WorldWideScience

Sample records for provocative paradoxes emerged

  1. The nasal provocation test combined with spirometry establishes paradoxical vocal fold motion in allergic subjects.

    Science.gov (United States)

    Olivier, Celso Eduardo; Argentão, Daiana Guedes Pinto; Lima, Regiane Patussi dos Santos; da Silva, Mariana Dias; dos Santos, Raquel Acácia Pereira Gonçalves

    2013-01-01

    Vocal cord dysfunction (also called paradoxical vocal cord motion) or paradoxical vocal fold motion (PVFM) is an event elicited by specific and nonspecific triggers in which its diagnosis is limited by the restricted number of available functional tests. This study was designed to appreciate the contribution of the spirometric changes elicited by the allergen-specific nasal provocation test (NPT) performed with Dermatophagoides pteronyssinus for the diagnosis of PVFM in subjects with known sensitization to this allergen. In total, 63 subjects with allergic rhinitis who had previously been shown to be sensitized to D. pteronyssinus and who had experienced one or more episodes of inspiratory shortness of breath underwent two spirometric tests, one before (pre-NPT) and another 15 minutes after the allergen-specific NPT (post-NPT). The forced inspiratory vital capacity (FIVC), forced inspiratory volume in 2 seconds (FIV2), and the ratio between the FIV in 1 second and FIVC (FIV1/FIVC) were measured by spirometry. The morphology of the post-NPT inspiratory loop was compared with the pre-NPT inspiratory loop. We found that 18 subjects (28.5%) showed alterations suggestive of PVFM on post-NPT spirometry (e.g., truncation and/or flattening of the inspiratory loop). The mean differences between the pre-NPT and post-NPT values for the whole group were significant using a two-tailed paired t-test for the FIVC (4.1; 95% confidence interval [CI95%], 1.4-6.8), FIV1/FIVC ratio (2.7; CI95%, 0.05-5.3), and FIV2 (7.2; CI95%, 3.4-11). Allergen-specific NPT combined with spirometry is useful to show allergen-specific laryngeal hyperresponsiveness in allergic subjects with PVFM. Brazilian clinical trial registry platform (Plataforma Brasil, CAAE 07971212.0.0000.5480).

  2. De-labelling self-reported penicillin allergy within the emergency department through the use of skin tests and oral drug provocation testing.

    Science.gov (United States)

    Marwood, Joseph; Aguirrebarrena, Gonzalo; Kerr, Stephen; Welch, Susan A; Rimmer, Janet

    2017-10-01

    Self-reported penicillin allergy is common among patients attending the ED, but is a poor predictor of true immunoglobulin E-mediated hypersensitivity to penicillin. We hypothesise that with a combination of skin testing and drug provocation testing, selected patients can be safely de-labelled of their allergy. This prospective study enrolled a sample of patients presenting to an urban academic ED between 2011 and 2016 with a self-reported allergy to penicillin. Standardised skin prick and intradermal testing with amoxicillin and both major and minor determinants of penicillin was performed in the department. If negative, testing was followed by a graded oral challenge of amoxicillin over 9 days. The primary end point was the allergy status of participants at the end of the study. A total of 100 patients (mean age 42; standard deviation 14 years; 54% women) completed the testing. Of these, 81% (95% confidence interval 71.9-88.2) showed no hypersensitivity to penicillin and were labelled non-allergic. The majority (16/19) of allergies were confirmed by skin testing, with three suspected allergies detected by the oral challenge. Women were more likely than men to have a true penicillin allergy, with odds ratio of 4.0 (95% confidence interval 1.23-13.2). There were no serious adverse events. Selected patients in the ED who self-report an allergy to penicillin can be safely tested there for penicillin allergy, using skin tests and oral drug provocation testing. This testing allows a significant de-labelling of penicillin allergy, with the majority of these patients able to tolerate penicillin without incident. © 2017 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine.

  3. Provocative Video Scenarios

    DEFF Research Database (Denmark)

    Caglio, Agnese

    This paper presents the use of ”provocative videos”, as a tool to support and deepen findings from ethnographic investigation on the theme of remote videocommunication. The videos acted as a resource to also investigate potential for novel technologies supporting continuous connection between...

  4. [Chronic urticaria. Provocation test].

    Science.gov (United States)

    Giménez Camarasa, J M

    1976-01-01

    Sixty patients of ages ranging from 11 to 64, with chronic urticaria from 2 months to 50 years duration, were studied with the provocation test. We found responses in 33.3% of patients. Tartrazine was the most common inducer, specially in those patients sensitive to aspirin with increased salicilate blood levels. As we did not use aspirin as inducer the results with tartrazine are more relevant and can be used to detect a positive response to aspirin. The relation between tartrazine and aspirin was not observed in patients with pressure or cholinergic urticaria. The provocation test is most useful in patients with chronic urticaria of unknown cause. 4 hydroxybenzoic acid and sodium acid and sodium benzoate were the more common inducers in the latter patients. We feel that the provocation test is a useful tool to study patients with chronic urticaria. Tartrazine, 4 hydroxybenzoic acid, sodium benzoate, tiramin and penicilin are included in the test. The responders should eliminate the offender from their diet.

  5. The Use of Paradoxical Intention: Self-Management through Laughter.

    Science.gov (United States)

    Lamb, C. Sue

    1980-01-01

    Paradoxical intention helps clients separate themselves from their neurotic symptoms. The client is instructed to exaggerate the symptom and finds, paradoxically, the symptom occurs less. In provocative exaggeration symptoms are described so as to evoke laughter at the very symptom that causes anxiety. (Author)

  6. On Provocation, Education and Entrepreneurship

    DEFF Research Database (Denmark)

    Hjorth, Daniel

    2011-01-01

    This essay develops an affect-based theory of entrepreneurial entrepreneurship education, something we summarise in a model of provocation-based entrepreneurial entrepreneurship education (the E3 model). Taking its starting point in an anecdote that illustrates the importance of provocation...... in processes of learning entrepreneurship, this article responds to previous calls for less economised entrepreneurship education focusing on its creative-relational nature. An affect-based theory of E3 brings together provocation, deterritorialisation (uprooting) and decoding/imagination, which calls for both...... critique and creativity, and resonates with appreciations of paralogy as driver in learning processes. The implications of this conceptual model of learning entrepreneurship entrepreneurially are discussed, with particular focus on the role of the pedagogue and on the future of learning entrepreneurship....

  7. Inhaled Mannitol as a Laryngeal and Bronchial Provocation Test.

    Science.gov (United States)

    Tay, Tunn Ren; Hoy, Ryan; Richards, Amanda L; Paddle, Paul; Hew, Mark

    2017-03-01

    Timely diagnosis of vocal cord dysfunction (VCD), more recently termed "inducible laryngeal obstruction," is important because VCD is often misdiagnosed as asthma, resulting in delayed diagnosis and inappropriate treatment. Visualization of paradoxical vocal cord movement on laryngoscopy is the gold standard for diagnosis, but is limited by poor test sensitivity. Provocation tests may improve the diagnosis of VCD, but the diagnostic performance of current tests is less than ideal. Alternative provocation tests are required. This pilot study demonstrates the feasibility of using inhaled mannitol for concurrent investigation of laryngeal and bronchial hyperresponsiveness. Consecutive patients with suspected VCD seen at our institution's asthma clinic underwent flexible laryngoscopy at baseline and following mannitol challenge. VCD was diagnosed on laryngoscopy based on inspiratory adduction, or >50% expiratory adduction of the vocal cords. Bronchial hyperresponsiveness after mannitol challenge was also assessed. We evaluated the interrater agreement of postmannitol laryngoscopy between respiratory specialists and laryngologists. Fourteen patients with suspected VCD in the context of asthma evaluation were included in the study. Mannitol provocation demonstrated VCD in three of the seven patients with normal baseline laryngoscopy (42.9%). Only two patients had bronchial hyperresponsiveness. There was substantial interrater agreement between respiratory specialists and laryngologists, kappa = 0.696 (95% confidence interval: 0.324-1) (P = 0.006). Inhaled mannitol can be used to induce VCD. It is well tolerated and can evaluate laryngeal and bronchial hyperresponsiveness at the same setting. Copyright © 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  8. Identity paradoxes

    Directory of Open Access Journals (Sweden)

    Đurić Jelena

    2010-01-01

    Full Text Available The article considers paradoxical nature of identity that emerges from: 1 the very concept of identity whose abstract generality unites various and even opposite features; 2 the processual nature of reality that is easier to express in the poetical metaphors or abstract principles than in unambiguous conceptual networks; 3 the oppose relationship between being and knowledge, mind and matter, subject and object, self and personality. Entangled in the labyrinth which evade efforts to be conceptually defined, the modern thinking of identity moves towards abandoning the idea of “self” on behalf of the “ego” and towards the misapprehension of identity as being identical. This corresponds to the “time of the lost spirit” stretched between the simultaneous need to find an identity and to give it up.

  9. Idiopathic decreased bispectral index during anaesthesia emergence: Possible causes for the phenomenon of paradoxical arousal.

    Science.gov (United States)

    Zaldibar-Gerrikagoitia Bilbao, J; González García, J; Romero Menchaca, O; Bernas Albeniz, A; Aguilera Celorrio, L

    2017-10-01

    In a small percentage of patients, sound, touch and even nociceptive stimulation in the presence of a light anaesthetic depth does not cause an electroencephalogram wave pattern of cortical activation (α, β waves) as would be expected, but leads to a slowed electroencephalogram pattern instead. We report the case of a patient who on emerging from anaesthesia showed very slowed brain activity on the electroencephalogram and reduced algorithmic value, that lasted approximately 5min coinciding with sound and tactile stimulation. After keeping her under observation for 24h during the postoperative period she did not present any brain disorder that could justify that event. Copyright © 2017 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Publicado por Elsevier España, S.L.U. All rights reserved.

  10. Promotor(a)s, the organizations in which they work, and an emerging paradox: how organizational structure and scope impact promotor(a)s' work.

    Science.gov (United States)

    May, Marlynn L; Contreras, Ricardo B

    2007-07-01

    To analyze how organizational structures and scope (geographic and programmatic) generate dissonance between the organization and its workers, creating a paradox with policy implications for access to health care in hard-to-reach populations. The workers are lay community health workers called promotor(a)s. The organizations are community based organizations in which the promotor(a)s work, either as volunteers, part-time or as full-time wage staff. Ethnographic study of 12 organizations and their promotor(a)s. Data gathering included interviews with organization directors, promotor(a)s, service providers working with the organizations, and community residents served by the organizations and workers. In addition, promotor(a)s were observed in the course of their work. Sampling was a non-probability, snowball procedure for identifying the organizations and the workers within them. A paradox is emerging between (a) promotor(a)s who perceive their work to be locally focused and tightly integrated with the communities they serve and live in, and (b) the employing organizations that are expanding in geographical and programmatic scope because the work promotor(a)s do is in increasing demand by agencies and funding sources external to the communities served. The paradox potentially threatens to undermine and transform the work and working environment of the promotor(a)s. The challenge is to find a balance that will sustain a workable and working relationship among the organization, the workers, and the communities served. Care is needed in setting out policies that translate the paradox into greater congruence among organization, workers and communities. Policy needs discussed focus on (a) worker training, (b) worker employment and deployment, and (c) funding source recognition of the paradox.

  11. Towards a social practice theory of paradox

    OpenAIRE

    Le, J. K.; Bednarek, Rebecca

    2016-01-01

    This paper explores the shared ontological basis of the paradox and practices perspectives. Advancing the emerging ‘practice turn’ in paradox, we outline the practice-theoretical approach to studying paradox, articulating four main principles that define its research agenda. We describe each theoretical principle, explain its implications for the way we understand and study paradox, and illustrate it with an example of existing work. Next, we use these principles to reflect on the potential o...

  12. Paradoxical therapy in conversion reaction.

    OpenAIRE

    Ataoglu, Ahmet; Ozcetin, Adnan; Icmeli, Celalettin; Ozbulut, Omer

    2003-01-01

    Paradoxical therapy consists of suggesting that the patient intentionally engages in the unwanted behaviour such as performing compulsive ritual or wanting a conversion attack. In this study, the subjects were selected by the emergency unit psychiatrist from patients who were admitted to the emergency unit with pseudoseizure. The diagnoses was based on DSM-IV criteria. Paradoxical intention was applied to half of the 30 patients with conversion disorders; the other half were treated with diaz...

  13. Euthanasia: moral paradoxes.

    Science.gov (United States)

    ten Have, H A

    2001-11-01

    Over the past 30 years, euthanasia has been under continuous debate in The Netherlands. This contribution aims to provide a moral assessment of this debate. It is argued that euthanasia should be understood within a historical context, as a protest against medical power and as a way to bring about good death. Within the euthanasia debate, two paradoxes are identified which make the issue inherently complex and hard to regulate. The first paradox results from the dialectical relation between individual autonomy and relief of suffering as the major justifications of euthanasia. Although euthanasia represents an ultimate effort to give the individual patient control over his dying, the result of the debate is an increase of medical power. The second paradox is that although euthanasia emerged from a commitment to good death, it is resulting in a reduced range of options to bring about good death.

  14. Interpretation of growth hormone provocative tests

    DEFF Research Database (Denmark)

    Andersson, A M; Orskov, H; Ranke, M B

    1995-01-01

    To compare interpretations of growth hormone (GH) provocative tests in laboratories using six different GH immunoassays (one enzymeimmunometric assay (EIMA, assay 1), one immunoradiometric assay (IRMA, assay 5), one time-resolved fluorimmunometric assay (TRFIA, assay 3) and three radioimmunoassays...... (RIAs, assays 2, 4 and 6)), aliquots of peak samples from GH provocative tests were distributed between the four participating laboratories, quantified in the respective immunoassays and interpreted according to the cut-off values for provocative tests defined for each assay method. There was a high...

  15. Aesthetic, Functional and Conceptual Provocation in Research Through Design

    DEFF Research Database (Denmark)

    Raptis, Dimitrios; Jensen, Rikke Hagensby; Kjeldskov, Jesper

    2017-01-01

    how to use provocation in research through design. Towards this end, we report on a field study with four families that used an aesthetically, functionally and conceptually provocative future probe. The purpose of the probe was to challenge existing energy consuming practices through provocation...... and make its users reflect on them. The paper describes how all three provocative aspects were addressed, and our findings demonstrate how they were experienced in the real world, and how they impacted our research through design approach. We conclude by presenting reflections on how to design provocations......, and reflections on the impact of provocations for research through design in general....

  16. Reframing Practice through Provocative Co-design

    DEFF Research Database (Denmark)

    Christiansen, Lotte; Poulsen, Søren Bolvig; Morelli, Nicola

    2013-01-01

    changes in organisations, as it has the ability to force a shift in face (Goffman 1967) and the potential to motivate and enable stakeholders to reframe practice and initiate change initiatives. This is done by focusing on a service design project in which a provocative assignment in a co-design workshop...... triggered a key stakeholder to implement a change in an existing service in a public hospital. However, we will also argue that provocation should be supported with a dynamic attitude from the designer in the social interaction....

  17. Paradoxical therapy in conversion reaction.

    Science.gov (United States)

    Ataoglu, Ahmet; Ozcetin, Adnan; Icmeli, Celalettin; Ozbulut, Omer

    2003-08-01

    Paradoxical therapy consists of suggesting that the patient intentionally engages in the unwanted behaviour such as performing compulsive ritual or wanting a conversion attack. In this study, the subjects were selected by the emergency unit psychiatrist from patients who were admitted to the emergency unit with pseudoseizure. The diagnoses was based on DSM-IV criteria. Paradoxical intention was applied to half of the 30 patients with conversion disorders; the other half were treated with diazepam in order to examine the efficiency of the paradoxical intention versus diazepam. In both groups the differences of the anxiety scores at the beginning of the study were found to be insignificant (z=1.08, p=0.28). Of the 15 patients who completed paradoxical intention treatment, 14 (93.3%) responded favorably to paradoxical intention. On the other hand of 15 patients who completed diazepam therapy, 9 (60%) responded well to therapy and 6 patients carried on their conversion symptoms at the end of 6 weeks. Paradoxical intention-treated patients appeared to have greater improvements in anxiety scores (z=2.43, pparadoxical intention can be effective in the treatment of conversion disorder.

  18. The hyperventilation provocation test in panic disorder

    NARCIS (Netherlands)

    Spinhoven, P.; Onstein, E. J.; Sterk, P. J.; Le Haen-Versteijnen, D.

    1992-01-01

    Forty-eight patients with DSM-III-R Panic Disorder underwent a hyperventilation provocation Test (HVPT). Twenty-four patients rated the symptoms induced during the HVPT as similar to those occurring during panic attacks in daily life. Contrary to the classical hyperventilation model of panic, no

  19. Provocative behavior of a victim and its difference from the provocation of a crime

    Directory of Open Access Journals (Sweden)

    Valeriy Anatolyevich Cherepakhin

    2015-03-01

    Full Text Available Objective to define the main elements of provocative behavior of a victim and its difference from the provocation of a crime. Methods dialectic approach to the study of social phenomena and historical and comparativelegal methods for the study of legal reality. Results scientific grounding of theoreticallegal bases of the ldquoprovocationrdquo institution and formulating proposals for improving its legislative regulation and increasing the efficiency of its law enforcement. Scientific novelty the article presents the author39s classification of the types and forms of provocative activity in the norms of both the General and the Specific parts. Practical value summarizing and analysis of the modern empirical data on the practice of implementation of the norms containing the features of provocation and elaboration of organizational and methodological recommendations based on the authorrsquos research. nbsp

  20. Aesthetic, Functional and Conceptual Provocation in Research Through Design

    DEFF Research Database (Denmark)

    Raptis, Dimitrios; Jensen, Rikke Hagensby; Kjeldskov, Jesper

    2017-01-01

    how to use provocation in research through design. Towards this end, we report on a field study with four families that used an aesthetically, functionally and conceptually provocative future probe. The purpose of the probe was to challenge existing energy consuming practices through provocation...... and make its users reflect on them. The paper describes how all three provocative aspects were addressed, and our findings demonstrate how they were experienced in the real world, and how they impacted our research through design approach. We conclude by presenting reflections on how to design provocations...

  1. The effects of body mass index on complications and mortality after emergency abdominal operations: The obesity paradox.

    Science.gov (United States)

    Benjamin, Elizabeth R; Dilektasli, Evren; Haltmeier, Tobias; Beale, Elizabeth; Inaba, Kenji; Demetriades, Demetrios

    2017-11-01

    Recent literature suggests that obesity is protective in critically illness. This study addresses the effect of BMI on outcomes after emergency abdominal surgery (EAS). Retrospective, ACS-NSQIP analysis. All patients that underwent EAS were included. The study population was divided into five groups based on BMI; regression models were used to evaluate the role of obesity in morbidity and mortality. 101,078 patients underwent EAS; morbidity and mortality were 19.5% and 4.5%, respectively. Adjusted mortality was higher in underweight patients (AOR 1.92), but significantly lower in all obesity groups (AOR's 0.73, 0.66, 0.70, 0.70 respectively). Underweight and class III obesity was associated with increased complications (AOR 1.47 and 1.30), while mild obesity was protective (AOR 0.92). Underweight patients undergoing EAS have increased morbidity and mortality. Although class III obesity is associated with increased morbidity, overweight and class I obesity were protective. All grades of obesity may be protective against mortality after EAS relative to normal weight patients. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Nasal provocation test using allergen extract versus cold dry air provocation test: which and when?

    Science.gov (United States)

    Kim, Young Hyo; Jang, Tae Young

    2013-01-01

    Nasal provocation tests (NPTs) are useful for evaluation of patients with allergic rhinitis. The cold dry air (CDA) provocation test is useful for evaluation of patients with nonspecific nasal hyperreactivity (NHR). This study aimed to determine whether the NPT or CDA provocation would be more useful for patients with different clinical pictures. We evaluated changes in nasal symptoms (visual analog scale [VAS]) and acoustic parameters after NPT or CDA provocation in healthy volunteers (group A, n = 27), patients with allergic rhinitis (group B, n = 20), and subjects with nonallergic rhinitis (group C, n = 26). According to their subjective cold hyperresponsiveness (SCH), we compared changes in VAS and acoustic parameters after each protocol. The correlation between results of the skin-prick test (SPT) and changes in VAS after each protocol was analyzed. Finally, we performed an analysis of correlation between NPT and CDA provocation. After NPT, group B showed a larger change in VAS for rhinorrhea, sneezing, and itching (p < 0.01). After CDA challenge, the change in VAS for nasal obstruction was larger in group C (p < 0.05). Changes in acoustic parameters were larger in groups B and C after NPT (p < 0.01). After CDA challenge, the SCH(+) group (n = 49) showed a larger decrease of acoustic parameters than the SCH(-) group (n = 24; p < 0.01). Significant correlation was observed between the size of SPT and degree of change in VAS after NPT. No significant correlation was observed between NPT and CDA. CDA could be an adjunct tool for evaluating NHR in patients with self-reported SCH.

  3. Philosophical Provocation: The Lifeblood of Clinical Ethics.

    Science.gov (United States)

    McCullough, Laurence B

    2017-02-01

    The daily work of the clinical ethics teacher and clinical ethics consultant falls into the routine of classifying clinical cases by ethical type and proposing ethically justified alternatives for the professionally responsible management of a specific type of case. Settling too far into this routine creates the risk of philosophical inertia, which is not good either for the clinical ethicist or for the field of clinical ethics. The antidote to this philosophical inertia and resultant blinkered vision of clinical ethics is sustained, willing exposure to philosophical provocation. The papers in this clinical ethics issue of the Journal of Medicine and Philosophy provide just such philosophical provocation related to core topics in clinical ethics: the distinction between clinical practice and clinical research; telemedicine, or medicine at a distance; illness narratives; the concept of the placebo effect; and sex reassignment. © The Author 2017. Published by Oxford University Press, on behalf of the Journal of Medicine and Philosophy Inc. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  4. Concussion Recovery Phase Affects Vestibular and Oculomotor Symptom Provocation.

    Science.gov (United States)

    Cheever, Kelly M; McDevitt, Jane; Tierney, Ryan; Wright, W Geoffrey

    2017-11-30

    Vestibular and oculomotor testing is emerging as a valuable assessment in sport-related concussion (SRC). However, their usefulness for tracking recovery and guiding return-to-play decisions remains unclear. Therefore the purpose of this study was to evaluate their clinical usefulness for tracking SRC recovery. Vestibular and oculomotor assessments were used to measure symptom provocation in an acute group (n=21) concussed≤10 days, prolonged symptoms group (n=10) concussed ≥16 days (median=84 days), healthy group (n=58) no concussions in >6 months. Known-groups approach was used with three groups at three time points (initial, 2-week and 6-week follow-up). Provoked symptoms for Gaze-Stabilization (GST), Rapid Eye Horizontal (REH), Optokinetic Stimulation (OKS), Smooth-Pursuit Slow (SPS) and Fast (SPF) tests, total combined symptoms scores and near point convergence (NPC) distance were significantly greater at initial assessment in both injury groups compared to controls. Injury groups improved on the King-Devick test and combined symptom provocation scores across time. The acute group improved over time on REH and SPF tests, while the prolonged symptoms group improved on OKS. A regression model (REH, OKS, GST) was 90% accurate discriminating concussed from healthy. Vestibular and ocular motor tests give valuable insight during recovery. They can prove beneficial in concussion evaluation given the modest equipment, training and time requirements. The current study demonstrates that when combined, vestibular and oculomotor clinical tests aid in the detection of deficits following a SRC. Additionally, tests such as NPC, GST, REH, SPS, SPF OKS and KD provide valuable information to clinicians throughout the recovery process and may aid in return to play decisions. © Georg Thieme Verlag KG Stuttgart · New York.

  5. The Power of the Provocative: Exploring World History Content

    Science.gov (United States)

    Ashkettle, Bryan L.

    2013-01-01

    This study addresses how my freshman world history students come to understand controversial issues as provocative within the secondary social studies classroom, and in what ways does their engagement with provocative issues influence their understanding of the content and the world around them. In addition, this research study seeks to discover…

  6. Solutions to Organizational Paradox

    DEFF Research Database (Denmark)

    Li, Xin; Worm, Verner; Peihong, Xie

    Organizations face all kinds of paradoxical problems. There exist various solutions to organizational paradoxes. We develop a typology that lists nine possible logical approaches to understanding the relationship between paradoxical opposites, out of which we identify five types of solutions...... to organizational paradox. Four of the five solutions are explicitly associated with four prominent philosophies. We show the relevance of the five solutions to the real world by applying our scheme to understand different solutions to the generic strategy paradox. Finally, we address the question whether...

  7. Hostile attribution biases for relationally provocative situations and event-related potentials.

    Science.gov (United States)

    Godleski, Stephanie A; Ostrov, Jamie M; Houston, Rebecca J; Schlienz, Nicolas J

    2010-04-01

    This exploratory study investigates how hostile attribution biases for relationally provocative situations may be related to neurocognitive processing using the P300 event-related potential. Participants were 112 (45 women) emerging adults enrolled in a large, public university in upstate New York. Participants completed self-report measures on relational aggression and hostile attribution biases and performed an auditory perseveration task to elicit the P300. It was found that hostile attribution biases for relational provocation situations was associated with a larger P300 amplitude above and beyond the role of hostile attribution biases for instrumental situations, relational aggression, and gender. Larger P300 amplitude is interpreted to reflect greater allocation of cognitive resources or enhanced "attending" to salient stimuli. Implications for methodological approaches to studying aggression and hostile attribution biases and for theory are discussed, as well as implications for the fields of developmental psychology and psychopathology. Copyright 2010 Elsevier B.V. All rights reserved.

  8. The Obesity Paradox in Cancer: a Review.

    Science.gov (United States)

    Lennon, Hannah; Sperrin, Matthew; Badrick, Ellena; Renehan, Andrew G

    2016-09-01

    There is a common perception that excess adiposity, commonly approximated by body mass index (BMI), is associated with reduced cancer survival. A number of studies have emerged challenging this by demonstrating that overweight and early obese states are associated with improved survival. This finding is termed the "obesity paradox" and is well recognized in the cardio-metabolic literature but less so in oncology. Here, we summarize the epidemiological findings related to the obesity paradox in cancer. Our review highlights that many observations of the obesity paradox in cancer reflect methodological mechanisms including the crudeness of BMI as an obesity measure, confounding, detection bias, reverse causality, and a specific form of the selection bias, known as collider bias. It is imperative for the oncologist to interpret the observation of the obesity paradox against the above methodological framework and avoid the misinterpretation that being obese might be "good" or "protective" for cancer patients.

  9. Mathematical fallacies and paradoxes

    CERN Document Server

    Bunch, Bryan

    1982-01-01

    Stimulating, thought-provoking analysis of the most interesting intellectual inconsistencies in mathematics, physics, and language, including being led astray by algebra (De Morgan's paradox). 1982 edition.

  10. Odor provocation test for laryngeal hypersensitivity.

    Science.gov (United States)

    Gartner-Schmidt, Jackie L; Rosen, Clark A; Radhakrishnan, Nandhakumar; Ferguson, Berrylin J

    2008-05-01

    This study was to present an odor provocation/challenge test for laryngeal hypersensitivity in a suspected odor induced dysphonic patient. The second aim was to rule out secondary gain from organic laryngeal hypersensitivity. Two steps were taken for this purpose. First, because the evaluation of hypersensitivity may be affected by the perception of odor, the study investigated laryngeal hypersensitivity during nasal and oral breathing separately to disentangle possible cognitive reactions to odors. Second, a healthy control (HC) participant was used with the identical testing protocol for nasal breathing to minimize unbiased results. The HC's response to nasal breathing of the odors showed no response to all the stimuli. The participant with possible secondary gain issues responded differently to the odors when presented nasally versus orally. Oral breathing showed less severe and less frequent laryngeal hypersensitive reactions. This suggests that laryngeal hypersensitivity was either due to the odor, cognitive information, sensory changes in olfaction leading to psychological conditioning, or for any possible secondary gain. Hence, it is difficult to indicate the precise reason (cause and effect) for the participant's laryngeal hypersensitivity; however, this study describes the first structured, controlled, repeatable, and randomized design to investigate odor induced laryngeal hypersensitivity and decipher possible secondary gain from true laryngeal hypersensitivity.

  11. Paradoxes in dermatology

    Directory of Open Access Journals (Sweden)

    Keshavmurthy A Adya

    2013-01-01

    Full Text Available Many paradoxical phenomena related to clinical, immunological, and therapeutic dermatology have been described. While some of them can be explained logically, the cause for others can only be speculated. Whenever encountered in clinical practice, background knowledge of such paradoxes may be useful to the clinician.

  12. Twin Paradox and Causality

    OpenAIRE

    Grandou, T.; Rubin, J.L.

    2007-01-01

    After pointing out the historical avatar at the origin of a would be twin or clock paradox, we argue that, at least on a local scale, the (re-qualified) paradox is but a necessary consequence of the sole principle of causality.

  13. Habitual Starvation and Provocative Behaviors: Two Potential Routes to Extreme Suicidal Behavior in Anorexia Nervosa

    Science.gov (United States)

    Selby, Edward A.; Smith, April R.; Bulik, Cynthia M.; Olmsted, Marion P.; Thornton, Laura; McFarlane, Traci L.; Berrettini, Wade H.; Brandt, Harry A.; Crawford, Steve; Fichter, Manfred M.; Halmi, Katherine A.; Jacoby, Georg E.; Johnson, Craig L.; Jones, Ian; Kaplan, Allan S.; Mitchell, James E.; Nutzinger, Detlev O.; Strober, Michael; Treasure, Janet; Woodside, D. Blake; Kaye, Walter H.; Joiner, Thomas E.

    2016-01-01

    Anorexia nervosa (AN) is perhaps the most lethal mental disorder, in part due to starvation-related health problems, but especially because of high suicide rates. One potential reason for high suicide rates in AN may be that those affected face pain and provocation on many fronts, which may in turn reduce their fear of pain and thereby increase risk for death by suicide. The purpose of the following studies was to explore whether repetitive exposure to painful and destructive behaviors such as vomiting, laxative use, and non-suicidal self-injury (NSSI) was a mechanism that linked AN-binge-purging (ANBP) subtype, as opposed to AN-restricting subtype (ANR), to extreme suicidal behavior. Study 1 utilized a sample of 787 individuals diagnosed with one or the other subtype of AN, and structural equation modeling results supported provocative behaviors as a mechanism linking ANBP to suicidal behavior. A second, unexpected mechanism emerged linking ANR to suicidal behavior via restricting. Study 2, which used a sample of 249 AN patients, replicated these findings, including the second mechanism linking ANR to suicide attempts. Two potential routes to suicidal behavior in AN appear to have been identified: one route through repetitive experience with provocative behaviors for ANBP, and a second for exposure to pain through the starvation of restricting in ANR. PMID:20398895

  14. Paradoxes in probability theory

    CERN Document Server

    Eckhardt, William

    2013-01-01

    Paradoxes provide a vehicle for exposing misinterpretations and misapplications of accepted principles. This book discusses seven paradoxes surrounding probability theory.  Some remain the focus of controversy; others have allegedly been solved, however the accepted solutions are demonstrably incorrect. Each paradox is shown to rest on one or more fallacies.  Instead of the esoteric, idiosyncratic, and untested methods that have been brought to bear on these problems, the book invokes uncontroversial probability principles, acceptable both to frequentists and subjectivists. The philosophical disputation inspired by these paradoxes is shown to be misguided and unnecessary; for instance, startling claims concerning human destiny and the nature of reality are directly related to fallacious reasoning in a betting paradox, and a problem analyzed in philosophy journals is resolved by means of a computer program.

  15. Quantum Quasi-Paradoxes and Quantum Sorites Paradoxes

    Directory of Open Access Journals (Sweden)

    Smarandache F.

    2005-04-01

    Full Text Available There can be generated many paradoxes or quasi-paradoxes that may occur from the combination of quantum and non-quantum worlds in physics. Even the passage from the micro-cosmos to the macro-cosmos, and reciprocally, can generate unsolved questions or counter-intuitive ideas. We define a quasi-paradox as a statement which has a prima facie self-contradictory support or an explicit contradiction, but which is not completely proven as a paradox. We present herein four elementary quantum quasi-paradoxes and their corresponding quantum Sorites paradoxes, which form a class of quantum quasi-paradoxes.

  16. Quantum Quasi-Paradoxes and Quantum Sorites Paradoxes

    CERN Document Server

    Smarandache, F

    1997-01-01

    There can be generated many paradoxes or quasi-paradoxes that may occur from the combination of quantum and non-quantum worlds in physics. Even the passage from the micro-cosmos to the macro-cosmos, and reciprocally, can generate unsolved questions or counter-intuitive ideas. We define a quasi-paradox as a statement which has a prima facie self-contradictory support or an explicit contradiction, but which is not completely proven as a paradox. We present herein four elementary quantum quasi-paradoxes and their corresponding quantum Sorites paradoxes, which form a class of quantum quasi-paradoxes.

  17. Can magnetic resonance imaging accurately predict concordant pain provocation during provocative disc injection?

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Chang Ho; Kim, Yun Hwan; Kim, Jung Hyuk; Chung, Kyoo Byung; Sung, Deuk Jae [Korea University Anam Hospital, Korea University College of Medicine, Department of Radiology, Seoul (Korea); Lee, Sang-Heon [Korea University Anam Hospital, Korea University College of Medicine, Department of Physical Medicine and Rehabilitation, Seoul (Korea); Derby, Richard [Spinal Diagnostics and Treatment Center, Daly City, CA (United States); Stanford University Medical Center, Division of Physical Medicine and Rehabilitation, Stanford, CA (United States)

    2009-09-15

    To correlate magnetic resonance (MR) image findings with pain response by provocation discography in patients with discogenic low back pain, with an emphasis on the combination analysis of a high intensity zone (HIZ) and disc contour abnormalities. Sixty-two patients (aged 17-68 years) with axial low back pain that was likely to be disc related underwent lumbar discography (178 discs tested). The MR images were evaluated for disc degeneration, disc contour abnormalities, HIZ, and endplate abnormalities. Based on the combination of an HIZ and disc contour abnormalities, four classes were determined: (1) normal or bulging disc without HIZ; (2) normal or bulging disc with HIZ; (3) disc protrusion without HIZ; (4) disc protrusion with HIZ. These MR image findings and a new combined MR classification were analyzed in the base of concordant pain determined by discography. Disc protrusion with HIZ [sensitivity 45.5%; specificity 97.8%; positive predictive value (PPV), 87.0%] correlated significantly with concordant pain provocation (P < 0.01). A normal or bulging disc with HIZ was not associated with reproduction of pain. Disc degeneration (sensitivity 95.4%; specificity 38.8%; PPV 33.9%), disc protrusion (sensitivity 68.2%; specificity 80.6%; PPV 53.6%), and HIZ (sensitivity 56.8%; specificity 83.6%; PPV 53.2%) were not helpful in the identification of a disc with concordant pain. The proposed MR classification is useful to predict a disc with concordant pain. Disc protrusion with HIZ on MR imaging predicted positive discography in patients with discogenic low back pain. (orig.)

  18. A Quantum Twin Paradox

    CERN Document Server

    ludwin, Doron

    2011-01-01

    The Classical Twin Paradox is widely dealt in literature and neatly resolved. In addition, it is also well known that, when looking at two systems which are boosted relative to each other, the concept of the simultaneous effect of a quantum measurement in space-time causes some discrepancies in the cause-effect behavior. However, these discrepancies have been thought not to cause any apparent paradox except for violating the Free-Will postulate. In this paper we suggest that using the local t axis, all over space, as the axis in which the quantum measurement is thought to be simultaneous, we do reach a kind of true "Twin Paradox". The resolution of this paradox requires the introduction of a global proper time into a covariant quantum theory.

  19. The Condorcet paradox revisited

    NARCIS (Netherlands)

    Herings, P.J.J.; Houba, H

    2013-01-01

    We analyze the Condorcet paradox within a strategic bargaining model with majority voting, exogenous recognition probabilities, and no discounting. Stationary subgame perfect equilibria (SSPE) exist whenever the geometric mean of the players' risk coefficients, ratios of utility differences between

  20. The twin paradox revisited

    Science.gov (United States)

    Dray, Tevian

    1990-09-01

    The twin paradox of special relativity results from failing to recognize the fundamental asymmetry between the two twins: One and only one twin changes direction and thus undergoes acceleration. What happens if the universe is closed, so that the twin in the rocket can return to Earth without changing direction? The twin paradox is reformulated in a closed universe (a cylinder) and then resolved by showing that there is still a (much more subtle!) asymmetry between the two twins.

  1. TOPOLOGICAL AGGREGATION, THE TWIN PARADOX AND THE NO SHOW PARADOX

    OpenAIRE

    Chèze, Guillaume

    2016-01-01

    Consider the framework of topological aggregation introduced by Chichilnisky (1980). We prove that in this framework the Twin Paradox and the No Show Paradox cannot be avoided. Anonymity and unanimity are not needed to obtain these results.

  2. Provocation, Hostility, Aggression, and Victimization: Firefighters and Incarcerated Felons.

    Science.gov (United States)

    Alexander, E. Carlene; And Others

    1995-01-01

    Examines self-reported histories of victimization among two groups of men. Violence, provocation, hostility, and aggression inventories were administered to a prosocial group of firefighters and an antisocial group of incarcerated felons. Fourteen of the 15 possible behavioral-abuse correlations were significant when both groups were considered…

  3. Provocative Pedagogies in e-Learning: Making the Invisible Visible

    Science.gov (United States)

    Sinclair, Anne

    2009-01-01

    The purpose of this case study was to explore the experiences of participants (practicing teachers) involved in an online course entitled: "Reflective Practice for Teachers." Using a provocative pedagogy in the course, the teachers were challenged to confront beliefs and assumptions about teaching and learning and become active participants in the…

  4. Specificity and sensitivity assessment of selected nasal provocation testing techniques

    Directory of Open Access Journals (Sweden)

    Edyta Krzych-Fałta

    2016-12-01

    Full Text Available Introduction: Nasal provocation testing involves an allergen-specific local reaction of the nasal mucosa to the administered allergen. Aim: To determine the most objective nasal occlusion assessment technique that could be used in nasal provocation testing. Material and methods : A total of 60 subjects, including 30 patients diagnosed with allergy to common environmental allergens and 30 healthy subjects were enrolled into the study. The method used in the study was a nasal provocation test with an allergen, with a standard dose of a control solution and an allergen (5,000 SBU/ml administered using a calibrated atomizer into both nostrils at room temperature. Early-phase nasal mucosa response in the early phase of the allergic reaction was assessed via acoustic rhinometry, optical rhinometry, nitric oxide in nasal air, and tryptase levels in the nasal lavage fluid. Results : In estimating the homogeneity of the average values, the Levene’s test was used and receiver operating characteristic curves were plotted for all the methods used for assessing the nasal provocation test with an allergen. Statistically significant results were defined for p < 0.05. Of all the objective assessment techniques, the most sensitive and characteristic ones were the optical rhinometry techniques (specificity = 1, sensitivity = 1, AUC = 1, PPV = 1, NPV = 1. Conclusions : The techniques used showed significant differences between the group of patients with allergic rhinitis and the control group. Of all the objective assessment techniques, those most sensitive and characteristic were the optical rhinometry.

  5. Provocative design for unprovocative designers : Strategies for triggering personal dilemmas

    NARCIS (Netherlands)

    Ozkaramanli, D.; Desmet, P.M.A.; Lloyd, Peter; Bohemia, Erik

    2016-01-01

    Traditional design approaches stimulate the creation of products that make daily interactions more efficient, comfortable, and pleasant. In contrast, provocative design approaches, such as critical design, have a different focus: they aim to challenge the status quo through products that expose

  6. Discontinuation of tube feeding in young children by hunger provocation

    NARCIS (Netherlands)

    Kindermann, Angelika; Kneepkens, Corneille Marie Francois; Stok, Anita; van Dijk, Elisabeth Maria; Engels, Michelle; Douwes, Adriaan Cornelis

    2008-01-01

    OBJECTIVES: Pathological food refusal (PFR) is not rare in young children with chronic conditions requiring prolonged tube feeding. We investigated whether these children could be weaned from tube feeding with a multidisciplinary hunger provocation program. PATIENTS AND METHODS: The study included

  7. Zeno's Paradox of Immortality.

    Science.gov (United States)

    Olshansky, S Jay; Carnes, Bruce A

    2013-01-01

    Scientists who speculate on the future of human longevity have a broad range of views ranging from the promise of immortality, to radical life extension, to declines in life expectancy. Among those who contend that radical life extension is already here, or on the horizon, or immortality is forthcoming, elements of their reasoning appear surprisingly close, if not identical, to a famous mathematical paradox posed by the ancient Greek mathematician known as Zeno. Here we examine the underlying assumptions behind the views that much longer life expectancies are forthcoming or have already arrived, and place their line of reasoning within the context of a new Zeno paradox described here as The Paradox of Immortality. Copyright © 2012 S. Karger AG, Basel.

  8. The Effects of a Provocation on Aggression for Three Types of Alcohol Users.

    Science.gov (United States)

    Baldwin, Joseph J.; Randoph, Daniel Lee

    1982-01-01

    Investigated the effects of a provocation on aggression for three types of alcohol users. The results indicated that the provocation elicited significantly more feelings of hostility and verbal aggression. However, there were no significant level effects, nor a significant interaction between level of drinking and presence of a provocation.…

  9. A Quantum Twin Paradox

    OpenAIRE

    ludwin, Doron

    2011-01-01

    The Classical Twin Paradox is widely dealt in literature and neatly resolved. In addition, it is also well known that, when looking at two systems which are boosted relative to each other, the concept of the simultaneous effect of a quantum measurement in space-time causes some discrepancies in the cause-effect behavior. However, these discrepancies have been thought not to cause any apparent paradox except for violating the Free-Will postulate. In this paper we suggest that using the local t...

  10. Plant Provocations: Botanical Indigeneity and (Decolonial Imaginations

    Directory of Open Access Journals (Sweden)

    Narendran Kumarakulasingam

    Full Text Available Abstract Abstract: This paper examines the possibilities and limitations of an emergent global discourse of indigeneity to offer an oppositional praxis in the face of the depredations of settler colonialism in post-apartheid South Africa. Self-conscious articulations of indigeneity, we argue, reveal the fraught relationship between increasingly hegemonic and narrow understandings of the indigenous and the carceral logic of apartheid. We examine this by focusing on the meanings and attachments forged through indigenous plants in two realms: the world of indigenous gardening practised by white suburban dwellers and that of subsistence farming undertaken by rural black women. This juxtaposition reveals that in contrast to the pervasive resurrection of colonial time that defines metropolitan indigenous gardening, the social relations of a subsistence cultivator challenge the confines of colonial temporality, revealing a creative mode of dissent structured around dreams, ancestral knowledge, and the commons. Our exploration of struggles around botanical indigeneity suggests that anticolonial modes of indigeneity do not necessarily inhere in recognisable forms and that studies of the indigenous need to proceed beyond those that bear familial resemblance to emergent global understandings.

  11. The Lunar orbit paradox

    Directory of Open Access Journals (Sweden)

    Tomić Aleksandar S.

    2013-01-01

    Full Text Available Newton's formula for gravity force gives greather force intensity for atraction of the Moon by the Sun than atraction by the Earth. However, central body in lunar (primary orbit is the Earth. So appeared paradox which were ignored from competent specialist, because the most important problem, determination of lunar orbit, was inmediately solved sufficiently by mathematical ingeniosity - introducing the Sun as dominant body in the three body system by Delaunay, 1860. On this way the lunar orbit paradox were not canceled. Vujičić made a owerview of principles of mechanics in year 1998, in critical consideration. As an example for application of corrected procedure he was obtained gravity law in some different form, which gave possibility to cancel paradox of lunar orbit. The formula of Vujičić, with our small adaptation, content two type of acceleration - related to inertial mass and related to gravity mass. So appears carried information on the origin of the Moon, and paradox cancels.

  12. The happiness paradox

    NARCIS (Netherlands)

    Bollen, Johan; Gonçalves, Bruno; Leemput, van de Ingrid; Ruan, Guangchen

    2017-01-01

    Most individuals in social networks experience a so-called Friendship Paradox: they are less popular than their friends on average. This effect may explain recent findings that widespread social network media use leads to reduced happiness. However the relation between popularity and happiness is

  13. Postradiation hypertrichosis: A paradox

    Directory of Open Access Journals (Sweden)

    Jai Prakash Agarwal

    2014-01-01

    Full Text Available Alopecia due to radiation has remained a widely accepted aspect of radiotherapy. We present an unexpected clinical scenario, where a patient with left lung stage IIIB nonsmall cell adenocarcinoma, treated with radiochemotherapy achieved a complete response and developed an obscure late effect in terms of paradoxical hypertrichosis in the radiation portals. The paper presents plausible hypothesis for this unusual phenomenon.

  14. The Network Paradox

    National Research Council Canada - National Science Library

    David Rothkopf

    2015-01-01

    .... Call it the "network paradox," a phenomenon by which joining a network can both strengthen and create new vulnerabilities for those on the network. Setting aside hyperbole and simplistic visions is essential when planning for a future that is going to become dramatically different in many complex ways.

  15. Resolving the biodiversity paradox

    Science.gov (United States)

    James S. Clark; Mike Dieta; Sukhendu Chakraborty; Pankaj K.Ibeanez Agarwal; Shannon LaDeau; Mike Wolosin

    2007-01-01

    The paradox of biodiversity involves three elements, (i) mathematical models predict that species must differ in specific ways in order to coexist as stable ecological communities, (ii) such differences are difficult to identify, yet (iii) there is widespread evidence of stability in natural communities.

  16. The Simpson's paradox unraveled

    DEFF Research Database (Denmark)

    Hernán, Miguel A; Clayton, David; Keiding, Niels

    2011-01-01

    -matter knowledge. We also review previous explanations of Simpson’s paradox that attributed it to two distinct phenomena: confounding and non-collapsibility. Conclusion Analytical errors may occur when the problem is stripped of its causal context and analyzed merely in statistical terms....

  17. Adiposopathy and Obesity Paradox

    Directory of Open Access Journals (Sweden)

    Indriyanti Rafi Sukmawati

    2013-04-01

    Full Text Available BACKGROUND: Obesity has reached global epidemic proportions in both adults and children and is associated with numerous comorbidities, including hypertension, type 2 diabetes mellitus (T2DM, dyslipidemia and major cardiovascular diseases (CVD. CONTENT: Adiposity may cause adipocyte and adipose tissue anatomic and functional abnormalities, termed adiposopathy (adipose-opathy or "sick fat," that result in endocrine and immune derangements. Adiposopathy may directly contribute to CVD through pericardiac and perivascular effects on the myocardium and blood vessels. Adiposopathy may also indirectly contribute to CVD through promoting or worsening major CVD risk factors such as T2DM, high blood pressure, and dyslipidemia. Despite this adverse association, numerous studies have documented an obesity paradox in which overweight and obese people with established CVD, including hypertension, heart failure, coronary heart disease, and peripheral arterial disease, have a better prognosis compared with nonoverweight/nonobese patients. These paradoxical findings are made less paradoxical when the pathogenic potential of excessive body fat is assessed based on adipose tissue dysfunction rather than simply on increased fat mass alone. SUMMARY: Adiposopathy is defined as pathological adipose tissue function that may be promoted and exacerbated by fat accumulation (adiposity and sedentary lifestyle in genetically susceptible patients. Adiposopathy is a root cause of some of the most common metabolic diseases observed in clinical practice, including T2DM, hypertension and dyslipidemia. KEYWORDS: adiposopathy, adiposity, obesity paradox, adipocyte dysfunction, adipose hypertrophy, adipose hyperplasia.

  18. The Condorcet Paradox revisited

    NARCIS (Netherlands)

    Houba, H.E.D.; Herings, P.J.J.

    2016-01-01

    We analyze the Condorcet paradox within a strategic bargaining model with majority voting, exogenous recognition probabilities, and no discounting for the case with three players and three alternatives. Stationary subgame perfect equilibria (SSPE) exist whenever the geometric mean of the players’

  19. The commuting time paradox

    NARCIS (Netherlands)

    van Ommeren, J.N.; Rietveld, P.

    2005-01-01

    We examine the conditions for the 'commuting time paradox' which states that the average commuting time does not vary between different periods. We develop therefore an equilibrium job search model with endogenously chosen commuting costs. Presuming wage bargaining between workers and firms, the

  20. Intuitive Solutions to Relativistic Paradoxes

    Science.gov (United States)

    Hewett, Lionel D.

    2010-10-01

    Einstein's special theory of relativity is filled with so many apparent paradoxes that many people simply cannot accept its validity. They cannot believe that any theory filled with so many conceptual inconsistencies could possibly correlate with true reality. However, it is not the Theory of Relativity that is filled with paradoxes and inconsistencies but a person's intuitive interpretation of that theory. By simply changing one's perspective or viewpoint it is possible to acquire intuitive solutions to many of relativity's apparent paradoxes and to remove various conceptual inconsistencies commonly associated with the theory. This presentation illustrates how that intuition can be applied to such apparent paradoxes as the twin paradox, the pole-and-barn paradox, and even various paradoxes associated with spacetime itself.

  1. Reactivity to laboratory stress provocation predicts relapse to cocaine.

    Science.gov (United States)

    Back, Sudie E; Hartwell, Karen; DeSantis, Stacia M; Saladin, Michael; McRae-Clark, Aimee L; Price, Kimber L; Moran-Santa Maria, Megan M; Baker, Nathaniel L; Spratt, Eve; Kreek, Mary Jeanne; Brady, Kathleen T

    2010-01-01

    Cocaine dependence is a chronic relapsing disorder characterized by periods of abstinence and high rates of return to drug using behavior. Elevated levels of stress have been associated with relapse to cocaine; however, the nature of this association is not well understood. The relationship between reactivity to three human laboratory provocations and relapse to cocaine was investigated. Participants were 53 cocaine-dependent individuals who were admitted for a 2-day inpatient stay during which a psychosocial provocation (i.e., the Trier Social Stress Task), a pharmacological provocation (i.e., administration of 1 microg/kg corticotrophin releasing hormone; CRH), and a drug cue exposure paradigm were completed. Adrenocortico-trophic hormone (ACTH), cortisol, heart rate, and subjective cocaine craving and stress were assessed at baseline and at multiple time points post-task. Participants' cocaine use was monitored for approximately 1 month following testing. The majority (72.3%) of participants relapsed to cocaine during the follow-up period. In response to the CRH and drug cue exposure, elevated subjective craving and stress were significant predictors of cocaine use during follow-up. In response to the Trier, attenuated neuroendocrine responses were significant predictors of cocaine use. The findings provide further evidence of the ability of laboratory paradigms to predict relapse. The observed associations between stress reactivity and subsequent cocaine use highlight the clinical importance of the findings. Predictors of relapse may vary based on the type of provocation utilized. Interventions aimed at normalizing stress response, as measured using laboratory paradigms, may prove useful in relapse prevention. Published by Elsevier Ireland Ltd.

  2. A relativistic trolley paradox

    OpenAIRE

    Matvejev, Vadim N.; Matvejev, Oleg V.; Grøn, Ø.

    2016-01-01

    We present an apparent paradox within the special theory of relativity, involving a trolley with relativistic velocity and its rolling wheels. Two solutions are given, both making clear the physical reality of the Lorentz contraction, and that the distance on the rails between each time a specific point on the rim touches the rail is not equal to 2 p R ,where R is the radius of the wheel, but 2 p R = ffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffi...

  3. The Paradoxes of Liberalism

    DEFF Research Database (Denmark)

    Thompson, Grahame

    2011-01-01

    Jakob Vestergaard has produced one of the most telling analyses of the international financial architecture by deploying a broadly Foucauldian framework that invokes a novel description of neo-liberal governance, one organized around discipline, conditional exceptions and the pursuit of a ‘proper...... economy’. This review both welcomes but challenges some of Vestergaard's analysis. In so doing it explores further the paradoxes of liberalism and the fate of sovereignty in the current international context....

  4. Einstein and the twin paradox

    Science.gov (United States)

    Pesic, Peter

    2003-11-01

    Einstein was the first to discuss and resolve the 'twin paradox', which in 1905 he did not consider paradoxical and treated as a consequence of lack of simultaneity. He maintained this view until at least 1914. However, in 1918 Einstein brought forward arguments about accelerated frames of reference that tended to overshadow his initial resolution. His earlier arguments were gradually rediscovered during the subsequent controversy about this 'paradox'.

  5. Empathy Inhibits Aggression in Competition: The Role of Provocation, Emotion, and Gender.

    Science.gov (United States)

    Stanger, Nicholas; Kavussanu, Maria; McIntyre, David; Ring, Christopher

    2016-02-01

    Although the empathy-aggression relationship has been well documented, research has yet to establish whether emotions mediate and gender moderates this relationship in athletes, under conditions of low and high provocation. In this experiment, we assigned team-sport athletes to either a high (n = 40) or a low (n = 40) empathy group, and asked them to compete in a reaction-time task against a (fictitious) opponent, under conditions of low and high provocation. Empathy reduced aggression (i.e., intensity of electrical shock administered to the opponent) at low provocation in men, and at both low and high provocation in women. Guilt mediated the effect of empathy on aggression at low provocation in men; anger did not mediate any effects of empathy on aggression. Our findings indicate that the inhibitory effect of empathy on aggression and the mediating role of guilt are moderated by provocation and gender.

  6. 'Being sick a lot, often on each other': students' alcohol-related provocation.

    Science.gov (United States)

    Black, Lori F; Monrouxe, Lynn V

    2014-03-01

    Many medical students consume alcohol in excess, which can compromise their professionalism and increase their risk of future alcohol dependency. Just one study in Japan has examined the social influences of alcohol consumption among medical students. Eighty-six per cent (n = 821) of their respondents reported experiencing some form of alcohol-related harassment since the beginning of medical school. No similar research has been conducted in the UK. A cross-sectional online questionnaire of medical students at three British medical schools. In total, 216 students answered questions regarding their experiences of alcohol-related provocation (as targets and instigators), the rate of occurrence of events and their distress following acts of provocation. An open-ended question enabled respondents to report personal experiences of alcohol-related provocation. Seventy-five per cent (n = 162) of respondents reported experiencing alcohol-related provocation during the past year, with 49.1% (n = 106) reporting instigating acts of provocation. The most prevalent experience (both for targets and instigators) was coercion to drink an entire alcoholic beverage at once as part of a game. Most acts of alcohol-related provocation generated little or no distress. Males were significantly more likely to experience some events than females. Thirty-two personal narratives of alcohol-related provocation were reported (only three reported resisting provocation). Thematic analysis identified three themes with differing power relations: ongoing 'peer-peer provocation' as a commonplace social activity, hierarchical 'peer provocation' at initiation ceremonies and 'team-mate provocation' at sports socials as bonding exercises. The tone of the narratives depended on the context in which the events described occurred. Alcohol-related provocation occurs among some UK medical students and may present professionalism issues to medical students. Medical schools may wish to integrate more teaching

  7. The Teacher's Paradox

    Science.gov (United States)

    Lilyquist, J. Gary

    1998-06-01

    New findings suggest that the way in which schools conduct their business is blocking our educational system from improving at a rate required to meet society's needs. A ground theory developed by exploring six organizational dimensions: external and internal environment cultures, leadership, strategy, structure, and results, verified the existence of the teacher's paradox. Implications suggest educational reformers must rethink approaches to school improvement by work within cultural boundaries. The forth coming book, "Are schools really like this?" presents "The Balance Alignment Model and Theory" to improve our schools using system thinking.

  8. Paradox and pleasure

    DEFF Research Database (Denmark)

    Iversen, Sara Mosberg

    2014-01-01

    Media use is a mundane activity which may nevertheless be highly pleasurable. Here the focus is on the articulated pleasures of playing the digital games The Sims 2 and The Sims 3. The paradox that relief from everyday chores is found in a game which to a great degree simulates similar activities...... is analysed on the basis of 13 online or email qualitative interviews. The analysis employs the concepts of realism and fantasy which have been used to understand media pleasures as concerned both with the familiar and the utopic. While realism in some form or other appears important to most of the informants...

  9. Confronting Twin Paradox Acceleration

    Science.gov (United States)

    Murphy, Thomas W.

    2016-05-01

    The resolution to the classic twin paradox in special relativity rests on the asymmetry of acceleration. Yet most students are not exposed to a satisfactory analysis of what exactly happens during the acceleration phase that results in the nonaccelerated observer's more rapid aging. The simple treatment presented here offers both graphical and quantitative solutions to the problem, leading to the correct result that the acceleration-induced age gap is 2Lβ years when the one-way distance L is expressed in light-years and velocity β ≡v/c .

  10. The Scenario Planning Paradox

    DEFF Research Database (Denmark)

    Spaniol, Matthew Jon; Rowland, Nicholas James

    2017-01-01

    planning paradox. Contributing fresh theory supposedly attends to the “dismal” state of theory, while contributing new typologies purportedly helps bring order to methodological chaos. Repeated over time, the contribution strategy breaks down. Effort to resolve the theoretical and methodological issue......, foundational theoretical perspective in futures studies. Perceived chaos gives way to typologies, which, as they mount, contribute to the chaos they were meant to resolve. The end result, intended by no one, is that theory remains dismal and methods remain chaotic. This direction for the field is indefensible...

