WorldWideScience

Sample records for proving ground md

  1. 78 FR 60238 - Proposed Modification and Establishment of Restricted Areas; Aberdeen Proving Ground, MD

    Science.gov (United States)

    2013-10-01

    ...; Aberdeen Proving Ground, MD AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed..., within the existing restricted areas R-4001A and R- 4001B, at the U.S. Army's Aberdeen Proving Ground in... nonparticipating aircraft from a hazard to navigation in the Aberdeen Proving Ground airspace. DATES: Comments must...

  2. 33 CFR 334.140 - Chesapeake Bay; U.S. Army Proving Ground Reservation, Aberdeen, Md.

    Science.gov (United States)

    2010-07-01

    ... Island to Locust Point; thence along straight line from Locust Point to Turkey Point for a distance of... right to land nor to cut or procure pound net poles or stakes on the Aberdeen Proving Ground Reservation...

  3. Renewable Energy Opportunties at Dugway Proving Ground, Utah

    Energy Technology Data Exchange (ETDEWEB)

    Orrell, Alice C.; Kora, Angela R.; Russo, Bryan J.; Horner, Jacob A.; Williamson, Jennifer L.; Weimar, Mark R.; Gorrissen, Willy J.; Nesse, Ronald J.; Dixon, Douglas R.

    2010-05-31

    This document provides an overview of renewable resource potential at Dugway Proving Ground, based primarily upon analysis of secondary data sources supplemented with limited on-site evaluations. This effort focuses on grid-connected generation of electricity from renewable energy sources and ground source heat pumps (GSHPs). The effort was funded by the U.S. Army Installation Management Command (IMCOM) as follow-on to the 2005 Department of Defense (DoD) Renewables Assessment.

  4. Unexploded ordnance issues at Aberdeen Proving Ground: Background information

    Energy Technology Data Exchange (ETDEWEB)

    Rosenblatt, D.H.

    1996-11-01

    This document summarizes currently available information about the presence and significance of unexploded ordnance (UXO) in the two main areas of Aberdeen Proving Ground: Aberdeen Area and Edgewood Area. Known UXO in the land ranges of the Aberdeen Area consists entirely of conventional munitions. The Edgewood Area contains, in addition to conventional munitions, a significant quantity of chemical-munition UXO, which is reflected in the presence of chemical agent decomposition products in Edgewood Area ground-water samples. It may be concluded from current information that the UXO at Aberdeen Proving Ground has not adversely affected the environment through release of toxic substances to the public domain, especially not by water pathways, and is not likely to do so in the near future. Nevertheless, modest but periodic monitoring of groundwater and nearby surface waters would be a prudent policy.

  5. Preparing for Mars: The Evolvable Mars Campaign 'Proving Ground' Approach

    Science.gov (United States)

    Bobskill, Marianne R.; Lupisella, Mark L.; Mueller, Rob P.; Sibille, Laurent; Vangen, Scott; Williams-Byrd, Julie

    2015-01-01

    As the National Aeronautics and Space Administration (NASA) prepares to extend human presence beyond Low Earth Orbit, we are in the early stages of planning missions within the framework of an Evolvable Mars Campaign. Initial missions would be conducted in near-Earth cis-lunar space and would eventually culminate in extended duration crewed missions on the surface of Mars. To enable such exploration missions, critical technologies and capabilities must be identified, developed, and tested. NASA has followed a principled approach to identify critical capabilities and a "Proving Ground" approach is emerging to address testing needs. The Proving Ground is a period subsequent to current International Space Station activities wherein exploration-enabling capabilities and technologies are developed and the foundation is laid for sustained human presence in space. The Proving Ground domain essentially includes missions beyond Low Earth Orbit that will provide increasing mission capability while reducing technical risks. Proving Ground missions also provide valuable experience with deep space operations and support the transition from "Earth-dependence" to "Earth-independence" required for sustainable space exploration. A Technology Development Assessment Team identified a suite of critical technologies needed to support the cadence of exploration missions. Discussions among mission planners, vehicle developers, subject-matter-experts, and technologists were used to identify a minimum but sufficient set of required technologies and capabilities. Within System Maturation Teams, known challenges were identified and expressed as specific performance gaps in critical capabilities, which were then refined and activities required to close these critical gaps were identified. Analysis was performed to identify test and demonstration opportunities for critical technical capabilities across the Proving Ground spectrum of missions. This suite of critical capabilities is expected to

  6. Evaluation of depleted uranium in the environment at Aberdeen Proving Grounds, Maryland and Yuma Proving Grounds, Arizona. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Kennedy, P.L.; Clements, W.H.; Myers, O.B.; Bestgen, H.T.; Jenkins, D.G. [Colorado State Univ., Fort Collins, CO (United States). Dept. of Fishery and Wildlife Biology

    1995-01-01

    This report represents an evaluation of depleted uranium (DU) introduced into the environment at the Aberdeen Proving Grounds (APG), Maryland and Yuma Proving Grounds (YPG) Arizona. This was a cooperative project between the Environmental Sciences and Statistical Analyses Groups at LANL and with the Department of Fishery and Wildlife Biology at Colorado State University. The project represents a unique approach to assessing the environmental impact of DU in two dissimilar ecosystems. Ecological exposure models were created for each ecosystem and sensitivity/uncertainty analyses were conducted to identify exposure pathways which were most influential in the fate and transport of DU in the environment. Research included field sampling, field exposure experiment, and laboratory experiments. The first section addresses DU at the APG site. Chapter topics include bioenergetics-based food web model; field exposure experiments; bioconcentration by phytoplankton and the toxicity of U to zooplankton; physical processes governing the desorption of uranium from sediment to water; transfer of uranium from sediment to benthic invertebrates; spead of adsorpion by benthic invertebrates; uptake of uranium by fish. The final section of the report addresses DU at the YPG site. Chapters include the following information: Du transport processes and pathway model; field studies of performance of exposure model; uptake and elimination rates for kangaroo rates; chemical toxicity in kangaroo rat kidneys.

  7. Environmental geophysics, offshore Bush River Peninsula, Aberdeen Proving Ground, Maryland

    Energy Technology Data Exchange (ETDEWEB)

    Miller, S.F.; Kuecher, G.J.; Davies, B.E. [and others

    1995-11-01

    Geophysical studies in shallow waters adjacent to the Bush River Peninsula, Edgewood Area of Aberdeen Proving Ground, Maryland, have delineated the extent of waste disposal sites and established a hydrogeologic framework, which may control contaminant transport offshore. These studies indicate that during the Pleistocene Epoch, alternating stands of high and low sea levels resulted in a complex pattern of shallow channel-fill deposits around the Bush River Peninsula. Ground-penetrating radar studies reveal paleochannels greater than 50 ft deep. Some of the paleochannels are also imaged with marine seismic reflection. Conductivity highs measured with the EM-31 are also indicative of paleochannels. This paleochannel depositional system is environmentally significant because it may control the shallow groundwater flow regime beneath the peninsula. Magnetic, conductivity, and side-scan sonar anomalies outline anthropogenic anomalies in the study area. On the basis of geophysical data, underwater anthropogenic materials do exist in some isolated areas, but large-scale offshore dumping has not occurred in the area studied.

  8. NASA SPoRT GOES-R Proving Ground Activities

    Science.gov (United States)

    Stano, Geoffrey T.; Fuell, Kevin K.; Jedloec, Gary J.

    2010-01-01

    The NASA Short-term Prediction Research and Transition (SPoRT) program is a partner with the GOES-R Proving Ground (PG) helping prepare forecasters understand the unique products to come from the GOES-R instrument suite. SPoRT is working collaboratively with other members of the GOES-R PG team and Algorithm Working Group (AWG) scientists to develop and disseminate a suite of proxy products that address specific forecast problems for the WFOs, Regional and National Support Centers, and other NOAA users. These products draw on SPoRT s expertise with the transition and evaluation of products into operations from the MODIS instrument and the North Alabama Lightning Mapping Array (NALMA). The MODIS instrument serves as an excellent proxy for the Advanced Baseline Imager (ABI) that will be aboard GOES-R. SPoRT has transitioned and evaluated several multi-channel MODIS products. The true and false color products are being used in natural hazard detection by several SPoRT partners to provide better observation of land features, such as fires, smoke plumes, and snow cover. Additionally, many of SPoRT s partners are coastal offices and already benefit from the MODIS sea surface temperature composite. This, along with other surface feature observations will be developed into ABI proxy products for diagnostic use in the forecast process as well as assimilation into forecast models. In addition to the MODIS instrument, the NALMA has proven very valuable to WFOs with access to these total lightning data. These data provide situational awareness and enhanced warning decision making to improve lead times for severe thunderstorm and tornado warnings. One effort by SPoRT scientists includes a lightning threat product to create short-term model forecasts of lightning activity. Additionally, SPoRT is working with the AWG to create GLM proxy data from several of the ground based total lightning networks, such as the NALMA. The evaluation will focus on the vastly improved spatial

  9. The GOES-R Proving Ground: 2012 Update

    Science.gov (United States)

    Gurka, J.; Goodman, S. J.; Schmit, T.; Demaria, M.; Mostek, A.; Siewert, C.; Reed, B.

    2011-12-01

    The Geostationary Operational Environmental Satellite (GOES)-R will provide a great leap forward in observing capabilities, but will also offer a significant challenge to ensure that users are ready to exploit the vast improvements in spatial, spectral, and temporal resolutions. To ensure user readiness, forecasters and other users must have access to prototype advanced products well before launch, and have the opportunity to provide feedback to product developers and computing and communications managers. The operational assessment is critical to ensure that the end products and NOAA's computing and communications systems truly meet their needs in a rapidly evolving environment. The GOES-R Proving Ground (PG) engages the National Weather Service (NWS) forecast, watch and warning community and other agency users in pre-operational demonstrations of select products with GOES-R attributes (enhanced spectral, spatial, and temporal resolution). In the PG, developers and forecasters test and apply algorithms for new GOES-R satellite data and products using proxy and simulated data sets, including observations from current and future satellite instruments (MODIS, AIRS, IASI, SEVIRI, NAST-I, NPP/VIIRS/CrIS, LIS), lightning networks, and computer simulated products. The complete list of products to be evaluated in 2012 will be determined after evaluating results from experiments in 2011 at the NWS' Storm Prediction Center, National Hurricane Center, Aviation Weather Center, Ocean Prediction Center, Hydrometeorological Prediction Center, and from the six NWS regions. In 2012 and beyond, the PG will test and validate data processing and distribution systems and the applications of these products in operational settings. Additionally developers and forecasters will test and apply display techniques and decision aid tools in operational environments. The PG is both a recipient and a source of training. Training materials are developed using various distance training tools in

  10. Pacific Proving Grounds radioisotope imprint in the Philippine Sea sediments.

    Science.gov (United States)

    Pittauer, Daniela; Roos, Per; Qiao, Jixin; Geibert, Walter; Elvert, Marcus; Fischer, Helmut W

    2018-06-01

    Radionuclide concentrations were studied in sediment cores taken at the continental slope of the Philippine Sea off Mindanao Island in the equatorial Western Pacific. High resolution deposition records of anthropogenic radionuclides were collected at this site. Excess 210 Pb together with excess 228 Th and anthropogenic radionuclides provided information about accumulation rates. Concentrations of Am and Pu isotopes were detected by gamma spectrometry, alpha spectrometry and ICP-MS. The Pu ratios indicate a high portion (minimum of 60%) of Pu from the Pacific Proving Grounds (PPG). This implies that the transport of PPG derived plutonium with the Mindanao Current southward is similarly effective as the previously known transport towards the north with the Kuroshio Current. The record is compared to other studies from northwest Pacific marginal seas and Lombok basin in the Indonesian Archipelago. The sediment core top was found to contain a 6 cm thick layer dominated by terrestrial organic matter, which was interpreted as a result of the 2012 Typhoon Pablo-related fast deposition. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. Ground-water flow and the possible effects of remedial actions at J-Field, Aberdeen Proving Ground, Maryland

    Science.gov (United States)

    Hughes, W.B.

    1995-01-01

    J-Field, located in the Edgewood Area of Aberdeen Proving Ground, Md, has been used since World War II to test and dispose of explosives, chemical warfare agents, and industrial chemicals resulting in ground-water, surface-water, and soil contami- nation. The U.S. Geological Survey finite-difference model was used to better understand ground-water flow at the site and to simulate the effects of remedial actions. A surficial aquifer and a confined aquifer were simulated with the model. A confining unit separates these units and is represented by leakance between the layers. The area modeled is 3.65 mi2; the model was constructed with a variably spaced 40 X 38 grid. The horizontal and lower boundaries of the model are all no-flow boundaries. Steady-state conditions were used. Ground water at the areas under investigation flows from disposal pit areas toward discharge areas in adjacent estuaries or wetlands. Simulations indicate that capping disposal areas with an impermeable cover effectively slows advective ground water flow by 0.7 to 0.5 times. Barriers to lateral ground-water flow were simulated and effectively prevented the movement of ground water toward discharge areas. Extraction wells were simulated as a way to contain ground-water contamination and to extract ground water for treatment. Two wells pumping 5 gallons per minute each at the toxic-materials disposal area and a single well pumping 2.5 gallons per minute at the riot-control-agent disposal area effectively contained contamination at these sites. A combi- nation of barriers to horizontal flow east and south of the toxic-materials disposal area, and a single extraction well pumping at 5 gallons per minute can extract contaminated ground water and prevent pumpage of marsh water.

  12. Depleted uranium human health risk assessment, Jefferson Proving Ground, Indiana

    Energy Technology Data Exchange (ETDEWEB)

    Ebinger, M.H.; Hansen, W.R.

    1994-04-29

    The risk to human health from fragments of depleted uranium (DU) at Jefferson Proving Ground (JPG) was estimated using two types of ecosystem pathway models. A steady-state, model of the JPG area was developed to examine the effects of DU in soils, water, and vegetation on deer that were hunted and consumed by humans. The RESRAD code was also used to estimate the effects of farming the impact area and consuming the products derived from the farm. The steady-state model showed that minimal doses to humans are expected from consumption of deer that inhabit the impact area. Median values for doses to humans range from about 1 mrem ({plus_minus}2.4) to 0.04 mrem ({plus_minus}0.13) and translate to less than 1 {times} 10{sup {minus}6} detriments (excess cancers) in the population. Monte Carlo simulation of the steady-state model was used to derive the probability distributions from which the median values were drawn. Sensitivity analyses of the steady-state model showed that the amount of DU in airborne dust and, therefore, the amount of DU on the vegetation surface, controlled the amount of DU ingested by deer and by humans. Human doses from the RESRAD estimates ranged from less than 1 mrem/y to about 6.5 mrem/y in a hunting scenario and subsistence fanning scenario, respectively. The human doses exceeded the 100 mrem/y dose limit when drinking water for the farming scenario was obtained from the on-site aquifer that was presumably contaminated with DU. The two farming scenarios were unrealistic land uses because the additional risk to humans due to unexploded ordnance in the impact area was not figured into the risk estimate. The doses estimated with RESRAD translated to less than 1 {times} 10{sup {minus}6} detriments to about 1 {times} 10{sup {minus}3} detriments. The higher risks were associated only with the farming scenario in which drinking water was obtained on-site.

  13. Ehrlichia chaffeensis (Rickettsiales: Ehrlichieae) infection in Amblyomma americanum (Acari: Ixodidae) at Aberdeen Proving Ground, Maryland.

    Science.gov (United States)

    Stromdahl, E Y; Randolph, M P; O'Brien, J J; Gutierrez, A G

    2000-05-01

    Human monocytic ehrlichiosis (HME) is a sometimes fatal, emerging tick-borne disease caused by the bacterium Ehrlichia chaffeensis. It is frequently misdiagnosed because its symptoms mimic those of the flu. Current evidence indicates that Amblyomma americanum (L.), the lone star tick, is the major vector of HME. To determine if E. chaffeensis is present in ticks at Aberdeen Proving Ground, MD, questing A. americanum ticks were collected from 33 sites. Nucleic acid was extracted from 34 adult and 81 nymphal pools. Sequences diagnostic for E. chaffeensis from three different loci (16S rRNA, 120-kDa protein, and a variable-length polymerase chain reaction [PCR] target, or VLPT) were targeted for amplification by the PCR. Fifty-two percent of the collection sites yielded pools infected with E. chaffeensis, confirming the presence and widespread distribution of E. chaffeensis at Aberdeen Proving Ground. Analysis with the both the 120-kDa protein primers and the VLPT primers showed that genetic variance exists. A novel combination of variance for the two loci was detected in two tick pools. The pathogenic implications of genetic variation in E. chaffeensis are as yet unknown.

  14. NASA'S Space Launch System: Progress Toward the Proving Ground

    Science.gov (United States)

    Jackman, Angie; Johnson, Les

    2017-01-01

    With significant and substantial progress being accomplished toward readying the Space Launch System (SLS) rocket for its first test flight, work is already also underway on preparations for the second flight – using an upgraded version of the vehicle – and beyond. Designed to support human missions into deep space, Space Launch System (SLS), is the most powerful human-rated launch vehicle the United States has ever undertaken, and together with the Orion spacecraft will support human exploration missions into the proving ground of cislunar space and ultimately to Mars. For its first flight, SLS will deliver a near-term heavy-lift capability for the nation with its 70-metric-ton Block 1 configuration. Each element of the vehicle now has flight hardware in production in support of the initial flight of the SLS, which will propel Orion around the moon and back. For its second flight, SLS will be upgraded to the more-capable Block 1B configuration. While the Block 1 configuration is capable of delivering more than 70 metric tons to low Earth orbit, the Block 1B vehicle will increase that capability to 105 metric tons. For that flight, the new configuration introduces two major new elements to the vehicle – an Exploration Upper Stage (EUS) that will be used for both ascent and in-space propulsion, and a Universal Stage Adapter (USA) that serves as a “payload bay” for the rocket, allowing the launch of large exploration systems along with the Orion spacecraft. Already, flight hardware is being prepared for the Block 1B vehicle. Beyond the second flight, additional upgrades will be made to the vehicle. The Block 1B vehicle will also be able to launch 8.4-meter-diameter payload fairings, larger than any previously flown, and the Spacecraft Payload Integration and Evolution (SPIE) Element will oversee development and production of those fairings. Ultimately, SLS will be evolved to a Block 2 configuration, which will replace the solid rocket boosters on the Block

  15. Toxicity of sediments surrounding the Gunpowder Neck Superfund Site at Aberdeen Proving Ground, Maryland. Final report, August 1992-December 1993

    Energy Technology Data Exchange (ETDEWEB)

    Haley, M.V.; Anthony, J.S.; Chester, N.A.; Kurnas, C.W.

    1995-07-01

    From the late 1940s through the 1960s, the standard practice for disposing of toxic chemicals at Aberdeen Proving Ground, MD, was open burning. This disposal site has since been placed on the National Priority List (NPt) by U.S. Environmental Protection Agency. In the spring 1992, sediment samples were taken from waterways that surround that disposal area. Chemical analysis and sediment toxicity assays (Ampelisca abdita) were conducted. Toxicity comparison, with sediment leachate from an Adapted Toxicity Characteristic teaching Procedure (ATCLP), were made using Daphnia magna and a fluorescent bacterium Photobacterium phosphoreum in MICROTOX assays. Amphipods showed a wide range of mortality in mud as well as coarser sediments indicating substrate preference is not critical to the outcome of the assay. Toxicity results from the leachates showed the sediments were not toxic to daphnia and MICROTOX assays.

  16. Remedial investigation report for J-Field, Aberdeen Proving Ground, Maryland. Volume 3: Ecological risk assessment

    Energy Technology Data Exchange (ETDEWEB)

    Hlohowskyj, I.; Hayse, J.; Kuperman, R.; Van Lonkhuyzen, R.

    2000-02-25

    The Environmental Management Division of the U.S. Army Aberdeen Proving Ground (APG), Maryland, is conducting a remedial investigation (RI) and feasibility study (FS) of the J-Field area at APG, pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), as amended. As part of that activity, Argonne National Laboratory (ANL) conducted an ecological risk assessment (ERA) of the J-Field site. This report presents the results of that assessment.

  17. Concept of Operations for a Prospective "Proving Ground" in the Lunar Vicinity

    Science.gov (United States)

    Love, Stanley G.; Hill, James J.

    2016-01-01

    NASA is studying a "Proving Ground" near the Moon to conduct human space exploration missions in preparation for future flights to Mars. This paper describes a concept of operations ("conops") for activities in the Proving Ground, focusing on the construction and use of a mobile Cislunar Transit Habitat capable of months-long excursions within and beyond the Earth-Moon system. Key elements in the conops include the Orion spacecraft (with mission kits for docking and other specialized operations) and the Space Launch System heavy-lift rocket. Potential additions include commercial launch vehicles and logistics carriers, solar electric propulsion stages to move elements between different orbits and eventually take them on excursions to deep space, a node module with multiple docking ports, habitation and life support blocks, and international robotic and piloted lunar landers. The landers might include reusable ascent modules which could remain docked to in-space elements between lunar sorties. The architecture will include infrastructure for launch preparation, communication, mission control, and range safety. The conops describes "case studies" of notional missions chosen to guide the design of the architecture and its elements. One such mission is the delivery of a 10-ton pressurized element, co-manifested with an Orion on a Block 1B Space Launch System rocket, to the Proving Ground. With a large solar electric propulsion stage, the architecture could enable a year-long mission to land humans on a near-Earth asteroid. In the last case, after returning to near-lunar space, two of the asteroid explorers could join two crewmembers freshly arrived from Earth for a Moon landing, helping to safely quantify the risk of landing deconditioned crews on Mars. The conops also discusses aborts and contingency operations. Early return to Earth may be difficult, especially during later Proving Ground missions. While adding risk, limited-abort conditions provide needed practice

  18. SPoRT's Participation in the GOES-R Proving Ground Activity

    Science.gov (United States)

    Jedlovec, Gary; Fuell, Kevin; Smith, Matthew; Stano, Geoffrey; Molthan, Andrew

    2011-01-01

    The next generation geostationary satellite, GOES-R, will carry two new instruments with unique atmospheric and surface observing capabilities, the Advanced Baseline Imager (ABI) and the Geostationary Lightning Mapper (GLM), to study short-term weather processes. The ABI will bring enhanced multispectral observing capabilities with frequent refresh rates for regional and full disk coverage to geostationary orbit to address many existing and new forecast challenges. The GLM will, for the first time, provide the continuous monitoring of total lightning flashes over a hemispherical region from space. NOAA established the GOES-R Proving Ground activity several years ago to demonstrate the new capabilities of these instruments and to prepare forecasters for their day one use. Proving Ground partners work closely with algorithm developers and the end user community to develop and transition proxy data sets representing GOES-R observing capabilities. This close collaboration helps to maximize refine algorithms leading to the delivery of a product that effectively address a forecast challenge. The NASA Short-term Prediction Research and Transition (SPoRT) program has been a participant in the NOAA GOES-R Proving Ground activity by developing and disseminating selected GOES-R proxy products to collaborating WFOs and National Centers. Established in 2002 to demonstrate the weather and forecasting application of real-time EOS measurements, the SPoRT program has grown to be an end-to-end research to operations activity focused on the use of advanced NASA modeling and data assimilation approaches, nowcasting techniques, and unique high-resolution multispectral data from EOS satellites to improve short-term weather forecasts on a regional and local scale. Participation in the Proving Ground activities extends SPoRT s activities and taps its experience and expertise in diagnostic weather analysis, short-term weather forecasting, and the transition of research and experimental

  19. SPoRT's Participation in the GOES-R Proving Ground Activity

    Science.gov (United States)

    Jedlovec, G.; Fuell, K.; Smith, M. R.; Stano, G. T.; Molthan, A.

