of EM fields as function of the change in the physical structural or material phenomenon are of particular interest because of their inherent synergy with electronic system and diagnostic techniques, e.g. Time Domain Reflectometry (TDR), Joint-Time-Frequency-Domain-Reflectometry (JTFDR). The focus of this work is to study and develop new sensing and monitoring concepts that are based on EM principles. First, the analyses, design and development of a static electric field type sensor are presented for application in embedded concrete moisture content measurement. The analytical formulation and results based on conformal mapping method for an interdigitated sensor clearly show the dependency of the field penetration depth and the inter-electrode capacitance on the electrode sizes and their spacings. It is observed that larger electrode size and small separation are needed in order to achieve substantially higher capacitance or large field penetration depth. A meander and a circular sensor are fabricated and tested to demonstrate concrete moisture content measurements that show that moisture content is a linear function of sensor interelectrode capacitance. Second, sub-wavelength dimension non-intrusive wave launchers are designed and tested that can launch TDR or JTFDR type broadband surface wave waveforms in the VHF-UHF bands in order to detect cable faults. Greater than 3:1 transmission bandwidth (100-300 MHz) is obtained with a cylindrical launcher on square orthogonal ground plane while with a CSW launcher more than an octave (100-240 MHz) bandwidth is achieved. Open circuit faults are detected using surface waves and TDR on two XLPE cables

  1. Em busca das bases ontológicas da psicologia de Vygotsky

    Directory of Open Access Journals (Sweden)

    Francisca Maurilene do Carmo

    2013-12-01

    Full Text Available O estudo busca estabelecer os fundamentos ontológicos do pensamento de Vygotsky, indicando que a construção teórica erigida pelo e autor está centrada no trabalho, como o complexo que deu origem ao homem como ser social. Tal postulado seria consistente com os princípios do marxismo recuperado por Lukács como uma ontologia do ser social, superadora da tradição metafísica e idealista, firmando, nesse sentido, o caráter radicalmente histórico da essência humana. Apontam-se os equívocos fundamentais operado pelo neovygotskianismo, o qual, tratando as categorias vygotskianas da linguagem, cultura e interação apartadas do princípio marxiano do trabalho, acaba por isolar Vygotsky do campo ontológico e, por extensão, do projeto socialista. Reafirma-se, por fim, que, não obstante a explícita relevância atribuída à dimensão metodológica do marxismo, está pressuposto na obra de Vygotsky, o substrato ontológico sobre o qual se funda o método de Marx.

  2. Phosphate transport in pig proximal small intestines during postnatal development: lack of modulation by calcitriol.

    Science.gov (United States)

    Schröder, B; Hattenhauer, O; Breves, G

    1998-04-01

    The role of calcitriol in the intestinal absorption of inorganic phosphate (Pi) during postnatal development was studied in newborn [6 weeks pp) control piglets (con) and piglets suffering from inherited calcitriol deficiency (def). In addition, a number of def piglets were treated with vitamin D3 (def-D3). Regardless of age, plasma calcitriol concentrations in def piglets were unphysiologically low (16-21 pg/ml) and differed significantly from those in respective con animals (60-69 pg/ml) and vitamin D3-treated def piglets (50-56 pg/ml). However, newborn and suckling def piglets had normal Ca (approximately 3.0 mmol/liter) and Pi (approximately 2.8 mmol/liter) plasma levels. Def piglets became hypocalcemic (1.9 mmol/liter) and hypophosphatemic (1.9 mmol/liter) between 4-6 weeks pp. Treatment with vitamin D3 significantly increased plasma Ca (3.2 mmol/liter) and Pi (2.7 mmol/liter) levels in weaned def animals. Regardless of calcitriol status, net Pi flux rates (active Pi absorption, as determined with the in vitro Ussing-chamber technique) from the upper small intestines was maximal at birth [170-224 nmol/(cm2 x h)] and decreased by approximately 80% during the first week of life before remaining constant [30-50 nmol/(cm2 x h)] during the following development. In weaned def piglets, net Pi flux rates were significantly lower by about 80% compared with those in con animals. Treatment of def piglets with vitamin D3 had no effect in newborn and suckling animals but reconstituted net Pi flux rates to normal values at weaning age. Age-dependent and calcitriol-mediated changes in net Pi flux rates were paralleled by respective maximum velocity values of Na+-dependent Pi uptake across the brush border membrane of the enterocytes (newborn piglets, 1.9-2.2 nmol/(mg protein 10 sec); suckling piglets, 0.4-0.6 nmol/(mg protein x 10 sec); weaned piglets, 0.7, 0.3, and 0.7 nmol/(mg protein x 10 sec) in con, def, and def-D3 animals, respectively). These findings suggest that

  3. International Symposium: “Scientific School of L.S. Vygotsky: Traditions and Innovations” and International ISCAR Summer University for PhD Students

    Directory of Open Access Journals (Sweden)

    Baykovskaya N.A.,

    2016-12-01

    Full Text Available The article represents a brief report on the work of the International Symposium: «Scientific School of L.S. Vygotsky: Traditions and Innovations» and VI th International ISCAR Summer University for PhD Students and young scholars, that were held in Moscow State University of Psychology & Education on June, 28 — July, 3 in 2016 in commemoration of the 120th anniversary of the great Russian psychologist L.S. Vygotsky. The main goals of the events organised by MSUPE include: analysis of the basic principles and the system of concepts of L.S. Vygotsky’s scientific school, discussion of the current state and the prospect for the development of the cultural-historical theory in Russia and abroad, integration of the ideas of the cultural-historical psychology and activity approach in various kinds of social and educational practices, as well as conducting research in the international scientific space. Symposium gathered the world’s leading experts and young scholars in the field of cultural-historical theory and activity approach from 19 countries, including United Kingdom, Australia, Switzerland, Greece, Brasil and USA.

  4. Exploring the determinants of health and wellbeing in communities living in proximity to coal seam gas developments in regional Queensland.

    Science.gov (United States)

    Mactaggart, Fiona; McDermott, Liane; Tynan, Anna; Gericke, Christian A

    2017-08-03

    There is some concern that coal seam gas mining may affect health and wellbeing through changes in social determinants such as living and working conditions, local economy and the environment. The onward impact of these conditions on health and wellbeing is often not monitored to the same degree as direct environmental health impacts in the mining context, but merits attention. This study reports on the findings from a recurrent theme that emerged from analysis of the qualitative component of a comprehensive Health Needs Assessment (HNA) conducted in regional Queensland: that health and wellbeing of communities was reportedly affected by nearby coal seam gas (CSG) development beyond direct environmental impacts. Qualitative analysis was initially completed using the Framework Method to explore key themes from 11 focus group discussions, 19 in-depth interviews, and 45 key informant interviews with health and wellbeing service providers and community members. A key theme emerged from the analysis that forms the basis of this paper. This study is part of a larger comprehensive HNA involving qualitative and quantitative data collection to explore the health and wellbeing needs of three communities living in proximity to CSG development in regional Queensland, Australia. Communities faced social, economic and environmental impacts from the rapid growth of CSG development, which were perceived to have direct and indirect effects on individual lifestyle factors such as alcohol and drug abuse, family relationships, social capital and mental health; and community-level factors including social connectedness, civic engagement and trust. Outer regional communities discussed the effects of mining activity on the fabric of their town and community, whereas the inner regional community that had a longer history of industrial activity discussed the impacts on families and individual health and wellbeing. The findings from this study may inform future health service planning in

  5. Exploring the determinants of health and wellbeing in communities living in proximity to coal seam gas developments in regional Queensland

    Directory of Open Access Journals (Sweden)

    Fiona Mactaggart

    2017-08-01

    Full Text Available Abstract Background There is some concern that coal seam gas mining may affect health and wellbeing through changes in social determinants such as living and working conditions, local economy and the environment. The onward impact of these conditions on health and wellbeing is often not monitored to the same degree as direct environmental health impacts in the mining context, but merits attention. This study reports on the findings from a recurrent theme that emerged from analysis of the qualitative component of a comprehensive Health Needs Assessment (HNA conducted in regional Queensland: that health and wellbeing of communities was reportedly affected by nearby coal seam gas (CSG development beyond direct environmental impacts. Methods Qualitative analysis was initially completed using the Framework Method to explore key themes from 11 focus group discussions, 19 in-depth interviews, and 45 key informant interviews with health and wellbeing service providers and community members. A key theme emerged from the analysis that forms the basis of this paper. This study is part of a larger comprehensive HNA involving qualitative and quantitative data collection to explore the health and wellbeing needs of three communities living in proximity to CSG development in regional Queensland, Australia. Results Communities faced social, economic and environmental impacts from the rapid growth of CSG development, which were perceived to have direct and indirect effects on individual lifestyle factors such as alcohol and drug abuse, family relationships, social capital and mental health; and community-level factors including social connectedness, civic engagement and trust. Conclusions Outer regional communities discussed the effects of mining activity on the fabric of their town and community, whereas the inner regional community that had a longer history of industrial activity discussed the impacts on families and individual health and wellbeing. The

  6. Vygotski e Sartre: aproximando concepções metodológicas na construção do saber psicológico Vygotski and Sartre: approaching methodological conceptions in the construction of psychological knowledge

    Directory of Open Access Journals (Sweden)

    Kátia Maheirie

    2007-04-01

    Full Text Available Para apontar contribuições metodológicas de Sartre e Vygotski à Psicologia, este artigo recupera as obras: "O significado histórico da crise da psicologia. Uma investigação metodológica" (Vygotski, 1996 e "Questão de método" (Sartre, 1960/1987. Em seu texto, Vygotski identifica uma crise na Psicologia daquele tempo, indicando sua superação por uma abordagem metodológica calcada nas reflexões de Marx. Também Sartre retorna aos escritos marxianos, visando o sujeito como singularidade irredutível que se constitui nas relações sociais. Finalmente, Sartre e Vygotski defendem posturas metodológicas que abarquem, simultaneamente, o sujeito ímpar e a totalização histórica inacabada em que se faz. Cada autor, a sua maneira, advoga a especificidade que caracteriza o humano, concebendo a subjetividade na relação com a objetividade, num movimento dialético incessante. Entendendo o sujeito como produto e produtor da cultura, os autores podem colaborar para uma psicologia comprometida com seu contexto político, porque orientada por uma perspectiva de transformação social.This article aims to point out Vygotsky's and Sartre's methodological contributions to psychology, using the following literature: "O significado histórico da crise da psicologia. Uma investigação metodológica" (Vygotsky, 1996 and "Questão de Método" (Sartre, 1987. Vygotsky identifies a psychological crisis, indicating that to overcome it depends on a methodological approach based on Marx's thoughts. Sartre also returns to Marx's writings, to define the subject as an irreducible singularity which is constituted on social relations. Finally, Sartre and Vygotsky share a methodological position which comprehends, simultaneously, the singularity of human beings and its unfinished historical totalizing process. Each author, in his own way, assumes specificities that characterize the human being, conceiving subjectivity in an incessant and dialectic relation with

  7. Piaget, Vygotsky e Wallon: contribuições para os estudos da linguagem

    Directory of Open Access Journals (Sweden)

    Caciana Linhares Pereira

    2012-06-01

    Full Text Available O presente artigo aborda alguns aspectos da relação entre linguagem e pensamento na criança a partir das teorias de Piaget, Vygotsky e Wallon. Os aspectos analisados nos permitem situar estes autores no debate - tipicamente moderno - que envolve as complexas relações entre linguagem e pensamento. Constata-se que a modernidade do pensamento dos três autores comparece, sobretudo, no abandono de uma perspectiva instrumental da linguagem e no estabelecimento de proposições que tomam a linguagem como uma função constitutiva do próprio pensamento.

  8. Vygotsky e a Mediação Computacional no Processo Educacional

    Directory of Open Access Journals (Sweden)

    Maria Stela de A. Albuquerque Bergo

    2007-06-01

    Full Text Available Este artigo aborda a questão da comunicação mediada pelo computador no contexto educacional, tendo por base os conceitos de Vygotsky e Luria, e as abordagens afins que ajudam a explicar o processo e a prever conseqüências dessa prática. O aperfeiçoamento de novos recursos educacionais, desenvolvidos para computadores, bem como o advento da Internet, modificam e sofrem as modificações nas comunicações mediadas por esse novo instrumento. O artigo aponta alguns tópicos a serem analisados pelos interessados sobre o assunto.

  9. More than a Footnote to History in Cultural-Historical Theory: The Zalkind Summary, Experimental Study of Higher Behavioural Processes, and "Vygotsky's Blocks"

    Science.gov (United States)

    Towsey, Paula M.

    2009-01-01

    This article presents what is possibly the first English translation of a 1930 manuscript related to Vygotsky's work (probably written by Vygotsky himself). This manuscript, the Zalkind Summary, is a five-point summary of his presentation to the First All-Union Congress on the Study of Human Behaviour in Leningrad in January 1930. This article…

  10. Quantum Proximity Resonances

    International Nuclear Information System (INIS)

    Heller, E.J.

    1996-01-01

    It is well known that at long wavelengths λ an s-wave scatterer can have a scattering cross section σ on the order of λ 2 , much larger than its physical size, as measured by the range of its potential. Very interesting phenomena can arise when two or more identical scatterers are placed close together, well within one wavelength. We show that, for a pair of identical scatterers, an extremely narrow p-wave open-quote open-quote proximity close-quote close-quote resonance develops from a broader s-wave resonance of the individual scatterers. A new s-wave resonance of the pair also appears. The relation of these proximity resonances (so called because they appear when the scatterers are close together) to the Thomas and Efimov effects is discussed. copyright 1996 The American Physical Society

  11. Play and Self-Regulation: Lessons from Vygotsky

    Science.gov (United States)

    Bodrova, Elena; Germeroth, Carrie; Leong, Deborah J.

    2013-01-01

    The authors consider the analysis of the literature on play research by Lillard and others in the January 2013 "Psychological Bulletin," an analysis that questioned the prevailing assumption of a causal relationship between play and child development, especially in the areas of creativity, reasoning, executive function, and regulation of…

  12. Where Vygotsky Meets Piaget: American Educational Television Goes to Russia

    OpenAIRE

    Price, Alison E.

    1996-01-01

    A discussion of the current effort to develop a Russian version of the acclaimed American educational television program Sesame Street highlights some fundamental differences between American and Russian educational philosophies and research methods. The program’s producers have shown much sensitivity in their willingness to adapt the show to local conditions; yet there are many features and ideas implicit in the program that conflict with Russian views on education and research. Thus Russian...

  13. L.S. Vygotsky in the 21st century

    Directory of Open Access Journals (Sweden)

    Ardila A.

    2016-12-01

    Full Text Available Although Lev Vygotsky’s interpretation of human cognition was proposed almost one century ago, new scientific and technological advances have significantly supported many of his ideas and hypotheses. His cultural-historical theory of psychological processes, and his contributions to educational psychology, have continued growing without interruption. In this paper, three of Vygotsky’s hypotheses are examined in light of 21st century scientific developments: The influence of cultural factors on human cognition. A diversity of research studies in different countries has corroborated the crucial impact of culture on cognitive test performance; The role of language in higher psychological processes. According to Vygotsky’s cultural-historical approach, cognitive processes (“complex psychological processes” are social in origin, but complex and hierarchical in their structure. Intrinsic to the systemic organization of higher cognitive processes is the engagement of external artifacts (objects, symbols, signs, which have an independent history of development within a culture; and The hypothesis that thought and general complex cognition is associated with certain “inner speech.” Some contemporary neuroimaging studies (particularly PET and fMRI analyzing “inner speech” have been carried out. These studies have attempted to find the areas of the brain involved in “inner speech.” These scientific advances significantly support Vygotsky’s interpretation of human cognition. It has been found that inner speech depends on activity in Broca’s area and related brain network activity in the left hemisphere. Hence, inner speech is closely related to grammar, language production, and executive functions. Vygotsky’s important contribution to the understanding of psychological processes has stimulated, and continues to stimulate, a substantial amount of research in this area.

  14. Before the "boom": Readings and uses of Vygotsky in Argentina (1935-1974).

    Science.gov (United States)

    García, Luciano Nicolás

    2016-11-01

    This article analyzes, from the standpoint of reception studies and transnational history, the different ways Lev S. Vygotsky's published work in Spanish, English, and Russian was read, discussed, and used in Argentina from 1935 to 1974. This "early" reception primarily involved 2 groups: writers affiliated with the Argentine Communist Party, and individuals without political affiliations who engaged in discussion with Communists. The article argues that Communism, as a cultural tradition and political organization, played a key role in the reception and diffusion of Vygotsky's work. The ideas of the Soviet psychologist were applied in 3 different areas: the psychophysiological theorizing of consciousness, the diagnosis and treatment of dyslexia, and the study of psychiatric phenomena. This article partially reconstructs the circulation of Soviet psychology in Argentina in order to provide a critical approach regarding the inclusion of certain figures in the psychological canon, the methods by which these authors have been researched in the past, the means that enable the circulation of psychological knowledge, and the ways in which the political and intellectual milieu of reception define the productivity and relevance of an author. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  15. Comprensión del significado desde Vygotsky, Bruner y Gergen

    Directory of Open Access Journals (Sweden)

    Paola Andrea Arcila Mendoza

    2010-01-01

    Full Text Available Este artículo es producto de la investigación "El significado desde Lev Semionovich Vygotsky, Jerome Bruner y Kenneth Gergen". Su pretensión es comprender los conceptos de "significado" construidos por estos autores mediante la revisión de varias de sus obras más importantes. El método de investigación utilizado fue el análisis de contenido. También se realizó una meta-observación sobre el trabajo, una vez éste estuvo concluido, lo que requirió establecer nuevas relaciones entre los autores. El análisis permitió descubrir diferencias y puntos de consenso entre los tres autores, en cuanto a la definición de significado, la explicación de su origen y evolución y la delimitación de las funciones que cumple en los seres humanos. Como idea original en Vygotsky se resalta el paso de la significación interpsicológica a la intrapsicológica; en Bruner, la constante negociación de significados entre seres humanos inmersos en una cultura; y en Gergen, la construcción relacional de los significados.

  16. Cotidiano, mediação pedagógica e formação de conceitos: uma contribuição de Vygotsky ao ensino de geografia

    Directory of Open Access Journals (Sweden)

    Lana de Souza Cavalcanti

    Full Text Available Este texto faz uma síntese da teoria vygotskyana sobre o desenvolvimento dos processos psicológicos superiores, destacando alguns conceitos dessa teoria, tais como internalização, mediação semiótica, Zona de Desenvolvimento Proximal, conceitos cotidianos e conceitos científicos, que são especialmente instrumentalizadores da análise dos processos educativos e de sua relação com o desenvolvimento dos processos psicológicos. A partir de uma síntese do pensamento de Vygotsky, o texto busca especificar possíveis contribuições dessa teoria para o ensino de geografia, particularmente para a formação de conceitos geográficos.

  17. Organic anion and cation SLC22 "drug" transporter (Oat1, Oat3, and Oct1 regulation during development and maturation of the kidney proximal tubule.

    Directory of Open Access Journals (Sweden)

    Thomas F Gallegos

    Full Text Available Proper physiological function in the pre- and post-natal proximal tubule of the kidney depends upon the acquisition of selective permeability, apical-basolateral epithelial polarity and the expression of key transporters, including those involved in metabolite, toxin and drug handling. Particularly important are the SLC22 family of transporters, including the organic anion transporters Oat1 (originally identified as NKT and Oat3 as well as the organic cation transporter Oct1. In ex vivo cultures of metanephric mesenchyme (MM; the embryonic progenitor tissue of the nephron Oat function was evident before completion of nephron segmentation and corresponded with the maturation of tight junctions as measured biochemically by detergent extractability of the tight junction protein, ZO-1. Examination of available time series microarray data sets in the context of development and differentiation of the proximal tubule (derived from both in vivo and in vitro/ex vivo developing nephrons allowed for correlation of gene expression data to biochemically and functionally defined states of development. This bioinformatic analysis yielded a network of genes with connectivity biased toward Hnf4α (but including Hnf1α, hyaluronic acid-CD44, and notch pathways. Intriguingly, the Oat1 and Oat3 genes were found to have strong temporal co-expression with Hnf4α in the cultured MM supporting the notion of some connection between the transporters and this transcription factor. Taken together with the ChIP-qPCR finding that Hnf4α occupies Oat1, Oat3, and Oct1 proximal promoters in the in vivo differentiating rat kidney, the data suggest a network of genes with Hnf4α at its center plays a role in regulating the terminal differentiation and capacity for drug and toxin handling by the nascent proximal tubule of the kidney.

  18. Learning within the Worlds of Reifications, Selves, and Phenomena: Expanding on the Thinking of Vygotsky and Popper

    Science.gov (United States)

    Hung, David Wei Loong; Chen, Der-Thanq

    2008-01-01

    A framework, termed the RSP, is proposed. It is mainly for analyzing and explaining how learning occurs. This framework is grounded in the social-cultural perspective, in particular, in the thinking of both Vygotsky and Popper. Although the thinking of Popper is generally not referred to as having a social-cultural orientation, mostly due to…

  19. Introducing Computers to Kindergarten Children Based on Vygotsky's Theory about Socio-Cultural Learning: The Greek Perspective.

    Science.gov (United States)

    Pange, Jenny; Kontozisis, Dimitrios

    2001-01-01

    Greek preschoolers' level of knowledge about computers was examined as they participated in a classroom project to introduce them to new technologies. The project was based on Vygotsky's theory of socio-cultural learning. Findings suggest that this approach is a successful way to introduce new technologies to young children. (JPB)

  20. Knowledge for Teaching and Knowledge to Teach: Two Contrasting Figures of New Education--Claparede and Vygotsky

    Science.gov (United States)

    Hofstetter, Rita; Schneuwly, Bernard

    2009-01-01

    The debate on knowledge in New Education is generally dominated by two opposed Anglo-Saxon positions held by Dewey and Thorndike. This paper presents another line of division. Claparede and Vygotsky, two representative European figures of New Education are both scientists constructing a theory of psychological functioning, and heavily engaged in…

  1. Spinal Implant Density and Postoperative Lumbar Lordosis as Predictors for the Development of Proximal Junctional Kyphosis in Adult Spinal Deformity.

    Science.gov (United States)

    McClendon, Jamal; Smith, Timothy R; Sugrue, Patrick A; Thompson, Sara E; O'Shaughnessy, Brian A; Koski, Tyler R

    2016-11-01

    To evaluate spinal implant density and proximal junctional kyphosis (PJK) in adult spinal deformity (ASD). Consecutive patients with ASD receiving ≥5 level fusions were retrospectively analyzed between 2007 and 2010. ASD, elective fusions, minimum 2-year follow-up. age lordosis (LL) were predictors for PJK (P = 0.018 and 0.045, respectively). Controlling for age, BMI, and gender, postoperative LL (not implant density) continued to show significance in multivariate logistic regression model. PJK, although influenced by a multitude of factors, may be statistically related to implant density and LL. Copyright © 2016. Published by Elsevier Inc.

  2. Children's proximal societal conditions

    DEFF Research Database (Denmark)

    Stanek, Anja Hvidtfeldt

    2018-01-01

    that is above or outside the institutional setting or the children’s everyday life, but something that is represented through societal structures and actual persons participating (in political ways) within the institutional settings, in ways that has meaning to children’s possibilities to participate, learn...... and develop. Understanding school or kindergarten as (part of) the children’s proximal societal conditions for development and learning, means for instance that considerations about an inclusive agenda are no longer simply thoughts about the school – for economic reasons – having space for as many pupils...... as possible (schools for all). Such thoughts can be supplemented by reflections about which version of ‘the societal’ we wish to present our children with, and which version of ‘the societal’ we wish to set up as the condition for children’s participation and development. The point is to clarify or sharpen...

  3. Proximity detection system underground

    Energy Technology Data Exchange (ETDEWEB)

    Denis Kent [Mine Site Technologies (Australia)

    2008-04-15

    Mine Site Technologies (MST) with the support ACARP and Xstrata Coal NSW, as well as assistance from Centennial Coal, has developed a Proximity Detection System to proof of concept stage as per plan. The basic aim of the project was to develop a system to reduce the risk of the people coming into contact with vehicles in an uncontrolled manner (i.e. being 'run over'). The potential to extend the developed technology into other areas, such as controls for vehicle-vehicle collisions and restricting access of vehicle or people into certain zones (e.g. non FLP vehicles into Hazardous Zones/ERZ) was also assessed. The project leveraged off MST's existing Intellectual Property and experience gained with our ImPact TRACKER tagging technology, allowing the development to be fast tracked. The basic concept developed uses active RFID Tags worn by miners underground to be detected by vehicle mounted Readers. These Readers in turn provide outputs that can be used to alert a driver (e.g. by light and/or audible alarm) that a person (Tag) approaching within their vicinity. The prototype/test kit developed proved the concept and technology, the four main components being: Active RFID Tags to send out signals for detection by vehicle mounted receivers; Receiver electronics to detect RFID Tags approaching within the vicinity of the unit to create a long range detection system (60 m to 120 m); A transmitting/exciter device to enable inner detection zone (within 5 m to 20 m); and A software/hardware device to process & log incoming Tags reads and create certain outputs. Tests undertaken in the laboratory and at a number of mine sites, confirmed the technology path taken could form the basis of a reliable Proximity Detection/Alert System.

  4. Development of miniaturized proximity focused streak tubes for visible light and x-ray applications. Final report and progress, April-September 1977

    International Nuclear Information System (INIS)

    Cuny, J.J.; Knight, A.J.

    1978-02-01

    Research performed to develop miniaturized proximity focused streak camera tubes (PFST) for application in the visible and the x-ray modes of operation is described. The objective of this research was to provide an engineering design and to fabricate a visible and an x-ray prototype tube to be provided to LASL for test and evaluation. Materials selection and fabrication procedures, particularly the joining of beryllium to a suitable support ring for use as the x-ray window, are described in detail. The visible and x-ray PFST's were successfully fabricated

  5. Proximal Probes Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Proximal Probes Facility consists of laboratories for microscopy, spectroscopy, and probing of nanostructured materials and their functional properties. At the...

  6. READING SLOW ART WORK AS A MOTION FOR AESTHETIC EDUCATION ON THE BASIS OF MARX AND VYGOTSKY CONTRIBUTIONS

    Directory of Open Access Journals (Sweden)

    Priscila de Souza Chiste

    2015-06-01

    Full Text Available The article signals a proposal for Aesthetic Education, from literature search, in dialogue with studies of Marx and Vygotsky. According to the Marxist theory presents reflections on aesthetics in the contemporary context and seeks to understand Vygotsky assumptions of Aesthetic Education. Suggests a path through the visual arts, to educate aesthetically from the concept of slow reading of the artwork. Considers that one of the possibilities to achieve such intent is to provide intense, diverse and ongoing encounters with works of art; mediate readings pictures that show both poetic and intertextual aspects as formal of these works, magnified by the knowledge of the artist's universe and the legitimation modes and dissemination of works and, finally, to propose matters relating to the interests of students.

  7. “Lines of Mourning”: On the Issue of National and Cultural Self-Determination of L.S. Vygotsky

    Directory of Open Access Journals (Sweden)

    Sobkin V.S.

    2017-08-01

    Full Text Available The paper presents the full text of a work by L.S. Vygotsky “Lines of Mourning” (1916 along with detailed commentaries. This article was the first of the three published in the Jewish periodical Noviy Put’ that can be considered a triptych dedicated to the issues of national, cultural and religious traditions and their relation with modern times. The text and commentaries provide an insight into personal meanings and attitudes of young Vygotsky in the situation of political and value/normative uncertainty. This enables us to reconstruct the features of social, political, national and ethic self-definition of the scientist and to reveal the grounds and values underlying the cultural-historical approach. Special attention is brought to the dialogic nature of the Jewish and Russian culture. In the commentaries we also focus on the specifics of artistic and reflective position of Vygotsky in relation to pre-revolutionary events that took place at that time: understanding this allows us to comprehend a whole set of social, political, moral, ethic and truly psychological problems that would later on be reflected in his scientific works. Another section of our commentaries is centered on the analysis of the article’s style and composition and its multi-layered structure.

  8. Construtivismo sócio-histórico de Vygostky e a enfermagem El constructivismo socio-historico de Vygotsky y la enfermería Vygotsky's social-historic constructivism and nursing

    Directory of Open Access Journals (Sweden)

    Maira Buss Thofehrn

    2006-10-01

    Full Text Available O presente artigo tem o propósito de refletir, no âmbito teórico, sobre o construtivismo sócio-histórico de Vygotsky e as contribuições deste estudioso russo para a construção do conhecimento da Enfermagem. A abordagem vygotskiana tem como pressupostos filosóficos, epistemológicos e metodológicos, os princípios do materialismo histórico, ênfase no contexto sócio-cultural no processo de trabalho, no uso de instrumentos e na interação dialética entre seres humanos e ambiente. Entendemos que as idéias preconizadas por este autor podem representar um método alternativo para os estudos teórico-práticos, especialmente, quanto à dimensão subjetiva do processo de trabalho junto à equipe de enfermagem.El presente artículo tiene el objetivo de reflexionar, en el ámbito teórico, respecto al constructivismo socio-histórico de Vygotsky y las contribuciones de ese estudioso ruso para la construcción del conocimiento de la enfermería. El abordaje vygotskiniano tiene como ejes filosóficos, epistemológicos y metodológicos, los principios del materialismo histórico, énfasis en el contexto sociocultural en el proceso de trabajo, en el uso de instrumentos y en la interacción dialéctica entre seres humanos y su entorno. Entendemos que las ideas preconizadas por Vygotsky pueden representar un método alternativo para los estudios teóricos-prácticos, especialmente, cuanto a la dimensión subjetiva del proceso de trabajo junto al equipo de enfermería.The aim of this paper is to reflect, in the theoretical scope, about the Vygotsky's socio-historical constructivism and the contributions from this Russian researcher to build the nursing knowledge. The Vygotskian approach has as its philosophical, epistemological and methodological purposes, the principles of the historical materialism, it emphasizes the social and cultural context in the working process, also in the use of instruments and in the dialectical interaction between

  9. Inside the Creative Sifter: Recognizing Metacognition in Creativity Development

    Science.gov (United States)

    Puryear, Jeb S.

    2016-01-01

    The parallels between cognitive development and creativity are neglected in the literature. Piaget's information transformations are personalized, meaning individual constructions can involve creativity. Vygotsky's work considers the implications and interactions of social influences, conventions, and personal implications for creative…

  10. The practical learning of the chemistry and the use of the signs of Tolman & Vygotsky

    Directory of Open Access Journals (Sweden)

    Enrique Antonio

    2011-09-01

    Full Text Available En este ensayo se discute que en el aprendizaje de las ciencias y en particular de la química, el laboratorio de ciencias es un elemento fundamental para la práctica. Tradicionalmente se ha señalado que la enseñanza de la práctica tiene intenciones de reforzar la enseñanza de la teoría, pero no todas las prácticas realizadas en el laboratorio cumplen con ese objetivo, ya que algunas prácticas son tipo receta con alcances educativos muy limitados como conocer o comprender, es así que, en función de los signos de Tolman y de Vygotsky, se proponen prácticas de laboratorio basadas más en la indagación científica en que se aborden situaciones problemáticas de interés y menos en la repetición de guiones preestablecidos.

  11. Development of a living membrane comprising of a functional human renal proximal tubule cell monolayer on polyethersulfone polymeric membrane

    NARCIS (Netherlands)

    Schophuizen, C.M.S.; De Napoli, Ilaria; Jansen, J.; Da Silva Teixeira, Sandra; Wilmer, M.; Hoenderop, J.G.; van den Heuvel, L.P.W.; Masereeuw, R.; Stamatialis, Dimitrios

    2015-01-01

    The need for improved renal replacement therapies has stimulated innovative research for the development of a cell-based renal assist device. A key requirement for such a device is the formation of a “living membrane”, consisting of a tight kidney cell monolayer with preserved functional organic ion

  12. What Happens to Children's Faith in the Zone of Proximal Development, and What Can Religious Educators Do about It?

    Science.gov (United States)

    Court, Deborah

    2010-01-01

    This article mingles stories and concepts of young Jewish Israeli children about God, with reflections on the roles of faith, memory, imagination, and cognitive development in children's Religious Education. The stories are meant to illustrate, among other things, the purity and innocence of young children's faith, which is largely untroubled by…

  13. [Development of the Feelings toward Nature Scale and relationship between feelings toward nature and proximity to nature].

    Science.gov (United States)

    Shibata, Seiji

    2016-04-01

    In the field of environmental psychology, there is rapidly growing interest in the concept of connectivity with nature, describing an individual's sense of being connected with nature. The author developed a new scale for assessing feelings toward nature, including connectedness. Confirmatory factor analysis indicated a five-factor model consisting of restorativeness, oneness, mystery, care, and aversion. Then, the relationships among availability of nature in respondents' neighborhood, age, and each subscale score of the Feelings toward Nature Scale, were analyzed using structural equation modeling. The availability of nature in neighborhoods was assessed using a geographic information system and respondents' subjective evaluations. Results indicate that overall connectedness to nature is weaker as availability of nature decreases, as assessed by subjective evaluation. Results also suggest that aversion toward nature in younger people is relatively stronger than in older generations.

  14. Vygotsky's Socio-cultural Theory of Literacy Scaffolding Children to Read and Write at an Early Age

    OpenAIRE

    Arshad, Mahzan; Chen, Wu Hsueh

    2009-01-01

    In the article the concept of semiotic mediation, appropriation, internalization,Zone of Proximal Development (ZPD) and scaffolding in particular werereviewed to provide understanding of the process. Under the concept ofsemiotic mediation, the issue of how children learn through imitating adults wasexamined with inputs from second language acquisition theories. Vygotsky’sconcept of appropriation provides the springboard for a discussion on howchildren may appropriate the psychological tool of...

  15. Neighborhoods and manageable proximity

    Directory of Open Access Journals (Sweden)

    Stavros Stavrides

    2011-08-01

    Full Text Available The theatricality of urban encounters is above all a theatricality of distances which allow for the encounter. The absolute “strangeness” of the crowd (Simmel 1997: 74 expressed, in its purest form, in the absolute proximity of a crowded subway train, does not generally allow for any movements of approach, but only for nervous hostile reactions and submissive hypnotic gestures. Neither forced intersections in the course of pedestrians or vehicles, nor the instantaneous crossing of distances by the technology of live broadcasting and remote control give birth to places of encounter. In the forced proximity of the metropolitan crowd which haunted the city of the 19th and 20th century, as well as in the forced proximity of the tele-presence which haunts the dystopic prospect of the future “omnipolis” (Virilio 1997: 74, the necessary distance, which is the stage of an encounter between different instances of otherness, is dissipated.

  16. Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: Implications for drug development and basic cytokine biology.

    Science.gov (United States)

    Tatzel, Katharina; Kuroki, Lindsay; Dmitriev, Igor; Kashentseva, Elena; Curiel, David T; Goedegebuure, S Peter; Powell, Matthew A; Mutch, David G; Hawkins, William G; Spitzer, Dirk

    2016-03-03

    TRAIL continues to garner substantial interest as a recombinant cancer therapeutic while the native cytokine itself serves important tumor surveillance functions when expressed in membrane-anchored form on activated immune effector cells. We have recently developed the genetically stabilized TRAIL platform TR3 in efforts to improve the limitations associated with currently available drug variants. While in the process of characterizing mesothelin-targeted TR3 variants using a single chain antibody (scFv) delivery format (SS-TR3), we discovered that the membrane-tethered cytokine had a substantially increased activity profile compared to non-targeted TR3. However, cell death proceeded exclusively via a bystander mechanism and protected the mesothelin-positive targets from apoptosis rather than leading to their elimination. Incorporation of a spacer-into the mesothelin surface antigen or the cancer drug itself-converted SS-TR3 into a cis-acting phenotype. Further experiments with membrane-anchored TR3 variants and the native cytokine confirmed our hypothesis that membrane-proximal TRAIL species lack the capacity to physically engage their cognate receptors coexpressed on the same cell membrane. Our findings not only provide an explanation for the "peaceful" coexistence of ligand and receptor of a representative member of the TNF superfamily but give us vital clues for the design of activity-enhanced TR3-based cancer therapeutics.

  17. Proximal collagenous gastroenteritides:

    DEFF Research Database (Denmark)

    Nielsen, Ole Haagen; Riis, Lene Buhl; Danese, Silvio

    2014-01-01

    AIM: While collagenous colitis represents the most common form of the collagenous gastroenteritides, the collagenous entities affecting the proximal part of the gastrointestinal tract are much less recognized and possibly overlooked. The aim was to summarize the latest information through a syste...

  18. Proximal femoral fractures

    DEFF Research Database (Denmark)

    Palm, Henrik; Teixidor, Jordi

    2015-01-01

    searched the homepages of the national heath authorities and national orthopedic societies in West Europe and found 11 national or regional (in case of no national) guidelines including any type of proximal femoral fracture surgery. RESULTS: Pathway consensus is outspread (internal fixation for un...

  19. Proximate Analysis of Coal

    Science.gov (United States)

    Donahue, Craig J.; Rais, Elizabeth A.

    2009-01-01

    This lab experiment illustrates the use of thermogravimetric analysis (TGA) to perform proximate analysis on a series of coal samples of different rank. Peat and coke are also examined. A total of four exercises are described. These are dry exercises as students interpret previously recorded scans. The weight percent moisture, volatile matter,…

  20. Is ‘back to Vygotsky’ enough? the legacy of socio-historicocultural psychology Volverse a Vygotsky es suficiente? el legado de la psicología socio histórico cultural Voltar para Vygotsky é o suficiente? o legado da psicologia sócio-histórico-cultural

    Directory of Open Access Journals (Sweden)

    Mohamed Elhammoumi

    2010-12-01

    Full Text Available Is ‘back to Vygotsky’ enough? Vygotsky’s psychology has its roots in Marx’s writings. Thus, Marxism is indispensable to the study of Vygotsky’s theory. That is why, we assert in this paper that, back to Vygotsky is back to Marx and Marxism. Furthermore any attempt to modify Vygotsky’s uses of Marxism with some extraneous element is not only objectively anti-Vygotsky but also distortion of his theory. Vygotsky brought into prominence the dialectic movement of social totalities, within which a complex interaction takes place between forces of production, social relations of production, means of production, mode production, consciousness, alienation, and activity. In these complex interactions that human mental life is formed and shaped. Aware of these pitfalls, Vygotsky did not try to build a Marxist psychology that lies on the side of the economic determinism theory. Vygotsky’s efforts were directed, instead, to locating psychological aspects in Marx’s writings and making one of these aspects a new point of departure for examining the same totality with which Marx was concerned.Volver para Vygotsky es suficiente? La sicología de Vygotsky tiene sus raíces en los escritos de Marx. Así, el marxismo es indispensable para el estudio de la teoría de Vygotsky. Por eso, afirmamos en este trabajo que, al volver para Vygotsky también se vuelte para Marx y para el marxismo. Además, cualquier intento de modificar el uso que Vygotsky hizo de las ideas del marxismo con algún elemento raro no es sólo objetivamente anti-Vygotsky, pero también la distorción de su teoría. Vygotsky trajo en destaque el movimiento dialético de las totalidades sociales, dentro del cual una compleja interación ocurre entre las fuerzas de producción, relaciones sociales de producción, los medios de producción, modo de producción, consciencia, alienación y actividad. Y es en esas interacciones complejas que la vida mental humana es formada y moldada

  1. Promoting proximal formative assessment with relational discourse

    Science.gov (United States)

    Scherr, Rachel E.; Close, Hunter G.; McKagan, Sarah B.

    2012-02-01

    The practice of proximal formative assessment - the continual, responsive attention to students' developing understanding as it is expressed in real time - depends on students' sharing their ideas with instructors and on teachers' attending to them. Rogerian psychology presents an account of the conditions under which proximal formative assessment may be promoted or inhibited: (1) Normal classroom conditions, characterized by evaluation and attention to learning targets, may present threats to students' sense of their own competence and value, causing them to conceal their ideas and reducing the potential for proximal formative assessment. (2) In contrast, discourse patterns characterized by positive anticipation and attention to learner ideas increase the potential for proximal formative assessment and promote self-directed learning. We present an analysis methodology based on these principles and demonstrate its utility for understanding episodes of university physics instruction.

  2. Zone of proximal development (ZPD) as an ability to play in psychotherapy: a theory-building case study of very brief therapy.

    Science.gov (United States)

    Zonzi, Anna; Barkham, Michael; Hardy, Gillian E; Llewelyn, Susan P; Stiles, William B; Leiman, Mikael

    2014-12-01

    This theory-building case study examined the zone of proximal development (ZPD) in psychotherapy within the assimilation model. Theoretically, the ZPD is the segment of the continuum of therapeutic development within which assimilation of problematic experiences can take place. Work within a problem's current ZPD may be manifested as a Winnicottian ability to play, that is, an ability to adopt a flexible reflexive stance to the presenting problem and be involved in joint examination of possible alternatives. Play may be recognized in the client's receptivity to and creative use of the therapist's formulations of the presenting problems. A case was selected from a comparative clinical trial of two very brief psychotherapies for mild to moderate depression, the Two-Plus-One Project (Barkham, Shapiro, Hardy, & Rees, 1999, J. Consult. Clin. Psychol., 67, 201). Martha, a woman in her late forties, received two sessions of psychodynamic-interpersonal therapy 1 week apart and a follow-up ('plus one') session approximately 3 months later. Dialogical sequence analysis was used to analyse the transcripts of the three sessions. The analysis revealed Martha's problematic action pattern, which remained unchanged throughout the three sessions. Her ability to use and elaborate the therapist's formulations depended on the referential object that the therapist addressed; in particular, she seemed unable to play with the therapist's formulations of her more problematic experiences. The case helped elucidate how the ZPD is content dependent. Winnicott's conception of playing emphasizes the quality of client response as an indicator of this content sensitivity. Differing breadths of major problems' ZPD, manifested as differing abilities to play with therapists' formulations may explain why some clients improve in psychotherapy while some do not. Accessing very problematic content may be very difficult even though the client's ability to mentalize other material appears ordinary

  3. Development of the safety control framework for shield tunneling in close proximity to the operational subway tunnels: case studies in mainland China.

    Science.gov (United States)

    Li, Xinggao; Yuan, Dajun

    2016-01-01

    China's largest cities like Beijing and Shanghai have seen a sharp increase in subway network development as a result of the rapid urbanization in the last decade. The cities are still expanding their subway networks now, and many shield tunnels are being or will be constructed in close proximity to the existing operational subway tunnels. The execution plans for the new nearby shield tunnel construction calls for the development of a safety control framework-a set of control standards and best practices to help organizations manage the risks involved. Typical case studies and relevant key technical parameters are presented with a view to presenting the resulting safety control framework. The framework, created through collaboration among the relevant parties, addresses and manages the risks in a systematic way based on actual conditions of each tunnel crossing construction. The framework consists of six parts: (1) inspecting the operational subway tunnels; (2) deciding allowed movements of the existing tunnels and tracks; (3) simulating effects of the shield tunneling on the existing tunnels; (4) doing preparation work; (5) monitoring design and information management; and (6) measures and activation mechanism of the countermeasures. The six components are explained and demonstrated in detail. In the end, discussions made involve construction and post-construction settlement of the operational tunnel, application of the remedial grouting to rectify excessive settlements of the operational tunnel, and use of the innovative tool of the optical fiber measurement for tunnel movement monitoring. It is concluded that the construction movement of the tunnel can be controlled within 15 mm when the shield machine is <7 m in excavation diameter. The post-construction settlement of the tunnel buried in the very soft ground is much greater than its construction settlement, and last several years until reaching a final stable state. Two cases are outlined to demonstrate the

  4. Proximity friction reexamined

    International Nuclear Information System (INIS)

    Krappe, H.J.

    1989-01-01

    The contribution of inelastic excitations to radial and tangential friction form-factors in heavy-ion collisions is investigated in the frame-work of perturbation theory. The dependence of the form factors on the essential geometrical and level-density parameters of the scattering system is exhibited in a rather closed form. The conditions for the existence of time-local friction coefficients are discussed. Results are compared to form factors from other models, in particular the transfer-related proximity friction. For the radial friction coefficient the inelastic excitation mechanism seems to be the dominant contribution in peripheral collisions. (orig.)

  5. Proximal femoral fractures.

    Science.gov (United States)

    Webb, Lawrence X

    2002-01-01

    Fractures of the proximal femur include fractures of the head, neck, intertrochanteric, and subtrochanteric regions. Head fractures commonly accompany dislocations. Neck fractures and intertrochanteric fractures occur with greatest frequency in elderly patients with a low bone mineral density and are produced by low-energy mechanisms. Subtrochanteric fractures occur in a predominantly strong cortical osseous region which is exposed to large compressive stresses. Implants used to address these fractures must be able to accommodate significant loads while the fractures consolidate. Complications secondary to these injuries produce significant morbidity and include infection, nonunion, malunion, decubitus ulcers, fat emboli, deep venous thrombosis, pulmonary embolus, pneumonia, myocardial infarction, stroke, and death.

  6. Vygotsky e múltiplas representações: leituras convergentes para o ensino de ciências

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Laburú

    2013-04-01

    Full Text Available http://dx.doi.org/10.5007/2175-7941.2013v30n1p7 Este trabalho traz uma reflexão centrada no tema linguagem e pensamento de Vygotsky, com o objetivo de mostrar que pontos de vista do autor sobre o assunto se encontram subjacentes às argumentações que sustentam o referencial de multimodos e múltiplas representações. Há pouco mais de uma década em desenvolvimento, o programa de pesquisa de multimodos e múltiplas representações vem se mostrando progressivo, conclusão garantida, tanto pela abrangência internacional de suas pesquisas como pela amplitude no trato das questões envolvidas com a educação científica e matemática. Por ser a semiótica a teoria que ampara esse programa de pesquisa e a psicologia a que ampara os estudos vygotskianos, o que faz com que, quase sempre, estes últimos estejam ausentes nas referências do primeiro. Todavia, o referencial de multimodos e múltiplas representações faz afirmações que se revelam compatíveis com a posição de Vygotsky no que toca a indissociável interdependência entre linguagem e pensamento. Assim, com base nessa interdependência, o trabalho discute e aponta que o uso de variabilidade de linguagens, nas suas mais diversas representações, defendido pelo referencial multimodal e de múltiplas representações, é compatível e convergente com a leitura vygotskiana sobre o tema.