  11. Barn and Pole Paradox: Revisited

    Science.gov (United States)

    Cacioppo, Robert; Gangopadhyaya, Asim

    2012-01-01

    Paradoxes have played great instructive roles in many cultures. They provide an excellent paradigm for teaching concepts that require deep reflection. In this article, the authors present two different paradoxes related to the length contraction in special relativity and explain their resolution. They hope that these two Gedanken experiments and…

  12. Le paradoxe du linguiste

    Directory of Open Access Journals (Sweden)

    Primož Vitez

    2012-12-01

    Full Text Available Le linguiste, dans sa volonté explicite de s'imposer comme sujet scientifique et de décrire objectivement la langue comme un objet qui lui est extérieur, est paradoxal, parce que, du fait même qu'il est habité de sa langue, il se trouve nécessairement dans l'impossibilité de remplir la tâche qu'il se propose. Le paradoxe du linguiste consiste donc en cela que, si on se permet de paraphraser l'observation de Labov, « les faits de la langue s'étudient selon la vision de tel ou tel linguiste individuel, alors que le linguiste n'existe que par son expérience personnelle des faits linguistiques ». Cela signifie très simplement que le linguiste, en tant que descripteur d'une langue, n'est opératif qu'à l'intérieur de son objet d'analyse. La crédibilité de l'analyste dépend entièrement de la position éthique qu'il prendra vis-à-vis de sa recherche.

  13. The social dominance paradox.

    Science.gov (United States)

    Cook, Jennifer Louise; den Ouden, Hanneke E M; Heyes, Cecilia M; Cools, Roshan

    2014-12-01

    Dominant individuals report high levels of self-sufficiency, self-esteem, and authoritarianism. The lay stereotype suggests that such individuals ignore information from others, preferring to make their own choices. However, the nonhuman animal literature presents a conflicting view, suggesting that dominant individuals are avid social learners, whereas subordinates focus on learning from private experience. Whether dominant humans are best characterized by the lay stereotype or the animal view is currently unknown. Here, we present a "social dominance paradox": using self-report scales and computerized tasks, we demonstrate that socially dominant people explicitly value independence, but, paradoxically, in a complex decision-making task, they show an enhanced reliance (relative to subordinate individuals) on social learning. More specifically, socially dominant people employed a strategy of copying other agents when the agents' responses had a history of being correct. However, in humans, two subtypes of dominance have been identified: aggressive and social. Aggressively dominant individuals, who are as likely to "get their own way" as socially dominant individuals but who do so through the use of aggressive or Machiavellian tactics, did not use social information, even when it was beneficial to do so. This paper presents the first study of dominance and social learning in humans and challenges the lay stereotype in which all dominant individuals ignore others' views. The more subtle perspective we offer could have important implications for decision making in both the boardroom and the classroom. Copyright © 2014 Elsevier Ltd. All rights reserved.

  14. Paradoxical intention and recursive anxiety.

    Science.gov (United States)

    Ascher, L M; Schotte, D E

    1999-06-01

    The present study was designed to investigate a possible relationship between "recursive anxiety" and paradoxical intention. Groups of subjects were chosen from among individuals with public speaking concerns. and for whom fear of fear or recursive anxiety clearly represented an important element, or was completely absent from the clinical profile. These subjects were offered a standard in vivo treatment program for public speaking phobia with inclusion or exclusion of paradoxical intention. A 2 x 2 factorial design was employed. Those whose public speaking anxiety was complicated by recursive anxiety experienced greater improvement when paradoxical intention was included in the treatment program than when it was not employed. In contrast, individuals reporting simple public speaking phobia demonstrated greater success with a treatment program in which paradoxical intention was absent. Wegner's hypothesis of "ironic" cognitive processing was used to explain the proposed relationship between paradoxical intention and fear of fear.

  15. The Liar Paradox in Plato

    Directory of Open Access Journals (Sweden)

    Richard McDonough

    2015-06-01

    Full Text Available Although most scholars trace the Liar Paradox to Plato’s contemporary, Eubulides, the paper argues that Plato builds something very like the Liar Paradox into the very structure of his dialogues with significant consequences for understanding his views. After a preliminary exposition of the liar paradox it is argued that Plato builds this paradox into the formulation of many of his central doctrines, including the “Divided Line” and the “Allegory of the Cave” (both in the Republic and the “Ladder of Love” (in the Symposium. Thus, Plato may have been the first to formulate the view that Graham Priest calls dialetheism, roughly, the view that some contradictions are, in an illuminating way, inescapable and true. The paper argues that Plato builds this Liar paradox into the formulation of his signature views because he holds that the attempt by finite human beings to theorize about transcendent realities results in the simultaneous necessity, and impossibility, of transgressing the limits of language—leading to the paradoxes (contradictions. Finally, it is argued that the existence of these paradoxes in these Platonic doctrines is the direct result of an intrinsic hermeneutical circle in Plato’s aforementioned signature views.

  16. Paradoxes in aerohydrodynamics

    CERN Document Server

    Yershin, Shakhbaz A

    2017-01-01

    This book, on the general topic of hydroaerodynamics, investigates a number of exciting applications in this field, addressing specifically issues that allow seemingly paradoxical issues to be dealt with. The first part is devoted to the study of channel flows, in particular the lateral flow of a viscous and viscous-plastic liquid in a ring channel formed by coaxial cylinders. Specifically, the problem of dissipation of mechanical energy in channel flows of highly viscous liquids is addressed and solved. Furthermore, the mechanism leading to hydrodynamic erosion in intra-field pipelines (known as "channelized effect") is identified. Subsequently, a theory for channel flows with mass transfer through porous walls is developed. In the second part, viscous liquid free flows (jets) are investigated. In particular, a dispersion law for turbulent flow is derived and the existence of dynamic invariance in wake flows of variable density is demonstrated. The third part presents new insights from both theoretical and e...

  17. Plotting Gothic: A Paradox

    Directory of Open Access Journals (Sweden)

    Stephen Murray

    2014-06-01

    Full Text Available The paradox of the title is that while most historians of medieval architecture agree that a combination of geometric and arithmetic methods was generally used to lay out a medieval church, there has been little consensus on the specifics of the process in relation to the design of any particular edifice. I begin by identifying four premises which underlie the debate. I then ask whether the new technologies — laser scanning and computer assisted design/drafting applications — can help. A case study uses newly generated point cloud data from a laser scan of the choir of Beauvais Cathedral. Finally, the notion of ‘plotting’ introduces essential sociological, anthropological and rhetorical dimensions. In the spirit of Roland Barthes ('Le plaisir du texte' and Peter Brooks ('Reading for the Plot', we can understand the urgency with which the architectural historian may seek to unscramble the hidden codes of the building as compulsive ‘reading for the plot’.

  18. Mimesis, fiction, paradoxes

    Directory of Open Access Journals (Sweden)

    Françoise Lavocat

    2010-04-01

    Full Text Available Les théories contemporaines de la fiction, comme les poétiques de la Renaissance, privilégient une conception de la mimesis fondée sur la vraisemblance : la démonstration du profit cognitif et moral de la fiction passe toujours par une définition de l’imitation (de quelque façon qu’on la définisse fondée sur la rationalité. L’auteur de cet article examine tout d’abord le statut des contradictions et de l’impossible chez quelques théoriciens actuels (principalement J.-M. Schaeffer, M.-L. Ryan, L. Doležel et poéticiens du 16e siècle (L. Castelvetro et F. Patrizi. Sont ensuite étudiées la forme et la fonction que prend l’impossible dans trois fictions narratives de la Renaissance. L’hypothèse majeure qui est défendue est que ces paradoxes permettent de penser le non-existant, dans la continuité de la scolastique médiévale et en relation avec une problématique religieuse, sérieuse ou parodique. Par là même, et en raison de leur auto-référentialité constitutive, les paradoxes inscrivent dans la fiction une réflexion sur elle-même qui n’a rien d’une apologie. La pensée de la fiction s’articule en définitive de façon bien différente dans les théories et dans les fictions elles-mêmes.Like Renaissance poetics, contemporary theories of fiction do favour a conception of mimesis based on likelihood. In order to underscore the benefits of fiction, in terms of cognition or ethics, both ancient and present-day authors usually identify imitation (however this is understood as a kind of rationality. The aim of this article is to question the status of contradictions and impossibilities, first in current theories of fiction (J-M Schaeffer, M.-L. Ryan, L. Doležel, then in two sixteenth century comments of Aristotle (by L. Castelvetro and F. Patrizi. In the following steps, forms and functions of the impossible are studied in three narratives of the Renaissance. The main hypothesis here is the following: in

  19. Euthanasia: the final paradox.

    Science.gov (United States)

    Ellard, John

    2007-10-01

    The aim of this paper is to consider the history of human beings killing one another and reflect upon their reasons. Has it ever been altruistic? Important examples of large episodes of killing, such as wars, the Crusades, the Inquisition and genocides were examined. Reasons are always advanced for killing large numbers of people who did not want to die. They were not based on logic nor on altruism but on moralities constructed from religious and political beliefs. Those who wanted to die because of unrelievable pain involved in the process of dying from an incurable illness are always preserved against their wishes. Once more, the reasons were usually religious and/or politically supported. The belief that it is acceptable to kill those who do not want to die but unacceptable to kill those who want to die provides a curious paradox.

  20. Paradoxes of participation

    DEFF Research Database (Denmark)

    Lund, Jens Friis

    2015-01-01

    Processes of participatory forestry reform in the Global South in recent decades present us with a paradox. While ostensibly aimed at promoting participation by forest adjacent communities, these reforms more often appear to sustain domination by forest administrations or private enterprises...... and have increasingly been associated with inequitable social outcomes. Part of the explanation for this must be sought in the professionalization promoted by these reforms in the sense of scientific management approaches and structured and detailed systems of information gathering, dissemination...... and procedurally demanding framings that inhibit implementation, downplay politics and promote inequality. The contributions to this special issue illustrate empirical pathways to unpack and question the framing of participatory forestry as professionalization by pointing to its anti-democratic and social...

  1. The Paradox of Openness

    DEFF Research Database (Denmark)

    Laursen, Keld; Salter, Ammon

    2014-01-01

    often requires openness, but the commercialization of innovations requires protection. Based on econometric analysis of data from a UK innovation survey, we find a concave relationship between firms’ breadth of external search and formal collaboration for innovation, and the strength of the firms......To innovate, firms often need to draw from, and collaborate with, a large number of actors from outside their organization. At the same time, firms need also to be focused on capturing the returns from their innovative ideas. This gives rise to a paradox of openness—the creation of innovations...... or collaborate with competitors. We explore the implications of these findings for the literature on open innovation and innovation strategy....

  2. Indirect bronchial provocation tests in childhood asthma : Monitoring short-term treatment changes

    NARCIS (Netherlands)

    Kersten, Elin

    2015-01-01

    In this thesis, we used indirect bronchial provocation tests to monitor treatment changes in asthmatic children. Indirect bronchial provocation tests assess the response of the airways to stimuli that act on inflammatory cells present in the airways. The response to indirect stimuli is greater in

  3. The paradoxical path towards the memorable guest experience

    DEFF Research Database (Denmark)

    d'Ambrosio, Luigi; Madsen, Jan Halberg

    This paper examines the design of hospitality and tourism experiences staged for international tourists in the emerging Italian destination Campi Flegrei on the Bay of Naples. In particular, this case focuses on the paradox that Campi Flegrei (CF) hospitality providers around the Lake Avernus fac...... in the conceptualisation of the guest experience in the context of a non-DMO governed destination....

  4. A study of drug eruptions by provocative tests

    Directory of Open Access Journals (Sweden)

    Das J

    2001-09-01

    Full Text Available Sixty cases of drug eruptions were observed during the period of one year. The incidence of drug eruption was 0.47% amongst all Dermatology O.P.D. attendances. Male to female ratio was 7:3. The highest number of cases were seen in the age group of 21-30 years. Fixed drug eruptions were the most frequent (58.3%, followed by urticaria and angioedema (20%. The drug sulphonamides (including co-trimoxazole accounted for the highest number of eruptions (35%. The other drugs which were responsible for the eruptions, in order of frequency, were oxyphenbutazone, ampicillin, analgin, penicillin, tetracycline, ibuprofen, paracetamol, phenylbutazone, acetaminophen and phenobarbitone. The causative drug (s were confirmed by provocation tests in 42 (70% cases.

  5. Fantaisies et paradoxes mathématiques

    CERN Document Server

    Northrop, E P

    1964-01-01

    Qu'est-ce qu'un paradoxe ? ; quelques casse-tête simples (paradoxes pour tous) ; le puissant petit 2 et autres miracles... (paradoxes en arithmétique) ; je le vois, je ne le vois plus... (paradoxes en géométrie) ; tu ne diviseras pas par zéro... (sophismes algébriques) ; le voir, c'est le croire. Peut-être... (sophismes géométriques) ; toujours plus loin... (paradoxes de l'infini) ; combien de chances ? (paradoxes en probabilité) ; cercles vicieux (paradoxes en logique).

  6. KM PARADOX ON CITY MANAGEMENT

    OpenAIRE

    Sebastian-Ion CEPTUREANU; Eduard-Gabriel CEPTUREANU

    2012-01-01

    This paper presents some thoughts about a relative paradox of knowledge management: both a well established area of science and one of the managerial science domains still under scrutiny for several important inconsistencies and misunderstandings.

  7. Altruism and the Transfer Paradox

    OpenAIRE

    Hamada, Kojun

    2011-01-01

    This paper examines whether altruism causes the transfer paradox in the model with two countries and two goods when the consumers of the donor and recipient countries have altruistic utility. We demonstrate that if the Walrasian stability condition is satisfied in the general equilibrium, the transfer paradox can never take place irrespective of the definition of utility. The result suggests that the motivation for transfer cannot beexplained by the donor's enrichment because it is not caused...

  8. Paradoxical therapy in conversion disorder

    OpenAIRE

    ATAOĞLU, Ahmet

    2014-01-01

    Paradoxical therapy consists of suggesting that the patient intentionally engages in the unwanted behaviour, such as performing complusive ritual or bringing on a conversion attack. In this study paradoxical intention (PI) was used with to half of the patients with conversion disorders, while the other half were treated with diazepam in order to examine the efficiency of the PI versus diazepam in conversion disorder. Patients treated with PI appeared to have a greater improvement r...

  9. Sleep Education for Paradoxical Insomnia

    OpenAIRE

    Geyer, James D.; Lichstein, Kenneth L.; Ruiter, Megan E.; Ward, L. Charles; Paul R. Carney; Dillard, Stephenie C.

    2011-01-01

    This case study series investigated a new treatment for paradoxical insomnia patients as there is no standard treatment for this patient group at this time. Four paradoxical insomnia patients had a polysomnography (PSG) sleep study, an unsuccessful brief course of behavioral treatment for insomnia, and then a novel sleep education treatment comprising review of their PSG with video and exploration of the discrepancy between their reported and observed sleep experience. Two patients responded ...

  10. The obesity paradox: is it really a paradox? Hypertension.

    Science.gov (United States)

    Lechi, Alessandro

    2017-03-01

    This article is a narrative overview of the role of hypertension on the relationships between obesity, morbidity, and mortality. We used as sources MEDLINE/PubMed, CINAHL, EMBASE, and Cochrane Library, from inception to March 2016. Key words include overweight, obesity, visceral obesity, obesity paradox, and hypertension. In addition, we hand-searched references from the retrieved articles. This work is one of the works of the topical collection "Obesity Paradox". The positive association between overweight, obesity, and cardiovascular diseases is well established, though this relation is typically U shaped with an increased risk in low-weight subjects or even a beneficial effect of overweight and obesity, the so-called "obesity paradox". In addition, the relationship between obesity and arterial hypertension has been demonstrated in both children and adults by many epidemiological studies. Moreover, weight reduction is followed by a decrease in blood pressure in many patients and ameliorates the cardiovascular risk profile. Recent studies using more appropriate obesity indices raise some doubt about the real significance of obesity paradox and there are several studies that central obesity shows either no protective or even a worse effect. These observations raise the question: what kind of obesity is protective and what kind of obesity is harmful? The studies of obesity paradox suffer from several methodological limitations: most of these are retrospective analyses or were not specifically designed to study obesity paradox as a primary goal; a few studies have data on preceding unintentional weight loss and on some particular confounding variables. In conclusion, more prospective and accurate studies are necessary to better elucidate the clinical importance of obesity paradox. When weight loss is functional to reduce hypertension and cardiovascular risk, it should be encouraged, while an unintentional weight in a patient with chronic diseases may indicate an

  11. Obesity and the obesity paradox in heart failure.

    Science.gov (United States)

    Clark, Adrienne L; Fonarow, Gregg C; Horwich, Tamara B

    2014-01-01

    Obesity is a growing public health problem in the general population, and significantly increases the risk for the development of new-onset heart failure (HF). However, in the setting of chronic HF, overweight and mild to moderate obesity is associated with substantially improved survival compared to normal-weight patients. Evidence exists for an "obesity paradox" in HF, with the majority of data measuring obesity by body mass index, but also across various less-frequently used measures of body fat (BF) and body composition including waist circumference, waist-hip ratio, skinfold estimates of percent BF, and bioelectrical impedance analysis of body composition. Other emerging areas of investigation such as the relationship of the obesity paradox to cardiorespiratory fitness are also discussed. Finally, this review explores various explanations for the obesity paradox, and summarizes the current evidence for intentional weight loss treatments for HF in context. © 2014.

  12. A relativistic trolley paradox

    Science.gov (United States)

    Matvejev, Vadim N.; Matvejev, Oleg V.; Grøn, Ø.

    2016-06-01

    We present an apparent paradox within the special theory of relativity, involving a trolley with relativistic velocity and its rolling wheels. Two solutions are given, both making clear the physical reality of the Lorentz contraction, and that the distance on the rails between each time a specific point on the rim touches the rail is not equal to 2 π R , where R is the radius of the wheel, but 2 π R / √{ 1 - R 2 Ω 2 / c 2 } , where Ω is the angular velocity of the wheels. In one solution, the wheel radius is constant as the velocity of the trolley increases, and in the other the wheels contract in the radial direction. We also explain two surprising facts. First that the shape of a rolling wheel is elliptical in spite of the fact that the upper part of the wheel moves faster than the lower part, and thus is more Lorentz contracted, and second that a Lorentz contracted wheel with relativistic velocity rolls out a larger distance between two successive touches of a point of the wheel on the rails than the length of a circle with the same radius as the wheels.

  13. Paradoxes of Visibility

    Directory of Open Access Journals (Sweden)

    Tarnay László

    2017-12-01

    Full Text Available The paper investigates two possible critical arguments following the pictorial turn. The first is formulated within ocularcentrism, the dominance of sight, and starts with the right to visibility as a general principle that governs today’s digital culture but gets twisted in special cases like the Auschwitz photos of the Shoa, the Abu Ghraib prison videos, or recently the website called Yolocaust. The second is conceived outside the visual culture and is meant to vindicate the other senses vis-à-vis the eyes. However, the argument is truncated here only to highlight the boomerang effect of the other senses: haptic vision. It is the case of visual perception when (a there is a lack of things to see and (b indeterminate synaesthesia: when vision intensifies the other senses in the embodied viewer. The two arguments converge upon a dialectic of the visible and the imaginable, which is formulated here as two paradoxes that the discussed examples transcend. By enforcing visibility at all costs where there is hardly anything recognizable to see, they lead to two diverging results. On the one hand, the meaning of “image” is extended toward the unimaginable, the traumatic experience, on the other hand, it is extended toward the invisible, the encounter with the radical Other.

  14. Paradoxes, puzzles and passing time.

    Science.gov (United States)

    Rankin-Box, D

    1999-12-01

    Whilst technology and our understanding about the world has improved, I suspect that in many ways, the hopes, fears, worries, joy and love we feel are not so different from that of our ancestors of 500 or 700 years ago, though the social circumstances may have altered. We have beliefs and dreams and daily routines in our lives and many people hang onto age old superstitions without really knowing their origins, e.g. crossing our fingers for luck, touching wood, throwing salt over a shoulder or reading about star signs. The night sky also looks different to 1000 years ago. When we look up at the stars we see an image of the past in the present: the light we see set off from its origin long before the advent of antibiotics, the Russian Revolution or the first man on the moon. As we move forwards, the benefits of modern medicine and improvements in social and environmental issues (compared to just 100 years ago) have, paradoxically, provided us with a quality of life that allows us to live longer and gain a greater insight into the world around us. There is an opportunity to reflect and wonder at the healers of the early middle ages and of the way in which we wish medicine to develop. When reflecting about the past 1000 years, patterns begin to emerge of times past, epochs of healing and revolutions in the way we perceive myriad aspects of health and healing. I am sure there are ways of combining ancient ways with modern thinking, of blending art and science, of balancing logic and rationality with love, fun, humour and empathy. Of building on experience, so that caring is spiritually therapeutic, freeing our patients and ourselves as we move into the future and the new millennium.

  15. Paradoxes and Innovation in Family Firms

    DEFF Research Database (Denmark)

    Ingram, Amy E.; Lewis, Marianne W.; Barton, Sid

    2016-01-01

    Scholars stress that family firms are inherently paradoxical, and that tensions, such as tradition versus change, family liquidity versus business growth, and founder control versus successor autonomy, can both inhibit and foster innovation. Further, theorists propose that firms led by paradoxica...... indicate that paradoxical tensions may stymie innovative behavior, but that leaders' paradoxical thinking is positively related to innovative behavior....... thinkers are more likely to manage these tensions and fuel innovative behavior. Leveraging family business and organizational paradox literatures, this multi-stage exploratory study develops measures of paradoxical tensions and paradoxical thinking in family firms, and tests these propositions. Findings...

  16. EMG and cardiovascular responses to emotionally provocative photographs and text.

    Science.gov (United States)

    Livesay, J R; Porter, T

    1994-08-01

    Previous studies on the psychophysiology of human emotion have repeatedly shown general and occasionally specific facial EMG (mu v) and covert cardiovascular response relationships to emotionally provocative photographs. Less clear are the relationships between psychophysiological response indices measured during the silent reading of emotionally charged versus emotionally neutral text. In this study, 12 adult subjects were presented two emotionally loaded color and black-and-white photographs and two brief newspaper articles, one emotionally charged and the other emotionally neutral in content. Each independent stimulus was presented for 1 min., preceded by a rest according to a multiple baseline-reversal design. Subjects evaluated each pictorial and textual stimulus condition according to adjective dimensions on 7-point rating scales. Mean values for corrugator supercilii EMG (mu v), upper trapezius EMG (mu v), surface temperature (degrees F), and heart rate (bpm) measured by finger photoplethysmography were measured during each rest and test period. Significant increases in the subjects' mean corrugator supercilii EMG (mu v) measures were observed during all color and black-and-white photograph presentations for both emotional and neutral content. As predicted, the subjects' mean corrugator supercilii EMG (mu v) measures increased significantly while silently reading text with an obvious unpleasant emotional tone. A significant positive relationship was observed between the subjects' mean ratings and mean corrugator EMG (mu v) difference values for the emotionally loaded color photographs.

  17. Psychobiological characteristics of dissociative identity disorder: a symptom provocation study.

    Science.gov (United States)

    Reinders, A A T Simone; Nijenhuis, Ellert R S; Quak, Jacqueline; Korf, Jakob; Haaksma, Jaap; Paans, Anne M J; Willemsen, Antoon T M; den Boer, Johan A

    2006-10-01

    Dissociative identity disorder (DID) patients function as two or more identities or dissociative identity states (DIS), categorized as 'neutral identity states' (NIS) and 'traumatic identity states' (TIS). NIS inhibit access to traumatic memories thereby enabling daily life functioning. TIS have access and responses to these memories. We tested whether these DIS show different psychobiological reactions to trauma-related memory. A symptom provocation paradigm with 11 DID patients was used in a two-by-two factorial design setting. Both NIS and TIS were exposed to a neutral and a trauma-related memory script. Three psychobiological parameters were tested: subjective ratings (emotional and sensori-motor), cardiovascular responses (heart rate, blood pressure, heart rate variability) and regional cerebral blood flow as determined with H(2)(15)O positron emission tomography. Psychobiological differences were found for the different DIS. Subjective and cardiovascular reactions revealed significant main and interactions effects. Regional cerebral blood flow data revealed different neural networks to be associated with different processing of the neutral and trauma-related memory script by NIS and TIS. Patients with DID encompass at least two different DIS. These identities involve different subjective reactions, cardiovascular responses and cerebral activation patterns to a trauma-related memory script.

  18. Four paradoxes about the special theory of relativity

    OpenAIRE

    Li, Xiao-Jun; Chen, Kai; Li, Xiao-Niu; Li, Yong-An

    2016-01-01

    Various paradoxes about the relativity theory have been developed since the birth of this theory. Each paradox somewhat shows people's query about the relativity theory, and solving of each paradox demonstrates the correctness of relativity theory once again. In this paper, four paradoxes about the special theory of relativity are brought forward: displacement paradox, electromagnetic transformation paradox, Doppler paradox and magnetic force paradox. We hope some researchers can reasonably e...

  19. North Korea's choice of the types of provocation against South Korea

    OpenAIRE

    Lee, Hyun Haeng

    2013-01-01

    Approved for public release; distribution is unlimited. This research starts from the question of how North Korea decides upon the types of its provocations against the South. To find the answer, the author divides the major provocations into three periods, according to their characteristics, and examines how the major decisive factors of the Norths crisis policy making, such as military strength, relations with China and the Soviet Union (Russia), regime stability, and economic power, aff...

  20. The paradox of scientific expertise

    DEFF Research Database (Denmark)

    Alrøe, Hugo Fjelsted; Noe, Egon

    2011-01-01

    Modern societies depend on a growing production of scientific knowledge, which is based on the functional differentiation of science into still more specialised scientific disciplines and subdisciplines. This is the basis for the paradox of scientific expertise: The growth of science leads...... cross-disciplinary research and in the collective use of different kinds of scientific expertise, and thereby make society better able to solve complex, real-world problems....... to a fragmentation of scientific expertise. To resolve this paradox, the present paper investigates three hypotheses: 1) All scientific knowledge is perspectival. 2) The perspectival structure of science leads to specific forms of knowledge asymmetries. 3) Such perspectival knowledge asymmetries must be handled...

  1. Painful and provocative events scale and fearlessness about death among Veterans: Exploratory factor analysis.

    Science.gov (United States)

    Poindexter, Erin K; Nazem, Sarra; Forster, Jeri E

    2017-01-15

    The interpersonal theory of suicide suggests three proximal risk factors for suicide: perceived burdensomeness, thwarted belongingness, and acquired capability. Previous literature indicates that repetitive exposure to painful and provocative events is related to increased acquired capability for suicide. Despite this, research related to the assessment of painful and provocative events has been insufficient. Research has inconsistently administered the Painful and Provocative Events Scale (PPES; a painful and provocative events assessment), and no study has examined the factor structure of the English PPES. This study explored the factor structure of the PPES and the relation between factors and fearlessness about death. The sample was a cross-sectional, self-report study comprised of 119 Veterans (Mage = 46.5, SD = 13.5). Findings from an exploratory factor analysis indicated a four-factor solution for the PPES; however, no factor from the PPES significantly related to fearlessness about death (measured by the Acquired Capability for Suicide Scale - Fearlessness About Death Scale; all p >.21). Cross-sectional, small Veteran sample. Findings suggest that the PPES lacks the psychometric properties necessary to reliably investigate painful and provocative factors. Consequently, this measure may not reliably capture and explain how painful and provocative events relate to fearlessness about death, which is a barrier to improving suicide risk assessment and prediction. Recommendations for the construction of a new PPES are offered. Published by Elsevier B.V.

  2. The effects of a provocation on aggression for three types of alcohol users.

    Science.gov (United States)

    Baldwin, J J; Randolph, D L

    1982-04-01

    Investigated the effects of a provocation on aggression for three types of alcohol users. The Alcohol Use Inventory was used to select 30 light-moderate and 30 moderate drinkers. Thirty abstainers were selected as a control group. Half of each group was assigned randomly to one of two treatments, a provocation or a no-provocation. After treatment, each S completed the Adjective Rating Form (ARF) verbal aggression scales and the Multiple Affect Adjective Checklist (MAACL). The results of this study indicated that, for both instruments, the provocation elicited significantly more feelings of hostility and verbal aggression than the no-provocation. However, there were no significant level effects, nor was there a significant interaction between level of drinking and presence of a provocation. The failure to find significant level effects was attributed to the abstainers' scores. With the abstainer category excluded from the analysis, additional findings resulted in significant level effects for the MAACL hostility scales, but not for the ARF verbal aggression scales. It was recommended that future studies investigate risk factors of abstinence and eliminate the abstainer category as a control.

  3. Teaching Quantum Physics without Paradoxes

    Science.gov (United States)

    Hobson, Art

    2007-01-01

    Although the resolution to the wave-particle paradox has been known for 80 years, it is seldom presented. Briefly, the resolution is that material particles and photons are the quanta of extended spatially continuous but energetically quantized fields. But because the resolution resides in quantum field theory and is not usually spelled out in…

  4. The Paradox of Modern Suffering

    DEFF Research Database (Denmark)

    Dræby, Anders

    The Paradox of Suffering in modern western Culture In non-western cultures and pre-modern western cultures suffering is considered the normal state of life. Corrispondingly the suffering of oneself and that of other people form a central focus to most religions, their practices and philosophies. ...... one is to achieve salvation in an existence after death....

  5. Mechanical Paradox: The Uphill Roller

    Science.gov (United States)

    Cortes, Emilio; Cortes-Poza, D.

    2011-01-01

    We analyse in detail the dynamics of a mechanical system which is a rigid body with the geometry of a double cone. This double cone is apparently able to spontaneously roll uphill along inclined rails. The experiment has been known for some centuries, and because of its peculiar behaviour, it has been named "mechanical paradox". Although this…

  6. Paradoxical effect after IPL photoepilation.

    Science.gov (United States)

    Moreno-Arias, Gerardo; Castelo-Branco, Camil; Ferrando, Juan

    2002-11-01

    Intense pulsed light (IPL) is an effective and safe hair removal method. However, it is not exempt from side effects. To evaluate clinical and hormonal characteristics of females with facial hirsutism that developed hair growth in untreated areas close to the area submitted to IPL photoepilation ("paradoxical effect"). A total of 49 females with facial hirsutism were included in a protocol of photoepilation with an IPL source. Hyperandrogenism of tumoral origin was excluded in all subjects. Serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), prolactin (PRL), testosterone (T), androstenedione (A), dehydroepiandrosterone sulfate (DHEAS), 17-OH-progesterone (OHP), and sex hormone binding globulin (SHBG) were determined prior to IPL treatment. Clinical and photographic evaluation was performed immediately before each treatment session and 2, 6, and 9 months after the last treatment session. Only cases with "paradoxical effect" were included in this study. A total of five patients with "paradoxical effect" were identified. The patients' ranged in age from 13 to 44 years and all of them had skin phototype III (Fitzpatrick scale). All these subjects were diagnosed with polycystic ovarian syndrome and presented ovarian hyperandrogenism. Patients underwent six to nine IPL sessions, and "paradoxical effect" appeared at different times during the protocol, between treatment session 3 and 6 months after the conclusion of treatment. IPL may induce activation of dormant hair follicles in untreated areas close to hirsute-treated areas.

  7. The Banach-Tarski paradox

    CERN Document Server

    Wagon, Stan

    1985-01-01

    The Banach-Tarski paradox is a most striking mathematical construction: it asserts that a solid ball may be taken apart into finitely many pieces that can be rearranged using rigid motions to form a ball twice as large as the original. This volume explore

  8. Acute coronary syndrome of paradoxical origin.

    Science.gov (United States)

    Ferreira, Ana Rita; Freitas, António; Magno, Pedro; Soares, Ana Oliveira; Farto e Abreu, Pedro; Neves, José Pedro; Gil, Victor M

    2013-10-01

    We describe a rare case of acute myocardial infarction secondary to paradoxical embolism complicating acute pulmonary embolism. A 44-year-old woman presented to the emergency department with chest pain. The physical examination was unremarkable except for oxygen saturation of 75%, and the electrocardiogram showed ST-segment elevation in the inferior leads. Urgent coronary angiography showed a distal occlusion of the right coronary artery and multiple thrombi were aspirated. Despite relief of chest pain and electrocardiogram normalization, her oxygen saturation remained low (90%) with high-flow oxygen by mask. The transthoracic echocardiogram showed a mass in the left atrium and dilatation of the right chambers, while the transesophageal echocardiogram showed a thrombus attached to the interatrial septum in the region of the foramen ovale. Color flow imaging was consistent with a patent foramen ovale. Thoracic computed tomography angiography documented thrombi in both branches of the pulmonary trunk. After five days on anticoagulation, the patient underwent surgical foramen ovale closure.

  9. Evaluation of a provocative dyspnea severity score in acute heart failure.

    Science.gov (United States)

    AbouEzzeddine, Omar F; Lala, Anuradha; Khazanie, Prateeti P; Shah, Ravi; Ho, Jennifer E; Chen, Horng H; Pang, Peter S; McNulty, Steven E; Anstrom, Kevin J; Hernandez, Adrian F; Redfield, Margaret M

    2016-02-01

    The acute heart failure (AHF) Syndromes International Working Group proposed that dyspnea be assessed under standardized, incrementally provocative maneuvers and called for studies to assess the feasibility of this approach. We sought to assess the feasibility and statistical characteristics of a novel provocative dyspnea severity score (pDS) versus the traditional dyspnea visual analog scale (DVAS) in an AHF trial. At enrollment, 24, 48 and 72hours, 230 ROSE-AHF patients completed a DVAS. Dyspnea was then assessed with 5-point Likert dyspnea scales administered during 4 stages (A: upright-with O2, B: upright-without O2, C: supine-without O2 and D: exercise-without O2). Patients with moderate or less dyspnea were eligible for the next stage. At enrollment, oxygen withdrawal and supine provocation were highly feasible (≥97%), provoking more severe dyspnea (≥1 Likert point) in 24% and 42% of eligible patients, respectively. Exercise provocation had low feasibility with 38% of eligible patients unable to exercise due to factors other than dyspnea. A pDS was constructed from Likert scales during the 3 feasible assessment conditions (A-C). Relative to DVAS, the distribution of the pDS was more skewed with a high "ceiling effect" at enrollment (23%) limiting sensitivity to change. Change in pDS was not related to decongestion or 60-day outcomes. Although oxygen withdrawal and supine provocation are feasible and elicit more severe dyspnea, exercise provocation had unacceptable feasibility in this AHF cohort. The statistical characteristics of a pDS based on feasible provocation measures do not support its potential as a robust dyspnea assessment tool in AHF. Copyright © 2015 Elsevier Inc. All rights reserved.

  10. Provocation of symmetry/ordering symptoms in Anorexia nervosa: a functional neuroimaging study.

    Directory of Open Access Journals (Sweden)

    Masashi Suda

    Full Text Available Anorexia nervosa (AN, obsessive-compulsive disorder (OCD, and obsessive-compulsive personality disorder (OCPD are often co-morbid; however, the aetiology of such co-morbidity has not been well investigated. This study examined brain activation in women with AN and in healthy control (HC women during the provocation of symmetry/ordering-related anxiety. During provocation, patients with AN showed more anxiety compared to HCs, which was correlated with the severity of symmetry/ordering symptoms. Activation in the right parietal lobe and right prefrontal cortex (rPFC in response to provocation was reduced in the AN group compared with the HC group. The reduced right parietal activation observed in the AN group is consistent with parietal lobe involvement in visuospatial cognition and with studies of OCD reporting an association between structural abnormalities in this region and the severity of 'ordering' symptoms. Reduced rPFC activation in response to symmetry/ordering provocation has similarities with some, but not all, data collected from patients with AN who were exposed to images of food and bodies. Furthermore, the combination of data from the AN and HC groups showed that rPFC activation during symptom provocation was inversely correlated with the severity of symmetry/ordering symptoms. These data suggest that individuals with AN have a diminished ability to cognitively deal with illness-associated symptoms of provocation. Furthermore, our data also suggest that symptom provocation can progressively overload attempts by the rPFC to exert cognitive control. These findings are discussed in the context of the current neurobiological models of AN.

  11. Relativistic Paradoxes and Lack of Relativity in Closed Spaces

    CERN Document Server

    Fayngold, Moses

    2015-01-01

    Some known relativistic paradoxes are reconsidered for closed spaces, using a simple geometric model. For two twins in a closed space, a real paradox seems to emerge when the traveling twin is moving uniformly along a geodesic and returns to the starting point without turning back. Accordingly, the reference frames (RF) of both twins seem to be equivalent, which makes the twin paradox irresolvable: each twin can claim to be at rest and therefore to have aged more than the partner upon their reunion. In reality, the paradox has the resolution in this case as well. Apart from distinction between the two RF with respect to actual forces in play, they can be distinguished by clock synchronization. A closed space singles out a truly stationary RF with single-valued global time; in all other frames, time is not a single-valued parameter. This implies that even uniform motion along a spatial geodesic in a compact space is not truly inertial, and there is an effective force on an object in such motion. Therefore, the...

  12. The Fermi Paradox is Neither Fermis Nor a Paradox

    CERN Document Server

    Gray, Robert H

    2016-01-01

    The so-called Fermi paradox claims that if technological life existed anywhere else, we would see evidence of its visits to Earth-and since we do not, such life does not exist, or some special explanation is needed. Enrico Fermi, however, never published anything on this topic. On the one occasion he is known to have mentioned it, he asked 'where is everybody?'- apparently suggesting that we don't see extraterrestrials on Earth because interstellar travel may not be feasible, but not suggesting that intelligent extraterrestrial life does not exist, or suggesting its absence is paradoxical. The claim 'they are not here; therefore they do not exist' was first published by Michael Hart, claiming that interstellar travel and colonization of the galaxy would be inevitable if intelligent extraterrestrial life existed, and taking its absence here as proof that it does not exist anywhere. The Fermi paradox appears to originate in Hart's argument, not Fermi's question. Clarifying the origin of these ideas is important...

  13. Posterior pelvic pain provocation test is negative in patients with lumbar herniated discs.

    Science.gov (United States)

    Gutke, Annelie; Hansson, Eva Roos; Zetherström, Gunilla; Ostgaard, Hans Christian

    2009-07-01

    The classification of pelvic girdle pain can only be reached after lumbar causes have been excluded by a clinical examination. During clinical examination, the posterior pelvic pain provocation test is a well-established method for verifying pelvic girdle pain. However, a criticism of pelvic pain provocation tests is that they may have an effect on lumbar structures, thus yielding false-positive results. The posterior pelvic pain provocation test was performed with four groups of patients: patients with computed tomography-verified disc herniations (1) on the waiting list for surgery (14 women; 9 men); (2) 6 weeks after disc surgery (18 women, 12 men); (3) pregnant women seeking care for pelvic girdle pain (n = 25); and (4) women with persistent pelvic girdle pain after delivery (n = 32). The sensitivity of the posterior pelvic pain provocation test was 0.88 and the specificity was 0.89. The positive predictive value was 0.89 and the negative predictive value was 0.87. Analysis of only women showed similar results. In our study, the posterior pelvic pain provocation test was negative in patients with a well-defined lumbar diagnosis of lumbar disc herniation, both before and after disc surgery. Our results are an important step toward the more accurate classification of lumbopelvic pain.

  14. Systemic provocation in doxycycline induced fixed drug eruption: a case report

    Directory of Open Access Journals (Sweden)

    Anik Murwaningsih Rosmarini Estri Sih Hananti Niken Indrastuti

    2014-04-01

    Full Text Available Fixed drug eruption (FDE is recurrent lesions that upon repeated uptake of causative drug, always appears at the same skin and mucosal site. Determination of causal relationship in drug allergy is very important. In this case report, cases of doxycycline-induced FDE was reported. The subject of the research was a 29-year-old male, referred by dermatologist, with history of reccurent FDE. Physical examination revealed an oval well demarcated patch hyperpigmentation. Patch test was perfomed on previous involved and uninvolved site. The result of the patch test was irrelevant. Retesting patch test gave similar result. Systemic provocation test or drug provocation test (DPT  with doxcycline were done with suspected drug under ambulatory survelance and gave positive result. In this case, the DPT succeeded to identify doxycycline as the causal agent of FDE. The work-up of a suspected drug hypersensitivity includes a detailed clinical history, physical examination, skin tests, and provocation tests. The DPT is recommended to confirm drug’s hypersensitivity reactions. Systemic provocation test is considered as the gold standard for diagnosing FDE. Keywords:   fixed drug eruption - doxycycline - causal relationship - patch test - systemic provocation test

  15. COMMUNICATIVE PROVOCATION AS A STRATEGY OF DESTRUCTIVE BEHAVIOUR IN EVERY-DAY CONFLICT

    Directory of Open Access Journals (Sweden)

    Volkova Olga Sergeevna

    2014-12-01

    Full Text Available The article is concentrated on the issue of systematization and classification of strategies and tactics of individual's verbal behavior in a number of typical situations associated with disharmonious communication. Its scientific originality is defined by the necessity to present the provocation phenomenon as a category of communicative linguistics and linguistic pragmatics. The use of discourse analysis and descriptive pragmatic interpretation of real communication forms have enabled the revelation of various patterns of destructive verbal behavior that could provoke a communicative conflict. Communicative provocation is described as a strategy of destructive behavior aimed at dragging a communication partner into a conflict interaction or creating conditions for its occurrence. The provocation strategy is implemented in disharmonious interactions by means of individual or complex communication tactics including not only the aggressive ones: indignation, reproach, deliberate false informing, exaggerated demonstration of emotions, but also such tolerant tactics as praise, advice, apology, assurances, admiration, persuasion, etc. Two forms of communicative provocation are represented in the article. A direct provocation presupposes personal involvement of a provocateur in the conflict interaction while an indirect one allows its initiator stay aside from the open confrontation. In the latter case the provocateur stimulates and demonstrates the parties' conflict of interests, which leads to the communication harmony disruption.

  16. Peran Media Relations terhadap Keberhasilan Program Provocative Proactive di Pt Media Televisi Indonesia (Metro Tv

    Directory of Open Access Journals (Sweden)

    Marta Sanjaya

    2013-10-01

    Full Text Available This article aims to determine whether the Provocative Proactive (PP program on Metro TV proactive is known by Indonesian people, to explain how the media selection strategy for Provocative Proactive program is, and to explain the program on Metro TV can be written and known by the press or reporters (external PR. The method used was descriptive qualitative approach to analyze the existing problems by presentation of information from the data collected through the company's internal analysis of the results of in-depth interviews and field observations regarding activities in the company. The results showed that duties and functions of public relations are as a motor for better co-operation with external and internal parties relating to Provocative Proactive program. The PR and Promotion Departments were turned out to help the success of the PP program, in addition to various roles and hardworks of the Producer and the creative team. Based on the observations, the role of Metro TV’s PR and Promotion Departments in conducting media relations through cooperation with the media both print and electronic media in an effort to have Provocative Proactive widely known by the public is through cooperation with various mass media, implementation of mass media selection strategies, and introducing Provocative Proactive Program broadly.  

  17. Quantum Phase from the Twin Paradox

    Science.gov (United States)

    Ord, G. N.

    2012-05-01

    The modern concept of spacetime usually emerges from the consideration of moving clocks on the assumption that world-lines are continuous. In this paper we start with the assumption that natural clocks are digital and that events are discrete. By taking different continuum limits we show that the phase of non-relativistic quantum mechanics and the odd metric of spacetime both emerge from the consideration of discrete clocks in relative motion. From this perspective, the continuum limit that manifests itself in 'spacetime' is an infinite mass limit. The continuum limit that gives rise to the Schrödinger equation retains a finite mass as a beat frequency superimposed on the 'Zitterbewegung' at the Compton frequency. We illustrate this in a simple model in which a Poisson process drives a relativistic clock that gives rise to a Feynman path integral, where the phase is a manifestation of the twin paradox. The example shows that the non-Euclidean character of spacetime and the wave-particle duality of quantum mechanics share a common origin. They both emerge from the necessity that clocks age at rates that are path dependent.

  18. Quantum-mechanical twin paradox

    Science.gov (United States)

    Franson, J. D.

    2016-10-01

    In the twin paradox of special relativity, an observer that travels along an accelerated trajectory at a high velocity will experience a smaller amount of elapsed time than an observer that remains at rest. This illustrates the fact that time is relative unlike the situation in classical physics where time is absolute. In a recent paper, Bushev et al (2016 New J. Phys. 18 093050) showed that the twin paradox can also be demonstrated using a single electron that functions as a quantum-mechanical clock. The wave function of the electron can travel along two different paths simultaneously, which allows a measurement of the difference in proper times along the two trajectories using a single particle. Quantum interference effects show that time cannot be thought of as a classical parameter even when associated with a single clock or observer.

  19. The paradox of energy equivalence

    OpenAIRE

    Isaac, Nick J. B.; Storch, David; Carbone, Chris

    2013-01-01

    Energy equivalence, the notion that population energy flux is independent of body mass, has become a key concept in ecology. We argue that energy equivalence is not an ecological ‘rule’, as claimed, but a flawed concept beset by circular reasoning. In fact, the independence of mass and energy flux is a null hypothesis. We show that our mechanistic understanding of size–density relationships (SDRs) follows directly from this null model and the assumption that energy limits abundance. Paradoxic...

  20. Reinterpretaion of the friendship paradox

    Science.gov (United States)

    Fu, Jingcheng; Wu, Jianliang

    The friendship paradox (FP) is a sociological phenomenon stating that most people have fewer friends than their friends do. It is to say that in a social network, the number of friends that most individuals have is smaller than the average number of friends of friends. This has been verified by Feld. We call this interpreting method mean value version. But is it the best choice to portray the paradox? In this paper, we propose a probability method to reinterpret this paradox, and we illustrate that the explanation using our method is more persuasive. An individual satisfies the FP if his (her) randomly chosen friend has more friends than him (her) with probability not less than 1/2. Comparing the ratios of nodes satisfying the FP in networks, rp, we can see that the probability version is stronger than the mean value version in real networks both online and offline. We also show some results about the effects of several parameters on rp in random network models. Most importantly, rp is a quadratic polynomial of the power law exponent γ in Price model, and rp is higher when the average clustering coefficient is between 0.4 and 0.5 in Petter-Beom (PB) model. The introduction of the probability method to FP can shed light on understanding the network structure in complex networks especially in social networks.

  1. Mechanical paradox: the uphill roller

    Energy Technology Data Exchange (ETDEWEB)

    Cortes, Emilio [Departamento de Fisica, Universidad Autonoma Metropolitana Iztapalapa, PO Box 55-534, Mexico DF 09340 (Mexico); Cortes-Poza, D, E-mail: emil@xanum.uam.mx [Facultad de Ciencias, Universidad Nacional Autonoma de Mexico, Mexico DF, CP 04510 (Mexico)

    2011-11-15

    We analyse in detail the dynamics of a mechanical system which is a rigid body with the geometry of a double cone. This double cone is apparently able to spontaneously roll uphill along inclined rails. The experiment has been known for some centuries, and because of its peculiar behaviour, it has been named 'mechanical paradox'. Although this instrument is well known today, we have not found in the literature a dynamical study like the one we are presenting. A deeper analysis of this mechanical object will allow us to go further than explaining the apparent paradox in the system; it will show interesting features of the dynamics that are not evident or intuitive. In this work, we follow a complete study of the geometry, the kinematic variables and the Lagrangian dynamics of the problem for any set of the angular parameters and initial values, and obtain as a result a full description of the dynamic variables of this mechanical device. In addition to studying the dynamics of the system with the angles that yield the typical paradoxical behaviour, we study carefully what we call the constant potential geometry regime, where the centre of mass maintains its height, and found in this particular case some features of the dynamics which are not common in rolling objects. We believe that this work can offer the student good material to review some fundamental concepts of analytical mechanics.

  2. Are You Insulting Me? Exposure to Alcohol Primes Increases Aggression Following Ambiguous Provocation.

    Science.gov (United States)

    Pedersen, William C; Vasquez, Eduardo A; Bartholow, Bruce D; Grosvenor, Marianne; Truong, Ana

    2014-08-01

    Considerable research has shown that alcohol consumption can increase aggression and produce extremes in other social behaviors. Although most theories posit that such effects are caused by pharmacological impairment of cognitive processes, recent research indicates that exposure to alcohol-related constructs, in the absence of consumption, can produce similar effects. Here we tested the hypothesis that alcohol priming is most likely to affect aggression in the context of ambiguous provocation. Experiment 1 showed that exposure to alcohol primes increased aggressive retaliation but only when an initial provocation was ambiguous; unambiguous provocation elicited highly aggressive responses regardless of prime exposure. Experiment 2 showed that alcohol prime exposure effects are relatively short-lived and that perceptions of the provocateur's hostility mediated effects of prime exposure on aggression. These findings suggest modification and extension of existing models of alcohol-induced aggression. © 2014 by the Society for Personality and Social Psychology, Inc.

  3. Are You Insulting Me? Exposure to Alcohol Primes Increases Aggression Following Ambiguous Provocation

    Science.gov (United States)

    Pedersen, William C.; Vasquez, Eduardo A.; Bartholow, Bruce D.; Grosvenor, Marianne; Truong, Ana

    2014-01-01

    Considerable research has shown that alcohol consumption can increase aggression and produce extremes in other social behaviors. Although most theories posit that such effects are caused by pharmacological impairment of cognitive processes, recent research indicates that exposure to alcohol-related constructs, in the absence of consumption, can produce similar effects. Here we tested the hypothesis that alcohol priming is most likely to affect aggression in the context of ambiguous provocation. Experiment 1 showed that exposure to alcohol primes increased aggressive retaliation but only when an initial provocation was ambiguous; unambiguous provocation elicited highly aggressive responses regardless of prime exposure. Experiment 2 showed that alcohol prime exposure effects are relatively short-lived and that perceptions of the provocateur's hostility mediated effects of prime exposure on aggression. These findings suggest modification and extension of existing models of alcohol-induced aggression. PMID:24854477

  4. Men with high serotonin 1B receptor binding respond to provocations with heightened amygdala reactivity

    DEFF Research Database (Denmark)

    da Cunha-Bang, Sofi; Fisher, Patrick M; Hjordt, Liv V

    2018-01-01

    Serotonin signalling influences amygdala reactivity to threat-related emotional facial expressions in healthy adults, but in vivo serotonin signalling has never been investigated in the context of provocative stimuli in aggressive individuals. The aim of this study was to evaluate associations...... (LV1B) modelling shared correlation between 5-HT1BR binding across multiple brain regions (neocortex, anterior and posterior cingulate cortex, raphe, amygdala, hippocampus and striatum). We tested whether the LV1B was associated with amygdala, striatal and prefrontal reactivity to provocations......, adjusting for age, injected mass and group. Across participants, LV1B was statistically significantly positively associated with amygdala (p = 0.01) but not with striatal (p = 0.2) or prefrontal reactivity to provocations (p = 0.3). These findings provide novel evidence that 5-HT1BR levels are linked...

  5. Dynamic Changes in Heart Rate Variability and Nasal Airflow Resistance during Nasal Allergen Provocation Test

    Directory of Open Access Journals (Sweden)

    Tiina M. Seppänen

    2016-01-01

    Full Text Available Allergic rhinitis is a major chronic respiratory disease and an immunoneuronal disorder. We aimed at providing further knowledge on the function of the neural system in nasal allergic reaction. Here, a method to assess simultaneously the nasal airflow resistance and the underlying function of autonomic nervous system (ANS is presented and used during the nasal provocation of allergic and nonallergic subjects. Continuous nasal airflow resistance and spectral heart rate variability parameters show in detail the timing and intensity differences in subjects’ reactions. After the provocation, the nasal airflow resistance of allergic subjects showed a positive trend, whereas LF/HF (Low Frequency/High Frequency ratio and LF power showed a negative trend. This could imply a gradual sympathetic withdrawal in allergic subjects after the allergen provocation. The groups differed significantly by these physiological descriptors. The proposed method opens entirely new opportunities to research accurately concomitant changes in nasal breathing function and ANS.

  6. Peak nasal inspiratory flow as outcome for provocation studies in allergen exposure chambers

    DEFF Research Database (Denmark)

    Boelke, Georg; Berger, Uwe; Bergmann, Karl-Christian

    2017-01-01

    parameters are preferred. Despite its practicability, the objective parameter peak nasal inspiratory flow (PNIF) has been rarely used for allergy trials in the setting of allergen exposure chambers. This study aims to evaluate PNIF as an outcome parameter for provocation studies in AECs. METHODS...... during a challenge using a portable PNIF meter. RESULTS: 86 subjects participated in 203 challenges, altogether. House dust mite provocations caused the greatest reduction in PNIF values, followed by grass pollen and birch pollen. Provocations with every allergen or pollen concentration led...... to a significant decrease (p flow, height and weight, and inverse correlations between PNIF and total nasal symptom score, nasal congestion score and visual analog scale of overall subjective...

  7. NSAID-exacerbated respiratory disease: a meta-analysis evaluating prevalence, mean provocative dose of aspirin and increased asthma morbidity.

    Science.gov (United States)

    Morales, D R; Guthrie, B; Lipworth, B J; Jackson, C; Donnan, P T; Santiago, V H

    2015-07-01

    The prevalence and mean provocative dose of oral aspirin (MPDA) triggering respiratory reactions in people with asthma have been inconsistently reported, and the relationship between NSAID-exacerbated respiratory disease (NERD) and asthma morbidity was less well quantified. A systematic review was performed by identifying studies diagnosing NERD using blinded, placebo-controlled oral provocation challenge tests (OPCTs) or by self-reported history in people with asthma. Data were extracted, and effect estimates for changes in respiratory function, MPDA and asthma morbidity were pooled using random-effects meta-analysis. The prevalence of NERD in adults with asthma was 9.0% (95% CI 6-12%) using OPCTs and 9.9% (95% CI 9.4-10.5%) using self-reported history from questionnaires. The MPDA in adults with NERD was 85.8 mg (95% CI 73.9-97.6). In people with NERD, the risk of: uncontrolled asthma was increased twofold (RR 1.96 (95% CI 1.25-3.07)); severe asthma and asthma attacks was increased by 60% (RR 1.58 (95% CI 1.15-2.16) and RR 1.59 (95% CI 1.21-2.09), respectively); emergency room visits was increased by 80% (RR 1.79 (95% CI 1.29-2.49)); and asthma hospitalization was increased by 40% (RR 1.37 (95% CI 1.12-1.67)) compared to people with NSAID-tolerant asthma. Respiratory reactions triggered by oral aspirin in people with asthma are relatively common. At the population level, the prevalence of NERD was similar when measured using appropriately conducted OPCTs or by self-reported history. On average, respiratory reactions were triggered by clinically relevant doses of oral aspirin. Asthma morbidity was significantly increased in people with NERD who potentially require more intensive monitoring and follow-up. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  8. Evolution exacerbates the paradox of the plankton.

    Science.gov (United States)

    Shoresh, Noam; Hegreness, Matthew; Kishony, Roy

    2008-08-26

    Can biodiversity evolve and persist in a uniform environment? This question is at the heart of the plankton paradox: in the natural world we observe many species sharing few resources, whereas the principle of competitive exclusion would lead us to expect that only a few species could coexist in such circumstances. To bridge the gap between theory and observation, previous studies have shown that the maximum number of species that can stably coexist is equal to the number of essential resources and that even more species can coexist out of equilibrium. These studies were viewed as a significant step toward a resolution of the paradox. Evolutionary dynamics, however, have been studied in this context only in limited cases, and it is largely unknown how mutations impact ecologically stable multispecies states, and whether large species consortia can spontaneously evolve. In the present study we introduce evolution to the standard ecological model of competition for essential resources. Combining numeric and analytic approaches, we find that ecologically stable species communities are severely destabilized by long-term evolutionary dynamics. Moreover, the number of species in spontaneously evolved consortia is much lower than the number of available resources. Contrary to expectations based on studies of two resources, these limits on biodiversity are not results of the occasional emergence of superspecies, superior to all competitors; nor are they alleviated by the inclusion of tradeoffs in resource utilization. Rather, we show that it is an accelerated depletion of limiting resources, combined with the essentiality of resources to all species, that leads invariably to catastrophic extinctions.

  9. Paradoxical Leadership to Enable Strategic Agility

    OpenAIRE

    Lewis, M. W.; Andriopoulos, C.; Smith, W. K.

    2014-01-01

    Strategic agility evokes contradictions, such as stability-flexibility, commitment-change, and established routines-novel approaches. These competing demands pose challenges that require paradoxical leadership—practices seeking creative, both/and solutions that can enable fast-paced, adaptable decision making. Why is managing paradox critical to strategic agility? And which practices enable leaders to effectively manage tensions? This article describes the paradoxical nature of strategic agil...

  10. The Critical Care Obesity Paradox and Implications for Nutrition Support.

    Science.gov (United States)

    Patel, Jayshil J; Rosenthal, Martin D; Miller, Keith R; Codner, Panna; Kiraly, Laszlo; Martindale, Robert G

    2016-09-01

    Obesity is a leading cause of preventable death worldwide. The prevalence of obesity has been increasing and is associated with an increased risk for other co-morbidities. In the critical care setting, nearly one third of patients are obese. Obese critically ill patients pose significant physical and on-physical challenges to providers, including optimization of nutrition therapy. Intuitively, obese patients would have worse critical care-related outcome. On the contrary, emerging data suggests that critically ill obese patients have improved outcomes, and this phenomenon has been coined "the obesity paradox." The purposes of this review will be to outline the historical views and pathophysiology of obesity and epidemiology of obesity, describe the challenges associated with obesity in the intensive care unit setting, review critical care outcomes in the obese, define the obesity-critical care paradox, and identify the challenges and role of nutrition support in the critically ill obese patient.