    2011-12-01

    The next generation geostationary satellite, GOES-R, will carry two new instruments with unique atmospheric and surface observing capabilities, the Advanced Baseline Imager (ABI) and the Geostationary Lightning Mapper (GLM), to study short-term weather processes. The ABI will bring enhanced multispectral observing capabilities with frequent refresh rates for regional and full disk coverage to geostationary orbit to address many existing and new forecast challenges. The GLM will, for the first time, provide the continuous monitoring of total lightning flashes over a hemispherical region from space. NOAA established the GOES-R Proving Ground activity several years ago to demonstrate the new capabilities of these instruments and to prepare forecasters for their day one use. Proving Ground partners work closely with algorithm developers and the end user community to develop and transition proxy data sets representing GOES-R observing capabilities. This close collaboration helps to maximize refine algorithms leading to the delivery of a product that effectively address a forecast challenge. The NASA Short-term Prediction Research and Transition (SPoRT) program has been a participant in the NOAA GOES-R Proving Ground activity by developing and disseminating selected GOES-R proxy products to collaborating WFOs and National Centers. Established in 2002 to demonstrate the weather and forecasting application of real-time EOS measurements, the SPoRT program has grown to be an end-to-end research to operations activity focused on the use of advanced NASA modeling and data assimilation approaches, nowcasting techniques, and unique high-resolution multispectral data from EOS satellites to improve short-term weather forecasts on a regional and local scale. Participation in the Proving Ground activities extends SPoRT's activities and taps its experience and expertise in diagnostic weather analysis, short-term weather forecasting, and the transition of research and experimental

  20. Satellite Proving Ground for the GOES-R Geostationary Lightning Mapper (GLM)

    Science.gov (United States)

    Goodman, Steven J.; Gurka, James; Bruning, E. C.; Blakeslee, J. R.; Rabin, Robert; Buechler, D.

    2009-01-01

    The key mission of the Satellite Proving Ground is to demonstrate new satellite observing data, products and capabilities in the operational environment to be ready on Day 1 to use the GOES-R suite of measurements. Algorithms, tools, and techniques must be tested, validated, and assessed by end users for their utility before they are finalized and incorporated into forecast operations. The GOES-R Proving Ground for the Geostationary Lightning Mapper (GLM) focuses on evaluating how the infusion of the new technology, algorithms, decision aids, or tailored products integrate with other available tools (weather radar and ground strike networks; nowcasting systems, mesoscale analysis, and numerical weather prediction models) in the hands of the forecaster responsible for issuing forecasts and warning products. Additionally, the testing concept fosters operation and development staff interactions which will improve training materials and support documentation development. Real-time proxy total lightning data from regional VHF lightning mapping arrays (LMA) in Northern Alabama, Central Oklahoma, Cape Canaveral Florida, and the Washington, DC Greater Metropolitan Area are the cornerstone for the GLM Proving Ground. The proxy data will simulate the 8 km Event, Group and Flash data that will be generated by GLM. Tailored products such as total flash density at 1-2 minute intervals will be provided for display in AWIPS-2 to select NWS forecast offices and national centers such as the Storm Prediction Center. Additional temporal / spatial combinations are being investigated in coordination with operational needs and case-study proxy data and prototype visualizations may also be generated from the NASA heritage Lightning Imaging Sensor and Optical Transient Detector data. End users will provide feedback on the utility of products in their operational environment, identify use cases and spatial/temporal scales of interest, and provide feedback to the developers for adjusted or

  1. Research Objectives for Human Missions in the Proving Ground of Cis-Lunar Space

    Science.gov (United States)

    Spann, James; Niles, Paul; Eppler, Dean; Kennedy, Kriss; Lewis, Ruthan; Sullivan, Thomas

    2016-07-01

    Introduction: This talk will introduce the preliminary findings in support of NASA's Future Capabilities Team. In support of the ongoing studies conducted by NASA's Future Capabilities Team, we are tasked with collecting re-search objectives for the Proving Ground activities. The objectives could include but are certainly not limited to: demonstrating crew well being and performance over long duration missions, characterizing lunar volatiles, Earth monitoring, near Earth object search and identification, support of a far-side radio telescope, and measuring impact of deep space environment on biological systems. Beginning in as early as 2023, crewed missions beyond low Earth orbit will be enabled by the new capabilities of the SLS and Orion vehicles. This will initiate the "Proving Ground" phase of human exploration with Mars as an ultimate destination. The primary goal of the Proving Ground is to demonstrate the capability of suitably long dura-tion spaceflight without need of continuous support from Earth, i.e. become Earth Independent. A major component of the Proving Ground phase is to conduct research activities aimed at accomplishing major objectives selected from a wide variety of disciplines including but not limited to: Astronomy, Heliophysics, Fun-damental Physics, Planetary Science, Earth Science, Human Systems, Fundamental Space Biology, Microgravity, and In Situ Resource Utilization. Mapping and prioritizing the most important objectives from these disciplines will provide a strong foundation for establishing the architecture to be utilized in the Proving Ground. Possible Architectures: Activities and objectives will be accomplished during the Proving Ground phase using a deep space habitat. This habitat will potentially be accompanied by a power/propulsion bus capable of moving the habitat to accomplish different objectives within cis-lunar space. This architecture can also potentially support stag-ing of robotic and tele-robotic assets as well as

  2. Hydrogeologic data for the Canal Creek area, Aberdeen Proving Ground, Maryland, April 1986-March 1988

    Science.gov (United States)

    Oliveros, J.P.; Gernhardt, Patrice

    1989-01-01

    This report is a compilation of hydrologic and geologic data collected for the period April 1986 through March 1988 for the Canal Creek area of Aberdeen Proving Ground, Maryland. Geologic data include lithologic logs for 73 sites and geophysical logs for 71 sites. Hydrologic data consist of hydrographs and synoptic water level measurements. The hydrographs were taken from eight wells that were equipped with continuous water level recorders, and the synoptic water-level measurements were made four times during the study. Well-construction data also are included for 149 observation wells. (USGS)

  3. Initial building investigations at Aberdeen Proving Ground, Maryland: Objectives and methodology

    Energy Technology Data Exchange (ETDEWEB)

    Brubaker, K.L.; Dougherty, J.M.; McGinnis, L.D.

    1994-12-01

    As part of an environmental-contamination source-definition program at Aberdeen Proving Ground, detailed internal and external inspections of 23 potentially contaminated buildings are being conducted to describe and characterize the state of each building as it currently exists and to identify areas potentially contaminated with toxic or other hazardous substances. In addition, a detailed geophysical investigation is being conducted in the vicinity of each target building to locate and identify subsurface structures, associated with former building operations, that are potential sources of contamination. This report describes the objectives of the initial building inspections, including the geophysical investigations, and discusses the methodology that has been developed to achieve these objectives.

  4. Hydrogeologic setting, hydraulic properties, and ground-water flow at the O-Field area of Aberdeen Proving Ground, Maryland

    Science.gov (United States)

    Banks, W.S.; Smith, B.S.; Donnelly, C.A.

    1996-01-01

    The U.S. Army disposed chemical agents, laboratory materials, and unexploded ordnance at O-Field in the Edgewood area of Aberdeen Proving Ground, Maryland, from before World War II until at least the 1950's. Soil, ground water, surface water,and wetland sediments in the O-Field area were contaminated from the disposal activity. A ground-water-flow model of the O-Field area was constructed by the U.S. Geological Survey (USGS) in 1989 to simulate flow in the central and southern part of the Gunpowder Neck. The USGS began an additional study of the contamination in the O-Field area in cooperation with the U.S. Army in 1990 to (1) further define the hydrogeologic framework of the O-Field area, (2) characterize the hydraulic properties of the aquifers and confining units, and (3) define ground-water flow paths at O-Field based on the current data and simulations of ground-water flow. A water-table aquifer, an upper confining unit, and an upper confined aquifer comprise the shallow ground-water aquifer system of the O-Field area. A lower confining unit, through which ground-water movement is negligible, is considered a lower boundary to the shallow aquifer system. These units are all part of the Pleistocene Talbot Formation. The model developed in the previous study was redesigned using the data collected during this study and emphasized New O-Field. The current steady-state model was calibrated to water levels of June 1993. The rate of ground-water flow calculated by the model was approximately 0.48 feet per day (ft/d) and the rate determined from chlorofluorocarbon dates was approximately 0.39 ft/d.

  5. Ecological survey of M-Field, Edgewood Area Aberdeen Proving Ground, Maryland

    Energy Technology Data Exchange (ETDEWEB)

    Downs, J.L.; Eberhardt, L.E.; Fitzner, R.E.; Rogers, L.E.

    1991-12-01

    An ecological survey was conducted on M-Field, at the Edgewood Area, Aberdeen Proving Ground, Maryland. M-Field is used routinely to test army smokes and obscurants, including brass flakes, carbon fibers, and fog oils. The field has been used for testing purposes for the past 40 years, but little documented history is available. Under current environmental regulations, the test field must be assessed periodically to document the presence or potential use of the area by threatened and endangered species. The M-Field area is approximately 370 acres and is part of the US Army`s Edgewood Area at Aberdeen Proving Ground in Harford County, Maryland. The grass-covered field is primarily lowlands with elevations from about 1.0 to 8 m above sea level, and several buildings and structures are present on the field. The ecological assessment of M-Field was conducted in three stages, beginning with a preliminary site visit in May to assess sampling requirements. Two field site visits were made June 3--7, and August 12--15, 1991, to identify the biota existing on the site. Data were gathered on vegetation, small mammals, invertebrates, birds, large mammals, amphibians, and reptiles.

  6. Ecological survey of M-Field, Edgewood Area Aberdeen Proving Ground, Maryland

    Energy Technology Data Exchange (ETDEWEB)

    Downs, J.L.; Eberhardt, L.E.; Fitzner, R.E.; Rogers, L.E.

    1991-12-01

    An ecological survey was conducted on M-Field, at the Edgewood Area, Aberdeen Proving Ground, Maryland. M-Field is used routinely to test army smokes and obscurants, including brass flakes, carbon fibers, and fog oils. The field has been used for testing purposes for the past 40 years, but little documented history is available. Under current environmental regulations, the test field must be assessed periodically to document the presence or potential use of the area by threatened and endangered species. The M-Field area is approximately 370 acres and is part of the US Army's Edgewood Area at Aberdeen Proving Ground in Harford County, Maryland. The grass-covered field is primarily lowlands with elevations from about 1.0 to 8 m above sea level, and several buildings and structures are present on the field. The ecological assessment of M-Field was conducted in three stages, beginning with a preliminary site visit in May to assess sampling requirements. Two field site visits were made June 3--7, and August 12--15, 1991, to identify the biota existing on the site. Data were gathered on vegetation, small mammals, invertebrates, birds, large mammals, amphibians, and reptiles.

  7. Ground-water flow and the potential effects of remediation at Graces Quarters, Aberdeen Proving Ground, Maryland

    Science.gov (United States)

    Tenbus, F.J.; Fleck, W.B.

    1996-01-01

    Ground water in the east-central part of Graces Quarters, a former open-air chemical-agent test facility at Aberdeen Proving Ground, Maryland, is contaminated with chlorinated volatile organic compounds. The U.S. Geological Survey's finite- difference model was used to help understand ground-water flow and simulate the effects of alternative remedial actions to clean up the ground water. Scenarios to simulate unstressed conditions and three extraction well con- figurations were used to compare alternative remedial actions on the contaminant plume. The scenarios indicate that contaminants could migrate from their present location to wetland areas within 10 years under unstressed conditions. Pumping 7 gal/min (gallons per minute) from one well upgradient of the plume will not result in containment or removal of the highest contaminant concentrations. Pumping 7 gal/min from three wells along the central axis of the plume should result in containment and removal of dissolved contami- nants, as should pumping 7 gal/min from three wells at the leading edge of the plume while injecting 7 gal/min back into an upgradient well.

  8. Natural attenuation of chlorinated volatile organic compounds in a freshwater tidal wetland, Aberdeen Proving Ground, Maryland

    Science.gov (United States)

    Lorah, Michelle M.; Olsen, Lisa D.; Smith, Barrett L.; Johnson, Mark A.; Fleck, William B.

    1997-01-01

    Ground-water contaminant plumes that are flowing toward or currently discharging to wetland areas present unique remediation problems because of the hydrologic connections between ground water and surface water and the sensitive habitats in wetlands. Because wetlands typically have a large diversity of microorganisms and redox conditions that could enhance biodegradation, they are ideal environments for natural attenuation of organic contaminants, which is a treatment method that would leave the ecosystem largely undisturbed and be cost effective. During 1992-97, the U.S. Geological Survey investigated the natural attenuation of chlorinated volatile organic compounds (VOC's) in a contaminant plume that discharges from a sand aquifer to a freshwater tidal wetland along the West Branch Canal Creek at Aberdeen Proving Ground, Maryland. Characterization of the hydrogeology and geochemistry along flowpaths in the wetland area and determination of the occurrence and rates of biodegradation and sorption show that natural attenuation could be a feasible remediation method for the contaminant plume that extends along the West Branch Canal Creek.

  9. An Overview of NASA SPoRT GOES-R JPSS Proving Ground Testbed Activities

    Science.gov (United States)

    Berndt, Emily; Stano, Geoffrey; Fuell, Kevin; Leroy, Anita; Mcgrath, Kevin; Molthan, Andrew; Schultz, Lori; Smith, Matthew; White, Kris; Schultz, Christopher; hide

    2017-01-01

    The Short-term Prediction Research and Transition (SPoRT) Center is funded by NASA's Earth Science Division and NOAA's JPSS and GOES-R Proving Grounds to transition satellite products and capabilities to the NWS to improve short term (0-48 hr) forecasts on a regional and local scale. SPoRT currently collaborates with 30+ NWS WFOs (at least one in each NWS region) and 5 National Centers/Testbeds. SPoRT matches user-identified forecast challenges to specific products, providing access to these data in AWIPS through new plug-in development, and generating applications-based training to use the products for their needs (R20). Upon transition, SPoRT collaborates with the user to assess the product impact in a real-world environment for feedback to product developers (O2R) and to benefit their peers.

  10. NOAA's Joint Polar Satellite System's Proving Ground and Risk Reduction Program - Bringing New Capabilities to Operations!

    Science.gov (United States)

    Sjoberg, B.

    2015-12-01

    This presentation will focus on the NOAA Joint Polar Satellite System (JPSS) Program's Proving Ground and Risk Reduction (PGRR) initiative and how it has prepared NOAA users to effectively utilize new polar-orbiting capabilities. The PGRR Program was established in 2012, following the launch of the Suomi National Polar Partnership (SNPP) satellite. Two sets of PGRR Projects have been established grouped together in thirteen different initiatives. Details about how these projects have been continually tailored through the years to meet user requirements, will be highlighted. The presenter will focus on how the success of the first set of PGRR projects have been used to evaluate a follow-on set of projects and focus on exactly what the JPSS user community needs to meet their mission requirements. Details on the Dec 2014 PGRR Call-for-Proposals and the projects selected for funding will be discussed.

  11. Design and analysis of a natural-gradient ground-water tracer test in a freshwater tidal wetland, West Branch Canal Creek, Aberdeen Proving Ground, Maryland

    Science.gov (United States)

    Olsen, Lisa D.; Tenbus, Frederick J.

    2005-01-01

    each, from July 1998 through September 1999, to assess background conditions and monitor tracer movement. During the test, 644 samples were analyzed for fluorescein, 617 samples were analyzed for bromide with an ion-selective electrode, 213 samples were analyzed for bromide with colorimetric methods, and 603 samples were analyzed for sulfur hexafluoride, including samples collected prior to tracer injection to determine background concentrations. Additional samples were analyzed for volatile organic compounds (96 samples) and methane (37 samples) to determine the distribution of these contaminants and the extent of methanogenic conditions within the tracer array; however, these data were not used for the analysis of the test. During the tracer test, the fluorescein dye, bromide, and sulfur hexafluoride were transported predominantly in the upward direction, although all three tracers also moved outward in all directions from the injection point, and it is likely that some tracer mass moved beyond the lateral edges of the array. An analysis of the tracer-test data was performed through the use of breakthrough curves and isoconcentration contour plots. Results show that movement of the fluorescein dye, a non-conservative tracer, was retarded compared to the other two tracers, likely as a result of sorption onto the wetland sediments. Suspected loss of tracer mass along the lateral edges of the array prevented a straightforward quantitative analysis of tracer transport and ground-water velocity from the bromide and sulfur-hexafluoride data. In addition, the initial density of the bromide/sulfur hexafluoride solution (calculated to be 1.097 grams per milli2 Ground-Water Tracer Test, West Branch Canal Creek, Aberdeen Proving Ground, MD liter) could have caused the solution to sink below the injection point before undergoing dilution and moving back up into the array. For these reasons, the data analysis in this report was performed largely through qualitative method

  12. Optimization of ground-water withdrawal at the old O-Field area, Aberdeen Proving Ground, Maryland

    Science.gov (United States)

    Banks, William S.L.; Dillow, Jonathan J.A.

    2001-01-01

    The U.S. Army disposed of chemical agents, laboratory materials, and unexploded ordnance at the Old O-Field landfill at Aberdeen Proving Ground, Maryland, beginning prior to World War II and continuing until at least the 1950?s. Soil, ground water, surface water, and wetland sediments in the Old O-Field area were contaminated by the disposal of these materials. The site is in the Atlantic Coastal Plain, and is characterized by a complex series of Pleistocene and Holocene sediments formed in various fluvial, estuarine, and marine-marginal hydrogeologic environments. A previously constructed transient finite-difference ground-water-flow model was used to simulate ground-water flow and the effects of a pump-and-treat remediation system designed to prevent contaminated ground water from flowing into Watson Creek (a tidal estuary and a tributary to the Gunpowder River). The remediation system consists of 14 extraction wells located between the Old O-Field landfill and Watson Creek.Linear programming techniques were applied to the results of the flow-model simulations to identify optimal pumping strategies for the remediation system. The optimal management objective is to minimize total withdrawal from the water-table aquifer, while adhering to the following constraints: (1) ground-water flow from the landfill should be prevented from reaching Watson Creek, (2) no extraction pump should be operated at a rate that exceeds its capacity, and (3) no extraction pump should be operated at a rate below its minimum capacity, the minimum rate at which an Old O-Field pump can function. Water withdrawal is minimized by varying the rate and frequency of pumping at each of the 14 extraction wells over time. This minimizes the costs of both pumping and water treatment, thus providing the least-cost remediation alternative while simultaneously meeting all operating constraints.The optimal strategy identified using this objective and constraint set involved operating 13 of the 14

  13. Ground-water and surface-water quality data for the West Branch Canal Creek area, Aberdeen Proving Ground, Maryland

    Science.gov (United States)

    Spencer, Tracey A.; Phelan, Daniel J.; Olsen, Lisa D.; Lorah, Michelle M.

    2001-01-01

    This report presents ground-water and surface-water quality data from samples collected by the U.S. Geological Survey from November 1999 through May 2001 at West Branch Canal Creek, Aberdeen Proving Ground, Maryland. The report also provides a description of the sampling and analytical methods that were used to collect and analyze the samples, and includes an evaluation of the quality-assurance data. The ground-water sampling network included two 4-inch wells, two 2-inch wells, sixteen 1-inch piezometers, one hundred thirteen 0.75-inch piezometers, two 0.25-inch flexible-tubing piezo-meters, twenty-seven 0.25-inch piezometers, and forty-two multi-level monitoring system depths at six sites. Ground-water profiler samples were collected from nine sites at 34 depths. In addition, passive-diffusion-bag samplers were deployed at four sites, and porous-membrane sampling devices were installed in the upper sediment at five sites. Surface-water samples were collected from 20 sites. Samples were collected from wells and 0.75-inch piezometers for measurement of field parameters and reduction-oxidation constituents, and analysis of inorganic and organic constituents, during three sampling events in March?April and June?August 2000, and May 2001. Surface-water samples were collected from November 1999 through September 2000 during five sampling events for analysis of organic constituents. Ground-water profiler samples were collected in April?May 2000, and analyzed for field measure-ments, reduction-oxidation constituents, and inorganic constituents and organic constituents. Passive-diffusion-bag samplers were installed in September 2000, and samples were analyzed for organic constituents. Multi-level monitoring system samples were collected and analyzed for field measurements and reduction-oxidation con-stituents, inorganic constituents, and organic con-stituents in March?April and June?August 2000. Field measurements and organic constituents were collected from 0.25-inch

  14. GOES-R Proving Ground Activities at the NASA Short-Term Prediction Research and Transition (SPoRT) Center

    Science.gov (United States)

    Molthan, Andrew

    2011-01-01

    SPoRT is actively involved in GOES-R Proving Ground activities in a number of ways: (1) Applying the paradigm of product development, user training, and interaction to foster interaction with end users at NOAA forecast offices national centers. (2) Providing unique capabilities in collaboration with other GOES-R Proving Ground partners (a) Hybrid GOES-MODIS imagery (b) Pseudo-GLM via regional lightning mapping arrays (c) Developing new RGB imagery from EUMETSAT guidelines

  15. Air monitoring for volatile organic compounds at the Pilot Plant Complex, Aberdeen Proving Ground, Maryland

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, J.F.; O`Neill, H.J.; Raphaelian, L.A.; Tomczyk, N.A.; Sytsma, L.F.; Cohut, V.J.; Cobo, H.A.; O`Reilly, D.P.; Zimmerman, R.E.

    1995-03-01

    The US Army`s Aberdeen Proving Ground has been a test site for a variety of munitions, including chemical warfare agents (CWA). The Pilot Plant Complex (PPC) at Aberdeen was the site of development, manufacture, storage, and disposal of CWA. Deterioration of the buildings and violations of environmental laws led to closure of the complex in 1986. Since that time, all equipment, piping, and conduit in the buildings have been removed. The buildings have been declared free of surface CWA contamination as a result of air sampling using the military system. However, no air sampling has been done to determine if other hazardous volatile organic compounds are present in the PPC, although a wide range of toxic and/or hazardous materials other than CWA was used in the PPC. The assumption has been that the air in the PPC is not hazardous. The purpose of this air-monitoring study was to screen the indoor air in the PPC to confirm the assumption that the air does not contain volatile organic contaminants at levels that would endanger persons in the buildings. A secondary purpose was to identify any potential sources of volatile organic contaminants that need to be monitored in subsequent sampling efforts.

  16. An Evaluation of Activated Bismuth Isotopes in Environmental Samples From the Former Western Pacific Proving Grounds

    Energy Technology Data Exchange (ETDEWEB)

    Robison, W.L.; Brunk, J.A.; Jokela, T.A.