  7. Distributed Autonomous Control of Multiple Spacecraft During Close Proximity Operations

    National Research Council Canada - National Science Library

    McCamish, Shawn B

    2007-01-01

    This research contributes to multiple spacecraft control by developing an autonomous distributed control algorithm for close proximity operations of multiple spacecraft systems, including rendezvous...

  8. Echosonography with proximity sensors

    International Nuclear Information System (INIS)

    Thaisiam, W; Laithong, T; Meekhun, S; Chaiwathyothin, N; Thanlarp, P; Danworaphong, S

    2013-01-01

    We propose the use of a commercial ultrasonic proximity sensor kit for profiling an altitude-varying surface by employing echosonography. The proximity sensor kit, two identical transducers together with its dedicated operating circuit, is used as a profiler for the construction of an image. Ultrasonic pulses are emitted from one of the transducers and received by the other. The time duration between the pulses allows us to determine the traveling distance of each pulse. In the experiment, the circuit is used with the addition of two copper wires for directing the outgoing and incoming signals to an oscilloscope. The time of flight of ultrasonic pulses can thus be determined. Square grids of 5 × 5 cm 2 are made from fishing lines, forming pixels in the image. The grids are designed to hold the detection unit in place, about 30 cm above a flat surface. The surface to be imaged is constructed to be height varying and placed on the flat surface underneath the grids. Our result shows that an image of the profiled surface can be created by varying the location of the detection unit along the grid. We also investigate the deviation in relation to the time of flight of the ultrasonic pulse. Such an experiment should be valuable for conveying the concept of ultrasonic imaging to physical and medical science undergraduate students. Due to its simplicity, the setup could be made in any undergraduate laboratory relatively inexpensively and it requires no complex parts. The results illustrate the concept of echosonography. (paper)

  9. Proximity operations concept design study, task 6

    Science.gov (United States)

    Williams, A. N.

    1990-01-01

    The feasibility of using optical technology to perform the mission of the proximity operations communications subsystem on Space Station Freedom was determined. Proximity operations mission requirements are determined and the relationship to the overall operational environment of the space station is defined. From this information, the design requirements of the communication subsystem are derived. Based on these requirements, a preliminary design is developed and the feasibility of implementation determined. To support the Orbital Maneuvering Vehicle and National Space Transportation System, the optical system development is straightforward. The requirements on extra-vehicular activity are such as to allow large fields of uncertainty, thus exacerbating the acquisition problem; however, an approach is given that could mitigate this problem. In general, it is found that such a system could indeed perform the proximity operations mission requirement, with some development required to support extra-vehicular activity.

  10. PROXIMITY MANAGEMENT IN CRISIS CONDITIONS

    Directory of Open Access Journals (Sweden)

    Ion Dorin BUMBENECI

    2010-01-01

    Full Text Available The purpose of this study is to evaluate the level of assimilation for the terms "Proximity Management" and "Proximity Manager", both in the specialized literature and in practice. The study has two parts: the theoretical research of the two terms, and an evaluation of the use of Proximity management in 32 companies in Gorj, Romania. The object of the evaluation resides in 27 companies with less than 50 employees and 5 companies with more than 50 employees.

  11. Chi ha paura del relativismo? Peirce, Wittgenstein, Vygotski e le radici linguistiche della conoscenza (non della realtà.

    Directory of Open Access Journals (Sweden)

    Letizia Caronia

    2012-11-01

    Full Text Available Le derive decostruzioniste e antirealiste e la discutibile equivalenza tra relativismo e disimpegno scettico hanno necessariamente prodotto un richiamo al realismo e un ennesimo appello alla necessità di una fondazione ultima delle conoscenze, delle decisioni e delle pratiche. Stiamo gettando via il bambino insieme all’acqua sporca? Questo articolo argomenta la tesi dell’irritante ineluttabilità del costruttivismo. Attraverso un riordinamento delle categorie pertinenti e sulla scorta del pensiero di Peirce, Wittgenstein e Vygotsky, si sostiene che il costruttivismo a presuppone una ontologia realista; b afferma che la realtà sia osservabile, rappresentabile, descrivibile; c implica una definizione di verità come corrispondenza ma nega che sia possibile individuare quell’ “una e una sola” descrizione della realtà che corrisponderebbe alla realtà in modi indipendenti dal linguaggio. Nelle sezioni conclusive si discutono le implicazioni del costruttivismo realista. In particolare ci si propone di dimostrare l’ineludibile e radicale appello alla responsabilità proprio – malgrado le apparenze – di uno dei corollati del costruttivismo: la relatività concettuale e la connessa questione della relatività epistemica.

  12. The developmental spectrum of proximal radioulnar synostosis

    Energy Technology Data Exchange (ETDEWEB)

    Elliott, Alison M. [University of Manitoba, Winnipeg Regional Health Association Program of Genetics and Metabolism, Winnipeg, MB (Canada); University of Manitoba, Department of Paediatrics and Child Health, Winnipeg, MB (Canada); University of Manitoba, Department of Biochemistry and Medical Genetics, Winnipeg, MB (Canada); University of Manitoba, WRHA Program of Genetics and Metabolism, Departments of Paediatrics and Child Health, Biochemistry and Medical Genetics, Winnipeg, MB (Canada); Kibria, Lisa [University of Manitoba, Department of School of Medical Rehabilitation, Winnipeg, MB (Canada); Reed, Martin H. [University of Manitoba, Department of Paediatrics and Child Health, Winnipeg, MB (Canada); University of Manitoba, Department of Biochemistry and Medical Genetics, Winnipeg, MB (Canada); University of Manitoba, Department of Diagnostic Imaging, Winnipeg, MB (Canada)

    2010-01-15

    Proximal radioulnar synostosis is a rare upper limb malformation. The elbow is first identifiable at 35 days (after conception), at which stage the cartilaginous anlagen of the humerus, radius and ulna are continuous. Subsequently, longitudinal segmentation produces separation of the distal radius and ulna. However, temporarily, the proximal ends are united and continue to share a common perichondrium. We investigated the hypothesis that posterior congenital dislocation of the radial head and proximal radioulnar fusion are different clinical manifestations of the same primary developmental abnormality. Records were searched for ''proximal radioulnar fusion/posterior radial head dislocation'' in patients followed at the local Children's Hospital and Rehabilitation Centre for Children. Relevant radiographic, demographic and clinical data were recorded. Ethics approval was obtained through the University Research Ethics Board. In total, 28 patients met the inclusion criteria. The majority of patients (16) had bilateral involvement; eight with posterior dislocation of the radial head only; five had posterior radial head dislocation with radioulnar fusion and two had radioulnar fusion without dislocation. One patient had bilateral proximal radioulnar fusion and posterior dislocation of the left radial head. Nine patients had only left-sided involvement, and three had only right-sided involvement.The degree of proximal fusion varied, with some patients showing 'complete' proximal fusion and others showing fusion that occurred slightly distal to the radial head: 'partially separated.' Associated disorders in our cohort included Poland syndrome (two patients), Cornelia de Lange syndrome, chromosome anomalies (including tetrasomy X) and Cenani Lenz syndactyly. The suggestion of a developmental relationship between posterior dislocation of the radial head and proximal radioulnar fusion is supported by the fact that both anomalies

  13. ProxImaL: efficient image optimization using proximal algorithms

    KAUST Repository

    Heide, Felix; Diamond, Steven; Nieß ner, Matthias; Ragan-Kelley, Jonathan; Heidrich, Wolfgang; Wetzstein, Gordon

    2016-01-01

    domain-specific language and compiler for image optimization problems that makes it easy to experiment with different problem formulations and algorithm choices. The language uses proximal operators as the fundamental building blocks of a variety

  14. A proximal point algorithm with generalized proximal distances to BEPs

    OpenAIRE

    Bento, G. C.; Neto, J. X. Cruz; Lopes, J. O.; Soares Jr, P. A.; Soubeyran, A.

    2014-01-01

    We consider a bilevel problem involving two monotone equilibrium bifunctions and we show that this problem can be solved by a proximal point method with generalized proximal distances. We propose a framework for the convergence analysis of the sequences generated by the algorithm. This class of problems is very interesting because it covers mathematical programs and optimization problems under equilibrium constraints. As an application, we consider the problem of the stability and change dyna...

  15. Fractures of the proximal humerus

    DEFF Research Database (Denmark)

    Brorson, Stig

    2013-01-01

    Fractures of the proximal humerus have been diagnosed and managed since the earliest known surgical texts. For more than four millennia the preferred treatment was forceful traction, closed reduction, and immobilization with linen soaked in combinations of oil, honey, alum, wine, or cerate......, classification of proximal humeral fractures remains a challenge for the conduct, reporting, and interpretation of clinical trials. The evidence for the benefits of surgery in complex fractures of the proximal humerus is weak. In three systematic reviews I studied the outcome after locking plate osteosynthesis...

  16. Development of a Scintillation Proximity Assay (SPA) Based, High Throughput Screening Feasible Method for the Identification of PDE12 Activity Modulators.

    Science.gov (United States)

    Mang, Samuel; Bucher, Hannes; Nickolaus, Peter

    2016-01-01

    The scintillation proximity assay (SPA) technology has been widely used to establish high throughput screens (HTS) for a range of targets in the pharmaceutical industry. PDE12 (aka. 2'- phosphodiesterase) has been published to participate in the degradation of oligoadenylates that are involved in the establishment of an antiviral state via the activation of ribonuclease L (RNAse-L). Degradation of oligoadenylates by PDE12 terminates these antiviral activities, leading to decreased resistance of cells for a variety of viral pathogens. Therefore inhibitors of PDE12 are discussed as antiviral therapy. Here we describe the use of the yttrium silicate SPA bead technology to assess inhibitory activity of compounds against PDE12 in a homogeneous, robust HTS feasible assay using tritiated adenosine-P-adenylate ([3H]ApA) as substrate. We found that the used [3H]ApA educt, was not able to bind to SPA beads, whereas the product [3H]AMP, as known before, was able to bind to SPA beads. This enables the measurement of PDE12 activity on [3H]ApA as a substrate using a wallac microbeta counter. This method describes a robust and high throughput capable format in terms of specificity, commonly used compound solvents, ease of detection and assay matrices. The method could facilitate the search for PDE12 inhibitors as antiviral compounds.

  17. Integrating Science and Mathematics Curricula Using Computer Mediated Communications: A Vygotskian Perspective.

    Science.gov (United States)

    Charnitski, Christina Wotell; Harvey, Francis A.

    This paper presents the theories of L.S. Vygotsky as a conceptual framework for implementing instruction that supports concept development and promotes higher level thinking skills in students. Three major components (i.e., language, scientific and spontaneous concepts, and the zone of proximal development) of Vygotsky's socio-cultural-historical…

  18. Análisis de la teoría de Vygotsky para la reconstrucción de la inteligencia social

    OpenAIRE

    Ledesma-Ayora, Marco

    2014-01-01

    [SP]Es extraño escribir sobre Vygotsky y al mismo tiempo complejo, los docentes que han leído durante años sobre él, se han convertido ahora en grandes mediadores del aprendizaje y desarrollo humano, coexistiendo un fundamento en la actualidad para muchas áreas educativas prácticas y su transmisión cultural a través de la Pedagogía, Desarrollo del pensamiento, Psicolingüística, Lenguaje, Psicología, Neurolingüística, Psicopedagogía, Neurociencias y otras por aplicarse, valiéndose de la episte...

  19. Preliminary study on leadership proximity

    Directory of Open Access Journals (Sweden)

    Ghinea Valentina Mihaela

    2017-07-01

    Full Text Available In general, it is agreed that effective leadership requires a certain degree of proximity, either physical or mental, which enables leaders to maintain control over their followers and communicate their vision. Although we agree with the leadership proximity principles which states that leaders are able to efficiently serve only those people with whom they interact frequently, in this article we focus instead on the disadvantages of being too close and the way in which close proximity can actually hurt the effectiveness of leadership. The main effects that we discuss regard the way in which proximity and familiarity allow followers to see the weaknesses and faults of the leader much more easily and thus diminish the leader’s heroic aura, and the emotional bias that results from a leader being too familiar with his followers which will impede the process of rational decision making. As a result, we argue that there exists a functional proximity which allows the leader the necessary space in which to perform effective identity work and to hide the backstage aspects of leadership, while also allowing him an emotional buffer zone which will enable him to maintain the ability to see clearly and make rational decisions.

  20. Population Exposure Estimates in Proximity to Nuclear Power Plants, Locations

    Data.gov (United States)

    National Aeronautics and Space Administration — The Population Exposure Estimates in Proximity to Nuclear Power Plants, Locations data set combines information from a global data set developed by Declan Butler of...

  1. The dynamics of general developmental mechanisms : From Piaget and Vygotsky to dynamic systems models

    NARCIS (Netherlands)

    van Geert, P

    Dynamic systems theory conceives of development as a self-organizational process. Both complexity and order emerge as a product of elementary principles of interaction between components involved in the developmental process. This article presents a dynamic systems model based on a general dual

  2. Multimodal Modeling Activities with Special Needs Students in an Informal Learning Context: Vygotsky Revisited

    Science.gov (United States)

    Kim, Mi Song

    2017-01-01

    In light of the challenges facing science educators and special education teachers in Singapore, this study entails design-based research to develop participatory learning environments. Drawing upon Vygotskian perspectives, this case study was situated in an informal workshop around the theme of "day and night" working for Special Needs…

  3. Proximity of Practice

    DEFF Research Database (Denmark)

    Ren, Carina Bregnholm; Gyimóthy, Szilvia; Jensen, Martin Trandberg

    2014-01-01

    There is a widespread acknowledgement among European policy-makers that higher education may potentially contribute to enhancing competitiveness of tourism. This has led to a sheer explosion of specific measures encouraging knowledge transfer with the private sector. Despite the importance...... of knowledge flow processes, the role of universities and students has been little researched or linked to the understanding of innovation defectiveness in tourism. Followed by a critical review of knowledge transfer and learning processes in generic development and tourism literature, the chapter presents...... an illustrative case from an innovation course on a Danish Master program in tourism. The case describes and discusses challenges in working with, creating and implementing innovation through student-practitioner collaboration. It is argued that successful innovation is not solely, as previously argued...

  4. Parents' management of the development of their children with disabilities

    DEFF Research Database (Denmark)

    Dammeyer, Jesper Herup

    2010-01-01

     Being the parent of a disabled child is not easy, it is experienced as a situation marked by stress, crises and grief. As Vygotsky described eighty years ago, the development of children with disabilities and the culture do not fit as they do for non-disabled children. The development of a child...

  5. VIGOTSKI, DESARROLLO INFANTIL Y APORTES PARA EL AULA COSTARRICENSE VYGOTSKY, (CHILD DEVELOPMENT AND CONTRIBUTIONS TO THE COSTARRICAN CLASSROOM)

    OpenAIRE

    Antoni Maurizia D’

    2009-01-01

    Resumen:En el presente ensayo es producto de un curso sobre Vigotski con la profesora Wanda Rodríguez Arocho en el marco del Congreso sobre Vigotski y Freire de 2007, donde se buscó trabajar dos conceptos vigotskianos, zona de desarrollo próximo y situación social de desarrollo, sirviéndome de mi experiencia personal, de un lado para denunciar y de otro para proponer. Uno de estos ámbitos de experiencia nace del Módulo de Psicología Educativa II, de la Escuela de Psicología de la Universidad ...

  6. Proximal sensing for soil carbon accounting

    Science.gov (United States)

    England, Jacqueline R.; Viscarra Rossel, Raphael A.

    2018-05-01

    Maintaining or increasing soil organic carbon (C) is vital for securing food production and for mitigating greenhouse gas (GHG) emissions, climate change, and land degradation. Some land management practices in cropping, grazing, horticultural, and mixed farming systems can be used to increase organic C in soil, but to assess their effectiveness, we need accurate and cost-efficient methods for measuring and monitoring the change. To determine the stock of organic C in soil, one requires measurements of soil organic C concentration, bulk density, and gravel content, but using conventional laboratory-based analytical methods is expensive. Our aim here is to review the current state of proximal sensing for the development of new soil C accounting methods for emissions reporting and in emissions reduction schemes. We evaluated sensing techniques in terms of their rapidity, cost, accuracy, safety, readiness, and their state of development. The most suitable method for measuring soil organic C concentrations appears to be visible-near-infrared (vis-NIR) spectroscopy and, for bulk density, active gamma-ray attenuation. Sensors for measuring gravel have not been developed, but an interim solution with rapid wet sieving and automated measurement appears useful. Field-deployable, multi-sensor systems are needed for cost-efficient soil C accounting. Proximal sensing can be used for soil organic C accounting, but the methods need to be standardized and procedural guidelines need to be developed to ensure proficient measurement and accurate reporting and verification. These are particularly important if the schemes use financial incentives for landholders to adopt management practices to sequester soil organic C. We list and discuss requirements for developing new soil C accounting methods based on proximal sensing, including requirements for recording, verification, and auditing.

  7. ProxImaL: efficient image optimization using proximal algorithms

    KAUST Repository

    Heide, Felix

    2016-07-11

    Computational photography systems are becoming increasingly diverse, while computational resources-for example on mobile platforms-are rapidly increasing. As diverse as these camera systems may be, slightly different variants of the underlying image processing tasks, such as demosaicking, deconvolution, denoising, inpainting, image fusion, and alignment, are shared between all of these systems. Formal optimization methods have recently been demonstrated to achieve state-of-the-art quality for many of these applications. Unfortunately, different combinations of natural image priors and optimization algorithms may be optimal for different problems, and implementing and testing each combination is currently a time-consuming and error-prone process. ProxImaL is a domain-specific language and compiler for image optimization problems that makes it easy to experiment with different problem formulations and algorithm choices. The language uses proximal operators as the fundamental building blocks of a variety of linear and nonlinear image formation models and cost functions, advanced image priors, and noise models. The compiler intelligently chooses the best way to translate a problem formulation and choice of optimization algorithm into an efficient solver implementation. In applications to the image processing pipeline, deconvolution in the presence of Poisson-distributed shot noise, and burst denoising, we show that a few lines of ProxImaL code can generate highly efficient solvers that achieve state-of-the-art results. We also show applications to the nonlinear and nonconvex problem of phase retrieval.

  8. Theoretical and Methodological Basis of Inclusive Education in the Researches of Russian Scientists in the First Quarter of 20th Century (P. P. Blonsky, L. S. Vygotsky, v. P. Kaschenko, S. T. Shatsky)

    Science.gov (United States)

    Akhmetova, Daniya Z.; Chelnokova, Tatyana A.; Morozova, Ilona G.

    2017-01-01

    Article is devoted to the scientific heritage of educators and psychologists of Russia in the first quarter of the twentieth century. The aim of the research is the identification of the most significant ideas of P. P. Blonsky, L. S. Vygotsky, V. P. Kacshenko, S. T Shatsky which based the theoretical and methodological basis of inclusive…

  9. Electromagnetic properties of proximity systems

    Science.gov (United States)

    Kresin, Vladimir Z.

    1985-07-01

    Magnetic screening in the proximity system Sα-Mβ, where Mβ is a normal metal N, semiconductor (semimetal), or a superconductor, is studied. Main attention is paid to the low-temperature region where nonlocality plays an important role. The thermodynamic Green's-function method is employed in order to describe the behavior of the proximity system in an external field. The temperature and thickness dependences of the penetration depth λ are obtained. The dependence λ(T) differs in a striking way from the dependence in usual superconductors. The strong-coupling effect is taken into account. A special case of screening in a superconducting film backed by a size-quantizing semimetal film is considered. The results obtained are in good agreement with experimental data.

  10. Electromagnetic properties of proximity systems

    International Nuclear Information System (INIS)

    Kresin, V.Z.

    1985-01-01

    Magnetic screening in the proximity system S/sub α/-M/sub β/, where M/sub β/ is a normal metal N, semiconductor (semimetal), or a superconductor, is studied. Main attention is paid to the low-temperature region where nonlocality plays an important role. The thermodynamic Green's-function method is employed in order to describe the behavior of the proximity system in an external field. The temperature and thickness dependences of the penetration depth lambda are obtained. The dependence lambda(T) differs in a striking way from the dependence in usual superconductors. The strong-coupling effect is taken into account. A special case of screening in a superconducting film backed by a size-quantizing semimetal film is considered. The results obtained are in good agreement with experimental data

  11. Proximity effect at Millikelvin temperatures

    International Nuclear Information System (INIS)

    Mota, A.C.

    1986-01-01

    Proximity effects have been studied extensively for the past 25 years. Typically, they are in films several thousand angstroms thick at temperatures not so far below T/sub CNS/, the transition temperature of the NS system. Interesting is, however, the proximity effect at temperatures much lower than T/sub CNS/. In this case, the Cooper-pair amplitudes are not small and very long pair penetration lengths into the normal metal can be expected. Thus, we have observed pair penetration lengths. For these investigations very suitable specimens are commercial wires of one filament of NbTi or Nb embedded in a copper matrix. The reasons are the high transmission coefficient at the interface between the copper and the superconductor and the fact that the copper in these commercial wires is rather clean with electron free paths between 5 to 10 μm long. In this paper, the magnetic properties of thick proximity systems in the range of temperatures between T/sub CNS/ and 5 x 10/sup -4/ T/sub CNS/ in both low and high magnetic fields are discussed

  12. Phonon structure in proximity tunnel junctions

    International Nuclear Information System (INIS)

    Zarate, H.G.; Carbotte, J.P.

    1985-01-01

    We have iterated to convergence, for the first time, a set of four coupled real axis Eliashberg equations for the superconducting gap and renormalization functions on each side of a proximity sandwich. We find that the phenomenological procedures developed to extract the size of the normal side electron-phonon interaction from tunneling data are often reasonable but may in some cases need modifications. In all the cases considered the superconducting phonon structure reflected on the normal side, as well as other structures, shows considerable agreement with experiment as to size, shape, and variation with barrier transmission coefficient. Finally, we study the effects of depairing on these structures

  13. Sociocultural Theory and its Role in the Development of Language Pedagogy

    Directory of Open Access Journals (Sweden)

    Abdul Hameed Panhwar

    2016-12-01

    Full Text Available This paper reviews the literature on Vygotskian theory of Socio-cultural learning and constructivist approach to teaching and learning and attempts to relate the socio-cultural theory to constructivism. The purpose of the paper is to investigate the ways socio-cultural theory helps to develop language pedagogies. Critical analysis of the literature on the socio-cultural theory suggests that the theory has potential for forming new context-oriented language teaching-learning pedagogies which can help teachers in maximising the effectiveness of their teaching and their student’s learning. The review further suggests that the language pedagogies and activities developed from the sociocultural theory of Vygotsky may not only improve students’ language skills, but it also has potential to develop students’ cognition. Since theory promotes more and more communication of students with each other through scaffolding, that is, the Zone of Proximal development (ZPD in Vygotsky’s language. Thus, the theory directly points towards the promotion of student-centred learning by establishing learner autonomy. Keywords: socio-cultural theory, language, constructivism, pedagogies, students

  14. Children’s proximal societal conditions

    DEFF Research Database (Denmark)

    Stanek, Anja Hvidtfeldt

    or the children’s everyday life, but something that is represented through societal structures and actual persons participating (in political ways) within the institutional settings, in ways that has meaning to children’s possibilities to participate, learn and develop. Understanding school or daycare as (part of......) the children’s proximal societal conditions for development and learning, means for instance that considerations about an inclusive agenda in a (Danish) welfare state with well-developed school- and daycare system, are no longer simply thoughts about the school having space for as many pupils as possible...... (schools for all). Such thoughts can or should be supplemented by reflections about which version of ‘the societal’ we wish to present our children with, and which version of ‘the societal’ we wish to set up as the condition for children’s participation and development. These questions require an ethical...

  15. Equilibrium properties of proximity effect

    International Nuclear Information System (INIS)

    Esteve, D.; Pothier, H.; Gueron, S.; Birge, N.O.; Devoret, M.

    1996-01-01

    The proximity effect in diffusive normal-superconducting (NS) nano-structures is described by the Usadel equations for the electron pair correlations. We show that these equations obey a variational principle with a potential which generalizes the Ginzburg-Landau energy functional. We discuss simple examples of NS circuits using this formalism. In order to test the theoretical predictions of the Usadel equations, we have measured the density of states as a function of energy on a long N wire in contact with a S wire at one end, at different distances from the NS interface. (authors)

  16. Equilibrium properties of proximity effect

    Energy Technology Data Exchange (ETDEWEB)

    Esteve, D.; Pothier, H.; Gueron, S.; Birge, N.O.; Devoret, M.

    1996-12-31

    The proximity effect in diffusive normal-superconducting (NS) nano-structures is described by the Usadel equations for the electron pair correlations. We show that these equations obey a variational principle with a potential which generalizes the Ginzburg-Landau energy functional. We discuss simple examples of NS circuits using this formalism. In order to test the theoretical predictions of the Usadel equations, we have measured the density of states as a function of energy on a long N wire in contact with a S wire at one end, at different distances from the NS interface. (authors). 12 refs.

  17. Vygotsky's theories of play, imagination and creativity in current practice: Gunilla Lindqvist's “creative pedagogy of play” in U. S. kindergartens and Swedish Reggio-Emilia inspired preschools

    Directory of Open Access Journals (Sweden)

    Monica Nilsson

    2014-05-01

    Full Text Available http://dx.doi.org/10.5007/2175-795X.2014v32n3p919 The ideal of modern western childhood, with its emphasis on the innocence and malleability of children, has combined with various social conditions to promote adult's direction of children's play towards adult-determined developmental goals, and adult's protection of children's play from adults.However, new forms of play, in which adults actively enter into the fantasy play of young children as a means of promoting the development and quality of life of both adults and children, have recently emerged in several countries (Sweden, Serbia (the former Yugoslavia, Finland, Japan and the United States. In this paper we discuss the theoretical support for this new form of activity:we argue thatGunilla Lindqvist's reinterpretation ofVygotsky's theory of play, with its emphasis on the creative quality of play, is unique amongst contemporary Western European and American theories of play. And we describe a series of formative interventions that are both instantiations of this new form of activity and an investigation of its theoretical support, which are being conducted in theUnited States and Sweden. Researchers at the Laboratory of Comparative Human Cognition at the University of California, SanDiego have implemented and studied Lindqvist's creative pedagogy of play in U.S. early childhood public school classrooms. Over the past year the central component of this pedagogy, playworlds, has been introduced and studied in three Swedish Reggio-Emilia inspired preschools. In conclusion, some of the findings from these research projects are presented.

  18. Henri Wallon's Theory of Early Child Development: The Role of Emotions.

    Science.gov (United States)

    Van der Veer, Rene

    1996-01-01

    Discusses the stage theory of early child development of French theorist Henri Wallon. Describes Wallon's efforts (in contrast to contemporary Piaget) to describe emotional development and the role emotions play in establishing the child-caregiver bond. Argues that Wallon's theory is unique in its focus, influenced theorists such as Vygotsky, and…

  19. The Internalization Theory of Emotions: A Cultural Historical Approach to the Development of Emotions

    Science.gov (United States)

    Holodynski, Manfred

    2013-01-01

    Starting with an overview of theoretical approaches to emotion from an activity-oriented stance, this article applies Vygotsky's three general principles of development, sign mediation, and internalization to the development of emotional expressions as a culturally evolved sign system. The possible twofold function of expression signs as a means…

  20. Consciousness, Social Heredity, and Development: The Evolutionary Thought of James Mark Baldwin

    Science.gov (United States)

    Wozniak, Robert H.

    2009-01-01

    James Mark Baldwin is one of the most important and least known early American scientific psychologists. Drawing inspiration from Charles Darwin and other evolutionists of the period, Baldwin developed a biosocial theory of psychological development that influenced both Jean Piaget and Lev S. Vygotsky; and he proposed a mechanism relating learned…

  1. Realities of proximity facility siting

    International Nuclear Information System (INIS)

    DeMott, D.L.

    1981-01-01

    Numerous commercial nuclear power plant sites have 2 to 3 reactors located together, and a group of Facilities with capabilities for fuel fabrication, a nuclear reactor, a storage area for spent fuel, and a maintenance area for contaminated equipment and radioactive waste storage are being designed and constructed in the US. The proximity of these facilities to each other provides that the ordinary flow of materials remain within a limited area. Interactions between the various facilities include shared resources such as communication, fire protection, security, medical services, transportation, water, electrical, personnel, emergency planning, transport of hazardous material between facilities, and common safety and radiological requirements between facilities. This paper will explore the advantages and disadvantages of multiple facilities at one site. Problem areas are identified, and recommendations for planning and coordination are discussed

  2. comparative proximate composition and antioxidant vitamins

    African Journals Online (AJOL)

    DR. AMINU

    Keywords: Comparative, proximate composition, antioxidant vitamins, honey. INTRODUCTION ... solution of inverted sugars and complex mixture of other saccharides ... enzymatic browning in apple slices and grape juice. (Khan, 1985).

  3. Proximate, Mineral and Phytochemical Composition of Dioscorea ...

    African Journals Online (AJOL)

    ADOWIE PERE

    Keywords: Dioscorea dumetorum, proximate composition, mineral analysis, phytochemical screening ... were analyzed using atomic absorption ... determined using a Hack Dr/200 Spectrophotometer. ... Lead Acetate. +. +. + .... cosmetics.

  4. Proximate composition and antinutrient content of pumpkin ...

    African Journals Online (AJOL)

    Proximate composition and antinutrient content of pumpkin ( Cucurbita pepo ) and sorghum ( Sorghum bicolor ) flour blends fermented with Lactobacillus plantarum , Aspergillus niger and Bacillus subtilis.

  5. Symmetry-based reciprocity: evolutionary constraints on a proximate mechanism.

    Science.gov (United States)

    Campennì, Marco; Schino, Gabriele

    2016-01-01

    Background. While the evolution of reciprocal cooperation has attracted an enormous attention, the proximate mechanisms underlying the ability of animals to cooperate reciprocally are comparatively neglected. Symmetry-based reciprocity is a hypothetical proximate mechanism that has been suggested to be widespread among cognitively unsophisticated animals. Methods. We developed two agent-based models of symmetry-based reciprocity (one relying on an arbitrary tag and the other on interindividual proximity) and tested their ability both to reproduce significant emergent features of cooperation in group living animals and to promote the evolution of cooperation. Results. Populations formed by agents adopting symmetry-based reciprocity showed differentiated "social relationships" and a positive correlation between cooperation given and received: two common aspects of animal cooperation. However, when reproduction and selection across multiple generations were added to the models, agents adopting symmetry-based reciprocity were outcompeted by selfish agents that never cooperated. Discussion. In order to evolve, hypothetical proximate mechanisms must be able to stand competition from alternative strategies. While the results of our simulations require confirmation using analytical methods, we provisionally suggest symmetry-based reciprocity is to be abandoned as a possible proximate mechanism underlying the ability of animals to reciprocate cooperative interactions.

  6. Quantifying social contacts in a household setting of rural Kenya using wearable proximity sensors

    OpenAIRE

    Kiti, Moses C.; Tizzoni, Michele; Kinyanjui, Timothy M.; Koech, Dorothy C.; Munywoki, Patrick K.; Meriac, Milosch; Cappa, Luca; Panisson, André; Barrat, Alain; Cattuto, Ciro; Nokes, D. James

    2016-01-01

    Close proximity interactions between individuals influence how infections spread. Quantifying close contacts in developing world settings, where such data is sparse yet disease burden is high, can provide insights into the design of intervention strategies such as vaccination. Recent technological advances have enabled collection of time-resolved face-to-face human contact data using radio frequency proximity sensors. The acceptability and practicalities of using proximity devices within the ...

  7. The Role of Make-Believe Play in the Development of Executive Function: Status of Research and Future Directions

    Science.gov (United States)

    Berk, Laura E.; Meyers, Adena B.

    2013-01-01

    The authors discuss the association between make-believe play and the development of executive-function (EF) skills in young children. Some forty years ago, Lev S. Vygotsky first proposed that make-believe fosters the development of symbolic thought and self-regulation. Since then, a small body of research has produced evidence of an association…

  8. Socio-Cultural Theories of Cognitive Development: Implications for Teaching Theory in the Visual Arts.

    Science.gov (United States)

    Fielding, Rob

    1989-01-01

    Explicates the socio-cultural developmental theories of Vygotsky and Feuerstein which advocate teacher mediated learning in order to stimulate and accelerate development. Implications for art education include the need for the teacher to become involved in the enculturation of the child into the thinking processes and conceptual organization of…

  9. Influences of Technology-Related Playful Activity and Thought on Moral Development

    Science.gov (United States)

    Bergen, Doris; Davis, Darrel

    2011-01-01

    Many early developmental theorists such as Freud, Erikson, Piaget, and Vygotsky suggested that play--which the authors of this article define as both playful activity and playful thought--had the power to influence the moral emotions, behaviors, and reasoning of children. More recent researchers have also found evidence of moral development in…

  10. Superconducting proximity effect in mesoscopic superconductor/normal-metal junctions

    CERN Document Server

    Takayanagi, H; Toyoda, E

    1999-01-01

    The superconducting proximity effect is discussed in mesoscopic superconductor/normal-metal junctions. The newly-developed theory shows long-range phase-coherent effect which explaines early experimental results of giant magnetoresistance oscillations in an Andreev interferometer. The theory also shows that the proximity correction to the conductance (PCC) has a reentrant behavior as a function of energy. The reentrant behavior is systematically studied in a gated superconductor-semiconductor junction. A negative PCC is observed in the case of a weak coupling between the normal metal and the external reservoir. Phase coherent ac effect is also observed when rf is irradiated to the junction.

  11. Transverse and Longitudinal proximity effect

    Science.gov (United States)

    Jalan, Pryianka; Chand, Hum; Srianand, Raghunathan

    2018-04-01

    With close pairs (˜1.5arcmin) of quasars (QSOs), absorption in the spectra of a background quasar in the vicinity of a foreground quasar can be used to study the environment of the latter quasar at kpc-Mpc scales. For this we used a sample of 205 quasar pairs from the Sloan Digital Sky-Survey Data Release 12 (SDSS DR12) in the redshift range of 2.5 to 3.5 by studying their H I Ly-α absorption. We study the environment of QSOs both in the longitudinal as well as in the transverse direction by carrying out a statistical comparison of the Ly-α absorption lines in the quasar vicinity to that of the absorption lines caused by the inter-galactic medium (IGM). This comparison was done with IGM, matched in absorption redshift and signal-to-noise ratio (SNR) to that of the proximity region. In contrast to the measurements along the line-of-sight, the regions transverse to the quasars exhibit enhanced H I Ly-α absorption. This discrepancy can either be interpreted as due to an anisotropic emission from the quasars or as a consequence of their finite lifetime.

  12. Effect of smoking and sun drying on proximate composition of ...

    African Journals Online (AJOL)

    Effect of smoking and sun drying on proximate composition of Diplotaxodon fish species (Ndunduma) from lake Malawi, Malawi. ... African Journal of Food, Agriculture, Nutrition and Development ... The fish were washed then weighed and thereafter, smoked in a traditional smoking kiln and sun dried on reed mats.

  13. Comparative physico-chemical and proximate analysis of oils of ...

    African Journals Online (AJOL)

    In rural areas of developing countries like Burkina Faso, nutritive elements are mainly composed of vegetable source. Shea nut, seeds of Sesamum indicum, Cucumis melo and Cucurbita pepo, four species widely consumed were studied. The proximate parameters: moisture, proteins and fat were analysed. Saponification ...

  14. Radiation tolerant design - theory and practice for proximity sensing

    International Nuclear Information System (INIS)

    Sharp, R.E.; Pater, S.L.; Cook, J.

    1999-01-01

    This paper provides a description of the radiation tolerant design process used to develop a range of proximity detectors with guaranteed total dose lifetime. It also describes some of the applications in which the detectors are being used and the benefits gained by plant operators. (authors)

  15. Proximal Participation: A Pathway into Work

    Science.gov (United States)

    Chan, Selena

    2013-01-01

    In a longitudinal case study of apprentices, the term proximal participation was coined to describe the entry process of young people, with unclear career destinations, into the trade of baking. This article unravels the significance of proximal participation in the decision-making processes of young people who enter a trade through initial…

  16. Bimalleolar ankle fracture with proximal fibular fracture

    NARCIS (Netherlands)

    Colenbrander, R. J.; Struijs, P. A. A.; Ultee, J. M.

    2005-01-01

    A 56-year-old female patient suffered a bimalleolar ankle fracture with an additional proximal fibular fracture. This is an unusual fracture type, seldom reported in literature. It was operatively treated by open reduction and internal fixation of the lateral malleolar fracture. The proximal fibular

  17. Sequential Proximal Tibial Stress Fractures associated with Prolonged usage of Methotrexate and Corticosteroids: A Case Report

    Directory of Open Access Journals (Sweden)

    Tan TJL

    2015-11-01

    Full Text Available Stress fractures of the proximal tibia metaphysis are rare in the elderly. We present a case of a 65-year old male who developed sequential proximal tibia stress fractures associated with prolonged usage of methotrexate and prednisolone within a span of 18 months. Magnetic Resonance Imaging revealed an incomplete stress fracture involving the medial proximal tibial region. The patient was treated with stemmed total knee arthroplasty (TKA bilaterally. Stress fractures should be considered in patients with atypical knee pain who have a history of methotrexate and prednisolone usage. TKA is an effective treatment in stress fractures of the proximal tibia.

  18. Modular endoprosthetic replacement for metastatic tumours of the proximal femur

    Directory of Open Access Journals (Sweden)

    Carter Simon R

    2008-11-01

    Full Text Available Abstract Background and aims Endoprosthetic replacements of the proximal femur are commonly required to treat destructive metastases with either impending or actual pathological fractures at this site. Modular prostheses provide an off the shelf availability and can be adapted to most reconstructive situations for proximal femoral replacements. The aim of this study was to assess the clinical and functional outcomes following modular tumour prosthesis reconstruction of the proximal femur in 100 consecutive patients with metastatic tumours and to compare them with the published results of patients with modular and custom made endoprosthetic replacements. Methods 100 consecutive patients who underwent modular tumour prosthetic reconstruction of the proximal femur for metastases using the METS system from 2001 to 2007 were studied. The patient, tumour and treatment factors in relation to overall survival, local control, implant survival and complications were analysed. Functional scores were obtained from surviving patients. Results and conclusion There were 45 male and 55 female patients. The mean age was 60.2 years. The indications were metastases. Seventy five patients presented with pathological fracture or with failed fixation and 25 patients were at a high risk of developing a fracture. The mean follow up was 15.9 months [range 0–77]. Three patients died within 2 weeks following surgery. 69 patients have died and 31 are alive. Of the 69 patients who were dead 68 did not need revision surgery indicating that the implant provided single definitive treatment which outlived the patient. There were three dislocations (2/5 with THR and 1/95 with unipolar femoral heads. 6 patients had deep infections. The estimated five year implant survival (Kaplan-Meier analysis was 83.1% with revision as end point. The mean TESS score was 64% (54%–82%. We conclude that METS modular tumour prosthesis for proximal femur provides versatility; low implant related

  19. A conclusão da educação superior por cegos e a psicologia de Vygotski: a ponta do iceberg

    Directory of Open Access Journals (Sweden)

    Bento Selau

    2017-02-01

    Full Text Available http://dx.doi.org/10.5007/2175-795X.2016v34n3p861 Este trabalho objetiva apresentar os fatores relacionados à conclusão da educação superior, por parte de um grupo de estudantes cegos, a partir de seus próprios pontos de vista. Realizaram-se estudos de casos com nove sujeitos, sendo os dados coletados por meio de entrevistas narrativas e análise documental e submetidos a um processo de análise textual discursiva. O referencial que embasou a pesquisa foi o da Psicologia Histórico-Cultural de Vygotski. Os achados apontam fatores que dificultaram a conclusão do ensino superior – como o processo de seleção, que ignora as necessidades dos cegos; a falta de preparo das instituições para atender os deficientes; os preconceitos de docentes. Ao mesmo tempo, indicam fatores que favoreceram essa conclusão – como o auxílio aos cegos por parte de docentes e familiares, a tomada de consciência sobre a importância da formação universitária para suas vidas futuras gerando vontade para alcançá-la.

  20. Ligament augmentation for prevention of proximal junctional kyphosis and proximal junctional failure in adult spinal deformity.

    Science.gov (United States)

    Safaee, Michael M; Deviren, Vedat; Dalle Ore, Cecilia; Scheer, Justin K; Lau, Darryl; Osorio, Joseph A; Nicholls, Fred; Ames, Christopher P

    2018-05-01

    OBJECTIVE Proximal junctional kyphosis (PJK) is a well-recognized, yet incompletely defined, complication of adult spinal deformity surgery. There is no standardized definition for PJK, but most studies describe PJK as an increase in the proximal junctional angle (PJA) of greater than 10°-20°. Ligament augmentation is a novel strategy for PJK reduction that provides strength to the upper instrumented vertebra (UIV) and adjacent segments while also reducing junctional stress at those levels. METHODS In this study, ligament augmentation was used in a consecutive series of adult spinal deformity patients at a single institution. Patient demographics, including age; sex; indication for surgery; revision surgery; surgical approach; and use of 3-column osteotomies, vertebroplasty, or hook fixation at the UIV, were collected. The PJA was measured preoperatively and at last follow-up using 36-inch radiographs. Data on change in PJA and need for revision surgery were collected. Univariate and multivariate analyses were performed to identify factors associated with change in PJA and proximal junctional failure (PJF), defined as PJK requiring surgical correction. RESULTS A total of 200 consecutive patients were included: 100 patients before implementation of ligament augmentation and 100 patients after implementation of this technique. The mean age of the ligament augmentation cohort was 66 years, and 67% of patients were women. Over half of these cases (51%) were revision surgeries, with 38% involving a combined anterior or lateral and posterior approach. The mean change in PJA was 6° in the ligament augmentation group compared with 14° in the control group (p historical cohort, ligament augmentation is associated with a significant decrease in PJK and PJF. These data support the implementation of ligament augmentation in surgery for adult spinal deformity, particularly in patients with a high risk of developing PJK and PJF.

  1. Proximal Alternating Direction Method with Relaxed Proximal Parameters for the Least Squares Covariance Adjustment Problem

    Directory of Open Access Journals (Sweden)

    Minghua Xu

    2014-01-01

    Full Text Available We consider the problem of seeking a symmetric positive semidefinite matrix in a closed convex set to approximate a given matrix. This problem may arise in several areas of numerical linear algebra or come from finance industry or statistics and thus has many applications. For solving this class of matrix optimization problems, many methods have been proposed in the literature. The proximal alternating direction method is one of those methods which can be easily applied to solve these matrix optimization problems. Generally, the proximal parameters of the proximal alternating direction method are greater than zero. In this paper, we conclude that the restriction on the proximal parameters can be relaxed for solving this kind of matrix optimization problems. Numerical experiments also show that the proximal alternating direction method with the relaxed proximal parameters is convergent and generally has a better performance than the classical proximal alternating direction method.

  2. Proximal Hamstring Tendinosis and Partial Ruptures.

    Science.gov (United States)

    Startzman, Ashley N; Fowler, Oliver; Carreira, Dominic

    2017-07-01

    Proximal hamstring tendinosis and partial hamstring origin ruptures are painful conditions of the proximal thigh and hip that may occur in the acute, chronic, or acute on chronic setting. Few publications exist related to their diagnosis and management. This systematic review discusses the incidence, treatment, and prognosis of proximal hamstring tendinosis and partial hamstring ruptures. Conservative treatment measures include nonsteroidal anti-inflammatory drugs, physical therapy, rest, and ice. If these measures fail, platelet-rich plasma or shockwave therapy may be considered. When refractory to conservative management, these injuries may be treated with surgical debridement and hamstring reattachment. [Orthopedics. 2017; 40(4):e574-e582.]. Copyright 2017, SLACK Incorporated.

  3. the impact of proximity to urban center on crop production choice

    African Journals Online (AJOL)

    Rahel

    of the Amhara Regional State in 2006, it has been found that proximity to ... at Department for Agricultural Economics and Rural Development, University of .... major factors for this is believed to be a poorly developed transport network and.

  4. THE PROXIMATE COMPOSITION OF AFRICAN BUSH MANGO ...

    African Journals Online (AJOL)

    BIG TIMMY

    Information regarding previous studies on these physico-chemical ... This behaviour may be attributed to its high myristic acid ... The authors express deep appreciation to the. Heads of ... of a typical rural processing method on the proximate ...

  5. Proximate composition and nutritional characterization of Chia ...

    African Journals Online (AJOL)

    ... dairy product associated with several beneficial nutritional and health effects. ... The results for amino acids showed that the essential and non-essential amino ... proximate composition and nutritional (amino acids, fatty acids, and minerals ...

  6. Proximal focal femoral deficiency: A case report

    Directory of Open Access Journals (Sweden)

    Shashank Sharma

    2015-01-01

    Full Text Available Proximal focal femoral deficiency (PFFD is a rare congenital anomaly resulting in limb shortening and disability in young. The exact cause of the disease is not known and it may present as varying grades of affection involving the proximal femur and the acetabulum. Recognition of this rare abnormality on radiographs can help manage these cases better since early institution of therapy may help in achieving adequate growth of the femur.