  11. The Paradox of Precaution

    Energy Technology Data Exchange (ETDEWEB)

    Bechmann, Gotthard [Forschungszentrum Karlsruhe Technik und Umwelt, Inst. fuer Technikfolgeabschaetzung und Systemanalyse (ITAS), Karlsruhe (Germany)], e-mail: bechmann@itas.fzk.de

    2009-12-15

    The precautionary principle cannot rid itself of risk. In the area of precaution it re-emerges as the risk of precaution. This is due to the fact that precaution is a disposition of the future which can only be decided in the medium of probability/lack of probability. With this type of calculation, we take advantage of the uncertainty of the future and at the same time our own uncertainty to make decisions in the present that can be confirmed or refuted by future states of the present. We will never reach the safe side since the future as future is inherently uncertain. If we take this realisation as a basis, we see that precaution does not mean creating a future free of risk or danger, but that the precautionary principle is a meta-rule how this basic uncertainty can be, and is, processed communicatively, i.e. at the societal level. On this topic a number of remarks: - There are no apodeictic judgements possible with respect to issues of the future, in particular when these are possible catastrophes. Whoever operates in such cases with true assertions disqualifies himself. As we know, this has ruined the political reputation of scientific experts. - We must further do without consensus on principles or on the priority of certain values. Negotiations on decisions must be formulated and understood in a way that they are compatible with a disagreement on principle. Current coordination is then more important than correspondence in the cognitive and evaluative foundations of the assessment of future. - Communication itself is better set up not as communicative action in the sense of Habermas, but on the contrary as strategic action under conditions of uncertainty, that is we have to stay aware that debates related to the future are social constructions and not true statements. - All in all, the demand for 'participation' should be downplayed in favour of strengthening the right to information in order to able to develop the largest possible number of

  12. The Paradox of Precaution

    Energy Technology Data Exchange (ETDEWEB)

    Bechmann, Gotthard (Forschungszentrum Karlsruhe Technik und Umwelt, Inst. fuer Technikfolgeabschaetzung und Systemanalyse (ITAS), Karlsruhe (Germany)), e-mail: bechmann@itas.fzk.de

    2009-12-15

    The precautionary principle cannot rid itself of risk. In the area of precaution it re-emerges as the risk of precaution. This is due to the fact that precaution is a disposition of the future which can only be decided in the medium of probability/lack of probability. With this type of calculation, we take advantage of the uncertainty of the future and at the same time our own uncertainty to make decisions in the present that can be confirmed or refuted by future states of the present. We will never reach the safe side since the future as future is inherently uncertain. If we take this realisation as a basis, we see that precaution does not mean creating a future free of risk or danger, but that the precautionary principle is a meta-rule how this basic uncertainty can be, and is, processed communicatively, i.e. at the societal level. On this topic a number of remarks: - There are no apodeictic judgements possible with respect to issues of the future, in particular when these are possible catastrophes. Whoever operates in such cases with true assertions disqualifies himself. As we know, this has ruined the political reputation of scientific experts. - We must further do without consensus on principles or on the priority of certain values. Negotiations on decisions must be formulated and understood in a way that they are compatible with a disagreement on principle. Current coordination is then more important than correspondence in the cognitive and evaluative foundations of the assessment of future. - Communication itself is better set up not as communicative action in the sense of Habermas, but on the contrary as strategic action under conditions of uncertainty, that is we have to stay aware that debates related to the future are social constructions and not true statements. - All in all, the demand for 'participation' should be downplayed in favour of strengthening the right to information in order to able to develop the largest possible number of

  13. A Note on Faraday Paradoxes

    CERN Document Server

    Auchmann, Bernhard; Russenschuck, Stephan

    2014-01-01

    The validity of the flux rule to determine the electromotive force in a cycle, epsilon = -d Phi/dt, has been the subject of a large amount of controversy since the beginning of electrical technology. Although most authors reach correct conclusions for a class of problems called Faraday paradoxes, the arguments that are used vary and often rely on ad-hoc physical reasoning. A didactic and insightful treatment should be based solely on Maxwell's equations, the constitutive laws, and a detailed study of the mathematics involved.

  14. [Allergy diagnosis in patients with bronchial asthma (bronchial provocation test, skin test and RAST) (author's transl)].

    Science.gov (United States)

    Baur, X; Fruhmann, G; von Liebe, V

    1978-12-15

    87 patients with bronchial asthma underwent skin test, RAST and measurment of airway resistance before and after inhalation of control solution as well as at least 10 times after each of one to four bronchial provocations (making up a total of 171 tests) with extracts of house dust, house dust mite, animal dander, mould spores and pollen in increasing concentrations. An actual clinical significance of the skin test reactions was found in 60% of all cases and of the RAST results in 66% of all cases. The overall agreement between skin test results and RAST results was 61%. The correlations between the different tests depended on the degree of hypersensitivity, on the tested allergen and on whether the results of skin test and RAST, respectively, were positive or negative. There existed a good correlation between the results of all three test methods and case history only for pollen allergens and animal dander. Noticeably often negative RAST results with house dust and mould spores, as well as positive skin tests with house dust mite and mould spores could not be confirmed by the provocation test. Important indications for a bronchial provocation test in asthmatics are doubtful case history, doubtful skin test or RAST results with the problem-allergens house dust, house dust mite and mould spores; the bronchial provocation test is especially commendable when drastic or cumbersome therapeutic measures (immunotherapy, change of home, change of job) are to follow or if late asthmatic reactions are expected.

  15. Measured Effects of Provocation and Emotional Mastery Techniques in Fostering Emotional Intelligence among Nigerian Adolescents

    Science.gov (United States)

    Ogunyemi, Ajibola Olusoga

    2008-01-01

    Introduction: This study investigated the effects of provocation and emotional mastery programmes at fostering emotional intelligence of Nigerian adolescents. The study also aimed to establish whether gender will moderate the effects of the two techniques on emotional intelligence skills of adolescents. Method: The study employed a…

  16. Social provocation modulates decision making and feedback processing: Examining the trajectory of development in adolescent participants

    Directory of Open Access Journals (Sweden)

    Hannah L. Pincham

    2015-10-01

    Full Text Available Increasingly, research is turning to the ways in which social context impacts decision making and feedback processing in adolescents. The current study recorded electroencephalography to examine the trajectory of development across adolescence, with a focus on how social context impacts cognition and behaviour. To that end, younger (10–12 years and older (14–16 years adolescents played a modified Taylor Aggression Paradigm against two virtual opponents: a low-provoker and a high-provoker. During the task's decision phase (where participants select punishment for their opponent, we examined two event-related potentials: the N2 and the late positive potential (LPP. During the outcome phase (where participants experience win or loss feedback, we measured the feedback related negativity (FRN. Although N2 amplitudes did not vary with provocation, LPP amplitudes were enhanced under high provocation for the younger group, suggesting that emotional reactivity during the decision phase was heightened for early adolescents. During the outcome phase, the FRN was reduced following win outcomes under high provocation for both groups, suggesting that a highly provocative social opponent may influence the reward response. Collectively, the data argue that social context is an important factor modulating neural responses in adolescent behavioural and brain development.

  17. Violent offenders respond to provocations with high amygdala and striatal reactivity

    DEFF Research Database (Denmark)

    da Cunha-Bang, Sofi; Fisher, Patrick M.; Hjordt, Liv Vadskjær

    2017-01-01

    monetary rewards. The violent offenders behaved more aggressively than controls (aggression frequency 150 us 84, P = 0.03) and showed significantly higher brain reactivity to provocations within the amygdala and striatum, as well as reduced amygdala-prefrontal and striato-prefrontal connectivity. Amygdala...

  18. Laryngeal effects of nasal allergen provocation in singers with allergic rhinitis

    NARCIS (Netherlands)

    Verguts, Monique M. L.; Eggermont, Anita; Decoster, Wivine; de Jong, Felix I. C. R. S.; Hellings, Peter W.

    2011-01-01

    In spite of our recent insight into nasobronchial interaction mechanisms in allergic airway disease, the association between allergic rhinitis and voice complaints remains obscure. To evaluate the effects of nasal allergen provocation and seasonal grass pollen exposure on subjective and objective

  19. Violent offenders respond to provocations with high amygdala and striatal reactivity

    DEFF Research Database (Denmark)

    da Cunha-Bang, Sofi; Fisher, Patrick M; Hjordt, Liv Vadskjær

    2017-01-01

    magnetic resonance imaging point-subtraction aggression paradigm in 44 men, of whom 18 were incarcerated violent offenders and 26 were control non-offenders. We measured brain activation following provocations (monetary subtractions), while the subjects had the possibility to behave aggressively or pursue...

  20. Virtue Acquisition: The Paradox of Striving

    Science.gov (United States)

    Snow, Nancy

    2016-01-01

    Aristotelian-inspired accounts of virtue acquisition stress guided practice and habituated action to develop virtue. This emphasis on action can lead to the "paradox of striving". The paradox occurs when we try too hard to act well and thereby spoil our efforts. I identify four forms of striving--forcing, impulsivity, overthinking, and…

  1. Negative freedom and the liberal paradoxes

    NARCIS (Netherlands)

    van Hees, M.V.B.P.M

    In their game-theoretic formulations, the liberal paradoxes of Amartya Sm and Alan Gibbard show a tension between freedom on the one hand, and Pareto optimality and stability on the other. This article examines what happens to the liberal paradoxes if a negative conception of freedom is used. Given

  2. The twin paradox and Mach's principle

    CERN Document Server

    Lichtenegger, Herbert I M

    2009-01-01

    The problem of absolute motion in the context of the twin paradox is discussed. It is shown that the various versions of the clock paradox feature some aspects which Mach might have been appreciated. However, the ultimate cause of the behavior of the clocks must be attributed to the autonomous status of spacetime, thereby proving the relational program advocated by Mach as impracticable.

  3. The Asymptotic Approach to the Twin Paradox

    Directory of Open Access Journals (Sweden)

    Dumitru S.

    2008-04-01

    Full Text Available The argument of twins’ asymmetry, essentially put forward in the common solution of the Twin Paradox, is revealed to be inoperative in some asymptotic situations in which the noninertial effects are insignificant. Consequently the respective solution proves itself as unreliable thing and the Twin Paradox is re-established as an open problem which require further investigations.

  4. The twin paradox and Mach's principle

    Science.gov (United States)

    Lichtenegger, H.; Iorio, L.

    2011-12-01

    The problem of absolute motion in the context of the twin paradox is discussed. It is shown that the various versions of the clock paradox feature some aspects which Mach might have appreciated. However, the ultimate cause of the behavior of the clocks must be attributed to the autonomous status of spacetime, thereby proving the relational program advocated by Mach as impracticable.

  5. On the Twin Non-paradox

    OpenAIRE

    Kracklauer, A. F.; Kracklauer, P. T.

    2000-01-01

    It is shown that the "twin paradox" arises from comparing unlike entities, namely perceived intervals with eigenintervals. When this lacuna is closed, it is seen that there is no twin paradox and that eigentime can serve as the independent variable for mechanics in Special Relativity.

  6. The Asymptotic Approach to the Twin Paradox

    Directory of Open Access Journals (Sweden)

    Dumitru S.

    2008-04-01

    Full Text Available The argument of twins' asymmetry, essentially put forward in the common solution of the Twin Paradox, is revealed to be inoperative in some asymptotic situations in which the noninertial effects are insignificant. Consequently the respective solution proves itself as unreliable thing and the Twin Paradox is re-established as an open problem which require further investigations.

  7. Contralateral paradoxical response to chemotherapy in tuberculous ...

    African Journals Online (AJOL)

    Pleural effusions may occur as a complication of primary tuberculosis or an established pulmonary or extrapulmonary infection. New formation or expansion of a tuberculous lesion during chemotherapy is referred to as paradoxical response. Paradoxical response has been described to occur weeks or months after starting ...

  8. Unearthing the Banach–Tarski Paradox

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 22; Issue 10. Unearthing the Banach–Tarski Paradox. B Sury. General Article Volume 22 Issue 10 October ... The paradox of the title can be informally described as follows.Consider the earth including the inside stuff. It is possibleto decompose this solid ...

  9. Clinical tube weaning supported by hunger provocation in fully-tube-fed children.

    Science.gov (United States)

    Hartdorff, Caroline M; Kneepkens, C M Frank; Stok-Akerboom, Anita M; van Dijk-Lokkart, Elisabeth M; Engels, Michelle A H; Kindermann, Angelika

    2015-04-01

    Children with congenital malformations, mental retardation, and complex early medical history frequently have feeding problems. Although tube feeding is effective in providing the necessary energy and nutrients, it decreases the child's motivation to eat and may lead to oral aversion. In this study, we sought to confirm our previous results, showing that a multidisciplinary clinical hunger provocation program may lead to quick resumption of oral feeding. In a crossover study, 22 children of 9 to 24 months of age who were fully dependent on tube feeding were randomly assigned to one of two groups: group A, intervention group (2-week multidisciplinary clinical hunger provocation program); and group B, control group (4-week outpatient treatment by the same multidisciplinary team). Patients failing one treatment were reassigned to the other treatment group. Primary outcome measures were at least 75% orally fed at the conclusion of the intervention and fully orally fed and gaining weight 6 months after the intervention. In group A, 9/11 patients were successfully weaned from tube feeding (2 failures: 1 developed ulcerative colitis, 1 drop-out). In group B, only 1 patient was weaned successfully; 10/11 were reassigned to the clinical hunger provocation program, all being weaned successfully. Six months after the intervention, 1 patient had to resume tube feeding. In total, in the control group, 1/11 (9%) was weaned successfully as compared with 18/21 (86%) in the hunger provocation group (P hunger provocation is an effective short-term intervention for weaning young children from tube feeding.

  10. [Five paradoxes in health promotion].

    Science.gov (United States)

    López-Dicastillo, Olga; Canga-Armayor, Navidad; Mujika, Agurtzane; Pardavila-Belio, Miren Idoia; Belintxon, Maider; Serrano-Monzó, Inmaculada; Pumar-Méndez, María J

    The World Health Organization states that health promotion is a key strategy to improve health, and it is conceived as a global process of enabling people to increase control over, and to improve, their health. Health promotion does not focus solely on empowering individuals dealing with their knowledge, attitudes and skills, but it also takes political, social, economic and environmental aspects influencing health and wellbeing into account. The complexity of applying these concepts is reflected in the five paradoxes in health promotion; these arise in between the rhetoric in health promotion and implementation. The detected paradoxes which are described herein involve the patient versus the person, the individual versus the group, disease professionals versus health professionals, disease indicators versus health indicators, and health as an expense versus health as an investment. Making these contradictions explicit can help determine why it is so complex to put the concepts related to health promotion into practice. It can also help to put forward aspects that need further work if health promotion is to put into practice. Copyright © 2017 SESPAS. Publicado por Elsevier España, S.L.U. All rights reserved.

  11. Direct oral provocation tests in non-immediate mild cutaneous reactions related to beta-lactam antibiotics.

    Science.gov (United States)

    Vezir, Emine; Dibek Misirlioglu, Emine; Civelek, Ersoy; Capanoglu, Murat; Guvenir, Hakan; Ginis, Tayfur; Toyran, Muge; Kocabas, Can N

    2016-02-01

    Skin testing has a limited role in the diagnosis of non-immediate beta-lactam hypersensitivity in children. The aim of this study was to report the results of oral provocation tests performed without skin tests in children with non-immediate mild cutaneous reactions without systemic symptoms caused by beta-lactam antibiotics. Oral provocation tests with suspected antibiotics were performed to patients with non-immediate mild cutaneous reactions without systemic symptoms caused by beta-lactam antibiotics. Skin tests were not performed before provocation tests. A total of five doses were administered with half-an-hour intervals in increasing doses. Provocation was continued for 5 days. A total of 119 patients with a median age of 4.3 (IQR: 2-7.5) years, of whom 58% were males, were included in the study. Amoxicillin-clavulanic acid was the most frequently responsible agent in 87 (73.1%) patients, and most common type of rash was maculopapular in 74 (62.2%) patients. Four patients (3.4%) had an urticarial reaction during the provocation test. We did not experience any severe reactions during oral provocation test without previous skin tests performed to children with non-immediate mild cutaneous reactions without systemic symptoms. Omitting skin tests before oral provocation test in this group of children can help decreasing the burden of allergy clinics and alleviating the discomfort of children. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  12. Molecular Pathological Epidemiology Gives Clues to Paradoxical Findings

    Science.gov (United States)

    Nishihara, Reiko; VanderWeele, Tyler J.; Shibuya, Kenji; Mittleman, Murray A.; Wang, Molin; Field, Alison E.; Giovannucci, Edward; Lochhead, Paul; Ogino, Shuji

    2015-01-01

    A number of epidemiologic studies have described what appear to be paradoxical associations, where an incongruous relationship is observed between a certain well-established risk factor for disease incidence and favorable clinical outcome among patients with that disease. For example, the “obesity paradox” represents the association between obesity and better survival among patients with a certain disease such as coronary heart disease. Paradoxical observations cause vexing clinical and public health problems as they raise questions on causal relationships and hinder the development of effective interventions. Compelling evidence indicates that pathogenic processes encompass molecular alterations within cells and the microenvironment, influenced by various exogenous and endogenous exposures, and that interpersonal heterogeneity in molecular pathology and pathophysiology exists among patients with any given disease. In this article, we introduce methods of the emerging integrative interdisciplinary field of molecular pathological epidemiology (MPE), which is founded on the unique disease principle and disease continuum theory. We analyze and decipher apparent paradoxical findings, utilizing the MPE approach and available literature data on tumor somatic genetic and epigenetic characteristics. Through our analyses in colorectal cancer, renal cell carcinoma, and glioblastoma (malignant brain tumor), we can readily explain paradoxical associations between disease risk factors and better prognosis among disease patients. The MPE paradigm and approach can be applied to not only neoplasms but also various non-neoplastic diseases where there exists indisputable ubiquitous heterogeneity of pathogenesis and molecular pathology. The MPE paradigm including consideration of disease heterogeneity plays an essential role in advancements of precision medicine and public health. PMID:26445996

  13. Effect of a new selective H1 receptor antagonist (levocabastine) in a nasal and conjunctival provocation test.

    Science.gov (United States)

    Pécoud, A; Zuber, P; Kolly, M

    1987-01-01

    Levocabastine is a new selective H1 receptor antagonist. The effect of the drug administered locally was compared to placebo in a quantified nasal and conjunctival provocation test with allergens performed in patients allergic to grass pollen. In the nasal provocation test, levocabastine was able to increase the 'reaction threshold' (dose of allergen necessary to trigger allergic symptoms) in 9 out of 12 patients; the drug inhibited rhinorrhea and sneezing, but not nasal obstruction. In the conjunctival provocation test, the 'reaction threshold' clearly increased in 10 out of 11 patients. The local administration of levocabastine might be useful in allergic rhinitis and conjunctivitis.

  14. Paradoxical Behavior of Granger Causality

    Science.gov (United States)

    Witt, Annette; Battaglia, Demian; Gail, Alexander

    2013-03-01

    Granger causality is a standard tool for the description of directed interaction of network components and is popular in many scientific fields including econometrics, neuroscience and climate science. For time series that can be modeled as bivariate auto-regressive processes we analytically derive an expression for spectrally decomposed Granger Causality (SDGC) and show that this quantity depends only on two out of four groups of model parameters. Then we present examples of such processes whose SDGC expose paradoxical behavior in the sense that causality is high for frequency ranges with low spectral power. For avoiding misinterpretations of Granger causality analysis we propose to complement it by partial spectral analysis. Our findings are illustrated by an example from brain electrophysiology. Finally, we draw implications for the conventional definition of Granger causality. Bernstein Center for Computational Neuroscience Goettingen

  15. The paradox of atheoretical classification

    DEFF Research Database (Denmark)

    Hjørland, Birger

    2016-01-01

    A distinction can be made between “artificial classifications” and “natural classifications,” where artificial classifications may adequately serve some limited purposes, but natural classifications are overall most fruitful by allowing inference and thus many different purposes. There is strong...... support for the view that a natural classification should be based on a theory (and, of course, that the most fruitful theory provides the most fruitful classification). Nevertheless, atheoretical (or “descriptive”) classifications are often produced. Paradoxically, atheoretical classifications may...... be very successful. The best example of a successful “atheoretical” classification is probably the prestigious Diagnostic and Statistical Manual of Mental Disorders (DSM) since its third edition from 1980. Based on such successes one may ask: Should the claim that classifications ideally are natural...

  16. Paradoxes unbounded: Practising community making

    Directory of Open Access Journals (Sweden)

    Tess Maginess

    2011-10-01

    Full Text Available The first section of this paper is a discussion of the paradoxes contained in definitionsof the word 'community' and deliberately foregrounds and makes problematicconflicting meanings before arguing for a third definition and practice of community.This third definition and practice celebrates and even transcends contradictions withinan active learning model of education in the community, aimed at tackling inequalityand prejudice. The second section offers an autocritical narrative account of aneducation in the community project that illustrates how such a practice of communitymaking can be achieved within an educational framework in which pupil is teacher andteacher is pupil and in which an imaginative, creative approach is deployed toconstruct a community making practice. The paper draws on understandings fromcommunity development, inclusive and creative education, emancipatory actionresearch, postcolonial and post-structuralist theory.

  17. The Immigrant Paradox in Children and Adolescents: Is Becoming American a Developmental Risk?

    Science.gov (United States)

    Coll, Cynthia Garcia, Ed.; Marks, Amy Kerivan, Ed.

    2011-01-01

    Many academic and public policies promote rapid immigrant assimilation. Yet, researchers have recently identified an emerging pattern, known as the "immigrant paradox," in which assimilated children of immigrants experience diminishing developmental outcomes and educational achievements. This volume examines these controversial findings by asking…

  18. [The effects of media violence on aggression: focus on the role of anger evoked by provocation].

    Science.gov (United States)

    Yukawa, S; Endo, K; Yoshida, F

    2001-04-01

    This study investigated the effects of anger evoked by earlier provocation on cognition, emotion, and aggressive behavior after being exposed to media violence. Sixty male undergraduates participated in the experiment. Before viewing one of three videos (either highly violent, violent with high entertainment, or nonviolent), half of the subjects were provoked by a confederate posing as another subject. Subjects' heart rates and eyeblink rates were recorded while viewing the video. After viewing the video, subjects described their thoughts that occurred while watching the video and rated their affective reactions toward the video. Finally, subjects' aggressive behavior toward the confederate was measured. Results of covariance structure analysis suggested that (a) anger evoked by provocation and high level of violence in videos additively elicited negative cognition and affect, which further facilitated aggressive behavior, and (b) high level of entertainment in videos elicited positive cognition and affect, which alleviated negative cognition and affect.

  19. Experimental panic provocation in healthy man—a translational role in anti-panic drug development?

    Science.gov (United States)

    Kellner, Michael

    2011-01-01

    Experimental neurochemical provocation of panic attacks in susceptible human subjects has considerably expanded our knowledge of the pathophysiology and psychopharmacology of panic disorder. Some panicogens also elicit short-lived panic-like states in healthy man. This offers the opportunity to assess the anti-panic action of drugs in proof-of-concept studies. However, from current data it is still unclear whether experimental panic in healthy man is a valid translational model. Most such studies in healthy volunteers have been performed using a cholecystokinin tetrapeptide (CCK-4) challenge. While CCK-4 panic was blocked by alprazolam pretreatment, escitalopram showed negative results in healthy man. Preliminary findings on novel investigational drugs and a few problematic results will be reviewed. Small sample sizes in many panic provocation studies, lack of dose-response aspects, and still-insufficient knowledge about the biological underpinning of experimental and spontaneous panic limit the interpretation of existing findings and should inspire further research. PMID:22275853

  20. Bronchial provocation testing does not detect exercise-induced laryngeal obstruction

    DEFF Research Database (Denmark)

    Walsted, Emil Schwarz; Hull, James H; Sverrild, Asger

    2017-01-01

    and possible asthma referred over 6 months. All subjects received comprehensive assessment including a detailed clinical evaluation; pulmonary function testing, indirect and direct bronchial provocation testing, and CLE testing. RESULTS: Out of 37 subjects, moderate or severe EILO was diagnosed in 8 subjects......INTRODUCTION: Exercise-induced laryngeal obstruction (EILO) is a key differential diagnosis for asthma in the presence of exertional respiratory symptoms. Continuous laryngoscopy during exercise (CLE), the current gold standard diagnostic test for EILO, has practical limitations. We aimed...... (22%, all female) while 5 (14%) had both asthma and EILO. There was no correlation between degree of EILO during CLE and mean decrease in forced inspiratory flow (%FIF50) obtained during neither the Methacholine (r = -0.15; p = 0.38) nor Mannitol (r = 0.04; p = 0.84) provocation tests. CONCLUSION...

  1. Teens With Heavy Prenatal Cocaine Exposure Respond to Experimental Social Provocation with Escape Not Aggression

    OpenAIRE

    Greenwald, M.K.; Chiodo, L.M.; Hannigan, J.H.; Sokol, R.J.; Janisse, J.; Delaney-Black, V.

    2010-01-01

    Preclinical data show that, compared to no exposure, prenatal cocaine exposure (PCE) has age-dependent effects on social interaction and aggression. The aim of this clinical study was to determine how heavy/persistent PCE – after controlling for other prenatal drug exposures, sex and postnatal factors – predicts behavioral sensitivity to provocation (i.e., reactive aggression) using a well-validated human laboratory model of aggression. African American teens (mean = 14.2 yrs old) with histor...

  2. North Korea’s Provocation and Escalation Calculus: Dealing with the Kim Jong-un Regime

    Science.gov (United States)

    2015-08-01

    rhetoric coming from Pyongyang during the Foal Eagle/Key Resolve exercises was in many respects unprecedented. Pyongyang moved up the escalatory ladder...2014 Foal Eagle/Key Resolve exercise, there were concerns in both South Korea and the United States that North Korea would respond with provocations...of the spokesman for the KPA General Staff in response to the annual Key Resolve/ Foal Eagle exercise. The wording of the statement seemed designed to

  3. Stratifying migraine patients based on dynamic pain provocation over the upper cervical spine

    OpenAIRE

    Luedtke, Kerstin; May, Arne

    2017-01-01

    Background Migraine patients usually report a high prevalence of neck pain preceding or during the migraine attack. A recent investigation of musculoskeletal dysfunctions in migraine patients concluded that neck pain is not simply a symptom of the migraine attack but corresponds to identifiable muscle and joint alterations. Particularly pain provocation using palpation of the joints in the upper cervical spine was significantly more prevalent in patients with migraine than in headache-free pa...

  4. Can migraine aura be provoked experimentally? A systematic review of potential methods for the provocation of migraine aura

    DEFF Research Database (Denmark)

    Lindblad, Marianne; Hougaard, Anders; Amin, Faisal Mohammad

    2017-01-01

    Background The nature of the migraine aura and its role in migraine pathophysiology is incompletely understood. In particular, the mechanisms underlying aura initiation and the causal relation between aura and headache are unknown. The scientific investigation of aura in patients is only possible...... if aura can be triggered. This paper reviews potential methods for the experimental provocation of migraine aura. Methods We systematically searched PubMed for studies of experimental migraine provocation, including case reports of patients with aura and reports of the occurrence of aura following...... exposure to any kind of suspected trigger. Results We identified 21 provocation studies, using 13 different prospective provocation methods, and 34 case reports. In the prospective studies, aura were reported following the administration of intravenous and sublingual glyceryl trinitrate, visual stimulation...

  5. Symptoms suggestive of dumping syndrome after provocation in patients after laparoscopic sleeve gastrectomy.

    Science.gov (United States)

    Tzovaras, George; Papamargaritis, Dimitris; Sioka, Eleni; Zachari, Eleni; Baloyiannis, Ioannis; Zacharoulis, Dimitris; Koukoulis, George

    2012-01-01

    Dumping syndrome is a well-known complication after upper gastrointestinal (GI) surgery. There are scarce data in the literature about the incidence of dumping after bariatric operations but, certainly no relation between this syndrome and laparoscopic sleeve gastrectomy (LSG) has been attempted. We conducted a prospective clinical study in order to evaluate the potential presence, incidence and severity of Dumping syndrome after LSG. Thirty one non-diabetic morbidly obese patients (eight male, 23 female) eligible for LSG were evaluated. Median age was 38 (22-58 years) and mean body mass index (BMI) was 45.55 (± 5.37). The diagnosis of dumping syndrome was based on clinical provocation of signs and symptoms using an oral glucose challenge before and 6 weeks after the operation. The Sigstad's dumping score was estimated in order to separate dumpers from non-dumpers, and the Arts questionnaire was completed to distinguish between early and late dumping. Moreover, blood glucose levels during the oral glucose challenge were measured. No patient had symptoms of dumping after provocation preoperatively, whereas after LSG 9 patients (29%) experienced definite dumping and other 5 patients (16%) symptoms suggestive of dumping syndrome. Arts' questionnaire demonstrated that dumping occurrence after LSG was associated with early symptoms. Late hypoglycaemia occurred in one patient. A significant proportion of patients after LSG experienced dumping syndrome upon provocation. It seems that LSG should no longer be considered as a pure restrictive procedure, and it might be an option for heavy sweeters by changing their food tolerance patterns.

  6. six six six paradox : [luuletused] / Triin Tasuja

    Index Scriptorium Estoniae

    Tasuja, Triin

    2008-01-01

    Sisu: six six six paradox ; cat stevens ; "vahel tundub, et mu ümber..." ; sääse ; Salaalaealised ; kolkalapsed ; longin mööda lumiseid tänavaid ; punkrock dekadents ; "Igast kirjaneitsist..." ; "mina olengi see saikochick..."

  7. A Solution of the Mitra Paradox

    Directory of Open Access Journals (Sweden)

    Øyvind Grøn

    2016-11-01

    Full Text Available The “Mitra paradox” refers to the fact that while the de Sitter spacetime appears non-static in a freely falling reference frame, it looks static with reference to a fixed reference frame. The coordinate-independent nature of the paradox may be gauged from the fact that the relevant expansion scalar, θ = 3 Λ , is finite if Λ > 0 . The trivial resolution of the paradox would obviously be to set Λ = 0 . However, here it is assumed that Λ > 0 , and the paradox is resolved by invoking the concept of “expansion of space”. This is a reference-dependent concept, and it is pointed out that the solution of the Mitra paradox is obtained by taking into account the properties of the reference frame in which the coordinates are co-moving.

  8. Cannabinoid Hyperemesis Syndrome: A Paradoxical Cannabis Effect

    National Research Council Canada - National Science Library

    Figueroa-Rivera, Ivonne Marie; Estremera-Marcial, Rodolfo; Sierra-Mercado, Marielly; Gutiérrez-Núñez, José; Toro, Doris H

    2015-01-01

    Despite well-established antiemetic properties of marijuana, there has been increasing evidence of a paradoxical effect in the gastrointestinal tract and central nervous system, given rise to a new...

  9. Laying the ghost of twin paradox

    National Research Council Canada - National Science Library

    Popović Marko

    2009-01-01

    .... Entropy, extent of metabolic reaction, and temperature are Lorentz invariant, so these facts make twin paradox impossible because there is no way for one twin to age slower than the other even...

  10. Time, Topology and the Twin Paradox

    CERN Document Server

    Luminet, J -P

    2009-01-01

    The twin paradox is the best known thought experiment associated with Einstein's theory of relativity. An astronaut who makes a journey into space in a high-speed rocket will return home to find he has aged less than a twin who stayed on Earth. This result appears puzzling, since the situation seems symmetrical, as the homebody twin can be considered to have done the travelling with respect to the traveller. Hence it is called a "paradox". In fact, there is no contradiction and the apparent paradox has a simple resolution in Special Relativity with infinite flat space. In General Relativity (dealing with gravitational fields and curved space-time), or in a compact space such as the hypersphere or a multiply connected finite space, the paradox is more complicated, but its resolution provides new insights about the structure of spacetime and the limitations of the equivalence between inertial reference frames.

  11. The Asymptotic Approach to the Twin Paradox

    National Research Council Canada - National Science Library

    Spiridon Dumitru

    2008-01-01

    The argument of twins' asymmetry, essentially put forward in the common solution of the Twin Paradox, is revealed to be inoperative in some asymptotic situations in which the noninertial effects are insignificant...

  12. The Asymptotic Approach to the Twin Paradox

    National Research Council Canada - National Science Library

    Dumitru S

    2008-01-01

    The argument of twins’ asymmetry, essentially put forward in the common solution of the Twin Paradox, is revealed to be inoperative in some asymptotic situations in which the noninertial effects are insignificant...

  13. Compatibility of Clinical Manifestation with Skin Prick Test Result and Food Provocation Test in Food Cross Reaction

    OpenAIRE

    Lubis, Azwin; Barlianto, Wisnu; Endaryanto, Anang; Harsono, Ariyanto

    2017-01-01

    Background: Subjective diagnostic test of food allergy is hugely biased, resulting in irrational diet avoidance. Additional objective tools by skin prick test following food provocation test resulting more accurate cause and prevalence on population. Purpose: To evaluate the compatibility of clinical symptoms with skin prick test and provocation test for imunoglobulin E (IgE) mediated food allergy in Dr. Soetomo Hospital Surabaya. Methods: Cross sectional observational analytic study. Patient...

  14. Family Fathers Lost in Theatre Paradox

    DEFF Research Database (Denmark)

    Kuhlmann, Annelis

    2008-01-01

    Diderot's influence on theatre is well known through The Paradox of Acting (Paradoxe sur le comédien). However, Diderot also wrote a few drames bourgeois, among which is The Family Father (Le Père de famille), which still in Diderot's days was edited in Copenhagen in French, and which in Danish...... theatre reception turned out to become a real drama....

  15. Susceptibility to UV-A and UV-B provocation does not correlate with disease severity of polymorphic light eruption.

    Science.gov (United States)

    Janssens, Artiena Soe; Pavel, Stan; Ling, Tsui; Winhoven, Sandra Maria; Anastasopoulou, Nikoletta; Stratigos, Alexander; Antoniou, Christina; Diepgen, Thomas; de Gruijl, Frank; Rhodes, Lesley Elisabeth

    2007-05-01

    To examine whether the ease of disease provocation by UV-A and/or UV-B radiation correlates with clinical features of polymorphic light eruption (PLE), including those indicative of disease severity. Intervention study. One hundred forty-three patients with PLE. Provocation testing with broadband UV-A and UV-B lamps. Additionally, a range of clinical characteristics of the disorder, including a 5-item PLE severity score, was assessed by questionnaire. Percentage of PLE rash induction by UV-A and UV-B provocation, differences between the skin types, and correlation between the results of provocation and a range of clinical characteristics of the disorder, including a 5-item PLE severity score. Rash provocation was seen in 78.3% of patients after UV-A and in 46.7% after UV-B exposure. Neither UV-A nor UV-B provocation showed a significant association with the total 5-item severity score. The UV-B reactivity was associated with a high score on the severity item "number of months affected per year" (P = .04), whereas UV-A responsiveness showed a tendency for association with facial involvement (P = .06). The objective assessment of UV-A or UV-B susceptibility in this large group of patients showed no significant relationship with clinical disease severity.

  16. A Case of Tuberculous Meningitis with Paradoxical Response in a 14-Year-Old Boy

    Directory of Open Access Journals (Sweden)

    Murat Özer

    2016-01-01

    Full Text Available A clinical or radiological worsening of already existing lesions or an emergence of new lesions after beginning treatment in patients with tuberculosis (TB is referred to as the paradoxical response. This has aroused suspicion regarding the accuracy of diagnosis, the possibilities of treatment failure, or the presence of another underlying disease, and thus it is an important topic for clinicians to understand. In this article, the development of a paradox reaction in a 14-year-old male patient diagnosed with and treated for tuberculosis meningitis is reported. This pediatric patient with a healthy immune system is treated with steroids successfully and reported to elucidate the importance of managing the paradox of TB progression in spite of the appropriate anti-TB medications.

  17. A qualitative investigation of the effects of psycho-spiritual integrative therapy on breast cancer survivors' experience of paradox.

    Science.gov (United States)

    Patel, Kirti; Wall, Kathleen; Bott, Nicholas T; Katonah, Doralee Grindler; Koopman, Cheryl

    2015-02-01

    This study is an exploratory, qualitative investigation of breast cancer survivors' experiences of paradox, following psycho-spiritual integrative therapy (PSIT). Previous studies examined the role of paradox in spiritual development among women diagnosed with cancer; this study investigated a psycho-spiritual intervention for multicultural cancer survivors. Twelve multicultural breast cancer survivors, from a sample of 30 women participants in an 8-week PSIT group intervention, were recruited from oncologists, hospitals, support groups, outpatient oncology centers, surgeons, radiation therapy centers, cancer events, and websites. We conducted semi-structured, open-ended interviews lasting 1-2 h regarding participants' experiences coping with cancer and their experience of PSIT. We transcribed interviews and conducted blind searches for both new and previously identified paradoxes and themes. Two previously identified themes emerged: (1) attempting to maintain coherence in new and old ways and (2) letting go of ultimate control in life. Additionally, three novel themes emerged: (1) interconnection between helpers and hinderers, (2) spiritual edges and tensions, and (3) new paths to empowerment. Results of this qualitative analysis indicate participants experienced previously identified themes and experienced an expanded range of paradoxes. After learning compassionate acceptance through PSIT, breast cancer survivors develop greater access to the multidimensionality of paradoxes, which can go beyond a binary (either/or) construction to a more interdependent (both/and) relationship. Devoting greater attention to investigating and understanding how diverse participants engage with and move through paradoxical change processes could enhance the effectiveness of existential and spiritual interventions.

  18. Phosphorus and Water Quality Paradox

    Science.gov (United States)

    Pant, H. K.

    2008-12-01

    Paradoxically, phosphorus (P) is one of the major nutrients for higher agricultural production, as well as it causes eutrophication/algal blooms in aquatic and semi-aquatic systems. Phosphorus loadings from agricultural/urban runoffs into lakes and rivers are becoming a global concern for the protection of water quality. Artificial wetlands are considered as a low cost alternative for treating wastewater including removal of P from sources such as agricultural and urban runoffs. However, the selection of the construction site may well determine the effectiveness of these wetlands. Studies show that P transformations in sediments/ soils are crucial for P sequestration in a wetland rather than the amounts of native P. Using 31Phosphorus Nuclear Magnetic Resonance Spectroscopy (31P NMR), previously unreported an active organic P form, phosphoarginine, was identified, and the study indicates that abandonment of P impacted sites may not solve the P loading problem to the water bodies as the organic P compounds would not be as stable as they were thought, thus, can play a detrimental role in eutrophication of water bodies, after all.

  19. New aspects of paradoxical embolism.

    Science.gov (United States)

    Lehmeyer, S; Lindhoff-Last, E

    2011-01-01

    Paradoxical emboli have their origin in the low-pressure venous system and can cause ischemic stroke or peripheral arterial embolism through a cardiac or pulmonary shunt. In most cases, a patent foramen ovale (PFO) is found. About 20 % of the population has a patent foramen ovale. This review gives insight into publications concerning the association between the presence of a patent foramen ovale and cryptogenic stroke; the association of PFO, coagulation disorders and stroke; and recurrence rates of stroke in patients with PFO. Diagnostic features are discussed, as are the different therapy modalities, taking existing national and international guidelines into account. Also, our own recommendations are given. In addition some new information on the potential improvement of migraine after PFO closure is discussed. It is widely accepted that the optimal therapy for the prevention of recurrent stroke in patients with PFO and cryptogenic stroke has not yet been found. Randomized, controlled clinical studies are ongoing in the United States and will give even more insight and answer open questions in the future.

  20. The Paradox of Equal Opportunities

    Directory of Open Access Journals (Sweden)

    Mitja Sardoč

    2014-06-01

    Full Text Available The basic assumption of the idea of equal opportunities is based on the assertion that all individuals competing for an advantaged social position should have equal opportunities, i.e., that each and every one of them should have fair opportunities to achieve a particular goal. Despite the fact that equal opportunities is one of the basic mechanisms for a just distribution of advantageous social positions, the idea of fair equality of opportunity remains divided between different competing political projects, e.g., egalitarian liberalism, libertarian political theory, multiculturalism, etc. This paper examines two basic dimensions of equal opportunities to which existing conceptions fail to offer a unanimous answer, i.e., a the issue of fairness and b the issue of the currency of fairness. The concluding part of this paper presents two basic paradoxes that determine both the direction of the discussion as well as the possible solutions to the achievement of fair equal opportunities as part of any process for competing for advantageous social positions.

  1. Preoperative cellulose porous beads for therapeutic embolization of meningioma: provocation test and technical considerations

    Energy Technology Data Exchange (ETDEWEB)

    Kai, Yutaka; Morioka, Motohiro; Yano, Shigetoshi; Nakamura, Hideo; Makino, Keishi; Mizuno, Takamasa; Takeshima, Hideo; Kuratsu, Jun-ichi [Kumamoto University, Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto (Japan); Hamada, Jun-ichiro [Kanazawa University, Department of Neurosurgery, Graduate School of Medical Sciences, Kanazawa (Japan)

    2007-05-15

    Cellulose porous beads (CPBs) are exceptionally uniform in size and nonabsorbable and they provide highly effective tumor devascularization. The risk of cranial nerve palsy must not be overlooked when embolization with CPBs is considered in meningioma patients. We attempted to identify patients at risk of cranial nerve palsy after meningioma embolization. Prior to preoperative superselective embolization with 200 {mu}m diameter CPBs, 141 patients with meningioma underwent provocation test with lidocaine and amytal. They were divided into two groups on the basis of whether they were or were not considered eligible for embolization. We evaluated the differences between the two groups with respect to tumor anatomy, angiographic findings, and clinical presentation and recorded complications associated with the embolization of the meningioma. Of the 141 patients, 128 underwent CPB embolization (group 2); 13 were not embolized because their provocation test results were positive (group 1, n = 11) or because they showed vasospasm (n = 2). Group 1 patients had meningioma in the cavernous sinus or petroclival region. Characteristically, the feeders were of middle meningeal artery origin and exhibited a posteromedial course toward the petrous apex or cavernous sinus. In group 2 patients the middle meningeal artery was the feeder, but it lacked branches coursing posteromedially. Three of these patients experienced complications which included intratumoral hemorrhage (n = 2) and post-embolization hearing disturbance (n = 1). Patients with meningioma whose tumor-feeding arteries run posteromedially toward the petrous apex or cavernous sinus are at increased risk of post-embolization cranial nerve palsy. Appropriate protocols, including lidocaine and amytal provocation tests, may reduce the risk of complications after CPB embolization of the external carotid territory in this group of patients. (orig.)

  2. Contextual representations of negative images modulate intrusion frequency in an intrusion provocation paradigm.

    Science.gov (United States)

    Krans, J; Pearson, D G; Maier, B; Moulds, M L

    2016-12-01

    To understand how memories of negative events become highly accessible in the context of trauma, we tested the hypothesis that contextual information modulates how easily intrusions can be provoked by perceptual stimuli.. Healthy participants viewed pictures depicting trauma scenes either with or without accompanying moderate (i.e. survival, recovery) or severe (i.e. fatality, permanent injury) outcome information. All participants viewed the same depictions of trauma scenes. Involuntary memories for the pictures were assessed using self-report diaries and an adapted version of the Impact of Event Scales (IES). A blurred picture perceptual priming paradigm was adapted to be used as an intrusion provocation task. The severe outcome group experienced a significantly higher frequency of intrusions on the intrusion provocation task in comparison to both moderate outcome and control (no-context) conditions. The severe outcome condition did not increase intrusions on the self-report diaries or the adapted IES. There was no effect of condition on ratings for the emotionality, self-relevance, valence, or seriousness of the trauma scenes. The analogue method should not be generalized directly to incidences of real-life trauma. It was unclear why differences in intrusion frequency were found in the provocation task only. The relative amount of individual conceptual and data-driven processing adopted by the participants was not assessed. Manipulating contextual information that determines the meaning of sensory-perceptual features for a trauma scene can modulate subsequent intrusion frequency in response to visually similar cues. Copyright © 2015 Elsevier Ltd. All rights reserved.

  3. North Korea’s Choice of the Types of Provocation Against South Korea

    Science.gov (United States)

    2013-12-01

    System En Coree Du Nord (Paris: L’HarmaHan, 1997), 86–135. Ibid., Bong-hwa Jeong, North Korean Policy toward South Korea, 110–111. 30 Bong-hwa Jeong...consequence of behaviors (one’s own or those of one’s opponent) that cause a crisis in a stable condition. This event threatens core values of...the core process required prior to all of these studies is to verify whether there have been noteworthy similarities in the provocations within

  4. Evaluation of Perfusion and Thermal Parameters of Skin Tissue Using Cold Provocation and Thermographic Measurements

    Directory of Open Access Journals (Sweden)

    Strąkowska Maria

    2016-09-01

    Full Text Available Measurement of the perfusion coefficient and thermal parameters of skin tissue using dynamic thermography is presented in this paper. A novel approach based on cold provocation and thermal modelling of skin tissue is presented. The measurement was performed on a person’s forearm using a special cooling device equipped with the Peltier module. The proposed method first cools the skin, and then measures the changes of its temperature matching the measurement results with a heat transfer model to estimate the skin perfusion and other thermal parameters. In order to assess correctness of the proposed approach, the uncertainty analysis was performed.

  5. Identifying Quantum Structures in the Ellsberg Paradox

    CERN Document Server

    Aerts, Diederik; Tapia, Jocelyn

    2013-01-01

    Empirical evidence has confirmed that quantum effects systematically occur also outside the microscopic domain, while quantum structures satisfactorily model various situations in several areas of science, including biological, cognitive and social processes. In this paper, we elaborate a quantum mechanical model which faithfully describes the 'Ellsberg paradox' in economics, showing that the mathematical formalism of quantum mechanics is capable to represent the 'ambiguity' present in this kind of situations, because of their 'contextuality'. Then, we analyze the data collected in a concrete experiment we performed on the Ellsberg paradox and work out a complete representation of them in complex Hilbert space, indicating that genuine quantum effects occur in the decision processes of the participants in the experiment. Our approach sheds light on 'ambiguity laden' decision processes in economics and decision theory, and allows to deal with different Ellsberg-type generalizations, e.g., the 'Machina paradox'.

  6. Nietzsche et les paradoxes de la force

    Directory of Open Access Journals (Sweden)

    Arnaud François

    2011-06-01

    Full Text Available According to this paper, the Nietzschean notion of force actually consists of a number of paradoxes, which I seek to formulate through the philosophical problems they pose. These paradoxes revolve around this fundamental paradox: on the one hand, force is able to rise and fall, but precisely how could such an increase and such a decrease be designed, as far as only what is given once for all can accept quantitative determinations? I come to draw two methods to answer this question (contrariety between two positive forces, reactivity of one force against the other, which suggest two ways of posing the biological and medical problems today, related to the notions of health and disease, in the scope of which Nietzsche has encountered it.

  7. Twin paradox on the photon sphere

    Science.gov (United States)

    Abramowicz, Marek A.; Bajtlik, Stanisław; Kluźniak, Włodek

    2007-04-01

    We consider another version of the twin paradox. The twins move along the same circular free photon path around the Schwarzschild center. In this case, despite their different velocities, all twins have the same nonzero acceleration. On the circular photon path, the symmetry between the twins situations is broken not by acceleration (as it is in the case of the classic twin paradox), but by the existence of an absolute standard of rest (timelike Killing vector). The twin with the higher velocity with respect to the standard of rest is younger on reunion. This closely resembles the case of periodic motions in compact (nontrivial topology) three-dimensional (3D) space recently considered in the context of the twin paradox by Barrow and Levin [Phys. Rev. A 63, 044104 (2001)], except that in that paper accelerations of all twins were equal to zero and that, in the case considered here, the 3D space has trivial topology.

  8. The Lindley paradox in optical interferometry

    Energy Technology Data Exchange (ETDEWEB)

    Mauri, Camillo [Quantum Technology Lab, Dipartimento di Fisica, Università degli Studi di Milano, I-20133 Milano (Italy); Paris, Matteo G.A., E-mail: matteo.paris@fisica.unimi.it [Quantum Technology Lab, Dipartimento di Fisica, Università degli Studi di Milano, I-20133 Milano (Italy); CNISM, Unità Milano Statale, I-20133 Milano (Italy); INFN, Sezione di Milano, I-20133 Milano (Italy)

    2016-02-05

    The so-called Lindley paradox is a counterintuitive statistical effect where the Bayesian and frequentist approaches to hypothesis testing give radically different answers, depending on the choice of the prior distribution. In this paper we address the occurrence of the Lindley paradox in optical interferometry and discuss its implications for high-precision measurements. In particular, we focus on phase estimation by Mach–Zehnder interferometers and show how to mitigate the conflict between the two approaches by using suitable priors. - Highlights: • We address the occurence of Lindley paradox in interferometry and discuss its implications for high-precision measurements. • We show how to mitigate the conflict between Bayesian and frequentist approach to interferometry using suitable priors. • Our results apply to calibration of homodyne detectors for quantum tomography.

  9. Can migraine aura be provoked experimentally? A systematic review of potential methods for the provocation of migraine aura.

    Science.gov (United States)

    Lindblad, Marianne; Hougaard, Anders; Amin, Faisal Mohammad; Ashina, Messoud

    2017-01-01

    Background The nature of the migraine aura and its role in migraine pathophysiology is incompletely understood. In particular, the mechanisms underlying aura initiation and the causal relation between aura and headache are unknown. The scientific investigation of aura in patients is only possible if aura can be triggered. This paper reviews potential methods for the experimental provocation of migraine aura. Methods We systematically searched PubMed for studies of experimental migraine provocation, including case reports of patients with aura and reports of the occurrence of aura following exposure to any kind of suspected trigger. Results We identified 21 provocation studies, using 13 different prospective provocation methods, and 34 case reports. In the prospective studies, aura were reported following the administration of intravenous and sublingual glyceryl trinitrate, visual stimulation, physical activity, calcitonin gene-related peptide infusion, chocolate ingestion, and the intravenous injection of insulin. In addition, carotid artery puncture has consistently been reported as a trigger of aura. Conclusions No safe and efficient method for aura provocation exists at present, but several approaches could prove useful for this purpose.

  10. Aggression in Children with Conduct Problems and Callous-Unemotional Traits: Social Information Processing and Response to Peer Provocation.

    Science.gov (United States)

    Helseth, Sarah A; Waschbusch, Daniel A; King, Sara; Willoughby, Michael T

    2015-11-01

    Callous/unemotional traits (CU) moderate children's conduct problems (CP) in numerous domains, including social functioning. The present study examined whether CU traits also moderate the aggressiveness of children's social information processing (SIP) and responses to varying intensities of peer provocation. Sixty elementary school-age children (46 males) were grouped into those without CP or CU (controls, n = 32), those with CP but not CU (CP-only; n = 14), and those with both CP and CU (CPCU, n = 14). Participants completed a task that measured two aspects of SIP (response generation and hostile attribution bias) and a computerized reaction time task (CRTT) that measured behavior, affect, and communication before and after provocation under instrumental and hostile aggressive conditions. Children with CPCU generated more aggressive responses than controls on measures of SIP. On the CRTT, all children exhibited reactive aggression following high provocation, but only children with CPCU exhibited proactive aggression, and reactive aggression following low provocation; no differences in affect were found. In a series of exploratory analyses, CPCU children communicated antisocially, while CP-only communicated prosocially. Finally, children with CPCU did not seem to hold a grudge following the final instance of provocation, instead gradually returning to baseline like their non-CU peers. These distinct social cognitive and behavioral profiles hint at different etiologies of CP and CPCU, underscoring the variability of aggression in these populations.

  11. The Paradox of Two Charged Capacitors

    CERN Document Server

    Singal, Ashok K

    2013-01-01

    It is shown that the famous paradox of two charged capacitors is successfully resolved if one properly considers all the energy changes in the system when some of the charges are transferred from one capacitor to the other. It happens so even when the connecting wire has an identically zero resistance, giving rise to no Ohmic losses in the wire. It is shown that in such a case the "missing energy" goes into the kinetic energy of conducting charges. It is shown that radiation plays no significant role in resolving the paradox. The problem can also be formulated and successfully resolved in an alternate form, without involving connecting wires in a circuit.

  12. The Myth of the Twin Paradox

    CERN Document Server

    Fischer, E

    2010-01-01

    One of the most discussed peculiarities of Einstein's theory of relativity is the twin paradox, the fact that the time between two events in space-time appears to depend on the path between these events. We show that this time discrepancy results only from faulty assumptions in the transition from one reference system to another. The twin paradox does not exist. But the Lorentz invariance of the theory has strong consequences, if we assume that it is valid not only locally, but also on cosmic scale.

  13. Assessment of heat provocation tests on the human gingiva: the effect of periodontal disease and smoking.

    Science.gov (United States)

    Molnár, E; Lohinai, Z; Demeter, A; Mikecs, B; Tóth, Z; Vág, János

    2015-06-01

    Periodontal inflammation is associated with morphological changes in the blood vessels which may influence the regulation of gingival blood flow (GBF). Our aim was to adapt the heat provocation test to the human gingiva to assess vascular reactivity in periodontal inflammation. GBF was recorded by Laser Doppler Flowmetry before and after heat provocation in healthy volunteers (n = 50). Heat was generated either by warm saline or a halogen lamp. The latter method was also utilized for a heat test in non-smoking and smoking patients with periodontal inflammation. The circulatory parameters were correlated to the inflammatory marker, i.e. gingival crevicular fluid (GCF) production measured by Periotron. Local application of heat caused a rapid, significant and transient increase in GBF regardless of the method used. The increase in the speed and not in the concentration of moving blood cells was responsible for increased GBF. Higher GCF values were correlated with increased peak flow, flux pulse amplitude and faster restoration of GBF after the test in non-smokers, but not in smokers. The heat test could be a valuable tool to check the vascular reactivity of gingival vessels. Moderate periodontal inflammation may facilitate gingival vascular responsiveness which can be suppressed by smoking.

  14. Scopolamine provocation-based pharmacological MRI model for testing procognitive agents.

    Science.gov (United States)

    Hegedűs, Nikolett; Laszy, Judit; Gyertyán, István; Kocsis, Pál; Gajári, Dávid; Dávid, Szabolcs; Deli, Levente; Pozsgay, Zsófia; Tihanyi, Károly

    2015-04-01

    There is a huge unmet need to understand and treat pathological cognitive impairment. The development of disease modifying cognitive enhancers is hindered by the lack of correct pathomechanism and suitable animal models. Most animal models to study cognition and pathology do not fulfil either the predictive validity, face validity or construct validity criteria, and also outcome measures greatly differ from those of human trials. Fortunately, some pharmacological agents such as scopolamine evoke similar effects on cognition and cerebral circulation in rodents and humans and functional MRI enables us to compare cognitive agents directly in different species. In this paper we report the validation of a scopolamine based rodent pharmacological MRI provocation model. The effects of deemed procognitive agents (donepezil, vinpocetine, piracetam, alpha 7 selective cholinergic compounds EVP-6124, PNU-120596) were compared on the blood-oxygen-level dependent responses and also linked to rodent cognitive models. These drugs revealed significant effect on scopolamine induced blood-oxygen-level dependent change except for piracetam. In the water labyrinth test only PNU-120596 did not show a significant effect. This provocational model is suitable for testing procognitive compounds. These functional MR imaging experiments can be paralleled with human studies, which may help reduce the number of false cognitive clinical trials. © The Author(s) 2015.

  15. Experimental provocation of 'ice-cream headache' by ice cubes and ice water.

    Science.gov (United States)

    Mages, Stephan; Hensel, Ole; Zierz, Antonia Maria; Kraya, Torsten; Zierz, Stephan

    2017-04-01

    Background There are various studies on experimentally provoked 'ice-cream headache' or 'headache attributed to ingestion or inhalation of a cold stimulus' (HICS) using different provocation protocols. The aim of this study was to compare two provocation protocols. Methods Ice cubes pressed to the palate and fast ingestion of ice water were used to provoke HICS and clinical features were compared. Results The ice-water stimulus provoked HICS significantly more often than the ice-cube stimulus (9/77 vs. 39/77). Ice-water-provoked HICS had a significantly shorter latency (median 15 s, range 4-97 s vs. median 68 s, range 27-96 s). There was no difference in pain localisation. Character after ice-cube stimulation was predominantly described as pressing and after ice-water stimulation as stabbing. A second HICS followed in 10/39 (26%) of the headaches provoked by ice water. Lacrimation occurred significantly more often in volunteers with than in those without HICS. Discussion HICS provoked by ice water was more frequent, had a shorter latency, different pain character and higher pain intensity than HICS provoked by ice cubes. The finding of two subsequent HICS attacks in the same volunteers supports the notion that two types of HICS exist. Lacrimation during HICS indicates involvement of the trigeminal-autonomic reflex.

  16. The evaluation of drug provocation tests in pediatric allergy clinic: a single center experience.

    Science.gov (United States)

    Vezir, Emine; Erkocoglu, Mustafa; Civelek, Ersoy; Kaya, Aysenur; Azkur, Dilek; Akan, Aysegül; Ozcan, Celal; Toyran, Muge; Ginis, Tayfur; Misirlioglu, Emine Dibek; Kocabas, Can Naci

    2014-01-01

    Drug provocation tests (DPTs) are gold standard to diagnose drug allergy. Our goal was to evaluate the results and safety of diagnostic methods including DPTs during childhood. Between January 2010 and February 2013 DPTs were performed and evaluated, prospectively, in children who attended our pediatric allergy clinic with a suspected drug hypersensitivity reaction. One hundred ninety-eight suspected drug reactions in 175 patients (88 boys and 87 girls) were evaluated. The median age of the subjects at the time of the suspected drug-induced hypersensitivity reaction and at the time of the study was 56 (interquartile range [IQR] = 24-120 months) months and 76 (IQR = 35-149 months) months, respectively. Suspected drugs were beta-lactam antibiotics in 108 cases (54.5%), non-beta-lactam antibiotics in 22 cases (11.1%), and nonsteroid anti-inflammatory drugs in 52 cases (26.3%). The history was compatible with immediate-type reactions in 69 cases (34.8%). Skin-prick tests were not positive in any of the cases. Intradermal tests were positive in three cases (4%). DPTs were positive in 13 (6.8%) of 191 provocation cases, which were performed with culprit drugs. Our results suggest that a positive clinical history is not enough to make a diagnosis of drug allergy, which highlights the significance of undertaking further diagnostic evaluation especially for DPTs.