    2000-03-21

    {sup 207}Bi (t{sub 1/2}=32.2 y) was generated by activation of weapons material during a few ''clean'' nuclear tests at the U.S. Western Pacific Proving Grounds of Enewetak and Bikini Atolls. The radionuclides first appeared in the Enewetak environment during 1958 and in the environment of Bikini during 1956. Crater sediments from Bikini with high levels of {sup 207}Bi were analyzed by gamma spectrometry in an attempt to determine the relative concentrations of {sup 208}Bi (t{sup 1/2} = 3.68 x 10{sup 5} y). The bismuth isotopes were probably generated during the ''clean'', 9.3 Mt Poplar test held on 7/12/58. The atom ratio of {sup 208}Bi to {sup 207}Bi (R value) ranges from {approx}12 to over 200 in sections of core sediments from the largest nuclear crater at Bikini atoll. The presence of bismuth in the device is suggested to account for R values in excess of 10.

  17. Hydrogeologic and chemical data for the O-Field area, Aberdeen Proving Ground, Maryland

    Science.gov (United States)

    Nemoff, P.R.; Vroblesky, D.A.

    1989-01-01

    O-Field, located at the Edgewood area of Aberdeen Proving Ground , Maryland, was periodically used for disposal of munitions, waste chemicals, and chemical-warfare agents from World War II through the 1950' s. This report includes various physical, geologic, chemical, and hydrologic data obtained from well-core, groundwater, surface water, and bottom-sediment sampling sites at and near the O-Field disposal area. The data are presented in tables and hydrographs. Three site-location maps are also included. Well-core data include lithologic logs for 11 well- cluster sites, grain-size distributions, various chemical characteristics, and confining unit characteristics. Groundwater data include groundwater chemistry, method blanks for volatile organic carbon, available data on volatile and base/neutral organics, and compilation of corresponding method blanks, chemical-warfare agents, explosive-related products, radionuclides, herbicides, and groundwater levels. Surface-water data include field-measured characteristics; concentrations of various inorganic constituents including arsenic; selected organic constituents with method blanks; detection limits of organics; and a compilation of information on corresponding acids, volatiles, and semivolatiles. Bottom- sediment data include inorganic properties and constituents; organic chemistry; detection limits for organic chemicals; a compilation of information on acids, volatiles, and semivolatiles; and method blanks corresponding to acids, volatiles, and semivolatiles. A set of 15 water- level hydrographs for the period March 1986 through September 1987 also is included in the report. (USGS)

  18. Hydrogeology and soil gas at J-Field, Aberdeen Proving Ground, Maryland

    Science.gov (United States)

    Hughes, W.B.

    1993-01-01

    Disposal of chemical warfare agents, munitions, and industrial chemicals in J-Field, Aberdeen Proving Ground, Maryland, has contaminated soil, groundwater and surface water. Seven exploratory borings and 38 observation wells were drilled to define the hydrogeologic framework at J-Field and to determine the type, extent, and movement of contaminants. The geologic units beneath J-Field consist of Coastal Plain sediments of the Cretaceous Patapsco Formation and Pleistocene Talbot Formation. The Patapsco Formation contains several laterally discontinuous aquifers and confining units. The Pleistocene deposits were divided into 3 hydrogeologic units--a surficial aquifer, a confining unit, and a confined aquifer. Water in the surficial aquifer flows laterally from topographically high areas to discharge areas in marshes and streams, and vertically to the underlying confined aquifer. In offshore areas, water flows from the deeper confined aquifers upward toward discharge areas in the Gunpowder River and Chesapeake Bay. Analyses of soil-gas samples showed high relative-flux values of chlorinated solvents, phthalates, and hydrocarbons at the toxic-materials disposal area, white-phosphorus disposal area, and riot-control-agent disposal area. The highest flux values were located downgradient of the toxic materials and white phosphorus disposal areas, indicating that groundwater contaminants are moving from source areas beneath the disposal pits toward discharge points in the marshes and estuaries. Elevated relative-flux values were measured upgradient and downgradient of the riot-control agent disposal area, and possibly result from soil and (or) groundwater contamination.

  19. Contamination source review for Building E2370, Edgewood Area, Aberdeen Proving Ground, Maryland

    Energy Technology Data Exchange (ETDEWEB)

    O`Reilly, D.P.; Glennon, M.A.; Draugelis, A.K.; Rueda, J.; Zimmerman, R.E.

    1995-09-01

    The US Army Aberdeen Proving Ground (APG) commissioned Argonne National Laboratory (ANL) to conduct a contamination source review to identify and define areas of toxic or hazardous contaminants and to assess the physical condition and accessibility of APG buildings. The information obtained from this review may be used to assist the US Army in planning for the future use or disposition of the buildings. The contamination source review consisted of the following tasks: historical records search, physical inspection, photographic documentation, and geophysical investigation. This report provides the results of the contamination source review for Building E2370. Many of the APG facilities constructed between 1917 and the 1960s are no longer used because of obsolescence and their poor state of repair. Because many of these buildings were used for research, development, testing, and/or pilot-scale production of chemical warfare agents and other military substances, the potential exists for portions of the buildings to be contaminated with these substances, their degradation products, and other laboratory or industrial chemicals. These buildings and associated structures or appurtenances may contribute to environmental concerns at APG.

  20. Contamination source review for Building E1489, Edgewood Area, Aberdeen Proving Ground, Maryland

    Energy Technology Data Exchange (ETDEWEB)

    Billmark, K.A.; Hayes, D.C.; Draugelis, A.K. [and others

    1995-09-01

    This report was prepared by Argonne National Laboratory (ANL) to document the results of a contamination source review of Building E1489 at the Aberdeen Proving Ground (APG) in Maryland. This report may be used to assist the U.S. Army-in planning for the future use or disposition of this building. The review included a historical records search, physical inspection, photographic documentation, and geophysical investigation. The field investigations were performed in 1994-1995. Building E1489 located in J-Field on the Gunpowder Peninsula in APG`s Edgewood Area housed a power generator that supplied electricity to a nearby observation tower. Building E1489 and the generator were abandoned in 1974, demolished by APG personnel and removed from real estate records. A physical inspection and photographic documentation of Building E1489 were completed by ANL staff during November 1994. In 1994, ANL staff conducted geophysical surveys in the immediate vicinity of Building E1489 by using several nonintrusive methods. Survey results suggest the presence of some underground objects near Building E1489, but they do not provide conclusive evidence of the source of geophysical anomalies observed during the survey. No air monitoring was conducted at the site, and no information on underground storage tanks associated with Building E1489 was available.

  1. Contamination source review for Building E3180, Edgewood Area, Aberdeen Proving Ground, Maryland

    Energy Technology Data Exchange (ETDEWEB)

    Zellmer, S.D.; Smits, M.P.; Rueda, J.; Zimmerman, R.E.

    1995-09-01

    This report was prepared by Argonne National Laboratory (ANL) to document the results of a contamination source review of Building E3180 at the Aberdeen Proving Ground (APG) in Maryland. The report may be used to assist the US Army in planning for the future use or disposition of this building. The review included a historical records search, physical inspection, photographic documentation, geophysical investigation, collection of air samples, and review of available records regarding underground storage tanks associated with Building E3180. The field investigations were performed by ANL during 1994. Building,E3180 (current APG designation) is located near the eastern end of Kings Creek Road, north of Kings Creek, and about 0.5 miles east of the airstrip within APG`s Edgewood Area. The building was constructed in 1944 as a facsimile of a Japanese pillbox and used for the development of flame weapons systems until 1957 (EAI Corporation 1989). The building was not used from 1957 until 1965, when it was converted and used as a flame and incendiary laboratory. During the 1970s, the building was converted to a machine (metal) shop and used for that purpose until 1988.

  2. Contamination source review for Building E6891, Edgewood Area, Aberdeen Proving Ground, Maryland

    Energy Technology Data Exchange (ETDEWEB)

    Zellmer, S.D.; Draugelis, A.K.; Rueda, J.; Zimmerman, R.E.

    1995-09-01

    The US Army Aberdeen Proving Ground (APG) commissioned Argonne National Laboratory (ANL) to conduct a contamination source review to identify and define areas of toxic or hazardous contaminants and to assess the physical condition and accessibility of various APG buildings. This report provides the results of the contamination source review for Building E6891. The information obtained from this review may be used to assist the US Army in planning for the future use or disposition of the buildings. The contamination source review consisted of the following tasks: historical records search, physical inspection, photographic documentation, geophysical investigation, and collection of air samples. This building is part of the Lauderick Creek Concrete Slab Test Site, located in the Lauderick Creek Area in the Edgewood Area. Many of the APG facilities constructed between 1917 and the 1960s are no longer used because of obsolescence and their poor state of repair. Because many of these buildings were used for research, development, testing, and/or pilot-scale production of chemical warfare agents and other military substances the potential exists` for portions of the buildings to be contaminated with these substances, their degradation products, and other laboratory or industrial chemicals. These buildings and associated structures or appurtenances may contribute to environmental concerns at APG.

  3. Contamination source review for Building E3162, Edgewood Area, Aberdeen Proving Ground, Maryland

    Energy Technology Data Exchange (ETDEWEB)

    Miller, G.A.; Draugelis, A.K.; Rueda, J.; Zimmerman, R.E.

    1995-09-01

    This report was prepared by Argonne National Laboratory (ANL) to document the results of a contamination source review for Building E3162 at the Aberdeen Proving Ground (APG) in Maryland. The report may be used to assist the US Army in planning for the future use or disposition of this building. The review included a historical records search, physical inspection, photographic documentation, geophysical investigation, and collection of air samples. The field investigations were performed by ANL during 1994 and 1995. Building E3162 (APG designation) is part of the Medical Research Laboratories Building E3160 Complex. This research laboratory complex is located west of Kings Creek, east of the airfield and Ricketts Point Road, and south of Kings Creek Road in the Edgewood Area of APG. The original structures in the E3160 Complex were constructed during World War 2. The complex was originally used as a medical research laboratory. Much of the research involved wound assessment involving chemical warfare agents. Building E3162 was used as a holding and study area for animals involved in non-agent burns. The building was constructed in 1952, placed on inactive status in 1983, and remains unoccupied. Analytical results from these air samples revealed no distinguishable difference in hydrocarbon and chlorinated solvent levels between the two background samples and the sample taken inside Building E3162.

  4. Review of analytical results from the proposed agent disposal facility site, Aberdeen Proving Ground

    Energy Technology Data Exchange (ETDEWEB)

    Brubaker, K.L.; Reed, L.L.; Myers, S.W.; Shepard, L.T.; Sydelko, T.G.

    1997-09-01

    Argonne National Laboratory reviewed the analytical results from 57 composite soil samples collected in the Bush River area of Aberdeen Proving Ground, Maryland. A suite of 16 analytical tests involving 11 different SW-846 methods was used to detect a wide range of organic and inorganic contaminants. One method (BTEX) was considered redundant, and two {open_quotes}single-number{close_quotes} methods (TPH and TOX) were found to lack the required specificity to yield unambiguous results, especially in a preliminary investigation. Volatile analytes detected at the site include 1, 1,2,2-tetrachloroethane, trichloroethylene, and tetrachloroethylene, all of which probably represent residual site contamination from past activities. Other volatile analytes detected include toluene, tridecane, methylene chloride, and trichlorofluoromethane. These compounds are probably not associated with site contamination but likely represent cross-contamination or, in the case of tridecane, a naturally occurring material. Semivolatile analytes detected include three different phthalates and low part-per-billion amounts of the pesticide DDT and its degradation product DDE. The pesticide could represent residual site contamination from past activities, and the phthalates are likely due, in part, to cross-contamination during sample handling. A number of high-molecular-weight hydrocarbons and hydrocarbon derivatives were detected and were probably naturally occurring compounds. 4 refs., 1 fig., 8 tabs.

  5. Remedial investigation report for J-Field, Aberdeen Proving Ground, Maryland. Volume 1: Remedial investigation results

    Energy Technology Data Exchange (ETDEWEB)

    Yuen, C. R.; Martino, L. E.; Biang, R. P.; Chang, Y. S.; Dolak, D.; Van Lonkhuyzen, R. A.; Patton, T. L.; Prasad, S.; Quinn, J.; Rosenblatt, D. H.; Vercellone, J.; Wang, Y. Y.

    2000-03-14

    This report presents the results of the remedial investigation (RI) conducted at J-Field in the Edgewood Area of Aberdeen Proving Ground (APG), a U.S. Army installation located in Harford County, Maryland. Since 1917, activities in the Edgewood Area have included the development, manufacture, and testing of chemical agents and munitions and the subsequent destruction of these materials at J-Field by open burning and open detonation. These activities have raised concerns about environmental contamination at J-Field. This RI was conducted by the Environmental Conservation and Restoration Division, Directorate of Safety, Health and Environmental Division of APG, pursuant to requirements outlined under the Comprehensive Environmental Response, Compensation, and Liability Act, as amended (CERCLA). The RI was accomplished according to the procedures developed by the U.S. Environmental Protection Agency (EPA 1988). The RI provides a comprehensive evaluation of the site conditions, nature of contaminants present, extent of contamination, potential release mechanisms and migration pathways, affected populations, and risks to human health and the environment. This information will be used as the basis for the design and implementation of remedial actions to be performed during the remedial action phase, which will follow the feasibility study (FS) for J-Field.

  6. Contamination of ground water, surface water, and soil, and evaluation of selected ground-water pumping alternatives in the Canal Creek area of Aberdeen Proving Ground, Maryland

    Science.gov (United States)

    Lorah, Michelle M.; Clark, Jeffrey S.

    1996-01-01

    Chemical manufacturing, munitions filling, and other military-support activities have resulted in the contamination of ground water, surface water, and soil in the Canal Creek area of Aberdeen Proving Ground, Maryland. Chlorinated volatile organic compounds, including 1,1,2,2-tetrachloroethane and trichloroethylene, are widespread ground-water contaminants in two aquifers that are composed of unconsolidated sand and gravel. Distribution and fate of chlorinated organic compounds in the ground water has been affected by the movement and dissolution of solvents in their dense immiscible phase and by microbial degradation under anaerobic conditions. Detection of volatile organic contaminants in adjacent surface water indicates that shallow contaminated ground water discharges to surface water. Semivolatile organic compounds, especially polycyclic aromatic hydrocarbons, are the most prevalent organic contaminants in soils. Various trace elements, such as arsenic, cadmium, lead, and zinc, were found in elevated concentrations in ground water, surface water, and soil. Simulations with a ground-water-flow model and particle tracker postprocessor show that, without remedial pumpage, the contaminants will eventually migrate to Canal Creek and Gunpowder River. Simulations indicate that remedial pumpage of 2.0 million gallons per day from existing wells is needed to capture all particles originating in the contaminant plumes. Simulated pumpage from offsite wells screened in a lower confined aquifer does not affect the flow of contaminated ground water in the Canal Creek area.

  7. Simulation of ground-water flow and transport of chlorinated hydrocarbons at Graces Quarters, Aberdeen Proving Ground, Maryland

    Science.gov (United States)

    Tenbus, Frederick J.; Fleck, William B.

    2001-01-01

    Military activity at Graces Quarters, a former open-air chemical-agent facility at Aberdeen Proving Ground, Maryland, has resulted in ground-water contamination by chlorinated hydrocarbons. As part of a ground-water remediation feasibility study, a three-dimensional model was constructed to simulate transport of four chlorinated hydrocarbons (1,1,2,2-tetrachloroethane, trichloroethene, carbon tetrachloride, and chloroform) that are components of a contaminant plume in the surficial and middle aquifers underlying the east-central part of Graces Quarters. The model was calibrated to steady-state hydraulic head at 58 observation wells and to the concentration of 1,1,2,2-tetrachloroethane in 58 observation wells and 101direct-push probe samples from the mid-1990s. Simulations using the same basic model with minor adjustments were then run for each of the other plume constituents. The error statistics between the simulated and measured concentrations of each of the constituents compared favorably to the error statisticst,1,2,2-tetrachloroethane calibration. Model simulations were used in conjunction with contaminant concentration data to examine the sources and degradation of the plume constituents. It was determined from this that mixed contaminant sources with no ambient degradation was the best approach for simulating multi-species solute transport at the site. Forward simulations were run to show potential solute transport 30 years and 100 years into the future with and without source removal. Although forward simulations are subject to uncertainty, they can be useful for illustrating various aspects of the conceptual model and its implementation. The forward simulation with no source removal indicates that contaminants would spread throughout various parts of the surficial and middle aquifers, with the100-year simulation showing potential discharge areas in either the marshes at the end of the Graces Quarters peninsula or just offshore in the estuaries. The

  8. Work plan for conducting an ecological risk assessment at J-Field, Aberdeen Proving Ground, Maryland

    Energy Technology Data Exchange (ETDEWEB)

    Hlohowskyj, I.; Hayse, J.; Kuperman, R. [Argonne National Lab., IL (United States). Environmental Assessment Div.] [and others

    1995-03-01

    The Environmental Management Division of Aberdeen Proving Ground (APG), Maryland, is conducting a remedial investigation and feasibility study (RI/FS) of the J-Field area at APG pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), as amended. J-Field is within the Edgewood Area of APG in Harford County, Maryland, and activities at the Edgewood Area since World War II have included the development, manufacture, testing, and destruction of chemical agents and munitions. The J-Field site was used to destroy chemical agents and munitions by open burning and open detonation. This work plan presents the approach proposed to conduct an ecological risk assessment (ERA) as part of the RI/FS program at J-Field. This work plan identifies the locations and types of field studies proposed for each area of concern (AOC), the laboratory studies proposed to evaluate toxicity of media, and the methodology to be used in estimating doses to ecological receptors and discusses the approach that will be used to estimate and evaluate ecological risks at J-Field. Eight AOCs have been identified at J-Field, and the proposed ERA is designed to evaluate the potential for adverse impacts to ecological receptors from contaminated media at each AOC, as well as over the entire J-Field site. The proposed ERA approach consists of three major phases, incorporating field and laboratory studies as well as modeling. Phase 1 includes biotic surveys of the aquatic and terrestrial habitats, biological tissue sampling and analysis, and media toxicity testing at each AOC and appropriate reference locations. Phase 2 includes definitive toxicity testing of media from areas of known or suspected contamination or of media for which the Phase 1 results indicate toxicity or adverse ecological effects. In Phase 3, the uptake models initially developed in Phase 2 will be finalized, and contaminant dose to each receptor from all complete pathways will be estimated.

  9. A Prochlorococcus proving ground for constraint-based metabolic modeling and multi-`omics data integration

    Science.gov (United States)

    Casey, J.; Ji, B.; Shaoie, S.; Mardinoglu, A.; Sarathi Sen, P.; Jahn, O.; Reda, K.; Leigh, J.; Follows, M. J.; Nielsen, J.; Karl, D. M.

    2016-02-01

    Representatives of the oligotrophic marine cyanobacterium Prochlorococcus marinus are the smallest free-living photosynthetic organisms, both in terms of physical size and genome size, yet are the most abundant photoautotrophic microbes in the oceans and profoundly influence global biogeochemical cycles. Physiological and regulatory control of nutrient and light stress has been observed in MED4 in culture and in its closely related `ecotype' eMED4 in the field, however its metabolism has not been investigated in detail. We present a genome-scale metabolic network reconstruction of the high-light adapted axenic strain MED4ax ("iJCMED4") for the quantitative analysis of a range of its metabolic phenotypes. The resulting structure is a proving ground for the incorporation of enzyme kinetics, biochemical and elemental compositional data, transcriptomic, proteomic, metabolomic, and fluxomic datasets which can be implemented within a constraint-based metabolic modeling environment. The iJCMED4 stoichiometric model consists of 523 metabolic genes encoding 787 reactions with 673 unique metabolites distributed in 5 sub-cellular compartments and is mass, charge, and thermodynamically balanced. Several variants of flux balance analysis were used to simulate growth and metabolic fluxes over the diel cycle, under various stress conditions (e.g., nitrogen, phosphorus, light), and within the framework of a global biogeochemical model (DARWIN). Model simulations accurately predicted growth rates in culture under a variety of defined medium compositions and there was close agreement of photosynthetic performance, biomass and energy yields and efficiencies, and transporter fluxes for iJCMED4 and culture experiments. In addition to a nearly optimal photosynthetic quotient and central carbon metabolism efficiency, MED4 has made dramatic alterations to redox and phosphorus metabolism across biosynthetic and intermediate pathways. We propose that reductions in phosphate reaction

  10. Potential health impacts from range fires at Aberdeen Proving Ground, Maryland.

    Energy Technology Data Exchange (ETDEWEB)

    Willians, G.P.; Hermes, A.M.; Policastro, A.J.; Hartmann, H.M.; Tomasko, D.

    1998-03-01

    This study uses atmospheric dispersion computer models to evaluate the potential for human health impacts from exposure to contaminants that could be dispersed by fires on the testing ranges at Aberdeen Proving Ground, Maryland. It was designed as a screening study and does not estimate actual human health risks. Considered are five contaminants possibly present in the soil and vegetation from past human activities at APG--lead, arsenic, trichloroethylene (TCE), depleted uranium (DU), and dichlorodiphenyltrichloroethane (DDT); and two chemical warfare agents that could be released from unexploded ordnance rounds heated in a range fire--mustard and phosgene. For comparison, dispersion of two naturally occurring compounds that could be released by burning of uncontaminated vegetation--vinyl acetate and 2-furaldehyde--is also examined. Data from previous studies on soil contamination at APG are used in conjunction with conservative estimates about plant uptake of contaminants, atmospheric conditions, and size and frequency of range fires at APG to estimate dispersion and possible human exposure. The results are compared with US Environmental Protection Agency action levels. The comparisons indicate that for all of the anthropogenic contaminants except arsenic and mustard, exposure levels would be at least an order of magnitude lower than the corresponding action levels. Because of the compoundingly conservative nature of the assumptions made, they conclude that the potential for significant human health risks from range fires is low. The authors recommend that future efforts be directed at fire management and control, rather than at conducting additional studies to more accurately estimate actual human health risk from range fires.

  11. An Analysis of the Extratropical Transition of Hurricane Arthur (2014) from a JPSS Proving Ground Perspective

    Science.gov (United States)

    Folmer, M. J.; Berndt, E.; Halverson, J. B.; Dunion, J. P.; Goldberg, M.