  7. Proximity coupling in superconductor-graphene heterostructures

    Science.gov (United States)

    Lee, Gil-Ho; Lee, Hu-Jong

    2018-05-01

    This review discusses the electronic properties and the prospective research directions of superconductor-graphene heterostructures. The basic electronic properties of graphene are introduced to highlight the unique possibility of combining two seemingly unrelated physics, superconductivity and relativity. We then focus on graphene-based Josephson junctions, one of the most versatile superconducting quantum devices. The various theoretical methods that have been developed to describe graphene Josephson junctions are examined, together with their advantages and limitations, followed by a discussion on the advances in device fabrication and the relevant length scales. The phase-sensitive properties and phase-particle dynamics of graphene Josephson junctions are examined to provide an understanding of the underlying mechanisms of Josephson coupling via graphene. Thereafter, microscopic transport of correlated quasiparticles produced by Andreev reflections at superconducting interfaces and their phase-coherent behaviors are discussed. Quantum phase transitions studied with graphene as an electrostatically tunable 2D platform are reviewed. The interplay between proximity-induced superconductivity and the quantum-Hall phase is discussed as a possible route to study topological superconductivity and non-Abelian physics. Finally, a brief summary on the prospective future research directions is given.

  8. [Ophthalmologists in the proximity of Adolf Hitler].

    Science.gov (United States)

    Rohrbach, J M

    2012-10-01

    Adolf Hitler met or at least knew about 5 ophthalmologists. The chair of ophthalmology in Berlin, Walther Löhlein, personally examined Hitler's eyes at least two times. The chair of ophthalmology in Breslau, Walter Dieter, developed "air raid protection spectacles" with the aid of high representatives of the NS-system and probably Adolf Hitler himself. Heinrich Wilhelm Kranz became rector of the universities of Giessen and Frankfurt/Main. He was known as a very strict advocate of the NS-race hygiene. Werner Zabel made plans for Hitler's diet and tried to interfere with Hitler's medical treatment. Finally, Hellmuth Unger was an influential representative of the medical press and a famous writer. Three of his novels with medical topics were made into a film which Hitler probably saw. Hitler had, so to say, a small "ophthalmological proximity" which, however, did not play a significant role for himself or the NS-state. © Georg Thieme Verlag KG Stuttgart · New York.

  9. Proximal supination osteotomy of the first metatarsal for hallux valgus.

    Science.gov (United States)

    Yasuda, Toshito; Okuda, Ryuzo; Jotoku, Tsuyoshi; Shima, Hiroaki; Hida, Takashi; Neo, Masashi

    2015-06-01

    Risk factors for hallux valgus recurrence include postoperative round-shaped lateral edge of the first metatarsal head and postoperative incomplete reduction of the sesamoids. To prevent the occurrence of such conditions, we developed a proximal supination osteotomy of the first metatarsal. Our aim was to describe this novel technique and report the outcomes in this report. Sixty-six patients (83 feet) underwent a distal soft tissue procedure combined with a proximal supination osteotomy. After the proximal crescentic osteotomy, the proximal fragment was pushed medially, and the distal fragment was abducted, and then the distal fragment of the first metatarsal was manually supinated. Outcomes were assessed using the American Orthopaedic Foot & Ankle Society (AOFAS) score and radiographic examinations. The average follow-up duration was 34 (range, 25 to 52) months. The mean AOFAS score improved significantly from 58.0 points preoperatively to 93.8 points postoperatively (P hallux valgus and intermetatarsal angle decreased significantly from 38.6 and 18.0 degrees preoperatively to 11.0 and 7.9 degrees postoperatively, respectively (both, P hallux valgus, defined as a hallux valgus angle ≥ 25 degrees. The rates of occurrence of a positive round sign and incomplete reduction of the sesamoids significantly decreased postoperatively, which may have contributed to the low hallux valgus recurrence rates. We conclude that a proximal supination osteotomy was an effective procedure for correction of hallux valgus and can achieve a low rate of hallux valgus recurrence. Level IV, retrospective case series. © The Author(s) 2015.

  10. Automated space vehicle control for rendezvous proximity operations

    Science.gov (United States)

    Lea, Robert N.

    1988-01-01

    Rendezvous during the unmanned space exploration missions, such as a Mars Rover/Sample Return will require a completely automatic system from liftoff to docking. A conceptual design of an automated rendezvous, proximity operations, and docking system is being implemented and validated at the Johnson Space Center (JSC). The emphasis is on the progress of the development and testing of a prototype system for control of the rendezvous vehicle during proximity operations that is currently being developed at JSC. Fuzzy sets are used to model the human capability of common sense reasoning in decision making tasks and such models are integrated with the expert systems and engineering control system technology to create a system that performs comparably to a manned system.

  11. Processo de criação no fazer musical: uma objetivação da subjetividade, a partir dos trabalhos de Sartre e Vygotsky The process of creation of a musical: an objectification of the subjectivity, based on Sartre and Vygotsky

    Directory of Open Access Journals (Sweden)

    Kátia Maheirie

    2003-12-01

    Full Text Available O sujeito é compreendido neste trabalho como constituído e constituinte do contexto social, e a música como uma linguagem reflexivo-afetiva, capaz de construir sentidos coletivos e singulares. Entendemos como reflexiva toda atividade humana que objetiva predominantemente uma racionalidade; e, como afetivas as objetivações que, embora mediadas por uma racionalidade, contemplam sobremaneira emoções e sentimentos. A partir dos trabalhos de Sartre e Vygotsky, compreendemos que nos processos de criação musical os sujeitos unificam dialeticamente a aprendizagem dos conhecimentos técnicos, numa postura afetiva, a qual implica em relações entre percepção, imaginação, sentimentos e emoções. O músico, no processo criativo, transforma os sons numa objetividade subjetivada, como negação dialética do determinismo de um contexto, já que nele deixa, necessariamente, a marca da sua subjetividade. O processo de criação musical deve ser compreendido sempre como um produto histórico-social, completamente inserido no contexto no qual se dá.In this workthe subject is understood as constituted and constituent of the social context, and the music, as a reflexive-affectionate language, capable to build collective and singular sense. We understand as reflexive every human activity that, above all,aims at a rationality; and, we understand as affectionate the objectifications that, although mediated by a rationality, they contemplate emotions and feelings. Based on works of Sartre and Vygotsky, we understand that in the process of musical creation, the subjects unify dialectically the learning of the technical knowledge, in an affectionate posture, which implicates in relation among perception, imagination, feelings and emotions. The musician, in the creative process, transforms the sounds in a subjectfied objectivity, as a dialectical denial of the determinism of a context, since it he leaves, necessarily, the mark of the his subjectivity. The

  12. Locking plate fixation for proximal humerus fractures.

    LENUS (Irish Health Repository)

    Burke, Neil G

    2012-02-01

    Locking plates are increasingly used to surgically treat proximal humerus fractures. Knowledge of the bone quality of the proximal humerus is important. Studies have shown the medial and dorsal aspects of the proximal humeral head to have the highest bone strength, and this should be exploited by fixation techniques, particularly in elderly patients with osteoporosis. The goals of surgery for proximal humeral fractures should involve minimal soft tissue dissection and achieve anatomic reduction of the head complex with sufficient stability to allow for early shoulder mobilization. This article reviews various treatment options, in particular locking plate fixation. Locking plate fixation is associated with a high complication rate, such as avascular necrosis (7.9%), screw cutout (11.6%), and revision surgery (13.7%). These complications are frequently due to the varus deformation of the humeral head. Strategic screw placement in the humeral head would minimize the possibility of loss of fracture reduction and potential hardware complications. Locking plate fixation is a good surgical option for the management of proximal humerus fractures. Complications can be avoided by using better bone stock and by careful screw placement in the humeral head.

  13. Giant proximity effect in ferromagnetic bilayers

    Science.gov (United States)

    Ramos, Silvia; Charlton, Tim; Quintanilla, Jorge; Suter, Andreas; Moodera, Jagadeesh; Prokscha, Thomas; Salman, Zaher; Forgan, Ted

    2013-03-01

    The proximity effect is a phenomenon where an ordered state leaks from a material into an adjacent one over some finite distance, ξ. For superconductors, this distance is ~ the coherence length. Nevertheless much longer-range, ``giant'' proximity effects have been observed in cuprate junctions. This surprising effect can be understood as a consequence of critical opalescence. Since this occurs near all second order phase transitions, giant proximity effects should be very general and, in particular, they should be present in magnetic systems. The ferromagnetic proximity effect has the advantage that its order parameter (magnetization) can be observed directly. We investigate the above phenomenon in Co/EuS bilayer films, where both materials undergo ferromagnetic transitions but at rather different temperatures (bulk TC of 1400K for Co and 16.6K for EuS). A dramatic increase in the range of the proximity effect is expected near the TC of EuS. We present the results of our measurements of the magnetization profiles as a function of temperature, carried out using the complementary techniques of low energy muon rotation and polarized neutron reflectivity. Work supported by EPSRC, STFC and ONR grant N00014-09-1-0177 and NSF grant DMR 0504158.

  14. Novel implant for peri-prosthetic proximal tibia fractures.

    Science.gov (United States)

    Tran, Ton; Chen, Bernard K; Wu, Xinhua; Pun, Chung Lun

    2018-03-01

    Repair of peri-prosthetic proximal tibia fractures is very challenging in patients with a total knee replacement or arthroplasty. The tibial component of the knee implant severely restricts the fixation points of the tibial implant to repair peri-prosthetic fractures. A novel implant has been designed with an extended flange over the anterior of tibial condyle to provide additional points of fixation, overcoming limitations of existing generic locking plates used for proximal tibia fractures. Furthermore, the screws fixed through the extended flange provide additional support to prevent the problem of subsidence of tibial component of knee implant. The design methodology involved extraction of bone data from CT scans into a flexible CAD format, implant design and structural evaluation and optimisation using FEM as well as prototype development and manufacture by selective laser melting 3D printing technology with Ti6Al4 V powder. A prototype tibia implant was developed based on a patient-specific bone structure, which was regenerated from the CT images of patient's tibia. The design is described in detail and being applied to fit up to 80% of patients, for both left and right sides based on the average dimensions and shape of the bone structure from a wide range of CT images. A novel tibial implant has been developed to repair peri-prosthetic proximal tibia fractures which overcomes significant constraints from the tibial component of existing knee implant. Copyright © 2018 Elsevier Ltd. All rights reserved.

  15. An Integrated Theory of Thinking and Speaking that Draws on Vygotsky and Bakhtin/Vološinov

    Directory of Open Access Journals (Sweden)

    Wolff-Michael Roth

    2013-10-01

    Full Text Available Vygotsky’s social-psychological theory of human development and Bakhtin/Vološinov’s theory of language and the dialogical nature of thought have received increasing interest in the educational research literature but tend to remain unrelated even where co-citation occurs. In this article, I first present a model that integrates the fundamentally common features in the two approaches and present a table with the correspondences of the theoretical terms across four European languages; the model thereby integrates the psychological and sociological dimensions at the heart of the two approaches. I then articulate and elaborate on six main issues that are relevant to and have implications for research: (a sensual life as integrative unit, (b self-movement and development, (c the nested relations between activity and living utterance, (d signification, (e vernacular as the origin and locus of development, and (f unit analysis.

  16. Endomedullar nail of metacarpal and proximal phalanges

    International Nuclear Information System (INIS)

    Mendez Olaya, Francisco Javier; Sanchez Mesa, Pedro Antonio

    2002-01-01

    Prospective study, series of cases; it included patients with diaphysis fractures and union diaphysis-neck or union diaphysis-base of metacarpal and proximal phalanges, in whom was practiced anterograde intramedullary nailing previous closed reduction of the fracture, using prevent intramedullary nail of 1.6 mm. (cem 16) for the metacarpal fractures, and two nail prevent of 1.0 mm. (cem 10) for the proximal phalangeal fractures. Indications: transverse and oblique short fractures, spiral and with comminuting bicortical. Pursuit average is 5.7 months. Frequency surgical intervened patient: 2.2 each month, using this surgical technique a total of 20 (twenty) patients have been operated, 21 (twenty one) fractures; 16 (sixteen) metacarcal fractures and 5 (five) proximal phalangeal fractures, all of them tested using clinical and radiological parameters. Results: good 82%, regular 18%, and bad 0% obtaining bony consolidation and early rehabilitation with incorporation to their habitual works

  17. Correlation between social proximity and mobility similarity.

    Science.gov (United States)

    Fan, Chao; Liu, Yiding; Huang, Junming; Rong, Zhihai; Zhou, Tao

    2017-09-20

    Human behaviors exhibit ubiquitous correlations in many aspects, such as individual and collective levels, temporal and spatial dimensions, content, social and geographical layers. With rich Internet data of online behaviors becoming available, it attracts academic interests to explore human mobility similarity from the perspective of social network proximity. Existent analysis shows a strong correlation between online social proximity and offline mobility similarity, namely, mobile records between friends are significantly more similar than between strangers, and those between friends with common neighbors are even more similar. We argue the importance of the number and diversity of common friends, with a counter intuitive finding that the number of common friends has no positive impact on mobility similarity while the diversity plays a key role, disagreeing with previous studies. Our analysis provides a novel view for better understanding the coupling between human online and offline behaviors, and will help model and predict human behaviors based on social proximity.

  18. Evaluation and Management of Proximal Humerus Fractures

    Directory of Open Access Journals (Sweden)

    Ekaterina Khmelnitskaya

    2012-01-01

    Full Text Available Proximal humerus fractures are common injuries, especially among older osteoporotic women. Restoration of function requires a thorough understanding of the neurovascular, musculotendinous, and bony anatomy. This paper addresses the relevant anatomy and highlights various management options, including indication for arthroplasty. In the vast majority of cases, proximal humerus fractures may be treated nonoperatively. In the case of displaced fractures, when surgical intervention may be pursued, numerous constructs have been investigated. Of these, the proximal humerus locking plate is the most widely used. Arthroplasty is generally reserved for comminuted 4-part fractures, head-split fractures, or fractures with significant underlying arthritic changes. Reverse total shoulder arthroplasty is reserved for patients with a deficient rotator cuff, or highly comminuted tuberosities.

  19. The Life Saving Effects of Hospital Proximity

    DEFF Research Database (Denmark)

    Bertoli, Paola; Grembi, Veronica

    We assess the lifesaving effect of hospital proximity using data on fatality rates of road-traffic accidents. While most of the literature on this topic is based on changes in distance to the nearest hospital triggered by hospital closures and use OLS estimates, our identification comes from......) increases the fatality rate by 13.84% on the sample average. This is equal to a 0.92 additional death per every 100 accidents. We show that OLS estimates provide a downward biased measure of the real effect of hospital proximity because they do not fully solve spatial sorting problems. Proximity matters...... more when the road safety is low; the emergency service is not properly organized, and the nearest hospital has lower quality standards....

  20. Proximity functions for general right cylinders

    International Nuclear Information System (INIS)

    Kellerer, A.M.

    1981-01-01

    Distributions of distances between pairs of points within geometrical objects, or the closely related proximity functions and geometric reduction factors, have applications to dosimetric and microdosimetric calculations. For convex bodies these functions are linked to the chord-length distributions that result from random intersections by straight lines. A synopsis of the most important relations is given. The proximity functions and related functions are derived for right cylinders with arbitrary cross sections. The solution utilizes the fact that the squares of the distances between two random points are sums of independently distributed squares of distances parallel and perpendicular to the axis of the cylinder. Analogous formulas are derived for the proximity functions or geometric reduction factors for a cylinder relative to a point. This requires only a minor modification of the solution

  1. Industrial Computed Tomography using Proximal Algorithm

    KAUST Repository

    Zang, Guangming

    2016-04-14

    In this thesis, we present ProxiSART, a flexible proximal framework for robust 3D cone beam tomographic reconstruction based on the Simultaneous Algebraic Reconstruction Technique (SART). We derive the proximal operator for the SART algorithm and use it for minimizing the data term in a proximal algorithm. We show the flexibility of the framework by plugging in different powerful regularizers, and show its robustness in achieving better reconstruction results in the presence of noise and using fewer projections. We compare our framework to state-of-the-art methods and existing popular software tomography reconstruction packages, on both synthetic and real datasets, and show superior reconstruction quality, especially from noisy data and a small number of projections.

  2. [Partial replantation following proximal limb injury].

    Science.gov (United States)

    Dubert, T; Malikov, S A; Dinh, A; Kupatadze, D D; Oberlin, C; Alnot, J Y; Nabokov, B B

    2000-11-01

    Proximal replantation is a technically feasible but life-threatening procedure. Indications must be restricted to patients in good condition with a good functional prognosis. The goal of replantation must be focused not only on reimplanting the amputated limb but also on achieving a good functional outcome. For the lower limb, simple terminalization remains the best choice in many cases. When a proximal amputation is not suitable for replantation, the main aim of the surgical procedure must be to reconstruct a stump long enough to permit fitting a prosthesis preserving the function of the adjacent joint. If the proximal stump beyond the last joint is very short, it may be possible to restore some length by partial replantation of spared tissues from the amputated part. We present here the results we obtained following this policy. This series included 16 cases of partial replantations, 14 involving the lower limb and 2 the upper limb. All were osteocutaneous microsurgical transfers. For the lower limb, all transfers recovered protective sensitivity following tibial nerve repair. The functional calcaeoplantar unit was used in 13 cases. The transfer of this specialized weight bearing tissue provided a stable distal surface making higher support unnecessary. In one case, we raised a 13-cm vascularized tibial segment covered with foot skin for additional length. For the upper limb, the osteocutaneous transfer, based on the radial artery, was not reinnervated, but this lack of sensitivity did not impair prosthesis fitting. One vascular failure was finally amputated. This was the only unsuccessful result. For all other patients, the surgical procedure facilitated prosthesis fitting and preserved the proximal joint function despite an initially very proximal amputation. The advantages of partial replantation are obvious compared with simple terminalization or secondary reconstruction. There is no secondary donor site and, because there is no major muscle mass in the

  3. Proximity effects in ferromagnet/superconductor structures

    International Nuclear Information System (INIS)

    Yu, H.L.; Sun, G.Y.; Yang, L.Y.; Xing, D.Y.

    2004-01-01

    The Nambu spinor Green's function approach is applied to study proximity effects in ferromagnet/superconductor (FM/SC) structures. They include the induced superconducting order parameter and density of states (DOS) with superconducting feature on the FM side, and spin-dependent DOS within the energy gap on the SC side. The latter indicates an appearance of gapless superconductivity and a coexistence of ferromagnetism and superconductivity in a small regime near the interface. The influence of exchange energy in FM and barrier strength at interface on the proximity effects is discussed

  4. Ultimate and proximate explanations of strong reciprocity.

    Science.gov (United States)

    Vromen, Jack

    2017-08-23

    Strong reciprocity (SR) has recently been subject to heated debate. In this debate, the "West camp" (West et al. in Evol Hum Behav 32(4):231-262, 2011), which is critical of the case for SR, and the "Laland camp" (Laland et al. in Science, 334(6062):1512-1516, 2011, Biol Philos 28(5):719-745, 2013), which is sympathetic to the case of SR, seem to take diametrically opposed positions. The West camp criticizes advocates of SR for conflating proximate and ultimate causation. SR is said to be a proximate mechanism that is put forward by its advocates as an ultimate explanation of human cooperation. The West camp thus accuses advocates of SR for not heeding Mayr's original distinction between ultimate and proximate causation. The Laland camp praises advocates of SR for revising Mayr's distinction. Advocates of SR are said to replace Mayr's uni-directional view on the relation between ultimate and proximate causes by the bi-directional one of reciprocal causation. The paper argues that both the West camp and the Laland camp misrepresent what advocates of SR are up to. The West camp is right that SR is a proximate cause of human cooperation. But rather than putting forward SR as an ultimate explanation, as the West camp argues, advocates of SR believe that SR itself is in need of ultimate explanation. Advocates of SR tend to take gene-culture co-evolutionary theory as the correct meta-theoretical framework for advancing ultimate explanations of SR. Appearances notwithstanding, gene-culture coevolutionary theory does not imply Laland et al.'s notion of reciprocal causation. "Reciprocal causation" suggests that proximate and ultimate causes interact simultaneously, while advocates of SR assume that they interact sequentially. I end by arguing that the best way to understand the debate is by disambiguating Mayr's ultimate-proximate distinction. I propose to reserve "ultimate" and "proximate" for different sorts of explanations, and to use other terms for distinguishing

  5. Infiltrating/sealing proximal caries lesions

    DEFF Research Database (Denmark)

    Martignon, S; Ekstrand, K R; Gomez, J

    2012-01-01

    This randomized split-mouth controlled clinical trial aimed at assessing the therapeutic effects of infiltration vs. sealing for controlling caries progression on proximal surfaces. Out of 90 adult students/patients assessed at university clinics and agreeing to participate, 39, each with 3...... differences in lesion progression between infiltration and placebo (P = 0.0012) and between sealing and placebo (P = 0.0269). The study showed that infiltration and sealing are significantly better than placebo treatment for controlling caries progression on proximal lesions. No significant difference...

  6. Proximal Limb Weakness Reverting After CSF Diversion In Intracranial Hypertension

    Directory of Open Access Journals (Sweden)

    Sinha S

    2005-01-01

    Full Text Available We report about two young girls who developed progressive visual failure secondary to increased intracranial pressure and had significant proximal muscle weakness of limbs. Patients with elevated intracranial pressure (ICP may present with "false localizing signs", besides having headache, vomiting and papilledema. Radicular pain as a manifestation of raised ICP is rare and motor weakness attributable to polyradiculopathy is exceptional. Two patients with increased intracranial pressure without lateralizing signs′ had singnificant muscle weakness. Clinical evaluation and laboratory tests did not disclose any other cause for weakness. Following theco-peritoneal shunt, in both patients, there was variable recovery of vision but the proximal weakness and symptoms of elevated ICP improved rapidly. Recognition of this uncommon manifestation of raised ICP may obviate the need for unnecessary investigation and reduce morbidity due to weakness by CSF diversion procedure.

  7. Nanocrystal Bioassembly: Asymmetry, Proximity, and Enzymatic Manipulation

    Energy Technology Data Exchange (ETDEWEB)

    Claridge, Shelley A. [Univ. of California, Berkeley, CA (United States)

    2008-05-01

    Research at the interface between biomolecules and inorganic nanocrystals has resulted in a great number of new discoveries. In part this arises from the synergistic duality of the system: biomolecules may act as self-assembly agents for organizing inorganic nanocrystals into functional materials; alternatively, nanocrystals may act as microscopic or spectroscopic labels for elucidating the behavior of complex biomolecular systems. However, success in either of these functions relies heavily uponthe ability to control the conjugation and assembly processes.In the work presented here, we first design a branched DNA scaffold which allows hybridization of DNA-nanocrystal monoconjugates to form discrete assemblies. Importantly, the asymmetry of the branched scaffold allows the formation of asymmetric2assemblies of nanocrystals. In the context of a self-assembled device, this can be considered a step toward the ability to engineer functionally distinct inputs and outputs.Next we develop an anion-exchange high performance liquid chromatography purification method which allows large gold nanocrystals attached to single strands of very short DNA to be purified. When two such complementary conjugates are hybridized, the large nanocrystals are brought into close proximity, allowing their plasmon resonances to couple. Such plasmon-coupled constructs are of interest both as optical interconnects for nanoscale devices and as `plasmon ruler? biomolecular probes.We then present an enzymatic ligation strategy for creating multi-nanoparticle building blocks for self-assembly. In constructing a nanoscale device, such a strategy would allow pre-assembly and purification of components; these constructs can also act as multi-label probes of single-stranded DNA conformational dynamics. Finally we demonstrate a simple proof-of-concept of a nanoparticle analog of the polymerase chain reaction.

  8. HUMAN DEVELOPMENT, COGNITION AND SCHOOL EDUCATION: REFLECTIONS BELOW THE HISTORICAL-CULTURAL APPROACH

    Directory of Open Access Journals (Sweden)

    Solange Maria Alves

    2016-07-01

    Full Text Available This text is fruit of studies, reflections and dialogues developed with graduate and post-graduate students inteaching and research coordinated by me, allocated in the research group: Human Development, Culture and Education, in rows : Language, Learning and Development and Imaginary Production and Creative Education. Over several years, the task of educational coordinating processes of teaching and research, allowed the construction of synthesis (always provisional, presented here. Having as a foundation the historic-cultural theory of Vygotsky and collaborators, the text reflects about human development, cognition and school education, pursuing the thesis that cognition is human development. To do this, search, in theoretical foundations of historical-cultural conception, the key elements that explain the process by which the biological becomes socio-historical, it takes up more carefully in the explicit about Vygotsky translates as plans or genetic fields of human development, increase the reflection articulating the categories: labor and language.

  9. Phytochemical screening, proximate analysis and acute toxicity ...

    African Journals Online (AJOL)

    Phytochemical screening results indicate the presence of saponins, flavonoids, phytosterols and phenols. Acute toxicity study showed there was no mortality at 8000 mg/kg of the extract. The results indicate that the plant is rich in phytochemicals and is relatively safe. Key words: Phytochemicals, acute toxicity, proximate ...

  10. PROXIMATE AND ELEMENTAL COMPOSITION OF WHITE GRUBS

    African Journals Online (AJOL)

    DR. AMINU

    This study determined the proximate and mineral element composition of whole white grubs using standard methods of analysis. ... and 12.75 ± 3.65% respectively. Mineral contents of white grub in terms of relative concentration .... of intracellular Ca, bone mineralization, blood coagulation, and plasma membrane potential ...

  11. Phytochemical Screening and Proximate Analysis of Newbouldia ...

    African Journals Online (AJOL)

    The study was conducted to assess the phytochemical and proximate composition of Newboudia laevis leaves and Allium sativum bulb extracts. The leaves and bulbs extracts were analyzed for their chemical composition and antinutritional factors (ANFs) which include moisture, crude protein, crude fat, crude fiber, total ash ...

  12. Phytochemical Screening, Proximate and Mineral Composition of ...

    African Journals Online (AJOL)

    Leaves of sweet potato (Ipomoea batatas) grown in Tepi area was studied for their class of phytochemicals, mineral and proximate composition using standard analytical methods. The phytochemical screening revealed the presence of alkaloids, flavonoid, terpenoids, saponins, quinones, phenol, tannins, amino acid and ...

  13. Phytochemical screening, proximate and elemental analysis of ...

    African Journals Online (AJOL)

    Citrus sinensis was screened for its phytochemical composition and was evaluated for the proximate and elemental analysis. The phytochemical analysis indicated the presence of reducing sugar, saponins, cardiac glycosides, tannins and flavonoids. The elemental analysis indicated the presence of the following mineral ...

  14. Modified Koyanagi Technique in Management of Proximal ...

    African Journals Online (AJOL)

    xp

    Modified Koyanagi Technique in Management of Proximal Hypospadias. Adham Elsaied, Basem Saied, and Mohammed El- ... All operations were performed by the authors,using fine instruments and under 3.5X loupe ... the other needed an operation to close the fistula six months later. The case with meatal recession had ...

  15. Proximity focusing RICH with TOF capabilities

    International Nuclear Information System (INIS)

    Korpar, S.; Adachi, I.; Fujita, K.; Fukushima, T.; Gorisek, A.; Hayashi, D.; Iijima, T.; Ikado, T.; Ishikawa, T.; Kawai, H.; Kozakai, Y.; Krizan, P.; Kuratani, A.; Mazuka, Y.; Nakagawa, T.; Nishida, S.; Ogawa, S.; Pestotnik, R.; Seki, T.; Sumiyoshi, T.; Tabata, M.; Unno, Y.

    2007-01-01

    A proximity focusing RICH counter with a multi-channel micro-channel plate (MCP) PMT was tested as a time-of-flight counter. Cherenkov photons emitted in the radiator medium as well as in the entrance window of the PMT were used for the time-of-flight measurement, and an excellent performance of the counter could be demonstrated

  16. Proximate composition and mycological characterization of peanut ...

    African Journals Online (AJOL)

    SARAH

    2013-12-30

    Dec 30, 2013 ... ABSTRACT. Objective: The aim of this work was to contribute to the food safety of Ivorian consumers by investigating the proximate composition and the toxic fungal contamination of peanut butters offered for retail sale on the different markets of Abidjan. Methodology and results: Peanut butter samples (45) ...

  17. Prosthetic replacement for proximal humeral fractures.

    Science.gov (United States)

    Kontakis, George; Tosounidis, Theodoros; Galanakis, Ioannis; Megas, Panagiotis

    2008-12-01

    The ideal management of complex proximal humeral fractures continues to be debatable. Evolution of proximal humeral fracture management, during the past decade, led to the implementation of many innovations in surgical treatment. Even though the pendulum of treatment seems to swing towards new trends such as locked plating, hemiarthroplasty remains a valid and reliable option that serves the patient's needs well. Hemiarthroplasty is indicated for complex proximal humeral fractures in elderly patients with poor bone stock and when internal fixation is difficult or unreliable. Hemiarthroplasty provides a better result when it is performed early post-injury. Stem height, retroversion and tuberosity positioning are technical aspects of utmost importance. Additionally reverse total shoulder arthroplasty is an alternative new modality that can be used as a primary solution in selected patients with proximal humeral fracture treatment. Failed hemiarthroplasty and fracture sequelae can be successfully managed with reverse total shoulder arthroplasty. Individual decision-making and tailored treatment that takes into consideration the personality of the fracture and the patient's characteristics should be used.

  18. Phytochemistry and proximate composition of ginger ( Zingiber ...

    African Journals Online (AJOL)

    The results of the phytochemical screening showed that alkaloids, carbohydrates, glycosides, proteins, saponins, steroids, flavonoids and terpenoids were present, while reducing sugars, tannins, oils and acid compounds were absent. Similarly, the results of the proximate analysis of the rhizome showed that ginger ...

  19. Disability occurrence and proximity to death

    NARCIS (Netherlands)

    Klijs, Bart; Mackenbach, Johan P.; Kunst, Anton E.

    2010-01-01

    Purpose. This paper aims to assess whether disability occurrence is related more strongly to proximity to death than to age. Method. Self reported disability and vital status were available from six annual waves and a subsequent 12-year mortality follow-up of the Dutch GLOBE longitudinal study.

  20. Proximate composition, bread characteristics and sensory ...

    African Journals Online (AJOL)

    This study was carried out to investigate proximate composition, bread characteristics and sensory evaluation of cocoyam-wheat composite breads at different levels of cocoyam flour substitution for human consumption.A whole wheat bread (WWB) and cocoyam-composite breads (CCB1,CCB 2 and CCB 3) were prepared ...

  1. Proximal focal femoral deficiency: evaluation by MR imaging

    International Nuclear Information System (INIS)

    Biko, David M.; Davidson, Richard; Pena, Andres; Jaramillo, Diego

    2012-01-01

    Proximal focal femoral deficiency (PFFD) is a rare congenital anomaly characterized by abnormal development of the proximal femur. The most common radiographic classification (Aitken) does not evaluate the cartilaginous and soft-tissue abnormalities. To demonstrate MR findings of PFFD focusing on features not seen with radiographs. Nine MR examinations of the hip and femurs of seven children with PFFD were retrospectively reviewed. Imaging was quantitatively and qualitatively assessed comparing the affected limb to the contralateral limb and age-matched controls. The children were classified via the Aitken classification. All children had at least mild acetabular dysplasia, and one type D patient had no acetabulum. MR demonstrated that 4/6 children had labral hypertrophy with a decreased distance from the greater trochanter to the acetabular rim, suggesting impingement (P < 0.05). The proximal femoral physis was abnormal in all cases. The connection between the femoral head and shaft if present was fibrous or fibrocartilaginous. MRI can help in evaluation of PFFD by defining the anatomy. MR demonstrates features of the acetabulum and cartilaginous femoral epiphysis and depicts ligamentous abnormalities of the knee. (orig.)

  2. Proximal focal femoral deficiency: evaluation by MR imaging

    Energy Technology Data Exchange (ETDEWEB)

    Biko, David M. [National Naval Medical Center, Department of Radiology, Bethesda, MD (United States); Uniformed Services University of Health Sciences, Department of Radiology and Radiological Sciences, Bethesda, MD (United States); Davidson, Richard [The Children' s Hospital of Philadelphia, Department of Orthopedic Surgery, Philadelphia, PA (United States); Pena, Andres; Jaramillo, Diego [The Children' s Hospital of Philadelphia, Department of Radiology, Philadelphia, PA (United States)

    2012-01-15

    Proximal focal femoral deficiency (PFFD) is a rare congenital anomaly characterized by abnormal development of the proximal femur. The most common radiographic classification (Aitken) does not evaluate the cartilaginous and soft-tissue abnormalities. To demonstrate MR findings of PFFD focusing on features not seen with radiographs. Nine MR examinations of the hip and femurs of seven children with PFFD were retrospectively reviewed. Imaging was quantitatively and qualitatively assessed comparing the affected limb to the contralateral limb and age-matched controls. The children were classified via the Aitken classification. All children had at least mild acetabular dysplasia, and one type D patient had no acetabulum. MR demonstrated that 4/6 children had labral hypertrophy with a decreased distance from the greater trochanter to the acetabular rim, suggesting impingement (P < 0.05). The proximal femoral physis was abnormal in all cases. The connection between the femoral head and shaft if present was fibrous or fibrocartilaginous. MRI can help in evaluation of PFFD by defining the anatomy. MR demonstrates features of the acetabulum and cartilaginous femoral epiphysis and depicts ligamentous abnormalities of the knee. (orig.)

  3. Links between casino proximity and gambling participation, expenditure, and pathology.

    Science.gov (United States)

    Sévigny, Serge; Ladouceur, Robert; Jacques, Christian; Cantinotti, Michael

    2008-06-01

    Two studies investigated the relationship between casino proximity and gambling participation, expenditure, and pathology. In Study 1, 8,842 participants were categorized into 1 of 4 driving distances from their home to the nearest casino in the province of Quebec: 0-100 km, 100.01-200 km, 200.01-300 km, or 300.01-981 km. In Study 2, 5,158 participants, who lived within a 100-km driving distance from the Montreal casino, were classified into 1 of 5 equidistant, 20-km driving distances. A survey company interviewed participants regarding their gambling habits. Results indicated a positive link between casino proximity and gambling participation (at the provincial and Montreal levels) and expenditure (at the provincial level only) but no link with the current prevalence rate of probable pathological gambling or of problem gambling. In a setting in which many types of gambling activities are available, casino proximity in itself does not appear to explain the rate of gambling-related problems. It is necessary to continue prospective research on exposure and adaptation theories as potential explanations for the development of pathological gambling. 2008 APA

  4. Cyclophilin B expression in renal proximal tubules of hypertensive rats.

    Science.gov (United States)

    Kainer, D B; Doris, P A

    2000-04-01

    Rat cyclophilin-like protein (Cy-LP) is a candidate hypertension gene initially identified by differential hybridization and implicated in renal mechanisms of salt retention and high blood pressure. We report the molecular characterization of rat cyclophilin B (CypB) and demonstrate, through sequence analysis and an allele-specific polymerase chain reaction primer assay, that CypB but not Cy-LP is expressed in rat kidney. CypB is an endoplasmic reticulum-localized prolyl-isomerase that interacts with elongation initiation factor 2-beta, an important regulator of protein translation and a central component of the endoplasmic reticulum stress response to hypoxia or ATP depletion. Active renal transport of sodium is increased in the spontaneously hypertensive rat (SHR), and there is evidence that this coincides with hypoxia and ATP depletion in the renal cortex. In the present studies we have examined expression of CypB in rat proximal tubules, which contributes to the increased renal sodium reabsorption in this model of hypertension. We report that CypB transcript abundance is significantly elevated in proximal convoluted tubules from SHR compared with the control Wistar-Kyoto strain. This upregulation occurs in weanling animals and precedes the development of hypertension, indicating that it is not a simple response to hypertension in SHR. Further, CypB expression is also higher in a proximal tubule cell line derived from SHR compared with a similar line derived from Wistar-Kyoto rats, indicating that this difference is genetically determined. No sequence differences were observed in the CypB cDNA from these 2 strains. These observations suggest that a genetically determined alteration in proximal tubules from SHR occurs that leads to increased expression of CypB. In view of evidence linking CypB to the regulation of elongation initiation factor-2, the upregulation of CypB may result from metabolic stress.

  5. Electromagnetic Signal Feedback Control for Proximity Detection Systems

    Science.gov (United States)

    Smith, Adam K.

    Coal is the most abundant fossil fuel in the United States and remains an essential source of energy. While more than half of coal production comes from surface mining, nearly twice as many workers are employed by underground operations. One of the key pieces of equipment used in underground coal mining is the continuous mining machine. These large and powerful machines are operated in confined spaces by remote control. Since 1984, 40 mine workers in the U. S. have been killed when struck or pinned by a continuous mining machine. It is estimated that a majority of these accidents could have been prevented with the application of proximity detection systems. While proximity detection systems can significantly increase safety around a continuous mining machine, there are some system limitations. Commercially available proximity warning systems for continuous mining machines use magnetic field generators to detect workers and establish safe work areas around the machines. Several environmental factors, however, can influence and distort the magnetic fields. To minimize these effects, a control system has been developed using electromagnetic field strength and generator current to stabilize and control field drift induced by internal and external environmental factors. A laboratory test set-up was built using a ferrite-core magnetic field generator to produce a stable magnetic field. Previous work based on a field-invariant magnetic flux density model, which generically describes the electromagnetic field, is expanded upon. The analytically established transferable shell-based flux density distribution model is used to experimentally validate the control system. By controlling the current input to the ferrite-core generator, a more reliable and consistent magnetic field is produced. Implementation of this technology will improve accuracy and performance of existing commercial proximity detection systems. These research results will help reduce the risk of traumatic

  6. [Imaging evaluation on adaptability of proximal humeral anatomy after shoulder replacement with individualized shoulder prosthesis].

    Science.gov (United States)

    Shi, Youxing; Tang, Kanglai; Yuan, Chengsong; Tao, Xu; Wang, Huaqing; Chen, Bo; Guo, Yupeng

    2015-03-24

    Modern shoulder prosthesis has evolved through four generations. And the fourth generation technology has a core three-dimensional design of restoring 3D reconstruction of proximal humeral anatomy. Thus a new shoulder prosthesis is developed on the basis of the technology of 3D prosthesis. Assessment of whether shoulder prosthesis can restore individualized reconstruction of proximal humeral anatomy is based on the adaptability of proximal humeral anatomy. To evaluate the adaptability of proximal humeral anatomy through measuring the parameters of proximal humeral anatomy after shoulder replacement with individualized shoulder prosthesis and compare with normal data. The parameters of proximal humeral anatomy were analyzed and evaluated for a total of 12 cases undergoing shoulder replacement with individualized shoulder prosthesis. The relevant anatomical parameters included neck-shaft angle (NSA), retroversion angle (RA), humeral head height (HH) and humeral head diameter (HD). And the anatomical parameters were compared with the data from normal side. All underwent shoulder replacement with individualized shoulder prosthesis. The postoperative parameters of proximal humeral anatomy were compared with those of normal side. And the difference of NSA was 0.05). Individualized shoulder prosthesis has excellent adaptability to shoulder. All core parameters are freely adjustable and specification models may be optimized. With matching tools, individualized shoulder prosthesis improves the accuracy and reliability in shoulder replacement.

  7. Rapid population growth and environmental degradation: ultimate versus proximate factors.

    Science.gov (United States)

    Shaw, R P

    1989-01-01

    This philosophical review of 2 arguments about responsibility for and solutions to environmental degradation concludes that both sides are correct: the ultimate and the proximal causes. Ultimate causes of pollution are defined as the technology responsible for a given type of pollution, such as burning fossil fuel; proximate causes are defined as situation-specific factors confounding the problem, such as population density or rate of growth. Commoner and others argue that developed countries with low or negative population growth rates are responsible for 80% of world pollution, primarily in polluting technologies such as automobiles, power generation, plastics, pesticides, toxic wastes, garbage, warfaring, and nuclear weapons wastes. Distortionary policies also contribute; examples are agricultural trade protection, land mismanagement, urban bias in expenditures, and institutional rigidity., Poor nations are responsible for very little pollution because poverty allows little waste or expenditures for polluting, synthetic technologies. The proximal causes of pollution include numbers and rate of growth of populations responsible for the pollution. Since change in the ultimate cause of pollution remains out of reach, altering the numbers of polluters can make a difference. Predictions are made for proportions of the world's total waste production, assuming current 1.6 tons/capita for developed countries and 0.17 tons/capita for developing countries. If developing countries grow at current rates and become more wealthy, they will be emitting half the world's waste by 2025. ON the other hand, unsustainable population growth goes along with inadequate investment in human capital: education, health, employment, infrastructure. The solution is to improve farming technologies in the 117 non-self-sufficient countries, fund development in the most unsustainable enclaves of growing countries, break institutionalized socio-political rigidity in these enclaves, and focus on

  8. Proximal tubular hypertrophy and enlarged glomerular and proximal tubular urinary space in obese subjects with proteinuria.

    Directory of Open Access Journals (Sweden)

    Ana Tobar

    Full Text Available BACKGROUND: Obesity is associated with glomerular hyperfiltration, increased proximal tubular sodium reabsorption, glomerular enlargement and renal hypertrophy. A single experimental study reported an increased glomerular urinary space in obese dogs. Whether proximal tubular volume is increased in obese subjects and whether their glomerular and tubular urinary spaces are enlarged is unknown. OBJECTIVE: To determine whether proximal tubules and glomerular and tubular urinary space are enlarged in obese subjects with proteinuria and glomerular hyperfiltration. METHODS: Kidney biopsies from 11 non-diabetic obese with proteinuria and 14 non-diabetic lean patients with a creatinine clearance above 50 ml/min and with mild or no interstitial fibrosis were retrospectively analyzed using morphometric methods. The cross-sectional area of the proximal tubular epithelium and lumen, the volume of the glomerular tuft and of Bowman's space and the nuclei number per tubular profile were estimated. RESULTS: Creatinine clearance was higher in the obese than in the lean group (P=0.03. Proteinuria was similarly increased in both groups. Compared to the lean group, the obese group displayed a 104% higher glomerular tuft volume (P=0.001, a 94% higher Bowman's space volume (P=0.003, a 33% higher cross-sectional area of the proximal tubular epithelium (P=0.02 and a 54% higher cross-sectional area of the proximal tubular lumen (P=0.01. The nuclei number per proximal tubular profile was similar in both groups, suggesting that the increase in tubular volume is due to hypertrophy and not to hyperplasia. CONCLUSIONS: Obesity-related glomerular hyperfiltration is associated with proximal tubular epithelial hypertrophy and increased glomerular and tubular urinary space volume in subjects with proteinuria. The expanded glomerular and urinary space is probably a direct consequence of glomerular hyperfiltration. These effects may be involved in the pathogenesis of obesity

  9. Cultural-historical and cognitive approaches to understanding the origins of development of written speech

    Directory of Open Access Journals (Sweden)

    L.F. Obukhova

    2014-08-01

    Full Text Available We present an analysis of the emergence and development of written speech, its relationship to the oral speech, connections to the symbolic and modeling activities of preschool children – playing and drawing. While a child's drawing is traditionally interpreted in psychology either as a measure of intellectual development, or as a projective technique, or as a criterion for creative giftedness of the child, in this article, the artistic activity is analyzed as a prerequisite for development of written speech. The article substantiates the hypothesis that the mastery of “picture writing” – the ability to display the verbal content in a schematic picturesque plan – is connected to the success of writing speech at school age. Along with the classical works of L.S. Vygotsky, D.B. Elkonin, A.R. Luria, dedicated to finding the origins of writing, the article presents the current Russian and foreign frameworks of forming the preconditions of writing, based on the concepts of cultural-historical theory (“higher mental functions”, “zone of proximal development”, etc.. In Western psychology, a number of pilot studies used the developmental function of drawing for teaching the written skills to children of 5-7 years old. However, in cognitive psychology, relationship between drawing and writing is most often reduced mainly to the analysis of general motor circuits. Despite the recovery in research on writing and its origins in the last decade, either in domestic or in foreign psychology, the written speech is not a sufficiently studied problem.

  10. Cancer in proximity to TV towers

    International Nuclear Information System (INIS)

    Hocking, B.; Gordon, I.; Hatfield, G.

    1996-01-01

    Full text: The effects of low level electro-magnetic fields on cancer development are controversial. There have been few epidemiological studies on the effects of radio-frequency radiation (RFR) and differing conclusions on possible detrimental health effects in humans (Goldsmith, Int. J Occ. and Env. Hlth, 1:47-57, 1995) (WHO, Env. Health Criteria 137). An unusual opportunity to assess possible risks further arose as cancer data (1972-1990) became available covering an area of North Sydney where three TV towers are located in a populated locality. An analysis of data was undertaken comparing cancer incidence and mortality in the three municipalities which immediately surround the TV towers compared to the adjacent three surrounding municipalities. Methods Data for the RFR sources on the towers was obtained (Dept. of Communications, Radio and TV Stations, 1994). The combined field strengths of the video and audio from the three towers and four channels at increasing distances were calculated (NCRP Report 119). Data from the NSW Cancer Registry on incidence, mortality and residence for 1972-1990 available via Healthwiz were extracted by municipality and for sex and age bands 0-14, 15-69 and 70+. Privacy reasons limit the availability of more refined data. The data were examined using a Poisson regression model (Frome EL, Biometrics, 39:665-74, 1983) with the numbers of cases or deaths regarded as Poisson random variables, whose mean is a product of the person years for the observation, and functions of the variables. The variables used were age categories, sex, calendar period (1972-78, 1979-84 and 1985-90), and area (inner 0-4 km and outer 4-12 km). To compare with the whole of NSW standardised incidence ratios and standardised mortality ratios were calculated. Confidence intervals were calculated using the 'exact' method (Liddell FDK, J. Epid. and Comm. Health, 38:85-88, 1984). Calculated field strengths are well below the limits prescribed in the Australian

  11. SINA: A test system for proximity fuses

    Science.gov (United States)

    Ruizenaar, M. G. A.

    1989-04-01

    SINA, a signal generator that can be used for testing proximity fuses, is described. The circuitry of proximity fuses is presented; the output signal of the RF circuit results from a mixing of the emitted signal and received signal that is Doppler shifted in frequency by the relative motion of the fuse with respect to the reflecting target of surface. With SINA, digitized and stored target and clutter signals (previously measured) can be transformed to Doppler signals, for example during a real flight. SINA can be used for testing fuse circuitry, for example in the verification of results of computer simulations of the low frequency Doppler signal processing. The software of SINA and its use are explained.