  17. Pacifists and Revenge-Seekers in Response to Unambiguous Peer Provocation.

    Science.gov (United States)

    McDonald, Kristina L; Asher, Steven R

    2018-01-19

    In order to better understand why some children retaliate when they feel provoked and others do not, the present study identified "pacifistically-oriented" children who made negative interpretations in response to unambiguous provocations, yet did not endorse revenge goals, and compared them to "revenge-seeking" children who also made negative interpretations but did endorse revenge goals. Groups were identified based on seventh graders' (N = 367; 54.77% male; 22.89% racial/ethnic minority) responses to hypothetical situations in which a peer excluded and insulted them. Comparing these groups revealed that Pacifists endorsed relationship-maintaining goals and emotion regulation goals more highly than Revenge-Seekers. Revenge-Seekers reported more anger and endorsed beliefs about negative reciprocity and aggression being legitimate more highly than Pacifists. Additionally, Revenge-Seekers were more disrespect sensitive than were Pacifists, based on a measure of vigilance for signs of disrespect and expectations that others would disrespect them. Together these findings point to social-cognitive and emotion-related processes that may inhibit revenge-seeking in unambiguous provocation situations, even when children interpret the peer's behavior quite negatively.

  18. Amygdala hyperactivation during symptom provocation in obsessive–compulsive disorder and its modulation by distraction

    Directory of Open Access Journals (Sweden)

    Daniela Simon

    2014-01-01

    Full Text Available Anxiety disorders have been linked to a hyperactivated cortico-amygdalar circuitry. Recent findings highlight the amygdala's role in mediating elevated anxiety in obsessive–compulsive disorder (OCD. However, modulation of amygdala hyperactivation by attentional distraction – an effective emotion regulation strategy in healthy individuals – has not yet been examined. While undergoing functional magnetic resonance imaging twenty-one unmedicated OCD patients and 21 controls performed an evaluation and a distraction task during symptom provocation with individually tailored OCD-relevant pictures. To test the specificity of responses, additional aversive and neutral stimuli were included. Significant group-by-picture type interactions were observed within fronto–striato–limbic circuits including the amygdala. In these regions patients showed increased BOLD responses during processing of OCD triggers relative to healthy controls. Amygdala hyperactivation was present across OCD symptom dimensions indicating that it represents a common neural correlate. During distraction, we observed dampening of patients' amygdala hyperactivity to OCD-relevant stimuli. Augmented amygdala involvement in patients during symptom provocation, present across OCD symptom dimensions, might constitute a correlate of fear expression in OCD linking it to other anxiety disorders. Attentional distraction seemed to dampen emotional processing of disorder-relevant stimuli via amygdala downregulation. The clinical impact of this strategy to manage anxiety in OCD should be further elucidated.

  19. Reversal of a Suspected Paradoxical Reaction to Zopiclone with Flumazenil

    DEFF Research Database (Denmark)

    Jordahn, Zarah; Andersen, Cheme; Aaberg, Anne Marie Roust

    2016-01-01

    ), the patient became agitated and was confused, a possible paradoxical reaction to benzodiazepines. These symptoms were immediately resolved after treatment with flumazenil, usually used to reverse the adverse effects of benzodiazepines or NBRAs and to reverse paradoxical reactions to benzodiazepines. This case...... indicates that zopiclone induced behavioral changes resembling a paradoxical reaction to benzodiazepines and these symptoms may be treated with flumazenil....

  20. Habituated Reason: Aristotle and the "Paradox of Moral Education"

    Science.gov (United States)

    Kristjansson, Kristjan

    2006-01-01

    R.S. Peters coined the term "paradox of moral education". In this article, the author identifies two subordinate paradoxes: how habituated reason is psychologically possible and how heteronomously formed autonomy is morally/politically possible and justifiable. He sketches possible Aristotelian solutions of those paradoxes and argues that for…

  1. Paradoxical Interventions: A Review of the Recent Literature.

    Science.gov (United States)

    DeBord, Jeffrey B.

    1989-01-01

    Critically reviews clinical outcome literature on efficacy of paradoxical interventions in psychotherapy over last seven years. Examines studies under headings of paradoxical intention studies, symptom prescription studies, and reframing studies. Concludes with general evaluation of current standing of paradoxical interventions and calls for…

  2. Centromere Emergence in Evolution

    OpenAIRE

    Ventura, Mario; Archidiacono, Nicoletta; Rocchi, Mariano

    2001-01-01

    Evolutionary centromere repositioning is a paradox we have recently discovered while studying the conservation of the phylogenetic chromosome IX in primates. Two explanations were proposed: a conservative hypothesis assuming sequential pericentric inversions, and a more challenging assumption involving centromere emergence during evolution. The complex evolutionary history showed by chromosome IX did not allow us to clearly distinguish between these two hypotheses. Here we report comparative ...

  3. Micro-Macro Paradoxes of Entrepreneurship

    DEFF Research Database (Denmark)

    Søgaard, Villy

    2008-01-01

    Artiklen tager afsæt i det såkaldte micro-macro paradox fra Aids-Efficiency litteraturen og argumenterer for, at en tilsvarende problemstilling bør inddrages i vurderingen af f.eks. de beskæftigelsesmæssige konsekvenser af entrepreneuriel virksomhed. Den påviser også i en gennemgang af litteratur...

  4. Art's Pedagogical Paradox

    Science.gov (United States)

    Kalin, Nadine M.

    2014-01-01

    This article contributes to conversations concerning art education futures through engaging alternative relations between art, education, and democracy that mobilize education as art projects associated with the "pedagogical turn" as sites of liminality and paradox. An analysis of the art project, Pedagogical Factory, is used to outline…

  5. Quantum Zeno and anti-Zeno paradoxes

    Indian Academy of Sciences (India)

    Continuous observation of a time independent projection operator is known to prevent change of state (the quantum Zeno paradox). We discuss the recent result that ... Author Affiliations. S M Roy1. Department of Theoretical Physics, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400 005, India ...

  6. Sustainable Development: Paradoxes, Misunderstandings and Learning Organizations

    Science.gov (United States)

    Ramirez, Gabriel A.

    2012-01-01

    Purpose: Sustainability is, in itself, the idea of a harmonic answer to the dual nature of the most pressing problem for global society. Most of the problems dealing with sustainability concern its dual and contradictory nature. That paradoxical reality is in no way a unique feature of sustainability; its universal pervasiveness is demonstrated by…

  7. Motivation in Beyond Budgeting: A Motivational Paradox?

    DEFF Research Database (Denmark)

    Sandalgaard, Niels; Bukh, Per Nikolaj

    In this paper we discuss the role of motivation in relation to budgeting and we analyse how the Beyond Budgeting model functions compared with traditional budgeting. In the paper we focus on budget related motivation (and motivation in general) and conclude that the Beyond Budgeting model...... is a motivational paradox....

  8. Paradoxes of leadership: contingencies and critical learning

    African Journals Online (AJOL)

    Erna Kinsey

    There is a deep puzzle, or paradox, at the core of leadership studies, both in education and beyond .... instead try to explain their role in other terms. He proposed ... certain distance from its nearest flockmates. Second, the ..... culture of teacher autonomy and professionalism, and resulting high levels of student learning ...

  9. Amphetamine's Paradoxical Effects May Be Predictable

    Science.gov (United States)

    Zentall, Sydney S.; Zentall, Thomas R.

    1976-01-01

    It is suggested that the so-called paradoxical calming or depressant effects of amphetamine on hyperactive children can be accounted for by the proposition that amphetamines increase arousal when the initial arousal level is low but decrease arousal when the initial level is high. (Author)

  10. A Paradox in Radiation Heat Transfer

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 12; Issue 4. A Paradox in Radiation Heat Transfer. J Srinivasan. Classroom Volume 12 Issue 4 April 2007 pp 85-91. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/012/04/0085-0091. Keywords. Radiation ...

  11. Calcium paradox and calcium entry blockers

    NARCIS (Netherlands)

    Ruigrok, T.J.C.; Slade, A.M.; Nayler, W.G.; Meijler, F.L.

    1984-01-01

    Reperfusion of isolated hearts with calcium-containing solution after a short period of calcium-free perfusion results in irreversible cell damage (calcium paradox). This phenomenon is characterized by an excessive influx of calcium into the cells, the rapid onset of myocardial contracture,

  12. The Performance Paradox in the Public Sector

    NARCIS (Netherlands)

    S. van Thiel (Sandra); F.L. Leeuw

    2002-01-01

    textabstractAdministrative reform has led to a strong increase in the use of performance assessment instruments in the public sector. However, this has also led to several unintended consequences, such as the performance paradox, tunnel vision and ‘analysis paralysis’. These unintended consequences

  13. Joblessness in the Arctic: The Alaskan Paradox.

    Science.gov (United States)

    Bland, Laurel L.

    Alaska is in the paradoxical position of having more jobs available than people, and at the same time maintaining one of the highest unemployment rates in the nation. This report discusses the nature and skills of the unemployed and underemployed, and presents tables of demographic information. While a fair percentage of Alaskan native youth…

  14. Secure communication in the twin paradox

    CERN Document Server

    Garcia-Escartin, Juan Carlos

    2010-01-01

    The channel capacity between two users is affected by relativistic effects. Under the presence of a fixed noise at the receiver, there appears an asymmetry between "slowly aging" and "fast aging" observers which can be used to have private communication transmission. We discuss some models for users inside gravitational wells and in the twin paradox scenario.

  15. On the Ingredients of the Twin Paradox

    Science.gov (United States)

    Grandou, T.; Rubin, J. L.

    2009-01-01

    If M is a 4-dimensional connected, orientable flat spacetime manifold endowed with a time-arrow, and if the existence of a finite speed limit to energy/information transfers over M can be assessed, then the “twin paradox” necessarily follows (and indeed, the full special relativity theory). Two other implicit ingredients of the paradox are also identified.

  16. Twin Paradox in de Sitter Spacetime

    Science.gov (United States)

    Boblest, Sebastian; Muller, Thomas; Wunner, Gunter

    2011-01-01

    The "twin paradox" of special relativity offers the possibility of making interstellar flights within a lifetime. For very long journeys with velocities close to the speed of light, however, we have to take into account the expansion of the universe. Inspired by the work of Rindler on hyperbolic motion in curved spacetime, we study the worldline…

  17. Secure Communication in the Twin Paradox

    Science.gov (United States)

    Garcia-Escartin, Juan Carlos; Chamorro-Posada, Pedro

    2015-11-01

    The amount of information that can be transmitted through a noisy channel is affected by relativistic effects. Under the presence of a fixed noise at the receiver, there appears an asymmetry between "slowly aging" and "fast aging" observers which can be used to have private information transmission. We discuss some models for users inside gravitational wells and in the twin paradox scenario.

  18. The EPR Paradox: Einstein Scrutinises Quantum Mechanics

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 5; Issue 4. The EPR Paradox: Einstein Scrutinises Quantum Mechanics. Arvind. General Article Volume 5 Issue 4 April 2000 pp 28-36. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/005/04/0028-0036 ...

  19. The Discursive Dilemma as a Lottery Paradox

    NARCIS (Netherlands)

    Douven, I.; Romeyn, J.-W.

    2006-01-01

    List and Pettit have stated an impossibility theorem about the aggregation of individual opinion states. Building on recent work on the lottery paradox, this paper offers a variation on that result. The present result places different constraints on the voting agenda and the domain of profiles, but

  20. FINANCING TERRORISM: FROM OFFSHORE COMPANIES TO THE CHARITY PARADOX

    Directory of Open Access Journals (Sweden)

    Irina IONESCU

    2015-06-01

    Full Text Available The world is currently living to its edges, menaced at each corner by environmental changes, terrorist attacks, civil wars or biological weapons let loose. With the emerging of the Islamic State and other terrorist cells the entire world under the peaceful globalization sphere questions its security. The paper aims to focus on detailing the most modern ways of financing terrorism, including through tax haven offshore companies, and the charity paradox. Charity institutions, several banks and even Non-Profit Organizations go hand in hand with a full range of felonies, from money laundering to narcotic traffic, humans trafficking, organized crime, arms dealing and terrorist attacks. The paper aims to offer pertinent solutions to tax havens and light legislation in order to prevent terrorist groups and cells from becoming an extensively rich and potent menace to global and state security.

  1. Paradoxical hypomagnesemia caused by excessive ingestion of magnesium hydroxide.

    Science.gov (United States)

    Joo Suk, Oh

    2008-09-01

    Excessive ingestion of magnesium may lead to hypermagnesemia even without kidney dysfunction. Several cases of development of hypermagnesemia after overdose of magnesium hydroxide have been reported. Although magnesium hydroxide is widely used as laxative, its overdose may induce diarrhea, which is followed by excessive magnesium loss. I report a case of paradoxical hypomagnesemia developed after excessive ingestion of magnesium hydroxide. A 39-year-old woman was presented to the emergency department complaining of severe watery diarrhea and carpopedal spasm after ingesting a handful of magnesium hydroxide tablets. The laboratory tests detected hypomagnesemia, hypocalcemia, and normokalemia. Calcium gluconate was given to the patient, but her symptom did not improve shortly. The symptom disappeared spontaneously 2 days after the watery diarrhea subsided. This case shows that overdose of magnesium hydroxide, which leads to massive diarrhea, might induce hypomagnesemia unexpectedly. This case also suggests that it should be treated, as well as typical magnesium deficiency.

  2. Does evaporation paradox exist in China?

    Directory of Open Access Journals (Sweden)

    Z. T. Cong

    2009-03-01

    Full Text Available One expected consequence of global warming is the increase in evaporation. However, lots of observations show that the rate of evaporation from open pans of water has been steadily decreasing all over the world in the past 50 years. The contrast between expectation and observation is called "evaporation paradox". Based on data from 317 weather stations in China from 1956 to 2005, the trends of pan evaporation and air temperature were obtained and evaporation paradox was analyzed. The conclusions include: (1 From 1956 to 2005, pan evaporation paradox existed in China as a whole while pan evaporation kept decreasing and air temperature became warmer and warmer, but it does not apply to Northeast and Southeast China; (2 From 1956 to 1985, pan evaporation paradox existed narrowly as a whole with unobvious climate warming trend, but it does not apply to Northeast China; (3 From 1986 to 2005, in the past 20 years, pan evaporation paradox did not exist for the whole period while pan evaporation kept increasing, although it existed in South China. Furthermore, the trend of other weather factors including sunshine duration, windspeed, humidity and vapor pressure deficit, and their relations with pan evaporation are discussed. As a result, it can be concluded that pan evaporation decreasing is caused by the decreasing in radiation and wind speed before 1985 and pan evaporation increasing is caused by the decreasing in vapor pressure deficit due to strong warming after 1986. With the Budyko curve, it can be concluded that the actual evaporation decreased in the former 30 years and increased in the latter 20 year for the whole China.

  3. Distributed Leadership and the Visibility/Invisibility Paradox in On-line Communities

    OpenAIRE

    Jill Jameson

    2011-01-01

    This paper analyzes the role of distributed leadership in three on-line communities, reflecting on an observed visibility/invisibility paradox in leadership within these communities. Leaders who downplay their seniority and assume a degree of invisibility, allocating discretionary powers to subordinate levels in an organizational hierarchy, may facilitate the emergence of distributed leadership. Yet, simultaneously, leader-led relations are enabled by high leadership visibility. This paradox—...

  4. Climate paradox of the G-8: legal obligations, policy declarations and implementation gap

    Directory of Open Access Journals (Sweden)

    Hans Guenter Brauch

    2012-01-01

    Full Text Available This article analyzes the climate policy performance of the G-8 from 1992 to 2012 based on their legal commitments (Annex-1 and Annex-B countries under the UNFCCC (1992 and the Kyoto Protocol (1997 and their policy declarations on their GHG reduction goals until 2050. A climate paradox has emerged due to a growing implementation gap in Canada, USA and Japan, while Russia, Germany, UK, France and Italy fulfilled their GHG reduction obligation.

  5. Challenges and Paradoxes of Human Factors in Health Technology Design.

    Science.gov (United States)

    Morita, Plinio P; Cafazzo, Joseph A

    2016-03-01

    Usability testing allows human factors professionals to identify and mitigate issues with the design and use of medical technology. The test results, however, can be paradoxical and therefore be misinterpreted, limiting their usefulness. The paradoxical findings can lead to products that are not aligned with the needs and constraints of their users. We herein report on our observations of the paradox of expertise, the paradox of preference versus performance, and the paradox of choice. Each paradox explored is in the perspective of the design of medical technology, the issues that need to be considered in the interpretation of the test results, as well as suggestions on how to avoid the pitfalls in the design of medical technology. Because these paradoxes can influence product design at various stages of product development, it is important to be aware of the effects to interpret the findings properly.

  6. THE ROLE OF STYLISTIC MEANS IN CREATING PARADOX

    Directory of Open Access Journals (Sweden)

    Marina Vladimirovna Lekova

    2017-03-01

    Full Text Available Purpose. Despite the existence of massive scientific literature devoted to paradox this phenomenon does not seem to have received sufficient linguistic coverage. The purpose of the article is to describe stylistic mechanisms underlying paradoxical statements. The investigation was carried out on the material collected from the fairy tales by O. Wilde, the distinguished master of paradoxes. Methodology. The investigation is based on the methods of stylistic identification, classification and description, as well as contextual analysis. Results. The article treats paradox not only as a logical, but also as a linguistic category. Among stylistic markers of paradoxes personification, hyperbole, irony, antithesis and contrast are analyzed. Attempts are made to prove that these stylistic devices are paradoxical by their nature. The article considers varieties of paradoxical statements spawned by each of them in the fairy tales by O. Wilde. Practical applications. The results of the investigation can be employed at lectures and practical classes in Theory of literature and English stylistics.

  7. Power and Provocativeness: The Effects of Subtle Changes in Clothing on Perceptions of Working Women.

    Science.gov (United States)

    Gurung, Regan A R; Punke, Elizabeth; Brickner, Michaella; Badalamenti, Vincenzio

    2017-05-19

    The current study investigates the effects of subtle changes in professional women's dress on women's perceptions of power and competence. We replicate and extend Howlett, Pine, Cahill, Orakcioglu, and Fletcher's (2015) research showing women in provocative clothing are rated as less competent. We used a larger sample, tested a second independent variable, and fine-tuned the design for higher face validity. Participants (N = 198, 170 women and 29 men) from a Midwestern university in the USA rated four photographs of professionally dressed women whose blouses varied in the number of buttons left undone and whether they wore a camisole. We found main effects of buttons (undone/done) and camisoles (on/off) for participants perceptions of intelligence, competence, powerfulness, and on a global rating score. Results also showed significant interaction effects between buttons and camisoles on ratings of powerfulness. The results have many implications for how women dress professionally.

  8. Validation of the Novaco Anger Scale-Provocation Inventory (Danish) With Nonclinical, Clinical, and Offender Samples

    DEFF Research Database (Denmark)

    Moeller, Stine Bjerrum; Novaco, Raymond; Heinola-Nielsen, Vivian

    2015-01-01

    . Because the Novaco Anger Scale and Provocation Inventory (NAS-PI) has been extensively validated with different clinical populations and lends itself to clinical case formulation, it was selected for translation and evaluation in the present multistudy project. Psychometric properties of the NAS-PI were...... investigated with samples of 477 nonclinical, 250 clinical, 167 male prisoner, and 64 male forensic participants. Anger prevalence and its relationship with other anger measures, anxiety/depression, and aggression were examined. NAS-PI was found to have high reliability, concurrent validity, and discriminant...... aggressive behavior in hospital. Regression analyses showed that higher scores on NAS increase the risk of having acted aggressively in the past and of acting aggressively in the future....

  9. Posterior midline activation during symptom provocation in acute stress disorder: An fMRI study

    Directory of Open Access Journals (Sweden)

    Jan Christopher Cwik

    2014-05-01

    Full Text Available Functional imaging studies of patients with Posttraumatic Stress Disorder showed wide-spread activation of mid-line cortical areas during symptom provocation i.e., exposure to trauma-related cues. The present study aimed at investigating neural activation during exposure to trauma-related pictures in patients with Acute Stress Disorder (ASD shortly after the traumatic event. Nineteen ASD patients and 19 healthy control participants were presented with individualized pictures of the traumatic event and emotionally neutral control pictures during the acquisition of whole-brain data with a 3-T fMRI scanner. Compared to the control group and to control pictures, ASD patients showed significant activation in mid-line cortical areas in response to trauma-related pictures including precuneus, cuneus, postcentral gyrus and pre-supplementary motor area. The results suggest that the trauma-related pictures evoke emotionally salient self-referential processing in ASD patients.

  10. Lorazepam provocation test in purported schizophrenia with lack of treatment response

    Directory of Open Access Journals (Sweden)

    John E. Berg

    2014-09-01

    Full Text Available Some patients with severe mental disorders are refractory to psychotherapeutic or psychopharmacological interventions. We present a patient who at the age of 19 developed several schizophrenia - suspect symptoms. Soon inexplicable general seizures where observed. He was treated with antipsychotics, but had two bouts of malignant neuroleptic syndrome. Electroconvulsive therapy (ECT gave some symptom relief and he continued on maintenance ECT for years with weekly intervals. Interruption of this treatment pattern rapidly increased symptom load. After seven years a lorazepam provocation test was performed as he had a new relapse after 3 weeks without ECT. In the ensuing hours his aggressiveness and nonsense speaking rapidly diminished. Kahlbaums observation of seizures as part of a catatonia was not understood in this case. The publication of the new DSM-V diagnosis of catatonia may hopefully reduce the probability of treating a patient for schizophrenia for years without access to a more targeted medication and ECT plan.

  11. Exercise as a provocative test in early renal disease in type 1 (insulin-dependent) diabetes

    DEFF Research Database (Denmark)

    Feldt-Rasmussen, B; Baker, L; Deckert, T

    1985-01-01

    The value of exercise as a provocative test for early renal disease in Type 1 (insulin-dependent) diabetes was re-evaluated. Three carefully characterized groups of males were studied: 10 non-diabetic controls, 16 diabetic patients (group 1) with normal urinary albumin excretion (less than 15...... micrograms/min) and 14 Albustix-negative diabetics (group 2) with increased urinary albumin excretion (15-122 micrograms/min). Assignment to a study group was made on the basis of three 24-h urine collections, and the groups were well matched for age, weight, height, and serum creatinine concentration....... The two diabetic groups were similar with regard to duration of disease (13 +/- 6 versus 16 +/- 3 years), metabolic control (HbA1c: 8.4 +/- 1.4 versus 8.7 +/- 1.3%) and degree of diabetic complications (beat-to-beat variation and retinopathy). An exercise protocol of 450 and 600 kpm/min workloads...

  12. Neural and Behavioral Correlates of Alcohol-Induced Aggression Under Provocation.

    Science.gov (United States)

    Gan, Gabriela; Sterzer, Philipp; Marxen, Michael; Zimmermann, Ulrich S; Smolka, Michael N

    2015-12-01

    Although alcohol consumption is linked to increased aggression, its neural correlates have not directly been studied in humans so far. Based on a comprehensive neurobiological model of alcohol-induced aggression, we hypothesized that alcohol-induced aggression would go along with increased amygdala and ventral striatum reactivity and impaired functioning of the prefrontal cortex (PFC) under alcohol. We measured neural and behavioral correlates of alcohol-induced aggression in a provoking vs non-provoking condition with a variant of the Taylor aggression paradigm (TAP) allowing to differentiate between reactive (provoked) and proactive (unprovoked) aggression. In a placebo-controlled cross-over design with moderate alcohol intoxication (~0.6 g/kg), 35 young healthy adults performed the TAP during functional magnetic resonance imaging (fMRI). Analyses revealed that provoking vs non-provoking conditions and alcohol vs placebo increased aggression and decreased brain responses in the anterior cingulate cortex/dorso-medial PFC (provokingalcoholalcohol specifically increased proactive (unprovoked) but not reactive (provoked) aggression (alcohol × provocation interaction). However, investigation of inter-individual differences revealed (1) that pronounced alcohol-induced proactive aggression was linked to higher levels of aggression under placebo, and (2) that pronounced alcohol-induced reactive aggression was related to increased amygdala and ventral striatum reactivity under alcohol, providing evidence for their role in human alcohol-induced reactive aggression. Our findings suggest that in healthy young adults a liability for alcohol-induced aggression in a non-provoking context might depend on overall high levels of aggression, but on alcohol-induced increased striatal and amygdala reactivity when triggered by provocation.

  13. Neural and Behavioral Correlates of Alcohol-Induced Aggression Under Provocation

    Science.gov (United States)

    Gan, Gabriela; Sterzer, Philipp; Marxen, Michael; Zimmermann, Ulrich S; Smolka, Michael N

    2015-01-01

    Although alcohol consumption is linked to increased aggression, its neural correlates have not directly been studied in humans so far. Based on a comprehensive neurobiological model of alcohol-induced aggression, we hypothesized that alcohol-induced aggression would go along with increased amygdala and ventral striatum reactivity and impaired functioning of the prefrontal cortex (PFC) under alcohol. We measured neural and behavioral correlates of alcohol-induced aggression in a provoking vs non-provoking condition with a variant of the Taylor aggression paradigm (TAP) allowing to differentiate between reactive (provoked) and proactive (unprovoked) aggression. In a placebo-controlled cross-over design with moderate alcohol intoxication (~0.6 g/kg), 35 young healthy adults performed the TAP during functional magnetic resonance imaging (fMRI). Analyses revealed that provoking vs non-provoking conditions and alcohol vs placebo increased aggression and decreased brain responses in the anterior cingulate cortex/dorso-medial PFC (provokingalcoholalcohol specifically increased proactive (unprovoked) but not reactive (provoked) aggression (alcohol × provocation interaction). However, investigation of inter-individual differences revealed (1) that pronounced alcohol-induced proactive aggression was linked to higher levels of aggression under placebo, and (2) that pronounced alcohol-induced reactive aggression was related to increased amygdala and ventral striatum reactivity under alcohol, providing evidence for their role in human alcohol-induced reactive aggression. Our findings suggest that in healthy young adults a liability for alcohol-induced aggression in a non-provoking context might depend on overall high levels of aggression, but on alcohol-induced increased striatal and amygdala reactivity when triggered by provocation. PMID:25971590

  14. Hypersensitivity to RF fields emitted from CDMA cellular phones: a provocation study.

    Science.gov (United States)

    Nam, Ki Chang; Lee, Ju Hyung; Noh, Hyung Wook; Cha, Eun Jong; Kim, Nam Hyun; Kim, Deok Won

    2009-12-01

    With the number of cellular phone users rapidly increasing, there is a considerable amount of public concern regarding the effects that electromagnetic fields (EMFs) from cellular phones have on health. People with self-attributed electromagnetic hypersensitivity (EHS) complain of subjective symptoms such as headaches, insomnia, and memory loss, and attribute these symptoms to radio frequency (RF) radiation from cellular phones and/or base stations. However, EHS is difficult to diagnose because it relies on a person's subjective judgment. Various provocation studies have been conducted on EHS caused by Global System for Mobile Communications (GSM) phones in which heart rate and blood pressure or subjective symptoms were investigated. However, there have been few sham-controlled provocation studies on EHS with Code Division Multiple Access (CDMA) phones where physiological parameters, subjective symptoms, and perception of RF radiation for EHS and non-EHS groups were simultaneously investigated. In this study, two volunteer groups of 18 self-reported EHS and 19 non-EHS persons were tested for both sham and real RF exposure from CDMA cellular phones with a 300 mW maximum exposure that lasted half an hour. We investigated not only the physiological parameters such as heart rate, respiration rate, and heart rate variability (HRV), but also various subjective symptoms and the perception of EMF. In conclusion, RF exposure did not have any effects on physiological parameters or subjective symptoms in either group. As for EMF perception, there was no evidence that the EHS group better perceived EMF than the non-EHS group.

  15. Individual Differences in Automatic Emotion Regulation Interact with Primed Emotion Regulation during an Anger Provocation

    Directory of Open Access Journals (Sweden)

    Ping Hu

    2017-04-01

    Full Text Available The current study investigated the interactive effects of individual differences in automatic emotion regulation (AER and primed emotion regulation strategy on skin conductance level (SCL and heart rate during provoked anger. The study was a 2 × 2 [AER tendency (expression vs. control × priming (expression vs. control] between subject design. Participants were assigned to two groups according to their performance on an emotion regulation-IAT (differentiating automatic emotion control tendency and automatic emotion expression tendency. Then participants of the two groups were randomly assigned to two emotion regulation priming conditions (emotion control priming or emotion expression priming. Anger was provoked by blaming participants for slow performance during a subsequent backward subtraction task. In anger provocation, SCL of individuals with automatic emotion control tendencies in the control priming condition was lower than of those with automatic emotion control tendencies in the expression priming condition. However, SCL of individuals with automatic emotion expression tendencies did no differ in the automatic emotion control priming or the automatic emotion expression priming condition. Heart rate during anger provocation was higher in individuals with automatic emotion expression tendencies than in individuals with automatic emotion control tendencies regardless of priming condition. This pattern indicates an interactive effect of individual differences in AER and emotion regulation priming on SCL, which is an index of emotional arousal. Heart rate was only sensitive to the individual differences in AER, and did not reflect this interaction. This finding has implications for clinical studies of the use of emotion regulation strategy training suggesting that different practices are optimal for individuals who differ in AER tendencies.

  16. Methacholine bronchial provocation measured by spirometry versus wheeze detection in preschool children

    Directory of Open Access Journals (Sweden)

    Yahav Yaacov

    2005-06-01

    Full Text Available Abstract Background Determination of PC20-FEV1 during Methacholine bronchial provocation test (MCT is considered to be impossible in preschool children, as it requires repetitive spirometry sets. The aim of this study was to assess the feasibility of determining PC20-FEV1 in preschool age children and compares the results to the wheeze detection (PCW method. Methods 55 preschool children (ages 2.8–6.4 years with recurrent respiratory symptoms were recruited. Baseline spirometry and MCT were performed according to ATS/ERS guidelines and the following parameters were determined at baseline and after each inhalation: spirometry-indices, lung auscultation at tidal breathing, oxygen saturation, respiratory and heart rate. Comparison between PCW and PC20-FEV1 and clinical parameters at these end-points was done by paired Student's t-tests. Results and discussion Thirty-six of 55 children (65.4% successfully performed spirometry-sets up to the point of PCW. PC20-FEV1 occurred at a mean concentration of 1.70+/-2.01 while PCW occurred at a mean concentration of 4.37+/-3.40 mg/ml (p 1 by 44.7+/-14.5%; PEFR by 40.5+/-14.5 and FEF25–75 by 54.7+/-14.4% (P Conclusion Determination of PC20-FEV1 by spirometry is feasible in many preschool children. PC20-FEV1 often appears at lower provocation dose than PCW. The lower dose may shorten the test and encourage participation. Significant decrease in spirometry indices at PCW suggests that PC20-FEV1 determination may be safer.

  17. Individual Differences in Automatic Emotion Regulation Interact with Primed Emotion Regulation during an Anger Provocation

    Science.gov (United States)

    Zhang, Jing; Lipp, Ottmar V.; Hu, Ping

    2017-01-01

    The current study investigated the interactive effects of individual differences in automatic emotion regulation (AER) and primed emotion regulation strategy on skin conductance level (SCL) and heart rate during provoked anger. The study was a 2 × 2 [AER tendency (expression vs. control) × priming (expression vs. control)] between subject design. Participants were assigned to two groups according to their performance on an emotion regulation-IAT (differentiating automatic emotion control tendency and automatic emotion expression tendency). Then participants of the two groups were randomly assigned to two emotion regulation priming conditions (emotion control priming or emotion expression priming). Anger was provoked by blaming participants for slow performance during a subsequent backward subtraction task. In anger provocation, SCL of individuals with automatic emotion control tendencies in the control priming condition was lower than of those with automatic emotion control tendencies in the expression priming condition. However, SCL of individuals with automatic emotion expression tendencies did no differ in the automatic emotion control priming or the automatic emotion expression priming condition. Heart rate during anger provocation was higher in individuals with automatic emotion expression tendencies than in individuals with automatic emotion control tendencies regardless of priming condition. This pattern indicates an interactive effect of individual differences in AER and emotion regulation priming on SCL, which is an index of emotional arousal. Heart rate was only sensitive to the individual differences in AER, and did not reflect this interaction. This finding has implications for clinical studies of the use of emotion regulation strategy training suggesting that different practices are optimal for individuals who differ in AER tendencies. PMID:28484412

  18. An Apparatus to Deliver Mannitol Powder for Bronchial Provocation in Children Under Six Years Old.

    Science.gov (United States)

    Tang, Patricia; Leung, Sharon S Y; Hor, Eleanor; Ruzycki, Conor A; Carrigy, Nicholas B; Finlay, Warren H; Brannan, John D; Devadason, Sunalene; Anderson, Sandra D; Sly, Peter D; Samnick, Kevin; Chan, Hak-Kim

    2015-12-01

    Currently bronchial provocation testing (BPT) using mannitol powder cannot be performed in children under 6 years. A primary reason is it is challenging for children at this age to generate a consistent inspiratory effort to inhale mannitol efficiently from a dry powder inhaler. A prototype system, which does not require any inhalation training from the pediatric subject, is reported here. It uses an external source of compressed air to disperse mannitol powder into a commercial holding chamber. Then the subject uses tidal breathing to inhale the aerosol. The setup consists of a commercially available powder disperser and Volumatic™ holding chamber. Taguchi experimental design was used to identify the effect of dispersion parameters (flow rate of compressed air, time compressed air is applied, mass of powder, and the time between dispersion and inhalation) on the fine particle dose (FPD). The prototype was tested in vitro using a USP throat connected to a next generation impactor. The aerosols from the holding chamber were drawn at 10 L/min. A scaling factor for estimating the provoking dose to induce a 15% reduction in forced expiratory volume in 1 second (FEV1) (PD15) was calculated using anatomical dimensions of the human respiratory tract at various ages combined with known dosing values from the adult BPT. Consistent and doubling FPDs were successfully generated based on the Taguchi experimental design. The FPD was reliable over a range of 0.8 (±0.09) mg to 14 (±0.94) mg. The calculated PD15 for children aged 1-6 years ranged from 7.1-30 mg. The FPDs generated from the proposed set up are lower than the calculated PD15 and therefore are not expected to cause sudden bronchoconstriction. A prototype aerosol delivery system has been developed that is consistently able to deliver doubling doses suitable for bronchial provocation testing in young children.

  19. MODELING PARADOXES IN NOVICE AND EXPERT DESIGN

    DEFF Research Database (Denmark)

    Dorst, Kees; Hansen, Claus Thorp

    2011-01-01

    In their ICED09 paper ‘Problem formulation as a discursive activity’, the authors have used an extensive educational case study to explore a framework for describing design as a discursive activity, centered around the paradoxical nature of the problem situation. The ‘working definition’ for para......In their ICED09 paper ‘Problem formulation as a discursive activity’, the authors have used an extensive educational case study to explore a framework for describing design as a discursive activity, centered around the paradoxical nature of the problem situation. The ‘working definition...... at play in a design situation, and extract themes that can lead to reformulation of the problem as well as the creation of innovative solutions. This behaviour is compared to the ways of working of novice designers (students) in the original case study....

  20. A Probabilistic Analysis of the Fermi Paradox

    CERN Document Server

    Solomonides, Evan; Terzian, Yervant

    2016-01-01

    The fermi paradox uses an appeal to the mediocrity principle to make it seem counter-intuitive that humanity has not been contacted by extraterrestrial intelligence. A numerical, statistical analysis was conducted to determine whether this apparent loneliness is, in fact, unexpected. An inequality was derived to relate the frequency of life arising and developing technology on a suitable planet in the galaxy, the average length of time since the first broadcast of such a civilization, and a constant term. An analysis of the sphere reached thus far by human communication was also conducted, considering our local neighborhood and planets of particular interest. We clearly show that human communication has not reached a number of stars and planets adequate to expect an answer. These analyses both conclude that the Fermi paradox is not, in fact, unexpected. By the mediocrity principle and numerical modeling, it is actually unlikely that the Earth would have been reached by extraterrestrial communication at this p...

  1. Treatment of erythrophobia by paradoxical intention.

    Science.gov (United States)

    Lamontagne, Y

    1978-04-01

    A 25-year-old male was treated by paradoxical intention for erythrophobia that had been present for 12 years. Severe blushing episodes decreased from 28 during the month preceding treatment to three during treatment; there were never more than two severe blushing episodes per month during the 6-month follow-up. The mean duration of each severe episode was 13 minutes before treatment, 8 minutes during treatment, and varied from 4 to 9 minutes during follow-up. Although this treatment is easy for both the patient and therapist, it is important that the patient be highly motivated. A good relationship with the therapist and the use of humor can enhance the therapeutic efficacy of paradoxical intention.

  2. A history of the Allais paradox.

    Science.gov (United States)

    Heukelom, Floris

    2015-03-01

    This article documents the history of the Allais paradox, and shows that underneath the many discussions of the various protagonists lay different, irreconcilable epistemological positions. Savage, like his mentor von Neumann and similar to economist Friedman, worked from an epistemology of generalized characterizations. Allais, on the other hand, like economists Samuelson and Baumol, started from an epistemology of exact descriptions in which every axiom was an empirical claim that could be refuted directly by observations. As a result, the two sides failed to find a common ground. Only a few decades later was the now so-called Allais paradox rediscovered as an important precursor when a new behavioural economic subdiscipline started to adopt the epistemology of exact descriptions and its accompanying falsifications of rational choice theory.

  3. Adaptationism fails to resolve Fermi's paradox

    Directory of Open Access Journals (Sweden)

    Ćirković Milan M.

    2005-01-01

    Full Text Available One of the most interesting problems in the nascent discipline of astrobiology is more than half-century old Fermi's paradox: why, considering extraordinary young age of Earth and the Solar System in the Galactic context, don't we perceive much older intelligent communities or signposts of their activity? In spite of a vigorous research activity in recent years, especially bolstered by successes of astrobiology in finding extrasolar planets and extremophiles, this problem (also known as the "Great Silence" or "astrosociological" paradox remains as open as ever. In a previous paper, we have discussed a particular evolutionary solution suggested by Karl Schroeder based on the currently dominant evolutionary doctrine of adaptationism. Here, we extend that discussion with emphasis on the problems such a solution is bound to face, and conclude that it is ultimately quite unlikely. .

  4. Feasibility of omitting provocation test with 50 μg of acetylcholine in left coronary artery.

    Science.gov (United States)

    Saito, Yuichi; Kitahara, Hideki; Shoji, Toshihiro; Tokimasa, Satoshi; Nakayama, Takashi; Sugimoto, Kazumasa; Fujimoto, Yoshihide; Kobayashi, Yoshio

    2017-06-01

    According to the Japanese Circulation Society guideline of vasospastic angina, incremental doses of acetylcholine (ACh) are prescribed for coronary spasm provocation: 20 and 50 μg for the right coronary artery (RCA), and 20, 50 and 100 μg for the left coronary artery (LCA). However, provocation by low doses of ACh in patients with low vasoreactivity may be less needed, and the requirement of 50 μg of ACh for the LCA in these patients has not been evaluated. In the present study, patients who underwent ACh provocation test for both the RCA and LCA were included. The positive diagnosis of intracoronary ACh provocation test was defined as total or subtotal coronary artery narrowing (i.e., angiographic coronary artery spasm) accompanied by chest pain and/or ischemic electrocardiographic changes. Coronary artery constriction was visually evaluated and defined as coronary artery diameter reduction LCA. There were 33 out of 249 patients (13%) with LCA spasm by 20 µg of ACh. In subjects without LCA spasm by 20 µg of ACh, patients with coronary constriction LCA rarely showed coronary artery spasm induced by 50 μg of ACh in the LCA, in comparison to those with coronary constriction 25-90% (n = 115) (2.6 vs. 32.7%, p LCA had cardiac complications associated with administration of ACh. In conclusion, omission of 50 µg of ACh in the LCA may be possible when there is little coronary artery constriction by 20 µg of ACh in the LCA during provocation test, leading to less contrast and shortens overall procedure time.

  5. A Probabilistic Analysis of the Fermi Paradox

    OpenAIRE

    Solomonides, Evan; Terzian, Yervant

    2016-01-01

    The fermi paradox uses an appeal to the mediocrity principle to make it seem counter-intuitive that humanity has not been contacted by extraterrestrial intelligence. A numerical, statistical analysis was conducted to determine whether this apparent loneliness is, in fact, unexpected. An inequality was derived to relate the frequency of life arising and developing technology on a suitable planet in the galaxy, the average length of time since the first broadcast of such a civilization, and a c...

  6. Two Paradoxes in Linear Regression Analysis.

    Science.gov (United States)

    Feng, Ge; Peng, Jing; Tu, Dongke; Zheng, Julia Z; Feng, Changyong

    2016-12-25

    Regression is one of the favorite tools in applied statistics. However, misuse and misinterpretation of results from regression analysis are common in biomedical research. In this paper we use statistical theory and simulation studies to clarify some paradoxes around this popular statistical method. In particular, we show that a widely used model selection procedure employed in many publications in top medical journals is wrong. Formal procedures based on solid statistical theory should be used in model selection.

  7. Twin Paradox in de Sitter Spacetime

    CERN Document Server

    Boblest, Sebastian; Wunner, Günter

    2010-01-01

    The "twin paradox" of special relativity offers the possibility to make interstellar flights within a lifetime. For very long journeys with velocities close to the speed of light, however, we have to take into account the expansion of the universe. Inspired by the work of Rindler on hyperbolic motion in curved spacetime, we study the worldline of a uniformly accelerated observer in de Sitter spacetime and the communication between the traveling observer and an observer at rest.

  8. The twin paradox in relativity revisited

    OpenAIRE

    Natarajan, Vasant

    2012-01-01

    The accepted resolution of the twin paradox in relativity states that the age of the inertial twin `jumps' when the traveling twin undergoes his turn-around acceleration. This resolution is based on the use of the equivalent gravitational shift in the frame of the accelerating twin. We use the same analysis to propose a symmetric variant of the problem with the twins experiencing identical acceleration and deceleration phases, but which predicts conflicting results for the age of the other tw...

  9. Paradoxical escape responses by narwhals (Monodon monoceros)

    DEFF Research Database (Denmark)

    Williams, Terrie M.; Blackwell, Susanna B.; Richter, Beau

    2017-01-01

    Until recent declines in Arctic sea ice levels, narwhals (Monodon monoceros) have lived in relative isolation from human perturbation and sustained predation pressures. The resulting naïvety has made this cryptic, deep-diving cetacean highly susceptible to disturbance, although quantifiable effects...... have been lacking. We deployed a submersible, animal-borne electrocardiograph-accelerometer-depth recorder to monitor physiological and behavioral responses of East Greenland narwhals after release from net entanglement and stranding. Escaping narwhals displayed a paradoxical cardiovascular down...

  10. The molecular mechanisms of obesity paradox.

    Science.gov (United States)

    Antonopoulos, Alexios S; Tousoulis, Dimitris

    2017-07-01

    Clinical observations suggest a complex relationship between human obesity and cardiovascular disease. Whilst abdominal (visceral) adiposity leads to deleterious metabolic disturbances, subcutaneous fat accumulation has a benign effect on cardiometabolic risk. Notably, an accumulating body of evidence paradoxically links increased body mass index with a better prognosis in patients with established cardiovascular disease, a finding that has been termed the 'obesity paradox'. Whilst this is now acknowledged to be an epidemiological finding, a metabolically healthy obese group associated with low cardiovascular risk has also been identified. The current concept of adipose tissue (AT) biology suggests that AT expansion is feasible without accompanying adipocyte dysfunction. A metabolically healthy obese phenotype can be promoted by exercise, but is also linked with intrinsic AT molecular characteristics such as efficient fat storage and lipid droplet formation, high adipogenesis capacity, low extracellular matrix fibrosis, angiogenesis potential, adipocyte browning and low macrophages infiltration/activation. Such features are associated with a secretomic profile of human AT which is protective for the cardiovascular system. In the present review, we summarize the existing knowledge on the molecular mechanisms underlying the 'obesity paradox' and whether fatness can be healthy too. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2017. For permissions, please email: journals.permissions@oup.com.

  11. Obesity and poverty paradox in developed countries.

    Science.gov (United States)

    Żukiewicz-Sobczak, Wioletta; Wróblewska, Paula; Zwoliński, Jacek; Chmielewska-Badora, Jolanta; Adamczuk, Piotr; Krasowska, Ewelina; Zagórski, Jerzy; Oniszczuk, Anna; Piątek, Jacek; Silny, Wojciech

    2014-01-01

    Obesity is a civilization disease and the proportion of people suffering from it continues to grow, especially in the developed countries. Number of obese people in Europe has increased threefold over the last 20 years. The paradox of obesity and poverty relationship is observed especially in the developed and developing countries. In developing countries, along with economic development and income growth, the number of people with overweight and obesity is increasing. This paradox has a relationship with both the easy availability and low cost of highly processed foods containing 'empty calories' and no nutritional value. To date, this paradox has been described in the United States and the United Kingdom, although many European countries are also experiencing high percentages of obese people. Among the reasons for the growing obesity in the population of poor people are: higher unemployment, lower education level, and irregular meals. Another cause of obesity is low physical activity, which among the poor is associated with a lack of money for sports equipment. Due to the large rate of deaths caused by diseases directly linked to obesity, the governments of many countries implement prevention programmes of overweight and obesity. These programmes are based primarily on educating the public about a healthy lifestyle based on healthy eating, daily physical activity and avoiding alcohol and cigarettes.

  12. Fermi's paradox: The last challenge for copernicanism?

    Directory of Open Access Journals (Sweden)

    Ćirković M.M.

    2009-01-01

    Full Text Available We review Fermi's paradox (or the 'Great Silence' problem, not only arguably the oldest and crucial problem for the Search for ExtraTerrestrial Intelligence (SETI, but also a conundrum of profound scientific, philosophical and cultural importance. By a simple analysis of observation selection effects, the correct resolution of Fermi's paradox is certain to tell us something about the future of humanity. Already more than three quarters of century old puzzle and a quarter of century since the last major review paper in the field by G. David Brin has generated many ingenious discussions and hypotheses. We analyze the often tacit methodological assumptions built in various answers to this puzzle and attempt a new classification of the numerous solutions proposed in an already huge literature on the subject. Finally, we consider the ramifications of various classes of hypotheses for the practical SETI projects. Somewhat paradoxically, it seems that the class of (neocatastrophic hypotheses gives, on the balance, the strongest justification to optimism regarding our current and near-future SETI efforts.

  13. Laying the ghost of twin paradox

    Directory of Open Access Journals (Sweden)

    Popović Marko

    2009-01-01

    Full Text Available Someone's true age is not written in his ID, but in his biomarkers. Aging process is not caused by time passing, but by thermodynamically laws. Entropy, extent of metabolic reaction, and temperature are Lorentz invariant, so these facts make twin paradox impossible because there is no way for one twin to age slower than the other even if the time in his frame is dilated. Entropy is the function of state, not time. So as much as standard thermodynamics concerns, the path between two points in space is equivalent to the path between two states. Whether the point B is reached by moving faster using the longer way (with time dilatation, or slower by using shortcut (without time dilatation, the state of the system after completing the road should be the same. This is supported by the fact that when two twins reach the same space-time point (point B in which the state parameters are the same. If we use entropy as an age parameter, then both twins have the same entropy value and are exactly the same biological age. Therefore, the twin paradox is a logical mistake based on wrong first premise. Bergson symmetry is not necessary any more to explain the impossibility of twin paradox.

  14. Is there a paradox in obesity?

    Science.gov (United States)

    Goyal, Akankasha; Nimmakayala, Kameswara Rao; Zonszein, Joel

    2014-01-01

    In an industrialized society, the increase in obesity incidence has led to an increase in premature morbidity and mortality rates. There is a relationship between body mass index (BMI) and the increased incidence of hypertension, dyslipidemia, type 2 diabetes mellitus, and cardiovascular disease, an increase in mortality. However, obese individuals with these conditions may have better outcomes than their lean counterparts, thus the term "obesity paradox." Most studies supporting this paradox are cross-sectional and do not take into account the quantity or type of adiposity, the disease severity, and comorbidities. Although BMI is an indicator of the amount of body fat, it does not differentiate between adiposity types. Adipocytes that are highly functional have good fuel storage capacity are different from adipocytes found in visceral obesity, which are poorly functioning, laden with macrophages, and causing low-grade inflammation. Individuals with high BMI may be physically fit and have a lower mortality risk when compared with individuals with a lower BMI and poorly functioning adiposity. We review the complexity of adipose tissue and its location, function, metabolic implications, and role in cardiovascular morbidity and mortality. The terminology "obesity paradox" may reflect a lack of understanding of the complex pathophysiology of obesity and the association between adiposity and cardiovascular disease.

  15. The forgotten cause of stridor in the emergency department

    Directory of Open Access Journals (Sweden)

    Ng TT

    2017-01-01

    Full Text Available Tian-Tee Ng Ear, Nose and Throat Unit, Department of Surgery, Frankston Hospital, Peninsula Health, Frankston, VIC, Australia Abstract: Paradoxical Vocal Fold Movement Disorder is where the larynx exhibits paradoxical vocal cords closure during respiration, creating partial airway obstruction. Causes of vocal fold movement disorder are multifactorial, and patients describe tightness of throat, difficulty getting air in, have stridor, and do not respond to inhalers. We propose using transnasal laryngoscopy examination, which will show narrowing of vocal cords on inspiration, and The Pittsburgh Vocal Cord Dysfunction Index with a cutoff score of ≥4 to distinguish vocal fold movement disorder from asthma and other causes of stridor. Management of paradoxical vocal fold movement disorder involves a combination of pharmacological, psychological, psychiatric, and speech training. Paradoxical vocal fold movement disorder is a very treatable cause of stridor, so long as it is identified and other organic causes are excluded. Keywords: paradoxical vocal fold movement disorder, stridor, emergency

  16. Price Paradox and Strategic Choice of "Vegetable Basket" in China

    OpenAIRE

    Li, Wu

    2011-01-01

    By using the analysis method of game theory, this paper analyzes the phenomenon of price paradox of vegetable basket in China and its reason as follows: me price paradox of vegetable basket in China is that if the vegetable is cheap, it will harm farmers, and if the vegetable is expensive, it will harm people; high-cost logistics, low negotiation status of vegetable growers and cooperation predicament are responsible for price paradox. Based on the theoretical basis of strategic choice-theory...

  17. The Surprise Examination Paradox and the Second Incompleteness Theorem

    OpenAIRE

    Kritchman, Shira; Raz, Ran

    2010-01-01

    We give a new proof for Godel's second incompleteness theorem, based on Kolmogorov complexity, Chaitin's incompleteness theorem, and an argument that resembles the surprise examination paradox. We then go the other way around and suggest that the second incompleteness theorem gives a possible resolution of the surprise examination paradox. Roughly speaking, we argue that the flaw in the derivation of the paradox is that it contains a hidden assumption that one can prove the consistency of the...

  18. Paradoks kłamcy (Liar Paradox

    Directory of Open Access Journals (Sweden)

    Jan Wawrzyniak

    2011-09-01

    Full Text Available The aim of the article is to determine what role the liar sentence plays in our language. On the one hand, it seems to be well formed formula, and on the other, it does not seem to have any clear sense. At the beginning of the article I point what form an adequate solution of the liar paradox should take. In my opinion it could not consist in giving rules which do not allow to build such a sentence. The paradox remains unsolved until there is such a language in which it could be expressed.In the first part of the text I try to explain why Tarski’s solution is not satisfactory. If the semantical definition of truth is correct, the liar sentence could not lead to a contradiction because formulas which are not well formed could not be premisesof any inference. From that follows that the so called liar paradox does not arise and that leads to the conclusion: ‘the reconstruction’ of the liar propounded by Tarski could not be correct.In the second part I present an approach to the liar which appeals to Frege’s and Wittgenstein’s conceptions of language. The conclusion of my consideration is that the liar sentence is nonsense, which means it is not given any sense – either its logical form is determined but we do not fix any definite meaning to some parts of it, or an attempt to determine its logical form in the standard way leads to regressad infinitum.

  19. Paradoxical Manifestation is Common in HIV-negative Tuberculous Meningitis.

    Science.gov (United States)

    Tai, Mei-Ling Sharon; Nor, Hazman Mohd; Kadir, Khairul Azmi Abdul; Viswanathan, Shanthi; Rahmat, Kartini; Zain, Norzaini Rose Mohd; Ong, Kuo Ghee; Rafia, Mohd Hanip; Tan, Chong Tin

    2016-01-01

    Paradoxical manifestation is worsening of pre-existing tuberculous lesion or appearance of new lesions in patients whose condition initially improved with antituberculous treatment. Our hypothesis was that paradoxical manifestation in non-HIV tuberculous meningitis (TBM) patients was underestimated and this could contribute to patients' prognosis. This was the first systemic study of paradoxical manifestation in HIV-negative TBM patients. Between 2009 and 2014, TBM patients were studied prospectively in 2 hospitals. Clinical features, cerebrospinal fluid, and radiological findings were monitored. Paradoxical manifestation was divided into definite (4 weeks or more) and probable (between 14 and 27 d) after commencement of antituberculous treatment. Forty-one non-HIV TBM patients were recruited. Definite paradoxical manifestation occurred in 23/41 (56%) of the patients. Time to onset of paradoxical manifestation was between 28 days and 9 months, and majority was between 28 and 50 days. Neuroimaging manifestation in the brain (22/41 patients, 54%) and clinical manifestation (22/41 patients, 54%) were most commonly seen, followed by cerebrospinal fluid manifestation (7/41 patients, 17%). Neuroimaging changes most commonly seen were worsening of leptomeningeal enhancement, new infarcts, new tuberculomas, and enlargement of tuberculoma. Initial Computed Tomography Angiography/magnetic resonance angiography brain showed vasculitis in 14 patients, with 2 (12.5%) showing paradoxical vasculitis during follow-up. Recurrence of the paradoxical manifestation was seen in 7/23 (30%) of the patients. More than half (14/23, 61%) of the patients improved, 6 (26%) patients died, and 3 (13%) patients had persistent neurological deficit. Paradoxical manifestation was very common in non-HIV TBM patients. Neuroimaging paradoxical manifestation of 2-4 weeks may not be paradoxical manifestation but could be delayed treatment response.

  20. Conflicts in Africa and Major Powers: Proxy Wars, Zones of Influence or Provocative Instability

    Directory of Open Access Journals (Sweden)

    Jerry Rowlings Tafotie

    2016-12-01

    Full Text Available The article analyses the different nature of conflicts that have occurred in Africa since the end of Cold War. A special attention is given to the role of external factors in the process of conflict evolution and the escalation of violence on the African continent. In effect, this paper demonstrates through a critical examination of the meaning of proxy war as, zone of influence or provocation of instability as a strategy and an analysis of its employment by the United States and China, France etc. in Africa. The new potential confrontation between the United States and China as in Sudan, France in its former coloniesis not only based on a clash of world views about the structure and nature of international relations and security but largely over the control of strategically vital energy resources based in Africa. The authors conclude that this ultimately creates permanent tensions or bitter conflicts between the actors and African populations as a factor that have negative impact on the peace and stability of continent. According to the context of superpower conflict strategies, this paper critically examines, zone of influence, provoking of instability or proxy war as a viable national strategy of nuclear armed great powers in advancing and/or defending their global national interests in a bipolar/multipolar international system.

  1. Effects of gender and cigarette smoking on reactivity to psychological and pharmacological stress provocation.

    Science.gov (United States)

    Back, Sudie E; Waldrop, Angela E; Saladin, Michael E; Yeatts, Sharon D; Simpson, Annie; McRae, Aimee L; Upadhyaya, Himanshu P; Contini Sisson, Regana; Spratt, Eve G; Allen, Julia; Kreek, Mary Jeanne; Brady, Kathleen T

    2008-06-01

    We examined the influence of gender and smoking status on reactivity in two human laboratory stress paradigms. Participants were 46 (21 men, 25 women) healthy individuals who completed the Trier Social Stress Task (i.e., performed speech and math calculations in front of an audience) and a pharmacological stress provocation (i.e., administration of corticotrophin releasing hormone (CRH)) after an overnight hospital stay. Approximately half (53%) of the participants were smokers. Cortisol, adrenocorticotrophin hormone (ACTH), physiologic measures (heart rate, blood pressure), and subjective stress were assessed at baseline and at several time points post-task. Men demonstrated higher baseline ACTH and blood pressure as compared to women; however, ACTH and blood pressure responses were more pronounced in women. Women smokers evidenced a more blunted cortisol response as compared to non-smoking women, whereas smoking status did not affect the cortisol response in men. Finally, there was a more robust cardiovascular and subjective response to the Trier as compared to the CRH. Although preliminary, the findings suggest that women may be more sensitive than men to the impact of cigarette smoking on cortisol response. In addition, there is some evidence for a more robust neuroendocrine and physiologic response to acute laboratory stress in women as compared to men.

  2. Fear Processing in Dental Phobia during Crossmodal Symptom Provocation: An fMRI Study

    Directory of Open Access Journals (Sweden)

    Kevin Hilbert

    2014-01-01

    Full Text Available While previous studies successfully identified the core neural substrates of the animal subtype of specific phobia, only few and inconsistent research is available for dental phobia. These findings might partly relate to the fact that, typically, visual stimuli were employed. The current study aimed to investigate the influence of stimulus modality on neural fear processing in dental phobia. Thirteen dental phobics (DP and thirteen healthy controls (HC attended a block-design functional magnetic resonance imaging (fMRI symptom provocation paradigm encompassing both visual and auditory stimuli. Drill sounds and matched neutral sinus tones served as auditory stimuli and dentist scenes and matched neutral videos as visual stimuli. Group comparisons showed increased activation in the insula, anterior cingulate cortex, orbitofrontal cortex, and thalamus in DP compared to HC during auditory but not visual stimulation. On the contrary, no differential autonomic reactions were observed in DP. Present results are largely comparable to brain areas identified in animal phobia, but also point towards a potential downregulation of autonomic outflow by neural fear circuits in this disorder. Findings enlarge our knowledge about neural correlates of dental phobia and may help to understand the neural underpinnings of the clinical and physiological characteristics of the disorder.