    2015-12-01

    As part of the GOES-R and JPSS Satellite Proving Grounds, multiple proxy and operational products were available to analyze and forecast the complex evolution of Hurricane Arthur (2014). The National Hurricane Center, Ocean Prediction Center, Weather Prediction Center, and NESDIS Satellite Analysis Branch were able to monitor the tropical and extratropical transition of Arthur using various convective and red, green, blue (RGB) products that have been introduced in recent years. During the extratropical transition, the Air Mass RGB (AM RGB) product and AIRS/CrIS ozone products were available as a compliment to water vapor imagery to identify the upper-level low with associated stratospheric drying that absorbed much of Arthur's energy. The AM RGB product provides forecasters with an enhanced view of various air masses that are combined into a single image and can help differentiate between possible stratospheric/tropospheric interactions, moist tropical air masses, and cool, continental/maritime air masses. Even though this product provides a wealth of qualitative information about the horizontal distribution of synoptic features, forecasters are also interested in more quantitative information such as the vertical distribution of temperature, moisture, and ozone which impact the coloring of the resulting AM RGB. Currently, NOAA Unique CrIS/ATMS Processing System (NUCAPS) temperature and moisture soundings are available in AWIPS-II as a point-based display. Traditionally, soundings are used to anticipate and forecast severe convection, however unique and valuable information can be gained from soundings for other forecasting applications, such as extratropical transition, especially in data sparse regions. Additional research has been conducted to look at how NUCAPS soundings might help forecasters identify the pre-extratropical transition environment, leading to earlier diagnosis and better public advisories. NUCAPS soundings, AIRS soundings, NOAA G-IV GPS

  12. The U.S. Army Occupational and Environmental Medicine Residency at Aberdeen Proving Ground, Maryland: 1960-1996.

    Science.gov (United States)

    Gaydos, Joel C; Mallon, Timothy M; Rice, William A

    2016-11-01

    Reorganization of the Army and critical assessment of Army Graduate Medical Education programs prompted the Occupational and Environmental Medicine (OEM) Consultant to the Army Surgeon General to initiate a review of current Army OEM residency training. Available information indicated the Army OEM residency at Aberdeen Proving Ground, MD, was the first and longest operating Army OEM residency. Describing this residency was identified as the first step in the review, with the objectives of determining why the residency was started and sustained and its relevance to the needs of the Army. Records possibly related to the residency were reviewed, starting with 1954 since certification of physicians as Occupation Medicine specialists began in 1955. Interviews were conducted with selected physicians who had strong affiliations with the Army residency and the practice of Army OEM. The Army OEM residency began in 1960 and closed in 1996 with the transfer of Army OEM residency training to the Uniformed Services University of the Health Sciences, Bethesda, MD. Over 36 years, 47 uniformed residency graduates were identified; 44 were from the Army. Forty graduated between 1982 and 1996. The OEM residency was part of a dynamic cycle. Uniformed OEM leaders identified the knowledge and skills required of military OEM physicians and where these people should be stationed in the global Army. Rotations at military sites to acquire the needed knowledge and skills were integrated into the residency. Residency graduates were assigned to positions where they were needed. Having uniformed residents and preceptors facilitated the development of trust with military leaders and access to areas where OEM physician skills and knowledge could have a positive impact. Early reports indicated the residency was important in recruiting and retaining OEM physicians, with emphasis placed on supporting the Army industrial base. The late 1970s into the 1990s was a more dynamic period. There was

  13. Inorganic and organic ground-water chemistry in the Canal Creek area of Aberdeen Proving Ground, Maryland

    Science.gov (United States)

    Lorah, M.M.; Vroblesky, D.A.

    1989-01-01

    Groundwater chemical data were collected from November 1986 through April 1987 in the first phase of a 5-year study to assess the possibility of groundwater contamination in the Canal Creek area of Aberdeen Proving Ground, Maryland. Water samples were collected from 87 observation wells screened in Coastal Plain sediments; 59 samples were collected from the Canal Creek aquifer, 18 from the overlying surficial aquifer, and 10 from the lower confined aquifer. Dissolved solids, chloride, iron, manganese, fluoride, mercury, and chromium are present in concentrations that exceed the Federal maximum contaminant levels for drinking water. Elevated chloride and dissolved-solids concentrations appear to be related from contaminant plumes but also could result from brackish-water intrusion. Excessive concentrations of iron and manganese were the most extensive water quality problems found among the inorganic constituents and are derived from natural dissolution of minerals and oxide coatings in the aquifer sediments. Volatile organic compounds are present in the Canal Creek and surficial aquifers, but samples from the lower confined aquifer do not show any evidence of contamination by inorganic or organic chemicals. The volatile organic contaminants detected in the groundwater and their maximum concentrations (in micrograms/L) include 1,1,2,2- tetrachloroethane (9,000); carbon tetrachloride (480); chloroform (460); 1,1,2-trichloroethane (80); 1,2-dichloroethane (990); 1,1-dichloroethane (3.1); tetrachloroethylene (100); trichloroethylene (1,800); 1,2-trans- dichloroethylene (1,200); 1,1-dichloroethylene (4.4); vinyl chloride (140); benzene (70); and chlorobenzene (39). On the basis of information on past activities in the study area, some sources of the volatile organic compounds include: (1) decontaminants and degreasers; (2) clothing-impregnating operations; (3) the manufacture of impregnite material; (4) the manufacture of tear gas; and (5) fuels used in garages and at

  14. Hydrogeology and water quality in the Graces Quarters area of Aberdeen Proving Ground, Maryland

    Science.gov (United States)

    Tenbus, Frederick J.; Blomquist, Joel D.

    1995-01-01

    Graces Quarters was used for open-air testing of chemical-warfare agents from the late 1940's until 1971. Testing and disposal activities have resulted in the contamination of ground water and surface water. The hydrogeology and water quality were examined at three test areas, four disposal sites, a bunker, and a service area on Graces Quarters. Methods of investigation included surface and borehole geophysics, water-quality sampling, water- level measurement, and hydrologic testing. The hydrogeologic framework is complex and consists of a discontinuous surficial aquifer, one or more upper confining units, and a confined aquifer system. Directions of ground-water flow vary spatially and temporally, and results of site investigations show that ground-water flow is controlled by the geology of the area. The ground water and surface water at Graces Quarters generally are unmineralized; the ground water is mildly acidic (median pH is 5.38) and poorly buffered. Inorganic constituents in excess of certain Federal drinking-water regulations and ambient water-quality criteria were detected at some sites, but they probably were present naturally. Volatile and semivolatile organic com- pounds were detected in the ground water and surface water at seven of the nine sites that were investi- gated. Concentrations of organic compounds at two of the nine sites exceeded Federal drinking-water regulations. Volatile compounds in concentrations as high as 6,000 m/L (micrograms per liter) were detected in the ground water at the site known as the primary test area. Concentrations of volatile compounds detected in the other areas ranged from 0.57 to 17 m/L.

  15. The Use of Succession Planning to Prepare Future Leaders in Selected Federal Agencies at Aberdeen Proving Ground, MD

    Science.gov (United States)

    2011-05-01

    11, January-February 2008). In the 2009 edition of their book, “Execution: The Discipline of Getting Things Done,” Larry Bossidy and Ram Charan make a...responsibilities. Ram Charan of “Execution” notes that 2 in 5 CEOs fail in their first 18 months on the job because of poor selection. The failure can...8 (Mathis, p. 288). the army civilian talent management program Bossidy and Charan make the case that given the many things businesses can’t control

  16. AMR Magnetometer Data on Moving Military Vehicles at Aberdeen Proving Ground

    Science.gov (United States)

    2007-09-01

    BLDG 407 PICATINNY ARSENAL NJ 07806-5000 US ARMY ARDEC ATTN AMSRD-AAR- AEP -S R T KINASEWITZ BLDG 353N PICATINNY ARSENAL NJ 07806-5000 21 US...ARMY INFO SYS ENGRG CMND ATTN AMSEL-IE- TD F JENIA FT HUACHUCA AZ 85613-5300 US ARMY NATL GROUND INTLLGNC CTR ATTN IANG-CE-MA D C LOYD

  17. Operation UPSHOT-KNOTHOLE. Operational Summary, Nevada Proving Grounds, 1 March - 9 June 1953

    Science.gov (United States)

    1982-08-01

    projaing stabi±izing agents were tested including sand-cementt sodium silicateg and lignin , The sand-cemnt test panels showed no damage to the effects of... Lignin proved its valua ana mohan.tc1a stabilizing agent in regions where the peak overpressure was less than 20 psi. Evaluation of these materials from a...selected officer volunp towns trained in culoulating the offscts of atomic wespona,, wase pomi~ tionod in trenches at 2W0 and AM0 Ids fr pom sex (a

  18. Hydrogeology and chemical quality of water and soil at Carroll Island, Aberdeen Proving Ground, Maryland

    Science.gov (United States)

    Tenbus, F.J.; Phillips, S.W.

    1996-01-01

    Carroll Island was used for open-air testing of chemical warfare agents from the late 1940's until 1971. Testing and disposal activities weresuspected of causing environmental contamination at 16 sites on the island. The hydrogeology and chemical quality of ground water, surface water, and soil at these sites were investigated with borehole logs, environmental samples, water-level measurements, and hydrologic tests. A surficial aquifer, upper confining unit, and upper confined aquifer were defined. Ground water in the surficial aquifer generally flows from the east-central part of the island toward the surface-water bodies, butgradient reversals caused by evapotranspiration can occur during dry seasons. In the confined aquifer, hydraulic gradients are low, and hydraulic head is affected by tidal loading and by seasonal pumpage from the west. Inorganic chemistry in the aquifers is affected by brackish-water intrusion from gradient reversals and by dissolution ofcarboniferous shell material in the confining unit.The concentrations of most inorganic constituents probably resulted from natural processes, but some concentrations exceeded Federal water-quality regulations and criteria. Organic compounds were detected in water and soil samples at maximum concentrations of 138 micrograms per liter (thiodiglycol in surface water) and 12 micrograms per gram (octadecanoic acid in soil).Concentrations of organic compounds in ground water exceeded Federal drinking-water regulations at two sites. The organic compounds that weredetected in environmental samples were variously attributed to natural processes, laboratory or field- sampling contamination, fallout from industrial air pollution, and historical military activities.

  19. Hydrogeologic, soil, and water-quality data for j-field, Aberdeen Proving Ground, Maryland, 1989-94

    Science.gov (United States)

    Phelan, D.J.

    1996-01-01

    Disposal of chemical-warfare agents, munitions, and industrial chemicals in J-Field, Aberdeen Proving Ground, Maryland, has resulted in ground-water, surface-water, and soil contamination. This report presents data collected by the U.S. Geological Survey from Novembr 1989 through September 1994 as part of a remedial investigation of J-Field in response to the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). Hydrogeologic data, soil-gas and soil-quality data, and water-qualtiy data are included.

  20. Finding and proving the exact ground state of a generalized Ising model by convex optimization and MAX-SAT

    Science.gov (United States)

    Huang, Wenxuan; Kitchaev, Daniil A.; Dacek, Stephen T.; Rong, Ziqin; Urban, Alexander; Cao, Shan; Luo, Chuan; Ceder, Gerbrand

    2016-10-01

    Lattice models, also known as generalized Ising models or cluster expansions, are widely used in many areas of science and are routinely applied to the study of alloy thermodynamics, solid-solid phase transitions, magnetic and thermal properties of solids, fluid mechanics, and others. However, the problem of finding and proving the global ground state of a lattice model, which is essential for all of the aforementioned applications, has remained unresolved for relatively complex practical systems, with only a limited number of results for highly simplified systems known. In this paper, we present a practical and general algorithm that provides a provable periodically constrained ground state of a complex lattice model up to a given unit cell size and in many cases is able to prove global optimality over all other choices of unit cell. We transform the infinite-discrete-optimization problem into a pair of combinatorial optimization (MAX-SAT) and nonsmooth convex optimization (MAX-MIN) problems, which provide upper and lower bounds on the ground state energy, respectively. By systematically converging these bounds to each other, we may find and prove the exact ground state of realistic Hamiltonians whose exact solutions are difficult, if not impossible, to obtain via traditional methods. Considering that currently such practical Hamiltonians are solved using simulated annealing and genetic algorithms that are often unable to find the true global energy minimum and inherently cannot prove the optimality of their result, our paper opens the door to resolving longstanding uncertainties in lattice models of physical phenomena. An implementation of the algorithm is available at https://github.com/dkitch/maxsat-ising.

  1. Interim progress report addendun - environmental geophysics: Building E5032 decommissioning, Aberdeen Proving Ground, January 1994 resurvey

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, M.D.; McGinnis, L.D.; Benson, M.A.; Borden, H.M.; Padar, C.A.

    1994-12-01

    Geophysical surveying around Building E5032 using three new continuously recording geophysical instruments - two types of electromagnetic induction instruments and a cesium vapor magnetometer that were unavailable at the time of the original survey - has provided additional information for defining the location of buried debris, vaults, tanks, and the drainage/sump system near the building. The dominant geophysical signature around Building E5032 consists of a complex pattern of linear magnetic, electrical-conductivity, and electromagnetic field anomalies that appear to be associated with drainage/sewer systems, ditches, past railway activity, the location for Building T5033 (old number 99A), and the probable location of Building 91. Integrated analysis of data acquired using the three techniques, plus a review of the existing ground-penetrating-radar data, allow a more thorough definition of the sources for the observed anomalies.

  2. Finding and proving the exact ground state of a generalized Ising model by convex optimization and MAX-SAT

    CERN Document Server

    Huang, Wenxuan; Dacek, Stephen; Rong, Ziqin; Urban, Alexander; Cao, Shan; Luo, Chuan; Ceder, Gerbrand

    2016-01-01

    Lattice models, also known as generalized Ising models or cluster expansions, are widely used in many areas of science and are routinely applied to alloy thermodynamics, solid-solid phase transitions, magnetic and thermal properties of solids, and fluid mechanics, among others. However, the problem of finding the true global ground state of a lattice model, which is essential for all of the aforementioned applications, has remained unresolved, with only a limited number of results for highly simplified systems known. In this article, we present the first general algorithm to find the exact ground states of complex lattice models and to prove their global optimality, resolving this fundamental problem in condensed matter and materials theory. We transform the infinite-discrete-optimization problem into a pair of combinatorial optimization (MAX-SAT) and non-smooth convex optimization (MAX-MIN) problems, which provide upper and lower bounds on the ground state energy respectively. By systematically converging th...

  3. SPoRT Participation in the GOES-R and JPSS Proving Grounds

    Science.gov (United States)

    Jedlovec, Gary; Fuell, Kevin; Smith, Matthew

    2013-01-01

    For the last several years, the NASA Short-term Prediction Research and Transition (SPoRT) project at has been working with the various algorithm working groups and science teams to demonstrate the utility of future operational sensors for GOES-R and the suite of instruments for the JPSS observing platforms. For GOES-R, imagery and products have been developed from polar-orbiting sensors such as MODIS and geostationary observations from SEVIRI, simulated imagery, enhanced products derived from existing GOES satellites, and data from ground-based observing systems to generate pseudo or proxy products for the ABI and GLM instruments. The suite of products include GOES-POES basic and RGB hybrid imagery, total lightning flash products, quantitative precipitation estimates, and convective initiation products. SPoRT is using imagery and products from VIIRS, CrIS, ATMS, and OMPS to show the utility of data and products from their operational counterparts on JPSS. The products include VIIRS imagery in swath form, the GOES-POES hybrid, a suite of RGB products including the air mass RGB using water vapor and ozone channels from CrIS, and several DNB products. Over a dozen SPoRT collaborative WFOs and several National Centers are involved in an intensive evaluation of the operational utility of these products.

  4. Investigation of soil contamination at the Riot Control Burning Pit area in J-Field, Aberdeen Proving Ground, Maryland

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Ying-Ya; Yuen, C.R.; Martino, L.

    1996-05-01

    A remedial investigation was conducted to identify soil contamination in the Riot Control Burning Pit area in J-field, Aberdeen Proving Ground, Maryland. The investigation included geophysical surveys to delineate the filled section of the pit, soil-gas surveys to locate the organic contamination area, field X-ray fluorescence measurements along the burning pit to identify the major metal contamination, and surface and subsurface soil analyses to investigate the nature and extent of contamination. This paper presents the results of this investigation

  5. Mean of the top ten percent of NDVI values in the Yuma Proving Ground during monsoon season, 1986-2011

    Science.gov (United States)

    Birtwistle, Amy N; Laituri, Melinda J.; Bledsoe, Brian P.; Friedman, Jonathan M.

    2016-01-01

    This study uses growth in vegetation during the monsoon season measured from LANDSAT imagery as a proxy for measured rainfall. NDVI values from 26 years of pre- and post-monsoon season Landsat imagery were derived across Yuma Proving Ground (YPG) in southwestern Arizona, USA. The LANDSAT imagery (1986-2011) was downloaded from USGS’s GlobeVis website (http://glovis.usgs.gov/). Change in NDVI was calculated within a set of 2,843 Riparian Area Polygons (RAPs) up to 1 km in length defined in ESRI ArcMap 10.2.

  6. Effect of Fe(III) on 1,1,2,2-Tetrachloroethane degradation and vinyl chloride accumulation in wetland sediments of the Aberdeen Proving Ground

    Science.gov (United States)

    Jones, Elizabeth; Voytek, Mary; Lorah, Michelle

    2004-01-01

    1,1,2,2-Tetrachloroethane (TeCA) contaminated groundwater at the Aberdeen Proving Ground discharges through an anaerobic wetland in West Branch Canal Creek (MD), where dechlorination occurs. Two microbially mediated pathways, dichloroelimination and hydrogenolysis, account for most of the TeCA degradation at this site. The dichloroelimination pathways lead to the formation of vinyl chloride (VC), a recalcitrant carcinogen of great concern. The goal of this investigation was to determine whether microbially-available Fe(III) in the wetland surface sediment influenced the fate of TeCA and its daughter products. Differences were identified in the TeCA degradation pathway between microcosms treated with amorphous ferric oxyhydroxide (AFO-treated) and untreated (no AFO) microcosms. TeCA degradation was accompanied by a lower accumulation of VC in AFO-treated microcosms than untreated microcosms. The microcosm incubations and subsequent experiments with the microcosm materials showed that AFO treatment resulted in lower production of VC by (1) shifting TeCA degradation from dichloroelimination pathways to production of a greater proportion of chlorinated ethane products, and (2) decreasing the microbial capability to produce VC from 1,2-dichloroethene (DCE). VC degradation was not stimulated in the presence of Fe(III). Rather, VC degradation occurred readily under methanogenic conditions and was inhibited under Fe(III)-reducing conditions.

  7. New and improved methods for monitoring air quality and the terrestrial environment: Applications at Aberdeen Proving Ground-Edgewood area. Annual report, 1 April--14 November 1997

    Energy Technology Data Exchange (ETDEWEB)

    Bromenshenk, J.J.; Smith, G.C.

    1998-03-01

    Honey bees (Apis mellifera L.) have been shown to be multi-media monitors of chemical exposures and resultant effects. This five-year project has developed an automated system to assess in real-time colony behavioral responses to stressors, both anthropogenic and natural, including inclement weather. Field trials at the Aberdeen Proving Ground-Edgewood included the Old O Field and J field landfills, the Canal Creek and Bush River areas, and a Churchville, MD reference site. Preliminary results show varying concentrations of bioavailable inorganic elements and chlorinated hydrocarbons in bee colonies from all Maryland sites. Industrial solvents in the air inside beehives exhibited the greatest between site differences, with the highest levels occurring in hives near landfills at Old O Field, J Field, and at some sites in the Bush River and Canal Creek areas. Compared to 1996, the 1997 levels of solvents in Old O Field hives decreased by an order of magnitude, and colony performance significantly improved, probably as a consequence of capping the landfill. Recent chemical monitoring accomplishments include development of a new apparatus to quantitatively calibrate TD/GC/MS analysis, a QA/QC assessment of factors that limit the precision of these analyses, and confirmation of transport of aqueous contaminants into the hive. Real-time effects monitoring advances include development of an extensive array of software tools for automated data display, inspection, and numerical analysis and the ability to deliver data from remote locations in real time through Internet or Intranet connections.

  8. Assessment of volatile organic compounds in surface water at West Branch Canal Creek, Aberdeen Proving Ground, Maryland, 1999

    Science.gov (United States)

    Olsen, Lisa D.; Spencer, Tracey A.

    2000-01-01

    The U.S. Geological Survey (USGS) collected 13 surface-water samples and 3 replicates from 5 sites in the West Branch Canal Creek area at Aberdeen Proving Ground from February through August 1999, as a part of an investigation of ground-water contamination and natural attenuation processes. The samples were analyzed for volatile organic compounds, including trichloroethylene, 1,1,2,2-tetrachloroethane, carbon tetrachloride, and chloroform, which are the four major contaminants that were detected in ground water in the Canal Creek area in earlier USGS studies. Field blanks were collected during the sampling period to assess sample bias. Field replicates were used to assess sample variability, which was expressed as relative percent difference. The mean variability of the surface-water replicate analyses was larger (35.4 percent) than the mean variability of ground-water replicate analyses (14.6 percent) determined for West Branch Canal Creek from 1995 through 1996. The higher variability in surface-water analyses is probably due to heterogeneities in the composition of the surface water rather than differences in sampling or analytical procedures. The most frequently detected volatile organic compound was 1,1,2,2- tetrachloroethane, which was detected in every sample and in two of the replicates. The surface-water contamination is likely the result of cross-media transfer of contaminants from the ground water and sediments along the West Branch Canal Creek. The full extent of surface-water contamination in West Branch Canal Creek and the locations of probable contaminant sources cannot be determined from this limited set of data. Tidal mixing, creek flow patterns, and potential effects of a drought that occurred during the sampling period also complicate the evaluation of surface-water contamination.

  9. Long-term ground-water monitoring program and performance-evaluation plan for the extraction system at the former Nike Missile Battery Site, Aberdeen Proving Ground, Maryland

    Science.gov (United States)

    Senus, Michael P.; Tenbus, Frederick J.

    2000-01-01

    This report presents lithologic and ground-water-quality data collected during April and May 2000 in the remote areas of the tidal wetland of West Branch Canal Creek, Aberdeen Proving Ground, Maryland. Contamination of the Canal Creek aquifer with volatile organic compounds has been documented in previous investigations of the area. This study was conducted to investigate areas that were previously inaccessible because of deep mud and shallow water, and to support ongoing investigations of the fate and transport of volatile organic compounds in the Canal Creek aquifer. A unique vibracore drill rig mounted on a hovercraft was used for drilling and ground-water sampling. Continuous cores of the wetland sediment and of the Canal Creek aquifer were collected at five sites. Attempts to sample ground water were made by use of a continuous profiler at 12 sites, without well installation, at a total of 81 depths within the aquifer. Of those 81 attempts, only 34 sampling depths produced enough water to collect samples. Ground-water samples from two sites had the highest concentrations of volatile organic compounds?with total volatile organic compound concentrations in the upper part of the aquifer ranging from about 15,000 to 50,000 micrograms per liter. Ground-water samples from five sites had much lower total volatile organic compound concentrations (95 to 2,100 micrograms per liter), whereas two sites were essentially not contaminated, with total volatile organic compound concentrations less than or equal to 5 micrograms per liter.

  10. Temporal and vertical variation of hydraulic head in aquifers in the Edgewood area, Aberdeen Proving Ground, Maryland

    Science.gov (United States)

    Donnelly, Colleen A.; Tenbus, Fredrick J.