  12. Isolated Proximal Tibiofibular Dislocation during Soccer

    Directory of Open Access Journals (Sweden)

    Casey Chiu

    2015-01-01

    Full Text Available Proximal tibiofibular dislocations are rarely encountered in the Emergency Department (ED. We present a case involving a man presenting to the ED with left knee pain after making a sharp left turn on the soccer field. His physical exam was only remarkable for tenderness over the lateral fibular head. His X-rays showed subtle abnormalities of the tibiofibular joint. The dislocation was reduced and the patient was discharged from the ED with orthopedic follow-up.

  13. Superconducting proximity effect in topological materials

    Science.gov (United States)

    Reeg, Christopher R.

    In recent years, there has been a renewed interest in the proximity effect due to its role in the realization of topological superconductivity. In this dissertation, we discuss several results that have been obtained in the field of proximity-induced superconductivity and relate the results to the search for Majorana fermions. First, we show that repulsive electron-electron interactions can induce a non-Majorana zero-energy bound state at the interface between a conventional superconductor and a normal metal. We show that this state is very sensitive to disorder, owing to its lack of topological protection. Second, we show that Rashba spin-orbit coupling, which is one of the key ingredients in engineering a topological superconductor, induces triplet pairing in the proximity effect. When the spin-orbit coupling is strong (i.e., when the characteristic energy scale for spin-orbit coupling is comparable to the Fermi energy), the induced singlet and triplet pairing amplitudes can be comparable in magnitude. Finally, we discuss how the size of the proximity-induced gap, which appears in a low-dimensional material coupled to a superconductor, evolves as the thickness of the (quasi-)low-dimensional material is increased. We show that the induced gap can be comparable to the bulk energy gap of the underlying superconductor in materials that are much thicker than the Fermi wavelength, even in the presence of an interfacial barrier and strong Fermi surface mismatch. This result has important experimental consequences for topological superconductivity, as a sizable gap is required to isolate and detect the Majorana modes.

  14. [Proximity and breastfeeding at the maternity hospital].

    Science.gov (United States)

    Fradin-Charrier, Anne-Claire

    2015-01-01

    The establishment of breastfeeding, as well as its duration, are facilitated through the proximity of the mother with her new baby. However, in maternity hospitals, breastfeeding mothers very often leave their baby in the nursery at night time. A study carried out in 2014 in several maternity hospitals put forward suggestions and highlighted areas to improve in everyday practice. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  15. Proximity effects in topological insulator heterostructures

    International Nuclear Information System (INIS)

    Li Xiao-Guang; Wu Guang-Fen; Zhang Gu-Feng; Culcer Dimitrie; Zhang Zhen-Yu; Chen Hua

    2013-01-01

    Topological insulators (TIs) are bulk insulators that possess robust helical conducting states along their interfaces with conventional insulators. A tremendous research effort has recently been devoted to Tl-based heterostructures, in which conventional proximity effects give rise to a series of exotic physical phenomena. This paper reviews our recent studies on the potential existence of topological proximity effects at the interface between a topological insulator and a normal insulator or other topologically trivial systems. Using first-principles approaches, we have realized the tunability of the vertical location of the topological helical state via intriguing dual-proximity effects. To further elucidate the control parameters of this effect, we have used the graphene-based heterostructures as prototypical systems to reveal a more complete phase diagram. On the application side of the topological helical states, we have presented a catalysis example, where the topological helical state plays an essential role in facilitating surface reactions by serving as an effective electron bath. These discoveries lay the foundation for accurate manipulation of the real space properties of the topological helical state in TI-based heterostructures and pave the way for realization of the salient functionality of topological insulators in future device applications. (topical review - low-dimensional nanostructures and devices)

  16. [Augmentation technique on the proximal humerus].

    Science.gov (United States)

    Scola, A; Gebhard, F; Röderer, G

    2015-09-01

    The treatment of osteoporotic fractures is still a challenge. The advantages of augmentation with respect to primary in vitro stability and the clinical use for the proximal humerus are presented in this article. In this study six paired human humeri were randomized into an augmented and a non-augmented group. Osteosynthesis was performed with a PHILOS plate (Synthes®). In the augmented group the two screws finding purchase in the weakest cancellous bone were augmented. The specimens were tested in a 3-part fracture model in a varus bending test. The augmented PHILOS plates withstood significantly more load cycles until failure. The correlation to bone mineral density (BMD) showed that augmentation could partially compensate for low BMD. The augmentation of the screws in locked plating in a proximal humerus fracture model is effective in improving the primary stability in a cyclic varus bending test. The targeted augmentation of two particular screws in a region of low bone quality within the humeral head was almost as effective as four screws with twice the amount of bone cement. Screw augmentation combined with a knowledge of the local bone quality could be more effective in enhancing the primary stability of a proximal humerus locking plate because the effect of augmentation can be exploited more effectively limiting it to the degree required. The technique of augmentation is simple and can be applied in open and minimally invasive procedures. When the correct procedure is used, complications (cement leakage into the joint) can be avoided.

  17. A proximity effect in adults' contamination intuitions

    Directory of Open Access Journals (Sweden)

    Laura R. Kim

    2011-04-01

    Full Text Available Magical beliefs about contagion via contact (Rozin, Nemeroff, Wane, and Sherrod, 1989 may emerge when people overgeneralize real-world mechanisms of contamination beyond their appropriate boundaries (Lindeman and Aarnio, 2007. Do people similarly overextend knowledge of airborne contamination mechanisms? Previous work has shown that very young children believe merely being close to a contamination source can contaminate an item (Springer and Belk 1994; we asked whether this same hyper-avoidant intuition is also reflected in adults' judgments. In two studies, we measured adults' ratings of the desirability of an object that had made contact with a source of contamination, an object nearby that had made no contact with the contaminant, and an object far away that had also made no contact. Adults showed a clear proximity effect, wherein objects near the contamination source were perceived to be less desirable than those far away, even though a separate group of adults unanimously acknowledged that contaminants could not possibly have made contact with either the nearby or far-away object (Study 1. The proximity effect also remained robust when a third group of adults was explicitly told that no contaminating particles had made contact with the objects at any time (Study 2. We discuss implications of our findings for extending the scope of magical contagion effects beyond the contact principle, for understanding the persistence of intuitive theories despite broad acceptance of science-based theories, and for constraining interpretations of the developmental work on proximity beliefs.

  18. A Regularized Algorithm for the Proximal Split Feasibility Problem

    Directory of Open Access Journals (Sweden)

    Zhangsong Yao

    2014-01-01

    Full Text Available The proximal split feasibility problem has been studied. A regularized method has been presented for solving the proximal split feasibility problem. Strong convergence theorem is given.

  19. Treatment of proximal ulna and olecranon fractures by dorsal plating

    NARCIS (Netherlands)

    Kloen, Peter; Buijze, Geert A.

    2009-01-01

    OBJECTIVE : Anatomic reconstruction of proximal ulna and olecranon fractures allowing early mobilization and prevention of ulnohumeral arthritis. INDICATIONS : Comminuted olecranon or proximal ulna fractures (including Monteggia fractures), olecranon fractures extending distally from the coronoid

  20. Strong Proximities on Smooth Manifolds and Vorono\\" i Diagrams

    OpenAIRE

    Peters, J. F.; Guadagni, C.

    2015-01-01

    This article introduces strongly near smooth manifolds. The main results are (i) second countability of the strongly hit and far-miss topology on a family $\\mathcal{B}$ of subsets on the Lodato proximity space of regular open sets to which singletons are added, (ii) manifold strong proximity, (iii) strong proximity of charts in manifold atlases implies that the charts have nonempty intersection. The application of these results is given in terms of the nearness of atlases and charts of proxim...

  1. Critical Proximity as a Methodological Move in Techno-Anthropology

    DEFF Research Database (Denmark)

    Birkbak, Andreas; Petersen, Morten Krogh; Elgaard Jensen, Torben

    2015-01-01

    proximity.’ Critical proximity offers an alternative to critical distance, especially with respect to avoiding premature references to abstract panoramas such as democratization and capitalist exploitation in the quest to conduct ‘critical’ analysis. Critical proximity implies, instead, granting the beings...

  2. 75 FR 5009 - Proximity Detection Systems for Underground Mines

    Science.gov (United States)

    2010-02-01

    ... Proximity Detection Systems for Underground Mines AGENCY: Mine Safety and Health Administration, Labor... information regarding whether the use of proximity detection systems would reduce the risk of accidents where... . Information on MSHA-approved proximity detection systems is available on the Internet at http://www.msha.gov...

  3. Design of intelligent proximity detection zones to prevent striking and pinning fatalities around continuous mining machines.

    Science.gov (United States)

    Bissert, P T; Carr, J L; DuCarme, J P; Smith, A K

    2016-01-01

    The continuous mining machine is a key piece of equipment used in underground coal mining operations. Over the past several decades these machines have been involved in a number of mine worker fatalities. Proximity detection systems have been developed to avert hazards associated with operating continuous mining machines. Incorporating intelligent design into proximity detection systems allows workers greater freedom to position themselves to see visual cues or avoid other hazards such as haulage equipment or unsupported roof or ribs. However, intelligent systems must be as safe as conventional proximity detection systems. An evaluation of the 39 fatal accidents for which the Mine Safety and Health Administration has published fatality investigation reports was conducted to determine whether the accident may have been prevented by conventional or intelligent proximity. Multiple zone configurations for the intelligent systems were studied to determine how system performance might be affected by the zone configuration. Researchers found that 32 of the 39 fatalities, or 82 percent, may have been prevented by both conventional and intelligent proximity systems. These results indicate that, by properly configuring the zones of an intelligent proximity detection system, equivalent protection to a conventional system is possible.

  4. Proximity to sports facilities and sports participation for adolescents in Germany.

    Directory of Open Access Journals (Sweden)

    Anne K Reimers

    Full Text Available To assess the relationship between proximity to specific sports facilities and participation in the corresponding sports activities for adolescents in Germany.A sample of 1,768 adolescents aged 11-17 years old and living in 161 German communities was examined. Distances to the nearest sports facilities were calculated as an indicator of proximity to sports facilities using Geographic Information Systems (GIS. Participation in specific leisure-time sports activities in sports clubs was assessed using a self-report questionnaire and individual-level socio-demographic variables were derived from a parent questionnaire. Community-level socio-demographics as covariates were selected from the INKAR database, in particular from indicators and maps on land development. Logistic regression analyses were conducted to examine associations between proximity to the nearest sports facilities and participation in the corresponding sports activities.The logistic regression analyses showed that girls residing longer distances from the nearest gym were less likely to engage in indoor sports activities; a significant interaction between distances to gyms and level of urbanization was identified. Decomposition of the interaction term showed that for adolescent girls living in rural areas participation in indoor sports activities was positively associated with gym proximity. Proximity to tennis courts and indoor pools was not associated with participation in tennis or water sports, respectively.Improved proximity to gyms is likely to be more important for female adolescents living in rural areas.

  5. Proximity to Sports Facilities and Sports Participation for Adolescents in Germany

    Science.gov (United States)

    Reimers, Anne K.; Wagner, Matthias; Alvanides, Seraphim; Steinmayr, Andreas; Reiner, Miriam; Schmidt, Steffen; Woll, Alexander

    2014-01-01

    Objectives To assess the relationship between proximity to specific sports facilities and participation in the corresponding sports activities for adolescents in Germany. Methods A sample of 1,768 adolescents aged 11–17 years old and living in 161 German communities was examined. Distances to the nearest sports facilities were calculated as an indicator of proximity to sports facilities using Geographic Information Systems (GIS). Participation in specific leisure-time sports activities in sports clubs was assessed using a self-report questionnaire and individual-level socio-demographic variables were derived from a parent questionnaire. Community-level socio-demographics as covariates were selected from the INKAR database, in particular from indicators and maps on land development. Logistic regression analyses were conducted to examine associations between proximity to the nearest sports facilities and participation in the corresponding sports activities. Results The logisitic regression analyses showed that girls residing longer distances from the nearest gym were less likely to engage in indoor sports activities; a significant interaction between distances to gyms and level of urbanization was identified. Decomposition of the interaction term showed that for adolescent girls living in rural areas participation in indoor sports activities was positively associated with gym proximity. Proximity to tennis courts and indoor pools was not associated with participation in tennis or water sports, respectively. Conclusions Improved proximity to gyms is likely to be more important for female adolescents living in rural areas. PMID:24675689

  6. The Graduate Pedagogical Process in the Comprehensive General Medicine Specialization: towards a Practice based on the Cultural-historical Approach to Human Development

    OpenAIRE

    Ana Teresa Fernández Vidal; José Aurelio Díaz Quiñones; Silvia Enrique Vilaplana

    2016-01-01

    Cuban educators conceive programs and processes using the cultural-historical approach to human development, since this is the theory that, thanks to its founder Lev Semiónovich Vygotsky, could overcome the approaches that fragmented the analysis and understanding of the human development. Such currents of thought hyperbolized the different conditioning factors of this development and ignored the dialectical relationship between them in terms of personality formation and development, its proc...

  7. Keldysh proximity action for disordered superconductors

    International Nuclear Information System (INIS)

    Feigel'man, M.V.; Larkin, A.I.; Skvortsov, M.A.

    2005-01-01

    We review a novel approach to the superconductive proximity effect in disordered normal-superconducting (N-S) structures. The method is based on the multicharge Keldysh action and is suitable for the treatment of interaction and fluctuation effects. As an application of the formalism, we study the subgap conductance and noise in two-dimensional N-S system in the presence of the electron-electron interaction in the Cooper channel. It is shown that singular nature of the interaction correction at large scales leads to a nonmonotonous temperature, voltage and magnetic field dependence of the Andreev conductance. (author)

  8. Proximal iliotibial band syndrome: case report

    Directory of Open Access Journals (Sweden)

    Guilherme Guadagnini Falotico

    2013-08-01

    Full Text Available OBJECTIVE: The overuse injuries in the hip joint occur commonly in sports practitioners and currently due to technical advances in diagnostic imaging, especially magnetic resonance imaging (MRI, are often misdiagnosed. Recently, a group of people were reported, all female, with pain and swelling in the pelvic region.T2-weighted MRI showed increased signal in the enthesis of the iliotibial band (ITB along the lower border of the iliac tubercle. We report a case of a 34 year old woman, non-professional runner, with pain at the iliac crest with no history of trauma and whose MRI was compatible with the proximal iliotibial band syndrome.

  9. Noise measurements on proximity effect bridges

    International Nuclear Information System (INIS)

    Decker, S.K.; Mercereau, J.E.

    1975-01-01

    Audio frequency noise density measurements were performed on weakly superconducting proximity effect bridges on using a cooled transformer and room temperature low noise preamplifier. The noise temperature of the measuring system is approximately 4 0 K for a 0.9 Ω resistor. Noise density was measured as a function of bias current and temperature for the bridges. Excess noise above that expected from Johnson noise for a resistor equal to the dynamic resistance of the bridges was observed in the region near the critical current of the device. At high currents compared to the critical current, the noise density closely approaches that given by Johnson noise

  10. Clinicopathologic characteristics and prognosis of proximal and distal gastric cancer

    Directory of Open Access Journals (Sweden)

    Yu X

    2018-02-01

    Full Text Available Xuefeng Yu,1,* Fulan Hu,2,* Chunfeng Li,1 Qiang Yao,1 Hongfeng Zhang,1 Yingwei Xue1 1Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, China; 2Department of Epidemiology, Public Health College, Harbin Medical University, Harbin, China *These authors contributed equally to this work Background and objectives: The dismal prognosis of gastric cancer patients is a global problem. We aim to evaluate the clinicopathologic features and prognostic factors of proximal and distal gastric cancer.Materials and methods: Gastric cancer cases diagnosed and treated at the same surgical unit between 2007 and 2010 were reviewed. Follow-up data from all patients were collected for at least 5 years until 2015. A total of 964 patients were studied (distal gastric cancer [DG], n=777 and proximal gastric cancer [PG], n=187.Results: DG patients had a relatively higher percentage of females, more thorough therapy (R0 [D0/D1/D2], fewer combined organ resections, younger age, smaller tumors (<5 cm, shorter surgery durations, less blood loss during surgery, and a relatively lower percentage of nodal metastases and a TNM stage of 4 (p<0.05. A significantly higher 5-year survival rate was observed in DG patients compared to PG patients (DG: 51%, PG: 28%; p<0.001. A multivariate analysis demonstrated that tumor size, blood loss during surgery, surgery approach of lymph node dissection, treatment with palliative surgery, histopathologic type, TNM stage, and tumor location were independent predictors of poor outcome.Conclusion: The different characteristics and prognosis of DG and PG cases have implications for the development of guiding strategies for a surgical program and assessment of prognosis of gastric cancer patients based on tumor location. Keywords: gastric cancer, tumor location, clinicopathologic features, prognosis, distal gastric cancer, proximal gastric cancer 

  11. Capturing knowledge integration through collaborations: measures of the diversity and coherence in multiple proximity dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Lang, F.; Rafols, I.; Hopkins, M.

    2016-07-01

    This paper proposes a novel approach to determine changes that occur as a result of collaborations that is intended to support knowledge integration. The approach combines and applies indicators of proximity, diversity, coherence and has potential applications in the study and evaluation of research collaborations. The scientometric literature has been exploring the topic of knowledge integration and interdisciplinarity for more than a decade (Bordons, 2004; Zitt, 2005; Rafols, 2014). The paper builds on the line of research that seeks to develop measures of knowledge integration, namely diversity and coherence (Rafols, 2014). Successful exchange and integration of knowledge through collaboration not only requires disciplinary or cognitive diversity, as previously studied in the scientometric literature (Rafols & Meyer, 2009; Rafols, 2014) but also other dimensions linked to the social, cultural background of the individuals involved. Economic geographers have developed a framework, the proximity framework (Boschma, 2005), identifying five features that may be important for collaborative learning which are: cognitive, social, geographical, institutional, and organisational proximities. The paper therefore proposes to use the diversity and coherence measures to not only look at diversity from a cognitive standpoint, but also apply it to the other proximities proposed in the Boschma framework. These indicators will capture the relationship occurring betweenindividuals taking part in the research and the categories (proximity dimensions) that they are associated to. This paper reviews and integrates concepts from economic geography with the scientometric literature on interdisciplinarity to form a conceptual framework that the paper applies to an illustrative case study. In order to apply the framework, the paper develops indicators for diversity and coherence that can be applied to each of Boschma’s five proximities. The illustrative case study looks at

  12. Congenital anomalies and proximity to landfill sites.

    LENUS (Irish Health Repository)

    Boyle, E

    2004-01-01

    The occurrence of congenital anomalies in proximity to municipal landfill sites in the Eastern Region (counties Dublin, Kildare, Wicklow) was examined by small area (district electoral division), distance and clustering tendancies in relation to 83 landfills, five of which were major sites. The study included 2136 cases of congenital anomaly, 37,487 births and 1423 controls between 1986 and 1990. For the more populous areas of the region 50% of the population lived within 2-3 km of a landfill and within 4-5 km for more rural areas. In the area-level analysis, the standardised prevalence ratios, empirical and full Bayesian modelling, and Kulldorff\\'s spatial scan statistic found no association between the residential area of cases and location of landfills. In the case control analysis, the mean distance of cases and controls from the nearest landfill was similar. The odds ratios of cases compared to controls for increasing distances from all landfills and major landfills showed no significant difference from the baseline value of 1. The kernel and K methods showed no tendency of cases to cluster in relationship to landfills. In conclusion, congenital anomalies were not found to occur more commonly in proximity to municipal landfills.

  13. Obesity and supermarket access: proximity or price?

    Science.gov (United States)

    Drewnowski, Adam; Aggarwal, Anju; Hurvitz, Philip M; Monsivais, Pablo; Moudon, Anne V

    2012-08-01

    We examined whether physical proximity to supermarkets or supermarket price was more strongly associated with obesity risk. The Seattle Obesity Study (SOS) collected and geocoded data on home addresses and food shopping destinations for a representative sample of adult residents of King County, Washington. Supermarkets were stratified into 3 price levels based on average cost of the market basket. Sociodemographic and health data were obtained from a telephone survey. Modified Poisson regression was used to test the associations between obesity and supermarket variables. Only 1 in 7 respondents reported shopping at the nearest supermarket. The risk of obesity was not associated with street network distances between home and the nearest supermarket or the supermarket that SOS participants reported as their primary food source. The type of supermarket, by price, was found to be inversely and significantly associated with obesity rates, even after adjusting for individual-level sociodemographic and lifestyle variables, and proximity measures (adjusted relative risk=0.34; 95% confidence interval=0.19, 0.63) Improving physical access to supermarkets may be one strategy to deal with the obesity epidemic; improving economic access to healthy foods is another.

  14. Proximal Tubular Cannabinoid-1 Receptor Regulates Obesity-Induced CKD.

    Science.gov (United States)

    Udi, Shiran; Hinden, Liad; Earley, Brian; Drori, Adi; Reuveni, Noa; Hadar, Rivka; Cinar, Resat; Nemirovski, Alina; Tam, Joseph

    2017-12-01

    Obesity-related structural and functional changes in the kidney develop early in the course of obesity and occur independently of hypertension, diabetes, and dyslipidemia. Activating the renal cannabinoid-1 receptor (CB 1 R) induces nephropathy, whereas CB 1 R blockade improves kidney function. Whether these effects are mediated via a specific cell type within the kidney remains unknown. Here, we show that specific deletion of CB 1 R in the renal proximal tubule cells did not protect the mice from obesity, but markedly attenuated the obesity-induced lipid accumulation in the kidney and renal dysfunction, injury, inflammation, and fibrosis. These effects associated with increased activation of liver kinase B1 and the energy sensor AMP-activated protein kinase, as well as enhanced fatty acid β -oxidation. Collectively, these findings indicate that renal proximal tubule cell CB 1 R contributes to the pathogenesis of obesity-induced renal lipotoxicity and nephropathy by regulating the liver kinase B1/AMP-activated protein kinase signaling pathway. Copyright © 2017 by the American Society of Nephrology.

  15. Method to Measure Tone of Axial and Proximal Muscle

    Science.gov (United States)

    Gurfinkel, Victor S.; Cacciatore, Timothy W.; Cordo, Paul J.; Horak, Fay B.

    2011-01-01

    The control of tonic muscular activity remains poorly understood. While abnormal tone is commonly assessed clinically by measuring the passive resistance of relaxed limbs1, no systems are available to study tonic muscle control in a natural, active state of antigravity support. We have developed a device (Twister) to study tonic regulation of axial and proximal muscles during active postural maintenance (i.e. postural tone). Twister rotates axial body regions relative to each other about the vertical axis during stance, so as to twist the neck, trunk or hip regions. This twisting imposes length changes on axial muscles without changing the body's relationship to gravity. Because Twister does not provide postural support, tone must be regulated to counteract gravitational torques. We quantify this tonic regulation by the restive torque to twisting, which reflects the state of all muscles undergoing length changes, as well as by electromyography of relevant muscles. Because tone is characterized by long-lasting low-level muscle activity, tonic control is studied with slow movements that produce "tonic" changes in muscle length, without evoking fast "phasic" responses. Twister can be reconfigured to study various aspects of muscle tone, such as co-contraction, tonic modulation to postural changes, tonic interactions across body segments, as well as perceptual thresholds to slow axial rotation. Twister can also be used to provide a quantitative measurement of the effects of disease on axial and proximal postural tone and assess the efficacy of intervention. PMID:22214974

  16. Parkinson's Disease Prevalence and Proximity to Agricultural Cultivated Fields

    Science.gov (United States)

    Yitshak Sade, Maayan; Zlotnik, Yair; Kloog, Itai; Novack, Victor; Peretz, Chava; Ifergane, Gal

    2015-01-01

    The risk for developing Parkinson's disease (PD) is a combination of multiple environmental and genetic factors. The Negev (Southern Israel) contains approximately 252.5 km2 of agricultural cultivated fields (ACF). We aimed to estimate the prevalence and incidence of PD and to examine possible geographical clustering and associations with agricultural exposures. We screened all “Clalit” Health Services members in the Negev (70% of the population) between the years 2000 and 2012. Individual demographic, clinical, and medication prescription data were available. We used a refined medication tracer algorithm to identify PD patients. We used mixed Poisson models to calculate the smoothed standardized incidence rates (SIRs) for each locality. We identified ACF and calculate the size and distance of the fields from each locality. We identified 3,792 cases of PD. SIRs were higher than expected in Jewish rural localities (median SIR [95% CI]: 1.41 [1.28; 1.53] in 2001–2004, 1.62 [1.48; 1.76] in 2005–2008, and 1.57 [1.44; 1.80] in 2009–2012). Highest SIR was observed in localities located in proximity to large ACF (SIR 1.54, 95% CI 1.32; 1.79). In conclusion, in this population based study we found that PD SIRs were higher than expected in rural localities. Furthermore, it appears that proximity to ACF and the field size contribute to PD risk. PMID:26357584

  17. Optimal proximity correction: application for flash memory design

    Science.gov (United States)

    Chen, Y. O.; Huang, D. L.; Sung, K. T.; Chiang, J. J.; Yu, M.; Teng, F.; Chu, Lung; Rey, Juan C.; Bernard, Douglas A.; Li, Jiangwei; Li, Junling; Moroz, V.; Boksha, Victor V.

    1998-06-01

    Proximity Correction is the technology for which the most of IC manufacturers are committed already. The final intended result of correction is affected by many factors other than the optical characteristics of the mask-stepper system, such as photoresist exposure, post-exposure bake and development parameters, etch selectivity and anisotropy, and underlying topography. The most advanced industry and research groups already reported immediate need to consider wafer topography as one of the major components during a Proximity Correction procedure. In the present work we are discussing the corners rounding effect (which eventually cause electrical leakage) observed for the elements of Poly2 layer for a Flash Memory Design. It was found that the rounding originated by three- dimensional effects due to variation of photoresist thickness resulting from the non-planar substrate. Our major goal was to understand the reasons and correct corner rounding. As a result of this work highly effective layout correction methodology was demonstrated and manufacturable Depth Of Focus was achieved. Another purpose of the work was to demonstrate complete integration flow for a Flash Memory Design based on photolithography; deposition/etch; ion implantation/oxidation/diffusion; and device simulators.

  18. Proximal Tubule Cell Hypothesis for Cardiorenal Syndrome in Diabetes

    Directory of Open Access Journals (Sweden)

    Akihiko Saito

    2011-01-01

    Full Text Available Incidence of cardiovascular disease (CVD is remarkably high among patients with chronic kidney disease (CKD, even in the early microalbuminuric stages with normal glomerular filtration rates. Proximal tubule cells (PTCs mediate metabolism and urinary excretion of vasculotoxic substances via apical and basolateral receptors and transporters. These cells also retrieve vasculoprotective substances from circulation or synthesize them for release into the circulation. PTCs are also involved in the uptake of sodium and phosphate, which are critical for hemodynamic regulation and maintaining the mineral balance, respectively. Dysregulation of PTC functions in CKD is likely to be associated with the development of CVD and is linked to the progression to end-stage renal disease. In particular, PTC dysfunction occurs early in diabetic nephropathy, a leading cause of CKD. It is therefore important to elucidate the mechanisms of PTC dysfunction to develop therapeutic strategies for treating cardiorenal syndrome in diabetes.

  19. Posttraumatic Proximal Radioulnar Synostosis after Closed Reduction for a Radial Neck and Olecranon Fracture

    Directory of Open Access Journals (Sweden)

    Patrick R. Keller

    2018-01-01

    Full Text Available Posttraumatic proximal radioulnar synostosis (PPRUS is a severe complication of radial head and neck fractures known to occur after severe injury or operative fixation. Cases of PPRUS occurring after minimally displaced, nonoperatively treated radial neck injuries are, by contrast, extremely rare. Here, we present a pediatric case of PPRUS that developed after a nonoperatively treated minimally displaced radial neck fracture with concomitant olecranon fracture. While more cases are needed to establish the association between this pattern of injury and PPRUS, we recommend that when encountering patients with a minimally displaced radial neck fracture and a concomitant elbow injury, the rare possibility of developing proximal radioulnar synostosis should be considered.

  20. Promoter proximal polyadenylation sites reduce transcription activity

    DEFF Research Database (Denmark)

    Andersen, Pia Kjølhede; Lykke-Andersen, Søren; Jensen, Torben Heick

    2012-01-01

    Gene expression relies on the functional communication between mRNA processing and transcription. We previously described the negative impact of a point-mutated splice donor (SD) site on transcription. Here we demonstrate that this mutation activates an upstream cryptic polyadenylation (CpA) site......, which in turn causes reduced transcription. Functional depletion of U1 snRNP in the context of the wild-type SD triggers the same CpA event accompanied by decreased RNA levels. Thus, in accordance with recent findings, U1 snRNP can shield premature pA sites. The negative impact of unshielded pA sites...... on transcription requires promoter proximity, as demonstrated using artificial constructs and supported by a genome-wide data set. Importantly, transcription down-regulation can be recapitulated in a gene context devoid of splice sites by placing a functional bona fide pA site/transcription terminator within ∼500...

  1. RBPJ is disrupted in a case of proximal 4p deletion syndrome with epilepsy.

    Science.gov (United States)

    Nakayama, Tojo; Saitsu, Hirotomo; Endo, Wakaba; Kikuchi, Atsuo; Uematsu, Mitsugu; Haginoya, Kazuhiro; Hino-fukuyo, Naomi; Kobayashi, Tomoko; Iwasaki, Masaki; Tominaga, Teiji; Kure, Shigeo; Matsumoto, Naomichi

    2014-06-01

    Proximal 4p deletion syndrome is characterized clinically by mental retardation, minor dysmorphic facial features, and is occasionally complicated with epilepsy. More than 20 cases of proximal 4p deletion syndrome have been reported, but the causative gene(s) remain elusive. We describe here a 2-year-old female patient with a common manifestation of proximal 4p deletion syndrome and infantile epileptic encephalopathy possessing a de novo balanced translocation t(4;13)(p15.2;q12.13). The patient was diagnosed as infantile spasms at 9 months of age. She presented with dysmorphic facial features and global developmental delay, compatible with proximal 4p deletion syndrome. Using fluorescence in situ hybridization, we determined the translocation breakpoint at 4p15.2 to be within RBPJ. RBPJ is a transcription factor in the Notch/RBPJ signaling pathway, playing a crucial role in the developing human brain, and particularly telencephalon development. Our findings, combined with those of previous studies, strongly suggest that RBPJ is causative for proximal 4p deletion syndrome and epilepsy in this case. Copyright © 2013 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

  2. Proximity Online Media in Catalonia (Spain. The Case Study of Nació Digital Group

    Directory of Open Access Journals (Sweden)

    Mònica Puntí Brun

    2015-04-01

    Full Text Available This paper aims to make a conceptualization of proximity digital media. It will define what is local and proximity communication as well as the history and evolution of online journalism and digital media features which are briefly reviewed. Business models that exist nowadays and the state of art in Catalonia (Spain will also be briefly analysed. From this theoretical framework it will be explained the case of Nació Digital and its territorial media. Initially the history of this media group will be developed, as well as its journalistic and business models. The paper seeks to underscore the importance of the journalistic model based on the tradition of the profession, the proximity information and the technology developed for this online media. The Nació Digital is an example of a successful media outlet judging from its audience figures (the second online media in Catalonia and its sustainable model business.

  3. A flexible dual-mode proximity sensor based on cooperative sensing for robot skin applications

    Science.gov (United States)

    Huang, Ying; Cai, Xia; Kan, Wenqing; Qiu, Shihua; Guo, Xiaohui; Liu, Caixia; Liu, Ping

    2017-08-01

    A flexible dual-mode proximity sensor has been designed and implemented, which is capable of combining capacitive-resistive detection in this paper. The capacitive type proximity sensor detecting is defined as mode-C, and the resistive type proximity sensor detecting is defined as mode-R. The characteristics of the proximity sensor are as follows: (1) the theoretical mode is developed which indicates that this proximity sensor can reflect proximity information accurately; (2) both sensing modes are vertically integrated into a sandwich-like chip with an 8 mm × 12 mm unit area. The thickness of a mode-R sensing material (graphene nanoplatelets) and mode-C dielectric (the mixture of carbon black and silicone rubber) is 1 mm and 2.5 mm, respectively; (3) for mode-R, the linearity of temperature-resistance curve can achieve 0.998 in the temperature range from 25°C to 65°C. And for mode-C, various materials can be successfully detected with fast response and high reversibility. Meanwhile, the study compensated the influence of object temperature to ensure mode-C properly works. A cooperative sensing test shows that R-C dual modes sense effectively which can enlarge the sensing distance compared with the single mode proximity sensor. The fabrication of this sensor is convenient, and the integrity of a flexible sandwich-like structure based on dual modes is beneficial to form arrays, which is suitable to be used in skin-like sensing applications.

  4. Phase holograms in PMMA with proximity effect correction

    Science.gov (United States)

    Maker, Paul D.; Muller, R. E.

    1993-01-01

    Complex computer generated phase holograms (CGPH's) have been fabricated in PMMA by partial e-beam exposure and subsequent partial development. The CGPH was encoded as a sequence of phase delay pixels and written by the JEOL JBX-5D2 E-beam lithography system, a different dose being assigned to each value of phase delay. Following carefully controlled partial development, the pattern appeared rendered in relief in the PMMA, which then acts as the phase-delay medium. The exposure dose was in the range 20-200 micro-C/sq cm, and very aggressive development in pure acetone led to low contrast. This enabled etch depth control to better than plus or minus lambda(sub vis)/60. That result was obtained by exposing isolated 50 micron square patches and measuring resist removal over the central area where the proximity effect dose was uniform and related only to the local exposure. For complex CGPH's with pixel size of the order of the e-beam proximity effect radius, the patterns must be corrected for the extra exposure caused by electrons scattered back up out of the substrate. This has been accomplished by deconvolving the two-dimensional dose deposition function with the desired dose pattern. The deposition function, which plays much the same role as an instrument response function, was carefully measured under the exact conditions used to expose the samples. The devices fabricated were designed with 16 equal phase steps per retardation cycle, were up to 1 cm square, and consisted of up to 100 million 0.3-2.0 micron square pixels. Data files were up to 500 MB long and exposure times ranged to tens of hours. A Fresnel phase lens was fabricated that had diffraction limited optical performance with better than 85 percent efficiency.

  5. PROXIMAL DISABILITY AND SPINAL DEFORMITY INDEX IN PATIENTS WITH PROXIMAL FEMUR FRACTURES

    Directory of Open Access Journals (Sweden)

    Sylvio Mistro Neto

    2015-12-01

    Full Text Available Objective : To evaluate the quality of life related to the spine in patients with proximal femoral fractures. Methods : Study conducted in a tertiary public hospital in patients with proximal femoral fractures caused by low-energy trauma, through the Oswestry Disability Index questionnaire to asses complaints related to the spine at the time of life prior to the femoral fracture. The thoracic and lumbar spine of patients were also evaluated applying the radiographic index described by Gennant (Spinal Deformity Index, which assesses the number and severity of fractures. Results : Seventeen subjects completed the study. All had some degree of vertebral fracture. Patients were classified in the categories of severe and very severe disability in the questionnaire about quality of life. It was found that the higher SDI, the better the quality of life. Conclusion : There is a strong association of disability related to the spine in patients with proximal femoral fracture, and this complaint must be systematically evaluated in patients with appendicular fracture.

  6. Initial outcome and efficacy of S3 proximal humerus locking plate in the treatment of proximal humerus fractures

    International Nuclear Information System (INIS)

    Zhang Zhiming; Zhu Xuesong; Bao Zhaohua; Yang Huilin

    2012-01-01

    Objective: to explore the initial outcome and efficacy of S 3 proximal humerus locking plate in the treatment of proximal humerus fractures. Methods: Twenty-two patients with proximal humerus fracture were treated with the S 3 proximal humerus locking plate. Most of the fractures were complex, two-part (n=4), three-part (n=11) and four-part (n=7) fractures according to the Neer classification of the proximal humerus fractures. Results: All patients were followed up for 3∼15 months. There were no complications related to the implant including loosening or breakage of the plate. Good and excellent results were documented in 17 patients fair results in 4 patients according the Neer scores of shoulder. Conclusion: New design concepts of S 3 proximal humerus plate provide the subchondral support and the internal fixation support. With the addition of the proper exercise of the shoulder joint, the outcomes would be satisfied. (authors)

  7. An efficient dose-compensation method for proximity effect correction

    International Nuclear Information System (INIS)

    Wang Ying; Han Weihua; Yang Xiang; Zhang Yang; Yang Fuhua; Zhang Renping

    2010-01-01

    A novel simple dose-compensation method is developed for proximity effect correction in electron-beam lithography. The sizes of exposed patterns depend on dose factors while other exposure parameters (including accelerate voltage, resist thickness, exposing step size, substrate material, and so on) remain constant. This method is based on two reasonable assumptions in the evaluation of the compensated dose factor: one is that the relation between dose factors and circle-diameters is linear in the range under consideration; the other is that the compensated dose factor is only affected by the nearest neighbors for simplicity. Four-layer-hexagon photonic crystal structures were fabricated as test patterns to demonstrate this method. Compared to the uncorrected structures, the homogeneity of the corrected hole-size in photonic crystal structures was clearly improved. (semiconductor technology)

  8. Proximal duodenal perforation in three dogs following deracoxib administration.

    Science.gov (United States)

    Case, J Brad; Fick, Jennifer L; Rooney, Matthew B

    2010-01-01

    The purpose of this study was to describe the clinical and gross pathological findings, treatment, and outcome in three dogs receiving deracoxib that developed proximal duodenal perforation and subsequent septic peritonitis. Clinical findings were acute vomiting and anorexia following initiation of deracoxib therapy. Deracoxib dosages ranged from 2 to 3 mg/kg per os q 24 hours. In each dog, exploratory laparotomy revealed duodenal perforations approximately 1 cm orad to the major duodenal papilla. Two out of three dogs survived following exploratory laparotomy. Two of three dogs in the present case series received the approved deracoxib dosage. Dogs receiving deracoxib, even at labeled dosages, should be monitored judiciously for signs of gastrointestinal disease.

  9. Rendezvous, proximity operations and capture quality function deployment report

    Science.gov (United States)

    Lamkin, Stephen L. (Editor)

    1991-01-01

    Rendezvous, Proximity Operations, and Capture (RPOC) is a missions operations area which is extremely important to present and future space initiatives and must be well planned and coordinated. To support this, a study team was formed to identify a specific plan of action using the Quality Function Deployment (QFD) process. This team was composed of members from a wide spectrum of engineering and operations organizations which are involved in the RPOC technology area. The key to this study's success is an understanding of the needs of potential programmatic customers and the technology base available for system implementation. To this end, the study team conducted interviews with a variety of near term and future programmatic customers and technology development sponsors. The QFD activity led to a thorough understanding of the needs of these customers in the RPOC area, as well as the relative importance of these needs.

  10. Rendezvous, proximity operations and capture quality function deployment report

    Science.gov (United States)

    Lamkin, Stephen L.

    1991-12-01

    Rendezvous, Proximity Operations, and Capture (RPOC) is a missions operations area which is extremely important to present and future space initiatives and must be well planned and coordinated. To support this, a study team was formed to identify a specific plan of action using the Quality Function Deployment (QFD) process. This team was composed of members from a wide spectrum of engineering and operations organizations which are involved in the RPOC technology area. The key to this study's success is an understanding of the needs of potential programmatic customers and the technology base available for system implementation. To this end, the study team conducted interviews with a variety of near term and future programmatic customers and technology development sponsors. The QFD activity led to a thorough understanding of the needs of these customers in the RPOC area, as well as the relative importance of these needs.

  11. Biomechanical Evaluation of Standard Versus Extended Proximal Fixation Olecranon Plates for Fixation of Olecranon Fractures.

    Science.gov (United States)

    Boden, Allison L; Daly, Charles A; Dalwadi, Poonam P; Boden, Stephanie A; Hutton, William C; Muppavarapu, Raghuveer C; Gottschalk, Michael B

    2018-01-01

    Small olecranon fractures present a significant challenge for fixation, which has resulted in development of plates with proximal extension. Olecranon-specific plates with proximal extensions are widely thought to offer superior fixation of small proximal fragments but have distinct disadvantages: larger dissection, increased hardware prominence, and the increased possibility of impingement. Previous biomechanical studies of olecranon fracture fixation have compared methods of fracture fixation, but to date there have been no studies defining olecranon plate fixation strength for standard versus extended olecranon plates. The purpose of this study is to evaluate the biomechanical utility of the extended plate for treatment of olecranon fractures. Sixteen matched pairs of fresh-frozen human cadaveric elbows were used. Of the 16, 8 matched pairs received a transverse osteotomy including 25% and 8 including 50% of the articular surface on the proximal fragment. One elbow from each pair was randomly assigned to a standard-length plate, and the other elbow in the pair received the extended-length plate, for fixation of the fracture. The ulnae were cyclically loaded and subsequently loaded to failure, with ultimate load, number of cycles, and gap formation recorded. There was no statistically significant difference between the standard and extended fixation plates in simple transverse fractures at either 25% or 50% from the proximal most portion of the articular surface of the olecranon. Standard fixation plates are sufficient for the fixation of small transverse fractures, but caution should be utilized particularly with comminution and nontransverse fracture patterns.

  12. Constructing the vanishing present between the future and the past

    DEFF Research Database (Denmark)

    Valsiner, Jaan

    2011-01-01

    Development is a process of creating actual time-course of movement out of possible ones—both of the future and of the past. This focus was central for the original notion of “zone of proximal development' (ZPD—Vygotsky)—yet it has not been developed further since 1930s. Human beings operate in-b...

  13. Medieval and early modern approaches to fractures of the proximal humerus

    DEFF Research Database (Denmark)

    Brorson, S.

    2010-01-01

    The diagnosis and management of complex fractures of the proximal humerus have challenged surgical practitioners and medical writers since the earliest recorded surgical texts. Current knowledge of fractures of the proximal humerus has been obtained through pathoanatomical and biomechanical studies...... within the last two centuries. However, the historical preconditions for this development have not been studied. This paper reviews written sources from the fall of the Roman Empire to the late eighteenth century. Medieval and early modern writers mainly rely on the Hippocratic writings De Fracturis...

  14. Medieval and early modern approaches to fractures of the proximal humerus: an historical review

    DEFF Research Database (Denmark)

    Brorson, S.

    2010-01-01

    The diagnosis and management of complex fractures of the proximal humerus have challenged surgical practitioners and medical writers since the earliest recorded surgical texts. Current knowledge of fractures of the proximal humerus has been obtained through pathoanatomical and biomechanical studies...... within the last two centuries. However, the historical preconditions for this development have not been studied. This paper reviews written sources from the fall of the Roman Empire to the late eighteenth century. Medieval and early modern writers mainly rely on the Hippocratic writings De Fracturis...

  15. Endoscopic removal of a proximal urethral stent using a holmium laser: Case report and literature review

    Directory of Open Access Journals (Sweden)

    Francisco Botelho

    2012-01-01

    Full Text Available Urethral stents were initially developed for the management of urethral strictures and obstructive voiding disorders in select patients. Urethral stent complications are common and may require stent explantation, which is often quite challenging. We present our experience with endoscopic removal of an encrusted UroLume proximal urethral stent in a 72-year-old male using a holmium laser. The literature on various management options and outcomes for urethral stent removal is reviewed. Endoscopic removal of proximal urethral stents is feasible and safe and should be considered as the primary treatment option in patients requiring stent extraction.

  16. The Rendezvous Monitoring Display Capabilities of the Rendezvous and Proximity Operations Program

    Science.gov (United States)

    Brazzel, Jack; Spehar, Pete; Clark, Fred; Foster, Chris; Eldridge, Erin

    2013-01-01

    The Rendezvous and Proximity Operations Program (RPOP) is a laptop computer- based relative navigation tool and piloting aid that was developed during the Space Shuttle program. RPOP displays a graphical representation of the relative motion between the target and chaser vehicles in a rendezvous, proximity operations and capture scenario. After being used in over 60 Shuttle rendezvous missions, some of the RPOP display concepts have become recognized as a minimum standard for cockpit displays for monitoring the rendezvous task. To support International Space Station (ISS) based crews in monitoring incoming visiting vehicles, RPOP has been modified to allow crews to compare the Cygnus visiting vehicle s onboard navigated state to processed range measurements from an ISS-based, crew-operated Hand Held Lidar sensor. This paper will discuss the display concepts of RPOP that have proven useful in performing and monitoring rendezvous and proximity operations.

  17. Treatment of humeroulnar subluxation with a dynamic proximal ulnar osteotomy: a review of 13 cases

    International Nuclear Information System (INIS)

    Gilson, S.D.; Piermattei, D.L.; Schwarz, P.D.

    1989-01-01

    Humeroulnar subluxation was treated surgically in 13 dogs with 18 affected elbows using a proximal osteotomy of the ulna that allowed the ulna to elongate dynamically. Distal humeroulnar subluxation was secondary to premature closure of the distal ulnar physis in 16 elbows. One distal subluxation was secondary to a radioulnar synostosis, and one proximal subluxation developed after premature closure of the distal radial physis. The mean follow-up time was 22 months. Twenty-eight percent of the elbows were judged to have excellent results, 22% good results, 50% fair results, and none was judged to have a poor outcome. The presenting lameness grade and the severity of preoperative and postoperative humeroulnar subluxation had significant correlations with the prognosis. Associated orthopedic abnormalities and complications of concurrent surgical procedures affected the outcome in several dogs. Overall, the dynamic proximal ulnar osteotomy was a simple and effective technique for the treatment of uncomplicated humeroulnar subluxation

  18. Clinical cavitation and radiographic lesion depth in proximal surfaces in an Indian population

    DEFF Research Database (Denmark)

    Sansare, Kaustubh; Raghav, Mamta; Sontakke, Subodeh

    2014-01-01

    the developing world. Materials and methods. Relationship between clinical cavitation and radiographic caries lesion depth in proximal surfaces in an Indian population was assessed. Proximal surfaces (n = 126) without restorations were examined on bitewing radiographs in patients with suspected caries and lesion......Abstract Objectives. To assess the relationship between clinical cavitation and radiographic caries lesion depth in proximal surfaces of permanent posterior teeth in an Indian population. This study also assessed the clinical feasibility of applying 'western guidelines' to this population from...... to the radiographic findings of lesion depth, 80-100% of the lesions observed in outer dentine would lead to a false (non-operative) treatment decision. Conclusions. Radiographic shallow carious lesions were often cavitated in this population. The threshold for cavitation in this study population is suggested...