  3. Exercice-induced bronchoconstriction among athletes: Assessment of bronchial provocation tests.

    Science.gov (United States)

    Vakali, S; Vogiatzis, I; Florou, A; Giavi, S; Zakynthinos, S; Papadopoulos, N G; Gratziou, Ch

    2017-01-01

    Diagnosis of exercise-induced bronchoconstriction (EIB) requires the use of bronchial provocation tests (BPTs). We assessed exercise-induced respiratory symptoms (EIRS), EIB and asthma in athletes and evaluated the validity of BPTs in the diagnosis of EIB. Rhinitis and atopy were also assessed. Athletes with (n=55) and without previous asthma diagnosis (n=145) were tested by skin prick tests, lung function and eNO measurements. EIRS were recorded and EIB was assessed by methacholine (Mch), eucapnic voluntary hyperpnoea (EVH), mannitol and exercise test. EIRS were highly reported and history of asthma was common among athletes. A high prevalence of atopy (48.7%) and allergic rhinitis (30.5%) was found. Athletes with asthma had a higher response rate to Mch and to EVH, as compared with athletes without a previous asthma diagnosis (P=0.012 and P=0.017 respectively). Report of EIRS, rhinitis and atopy were not associated with a positive BPT response. Screening athletes for EIB using BPTs is suggested, irrespective of reported EIRS or a previous asthma diagnosis. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. On recent advances in human engineering Provocative trends in embryology, genetics, and regenerative medicine.

    Science.gov (United States)

    Anton, Roman

    2016-01-01

    Advances in embryology, genetics, and regenerative medicine regularly attract attention from scientists, scholars, journalists, and policymakers, yet implications of these advances may be broader than commonly supposed. Laboratories culturing human embryos, editing human genes, and creating human-animal chimeras have been working along lines that are now becoming intertwined. Embryogenic methods are weaving traditional in vivo and in vitro distinctions into a new "in vivitro" (in life in glass) fabric. These and other methods known to be in use or thought to be in development promise soon to bring society to startling choices and discomfiting predicaments, all in a global effort to supply reliably rejuvenating stem cells, to grow immunologically non-provocative replacement organs, and to prevent, treat, cure, or even someday eradicate diseases having genetic or epigenetic mechanisms. With humanity's human-engineering era now begun, procedural prohibitions, funding restrictions, institutional controls, and transparency rules are proving ineffective, and business incentives are migrating into the most basic life-sciences inquiries, wherein lie huge biomedical potentials and bioethical risks. Rights, health, and heritage are coming into play with bioethical presumptions and formal protections urgently needing reassessment.

  5. Mechanisms of cough provocation and cough resolution in neonates with bronchopulmonary dysplasia.

    Science.gov (United States)

    Jadcherla, Sudarshan R; Hasenstab, Kathryn A; Shaker, Reza; Castile, Robert G

    2015-10-01

    Cough and deglutition are protective mechanisms that defend against aspiration. We identified mechanisms associated with cough provocation as well as those associated with cough resolution in infants with bronchopulmonary dysplasia (BPD). Manometry signatures of cough were recognized in 16 premature infants with BPD undergoing concurrent esophageal manometry, respiratory inductance plethysmography, and nasal air flow measurements. Pretussive and post-tussive pharyngo-esophageal motility changes were analyzed. Mechanisms associated with cough and mechanisms that restored respiratory and esophageal normalcy were analyzed. We analyzed 312 cough events during 88 cough clusters; 97% were associated with recognizable manometric patterns. Initial mechanisms related with coughing included nonpropagating swallow (59%), upper esophageal sphincter (UES) reflex contraction (18%), and lower esophageal sphincter (LES) relaxation (14%). UES and LES dysfunction was present in 69% of nonpropagating swallow-associated cough clusters. Mechanisms restoring post-tussive normalcy included primary peristalsis (84%), secondary peristalsis (8%), and none recognized (8%). UES contraction reflex was associated with cough clusters more frequently in infants on nasal continuous positive airway pressure (NCPAP) (OR = 9.13, 95% CI = 1.88-44.24). Cough clusters in infants with BPD had identifiable etiologies associated with esophageal events; common initial mechanisms were of upper aerodigestive origin, while common clearing mechanisms were peristaltic reflexes.

  6. Climate change communication: a provocative inquiry into motives, meanings, and means.

    Science.gov (United States)

    Johnson, Branden B

    2012-06-01

    The deliberately provocative theme of this article is that perceived difficulties in climate change communication (CCC)--e.g., indifference about or denial of climate change's reality, negative consequences, anthropogenic causes, or need to mitigate or adapt to it-are partly the fault of climate change communicators. Fischhoff's model of risk communication development is used to demonstrate that CCC to date has tended to stress persuasion, rather than social movement mobilization or deliberation, and with a focus on the model's early stages. Later stages are not necessarily better, but a more diverse strategy seems superior to a focus perhaps narrowed by empathic, ideological, psychological, and resource constraints. Furthermore, even within persuasion, emphasizing a wider set of values, consequences, and audiences could be fruitful. Social movement mobilization has its own set of weaknesses, but usefully complements persuasion with a focus on developing power, subverting mainstream assumptions, and engaging people in collective action. Deliberation similarly has its drawbacks, but unlike the other two approaches does not define the solution-or even, necessarily, the problem-in advance, and thus offers the chance for people of contending viewpoints to jointly develop concepts and action agendas hitherto unimagined. Simultaneous pursuit of all three strategies can to some degree offset their respective flaws, at the potential cost of diffusion of energies and contradictory messages. Success in CCC is by no means guaranteed by a more diverse set of strategies and self-reflection by communicators, but their pursuit should better reveal CCC's limits. © 2011 Society for Risk Analysis.

  7. Usefulness of drug provocation tests in children with a history of adverse drug reaction

    Directory of Open Access Journals (Sweden)

    Hye Ran Na

    2011-07-01

    Full Text Available Purpose : There are very few reports of adverse drug reactions (ADR and almost no study of drug provocation test (DPT in Korean children. We aimed to assess the role of DPT in children with unpredictable ADRs, and compare the causative drugs and clinical characteristics between detailed history of ADRs and result of DPTs. Methods : We included 16 children who were experienced ADRs referred to pediatric allergy clinic at Ajou University Hospital (January 2006 to December 2009. With various suspected drugs, 71 DPTs were done in 16 patients using our own protocol, and skin tests to antibiotics were combined in ADRs to antibiotics in medical history. Results : There were 17 (23.9% positive DPTs results out of 71 individual DPTs, and 11 patients (68.8% from 16 patients were positive to at least one drug. Drugs causing positive reactions were acetaminophen in 5 (31%, Non-steroidal anti-inflammatory drugs in 4 (25%, penicillin in 3 (19%, cephalosporin in 2 (13%, and cotrimoxazole, macrolide and lactose in 1 each. Conclusion : DPT seems a safe and useful procedure to confirm causative drug and identify safely administering alternative drugs in children with ADR.

  8. Paradox of integration-A computational model

    Science.gov (United States)

    Krawczyk, Małgorzata J.; Kułakowski, Krzysztof

    2017-02-01

    The paradoxical aspect of integration of a social group has been highlighted by Blau (1964). During the integration process, the group members simultaneously compete for social status and play the role of the audience. Here we show that when the competition prevails over the desire of approval, a sharp transition breaks all friendly relations. However, as was described by Blau, people with high status are inclined to bother more with acceptance of others; this is achieved by praising others and revealing her/his own weak points. In our model, this action smooths the transition and improves interpersonal relations.

  9. Obesity paradox, cachexia, frailty, and heart failure.

    Science.gov (United States)

    Lavie, Carl J; De Schutter, Alban; Alpert, Martin A; Mehra, Mandeep R; Milani, Richard V; Ventura, Hector O

    2014-04-01

    Overweight and obesity adversely affect cardiovascular (CV) risk factors and CV structure and function, and lead to a marked increase in the risk of developing heart failure (HF). Despite this, an obesity paradox exists, wherein those who are overweight and obese with HF have a better prognosis than their leaner counterparts, and the underweight, frail, and cachectic have a particularly poor prognosis. In light of this, the potential benefits of exercise training and efforts to improve cardiorespiratory fitness, as well as the potential for weight reduction, especially in severely obese patients with HF, are discussed. Copyright © 2014 Elsevier Inc. All rights reserved.

  10. The twin paradox in relativity revisited

    CERN Document Server

    Natarajan, Vasant

    2012-01-01

    The accepted resolution of the twin paradox in relativity states that the age of the inertial twin `jumps' when the traveling twin undergoes his turn-around acceleration. This resolution is based on the use of the equivalent gravitational shift in the frame of the accelerating twin. We use the same analysis to propose a symmetric variant of the problem with the twins experiencing identical acceleration and deceleration phases, but which predicts conflicting results for the age of the other twin. We also propose an unambiguous test of the standard resolution based on the Pound-Rebka experiment.

  11. On radar time and the twin ``paradox''

    Science.gov (United States)

    Dolby, Carl E.; Gull, Stephen F.

    2001-12-01

    In this paper we apply the concept of radar time (popularized by Bondi in his work on k calculus) to the well-known relativistic twin "paradox." Radar time is used to define hypersurfaces of simultaneity for a class of traveling twins, from the "immediate turn-around" case, through the "gradual turn-around" case, to the "uniformly accelerating" case. We show that this definition of simultaneity is independent of choice of coordinates, and assigns a unique time to any event (with which the traveling twin can send and receive signals), resolving some common misconceptions.

  12. The 'twin paradox' in relativistic rigid motion

    OpenAIRE

    Ben-Ya'acov, Uri

    2017-01-01

    Relativistic rigid motion suggests a new version for the so-called `twin paradox', comparing the ages of two astronauts on a very long spaceship. Although there is always an instantaneous inertial frame in which the whole spaceship, being rigid, is simultaneously at rest, the twins' ages, measured as the proper-times along their individual world lines, are different when they are located at remote parts of the spaceship. The age, or proper-time, difference depends on the distance at rest betw...

  13. Using Provocative Discography and Computed Tomography to Select Patients with Refractory Discogenic Low Back Pain for Lumbar Fusion Surgery

    OpenAIRE

    Xi, Mengqiao Alan; Tong, Henry C; Fahim, Daniel K; Perez-Cruet, Mick

    2016-01-01

    Background Context Controversy remains over the use of provocative discography in conjunction with computed tomography (CT) to locate symptomatic intervertebral discs in patients with chronic, low back pain (LBP).?The current study explores the relationship between discogenic pain and disc morphology using discography and CT, respectively, and investigates the efficacy of this combined method in identifying surgical candidates for lumbar fusion by evaluating outcomes. Methods 43 consecutive p...

  14. Comparison of levocabastine, a new selective H1-receptor antagonist, and disodium cromoglycate, in a nasal provocation test with allergen.

    OpenAIRE

    Kolly, M; Pécoud, A

    1986-01-01

    The effect of intranasal administration of levocabastine, a new selective H1-receptor antagonist, was investigated in a nasal provocation test (NPT) performed with allergens. The NPT allowed a quantitative estimation of the nasal allergic threshold (concentration of allergen necessary to trigger the reaction). In addition, the intensity of the three major rhinitis symptoms (obstruction, rhinorrhea and sneezing) was determined. Twelve adult patients, allergic to grass pollen, underwent a first...

  15. Moderating role of trait hope in the relation between painful and provocative events and acquired capability for suicide.

    Science.gov (United States)

    Mitchell, Sean M; Cukrowicz, Kelly C; Van Allen, Jason; Seegan, Paige L

    2015-01-01

    The interpersonal theory of suicide has gained empirical support as a conceptualization of suicide risk; however, little research has examined the role of individual traits, such as trait hope, within the interpersonal theory of suicide. The purpose of this study was to further investigate the role of trait hope components (i.e., pathways and agency) in acquired capability for suicide. Participants were 711 college students who completed measures of acquired capability for suicide, painful and provocative events, and trait hope (i.e., pathways and agency). Linear regression was used to test the hypotheses. As hypothesized, there was a positive relation between pathways and acquired capability. Contrary to our hypotheses, after controlling for gender there was a significant relation between agency and acquired capability. In addition, after controlling for gender, pathways did not moderate the relation between painful and provocative events and acquired capability, whereas agency did moderate this relation. Painful and provocative events should be assessed as a risk factor for acquired capability for suicide, and this may be more salient for individuals higher in the agency component of trait hope. Future research should consider examining the role of other traits within the interpersonal theory of suicide.

  16. Navigating the authority paradox: Practising objectivity in environmental expertise

    NARCIS (Netherlands)

    Kunseler, E.M.; Tuinstra, Willemijn

    We empirically reveal how environmental experts interpret the objectivity norm while navigating the authority paradox. The paradox here is that while there is a need for objective scientific advice, such advice is only to be acquired from experts and expert agencies whose objectivity and, hence,

  17. Simpson's paradox in psychological science: A practical guide

    NARCIS (Netherlands)

    Kievit, R.A.; Frankenhuis, W.E.; Waldorp, L.J.; Borsboom, D.

    2013-01-01

    The direction of an association at the population-level may be reversed within the subgroups comprising that population--a striking observation called Simpson's paradox. When facing this pattern, psychologists often view it as anomalous. Here, we argue that Simpson's paradox is more common than

  18. Obesity paradox in patients undergoing coronary intervention: A review

    OpenAIRE

    Patel, Nirav; Elsaid, Ossama; Shenoy, Abhishek; Sharma, Abhishek; McFarlane, Samy I.

    2017-01-01

    There is strong relationship exist between obesity and cardiovascular disease including coronary artery disease (CAD). However, better outcomes noted in obese patients undergoing percutaneous cardiovascular interventions for CAD, a phenomenon known as the obesity paradox. In this review, we performed extensive search for obesity paradox in obese patients undergoing percutaneous coronary intervention and discussed possible mechanism and disparities in different race and sex.

  19. Paradoxical cerebral air embolism; Embolismo gaseosos paradojico cerebral

    Energy Technology Data Exchange (ETDEWEB)

    Lopez-Negrete, L.; Garcia-Lozano, J.; Sanchez, J. L.; Sala, J. [Hospital Valle del Nalon. Riano.Langreo (Spain)

    2000-07-01

    We present a fatal case of intracranial air embolism produced by the passage of intravenous air to the arteries owing to the existence of a patent foremen ovale associated with pulmonary hypertension, which permitted a right-left shunt (paradoxical embolism). The pathophysiological mechanisms of pneumcephalus and paradoxical embolism are discussed and the pertinent literature is reviewed. (Author) 6 refs.

  20. Paradox and Double Binds in Adventure-Based Education.

    Science.gov (United States)

    Bacon, Stephen Barcia

    Paradox and therapeutic double bind techniques are used to overcome resistance in students with a history of success avoidance. Predictions of failure, restraining comments, and the use of paradox in the midst of an activity are defended theoretically by presenting historical roots and a rationale of effectiveness. A skill-building approach…

  1. Paradoxical Double Binds in Human-Relations Training.

    Science.gov (United States)

    Becvar, Raphael J.

    1978-01-01

    Paradoxical double binds are discussed relative to their efficacy in helping systematic human-relations trainees integrate the skills more quickly and with less pain and frustration. An explanation and examples of paradoxical double binds used in human-relations training are presented. (Author)

  2. An Applet for the Investigation of Simpson's Paradox

    Science.gov (United States)

    Schneiter, Kady; Symanzik, Jurgen

    2013-01-01

    This article describes an applet that facilitates investigation of Simpson's Paradox in the context of a number of real and hypothetical data sets. The applet builds on the Baker-Kramer graphical representation for Simpson's Paradox. The implementation and use of the applet are explained. This is followed by a description of how the applet has…

  3. Furthering Management and Spirituality Education through the Use of Paradox

    Science.gov (United States)

    Lips-Wiersma, Marjolein

    2004-01-01

    At present it is implicitly or explicitly recognized that various paradoxes surface in the application of spirituality in the management field. In this article, instead of acknowledging this and moving on to provide clarity, I articulate and stay with the paradoxes inherent in the area of study. Management education that engages with…

  4. The paradox of diabetes, obesity and cardiovascular risk

    African Journals Online (AJOL)

    2014-06-03

    Jun 3, 2014 ... may improve longevity irrespective of the degree of weight loss, or they may reflect that achieved weight loss is difficult to maintain, but nevertheless ... Is there an explanation for the obesity paradox? A number of theories have been proposed to explain the obesity paradox and differing results of clinical.

  5. The Lottery Paradox and the Pragmatics of Belief

    NARCIS (Netherlands)

    Douven, Igor

    The thesis that high probability suffices for rational belief, while initially plausible, is known to face the Lottery Paradox. The present paper proposes an amended version of that thesis which escapes the Lottery Paradox. The amendment is argued to be plausible on independent grounds.

  6. Two Different Worlds: A Paradox in Counseling and Psychotherapy

    Science.gov (United States)

    Gelso, Charles J.

    1970-01-01

    A basic paradox is proposed: both freedom and determinism are seen as valid models although they are basically contradictory. Whether or not freedom or determinism is valid depends upon the source of information the person is using at that time. Implications of the paradox for counseling practices are discussed. (Author)

  7. Transgression médiatique et provocations décadentes: La décadence comme comportement médiatique.

    OpenAIRE

    Yoan Vérilhac

    2012-01-01

    The decadent and symbolist movements are deeply connected to the creation of media: newspapers, small reviews which make the promotion of the young poets and their original works. In the 1880’s, the decadent reviews use in a provocative way the codes and the media potentialities. However this provocative press is based on a double language (especially about the relationship with the public), and this contradiction generates a negative image in the popular press: the new generation of poets an...

  8. [Characteristics of pulmonary function in children with atypical asthma with chest tightness as chief complaint before and after bronchial provocation test].

    Science.gov (United States)

    Wei, Wen; Lv, Min; Zhang, Jian; Hua, Shan; Shang, Qi-Yun

    2015-07-01

    To investigate the characteristics of pulmonary function in children with atypical asthma with chest tightness as the chief complaint before and after a bronchial provocation test. This study included 34 children with atypical asthmas who underwent bronchial provocation test between January 2010 and December 2013. Thirty-four children with typical asthmas were selected as the control group. The pulmonary function of the atypical asthma group was examined before and after the bronchial provocation test and compared with that of the control group in the acute episode and remission stages. The forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), FEV1/FVC, peak expiratory flow, forced expiratory flow 25%, 50%, 75% (FEF25, FEF50, FEF75), and maximum mid-expiratory flow (MMEF75/25) in the atypical asthma group before the bronchial provocation test were (105±12)%, (104±12)%, (100±7)%, (88±13)%, (90±14)%, (81±17)%, (73±25)%, and (80±17)%, respectively; these functional indices were significantly higher than in the control group in the acute episode stage (P0.05). In addition, no significant difference in pulmonary indices was observed between the atypical asthma group after the bronchial provocation test and the control group in the acute episode stage (P>0.05), but functional indices above were significantly lower in the atypical asthma group after the bronchial provocation test than in the control group in the remission stage and the atypical asthma group before the bronchial provocation test (PBronchial provocation test is useful in the diagnosis of atypical asthma in children.

  9. The Obesity Paradox and Cardiorespiratory Fitness

    Directory of Open Access Journals (Sweden)

    Paul A. McAuley

    2012-01-01

    Full Text Available Cardiorespiratory fitness as an explanation for the obesity paradox warrants further examination. We evaluated independent and joint associations of cardiorespiratory fitness and adiposity with all-cause mortality in 811 middle-aged (age, 53.3±7.2 years male never smokers without documented cardiopulmonary disease or diabetes from the Veterans Exercise Testing Study (VETS. Cardiorespiratory fitness was quantified in metabolic equivalents (METs using final treadmill speed and grade achieved on a maximal exercise test. Subjects were grouped for analysis by METs: unfit (lowest third and fit (upper two-thirds; and by body mass index (kg/m2: nonobese (18.5−29.9 and obese (≥30.0. Associations of baseline fitness and adiposity measures with all-cause mortality were determined by Cox proportional hazards analysis adjusted for age, ethnicity, hypertension, hypercholesterolemia, family history of coronary artery disease, and cardiovascular medication use. In multivariate analysis, mortality risk for obese/fit men did not differ significantly from the nonobese/fit reference group. However, compared to the reference group, nonobese and obese unfit men were 2.2 (=0.01 and 1.9 (=0.03 times more likely to die, respectively. Cardiorespiratory fitness altered the obesity paradox such that mortality risk was lower for both obese and nonobese men who were fit.

  10. Parenting paradox: parenting after infant loss.

    Science.gov (United States)

    Warland, Jane; O'Leary, Joann; McCutcheon, Helen; Williamson, Victoria

    2011-10-01

    to gain an in-depth understanding of the parenting experiences of bereaved parents in the years following an infant death. an exploratory qualitative study. semi-structured interview in the participants' homes. Data were collected over a five-month period in 2008 and analysed using thematic analysis. a purposive sample of 13 bereaved parents (10 mothers and three fathers) was used. Parents who had accessed the support services offered by two bereavement support agencies were recruited. Participants were asked to describe their experiences of raising their subsequent child. Interviews were conducted when the next born child was at least three years of age. the parents described a 'paradoxical' parenting style where they were trying to parent using two diametrically opposed unsustainable options. For example, they described trying to hold their subsequent child emotionally close but aloof at the same time. the results from this study indicate that the impact of a loss of an infant has far-reaching consequences on subsequent parenting. Support and early intervention at the time of the stillbirth and subsequent pregnancy are likely to be useful. However, further research is required to determine the extent to which early intervention can alter the tendency towards bereaved parents adopting a paradoxical parenting style. The impact of this style on mental health and the emotional health and well-being of the next born child/ren after perinatal loss should also be further examined. Copyright © 2010 Elsevier Ltd. All rights reserved.

  11. Fermi's Paradox - The Last Challenge For Copernicanism?

    Directory of Open Access Journals (Sweden)

    Ćirković, M. M.

    2009-06-01

    Full Text Available We review Fermi's paradox (or the "Great Silence" problem, not only arguably the oldest and crucial problem for the Search for ExtraTerrestrial Intelligence (SETI, but also a conundrum of profound scientific, philosophical and cultural importance. By a simple analysis of observation selection effects, the correct resolution of Fermi's paradox is certain to tell us something about the future of humanity. Already more than three quarters of century old puzzle -- and a quarter of century since the last major review paper in the field by G. David Brin -- has generated many ingenious discussions and hypotheses. We analyze the often tacit methodological assumptions built in various answers to this puzzle and attempt a new classification of the numerous solutions proposed in an already huge literatureon the subject. Finally, we consider the ramifications of variousclasses of hypotheses for the practical SETI projects. Somewhatparadoxically, it seems that the class of (neocatastrophichypotheses gives, on the balance, the strongest justification tooptimism regarding our current and near-future SETI efforts.

  12. An experimental study of the Online Information Paradox: Does en-route information improve road network performance?

    Directory of Open Access Journals (Sweden)

    Kasun P Wijayaratna

    Full Text Available This study investigates the empirical presence of a theoretical transportation paradox, defined as the "Online Information Paradox" (OIP. The paradox suggests that, for certain road networks, the provision of online information deteriorate travel conditions for all users of that network relative to the situation where no online information is provided to users. The analytical presence of the paradox was derived for a specific network structure by using two equilibrium models, the first being the Expected User Equilibrium (EUE solution (no information scenario and the other being the User Equilibrium with Recourse (UER solution (with information scenario. An incentivised computerised route choice game was designed using the concepts of experimental economics and administered in a controlled laboratory environment to investigate the physical presence of the paradox. Aggregate statistics of path flows and Total System Travel Costs (TSTC were used to compare the experimental results with the theoretical findings. A total of 12 groups of 12 participants completed the experiment and the OIP and the occurrence of the OIP being significant was observed in 11 of the 12 cases. Though information increased travel costs for users on average, it reduced the volatility of travel costs experienced in the no information scenario indicating that information can achieve a more reliable system. Further replications of similar experiments and more importantly field based identification of the phenomena will force transport professionals to be aware of the emergence of the paradox. In addition, studies such as this emphasise the need for the adoption of adaptive traffic assignment techniques to appropriately model the acquisition of information on a road network.

  13. Unveiling consumer's privacy paradox behaviour in an economic exchange.

    Science.gov (United States)

    Motiwalla, Luvai F; Li, Xiao-Bai

    2016-01-01

    Privacy paradox is of great interest to IS researchers and firms gathering personal information. It has been studied from social, behavioural, and economic perspectives independently. However, prior research has not examined the degrees of influence these perspectives contribute to the privacy paradox problem. We combine both economic and behavioural perspectives in our study of the privacy paradox with a price valuation of personal information through an economic experiment combined with a behavioural study on privacy paradox. Our goal is to reveal more insights on the privacy paradox through economic valuation on personal information. Results indicate that general privacy concerns or individual disclosure concerns do not have a significant influence on the price valuation of personal information. Instead, prior disclosure behaviour in specific scenario, like with healthcare providers or social networks, is a better indicator of consumer price valuations.

  14. Obesity Paradox in the Course of Cerebrovascular Diseases.

    Science.gov (United States)

    Brzecka, Anna; Ejma, Maria

    2015-01-01

    Obesity remains an important risk factor of cardiovascular and cerebrovascular diseases. However, it has been observed that increased body fat and body mass index predicted longer survival after the occurrence of a cardiovascular event. This observation has been named the obesity paradox. Initially, the term obesity paradox referred to the observation of the better outcome of cardiovascular diseases, such as heart failure and coronary heart disease, in obese patients as compared to underweight and normal-weight patients. Recently, similar, although fewer, observations confirm the occurrence of the obesity paradox in patients with acute cerebrovascular diseases. The underlying reasons for the protective effects of excessive body fat tissue against the consequences of acute cardiovascular and cerebrovascular diseases are poorly understood. The effect of preconditioning may be associated with the obesity paradox. The issue of the correlation between obesity and better survival of patients with cardiovascular and cerebrovascular diseases still remains largely unexplored. Debates for and against the obesity paradox continue.

  15. Internal disc derangement in patients with low back pain: correlation of MR imaging and provocative discography and CT discography

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Hye Won [Samsung Medical Center, Seoul (Korea, Republic of); Cheon, Jung Eun; Hong, Sung Hwan; Kang, Heung Sik; Lee, Ji Ho; Oh, Joo Han [College of Medicine, Seoul National Univ., Seoul (Korea, Republic of); Jeon, Pyoung [National Health Insurance Corporation Ilsan Hospital, Goyang (Korea, Republic of)

    2004-11-01

    The aim of this study was to correlate the MR imaging abnormalities of the lumbar intervertebral discs, with emphasis being placed on the high intensity zone (HIZ) with the use of discography for pain provocation and disc morphologic evaluation of the disc. Consecutive patients with low back pain unresponsive to conservative treatment, and who were being considered for spinal fusion had MRI performed, and this was followed by lumbar discography. The MR imaging, discography and CT discography (CTD) were evaluated for all of the 19 patients. Forty-three lumbar discs in 19 patients were included in this study. The findings of MR and CTD images were evaluated retrospectively with the professional opinion and agreement of two radiologists. MR images were assessed for the presence or absence of decreased T2-wighted signal intensity, decreased disc height, annular bulging, HIZ on T2-weighted images and disc herniation. The results of pain provocation were graded as 0, nonconcordant pain; 1, definite pain, but only as part of the symptom complex; 2, concordant pain. The morphology of CTD was analyzed for presence or absence of disc degeneration, radial tearing and extravasation of the contrast agent. The presence of radial tearing was defined as contrast extension to the outer third of the annulus. The prevalence of all MR abnormalities was calculated, and the data were compared with disc morphologic characteristics and the pain response on provocative discography. We used the chi-square test to analyze the results. Grade 1 and 2 discogenic pain was observed in 8 (19%) and 12 disc levels (28%), respectively. All of the seven non-degenerated discs on MR had no pain response. The decreased SI on T2-weighted image, annular bulging and HIZ were significantly correlated with discogenic pain. Extravasation of contrast media had good correlation with annular bulging and disc herniation on MRI. Radial tearing on CT discography correlated significantly with HIZ. The HIZ was

  16. From the BMI paradox to the obesity paradox: the obesity-mortality association in coronary heart disease.

    Science.gov (United States)

    Antonopoulos, A S; Oikonomou, E K; Antoniades, C; Tousoulis, D

    2016-10-01

    Despite a strong association between body weight and mortality in the general population, clinical evidence suggests better clinical outcome of overweight or obese individuals with established coronary heart disease. This finding has been termed the 'obesity paradox', but its existence remains a point of debate, because it is mostly observed when body mass index (BMI) is used to define obesity. Inherent limitations of BMI as an index of adiposity, as well as methodological biases and the presence of confounding factors, may account for the observed findings of clinical studies. In this review, our aim is to present the data that support the presence of a BMI paradox in coronary heart disease and then explore whether next to a BMI paradox a true obesity paradox exists as well. We conclude by attempting to link the obesity paradox notion to available translational research data supporting a 'healthy', protective adipose tissue phenotype. © 2016 World Obesity. © 2016 World Obesity.

  17. Opioid Hypersensitivity: Predictors of Allergy and Role of Drug Provocation Testing.

    Science.gov (United States)

    Li, Philip H; Ue, Kok Loong; Wagner, Annette; Rutkowski, Ryszard; Rutkowski, Krzysztof

    True IgE-mediated hypersensitivity to opioids is rare and many reactions are due to direct mast cell degranulation. Opioid drug provocation testing (DPT) is the gold standard for diagnosis but is underutilized. The objective of this study was to evaluate the clinical characteristics and predictors of opioid hypersensitivity, as well as outcomes of opioid DPT. Patients referred for opioid DPT over the past 9 years were studied. Patient characteristics, indications for opioid use, symptoms of index reaction, and outcomes of DPT were analyzed. Association analysis was performed to study variables associated with a diagnosis of opioid hypersensitivity. Of the total of 98 patients referred with suspected opioid hypersensitivity, 15 (15%) were diagnosed with opioid allergy. Angioedema (odds ratio [OR]: 5.66; 95% confidence interval [CI]: 1.49-21.47; P = .011) and hypotension (OR: 5.00; 95% CI: 1.15-21.70; P = .032) were significantly more frequent in opioid allergic patients than those with a negative DPT. Patients who received opioids during anesthesia were significantly more likely to be opioid allergic (OR: 6.74; 95% CI: 2.05-22.13; P = .001). In contrast, a negative association was identified with patients who received opioids for analgesia (OR: 0.27; 95% CI: 0.08-0.86; P = .008). Only 15% of our cohort were diagnosed with opioid allergy, emphasizing the importance of DPT in preventing erroneous overdiagnosis. Patients with a history of angioedema or hypotension as their index reaction were significantly more likely to be opioid allergic. DPT are safe when performed by experienced clinicians after risk stratification and using individualized protocols. Copyright © 2017 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

  18. Amoxicillin allergy in children: five-day drug provocation test in the diagnosis of nonimmediate reactions.

    Science.gov (United States)

    Mori, Francesca; Cianferoni, Antonella; Barni, Simona; Pucci, Neri; Rossi, Maria Elisabetta; Novembre, Elio

    2015-01-01

    The drug provocation test (DPT) is the gold standard to rule out drug hypersensitivity. There are standardized DPT protocols to diagnose immediate reactions to drugs, but not for nonimmediate reactions. The aim of this study was to show the sensitivity and specificity of an allergy work-up that included a 5-day DPT in children with histories of nonimmediate reactions to amoxicillin through focusing on a pediatric population with histories of immediate and nonimmediate reactions to amoxicillin. Two hundred consecutive patients with histories of amoxicillin reactions referred to the Allergy Unit of Anna Meyer Children's Hospital for suspected drug allergy from 2008 to 2011 underwent in vivo tests with the culprit drug according to European Academy of Allergy and Clinical Immunology guidelines. Moreover, most of those children, regardless of the skin tests results, were challenged with amoxicillin for a total of 5 days. In 4 years, 200 patients were evaluated for a history of drug hypersensitivity to amoxicillin. The majority of patients (76%) had a history of mild nonimmediate reactions. All 200 patients underwent skin tests, and 9 of 200 tested positive. A total of 177 DPTs were performed with amoxicillin for 5 days in each child. Diagnosis of amoxicillin allergy was confirmed by a DPT in 17 patients (9.6%); 14/17 had history of nonimmediate reactions; 4/14 (26.6%) reacted on day 5. According to our results, a long-term DPT protocol increases the sensitivity of the allergy work-up, and it should be recommended for patients with a history of amoxicillin nonimmediate reaction. Copyright © 2015 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

  19. Clinical value of single versus composite provocative clinical tests in the assessment of painful shoulder.

    Science.gov (United States)

    Salaffi, Fausto; Ciapetti, Alessandro; Carotti, Marina; Gasparini, Stefania; Filippucci, Emilio; Grassi, Walter

    2010-04-01

    The aims of the present study were to investigate the clinical value of the provocative clinical tests and propose a composite index for the assessment of painful shoulder, using ultrasonography (US) as reference method. Two hundred three patients with painful shoulder underwent both clinical and US evaluations. The physical examination was carried out performing the Hawkins, Jobe, Patte, Gerber, and Speed tests. Each test was included in a composite index namely, SNAPSHOT (Simple Numeric Assessment of Pain by SHOulder Tests). The US examination was performed by a rheumatologist experienced in US and blinded to clinical findings. Sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratio of each clinical test were calculated. The receiver operating characteristic (ROC) curve analysis was used to assess the performance of the composite SNAPSHOT index. Sensitivity was low for the clinical diagnosis of all shoulder abnormalities. The highest sensitivity and smallest negative likelihood ratio were found for the Hawkins (63.88% and 0.50%) and Patte (62.21% and 0.52%) tests. Specificity was good for Speed (76.33%), Gerber (75.42%), and Patte (74.20%) tests. Patte and Speed tests were the most accurate (71.12% and 66.41%, respectively). The calculated area under the ROC curve related to the SNAPSHOT composite index was 0.881 +/- 0.026. With an optimal cut-off point of 3, the sensitivity and specificity were 75.8% and 87.5%, respectively. The results of the present study showed that SNAPSHOT is a feasible, informative and quantitative composite index for the assessment of painful shoulder in the clinical setting.

  20. Evaluation of drug provocation test-related anxiety in patients with drug hypersensitivity.

    Science.gov (United States)

    Soyyiğit, Şadan; Aydın, Ömür; Yılmaz, İnsu; Özdemir, Seçil Kepil; Cankorur, Vesile Şentürk; Atbaşoğlu, Cem; Çelik, Gülfem Elif

    2016-09-01

    Drug provocation tests (DPTs) are important in the treatment of patients with drug hypersensitivity (DH), but they carry certain hypersensitivity reaction risks, which lead to procedure-related concerns in patients. To investigate DPT-related anxiety and its effect on long-term use of tested drugs. The study included patients who underwent DPT from July 1, 2009, to July 1, 2012. After recording the patients' history and characteristics, a variety of psychiatric (Hospital Anxiety and Depression Scale, Panic and Agoraphobia Scale, and the Maudsley Obsessive-Compulsive Inventory) and quality-of-life (36-item Short Form Health Survey) tests were performed. DPT-related anxiety was also evaluated using a visual analog scale. The patients were requestioned about whether they had used the tested drug within 1 year. A total of 126 patients were included in the study. According to the Hospital Anxiety and Depression Scale, 23.4% and 30.6% of the patients had depression and anxiety symptoms, respectively. The mean (SD) visual analog scale anxiety scores after a negative DPT result were lower than those before DPTs (2 [2.5] after vs 5.2 [3.4] before; P anxiety related to drug reactions, despite negative DPT results and symptoms indicated for use of the drug. Our findings suggest that DPTs in themselves cause significant anxiety in patients with DH. Importantly, anxiety levels decreased after a negative test result. However, our results also suggested that a negative DPT result is not convincing enough for some patients to use the tested drug when needed in the future. Therefore, supporting strategies appear to be the most effective way to eliminate DH-related anxiety of patients. Copyright © 2016 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

  1. Provocation proven drug allergy in Thai children with adverse drug reactions.

    Science.gov (United States)

    Indradat, Somying; Veskitkul, Jittima; Pacharn, Punchama; Jirapongsananuruk, Orathai; Visitsunthorn, Nualanong

    2016-03-01

    Adverse drug reactions (ADRs) are a common healthcare problem. The drug provocation test (DPT) is a gold standard for ADR diagnosis. To evaluate a correlation between history of ADRs, skin prick test (SPT), intradermal test (ID) and DPT in Thai children. This was a retrospective review of 211 children under 16 years of age who had a history of ADRs and underwent DPT from January 2006 to December 2012. Two hundred and thirty six (236) DPTs were performed in 211 children with a history of ADRs. The median age at which DPTs were performed was 4 years. Thirty-four children (14.4%) had positive DPT. The positive predictive value (PPV), negative predictive value (NPV), sensitivity, specificity, likelihood ratio (LR) + and LR- of SPT were 50, 85.7, 6.9, 98.8%, 5.8 and 0.9, respectively. The PPV, NPV, sensitivity, specificity, LR+ and LR- of ID were 33.3, 84.6, 20, 91.7%, 2.4 and 0.9, respectively. Different presentation of symptoms (maculopapular rashes, urticaria, angioedema and anaphylaxis) did not predict SPT, ID and DPT results. Positive human immunodeficiency virus (HIV), but not atopy, was a risk in the present scope of evaluation for drug allergy (odds ratio 11.44, 95% confidence interval 2.60-50.41). Drug allergy, denoted by positive DPT, was present in 14.4% of Thai children with a history of ADRs. Antibiotics were the most common cause of ADRs. Both SPT and ID had high NPV and specificity but did not predict DPT results. HIV positivity is a risk factor of drug allergy in Thai children.

  2. Esophageal reflexes modulate frontoparietal response in neonates: Novel application of concurrent NIRS and provocative esophageal manometry

    Science.gov (United States)

    Pakiraih, Joanna F.; Hasenstab, Kathryn A.; Dar, Irfaan; Gao, Xiaoyu; Bates, D. Gregory; Kashou, Nasser H.

    2014-01-01

    Central and peripheral neural regulation of swallowing and aerodigestive reflexes is unclear in human neonates. Functional near infrared spectroscopy (NIRS) is a noninvasive method to measure changes in oxyhemoglobin (HbO) and deoxyhemoglobin (HbD). Pharyngoesophageal manometry permits evaluation of aerodigestive reflexes. Modalities were combined to investigate feasibility and to test neonatal frontoparietal cortical changes during pharyngoesophageal (visceral) stimulation and/or swallowing. Ten neonates (45.6 ± 3.0 wk postmenstrual age, 4.1 ± 0.5 kg) underwent novel pharyngoesophageal manometry concurrent with NIRS. To examine esophagus-brain interactions, we analyzed cortical hemodynamic response (HDR) latency and durations during aerodigestive provocation and esophageal reflexes. Data are presented as means ± SE or percent. HDR rates were 8.84 times more likely with basal spontaneous deglutition compared with sham stimuli (P = 0.004). Of 182 visceral stimuli, 95% were analyzable for esophageal responses, 38% for HDR, and 36% for both. Of analyzable HDR (n = 70): 1) HbO concentration (μmol/l) baseline 1.5 ± 0.7 vs. 3.7 ± 0.7 poststimulus was significant (P = 0.02), 2) HbD concentration (μmol/l) between baseline 0.1 ± 0.4 vs. poststimulus −0.5 ± 0.4 was not significant (P = 0.73), and 3) hemispheric lateralization was 21% left only, 29% right only, and 50% bilateral. During concurrent esophageal and NIRS responses (n = 66): 1) peristaltic reflexes were present in 74% and HDR in 61% and 2) HDR was 4.75 times more likely with deglutition reflex vs. secondary peristaltic reflex (P = 0.016). Concurrent NIRS with visceral stimulation is feasible in neonates, and frontoparietal cortical activation is recognized. Deglutition contrasting with secondary peristalsis is related to cortical activation, thus implicating higher hierarchical aerodigestive protective functional neural networks. PMID:24789204

  3. Alpha-9 nicotinic acetylcholine receptors mediate hypothermic responses elicited by provocative motion in mice.

    Science.gov (United States)

    Tu, Longlong; Poppi, Lauren; Rudd, John; Cresswell, Ethan T; Smith, Doug W; Brichta, Alan; Nalivaiko, Eugene

    2017-05-15

    Hypothermic responses accompany motion sickness in humans and can be elicited by provocative motion in rats. We aimed to determine the potential role in these responses of the efferent cholinergic vestibular innervation. To this end, we used knockout (KO) mice lacking α9 cholinoreceptor subunit predominantly expressed in the vestibular hair cells and CBA strain as a wild-type (WT) control. In WT mice, circular horizontal motion (1Hz, 4cm radius, 20min) caused rapid and dramatic falls in core body temperature and surface head temperature associated with a transient rise in the tail temperature; these responses were substantially attenuated in KO mice; changes were (WT vs. KO): for the core body temperature-5.2±0.3 vs. -2.9±0.3°C; for the head skin temperature-3.3±0.2 vs. -1.7±0.2°C; for the tail skin temperature+3.9±1.1 vs+1.1±1.2°C. There was a close correlation in the time course of cooling the body and the surface of the head. KO mice also required 25% more time to complete a balance test. We conclude: i) that the integrity of cholinergic efferent vestibular system is essential for the full expression of motion-induced hypothermia in mice, and that the role of this system is likely facilitatory; ii) that the system is involvement in control of balance, but the involvement is not major; iii) that in mice, motion-induced body cooling is mediated via increased heat flow through vasodilated tail vasculature and (likely) via reduced thermogenesis. Our results support the idea that hypothermia is a biological correlate of a nausea-like state in animals. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Provocation of coronary vasospastic angina using an isoproterenol head-up tilt test.

    Science.gov (United States)

    Hung, Ming-Jui; Wang, Chao-Hung; Cherng, Wen-Jin

    2004-01-01

    The goals of this study were to determine the value of the isoproterenol (ISO) head-up tilt (HUT) test in detecting coronary vasospastic angina and to investigate the possible mechanism responsible for coronary artery spasm. The ISO + HUT test was performed in 16 patients with coronary artery spasm documented by the intracoronary ergonovine provocation test. Patients' blood pressure and heart rate were measured at baseline, during the ISO + HUT (phase I), and during HUT after discontinuation of ISO (phase II). Patients were categorized as test-positive if they developed angina with ST-segment elevation during testing. Eight patients (50%) were test-positive (5 in phase I and 3 in phase II). Between the test-positive and test-negative groups, no significant differences were noted in the changes in blood pressure throughout the test. However, there were significant differences in the changes in heart rate from supine to 2 minutes after HUT under ISO infusion (-17 +/-22 vs 11 +/-25 beats/minute; p=0.035). In those patients with a positive result in the phase I stage, the heart rate decreased initially after tilt-up, and then significantly increased later (from 85 +/-16 to 110 +/-27 beats/minute; p=0.043), when coronary vasospasm occurred. In those patients with a positive result in the phase II stage, coronary vasospasm occurred immediately after HUT, when there was an insignificant transient increase in heart rate from the supine to the HUT position (from 85 +/-12 to 92 +/-11 beats/minute; p=0.109). The ISO + HUT test can provoke coronary vasospasm with ST-segment elevation in 50% of the patients with coronary artery spasm, when combined with an extensional protocol of HUT after discontinuation of ISO. This study suggests that the induction of coronary artery spasm during HUT testing is associated with a rapid elevation of sympathetic activity during augmented parasympathetic activity.

  5. A paradox in individual-based models of populations.

    Science.gov (United States)

    van der Meer, Jaap

    2016-01-01

    The standard dynamic energy budget model is widely used to describe the physiology of individual animals. It assumes that assimilation rate scales with body surface area, whereas maintenance rate scales with body volume. When the model is used as the building block of a population model, only limited dynamical behaviour, the so-called juvenile-driven cycles, emerges. The reason is that in the model juveniles are competitively superior over adults, because juveniles have a higher surface area-to-volume ratio. Maintenance requirements for adults are therefore relatively large, and a reduced assimilation rate as a result of lowered food levels will easily become insufficient. Here, an alternative dynamic energy budget model is introduced that gives rise to adult-driven cycles, which may be closer to what is often observed in reality. However, this comes at the price of a rather odd description of the individual, in that maintenance scales with body area and assimilation rate with body volume, resulting in unbounded exponential body growth. I make a plea to solve the paradox and come up with reliable descriptions at both the individual and the population level.

  6. Patrick Pearse: Psychobiographical Reflections on an Enigmatic, Paradoxical Personality

    Directory of Open Access Journals (Sweden)

    Orr, Patricia Meredith

    2016-06-01

    Full Text Available To date historians have focused almost exclusively on Patrick Pearse’s key role in the 1916 Easter Rising to the extent that there is much less information about his personality development and characteristics. They have portrayed the elusive, paradoxical Patrick as nationalist, revolutionary and martyr or as a flawed and failed human being. Moran, agreeing with comments made at an earlier time by F.S.L. Lyons, suggests that, to have any real understanding of Patrick’s role in the rebellion and the events that led up to it, historians need to focus more attention on understanding the man himself.[1] The approach used in this article is psychobiographical, a methodology that applies psychological theory to biographical information in order to more fully understand an individual’s personality and achievements. In the case of Patrick Pearse the biographical information focuses on consensual aspects of his family background, his life experiences, his role as educator and his emergence as leader and hero. With regard to psychological theory, there are many empirically supported perspectives than could have been applied in this psychobiography. However, for the purposes of this particular article three perspectives have been selected. Drawing on some main tenets of the psychoanalytic, humanistic and trait approaches, the authors hope to provide a broader understanding of the influences and experiences that may have shaped Pearse as son, sibling, peer, educator and ultimately as a main instigator of the 1916 Rising and one of Ireland’s most famous patriots.

  7. Simpson’s Paradox in Psychological Science: A Practical Guide

    Directory of Open Access Journals (Sweden)

    Rogier eKievit

    2013-08-01

    Full Text Available The direction of an association at the population-level may be reversed within the subgroups comprising that population—a striking observation called Simpson’s paradox. When facing this pattern, psychologists often view it as anomalous. Here, we argue that Simpson’s paradox is more common than conventionally thought, and typically results in incorrect interpretations – potentially with harmful consequences. We support this claim by drawing on empirical results from cognitive neuroscience, behavior genetics, psychopathology, personality psychology, educational psychology, intelligence research, and simulation studies. We show that Simpson’s Paradox is most likely to occur when inferences are drawn across different levels of explanation (e.g., from populations to subgroups, or subgroups to individuals. We propose a set of statistical markers indicative of the paradox, and offer psychometric solutions for dealing with the paradox when encountered—including a toolbox in R for detecting Simpson’s Paradox. We show that explicit modeling of situations in which the paradox might occur not only prevents incorrect interpretations of data, but also results in a deeper understanding of what data tell us about the world.

  8. Paradoxical motion in L5-S1 adult spondylolytic spondylolisthesis.

    Science.gov (United States)

    Oh, Jacob Yoong-Leong; Liang, Shen; Louange, Danny; Rahmat, Razmi; Hee, Hwan-Tak; Kumar, V P

    2012-02-01

    In patients with spondylolisthesis, it is assumed that flexion accentuates anterior displacement, whereas extension causes some reduction. Paradoxical movement-where flexion causes reduction of spondylolisthesis and extension increases the anterior translation, is rarely described. In this study, we investigate the prevalence of paradoxical motion in patients with L5-S1 spondylolytic spondylolisthesis and why this abnormal motion occurs. Flexion and extension radiographs of 41 patients with grade I and II spondylolytic spondylolisthesis of the L5-S1 segment were analysed. Patients who had previous lumbar spine surgery, recent lumbar spine trauma, those more than 50 years of age and those with poor quality radiographs were excluded. There were 24 male and 17 female patients. The average age was 32.7 years. Of the 41 patients, 29 (70.7%) showed no significant instability. Six (15%) patients showed anterolisthesis, where flexion accentuated the forward displacement, while further six (15%) patients showed paradoxical motion. Statistical analyses found that patients with paradoxical motion had a significantly higher slip angle. In this study, we have demonstrated that: (1) paradoxical motion in spondylolytic spondylolisthesis is more common than previously thought. (2) Patients without anterolisthesis during flexion in dynamic radiographs may still have (paradoxical) instability. (3) Paradoxical motion may be more common in patients with a low sacral slope and increased lumbosacral lordosis.

  9. Anorexia nervosa--irony, misnomer and paradox.

    Science.gov (United States)

    Lask, Bryan; Frampton, Ian

    2009-05-01

    Anorexia nervosa is a condition full of irony and paradox. Perhaps the most enigmatic of these is that professionals tend to hold the same morbid preoccupation with weight, BMI and targets as do our patients. In this article we outline why we believe that an over-emphasis on weight/BMI and targets is inappropriate, misleading and potentially harmful. Although this view is not always greeted with enormous enthusiasm by some, others are relieved that this particular 'holy cow' is at last being challenged. It is important that we should all have an open mind to the possibility that one of the main tenets of our practice may actually be unhelpful. Some ancient wisdom is drawn upon to support this view.

  10. Cannabinoid Hyperemesis Syndrome: A Paradoxical Cannabis Effect

    Directory of Open Access Journals (Sweden)

    Ivonne Marie Figueroa-Rivera

    2015-01-01

    Full Text Available Despite well-established antiemetic properties of marijuana, there has been increasing evidence of a paradoxical effect in the gastrointestinal tract and central nervous system, given rise to a new and underrecognized clinical entity called the Cannabinoid Hyperemesis Syndrome. Reported cases in the medical literature have established a series of patients exhibiting a classical triad of symptoms: cyclic vomiting, chronic marijuana use, and compulsive bathing. We present a case of a 29-year-old man whose clinical presentation strongly correlates with cannabinoid hyperemesis syndrome. Despite a diagnosis of exclusion, this syndrome should be considered plausible in the setting of a patient with recurrent intractable vomiting and a strong history of cannabis use as presented in this case.

  11. Paradoxes of reading and knowledge in Slovenia

    Directory of Open Access Journals (Sweden)

    Miha Kovač

    2009-01-01

    Full Text Available The paper introduces the concept of book usage and puts Slovenian book usage into the context of the European Union. It stresses the limits of European book statistics,due to them the measurements of book usage in various European societies is almost impossible. In this context, we will show that due to available data, Slovenia paradoxically belongs to the countries with high book usage and average reading habits. In the second part of the paper, we will look at the correlations between reading habits and efficiency of education systems. On this basis, we will ask some new questions and develop a set of hypotheses that need to be verified by the further research.

  12. Dynamics in Braess Paradox with Nonimpulsive Commuters

    Directory of Open Access Journals (Sweden)

    Arianna Dal Forno

    2015-01-01

    the individual rationality leads to collective irrationality. In the literature, the dynamics has been analyzed when considering impulsive commuters, i.e., those who switch choice regardless of the actual difference between costs. We analyze a dynamical version of the paradox with nonimpulsive commuters, who change road proportionally to the cost difference. When only two roads are available, we provide a rigorous proof of the existence of a unique fixed point showing that it is globally attracting even if locally unstable. When a new road is added the system becomes discontinuous and two-dimensional. We prove that still a unique fixed point exists, and its global attractivity is numerically evidenced, also when the fixed point is locally unstable. Our analysis adds a new insight in the understanding of dynamics in social dilemma.

  13. The paradox of cognitive flexibility in autism.

    Science.gov (United States)

    Geurts, Hilde M; Corbett, Blythe; Solomon, Marjorie

    2009-02-01

    We present an overview of current literature addressing cognitive flexibility in autism spectrum disorders. Based on recent studies at multiple sites, using diverse methods and participants of different autism subtypes, ages and cognitive levels, no consistent evidence for cognitive flexibility deficits was found. Researchers and clinicians assume that inflexible everyday behaviors in autism are directly related to cognitive flexibility deficits as assessed by clinical and experimental measures. However, there is a large gap between the day-to-day behavioral flexibility and that measured with these cognitive flexibility tasks. To advance the field, experimental measures must evolve to reflect mechanistic models of flexibility deficits. Moreover, ecologically valid measures are required to be able to resolve the paradox between cognitive and behavioral inflexibility.

  14. [Paradox of Obesity and Cardiovascular Mortality].

    Science.gov (United States)

    Samorodskaja, I V; Bolotova, E V; Boytsov, S A

    2015-01-01

    Obesity is known as an independent risk factor of a number of chronic noninfectious disorders, however some investigations testify to the presence of "obesity paradox". The aim of the present review was to analyze results of investigations purposed to assess the effect of an elevated body mass index (BMI) and obesity on hospital mortality, risk of complications, and long term prognosis (mortality rate). Effect of BMI dynamics during lifespan on (cardiovascular ?) mortality was also analyzed. The results failed to demonstrate any convincing evidences that BMI 25-35 kg/m2 alone without taking into consideration metabolic changes, waist measurements, correlation between fat and muscular tissue was a risk factor of higher mortality in the long-term prospect and that its decrease improved survival. At the same time, it should be noted that these results depended on the method of sample formation and approaches to the statistical analysis.

  15. Aging and communication in the twin paradox

    Science.gov (United States)

    de Wolf, David A.

    2016-11-01

    The twin paradox of the special theory of relativity has given rize to a large body of literature discussing its implications. In its standard form, the traveler changes velocity only at the destination of the trip, so that he appears to perceive an improbably instantaneous and non-continuous change in age of the stationary twin. In this work, a smooth velocity/acceleration profile is used that allows the abrupt velocity-change case as a limit. All gravitational effects are ignored in this treatment. Aside from mutual perception of simultaneous clock times in an accelerating frame, constant communication of clock times between the twins by means of (digital) light signals is shown to be possible, in principle if not in practice.

  16. Aging and communication in the twin paradox

    CERN Document Server

    de Wolf, David A

    2016-01-01

    The twin paradox of the special theory of relativity has given rise to a large body of literature discussing its implications. In its standard form, the traveler changes velocity only at the destination of the trip, so that he appears to perceive an improbably instantaneous and non-continuous change in age of the stationary twin. In this work, a smooth velocity/acceleration profile is used that allows the abrupt velocity-change case as a limit. All gravitational effects are ignored in this treatment. Aside from mutual perception of simultaneous clock times in an accelerating frame, constant communication of clock times between the twins by means of (digital) light signals is shown to be possible, in principle if not in practice.

  17. Twin paradox in de Sitter spacetime

    Energy Technology Data Exchange (ETDEWEB)

    Boblest, Sebastian; Wunner, Guenter [Institut fuer Theoretische Physik, Universitaet Stuttgart, Pfaffenwaldring 57 IV, 70550 Stuttgart (Germany); Mueller, Thomas, E-mail: sebastian.boblest@itp1.uni-stuttgart.de, E-mail: Thomas.Mueller@vis.uni-stuttgart.de, E-mail: guenter.wunner@itp1.uni-stuttgart.de [Visualisierungsinstitut der Universitaet Stuttgart (VISUS), Allmandring 19, 70569 Stuttgart (Germany)

    2011-09-15

    The 'twin paradox' of special relativity offers the possibility of making interstellar flights within a lifetime. For very long journeys with velocities close to the speed of light, however, we have to take into account the expansion of the universe. Inspired by the work of Rindler on hyperbolic motion in curved spacetime, we study the worldline of a uniformly accelerated observer in de Sitter spacetime and the communication between the travelling observer and an observer at rest. This paper is intended to give graduate students who are familiar with special relativity and have some basic experience of general relativity a deeper insight into accelerated motion in general relativity, into the relationship between the proper times of different observers and the propagation of light signals between them, and into the use of compactification to describe the global structure of a relativistic model.

  18. [Euthanasia and the paradoxes of autonomy].

    Science.gov (United States)

    Siqueira-Batista, Rodrigo; Schramm, Fermin Roland

    2008-01-01

    The principle of respect for autonomy has proved very useful for bioethical arguments in favor of euthanasia. However unquestionable its theoretical efficacy, countless aporiae can be raised when conducting a detailed analysis of this concept, probably checkmating it. Based on such considerations, this paper investigates the principle of autonomy, starting with its origins in Greek and Christian traditions, and then charting some of its developments in Western cultures through to its modern formulation, a legacy of Immanuel Kant. The main paradoxes of this concept are then presented in the fields of philosophy, biology, psychoanalysis and politics, expounding several of the theoretical difficulties to be faced in order to make its applicability possible within the scope of decisions relating to the termination of life.

  19. The St. Petersburg paradox: An experimental solution

    Science.gov (United States)

    Da Silva, Sergio; Matsushita, Raul

    2016-03-01

    The St. Petersburg paradox refers to a gamble of infinite expected value, where people are likely to spend only a small entrance fee for it. There is a huge volume of literature that mostly concentrates on the psychophysics of the game; experiments are scant. Here, rather than focusing on the psychophysics, we offer an experimental, "physical" solution as if robots played the game. After examining the time series formed by one billion plays, we: confirm that there is no characteristic scale for this game; explicitly formulate the implied power law; and identify the type of α-stable distribution associated with the game. We find an α = 1 and, thus, the underlying distribution of the game is a Cauchy flight, as hinted by Paul Samuelson.

  20. Humanitarian Appeal and the Paradox of Power

    DEFF Research Database (Denmark)

    Vestergaard Jørgensen, Anne

    2013-01-01

    organizations to external demands, in terms of their choice of beneficiaries for public attention and in terms of the symbolic relations they set up between donors and beneficiaries. It is argued that this development is associated with a paradox of power and results in humanitarian organizations surrendering......Humanitarian organizations have in the past 10 years enjoyed immense support with their western publics. At the same time, however, the humanitarian sector is under increasing pressure from various sources, under scrutiny for its administration costs, its marketized practices and its alleged......, it draws out the most marked changes that can be observed in the mode of appeal employed during this period, with a view to understanding the impact of the changing conditions of existence of humanitarian organizations on their public appeal. The article exposes an increasing submission of humanitarian...

  1. EPR paradox, quantum nonlocality and physical reality

    Science.gov (United States)

    Kupczynski, M.