    1998-01-01

    Water-level data and interpretations from previous hydrogeological studies conducted by the U.S. Geological Survey in the Edgewood Area of Aberdeen Proving Ground (APG), Maryland, were compared to determine similarities and differences among the aquifers. Because the sediments that comprise the shallow aquifers are discontinuous, the shallow ground-water-flow systems are local rather than extensive across the Edgewood Area. Hydrogeologic cross sections, hydrographs of water levels, and vertical gradients calculated from previous studies in the Canal Creek area, Graces Quarters, the O-Field area, Carroll Island, and the J-Field area, over periods of record ranging from 1 to 10 years during 1986-97, were used to determine recharge and discharge areas, connections between aquifers, and hydrologic responses of aquifers to natural and anthropogenic stress. Each of the aquifers in the study areas exhibited variation of hydraulic head that was attributed to seasonal changes in recharge. Upward hydraulic gradients and seasonal reversals of vertical hydraulic gradients between aquifers indicate the potential for local ground-water discharge from most of the aquifers that were studied in the Edgewood Area. Hydraulic head in individual aquifers in Graces Quarters and Carroll Island responded to offsite pumping during part of the period of record. Hydraulic head in most of the confined aquifers responded to tidal loading effects from nearby estuaries.

  11. Environmental geophysics of the Pilot Plant on the west branch of Canal Creek, Aberdeen Proving Ground, Maryland

    Energy Technology Data Exchange (ETDEWEB)

    McGinnis, L.D.; Miller, S.F.; Daudt, C.R.; Thompson, M.D.; Borden, H.; Benson, M. [Argonne National Lab., IL (United States). Reclamation Engineering and Geosciences Section; Wrobel, J. [Directorate of Safety, Health, and Environment, Aberdeen Proving Ground, MD (United States)

    1994-05-01

    Plans to demolish and remediate the Pilot Plant complex in the Edgewood Area of Aberdeen Proving Ground have served to initiate a series of nonintrusive, environmental-geophysical studies. The studies are assisting in the location and identification of pipes, tanks, trenches, and liquid waste in the subsurface. Multiple databases have been integrated to provide support for detection of underground utilities and to determine the stratigraphy and lithology of the subsurface. The studies were conducted within the double security fence and exterior to the double fence, down gradient toward the west branch of Canal Creek. To determine if contaminants found in the creek were associated with the Pilot Plant, both the east and west banks were included in the study area. Magnetic, conductivity, inductive emf, and ground-penetrating-radar anomalies outline buried pipes, trenches, and various pieces of hardware associated with building activities. Ground-penetrating-radar imagery also defines a paleovalley cut 30 ft into Potomac Group sediments of Cretaceous age. The paleovalley crosses the site between Building E5654 and the Pilot Plant fence. The valley is environmentally significant because it may control the pathways of contaminants. The Pilot Plant complex was used to manufacture CC2 Impregnite and incapacitating agents; it also served as a production facility for nerve agents.

  12. Historical wildlife dynamics on Dugway Proving Ground: population and disease trends in jack rabbits over two decades. [Lepus californicus

    Energy Technology Data Exchange (ETDEWEB)

    Eberhardt, L.E.; Van Voris, P.

    1986-08-01

    In an effort to determine whether US Army activities on the Dugway Proving Ground (DPG) have had an impact on resident wildlife, intensive studies have been conducted on the biology and ecology of the black-tailed jack rabbit (Lepus californicus) since 1965. in addition, the incidence of endemic diseases in several species of resident wildlife on the DPG have been studied from the late 1950s through the mid-1970s. The objectives of this report are to: (1) compile and summarize the jack rabbit data and some of the disease information that is presently contained only in annual reports; (2) compare the DPG jack rabbit data to data available on other jack rabbit populations; and (3) analyze the data for unusual or unexplained fluctuations in population densities or in incidence of disease.

  13. THE OLKHON GEODYNAMIC PROVING GROUND (LAKE BAIKAL: HIGH RESOLUTION SATELLITE DATA AND GEOLOGICAL MAPS OF NEW GENERATION

    Directory of Open Access Journals (Sweden)

    Valentin S. Fedorovsky

    2015-09-01

    Full Text Available The Olkhon region of the Western Pribaikalie is highly attractive for geologists due to the presence of diverse metamorphic complexes and highly complicated combinations of folded structures in this region. The Olkhon region is located within the area of the Pribaikalsky National Park of Russia. At abundant outcrops in the subject area, various geological aspects resulting from the Early Palaeozoic collision system can be studied in detail. By its parameters, the subject area can be considered a «geodynamic proving ground». In recent years, abundant aerospace materials on the area have been accumulated, and long-term field studies resulted in many discoveries and findings which encourage critical revision of the initial conceptions. The material available allows compilation of a new package of geological maps in hard and electronic versions.

  14. JPSS Proving Ground Activities with NASA's Short-term Prediction Research and Transition (SPoRT) Center

    Science.gov (United States)

    Schultz, L. A.; Smith, M. R.; Fuell, K.; Stano, G. T.; LeRoy, A.; Berndt, E.

    2015-12-01

    Instruments aboard the Joint Polar Satellite System (JPSS) series of satellites will provide imagery and other data sets relevant to operational weather forecasts. To prepare current and future weather forecasters in application of these data sets, Proving Ground activities have been established that demonstrate future JPSS capabilities through use of similar sensors aboard NASA's Terra and Aqua satellites, and the S-NPP mission. As part of these efforts, NASA's Short-term Prediction Research and Transition (SPoRT) Center in Huntsville, Alabama partners with near real-time providers of S-NPP products (e.g., NASA, UW/CIMSS, UAF/GINA, etc.) to demonstrate future capabilities of JPSS. This includes training materials and product distribution of multi-spectral false color composites of the visible, near-infrared, and infrared bands of MODIS and VIIRS. These are designed to highlight phenomena of interest to help forecasters digest the multispectral data provided by the VIIRS sensor. In addition, forecasters have been trained on the use of the VIIRS day-night band, which provides imagery of moonlit clouds, surface, and lights emitted by human activities. Hyperspectral information from the S-NPP/CrIS instrument provides thermodynamic profiles that aid in the detection of extremely cold air aloft, helping to map specific aviation hazards at high latitudes. Hyperspectral data also support the estimation of ozone concentration, which can highlight the presence of much drier stratospheric air, and map its interaction with mid-latitude or tropical cyclones to improve predictions of their strengthening or decay. Proving Ground activities are reviewed, including training materials and methods that have been provided to forecasters, and forecaster feedback on these products that has been acquired through formal, detailed assessment of their applicability to a given forecast threat or task. Future opportunities for collaborations around the delivery of training are proposed

  15. Demonstration of the Military Ecological Risk Assessment Framework (MERAF): Apache Longbow - Hell Missile Test at Yuma Proving Ground

    Energy Technology Data Exchange (ETDEWEB)

    Efroymson, R.A.

    2002-05-09

    This ecological risk assessment for a testing program at Yuma Proving Ground, Arizona, is a demonstration of the Military Ecological Risk Assessment Framework (MERAF; Suter et al. 2001). The demonstration is intended to illustrate how risk assessment guidance concerning-generic military training and testing activities and guidance concerning a specific type of activity (e.g., low-altitude aircraft overflights) may be implemented at a military installation. MERAF was developed with funding from the Strategic Research and Development Program (SERDP) of the Department of Defense. Novel aspects of MERAF include: (1) the assessment of risks from physical stressors using an ecological risk assessment framework, (2) the consideration of contingent or indirect effects of stressors (e.g., population-level effects that are derived from habitat or hydrological changes), (3) the integration of risks associated with different component activities or stressors, (4) the emphasis on quantitative risk estimates and estimates of uncertainty, and (5) the modularity of design, permitting components of the framework to be used in various military risk assessments that include similar activities. The particular subject of this report is the assessment of ecological risks associated with a testing program at Cibola Range of Yuma Proving Ground, Arizona. The program involves an Apache Longbow helicopter firing Hellfire missiles at moving targets, i.e., M60-A1 tanks. Thus, the three component activities of the Apache-Hellfire test were: (1) helicopter overflight, (2) missile firing, and (3) tracked vehicle movement. The demonstration was limited, to two ecological endpoint entities (i.e., potentially susceptible and valued populations or communities): woody desert wash communities and mule deer populations. The core assessment area is composed of about 126 km{sup 2} between the Chocolate and Middle Mountains. The core time of the program is a three-week period, including fourteen days of

  16. Long-term fate of depleted uranium at Aberdeen and Yuma Proving Grounds: Human health and ecological risk assessments

    Energy Technology Data Exchange (ETDEWEB)

    Ebinger, M.H.; Beckman, R.J.; Myers, O.B. [Los Alamos National Lab., NM (United States); Kennedy, P.L.; Clements, W.; Bestgen, H.T. [Colorado State Univ., Ft. Collins, CO (United States). Dept. of Fishery and Wildlife Biology

    1996-09-01

    The purpose of this study was to evaluate the immediate and long-term consequences of depleted uranium (DU) in the environment at Aberdeen Proving Ground (APG) and Yuma Proving Ground (YPG) for the Test and Evaluation Command (TECOM) of the US Army. Specifically, we examined the potential for adverse radiological and toxicological effects to humans and ecosystems caused by exposure to DU at both installations. We developed contaminant transport models of aquatic and terrestrial ecosystems at APG and terrestrial ecosystems at YPG to assess potential adverse effects from DU exposure. Sensitivity and uncertainty analyses of the initial models showed the portions of the models that most influenced predicted DU concentrations, and the results of the sensitivity analyses were fundamental tools in designing field sampling campaigns at both installations. Results of uranium (U) isotope analyses of field samples provided data to evaluate the source of U in the environment and the toxicological and radiological doses to different ecosystem components and to humans. Probabilistic doses were estimated from the field data, and DU was identified in several components of the food chain at APG and YPG. Dose estimates from APG data indicated that U or DU uptake was insufficient to cause adverse toxicological or radiological effects. Dose estimates from YPG data indicated that U or DU uptake is insufficient to cause radiological effects in ecosystem components or in humans, but toxicological effects in small mammals (e.g., kangaroo rats and pocket mice) may occur from U or DU ingestion. The results of this study were used to modify environmental radiation monitoring plans at APG and YPG to ensure collection of adequate data for ongoing ecological and human health risk assessments.

  17. Ground-water, surface-water, and bottom-sediment contamination in the O-field area, Aberdeen Proving Ground, Maryland, and the possible effects of selected remedial actions on ground water

    Science.gov (United States)

    Vroblesky, Don A.; Lorah, Michelle M.; Oliveros, James P.

    1995-01-01

    Disposal of munitions and chemical-warfare substances has introduced inorganic and organic contaminants to the ground water, surface water, and bottom sediment at O-Field, in the Edgewood area of Aberdeen Proving Ground, Maryland. Contaminants include chloride, arsenic, transition metals, chlorinated aliphatic hydrocarbons, aromatic compounds, and organosulfur and organophosphorus compounds. The hydrologic effects of several remedial actions were estimated by use of a ground-water-flow model. The remedial actions examined were an impermeable covering, encapsulation, subsurface barriers, a ground-water drain, pumping of wells to manage water levels or to remove contaminated ground water for treatment, and no action.

  18. Lithologic and ground-water-quality data collected using Hoverprobe drilling techniques at the West Branch Canal Creek wetland, Aberdeen Proving Ground, Maryland, April-May 2000

    Science.gov (United States)

    Phelan, Daniel J.; Senus, Michael P.; Olsen, Lisa D.

    2001-01-01

    This report presents lithologic and groundwater- quality data collected during April and May 2000 in the remote areas of the tidal wetland of West Branch Canal Creek, Aberdeen Proving Ground, Maryland. Contamination of the Canal Creek aquifer with volatile organic compounds has been documented in previous investigations of the area. This study was conducted to investigate areas that were previously inaccessible because of deep mud and shallow water, and to support ongoing investigations of the fate and transport of volatile organic compounds in the Canal Creek aquifer. A unique vibracore drill rig mounted on a hovercraft was used for drilling and groundwater sampling. Continuous cores of the wetland sediment and of the Canal Creek aquifer were collected at five sites. Attempts to sample ground water were made by use of a continuous profiler at 12 sites, without well installation, at a total of 81 depths within the aquifer. Of those 81 attempts, only 34 sampling depths produced enough water to collect samples. Ground-water samples from two sites had the highest concentrations of volatile organic compounds?with total volatile organic compound concentrations in the upper part of the aquifer ranging from about 15,000 to 50,000 micrograms per liter. Ground-water samples from five sites had much lower total volatile organic compound concentrations (95 to 2,100 micrograms per liter), whereas two sites were essentially not contaminated, with total volatile organic compound concentrations less than or equal to 5 micrograms per liter.

  19. Military Base Realignments and Closures: Army is Developing Plans to Transfer Functions from Fort Monmouth, New Jersey, to Aberdeen Proving Ground, Maryland, but Challenges Remain

    National Research Council Canada - National Science Library

    2008-01-01

    ...) close Fort Monmouth, New Jersey, and realign most of its technical functions to Aberdeen Proving Ground, Maryland, as one of 182 recommendations in the 2005 base realignment and closure (BRAC) round...

  20. Assessment of volatile organic compounds in surface water at Canal Creek, Aberdeen Proving Ground, Maryland, November 1999-September 2000

    Science.gov (United States)

    Phelan, Daniel J.; Olsen, Lisa D.; Senus, Michael P.; Spencer, Tracey A.

    2001-01-01

    The purpose of this report is to describe the occurrence and distribution of volatile organic compounds in surface-water samples collected by the U.S. Geological Survey in the Canal Creek area of Aberdeen Proving Ground, Maryland, from November 1999 through September 2000. The report describes the differences between years with below normal and normal precipitation, the effects of seasons, tide stages, and location on volatile organic compound concentrations in surface water, and provides estimates of volatile organic concentration loads to the tidal Gunpowder River. Eighty-four environmental samples from 20 surface-water sites were analyzed. As many as 13 different volatile organic compounds were detected in the samples. Concentrations of volatile organic compounds in surface-water samples ranged from below the reporting limit of 0.5 micrograms per liter to a maximum of 50.2 micrograms per liter for chloroform. Chloroform was detected most frequently, and was found in 55 percent of the environmental samples that were analyzed for volatile organic compounds (46 of 84 samples). Carbon tetrachloride was detected in 56 percent of the surface-water samples in the tidal part of the creek (34 of 61 samples), but was only detected in 3 of 23 samples in the nontidal part of the creek. 1,1,2,2-Tetrachloroethane was detected in 43 percent of the tidal samples (26 of 61 samples), but was detected at only two nontidal sites and only during November 1999. Three samples were collected from the tidal Gunpowder River about 300 feet from the mouth of Canal Creek in May 2000, and none of the samples contained volatile organic compound concentrations above detection levels. Volatile organic compound concentrations in surface water were highest in the reaches of the creek adjacent to the areas with the highest known levels of ground-water contamination. The load of total volatile organic compounds from Canal Creek to the Gunpowder River is approximately 1.85 pounds per day (0

  1. Changes in ground-water quality in the Canal Creek Aquifer between 1995 and 2000-2001, West Branch Canal Creek area, Aberdeen Proving Ground, Maryland

    Science.gov (United States)

    Phelan, Daniel J.; Fleck, William B.; Lorah, Michelle M.; Olsen, Lisa D.

    2002-01-01

    Since 1917, Aberdeen Proving Ground, Maryland has been the primary chemical-warfare research and development center for the U.S. Army. Ground-water contamination has been documented in the Canal Creek aquifer because of past disposal of chemical and ordnance manufacturing waste. Comprehensive sampling for volatile organic compounds in ground water by the U.S. Geological Survey in the West Branch Canal Creek area was done in June?October 1995 and June?August 2000. The purpose of this report is (1) to compare volatile organic compound concentrations and determine changes in the ground-water contaminant plumes along two cross sections between 1995 and 2000, and (2) to incorporate data from new piezometers sampled in spring 2001 into the plume descriptions. Along the southern cross section, total concentrations of volatile organic compounds in 1995 were determined to be highest in the landfill area east of the wetland (5,200 micrograms per liter), and concentrations were next highest deep in the aquifer near the center of the wetland (3,300 micrograms per liter at 35 feet below land surface). When new piezometers were sampled in 2001, higher carbon tetrachloride and chloroform concentrations (2,000 and 2,900 micrograms per liter) were detected deep in the aquifer 38 feet below land surface, west of the 1995 sampling. A deep area in the aquifer close to the eastern edge of the wetland and a shallow area just east of the creek channel showed declines in total volatile organic compound concentrations of more than 25 percent, whereas between those two areas, con-centrations generally showed an increase of greater than 25 percent between 1995 and 2000. Along the northern cross section, total concentrations of volatile organic compounds in ground water in both 1995 and 2000 were determined to be highest (greater than 2,000 micrograms per liter) in piezometers located on the east side of the section, farthest from the creek channel, and concentrations were progressively lower

  2. Characterization of Preferential Ground-Water Seepage From a Chlorinated Hydrocarbon-Contaminated Aquifer to West Branch Canal Creek, Aberdeen Proving Ground, Maryland, 2002-04

    Science.gov (United States)

    Majcher, Emily H.; Phelan, Daniel J.; Lorah, Michelle M.; McGinty, Angela L.

    2007-01-01

    Wetlands act as natural transition zones between ground water and surface water, characterized by the complex interdependency of hydrology, chemical and physical properties, and biotic effects. Although field and laboratory demonstrations have shown efficient natural attenuation processes in the non-seep wetland areas and stream bottom sediments of West Branch Canal Creek, chlorinated volatile organic compounds are present in a freshwater tidal creek at Aberdeen Proving Ground, Maryland. Volatile organic compound concentrations in surface water indicate that in some areas of the wetland, preferential flow paths or seeps allow transport of organic compounds from the contaminated sand aquifer to the overlying surface water without undergoing natural attenuation. From 2002 through 2004, the U.S. Geological Survey, in cooperation with the Environmental Conservation and Restoration Division of the U.S. Army Garrison, Aberdeen Proving Ground, characterized preferential ground-water seepage as part of an ongoing investigation of contaminant distribution and natural attenuation processes in wetlands at this site. Seep areas were discrete and spatially consistent during thermal infrared surveys in 2002, 2003, and 2004 throughout West Branch Canal Creek wetlands. In these seep areas, temperature measurements in shallow pore water and sediment more closely resembled those in ground water than those in nearby surface water. Generally, pore water in seep areas contaminated with chlorinated volatile organic compounds had lower methane and greater volatile organic compound concentrations than pore water in non-seep wetland sediments. The volatile organic compounds detected in shallow pore water in seeps were spatially similar to the dominant volatile organic compounds in the underlying Canal Creek aquifer, with both parent and anaerobic daughter compounds detected. Seep locations characterized as focused seeps contained the highest concentrations of chlorinated parent compounds

  3. Constrained Parameterization of the Multichannel Analysis of Surface Waves Approach with Application at Yuma Proving Ground, Arizona

    Science.gov (United States)

    Schwenk, Jacob Tyler

    Field data from Yuma Proving Ground, Arizona was used to test the feasibility of merging common multichannel analysis of surface waves (MASW) processing routines with mode-consistent shear-wave refraction traveltime tomography and synthetic modeling to optimize and constrain inversion results. Shear-wave first-arrival refraction tomography was used to enhance layer-model resolution and refine the MASW layer model with independent body-wave information. Shear-wave tomograms suggested a high-velocity layer, not found in initial 'smooth' MASW velocity sections that were used as initial models for tomographic inversion. Increasing the stratification of the MASW layer model, to generally match tomogram structure, resulted in a higher-resolution MASW model constrained through joint analysis. This mutual analysis of shear-wave velocity (Vs) provided multiplicity to the structural interpretation of the site. Constrained-parameterization MASW results, compressional-wave tomography (Vp:Vs ratio), and density well logs populated a 2D model for numerical modeling, which was manually updated over several iterations to converge upon the site's first-arrival and dispersion characteristics. Further evaluation of the synthetic seismograms gave insight into the relationship between acquisition geometry (offset selection) and the associated dispersion-image character. Furthermore, modeling gave a secondary measurement on depth to half-space, velocity structure, and relative Vp:Vs ratios, which formulated a final MASW profile. The gradual change of the earth model, given an evolving hierarchy of constraint, is seen as the main finding of this thesis. The calculated movement towards a higher-resolution inversion based on joint geophysical measurements, analysis, and interpretation, engenders a constrained-parameterization solution with highest confidence.

  4. Remedial investigation sampling and analysis plan for J-Field, Aberdeen Proving Ground, Maryland: Volume 2, Quality Assurance Project Plan

    Energy Technology Data Exchange (ETDEWEB)

    Prasad, S.; Martino, L.; Patton, T.

    1995-03-01

    J-Field encompasses about 460 acres at the southern end of the Gunpowder Neck Peninsula in the Edgewood Area of APG (Figure 2.1). Since World War II, the Edgewood Area of APG has been used to develop, manufacture, test, and destroy chemical agents and munitions. These materials were destroyed at J-Field by open burning and open detonation (OB/OD). For the purposes of this project, J-Field has been divided into eight geographic areas or facilities that are designated as areas of concern (AOCs): the Toxic Burning Pits (TBP), the White Phosphorus Burning Pits (WPP), the Riot Control Burning Pit (RCP), the Robins Point Demolition Ground (RPDG), the Robins Point Tower Site (RPTS), the South Beach Demolition Ground (SBDG), the South Beach Trench (SBT), and the Prototype Building (PB). The scope of this project is to conduct a remedial investigation/feasibility study (RI/FS) and ecological risk assessment to evaluate the impacts of past disposal activities at the J-Field site. Sampling for the RI will be carried out in three stages (I, II, and III) as detailed in the FSP. A phased approach will be used for the J-Field ecological risk assessment (ERA).

  5. Evaluation of a laser equipped rifle for the US Army Human Engineering Laboratory, Aberdeen Proving Ground, Maryland, January 1977. Nonionizing radiation protection special study

    Energy Technology Data Exchange (ETDEWEB)

    Lyon, T.L.; Del Valle, P.F.

    1977-01-01

    A special study of the optical radiation hazards associated with the operation of a He-Ne laser mounted to an American International Corporation Model 180 Law Enforcement Rifle was performed by this Agency. Radiometric measurements were conducted on 11 January 1977, for the US Army Human Engineering Laboratory at Aberdeen Proving Ground. It was determined that the protection standards for momentary viewing were exceeded out to a hazard distance of 9 m and to 100 m when viewing through an optical instrument. Long-term staring at the laser from within the beam exceeded the protection standards out to a caution distance of 490 m. (Author)

  6. In situ analysis of soil at an open burning/open detonation disposal facility: J-Field, Aberdeen Proving Ground, Maryland

    Energy Technology Data Exchange (ETDEWEB)

    Martino, L.; Cho, E. [Argonne National Lab., Washington, DC (United States); Wrobel, J. [US Army Directorate of Safety, Health, and the Environment, Aberdeen Proving Ground, MD (United States)

    1994-10-01

    Investigators have used a field-portable X-Ray Fluorescence (XRF) Analyzer to screen soils for a suite of metals indicative of the open burning and open detonation (OB/OD) activities that occurred at the J-Field site at Aberdeen Proving Ground, Maryland. The field XRF results were incorporated into a multiphase investigation of contaminants at the Toxic Burning Pits Area of Concern at J-Field. The authors determined that the field-portable XRF unit used for the study and the general concept of field XRF screening are invaluable tools for investigating an OB/OD site where intrusive sampling techniques could present unacceptable hazards to site workers.