  19. Semiconductor detectors with proximity signal readout

    International Nuclear Information System (INIS)

    Asztalos, Stephen J.

    2012-01-01

    Semiconductor-based radiation detectors are routinely used for the detection, imaging, and spectroscopy of x-rays, gamma rays, and charged particles for applications in the areas of nuclear and medical physics, astrophysics, environmental remediation, nuclear nonproliferation, and homeland security. Detectors used for imaging and particle tracking are more complex in that they typically must also measure the location of the radiation interaction in addition to the deposited energy. In such detectors, the position measurement is often achieved by dividing or segmenting the electrodes into many strips or pixels and then reading out the signals from all of the electrode segments. Fine electrode segmentation is problematic for many of the standard semiconductor detector technologies. Clearly there is a need for a semiconductor-based radiation detector technology that can achieve fine position resolution while maintaining the excellent energy resolution intrinsic to semiconductor detectors, can be fabricated through simple processes, does not require complex electrical interconnections to the detector, and can reduce the number of required channels of readout electronics. Proximity electrode signal readout (PESR), in which the electrodes are not in physical contact with the detector surface, satisfies this need

  20. Imaging of rectus femoris proximal tendinopathies

    International Nuclear Information System (INIS)

    Pesquer, Lionel; Poussange, Nicolas; Meyer, Philippe; Dallaudiere, Benjamin; Feldis, Matthieu; Sonnery-Cottet, Bertrand; Graveleau, Nicolas

    2016-01-01

    The rectus femoris is the most commonly injured muscle of the anterior thigh among athletes, especially soccer players. Although the injury pattern of the muscle belly is well documented, less is known about the anatomy and specific lesions of the proximal tendons. For each head, three distinctive patterns may be encountered according to the location of the injury, which can be at the enthesis, within the tendon, or at the musculotendinous junction. In children, injuries correspond most commonly to avulsion of the anteroinferior iliac spine from the direct head and can lead to subspine impingement. Calcific tendinitis and traumatic tears may be encountered in adults. Recent studies have shown that traumatic injuries of the indirect head may be underdiagnosed and that injuries of both heads may have a surgical issue. Finally, in the case of tears, functional outcome and treatment may vary if the rupture involves one or both tendons and if the tear is partial or complete. Thus, it is mandatory for the radiologist to know the different ultrasound and magnetic resonance imaging (MRI) patterns of these lesions in order to provide accurate diagnosis and treatment. The purpose of this article is to recall the anatomy of the two heads of rectus femoris, describe a reliable method of assessment with ultrasound and MRI and know the main injury patterns, through our own experience and literature review. (orig.)

  1. Proximal spinal muscular atrophy: current orthopedic perspective

    Directory of Open Access Journals (Sweden)

    Haaker G

    2013-11-01

    Full Text Available Gerrit Haaker, Albert Fujak Department of Orthopaedic Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany Abstract: Spinal muscular atrophy (SMA is a hereditary neuromuscular disease of lower motor neurons that is caused by a defective "survival motor neuron" (SMN protein that is mainly associated with proximal progressive muscle weakness and atrophy. Although SMA involves a wide range of disease severity and a high mortality and morbidity rate, recent advances in multidisciplinary supportive care have enhanced quality of life and life expectancy. Active research for possible treatment options has become possible since the disease-causing gene defect was identified in 1995. Nevertheless, a causal therapy is not available at present, and therapeutic management of SMA remains challenging; the prolonged survival is increasing, especially orthopedic, respiratory and nutritive problems. This review focuses on orthopedic management of the disease, with discussion of key aspects that include scoliosis, muscular contractures, hip joint disorders, fractures, technical devices, and a comparative approach of conservative and surgical treatment. Also emphasized are associated complications including respiratory involvement, perioperative care and anesthesia, nutrition problems, and rehabilitation. The SMA disease course can be greatly improved with adequate therapy with established orthopedic procedures in a multidisciplinary therapeutic approach. Keywords: spinal muscular atrophy, scoliosis, contractures, fractures, lung function, treatment, rehabilitation, surgery, ventilation, nutrition, perioperative management

  2. Imaging of rectus femoris proximal tendinopathies

    Energy Technology Data Exchange (ETDEWEB)

    Pesquer, Lionel; Poussange, Nicolas; Meyer, Philippe; Dallaudiere, Benjamin; Feldis, Matthieu [Clinique du Sport de Bordeaux, Centre d' Imagerie Osteo-articulaire, Merignac (France); Sonnery-Cottet, Bertrand [Groupe Ramsay Generale de Sante - Hopital Prive Jean Mermoz, Centre Orthopedique Santy, Lyon (France); Graveleau, Nicolas [Clinique du Sport de Bordeaux, Centre de Chirurgie Orthopedique et Sportive, Merignac (France)

    2016-07-15

    The rectus femoris is the most commonly injured muscle of the anterior thigh among athletes, especially soccer players. Although the injury pattern of the muscle belly is well documented, less is known about the anatomy and specific lesions of the proximal tendons. For each head, three distinctive patterns may be encountered according to the location of the injury, which can be at the enthesis, within the tendon, or at the musculotendinous junction. In children, injuries correspond most commonly to avulsion of the anteroinferior iliac spine from the direct head and can lead to subspine impingement. Calcific tendinitis and traumatic tears may be encountered in adults. Recent studies have shown that traumatic injuries of the indirect head may be underdiagnosed and that injuries of both heads may have a surgical issue. Finally, in the case of tears, functional outcome and treatment may vary if the rupture involves one or both tendons and if the tear is partial or complete. Thus, it is mandatory for the radiologist to know the different ultrasound and magnetic resonance imaging (MRI) patterns of these lesions in order to provide accurate diagnosis and treatment. The purpose of this article is to recall the anatomy of the two heads of rectus femoris, describe a reliable method of assessment with ultrasound and MRI and know the main injury patterns, through our own experience and literature review. (orig.)

  3. Acute proximal junctional failure in patients with preoperative sagittal imbalance.

    Science.gov (United States)

    Smith, Micah W; Annis, Prokopis; Lawrence, Brandon D; Daubs, Michael D; Brodke, Darrel S

    2015-10-01

    Proximal junctional failure (PJF) is a recognized complication of spinal deformity surgery. Acute PJF (APJF) has recently been demonstrated to be 5.6% in the adult spinal deformity (ASD) population. The incidence and rate of return to the operating room for APJF have not been specifically investigated in individuals with sagittal imbalance. The purpose of this study was to report the incidence of APJF in patients with preoperative sagittal imbalance and the rate of return to the operating room for APJF. This study is based on a retrospective review of prospectively collected database of ASD patients. One hundred seventy-three consecutive patients were included with preoperative sagittal imbalance according to one of the following common parameters: sagittal vertical axis (SVA) greater than 50 mm, global sagittal alignment greater than 45°, or pelvic incidence minus lumbar lordosis greater than 10°. Outcome measure was presence and/or absence of APJF defined as fracture at the upper instrumented vertebra (UIV) or UIV+1, failure of UIV fixation, 15° or more proximal junctional kyphosis, or need for extension of instrumentation within 6 months of surgery. We performed radiographic measurements on X-rays at preoperative, immediate postoperative, and 6-month follow-up visits. The APJF rate was reported for the entire patient population with preoperative sagittal imbalance. Acute PJF incidence was calculated postoperatively for each of the accepted sagittal balance parameters and/or formulas. Patients with persistent postoperative sagittal imbalance were compared with the sagittally balanced group. We also assessed for threshold values. Acute PJF was observed in 60 of 173 patients (35%) and was least common in fusions with the UIV in the upper thoracic (UT) spine (p=.035). Of those who developed APJF, 21.7% required surgery. Proximal junctional kyphosis 15° or more was the most common form of APJF in fusions to the UT spine but least likely to need revision (p=.014

  4. High-Tc SNS Junctions: A New Generation of Proximity-Coupled Josephson Devices

    Science.gov (United States)

    Kleinsasser, A. W.

    1997-01-01

    This paper reviews this evolution of proximity - coupled Josephson jucntion from the early investigations on low temperature superconductor-normal -superconductor junctions through the introduction of hybrid superconductor-semiconductor devices and the resulting interest in mesoscopic Josephson junctions, to the recent development of high temperature devices.

  5. Oxygenation and EMG in the proximal and distal vastus lateralis during submaximal isometric knee extension

    DEFF Research Database (Denmark)

    Crenshaw, Albert G.; Bronee, Lars; Krag, Ida

    2010-01-01

    /or (2) fatigue development. Nine males performed 2-min sustained isometric knee extensions at 15% and 30% maximum voluntary contraction during which oxygenation and EMG were recorded simultaneously from proximal and distal locations of the vastus lateralis muscle. Near infrared spectroscopy variables...

  6. Innovation, networking, and proximity: lessons from small high-technology firms in the UK

    NARCIS (Netherlands)

    Romijn, H.A.; Albu, Mike

    2002-01-01

    The article explores how the innovative performance of small high-tech firms relates to their external networking activities, and whether geographical proximity in their network relations matters. Data from a small sample of electronics firms and software developers in South East England are used to

  7. The zone of proximal development in the learning of mathematics ...

    African Journals Online (AJOL)

    South Africa has a huge shortage of skilled workers in various fields such as engineering, applied sciences, accountancy, architecture, medicine and law. Mathematics is a requirement for entry in these careers to enable learners to grasp the content of various subjects in these disciplines. Despite that, in South Africa, ...

  8. The Zone of Proximal Development in the Learning of Mathematics

    Science.gov (United States)

    Siyepu, Sibawu

    2013-01-01

    South Africa has a huge shortage of skilled workers in various fields such as engineering, applied sciences, accountancy, architecture, medicine and law. Mathematics is a requirement for entry in these careers to enable learners to grasp the content of various subjects in these disciplines. Despite that, in South Africa, learners' performance in…

  9. Proximate analysis of female population of wild feather back fish ...

    African Journals Online (AJOL)

    User

    2011-05-09

    May 9, 2011 ... Key words: Body composition, Notopterus notopterus, condition factor, wild fish. INTRODUCTION. Proximate body composition is the analysis of water, fat, protein and ash contents of the fish (Love, 1980). Proximate composition is a good indicator of physiology which is needed for routine analysis of ...

  10. Proximate analysis of Lentinus squarrosulus (Mont.) Singer and ...

    African Journals Online (AJOL)

    Each of the mushroom species was separated into its stipe and pileus and used for proximate analysis. There was a highly significant difference (p<0.01) in the proximate composition of the two species. P. atroumbonata had significantly higher crude protein, crude fibre and moisture content than L. squarrosulus while the ...

  11. Proximity approach to problems in topology and analysis

    CERN Document Server

    Naimpally, Somashekhar

    2009-01-01

    Dieses Buch konzentriert das aktuelle Gesamtwissen zum Proximity-Konzept und stellt es dem Leser in gut strukturierter Form dar. Hauptaugenmerk liegt auf den vielfältigen Möglichkeiten, die sich aus dem Proximity-Konzept der räumlichen Nähe und seiner Verallgemeinerung im Nearness-Konzept ergeben.

  12. Systemic calciphylaxis presenting as a painful, proximal myopathy.

    OpenAIRE

    Edelstein, C. L.; Wickham, M. K.; Kirby, P. A.

    1992-01-01

    A renal transplant patient who presented with a painful, proximal myopathy due to systemic calciphylaxis is described. The myopathy preceded the characteristic skin and soft tissue necrosis. Systemic calciphylaxis should be considered in a dialysis or a renal transplant patient presenting with a painful proximal myopathy even in the absence of necrotic skin lesions.

  13. Genetics Home Reference: proximal 18q deletion syndrome

    Science.gov (United States)

    ... characteristic features. Most cases of proximal 18q deletion syndrome are the result of a new (de novo) deletion and are not inherited from a ... J, Fox PT, Stratton RF, Perry B, Hale DE. Recurrent interstitial deletions of proximal 18q: a new syndrome involving expressive speech delay. Am J Med Genet ...

  14. Proximal soil sensors and data fusion for precision agriculture

    NARCIS (Netherlands)

    Mahmood, H.S.

    2013-01-01

    different remote and proximal soil sensors are available today that can scan entire fields and give detailed information on various physical, chemical, mechanical and biological soil properties. The first objective of this thesis was to evaluate different proximal soil sensors available today and to

  15. Two Stages repair of proximal hypospadias: Review of 33 cases

    African Journals Online (AJOL)

    HussamHassan

    Background/Purpose: Proximal hypospadias with chordee is the most challenging variant of hypospadias to reconstruct. During the last 10 years, the approach to sever hypospadias has been controversial. Materials & Methods: During the period from June 2002 to December 2009, I performed 33 cases with proximal.

  16. Dutch population specific sex estimation formulae using the proximal femur.

    Science.gov (United States)

    Colman, K L; Janssen, M C L; Stull, K E; van Rijn, R R; Oostra, R J; de Boer, H H; van der Merwe, A E

    2018-05-01

    Sex estimation techniques are frequently applied in forensic anthropological analyses of unidentified human skeletal remains. While morphological sex estimation methods are able to endure population differences, the classification accuracy of metric sex estimation methods are population-specific. No metric sex estimation method currently exists for the Dutch population. The purpose of this study is to create Dutch population specific sex estimation formulae by means of osteometric analyses of the proximal femur. Since the Netherlands lacks a representative contemporary skeletal reference population, 2D plane reconstructions, derived from clinical computed tomography (CT) data, were used as an alternative source for a representative reference sample. The first part of this study assesses the intra- and inter-observer error, or reliability, of twelve measurements of the proximal femur. The technical error of measurement (TEM) and relative TEM (%TEM) were calculated using 26 dry adult femora. In addition, the agreement, or accuracy, between the dry bone and CT-based measurements was determined by percent agreement. Only reliable and accurate measurements were retained for the logistic regression sex estimation formulae; a training set (n=86) was used to create the models while an independent testing set (n=28) was used to validate the models. Due to high levels of multicollinearity, only single variable models were created. Cross-validated classification accuracies ranged from 86% to 92%. The high cross-validated classification accuracies indicate that the developed formulae can contribute to the biological profile and specifically in sex estimation of unidentified human skeletal remains in the Netherlands. Furthermore, the results indicate that clinical CT data can be a valuable alternative source of data when representative skeletal collections are unavailable. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Transillumination and HDR Imaging for Proximal Caries Detection.

    Science.gov (United States)

    Lederer, A; Kunzelmann, K H; Hickel, R; Litzenburger, F

    2018-02-01

    The purpose was to develop an in vitro model for the validation of near-infrared transillumination (NIRT) for proximal caries detection, to enhance NIRT with high-dynamic-range imaging (HDRI), and to compare both methods, using micro-computed tomography (µCT) as a reference standard. Both proximal surfaces of 53 healthy or decayed permanent human teeth were examined using the Diagnocam (DC) (KaVo) and NIRT with HDRI (NIRT-HDRI). NIRT was combined with HDRI to improve the diagnostic performance by reducing under- and overexposed image areas. For NIRT-HDRI, an exposure series was captured and merged into a single HDR image. A classification was applied according to lesion depth. All surfaces were assessed twice by 2 trained examiners, and additionally with µCT for validation. The Kappa statistic was used to calculate inter-rater reliability and agreement between DC and NIRT-HDRI. Inter-rater reliability (weighted Kappa, wκ) showed very good agreement for the DC (0.90) and NIRT-HDRI (0.96). The overall agreement (wκ) was almost perfect (0.85). In the individual categories (0 to 4), the agreement (simple Kappa) ranged from almost perfect (category 4) to moderate (1 and 2) to substantial (categories 0 and 3). Sensitivity and specificity of sound surfaces, enamel, and dentin caries ranged from 0.57 to 0.99 and were similar for both methods in the different categories. NIRT-HDRI had a higher sensitivity for sound surfaces and enamel caries, as well as a higher specificity for dentin caries. Regarding the obtained images, HDRI allowed for the detection of caries within a greater range of luminance levels, resulting in a more detailed visualization of structures without under- or overexposure. However, HDRI this did not improve the diagnostics significantly. Distinguishing between a processed demineralized enamel and dentin lesions appears to be a problem specific to NIRT and cannot be balanced using HDRI.

  18. [Self-expanding nitinol stents in proximal tracheal stenosis].

    Science.gov (United States)

    Hafner, B; Mann, W; Heussel, C P; Scherhag, A; Schlegel, J; Kauczor, H U

    2000-03-01

    The use of silicone- or metal stents in stenosis of the distal trachea and the bronchial system is a customary procedure [1-4], for example after tumor invasion or cicatricial stenosis after transplantation. In the proximal part of the trachea, on smaller, short and soft strictures we try to stabilise the trachea by the implantation of rings. Other methods are tracheal plasty or transverse tracheal resectomy [5-7]. In the case of longer or nearer subglottal stenoses the positioning of self-expanding nitinol stents has proven a simple, gentle and well-tolerated alternative procedure even in very serious disorders [1, 8, 9]. These stents can be placed in short narcosis under endoscopic control without great strain on the patient. We placed nitinol-stents in the proximal part of the trachea in eleven cases. In five cases dyspnoea caused by a tracheal collapse improved. In two further cases a tracheal stenosis with massive granulation tissue and cicatricial pull under an inlaid tracheal cannula was removed and the tracheostoma was closed. In four cases a solid, scarred and cartilaginous stenosis in the area of the cricoid and the upper tracheal rings was widened with laser and later on stented. Over an observation time of two years no complications showed safe one case in which a directly postoperative dislocation was repositioned quickly. The patients live without restrictions through the tracheal stenosis or a tracheostoma. In the best possible case epithelialization over the metal meshes develops so that a nearly normal mucus transportation is possible [1, 10-12].

  19. Proximity correction of high-dosed frame with PROXECCO

    Science.gov (United States)

    Eisenmann, Hans; Waas, Thomas; Hartmann, Hans

    1994-05-01

    Usefulness of electron beam lithography is strongly related to the efficiency and quality of methods used for proximity correction. This paper addresses the above issue by proposing an extension to the new proximity correction program PROXECCO. The combination of a framing step with PROXECCO produces a pattern with a very high edge accuracy and still allows usage of the fast correction procedure. Making a frame with a higher dose imitates a fine resolution correction where the coarse part is disregarded. So after handling the high resolution effect by means of framing, an additional coarse correction is still needed. Higher doses have a higher contribution to the proximity effect. This additional proximity effect is taken into account with the help of the multi-dose input of PROXECCO. The dose of the frame is variable, depending on the deposited energy coming from backscattering of the proximity. Simulation proves the very high edge accuracy of the applied method.

  20. Dynamic Assessment of EFL Learners' Listening Comprehension via Computerized Concept Mapping

    Science.gov (United States)

    Ebadi, Saman; Latif, Shokoufeh Vakili

    2015-01-01

    In Vygotsky's theory, learner's Zone of Proximal Development (ZPD) and autonomous performance could be further developed through social interaction with an expert. Computerized concept mapping enjoys the advantage of meeting learners' differences and therefore can be applied as a scaffold to support learning process.Taking a dynamic assessment…

  1. Interactive orbital proximity operations planning system

    Science.gov (United States)

    Grunwald, Arthur J.; Ellis, Stephen R.

    1990-01-01

    An interactive graphical planning system for on-site planning of proximity operations in the congested multispacecraft environment about the space station is presented. The system shows the astronaut a bird's eye perspective of the space station, the orbital plane, and the co-orbiting spacecraft. The system operates in two operational modes: (1) a viewpoint mode, in which the astronaut is able to move the viewpoint around in the orbital plane to range in on areas of interest; and (2) a trajectory design mode, in which the trajectory is planned. Trajectory design involves the composition of a set of waypoints which result in a fuel-optimal trajectory which satisfies all operational constraints, such as departure and arrival constraints, plume impingement constraints, and structural constraints. The main purpose of the system is to present the trajectory and the constraints in an easily interpretable graphical format. Through a graphical interactive process, the trajectory waypoints are edited until all operational constraints are satisfied. A series of experiments was conducted to evaluate the system. Eight airline pilots with no prior background in orbital mechanics participated in the experiments. Subject training included a stand-alone training session of about 6 hours duration, in which the subjects became familiar with orbital mechanics concepts and performed a series of exercises to familiarize themselves with the control and display features of the system. They then carried out a series of production runs in which 90 different trajectory design situations were randomly addressed. The purpose of these experiments was to investigate how the planning time, planning efforts, and fuel expenditures were affected by the planning difficulty. Some results of these experiments are presented.

  2. Selective proximal vagotomy with and without pyloroplasty

    International Nuclear Information System (INIS)

    Brodersen, E.

    1984-01-01

    It was the aim of the study described here to gain information relevant to the well-being of patients subjected to selective proximal vagotomy with or without pyroloplasty as soon as possible after surgery. For this purpose, particular care was taken to ascertain the frequency of recidivation and the post-operative occurrence of disturbances in the emptying of gastric contents. In 35 patients solely undergoing SPV and a further 12 individuals, where both SPV and pyroloplasty had been performed, gastric emptying was monitored using a gamma camera and computer system. All patients were given a standardised test meal consisting of 500 ml ready-made milk labeled with 2 mCi 99mTc-HSA. After the patients had been assigned to different study groups according to the gastric emptying rates established in the individual cases, it became evident that there was a correlation between gastric emptying time (T/2) and the occurrence of post-operative discomfort. In the majority of patients the gastric emptying rate was found to be increased as compared to individuals with a healthy stomach. Among a total of 8 patients showing delayed gastric emptying only one, who solely underwent SPV, reported post-operative discomfort. Markedly increased rates of gastric emptying (T/2 ≤ 5 min) were predominantly determined in patients subjected to SPV in conjunction with pyroloplasty. A dumping syndrome and diarrhea were diagnosed in every third patient. Clinical follow-up studies and questionnaires distributed among the study patients showed relapses to occur with a frequency of 6.7%, the recidivation of ulcera being confined to the group of patients merely undergoing SPV. (TRV) [de

  3. Proximally exposed A-bomb survivors. 2

    International Nuclear Information System (INIS)

    Kamada, Nanao

    1992-01-01

    Methods for observing chromosomes can be chronologically divided into the era of non-differential staining technique (1962-1975) and the era of differential staining method (since 1976). This paper reviews the literature of chromosomal aberrations in bone marrow cells found in the two eras. Findings during the era of 1962-1975 include the frequency of chromosomal aberrations in bone marrow cells, comparison of chromosomal aberrations in bone marrow cells and T lymphocytes, and annual variation of chromosomal aberrations. The frequency of chromosomal aberrations was high in proximally exposed A-bomb survivors (90.5% and 52.6% in A-bomb survivors exposed within 500 m and at 501-1,000 m, respectively); on the contrary, it was low in those exposed far from 1,000 m (6.2% or less). The frequency of chromosomal aberrations in bone marrow cells was lower than that in T lymphocytes (21.5% vs 27.1% in those exposed within 500 m and 14.1% vs 23% in those exposed at 501-1,000 m). Annual analysis for chromosomal aberrations has shown the somewhat dependence upon medullary hematopoiesis and virus infection. The advent of differential staining technique since 1976 has made it possible to clarify the type of chromosomal aberrations and site of breakage. Of 710 bone marrow cells taken from 13 A-bomb survivors exposed within 1,000 m, 121 cells (from 11 A-bomb survivors) exhibited chromosomal aberrations. In differential staining analysis, all 121 cells but one were found to be of stable type, such as translocation and inversion. Furthermore, the site of breakage was found to be non-randomly distributed. Analysis of chromosomal aberrations in bone marrow cells has advantages of reflecting dynamic condition of these cells and determining gradual progression into leukemia. (N.K.)

  4. Hypospadias and residential proximity to pesticide applications.

    Science.gov (United States)

    Carmichael, Suzan L; Yang, Wei; Roberts, Eric M; Kegley, Susan E; Wolff, Craig; Guo, Liang; Lammer, Edward J; English, Paul; Shaw, Gary M

    2013-11-01

    Experimental evidence suggests pesticides may be associated with hypospadias. Examine the association of hypospadias with residential proximity to commercial agricultural pesticide applications. The study population included male infants born from 1991 to 2004 to mothers residing in 8 California counties. Cases (n = 690) were ascertained by the California Birth Defects Monitoring Program; controls were selected randomly from the birth population (n = 2195). We determined early pregnancy exposure to pesticide applications within a 500-m radius of mother's residential address, using detailed data on applications and land use. Associations with exposures to physicochemical groups of pesticides and specific chemicals were assessed using logistic regression adjusted for maternal race or ethnicity and age and infant birth year. Forty-one percent of cases and controls were classified as exposed to 57 chemical groups and 292 chemicals. Despite >500 statistical comparisons, there were few elevated odds ratios with confidence intervals that excluded 1 for chemical groups or specific chemicals. Those that did were for monochlorophenoxy acid or ester herbicides; the insecticides aldicarb, dimethoate, phorate, and petroleum oils; and adjuvant polyoxyethylene sorbitol among all cases; 2,6-dinitroaniline herbicides, the herbicide oxyfluorfen, and the fungicide copper sulfate among mild cases; and chloroacetanilide herbicides, polyalkyloxy compounds used as adjuvants, the insecticides aldicarb and acephate, and the adjuvant nonyl-phenoxy-poly(ethylene oxy)ethanol among moderate and severe cases. Odds ratios ranged from 1.9 to 2.9. Most pesticides were not associated with elevated hypospadias risk. For the few that were associated, results should be interpreted with caution until replicated in other study populations.

  5. Effect of a feed/fast protocol on pH in the proximal equine stomach.

    Science.gov (United States)

    Husted, L; Sanchez, L C; Baptiste, K E; Olsen, S N

    2009-09-01

    Risk factors for the development of gastric squamous ulcers include various management procedures, such as intermittent feed deprivation that can occur during weight management regimens or stall and dry lot confinement. To investigate the effect of intermittent feed deprivation relative to continuous feed intake on proximal intragastric pH, specifically in the region of the squamous mucosa of the lesser curvature. In 6 horses, pH electrodes were placed just inside of the oesophageal sphincter in the stomach for each of two 72 h protocols (A and B) in a randomised, cross-over design. Protocol A consisted of 12 h fed, 12 h fasted, 24 h fed and 24 h fasted, in sequence. Protocol B consisted of 72 h fed. During the fed periods of each protocol, horses had ad libitum access to coastal Bermuda hay and were fed sweet feed (1 kg, b.i.d.). Horses had ad libitum access to water at all times. Proximal intragastric pH was significantly lower during protocol A, than during protocol B. However, hourly mean pH was significantly different only during the day and evening hours between protocols. During protocol B, mean proximal pH decreased significantly from 03.00 to 09.00 compared to 19.00 to 23.00 h. A moderate positive correlation of hay intake vs. proximal gastric pH could be established. Intermittent feed deprivation decreased proximal gastric pH in horses relative to those horses for which feed was not restricted. However, the effect was only significant when fasting occurred during the day and evening hours, as a nocturnal decrease in pH occurred simultaneously in the fed horses. Episodes of daytime feed deprivation should be avoided if possible, as proximal gastric acid exposure rapidly increases during such events.

  6. Treatment of Unstable Trochanteric Femur Fractures: Proximal Femur Nail Versus Proximal Femur Locking Compression Plate.

    Science.gov (United States)

    Singh, Ashutosh Kumar; Narsaria, Nidi; G R, Arun; Srivastava, Vivek

    Unstable trochanteric femur fractures are common fractures that are difficult to manage. We conducted a prospective study to compare functional outcomes and complications of 2 different implant designs, proximal femur nail (PFN) and proximal femur locking compression plate (PFLCP), used in internal fixation of unstable trochanteric femur fractures. On hospital admission, 48 patients with unstable trochanteric fractures were randomly assigned (using a sealed envelope method) to treatment with either PFN (24 patients) or PFLCP (24 patients). Perioperative data and complications were recorded. All cases were followed up for 2 years. The groups did not differ significantly (P > .05) in operative time, reduction quality, complications, hospital length of stay, union rate, or time to union. Compared with the PFLCP group, the PFN group had shorter incisions and less blood loss. Regarding functional outcomes, there was no significant difference in mean Harris Hip Score (P = .48) or Palmer and Parker mobility score (P = .58). Both PFN and PFLCP are effective in internal fixation of unstable trochanteric femur fractures.

  7. Dual pathology proximal median nerve compression of the forearm.

    LENUS (Irish Health Repository)

    Murphy, Siun M

    2013-12-01

    We report an unusual case of synchronous pathology in the forearm- the coexistence of a large lipoma of the median nerve together with an osteochondroma of the proximal ulna, giving rise to a dual proximal median nerve compression. Proximal median nerve compression neuropathies in the forearm are uncommon compared to the prevalence of distal compression neuropathies (eg Carpal Tunnel Syndrome). Both neural fibrolipomas (Refs. 1,2) and osteochondromas of the proximal ulna (Ref. 3) in isolation are rare but well documented. Unlike that of a distal compression, a proximal compression of the median nerve will often have a definite cause. Neural fibrolipoma, also called fibrolipomatous hamartoma are rare, slow-growing, benign tumours of peripheral nerves, most often occurring in the median nerve of younger patients. To our knowledge, this is the first report of such dual pathology in the same forearm, giving rise to a severe proximal compression of the median nerve. In this case, the nerve was being pushed anteriorly by the osteochondroma, and was being compressed from within by the intraneural lipoma. This unusual case highlights the advantage of preoperative imaging as part of the workup of proximal median nerve compression.

  8. Dual pathology proximal median nerve compression of the forearm.

    Science.gov (United States)

    Murphy, Siun M; Browne, Katherine; Tuite, David J; O'Shaughnessy, Michael

    2013-12-01

    We report an unusual case of synchronous pathology in the forearm- the coexistence of a large lipoma of the median nerve together with an osteochondroma of the proximal ulna, giving rise to a dual proximal median nerve compression. Proximal median nerve compression neuropathies in the forearm are uncommon compared to the prevalence of distal compression neuropathies (eg Carpal Tunnel Syndrome). Both neural fibrolipomas (Refs. 1,2) and osteochondromas of the proximal ulna (Ref. 3) in isolation are rare but well documented. Unlike that of a distal compression, a proximal compression of the median nerve will often have a definite cause. Neural fibrolipoma, also called fibrolipomatous hamartoma are rare, slow-growing, benign tumours of peripheral nerves, most often occurring in the median nerve of younger patients. To our knowledge, this is the first report of such dual pathology in the same forearm, giving rise to a severe proximal compression of the median nerve. In this case, the nerve was being pushed anteriorly by the osteochondroma, and was being compressed from within by the intraneural lipoma. This unusual case highlights the advantage of preoperative imaging as part of the workup of proximal median nerve compression. Copyright © 2013 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

  9. Digital contrast subtraction radiography for proximal caries diagnosis

    International Nuclear Information System (INIS)

    Kang, Byung Cheol; Yoon, Suk Ja

    2002-01-01

    To determine whether subtraction images utilizing contrast media can improve the diagnostic performance of proximal caries diagnosis compared to conventional periapical radiographic images. Thirty-six teeth with 57 proximal surfaces were radiographied using a size no.2 RVG-ui sensor (Trophy Radiology, Marne-la-Vallee, France). The teeth immersed in water-soluble contrast media and subtraction images were taken. Each tooth was then sectioned for histologic examination. The digital radiographic images and subtraction images were examined and interpreted by three dentists for proximal caries. The results of the proximal caries diagnosis were then verified with the results of the histologic examination. The proximal caries sensitivity using digital subtraction radiography was significantly higher than simply examining a single digital radiograph. The sensitivity of the proximal dentinal carious lesion when analyzed with the subtraction radiograph and the radiograph together was higher than with the subtraction radiograph or the radiograph alone. The use of subtraction radiography with contrast media may be useful for detecting proximal dentinal carious lesions.

  10. Effect of age on proximal esophageal response to swallowing

    Directory of Open Access Journals (Sweden)

    Roberto Oliveira Dantas

    2010-12-01

    Full Text Available CONTEXT: It has been demonstrated that the ageing process affects esophageal motility. OBJECTIVES: To evaluate the effect of the age on the proximal esophageal response to wet swallows. METHOD: We measured the proximal esophageal response to swallows of a 5 mL bolus of water in 69 healthy volunteers, 20 of them aged 18-30 years (group I, 27 aged 31-50 years (group II, and 22 aged 51-74 years (group III. We used the manometric method with continuous perfusion. The proximal esophageal contractions were recorded 5 cm from a pharyngeal recording site located 1 cm above the upper esophageal sphincter. The time between the onset of the pharyngeal and of the proximal esophageal recording (pharyngeal-esophageal time and the amplitude, duration and area under the curve of the proximal esophageal contraction were measured. RESULTS: The pharyngeal-esophageal time was shorter in group I subjects than in group II and III subjects (P<0.05. The duration of proximal esophageal contractions was longer in group I than in groups II and III (P<0.001. There was no differences between groups in the amplitude or area under the curve of contractions. There were no differences between groups II and III for any of the measurements. CONCLUSION: We conclude that the age may affects the response of the proximal esophagus to wet swallows.

  11. Giant proximity effect and critical opalescence in EuS

    Science.gov (United States)

    Charlton, Timothy; Ramos, Silvia; Quintanilla, Jorge; Suter, Andreas; Moodera, Jagadeesh

    2015-03-01

    The proximity effect is a type of wetting phenomenon where an ordered state, usually magnetism or superconductivity, ``leaks'' from one material into an adjacent one over some finite distance. For superconductors, the characteristic range is of the order of the coherence length, usually hundreds of nm. Nevertheless much longer, ``giant'' proximity effects have been observed in cuprate perovskite junctions. Such giant proximity effects can be understood by taking into account the divergence of the pairing susceptibility in the non-superconducting material when it is itself close to a superconducting instability: a superconducting version of critical opalescence. Since critical opalescence occurs in all second order phase transitions, giant proximity effects are expected to be general, therefor there must be a giant ferromagnetic proximity effect. Compared to its superconducting counterpart, the giant ferromagnetic proximity effect has the advantage that the order parameter (magnetization) can be observed directly. We have fabricated Co/EuS thin films and measured the magnetization profiles as a function of temperature using the complementary techniques of low energy muon relaxation and polarized neutron reflectivity. Details of the proximity effect near TCEuS will be presented.

  12. Assessing the Effect of Spatial Proximity on Urban Growth

    Directory of Open Access Journals (Sweden)

    Eduardo Gomes

    2018-04-01

    Full Text Available Land-Use/Cover Change (LUCC reacts to demographic pressures, economic trends, or improved transport networks. Urban growth with implications on LUCC patterns can be measured using a diversity of methods. Our study derives from Tobler’s first law of geography: ‘everything is related to everything else, but near things are more related than distant ones’. We identified and measured the influence of neighbouring distance on urban growth from the edge of existing urban areas. For that, we have developed a method, built using the NetLogo software tool, which we called Land-use chAnge and Neighbouring Distance (LAND. We selected Torres Vedras (Portugal to conduct our case study due to its increasing urban development in the past few years. The periods of analysis were 1995–2010, 1995–2007, and 2007–2010. The results have shown the influence and the effect of strong spatial correlation between the proximity of existing artificial surfaces and the emergence of new ones. The understanding of the patterns of urban growth is helpful to plan forward land developments. This method can be used to write guidelines for decision makers to monitor urban expansion and define spatial planning priorities.

  13. Reoperations following proximal interphalangeal joint nonconstrained arthroplasties.

    Science.gov (United States)

    Pritsch, Tamir; Rizzo, Marco

    2011-09-01

    To retrospectively analyze the reasons for reoperations following primary nonconstrained proximal interphalangeal (PIP) joint arthroplasty and review clinical outcomes in this group of patients with 1 or more reoperations. Between 2001 and 2009, 294 nonconstrained (203 pyrocarbon and 91 metal-plastic) PIP joint replacements were performed in our institution. A total of 76 fingers (59 patients) required reoperation (50 pyrocarbon and 26 metal-plastic). There were 40 women and 19 men with an average age of 51 years (range, 19-83 y). Primary diagnoses included osteoarthritis in 35, posttraumatic arthritis in 24, and inflammatory arthritis in 17 patients. There were 21 index, 27 middle, 18 ring, and 10 small fingers. The average number of reoperations per PIP joint was 1.6 (range, 1-4). A total of 45 joints had 1 reoperation, 19 had 2, 11 had 3, and 1 had 4. Extensor mechanism dysfunction was the most common reason for reoperation; it involved 51 of 76 fingers and was associated with Chamay or tendon-reflecting surgical approaches. Additional etiologies included component loosening in 17, collateral ligament failure in 10, and volar plate contracture in 8 cases. Inflammatory arthritis was associated with collateral ligament failure. Six fingers were eventually amputated, 9 had PIP joint arthrodeses, and 2 had resection arthroplasties. The arthrodesis and amputation rates correlated with the increased number of reoperations per finger. Clinically, most patients had no or mild pain at the most recent follow-up, and the PIP joint range-of-motion was not significantly different from preoperative values. Pain levels improved with longer follow-up. Reoperations following primary nonconstrained PIP joint arthroplasties are common. Extensor mechanism dysfunction was the most common reason for reoperation. The average reoperation rate was 1.6, and arthrodesis and amputation are associated with an increasing number of operations. Overall clinical outcomes demonstrated no

  14. Proximal caries detection: Sirona Sidexis versus Kodak Ektaspeed Plus.

    Science.gov (United States)

    Khan, Emad A; Tyndall, Donald A; Ludlow, John B; Caplan, Daniel

    2005-01-01

    This study compared the accuracy of intraoral film and a charge-coupled device (CCD) receptor for proximal caries detection. Four observers evaluated images of the proximal surfaces of 40 extracted posterior teeth. The presence or absence of caries was scored using a five-point confidence scale. The actual status of each surface was determined from ground section histology. Responses were evaluated by means of receiver operating characteristic (ROC) analysis. Areas under ROC curves (Az) were assessed through a paired t-test. The performance of the CCD-based intraoral sensor was not different statistically from Ektaspeed Plus film in detecting proximal caries.

  15. [Avulsion of the Proximal Hamstring Insertion. Case Reports].

    Science.gov (United States)

    Mizera, R; Harcuba, R; Kratochvíl, J

    2016-01-01

    Proximal hamstring avulsion is an uncommon muscle injury with a lack of consensus on indications and the timing and technique of surgery. Poor clinical symptoms and difficulties in the diagnostic process can lead to a false diagnosis. The authors present three cases of proximal hamstring avulsion, two complete and one partial ruptures of the biceps femoris muscle. MRI and ultrasound scans were used for optimal treatment alignment. Acute surgery reconstruction (hamstring strength. Two interesting systematic reviews published on the treatment of proximal hamstring avulsion are discussed in the final part of the paper. Key words: hamstring, rupture, avulsion.

  16. Influence of population size, density, and proximity to talent clubs on the likelihood of becoming elite youth athlete.

    Science.gov (United States)

    Rossing, N N; Stentoft, D; Flattum, A; Côté, J; Karbing, D S

    2018-03-01

    Previous studies have found significant differences in the likelihood of becoming an elite athlete depending on community population sizes and densities, an effect known as the place of early development, or birthplace effect. However, the results have not been consistent between sports or European countries. As both professional and voluntary clubs are vital to the talent development systems in Europe, the proximity of an athlete's place of early development to the location of talent clubs may be an important predictor of the likelihood of becoming an elite athlete. Therefore, the primary purpose of this study was to investigate the place of early development effect and the effect of proximity to talent clubs. The samples included elite youth league athletes (579 football and 311 handball) and national youth athletes (85 football and 80 handball) and a comparison group of 147 221 football and 26 290 handball youth athletes. Odds ratios showed variations in the optimal community size and density across sports. Geospatial analyses of proximity to talent clubs highlighted a trend indicating that most national and elite youth league athletes in both sports had their place of early development in their sport near a talent club. The results suggest that proximity is an important predictor in the development of expertise across sports, but future studies need to clarify if proximity is important in other countries and sports. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  17. Using Picture Books as Paired Texts to Teach Educational Theories

    Science.gov (United States)

    Gao, Yang; Bintz, William P.

    2015-01-01

    Picture books, when used thoughtfully and artfully, can teach theories to graduate students in literacy and foreign language education. In this article, the authors described how a pair of picture books is used to teach Vygotsky's "Zone of Proximal Development" and Krashen's "Input Hypothesis" in the fields of literacy…

  18. Model of Models: Preservice Teachers in a Vygotskian Scaffold

    Science.gov (United States)

    De Leon, Leticia

    2012-01-01

    Lev Vygotsky's revolutionary ideas have extended knowledge on the process of education--in particular, on mediating learning through language--for over 40 years. The zone of proximal development strengthened a new paradigm for learning and instruction, one which others, such as Bruner, formulated into the concept of scaffolding. Action research…

  19. Peer Scaffolding Behaviors Emerging in Revising a Written Task: A Microgenetic Analysis

    Science.gov (United States)

    Ranjbar, Naser; Ghonsooly, Behzad

    2017-01-01

    Vygotsky's writings on Sociocultural Theory (SCT) of mind, his concept of Zone of Proximal Development (ZPD) and its related metaphor, scaffolding, serve as the theoretical basis for the study of peer collaboration. This paper aimed at examining the effects of peer-scaffolding on EFL writing ability and finding out how revising techniques are…

  20. Influence of muscle groups' activation on proximal femoral growth tendency.

    Science.gov (United States)

    Yadav, Priti; Shefelbine, Sandra J; Pontén, Eva; Gutierrez-Farewik, Elena M

    2017-12-01

    Muscle and joint contact force influence stresses at the proximal growth plate of the femur and thus bone growth, affecting the neck shaft angle (NSA) and femoral anteversion (FA). This study aims to illustrate how different muscle groups' activation during gait affects NSA and FA development in able-bodied children. Subject-specific femur models were developed for three able-bodied children (ages 6, 7, and 11 years) using magnetic resonance images. Contributions of different muscle groups-hip flexors, hip extensors, hip adductors, hip abductors, and knee extensors-to overall hip contact force were computed. Specific growth rate for the growth plate was computed, and the growth was simulated in the principal stress direction at each element in the growth front. The predicted growth indicated decreased NSA and FA (of about [Formula: see text] over a four-month period) for able-bodied children. Hip abductors contributed the most, and hip adductors, the least, to growth rate. All muscles groups contributed to a decrease in predicted NSA ([Formula: see text]0.01[Formula: see text]-0.04[Formula: see text] and FA ([Formula: see text]0.004[Formula: see text]-[Formula: see text]), except hip extensors and hip adductors, which showed a tendency to increase the FA ([Formula: see text]0.004[Formula: see text]-[Formula: see text]). Understanding influences of different muscle groups on long bone growth tendency can help in treatment planning for growing children with affected gait.

  1. Proximity effects of high voltage electric power transmission lines on ...

    African Journals Online (AJOL)

    Yomi

    2010-08-18

    Aug 18, 2010 ... transmission lines on ornamental plant growth. Zeki Demir ... The effects of proximity to power-line on specific leaf area and seedling dbh were tested .... during vegetation season is about 72% and common wind blow.

  2. Nutritive Value Assessment of Four Crop Residues by Proximate ...

    African Journals Online (AJOL)

    Dr Grace Tona

    Ladoke Akintola University of Technology, P.M.B. 4000, Ogbomoso, Nigeria ... Abstract. This study estimated the proximate composition and in vitro gas production parameters of rice husk, bean ... farms and industries generate large quantities.

  3. Computational proximity excursions in the topology of digital images

    CERN Document Server

    Peters, James F

    2016-01-01

    This book introduces computational proximity (CP) as an algorithmic approach to finding nonempty sets of points that are either close to each other or far apart. Typically in computational proximity, the book starts with some form of proximity space (topological space equipped with a proximity relation) that has an inherent geometry. In CP, two types of near sets are considered, namely, spatially near sets and descriptivelynear sets. It is shown that connectedness, boundedness, mesh nerves, convexity, shapes and shape theory are principal topics in the study of nearness and separation of physical aswell as abstract sets. CP has a hefty visual content. Applications of CP in computer vision, multimedia, brain activity, biology, social networks, and cosmology are included. The book has been derived from the lectures of the author in a graduate course on the topology of digital images taught over the past several years. Many of the students have provided important insights and valuable suggestions. The topics in ...

  4. Proximate composition and nutrient content of some wild and ...

    African Journals Online (AJOL)

    Proximate composition and nutrient content of some wild and cultivated ... Ca, P, K), one minor mineral (Fe) constituent and vitamin C content were determined. ... Mineral content (P and K) in the mushroom sporophores were found to be ...

  5. Effects of Fermentation and Extrusion on the Proximate Composition ...

    African Journals Online (AJOL)

    Prof. Ogunji

    protein malnutrition persists as a principal health problem among children .... Proximate analysis: Moisture content ... nitrogen by a factor of 6.25. Crude fat ... Statistical analysis: The data were ..... interaction of amino acid in maillard reactions.

  6. Proximate composition and mineral contents of Pebbly fish, Alestes ...

    African Journals Online (AJOL)

    ACSS

    /100 g) were significantly .... Proximate analysis of A. baremoze fillets according to sample sizes in a study in. Uganda .... present in the fish tissues in trace amounts. ... The zinc contents in fish samples of ..... (mercury, cadmium, lead, tin and.

  7. Effects of Planting Locations on the Proximate Compositions of ...

    African Journals Online (AJOL)

    ADOWIE PERE

    Ash, moisture, crude fat, crude fibre, carbohydrate and protein contents were determined according ... All fruits, vegetables, legumes (beans and peas), and the grains we eat ... isolate and quantify each proximate present in the plant material.