    2016-03-01

    Eighty years ago Einstein, Podolsky and Rosen demonstrated that instantaneous reduction of wave function, believed to describe completely a pair of entangled physical systems, led to EPR paradox. The paradox disappears in statistical interpretation of quantum mechanics (QM) according to which a wave function describes only an ensemble of identically prepared physical systems. QM predicts strong correlations between outcomes of measurements performed on different members of EPR pairs in far-away locations. Searching for an intuitive explanation of these correlations John Bell analysed so called local realistic hidden variable models and proved that correlations consistent with these models satisfy Bell inequalities which are violated by some predictions of QM and by experimental data. Several different local models were constructed and inequalities proven. Some eminent physicists concluded that Nature is definitely nonlocal and that it is acting according to a law of nonlocal randomness. According to these law perfectly random, but strongly correlated events, can be produced at the same time in far away locations and a local and causal explanation of their occurrence cannot be given. We strongly disagree with this conclusion and we prove the contrary by analysing in detail some influential finite sample proofs of Bell and CHSH inequalities and so called Quantum Randi Challenges. We also show how one can win so called Bell's game without violating locality of Nature. Nonlocal randomness is inconsistent with local quantum field theory, with standard model in elementary particle physics and with causal laws and adaptive dynamics prevailing in the surrounding us world. The experimental violation of Bell-type inequalities does not prove the nonlocality of Nature but it only confirms a contextual character of quantum observables and gives a strong argument against counterfactual definiteness and against a point of view according to which experimental outcomes are produced

  2. DDT and Malaria Prevention: Addressing the Paradox

    Science.gov (United States)

    Bouwman, Hindrik; van den Berg, Henk; Kylin, Henrik

    2011-01-01

    Background The debate regarding dichlorodiphenyltrichloroethane (DDT) in malaria prevention and human health is polarized and can be classified into three positions: anti-DDT, centrist-DDT, pro-DDT. Objective We attempted to arrive at a synthesis by matching a series of questions on the use of DDT for indoor residual spraying (IRS) with literature and insights, and to identify options and opportunities. Discussion Overall, community health is significantly improved through all available malaria control measures, which include IRS with DDT. Is DDT “good”? Yes, because it has saved many lives. Is DDT safe as used in IRS? Recent publications have increasingly raised concerns about the health implications of DDT. Therefore, an unqualified statement that DDT used in IRS is safe is untenable. Are inhabitants and applicators exposed? Yes, and to high levels. Should DDT be used? The fact that DDT is “good” because it saves lives, and “not safe” because it has health and environmental consequences, raises ethical issues. The evidence of adverse human health effects due to DDT is mounting. However, under certain circumstances, malaria control using DDT cannot yet be halted. Therefore, the continued use of DDT poses a paradox recognized by a centrist-DDT position. At the very least, it is now time to invoke precaution. Precautionary actions could include use and exposure reduction. Conclusions There are situations where DDT will provide the best achievable health benefit, but maintaining that DDT is safe ignores the cumulative indications of many studies. In such situations, addressing the paradox from a centrist-DDT position and invoking precaution will help design choices for healthier lives. PMID:21245017

  3. Avoiding Braess' Paradox Through Collective Intelligence

    Science.gov (United States)

    Wolpert , David H.; Tumer, Kagan

    1999-01-01

    In an Ideal Shortest Path Algorithm (ISPA), at each moment each router in a network sends all of its traffic down the path that will incur the lowest cost to that traffic. In the limit of an infinitesimally small amount of traffic for a particular router, its routing that traffic via an ISPA is optimal, as far as cost incurred by that traffic is concerned. We demonstrate though that in many cases, due to the side-effects of one router's actions on another routers performance, having routers use ISPA's is suboptimal as far as global aggregate cost is concerned, even when only used to route infinitesimally small amounts of traffic. As a particular example of this we present an instance of Braess' paradox for ISPA'S, in which adding new links to a network decreases overall throughput. We also demonstrate that load-balancing, in which the routing decisions are made to optimize the global cost incurred by all traffic currently being routed, is suboptimal as far as global cost averaged across time is concerned. This is also due to "side-effects", in this case of current routing decision on future traffic. The theory of COllective INtelligence (COIN) is concerned precisely with the issue of avoiding such deleterious side-effects. We present key concepts from that theory and use them to derive an idealized algorithm whose performance is better than that of the ISPA, even in the infinitesimal limit. We present experiments verifying this, and also showing that a machine-learning-based version of this COIN algorithm in which costs are only imprecisely estimated (a version potentially applicable in the real world) also outperforms the ISPA, despite having access to less information than does the ISPA. In particular, this COIN algorithm avoids Braess' paradox.

  4. The Epigenetic Paradox of Pluripotent ES Cells.

    Science.gov (United States)

    Festuccia, Nicola; Gonzalez, Inma; Navarro, Pablo

    2017-05-19

    The propagation and maintenance of gene expression programs are at the foundation of the preservation of cell identity. A large and complex set of epigenetic mechanisms enables the long-term stability and inheritance of transcription states. A key property of authentic epigenetic regulation is being independent from the instructive signals used for its establishment. This makes epigenetic regulation, particularly epigenetic silencing, extremely robust and powerful to lock regulatory states and stabilise cell identity. In line with this, the establishment of epigenetic silencing during development restricts cell potency and maintains the cell fate choices made by transcription factors (TFs). However, how more immature cells that have not yet established their definitive fate maintain their transitory identity without compromising their responsiveness to signalling cues remains unclear. A paradigmatic example is provided by pluripotent embryonic stem (ES) cells derived from a transient population of cells of the blastocyst. Here, we argue that ES cells represent an interesting "epigenetic paradox": even though they are captured in a self-renewing state characterised by extremely efficient maintenance of their identity, which is a typical manifestation of robust epigenetic regulation, they seem not to heavily rely on classical epigenetic mechanisms. Indeed, self-renewal strictly depends on the TFs that previously instructed their undifferentiated identity and relies on a particular signalling-dependent chromatin state where repressive chromatin marks play minor roles. Although this "epigenetic paradox" may underlie their exquisite responsiveness to developmental cues, it suggests that alternative mechanisms to faithfully propagate gene regulatory states might be prevalent in ES cells. Copyright © 2016 The Author(s). Published by Elsevier Ltd.. All rights reserved.

  5. Testing the potential paradoxes in "retrocausal" phenomena

    Science.gov (United States)

    Jolij, Jacob; Bierman, Dick J.

    2017-05-01

    Discussions with regard to potential paradoxes arising from "retrocausal" phenomena have been purely theoretical because so far no empirical effects had been established that allowed for empirical exploration of these potential paradoxes. In this article we describe three human experiments that showed clear "retrocausal" effects. In these neuropsychological, so-called, face-detection experiments, consisting of hundreds of trials per participant, we use brain signals to predict an upcoming random stimulus. The binary random decision, corresponding to showing a noisy cartoon face or showing only noise on a display with equal probability is taken after the brain signals have been measured. The prediction accuracy ranges from 50.5-56.5% for the 3 experiments where chance performance would be 50%. The prediction algorithm is based on a template constructed out of all the pre-stimulus brain signals obtained in other trials of that particular participant. This approach thus controls for individual difference in brain functioning. Subsequently we describe an experiment based upon these findings where the predictive information is used in part of the trials to determine the stimulus rather than randomly select that stimulus. In those trials we analyze what the brain signals tell us what the future stimulus would be and then we reverse the actual future that is presented on the display. This is a `bilking' condition. We analyze what the consequence of the introduction of this bilking condition is on the accuracy of the remaining (normal) trials and, following a suggestion inferred from Thorne et al, we also check what the effect is on the random decision to either bilk or not bilk the specific trial. The bilking experiment is in progress and the results so far do not allow for conclusions and are presented only as an illustration.

  6. The twin paradox in a cosmological context

    Science.gov (United States)

    Grøn, Ø.; Braeck, S.

    2011-09-01

    Recently Abramowicz and Bajtlik (arXiv:0905.2428 (2009)) have studied the twin paradox in Schwarzschild spacetime. Considering circular motion they showed that the twin with a non-vanishing 4-acceleration is older than his brother at the reunion and argued that, in spaces that are asymptotically Minkowskian, there exists an absolute standard of rest determining which twin is the oldest at the reunion. Here we show that with vertical motion in Schwarzschild spacetime the result is the opposite: The twin with a non-vanishing 4-acceleration is younger. We also deduce the existence of a new relativistic time effect, that there is either a time dilation or an increased rate of time associated with a clock moving in a rotating frame. This is in fact a first-order effect in the velocity of the clock, and must be taken into account if the situation presented by Abramowicz and Bajtlik is described from the rotating rest frame of one of the twins. Our analysis shows that this effect has a Machian character since the rotating state of a frame depends upon the motion of the cosmic matter due to the inertial dragging it causes. We argue that a consistent formulation and resolution of the twin paradox makes use of the general principle of relativity and requires the introduction of an extended model of the Minkowski spacetime. In the extended model Minkowski spacetime is supplied with a cosmic shell of matter with radius equal to its own Schwarzschild radius, so that there is perfect inertial dragging inside the shell.

  7. Paradoxical embolism: Experiences from a single center

    Directory of Open Access Journals (Sweden)

    Hong-Liang Zhang

    2017-06-01

    Full Text Available Objective: To present our treatment experiences and the follow-up data of patients with paradoxical embolism (PDE. Methods: The clinical characteristics, management, and follow-up data of all included patients who were diagnosed with PDE at Fuwai Hospital from January 1994 to October 2015 were recorded. Results: Twelve patients were included; all had a pulmonary embolism, and 8 had deep venous thrombosis. The artery embolisms involved the cerebral artery (7 patients, renal artery (2 patients, mesentery artery (2 patients, popliteal artery (1 patient, descending aorta thrombus (1 patient, and thrombus-straddled patent foramen ovale (PFO (1 patient. PFO was found in 3 cases. One patient underwent thrombectomy and PFO closure; Six patients received thrombolysis; and 3 patients were implanted with a vena cava filter. Long-term anticoagulation with warfarin was recommended for each patient. One patient died from ventricular fibrillation despite cardiopulmonary resuscitation. Eleven patients were discharged with improvements. No late mortality occurred in 8 patients with a complete follow-up of 10.6–17.7 years. One had a recurrent deep venous thrombosis. No patient had a recurrent pulmonary or arterial embolism. Two patients changed their treatment from warfarin to aspirin; others remained on warfarin. Only 1 case had an occasional gum bleeding. Conclusions: PDE treatment including thrombolysis, anticoagulation, and embolectomy should be individualized. We recommend long-term anticoagulation therapy to prevent the recurrence of PDE, especially to those with an intracardiac communication or persistent risk factors for re-thrombosis. Keywords: Paradoxical embolism, Pulmonary embolism, Deep venous thrombosis, Patent foramen ovale

  8. A "refugee paradox" for substance use disorders?

    Science.gov (United States)

    Salas-Wright, Christopher P; Vaughn, Michael G

    2014-09-01

    Few, if any, studies have systematically examined the link between nativity and substance use disorders (SUD) among refugees using national samples. As such, it remains uncertain if the "immigrant paradox" for substance use can be extended to include refugees in the United States. Employing data from the National Epidemiologic Survey on Alcohol and Related Conditions, we examine the lifetime prevalence of SUDs among refugees (n=428) in contrast with non-refugee immigrants (n=4955) and native-born Americans (n=29,267). We also examine the impact of gender and refugee duration on the relationship between nativity, refugee status, and SUDs. Refugees were between 3 and 6 times less likely than native-born Americans meet criteria for all SUDs examined, and significantly less likely than non-refugee immigrants to meet criteria for alcohol (AOR=0.44, 95% CI=0.41-0.47), cocaine (AOR=0.54, 95% CI=0.50-0.59), hallucinogen (AOR=0.66, 95% CI=0.58-0.74), and opioid/heroin (AOR=0.62, 95% CI=0.58-0.66) use disorders. The refugee-SUD link was significantly moderated by gender. Duration as a refugee was associated with increased risk for alcohol use disorder and decreased risk of cannabis and illicit drug use disorders. Study findings provide evidence in support of a "refugee paradox" for SUDs among adults in the United States. Refugees are substantially less likely than native-born Americans to meet criteria for all SUDs examined and, albeit with weaker effects, significantly less likely than non-refugee immigrants to meet criteria for a variety of SUDs. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  9. Linear perspective and framing in the vista paradox

    DEFF Research Database (Denmark)

    Costa, Marco; Bonetti, Leonardo

    2017-01-01

    The vista paradox is the illusion in which an object seen through a frame appears to shrink in apparent size as the observer approaches the frame. In four studies, we tested the effect of framing and fixating on the target object. The first two studies assessed the vista paradox in a large scale...... inserted within five frames differing in size. In the fourth study linear perspective was added to the images. The results showed that both frame size and linear perspective cues were critical factors for the vista paradox illusion....

  10. Linear optics implementation of weak values in Hardy's paradox

    Science.gov (United States)

    Ahnert, S. E.; Payne, M. C.

    2004-10-01

    We propose an experimental setup for the implementation of weak measurements in the context of the gedanken experiment known as Hardy’s paradox. As Aharonov et al. [Y. Aharonov, A. Botero, S. Popescu, B. Reznik, and J. Tollaksen, Phys. Lett. A301, 130 (2002)] showed, these weak values form a language with which the paradox can be resolved. Our analysis shows that this language is indeed consistent and experimentally testable. It also reveals exactly how a combination of weak values can give rise to an apparently paradoxical result.

  11. Reversal of a Suspected Paradoxical Reaction to Zopiclone with Flumazenil

    Directory of Open Access Journals (Sweden)

    Zarah Jordahn

    2016-01-01

    Full Text Available We describe the care for an elderly woman who was admitted to the intensive care unit (ICU to receive noninvasive ventilation for acute exacerbation of chronic obstructive pulmonary disease. After administration of the sleeping pill zopiclone, a nonbenzodiazepine receptor agonist (NBRA, the patient became agitated and was confused, a possible paradoxical reaction to benzodiazepines. These symptoms were immediately resolved after treatment with flumazenil, usually used to reverse the adverse effects of benzodiazepines or NBRAs and to reverse paradoxical reactions to benzodiazepines. This case indicates that zopiclone induced behavioral changes resembling a paradoxical reaction to benzodiazepines and these symptoms may be treated with flumazenil.

  12. The food-insecurity obesity paradox: A resource scarcity hypothesis.

    Science.gov (United States)

    Dhurandhar, Emily J

    2016-08-01

    Food insecurity is paradoxically associated with obesity in the United States. Current hypotheses to explain this phenomenon are descriptive regarding the low food security population's dietary and physical activity habits, but are not mechanistic. Herein it is proposed that a resource scarcity hypothesis may explain this paradox, such that fattening is a physiologically regulated response to threatened food supply that occurs specifically in low social status individuals. Evidence that this may be occurring, the implications for addressing the food insecurity-obesity paradox, and future areas of research, are reviewed and discussed. Copyright © 2016. Published by Elsevier Inc.

  13. Trapeziometacarpal Arthritis: A Prospective Clinical Evaluation of the Thumb Adduction and Extension Provocative Tests.

    Science.gov (United States)

    Gelberman, Richard H; Boone, Sean; Osei, Daniel A; Cherney, Steven; Calfee, Ryan P

    2015-07-01

    To determine the diagnostic performance (ie, sensitivity, specificity, interrater reliability) of the thumb metacarpal adduction and extension tests against traditional examination maneuvers for trapeziometacarpal (TMC) arthritis. This cross-sectional study recruited 129 patients from 2 outpatient offices at a tertiary institution. All patients had radiographic wrist examinations and completed a standardized physical examination consisting of the thumb adduction and extension tests as well as standard examination maneuvers for radial wrist and thumb pain. The physical examinations were performed by 1 of 2 attending physicians and an independent examiner. Patients were recruited for 3 diagnostic groups: TMC arthritis, radial wrist or hand pain, and nonradial wrist pain controls. Statistical analysis calculated the sensitivity, specificity, and interrater reliability of each physical examination maneuver for detecting TMC arthritis. The thumb adduction maneuver was found to have a sensitivity of 0.94 (confidence interval [CI], 0.82-0.98) and a specificity of 0.93 (CI, 0.86-0.97). The thumb extension maneuver had a sensitivity of 0.94 (CI, 0.82-0.98) and a specificity of 0.95 (CI, 0.87-0.98). The interrater reliability was excellent for both the adduction (κ = 0.79) and the extension tests (κ = 0.84). The grind test had a sensitivity of 0.44 (CI, 0.30-0.59), a specificity of 0.92 (CI, 0.84-0.97), and poor interrater reliability (0.31). Point tenderness at the TMC joint had a sensitivity of 0.94 (CI, 0.82-0.98), a specificity of 0.81 (CI, 0.71-0.88) and fair interrater reliability (κ = 0.63). The adduction and extension tests each proved to be more sensitive than the grind test for the detection of TMC arthritis. Further, these provocative tests were more specific for basal joint arthrosis than was the elicitation of point tenderness at the joint. The metacarpal adduction and extension maneuvers demonstrated excellent utility as screening tests for the

  14. Five-year major clinical outcomes according to severity of coronary artery spasm as assessed by intracoronary acetylcholine provocation test.

    Science.gov (United States)

    Kim, Yong Hoon; Her, Ae-Young; Rha, Seung-Woon; Choi, Byoung Geol; Shim, Minsuk; Choi, Se Yeon; Byun, Jae Kyeong; Li, Hu; Kim, Woohyeun; Kang, Jun Hyuk; Choi, Jah Yeon; Park, Eun Jin; Park, Sung Hun; Lee, Sunki; Na, Jin Oh; Choi, Cheol Ung; Lim, Hong Euy; Kim, Eung Ju; Park, Chang Gyu; Seo, Hong Seog; Oh, Dong Joo

    2017-10-10

    Long-term clinical outcome data according to severity of coronary artery spasm (CAS) as assessed by an intracoronary acetylcholine provocation test are limited in series of Asian patients. To investigate 5-year clinical outcomes in patients with CAS according to CAS severity. In total, 5873 consecutive patients with insignificant coronary artery disease (<70% fixed stenosis) who underwent an acetylcholine provocation test were enrolled and divided into four groups according to CAS severity during the acetylcholine provocation test: negative, borderline positive, moderately positive and severely positive. CAS severity was assessed by quantitative coronary angiography. We investigated 5-year clinical outcomes according to CAS severity. Over a follow-up period of up to 5 years, before adjustment, the severely-positive CAS group showed a significantly higher incidence of major adverse cardiac events (MACE; composite of death, myocardial infarction and de novo revascularization) (hazard ratio [HR]: 1.834, 95% confidence interval [CI]: 1.047-3.211; P=0.033), total death (HR: 3.124, 95% CI: 1.047-9.322; P=0.041), myocardial infarction (HR: 3.190, 95% CI: 1.069-9.519; P=0.037) and recurrent angina (HR: 1.762, 95% CI: 1.363-2.278; P<0.001) compared with the negative group. However, after adjustment for baseline confounders, only the incidence of recurrent angina (HR: 1.323, 95% CI: 1.014-1.726; P=0.039) was significantly higher in the severely-positive CAS group compared with the negative group. The severity of CAS in the positive group was not associated with an increased incidence of MACE after adjustment for covariates compared with the negative group, but the severely-positive CAS group was associated with a higher incidence of recurrent angina compared with the negative group. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  15. Effects of RF fields emitted from smart phones on cardio-respiratory parameters: a preliminary provocation study.

    Science.gov (United States)

    Kwon, Min Kyung; Nam, Ki Chang; Lee, Da Som; Jang, Kyung Hwan; Kim, Deok Won

    2011-01-01

    This paper describes an experimental setup for evaluating the physiological effects of radiofrequency (RF) emitted from a Wideband Code Division Multiple Access (WCDMA) module with a 24 dBm at 1950 MHz for specific absorption rate (SAR(1g)) of 1.57 W/kg. This provocation study was executed in a double-blind study of two volunteer groups of 10 self-reported electromagnetic hypersensitivity (EHS) and 10 non-EHS subjects under both sham and real exposures in a randomly assigned and counter-balanced order. In the preliminary results, WCDMA RF exposure of 30 min did not have any effects on physiological changes in either group.

  16. Paradoxical helminthiasis and giardiasis in Cape Town, South Africa ...

    African Journals Online (AJOL)

    Paradoxical helminthiasis and giardiasis in Cape Town, South Africa: epidemiology and control. Vera J Adams, Miles B Markus, Joanita FA Adams, Esme Jordaan, Bronwyn Curtis, Muhammad A Dhansay, Charlie C Obihara, John E Fincham ...

  17. THE PARADOX OF THE PLANKTON: COMMUNITY STRUCTURE PROMOTES BLOOMS

    Science.gov (United States)

    ABSTRACT: The 'paradox of the plankton' refers to commensalism as well as symbiosis, predation, and impacts of non equilibrium conditions between two planktoniccompetitors. In regards to commensalism, phytoplankton can release organic carbon that enhances growth of its ba...

  18. Speech Acts, Communicative Competence and the Paradox of Authority

    Science.gov (United States)

    McGuire, R. R.

    1977-01-01

    Attempts to resolve the paradox of authority through an expansion of the theory of speech acts by means of Habermas' theory of communicative competence. Cites the works of Robert Wolff and P.H. Nowell-Smith. (MH)

  19. One-Piece Faraday Generator: A Paradoxical Experiment from 1851

    Science.gov (United States)

    Crooks, M. J.; And Others

    1978-01-01

    Describes an experiment based on Faraday's one-piece generator, where the rotating disk is replaced by a cylindrical permanent magnet. Explains the apparent paradox that an observer in an inertial frame could measure his absolute velocity. (GA)

  20. Paradoxical Cerebral Fat Embolism in Revision Hip Surgery

    Directory of Open Access Journals (Sweden)

    Nicolás S. Piuzzi

    2014-01-01

    Full Text Available The incidence of clinical fat embolism syndrome (FES is low (<1% whilst fat embolism (FE of marrow fat appears to occur more often (Mellor and Soni (2001. Paradoxical brain FE may occur in patients undergoing hip orthopedic surgery who have an undocumented patent foramen ovale (PFO. We report a case of an eighty-year-old male patient, who underwent a scheduled revision hip surgery suffering a paradoxical cerebral FE.

  1. Paradoxes in virtual team knowledge communication and trust building

    OpenAIRE

    Petersen, Nils Braad

    2012-01-01

    This thesis proposal presents paradoxes within current trust and knowledge management literatures as a lens for understanding challenges in virtual teams working across organisational and geographic boundaries. By exposing contradictions within current virtual team research, the author proposes a need for a different, multi-level, multi-theoretical approach to virtual team research in order to overcome the paradoxes. A moderate constructionist research position building on Critical Realism is...

  2. The sociological significance of domestic violence: Tensions, paradoxes and implications

    OpenAIRE

    Hearn, Jeff

    2013-01-01

    Sociology and sociological theory has been effective in analyzing societal and institutional conflict and violence, but less so the specifics of interpersonal violence. This article examines the sociological significance of domestic violence. This relationship, or sometimes its neglect, is underlain by several tensions and paradoxes, which in turn have broader implications for sociology and sociological theory. These matters are examined through: the possible paradox of violence and intimacy ...

  3. Moving towards a geocentric, polycultural theory of organizational paradox

    OpenAIRE

    Keller, J; Lewis, M. W.

    2016-01-01

    Purpose\\ud This paper comments on “Global implications of the indigenous epistemological system from the east” (Li, 2016), which provides an indigenous Chinese perspective on organizational paradox. Li introduces Yin-Yang balancing as an epistemological system that can help scholars examine and practitioners manage paradoxes. In this commentary, the purpose of this paper is to discuss the merits of Yin-Yang balancing and how this approach and other indigenous theories might enrich organizatio...

  4. Paradoxical incontinence caused by "invisible dysplastic" kidneys: role of laparoscopy.

    Science.gov (United States)

    Dogra, P N; Prashad, R; Goel, Rajiu; Nabi, G; Ansari, M S

    2002-01-01

    A 35-year old female presented with paradoxical urinary incontinence. Examination under general anesthesia did not reveal any abnormality and cystoscopy showed absent right hemitrigone. Radiological and other renal imaging modalities revealed absent right kidney and normal functioning left kidney. Simultaneous localization and removal of small dysplastic right kidney was carried out by transperitoneal laparoscopy. Role of laparoscopy is emphasized in patients presenting with paradoxical urinary incontinence with no "visible" kidney/ureteric orifice on conventional evaluation.

  5. Use of paradox in the treatment of alcoholism.

    Science.gov (United States)

    Shore, J J

    1981-02-01

    Using a paradoxical approach in dealing with an alcoholic's denial of alcoholism and resistance to treatment allows the therapist to maintain an empathic stance while placing the responsibility for change on the alcoholic. The author discusses the theory of paradox, its use by Alcoholics Anonymous and Al-Anon, the power dynamics of the therapeutic process, and the specific strategies and ethics of this approach to therapy.

  6. Observation of the Braess Paradox in Electric Circuits

    Science.gov (United States)

    Nagurney, Ladimer; Nagurney, Anna

    User-optimized network systems may exhibit counterintuitive phenomena such as the Braess Paradox where, when adding an additional link to the network, the cost increases for every user. While traffic networks are a prime example of networks exhibiting this paradox, it has been observed in telecommunications networks and in physical networks such as mechanical spring, fluid flow, and nanoscale networks. This work demonstrates that the Braess Paradox occurs in macroscopic electric circuits consisting of only passive components: resistors and diodes. We identify the electrical quantities that correspond to the network flows and costs and illustrate the mapping of the cost functions to ideal components. We use the solution of the Kirchoff Law nodal equations to demonstrate that the Braess Paradox will be observed in the electrical network of ideal components. These nodal equations also predict that the Braess Paradox can be observed in networks implemented using real components. We construct several macroscopic electric circuits that represent different cost functions and show that the Braess Paradox occurs when the experimentally measured voltage across the circuit increases as an additional link is added. We conclude by extending this work to cases where the demand is varied.

  7. Immediate hypersensitivity to iodinated contrast media: diagnostic accuracy of skin tests and intravenous provocation test with low dose.

    Science.gov (United States)

    Sesé, L; Gaouar, H; Autegarden, J-E; Alari, A; Amsler, E; Vial-Dupuy, A; Pecquet, C; Francès, C; Soria, A

    2016-03-01

    The diagnosis of HSR to iodinated contrast media (ICM) is challenging based on clinical history and skin tests. This study evaluates the negative predictive value (NPV) of skin tests and intravenous provocation test (IPT) with low-dose ICM in patients with suspected immediate hypersensitivity reaction (HSR) to ICM. Thirty-seven patients with suspected immediate hypersensitivity reaction to ICM were included retrospectively. Skin tests and a single-blind placebo-controlled intravenous provocation test (IPT) with low-dose iodinated contrast media (ICM) were performed. Skin tests with ICM were positive in five cases (one skin prick test and five intradermal test). Thirty-six patients were challenged successfully by IPT, and only one patient had a positive challenge result, with a grade I reaction by the Ring and Messmer classification. Ten of 23 patients followed up by telephone were re-exposed to a negative tested ICM during radiologic examination; two experienced a grade I immediate reaction. For immediate hypersensitivity reaction to ICM, the NPV for skin tests and IPT with low dose was 80% (95% CI 44-97%). © 2016 John Wiley & Sons Ltd.

  8. The Paradox of Leisure in Later Life

    Science.gov (United States)

    Nimrod, Galit; Shrira, Amit

    2016-01-01

    Objective. Numerous studies have shown that involvement in leisure activity has a significant impact on older adults’ physical, psychological, social, and spiritual well-being. This study explores whether the association between leisure involvement and well-being in later life changes over time. Method. Data were drawn from the first 4 waves of the Survey of Health, Ageing, and Retirement in Europe (SHARE). Growth curve models were applied to examine whether leisure moderated change in quality of life (QoL) over time among 7,875 retirees aged 60 and older. Results. Findings indicated that the association between leisure and QoL increased with time, as nonactive respondents displayed a decline in QoL over time, whereas those with high levels of leisure involvement showed an increase. Findings remained significant after controlling for sociodemographics, health, and cognitive functioning. Discussion. Results indicated that the significance of leisure to well-being increases throughout the later life course, and that leisure may act as a resource for resilience in old age. They also pointed out a paradoxical situation in which the older seniors, who may benefit from leisure involvement more than their younger peers, are precisely the ones who face the greater number of constraints to beneficial use of leisure. PMID:25315158

  9. Marketing human organs: the autonomy paradox.

    Science.gov (United States)

    Marshall, P A; Thomasma, D C; Daar, A S

    1996-03-01

    The severe shortage of organs for transplantation and the continual reluctance of the public to voluntarily donate has prompted consideration of alternative strategies for organ procurement. This paper explores the development of market approaches for procuring human organs for transplantation and considers the social and moral implications of organ donation as both a "gift of life" and a "commodity exchange." The problematic and paradoxical articulation of individual autonomy in relation to property rights and marketing human body parts is addressed. We argue that beliefs about proprietorship over human body parts and the capacity to provide consent for organ donation are culturally constructed. We contend that the political and economic framework of biomedicine, in western and non-western nations, influences access to transplantation technology and shapes the form and development of specific market approaches. Finally, we suggest that marketing approaches for organ procurement are and will be negotiated within cultural parameters constrained by several factors: beliefs about the physical body and personhood, religious traditions, economic conditions, and the availability of technological resources.

  10. "Obesity paradox" in coronary artery disease.

    Science.gov (United States)

    Akin, Ibrahim; Nienaber, Christoph A

    2015-10-26

    Obesity used to be among the more neglected public health problems, but has unfolded as a growing medical and socioeconomic burden of epidemic proportions. Morbid obesity is linked to traditional cardiovascular risk factors like, hypertension, hyperlipidemia and diabetes, and suspected to incur increased morbidity and mortality in the Western and even third world populations. This patient cohort is also at greater risk to develop coronary artery disease. Recent population-based registries revealed that 43% and 24% of all cases of coronary revascularization were carried out in overweight and obese patients, respectively. However, despite evidence of a positive correlation between obesity and increased cardiovascular morbidity, some authors have described a better clinical outcome in overweight and obese patients, a phenomenon they coined "obesity paradoxon". Thus, there is an ongoing debate in light of conflicting data and the possibility of confounding bias causing misconception and challenging the "obesity paradox". In this review article we present the current evidence and throughly discuss the validity of the "obesity paradoxon" in a variety of clinical settings.

  11. Mad about Physics: Braintwisters, Paradoxes, and Curiosities

    Science.gov (United States)

    Jargodzki, Christopher; Potter, Franklin

    2000-11-01

    Why is there eight times more ice in Antarctica than in the Arctic? Why can you warm your hands by blowing gently, and cool your hands by blowing hard? Why would a pitcher scuff a baseball?Which weighs more-a pound of feathers or a pound of iron? Let science experts Christopher Jargodzki and Franklin Potter guide you through the curiosities of physics and you'll find the answers to these and hundreds of other quirky conundrums. You'll discover why sounds carry well over water (especially in the summer), how a mouse can be levitated in a magnetic field, why backspin is so important when shooting a basketball, and whether women are indeed as strong as men. With nearly 400 questions and answers on everything from race cars to jumping fleas to vanishing elephants, Mad about Physics presents a comprehensive collection of braintwisters and paradoxes that will challenge and entertain even the brainiest of science lovers. Whether you're a physicist by trade or just want to give your brain a power workout, this collection of intriguing and unusual physics challenges will send you on a highly entertaining ride that reveals the relevance of physics in our everyday lives.

  12. Science and midwifery: paradigms and paradoxes.

    Science.gov (United States)

    Kennedy, H P; Lowe, N K

    2001-01-01

    The everyday world of clinical practice is filled with paradigms and paradoxes that stem from the issues of who defines knowledge, how it is generated, and how the individual midwife applies it when providing care for women and families. Research useful for clinical practice should provide evidence to support scientific approaches (models) or strategies (interventions) in caring for women. In a clinical discipline, the answers to research questions should eventually inform clinical decision-making by providing practical clinical knowledge. This article presents an application of Stevenson's research steps for the development of clinically applicable knowledge that the midwife can use to analyze and evaluate research findings as a basis for practice decisions. Specific examples of midwifery research are used to illustrate each stage in the process and the circular nature of knowledge development. The challenge is to prepare midwives who can apply research findings skillfully using the best evidence to support clinical practice, as well as to groom midwife researchers who will develop systematic programs of relevant research about midwifery practice and outcomes.

  13. The Hispanic paradox in twin pregnancies.

    Science.gov (United States)

    Luke, Barbara; Brown, Morton B; Misiunas, Ruta B; Gonzalez-Quintero, Victor H; Nugent, Clark; van de Ven, Cosmas; Witter, Frank R; Newman, Roger B; D'Alton, Mary; Hankins, Gary D V; Grainger, David A; Macones, George A

    2005-10-01

    The objective of this study was to compare length of gestation, fetal growth, and birthweight by race/ethnicity and pregravid weight groups in twin pregnancies. Three thousand and thirty-six twin pregnancies of 28 weeks or more gestation were divided by race/ethnicity (White, Black and Hispanic), and pregravid body mass index (BMI) groups (less than 25.0 vs. 25.0 or more). Outcomes were modeled using multiple regression, controlling for confounders, with White non-Hispanic women as the reference group. Hispanic women had the highest average birthweight and the longest gestation, as well as the lowest proportions of low birthweight, very low birthweight, preterm and early preterm births of the 3 race/ethnicity groups. In the multivariate analyses, Hispanic women had significantly longer gestations (by 7.8 days) and faster rates of fetal growth midgestation (20 to 28 weeks, by 17.4 g/week) and late gestation (after 28 weeks, by 5.3 g/week), whereas Black women had significantly slower rates of fetal growth (by 5.7 g/week and by 4.5 g/week, respectively). These findings in twins reflect the racial and ethnic disparities previously shown in singletons, including the Hispanic paradox of longer gestations and higher rates of fetal growth.

  14. A cosmic solution to the twin paradox

    CERN Document Server

    Grøn, Ø

    2009-01-01

    Recently Abramowicz and Bajtlik [arXiv:0905.2428 (2009)] have studied the twin paradox in Schwarzschild spacetime. Considering circular motion they showed that the twin with a non-vanishing 4-acceleration is older than his brother at the reunion and argued that in spaces that are asymptotically Minkowskian there exists an absolute standard of rest determining which twin is oldest at the reunion. Here we show that with vertical motion in Schwarzschild spacetime the result is opposite: The twin with a non-vanishing 4-acceleration is younger. Moreover, by invoking the strong principle of relativity we also deduce the existence of a new relativistic time effect, that there is either a time dilation or an increased rate of time associated with a clock moving in a rotating frame. This is in fact a first order effect in the velocity of the clock, and must be taken into account if the situation presented by Abramowicz and Bajtlik is described from the rotating rest frame of one of the twins. Our analysis shows that t...

  15. Civil Society or Democracy? A Dutch Paradox

    Directory of Open Access Journals (Sweden)

    Remieg Aerts

    2010-01-01

    Full Text Available Since the 1990s, research has been carried out worldwide into the relationship between ‘civil society’ (an organised, self-aware society and the formation of democracy. Dutch historians have to date shown little interest in this field of research, although the case of the Netherlands is an interesting one, both historically and in terms of current affairs. This article makes a case for the relevance of Dutch history to the debate on civil society in relation to three points. Firstly, where civil society is a phenomenon of the eighteenth and above all the nineteenth centuries, the society of the Republic demonstrates that a corporatist order can show characteristics of a civil society. Secondly, the factor of religion can be an important element in the promotion of social commitment. Thirdly, Dutch history flags up a paradox: it seems that a highly developed, civil society can rather limit than promote the need for political democracy and the recognition of an independent political sphere.

  16. Harsh discipline and readiness for interpersonal aggression in Poland and the USA: the mediating role of sensitivity to provocations and frustrations

    Directory of Open Access Journals (Sweden)

    Dominiak-Kochanek Monika

    2015-12-01

    Full Text Available This study examined the effect of history of harsh parenting on readiness for aggression in young adults testing the mediating effect of emotional reaction to frustration and provocation that is assumed to arise in the context of a history of physical punishment and psychological aggression. Data were collected from 402 participants including 187 Poles (Mage = 9.5; SD = 1.2 and 215 Americans (Mage = 19.16, SD = 1.15. Participants reported retrospectively on corporal punishment and psychological aggression experienced during childhood. Based on self-report instruments, sensitivity to provocation and frustration and three patterns of readiness for aggression in adulthood were assessed. Contrary to the US sample, sensitivity to provocation and frustration were mediators in the Polish sample alone. The important role of contextual factors that define harsh parenting circumstances, such as cultural context and sex of the parent, are discussed.

  17. Paradoxic effects of metformin on endothelial cells and angiogenesis

    Science.gov (United States)

    Bruno, Antonino; Cantelmo, Anna R.; Albini, Adriana

    2014-01-01

    The biguanide metformin is used in type 2 diabetes management and has gained significant attention as a potential cancer preventive agent. Angioprevention represents a mechanism of chemoprevention, yet conflicting data concerning the antiangiogenic action of metformin have emerged. Here, we clarify some of the contradictory effects of metformin on endothelial cells and angiogenesis, using in vitro and in vivo assays combined with transcriptomic and protein array approaches. Metformin inhibits formation of capillary-like networks by endothelial cells; this effect is partially dependent on the energy sensor adenosine-monophosphate-activated protein kinase (AMPK) as shown by small interfering RNA knockdown. Gene expression profiling of human umbilical vein endothelial cells revealed a paradoxical modulation of several angiogenesis-associated genes and proteins by metformin, with short-term induction of vascular endothelial growth factor (VEGF), cyclooxygenase 2 and CXC chemokine receptor 4 at the messenger RNA level and downregulation of ADAMTS1. Antibody array analysis shows an essentially opposite regulation of numerous angiogenesis-associated proteins in endothelial and breast cancer cells including interleukin-8, angiogenin and TIMP-1, as well as selective regulation of angiopioetin-1, -2, endoglin and others. Endothelial cell production of the cytochrome P450 member CYP1B1 is upregulated by tumor cell supernatants in an AMPK-dependent manner, metformin blocks this effect. Metformin inhibits VEGF-dependent activation of extracellular signal-regulated kinase 1/2, and the inhibition of AMPK activity abrogates this event. Metformin hinders angiogenesis in matrigel pellets in vivo, prevents the microvessel density increase observed in obese mice on a high-fat diet, downregulating the number of white adipose tissue endothelial precursor cells. Our data show that metformin has an antiangiogenic activity in vitro and in vivo associated with a contradictory short

  18. Paradoxic effects of metformin on endothelial cells and angiogenesis.

    Science.gov (United States)

    Dallaglio, Katiuscia; Bruno, Antonino; Cantelmo, Anna R; Esposito, Alessia I; Ruggiero, Luca; Orecchioni, Stefania; Calleri, Angelica; Bertolini, Francesco; Pfeffer, Ulrich; Noonan, Douglas M; Albini, Adriana

    2014-05-01

    The biguanide metformin is used in type 2 diabetes management and has gained significant attention as a potential cancer preventive agent. Angioprevention represents a mechanism of chemoprevention, yet conflicting data concerning the antiangiogenic action of metformin have emerged. Here, we clarify some of the contradictory effects of metformin on endothelial cells and angiogenesis, using in vitro and in vivo assays combined with transcriptomic and protein array approaches. Metformin inhibits formation of capillary-like networks by endothelial cells; this effect is partially dependent on the energy sensor adenosine-monophosphate-activated protein kinase (AMPK) as shown by small interfering RNA knockdown. Gene expression profiling of human umbilical vein endothelial cells revealed a paradoxical modulation of several angiogenesis-associated genes and proteins by metformin, with short-term induction of vascular endothelial growth factor (VEGF), cyclooxygenase 2 and CXC chemokine receptor 4 at the messenger RNA level and downregulation of ADAMTS1. Antibody array analysis shows an essentially opposite regulation of numerous angiogenesis-associated proteins in endothelial and breast cancer cells including interleukin-8, angiogenin and TIMP-1, as well as selective regulation of angiopioetin-1, -2, endoglin and others. Endothelial cell production of the cytochrome P450 member CYP1B1 is upregulated by tumor cell supernatants in an AMPK-dependent manner, metformin blocks this effect. Metformin inhibits VEGF-dependent activation of extracellular signal-regulated kinase 1/2, and the inhibition of AMPK activity abrogates this event. Metformin hinders angiogenesis in matrigel pellets in vivo, prevents the microvessel density increase observed in obese mice on a high-fat diet, downregulating the number of white adipose tissue endothelial precursor cells. Our data show that metformin has an antiangiogenic activity in vitro and in vivo associated with a contradictory short

  19. The Paradox of Political Participation: Theorizing Uncivil Society

    Directory of Open Access Journals (Sweden)

    Klaus Eder

    2014-11-01

    Full Text Available The paper addresses the phenomenon of civil societies turning into uncivil societies and the capacity of civil societies for self-repair. Confronted with the recent events of the rise and fall of civil society in the “Arab Spring” and in the Ukrainian Maidan movement a conceptual framework is offered for accounting for such rise and fall. It starts with the paradox that participation in public debate equally produces civil and uncivil outcomes, thus taking up the classic thesis of the “fall of reason” formulated in the tradition of “critical theory” on the “dialectics of enlightenment”. Such “dialectics” results from the interplay of three mechanisms that shape the making of a civil society: the rule of law, the market and the forum. These mechanisms have their specific historical legacy in political and social philosophy. Civil society praised by some as the outcome of the rule of law, by others as the outcome of free markets and by others as the outcome of free speech, empirically does not stand up to these normative expectations. These mechanisms produce “perverse effects”, grasped by the metaphor of monsters representing the rule of law and the market: Leviathan (the perverse effects of the rule of law and Behemoth (the perverse of the market. These perverse effects cumulate in the emergence of uncivil society as the apotheosis of unreason. Fascism is a case for the perverse effects of public communication and political mobilization of people. After identifying the third monster, I will put forward the argument that the forum works not only as mechanism of repairing the rule of law and the market, but also as a “mechanism of self-repair” of civil so­ciety

  20. ADHD, Multimodal Treatment, and Longitudinal Outcome: Evidence, Paradox, and Challenge.

    Science.gov (United States)

    Hinshaw, Stephen P; Arnold, L Eugene

    2015-01-01

    Given major increases in the diagnosis of attention-deficit hyperactivity disorder (ADHD) and in rates of medication for this condition, we carefully examine evidence for effects of single versus multimodal (i.e., combined medication and psychosocial/behavioral) interventions for ADHD. Our primary data source is the Multimodal Treatment Study of Children with ADHD (MTA), a 14-month, randomized clinical trial in which intensive behavioral, medication, and multimodal treatment arms were contrasted with one another and with community intervention (treatment-as-usual), regarding outcome domains of ADHD symptoms, comorbidities, and core functional impairments. Although initial reports emphasized the superiority of well-monitored medication for symptomatic improvement, reanalyses and reappraisals have highlighted (a) the superiority of combination treatment for composite outcomes and for domains of functional impairment (e.g., academic achievement, social skills, parenting practices); (b) the importance of considering moderator and mediator processes underlying differential patterns of outcome, including comorbid subgroups and improvements in family discipline style during the intervention period; (c) the emergence of side effects (e.g., mild growth suppression) in youth treated with long-term medication; and (d) the diminution of medication's initial superiority once the randomly assigned treatment phase turned into naturalistic follow-up. The key paradox is that whereas ADHD clearly responds to medication and behavioral treatment in the short term, evidence for long-term effectiveness remains elusive. We close with discussion of future directions and a call for greater understanding of relevant developmental processes in the attempt to promote optimal, generalized, and lasting treatments for this important and impairing neurodevelopmental disorder.

  1. Basophil histamine release in the diagnosis of house dust mite and dander allergy of asthmatic children. Comparison between prick test, RAST, basophil histamine release and bronchial provocation.

    Science.gov (United States)

    Ostergaard, P A; Ebbesen, F; Nolte, H; Skov, P S

    1990-04-01

    The aim of the study is to compare the glass fibre-based basophil histamine release test with skin test (Phazet), RAST (Phadebas) and bronchial provocation test in children with allergic asthma. The study comprised 68 selected children with a case history of extrinsic allergic asthma to danders (cat and dog) and house-dust mite. Skin prick test, RAST, and histamine release were performed in all children and the bronchial provocation test was used as a reference of "true allergic asthma". A total of 81 allergen bronchial challenges were performed and 44 children experienced 49 positive provocations. In 2.9% (2/68) of the children histamine release could not be performed due to technical difficulties (low histamine release with anti-IgE). Concordances in the range 76-87% were observed with no significant difference between the tests. The highest concordance (87%) was found between histamine release and bronchial provocation test followed by skin prick test vs bronchial provocation (84%) and RAST vs bronchial provocation (80%). The sensitivity and specificity were calculated for each test. All tests showed sensitivities in the range 90-94% and no significant difference between them was observed. The specificity of histamine release, skin prick test, and RAST was 0.78, 0.69, and 0.63, respectively. The specificity of histamine release was better than RAST demonstrated by 95% confidence intervals. In conclusion, it was found that the histamine release test is a convenient diagnostic method and the study indicates a diagnostic value comparable to the common diagnostic methods in clinical allergy.

  2. [Effects and significance of methacholine bronchial provocation tests and salbutamol bronchial dilation test on measurements of fractional exhaled nitric oxide in patients with asthma].

    Science.gov (United States)

    Liu, Jielu; Yu, Huapeng; Tan, Xiaomei; Wu, Shuhan; Zhang, Pan; Fang, Zekui; Wang, Cuilan; He, Xi

    2016-03-01

    To study the effects and significance of methacholine (Mch) bronchial provocation tests and salbutamol bronchial dilation test on measurements of fractional exhaled nitric oxide (FeNO) in patients with asthma. This was a prospective study conducted between November 2014 and August 2015. A total of 135 patients with asthma visiting the respiratory clinic of Zhujiang Hospital were enrolled. The patients received either Mch bronchial provocation test or salbutamol bronchial dilation test based on their FEV1/FVC values and cooperative degree. Mch bronchial provocation test was performed by using Astograph Jupiter-21 (Astograh group) or APS-Pro airway reaction testing apparatus (APS group), and salbutamol bronchial dilation test was performed by using Jaeger spirometer (Dilation group). We compared the differences between FeNO values measured before examinations (Pre-FeNO) and 5 min after completion of these examinations (Post-FeNO). The geometric mean of Pre-FeNO and Post-FeNO was 28.07 ppb and 24.08 ppb respectively in the Astograh group, with a significant decrease of the FeNO value after the examination (Z=-3.093, P=0.002). A significant difference between Pre-FeNO and Post-FeNO was found in patients who had positive provocation results in the Astograh group (Z=-2.787, P=0.005), but not in the patients with negative results (Z=-1.355, P=0.176). The geometric mean of FeNO in the APS group decreased significantly from 27.95 ppb to 23.15 ppb after the examination was completed (Z=-5.170, P=0.000); both in patients with positive saline or Mch provocation results and in patients with negative provocation results, the differences between Pre-FeNO and Post-FeNO in the APS group being significant (Z=-2.705, -3.709, -2.371, P=0.002, 0.000, 0.018). No difference of FeNO change(ΔFeNO) was observed between the 2 Mch bronchial provocation test groups (Ubronchial dilation test has minor effect on the measurement of FeNO, but Mch bronchial provocation tests can significantly

  3. Quantum Bayesian networks with application to games displaying Parrondo's paradox

    Science.gov (United States)

    Pejic, Michael

    Bayesian networks and their accompanying graphical models are widely used for prediction and analysis across many disciplines. We will reformulate these in terms of linear maps. This reformulation will suggest a natural extension, which we will show is equivalent to standard textbook quantum mechanics. Therefore, this extension will be termed quantum. However, the term quantum should not be taken to imply this extension is necessarily only of utility in situations traditionally thought of as in the domain of quantum mechanics. In principle, it may be employed in any modelling situation, say forecasting the weather or the stock market---it is up to experiment to determine if this extension is useful in practice. Even restricting to the domain of quantum mechanics, with this new formulation the advantages of Bayesian networks can be maintained for models incorporating quantum and mixed classical-quantum behavior. The use of these will be illustrated by various basic examples. Parrondo's paradox refers to the situation where two, multi-round games with a fixed winning criteria, both with probability greater than one-half for one player to win, are combined. Using a possibly biased coin to determine the rule to employ for each round, paradoxically, the previously losing player now wins the combined game with probabilitygreater than one-half. Using the extended Bayesian networks, we will formulate and analyze classical observed, classical hidden, and quantum versions of a game that displays this paradox, finding bounds for the discrepancy from naive expectations for the occurrence of the paradox. A quantum paradox inspired by Parrondo's paradox will also be analyzed. We will prove a bound for the discrepancy from naive expectations for this paradox as well. Games involving quantum walks that achieve this bound will be presented.

  4. Genetic Susceptibility and Predictors of Paradoxical Reactions in Buruli Ulcer.

    Directory of Open Access Journals (Sweden)

    Yves Thierry Barogui

    2016-04-01

    Full Text Available Buruli ulcer (BU is the third most frequent mycobacterial disease in immunocompetent persons after tuberculosis and leprosy. During the last decade, eight weeks of antimicrobial treatment has become the standard of care. This treatment may be accompanied by transient clinical deterioration, known as paradoxical reaction. We investigate the incidence and the risks factors associated with paradoxical reaction in BU.The lesion size of participants was assessed by careful palpation and recorded by serial acetate sheet tracings. For every time point, surface area was compared with the previous assessment. All patients received antimicrobial treatment for 8 weeks. Serum concentration of 25-hydroxyvitamin D, the primary indicator of vitamin D status, was determined in duplex for blood samples at baseline by a radioimmunoassay. We genotyped four polymorphisms in the SLC11A1 gene, previously associated with susceptibility to BU. For testing the association of genetic variants with paradoxical responses, we used a binary logistic regression analysis with the occurrence of a paradoxical response as the dependent variable.Paradoxical reaction occurred in 22% of the patients; the reaction was significantly associated with trunk localization (p = .039 by Χ(2, larger lesions (p = .021 by Χ(2 and genetic factors. The polymorphisms 3'UTR TGTG ins/ins (OR 7.19, p < .001 had a higher risk for developing paradoxical reaction compared to ins/del or del/del polymorphisms.Paradoxical reactions are common in BU. They are associated with trunk localization, larger lesions and polymorphisms in the SLC11A1 gene.

  5. Obesity paradox in end-stage kidney disease patients.

    Science.gov (United States)

    Park, Jongha; Ahmadi, Seyed-Foad; Streja, Elani; Molnar, Miklos Z; Flegal, Katherine M; Gillen, Daniel; Kovesdy, Csaba P; Kalantar-Zadeh, Kamyar

    2014-01-01

    In the general population, obesity is associated with increased cardiovascular risk and decreased survival. In patients with end-stage renal disease (ESRD), however, an "obesity paradox" or "reverse epidemiology" (to include lipid and hypertension paradoxes) has been consistently reported, i.e. a higher body mass index (BMI) is paradoxically associated with better survival. This survival advantage of large body size is relatively consistent for hemodialysis patients across racial and regional differences, although published results are mixed for peritoneal dialysis patients. Recent data indicate that both higher skeletal muscle mass and increased total body fat are protective, although there are mixed data on visceral (intra-abdominal) fat. The obesity paradox in ESRD is unlikely to be due to residual confounding alone and has biologic plausibility. Possible causes of the obesity paradox include protein-energy wasting and inflammation, time discrepancy among competitive risk factors (undernutrition versus overnutrition), hemodynamic stability, alteration of circulatory cytokines, sequestration of uremic toxin in adipose tissue, and endotoxin-lipoprotein interaction. The obesity paradox may have significant clinical implications in the management of ESRD patients especially if obese dialysis patients are forced to lose weight upon transplant wait-listing. Well-designed studies exploring the causes and consequences of the reverse epidemiology of cardiovascular risk factors, including the obesity paradox, among ESRD patients could provide more information on mechanisms. These could include controlled trials of nutritional and pharmacologic interventions to examine whether gain in lean body mass or even body fat can improve survival and quality of life in these patients. © 2014.

  6. Paradoxical monocular stereopsis and perspective vergence

    Science.gov (United States)

    Enright, J. T.

    1989-01-01

    The question of how to most effectively convey depth in a picture is a multifaceted problem, both because of potential limitations of the chosen medium (stereopsis, image motion), and because effectiveness can be defined in various ways. Practical applications usually focus on information transfer, i.e., effective techniques for evoking recognition of implied depth relationships, but this issue depends on subjective judgements which are difficult to scale when stimuli are above threshold. Two new approaches to this question are proposed here which are based on alternative criteria for effectiveness. Paradoxical monocular stereopsis is a remarkably compelling impression of depth which is evoked during one-eyed viewing of only certain illustrations; it can be unequivocally recognized because the feeling of depth collapses when one shifts to binocular viewing. An exploration of the stimulus properties which are effective for this phenomenon may contribute useful answers for the more general perceptual problem. Positive vergence is an eye-movement response associated with changes of fixation point within a picture which implies depth; it also arises only during monocular viewing. The response is directionally appropriate (i.e., apparently nearer objects evoke convergence, and vice versa), but the magnitude of the response can be altered consistently by making relatively minor changes in the illustration. The cross-subject agreement in changes of response magnitude would permit systematic exploration to determine which stimulus configurations are most effective in evoking perspective vergence, with quantitative answers based upon this involuntary reflex. It may well be that most effective pictures in this context will embody features which would increase effectiveness of pictures in a more general sense.

  7. Embolia paradojal inminente Impending paradoxical embolism

    Directory of Open Access Journals (Sweden)

    Miguel A. Veltri

    2006-12-01

    Full Text Available La presencia de un trombo venoso atrapado en un defecto interauricular e insinuándose en las cavidades izquierdas configura una forma extremadamente inusual de enfermedad tromboembólica denominada embolia paradojal inminente. Presentamos el caso de un varón de 71 años, sometido 10 días antes a adenomectomía prostática, que consultó por disnea y mareos. Se le diagnosticó tromboembolismo pulmonar bilateral por tomografía axial computada helicoidal. Se lo anticoaguló con heparina sódica y se le realizó un ecocardiograma transesofágico que mostró un trombo que atravesaba el foramen oval y se alojaba en la aurícula izquierda. No presentaba signos clínicos de embolización sistémica. Se realizó la embolectomía quirúrgica y cierre del defecto auricular. El paciente falleció.An intracardiac thrombus traversing a patent foramen ovale is a very infrequent but potentially catastrophic complication of the thromboembolic disease. It is named "impending paradoxical embolism". We report the case of a 71 year old Caucasian male warded in ten days after a prostatectomy because of bilateral pulmonary embolism. Diagnosis was confirmed by HCT scan and the patient received anticoagulation with heparin. A transesophageal ecocardiogram disclosed a thrombus traversing foramen ovale into the left atrium. Surgical embolectomy was performed, but the patient died shortly after surgery.

  8. Innovation Paradox in Vaccine Target Selection

    NARCIS (Netherlands)

    E.S. Pronker (Esther)

    2013-01-01

    textabstractPublic health is continually threatened by re- and newly emerging infections, as well as pathogen resistance to available intervention strategies, including vaccines. This persistent threat of the unmet medical need challenges vaccine developers to anticipate future epidemiological

  9. Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation.

    Directory of Open Access Journals (Sweden)

    Susanna L Lundström

    Full Text Available Asthma is a respiratory tract disorder characterized by airway hyper-reactivity and chronic inflammation. Allergic asthma is associated with the production of allergen-specific IgE and expansion of allergen-specific T-cell populations. Progression of allergic inflammation is driven by T-helper type 2 (Th2 mediators and is associated with alterations in the levels of lipid mediators.Responses of the respiratory system to birch allergen provocation in allergic asthmatics were investigated. Eicosanoids and other oxylipins were quantified in the bronchoalveolar lumen to provide a measure of shifts in lipid mediators associated with allergen challenge in allergic asthmatics.Eighty-seven lipid mediators representing the cyclooxygenase (COX, lipoxygenase (LOX and cytochrome P450 (CYP metabolic pathways were screened via LC-MS/MS following off-line extraction of bronchoalveolar lavage fluid (BALF. Multivariate statistics using OPLS were employed to interrogate acquired oxylipin data in combination with immunological markers.Thirty-two oxylipins were quantified, with baseline asthmatics possessing a different oxylipin profile relative to healthy individuals that became more distinct following allergen provocation. The most prominent differences included 15-LOX-derived ω-3 and ω-6 oxylipins. Shared-and-Unique-Structures (SUS-plot modeling showed a correlation (R(2 = 0.7 between OPLS models for baseline asthmatics (R(2Y[cum] = 0.87, Q(2[cum] = 0.51 and allergen-provoked asthmatics (R(2Y[cum] = 0.95, Q(2[cum] = 0.73, with the majority of quantified lipid mediators and cytokines contributing equally to both groups. Unique structures for allergen provocation included leukotrienes (LTB(4 and 6-trans-LTB(4, CYP-derivatives of linoleic acid (epoxides/diols, and IL-10.Differences in asthmatic relative to healthy profiles suggest a role for 15-LOX products of both ω-6 and ω-3 origin in allergic inflammation. Prominent differences at baseline levels indicate

  10. Fermi's Paradox Is a Daunting Problem---Under Whatever Label

    CERN Document Server

    Cirkovic, Milan M

    2016-01-01

    Gray (2015) argued that the Fermi paradox (FP) is a misnomer, and it is not a valid paradox. Gray also speculated that the argument was misattributed to Fermi, whose lunchtime remarks did not pertain to the existence of extraterrestrial intelligence, but to the feasibility of interstellar travel. Instead, the paradox is ascribed to Hart and Tipler, and it is further suggested that the paradox is not a real problem or research subject and should not be used in debates about SETI projects. The arguments given are unpersuasive, ahistorical, and, in at least one instance, clearly hinge on literalistic and uncharitable reading of evidence. Instead, I argue the following three points: (i) Contrary to Gray's assertion, the historical issue of naming of ideas or concepts is completely divorced from their epistemic status. (ii) FP is easily and smoothly generalized into the Great Silence paradox, so it makes no sense either theoretically or empirically to separate the two. (iii) In sharp contrast to the main implicati...