  7. Preliminary assessment of microbial communities and biodegradation of chlorinated volatile organic compounds in wetlands at Cluster 13, Lauderick Creek area, Aberdeen Proving Ground, Maryland

    Science.gov (United States)

    Lorah, Michelle M.; Voytek, Mary A.; Spencer, Tracey A.

    2003-01-01

    A preliminary assessment of the microbial communities and biodegradation processes for chlorinated volatile organic compounds was con-ducted by the U.S. Geological Survey in wetlands at the Cluster 13, Lauderick Creek area at Aberdeen Proving Ground, Maryland. The U.S. Geological Survey collected wetland sediment samples from 11 sites in the Lauderick Creek area for microbial analyses, and used existing data to evaluate biodegradation processes and rates. The bacterial and methanogen communities in the Lauderick Creek wetland sediments were similar to those observed in a previous U.S. Geological Survey study at the West Branch Canal Creek wet-land area, Aberdeen Proving Ground. Evaluation of the degradation rate of 1,1,2,2-tetrachloroethane and the daughter compounds produced also showed similar results for the two wetlands. How-ever, a vertical profile of contaminant concentra-tions in the wetlands was available at only one site in the Lauderick Creek area, and flow velocities in the wetland sediment are unknown. To better evaluate natural attenuation processes and rates in the wetland sediments at Lauderick Creek, chemi-cal and hydrologic measurements are needed along ground-water flowpaths in the wetland at additional sites and during different seasons. Nat-ural attenuation in the wetlands, enhanced biore-mediation, and constructed wetlands could be feasible remediation methods for the chlorinated volatile organic compounds discharging in the Lauderick Creek area. The similarities in the microbial communities and biodegradation pro-cesses at the Lauderick Creek and West Branch Canal Creek areas indicate that enhanced bioreme-diation techniques currently being developed for the West Branch Canal Creek wetland area would be transferable to this area.

  8. Water-quality and water-level data for a freshwater tidal wetland, West Branch Canal Creek, Aberdeen Proving Ground, Maryland, October 1998-September 1999

    Science.gov (United States)

    Spencer, Tracey A.; Olsen, Lisa D.; Lorah, Michelle M.; Mount, Mastin M.

    2000-01-01

    This report presents water-quality data for ground-water and surface-water samples and water-level data collected by the U.S. Geological Survey from October 1998 through September 1999 at West Branch Canal Creek, Aberdeen Proving Ground, Maryland. The report also provides a description of the sampling and analytical methods that were used to collect and analyze the samples, and includes an evaluation of the quality-assurance data. The ground-water sampling network includes 88 wells or piezometers, including four 2-inch wells, two 4-inch wells, thirty 0.75-inch piezo-meters, and fifty-two 0.25-inch piezometers. Water levels were measured in 105 wells or piezometers. Surface-water samples were collected at five sites. Samples were collected from wells and 0.75-inch piezometers for measurement of field parameters, and analysis of inorganic and organic constituents during three sampling rounds: March, May through June, and July through August of 1999. Inorganic constituents and organic constituents were analyzed in samples collected from 0.25-inch piezometers during three sampling rounds in February through March, May, and September of 1999. Water levels were measured in October and November of 1998, and in February and May of 1999. Surface-water samples were collected between February and August of 1999 for analysis of organic constituents.

  9. Focused feasibility study for surface soil at the main pits and pushout area, J-field toxic burning pits area, Aberdeen Proving Ground, Maryland

    Energy Technology Data Exchange (ETDEWEB)

    Patton, T.; Benioff, P.; Biang, C.; Butler, J. [and others

    1996-06-01

    The Environmental Management Division of Aberdeen Proving Ground (APG), Maryland, is conducting a remedial investigation and feasibility study of the J-Field area at APG pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act, as amended (CERCLA). J-Field is located within the Edgewood Area of APG in Harford County, Maryland. Since World War II, activities in the Edgewood Area have included the development, manufacture, testing, and destruction of chemical agents and munitions. These materials were destroyed at J-Field by open burning/open detonation. Portions of J-Field continue to be used for the detonation and disposal of unexploded ordnance (UXO) by open burning/open detonation under authority of the Resource Conservation and Recovery Act.

  10. Proceedings of the Scientific Conference on Obscuration and Aerosol Research Held in Aberdeen Proving Ground, Maryland on 21-24 June 1988

    Science.gov (United States)

    1989-06-01

    CRDEC, U. S. Army, 1988 J. C. Carli anA T R. Brock. "Prnnagation of laser breakdown and detonation waves in transparent droplets", Optics. Letters 13...PHYSICS LAB APG, MD21010-5423 JOHN HOPKINS ROAD LAUREL, MD 20707 LORCAN FOLAN DAVID FREUD POLYTECHNIC INSTITUTE OF NEW YORK (301) 792-6260 PHYSICS DEPT

  11. Md Naimuddin

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics. Md Naimuddin. Articles written in Pramana – Journal of Physics. Volume 79 Issue 5 November 2012 pp 1255-1258 Poster Presentations. Model unspecific search for new physics in collision at √s=7 TeV · Shivali Malhotra Md Naimuddin Thomas Hebbeker Arnd Meyer ...

  12. Metadata (MD)

    Science.gov (United States)

    Robert E. Keane

    2006-01-01

    The Metadata (MD) table in the FIREMON database is used to record any information about the sampling strategy or data collected using the FIREMON sampling procedures. The MD method records metadata pertaining to a group of FIREMON plots, such as all plots in a specific FIREMON project. FIREMON plots are linked to metadata using a unique metadata identifier that is...

  13. Ground-based measurements of anthropogenic column sulfur dioxide and nitrogen dioxide at Frostburg, MD in November 2010 and comparison with aircraft and OMI/AURA satellite measurements

    Science.gov (United States)

    Spinei, E.; Mount, G. H.; Herman, J. R.; Cede, A.; Abuhassan, N.; Stehr, J. W.; Brent, L. C.; He, H.; Arkinson, H.; Dickerson, R. R.; Krotkov, N. A.; Yang, K.; Castro, M.; Baker, D.; Hoffman, J.

    2011-12-01

    Sulfur dioxide, a trace gas regulated by the USEPA, affects human health, causes acid rain, and contributes to the production of sulfate aerosols. The largest sources of SO2 emissions in the US are coal-fired power plants in the Ohio river valley region. Strong anthropogenic emissons and transport of SO2 have been globally observed by the Dutch-Finnish Ozone Monitoring Instrument (OMI) on the NASA AURA satellite since October 2004. The derivation of satellite vertical columns of SO2 is difficult due to lower sensor sensitivity in the PBL, uncertainties associated with aerosol loading, cloud cover, and other factors. In November 2010, the first combined ground/AURA OMI measurements of anthropogenic SO2 and other trace gases were made from Frostburg State University, MD downwind of large power plants by ground-based instruments observing the direct sun and multi-axis scattered skylight, airborne instrumentation, and ground-based insitu instruments to validate the OMI SO2 measurements. The weather was generally clear and aerosol optical thickness was generally low during the campaign and well characterized by the measurements. This presentation will describe the use of SO2 profile measurements from the aircraft and combined direct sun/MAX-DOAS measurements from the ground to derive SO2 vertical column density for comparison with OMI SO2. Similar comparisons from ground-based observations will be made for NO2.

  14. Microbial Consortia Development and Microcosm and Column Experiments for Enhanced Bioremediation of Chlorinated Volatile Organic Compounds, West Branch Canal Creek Wetland Area, Aberdeen Proving Ground, Maryland

    Science.gov (United States)

    Lorah, Michelle M.; Majcher, Emily H.; Jones, Elizabeth J.; Voytek, Mary A.

    2008-01-01

    Chlorinated solvents, including 1,1,2,2-tetrachloroethane, tetrachloroethene, trichloroethene, carbon tetrachloride, and chloroform, are reaching land surface in localized areas of focused ground-water discharge (seeps) in a wetland and tidal creek in the West Branch Canal Creek area, Aberdeen Proving Ground, Maryland. In cooperation with the U.S. Army Garrison, Aberdeen Proving Ground, Maryland, the U.S. Geological Survey is developing enhanced bioremediation methods that simulate the natural anaerobic degradation that occurs without intervention in non-seep areas of the wetland. A combination of natural attenuation and enhanced bioremediation could provide a remedy for the discharging ground-water plumes that would minimize disturbance to the sensitive wetland ecosystem. Biostimulation (addition of organic substrate or nutrients) and bioaugmentation (addition of microbial consortium), applied either by direct injection at depth in the wetland sediments or by construction of a permeable reactive mat at the seep surface, were tested as possible methods to enhance anaerobic degradation in the seep areas. For the first phase of developing enhanced bioremediation methods for the contaminant mixtures in the seeps, laboratory studies were conducted to develop a microbial consortium to degrade 1,1,2,2-tetrachloroethane and its chlorinated daughter products under anaerobic conditions, and to test biostimulation and bioaugmentation of wetland sediment and reactive mat matrices in microcosms. The individual components required for the direct injection and reactive mat methods were then combined in column experiments to test them under groundwater- flow rates and contaminant concentrations observed in the field. Results showed that both direct injection and the reactive mat are promising remediation methods, although the success of direct injection likely would depend on adequately distributing and maintaining organic substrate throughout the wetland sediment in the seep

  15. Use and Evaluation of Psuedo-Geostationary Lightning Mapping Data within the 2010 Experimental Warning Program and GOES-R Proving Ground

    Science.gov (United States)

    Kuhlman, K. M.; Siewert, C.; Stano, G. T.; Bruning, E. C.; Kingfield, D.; Baranowski, B.

    2010-12-01

    The primary objective of the Experimental Warning Program (EWP) is to evaluate the accuracy and the operational utility of new science, technology, and products in a testbed setting in order to gain feedback for improvements prior to their potential implementation into National Weather Service (NWS) operations. A developmental product for the GOES-R Geostationary Lightning Mapper (GLM) was demonstrated during the Spring 2010 EWP as part of the GOES-R Proving Ground. This product was created using data from ground-based Lightning Mapping Array (LMA) networks sorted into flashes and displayed at the 8 km resolution expected with the GLM. During the EWP, forecasters were able to examine the lightning data in AWIPS in conjunction with radar and other multi-sensor products as part of their warning-decision process for both real-time and archive events. Forecasters were then asked to provide feedback through both online surveys following the event and discussion with lead scientists. In general, the PGLM products provided a strong support tool for the forecasters and helped increase forecaster confidence to warn or not warn on a storm. Forecasters viewed future GLM data as a “great tool” or a possible “mainstream product” for “situational awareness.” Multiple forecaster comments echoed the idea of using the GLM data as an additional tool to radar, particularly during the early stages of storm development. Suggestions were given regarding display of the data as well as for future product integration. This feedback will help shape the design of the products and educational tools concerning lightning data ahead of the availability of GOES-R data in the local NWS offices. In addition to the individual forecaster feedback, all warnings issued by the forecasters during the EWP have been scored (POD, FAR) and compared with the official NWS warnings to determine what type of influence the GOES-R products may have had on the warning decision process as well as on

  16. Design and Performance of an Enhanced Bioremediation Pilot Test in a Tidal Wetland Seep, West Branch Canal Creek, Aberdeen Proving Ground, Maryland

    Science.gov (United States)

    Majcher, Emily H.; Lorah, Michelle M.; Phelan, Daniel J.; McGinty, Angela L.

    2009-01-01

    Because of a lack of available in situ remediation methods for sensitive wetland environments where contaminated groundwater discharges, the U.S. Geological Survey, in cooperation with the U.S. Army Garrison, Aberdeen Proving Ground, Maryland, conceived, designed, and pilot tested a permeable reactive mat that can be placed horizontally at the groundwater/surface-water interface. Development of the reactive mat was part of an enhanced bioremediation study in a tidal wetland area along West Branch Canal Creek at Aberdeen Proving Ground, where localized areas of preferential discharge (seeps) transport groundwater contaminated with carbon tetrachloride, chloroform, tetrachloroethene, trichloroethene, and 1,1,2,2-tetrachloroethane from the Canal Creek aquifer to land surface. The reactive mat consisted of a mixture of commercially available organic- and nutrient-rich peat and compost that was bioaugmented with a dechlorinating microbial consortium, WBC-2, developed for this study. Due to elevated chlorinated methane concentrations in the pilot test site, a layer of zero-valent iron mixed with the peat and compost was added at the base of the reactive mat to promote simultaneous abiotic and biotic degradation. The reactive mat for the pilot test area was designed to optimize chlorinated volatile organic compound degradation efficiency without altering the geotechnical and hydraulic characteristics, or creating undesirable water quality in the surrounding wetland area, which is referred to in this report as achieving geotechnical, hydraulic, and water-quality compatibility. Optimization of degradation efficiency was achieved through the selection of a sustainable organic reactive matrix, electron donor, and bioaugmentation method. Consideration of geotechnical compatibility through design calculations of bearing capacity, settlement, and geotextile selection showed that a 2- to 3-feet tolerable thickness of the mat was possible, with 0.17 feet settlement predicted for

  17. Proceedings of the 1990 Scientific Conference on Obscuration and Aerosol Research Held in Aberdeen Proving Ground, Maryland on 25 - 28 June 1990

    Science.gov (United States)

    1991-06-01

    Using Electrodynamic Traps", Department of Chemistry, University of British Colombia , Vancouver, British Colombia , June 18, 1990. H) W. B. Whitten and...SMCCR- RSC -P/A. Brozena APG, MD 21010 423 CAMPILLO, ANTHONY COHOON, DAVID (202) 767-2057 (215) 436-2641 Naval Research Lab West Chester University ATTN

  18. Technology Description Sheets form the AMC 1990 Technology Expo Held in Aberdeen Proving Ground, Maryland on 1-4 October 1990

    Science.gov (United States)

    1990-10-04

    contact Director U S Army Harry Diamond Laboratories Attn SLCHD-NW 9S, Mark Caruso 2800 Powder Mill Road Adelph MD 20783 1974-2290DNS 290.2290 or (301) 394...nuclear threat involves initial nuclear radiation (INR) which consists of ncutrons and gamma radiation. INR is very penetrating. Neutrons can easily

  19. 3-D Waveguide Effects of Topographical Structural Variation on Full Waveform Propagation: 3-D Finite Difference Modeling Comparisons with Field Data From Yuma Proving Ground, Arizona

    Science.gov (United States)

    Anderson, T. S.; Miller, R.; Greenfield, R.; Fisk, D.

    2002-12-01

    The propagation of seismic waves through regions of complex topography is not thoroughly understood. Surface waves, are of particular interest, as they are large in amplitude and can characterize the source depth, magnitude, and frequency content. The amplitude and frequency content of seismic waves that propagate in regions with large topographical variations are affected by both the scattering and blockage of the wave energy. The ability to predict the 3-d scattering due to topography will improve the understanding of both regional scale surface wave magnitudes, and refine surface wave discriminants as well as at the local scale (Smart Weapons Test Range, Yuma Proving Ground, Arizona. The result of the KGS characterization study is a high-resolution 3-d model that is used in our seismic simulations. The velocities Vs, Vp are calculated by tomography and refraction, attenuation coefficients estimated from the surface wave and from p-waves and are provided in a model with attributes resolved in 3-d to 0.5 meters. In the present work, we present comparisons of synthetic data with seismic data collected at the Smart Weapons Test Range to benchmark the accuracy achieved in simulating 3-d wave propagation in the vicinity of a topographical anomaly (trench). Synthetic seismograms are generated using a 3-d 8th order staggered grid visco-elastic finite difference code that accounts for topography. The geologic model is based on the Yuma site characterization. The size of these calculations required use of the DoD High Performance Computers and parallelized code. Results are compared with field data. Preliminary results show an excellent match with field data using the 3-d fdtd technique.

  20. Background chemistry for chemical warfare agents and decontamination processes in support of delisting waste streams at the U.S. Army Dugway Proving Ground, Utah

    Energy Technology Data Exchange (ETDEWEB)

    Rosenblatt, D.H.; Small, M.J.; Kimmell, T.A.; Anderson, A.W.

    1996-04-01

    The State of Utah, Department of Environmental Quality (DEQ), Division of Solid and Hazardous Waste (DSHW), has declared residues resulting from the demilitarization, treatment, cleanup, and testing of military chemical agents to be hazardous wastes. These residues have been designated as corrosive, reactive, toxic, and acute hazardous (Hazardous Waste No. F999). The RCRA regulations (40 Code of Federal Regulations [CFR] 260-280), the Utah Administrative Code (R-315), and other state hazardous waste programs list specific wastes as hazardous but allow generators to petition the regulator to {open_quotes}delist,{close_quotes} if it can be demonstrated that such wastes are not hazardous. The U.S. Army Test and Evaluation Command (TECOM) believes that certain categories of F999 residues are not hazardous and has obtained assistance from Argonne National Laboratory (Argonne) to make the delisting demonstration. The objective of this project is to delist chemical agent decontaminated residues resulting from materials testing activities and to delist a remediation residue (e.g., contaminated soil). To delist these residues, it must be demonstrated that the residues (1) do not contain hazardous quantities of the listed agents; (2) do not contain hazardous quantities of constituents listed in 40 CFR Part 261, Appendix VIII; (3) do not exhibit other characteristics that could define the residues as hazardous; and (4) do not fail a series of acute toxicity tests. The first phase will focus on a subset of the F999 wastes generated at the U.S. Army Dugway Proving Ground (DPG), where the Army tests the effects of military chemical agents and agent-decontamination procedures on numerous military items. This effort is identified as Phase I of the Delisting Program. Subsequent phases will address other DPG chemical agent decontaminated residues and remediation wastes and similar residues at other installations.

  1. Application of ground penetrating radar for identification of washover deposits and other stratigraphic features: Assateague Island, MD

    Science.gov (United States)

    Zaremba, Nicholas; Smith, Christopher G.; Bernier, Julie C.; Forde, Arnell S.

    2016-01-01

    A combination of ground penetrating radar (GPR) data, core data, and aerial photographs were analyzed to better understand the evolution of two portions of Assateague Island, Maryland. The focus of the study was to investigate the applicability of using GPR data to image washover deposits in the stratigraphic record. High amplitude reflections observed in two shore-perpendicular GPR profiles were correlated to shallow ( photography. Additional sedimentological data are required to determine what role overwash played in the in-filling of these features.

  2. Stratigraphy and geophysical logs from a corehole drilled to bedrock at Robins Point, J-Field, Edgewood area, Aberdeen Proving Ground, Maryland

    Science.gov (United States)

    Powars, D.S.

    1997-01-01

    A continuous core was recovered from a 961-foot- deep stratigraphic corehole at Robins Point, located at the southeastern tip of the Gunpowder Neck Peninsula, Harford County, Maryland. A 2-inch- diameter ground-water-quality observation well was installed with the screen set at a depth of 392 to 402 feet (ft). Geophysical logs obtained from thecorehole include: natural gamma, multipoint normal resistivity (16-inch and 64-inch), 4-ft-guard focused resistivity, acoustic (sonic) velocity, and caliper. Pollen analysis of 34 samples provided relativestratigraphic ages. Lithologies encountered in ascending order (surface elevation 4 ft above mean sea level), include: 72.4 ft of weatheredmetamorphic rock and saprolie, 711.4 ft of lower and upper Cretaceous fluvio-deltaic deposits, and 145.9 ft of Pleistocene and 31.3 ft of Holocene(?) fluvial and estuarine deposits. Aquifers and confining units identified include, in descending order: 41.8 ft of surficial aquifer, 90.9 ft of upper paleochannel confining unit, 28.8 ft of paleochannel confined aquifer, 15.7 ft of lower paleochannel confining unit, 123.7 ft of Upper Patapsco aquifer, 44.6 ft of Upper Patapsco confining unit, 92.8 ft of Middle Patapsco aquifer, 57.3 ft of Lower Patapsco confining unit, 151.7 ft of Lower Patapsco aquifer, 115.4 ft of Potomac confining unit, 126.4 ft of Patuxent aquifer, an aquifer of 23.4 ft of saprolite, and 48.7 ft of weathered-rock/saprolite confining unit.

  3. The proving grounds: combat nursing in Vietnam.

    Science.gov (United States)

    Levasseur, Jeanne J

    2003-01-01

    The profession of nursing has been greatly influenced by war, and the heroic nature of the work of nursing is often emphasized during war. The purpose of this research was to examine the stories of nurses' experiences during combat in Vietnam and identify themes that would corroborate, refute, or expand prior historical research. A content analysis to determine recurrent themes was performed on 18 oral histories of military nurses who served in Vietnam that were previously collected and published. Analysis of these collections of oral histories was conducted, and thick quotes contextualize and substantiate the thematic claims. This research confirms the analysis of prior historical research on nursing in Vietnam by finding similar experiences recorded in oral histories and further claims that an authentic professional identity is often forged during the hardships and heroic opportunities of war.

  4. Additional Soil Evaluations at Yuma Proving Ground

    National Research Council Canada - National Science Library

    Kurtz, James

    1997-01-01

    .... These tests were performed for the Army Research Laboratory. The objectives of this effort were primarily to characterize the soil conditions, particularly moisture and dielectric permittivity, in support of anticipated unexploded ordnance (UXO...

  5. On Mathematical Proving

    Science.gov (United States)

    Stefaneas, Petros; Vandoulakis, Ioannis M.

    2015-12-01

    This paper outlines a logical representation of certain aspects of the process of mathematical proving that are important from the point of view of Artificial Intelligence. Our starting-point is the concept of proof-event or proving, introduced by Goguen, instead of the traditional concept of mathematical proof. The reason behind this choice is that in contrast to the traditional static concept of mathematical proof, proof-events are understood as processes, which enables their use in Artificial Intelligence in such contexts, in which problem-solving procedures and strategies are studied. We represent proof-events as problem-centered spatio-temporal processes by means of the language of the calculus of events, which captures adequately certain temporal aspects of proof-events (i.e. that they have history and form sequences of proof-events evolving in time). Further, we suggest a "loose" semantics for the proof-events, by means of Kolmogorov's calculus of problems. Finally, we expose the intented interpretations for our logical model from the fields of automated theorem-proving and Web-based collective proving.

  6. Cryptanalysis of MD2

    DEFF Research Database (Denmark)

    Knudsen, Lars Ramkilde; Mathiassen, John Erik; Muller, Frédéric

    2010-01-01

    This paper considers the hash function MD2 which was developed by Ron Rivest in 1989. Despite its age, MD2 has withstood cryptanalytic attacks until recently. This paper contains the state-of-the-art cryptanalytic results on MD2, in particular collision and preimage attacks on the full hash funct...

  7. Injector MD Days 2017

    CERN Document Server

    Rumolo, G

    2017-01-01

    The Injector Machine Development (MD) days 2017 were held on 23-24 March, 2017, at CERN with thefollowing main goals:Give a chance to the MD users to present their results and show the relevant progress made in 2016 onseveral fronts.Provide the MD users and the Operation (OP) crews with a general overview on the outcome and theimpact of all ongoing MD activities.Identify the open questions and consequently define - with priorities - a list of machine studies in theinjectors for 2017 (covering the operational beams, LHC Injectors Upgrade, High Luminosity LHC,Physics Beyond Colliders, other projects).Create the opportunity to collect and document the highlights of the 2016 MDs and define the perspectivesfor 2017.Discuss how to make best use of the MD time, in particular let the main MD user express their wishesand see whether/how OP teams can contribute to their fulfilment.