  8. Proximity Effect between Two Superconductors Spatially Resolved by Scanning Tunneling Spectroscopy

    Directory of Open Access Journals (Sweden)

    V. Cherkez

    2014-03-01

    Full Text Available We present a combined experimental and theoretical study of the proximity effect in an atomic-scale controlled junction between two different superconductors. Elaborated on a Si(111 surface, the junction comprises a Pb nanocrystal with an energy gap Δ_{1}=1.2  meV, connected to a crystalline atomic monolayer of lead with Δ_{2}=0.23  meV. Using in situ scanning tunneling spectroscopy, we probe the local density of states of this hybrid system both in space and in energy, at temperatures below and above the critical temperature of the superconducting monolayer. Direct and inverse proximity effects are revealed with high resolution. Our observations are precisely explained with the help of a self-consistent solution of the Usadel equations. In particular, our results demonstrate that in the vicinity of the Pb islands, the Pb monolayer locally develops a finite proximity-induced superconducting order parameter, well above its own bulk critical temperature. This leads to a giant proximity effect where the superconducting correlations penetrate inside the monolayer a distance much larger than in a nonsuperconducting metal.

  9. Are there radiologically identifiable prodromal changes in Thoroughbred racehorses with parasagittal fractures of the proximal phalanx?

    Science.gov (United States)

    Smith, M R W; Wright, I M

    2014-01-01

    Fractures of the proximal phalanx are generally considered to result from monotonic supraphysiological loads, but radiological observations from clinical cases suggest there may be a stress-related aetiology. To determine whether there are radiologically identifiable prodromal changes in Thoroughbred racehorses with confirmed parasagittal fractures of the proximal phalanx. Retrospective cross-sectional study. Case records and radiographs of Thoroughbred racehorses with parasagittal fractures of the proximal phalanx were analysed. Thickness of the subchondral bone plate was measured in fractured and contralateral limbs, and additional radiological features consistent with prodromal fracture pathology documented. The subchondral bone plate was significantly thicker in affected than in contralateral limbs. Evidence of additional prodromal fracture pathology was observed in 15/110 (14%) limbs with parasagittal fractures, and in 4% of contralateral limbs. The results of this study are not consistent with monotonic loading as a cause of fracture in at least a proportion of cases, but suggest a stress-related aetiology. Increased thickness of the subchondral bone plate may reflect (failed) adaptive changes that precede fracture. Better understanding of the aetiology of fractures of the proximal phalanx may help develop strategies to reduce the risk of fracture. © 2013 EVJ Ltd.

  10. Inexact proximal Newton methods for self-concordant functions

    DEFF Research Database (Denmark)

    Li, Jinchao; Andersen, Martin Skovgaard; Vandenberghe, Lieven

    2016-01-01

    with an application to L1-regularized covariance selection, in which prior constraints on the sparsity pattern of the inverse covariance matrix are imposed. In the numerical experiments the proximal Newton steps are computed by an accelerated proximal gradient method, and multifrontal algorithms for positive definite...... matrices with chordal sparsity patterns are used to evaluate gradients and matrix-vector products with the Hessian of the smooth component of the objective....

  11. Hemiarthroplasty for proximal humeral fracture: restoration of the Gothic arch.

    Science.gov (United States)

    Krishnan, Sumant G; Bennion, Phillip W; Reineck, John R; Burkhead, Wayne Z

    2008-10-01

    Proximal humerus fractures are the most common fractures of the shoulder girdle, and initial management of these injuries often determines final outcome. When arthroplasty is used to manage proximal humeral fractures, surgery remains technically demanding, and outcomes have been unpredictable. Recent advances in both technique and prosthetic implants have led to more successful and reproducible results. Key technical points include restoration of the Gothic arch, anatomic tuberosity reconstruction, and minimal soft tissue dissection.

  12. The sooner, the better: exercise outcome proximity and intrinsic motivation.

    Science.gov (United States)

    Evans, M Blair; Cooke, Lisa M; Murray, Robyn A; Wilson, Anne E

    2014-11-01

    Despite evidence that outcomes are highly valued when they are expected sooner rather than further into the future (Ainslie, 1975), limited research effort has been devoted to understanding the role of exercise outcome proximity. The purpose of this study was to examine how temporal proximity to positive outcomes influences exercisers' intrinsic motivation. We expected that focusing people on temporally proximal exercise outcomes would increase intrinsic motivation, especially among low-frequency exercisers. This online experimental study was completed by 135 community exercisers (Mage  = 31.11, SD = 10.29; 62% female) who reported an average of 4.86 exercise bouts per week (SD = 2.12). Participants were randomly assigned to a condition that primed temporally proximal positive exercise outcomes (i.e. experienced during or directly following an exercise bout) or temporally distal outcomes (i.e. experienced after days, months, or years of regular exercise). Participants then reported perceptions of behavioral regulation in exercise. As expected, the proximal exercise outcome condition elicited increased intrinsic regulation among those participants who exercised less frequently (i.e. 1 SD below the mean). This study reveals the importance of considering proximity as an important dimension of exercise outcomes-particularly when promoting intrinsic motivation among relatively infrequent exercisers. © 2014 The International Association of Applied Psychology.

  13. Psychological responses to the proximity of climate change

    Science.gov (United States)

    Brügger, Adrian; Dessai, Suraje; Devine-Wright, Patrick; Morton, Thomas A.; Pidgeon, Nicholas F.

    2015-12-01

    A frequent suggestion to increase individuals' willingness to take action on climate change and to support relevant policies is to highlight its proximal consequences, that is, those that are close in space and time. But previous studies that have tested this proximizing approach have not revealed the expected positive effects on individual action and support for addressing climate change. We present three lines of psychological reasoning that provide compelling arguments as to why highlighting proximal impacts of climate change might not be as effective a way to increase individual mitigation and adaptation efforts as is often assumed. Our contextualization of the proximizing approach within established psychological research suggests that, depending on the particular theoretical perspective one takes on this issue, and on specific individual characteristics suggested by these perspectives, proximizing can bring about the intended positive effects, can have no (visible) effect or can even backfire. Thus, the effects of proximizing are much more complex than is commonly assumed. Revealing this complexity contributes to a refined theoretical understanding of the role that psychological distance plays in the context of climate change and opens up further avenues for future research and for interventions.

  14. HEMATOMA OF THE PROXIMAL NAIL FOLD. REPORT OF 41 CASES

    Directory of Open Access Journals (Sweden)

    Chang Patricia

    2011-04-01

    Full Text Available Background: The proximal fold is an important part of the nail apparatus it contributes to the formation of the nail plate and through the cuticle acts as an impermeable barrier protecting it from any cause.Objective: To know the proximal nail fold hematoma caused by the use of pulse oximeter.Material and Methods: A descriptive study was conducted in 41 patients with proximal nail hematoma secondary to the use of oximetry in patients hospitalized in the Intermediate and Intensive Care Unit at the Hospital General de Enfermedades from December 1, 2007 to December 31, 2010.Results: We studied 41 patients with proximal nail fold hematoma secondary to the use of oximeter, 30 (73.1% were males and 11 (26.8% females. The numbers of fingers affected by pulse oximeter were in one digit. 30 (73.1% cases, in two digits 6 (14.6%, in three digits 3 (7.3%, in 4 digits 1 (2.4% and in 5 digits 1 (2.4% case. The most affected proximal nail fold was right index: 24 (58.5%, right middle 11 (26.8%, right ring 6 (14.6%, left index 12 (29.2%, and left middle 6 (14.6% cases.Conclusions: Hematomas of the proximal nail fold may be caused by different traumatisms. The use of pulse oximeter is one of them.

  15. The development of individual purposes: Creating actuality through novelty

    DEFF Research Database (Denmark)

    Valsiner, Jaan

    2011-01-01

    This chapter proposes a theoretical model to make sense of how any human being can face future challenges at the present through cultural signs: which particular forms the sign-construction takes, how deep (or shallow) the hierarchical structure of semiotic mediation is, and how temporary or quasi......-permanent it might be. The model is rooted in Vygotsky's focus on the dialectical nature of human development, and elaborated in life-course psychology by TEM (Trajectory Equifinality Model of Tatsuya Sato). The making of individual purposes is a process of anticipating the future relations with the changing context...

  16. Proximal tubular dysfunction as an indicator of chronic graft dysfunction

    Directory of Open Access Journals (Sweden)

    N.O.S. Câmara

    2009-03-01

    Full Text Available New strategies are being devised to limit the impact of renal sclerosis on graft function. Individualization of immunosuppression, specifically the interruption of calcineurin-inhibitors has been tried in order to promote better graft survival once chronic graft dysfunction has been established. However, the long-term impact of these approaches is still not totally clear. Nevertheless, patients at higher risk for tubular atrophy and interstitial fibrosis (TA/IF development should be carefully monitored for tubular function as well as glomerular performance. Since tubular-interstitial impairment is an early event in TA/IF pathogenesis and associated with graft function, it seems reasonable that strategies directed at assessing tubular structural integrity and function would yield important functional and prognostic data. The measurement of small proteins in urine such as α-1-microglobulin, N-acetyl-beta-D-glucosaminidase, alpha/pi S-glutathione transferases, β-2 microglobulin, and retinol binding protein is associated with proximal tubular cell dysfunction. Therefore, its straightforward assessment could provide a powerful tool in patient monitoring and ongoing clinical assessment of graft function, ultimately helping to facilitate longer patient and graft survival associated with good graft function.

  17. Event-triggered Decision Propagation in Proximity Networks

    Directory of Open Access Journals (Sweden)

    Soumik eSarkar

    2014-12-01

    Full Text Available This paper proposes a novel event-triggered formulation as an extension of the recently develo-ped generalized gossip algorithm for decision/awareness propagation in mobile sensor networksmodeled as proximity networks. The key idea is to expend energy for communication (messagetransmission and reception only when there is any event of interest in the region of surveillance.The idea is implemented by using an agent’s belief about presence of a hotspot as feedback tochange its probability of (communication activity. In the original formulation, the evolution ofnetwork topology and the dynamics of decision propagation were completely decoupled whichis no longer the case as a consequence of this feedback policy. Analytical results and numeri-cal experiments are presented to show a significant gain in energy savings with no change inthe first moment characteristics of decision propagation. However, numerical experiments showthat the second moment characteristics may change and theoretical results are provided forupper and lower bounds for second moment characteristics. Effects of false alarms on networkformation and communication activity are also investigated.

  18. PHOTOJOURNALISM AND PROXIMITY IMAGES: two points of view, two professions?

    Directory of Open Access Journals (Sweden)

    Daniel Thierry

    2011-06-01

    Full Text Available For many decades, classic photojournalistic practice, firmly anchored in a creed established since Lewis Hine (1874-1940, has developed a praxis and a doxa that have barely been affected by the transformations in the various types of journalism. From the search for the “right image” which would be totally transparent by striving to refute its enunciative features from a perspective of maximumobjectivity, to the most seductive photography at supermarkets by photo agencies, the range of images seems to be decidedly framed. However, far from constituting high-powered reportingor excellent photography that is rewarded with numerous international prizes and invitations to the media-artistic world, local press photography remains in the shadows. How does oneoffer a representation of one’s self that can be shared in the local sphere? That is the first question which editors of the local daily and weekly press must grapple with. Using illustrations of the practices, this article proposes an examination of the origins ofthese practices and an analysis grounded on the originality of theauthors of these proximity photographs.

  19. Ipsilateral proximal femur and shaft fractures treated with hip screws and a reamed retrograde intramedullary nail.

    Science.gov (United States)

    Ostrum, Robert F; Tornetta, Paul; Watson, J Tracy; Christiano, Anthony; Vafek, Emily

    2014-09-01

    Although not common, proximal femoral fractures associated with ipsilateral shaft fractures present a difficult management problem. A variety of surgical options have been employed with varying results. We investigated the use of hip screws and a reamed retrograde intramedullary (IM) nail for the treatment of this combined fracture pattern in terms of postoperative alignment (malunion), nonunion, and complications. Between May 2002 and October 2011, a total of 95 proximal femoral fractures with associated shaft fractures were treated at three participating Level 1 trauma centers; all were treated with hip screw fixation (cannulated screws or sliding hip screws) and retrograde reamed IM nails. The medical records of these patients were reviewed retrospectively for alignment, malunion, nonunion, and complications. Followup was available on 92 of 95 (97%) of the patients treated with hip screws and a retrograde nail. Forty were treated with a sliding hip screw, and 52 were treated with cannulated screws. There were five proximal malunions in this series (5%). The union rate was 98% (90 of 92) for the femoral neck fractures and 91.3% (84 of 92) for the femoral shaft fractures after the initial surgery. There were two nonunions of comminuted femoral neck fractures after cannulated screw fixation. There was no difference in femoral neck union or alignment when comparing cannulated screws to a sliding hip screw. Four open comminuted femoral shaft fractures went on to nonunion and required secondary surgery to obtain union, and one patient developed symptomatic avascular necrosis. The treatment of ipsilateral proximal femoral neck and shaft fractures with hip screw fixation and a reamed retrograde nail demonstrated a high likelihood of union for the femoral neck fractures and a low risk of malunion. Comminution and initial displacement of the proximal femoral fracture may still lead to a small incidence of malunion or nonunion, and open comminuted femoral shaft fractures

  20. Preputial reconstruction and tubularized incised plate urethroplasty in proximal hypospadias with ventral penile curvature.

    Science.gov (United States)

    Bhat, Amilal; Gandhi, Ajay; Saxena, Gajendra; Choudhary, Gautam Ram

    2010-10-01

    Objective of this study was to assess the feasibility and results of preputial reconstruction and tubularized incised plate urethroplasty (TIP) in patients of proximal hypospadias with ventral penile curvature. Twenty-seven patients of proximal hypospadias who underwent preputioplasty with TIP were evaluated retrospectively. Ventral curvature was corrected by mobilization of the urethral plate with the corpus spongiosum and the proximal urethra; dorsal plication was added according to the severity of curvature. Feasibility of preputial reconstruction was assessed by applying 3 stay sutures-the first to fix the skin at the corona, the second at the junction of the inner and outer preputial skin for pulling up the skin over the glans, and the third stay on penile skin at the level of the corona for retracting the skin. Preputial reconstruction consisted of a standard 3 layered re-approximation of the margins of the dorsal hood. Age of the patients varied from 10 months to 21 years with an average of 6 years and 4 months. Ventral curvature (mild 10, moderate 13, and severe 4 cases) was corrected by the mobilization of the urethral plate and spongiosum in 14 patients, 11 cases had mobilization of the proximal urethra in addition and 2 patients required single stitch dorsal plication with the above-mentioned steps. Two patients developed urethral fistula and 1 had preputial dehiscence. Preputioplasty with TIP is feasible in proximal hypospadias with curvature without increasing the complication rate. Postoperative phimosis can be prevented by on-table testing of the adequacy of preputial skin by 3 stay sutures.

  1. The Hounsfield value for cortical bone geometry in the proximal humerus - an in vitro study

    International Nuclear Information System (INIS)

    Lim Fat, Daren; Kennedy, Jim; Galvin, Rose; O'Brien, Fergal; Mc Grath, Frank; Mullett, Hannan

    2012-01-01

    Fractures of the proximal humerus represent a major osteoporotic burden. Recent developments in CT imaging have emphasized the importance of cortical bone thickness distribution in the prevention and management of fragility fractures. We aimed to experimentally define the CT density of cortical bone in the proximal humerus for building cortical geometry maps. With ethical approval, we used ten fresh-frozen human proximal humeri. These were stripped of all soft tissue and high-resolution CT images were then taken. The humeral heads were then subsequently resected to allow access to the metaphyseal area. Using curettes, cancellous bone was removed down to hard cortical bone. Another set of CT images of the reamed specimen was then taken. Using CT imaging software and a CAD interface, we then compared cortical contours at different CT density thresholds to the reference inner cortical contour of our reamed specimens. Working with 3D model representations of these cortical maps, we were able to accurately make distance comparison analyses based on different CT thresholds. We could compute a single closest value at 700 HU. No difference was found in the HU-based contours generated along the 500-900 HU pixels (p = 1.000). The contours were significantly different from those generated at 300, 400, 1,000, and 1,100 HU. A Hounsfield range of 500-900 HU can accurately depict cortical bone geometry in the proximal humerus. Thresholding outside this range leads to statistically significant inaccuracies. Our results concur with a similar range reported in the literature for the proximal femur. Knowledge of regional variations in cortical bone thickness has direct implications for basic science studies on osteoporosis and its treatment, but is also important for the orthopedic surgeon since our decision for treatment options is often guided by local bone quality. (orig.)

  2. PROXIMAL: a method for Prediction of Xenobiotic Metabolism.

    Science.gov (United States)

    Yousofshahi, Mona; Manteiga, Sara; Wu, Charmian; Lee, Kyongbum; Hassoun, Soha

    2015-12-22

    Contamination of the environment with bioactive chemicals has emerged as a potential public health risk. These substances that may cause distress or disease in humans can be found in air, water and food supplies. An open question is whether these chemicals transform into potentially more active or toxic derivatives via xenobiotic metabolizing enzymes expressed in the body. We present a new prediction tool, which we call PROXIMAL (Prediction of Xenobiotic Metabolism) for identifying possible transformation products of xenobiotic chemicals in the liver. Using reaction data from DrugBank and KEGG, PROXIMAL builds look-up tables that catalog the sites and types of structural modifications performed by Phase I and Phase II enzymes. Given a compound of interest, PROXIMAL searches for substructures that match the sites cataloged in the look-up tables, applies the corresponding modifications to generate a panel of possible transformation products, and ranks the products based on the activity and abundance of the enzymes involved. PROXIMAL generates transformations that are specific for the chemical of interest by analyzing the chemical's substructures. We evaluate the accuracy of PROXIMAL's predictions through case studies on two environmental chemicals with suspected endocrine disrupting activity, bisphenol A (BPA) and 4-chlorobiphenyl (PCB3). Comparisons with published reports confirm 5 out of 7 and 17 out of 26 of the predicted derivatives for BPA and PCB3, respectively. We also compare biotransformation predictions generated by PROXIMAL with those generated by METEOR and Metaprint2D-react, two other prediction tools. PROXIMAL can predict transformations of chemicals that contain substructures recognizable by human liver enzymes. It also has the ability to rank the predicted metabolites based on the activity and abundance of enzymes involved in xenobiotic transformation.

  3. A proximity algorithm accelerated by Gauss-Seidel iterations for L1/TV denoising models

    Science.gov (United States)

    Li, Qia; Micchelli, Charles A.; Shen, Lixin; Xu, Yuesheng

    2012-09-01

    Our goal in this paper is to improve the computational performance of the proximity algorithms for the L1/TV denoising model. This leads us to a new characterization of all solutions to the L1/TV model via fixed-point equations expressed in terms of the proximity operators. Based upon this observation we develop an algorithm for solving the model and establish its convergence. Furthermore, we demonstrate that the proposed algorithm can be accelerated through the use of the componentwise Gauss-Seidel iteration so that the CPU time consumed is significantly reduced. Numerical experiments using the proposed algorithm for impulsive noise removal are included, with a comparison to three recently developed algorithms. The numerical results show that while the proposed algorithm enjoys a high quality of the restored images, as the other three known algorithms do, it performs significantly better in terms of computational efficiency measured in the CPU time consumed.

  4. A proximity algorithm accelerated by Gauss–Seidel iterations for L1/TV denoising models

    International Nuclear Information System (INIS)

    Li, Qia; Shen, Lixin; Xu, Yuesheng; Micchelli, Charles A

    2012-01-01

    Our goal in this paper is to improve the computational performance of the proximity algorithms for the L1/TV denoising model. This leads us to a new characterization of all solutions to the L1/TV model via fixed-point equations expressed in terms of the proximity operators. Based upon this observation we develop an algorithm for solving the model and establish its convergence. Furthermore, we demonstrate that the proposed algorithm can be accelerated through the use of the componentwise Gauss–Seidel iteration so that the CPU time consumed is significantly reduced. Numerical experiments using the proposed algorithm for impulsive noise removal are included, with a comparison to three recently developed algorithms. The numerical results show that while the proposed algorithm enjoys a high quality of the restored images, as the other three known algorithms do, it performs significantly better in terms of computational efficiency measured in the CPU time consumed. (paper)

  5. Calculus Rules for V-Proximal Subdifferentials in Smooth Banach Spaces

    Directory of Open Access Journals (Sweden)

    Messaoud Bounkhel

    2016-01-01

    Full Text Available In 2010, Bounkhel et al. introduced new proximal concepts (analytic proximal subdifferential, geometric proximal subdifferential, and proximal normal cone in reflexive smooth Banach spaces. They proved, in p-uniformly convex and q-uniformly smooth Banach spaces, the density theorem for the new concepts of proximal subdifferential and various important properties for both proximal subdifferential concepts and the proximal normal cone concept. In this paper, we establish calculus rules (fuzzy sum rule and chain rule for both proximal subdifferentials and we prove the Bishop-Phelps theorem for the proximal normal cone. The limiting concept for both proximal subdifferentials and for the proximal normal cone is defined and studied. We prove that both limiting constructions coincide with the Mordukhovich constructions under some assumptions on the space. Applications to nonconvex minimisation problems and nonconvex variational inequalities are established.

  6. MR imaging of proximal femur: age-related changes

    International Nuclear Information System (INIS)

    Kim, Ju Heon; Jeon, Woo Jin; Sohn, Cheol Ho; Park, Mi Ok; Lee, Seong Mun; Joo, Yang Gu; Suh, Soo Jhi; Pyun, Young Sik

    1995-01-01

    The purpose of this study is to illustrate MR patterns of signal intensity of proximal femur in normal subjects according to the age distribution. T1-weighted MR images of the proximal femur in 125 subjects, aged 13 days to 25 years, were retrospectively analyzed. Age distribution was classified to 4 groups; below 4 months, 5 months to 4 years, 5 years to 14 years, and 15 years to 25 years. By the age of 4 months, the non-ossified femoral epiphysis was seen as intermediate-signal-intensity cartilage. At 5 months-4 years, the ossified femoral capital epiphysis was seen within intermediate-signal-intensity cartilage and appeared as decreased or increased signal-intensity red or yellow marrow surrounded by a rim of low-signal-intensity cortical bone. At 5-14 years, the ossified femoral capital and greater trochanteric epiphysis were seen within the intermediate-signal-intensity cartilage and appeared as decreased or increased signal-intensity red or yellow marrow. At 15-25 years, the proximal metaphyseal marrow showed increased signal intensity. Four patterns of the metaphyseal marrow were recognized by Ricci et al. The frequency of pattern 1 a progressively decreased with age. Pattern 2 and 3 were visible in the 15-25 years age group. An understanding of the spectrum of normal age-related change of the proximal femoral cartilage and marrow patterns serves as the foundation for interpretation of proximal femur pathologies

  7. Topology of digital images visual pattern discovery in proximity spaces

    CERN Document Server

    Peters, James F

    2014-01-01

    This book carries forward recent work on visual patterns and structures in digital images and introduces a near set-based a topology of digital images. Visual patterns arise naturally in digital images viewed as sets of non-abstract points endowed with some form of proximity (nearness) relation. Proximity relations make it possible to construct uniform topolo- gies on the sets of points that constitute a digital image. In keeping with an interest in gaining an understanding of digital images themselves as a rich source of patterns, this book introduces the basics of digital images from a computer vision perspective. In parallel with a computer vision perspective on digital images, this book also introduces the basics of prox- imity spaces. Not only the traditional view of spatial proximity relations but also the more recent descriptive proximity relations are considered. The beauty of the descriptive proximity approach is that it is possible to discover visual set patterns among sets that are non-overlapping ...

  8. Biomechanical evaluation of straight antegrade nailing in proximal humeral fractures: the rationale of the "proximal anchoring point".

    Science.gov (United States)

    Euler, Simon A; Petri, Maximilian; Venderley, Melanie B; Dornan, Grant J; Schmoelz, Werner; Turnbull, Travis Lee; Plecko, Michael; Kralinger, Franz S; Millett, Peter J

    2017-09-01

    Varus failure is one of the most common failure modes following surgical treatment of proximal humeral fractures. Straight antegrade nails (SAN) theoretically provide increased stability by anchoring to the densest zone of the proximal humerus (subchondral zone) with the end of the nail. The aim of this study was to biomechanically investigate the characteristics of this "proximal anchoring point" (PAP). We hypothesized that the PAP would improve stability compared to the same construct without the PAP. Straight antegrade humeral nailing was performed in 20 matched pairs of human cadaveric humeri for a simulated unstable two-part fracture. Biomechanical testing, with stepwise increasing cyclic axial loading (50-N increments each 100 cycles) at an angle of 20° abduction revealed significantly higher median loads to failure for SAN constructs with the PAP (median, 450 N; range, 200-1.000 N) compared to those without the PAP (median, 325 N; range, 100-500 N; p = 0.009). SAN constructs with press-fit proximal extensions (endcaps) showed similar median loads to failure (median, 400 N; range, 200-650 N), when compared to the undersized, commercially available SAN endcaps (median, 450 N; range, 200-600 N; p = 0.240). The PAP provided significantly increased stability in SAN constructs compared to the same setup without this additional proximal anchoring point. Varus-displacing forces to the humeral head were superiorly reduced in this setting. This study provides biomechanical evidence for the "proximal anchoring point's" rationale. Straight antegrade humeral nailing may be beneficial for patients undergoing surgical treatment for unstable proximal humeral fractures to decrease secondary varus displacement and thus potentially reduce revision rates.

  9. Robotics in hostile environment I. S. I. S. robot - automatic positioning and docking with proximity and force feed back sensors

    Energy Technology Data Exchange (ETDEWEB)

    Gery, D

    1987-01-01

    Recent improvements in control command systems and the development of tactile proximity and force feed back sensors make it possible to robotize complex inspection and maintenance operations in hostile environment, which could have not been possible by classical remotely operated manipulators. We describe the I.S.I.S. robot characteristics, the control command system software principles and the tactile and force-torque sensors which have been developed for the different sequences of an hostile environment inspection and repair: access trajectories generation with obstacles shunning, final positioning and docking using parametric algorithms taking into account measurement of the end of arm proximity and force-torque sensors.

  10. Comparison of different proximity potentials for asymmetric colliding nuclei

    International Nuclear Information System (INIS)

    Dutt, Ishwar; Puri, Rajeev K.

    2010-01-01

    Using the different versions of phenomenological proximity potential as well as other parametrizations within the proximity concept, we perform a detailed comparative study of fusion barriers for asymmetric colliding nuclei with asymmetry parameter as high as 0.23. In all, 12 different proximity potentials are robust against the experimental data of 60 reactions. Our detailed study reveals that the surface energy coefficient as well as radius of the colliding nuclei depend significantly on the asymmetry parameter. All models are able to explain the fusion barrier heights within ±10% on the average. The potentials due to Bass 80, AW 95, and Denisov DP explain nicely the fusion cross sections at above- as well as below-barrier energies.

  11. High-throughput determination of RNA structure by proximity ligation.

    Science.gov (United States)

    Ramani, Vijay; Qiu, Ruolan; Shendure, Jay

    2015-09-01

    We present an unbiased method to globally resolve RNA structures through pairwise contact measurements between interacting regions. RNA proximity ligation (RPL) uses proximity ligation of native RNA followed by deep sequencing to yield chimeric reads with ligation junctions in the vicinity of structurally proximate bases. We apply RPL in both baker's yeast (Saccharomyces cerevisiae) and human cells and generate contact probability maps for ribosomal and other abundant RNAs, including yeast snoRNAs, the RNA subunit of the signal recognition particle and the yeast U2 spliceosomal RNA homolog. RPL measurements correlate with established secondary structures for these RNA molecules, including stem-loop structures and long-range pseudoknots. We anticipate that RPL will complement the current repertoire of computational and experimental approaches in enabling the high-throughput determination of secondary and tertiary RNA structures.

  12. Fractures of the proximal humerus involving the intertubercular groove

    International Nuclear Information System (INIS)

    Ahovuo, J.; Paavolainen, P.; Bjoerkenheim, J.M.; Helsinki Univ. Central Hospital

    1989-01-01

    The purpose of this study was to analyse the involvement of the gliding surface of the biceps tendon in fractures of the proximal humerus. Fifteen patients had a fracture of the proximal humerus verified with antero-posterior and axillary radiographs. Tangential radiographs of the intertubercular groove, obtained from the shoulder joint, showed involvement of the intertubercular groove in 13 patients (87%), which could not be shown with other projections. Groove radiographs revealed in 3 patients a dislocation of the fragments of the greater tuberosity large enough to require surgical treatment, but which had not been found using conventional techniques. Therefore, a groove radiograph should be used to precise fractures of the proximal humerus. (orig.)

  13. Clinical investigation of proximate exposed group, 1

    International Nuclear Information System (INIS)

    Ito, Chikako; Hasegawa, Kazuyo; Kato, Masafumi; Kumasawa, Toshihiko

    1984-01-01

    In order to investigate effects of the A-bombing on prevalence of diabetes mellitus, follow-up studies were made on 5907 A-bomb survivors who received glucose tolerance test (GTT) during 20 years between 1963 and 1983. The A-bomb survivors were divided into the group A (1899 men and 1165 women exposed within 1.9 km from the hypocenter) and the group B (1725 men and 1118 women exposed 3.0 km or farther from it). Among non-obese survivors, 21.9% and 21.8% were being treated for diabetes mellitus or were evaluated as having diabetic type on GTT in the group A and the group B, respectively; while this was seen in 52.1% of obese survivors in the group A and 49.9% in the group B. There was no difference between the groups. In non-obese survivors, the annual development rate from the normal type to the diabetic type was 0.89% in the group A and 0.65% in the group B; the annual development rate from the borderline type to the diabetic type was 5.73% in the group A and 5.49% in the group B, showing no differences between the groups. The annual development rate from the normal or borderline type to the diabetic type was two times or higher in obese survivors than in non-obese survivors irrespective of exposure status. Regarding the number of diabetic survivors who became non-diabetic type in spite of having no treatment, and prevalence of diabetic complications, no difference was seen between the groups. These results suggest that the A-bombing has scarcely influenced the prevalence of diabetes mellitus and clinical course. (Namekawa, K.)

  14. An anatomical study of the proximal aspect of the medial femoral condyle to define the proximal-distal condylar length

    Directory of Open Access Journals (Sweden)

    Chia-Ming Chang

    2017-01-01

    Full Text Available Objective: Despite its possible role in knee arthroplasty, the proximal-distal condylar length (PDCL of the femur has never been reported in the literature. We conducted an anatomic study of the proximal aspect of the medial femoral condyle to propose a method for measuring the PDCL. Materials and Methods: Inspection of dried bone specimens was carried out to assure the most proximal condylar margin (MPCM as the eligible starting point to measure the PDCL. Simulation surgery was performed on seven pairs of cadaveric knees to verify the clinical application of measuring the PDCL after locating the MPCM. Interobserver reliability of this procedure was also analyzed. Results: Observation of the bone specimens showed that the MPCM is a concavity formed by the junction of the distal end of the supracondylar ridge and the proximal margin of the medial condyle. This anatomically distinctive structure made the MPCM an unambiguous landmark. The cadaveric simulation surgical dissection demonstrated that the MPCM is easily accessed in a surgical setting, making the measurement of the PDCL plausible. The intraclass correlation coefficient was 0.78, indicating good interobserver reliability for this technique. Conclusion: This study has suggested that the PDCL can be measured based on the MPCM in a surgical setting. PDCL measurement might be useful in joint line position management, selection of femoral component sizes, and other applications related to the proximal-distal dimension of the knee. Further investigation is required.

  15. Morfología femoral proximal en fracturas de cadera

    OpenAIRE

    Calvo de Mora Rebollo, María Jesús; Albareda Albareda, Jorge Cruz; Seral García, Belén; Martín Ruiz, G.; Lasierra Sanromán, José Manuel; Seral Iñigo, Fernando

    2003-01-01

    Es frecuente observar como pacientes que han sufrido una fractura de cadera, si se fracturan posteriormente la cadera contralateral, es del mismo tipo que la primera fractura. El objetivo de este trabajo es tratar de relacional la morfología femoral proximal con la producción de un tipo determinado de fractura. Para ello hemos realizado un estudio prospectivo en 50 pacientes mayores de 65 años, sin distinción de sexo, que han ingresado en nuestro servicio por fractura femoral proximal, 25 ...

  16. True aneurysm of the proximal occipital artery: Case report.

    Science.gov (United States)

    Illuminati, Giulio; Cannistrà, Marco; Pizzardi, Giulia; Pasqua, Rocco; Frezzotti, Francesca; Calio', Francesco G

    2018-01-01

    True aneurysms of the proximal occipital artery are rare, may cause neurological symptoms due to compression of the hypoglossal nerve and their resection may be technically demanding. The case of an aneurysm of the proximal occipital artery causing discomfort and tongue deviation by compression on the hypoglossal nerve is reported. Postoperative course after resection was followed by complete regression of symptoms. Surgical resection, as standard treatment of aneurysms of the occipital artery, with the eventual technical adjunct of intubation by the nose is effective in durably relieving symptoms and preventing aneurysm-related complication. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

  17. True aneurysm of the proximal occipital artery: Case report

    Directory of Open Access Journals (Sweden)

    Giulio Illuminati

    Full Text Available Introduction: True aneurysms of the proximal occipital artery are rare, may cause neurological symptoms due to compression of the hypoglossal nerve and their resection may be technically demanding. Presentation of case: The case of an aneurysm of the proximal occipital artery causing discomfort and tongue deviation by compression on the hypoglossal nerve is reported. Postoperative course after resection was followed by complete regression of symptoms. Conclusion: Surgical resection, as standard treatment of aneurysms of the occipital artery, with the eventual technical adjunct of intubation by the nose is effective in durably relieving symptoms and preventing aneurysm-related complication. Keywords: Arterial aneurysm, Occipital artery, Case report

  18. Bizarre parosteal osteochondromatous proliferation of the proximal humerus: case report

    International Nuclear Information System (INIS)

    Bush, J.B.; Meyer, Mark S.; Reith, John D.

    2007-01-01

    Bizarre parosteal osteochondromatous proliferation (BPOP), or Nora's lesion, is a rare lesion of bone occurring predominantly in the long bones of the hands and feet. It exists as a puzzling clinical entity of uncertain origins and high recurrence rates after surgical resection. To our knowledge, this clinical entity has not been reported in the proximal aspect of the humerus. An interesting report of a lesion occurring in the proximal humerus, which initially was misinterpreted as a parosteal osteosarcoma, is discussed outlining the clinical, radiographic and pathologic features of the BPOP lesion. (orig.)

  19. Inter-proximal enamel reduction in contemporary orthodontics.

    Science.gov (United States)

    Pindoria, J; Fleming, P S; Sharma, P K

    2016-12-16

    Inter-proximal enamel reduction has gained increasing prominence in recent years being advocated to provide space for orthodontic alignment, to refine contact points and to potentially improve long-term stability. An array of techniques and products are available ranging from hand-held abrasive strips to handpiece mounted burs and discs. The indications for inter-proximal enamel reduction and the importance of formal space analysis, together with the various techniques and armamentarium which may be used to perform it safely in both the labial and buccal segments are outlined.

  20. Bizarre parosteal osteochondromatous proliferation of the proximal humerus: case report

    Energy Technology Data Exchange (ETDEWEB)

    Bush, J.B.; Meyer, Mark S. [Ochsner Clinic Foundation, Department of Orthopedics, New Orleans, LA (United States); Reith, John D. [University of Florida College of Medicine, Departments of Pathology, Immunology and Laboratory Medicine and Orthopaedics and Rehabilitation, Gainesville, Florida (United States)

    2007-06-15

    Bizarre parosteal osteochondromatous proliferation (BPOP), or Nora's lesion, is a rare lesion of bone occurring predominantly in the long bones of the hands and feet. It exists as a puzzling clinical entity of uncertain origins and high recurrence rates after surgical resection. To our knowledge, this clinical entity has not been reported in the proximal aspect of the humerus. An interesting report of a lesion occurring in the proximal humerus, which initially was misinterpreted as a parosteal osteosarcoma, is discussed outlining the clinical, radiographic and pathologic features of the BPOP lesion. (orig.)

  1. Identification of avascular necrosis in the dysplastic proximal femoral epiphysis

    International Nuclear Information System (INIS)

    Mandell, G.A.; Harcke, H.T.; MacKenzie, W.G.; Bassett, G.S.; Scott, C.I. Jr.; Wills, J.S.

    1989-01-01

    Bilateral radiographic irregularities and deformities of the proximal femoral epiphyses are features of both multiple epiphyseal dysplasia and bilateral idiopathic avascular necrosis. In the past these entities have been difficult to differentiate. This report documents radiographically the occurrence of avascular necrosis in 10 patients with multiple epiphyseal dysplasia by recognizing the superimposition of sclerosis and subchondral fissuring on pre-existing symmetrically irregular proximal femoral ossification centers. Scintigraphic (photopenia) or magnetic resonance (loss of signal) criteria of avascular necrosis confirm its added presence and help to establish an imaging scheme to identify avascular necrosis superimposed on multiple epiphyseal dysplasia. (orig.)

  2. Identification of avascular necrosis in the dysplastic proximal femoral epiphysis

    Energy Technology Data Exchange (ETDEWEB)

    Mandell, G A; Harcke, H T [Alfred I. duPont Inst., Wilmington, DE (USA). Dept. of Medical Imaging; MacKenzie, W G; Bassett, G S [Alfred I. duPont Inst., Wilmington, DE (USA). Dept. of Orthopaedics; Scott, Jr, C I [Alfred I. duPont Inst., Wilmington, DE (USA). Dept. of Genetics; Wills, J S [Medical Center of Delaware, Newark, DE (USA). Dept. of Radiology

    1989-07-01

    Bilateral radiographic irregularities and deformities of the proximal femoral epiphyses are features of both multiple epiphyseal dysplasia and bilateral idiopathic avascular necrosis. In the past these entities have been difficult to differentiate. This report documents radiographically the occurrence of avascular necrosis in 10 patients with multiple epiphyseal dysplasia by recognizing the superimposition of sclerosis and subchondral fissuring on pre-existing symmetrically irregular proximal femoral ossification centers. Scintigraphic (photopenia) or magnetic resonance (loss of signal) criteria of avascular necrosis confirm its added presence and help to establish an imaging scheme to identify avascular necrosis superimposed on multiple epiphyseal dysplasia. (orig.).

  3. Software Modules for the Proximity-1 Space Link Interleaved Time Synchronization (PITS) Protocol

    Science.gov (United States)

    Woo, Simon S.; Veregge, John R.; Gao, Jay L.; Clare, Loren P.; Mills, David

    2012-01-01

    The Proximity-1 Space Link Interleaved Time Synchronization (PITS) protocol provides time distribution and synchronization services for space systems. A software prototype implementation of the PITS algorithm has been developed that also provides the test harness to evaluate the key functionalities of PITS with simulated data source and sink. PITS integrates time synchronization functionality into the link layer of the CCSDS Proximity-1 Space Link Protocol. The software prototype implements the network packet format, data structures, and transmit- and receive-timestamp function for a time server and a client. The software also simulates the transmit and receive-time stamp exchanges via UDP (User Datagram Protocol) socket between a time server and a time client, and produces relative time offsets and delay estimates.

  4. A Tissue Propagation Model for Validating Close-Proximity Biomedical Radiometer Measurements

    Science.gov (United States)

    Bonds, Q.; Herzig, P.; Weller, T.

    2016-01-01

    The propagation of thermally-generated electromagnetic emissions through stratified human tissue is studied herein using a non-coherent mathematical model. The model is developed to complement subsurface body temperature measurements performed using a close proximity microwave radiometer. The model takes into account losses and reflections as thermal emissions propagate through the body, before being emitted at the skin surface. The derivation is presented in four stages and applied to the human core phantom, a physical representation of a stomach volume of skin, muscle, and blood-fatty tissue. A drop in core body temperature is simulated via the human core phantom and the response of the propagation model is correlated to the radiometric measurement. The results are comparable, with differences on the order of 1.5 - 3%. Hence the plausibility of core body temperature extraction via close proximity radiometry is demonstrated, given that the electromagnetic characteristics of the stratified tissue layers are known.

  5. Degree of proximity in the construction of social representations: the case of intelligence.

    Science.gov (United States)

    Miguel, Isabel; Valentim, Joaquim Pires; Carugati, Felice

    2012-11-01

    The present article is devoted to the empirical endeavor of studying the effect of the degree of proximity, defined by specific socio-educational insertions, on the organization of social representations of intelligence. A questionnaire was answered by a sample of 752 participants belonging to five different social categories with different degrees of proximity and knowledge about intelligence: mothers, fathers, mother-teachers and non-parent students (psychology and science students). The questionnaire included different topics, namely concerning the concept of intelligence, its development and the effectiveness of teaching procedures. Results show that the principles organizing the contents of representations are linked to the personal involvement in intelligence, on which subjects more or less implied take different positions. Results produced suggest, therefore, that the content of representations is directly linked to the activation of social roles and the salience of the object, reflecting the functional character that the organization of representations has to specific social dynamics.

  6. Research Techniques Made Simple: Emerging Methods to Elucidate Protein Interactions through Spatial Proximity.

    Science.gov (United States)

    Che, Yonglu; Khavari, Paul A

    2017-12-01

    Interactions between proteins are essential for fundamental cellular processes, and the diversity of such interactions enables the vast variety of functions essential for life. A persistent goal in biological research is to develop assays that can faithfully capture different types of protein interactions to allow their study. A major step forward in this direction came with a family of methods that delineates spatial proximity of proteins as an indirect measure of protein-protein interaction. A variety of enzyme- and DNA ligation-based methods measure protein co-localization in space, capturing novel interactions that were previously too transient or low affinity to be identified. Here we review some of the methods that have been successfully used to measure spatially proximal protein-protein interactions. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  7. Distributed fluorescent optical fiber proximity sensor: Towards a proof of concept

    Science.gov (United States)

    Gălătuș, Ramona; Faragó, Paul; Miluski, Piotr; Valles, Juan-Antonio

    2018-06-01

    Fluorescent fibers are optical fibers which emit light as a response to an incident phenomenon, usually an incident light. Operation depends on the doping dyes, which determine specific fluorescence and optical characteristics useful in the development of optical sensors. In this work we propose a low-cost distributed proximity sensor implemented using a red fluorescent fiber, to provide a security option for a surface plasmon resonance system. Operation of the proposed sensor relies on having the incident illumination intensity varied by the presence or absence of an obstacle in the vicinity of the sensing element. This will influence the radiated fluorescence accordingly. The proposed setup for the implementation of the optical proximity sensor assumes having a high brightness LED deployed for axial fiber illumination and a blue LED for side illumination. Electronic processing then accounts for gain and digitization. Measurement results of the prototype validate the proposed concept.

  8. Transparent and flexible cellulose nanocrystal/reduced graphene oxide film for proximity sensing.

    Science.gov (United States)

    Sadasivuni, Kishor Kumar; Kafy, Abdullahil; Zhai, Lindong; Ko, Hyun-U; Mun, Seongcheol; Kim, Jaehwan

    2015-02-25

    The rapid development of touch screens as well as photoelectric sensors has stimulated the fabrication of reliable, convenient, and human-friendly devices. Other than sensors that detect physical touch or are based on pressure sensing, proximity sensors offer controlled sensibility without physical contact. In this work we present a transparent and eco-friendly sensor made through layer-by-layer spraying of modified graphene oxide filled cellulose nanocrystals on lithographic patterns of interdigitated electrodes on polymer substrates, which help to realize the precise location of approaching objects. Stable and reproducible signals generated by keeping the finger in close proximity to the sensor can be controlled by humidity, temperature, and the distance and number of sprayed layers. The chemical modification and reduction of the graphene oxide/cellulose crystal composite and its excellent nanostructure enable the development of proximity sensors with faster response and higher sensitivity, the integration of which resolves nearly all of the technological issues imposed on optoelectronic sensing devices. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. A microcontroller-based compensated optical proximity detector employing the switching-mode synchronous detection technique

    International Nuclear Information System (INIS)

    Rakshit, Anjan; Chatterjee, Amitava

    2012-01-01

    This paper describes the development of a microcontroller-based optical proximity detector that can provide a low-cost yet powerful obstacle-sensing mechanism for mobile robots. The system is developed with the switching-mode synchronous detection technique to provide satisfactory performance over a wide range of operating conditions and is developed with the facility of externally setting a threshold, for reliable operation. The system is dynamically compensated against ambient illumination variations. Experimental studies demonstrate how the minimum distance of activation can be varied with different choices of thresholds. (paper)

  10. Augmented real-time navigation with critical structure proximity alerts for endoscopic skull base surgery.

    Science.gov (United States)

    Dixon, Benjamin J; Daly, Michael J; Chan, Harley; Vescan, Allan; Witterick, Ian J; Irish, Jonathan C

    2014-04-01

    Image-guided surgery (IGS) systems are frequently utilized during cranial base surgery to aid in orientation and facilitate targeted surgery. We wished to assess the performance of our recently developed localized intraoperative virtual endoscopy (LIVE)-IGS prototype in a preclinical setting prior to deployment in the operating room. This system combines real-time ablative instrument tracking, critical structure proximity alerts, three-dimensional virtual endoscopic views, and intraoperative cone-beam computed tomographic image updates. Randomized-controlled trial plus qualitative analysis. Skull base procedures were performed on 14 cadaver specimens by seven fellowship-trained skull base surgeons. Each subject performed two endoscopic transclival approaches; one with LIVE-IGS and one using a conventional IGS system in random order. National Aeronautics and Space Administration Task Load Index (NASA-TLX) scores were documented for each dissection, and a semistructured interview was recorded for qualitative assessment. The NASA-TLX scores for mental demand, effort, and frustration were significantly reduced with the LIVE-IGS system in comparison to conventional navigation (P < .05). The system interface was judged to be intuitive and most useful when there was a combination of high spatial demand, reduced or absent surface landmarks, and proximity to critical structures. The development of auditory icons for proximity alerts during the trial better informed the surgeon while limiting distraction. The LIVE-IGS system provided accurate, intuitive, and dynamic feedback to the operating surgeon. Further refinements to proximity alerts and visualization settings will enhance orientation while limiting distraction. The system is currently being deployed in a prospective clinical trial in skull base surgery. © 2013 The American Laryngological, Rhinological and Otological Society, Inc.