  11. The diagnostic value of three sacroiliac joint pain provocation tests for sacroiliitis identified by magnetic resonance imaging

    DEFF Research Database (Denmark)

    Arnbak, B; Jurik, A G; Jensen, R K

    2017-01-01

    was 33 (range 18-40) years and 241 (53%) were women. The prevalence of SI joints with sacroiliitis was 5%. In the whole study group, only the thigh trust test was associated with sacroiliitis, the area under the receiver operating characteristic (ROC) curve (AUC) was 0.58 [95% confidence interval (CI) 0......OBJECTIVES: The aim of the current study was to investigate the diagnostic value of three sacroiliac (SI) joint pain provocation tests for sacroiliitis identified by magnetic resonance imaging (MRI) and stratified by gender. METHOD: Patients without clinical signs of nerve root compression were.......51-0.65], sensitivity 31% (95% CI 18-47), and specificity 85% (95% CI 82-87). In men, sacroiliitis was associated with all the SI joint tests assessed and multi-test regimens, with the greatest AUC found for at least one positive out of three tests [AUC 0.68 (95% CI 0.56-0.80), sensitivity 56% (95% CI 31...

  12. Behaviour on the nasal provocation test in patients affected by conjunctivitis and/or asthma of allergic origin.

    Science.gov (United States)

    Filiaci, F; Lucarelli, N

    1981-09-01

    In the Allergo-Immunological Centre of Rome University we selected 120 patients of both sexes, ranging from 5-65 years of age, affected by asthma and/or conjunctivitis without past or present history of nasal impairment (itching, sneezing, hydrorrhea). As a result of the allergometric tests carried out, the authors divided the samples into three groups: 1) positive reaction to Dermatophagoides Pteronissimus (66.6%); 2) positive reaction to the Graminacee (28.3%); 3) positive reaction to Parietaria officinalis (5.1%). After having undergone the rhinoreomanometric test of nasal provocation, 50% of the patients revealed a positive reaction to the specific allergen, more specifically at 50 PNU/ml 40% of the case were positive, and at 100 PNU/ml 50% were positive. These results are discussed in the light of modern biological knowledge on the mastocytes in normal subjects and in those suffering from allergy.

  13. Four twins for a paradox: on "sensitive" twins and the biological counterpart of the "twin paradox".

    Science.gov (United States)

    Ascioti, Fortunato A

    2009-03-01

    Monozygotic twin (MZT) epigenetic development, i.e., aging, diverges largely in time despite the initially very small genetic differences between MZTs. This fact is interpreted as a "sensitivity to initial conditions" phenomenon, a common property of either deterministic or stochastic chaotic systems. Some of the biotheoretical implications stemming from this empirical observation are briefly discussed here, while an actual measure of MZT epigenetic time divergence is given through an estimate of the (Stochastic) Lyapunov exponents (LEs) (i.e., the rate of exponential time divergence). These results suggest a reconsideration of the Langevin-Einstein thought experiment known as the "twin paradox." At least four twins are necessary in order to take into account the inertially independent divergent aging described here. Alternatively, LE estimates, like those given here, should be used. Finally suggested in the actual special-relativity experiments is the replacement of clocks with some nonlinear (chaotic) forced oscillator.

  14. Four twins for a paradox: On ``sensitive'' twins and the biological counterpart of the ``twin paradox''

    Science.gov (United States)

    Ascioti, Fortunato A.

    2009-03-01

    Monozygotic twin (MZT) epigenetic development, i.e., aging, diverges largely in time despite the initially very small genetic differences between MZTs. This fact is interpreted as a "sensitivity to initial conditions" phenomenon, a common property of either deterministic or stochastic chaotic systems. Some of the biotheoretical implications stemming from this empirical observation are briefly discussed here, while an actual measure of MZT epigenetic time divergence is given through an estimate of the (Stochastic) Lyapunov exponents (LEs) (i.e., the rate of exponential time divergence). These results suggest a reconsideration of the Langevin-Einstein thought experiment known as the "twin paradox." At least four twins are necessary in order to take into account the inertially independent divergent aging described here. Alternatively, LE estimates, like those given here, should be used. Finally suggested in the actual special-relativity experiments is the replacement of clocks with some nonlinear (chaotic) forced oscillator.

  15. Traversing boundaries: thrombus in transit with paradoxical embolism

    Directory of Open Access Journals (Sweden)

    Varun Miriyala

    2016-09-01

    Full Text Available A 72-year-old male is diagnosed with paradoxical embolus after he presented with concurrent deep vein thrombosis, stroke, and multiple arterial emboli in the presence of a patent foramen ovale (PFO. Paradoxical embolus requires the passage of a thrombus from the venous into the arterial circulation through a right-to-left shunt leading to systemic embolism. But, despite the high incidence of PFO (27.3% across all age groups by autopsy, paradoxical embolism (PDE is uncommon, representing <2% of all arterial emboli. We present a case report where a thrombus has been directly observed passing through the PFO during an echocardiogram study; thus, clearly delineating the true cause of multiple thromboemboli and stoke in our patient. Subsequent Transesophageal Echocardiography (TEE also interestingly showed the thrombus in transit in the aorta and pulmonary artery.

  16. Einstein-Podolsky-Rosen paradox in single pairs of images.

    Science.gov (United States)

    Lantz, Eric; Denis, Séverine; Moreau, Paul-Antoine; Devaux, Fabrice

    2015-10-05

    Spatially entangled twin photons provide a test of the Einstein-Podolsky-Rosen (EPR) paradox in its original form of position (image plane) versus impulsion (Fourier plane). We show that recording a single pair of images in each plane is sufficient to safely demonstrate an EPR paradox. On each pair of images, we have retrieved the fluctuations by subtracting the fitted deterministic intensity shape and then have obtained an intercorrelation peak with a sufficient signal to noise ratio to safely distinguish this peak from random fluctuations. A 95% confidence interval has been determined, confirming a high degree of paradox whatever the considered single pairs. Last, we have verified that the value of the variance of the difference between twin images is always below the quantum (poissonian) limit, in order to ensure the particle character of the demonstration. Our demonstration shows that a single image pattern can reveal the quantum and non-local behavior of light.

  17. The Colombian Left: A Paradoxical Past; A Promising Future?

    Directory of Open Access Journals (Sweden)

    Charles Bergquist

    2017-07-01

    Full Text Available The essay explores the paradoxical history of the left in Colombia: how and why one of the weakest lefts in Latin America brought about the strongest and most lasting Marxist insurrection in the hemisphere in the decades following the Cuban Revolution. The article argues that the terms of this paradox are related, that the historic weakness of the left partly explains the force and longevity of revolutionary guerrillas, and that said paradox helps clarify not only the failure of several attempts to achieve a negotiated settlement of the armed conflict, but also the negative vote in the October 2016 plebiscite. Finally, it envisions a more promising future for the country’s left, provided that a lasting peace is consolidated.

  18. Paradoxes in virtual team knowledge communication and trust building

    DEFF Research Database (Denmark)

    Petersen, Nils Braad

    2012-01-01

    This thesis proposal presents paradoxes within current trust and knowledge management literatures as a lens for understanding challenges in virtual teams working across organisational and geographic boundaries. By exposing contradictions within current virtual team research, the author proposes...... a need for a different, multi-level, multi-theoretical approach to virtual team research in order to overcome the paradoxes. A moderate constructionist research position building on Critical Realism is proposed. To situate the project within current literatures, trust, knowledge management and virtual...... team literatures are reviewed. These are used to support the paradoxes used as a lens for understanding. A research design is presented building on interviews, documentary analysis and observations analysed using Social Network Analysis and James Gee’s framework for discourse analysis. Finally...

  19. A Contextual Risk Model for the Ellsberg Paradox

    CERN Document Server

    Aerts, Diederik

    2011-01-01

    The Allais and Ellsberg paradoxes show that the expected utility hypothesis and Savage's Sure-Thing Principle are violated in real life decisions. The popular explanation in terms of 'ambiguity aversion' is not completely accepted. On the other hand, we have recently introduced a notion of 'contextual risk' to mathematically capture what is known as 'ambiguity' in the economics literature. Situations in which contextual risk occurs cannot be modeled by Kolmogorovian classical probabilistic structures, but a non-Kolmogorovian framework with a quantum-like structure is needed. We prove in this paper that the contextual risk approach can be applied to the Ellsberg paradox, and elaborate a 'sphere model' within our 'hidden measurement formalism' which reveals that it is the overall conceptual landscape that is responsible of the disagreement between actual human decisions and the predictions of expected utility theory, which generates the paradox. This result points to the presence of a 'quantum conceptual layer'...

  20. Dumping symptoms and incidence of hypoglycaemia after provocation test at 6 and 12 months after laparoscopic sleeve gastrectomy.

    Science.gov (United States)

    Papamargaritis, Dimitris; Koukoulis, George; Sioka, Eleni; Zachari, Eleni; Bargiota, Alexandra; Zacharoulis, Dimitris; Tzovaras, George

    2012-10-01

    A previous study has demonstrated that symptoms suggestive of dumping syndrome appear after a provocation test early after laparoscopic sleeve gastrectomy (LSG) in 45 % of patients, and these are mainly related to early dumping. The aim of this study is to evaluate the evolution of dumping symptoms during the first postoperative year. Twenty-five non-diabetic morbidly obese patients (6 male, 19 female) were evaluated with an oral glucose tolerance test (OGTT) preoperatively, at 6 weeks and at 6 months postoperatively. In addition, 12 of them repeated the OGTT at 12 months after LSG. Sigstad score was used to separate dumpers from non-dumpers and Arts' questionnaire to differentiate between early and late dumping. Insulin and glucose levels were also measured. Sigstad score remained significantly elevated at 6 and 12 months postoperatively compared to preoperative values. Symptoms suggestive of dumping syndrome were recorded in 40 % of patients at 6 months and in 33 % at 12 months postoperatively. Arts' questionnaire demonstrated that early dumping score remained higher compared to baseline at 6 and 12 months postoperatively. Late dumping scores increased gradually during the time and that difference was statistically significant at 12 months after LSG. Hypoglycaemia occurred at 33 % of patients both at 6 and 12 months postoperatively. Symptoms suggestive of dumping syndrome after provocation still exist at 6 and 12 months in a significant proportion of patients after LSG and include both early and late dumping. These findings are consistent with the high incidence of hypoglycaemia after OGTT at 6 and 12 months after LSG.

  1. FCJ-161 Productive Provocations: Vitriolic Media, Spaces of Protest and Agonistic Outrage in the 2011 England Riots

    Directory of Open Access Journals (Sweden)

    Anthony McCosker

    2013-12-01

    Full Text Available The intense social upheaval that spread through a number of UK cities in the riots and protests of August, 2011 signalled the terrifying speed with which passionate disaffection can turn to uncontained violence. At stake in the dense and volatile debate that ensued, and in the acts of violence themselves, were contests over spaces as well as competing models of democracy, publics and citizenship, including the appropriate use of social media. Within these debates, almost universally, rational deliberative discourse and action is assumed to be the only route to legitimate “civil” society. So what is to be made of the violent physical contest over city squares, streets and property, as well as contests over acts of participation and demonstration played out online through the hundreds of eyewitness videos posted to sites like YouTube and the endless flow of often vitriolic words in blogs, comments spaces and social network sites? This paper uses a video posted to YouTube titled ‘Clapham Junction Speaker (London Riots 2011’ to examine the passion and provocation that flowed beyond the city streets to enliven, intensify and sustain forms of protest and civic engagement. We argue that the aggressive and antagonistic tenor of the Speaker’s twenty minute monologue, the bitter vitriol that flowed through the comments space, and even the act of posting it constitute significant elements of a generative, ‘agonistic’ public, to use Chantal Mouffe’s term, that operates in multiple spaces and outside of the rationalising discourse demanded by mainstream media and government. This paper develops a richer understanding of these spaces of protest, and the concept of provocation central to these events.

  2. Avoidance of nonsteroidal anti-inflammatory drugs after negative provocation tests in urticaria/angioedema reactions: Real-world experience.

    Science.gov (United States)

    Bommarito, Luisa; Zisa, Giuliana; Riccobono, Francesca; Villa, Elisa; D'Antonio, Cristian; Calamari, Ambra M; Poppa, Mariangela; Moschella, Adele; Di Pietrantonj, Carlo; Galimberti, Maurizio

    2014-01-01

    Drug provocation tests (DPTs) are the gold standard in diagnosing nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity; however, only few data about follow-up of patients with negative DPTs are actually available. The aim of this study was to assess patients' behavior in taking NSAIDs again and to evaluate NSAID tolerability after negative allergological workup. This is a follow-up study involving patients evaluated for history of cutaneous reactions (urticaria and or angioedema) after NSAID intake and with negative DPTs with the suspected NSAID. Patients were asked during a phone interview about the intake of NSAIDs, tolerance, or reasons of avoidance. The negative predictive value (NPV) of NSAIDs DPTs was calculated. One hundred eleven of 142 patients were successfully contacted; 46/111 (41.44%) took the same NSAID previously tested with two adverse reactions reported (4.34%). Fifty-three of 111 (47.74%) patients did not take the same NSAID, but 34 of them took at least another strong cyclooxygenase (COX) 1 inhibitor, with 1 adverse reaction (2.94%) and 19 of them took only weak COX-1 inhibitors. Twelve of 111 patients (10.8%) did not take any NSAID. Reasons for drug avoidance were mainly fear of reactions (70.8%) and no need (29.2%). NPV, overall, was 96.97% (95% confidence interval, 91-99%). Although NSAID hypersensitivity diagnosis was ruled out by oral provocation test, the majority of patients with a history of urticaria/angioedema avoided the intake of the tested NSAIDs for fear of new reactions, particularly when strong COX-1 inhibitor NSAIDs were involved. The high NPV value of DPT resulting from this study should reassure NSAID intake.

  3. Individual differences in cognitive reappraisal usage modulate the time course of brain activation during symptom provocation in specific phobia

    Science.gov (United States)

    2013-01-01

    Background Extinction learning is proposed to be one key mechanism of action underlying exposure-based cognitive-behavioral therapy (CBT) in specific phobia. Beyond that, cognitive reappraisal, one important strategy to regulate negative emotions, is a crucial component of CBT interventions, but has been disregarded in previous studies investigating neural change processes in specific phobia. The aim of this study was to investigate the association of individual differences in habitual/dispositional cognitive reappraisal usage and the time course of brain activation during phobic stimulation in specific phobia. Methods Dental phobic patients and healthy control subjects participated in a functional magnetic resonance imaging (fMRI) study whilst being confronted with phobic, disgust, fear and neutral pictures. Individual differences in cognitive reappraisal usage were assessed via a self-report questionnaire and correlated with activation decreases over the course of time. Results Phobic individuals with higher dispositional cognitive reappraisal scores showed a more pronounced activation decline in the right dorsomedial prefrontal cortex (dmPFC) which might be associated with a diminution of explicit cognitive emotion regulation over the course of time. Less decrease of activation in the right ventromedial prefrontal cortex (vmPFC) and the lateral orbitofrontal cortex (lOFC) over time in subjects with higher cognitive reappraisal scores might be related to a stronger automatic regulation of emotions or even emotional relearning. Additionally, phobic subjects compared with healthy controls showed a stronger habituation of the left dmPFC over the course of symptom provocation. Conclusions The results of this study show for the first time that individual differences in cognitive reappraisal usage are associated with the time course of brain activation during symptom provocation in specific phobia. Additionally, the present study gives first indications for the

  4. MAOA-uVNTR genotype predicts interindividual differences in experimental aggressiveness as a function of the degree of provocation.

    Science.gov (United States)

    Kuepper, Yvonne; Grant, Phillip; Wielpuetz, Catrin; Hennig, Juergen

    2013-06-15

    The MAOA-uVNTR has been suggested to play a role regarding aggression, however, results are inconsistent. We aimed at further elucidating potential effects of the MAOA-uVNTR on aggressiveness with respect to potential modulators: sex, experimental vs. trait aggressiveness and type of aggressiveness (proactive vs. reactive aggressiveness). We tested 239 healthy young adults (88 men/151 women). Participants were genotyped for the MAOA-uVNTR and performed a modified version of a competitive reaction time task - a commonly used and well established tool to elicit and measure aggressiveness. Furthermore, they completed a self-report scale measuring trait aggressiveness. We found a main effect of MAOA-uVNTR on a measure of reactive aggressiveness for both men and women, whereby the low-activity alleles of the MAOA-uVNTR were associated with substantially increased aggressive reactions (paggressiveness. Measures of proactive aggressiveness or self reports were not associated with the MAOA-uVNTR-genotype. Our data are in line with earlier studies and indicate the MAOA-uVNTR-genotype to be specifically associated with measures of reactive impulsive experimental aggressiveness in healthy men and women. Furthermore the association between the MAOA-uVNTR genotype and aggressive responses increases in a fashion linear to the degree of provocation. This indicates that the low-functional alleles of the MAOA-uVNTR are not associated with increased aggressive behavior per se, but rather with an increased aggressive reactivity to provocation. Copyright © 2013 Elsevier B.V. All rights reserved.

  5. Hit or Run: Exploring Aggressive and Avoidant Reactions to Interpersonal Provocation Using a Novel Fight-or-Escape Paradigm (FOE

    Directory of Open Access Journals (Sweden)

    Frederike Beyer

    2017-10-01

    Full Text Available Interpersonal provocation presents an approach-avoidance conflict to the provoked person: responding aggressively might yield the joy of retribution, whereas withdrawal can provide safety. Experimental aggression studies typically measure only retaliation intensity, neglecting whether individuals want to confront the provocateur at all. To overcome this shortcoming of previous measures, we developed and validated the Fight-or-Escape paradigm (FOE. The FOE is a competitive reaction time (RT task in which the winner can choose the volume of a sound blast to be directed at his/her opponent. Participants face two ostensible opponents who consistently select either high or low punishments. At the beginning of each trial, subjects are given the chance to avoid the encounter for a limited number of times. In a first experiment (n = 27, all women, we found that fear potentiation (FP of the startle response was related to lower scores in a composite measure of aggression and avoidance against the provoking opponent. In a second experiment (n = 34, 13 men, we altered the paradigm such that participants faced the opponents in alternating rather than in random order. Participants completed the FOE as well as the Dot-Probe Task (DPT and the Approach-Avoidance Task (AAT. Subjects with higher approach bias scores in the AAT avoided the provoking opponent less frequently. Hence, individuals with high threat reactivity and low approach motivation displayed more avoidant responses to provocation, whereas participants high in approach motivation were more likely to engage in aggressive interactions when provoked. The FOE is thus a promising laboratory measure of avoidance and aggression.

  6. The Maudsley Obsessive-Compulsive Stimuli Set: validation of a standardized paradigm for symptom-specific provocation in obsessive-compulsive disorder.

    NARCIS (Netherlands)

    Mataix-Cols, D.; Lawrence, N.S.; Wooderson, S.; Speckens, A.E.M.; Phillips, M.L.

    2009-01-01

    This article describes and further validates a standardized symptom-provocation procedure that combines symptom-specific audio instructions and pictures to reliably provoke different kinds of symptom-specific anxiety in obsessive-compulsive disorder, corresponding to its four major symptom

  7. Increase in IL-8, IL-10, IL-13, and RANTES mRNA levels (in situ hybridization) in the nasal mucosa after nasal allergen provocation

    NARCIS (Netherlands)

    Kleinjan, A.; Dijkstra, M. D.; Boks, S. S.; Severijnen, L. A.; Mulder, P. G.; Fokkens, W. J.

    1999-01-01

    BACKGROUND: Allergic inflammation is regulated by the local production and release of several cytokines. OBJECTIVES: This study was designed to assess the changes in mRNA cytokine-positive cells after allergen provocation and to compare these cytokines with tissue eosinophilia as a marker of

  8. A Case Report of Stroke in a Woman with Paradoxical Embolism Associated with Ebstein's Anomaly

    Directory of Open Access Journals (Sweden)

    M. Mazdeh

    2014-04-01

    Full Text Available Introduction: Ebstein's anomaly (EA is a rare congenital malformation of the tricuspid valve, often associated with PFO, which is present in 80-90% of patients & predisposes to para-doxical embolization. Case Report: The case described was a 30 year old female, in the post partum phase, (ten days after normal vaginal delivery who was presented to the emergency department with seizure & Rt sided hemiplegia & aphasia. On brain computed tomography scan there was large in-farct of Lt sided hemisphere in fronto temporopartial, and her brain MRI subsequently con-firmed the infarct. Laboratory tests including coagulation study & infectious tests were nor-mal. But electrocardiogram showed AG block grade I. Trans thoracic and Trans esophageal echocardiography revealed Ebstein's anomaly. Dynamic cardiac MRI showed severe tricus-pid regurgitation due to sown ward displacement of tricuspid valve to apical heart associated with patent foramen oral & ASD (Ejection fraction of right chamber was normal and no evi-dence of clot. Conclusion: After ruling out the other diagnoses, paradoxical emboli was considered as the cause leading to the stroke in this case. (Sci J Hamadan Univ Med Sci 2014; 21 (1:72-75

  9. Caesarean section in the absence of need: a pathologising paradox for public health?

    Science.gov (United States)

    Douché, Jeanie; Carryer, Jenny

    2011-06-01

    Caesarean section in the absence of need: a pathologising paradox for public health? This qualitative study explored the discourses constructing women's choice for a caesarean section, in the absence of clinical indication. The research was informed from the theoretical ideas of poststructuralism that presumes people's reality is shaped discursively through the discourses they encounter. A Foucauldian discourse analysis was undertaken of the transcripts of participant's interviews and the texts of both professional and popular media before inductively discerning the prevailing discourses that influence the choice of caesarean in the absence of need. In shaping women's choice in childbirth the discourses of autonomy, convenience and desire alongside fear and risk were identified in the talk and texts of women, childbirth professionals and popular culture. For the purposes of this article we have confined our focus to the findings related to how caesarean is represented in both professional and popular discourse and include feminist discussions around childbirth as an embodied practice. We contend that the discourses of autonomy, desire and risk unite with broader societal discourses to expose a pathologising paradox in which normal bodily performance emerges as abnormal and the abnormal as normal. The trend has implications for both future healthy populations and the equitable distribution of maternity resources. © 2011 Blackwell Publishing Ltd.

  10. Exploring the nap paradox: are mid-day sleep bouts a friend or foe?

    Science.gov (United States)

    Mantua, Janna; Spencer, Rebecca M C

    2017-09-01

    The mid-day nap, sometimes called a siesta, is a ubiquitous occurrence across the lifespan. It is well established that in addition to reducing sleepiness, mid-day naps offer a variety of benefits: memory consolidation, preparation for subsequent learning, executive functioning enhancement, and a boost in emotional stability. These benefits are present even if a sufficient amount of sleep is obtained during the night prior. However, we present a paradox: in spite of these reported benefits of naps, frequent napping has also been associated with numerous negative outcomes (eg, cognitive decline, hypertension, diabetes), particularly in older populations. This association exists even when statistically controlling for relevant health- and sleep-affecting determinants. An emerging hypothesis suggests inflammation is a mediator between mid-day naps and poor health outcomes, yet further research is necessary. Given this, it may be premature to 'prescribe' naps as a health enhancer. Herein, we aggregate findings from several branches of sleep research (eg, developmental neuroscience, cognitive neuroscience, sleep medicine) to critically examine the paradoxical role of naps in cognitive and somatic health. This review uncovers gaps in the literature to guide research opportunities in the field. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. [Disseminated arterial occlusions revealing bilateral venous thrombosis with paradoxical embolisms].

    Science.gov (United States)

    Elsendoorn, A; Desport, E; Vialle, R; Frat, J-P; Bridoux, F; Touchard, G

    2009-06-01

    Paradoxical embolism is a diagnosis of exclusion. Clinical triad associates deep venous thrombosis with or without pulmonary embolism, arterial embolism, and intracardiac communication with right-to-left shunt. The intracardiac communication is generally related to a patent foramen ovale (PFO). We report a 75-year-old patient, who presented with bilateral deep venous thrombosis of the legs, complicated by massive pulmonary embolism and paradoxical embolisms through a PFO. This resulted in cerebral, mesenteric, splenic and bilateral kidney infarctions. A promptly initiated anticoagulant treatment allowed a favourable outcome.

  12. Herbart paradoxal ? La lecture de Cassirer

    OpenAIRE

    Maigné, Carole

    2012-01-01

    Cet article voudrait éclaircir le paradoxe que Ernst Cassirer décèle chez Johann Friedrich Herbart, auquel il consacre un chapitre dense du volume 3 de son histoire de la philosophie : Le Problème de la connaissance. Il nous semble que le paradoxe se dénoue si Herbart est inscrit dans l’histoire même des écrits de Cassirer, depuis Substance et Fonction jusqu’à la Philosophie des formes symboliques : alors que Herbart s’inscrit pleinement dans cette ontologie fonctionnelle que décrit et promeu...

  13. Paradox in CSR Practice: Suggesting Ambidexterity Capability for MNEs

    DEFF Research Database (Denmark)

    Rana, Mohammad Bakhtiar; Jokela, Paivi

    2017-01-01

    standards, leading to lowering legitimacy. To demonstrate it, we illustrate a case called Grameenphone from Bangladesh that has such a paradoxical condition and argue that the lack of organizational ambidexterity capability (i.e. balancing between social and economic goals) causes this paradox and lowering...... process because it would take into account the multiple stakeholders expectations. MNE subsidiary therefore should develop a governance mechanism that is compatible to the complex organizational and ownership structure across the global operations and supporting ROS mechanism. Developing compatible...

  14. Understanding the paradox of patient pain and patient satisfaction.

    Science.gov (United States)

    Quinlan-Colwell, Ann Daly

    2009-09-01

    Pain, in all probability, is the most common symptom experienced by individuals who interact with health care providers. It is understood as a complex and highly individual experience. This complexity is reflected in the paradoxical relationship between patient satisfaction and patient reported pain scores. Using a holistic, caring approach, nurses can optimize the effect of analgesia and facilitate comfort for the person living in pain. Caring for the patient in pain begins with heartfelt compassion and intention to help the person who is suffering. The author describes how the complex relationship and interchange between the patient and the holistic nurse explains the paradox.

  15. Paradoxical intention in the treatment of obsessional flatulence ruminations.

    Science.gov (United States)

    Milan, M A; Kolko, D J

    1982-06-01

    A case study of the paradoxical treatment of long standing obsessional ruminations about flatulence in a 33-year old female respiratory therapist is described. Self-reported estimates of the frequency and intensity of flatulence were unaffected by a misconception correction procedure that entailed the presentation of scientific data disconfirming the bases of her concerns. Paradoxical instructions to intensify flatus emissions were then employed. These instructions resulted in a rapid elimination of the obsessional ruminations; this improvement was enhanced at 1 yr follow-up.

  16. Paradoxical intention in the treatment of chronic anorexia nervosa.

    Science.gov (United States)

    Hsu, L K; Lieberman, S

    1982-05-01

    Eight patients with chronic anorexia nervosa were treated by the authors with a paradoxical approach. At follow-up 2-4 years later four of the patients had maintained a normal weight (within 15% of average weight), and only one patient was at a very low weight. The authors found this encouraging but caution that this technique does not address the individual's personality difficulties, for it did not appear to have improved the patients' social and sexual functioning. They believe, however, that paradoxical intention is worthy of further study in treating chronic anorexia nervosa.

  17. A diagram illustrating the resolution of the twins paradox

    Science.gov (United States)

    Kiang, Tao

    1992-03-01

    The so-called 'twins paradox' in special relativity arises out of a confusion between clock rates and clock readings. However, to resolve the paradox properly, one has to recognize not only that the traveling twin uses two coordinate systems. One must also note that the Lorentz transformation between the coordinate system on the way back and the earth-bound twin's system (x, t) is not of the usual form given in texts but contains constants pertaining to the coordinates at the turnaround. A diagram is given showing how differential aging obtains while the relative clock rates are symmetrical throughout.

  18. Paradoxical intervention in the psychotherapeutic relationship as viewed from an ecosystemic perspective

    OpenAIRE

    2014-01-01

    M.A. (Clinical Psychology) This study traces the description of Paradox as a therapeutic measure by numerous therapists since Erikson first used the paradox in the form of positive reframing during the thirties. Major theoretical definitions of the paradoxical communication are reviewed. The therapeutic Paradoxical intervention is categorized into a series of relatively circumscribed intervention strategies, each of which shares theoretical similarities but emphasizes different aspects of ...

  19. embracing uncertainties: the paradox of environmental education ...

    African Journals Online (AJOL)

    ions to children and that this knowledge is what they need to objectively know ... institution which may not want too many free thinking people emerging ..... Southern Afr. J. Env. Edilc., 18, 1998 83 am in now, there are so many other experiences for me to (re )-discover. So how do I view myself as an environmental educator,.

  20. Paradoxical (REM) sleep deprivation in mice using the small-platforms-over-water method: polysomnographic analyses and melanin-concentrating hormone and hypocretin/orexin neuronal activation before, during and after deprivation.

    Science.gov (United States)

    Arthaud, Sebastien; Varin, Christophe; Gay, Nadine; Libourel, Paul-Antoine; Chauveau, Frederic; Fort, Patrice; Luppi, Pierre-Herve; Peyron, Christelle

    2015-06-01

    Studying paradoxical sleep homeostasis requires the specific and efficient deprivation of paradoxical sleep and the evaluation of the subsequent recovery period. With this aim, the small-platforms-over-water technique has been used extensively in rats, but only rare studies were conducted in mice, with no sleep data reported during deprivation. Mice are used increasingly with the emergence of transgenic mice and technologies such as optogenetics, raising the need for a reliable method to manipulate paradoxical sleep. To fulfil this need, we refined this deprivation method and analysed vigilance states thoroughly during the entire protocol. We also studied activation of hypocretin/orexin and melanin-concentrating hormone neurones using Fos immunohistochemistry to verify whether mechanisms regulating paradoxical sleep in mice are similar to those in rats. We showed that 48 h of deprivation was highly efficient, with a residual amount of paradoxical sleep of only 2.2%. Slow wave sleep and wake quantities were similar to baseline, except during the first 4 h of deprivation, where slow wave sleep was strongly reduced. After deprivation, we observed a 124% increase in paradoxical sleep quantities during the first hour of rebound. In addition, 34% of hypocretin/orexin neurones were activated during deprivation, whereas melanin-concentrated hormone neurones were activated only during paradoxical sleep rebound. Corticosterone level showed a twofold increase after deprivation and returned to baseline level after 4 h of recovery. In summary, a fairly selective deprivation and a significant rebound of paradoxical sleep can be obtained in mice using the small-platforms-over-water method. As in rats, rebound is accompanied by a selective activation of melanin-concentrating hormone neurones. © 2014 European Sleep Research Society.

  1. Paradox of Migration in Kolkata: A Megacity in GBM Delta

    Science.gov (United States)

    Das, S.; Hazra, S.; Ghosh, T.

    2015-12-01

    Contrary to other coastal cities (Mumbai, Chennai, Bhubaneswar etc.) in India, Kolkata, the largest city of India until 1990, has been showing a persistent trend of out-migration over the last decade. The situation is more paradoxical when compared to Dhaka in Bangladesh, the other coastal city in Ganga-Brahmaputra-Meghna (GBM) delta. Exacerbating impacts of Climate Change like accelerated sea level rise, impact of cyclones, rising temperature and high rainfall events and waterlogging, vis-à-vis the density of poor population in slums, Kolkata has been assessed as one of the most vulnerable cities of the world. However, Kolkata has long been a preferred destination for migrants for its port based economy, existence of industrial belt with labour intensive industries. The city and its surrounding districts attracted a massive influx of trans-border migrants when India and Bangladesh gained Independence in 1947 and 1971 respectively. The paper attempts to explore reasons behind the present trend of depopulation in the erstwhile preferred migration destination. This paper distinguishes between 'Kolkata City' (census district) with 4.5 million residents and 'Kolkata Megacity' which encompasses also the peri-urban areas and home to almost 14.1 million people according to Census 2011. Analysing migration as an ongoing research activity under DECCMA project, an overall 'in-migration' pattern can be deciphered in Kolkata 'megacity'. On the contrary, the Kolkata 'city' located right in the heart of the megacity exhibits negative net migration (-5.11%) i.e. high 'out-migration'. Plausible causes can be movement of people from Kolkata 'city' to peri-urban areas and satellite towns (urban to urban migration) probably due to closure of labour intensive industries, comparatively lower land prices, availability of space and accommodation, lower costs of living, development of different modes of commutation and communication. Further growth of population in the Kolkata Megacity

  2. A Psychological Taxonomy of Organizational Innovation: Resolving the Paradoxes

    Science.gov (United States)

    Cropley, David; Cropley, Arthur

    2012-01-01

    The process of innovation involves numerous contradictions not adequately addressed by business-oriented approaches, in particular the problem that what seem to be mutually antagonistic factors are involved. Psychological research on creativity, especially the 4 "Ps" (process, person, product, and press) and the paradoxes of creativity…

  3. Aggression; a Paradoxical pathology of the mind | Kitapondya | Dar ...

    African Journals Online (AJOL)

    Dar Es Salaam Medical Students' Journal. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 15, No 1 (2008) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. Aggression; a Paradoxical pathology of the mind.

  4. Globalization and Religion in Historical Perspective: A Paradoxical Relationship

    Directory of Open Access Journals (Sweden)

    Luke M. Herrington

    2013-03-01

    Full Text Available Religion has long been a driving force in the process of globalization. This idea is not controversial or novel thinking, nor is it meant to be. However, the dominant reasoning on the subject of globalization, expressed by authors like Thomas Friedman, places economics at the center of analysis, skewing focus from the ideational factors at work in this process. By expanding the definition of globalization to accommodate ideational factors and cultural exchange, religion’s agency in the process can be enabled. Interestingly, the story of religion and globalization is in some ways the history of globalization, but it is riddled with paradoxes, including the agent-opponent paradox, the subject of this article. Religion and globalization have a co-constitutive relationship, but religious actors are both agents of globalization and principals in its backlash. While some actors might benefit from a mutually reinforcing relationship with globalization, others are marginalized in some way or another, so it is necessary to expose the links and wedges that allow for such a paradox. To that end, the concepts of globalization and religious actors must be defined, and the history of the agent-opponent paradox, from the Buddhists of the Silk Road to the Jubilee campaign of 2000, must be elucidated.

  5. Working-life - A paradox in Knowledge-Intensive Companies

    DEFF Research Database (Denmark)

    Ipsen, Christine

    2004-01-01

    A Working-Life Paradox in Knowledge Intensive Companies Keywords: Knowledge work, knowledge management, working-life, consulting companies. The purpose of this article is to identify the influence knowledge-work has on working life of the personnel in knowledge-intensive companies, more precisely...

  6. Managing Polarity, Paradox, and Dilemma during Leader Transition

    Science.gov (United States)

    Manderscheid, Steven V.; Freeman, Peter D.

    2012-01-01

    Purpose: The purpose of this study is to review literature relevant to leader transition and the navigation of polarities, paradoxes, and dilemmas that exist in organizations. Furthermore, the researchers aim to critique the literature and provide suggestions for practitioners and researchers interested in leader transition through the lens of…

  7. Apparent paradoxes in classical electrodynamics: relativistic transformation of force

    Energy Technology Data Exchange (ETDEWEB)

    Kholmetskii, A L [Department of Physics, Belarusian State University, 4, F Skorina Avenue, 220080 Minsk (Belarus); Yarman, T [Department of Engineering, Okan University Istanbul, Turkey and Savronik, Eskisehir, Turkey (Turkey)

    2007-05-15

    In this paper, we analyse a number of paradoxical teaching problems of classical electrodynamics, dealing with the relativistic transformation of force for complex macro systems, consisting of a number of subsystems with nonzero relative velocities such as electric circuits that change their shape in the course of time.

  8. Organizing the HRM function: Responses to paradoxes, variety and dynamism

    NARCIS (Netherlands)

    Keegan, Anne; Bitterling, Ilja; Sylva, Hella; Hoeksema, L.H.

    2017-01-01

    We develop empirically based insights from five case studies and argue that how actors respond to paradoxical tensions helps to explain variety and dynamism in how the HRM function is organized. It also helps to clarify why widely popular models with clearly prescribed structures take on a variety

  9. The EPR Paradox: Einstein Scrutinises Quantum Mechanics -28 ...

    Indian Academy of Sciences (India)

    he detailed the Copenhagen interpretation of quantum mechanics. He argued that the EPR paradox does not prove the incompleteness of quantum theory and that the statement "in no way disturbing the system" has to be interpreted differently in quantum mechanics. A measurement on particle P1 changes the very circum-.

  10. The happiness paradox: your friends are happier than you

    NARCIS (Netherlands)

    Bollen, J.; Leemput, van de I.A.; Goncalves Souza, M.B.; Ruan, G.

    2016-01-01

    Most individuals in social networks experience a so-called Friendship Paradox: they are less popular than their friends on average. This effect may explain recent findings that widespread social network media use leads to reduced happiness. However the relation between popularity and happiness is

  11. Humanizing the Humanities: Some Reflections on George Steiner's "Brutal Paradox."

    Science.gov (United States)

    Karier, Clarence J.

    1990-01-01

    Considers how literary critic, George Steiner, explores the failure of Western Civilization to humanize humanity. Analyzes Steiner's ultimately elitist model of culture to shed light on implications of his brutal paradox in which Nazism's death camps are juxtaposed to high culture. Theorizes about the possibilities of a culture inclusive of all…

  12. Unravelling migrants' health paradoxes: a transdisciplinary research agenda.

    Science.gov (United States)

    Roura, Maria

    2017-07-24

    The Social Determinants of Health literature has consistently found that a higher socioeconomic status is associated with better health outcomes even after adjusting for traditional risk factors. However, research findings in the field of Migrants' Health suggest that the socioeconomic/health gradient does not always behave as expected for migrants and their descendants. The mismatch of findings in these two long-standing parallel research traditions is exemplified by frequent reports of paradoxical findings in the scientific literature: the healthy migrant paradox, the ethnic density paradox and the diminishing returns paradox. This paper outlines a transdisciplinary research agenda to elucidate the social processes that underpin these disconcerting findings and calls for a shift from a pathogenic deficit model that sees migrants as a burden to their reconceptualisation as actively engaged citizens in search of solutions. Amidst a severe refugee crisis, fears of terrorist attacks and political capitalisation of these tragedies to foster antimigrant sentiments, this is urgently needed. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  13. Underlying Paradox in the European Union's Multilingualism Policies

    Science.gov (United States)

    Johnson, Fern L.

    2013-01-01

    The European Union (EU) has developed comprehensive policies in recent years to promote multilingualism. In this article, major EU policy statements on multilingualism are analyzed to demonstrate how their underlying language ideology produces paradox by both encouraging multilingualism and regulating its definition within the EU. The first…

  14. Frontloading with Paradox & Double Binds in Adventure Education Facilitation.

    Science.gov (United States)

    Priest, Simon; Gass, Michael

    1994-01-01

    Frontloading is a learning strategy used in adventure education in which participants are briefed on the learning objectives prior to the activity, thereby encouraging learning to take place before or during the event. Describes indirect frontloading techniques (paradox and double binds) that facilitate learning with clients who have…

  15. The Paradox of Malnutrition in Developing Countries | Vonke ...

    African Journals Online (AJOL)

    This paper investigates the paradox of malnutrition- the coexistence of both under and over-nutrition in developing countries, particularly over-nutrition. ... The data reveals the prevalence of hunger or under-nutrition and chronic diseases related to over-nutrition (overweight or obesity) in developing countries. This is ...

  16. Complete resolution of the quantum Zeno paradox for outside observers

    Science.gov (United States)

    Hotta, M.; Morikawa, M.

    2004-05-01

    The quantum Zeno paradox is fully resolved for the purely indirect and incomplete measurements performed by the detectors outside the system. The survival probability of an excited state is not at all changed by the outside measurements, provided the system satisfies a natural condition for outside measurements.

  17. Service Recovery Paradox In Indian Banking Industry: An Empirical Investigation

    Directory of Open Access Journals (Sweden)

    Arunesh Garg

    2013-10-01

    Full Text Available The present study examines existence of service recovery paradox in Indian banking industry. The study is taken up in the tri-city of Chandigarh, Panchkula and Mohali. The respondents are catego- rized into failure and no-failure groups on the basis of their service experience. Failure group consti- tutes those respondents who have experienced service recovery, and has been further divided into five sub-groups ranging from service recovery++ (service recovery better than expected to service recovery- - (service recovery worse than expected. Service recovery paradox is examined by com- paring service recovery++ group with no-failure group. The study shows evidence for existence of service recovery paradox in relation to satisfaction. It has been concluded that for service recovery paradox to exist, recovery effort has to be exceptionally good and much better than expectation level of the customer. The study suggests that service managers should take service failure as an opportunity to appease customers by providing a much better than expected recovery experience. However, organizations should not plan to create service failure situations because if they falter on imparting the recovery, customer satisfaction may be influenced negatively.

  18. Inductive probability and the paradox of ideal evidence

    NARCIS (Netherlands)

    Kuipers, Theo A.F.

    1976-01-01

    In section I the notions of logical and inductive probability will be discussed as well as two explicanda, viz. degree of confirmation, the base for inductive probability, and degree of evidential support, Popper's favourite explicandum. In section II it will be argued that Popper's paradox of ideal

  19. Classical Angular Momentum of Light: A Paradox and its Resolution

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 8; Issue 10. Classical Angular Momentum of Light: A Paradox and its Resolution. K Vijay Kumar N Kumar. Classroom Volume 8 Issue 10 October 2003 pp 69-75. Fulltext. Click here to view fulltext PDF. Permanent link:

  20. Can Rose’s paradox be useful in crime prevention?

    DEFF Research Database (Denmark)

    Christoffersen, Mogens; Joshi, Heather

    2015-01-01

    Geoffrey Rose’s prevention paradox obtains when the majority of cases with an adverse outcome come from a population of low or moderate risk, and only a few from a minority ‘high risk’ group. Preventive treatment is then better targeted widely than on the ‘high risk’ minority. This study tests wh...

  1. A Paradoxical Academic Identity: Fate, Utopia and Critical Hope

    Science.gov (United States)

    Sutton, Paul

    2015-01-01

    Using a dialectical mode of exposition, I offer a reflexive sociological theorisation of the paradox that characterises my academic identity: a fatalistic disenchantment concerning the colonisation of Higher Education (HE) by neoliberalism co-exists with a utopianism concerning HE's emancipatory possibilities. I begin with a discussion of Weber's…

  2. The paradox of pedagogy transposition: Learning from inhibitors to ...

    African Journals Online (AJOL)

    Definition of paradox used in this paper is "a person or thing conflicting with a preconceived notion of what is reasonable or possible" (Allen 1990:862). A belief that a pedagogy developed and proven in one context may generalize or exist comfortably in other contexts, may have a base in a simplistic view of the importance ...

  3. Time symmetry and interpretation of quantum mechanics. [Paradoxes

    Energy Technology Data Exchange (ETDEWEB)

    de Beauregard, O.C.

    1976-10-01

    A drastic resolution of the quantum paradoxes is proposed, combining (I) von Neumann's postulate that collapse of the state vector is due to the act of observation, and (II) my reinterpretation of von Neumann's quantal irreversibility as an equivalence between wave retardation and entropy increase, both being ''factlike'' rather than ''lawlike'' (Mehlberg). This entails a coupling of the two de jure symmetries between (I) retarded and (II) advanced waves, and between Aristotle's information as (I) learning and (II) willing awareness. Symmetric acceptance of cognizance as a source of retarded waves, and of will as a sink of advanced waves, is submitted as a central ''paradox'' of the Copernican or Einsteinian sort, out of which new light is shed upon previously known paradoxes, such as the EPR paradox, Schroedinger's cat, and Wigner's friend. Parapsychology is thus found to creep into the picture.

  4. Climate policy and nonrenewable resources : The green paradox and beyond

    NARCIS (Netherlands)

    Pittel, Karen; van der Ploeg, Rick; Withagen, Cees

    2014-01-01

    Recent developments suggest that well-intended climate policies–including carbon taxes and subsidies for renewable energy – might not accomplish what policy makers intend. Hans-Werner Sinn has described a "green paradox," arguing that these policies could hasten global warming by encouraging owners

  5. A classical model explaining the OPERA velocity paradox

    CERN Document Server

    Broda, Boguslaw

    2011-01-01

    In the context of the paradoxical results of the OPERA Collaboration, we have proposed a classical mechanics model yielding the statistically measured velocity of a beam higher than the velocity of the particles constituting the beam. Ingredients of our model necessary to obtain this curious result are a non-constant fraction function and the method of the maximum-likelihood estimation.

  6. Paradoxes of Nationhood: Despondency and Belief in Tanure ...

    African Journals Online (AJOL)

    Paradoxes of Nationhood: Despondency and Belief in Tanure Ojaide's Delta Blues and "Home Songs". B Bassey ... Delta Blues and Home Songs is Ojaide's reaction to the killing of Ken Saro-Wiwa, a poet and martyred campaigner for a more equitable allocation of national resources. This paper shows how Ojaide ...

  7. Merleau-Ponty on Human Motility and Libet's Paradox | Mooney ...

    African Journals Online (AJOL)

    and-antedating” hypothesis/paradox based on the results of an on-going series of experiments dating back to 1964 that measured the neural adequacy [brain wave activity] of “conscious sensory experience”. What is fascinating about the ...

  8. Boko Haram Terrorism in Nigeria: The Paradox and Challenges of ...

    African Journals Online (AJOL)

    The paradox of Nigeria.s Big Brother foreign policy towards her neighbours, in the past five decades, has entrenched religious fanaticism, criminality especially arms smuggling and borderless irregular migration in the northern parts of the country, exposing the beleaguered country to the whims of terrorists and comatose ...

  9. Merleau-Ponty on Human Motility and Libet's Paradox

    African Journals Online (AJOL)

    denise

    and-antedating” hypothesis/paradox based on the results of an on-going series of experiments dating back to 1964 that measured the neural adequacy [brain wave activity] of “conscious sensory experience”. What is fascinating about the ...

  10. Effects of Paradoxical and Self-Control Directives in Counseling.

    Science.gov (United States)

    Lopez, Frederick G.; Wambach, Cathrine A.

    1982-01-01

    Subjects (N=32) with recurring procrastination problems were assigned to either of two directive interview conditions (paradoxical or self-control) or to a no-interview control condition. Results indicated both directive groups exhibited generally greater improvement over time than controls and that opposing forms of direction promoted different…

  11. Recent Insights into the Paradoxical Effect of Echinocandins

    Directory of Open Access Journals (Sweden)

    Johannes Wagener

    2017-12-01

    Full Text Available Echinocandin antifungals represent one of the most important drug classes for the treatment of invasive fungal infections. The mode of action of the echinocandins relies on inhibition of the β-1,3-glucan synthase, an enzyme essentially required for the synthesis of the major fungal cell wall carbohydrate β-1,3-glucan. Depending on the species, echinocandins may exert fungicidal or fungistatic activity. Apparently independent of this differential activity, a surprising in vitro phenomenon called the “paradoxical effect” can be observed. The paradoxical effect is characterized by the ability of certain fungal isolates to reconstitute growth in the presence of higher echinocandin concentrations, while being fully susceptible at lower concentrations. The nature of the paradoxical effect is not fully understood and has been the focus of multiple studies in the last two decades. Here we concisely review the current literature and propose an updated model for the paradoxical effect, taking into account recent advances in the field.

  12. MCM Paradox: Abundance of Eukaryotic Replicative Helicases and Genomic Integrity

    Directory of Open Access Journals (Sweden)

    Mitali Das

    2014-01-01

    Full Text Available As a crucial component of DNA replication licensing system, minichromosome maintenance (MCM 2–7 complex acts as the eukaryotic DNA replicative helicase. The six related MCM proteins form a heterohexamer and bind with ORC, CDC6, and Cdt1 to form the prereplication complex. Although the MCMs are well known as replicative helicases, their overabundance and distribution patterns on chromatin present a paradox called the “MCM paradox.” Several approaches had been taken to solve the MCM paradox and describe the purpose of excess MCMs distributed beyond the replication origins. Alternative functions of these MCMs rather than a helicase had also been proposed. This review focuses on several models and concepts generated to solve the MCM paradox coinciding with their helicase function and provides insight into the concept that excess MCMs are meant for licensing dormant origins as a backup during replication stress. Finally, we extend our view towards the effect of alteration of MCM level. Though an excess MCM constituent is needed for normal cells to withstand stress, there must be a delineation of the threshold level in normal and malignant cells. This review also outlooks the future prospects to better understand the MCM biology.

  13. Pain provocation following sagittal plane repeated movements in people with chronic low back pain: Associations with pain sensitivity and psychological profiles.

    Science.gov (United States)

    Rabey, Martin; Smith, Anne; Beales, Darren; Slater, Helen; O'Sullivan, Peter

    2017-07-01

    Provocative pain responses following standardised protocols of repeated sagittal plane spinal bending have not been reported in people with chronic low back pain (CLBP). Potential differing pain responses to movement likely reflect complex sensorimotor interactions influenced by physical, psychological and neurophysiological factors. To date, it is unknown whether provocative pain responses following repeated bending are associated with different pain sensitivity and psychological profiles. Therefore the first aim of this study was to determine whether data-driven subgroups with different, clinically-important pain responses following repeated movement exist in a large CLBP cohort, specifically using a standardised protocol of repeated sagittal plane spinal bending. The second aim was to determine if the resultant pain responses following repeated movement were associated with pain and disability, pain sensitivity and psychological factors. Clinically-important (≥2-points, 11-point numeric rating scale) changes in pain intensity following repeated forward/backward bending were examined. Participants with different provocative pain responses to forward and backward bending were profiled on age, sex, pain sensitivity, psychological variables, pain characteristics and disability. Three groups with differing provocative pain responses following repeated movements were derived: (i) no clinically-important increased pain in either direction (n=144, 49.0%), (ii) increased pain with repeated bending in one direction only (unidirectional, n=112, 38.1%), (iii) increased pain with repeated bending in both directions (bidirectional, n=38, 12.9%). After adjusting for psychological profile, age and sex, for the group with bidirectional pain provocation responses following repeated spinal bending, higher pressure and thermal pain sensitivity were demonstrated, while for the group with no increase in pain, better cognitive and affective psychological questionnaire scores were

  14. Dual dynamics of promises, and waiting games around emerging nanotechnologies.

    NARCIS (Netherlands)

    Parandian, A.; Rip, Arie; te Kulve, Haico

    2012-01-01

    Newly emerging science and technologies (NEST) are shaped by dynamics of promises. There is a paradoxical effect: diffuse and open-ended promises are forceful in policy discourse, but may hinder the realisation of these promises. Innovation actors are reluctant to invest in concrete developments

  15. Provocation gratuite ? Commodification des logiques d’opposition et de différenciation du cinéma indépendant américain contemporain

    OpenAIRE

    Sauvage, Célia

    2015-01-01

    Cet essai se propose d’analyser le concept de provocation, selon un cas d’étude précis, celui du cinéma indépendant américain, comme stratégie de différenciation et outil de positionnement compétitif face à une industrie dominante hollywoodienne. La provocation se formalise tour à tour sous une forme discursive, promotionnelle et esthétique. Les auteurs cultivent une idéologie rebelle et un discours de la contreculture. Le marketing, lui, met en avant le caractère provocant, dérangeant des fi...

  16. Diabetic Emergencies

    Science.gov (United States)

    ... Emergencies A-Z Share this! Home » Emergency 101 Diabetic Emergencies It is estimated that more than 20 ... they have it. The best way to prevent diabetic emergencies is to effectively manage the disease through ...

  17. ASA's Chandra Neon Discovery Solves Solar Paradox

    Science.gov (United States)

    2005-07-01

    NASA's Chandra X-ray Observatory survey of nearby sun-like stars suggests there is nearly three times more neon in the sun and local universe than previously believed. If true, this would solve a critical problem with understanding how the sun works. "We use the sun to test how well we understand stars and, to some extent, the rest of the universe," said Jeremy Drake of the Harvard-Smithsonian Center for Astrophysics in Cambridge, Mass. "But in order to understand the sun, we need to know exactly what it is made of," he added. It is not well known how much neon the sun contains. This is critical information for creating theoretical models of the sun. Neon atoms, along with carbon, oxygen and nitrogen, play an important role in how quickly energy flows from nuclear reactions in the sun's core to its edge, where it then radiates into space. Chandra X-ray Spectrum of II Pegasi Chandra X-ray Spectrum of II Pegasi The rate of this energy flow determines the location and size of a crucial stellar region called the convection zone. The zone extends from near the sun's surface inward approximately 125,000 miles. The zone is where the gas undergoes a rolling, convective motion much like the unstable air in a thunderstorm. "This turbulent gas has an extremely important job, because nearly all of the energy emitted at the surface of the sun is transported there by convection," Drake said. The accepted amount of neon in the sun has led to a paradox. The predicted location and size of the solar convection zone disagree with those deduced from solar oscillations. Solar oscillations is a technique astronomers previously relied on to probe the sun's interior. Several scientists have noted the problem could be fixed if the abundance of neon is in fact about three times larger than currently accepted. Attempts to measure the precise amount of neon in the Sun have been frustrated by a quirk of nature; neon atoms in the Sun give off no signatures in visible light. However, in a gas

  18. Transgression médiatique et provocations décadentes: La décadence comme comportement médiatique.

    Directory of Open Access Journals (Sweden)

    Yoan Vérilhac

    2012-03-01

    Full Text Available The decadent and symbolist movements are deeply connected to the creation of media: newspapers, small reviews which make the promotion of the young poets and their original works. In the 1880’s, the decadent reviews use in a provocative way the codes and the media potentialities. However this provocative press is based on a double language (especially about the relationship with the public, and this contradiction generates a negative image in the popular press: the new generation of poets and writers appears to be a noisy group of « hoaxers ». Therefore, around 1890, when the new reviews grouped around the « symbolist » label define themselves a media identity, it is important for them to distance from decadent behaviours. The decadent moment of the mediatization of literature is thus indispensable to understand the history of connections between press and poetic avant-gardes.

  19. Modulation of neurotrophin and neurotrophin receptor expression in nasal mucosa after nasal allergen provocation in allergic rhinitis.

    Science.gov (United States)

    Raap, U; Fokkens, W; Bruder, M; Hoogsteden, H; Kapp, A; Braunstahl, G-J

    2008-04-01

    Patients with allergic rhinitis (AR) feature both allergic airway inflammation and a hyperresponsiveness to nonspecific stimuli which is partly neuronally controlled. Still, it is unclear whether or not neurotrophins are involved in airway pathophysiology of AR and in nasobronchial interaction. Nine AR patients with mono-allergy to grass pollen and nine healthy controls underwent nasal allergen provocation (NP). Serum samples, nasal and bronchial biopsies were taken before (T(0)) and 24 h after (T(24)) NP. Pan-neurotrophin receptor p75(NTR), tyrosine kinase A (trkA), trkB, nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF) were assessed with immunohistochemistry, and NGF and BDNF levels with ELISA. At T(24), BDNF and NGF were upregulated in nasal mucosa (P neurotrophins and receptors in bronchial mucosa. This study shows that neurotrophins and their receptors are expressed in human airways. Allergic rhinitis was characterized by a modulation of BDNF, NGF, and trkB in nasal mucosa after NP and a correlation of nasal BDNF with the maximal increase of total nasal symptom score. Therefore, our data suggest that neurotrophins participate in upper-airway pathophysiology in AR, whereas their role in nasobronchial interaction remains unclear.

  20. A pilot study on the validity of using pictures and videos for individualized symptom provocation in obsessive-compulsive disorder.

    Science.gov (United States)

    Simon, Daniela; Kischkel, Eva; Spielberg, Rüdiger; Kathmann, Norbert

    2012-06-30

    Distressing symptom-related anxiety is difficult to study in obsessive-compulsive disorder (OCD) due to the disorder's heterogeneity. Our aim was to develop and validate a set of pictures and films comprising a variety of prominent OCD triggers that can be used for individually tailored symptom provocation in experimental studies. In a two-staged production procedure a large pool of OCD triggers and neutral contents was produced and preselected by three psychotherapists specialized in OCD. A sample of 13 OCD patients and 13 controls rated their anxiety, aversiveness and arousal during exposure to OCD-relevant, aversive and neutral control stimuli. Our findings demonstrate differences between the responses of patients and controls to OCD triggers only. Symptom-related anxiety was stronger in response to dynamic compared with static OCD-relevant stimuli. Due to the small number of 13 patients included in the study, only tentative conclusions can be drawn and this study merely provides a first step of validation. These standardized sets constitute valuable tools that can be used in experimental studies on the brain correlates of OCD symptoms and for the study of therapeutic interventions in order to contribute to future developments in the field. Copyright © 2012 Elsevier Ltd. All rights reserved.

  1. Design and dosimetric analysis of a 385 MHz TETRA head exposure system for use in human provocation studies.

    Science.gov (United States)

    Schmid, Gernot; Bolz, Thomas; Uberbacher, Richard; Escorihuela-Navarro, Ana; Bahr, Achim; Dorn, Hans; Sauter, Cornelia; Eggert, Torsten; Danker-Hopfe, Heidi

    2012-10-01

    A new head exposure system for double-blind provocation studies investigating possible effects of terrestrial trunked radio (TETRA)-like exposure (385 MHz) on central nervous processes was developed and dosimetrically analyzed. The exposure system allows localized exposure in the temporal brain, similar to the case of operating a TETRA handset at the ear. The system and antenna concept enables exposure during wake and sleep states while an electroencephalogram (EEG) is recorded. The dosimetric assessment and uncertainty analysis yield high efficiency of 14 W/kg per Watt of accepted antenna input power due to an optimized antenna directly worn on the subject's head. Beside sham exposure, high and low exposure at 6 and 1.5 W/kg (in terms of maxSAR10g in the head) were implemented. Double-blind control and monitoring of exposure is enabled by easy-to-use control software. Exposure uncertainty was rigorously evaluated using finite-difference time-domain (FDTD)-based computations, taking into account anatomical differences of the head, the physiological range of the dielectric tissue properties including effects of sweating on the antenna, possible influences of the EEG electrodes and cables, variations in antenna input reflection coefficients, and effects on the specific absorption rate (SAR) distribution due to unavoidable small variations in the antenna position. This analysis yielded a reasonable uncertainty of analysis. Copyright © 2012 Wiley Periodicals, Inc.