  8. Md Maidul Islam

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences. Md Maidul Islam. Articles written in Journal of Chemical Sciences. Volume 122 Issue 2 March 2010 pp 247-257 Full Papers. DNA minor groove binding of small molecules: Experimental and computational evidence · Prateek Pandya Md Maidul Islam G Suresh Kumar B ...

  9. Interactive Theorem Proving and Verification

    Indian Academy of Sciences (India)

    Research in the area of automated reasoning is largely concentrated around two major themes – Automated Theorem Proving and Interactive Theorem Proving. The goal of Auto- mated Theorem Proving, as the name suggests, is to try to prove a wide range of mathematical theorems using a computer in an automatic ...

  10. MD plans in 2012

    OpenAIRE

    Assmann, R

    2012-01-01

    Machine development sessions were performed in 2011 during dedicated slots of beam time. These MD studies were scheduled and planned in detail well before, reflecting the agreed priorities: further optimizing machine performance, exploring beam parameters beyond design targets, assessing machine limitations, testing new concepts and machine settings. The MD's in 2012 will build on the successful 2011 experience. The proposed priorities are discussed. A particular emphasis is put on how to bes...

  11. Anaerobic degradation of 1,1,2,2-tetrachloroethane and association with microbial communities in a freshwater tidal wetland, Aberdeen Proving Ground, Maryland : laboratory experiments and comparisons to field data

    Science.gov (United States)

    Lorah, Michelle M.; Voytek, Mary A.; Kirshtein, Julie D.; Jones, Elizabeth J.

    2003-01-01

    Defining biodegradation rates and processes is a critical part of assessing the feasibility of monitored natural attenuation as a remediation method for ground water containing organic contaminants. During 1998?2001, the U.S. Geological Survey conducted a microbial study at a freshwater tidal wetland along the West Branch Canal Creek, Aberdeen Proving Ground, Maryland, as part of an investigation of natural attenuation of chlorinated volatile organic compounds (VOCs) in the wetland sediments. Geochemical analyses and molecular biology techniques were used to investigate factors controlling anaerobic degradation of 1,1,2,2-tetrachloroethane (TeCA), and to characterize the microbial communities that potentially are important in its degradation. Rapid TeCA and daughter product degradation observed in laboratory experiments and estimated with field data confirm that natural attenuation is a feasible remediation method at this site. The diverse microbial community that seems to be involved in TeCA degradation in the wetland sediments varies with changing spatial and seasonal conditions, allowing continued effective natural attenuation throughout the year. Rates of TeCA degradation in anaerobic microcosm experiments conducted with wetland sediment collected from two different sites (WB23 and WB30) and during three different seasons (March?April 1999, July?August 1999, and October?November 2000) showed little spatial variability but high seasonal variability. Initial first-order degradation rate constants for TeCA ranged from 0.10?0.01 to 0.16?0.05 per day (half-lives of 4.3 to 6.9 days) for March?April 1999 and October?November 2000 microcosms incubated at 19 degrees Celsius, whereas lower rate constants of 0 ? 0.03 and 0.06 ? 0.03 per day were obtained in July?August 1999 microcosms incubated at 19 degrees Celsius. Microbial community profiles showed that low microbial biomass and microbial diversity in the summer, possibly due to competition for nutrients by the

  12. Potential Discrepancies in Radar Signature Predictions for Ground Vehicles

    Science.gov (United States)

    2004-06-01

    class of ground targets of interest for millimeter (MSRC) at Aberdeen Proving Ground (AIG), MD. wave radar applications . We summarize the unclassified...radar rays/wavelength in the shooting and bouncing ray ( SBR ) signatures. method. This represents a typical time for far-field calculations and the actual...eueteesuiu utibuc otiuin.We The virtual models include material descriptions but reduce these spurious multi-bounce contributions. When we remove the rubber

  13. Geometric inequalities methods of proving

    CERN Document Server

    Sedrakyan, Hayk

    2017-01-01

    This unique collection of new and classical problems provides full coverage of geometric inequalities. Many of the 1,000 exercises are presented with detailed author-prepared-solutions, developing creativity and an arsenal of new approaches for solving mathematical problems. This book can serve teachers, high-school students, and mathematical competitors. It may also be used as supplemental reading, providing readers with new and classical methods for proving geometric inequalities. .

  14. ADT fast losses MD

    CERN Document Server

    Priebe, A; Dehning, B; Redaelli, S; Salvachua Ferrando, BM; Sapinski, M; Solfaroli Camillocci, M; Valuch, D

    2013-01-01

    The fast beam losses in the order of 1 ms are expected to be a potential major luminosity limitation for higher beam energies after the LHC long shutdown (LS1). Therefore a Quench Test is planned in the winter 2013 to estimate the quench limit in this timescale and revise the current models. This experiment was devoted to determination the LHC Transverse Damper (ADT) as a system for fast losses induction. A non-standard operation of the ADT was used to develop the beam oscillation instead of suppressing them. The sign flip method had allowed us to create the fast losses within several LHC turns at 450 GeV during the previous test (26th March 2012). Thus, the ADT could be potentially used for the studies of the UFO ("Unidentied Falling Object") impact on the cold magnets. Verification of the system capability and investigations of the disturbed beam properties were the main objectives of this MD. During the experiment, the pilot bunches of proton beam were excited independently in the horizontal and vertical ...

  15. A Cyber Proving Ground: The Search for Cyber Genius

    Science.gov (United States)

    2010-01-01

    medium but also the message.15 Media theorist Marshall McLuhan suggested that advanced technological com- munication mediums, such as the Internet or...telecommunication systems, have evolved into their own messages to share with the world. Furthermore, McLuhan the- orized that evolutions in

  16. Pacific Proving Grounds radioisotope imprint in the Philippine Sea sediments

    DEFF Research Database (Denmark)

    Pittauer, Daniela; Roos, Per; Qiao, Jixin

    2017-01-01

    Radionuclide concentrations were studied in sediment cores taken at the continental slope of the Philippine Sea off Mindanao Island in the equatorial Western Pacific. High resolution deposition records of anthropogenic radionuclides were collected at this site. Excess 210Pb together with excess 228...

  17. ASTAMIDS minefield detection performance at Aberdeen Proving Ground test site

    Science.gov (United States)

    Maksymonko, George B.; Breiter, Karin

    1997-07-01

    The airborne standoff minefield detection systems (ASTAMIDS) is an airborne imaging system designed for deployment as a modular mission payload on an unmanned aerial vehicle and capable of detecting surface and buried anti-tank mines under all-weather, day/night conditions. Its primary mission is to support a forward maneuver unit with real time intelligence regarding the existence and extent of minefields in their operational area. The ASTAMIDS development effort currently consists of two parallel technical approaches, passive thermal IR sensor technology in one case and an active multi-channel sensor utilizing passive thermal IR coregistered with a near IR laser polarization data for the other case. The minefield detection capability of this system is a result of signal processing of image data. Due to the large quantities of data generated by an imaging sensor even at modest speeds of an unmanned aerial vehicle, manual exploitation of this data is not feasible in a real time tactical environment and therefore computer aided target feature extraction is a necessity to provide detection cues. Our development efforts over the past several years have concentrated on mine and minefield detection algorithms, the hardware necessary to execute these algorithms in real time, and the tools with which to measure detection performance.

  18. Hydrogeology of the Canal Creek area, Aberdeen Proving Ground, Maryland

    Science.gov (United States)

    Oliveros, J.P.; Vroblesky, D.A.

    1989-01-01

    Geologic and borehole geophysical logs made at 77 sites show that the hydrogeologic framework of the study area consists of a sequence of unconsolidated sediments typical of the Coastal Plain of Maryland. Three aquifers and two confining units were delineated within the study area. From the surface down, they are: (1) the surficial aquifer; (2) the upper confining unit; (3) the Canal Creek aquifer; (4) the lower confining unit; and (5) the lower confined aquifer. The aquifer materials range from fine sand to coarse sand and gravel. Clay lenses were commonly found interfingered with the sand, isolating parts of the aquifers. All the units are continuous throughout the study area except for the upper confining unit, which crops out within the study area but is absent in updip outcrops. The unit also is absent within a Pleistocene paleochannel, where it has been eroded. The surficial and Canal Creek aquifers are hydraulically connected where the upper confining unit is absent, and a substantial amount of groundwater may flow between the two aquifers. Currently, no pumping stresses are known to affect the aquifers within the study area. Under current conditions, downward vertical hydraulic gradients prevail at topographic highs, and upward gradients typically prevail near surface-water bodies. Regionally, the direction of groundwater flow in the confined aquifers is to the east and southeast. Significant water level fluctuations correspond with seasonal variations in rainfall, and minor daily fluctuations reflect tidal cycles. (USGS)

  19. Yuma Proving Ground GEM-3-E Data Collection

    Science.gov (United States)

    2007-11-01

    severe desert environment. The soils in this region generally consist of calcium carbonate materials that tend to cement together in the soil, producing...desert region may have a horizon of calcium carbonates that tend to cement together in the soil, producing hard layers in the subsurface. The...determine the magnitude of the lag. The instrument was placed on a ferrite core calibration item (see Figure 8) with the DGPS streaming position data

  20. Edgewood Area - Aberdeen Proving Ground Five-Year Review

    Science.gov (United States)

    2008-10-01

    STORAGE AREA-CL 12 IP 1995 EAOE16 M-FLD MINE-FLD/P-TYPE BLDG. STO AREA C16 IP EAOE19 FORT HOYLE TRAINING AREA-CLUSTER 19 IP 1994 1997 EAOE19 FORT HOYLE ...the presence of residual white phosphorus (WP). Due to the excavation not being backfilled, a 3.6-acre pond was created. Based on historical...The removal created a 3.6-acre pond where the excavation penetrated the water table. 2.3.2 Land and Resource Use Old O-Field, located in the

  1. Demonstration of MPV Sensor at Yuma Proving Ground, AZ

    Science.gov (United States)

    2011-06-01

    data quality is similar – the receiver coils essentially behave like point receivers. Balsa wood was used instead of solid plastic; - Wood and...directly related to the acreage to be surveyed as well as the difficulty of the terrain (steep, rocky, very uneven, and wooded terrain will take...maneuverable and sturdier sensor head. Figure 27: Original MPV sensor head design (head weight: 23 lbs). The original design was built out of wood

  2. Proving allelopathy in crop-weed interactions

    Science.gov (United States)

    Allelopathy (plant/plant chemical warfare) is difficult to prove, especially when competition for resources is the dominant component of plant/plant interference (interference = allelopathy +competition). This paper describes experimental approaches for proving allelopathy and points out common pit...

  3. Symbolic logic and mechanical theorem proving

    CERN Document Server

    Chang, Chin-Liang

    1969-01-01

    This book contains an introduction to symbolic logic and a thorough discussion of mechanical theorem proving and its applications. The book consists of three major parts. Chapters 2 and 3 constitute an introduction to symbolic logic. Chapters 4-9 introduce several techniques in mechanical theorem proving, and Chapters 10 an 11 show how theorem proving can be applied to various areas such as question answering, problem solving, program analysis, and program synthesis.

  4. LHC MD 1279: Bunch Flattening in Physics

    CERN Document Server

    AUTHOR|(CDS)2073675; Baudrenghien, Philippe; Esteban Muller, Juan; Shaposhnikova, Elena; CERN. Geneva. ATS Department

    2017-01-01

    Vertex reconstruction is not accurate enough for LHCb when the bunch length in physics shrinks below about 0.9 ns. The end-of-fill MD studies presented here proved that bunch flattening using sinusoidal RF modulation is a loss-free method to increase the r.m.s. bunch length and flatten the bunch profile. Furthermore, the optimum modulation parameters to be used in physics have been identified. Subsequently, bunch flattening in physics was used operationally with a modulation frequency of 98.75 % of the central synchrotron frequency and 0.6 modulation amplitude, resulting in a 150-200 ps increase in the BQM-measured bunch length. A ‘mid-of-fill’ test at arrival to flat top revealed that also the bunch distribution created by the controlled emittance blow-up during the ramp is affected when bunch flattening is applied. The measurements took place on 17th June and the 4th, 7th and 22nd July 2016. Operational cases are shown as well.

  5. APTE: An Algorithm for Proving Trace Equivalence

    OpenAIRE

    Cheval, Vincent

    2014-01-01

    This paper presents APTE, a new tool for automatically proving the security of cryptographic protocols. It focuses on proving trace equivalence between processes, which is crucial for specifying privacy type properties such as anonymity and unlinkability.\\ud \\ud The tool can handle protocols expressed in a calculus similar to the applied-pi calculus, which allows us to capture most existing protocols that rely on classical cryptographic primitives. In particular, APTE handles private channels...

  6. MD210 Note: Creation of Hollow Bunches in the PSB

    CERN Document Server

    Oeftiger, Adrian; Findlay, Alan James; Hancock, Steven; Rumolo, Giovanni; CERN. Geneva. ATS Department

    2016-01-01

    MD210 aims for the creation of longitudinally hollow bunches in the CERN PS Booster. The first three sessions have been carried out using the radial loop feedback system in order to drive the beam on a dipolar parametric resonance (instead of the phase loop). It has been found that the damping by the phase loop inhibits the excitation of the resonance to a major extent. The hollow distributions generated under these circumstances fail to reach a satisfying bunching factor. Nonetheless, proving the principally successful application of this technique to the PS Booster promises good results once the phase loop system supports trim functions. The approach, actions and detailed results of the first three MD sessions are presented in this paper.

  7. Proving program inclusion using Hoare's logic

    NARCIS (Netherlands)

    Bergstra, J.A.; Klop, J.W.

    1984-01-01

    We explore conservative refinements of specifications. These form a quite appropriate framework for a proof theory for program inclusion based on a proof theory for program correctness. We propose two formalized proof methods for program inclusion and prove these to be sound. Both methods are

  8. Affect, Behavioural Schemas and the Proving Process

    Science.gov (United States)

    Selden, Annie; McKee, Kerry; Selden, John

    2010-01-01

    In this largely theoretical article, we discuss the relation between a kind of affect, behavioural schemas and aspects of the proving process. We begin with affect as described in the mathematics education literature, but soon narrow our focus to a particular kind of affect--nonemotional cognitive feelings. We then mention the position of feelings…

  9. Proving a Result in Combinatorics using Equations

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 9; Issue 2. Proving a Result in Combinatorics using Equations. V Rajesh. Classroom Volume 9 Issue 2 February 2004 pp 85-87. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/009/02/0085-0087. Keywords.

  10. First thoughts on MD priorities for 2012

    CERN Document Server

    Zimmermann, F; Assmann, R

    2012-01-01

    In 2012, 22 days of beam time will be allocated for LHC MDs. In this paper, after recalling the 2011 LHC MD experience, the MD rrequests for 2012 are reviewed. Three primary MD themes for 2012 can be identified: 1)pushing performance in 2012, 2)preparing for 2014/15, and 3)towards maximum luminosity. Example topics include emittance growth in collision or enhanced satellites for theme 1), 25 ns operation for 2), and ATS optics for 3). Structures lists of MD requests and topics for each theme as well as some initial thoughts on the MD priorities are presented. For certain topics, "start-of-fill MDs" are proposed in order to most efficiently use of the available beam time.

  11. On proving syntactic properties of CPS programs

    DEFF Research Database (Denmark)

    Danvy, Olivier; Dzafic, Belmina; Pfenning, Frank

    1999-01-01

    Higher-order program transformations raise new challenges for proving properties of their output, since they resist traditional, first-order proof techniques. In this work, we consider (1) the “one-pass” continuation-passing style (CPS) transformation, which is second-order, and (2) the occurrences...... of parameters of continuations in its output. To this end, we specify the one-pass CPS transformation relationally and we use the proof technique of logical relations....

  12. Automated theorem proving theory and practice

    CERN Document Server

    Newborn, Monty

    2001-01-01

    As the 21st century begins, the power of our magical new tool and partner, the computer, is increasing at an astonishing rate. Computers that perform billions of operations per second are now commonplace. Multiprocessors with thousands of little computers - relatively little! -can now carry out parallel computations and solve problems in seconds that only a few years ago took days or months. Chess-playing programs are on an even footing with the world's best players. IBM's Deep Blue defeated world champion Garry Kasparov in a match several years ago. Increasingly computers are expected to be more intelligent, to reason, to be able to draw conclusions from given facts, or abstractly, to prove theorems-the subject of this book. Specifically, this book is about two theorem-proving programs, THEO and HERBY. The first four chapters contain introductory material about automated theorem proving and the two programs. This includes material on the language used to express theorems, predicate calculus, and the rules of...

  13. Theorem Proving In Higher Order Logics

    Science.gov (United States)

    Carreno, Victor A. (Editor); Munoz, Cesar A.; Tahar, Sofiene

    2002-01-01

    The TPHOLs International Conference serves as a venue for the presentation of work in theorem proving in higher-order logics and related areas in deduction, formal specification, software and hardware verification, and other applications. Fourteen papers were submitted to Track B (Work in Progress), which are included in this volume. Authors of Track B papers gave short introductory talks that were followed by an open poster session. The FCM 2002 Workshop aimed to bring together researchers working on the formalisation of continuous mathematics in theorem proving systems with those needing such libraries for their applications. Many of the major higher order theorem proving systems now have a formalisation of the real numbers and various levels of real analysis support. This work is of interest in a number of application areas, such as formal methods development for hardware and software application and computer supported mathematics. The FCM 2002 consisted of three papers, presented by their authors at the workshop venue, and one invited talk.

  14. Has the Agrotherm method proved useful

    Energy Technology Data Exchange (ETDEWEB)

    Schikora, G.

    1982-03-19

    The author reports on the Agrotherm project. It was planned not to carry off the waste heat of power plants via conventional cooling towers but to use the heat for heating agricultural areas by conducting the hot waste water through pipes buried in the ground. One hopes to improve the yield by this measure.

  15. Interval logic. Proof theory and theorem proving

    DEFF Research Database (Denmark)

    Rasmussen, Thomas Marthedal

    2002-01-01

    of a direction of an interval, and present a sound and complete Hilbert proof system for it. Because of its generality, SIL can conveniently act as a general formalism in which other interval logics can be encoded. We develop proof theory for SIL including both a sequent calculus system and a labelled natural...... deduction system. We conduct theoretical investigations of the systems with respect to subformula properties, proof search, etc. The generic theorem proving system Isabelle is used as a framework for encoding both proof theoretical systems. We consider a number of examples/small case-studies and discuss...

  16. 75 FR 49481 - Procurement List; Additions and Deletion

    Science.gov (United States)

    2010-08-13

    ... (C4ISR), 4118 Susquehanna Avenue, Aberdeen Proving Ground, MD. NPA: The Chimes, Inc., Baltimore, MD. Contracting Activity: Dept of the Army, XR W6BA ACA, Aberdeen Proving Ground, Aberdeen Proving Ground, MD...

  17. Resolution methods in proving the program correctness

    Directory of Open Access Journals (Sweden)

    Markoski Branko

    2007-01-01

    Full Text Available Program testing determines whether its behavior matches the specification, and also how it behaves in different exploitation conditions. Proving of program correctness is reduced to finding a proof for assertion that given sequence of formulas represents derivation within a formal theory of special predicted calculus. A well-known variant of this conception is described: correctness based on programming logic rules. It is shown that programming logic rules may be used in automatic resolution procedure. Illustrative examples are given, realized in prolog-like LP-language (with no restrictions to Horn's clauses and without the final failure. Basic information on LP-language are also given. It has been shown how a Pascal-program is being executed in LP-system proffer.

  18. Theorem Proving in Intel Hardware Design

    Science.gov (United States)

    O'Leary, John

    2009-01-01

    For the past decade, a framework combining model checking (symbolic trajectory evaluation) and higher-order logic theorem proving has been in production use at Intel. Our tools and methodology have been used to formally verify execution cluster functionality (including floating-point operations) for a number of Intel products, including the Pentium(Registered TradeMark)4 and Core(TradeMark)i7 processors. Hardware verification in 2009 is much more challenging than it was in 1999 - today s CPU chip designs contain many processor cores and significant firmware content. This talk will attempt to distill the lessons learned over the past ten years, discuss how they apply to today s problems, outline some future directions.

  19. University of Texas M.D. Anderson Cancer Center

    Science.gov (United States)

    ... Videoconferencing Alumni Alumni Alumni Home Giving to the Education Fund Activities About MD Anderson About MD Anderson Home Facts & History Facts & History Facts & History Home Shared Governance Committee ...

  20. Valutazione economica dello studio PROVE-IT

    Directory of Open Access Journals (Sweden)

    Lorenzo G. Mantovani

    2007-10-01

    Full Text Available Introduction: the PROVE-IT (“Intensive versus moderate lipid lowering with statins after acute coronary syndromes” was a comparison of pravastatin 40 mg/die versus atorvastatin 80 mg/die in patients with an acute coronary syndrome (ACS. Aim: our aim was to investigate the economic consequence of high dose of atorvastatin vs usual-dose of pravastatin in Italian patients with a history of acute coronary syndrome. Methods: the analysis is conducted on the basis of clinical outcomes of the PROVE-IT study. We conducted a cost-effectiveness analysis, comparing high dose of atorvastatin (80 mg/die versus usual-dose of pravastatin (40 mg/die in the perspective of the Italian National Health Service. We identified and quantified medical costs: drug costs according to the Italian National Therapeutic Formulary and hospitalizations were quantified based on the Italian National Health Service tariffs (2006. Effects were measured in terms of mortality and morbidity reduction (number of deaths, life years gained and frequency of hospitalizations. We considered an observation period of 24 months. The costs borne after the first 12 months were discounted using an annual rate of 3%. We conducted one and multi-way sensitivity analyses on unit cost and effectiveness. We also conducted a threshold analysis. Results: the cost of pravastatin or atorvastatin therapy over the 2 years period amounted to approximately 1.3 millions euro and 870,000 euro per 1,000 patients respectively. Atorvastatin was more efficacious compared to pravastatin and the overall cost of care per 1,000 patients over 24 months of follow-up was estimated at 3.2 millions euro in the pravastatin and 2.5 millions euro in the atorvastatin group, resulting into a cost saving of about 700,000 euro that is 27% of total costs occurred in the pravastatin group. Discussion: this study demonstrates that high does atorvastatin treatment leads to a reduction of direct costs for the National Health System

  1. a Test to Prove Cloud Whitening THEORY!

    Science.gov (United States)

    Buttram, J. W.

    2011-12-01

    Climate science researchers believe our planet can possibly tolerate twice the present carbon dioxide levels with no upwards temperature change, IF we could increase the amount of energy reflected back out into space by about 2.0%. (c)Cloudtec basically alters a blend of seawater and applies heat derived from magma to it at a temperature exceeding 2,000 degrees F. The interaction of seawater and magma displaces the oxygen, causing the volume of water to vaporize and expand over 4,000 times - transforming billions of tons of seawater into thousands of cubic miles of white, maritime, stratocumulus clouds to reflect the incident Sun's rays back out into space. A 6 month test to prove Cloud Whitening Theory will cost 6 million dollars. (No profit added.) This study will enable everyone on the planet with a computer the transparency to use satellite imagery and check out for themselves - if and when Cloud Whitening is occurring. If Cloud Whitening Theory is validated, (c)Cloudtec's innovation can strategically create the clouds we need to reflect the Sun's rays back out into space and help neutralize the projected 3.6 degrees F rise in temperature. Based on reasonable calculations of anthropogenic global warming: this one move alone would be comparable to slashing global carbon dioxide emissions by over 60% over the next 40 years.