  11. Augmentation of proximal femoral nail in unstable trochanteric fractures

    Directory of Open Access Journals (Sweden)

    Gadegone Wasudeo M.

    2017-01-01

    Full Text Available Introduction: Biomechanically proximal femoral nail (PFN is a better choice of implant, still it is associated with screw breakage, cut out of screw through femoral head, Z effect, reverse Z effect, and lateral migration of screws. The purpose of this study is to evaluate the results of augmented PFN in terms of prevention of postoperative complications and failure rates in unstable trochanteric fractures. Material and methods: We carried out a prospective study of 82 cases with unstable trochanteric femoral fractures from April 2010 to December 2015. Forty-two females and 40 males in the age group between 58 and 81 years were included in this study. There were 45 cases of AO 31 A2 (2.2, 2.3 and 37 cases of AO 31 A3 (3.1, 3.2, 3.3. Fractures were fixed by PFN with augmentation by an additional screw from trochanter to inferior quadrant of femoral head or cerclage wire to strengthen the lateral trochanteric wall. Results: The bone healing is observed in all the cases in the mean period of 14.2 weeks. Nine patients developed complications, including lateral migration of neck screws (n = 5, Z effect (n = 1, infection (n = 2, and breakage of distal interlocking bolt in one case. Removal of screws was required in five cases. Patients were followed up for a mean of 8.4 months. At the end of follow-up the Salvati and Wilson hip function was 32 (out of 40 in 88% of patients. Conclusion: The stabilization of lateral trochanteric wall with additional screw or cerclage wire increases the stability of construct.

  12. Integrated model-based retargeting and optical proximity correction

    Science.gov (United States)

    Agarwal, Kanak B.; Banerjee, Shayak

    2011-04-01

    Conventional resolution enhancement techniques (RET) are becoming increasingly inadequate at addressing the challenges of subwavelength lithography. In particular, features show high sensitivity to process variation in low-k1 lithography. Process variation aware RETs such as process-window OPC are becoming increasingly important to guarantee high lithographic yield, but such techniques suffer from high runtime impact. An alternative to PWOPC is to perform retargeting, which is a rule-assisted modification of target layout shapes to improve their process window. However, rule-based retargeting is not a scalable technique since rules cannot cover the entire search space of two-dimensional shape configurations, especially with technology scaling. In this paper, we propose to integrate the processes of retargeting and optical proximity correction (OPC). We utilize the normalized image log slope (NILS) metric, which is available at no extra computational cost during OPC. We use NILS to guide dynamic target modification between iterations of OPC. We utilize the NILS tagging capabilities of Calibre TCL scripting to identify fragments with low NILS. We then perform NILS binning to assign different magnitude of retargeting to different NILS bins. NILS is determined both for width, to identify regions of pinching, and space, to locate regions of potential bridging. We develop an integrated flow for 1x metal lines (M1) which exhibits lesser lithographic hotspots compared to a flow with just OPC and no retargeting. We also observe cases where hotspots that existed in the rule-based retargeting flow are fixed using our methodology. We finally also demonstrate that such a retargeting methodology does not significantly alter design properties by electrically simulating a latch layout before and after retargeting. We observe less than 1% impact on latch Clk-Q and D-Q delays post-retargeting, which makes this methodology an attractive one for use in improving shape process windows

  13. Design of relative trajectories for in orbit proximity operations

    Science.gov (United States)

    Opromolla, Roberto; Fasano, Giancarmine; Rufino, Giancarlo; Grassi, Michele

    2018-04-01

    This paper presents an innovative approach to design relative trajectories suitable for close-proximity operations in orbit, by assigning high-level constraints regarding their stability, shape and orientation. Specifically, this work is relevant to space mission scenarios, e.g. formation flying, on-orbit servicing, and active debris removal, which involve either the presence of two spacecraft carrying out coordinated maneuvers, or a servicing/recovery spacecraft (chaser) performing monitoring, rendezvous and docking with respect to another space object (target). In the above-mentioned scenarios, an important aspect is the capability of reducing collision risks and of providing robust and accurate relative navigation solutions. To this aim, the proposed approach exploits a relative motion model relevant to two-satellite formations, and developed in mean orbit parameters, which takes the perturbation effect due to secular Earth oblateness, as well as the motion of the target along a small-eccentricity orbit, into account. This model is used to design trajectories which ensure safe relative motion, to minimize collision risks and relax control requirements, providing at the same time favorable conditions, in terms of target-chaser relative observation geometry for pose determination and relative navigation with passive or active electro-optical sensors on board the chaser. Specifically, three design strategies are proposed in the context of a space target monitoring scenario, considering as design cases both operational spacecraft and debris, characterized by highly variable shape, size and absolute rotational dynamics. The effectiveness of the proposed design approach in providing favorable observation conditions for target-chaser relative pose estimation is demonstrated within a simulation environment which reproduces the designed target-chaser relative trajectory, the operation of an active LIDAR installed on board the chaser, and pose estimation algorithms.

  14. [Proximal femoral fractures in the elderly: pathogenesis, sequelae, interventions].

    Science.gov (United States)

    Runge, M; Schacht, E

    1999-08-01

    Hip fractures are a health problem of paramount importance for the individual and society. They are associated with a sharp increase of the incidence of immobility, dependency, nursing home placement, and death. In Germany, more than 100,000 elderly suffer a hip fracture every year. 90% of fractures of the proximal femur result from a fall with an impact near the hip. The kinetic energy of a fall from standing height without successful protective reactions is far above the fracture threshold of a femur in a man aged 70 and older, regardless of osteoporosis and sex. Therefore, propensity to fall and mechanisms of falling are more important in the pathogenesis of hip fracture than bone mineral density alone. The combination of age-associated gait and balance disorders, which increase the probability of falls, and age-related decreasing strength of the femur is responsible for the high incidence of hip fractures. Besides the interventions to reduce the fall frequency it is possible to decrease the number of hip fractures by a passive protection of the trochanter. An energy-shunting protector (crash helmet-like, hip padding) has been developed by Lauritzen and Lund (safehip). The protector consists of two stiff shells, sewn into special undergarment. The shells disperse the impact away from the trochanter to soft tissue, and increase the area of contact. A controlled study among nursing home residents has demonstrated a relative risk of hip fracture of 0.44 (95% CC 0.21 to 0.94) in the intervention group, i.e., the protector has reduced the number of hip fractures by more than a half. No hip fracture has happened during use of the protector. Using the protector can improve self-confidence and diminish self-restraint of physical activity, which is not rarely caused by fear of falling. Further investigations of compliance are necessary.

  15. Demonstration of automated proximity and docking technologies

    Science.gov (United States)

    Anderson, Robert L.; Tsugawa, Roy K.; Bryan, Thomas C.

    An autodock was demonstrated using straightforward techniques and real sensor hardware. A simulation testbed was established and validated. The sensor design was refined with improved optical performance and image processing noise mitigation techniques, and the sensor is ready for production from off-the-shelf components. The autonomous spacecraft architecture is defined. The areas of sensors, docking hardware, propulsion, and avionics are included in the design. The Guidance Navigation and Control architecture and requirements are developed. Modular structures suitable for automated control are used. The spacecraft system manager functions including configuration, resource, and redundancy management are defined. The requirements for autonomous spacecraft executive are defined. High level decisionmaking, mission planning, and mission contingency recovery are a part of this. The next step is to do flight demonstrations. After the presentation the following question was asked. How do you define validation? There are two components to validation definition: software simulation with formal and vigorous validation, and hardware and facility performance validated with respect to software already validated against analytical profile.

  16. The Reliability of Classifications of Proximal Femoral Fractures with 3-Dimensional Computed Tomography: The New Concept of Comprehensive Classification

    Directory of Open Access Journals (Sweden)

    Hiroaki Kijima

    2014-01-01

    Full Text Available The reliability of proximal femoral fracture classifications using 3DCT was evaluated, and a comprehensive “area classification” was developed. Eleven orthopedists (5–26 years from graduation classified 27 proximal femoral fractures at one hospital from June 2013 to July 2014 based on preoperative images. Various classifications were compared to “area classification.” In “area classification,” the proximal femur is divided into 4 areas with 3 boundary lines: Line-1 is the center of the neck, Line-2 is the border between the neck and the trochanteric zone, and Line-3 links the inferior borders of the greater and lesser trochanters. A fracture only in the first area was classified as a pure first area fracture; one in the first and second area was classified as a 1-2 type fracture. In the same way, fractures were classified as pure 2, 3-4, 1-2-3, and so on. “Area classification” reliability was highest when orthopedists with varying experience classified proximal femoral fractures using 3DCT. Other classifications cannot classify proximal femoral fractures if they exceed each classification’s particular zones. However, fractures that exceed the target zones are “dangerous” fractures. “Area classification” can classify such fractures, and it is therefore useful for selecting osteosynthesis methods.

  17. Different mosaicism frequencies for proximal and distal Duchenne muscular dystrophy (DMD) mutations indicate difference in etiology and recurrence risk

    Energy Technology Data Exchange (ETDEWEB)

    Passos-Bueno, M.R.; Takata, R.I.; Rapaport, D.; Bakker, E.; Kneppers, A.L.J.; Dunnen, J.T. den; Ommen, J.B. van

    1992-11-01

    In about 65% of the cases of Duchenne muscular dystrophy (DMD) a partial gene deletion or duplication in the dystrophin gene can be detected. These mutations are clustered at two hot spots: 30% at the hot spot in the proximal part of the gene and about 70% at a more distal hot spot. Unexpectedly the authors observed a higher frequency of proximal gene rearrangements among proved germ line' mosaic cases. Of the 24 mosaic cases they are aware of, 19 (79%) have a proximal mutation, while only 5 (21%) have a distal mutation. This finding indicates that the mutations at the two hot spots in the dystrophin gene differ in origin. Independent support for the different mosaicism frequency was found by comparing the mutation spectra observed in isolated cases of DMD and familial cases (ratio 1:1). The authors conclude from these data that proximal deletions most likely occur early in embryonic development, causing them to have a higher chance of becoming familial, while distal deletions occur later and have a higher chance of causing only isolated cases. Finally, the findings have important consequences for the calculation of recurrence-risk estimates according to the site of the deletion: a [open quote]proximal[close quote] new mutant has an increased recurrence risk of approximately 30%, and a [open quote]distal[close quote] new mutant has a decreased recurrence risk of approximately 4%. 28 refs., 2 figs., 2 tabs.

  18. Flexible pressure and proximity sensor surfaces manufactured with organic materials

    NARCIS (Netherlands)

    Fattori, M.; Cantatore, E.; Pauer, G.; Agostinelli, T.; Stadlober, B.; Gold, H.

    2017-01-01

    This paper presents the design of two large-Area active matrixes on foil for pressure and proximity sensing applications. Frontend circuits based on organic thin-film transistors on foil are laminated with screen-printed PDVF-TrFE piezo and pyro sensors to create the complete flexible sensing

  19. Depressionary Effect of Proximity of Residential Properties to Waste ...

    African Journals Online (AJOL)

    Past studies have researched these impacts using a variety of hedonic models and Marginal Implicit Pricing, however, this study takes a special focus on the resident's perspective based on the linear proximity to waste disposal sites. 260 questionnaires were distributed to residents within 1km to the site and Estate ...

  20. Proximal onychomycosis due to Malassezia furfur: a case report

    Directory of Open Access Journals (Sweden)

    Zareei M

    2013-03-01

    Full Text Available Background: The etiologic role of Malassezia furfur in onychomycosis, because of its controversial keratinolytic ability, has not been proven. The most reported cases are distal subungual onychomycosis (DSO. In our knowledge no cases of proximal onychomycosis (PO has been reported. For the first time we report proximal onychomycosis. This case report describes the isolation of Malassezia furfur from fingernails. Case presentation: An Iranian 56- year- old women had been referred to mycology lab with hyperkeratosis in proximal regions of right hand nails and clinical diagnosis of onychomycosis without paronychia in May 2012. She used several medicines for her cardiac disease, mental illness, severe stress and blood glucose fluctuation diseases. Scraping and sampling from nail lesions were done, budding yeast cells with broadband connections were observed in 15% KOH wet mounts. Also, other differentiation tests, consist of staining with methylen blue, cultures and biochemical tests were done. In order to rejecting the probable etiologic role of any dermatophytic or non-dermatophytic fungi in this case, samples were collected from other parts of the body by scotch tape and scraping with scalpel blade too, but the results of direct microscopy and culture were negative. Finally, Malassezia furfur was identified as the causative agent of onychomycosis.Conclusion: Despite failure to prove Malassezia furfur keratinolytic ability, it can be the etiologic agent of proximal onychomycosis that shows the aggressive properties of this species. Its clinical importance is the easier transmission to hospitalized patients and other people.

  1. Proximate and Cholesterol Composition of Selected Fast Foods ...

    African Journals Online (AJOL)

    Fast foods consumption has been on the increase in Nigeria raising concerns about the nutritional and health implications. This study was carried out to determine the proximate composition and cholesterol contents of four commonly consumed fast foods (doughnut, chicken pie, roasted chicken, and Jollof rice) sold in ...

  2. Proximate and mineral elements composition of five locally ...

    African Journals Online (AJOL)

    The proximate composition of the studied fruits were determined by the standard methods of Official Analytical Chemists, while the Mineral Elements (Ca and Mg) were analyzed using Atomic Absorption Spectrophotometry. The levels of Na+ and K+ were determined using Flame photometry and the level of P was ...

  3. Proximal tibiofibular dislocation: a case report and review of literature

    NARCIS (Netherlands)

    Nieuwe Weme, R. A.; Somford, M. P.; Schepers, T.

    2014-01-01

    An isolated dislocation of the proximal tibiofibular joint is uncommon. The mechanism of this injury is usually sports related. We present a case where initial X-rays did not show the tibiofibular joint dislocation conclusively. It was diagnosed after comparative bilateral AP X-rays of the knees

  4. Proximate, phytochemical and mineral compositions of seeds of ...

    African Journals Online (AJOL)

    ALLSWELL

    2012-06-21

    Jun 21, 2012 ... Evaluation of the proximate, phytochemical and mineral compositions of seeds of three tree species was carried out at the University of Agriculture, Umudike. Mature fruits of Allanblackia floribunda,. Garcinia kola and Poga oleosa were collected from the rainforest at Umudike and Oban National Park.

  5. Better access to microcredits: does geographical proximity matter?

    Czech Academy of Sciences Publication Activity Database

    Alimukhamedova, Nargiza

    -, 2013/2014 Winter (2014), s. 24-25 Institutional support: PRVOUK-P23 Keywords : microcredits * geographical proximity Subject RIV: AH - Economics http://www.e-mfp.eu/sites/ default /files/resources/2014/02/e-MFP_Winter2013-2014_Newsletter%20.pdf

  6. Changes in proximate and phytochemical compositions of Persea ...

    African Journals Online (AJOL)

    Persea americana (avocado pear leaves, fruits, and seeds) is one of the medicinal herbs that has been widely utilized in treating/managing disease conditions. In this study, we investigated the changes in proximate and phytochemical compositions of avocado seeds associated with ripening using standard methods.

  7. Proximate, mineral and vitamin C composition of vegetable Gbolo ...

    African Journals Online (AJOL)

    Gbolo (Crassocephalum crepidioides and Crassocephalum rubens) is a traditional leafy vegetable highly consumed in southern and central Benin, as well as in some part of northern Benin. The nutritional potential of the two species of Gbolo were evaluated through their proximate composition, mineral and vitamin C ...

  8. Proximity effect in normal metal-multiband superconductor hybrid structures

    NARCIS (Netherlands)

    Brinkman, Alexander; Golubov, Alexandre Avraamovitch; Kupriyanov, M. Yu

    2004-01-01

    A theory of the proximity effect in normal metal¿multiband superconductor hybrid structures is formulated within the quasiclassical Green's function formalism. The quasiclassical boundary conditions for multiband hybrid structures are derived in the dirty limit. It is shown that the existence of

  9. User's proximity effects for talk mode in mobile phones

    DEFF Research Database (Denmark)

    Pelosi, Mauro; B. Knudsen, Mikael; Pedersen, Gert Frølund

    Thanks to a recent grip study, 3D CAD model of the human hand have been generated, investigating user's proximity effects for talk mode in mobile phones. The simulation results show that the human hand exhibits a major contribution in determining the total loss when compared to the phantom head...

  10. Heavy metal and proximate composition associated with the ...

    African Journals Online (AJOL)

    Changes in the heavy metal content and proximate composition during the 28 day composting of cassava peels used in the cultivation of the oyster mushrooms Pleurotus ostreatus strain EM-1 was studied. Significant dry weight variations of cellulose, hemicellulose and fat contents were observed from day 0 to 12.

  11. Proximate composition and mineral profile of eight different ...

    African Journals Online (AJOL)

    ... eight different sun dried date varieties; (1) Daki, (2) Aseel, (3) Coconut, (4) Khuzravi, (5) Halavi, (6) Zahidi, (7) Deglet Noor and (8) Barkavi were examined to determine their proximate composition and mineral profile. All the date varieties were found to be rich in proteins, fiber, carbohydrates and net gross energy (352.329 ...

  12. Proximate analysis of Sweet Potato Toasted Granules | Meludu ...

    African Journals Online (AJOL)

    Sweet potato is an important root crop in the food system of many African countries. The yield, nutrition and economic potential of sweet potato have been identified as very high. In this study, sweet potato was processed and toasted into granules. The proximate analysis performed on the toasted granules showed protein, ...

  13. Correction of Misclassifications Using a Proximity-Based Estimation Method

    Directory of Open Access Journals (Sweden)

    Shmulevich Ilya

    2004-01-01

    Full Text Available An estimation method for correcting misclassifications in signal and image processing is presented. The method is based on the use of context-based (temporal or spatial information in a sliding-window fashion. The classes can be purely nominal, that is, an ordering of the classes is not required. The method employs nonlinear operations based on class proximities defined by a proximity matrix. Two case studies are presented. In the first, the proposed method is applied to one-dimensional signals for processing data that are obtained by a musical key-finding algorithm. In the second, the estimation method is applied to two-dimensional signals for correction of misclassifications in images. In the first case study, the proximity matrix employed by the estimation method follows directly from music perception studies, whereas in the second case study, the optimal proximity matrix is obtained with genetic algorithms as the learning rule in a training-based optimization framework. Simulation results are presented in both case studies and the degree of improvement in classification accuracy that is obtained by the proposed method is assessed statistically using Kappa analysis.

  14. Studies on the proximate composition, functional properties and ...

    African Journals Online (AJOL)

    The present study produced full fat and defatted flours from matured ackee apple arils and evaluated the proximate composition and the effect of pH and salt concentrations on some of the functional properties of the full fat flour and the defatted flour. Matured ackee apple arils were oven-dried at 60 oC and milled to obtain ...

  15. Effect of drought/irrigation on proximate composition and ...

    African Journals Online (AJOL)

    Enset [Ensete ventricosum (Welw.) Cheesman] is an important root crop serving as a carbohydrate rich food source in Ethiopia. Perennial crops, like enset, are often exposed to recurrent dry periods which could greatly affect their growth, physiology and yield. The effect of induced drought/irrigation on the proximate ...

  16. Proximate composition and amino acid profile of rice husk ...

    African Journals Online (AJOL)

    Native rice husk (NRH) was fermented with Pleurotus ostreatus for 7, 14 and 21 days to improve the nutritional values. The proximate composition and amino acid profiles were determined. The results showed that crude fibre (CF), nitrogen free extract (NFE), acid detergent fibre (ADF), and neutral detergent fibre (NDF) were ...

  17. Proximate, phytochemical and mineral compositions of seeds of ...

    African Journals Online (AJOL)

    Evaluation of the proximate, phytochemical and mineral compositions of seeds of three tree species was carried out at the University of Agriculture, Umudike. Mature fruits of Allanblackia floribunda, Garcinia kola and Poga oleosa were collected from the rainforest at Umudike and Oban National Park. The seeds were ...

  18. Microbiological, proximate analysis and sensory evaluation of baked ...

    African Journals Online (AJOL)

    The possibility of making bread of good nutritional, microbiological and sensory qualities from blends of wheat-breadfruit flours was examined. Blends of wheat flour (WF) with percentages of 0, 5, 10, 15, 20 and 25 of breadfruits flour (BF) were used in the production process. The proximate analysis, sensory evaluation and ...

  19. Proximate composition and phytochemistry of seed oil five cultivars ...

    African Journals Online (AJOL)

    Proximate composition and phytochemistry of seed oil five cultivars of Cajanus cajan in Nigeria. BA Iwalokun, OJ Adeyemi, TI Adeleke, EO Abayomi. Abstract. No Abstract. Nigerian Food Journal Vol. 24(1) 2006: 50-60. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT.

  20. Residential proximity to gasoline service stations and preterm birth.

    Science.gov (United States)

    Huppé, Vicky; Kestens, Yan; Auger, Nathalie; Daniel, Mark; Smargiassi, Audrey

    2013-10-01

    Preterm birth (PTB) is a growing public health problem potentially associated with ambient air pollution. Gasoline service stations can emit atmospheric pollutants, including volatile organic compounds potentially implicated in PTB. The objective of this study was to evaluate the relationship between residential proximity to gasoline service stations and PTB. Singleton live births on the Island of Montreal from 1994 to 2006 were obtained (n=267,478). Gasoline service station locations, presence of heavy-traffic roads, and neighborhood socioeconomic status (SES) were determined using a geographic information system. Multivariable logistic regression was used to analyze the association between PTB and residential proximity to gasoline service stations (50, 100, 150, 200, 250, and 500 m), accounting for maternal covariates, neighborhood SES, and heavy-traffic roads. For all distance categories beyond 50 m, presence of service stations was associated with a greater odds of PTB. Associations were robust to adjustment for maternal covariates for distance categories of 150 and 200 m but were nullified when adjusting for neighborhood SES. In analyses accounting for the number of service stations, the likelihood of PTB within 250 m was statistically significant in unadjusted models. Associations were, however, nullified in models accounting for maternal covariates or neighborhood SES. Our results suggest that there is no clear association between residential proximity to gasoline service stations in Montreal and PTB. Given the correlation between proximity of gasoline service stations and SES, it is difficult to delineate the role of these factors in PTB.

  1. Phytochemical, Proximate and Metal Content Analysis of the Leaves ...

    African Journals Online (AJOL)

    Methods: The phytochemical analysis of Psidium guajava was carried out by using a standard procedure. Ash, fat, protein, carbohydrate and fibre contents were determined using proximate analysis while the metal contents were determined using Pearson's method. Results: The phytochemical analysis revealed the ...

  2. Proximate composition and sensory properties of freeze-dried ...

    African Journals Online (AJOL)

    These instant soups and the freshly prepared portions were subjected to proximate and sensory analysis using standard methods. The results of the analysis showed that instant egusi soup contained 10.89 % moisture, 16.93 % ash, 19.73 % crude protein, 15.19 % fat, 13.95 % crude fibre and 23.30 % carbohydrate; while ...

  3. Comparative analysis of the Proximate composition and Sensory ...

    African Journals Online (AJOL)

    Proximate analysis of the samples revealed that the protein, fat, ash, crude fibre and acid insoluble ash contents differed significantly (p<0.05) between samples. With respect to protein and fat contents, dokuwa sample from Doko had the highest values while dokuwa sample from Lapai had the lowest but the reverse was ...

  4. Heavy metal, proximate and microbial profile of some selected ...

    African Journals Online (AJOL)

    The study on the elemental, proximate and microbial composition of fresh samples of Scomber scombrus, Gadus macrocephalus, Saclina pilchradus and Jack mackerel was determined to gain the knowledge of the risk and benefits associated with indiscriminate consumption of marine fishes. Wet digestion was done for the ...

  5. Microbiological and proximate analyses of unripened cheese 'Wara ...

    African Journals Online (AJOL)

    ... may be attributed to poor hygiene of the handlers and manufacturing practices. A careful appraisal of these procedures and the use of pasteurized milk is suggested to reduce the exposure of consumers to health hazard. Key words: Raw milk, Pathogens, Coliforms, Cheese, food borne pathogens, Proximate composition.

  6. Proximate Analysis And The Determination Of Some Physico ...

    African Journals Online (AJOL)

    ... Mg (296.00-371.50 µg/g) and Ca (1165.00-1335.50 µg/g) with few exceptions. The results obtained show good agreement with literature values and provide information on the nutritional value of some of the common evaporated milks sold on Nigerian markets. Keywords: Milk, proximate analysis, physico-chemical, AAS

  7. Performance characteristics of proximity focused ultraviolet image converters

    Science.gov (United States)

    Williams, J. T.; Feibelman, W. A.

    1973-01-01

    Performance characteristics of Bendix type BX 8025-4522 proximity focused image tubes for UV to visible light conversion are presented. Quantum efficiency, resolution, background, geometric distortion, and environmental test results are discussed. The converters use magnesium fluoride input windows with Cs-Te photocathodes and P-11 phosphors on fiber optic output windows.

  8. Proximate and mineral analysis of some wild edible mushrooms

    African Journals Online (AJOL)

    israelikk

    2012-04-12

    Apr 12, 2012 ... Key words: Edible mushroom, mineral composition, proximate analysis. ... than beef, pork and chicken that contain similar nutrients. .... legumes and meat. In earlier studies, Gruen and Wong. (1982) indicated that edible mushrooms were highly nutritional and compared favourably with meat, egg and milk.

  9. Proximate analysis of Lentinus squarrosulus (Mont.) Singer and ...

    African Journals Online (AJOL)

    hope&shola

    Lentinus squarrosulus and Psathyrella atroumbonata, two mushroom species commonly found growing on dead leaves and logs, were collected from the Zaria environ and taken to the laboratory for further studies. Each of the mushroom species was separated into its stipe and pileus and used for proximate analysis.

  10. Leveraging Proximity Sensing to Mine the Behavior of Museum Visitors

    NARCIS (Netherlands)

    Martella, Claudio; Miraglia, Armando; Cattani, Marco; van Steen, Martinus Richardus

    Face-to-face proximity has been successfully leveraged to study the relationships between individuals in various contexts, from a working place, to a conference, a museum, a fair, and a date. We spend time facing the individuals with whom we chat, discuss, work, and play. However, face-to-face

  11. Proximate composition of Mystus bleekeri in relation to body size ...

    African Journals Online (AJOL)

    Proximate composition of small catfish, Mystus bleekeri, from Nala Daik, Sialkot, Pakistan was investigated and fluctuation in relation to body size and condition factor was carried out. Mean percentages for water, fat, protein and ash contents in the whole wet body weight of wild M. bleekeri were 77.87, 3.26, 15.01 and ...

  12. Percutaneous transluminal angioplasty of stenoses of the proximal subclavian artery

    International Nuclear Information System (INIS)

    Grote, R.; Freyschmidt, J.; Walterbusch, G.; Medizinische Hochschule Hannover

    1983-01-01

    Between August 1980 and June 1982, 12 left-sided proximal subclavian stenoses were dilated with balloon catheters. The dilatation was successful in all patients. Differences in blood pressure in the arm could be demonstrated subsequently. Recurrences occurred in two patients after seven and eleven months. Follow-up of nine patients up to 24 months showed them to be symptom-free. (orig.)

  13. Effect of thermal processing methods on the proximate composition ...

    African Journals Online (AJOL)

    The nutritive value of raw and thermal processed castor oil seed (Ricinus communis) was investigated using the following parameters; proximate composition, gross energy, mineral constituents and ricin content. Three thermal processing methods; toasting, boiling and soaking-and-boiling were used in the processing of the ...

  14. Predicting Performance in Higher Education Using Proximal Predictors

    NARCIS (Netherlands)

    Niessen, A Susan M; Meijer, Rob R; Tendeiro, Jorge N

    2016-01-01

    We studied the validity of two methods for predicting academic performance and student-program fit that were proximal to important study criteria. Applicants to an undergraduate psychology program participated in a selection procedure containing a trial-studying test based on a work sample approach,

  15. Phytochemical, proximate and anti-nutrient compositions of four ...

    African Journals Online (AJOL)

    Chemical constituents of plants are influenced by environmental factors and fluctuations just as many other polygenic traits. Four different green leafy vegetables commonly used in the diets of South Eastern Nigeria were analyzed with a view to determine the phytochemicals, proximate and anti-nutrient compositions of ...

  16. Using an index of habitat patch proximity for landscape design

    Science.gov (United States)

    Eric J. Gustafson; George R. Parker

    1994-01-01

    A proximity index (PX) inspired by island biogeography theory is described which quantifies the spatial context of a habitat patch in relation to its neighbors. The index distinguishes sparse distributions of small habitat patches from clusters of large patches. An evaluation of the relationship between PX and variation in the spatial characteristics of clusters of...

  17. Affordable dual-sensing proximity sensor for touchless interactive systems

    KAUST Repository

    Nassar, Joanna M.; Diaz, Marlon C.; Hussain, Muhammad Mustafa

    2016-01-01

    We report an ultra-low cost flexible proximity sensor using only off-the-shelf recyclable materials such as aluminum foil, napkin and double-sided tape. Unlike previous reports, our device structure exhibits two sensing capabilities in one platform

  18. Innervation of the renal proximal convoluted tubule of the rat

    International Nuclear Information System (INIS)

    Barajas, L.; Powers, K.

    1989-01-01

    Experimental data suggest the proximal tubule as a major site of neurogenic influence on tubular function. The functional and anatomical axial heterogeneity of the proximal tubule prompted this study of the distribution of innervation sites along the early, mid, and late proximal convoluted tubule (PCT) of the rat. Serial section autoradiograms, with tritiated norepinephrine serving as a marker for monoaminergic nerves, were used in this study. Freehand clay models and graphic reconstructions of proximal tubules permitted a rough estimation of the location of the innervation sites along the PCT. In the subcapsular nephrons, the early PCT (first third) was devoid of innervation sites with most of the innervation occurring in the mid (middle third) and in the late (last third) PCT. Innervation sites were found in the early PCT in nephrons located deeper in the cortex. In juxtamedullary nephrons, innervation sites could be observed on the PCT as it left the glomerulus. This gradient of PCT innervation can be explained by the different tubulovascular relationships of nephrons at different levels of the cortex. The absence of innervation sites in the early PCT of subcapsular nephrons suggests that any influence of the renal nerves on the early PCT might be due to an effect of neurotransmitter released from renal nerves reaching the early PCT via the interstitium and/or capillaries

  19. Beyond proximities : The socio-spatial dynamics of knowledge creation

    NARCIS (Netherlands)

    Rutten, R.P.J.H.

    2017-01-01

    Knowledge creation is recognized as interaction between individuals in a social context, but geography-of-knowledge-creation research inadequately connects social context to physical place. The proximities approach reduces physical place to near-far dichotomies and territorial innovation models

  20. The use of pedicled prepucial skin flap urethroplasty for proximal ...

    African Journals Online (AJOL)

    The use of pedicled prepucial skin flap urethroplasty for proximal bulbomembraneous urethral stricture in children: an easy alternative to transpubic urethroplasty. Harshjeet S. Bal, Jujju J. Kurian and Sudipta Sen. Objective Pediatric urethral strictures are not uncommon, and a myriad of treatment options is available.

  1. Worlds largest particle physics laboratory selects Proxim Wireless Mesh

    CERN Multimedia

    2007-01-01

    "Proxim Wireless has announced that the European Organization for Nuclear Research (CERN), the world's largest particle physics laboratory and the birthplace of the World Wide Web, is using it's ORiNOCO AP-4000 mesh access points to extend the range of the laboratory's Wi-Fi network and to provide continuous monitoring of the lab's calorimeters" (1/2 page)

  2. Proximity effects of high voltage electric power transmission lines on ...

    African Journals Online (AJOL)

    The proximity effects of high voltage electric power transmission lines on Leyland Cypress (xCupressocyparis leylandii (Dallim. and A.B. Jacks.) Dallim) and Japanese Privet (Ligustrum japonicum Thunb.) growth were examined in a private nursery located in Sakarya, Turkey. Five transect were randomly chosen in both ...

  3. Effects of fermentation and extrusion on the proximate composition ...

    African Journals Online (AJOL)

    The effect of extrusion and fermentation on the proximate composition and organoleptic properties of six combinations (100:0, 90:10, 80:20, 70:30, 60:40 and 50:50) of sorghum - soya blend were investigated. A total number of 19 microorganisms were isolated during the fermentation of sorghum-soya extrudates; these ...

  4. Phytochemical and proximate analysis of Aspillia kotschyi (Sch ...

    African Journals Online (AJOL)

    The phytochemical and proximate composition of Aspillia Kotschyi belonging to Compositae family which is commonly used as medicinal plant in Nigeria was determined on both the Methanolic and Petroleum spirit extracts of the plant material The Methanolic extract of the plant revealed the presence of carbohydrates, ...

  5. Effect of drying temperatures on the proximate composition and ...

    African Journals Online (AJOL)

    Results of the proximate composition showed that the nutritional qualities of the dried eggs were retained during drying thus the drying temperature did not affect the quality of eggs. The moisture contents of the dried whole egg, dried egg yolk and dried egg white at the different temperatures range from 6.25 -7.23%, ...

  6. Impact of Relational Proximity on Distress from Infidelity

    NARCIS (Netherlands)

    Fisher, Maryanne; Geher, Glenn; Cox, Anthony; Tran, Ulrich S.; Hoben, Ashley; Arrabaca, Andrew; Chaize, Corinna; Dietrich, Robert; Voracek, Martin

    2009-01-01

    Men are generally more distressed by a partner's sexual infidelity whereas women are generally more distressed by a partner's emotional infidelity. The importance of the identity of the interloper, however, has been neglected. We explored the influence of relational proximity (i.e., the degree of

  7. A security review of proximity identification based smart cards

    CSIR Research Space (South Africa)

    Lefophane, S

    2015-03-01

    Full Text Available International Conference on Cyber warfare and Security, Mpumalanga, Kruger National Park, South Africa, 24-25 March 2015 A SECURITY REVIEW OF PROXIMITY IDENTIFICATION BASED SMART CARDS S.Lefophane, J. Van der Merwe Modelling and Digital Science: CSIR...

  8. Effect of Soaking Time on Proximate and Mineral Compositions and ...

    African Journals Online (AJOL)

    Effect of soaking time on some composition of yellow maize was investigated. Yellow maize seeds (Zea mays) were soaked in deionized water for 12, 24, 36 and 48 hours respectively followed by draining, drying and milling. The unsoaked seeds were milled and served as the control. Proximate and mineral compositions ...

  9. The Grammaticalization of the Proximative in Tok Pisin.

    Science.gov (United States)

    Romaine, Suzanne

    1999-01-01

    Discusses grammaticalization of "laik" in Tok Pisin, meaning "want/like/desire" (from English "like") and "klostu," meaning "near" (from English "close to") as markers of proximative. Shows although "klostu" was more generally a feature of Pacific Pidgin English and began to…

  10. Age factor and proximate compositions of the muscle of ...

    African Journals Online (AJOL)

    Significant increases (P < 0.05) in the nitrogen free extract (NFE) of the fish muscle might have been due to the high energy demand imposed on the fish as a positive survival value under the condition of crude oil stress. Keywords: Heterobranchus bidorsalis, Age groups, Proximate composition, Bonny-light crude oil, ...

  11. A STUDY ON PROXIMAL HUMERAL FRACTURES STABILISED WITH PHILOS PLATE

    Directory of Open Access Journals (Sweden)

    Praveen Sivakumar K

    2017-02-01

    Full Text Available BACKGROUND Techniques for treating complex proximal humeral fractures vary and include fixations using tension bands, percutaneous pins, bone suture, T-plates, intramedullary nails, double tubular plates, hemiarthroplasty, plant tan humerus fixator plates, Polaris nails and blade plates. Complications of these techniques include cutout or back out of the screws and plates, avascular necrosis, nonunion, malunion, nail migration, rotator cuff impairment and impingement syndromes. Insufficient anchorage from conventional implants may lead to early loosening and failure, especially in osteoporotic bones. In general, nonoperative treatment of displaced three and four-part fractures of the proximal humerus leads to poor outcome due to intraarticular nature of injury and inherent instability of the fragments. Comminuted fractures of the proximal humerus are at risk of fixation failure, screw loosening and fracture displacement. Open reduction and internal fixation with conventional plate and screws has been associated with unacceptably high incidence of screw pull out. PHILOS (the proximal humeral internal locking system plate is an internal fixation system that enables angled stabilisation with multiple interlocking screws for fractures of the proximal humerus. MATERIALS AND METHODS 30 patients with proximal humerus fractures who were admitted in the Department of Orthopaedics, Government General Hospital, Kakinada, during the period November 2014 - November 2016 were taken up for study according to inclusion criteria. All patients were treated with PHILOS plate. These proximal humerus fractures were classified according to Neer’s classification. Patients were followed up at 6 weeks, 12 weeks and 6 months’ interval. Functional outcomes for pain, range of motion and muscle power and function were assessed using the Constant-Murley scoring system. Collected data analysed with independent t-test and ANNOVA test. RESULTS The outcome of the study was 1

  12. Musicians' and nonmusicians' short-term memory for verbal and musical sequences: comparing phonological similarity and pitch proximity.

    Science.gov (United States)

    Williamson, Victoria J; Baddeley, Alan D; Hitch, Graham J

    2010-03-01

    Language-music comparative studies have highlighted the potential for shared resources or neural overlap in auditory short-term memory. However, there is a lack of behavioral methodologies for comparing verbal and musical serial recall. We developed a visual grid response that allowed both musicians and nonmusicians to perform serial recall of letter and tone sequences. The new method was used to compare the phonological similarity effect with the impact of an operationalized musical equivalent-pitch proximity. Over the course of three experiments, we found that short-term memory for tones had several similarities to verbal memory, including limited capacity and a significant effect of pitch proximity in nonmusicians. Despite being vulnerable to phonological similarity when recalling letters, however, musicians showed no effect of pitch proximity, a result that we suggest might reflect strategy differences. Overall, the findings support a limited degree of correspondence in the way that verbal and musical sounds are processed in auditory short-term memory.

  13. Physical, proximate, functional and pasting properties of flour produced from gamma irradiated cowpea (Vigna unguiculata, L. Walp)

    Science.gov (United States)

    Darfour, B.; Wilson, D. D.; Ofosu, D. O.; Ocloo, F. C. K.

    2012-04-01

    Cowpeas are leguminous seeds widely produced and consumed in most developing countries of sub Saharan Africa. The aim of this study was to determine the physical, proximate, functional and pasting properties of flour obtained from gamma irradiated cowpea. Four cowpea cultivars were irradiated with gamma radiation at dose levels of 0.25, 0.5, 0.75, 1.0 and 1.5 kGy with the unirradiated cultivars serving as controls. The samples were hammer milled, sieved and stored at 4 °C for analysis. Physical, proximate, functional, pasting properties were determined using appropriate methods. In general, the irradiation dose applied to cowpea for insect control did not significantly affect the physical and proximate properties of the flour. However, significant increase (pcowpea affected both the functional and pasting properties of the flour.

  14. Common iliac vein thrombosis as a result of proximal venous stenosis following renal transplantation: A case report

    Directory of Open Access Journals (Sweden)

    Atish Chopra

    2016-12-01

    Full Text Available Proximal iliac vein stenosis resulting in iliac vein thrombus and venous outflow obstruction in renal transplant patients is an exceedingly rare occurrence. We present a case of a 63-year-old male who underwent deceased donor renal transplantation and presented 12 days later with ipsilateral lower extremity swelling and plateauing serum creatinine. Further work-up demonstrated proximal iliac vein deep venous thrombosis and anticoagulation was initiated. However, propagation of the thrombus developed despite receiving therapeutic anticoagulation. Subsequent venography demonstrated proximal iliac venous stenosis and the patient underwent successful catheter-directed alteplase thrombolysis, inferior vena cava filter placement and iliac vein stenting with salvage of the renal allograft. A diagnostic strategy and management algorithm for iliac vein stenosis and thrombosis in a renal transplant recipient is proposed.

  15. Biomechanical Strength of Retrograde Fixation in Proximal Third Scaphoid Fractures.

    Science.gov (United States)

    Daly, Charles A; Boden, Allison L; Hutton, William C; Gottschalk, Michael B

    2018-04-01

    Current techniques for fixation of proximal pole scaphoid fractures utilize antegrade fixation via a dorsal approach endangering the delicate vascular supply of the dorsal scaphoid. Volar and dorsal approaches demonstrate equivalent clinical outcomes in scaphoid wrist fractures, but no study has evaluated the biomechanical strength for fractures of the proximal pole. This study compares biomechanical strength of antegrade and retrograde fixation for fractures of the proximal pole of the scaphoid. A simulated proximal pole scaphoid fracture was produced in 22 matched cadaveric scaphoids, which were then assigned randomly to either antegrade or retrograde fixation with a cannulated headless compression screw. Cyclic loading and load to failure testing were performed and screw length, number of cycles, and maximum load sustained were recorded. There were no significant differences in average screw length (25.5 mm vs 25.6 mm, P = .934), average number of cyclic loading cycles (3738 vs 3847, P = .552), average load to failure (348 N vs 371 N, P = .357), and number of catastrophic failures observed between the antegrade and retrograde fixation groups (3 in each). Practical equivalence between the 2 groups was calculated and the 2 groups were demonstrated to be practically equivalent (upper threshold P = .010). For this model of proximal pole scaphoid wrist fractures, antegrade and retrograde screw configuration have been proven to be equivalent in terms of biomechanical strength. With further clinical study, we hope surgeons will be able to make their decision for fixation technique based on approaches to bone grafting, concern for tenuous blood supply, and surgeon preference without fear of poor biomechanical properties.

  16. Surgical treatment of proximal humerus fractures using PHILOS plate

    Directory of Open Access Journals (Sweden)

    Vijay Sharma

    2014-10-01

    Full Text Available 【Abstract】Objective: To evaluate functional outcome and complications of open reduction and internal fixation with proximal humeral internal locking system (PHILOS plate for proximal humerus fractures. Methods: We reviewed 51 patients who underwent open reduction and internal fixation with PHILOS plate between the years 2007 to 2012. There were 35 men and 16 women with a mean age of 38 years (range 24-68. There were 41 patients in the age group of <60 years and 10 patients in the age group of >60 years. According to Neer classification system, 8, 15 and 23 patients had 2-part, 3-part, and 4-part fractures, respectively and 5 patients had 4-part fracture dislocation. All surgeries were carried out at our tertiary care trauma centre. Functional evaluation of the shoulder at final follow-up was done using Constant-Murley score. Results: The mean follow-up period was 30 months (range 12-44 months. Two patients were lost to followup. Of the remaining 49 patients, all fractures were united clinically and radiologically. The mean time for radiological union was 12 weeks (range 8-20 weeks. At the final follow-up the mean Constant-Murley score was 79 (range 50-100. The results were excellent in 25 patients, good in 13 patients, fair in 6 atients and poor in 5 patients. During the follow-up, four cases of varus malunion, one case of subacromial impingement, one case of deep infection, one case of intraarticular screw penetration and one case of failure of fi xation were noted. No cases of avascular necrosis, hardware failure, locking screw loosening or nonunion were noted. Conclusion: PHILOS provides stable fixation in proximal humerus fractures. To prevent potential complications like avascular necrosis, meticulous surgical dissection to preserve vascularity of humeral head is necessary. Key words: Proximal humerus fracture; Fracture fixation, internal; Proximal humeral internal locking system

  17. Novel Biosensor of Membrane Protein Proximity Based on Fluorogen Activated Proteins.

    Science.gov (United States)

    Vasilev, Kalin V; Gallo, Eugenio; Shank, Nathaniel; Jarvik, Jonathan W

    2016-01-01

    We describe a novel biosensor system for reporting proximity between cell surface proteins in live cultured cells. The biosensor takes advantage of recently developed fluorogen-activating proteins (FAPs) that display fluorescence only when bound to otherwise-nonfluorescent fluorogen molecules. To demonstrate feasibility for the approach, two recombinant rapamycin-binding proteins were expressed as single-pass plasma membrane proteins in HeLa cells; one of the proteins (scAvd- FRB) carried an extracellular avidin tag; the other (HL1-TO1-FKBP) carried an extracellular FAP. Cells were incubated with a membrane-impermeable bivalent ligand (biotin-PEG2000-DIR) consisting of biotin joined to a dimethyl-indole red (DIR) fluorogen by a polyethylene glycol linker, thus tethering the fluorogen to the scAvd-FRB fusion protein. Addition of rapamycin, which promotes FKBP-FRB dimerization and thereby brings the FAP in close proximity to the tethered fluorogen, led to a significant increase in DIR fluorescence. We call the new proximity assay TEFLA, for tethered fluorogen assay.

  18. Flux analysis of the human proximal colon using anaerobic digestion model 1.

    Science.gov (United States)

    Motelica-Wagenaar, Anne Marieke; Nauta, Arjen; van den Heuvel, Ellen G H M; Kleerebezem, Robbert

    2014-08-01

    The colon can be regarded as an anaerobic digestive compartment within the gastro intestinal tract (GIT). An in silico model simulating the fluxes in the human proximal colon was developed on basis of the anaerobic digestion model 1 (ADM1), which is traditionally used to model waste conversion to biogas. Model calibration was conducted using data from in vitro fermentation of the proximal colon (TIM-2), and, amongst others, supplemented with the bio kinetics of prebiotic galactooligosaccharides (GOS) fermentation. The impact of water and solutes absorption by the host was also included. Hydrolysis constants of carbohydrates and proteins were estimated based on total short chain fatty acids (SCFA) and ammonia production in vitro. Model validation was established using an independent dataset of a different in vitro model: an in vitro three-stage continuous culture system. The in silico model was shown to provide quantitative insight in the microbial community structure in terms of functional groups, and the substrate and product fluxes between these groups as well as the host, as a function of the substrate composition, pH and the solids residence time (SRT). The model confirms the experimental observation that methanogens are washed out at low pH or low SRT-values. The in silico model is proposed as useful tool in the design of experimental setups for in vitro experiments by giving insight in fermentation processes in the proximal human colon. Copyright © 2014. Published by Elsevier Ltd.