  2. Comparison of levocabastine, a new selective H1-receptor antagonist, and disodium cromoglycate, in a nasal provocation test with allergen.

    Science.gov (United States)

    Kolly, M; Pécoud, A

    1986-10-01

    The effect of intranasal administration of levocabastine, a new selective H1-receptor antagonist, was investigated in a nasal provocation test (NPT) performed with allergens. The NPT allowed a quantitative estimation of the nasal allergic threshold (concentration of allergen necessary to trigger the reaction). In addition, the intensity of the three major rhinitis symptoms (obstruction, rhinorrhea and sneezing) was determined. Twelve adult patients, allergic to grass pollen, underwent a first NPT without pretreatment ('initial NPT'); the NPT was then repeated after the single intranasal administration of either placebo, 8 mg disodium cromoglycate (DSCG) or 0.2 mg levocabastine in a double-blind random order. The NPTs gave reproducible results since both the threshold and symptom intensities were similar in the initial NPT and in the NPT performed after placebo. The reaction threshold increased in 8/12 patients after DSCG (0.05 less than P less than 0.1) and in 9/12 patients after levocabastine (P less than 0.05). Levocabastine clearly inhibited rhinorrhea (P less than 0.001) and sneezing (P less than 0.02) but did not influence the nasal obstruction. DSCG inhibited rhinorrhea only (P less than 0.01). The intranasal administration of levocabastine might be useful in the treatment of allergic rhinitis.

  3. John Watson's paradoxical struggle to explain Freud.

    Science.gov (United States)

    Rilling, M

    2000-03-01

    John Watson was fascinated by the discoveries of psychoanalysis, but he rejected Freud's central concept of the unconscious as incompatible with behaviorism. After failing to explain psychoanalysis in terms of William James's concept of habit, Watson borrowed concepts from classical conditioning to explain Freud's discoveries. Watson's famous experiment with Little Albert is interpreted not only in the context of Pavlovian conditioning but also as a psychoanalytically inspired attempt to capture simplified analogues of adult phobic behavior, including the "transference" of emotion in an infant. Watson used his behavioristic concept of conditioned emotional responses to compete with Freud's concepts of displacement and the unconscious transference of emotion. Behind a mask of anti-Freudian bias, Watson surprisingly emerges as a psychologist who popularized Freud and pioneered the scientific appraisal of his ideas in the laboratory.

  4. [The provocation test in children with cow-milk protein and gluten intolerance: evaluation of the clinical response and lesions in the mucous membrane of the small intestine].

    Science.gov (United States)

    Kaczmarski, M

    Provocation test (re-introduction of the noxious protein) was carried out in two groups of patients: (a) with intolerance to the cow-milk proteins (41 children) treated with milk-free diet for 6-24 months, and (b) with gluten intolerance (26 children) treated with gluten-free diet for 6-36 months. The following parameters were compared: type and frequency of the clinical symptoms seen in these patients prior to the introduction of allergen-free diet. Moreover, the type of observed morphological changes in the small intestine mucosa following provocation test were analysed in the groups of 7 patients. A two-year elimination of milk from the diet produces milk tolerance in about 61% patients; clinical symptoms in the remaining children are diversified. Re-introduction of gluten with the diet (provocation test) produces recurrence of gluten intolerance in 96% of children treated with gluten-free diet for 2-3 years. Recurrence of the disease was accompanied by the atrophy of the intestinal villi.

  5. Pressure and tendon strain in the sixth extensor compartment of the wrist during simulated provocative maneuvers for diagnosing extensor carpi ulnaris tendinitis.

    Science.gov (United States)

    Kataoka, Toshiyuki; Moritomo, Hisao; Omori, Shinsuke; Iida, Akio; Omokawa, Shohei; Suzuki, Daisuke; Fujimiya, Mineko; Wada, Takuro; Aoki, Mitsuhiro; Yoshikawa, Hideki

    2015-11-01

    Various provocative maneuvers for diagnosing extensor carpi ulnaris (ECU) tendinitis have been reported; however, it remains unclear which maneuver is the most sensitive to detect ECU tendinitis. To clarify this, we investigated and compared the extratendinous pressure and ECU tendon strain in the sixth extensor compartment of the wrist during various provocative maneuvers for diagnosing ECU tendinitis. Nine upper extremities from nine fresh-frozen cadavers were examined. We investigated extratendinous pressure in the ECU fibro-osseous tunnel of the distal ulna and ECU tendon strain during eight forearm positions-neutral rotation, pronation, supination, pronation with wrist flexion, supination with wrist flexion, supination with wrist extension, both hand and forearm supination, and supination with ECU full loading-to simulate provocative maneuvers reported to detect ECU tendinitis. Pressure was significantly higher during both hand and forearm supination (carpal supination test) and during supination with wrist extension (prayer's hand supination test) than during neutral rotation. The pressure during the carpal supination test was 3 times higher than that during the prayer's hand supination test and 27 times higher than that during the neutral position. Strain was significantly higher during the carpal supination test and during supination with ECU full loading (the ECU synergy test) than during other maneuvers. Both pressure and tendon strain increased most notably during the carpal supination test compared to the other maneuvers, which suggests that the carpal supination test is the most sensitive for the detection of ECU tendinitis.

  6. Unruly energies: Provocations of renewable energy development in a northern German village

    Science.gov (United States)

    Carlson, Jennifer D.

    This dissertation asks how inhabitants of a sustainable village are living out Germany's transition from nuclear to renewable energy. The sustainable village remains a locus of optimistic attachments for renewable energy advocates, who argue that a decentralized power grid will enable people to more directly participate in power production and politics as "energy citizens." Yet while rural areas have become sites of speculation, innovation and growth, few rural-dwellers are enfranchised in (or profiting from) the technoscientific projects in their midst. I draw upon 13 months of fieldwork in a northern German village transformed by wind turbines, photovoltaics and biofuels to consider why, asking what kinds of public life flourish in the absence of democratic engagement with renewable technologies. This ethnography engages the village as multiply constituted across domains of everyday life, including transit, farming, waste management, domestic life, and social gatherings. I found that environmental policy, everyday practices, and the area's material histories combined to produce ontologies---senses of what exists---that circumscribe citizen participation in the energy sector, affording more formal opportunities to men than to women, and privileging farmers' interests in plans that impacted the larger community. These findings illuminate how many villagers become ambivalent toward the project of the energy transition and disenfranchised from its implementation. Yet many who were excluded from formal participation also engaged with renewable technologies as they sensed out their worlds, using tropes of sustainable energy and technoscientific materials to place themselves in this emerging energy polity. Their everyday worldmaking brimmed with what I call unruly energies, structures of feeling that registered more as affects than as discourse. In the village, these took form as sensory disturbances, disquiet among neighbors, technoscientific optimism and skepticism

  7. Can an Evolutionary Analysis Dissolve the Paradox of Horror?

    DEFF Research Database (Denmark)

    Kjeldgaard-Christiansen, Jens; Clasen, Mathias; Johnson, John

    The paradox of horror” is the problem of why so many people are motivated to experience the negative emotions induced by horror media. In this talk, we argue that an evolutionary analysis may dissolve the paradox of horror. From an evolutionary perspective, horror may be analyzed as a simulation...... technology that allows users to attain adaptive experience with perceived threat and negative emotion in a safe environment. The argument is supported by results from a comprehensive MTurk survey of American users of horror media (n=1,071). Results include findings on the personal details (e.g., sex......), supernatural beliefs (e.g., paranormal beliefs), personality traits (e.g., Big Five), horror genre preferences (e.g., supernatural versus natural horror), and horror-induced emotional responses of users of horror media. The strongest individual predictors of horror media enjoyment are sex (male preference...

  8. Crystallization Age of NWA 1460 Shergottite: Paradox Revisited

    Science.gov (United States)

    Nyquist, L. E.; Shih, C-Y.; Reese, Y. D.; Irving, A. J.

    2004-01-01

    We have determined the Rb-Sr age of basaltic shergottite NWA 1460 to be 312 +/- 3 Ma, and the Sm-Nd age to be 352 +/- 30 Ma. The initial Sr and Nd isotopic compositions of NWA 1460 suggest it is an earlier melting product of a Martian mantle source region similar to those of the Iherzolitic shergottites and basaltic shergottite EETA79001, lithology B. The new ages of NWA 1460 and other recently analyzed Martian meteorites leads us to reexamine the paradox that most of the Martian meteorites appear to be younger from the majority of the Martian surface. This paradox continues to pose a challenge to determining a reliable Martian chronology.

  9. A general realistic treatment of the disk paradox

    CERN Document Server

    Pantazis, George

    2016-01-01

    Mechanical angular momentum is not conserved in systems involving electromagnetic fields with non-zero electromagnetic field angular momentum. Conservation is restored only if the total (mechanical and field) angular momentum is considered. Previous studies have investigated this effect, known as "Feynman's Electromagnetic Paradox" or simply "Disk Paradox" in the context of idealized systems (infinite or infinitesimal solenoids and charged cylinders \\etc). In the present analysis we generalize previous studies by considering more realistic systems with finite components and demonstrating explicitly the conservation of the total angular momentum. This is achieved by expressing both the mechanical and the field angular momentum in terms of charges and magnetic field fluxes through various system components. Using this general expression we demonstrate explicitly the conservation of total angular momentum in both idealized and realistic systems (finite solenoid concentric with two charged long cylinders) taking ...

  10. Children's nursing education: 'the future characterised by paradoxes'.

    Science.gov (United States)

    Corkin, Doris; Clarke, Sonya

    2007-10-01

    According to Healthcare Futures 2010 (Warner et al 1998) the future for the nursing and midwifery professions will be characterised by a series of paradoxes. There will be 'a growing emphasis on prevention, yet a great demand for cure and palliation; public reliance upon professionalism within the workforce, yet greater lay assertiveness; a greater demand for technical competence and scientific rationality among nurses and midwives, yet a continuing need for traditional nursing qualities and the time to express them' (Warner et al 1998). If these projections hold true there are significant implications for nursing and midwifery education. This article provides a summary of the development of nurse education and uses the three paradoxes identified to reflect on the past and the present and explore the future of children's nursing education.

  11. Testing the Transivity Explanation of the Allais Paradox

    DEFF Research Database (Denmark)

    Groes, Ebbe; Jacobsen, Hans Jørgen; Sloth, Birgitte

    1999-01-01

    This paper uses a two-dimensional version of a standard common consequence experiment to test the intransitivity explanation of Allais-paradox-type violations of expected utility theory. We compare the common consequence effect of two choice problems differing only with respect to whether...... intransitivity as an explanation of the Allais Paradox. The question whether violations of expected utility are mainly due to intransitivity or to violation of independence is important since it is exactly on this issue the main new decision theories differ...... alternatives are statistically correlated or independent. We framed the experiment so that intransitive preferences could explain violating behavior when alternatives are independent, but not when they are correlated. We found the same pattern of violation in the two cases. This is evidence against...

  12. Perception gustative des lipides alimentaires : paradigme et paradoxes

    Directory of Open Access Journals (Sweden)

    Gaillard Dany

    2008-01-01

    Full Text Available Origin of spontaneous fat preference in mammals remains elusive. It is clearly a multimodal system resulting from the integration of orosensory and post-ingestive signals. For a long time, dietary lipids were thought to be only sensed in the oral cavity through their textural and olfactory cues. Recent data strongly suggest that the sense of taste also plays a significant role in the preference for lipid-rich foods and in lipid-mediated induction of cephalic phase of the digestion in rodents and in humans. Molecular and physiological mechanisms of this new paradigm become known. Some of these data were not fully expected and might be considered, as first sight, as paradoxical. The « fatty taste » paradigm and paradoxes are analyzed in this minireview.

  13. The Faint Young Sun and Faint Young Stars Paradox

    Science.gov (United States)

    Martens, Petrus C.

    2017-10-01

    The purpose of this paper is to explore a resolution for the Faint Young Sun Paradox that has been mostly rejected by the community, namely the possibility of a somewhat more massive young Sun with a large mass loss rate sustained for two to three billion years. This would make the young Sun bright enough to keep both the terrestrial and Martian oceans from freezing, and thus resolve the paradox. It is found that a large and sustained mass loss is consistent with the well observed spin-down rate of Sun-like stars, and indeed may be required for it. It is concluded that a more massive young Sun must be considered a plausible hypothesis.

  14. Privacy Awareness: A Means to Solve the Privacy Paradox?

    Science.gov (United States)

    Pötzsch, Stefanie

    People are limited in their resources, i.e. they have limited memory capabilities, cannot pay attention to too many things at the same time, and forget much information after a while; computers do not suffer from these limitations. Thus, revealing personal data in electronic communication environments and being completely unaware of the impact of privacy might cause a lot of privacy issues later. Even if people are privacy aware in general, the so-called privacy paradox shows that they do not behave according to their stated attitudes. This paper discusses explanations for the existing dichotomy between the intentions of people towards disclosure of personal data and their behaviour. We present requirements on tools for privacy-awareness support in order to counteract the privacy paradox.

  15. Coping styles, paradox, and the cold pressor task.

    Science.gov (United States)

    Efran, J S; Chorney, R L; Ascher, L M; Lukens, M D

    1989-02-01

    The study investigated how coping style differences affected performance on the cold pressor task. Reactions of "monitors" (individuals who prefer having information about stressors) and "blunters" (individuals who avoid cues connected with stressors) were compared, using different instructional sets. The study also assessed the effectiveness of paradoxical intention compared to more traditional cognitive strategies. Monitors and blunters were identified using Miller's recently developed Behavioral Style Scale. All instructional sets improved performance in comparison to a control condition, and individuals generally did better when an instructional set supported their preferred coping style. Paradoxical intention did not show any decided advantage over other strategies. The desirability of designing stress management programs to fit individual coping style patterns is discussed.

  16. Einstein-Podolsky-Rosen Paradox in Twin Images

    Science.gov (United States)

    Moreau, Paul-Antoine; Devaux, Fabrice; Lantz, Eric

    2014-10-01

    Spatially entangled twin photons provide both promising resources for modern quantum information protocols, because of the high dimensionality of transverse entanglement, and a test of the Einstein-Podolsky-Rosen paradox in its original form of position versus impulsion. Usually, photons in temporal coincidence are selected and their positions recorded, resulting in a priori assumptions on their spatiotemporal behavior. In this Letter, we record, on two separate electron-multiplying charge coupled devices cameras, twin images of the entire flux of spontaneous down-conversion. This ensures a strict equivalence between the subsystems corresponding to the detection of either position (image or near-field plane) or momentum (Fourier or far-field plane). We report the highest degree of paradox ever reported and show that this degree corresponds to the number of independent degrees of freedom, or resolution cells, of the images.

  17. Twins Paradox and the Size of Minkowski Universe

    Science.gov (United States)

    Klippert, R.

    2002-12-01

    Since the advent of General Relativity the subject of the spacetime topology has deserved a lot of study, with no definite answer until now available about whether or not the space we live in presents a non flat global 'shape'. For a four-dimensional spacetime and excluding non-standard topology in time, this essentially means that one would like to know whether there exists or not non limited finite spatial dimensions. Remarkably, the formal requirement of absence of internal paradoxes together with the experimentally verified Lorentz transformations may provide a way to rule out multiply-connected spatial topologies. The gedanken Experiment here presented follows closely the example of the twins paradox, with appeal to no more than Special Relativity1 concepts...

  18. The twin paradox and the principle of relativity

    CERN Document Server

    Gron, Oyvind

    2010-01-01

    In the standard formulation of the twin paradox an accelerated twin considers himself as at rest and his brother as moving. Hence, when formulating the twin paradox, one uses the general principle of relativity, i.e. that accelerated and rotational motion is relative. The significance of perfect inertial dragging for the validity of the principle of relativity is made clear. Three new results are reviewed in the discussion. A cosmic time effect which cannot be reduced to the gravitational or the kinematical time dilation. Perfect dragging in an exact solution of Einsteins field equations describing flat spacetime inside a shell with Kerr spacetime outside it. An extended model of Minkowski spacetime in order to avoid introducing absolute acceleration and rotation through the asymptotic emptiness of the Kerr spacetime.

  19. Relativity solution for ``Twin paradox'': a comprehensive solution

    Science.gov (United States)

    Sfarti, A.

    2012-10-01

    We have provided a complete and realistic solution to the problem of Twin Paradox, for the first time, in the frame work of general relativity. Some of the inspiration for this paper has come from the well known papers by Linet and Teyssandier (Phys Rev D 66:024045, 2002) discussing objects moving on geodesics for more general metrics than Schwarzschild. The subject of the "Twin paradox" is encountered frequently in relativity classes but a complete solution in the general relativity framework is not being taught. Our approaches have covered all the cases, starting with inertial motion in flat space time, going through hyperbolic motion in flat space time and ending with the treatment for curved space time.

  20. A computational approach to the twin paradox in curved spacetime

    CERN Document Server

    Fung, Kenneth K H; Lewis, Geraint F; Wu, Xiaofeng

    2016-01-01

    Despite being a major component in the teaching of special relativity, the twin `paradox' is generally not examined in courses on general relativity. Due to the complexity of analytical solutions to the problem, the paradox is often neglected entirely, and students are left with an incomplete understanding of the relativistic behaviour of time. This article outlines a project, undertaken by undergraduate physics students at the University of Sydney, in which a novel computational method was derived in order to predict the time experienced by a twin following a number of paths between two given spacetime coordinates. By utilising this method, it is possible to make clear to students that following a geodesic in curved spacetime does not always result in the greatest experienced proper time.

  1. A resolution to the blue whiting (Micromesistius poutassou) population paradox?

    DEFF Research Database (Denmark)

    Pointin, Fabien; Payne, Mark R.

    2014-01-01

    understood. On one hand, genetic, morphometric, otolith and drift modelling studies point towards the existence of two populations, but, on the other hand, observations of adult distributions point towards a single population. A paradox therefore arises in attempting to reconcile these two sets......We provide the strongest evidence to date supporting the existence of two independent blue whiting (Micromesistius poutassou (Risso, 1827)) populations in the North Atlantic. In spite of extensive data collected in conjunction with the fishery, the population structure of blue whiting is poorly...... further show a difference in the timing of spawning between these sites of at least a month, and meaningful differences in interannual variability. The results therefore support the two-population hypothesis. Furthermore, we resolve the paradox by showing that the acoustic observations cited in support...

  2. Solving the emotion paradox: categorization and the experience of emotion.

    Science.gov (United States)

    Barrett, Lisa Feldman

    2006-01-01

    In this article, I introduce an emotion paradox: People believe that they know an emotion when they see it, and as a consequence assume that emotions are discrete events that can be recognized with some degree of accuracy, but scientists have yet to produce a set of clear and consistent criteria for indicating when an emotion is present and when it is not. I propose one solution to this paradox: People experience an emotion when they conceptualize an instance of affective feeling. In this view, the experience of emotion is an act of categorization, guided by embodied knowledge about emotion. The result is a model of emotion experience that has much in common with the social psychological literature on person perception and with literature on embodied conceptual knowledge as it has recently been applied to social psychology.

  3. THE ANALYSIS OF PARADOXICAL ENGLISH STATEMENTS BY USING SCHEMES

    Directory of Open Access Journals (Sweden)

    Belyaeva, E.A.

    2017-06-01

    Full Text Available The article is aimed at studying the opportunities of implementing visual aids in teaching analytical reading methods to students at language colleges. In the first part the author analyses the category of reading technique, the tasks of teaching basic and analytical reading which are related to the object of the research. The necessity to enhance motivation and cross-cultural competence of learners due to the use of visual aids and authentic texts is being justified. The author argues the applicability of paradoxical statements for demonstration of the conceptual analysis cases. The technique of paradoxical statements’ analysis, allowing to define the key text concepts and the character of their interrelation by making up structural schemes, is being considered. In conclusion of the article examples of the analysis with interpretation and practical recommendations are provided.

  4. Managerial challenges within networks: emphasizing the paradox of network participation

    DEFF Research Database (Denmark)

    Jakobsen, Morten

    Flexibility and access to numerous resources are essential benefits associated with network participation. An important aspect of managing the network participation of a company is to maintain a dynamic portfolio of partners, and thereby keep up the strategic opportunities for development. However......, maintaining the dynamics within a network seems to be a complex challenge. There is a risk that the network ends up in The Paradox of Network Participation. The desired renewal and flexibility are not utilised because the involved parties preserve the existing networks structure consisting of the same...... companies, and hence, the paradox reduces the potential advantages of the network. The objective of this paper is to analyse the fundamental conditions for a company which depends on an efficient network, and based on this discuss how active use of information can reduce the relative importance of trust...

  5. Managerial Challenges Within Networks - Emphasizing the Paradox of Network Participation

    DEFF Research Database (Denmark)

    Jakobsen, Morten

    2003-01-01

    Flexibility and access to numerous resources are essential benefits associated with network participation. An important aspect of managing the network participation of a company is to maintain a dynamic portfolio of partners, and thereby keep up the strategic opportunities for development. However......, maintaining the dynamics within a network seems to be a complex challenge. There is a risk that the network ends up in The Paradox of Network Participation. The desired renewal and flexibility are not utilised because the involved parties preserve the existing networks structure consisting of the same...... companies, and hence, the paradox reduces the potential advantages of the network. The objective of this paper is to analyse the fundamental conditions for a company which depends on an efficient network, and based on this discuss how active use of information can reduce the relative importance of trust...

  6. Safety in the globalising knowledge economy: an analysis by paradoxes.

    Science.gov (United States)

    Ravetz, J R

    2001-09-14

    There is a widespread recognition of a 'crisis' in official scientific expertise, related to the increase of 'uncertainty' and the loss of 'trust', and whose cure is believed to lie in 'participation'. I argue that the crisis results from structural features of the globalising knowledge economy, and the contradictory roles of governments, acting both as promoters of global business enterprise and also as regulators on behalf of a sophisticated and suspicious public. I explain the crisis by substituting 'safety' for 'risk' as the operative concept, and also using 'paradox' as an explanatory tool. I produce a closed-cycle paradox, analogous to the classic Catch-22, to exhibit the contradictions in the situation. I discuss ways of resolving these, which include the recognition of policy-critical ignorance and the adoption of the perspective of post-normal science.

  7. [Paradoxical aggressive reactions to benzodiazepine use: a review].

    Science.gov (United States)

    Saïas, T; Gallarda, T

    2008-09-01

    With growing prescription and availability, benzodiazepine usage in France is on the increase among the general population. Although its anxiolytic action has long been proven, many side effects can be observed. TYPOLOGY AND PREVALENCE: Paradoxical reactions of aggressiveness under benzodiazepines have been discussed in the scientific literature since the 1960s. This term was introduced to describe reactions of agitation and disinhibition occurring during anxiolytic or hypnotic treatment. Physical aggression, rape, impulsive decision-making and violence have been reported, as well as autoaggressiveness and suicide. General population studies indicate a prevalence of these reactions of less than 1%, and meta-analysis has shown that use of benzodiazepines generates aggressiveness more frequently than it reduces it. It has also been shown that long-term memory (anterograde amnesia) can be impaired following the ingestion of a benzodiazepine. Benzodiazepine-linked disinhibition, auto and heteroaggressiveness, anxiety and criminal acts have been associated with various vulnerability factors. Although the risk of these paradoxical reactions depends on the number of such factors present in a single patient, the effects of the type and dose of benzodiazepine on the frequency and the intensity of paradoxical symptoms are not clear. In terms of personality, several studies have demonstrated the role of low-stress control (specifically high-trait anxiety) on aggressiveness under benzodiazepines. Other authors underline the role of borderline personality disorder as a major risk factor predicting paradoxical reactions. Results of a study on borderline patients show a prevalence of benzodiazepine-linked disinhibition of 58%. On a neuropharmacological level, the influence of the GABA system on the serotonin control and the impact of alcohol seem to be established. Benzodiazepines, specifically when associated with alcohol, seem to facilitate GABAergic transmission, which can be

  8. Association and exclusion: the paradox of liberal constitutionalism

    OpenAIRE

    H.N. Hirsch

    2011-01-01

    This paper argues that a central paradox of liberal constitutionalism can be found by closely examining the freedom of association.  Freedom of association includes the right not to associate; thus a regime of individual rights facilitates the creation of marginalized individuals and groups.  These groups then seek social recognition, which liberal constitutionalism cannot easily grant, unless the state itself becomes complicit in discriminatory action.  The existence and protection ...

  9. Interim-Management: A paradox for leadership research?

    OpenAIRE

    Bruns, Jürgen; Kabst, Rüdiger

    2005-01-01

    The study focuses on Interim-Management as a so far rarely discussed phenomenon of the flexible firm. Contradicting popular leadership perception, the authors argue that Interim-Management does not constitute a leadership paradox but can be explained by established organization theory. In particular, transaction cost economics as well as resource-based view help explain the utilization of Interim-Management. Furthermore, the authors show that Interim-Management constitutes a response to reduc...

  10. A General Equilibrium Expression of the Paradox of Thrift

    OpenAIRE

    Christophe Chamley

    1984-01-01

    A model is presented which is derived from some observations of Keynes on the nature of capital. The allocation of investment is analyzed in two economies with random demand shocks which are identical except for the types of markets. In the first, the combination of an asset and forward markets realizes the complete set of markets. In the second, the forward markets are replaced by spot markets. Consumers and entrepreneurs are rational and markets clear. A clear definition of the paradox of t...

  11. Dilemmas and paradoxes of capacity building in African higher education

    DEFF Research Database (Denmark)

    Madsen, Lene Møller; Jensen, Stig; Adriansen, Hanne Kirstine

    2015-01-01

    This chapter discusses and reflects on the dilemmas and paradoxes of capacity building in African higher education by drawing on the findings of the case-based chapters in the book. The collection confirms the importance of using geography of knowledge as an approach for understanding how capacity...... a common exploration of knowledge diversity. This exploration of knowledge diversity is important for higher education both in Africa and in the Global North....

  12. Anfal and Modernity: A Paradoxical Study of Modernity

    Directory of Open Access Journals (Sweden)

    R. Abbastabar

    2016-07-01

    Full Text Available This paper attempts to enter the fields of history, sociology and political sciences and finds a link between their theoretical and practical bases. Therefore, the main concern in this paper is to find the relationship between Anfal (a historical and socio-political event and modernism (a political-philosophical concept. It attempts to find out if Anfal or the genocide of the Iraqi Kurds has any relationship with modernism and if it can be considered as a by-product of modernism. By explaining the concept of modernism and highlighting the paradoxes in it, this paper examines Anfal vs-a-vis these paradoxes. To answer research questions of the theory of modernism theory and its critical attitude one has to depend on data analysis and use of the descriptive analytical method. The hypothesis in this study is that Anfal is the product of modernism. Findings of the study show that Anfal is the product of the paradoxes in modernism and modernism while encountering Anfal has shown its dark side. Fatalism is an aspect which has developed as a result of instrumental rationality which in itself is an outcome of modernism.The instrumental rationality has brought with itbureaucracy, army and technology as a result of which government fell in the hands of the Baath Partywhich was the direct product of Anfal.

  13. Solution of Supplee's submarine paradox through special and general relativity

    CERN Document Server

    Vieira, R S

    2016-01-01

    In 1989 Supplee described an apparent relativistic paradox on which a submarine seems to sink in a given frame while floating in another one. If the submarine density is adjusted to be the same as the water density (when both of them are at rest) and then it is put to move, the density of the submarine will become higher than that of the water, thanks to Lorentz contraction, and hence it sinks. However, in the submarine proper frame, is the water that becomes denser, so the submarine supposedly should float and we get a paradox situation. In this paper we analyze the submarine paradox in both a flat and a curved spacetime. In the case of a flat spacetime, we first show that any relativistic force field in special relativity can be written in the Lorentz form, so that it can always be decomposed into a static (electric-like) and a dynamic (magnetic-like) part. Taking into account the gravitomagnetic effects between the Earth and the water, a relativistic formulation of Archimedes principle can be established, ...

  14. Paradoxical response during antituberculous treatment for abdominal tuberculosis

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ji Young; Kwon, Jung Hyeok; Kim, Mi Jeong; Chang, Hyuk Won; Hwang, Jae Seok; Cho, Kwang Bum; Park, Kyung Sik; Jang, Byoung Kuk; Chung, Woo Jin [Dongsan Medical Center, Keimyung University School of Medicine, Daegu (Korea, Republic of)

    2006-12-15

    The purpose of our study was to evaluate clinical and CT findings of paradoxical response during treatment for abdominal tuberculosis. Authors reviewed the patient records of 138 patients with abdominal tuberculosis during a recent 6-year period and we selected 11 patients with a paradoxical response. The CT findings and pathologic findings of the initial lesions and new lesions were reviewed. The intervals between initiation of therapy and the detection of new lesions, improvement of new lesion and the final follow-up were evaluated. At the initial presentation, we identified tuberculous peritonitis in 8 patients, tuberculous lymphadenitis in 3 patients and ileocolic tuberculosis in two patients. New lesions were identified at 2-10 months (mean: 3.8 months) after the initiation of therapy and following improvement of the initial lesions. The new lesions were perihepatic caseous abscess (n=4), hepatic tuberculoma (n=3), hepatic caseous abscess (n=1), tuberculous lymphadenitis (n=3), ileocolic tuberculosis (n=3), and splenic tuberculoma (n=1). Improvement of new lesions was noted at 4-14 months (mean: 7.6 months). At the final follow-up of seven patients, the new lesions disappeared and four patients still had small residual lesions. New lesions that develop in a patient with initial improvement should be considered a paradoxical response that will ultimately improve with continuation of the original medication.

  15. The diagnosis and treatment of paradoxical embolism: a systematic review

    Directory of Open Access Journals (Sweden)

    Atooshe Rohani

    2016-11-01

    Full Text Available One in five adults has patent foramen ovale (PFO, which is typically without symptoms. Because of the low pressure in both atria and the anatomical position of the septum secundum, there is no left-to-right shunting and little right-to-left shunting in the general condition; however, when the right atrial pressure increases, this slit-like flap separates and allows right-to-left shunting. According to the Johnson criteria, simultaneous occurrences of arterial emboli, such as those caused by cerebrovascular accident or pulmonary embolism, demonstrate the presence of paradoxical embolism through a PFO. When a patient presents with multivascular arterial embolism, the clinician should perform a contrast transthoracic echo, a transesophageal (TEE, a real-time three-dimensional TEE, and even an intracardiac echocardiography (ICE in order to differentiate between PFO, flat atrial septal defect (ASD and hybrid defects. The randomized trials that have assessed therapeutic interventions for paradoxical embolism have not produced any clear guidelines as to how best to treat this condition. The classic treatment is surgical embolectomy with exploration of the right chambers and the pulmonary arteries under full cardiopulmonary bypass. Patients with a history of ≥1 paradoxical embolism may be indicated for device PFO closure.

  16. Emergent geometry, emergent forces

    Science.gov (United States)

    Selesnick, S. A.

    2017-10-01

    We give a brief account of some aspects of Finkelstein’s quantum relativity, namely an extension of it that derives elements of macroscopic geometry and the Lagrangians of the standard model including gravity from a presumed quantum version of spacetime. These emerge as collective effects in this quantal substrate. Our treatment, which is largely self-contained, differs mathematically from that originally given by Finkelstein. Dedicated to the memory of David Ritz Finkelstein

  17. Differential diagnosis in paradoxical vocal fold movement (PVFM): an interdisciplinary task.

    Science.gov (United States)

    Franca, Maria Claudia

    2014-12-01

    The objective of this study was to contribute to the discussion of differential diagnosis in paradoxical vocal fold movement (PVFM), a disorder frequently associated with episodes of breathing difficulty and stridor. Because of analogous respiratory symptoms, PVFM is often misdiagnosed as asthma. Additional evidence suggests the association of factors such as respiratory struggle during physical exertion, digestive reflux, and respiratory allergies with PVFM, particularly in athletes and young females. Interdisciplinary attention is warranted to avoid unnecessary utilization of medical resources and potential delay in the application of proper treatment. A description of critical points in PVFM differential diagnosis is proposed, featuring the assessment of a seven-year-old female with a history of behaviors considered to exacerbate voice fatigue symptoms. Noticeably, the child has consistently demonstrated tiredness and respiratory difficulties during physical education classes. Past use of oral steroids to reduce respiratory problems was applied with no improvement; short-acting beta 2-agonists have been also tried with mild improvement. Indications of instability and effort associated with respiratory-phonatory functions were demonstrated. Furthermore, there was evidence of GERD and seasonal allergies. The literature suggests an association of factors such as respiratory struggle during physical exertion, unwanted vocal effort, GERD, and respiratory allergies in individuals with PVFM, particularly in young females. A diagnosis of PVFM was suggested, in association with paradoxical vocal folds motion caused by respiratory difficulties verified by laryngeal examination. In PVFM, the vocal folds adduct during inhalation, thereby restricting the airway opening. Inconsistent vocal folds movement during phonation may also lead to PVFM symptoms. Acute bronchospasm/asthma-like symptoms, as well as additional morbidity may impact accuracy of diagnosis, leading to

  18. The Self-Help Book in the Therapeutic Ontosphere: A Postmodern Paradox

    Directory of Open Access Journals (Sweden)

    Jean Collingsworth

    2014-10-01

    Full Text Available he self-help book is a prominent cultural and commercial phenomenon in the therapeutic ontosphere which permeates contemporary life. The generic term 'ontosphere' is here co-opted from IT to describe a notional social space in which influential conceptualisations and shared assumptions about personal values and enti-tlements operate without interrogation in the demotic apprehension of "reality". It thus complements the established critical terms 'discourse' and 'episteme'. In the therapeutic ontosphere the normal vicissitudes of life are increasingly interpreted as personal catastrophes. As new issues of concern are defined, it is assumed that an individual will need help to deal with them and live successfully. Advice-giving has become big business and the self-help book is now an important post-modern commodity. However a paradox emerges when the content and ideology of this apparently postmodern artifact is examined. In its topical eclecticism the genre is indeed unaligned with those traditional 'grand narratives' and collective value systems which the postmodern critical project has sought to discredit. It endorses relativism, celebrates reflexivity and valorizes many kinds of 'personal truth'. Moreover readers are encouraged towards self-renovation through a process of 'bricolage' which involves selecting advice from a diverse ethical menu along-side which many 'little narratives' of localized lived experience are presented as supportive exemplars. However in asserting the pragmatic power of individual instrumentality in an episteme which has seen the critical decentering of the human subject, the self-help book perpetuates the liberal-humanist notion of an essential personal identity whose stable core is axiomatic in traditional ethical advice. And the heroic journey of self-actualization is surely the grandest of grand narratives: the monomyth. Thus the telic self-help book presents the critical theorist with something of a paradox.

  19. Battling Arrow's Paradox to Discover Robust Water Management Alternatives

    Science.gov (United States)

    Kasprzyk, J. R.; Reed, P. M.; Hadka, D.

    2013-12-01

    This study explores whether or not Arrow's Impossibility Theorem, a theory of social choice, affects the formulation of water resources systems planning problems. The theorem discusses creating an aggregation function for voters choosing from more than three alternatives for society. The Impossibility Theorem is also called Arrow's Paradox, because when trying to add more voters, a single individual's preference will dictate the optimal group decision. In the context of water resources planning, our study is motivated by recent theoretical work that has generalized the insights for Arrow's Paradox to the design of complex engineered systems. In this framing of the paradox, states of society are equivalent to water planning or design alternatives, and the voters are equivalent to multiple planning objectives (e.g. minimizing cost or maximizing performance). Seen from this point of view, multi-objective water planning problems are functionally equivalent to the social choice problem described above. Traditional solutions to such multi-objective problems aggregate multiple performance measures into a single mathematical objective. The Theorem implies that a subset of performance concerns will inadvertently dictate the overall design evaluations in unpredictable ways using such an aggregation. We suggest that instead of aggregation, an explicit many-objective approach to water planning can help overcome the challenges posed by Arrow's Paradox. Many-objective planning explicitly disaggregates measures of performance while supporting the discovery of the planning tradeoffs, employing multiobjective evolutionary algorithms (MOEAs) to find solutions. Using MOEA-based search to address Arrow's Paradox requires that the MOEAs perform robustly with increasing problem complexity, such as adding additional objectives and/or decisions. This study uses comprehensive diagnostic evaluation of MOEA search performance across multiple problem formulations (both aggregated and many

  20. Paradoxical reaction to antituberculosis therapy in a patient with lupus vulgaris.

    Science.gov (United States)

    Santesteban, R; Bonaut, B; Córdoba, A; Yanguas, I

    2015-03-01

    Patients receiving treatment for tuberculosis may experience an unexpected deterioration of their disease; this is known as a paradoxical reaction. We present the case of a 59-year-old man with lupus vulgaris who experienced a paradoxical deterioration of cutaneous lesions after starting antituberculosis therapy. The reaction was self-limiting; the lesions gradually improved, and the final outcome was very good. Paradoxical reactions are well-known in patients with human immunodeficiency virus (HIV) infection who start antiretroviral therapy, but they can also occur in non-HIV-infected patients with tuberculosis who start antituberculosis therapy. In the literature reviewed, paradoxical reactions involving skin lesions were described in patients with miliary tuberculosis. The case we report is the first of a paradoxical reaction in lupus vulgaris. The increasing frequency of tuberculosis in Spain could lead to a rise in the number of paradoxical reactions. Copyright © 2014 Elsevier España, S.L.U. y AEDV. All rights reserved.

  1. The paradoxical construction of reality A paradoxal construção da realidade

    Directory of Open Access Journals (Sweden)

    Márcia Landsmann

    2009-06-01

    Full Text Available : The paradoxical construction of reality — Strange facts published in the newspapers of reference, herein called 'news of the fantastic', make up the corpus of this research project. Strangeness is presented as a news value exploited in journalism according to its degree of fantasticality. Starting from the premise that the sender-recipient relationship is a dynamic process of co-creation of meanings, the author observes the language games and the cons- truction of meaning in the communicative act triggered by journalistic statements. The study reveals that the editors reassert their authority through the aesthetics of the fantastic and that the strategy of seduction consists of presenting 'strange phenomena' occurring in 'unreal' worlds and then explaining or ironizing them, thereby rescuing the reader from this universe and returning him to the safety and order of the 'real world'. Fatos insólitos, aqui chamados de "notícias do fantástico", publicados nos jornais de referência compõem o corpus de trabalho da pesquisa. O insólito é apresentado como um valor/notícia explorado nos relatos jornalísticos conforme seu grau de inusitabilidade. Partindo do princípio de que a relação emissor/destinatário é um processo dinâmico de co-criação de sentidos, o autor observa os jogos de linguagem e a construção de sentidos no ato comunicativo desencadeado pelos enunciados jornalísticos. O estudo revela que os editores reafirmam sua autoridade por meio da estética do fantástico e que a estratégia da sedução consiste em apresentar "estranhos fenômenos" ocorridos em mundos "irreais" para, em seguida, explicá-lo ou ironizá-lo, resgatando o leitor deste universo e posicioná-lo diante da segurança e da ordem do "mundo real".

  2. Emergency contraception

    Science.gov (United States)

    Morning-after pill; Postcoital contraception; Birth control - emergency; Plan B; Family planning - emergency contraception ... Emergency contraception most likely prevents pregnancy in the same way as regular birth control pills: By preventing ...

  3. Neurohemodynamic Correlates of Washing Symptoms in Obsessive-compulsive Disorder: A Pilot fMRI Study Using Symptom Provocation Paradigm

    Science.gov (United States)

    Agarwal, Sri Mahavir; Jose, Dania; Baruah, Upasana; Shivakumar, Venkataram; Kalmady, Sunil Vasu; Venkatasubramanian, Ganesan; Mataix-Cols, David; Reddy, Yemmigannur Chandrashekhar Janardhan

    2013-01-01

    Background: Obsessive-compulsive disorder (OCD) is increasingly being viewed as a multidimensional heterogeneous disorder caused due to the dysfunction of several closely related, overlapping frontostriatal circuits. A study investigating the dimensional construct in treatment naïve, co-morbidity free patients with identical handedness is likely to provide the necessary homogeneity and power to elicit neural correlates of the various symptom dimensions, and overcome the limitations of previous studies. Materials and Methods: Nine DSM-IV OCD patients with predominant contamination-related obsessive-compulsive symptoms (age=29.8±7.1 years; five males: four females; years-of-education=13.9±1.6, YBOCS total score=28.8±4.7, DYBOCS Contamination dimension score=10.7±1.8) and nine healthy controls matched one to one with the patients for age, sex, and years of education (age=27.8±5.4, five males: four females; years-of-education=14.9±3.0), were examined during symptom provocation task performance in 3TMRI. Paired samples t test of brain activation differences (contamination relevant pictures – neutral pictures), limited to apriori regions of interest was done using SPM8 (uncorrected P<0.005). Results: Patients found significantly more pictures to be anxiety provoking in comparison to healthy controls. Patients were found to have deficient activation in the following areas in comparison with healthy controls: bilateral anterior prefrontal, dorsolateral prefrontal, orbitofrontal, anterior cingulate, insular and parietal cortices, precuneus, and caudate. Conclusions: Results underscore the importance of frontal, striatal, parietal, and occipital areas in the pathophysiology of OCD. Divergence of findings from previous studies might be attributed to the absence of confounding factors in the current study and may be due to production of intense anxiety in patients. PMID:23833345

  4. Neurohemodynamic Correlates of Washing Symptoms in Obsessive-compulsive Disorder: A Pilot fMRI Study Using Symptom Provocation Paradigm.

    Science.gov (United States)

    Agarwal, Sri Mahavir; Jose, Dania; Baruah, Upasana; Shivakumar, Venkataram; Kalmady, Sunil Vasu; Venkatasubramanian, Ganesan; Mataix-Cols, David; Reddy, Yemmigannur Chandrashekhar Janardhan

    2013-01-01

    Obsessive-compulsive disorder (OCD) is increasingly being viewed as a multidimensional heterogeneous disorder caused due to the dysfunction of several closely related, overlapping frontostriatal circuits. A study investigating the dimensional construct in treatment naïve, co-morbidity free patients with identical handedness is likely to provide the necessary homogeneity and power to elicit neural correlates of the various symptom dimensions, and overcome the limitations of previous studies. Nine DSM-IV OCD patients with predominant contamination-related obsessive-compulsive symptoms (age=29.8±7.1 years; five males: four females; years-of-education=13.9±1.6, YBOCS total score=28.8±4.7, DYBOCS Contamination dimension score=10.7±1.8) and nine healthy controls matched one to one with the patients for age, sex, and years of education (age=27.8±5.4, five males: four females; years-of-education=14.9±3.0), were examined during symptom provocation task performance in 3TMRI. Paired samples t test of brain activation differences (contamination relevant pictures - neutral pictures), limited to apriori regions of interest was done using SPM8 (uncorrected P<0.005). Patients found significantly more pictures to be anxiety provoking in comparison to healthy controls. Patients were found to have deficient activation in the following areas in comparison with healthy controls: bilateral anterior prefrontal, dorsolateral prefrontal, orbitofrontal, anterior cingulate, insular and parietal cortices, precuneus, and caudate. Results underscore the importance of frontal, striatal, parietal, and occipital areas in the pathophysiology of OCD. Divergence of findings from previous studies might be attributed to the absence of confounding factors in the current study and may be due to production of intense anxiety in patients.

  5. Aspirin provocation increases 8-iso-PGE2 in exhaled breath condensate of aspirin-hypersensitive asthmatics.

    Science.gov (United States)

    Mastalerz, Lucyna; Januszek, Rafał; Kaszuba, Marek; Wójcik, Krzysztof; Celejewska-Wójcik, Natalia; Gielicz, Anna; Plutecka, Hanna; Oleś, Krzysztof; Stręk, Paweł; Sanak, Marek

    2015-09-01

    Isoprostanes are bioactive compounds formed by non-enzymatic oxidation of polyunsaturated fatty acids, mostly arachidonic, and markers of free radical generation during inflammation. In aspirin exacerbated respiratory disease (AERD), asthmatic symptoms are precipitated by ingestion of non-steroid anti-inflammatory drugs capable for pharmacologic inhibition of cyclooxygenase-1 isoenzyme. We investigated whether aspirin-provoked bronchoconstriction is accompanied by changes of isoprostanes in exhaled breath condensate (EBC). EBC was collected from 28 AERD subjects and 25 aspirin-tolerant asthmatics before and after inhalatory aspirin challenge. Concentrations of 8-iso-PGF2α, 8-iso-PGE2, and prostaglandin E2 were measured using gas chromatography/mass spectrometry. Leukotriene E4 was measured by immunoassay in urine samples collected before and after the challenge. Before the challenge, exhaled 8-iso-PGF2α, 8-iso-PGE2, and PGE2 levels did not differ between the study groups. 8-iso-PGE2 level increased in AERD group only (p=0.014) as a result of the aspirin challenge. Urinary LTE4 was elevated in AERD, both in baseline and post-challenge samples. Post-challenge airways 8-iso-PGE2 correlated positively with urinary LTE4 level (p=0.046), whereas it correlated negatively with the provocative dose of aspirin (p=0.027). A significant increase of exhaled 8-iso-PGE2 after inhalatory challenge with aspirin was selective and not present for the other isoprostane measured. This is a novel finding in AERD, suggesting that inhibition of cyclooxygenase may elicit 8-iso-PGE2 production in a specific mechanism, contributing to bronchoconstriction and systemic overproduction of cysteinyl leukotrienes. Copyright © 2015 Elsevier Inc. All rights reserved.

  6. Ophthalmic emergencies.

    Science.gov (United States)

    Mandell, Deborah C; Holt, Elaine

    2005-03-01

    Ophthalmic emergencies are common presenting complaints in an emergency room. Most ophthalmic emergencies can be treated and stabilized until an ophthalmologist can be consulted. Most ocular emergencies involve loss of vision, compromised globe integrity, or severe ocular pain. Delay in treating true emergencies may result ina blind eye or loss of an eye. This article discusses the clinical signs,diagnosis, and treatment as well as the prognosis of some of the more common ophthalmic emergencies.

  7. Entrepreneurship, Emerging Technologies, Emerging Markets

    NARCIS (Netherlands)

    Thukral, Inderpreet S.; Von Ehr, James; Walsh, Steven Thomas; Groen, Arend J.; van der Sijde, Peter; Adham, Khairul Akmaliah

    2008-01-01

    Academics and practitioners alike have long understood the benefits, if not the risks, of both emerging markets and emerging technologies.Yet it is only recently that foresighted firms have embraced emerging technologies and emerging markets through entrepreneurial activity. Emerging technologies

  8. Energy flow in a bound electromagnetic field: resolution of apparent paradoxes

    Energy Technology Data Exchange (ETDEWEB)

    Kholmetskii, A L [Department of Physics, Belarusian State University, 4, Nezavisimosti Avenue, 220050 Minsk (Belarus); Yarman, T [Department of Engineering, Okan University Istanbul, Turkey and Savronik, Eskisehir (Turkey)], E-mail: kholm@bsu.by

    2008-11-15

    In this paper, we present a resolution of apparent paradoxes formulated in (Kholmetskii A L 2006 Apparent paradoxes in classical electrodynamics: the energy-momentum conservation law for a bound electromagnetic field Eur. J. Phys. 27 825-38; Kholmetskii A L and Yarman T 2008 Apparent paradoxes in classical electrodynamics: a fluid medium in an electromagnetic field Eur. J. Phys. 29 1127) and dealing with the energy flux in a bound electromagnetic field.

  9. Paradoxical intention in the treatment of agoraphobia and other anxiety disorders.

    Science.gov (United States)

    Michelson, L; Ascher, L M

    1984-09-01

    Following a description of the paradoxical intention procedure and a brief review of the general behavioral literature relevant to this technique, the authors focus on the role of paradoxical treatment programs for agoraphobic clients. The cognitive and exposure components of paradoxical intention are discussed and the procedure is compared and contrasted with other cognitive behavioral methods on one hand, and with flooding on the other. Finally, the authors provide several ideas for future research.

  10. On Hardy's paradox, weak measurements, and multitasking diagrams

    Energy Technology Data Exchange (ETDEWEB)

    Meglicki, Zdzislaw, E-mail: gustav@indiana.edu [Indiana University, Office of the Vice President for Information Technology, 601 E. Kirkwood Ave., Room 116, Bloomington, IN 47405-1223 (United States)

    2011-07-04

    We discuss Hardy's paradox and weak measurements by using multitasking diagrams, which are introduced to illustrate the progress of quantum probabilities through the double interferometer system. We explain how Hardy's paradox is avoided and elaborate on the outcome of weak measurements in this context. -- Highlights: → Hardy's paradox explained and eliminated. → Weak measurements: what is really measured? → Multitasking diagrams: introduced and used to discuss quantum mechanical processes.

  11. Sheldon Spectrum and the Plankton Paradox: Two Sides of the Same Coin. A trait-based plankton size-spectrum model

    CERN Document Server

    Cuesta, José A; Law, Richard

    2016-01-01

    The Sheldon spectrum describes a remarkable regularity in aquatic ecosystems: the biomass density as a function of logarithmic body mass is approximately constant over many orders of magnitude. While size-spectrum models have explained this phenomenon for assemblages of multicellular organisms, this paper introduces a species-resolved size-spectrum model to explain the phenomenon in unicellular plankton. A Sheldon spectrum spanning the cell-size range of unicellular plankton necessarily consists of a large number of coexisting species covering a wide range of characteristic sizes. The coexistence of many phytoplankton species feeding on a small number of resources is known as the Paradox of the Plankton. Our model resolves the paradox by showing that coexistence is facilitated by the allometric scaling of four physiological rates. Two of the allometries have empirical support, the remaining two emerge from predator-prey interactions exactly when the abundances follow a Sheldon spectrum. Our plankton model is ...

  12. Paradoxical Benzodiazepine Response: A Rationale for Bumetanide in Neurodevelopmental Disorders?

    Science.gov (United States)

    Bruining, Hilgo; Passtoors, Laurien; Goriounova, Natalia; Jansen, Floor; Hakvoort, Britt; de Jonge, Maretha; Poil, Simon-Shlomo

    2015-08-01

    The diuretic agent bumetanide has recently been put forward as a novel, promising treatment of behavioral symptoms in autism spectrum disorder (ASD) and related conditions. Bumetanide can decrease neuronal chloride concentrations and may thereby reinstate γ-aminobutyric acid (GABA)-ergic inhibition in patients with neurodevelopmental disorders. However, strategies to select appropriate candidates for bumetanide treatment are lacking. We hypothesized that a paradoxical response to GABA-enforcing agents such as benzodiazepines may predict the efficacy of bumetanide treatment in neurodevelopmental disorders. We describe a case of a 10-year-old girl with ASD, epilepsy, cortical dysplasia, and a 15q11.2 duplication who had exhibited marked behavioral arousal after previous treatment with clobazam, a benzodiazepine. We hypothesized that this response indicated the presence of depolarizing excitatory GABA and started bumetanide treatment with monitoring of behavior, cognition, and EEG. The treatment resulted in a marked clinical improvement in sensory behaviors, rigidity, and memory performance, which was substantiated by questionnaires and cognitive assessments. At baseline, the girl's EEG showed a depression in absolute α power, an electrographic sign previously related to ASD, which was normalized with bumetanide treatment. The effects of bumetanide on cognition and EEG seemed to mirror the "nonparadoxical" responses to benzodiazepines in healthy subjects. In addition, temporal lobe epilepsy and cortical dysplasia have both been linked to disturbed chloride homeostasis and seem to support our assumption that the observed paradoxical response was due to GABA-mediated excitation. This case highlights that a paradoxical behavioral response to GABA-enforcing drugs may constitute a framework for targeted treatment with bumetanide. Copyright © 2015 by the American Academy of Pediatrics.

  13. Matrix- based logic for avoiding paradoxes and its paraconsistent alternative

    Directory of Open Access Journals (Sweden)

    Paul Weingartner

    2011-06-01

    Full Text Available The present article shows that there are consistent and decidable many- valued systems of propositional logic which satisfy two or all the three criteria for non- trivial inconsistent theories by da Costa (1974. The weaker one of these paraconsistent system is also able to avoid a series of paradoxes which come up when classical logic is applied to empirical sciences. These paraconsistent systems are based on a 6- valued system of propositional logic for avoiding difficulties in several domains of empirical science (Weingartner (2009.

  14. Retroflection from slanted coastlines-circumventing the "vorticity paradox"

    Directory of Open Access Journals (Sweden)

    V. Zharkov

    2008-12-01

    Full Text Available The balance of long-shore momentum flux requires that the solution of zonally retroflecting currents involve ring shedding on the western side. An important aspect of the ring dynamics is the ring intensity α (analogous to the Rossby number, which reaches its maximum value of unity when the upstream potential vorticity (PV is zero. Friction leads to a slow-down and a decrease in α. The main difficulty is that the solution of the system of equations for conservation of mass and momentum of zonal currents leads to the conclusion that the ratio (Φ of the mass flux going into the rings and the total incoming mass flux is approximately 4α/(1+2α. This yields the "vorticity paradox" – only relatively weak rings (α≤1/2 could satisfy the necessary condition Φ≤1. Physically, this means, for example, that the momentum-flux of zero PV currents upstream is so high that, no matter how many rings are produced and, no matter what size they are, they cannot compensate for it.

    To avoid this paradox, we develop a nonlinear analytical model of retroflection from a slanted non-zonal coastline. We show that when the slant of coastline (γ exceeds merely 150, Φ does not reach unity regardless of the value of α. Namely, the paradox disappears even for small slants. Our slowly varying nonlinear solution does not only let us circumvent the paradox. It also gives a detailed description of the rings growth rate and the mass flux going into the rings as a function of time. For example, in the case of zero PV and zero thickness of the upper layer along the coastline, the maximal values of Φ can be approximately expressed as, 1.012+0.32exp(−γ/3.41−γ/225. Interestingly, for significant slants γ≥300, the rings reach a terminal size corresponding to a balance between the β-force and both the upstream and downstream momentum fluxes. This terminal size is unrelated to the ultimate

  15. Relational Goods and Resolving the Paradox of Political Participation

    OpenAIRE

    Carole Uhlaner

    2014-01-01

    The fact that people engage in collective action is one of the more puzzling aspects of political behavior.  If one assumes that people rationally weigh benefits and costs, then analysis concludes that most people will choose inaction.   Since we observe many more members of the public participate than predicted, there is a contradiction, often thought of as a paradox.  We can, at least partially, solve the puzzle by acknowledging that people value relational goods.  These are goods which...

  16. [The paradoxical effect of persuasive communication in health education sessions].

    Science.gov (United States)

    Piperini, Marie-Christine

    2012-01-01

    The purpose of this study was to examine the communication dynamics leading to the adoption of new attitudes and cognitions in health education sessions. We examined the verbal interactions at work in persuasive communication in 16 health education sessions. The study found that the medical expertise of the educator and the initial level of commitment of the participants had a positive effect on adherence to recommendations. However, persuasive communication in health education sessions appears to involve a paradoxical process in which criticism of the message can go hand in hand with the expression of an intention to implement new risk-reducing behaviors.

  17. Generalized absorber theory and the Einstein-Podolsky-Rosen paradox

    Energy Technology Data Exchange (ETDEWEB)

    Cramer, J.G.

    1980-07-15

    A generalized form of Wheeler-Feynman absorber theory is used to explain the quantum-mechanical paradox proposed by Einstein, Podolsky, and Rosen (EPR). The advanced solutions of the electromagnetic wave equation and of relativistic quantum-mechanical wave equations are shown to play the role of ''verifier'' in quantum-mechanical ''transactions,'' providing microscopic communication paths between detectors across spacelike intervals in violation of the EPR locality postulate. The principle of causality is discussed in the context of this approach, and possibilities for experimental tests of the theory are examined.

  18. Twin paradox with macroscopic clocks in superconducting circuits

    Science.gov (United States)

    Lindkvist, Joel; Sabín, Carlos; Fuentes, Ivette; Dragan, Andrzej; Svensson, Ida-Maria; Delsing, Per; Johansson, Göran

    2014-11-01

    We propose an implementation of a twin-paradox scenario in superconducting circuits, with velocities as large as a few percent of the speed of light. Ultrafast modulation of the boundary conditions for the electromagnetic field in a microwave cavity simulates a clock moving at relativistic speeds. Since our cavity has a finite length, the setup allows us to investigate the role of clock size as well as interesting quantum effects on time dilation. In particular, our theoretical results show that the time dilation increases for larger cavity lengths and is shifted due to quantum particle creation.

  19. The twin paradox in the theory of relativity

    Science.gov (United States)

    Grøn, Ø.

    2006-07-01

    It is pointed out that a complete resolution of the twin paradox demands that the travelling twin takes into account the gravitational effect upon the rate of time when he predicts the ageing of his brother. Two ways of making this prediction are presented. The first one is formally very simple. However, it involves an assumption that is not obvious when the travelling twin stipulates the distance of his brother. The second method makes use of Lagrangian dynamics in a uniformly accelerated reference frame. Then no such assumption is necessary.

  20. he Impact of Economic Paradoxes on the Pharmaceutical Market Evolution

    Directory of Open Access Journals (Sweden)

    Doina MARGARITTI

    2012-11-01

    Full Text Available The population’s health represents the most important economic resource in a society. The social-economic role of heath protection is determined by the proper allocation of public financial resources but also partially, by the allocation of the populations own income. The general law of demand can be applied to the drugdemand. The well-knowneconomic paradoxes R. Giffen, T. Veblen and A. Rugina canbefound on the pharmaceuticalmarket and determine the elasticity of drug demand. The quantity of drugs needed to assure the populations health presents insignificant modifications to the price fluctuations, to the populations’ income, the resources allocated by the state and by each patient.