  19. Many-body localization proximity effects in platforms of coupled spins and bosons

    Science.gov (United States)

    Marino, J.; Nandkishore, R. M.

    2018-02-01

    We discuss the onset of many-body localization in a one-dimensional system composed of a XXZ quantum spin chain and a Bose-Hubbard model linearly coupled together. We consider two complementary setups, depending whether spatial disorder is initially imprinted on spins or on bosons; in both cases, we explore the conditions for the disordered portion of the system to localize by proximity of the other clean half. Assuming that the dynamics of one of the two parts develops on shorter time scales than the other, we can adiabatically eliminate the fast degrees of freedom, and derive an effective Hamiltonian for the system's remainder using projection operator techniques. Performing a locator expansion on the strength of the many-body interaction term or on the hopping amplitude of the effective Hamiltonian thus derived, we present results on the stability of the many-body localized phases induced by proximity effect. We also briefly comment on the feasibility of the proposed model through modern quantum optics architectures, with the long-term perspective to realize experimentally, in composite open systems, Anderson or many-body localization proximity effects.

  20. Exploration of Hand Grasp Patterns Elicitable Through Non-Invasive Proximal Nerve Stimulation.

    Science.gov (United States)

    Shin, Henry; Watkins, Zach; Hu, Xiaogang

    2017-11-29

    Various neurological conditions, such as stroke or spinal cord injury, result in an impaired control of the hand. One method of restoring this impairment is through functional electrical stimulation (FES). However, traditional FES techniques often lead to quick fatigue and unnatural ballistic movements. In this study, we sought to explore the capabilities of a non-invasive proximal nerve stimulation technique in eliciting various hand grasp patterns. The ulnar and median nerves proximal to the elbow joint were activated transcutanously using a programmable stimulator, and the resultant finger flexion joint angles were recorded using a motion capture system. The individual finger motions averaged across the three joints were analyzed using a cluster analysis, in order to classify the different hand grasp patterns. With low current intensity (grasp patterns including single finger movement and coordinated multi-finger movements. This study provides initial evidence on the feasibility of a proximal nerve stimulation technique in controlling a variety of finger movements and grasp patterns. Our approach could also be developed into a rehabilitative/assistive tool that can result in flexible movements of the fingers.

  1. Residential proximity to abandoned uranium mines and serum inflammatory potential in chronically exposed Navajo communities.

    Science.gov (United States)

    Harmon, Molly E; Lewis, Johnnye; Miller, Curtis; Hoover, Joseph; Ali, Abdul-Mehdi S; Shuey, Chris; Cajero, Miranda; Lucas, Selita; Zychowski, Katherine; Pacheco, Bernadette; Erdei, Esther; Ramone, Sandy; Nez, Teddy; Gonzales, Melissa; Campen, Matthew J

    2017-07-01

    Members of the Navajo Nation, who possess a high prevalence of cardiometabolic disease, reside near hundreds of local abandoned uranium mines (AUM), which contribute uranium, arsenic and other metals to the soil, water and air. We recently reported that hypertension is associated with mine waste exposures in this population. Inflammation is a major player in the development of numerous vascular ailments. Our previous work establishing that specific transcriptional responses of cultured endothelial cells treated with human serum can reveal relative circulating inflammatory potential in a manner responsive to pollutant exposures, providing a model to assess responses associated with exposure to these waste materials in this population. To investigate a potential link between exposures to AUM and serum inflammatory potential in affected communities, primary human coronary artery endothelial cells were treated for 4 h with serum provided by Navajo study participants (n=145). Endothelial transcriptional responses of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and chemokine ligand 2 (CCL2) were measured. These transcriptional responses were then linked to AUM exposure metrics, including surface area-weighted AUM proximity and estimated oral intake of metals. AUM proximity strongly predicted endothelial transcriptional responses to serum including CCL2, VCAM-1 and ICAM-1 (Puranium did not, even after controlling for all major effect modifiers. Inflammatory potential associated with proximity to AUMs, but not oral intake of specific metals, additionally suggests a role for inhalation exposure as a contributor to cardiovascular disease.

  2. Local pH domains regulate NHE3-mediated Na+ reabsorption in the renal proximal tubule

    Science.gov (United States)

    Burford, James L.; McDonough, Alicia A.; Holstein-Rathlou, Niels-Henrik; Peti-Peterdi, Janos

    2014-01-01

    The proximal tubule Na+/H+ exchanger 3 (NHE3), located in the apical dense microvilli (brush border), plays a major role in the reabsorption of NaCl and water in the renal proximal tubule. In response to a rise in blood pressure NHE3 redistributes in the plane of the plasma membrane to the base of the brush border, where NHE3 activity is reduced. This NHE3 redistribution is assumed to provoke pressure natriuresis; however, it is unclear how NHE3 redistribution per se reduces NHE3 activity. To investigate if the distribution of NHE3 in the brush border can change the reabsorption rate, we constructed a spatiotemporal mathematical model of NHE3-mediated Na+ reabsorption across a proximal tubule cell and compared the model results with in vivo experiments in rats. The model predicts that when NHE3 is localized exclusively at the base of the brush border, it creates local pH microdomains that reduce NHE3 activity by >30%. We tested the model's prediction experimentally: the rat kidney cortex was loaded with the pH-sensitive fluorescent dye BCECF, and cells of the proximal tubule were imaged in vivo using confocal fluorescence microscopy before and after an increase of blood pressure by ∼50 mmHg. The experimental results supported the model by demonstrating that a rise of blood pressure induces the development of pH microdomains near the bottom of the brush border. These local changes in pH reduce NHE3 activity, which may explain the pressure natriuresis response to NHE3 redistribution. PMID:25298526

  3. The role of proximal body information on anticipatory judgment in tennis using graphical information richness.

    Directory of Open Access Journals (Sweden)

    Kazunobu Fukuhara

    Full Text Available Recent studies have reported that skilled tennis players are likely to use proximal body information for anticipating the direction of their opponent's forehand shot. However, in these studies, the visual stimuli did not include visual information about the ball. Skilled players may have used proximal information owing to the lack of distal information. To address this issue, we developed a novel methodological approach using computer graphics (CG images in which the entire body was presented by a combination of point-light display (i.e., poor graphical information, PLD and polygons (i.e., rich graphical information. Using our novel methodological approach, we examined whether skilled tennis players use proximal body information when anticipating shot directions.Fifteen skilled tennis players and fifteen novice players tried to anticipate shot directions by observing four CG forehand strokes (ALPOL: all body parts were represented with polygon; RAPLD: racket and arm were represented with PLD; BOPLD: body parts without racket and arm were represented with PLD; and ALPLD: all body parts were represented with PLD. Our intention in creating CG models with such combinations (i.e., RAPLD and BOPLD was that because of the richer graphical information provided by polygons compared to PLD, the participant's anticipatory judgment would be influenced more by body parts expressed with polygons. The results showed that for skilled players, anticipatory judgment was more accurate when they observed RAPLD than when they observed BOPLD and ALPLD. In contrast, for novice players, there were no differences in the accuracy of anticipatory judgments with the four CG models.Only skilled players made more accurate anticipatory judgments when body regions were expressed with rich graphical information, and the racket and arm were expressed with poor graphical information. These suggest that skilled players used proximal information to effectively anticipate shot

  4. A new scintillation proximity assay-based approach for the detection of KRAS mutations

    Energy Technology Data Exchange (ETDEWEB)

    Lee, So-Young; Lim, Jae-Cheong; Cho, Eun-Ha; Jung, Sung-Hee [Korea Atomic Energy Research Institute (KAERI), Daejeon (Korea, Republic of). Radioisotope Research Div.

    2016-04-01

    KRAS is very commonly mutated resulting in a constitutively activated protein, which is independent of epidermal growth factor receptor (EGFR) ligand binding and resistant to anti-EGFR therapy. Although KRAS is frequently studied, there is still no uniform standard for detecting of KRAS mutations. In this report, a new scintillation proximity assay-based approach is described that determines the relative affinities of wild-type and mutated KRAS to the anti-KRAS antibody. We performed in vitro experiments using normal human colonic cells (CCD18Co), KRAS wild type (Caco-2) and KRAS mutant (HCT 116) cell lines to determine the relative affinities of wild type or mutated KRAS toward an anti-KRAS monoclonal antibody. The process consists of two primary steps: immunoprecipitation from cell lysate to enrich the KRAS protein and the scintillation proximity assay of the immunoprecipitant to determine the relative affinity against the antibody. A fixed concentration of cell lysates was purified by the immunoprecipitation method. The expressions of the KRAS protein in all cell lines was quantitatively confirmed by western blot analysis. For the scintillation proximity assay, the KRAS standard protein was radiolabeled with {sup 125}I by a simple mixing process in the iodogen tube immediately at room temperature immediately before use. The obtained CPM (count per minute) values of were used to calculate the KRAS concentration using purified KRAS as the standard. The calculated relative affinities of 7 μg of Caco-2 and HCT 116 immunoprecipitants for the anti-KRAS antibody were 77 and 0%, respectively. The newly developed scintillation proximity assay-based strategy determines the relative affinities of wild-type or mutated KRAS towards the anti-KRAS monoclonal antibody. This determination can help distinguish mutated KRAS from the wild type protein. The new SPA based approach for detecting KRAS mutations is applicable to many other cancer-related mutations.

  5. A new scintillation proximity assay-based approach for the detection of KRAS mutations

    International Nuclear Information System (INIS)

    Lee, So-Young; Lim, Jae-Cheong; Cho, Eun-Ha; Jung, Sung-Hee

    2016-01-01

    KRAS is very commonly mutated resulting in a constitutively activated protein, which is independent of epidermal growth factor receptor (EGFR) ligand binding and resistant to anti-EGFR therapy. Although KRAS is frequently studied, there is still no uniform standard for detecting of KRAS mutations. In this report, a new scintillation proximity assay-based approach is described that determines the relative affinities of wild-type and mutated KRAS to the anti-KRAS antibody. We performed in vitro experiments using normal human colonic cells (CCD18Co), KRAS wild type (Caco-2) and KRAS mutant (HCT 116) cell lines to determine the relative affinities of wild type or mutated KRAS toward an anti-KRAS monoclonal antibody. The process consists of two primary steps: immunoprecipitation from cell lysate to enrich the KRAS protein and the scintillation proximity assay of the immunoprecipitant to determine the relative affinity against the antibody. A fixed concentration of cell lysates was purified by the immunoprecipitation method. The expressions of the KRAS protein in all cell lines was quantitatively confirmed by western blot analysis. For the scintillation proximity assay, the KRAS standard protein was radiolabeled with 125 I by a simple mixing process in the iodogen tube immediately at room temperature immediately before use. The obtained CPM (count per minute) values of were used to calculate the KRAS concentration using purified KRAS as the standard. The calculated relative affinities of 7 μg of Caco-2 and HCT 116 immunoprecipitants for the anti-KRAS antibody were 77 and 0%, respectively. The newly developed scintillation proximity assay-based strategy determines the relative affinities of wild-type or mutated KRAS towards the anti-KRAS monoclonal antibody. This determination can help distinguish mutated KRAS from the wild type protein. The new SPA based approach for detecting KRAS mutations is applicable to many other cancer-related mutations.

  6. Short-term results of catheter-directed intrathrombus thrombolysis versus anticoagulation in acute proximal deep vein thrombosis

    Directory of Open Access Journals (Sweden)

    Chiu-Yang Lee

    2013-05-01

    Conclusion: Duplex ultrasound analysis of thrombus progression is useful for assessing the treatment of a patient with acute proximal DVT. In this study, patients undergoing CDT experienced higher thrombus resolution and early recanalization of their veins, which may preserve venous function and further prevent development of post-thrombotic syndrome.

  7. Proximity to agricultural fields as proxy for environmental exposure to pesticides among children : The PIAMA birth cohort

    NARCIS (Netherlands)

    Bukalasa, Joseph S; Brunekreef, Bert; Brouwer, Maartje; Vermeulen, Roel; de Jongste, Johan C.; van Rossem, Lenie; Vonk, Judith M.; Wijga, Alet; Huss, Anke; Gehring, Ulrike

    2017-01-01

    Background: Agricultural pesticides are frequently used for crop protection. Residents living in close proximity to treated fields may be exposed to these pesticides. There is some indication that children living near agricultural fields have an increased risk of developing asthma and decreased lung

  8. Super-Relaxed ( -Proximal Point Algorithms, Relaxed ( -Proximal Point Algorithms, Linear Convergence Analysis, and Nonlinear Variational Inclusions

    Directory of Open Access Journals (Sweden)

    Agarwal RaviP

    2009-01-01

    Full Text Available We glance at recent advances to the general theory of maximal (set-valued monotone mappings and their role demonstrated to examine the convex programming and closely related field of nonlinear variational inequalities. We focus mostly on applications of the super-relaxed ( -proximal point algorithm to the context of solving a class of nonlinear variational inclusion problems, based on the notion of maximal ( -monotonicity. Investigations highlighted in this communication are greatly influenced by the celebrated work of Rockafellar (1976, while others have played a significant part as well in generalizing the proximal point algorithm considered by Rockafellar (1976 to the case of the relaxed proximal point algorithm by Eckstein and Bertsekas (1992. Even for the linear convergence analysis for the overrelaxed (or super-relaxed ( -proximal point algorithm, the fundamental model for Rockafellar's case does the job. Furthermore, we attempt to explore possibilities of generalizing the Yosida regularization/approximation in light of maximal ( -monotonicity, and then applying to first-order evolution equations/inclusions.

  9. Proximity effect bilayer nano superconducting quantum interference devices for millikelvin magnetometry

    Energy Technology Data Exchange (ETDEWEB)

    Blois, A., E-mail: a.blois@ucl.ac.uk; Rozhko, S.; Romans, E. J. [London Centre for Nanotechnology, University College London (UCL), 17-19 Gordon Street, London WC1H 0AH (United Kingdom); Hao, L.; Gallop, J. C. [National Physical Laboratory, Hampton Road, Teddington, Middlesex TW11 0LW (United Kingdom)

    2013-12-21

    Superconducting quantum interference devices (SQUIDs) incorporating thin film nanobridges as weak links have sensitivities approaching that required for single spin detection at 4.2 K. However, due to thermal hysteresis they are difficult to operate at much lower temperatures which hinder their application to many quantum measurements. To overcome this, we have developed nanoscale SQUIDs made from titanium-gold proximity bilayers. We show that their electrical properties are consistent with a theoretical model developed for heat flow in bilayers and demonstrate that they enable magnetic measurements to be made on a sample at system temperatures down to 60 mK.

  10. Isolation and characterization of a primary proximal tubular epithelial cell model from human kidney by CD10/CD13 double labeling.

    Directory of Open Access Journals (Sweden)

    Cynthia Van der Hauwaert

    Full Text Available Renal proximal tubular epithelial cells play a central role in renal physiology and are among the cell types most sensitive to ischemia and xenobiotic nephrotoxicity. In order to investigate the molecular and cellular mechanisms underlying the pathophysiology of kidney injuries, a stable and well-characterized primary culture model of proximal tubular cells is required. An existing model of proximal tubular cells is hampered by the cellular heterogeneity of kidney; a method based on cell sorting for specific markers must therefore be developed. In this study, we present a primary culture model based on the mechanical and enzymatic dissociation of healthy tissue obtained from nephrectomy specimens. Renal epithelial cells were sorted using co-labeling for CD10 and CD13, two renal proximal tubular epithelial markers, by flow cytometry. Their purity, phenotypic stability and functional properties were evaluated over several passages. Our results demonstrate that CD10/CD13 double-positive cells constitute a pure, functional and stable proximal tubular epithelial cell population that displays proximal tubule markers and epithelial characteristics over the long term, whereas cells positive for either CD10 or CD13 alone appear to be heterogeneous. In conclusion, this study describes a method for establishing a robust renal proximal tubular epithelial cell model suitable for further experimentation.

  11. The Mediating Roles of Rejection Sensitivity and Proximal Stress in the Association Between Discrimination and Internalizing Symptoms Among Sexual Minority Women.

    Science.gov (United States)

    Dyar, Christina; Feinstein, Brian A; Eaton, Nicholas R; London, Bonita

    2018-01-01

    The negative impact of discrimination on mental health among lesbian, gay, and bisexual populations has been well documented. However, the possible mediating roles of sexual orientation rejection sensitivity and rejection-based proximal stress in the association between discrimination and internalizing symptoms remain unclear. Rejection-based proximal stress is a subset of proximal stressors that are theorized to arise from concerns about and expectations of sexual orientation-based rejection and discrimination. Drawing on minority stress theory, we tested potential mediating effects using indirect effects structural equation modeling in a sample of 300 sexual minority women. Results indicated that the indirect effect of discrimination on internalizing symptoms (a latent variable indicated by depression and anxiety symptoms) through sexual orientation rejection sensitivity and rejection-based proximal stress (a latent variable indicated by preoccupation with stigma, concealment motivation, and difficulty developing a positive sexual identity) was significant. Additionally, the indirect effects of discrimination on rejection-based proximal stress through sexual orientation rejection sensitivity and of sexual orientation rejection sensitivity on internalizing symptoms through rejection-based proximal stress were also significant. These findings indicate that sexual orientation rejection sensitivity plays an important role in contributing to rejection-based proximal stress and internalizing symptoms among sexual minority women.

  12. Radiographic and Computed Tomographic Configuration of Incomplete Proximal Fractures of the Proximal Phalanx in Horses Not Used for Racing.

    Science.gov (United States)

    Brünisholz, Hervé P; Hagen, Regine; Fürst, Anton E; Kuemmerle, Jan M

    2015-10-01

    To characterize the configuration of incomplete proximal fractures of the proximal phalanx (P1) in horses not used for racing and compare radiographic with computed tomography (CT) findings. Historical cohort. Twenty-four horses with incomplete fractures of P1. Medical records of horses not used for racing diagnosed with an incomplete proximal fracture of P1 based on clinical and radiographic examination and confirmed by CT between 2008 and 2013 were retrieved. Radiographs and CT studies of these horses were analyzed using a subjective grading system and by measuring variables that characterized fracture configuration. Twenty-four horses were included (20 Warmbloods) with a mean age of 9.5 years and mean body weight of 574 kg. Fourteen forelimbs and 10 hind limbs were affected. Mean duration of lameness was 8.7 weeks. Computed tomography was superior to radiography in both identifying the fracture and determining fracture size and location. On CT, 92% of fractures were located in the mid-sagittal plane. Mean proximodistal length of the fracture was 13 mm. Fractures were frequently not bicortical. Fractures in forelimbs were located significantly more dorsally than fractures in hind limbs. A distinct fracture pattern with 2 subchondral lines running parallel in close proximity to each other was identified in 54% of cases. Incomplete proximal fractures of P1 have significant variation in their configurations, especially their dorsopalmar/-plantar location. Computed tomography examination allowed clear identification of the fracture configurations and was superior to radiography. © Copyright 2015 by The American College of Veterinary Surgeons.

  13. Objective quantification of the food proximity effect on grapes, chocolate and cracker consumption in a Swedish high school. A temporal analysis.

    Science.gov (United States)

    Langlet, Billy; Fagerberg, Petter; Glossner, Andrew; Ioakimidis, Ioannis

    2017-01-01

    Close food proximity leads to increased short-term energy intake, potentially contributing to the long-term development of obesity. However, its precise effects on eating behaviour are still unclear, especially with food available for extended periods of time. This study involved two similar high school student groups (15-17 years old), which had ad libitum access to grapes, chocolates and crackers during an hour-long experimental session. In the distal condition the foods were placed 6 meters away from the students (n = 24), in contrast to the proximal condition (n = 17) were the food was placed near the students. The identification of the type and the quantification of the amount of each food selected, for each individual serving, was facilitated through use of food scales and video recording. In the proximal condition individuals served themselves grapes and crackers more often and consumed more chocolate than in the distal condition. In total, participants in the proximal condition ingested significantly more energy (726 kcal vs. 504 kcal; p = 0.029), without reporting higher fullness. Food proximity also affected the temporal distribution of servings, with the first five minutes of the sessions corresponding to 53.1% and 45.6% of the total energy intake for the distal and proximal conditions, respectively. After the first five minutes, the servings in the distal condition were strongly clustered in time, with many students getting food together. In the proximal condition however, students displayed an unstructured pattern of servings over time. In conclusion, this study strengthens past evidence regarding the important role of food proximity on individual energy intake and, for the first time, it associates continuous food proximity to the emergence of unstructured eating over time. These conclusions, expanded upon by future studies, could support the creation of meaningful intervention strategies based on spatially and temporally controlled food availability.

  14. Squamous cell dysplasia in the proximal rectum of three patients treated for ulcerative colitis on immunomodulators.

    Science.gov (United States)

    Connolly, James G; Goldstone, Stephen E

    2017-05-01

    Anal canal high-grade squamous intraepithelial lesion (HSIL) is the precursor to anal cancer. Immunocompromised patients are at increased risk and disease is usually within 3 cm from the anal verge. High-resolution anoscopy (HRA) with an 8-cm anoscope is used to identify and guide cautery treatment of HSIL. We report three patients with a long-term history of ulcerative colitis (UC) treated with systemic immunomodulators who developed proximally located rectal HSIL. Two patients were HIV-negative women, 63 and 48 years old, and the third was a 51-year-old HIV-positive man with underlying UC for 10, 16, and 3 years, respectively. They each presented with a HPV-positive HSIL visibly extending above the limits of the anoscope used for HRA. None developed cancer. All had episodes of active UC. It is unclear what causative role systemic immunomodulators play in predisposing UC patients to proximal HSIL. HSIL probably developed on a tongue of HPV-infected squamous epithelium growing proximally over the inflamed rectum. Islands developed when areas of squamous epithelium degenerated, creating skip areas. This study highlights the potential for HSIL to extend into the rectum either as a contiguous patch or isolated islands and the need for heightened surveillance in patients with extensive anal canal HSIL treated with immunodulator therapy. HSIL identified at the limit of the anoscope should be investigated further with colonoscopy, and argon plasma coagulation (APC) ablation can serve as an effective treatment option. Patients are at risk for stricture, but it is unclear what role the UC or the ablation played in stricture formation.

  15. Effect of paddock vs. stall housing on 24 hour gastric pH within the proximal and ventral equine stomach.

    Science.gov (United States)

    Husted, L; Sanchez, L C; Olsen, S N; Baptiste, K E; Merritt, A M

    2008-06-01

    Stall housing has been suggested as a risk factor for ulcer development in the equine stomach; however, the exact pathogenesis for this has not been established. To investigate the effect of 3 environmental situations (grass paddock, stall alone or stall with adjacent companion) on pH in the proximal and the ventral stomach. Six horses with permanently implanted gastric cannulae were used in a randomised, cross-over, block design. Each horse rotated through each of three 24 h environmental situations. Horses remained on their normal diet (grass hay ad libitum and grain b.i.d.) throughout the study. Intragastric pH was measured continuously for 72 h just inside the lower oesophageal sphincter (proximal stomach) and via a pH probe in the gastric cannula (ventral stomach). Neither proximal nor ventral 24 h gastric pH changed significantly between the 3 environmental situations. Mean hourly proximal gastric pH decreased significantly in the interval from 01.00-09.00 h compared to the interval from 13.00-20.00 h, regardless of environmental situation. Median hourly proximal pH only differed in the interval from 06.00-07.00 h compared to the interval 14.00-19.00 h. Neither mean nor median hourly ventral gastric pH varied significantly with the time of day. The change in housing status used in the current study did not affect acid exposure within either region of the equine stomach. The pH in the ventral stomach was uniformly stable throughout the study, while the proximal pH demonstrated a 24 h circadian pattern.

  16. Hazard proximity and risk perception of tsunamis in coastal cities: Are people able to identify their risk?

    Science.gov (United States)

    Arias, Juan Pablo; Bronfman, Nicolás C; Cisternas, Pamela C; Repetto, Paula B

    2017-01-01

    Researchers have previously reported that hazard proximity can influence risk perception among individuals exposed to potential hazards. Understanding this relationship among coastline communities at risk of flood events caused by storms and/or tsunamis, is important because hazard proximity, should be recognized when planning and implementing preparation and mitigation actions against these events. Yet, we are not aware of studies that have examined this relationship among coastline inhabitants facing the risk of a tsunami. Consequently, the aim of this study was to examine the relationship between hazard proximity and perceived risk from tsunamis among coastline inhabitants. Participants were 487 residents of the coastal city of Iquique, Chile. They completed a survey during the spring of 2013 that assessed their perceived risk from several natural and non-natural hazards. We found that hazard proximity maintains a negative relationship with the perception of tsunami risk among coastline inhabitants. While this result confirms the general trend obtained in previous studies, this one is conclusive and significant. In contradiction with previous findings, we found that participants from the highest socioeconomic status reported the highest levels of risk perception. This finding can be explained by the fact that most participants from the highest socioeconomic status live closer to the coastline areas, so their risk perception reflects the place where they live, that is in a tsunami inundation zone. Once again, hazard proximity proved to be a determinant factor of risk perception. Our findings have important implications for the development of plans and programs for tsunami preparedness and mitigation. These indicate that individuals do use environmental cues to evaluate their own risk and can potentially make correct choices when having or not to evacuate. Also suggest that preparedness should incorporate how hazard proximity is recognized by individuals and

  17. Hazard proximity and risk perception of tsunamis in coastal cities: Are people able to identify their risk?

    Science.gov (United States)

    Arias, Juan Pablo; Bronfman, Nicolás C.; Cisternas, Pamela C.; Repetto, Paula B.

    2017-01-01

    Researchers have previously reported that hazard proximity can influence risk perception among individuals exposed to potential hazards. Understanding this relationship among coastline communities at risk of flood events caused by storms and/or tsunamis, is important because hazard proximity, should be recognized when planning and implementing preparation and mitigation actions against these events. Yet, we are not aware of studies that have examined this relationship among coastline inhabitants facing the risk of a tsunami. Consequently, the aim of this study was to examine the relationship between hazard proximity and perceived risk from tsunamis among coastline inhabitants. Participants were 487 residents of the coastal city of Iquique, Chile. They completed a survey during the spring of 2013 that assessed their perceived risk from several natural and non-natural hazards. We found that hazard proximity maintains a negative relationship with the perception of tsunami risk among coastline inhabitants. While this result confirms the general trend obtained in previous studies, this one is conclusive and significant. In contradiction with previous findings, we found that participants from the highest socioeconomic status reported the highest levels of risk perception. This finding can be explained by the fact that most participants from the highest socioeconomic status live closer to the coastline areas, so their risk perception reflects the place where they live, that is in a tsunami inundation zone. Once again, hazard proximity proved to be a determinant factor of risk perception. Our findings have important implications for the development of plans and programs for tsunami preparedness and mitigation. These indicate that individuals do use environmental cues to evaluate their own risk and can potentially make correct choices when having or not to evacuate. Also suggest that preparedness should incorporate how hazard proximity is recognized by individuals and

  18. The connection of socio-demographic factors and child-parent relationships to the psychological aspects of children’s development

    Directory of Open Access Journals (Sweden)

    Sobkin V. S.

    2016-12-01

    Full Text Available Preschool childhood is a time of rapid development. During this period a child`s interaction with significant adults plays a very important role. The parent, as a mediator, defines the “zone of proximal development” (Vygotsky, 1984. The common assumption is that to determine a parent’s position, it is important to acknowledge both socio-demographic factors and the parameters which define the socio-psychological aspects of parent-child relationship. Hence, the type of research where a child’s psychological development is studied in the context of the socio-demographic and socio-psychological factors which determine the social situation of development, is very promising. Based on our previous research (Sobkin, Marich, 2002; Cheie, Veraksa, 2015, a program of experimental research intended to determine the interconnections between the socio-demographic and socio-psychological parameters of parent-child relationships, and the level of a child’s psychic development, was designed. The research was based upon the material obtained through testing 59 children between 5 and 7 years old with specially collected psychological testing methods (Veraksa A.N. etc, as well as from the results of a special sociological questionnaire presented to their mothers (Sobkin V.S. etc. The research was carried out in 2014-2015 in municipal kindergartens of Moscow. Among the socio-demographic factors analyzed, the most significant results were related to the child’s gender, the family structure, and the mother’s education. Thus, boys showed higher results on visual memory tests, and girls scored better on tests for self-control and social intelligence (higher ability to detect the reason for someone else’s negative emotions. Children from single-parent families had better results on verbal memory tests, but scored lower on those for self-control. Also they had less ability for decentration. The differences in mothers’ educational levels influenced the

  19. Surgical management of proximal splint bone fractures in the horse

    International Nuclear Information System (INIS)

    Peterson, P.R.; Pascoe, J.R.; Wheat, J.D.

    1987-01-01

    Fractures of Metacarpal and Metatarsal II and IV (the splint bones) were treated in 283 horses over an 11 year period. In 21 cases the proximal portion of the fractured bone was stabilized with metallic implants. One or more cortical bone screws were used in 11 horses, and bone plates were applied in 11 horses. One horse received both treatments. Complications of screw fixation included bone failure, implant failure, radiographic lucency around the screws, and proliferative new bone at the ostectomy site. Only two of the horses treated with screw fixation returned to their intended use. Complications of plate fixation included partial fixation failure (backing out of screws), wound drainage, and proliferative bony response around the plate. Six of the 11 horses treated by plate fixation returned to their intended use. The authors recommend consideration of plate fixation techniques for repair of fractures in the proximal third of the splint bone

  20. Adaptive Proximal Point Algorithms for Total Variation Image Restoration

    Directory of Open Access Journals (Sweden)

    Ying Chen

    2015-02-01

    Full Text Available Image restoration is a fundamental problem in various areas of imaging sciences. This paper presents a class of adaptive proximal point algorithms (APPA with contraction strategy for total variational image restoration. In each iteration, the proposed methods choose an adaptive proximal parameter matrix which is not necessary symmetric. In fact, there is an inner extrapolation in the prediction step, which is followed by a correction step for contraction. And the inner extrapolation is implemented by an adaptive scheme. By using the framework of contraction method, global convergence result and a convergence rate of O(1/N could be established for the proposed methods. Numerical results are reported to illustrate the efficiency of the APPA methods for solving total variation image restoration problems. Comparisons with the state-of-the-art algorithms demonstrate that the proposed methods are comparable and promising.

  1. Efficient Indoor Proximity and Separation Detection for Location Fingerprinting

    DEFF Research Database (Denmark)

    Kjærgaard, Mikkel Baun; Treu, Georg; Ruppel, Peter

    2008-01-01

    the respective building topology. The approach applies efficient strategies to reduce the number of messages transmitted between the mobile targets and a central location server, thus saving the targets' battery power, bandwidth, and other resources. The strategies are evaluated in terms of efficiency......Detecting proximity and separation among mobile targets is a basic mechanism for many location-based services (LBSs) and requires continuous positioning and tracking. However, realizing both mechanisms for indoor usage is still a major challenge. Positioning methods like GPS cannot be applied there......, and for distance calculations the particular building topology has to be taken into account. To address these challenges, this paper presents a novel approach for indoor proximity and separation detection, which uses location fingerprinting for indoor positioning of targets and walking distances for modeling...

  2. Interventions for treating proximal humeral fractures in adults

    DEFF Research Database (Denmark)

    Handoll, Helen H G; Brorson, Stig

    2015-01-01

    supervised exercise in a swimming pool plus home exercise.Eight trials, involving 567 older participants, evaluated surgical intervention for displaced fractures. There was high quality evidence of no clinically important difference in patient-reported shoulder and upper-limb function at one- or two......BACKGROUND: Fracture of the proximal humerus, often termed shoulder fracture, is a common injury in older people. The management of these fractures varies widely. This is an update of a Cochrane Review first published in 2001 and last updated in 2012. OBJECTIVES: To assess the effects (benefits...... and harms) of treatment and rehabilitation interventions for proximal humeral fractures in adults. SEARCH METHODS: We searched the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, and other databases, conference...

  3. Synostosis of proximal phalangeal bases for loss of distal metacarpal

    Directory of Open Access Journals (Sweden)

    Pankaj Jindal

    2016-01-01

    Full Text Available A finger rendered unstable due to loss of metacarpal head can be stabilized by creating a synostosis at the base of the proximal phalanx of the affected finger with the adjacent normal finger. A cortico cancellous graft bridges the two adjacent proximal phalanges at their bases which are temporarily stabilized with an external fixator. The procedure can be done for, recurrence of giant cell tumor of metacarpal and for traumatic metacarpal loss. The procedure and long term follow up of one patient is presented who had giant cell tumor. This option should be considered before offering ray amputation. There is no micro vascular surgery involved, nor is there any donor site morbidity. The graft heals well without any absorption. The affected finger shows excellent function in the long term followup.

  4. Affordable dual-sensing proximity sensor for touchless interactive systems

    KAUST Repository

    Nassar, Joanna M.

    2016-09-13

    We report an ultra-low cost flexible proximity sensor using only off-the-shelf recyclable materials such as aluminum foil, napkin and double-sided tape. Unlike previous reports, our device structure exhibits two sensing capabilities in one platform, with outstanding long detection range of 20 cm and pressure sensitivity of 0.05 kPa. This is the first ever demonstration of a low-cost, accessible, and batch manufacturing process for pressure and proximity sensing on a singular platform. The mechanical flexibility of the sensor makes it possible to mount on various irregular platforms, which is vital in many areas, such as robotics, machine automation, vehicular technology and inspection tools.

  5. Impact of Relational Proximity on Distress from Infidelity

    Directory of Open Access Journals (Sweden)

    Maryanne Fisher

    2009-10-01

    Full Text Available Men are generally more distressed by a partner's sexual infidelity whereas women are generally more distressed by a partner's emotional infidelity. The importance of the identity of the interloper, however, has been neglected. We explored the influence of relational proximity (i.e., the degree of genetic relatedness on distress about infidelity. In Study 1, participants were most distressed when the imagined infidelity occurred between their current mate and close kin. In Study 2, relational proximity mattered more than the type of sexual behavior, the likelihood of contracting a sexually transmitted disease, and the likelihood of the infidelity leading to a damaged reputation. Together, the results indicate that identity matters, especially if the interloper is someone with whom we have familial bonds.

  6. Mutual proximity graphs for improved reachability in music recommendation.

    Science.gov (United States)

    Flexer, Arthur; Stevens, Jeff

    2018-01-01

    This paper is concerned with the impact of hubness, a general problem of machine learning in high-dimensional spaces, on a real-world music recommendation system based on visualisation of a k-nearest neighbour (knn) graph. Due to a problem of measuring distances in high dimensions, hub objects are recommended over and over again while anti-hubs are nonexistent in recommendation lists, resulting in poor reachability of the music catalogue. We present mutual proximity graphs, which are an alternative to knn and mutual knn graphs, and are able to avoid hub vertices having abnormally high connectivity. We show that mutual proximity graphs yield much better graph connectivity resulting in improved reachability compared to knn graphs, mutual knn graphs and mutual knn graphs enhanced with minimum spanning trees, while simultaneously reducing the negative effects of hubness.

  7. Quality of life in old patients with proximal femoral fractures

    Directory of Open Access Journals (Sweden)

    T A Raskina

    2012-01-01

    Full Text Available Objective: to study quality of life in Kemerovo old patients with proximal femoral fractures. Patients and methods. Quality of life in osteoporotic fractures was analyzed in 219 patients (173 women and 46 men who had sustained the injury in January 2004 to December 2008. Results. In the patients with hip fractures, the lowest (41.94+31.16 scores values were recorded by the physical functioning scale reflecting the degree to which their health limited the performance of physical exercises (self-service, walking, going upstairs, weight carriage, etc.. The role functioning and life activity scales showed the highest values (50.96+19.04 and 51.44+26.51 scores, respectively. The mean value of the physical component scale was 46.42+28.26 scores. That of the psychological component scale was 49.56+19.55 scores. Conclusion. The patients with proximal femoral fractures were found to have lower scores on all SF-36 dimensions.

  8. Aneurysms of proximal pulmonary arteries: CT diagnosis and preoperative assessment

    International Nuclear Information System (INIS)

    Iula, G.; Ziviello, R.; Del Vecchio, W.

    1996-01-01

    We reviewed our experience with proximal pulmonary artery aneurysm (PPAA) to determine whether accurate preoperative evaluation (crucial to differential diagnosis and surgical planning) had been obtained on the basis of CT study alone. Three patients with PPAA were studied with contrast-enhanced CT. We evaluated the size and shape of PPAAs, their proximal and distal extent, eventual presence of intraluminal thrombi, dissection, perianeurysmal fibrosis, and rupture. The results were compared with surgical findings. In two patients the aneurysm involved the pulmonary trunk and both the right and left arteries origin. In one patient the aneurysm extended from the left artery origin to the hilum of the left lung. Contrast-enhanced CT alone allows detection of aneurysm in the pulmonary trunk, in right or left pulmonary arteries with precise preoperative evaluation of the extent, size, shape, and complications. The CT imaging was unable to establish the etiologic origin and presence of small intimal tears in PPAA. (orig.)

  9. Proximate composition analysis posterior to the cryopreservation of Chaetoceros calcitrans

    Directory of Open Access Journals (Sweden)

    Joan Salas-Leiva

    2015-12-01

    Full Text Available Objective. The effect of cryopreservation on the proximate composition of microalgae Chaetoceros calcitrans was evaluated. Materials and methods. C. calcitrans was cultured and cryopreserved using 5% (v/v dimethylsulfoxide as cryoprotectant. The freezing was controlled at a rate of 3°C/min, up to -60°C and then the microalgae were immersed in liquid nitrogen (-196°C. After storage in liquid nitrogen, microalgae were rapidly thawed out and subcultured. The percentage of proteins, lipids and carbohydrates was analyzed using absorption spectrophotometry and the organic matter was studied by gravimetric analysis. Results. There was no significant variation between the proximate composition of C. calcitrans cryopreserved and the controls (p>0.05. Conclusion. Our results show that, despite low cell recovery after the preservation of this organism at low temperatures, there is no apparent loss of nutritional characteristics caused by the storing process at low temperatures.

  10. Mortality Following Periprosthetic Proximal Femoral Fractures Versus Native Hip Fractures.

    Science.gov (United States)

    Boylan, Matthew R; Riesgo, Aldo M; Paulino, Carl B; Slover, James D; Zuckerman, Joseph D; Egol, Kenneth A

    2018-04-04

    The number of periprosthetic proximal femoral fractures is expected to increase with the increasing prevalence of hip arthroplasties. While native hip fractures have a well-known association with mortality, there are currently limited data on this outcome among the subset of patients with periprosthetic proximal femoral fractures. Using the New York Statewide Planning and Research Cooperative System, we identified patients from 60 to 99 years old who were admitted to a hospital in the state with a periprosthetic proximal femoral fracture (n = 1,655) or a native hip (femoral neck or intertrochanteric) fracture (n = 97,231) between 2006 and 2014. Within the periprosthetic fracture cohort, the indication for the existing implant was not available in the data set. We used mixed-effects regression models to compare mortality at 1 and 6 months and 1 year for periprosthetic compared with native hip fractures. The risk of mortality for patients who sustained a periprosthetic proximal femoral fracture was no different from that for patients who sustained a native hip fracture at 1 month after injury (3.2% versus 4.6%; odds ratio [OR], 0.90; 95% confidence interval [CI], 0.68 to 1.19; p = 0.446), but was lower at 6 months (3.8% versus 6.5%; OR, 0.74; 95% CI, 0.57 to 0.95; p = 0.020) and 1 year (9.7% versus 15.9%; OR, 0.71; 95% CI, 0.60 to 0.85; p accounting for age and comorbidities. Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.

  11. Social networks, geographic proximity, and firm performance in Viet Nam

    OpenAIRE

    Howard, Emma

    2017-01-01

    This paper uses panel data to assess the relative importance of social networks and geographic proximity to micro, small, and medium enterprises in Viet Nam. The results suggest that a larger social network, and hiring employees mainly through social networks, are both correlated with higher value added per worker. The number of government officials and civil servants in a firm's network emerges as particularly important. When the quality of contacts is controlled for, firms with tighter soci...

  12. Physical Proximity and Spreading in Dynamic Social Networks

    OpenAIRE

    Stopczynski, Arkadiusz; Pentland, Alex Sandy; Lehmann, Sune

    2015-01-01

    Most infectious diseases spread on a dynamic network of human interactions. Recent studies of social dynamics have provided evidence that spreading patterns may depend strongly on detailed micro-dynamics of the social system. We have recorded every single interaction within a large population, mapping out---for the first time at scale---the complete proximity network for a densely-connected system. Here we show the striking impact of interaction-distance on the network structure and dynamics ...

  13. Proximate Composition and Mineral Content in Different ,Types of

    African Journals Online (AJOL)

    The: concentration of protein in traditional and ... resuiis:in d;je~t types o[togwa wjth yariatiOl? in proximate comfX?sition, energy density and~mirieral content. " . ..... hi the preparation of simulated togwa l .,. "'.' .. IngredientS ,Dtj<: "\\C!~de P~o-.' Ct;ude fi-. Fat: --Ash. Caroo-. Energy matte; r tein (0/0) . ,; bee hydrate value .: (%).

  14. Advances in Proximal Interphalangeal Joint Arthroplasty: Biomechanics and Biomaterials.

    Science.gov (United States)

    Zhu, Andy F; Rahgozar, Paymon; Chung, Kevin C

    2018-05-01

    Proximal interphalangeal (PIP) joint arthritis is a debilitating condition. The complexity of the joint makes management particularly challenging. Treatment of PIP arthritis requires an understanding of the biomechanics of the joint. PIP joint arthroplasty is one treatment option that has evolved over time. Advances in biomaterials have improved and expanded arthroplasty design. This article reviews biomechanics and arthroplasty design of the PIP joint. Copyright © 2018 Elsevier Inc. All rights reserved.

  15. Pseudoarthrosis following proximal humeral fractures: A possible mechanism

    Energy Technology Data Exchange (ETDEWEB)

    Rooney, P.J.; Cockshott, W.P.

    1986-01-01

    A small series of four patients with pseudarthrosis of the proximal humeral shaft is reported. These patients all had restricted movement of the shoulder joint prior to the trauma, three as a result of rheumatoid arthritis and one due a surgical fusion of the glenohumeral joint. It is suggested that pseudarthrosis is more likely under these circumstances and that pursuit of union of the fracture in such patients may not always be necessary.

  16. Proximal Humerus Fractures: Evaluation and Management in the Elderly Patient

    Science.gov (United States)

    Grawe, Brian

    2018-01-01

    Introduction: Proximal humerus fractures are common in the elderly. The evaluation and management of these injuries is often controversial. The purpose of this study is to review recent evidence and provide updated recommendations for treating proximal humerus fractures in the elderly. Methods: A literature review of peer-reviewed publications related to the evaluation and management of proximal humerus fractures in the elderly was performed. There was a focus on randomized controlled trials and systematic reviews published within the last 5 years. Results: The incidence of proximal humerus fractures is increasing. It is a common osteoporotic fracture. Bone density is a predictor of reduction quality and can be readily assessed with anteroposterior views of the shoulder. Social independence is a predictor of outcome, whereas age is not. Many fractures are minimally displaced and respond acceptably to nonoperative management. Displaced and severe fractures are most frequently treated operatively with intramedullary nails, locking plates, percutaneous techniques, or arthroplasty. Discussion: Evidence from randomized controlled trials and systematic reviews is insufficient to recommend a treatment; however, most techniques have acceptable or good outcomes. Evaluation should include an assessment of the patient’s bone quality, social independence, and surgical risk factors. With internal fixation, special attention should be paid to medial comminution, varus angulation, and restoration of the calcar. With arthroplasty, attention should be paid to anatomic restoration of the tuberosities and proper placement of the prosthesis. Conclusion: A majority of minimally displaced fractures can be treated conservatively with early physical therapy. Treatment for displaced fractures should consider the patient’s level of independence, bone quality, and surgical risk factors. Fixation with percutaneous techniques, intramedullary nails, locking plates, and arthroplasty are all

  17. Stability and the proximity theorem in Casimir actuated nano devices

    Science.gov (United States)

    Esquivel-Sirvent, R.; Reyes, L.; Bárcenas, J.

    2006-10-01

    A brief description of the stability problem in micro and nano electromechanical devices (MEMS/NEMS) actuated by Casimir forces is given. To enhance the stability, we propose the use of curved surfaces and recalculate the stability conditions by means of the proximity force approximation. The use of curved surfaces changes the bifurcation point, and the radius of curvature becomes a control parameter, allowing a rescaling of the elastic restitution constant and/or of the typical dimensions of the device.

  18. How to tell the History. Proximity strategies on Argentine television

    Directory of Open Access Journals (Sweden)

    Elena Galán Fajardo

    2014-11-01

    Full Text Available This paper focuses on the analysis of a television documentary Algo habrán hecho (por la historia argentina, broadcast on Telefe and Canal 13, between 2005 and 2008. The interrelationship of discursive tools and informative and evocation strategies are very relevant in this text. Its effectiveness is related to a combined use of resources that appeal to different meanings of proximity, with the objective to make accessible the history to a popular audience.

  19. Theory of the superconducting proximity effect below the transition temperature

    International Nuclear Information System (INIS)

    Silvert, W.

    1975-01-01

    The form of the low-temperature theory of the superconducting proximity effect depends on whether the non-linear terms are assumed to depend only on the local value of the gap or on its average value over some finite range. The local assumption leads to smaller values of the gap and to unphysical results at low temperatures. The effect of non-locality is significant even in the Ginsburg-Landau regime. (author)

  20. Sensitivity Analysis of the Proximal-Based Parallel Decomposition Methods

    Directory of Open Access Journals (Sweden)

    Feng Ma

    2014-01-01

    Full Text Available The proximal-based parallel decomposition methods were recently proposed to solve structured convex optimization problems. These algorithms are eligible for parallel computation and can be used efficiently for solving large-scale separable problems. In this paper, compared with the previous theoretical results, we show that the range of the involved parameters can be enlarged while the convergence can be still established. Preliminary numerical tests on stable principal component pursuit problem testify to the advantages of the enlargement.