  2. MD2190: Q" Stabilization during injection

    CERN Document Server

    Schenk, Michael; Li, Kevin Shing Bruce; Malina, Lukas; Metral, Elias; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2018-01-01

    This MD is a follow-up study of MD1831, where single bunches were stabilized against impedance-driven instabilities at 6.5 TeV in the LHC with Q''. The goals are (i) to explore whether an amplitude detuning free Q'' knob can be implemented at injection energy, and (ii) whether Q'' can provide beam stability at injection, where the beams suffer mostly from electron cloud effects. Ideally, this would relax the use of the Landau octupoles and may help in preserving the beam quality by reducing dynamic aperture limitations originating from the octupoles. The MD has been split into two parts: First, optics corrections were put in place to minimize beta-beating and linear coupling introduced by the knobs. The corrections were achieved by means of orbit bumps and skew quadrupole knobs. Machine safety was then validated with loss maps. While the betatron loss maps were approved, the off-momentum maps showed a priori unexpected losses in several arcs and the MD was stopped at this point for reasons of machine protecti...

  3. Correspondence Dated April 17, 1848, from Charles T. Jackson, MD, to John Snow, MD.

    Science.gov (United States)

    Haridas, Rajesh P; Bause, George S

    2017-07-01

    A previously unpublished four-page letter from Charles T. Jackson, MD, to John Snow, MD, was acquired in December 2016 by the Wood Library-Museum of Anesthesiology, Schaumburg, IL. The letter may be a draft or a copy of the letter which may have been sent to Snow in 1848. Jackson's letter to Snow does not reveal any significant new insight into the controversy over the discovery of etherization. A hitherto unknown meeting of Jackson's former chemistry student, Joseph Peabody, and John Snow, MD, was revealed in the letter. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. MD1271: Effect of low frequency noise on the evolution of the emittance and halo population

    CERN Document Server

    Fitterer, Miriam; Valishev, Alexander; Bruce, Roderik; Hofle, Wolfgang; Hostettler, Michi; Papadopoulou, Parthena Stefania; Papotti, Giulia; Papaphilippou, Yannis; Pellegrini, Dario; Trad, Georges; Valuch, Daniel; Valentino, Gianluca; Wagner, Joschka; Cai, Xu; CERN. Geneva. ATS Department

    2018-01-01

    For the High Luminosity upgrade the β* in IR1 and IR5 will be further reduced compared to the current LHC. As the β* decreases the β-functions in the inner triplet (IT) increase resulting in a higher sensitivity of the HL-LHC to ground motion in the IT region or to increases of the low frequency noise. Noise can in general lead to emittance growth and higher halo population and diffusion rate. However, it is usually assumed in the literature that only frequencies close to the betatron frequencies and sidebands have an effect on the emittance and tail population. To test this theory, an MD was carried out to observe if also low frequency noise can lead to emittance growth and stronger halo population and diffusion. This MD conducted on 24.08.2016 follows a previous MD on 05.11.2015/06.11.2015

  5. Exploring intentions of physician-scientist trainees: factors influencing MD and MD/PhD interest in research careers.

    Science.gov (United States)

    Kwan, Jennifer M; Daye, Dania; Schmidt, Mary Lou; Conlon, Claudia Morrissey; Kim, Hajwa; Gaonkar, Bilwaj; Payne, Aimee S; Riddle, Megan; Madera, Sharline; Adami, Alexander J; Winter, Kate Quinn

    2017-07-11

    Prior studies have described the career paths of physician-scientist candidates after graduation, but the factors that influence career choices at the candidate stage remain unclear. Additionally, previous work has focused on MD/PhDs, despite many physician-scientists being MDs. This study sought to identify career sector intentions, important factors in career selection, and experienced and predicted obstacles to career success that influence the career choices of MD candidates, MD candidates with research-intense career intentions (MD-RI), and MD/PhD candidates. A 70-question survey was administered to students at 5 academic medical centers with Medical Scientist Training Programs (MSTPs) and Clinical and Translational Science Awards (CTSA) from the NIH. Data were analyzed using bivariate or multivariate analyses. More MD/PhD and MD-RI candidates anticipated or had experienced obstacles related to balancing academic and family responsibilities and to balancing clinical, research, and education responsibilities, whereas more MD candidates indicated experienced and predicted obstacles related to loan repayment. MD/PhD candidates expressed higher interest in basic and translational research compared to MD-RI candidates, who indicated more interest in clinical research. Overall, MD-RI candidates displayed a profile distinct from both MD/PhD and MD candidates. MD/PhD and MD-RI candidates experience obstacles that influence their intentions to pursue academic medical careers from the earliest training stage, obstacles which differ from those of their MD peers. The differences between the aspirations of and challenges facing MD, MD-RI and MD/PhD candidates present opportunities for training programs to target curricula and support services to ensure the career development of successful physician-scientists.

  6. MD on UFOs at MKIs and MKQs

    CERN Document Server

    Baer, T; Bartmann, W; Bracco, C; Carlier, E; Dehning, B; Garrel, N; Goddard, B; Jackson, S; Jimenez, M; Kain, V; Mertens, V; Misiowiec, M; Nordt, A; Papotti, G; Uythoven, J; Wenninger, J; Zerlauth, M; Zamantzas, C; Zimmermann, F

    2012-01-01

    UFOs ("Unidentified Falling Objects") are expected to be one of the major known performance limitation of the LHC. In this MD, the production mechanism and the dynamics of UFOs at the injection kicker magnets (MKIs) and the tune kicker magnets (MKQs) were studied. This was done by pulsing the MKIs and MKQs on a gap in the partly filled machine. During the MD, in total 58 UFO-type beam loss patterns were observed directly after pulsing the MKIs. None were observed after pulsing the MKQs, which provides important input for possible mitigation strategies. The temporal and spatial distribution of the UFO events could be determined by using a dedicated BLM Study Buffer, the implications for the UFO dynamics are discussed.

  7. The MD and MS degrees in Britain.

    OpenAIRE

    McManus, I. C.

    1988-01-01

    Higher medical degrees--MD and MS--have been awarded at an increased rate since 1980, owing partly to increased numbers of medical graduates and partly to greater career competition. The pass rate has not changed since 1965. Regulations at various universities show substantial differences, particularly in the use of viva voce examinations for failed candidates, in permissible subject matter, and in allowing the submission of previously published papers. As these degrees are important for care...

  8. 33 CFR 334.730 - Waters of Santa Rosa Sound and Gulf of Mexico adjacent to Santa Rosa Island, Air Force Proving...

    Science.gov (United States)

    2010-07-01

    ... Gulf of Mexico adjacent to Santa Rosa Island, Air Force Proving Ground Command, Eglin Air Force Base... Sound and Gulf of Mexico adjacent to Santa Rosa Island, Air Force Proving Ground Command, Eglin Air... regulations. (1) Experimental test operations will be conducted by the U.S. Air Force within the prohibited...

  9. 77 FR 5201 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Science.gov (United States)

    2012-02-02

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Bear Creek, Dundalk, MD... across Bear Creek, mile 3.4, between Dundalk and Sparrows Point, MD. The proposed change will alter the... Avenue across Bear Creek, mile 3.4 between Dundalk and Sparrows Point, MD. This change would require the...

  10. 77 FR 73967 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Science.gov (United States)

    2012-12-12

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Bear Creek, Dundalk, MD... highway bridge at Wise Avenue across Bear Creek, mile 3.4, between Dundalk and Sparrows Point, MD. The... Regulation; Bear Creek, Dundalk, MD'' in the Federal Register (77 FR 5201). The rulemaking concerned would...

  11. Gordon Fullerton in PCA (MD-11) Simulator

    Science.gov (United States)

    1998-01-01

    NASA research pilot Gordon Fullerton 'flying' in the MD-11 simulator during the Propulsion Controlled Aircraft (PCA) project. This investigation grew out of the crash of a DC-10 airliner on July 19, 1989, following an explosion in the rear engine which caused the loss of all manual flight controls. The flight crew attempted to control the airliner using only the thrust from the two remaining engines. Although the DC-10 crashed during the landing attempt, 184 of the 296 passengers and crew aboard survived. The PCA effort at the Dryden Flight Research Center grew out of the crash, and attempted to develop a means to successfully land an aircraft using only engine thrust. After more than five years of work, on August 29, 1995, Gordon Fullerton made the first PCA touchdown aboard an MD-11 airliner (a later version of the DC-10). The concept was further refined over the years that followed this first landing. Simulators were essential ingredients of the PCA development process. The feasibility of the concept was first tested with an F-15 simulator, then the results of actual flight tests in an F-15 were incorporated back into the simulator. Additional simulations were run on the Boeing 720 airliner simulator used in the Controlled Impact Demonstration project. After the MD-11 test landings, Boeing 747 and 757 simulators tested a wide range of possible situations. Simulations even helped develop a method of landing an airliner if it lost its complete hydraulic system as well as a wing engine, by transferring fuel to shift the center of gravity toward the working engine. The most extreme procedure was undertaken in a 747 simulator. The aircraft simulated the loss of the hydraulic system at 35,000 feet and rolled upside down. Then, the PCA mode was engaged, the airliner righted itself, leveled its wings, and made an approach nearly identical to that of a normal auto landing.

  12. MD Test of a Ballistic Optics

    CERN Document Server

    Garcia-Tabares Valdivieso, Ana; Salvachua Ferrando, Belen Maria; Skowronski, Piotr Krzysztof; Solfaroli Camillocci, Matteo; Tomas Garcia, Rogelio; Wenninger, Jorg; Coello De Portugal - Martinez Vazquez, Jaime Maria; CERN. Geneva. ATS Department

    2016-01-01

    The ballistic optics is designed to improve the understanding of optical errors and BPM systematic effects in the critical triplet region. The particularity of that optics is that the triplet is switched off, effectively transforming the triplets on both sides of IR1 and IR5 into drift spaces. Advantage can be taken from that fact to localize better errors in the Q4-Q5-triplet region. During this MD this new optics was tested for the first time at injection with beam 2.

  13. LHC MD 2042: Persistent Injection Oscillations

    CERN Document Server

    Karpov, Ivan; Argyropoulos, Theodoros; Baudrenghien, Philippe; Chapochnikova, Elena; Timko, Helga; CERN. Geneva. ATS Department

    2018-01-01

    This MD note summarizes the measurements performed to study persistent longitudinal oscillations after injection into the LHC. It was found that they build up due to mismatch, and can lead to particle losses and uncontrolled bunch lengthening. For the first time, profile measurements and ObsBox data acquisitions were triggered at injection to obtain first-turn data. The measurements took place on 16th September 2017 between 14:30 and 19:30, and between 27th November 2017 20:00 and 28th November 2017 04:00.

  14. The MD and MS degrees in Britain.

    Science.gov (United States)

    McManus, I C

    1988-07-09

    Higher medical degrees--MD and MS--have been awarded at an increased rate since 1980, owing partly to increased numbers of medical graduates and partly to greater career competition. The pass rate has not changed since 1965. Regulations at various universities show substantial differences, particularly in the use of viva voce examinations for failed candidates, in permissible subject matter, and in allowing the submission of previously published papers. As these degrees are important for careers, and are registrable by the General Medical Council, it is suggested that it should issue minimal standards to be observed by all universities.

  15. 33 CFR 334.180 - Patuxent River, Md.; restricted areas, U.S. Naval Air Test Center, Patuxent River, Md.

    Science.gov (United States)

    2010-07-01

    ... areas, U.S. Naval Air Test Center, Patuxent River, Md. 334.180 Section 334.180 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.180 Patuxent River, Md.; restricted areas, U.S. Naval Air Test Center, Patuxent River, Md...

  16. Screening of UV-B-induced genes from apple peels by SSH: possible involvement of MdCOP1-mediated signaling cascade genes in anthocyanin accumulation.

    Science.gov (United States)

    Peng, Ting; Saito, Takanori; Honda, Chikako; Ban, Yusuke; Kondo, Satoru; Liu, Ji-Hong; Hatsuyama, Yoshimichi; Moriguchi, Takaya

    2013-07-01

    Suppression subtractive hybridization (SSH) was employed to identify candidate genes involved in red coloration in apple peel with the ultraviolet (UV)-B-treated 'Mutsu'. After reverse Northern blotting verification, nearly 80 clones were successfully sequenced. Large portions of the expressed sequence tags (ESTs) are well characterized anthocyanin biosynthesis-related genes, such as chalcone synthase (11A5), flavonol synthase (12F3), anthocyanidin synthase (11H5) and UDP-glycosyl transferase (14A12) whose presence proved the success of SSH. Eight ESTs were selected for quantitative real-time polymerase chain reaction analysis and their expressions were all elevated in 'Induction', further confirming the reliability of the SSH library. One EST, 11F4 (CONSTITUTIVE PHOTOMORPHOGENIC 1: COP1) with putative function in light signal relay was further analyzed in 'Mutsu' and 'Tsugaru', along with MdHY5 (ELONGATED HYPOCOTYL 5: the downstream target of COP1), MdMYB22 (a possible flavonol-specific activator under the regulation of HY5, belonging to the SG7/PRODUCTION OF FLAVONOL GLYCOSIDES family) and MdMYBA. Results showed that MdCOP1, MdHY5, MdMYB22 and MdMYBA were all UV-B inducible genes and anthocyanin accumulation occurred after their increased expressions. Moreover, their expressions and anthocyanin content were enhanced under UV-B plus 17°C treatment. The presence of G box, a known consensus binding site of HY5, in the MdMYBA promoter region implicated that it could be regulated by MdHY5, which was verified by the result of the yeast one-hybrid analysis. Our data suggested that UV-B irradiation would induce the utmost upstream light signaling factor, MdCOP1, which activates MdHY5 signaling by binding to the promoter regions of MdMYBs, and finally leads to the red coloration of apple peels. Copyright © Physiologia Plantarum 2012.

  17. Information Management for Installation Restoration with Focus on Aberdeen Proving Ground, Maryland

    Science.gov (United States)

    1993-08-01

    would be identi- fied as an error during the data QA check. On the other hand, a typographi - cal error such as entering ൜" instead of 薘" ft for...input. This menu -driven, interacting program checks data as they are entered for compati- bility with the IRDMIS system. This is the same program used by...generated from reports written from IRDMIS. Standard reports exist in the IRDMIS IR menu , but tailored reports can also be written, as discussed in Part

  18. An Archeological Overview and Management Plan for the Dugway Proving Ground.

    Science.gov (United States)

    1984-03-29

    kangaroo rats, gophers, and other rodents. Rodent species composition varies between plant communities (Vest 1962), but carnivores and omnivores range more...conducted in the fall and winter, when the fur and meat was at prime. Gophers, an abundant source of food, were trapped or flooded out of their holes...sometimes located in the center with a smokehole at the top. Household goods consisted of mano and metates used for grinding seeds, insects, meat

  19. Historic American Landscapes Survey: Arco Naval Proving Ground (Idaho National Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    Olson, Christina [Idaho National Lab. (INL), Idaho Falls, ID (United States); Holmer, Marie [Idaho National Lab. (INL), Idaho Falls, ID (United States); Gilbert, Hollie [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-07-01

    Based on historical evaluations in 1993 and 1997, historians determined that the then-remaining Arco NPG structures were significant to the nation’s history through their association with World War II . Through ensuing discussions with the SHPO, it was further determined that the infrastructure and associated landscape were also significant. According to provisions of INL’s Cultural Resource Management Plan (CRMP) as legitimized through a 2004 Programmatic Agreement between DOE-ID, the Idaho State Historic Preservation Office (SHPO), and Advisory Council on Historic Preservation (ACHP) historians identified the World War II structures as DOE “Signature Properties”. As defined by DOE-HQ, Signature Properties “denote its [DOE’s] most historically important properties across the complex…and/or those properties that are viewed as having tourism potential.” The INL is a secure site and the INL land and structures are not accessible to the public and, therefore have no “tourism potential”. Although DOE-ID actively sought other uses for the vacant, unused buildings, none were identified and the buildings present safety and health concerns. A condition assessment found lead based paint, asbestos, rodent infestation/droppings, small animal carcasses, mold, and, in CF-633, areas of radiological contamination. In early 2013, DOE-ID notified the Idaho SHPO, ACHP, and, as required by the INL CRMP and PA, DOE-Headquarters Federal Preservation Officer, of their intent to demolish the vacant buildings (CF-606, CF-607, CF-613, CF-632, and CF-633). The proposed “end-state” of the buildings will be either grass and/or gravel pads. Through the NHPA Section 106 consultation process, measures to mitigate the adverse impacts of demolition were determined and agreed to through a Memorandum of Agreement (MOA) between DOE-ID, SHPO, and ACHP. The measures include the development and installation of interpretive signs to be placed at a publicly accessible location, retention of original components of CF-633, and completion of this HALS standard format report. Buildings, infrastructure, and features that are not scheduled for removal are documented here as well as properties that are scheduled for removal and the overall Arco NPG landscape. The Arco NPG, located in the remote high-desert of eastern Idaho aided in the defense and eventual ally victory in the Pacific Theater of World War II, in addition to revising national standards for the safe storage and transport of conventional ordnance.

  20. A hierarchical approach to ecological assessment of contaminated soils at Aberdeen Proving Ground, USA

    Energy Technology Data Exchange (ETDEWEB)

    Kuperman, R.G.

    1995-12-31

    Despite the expansion of environmental toxicology studies over the past decade, soil ecosystems have largely been ignored in ecotoxicological studies in the United States. The objective of this project was to develop and test the efficacy of a comprehensive methodology for assessing ecological impacts of soil contamination. A hierarchical approach that integrates biotic parameters and ecosystem processes was used to give insight into the mechanisms that lead to alterations in the structure and function of soil ecosystems in contaminated areas. This approach involved (1) a thorough survey of the soil biota to determine community structure, (2) laboratory and field tests on critical ecosystem processes, (3) toxicity trials, and (4) the use of spatial analyses to provide input to the decision-making, process. This methodology appears to, offer an efficient and potentially cost-saving tool for remedial investigations of contaminated sites.

  1. Assessment of Aberdeen Proving Ground - Army Contracting Command, Contract Management Processes

    Science.gov (United States)

    2015-04-11

    transparency within public administration (Schapper et al., 2006). “ Value for money is the core principle governing public procurement and is supported...2008, p.782). In turn, public entities should strive to achieve the “ value for money ” for the public through use of elements to include customer...achieving value for money and providing the highest quality services and products to the customer (Cavanagh et al., 1999). Weele (2010) conducted a

  2. ESTCP Munitions Response Live Site Demonstrations, Former Southwestern Proving Ground, Arkansas Demonstration Report

    Science.gov (United States)

    2015-07-01

    three transmitters and 21 receiver loops. The collected data were inverted and analyzed using the UX-Analyze Advanced module in Geosoft Oasis montaj ...on 2,116 targets. The static cued data were processed using Geosoft Oasis montaj software, Advanced UX-Analyze module to extract the three principal...converted to ASCII *.CSV files using Geometrics EM3D data conversion software. Converted data were then imported into Geosoft Oasis montaj for processing

  3. Conference on Receptor-Based Biosensors (3rd) Held in Aberdeen Proving Ground, Maryland, September 1987

    Science.gov (United States)

    1988-07-01

    residue, or a serine, threonine , %r cystidine. We looked at ATP hydrolysis with this and we didn’t gai any advantage. When we restricted it by...chosen, azobenzene is found in literature going back to about the early 1940’s. Azohenzene 92 is essentially nonpolar with no dipole moment in its normal...compatibility, and an azobenzene derived hydroxyMthylaorylamide monomer to give us this photo conformational property. A small amount of monomer with a reactive

  4. Jefferson Proving Ground, South of the Firing Line Health and Safety Plan, Volume 4

    National Research Council Canada - National Science Library

    1992-01-01

    .... The purpose of this Site Health and Safety Plan (SHSP) is to assign SECD personnel health and safety responsibilities, to prescribe mandatory operating procedures, and to establish personal-protective-equipment (PPE...

  5. Personnel and Vehicle Data Collection at Aberdeen Proving Ground (APG) and its Distribution for Research

    Science.gov (United States)

    2015-10-01

    walker’s zig zag pattern...............................................................6 Fig. 7 Day 3 walker’s line horizontal pattern...m apart. Fig. 4 Day 3 walker’s heavy right wedge pattern 6 Fig. 5 Day 3 walker’s diamond pattern Fig. 6 Day 3 walker’s zig zag pattern

  6. Operation JANGLE. Nevada Proving Grounds, October-November 1951. Tests of Service Equipment and Operation

    Science.gov (United States)

    1952-07-01

    ricrocurie of ejvln Sr 9 0 3--e retained in the body). a- PRO=EC 6.3-2 I T-. ii -T -O R I 05 a. 10-6 ISO are reandi tebd) I ii 26 I’~~lawI~ JioJE-T 6.3-2 was...Contaminated Water: Suspended Turbidity 1.7 4 x 10-2 38500 Disuolved 0.85 x 10-2 18820 Total 2.59 x 10-2 57320 After Slurrying with Pow- 0.86 x 10-2 19100... 38500 (suspended turbidity from laboratory f il- tration) 30.75 " " 32870 45.20 M 27036 69.75 " 19630 6.62 Contaminated water 18820 (filtrate from

  7. Design of a Control Moment Gyroscope Attitude Actuation System for the Attitude Control Subsystem Proving Ground

    Science.gov (United States)

    2013-03-01

    control using a CMG array is prone to geometric singularities. Singularities are commonly avoided by limiting a vehicle’s performance via limitation of the...ball bearings, tolerancing and fitting, materials, or balancing. For help in these areas, where I had only general knowledge, we looked to experts

  8. Dugway Proving Ground: Closure Plan Module 2, for SWMUs 20, 164, 166 and 170

    Science.gov (United States)

    1997-07-01

    PAGE wApme Pubiner soll Moo"" NtIso doem~ me soW N mq Va S amoay uaggm 8=0 "porn soV b~ Someo a a" motra~ioofso -.,,d I, bi~mn bainowi amemminea fr...cross the placenta and accumulate in the amniotic fluid (Danielsson and others, 1986). Associated developmental effects of high doses of chloroform in...inhalation exposure to chromium (VI) compounds. Other effects observed following chromium (VI) exposure include effects on the immune system, nervous

  9. 76 FR 2607 - Airworthiness Directives; MD Helicopters, Inc. (MDHI) Model MD900 Helicopters

    Science.gov (United States)

    2011-01-14

    ... MDHI Model MD900 helicopters. That AD currently requires turning on both Vertical Stabilizer Control... Stability Augmentation System (YSAS) for the Model 500N and 600N helicopters and to the VSCS for the Model... also requires turning ON both VSCS switches to reduce pilot workload and to help control the helicopter...

  10. Combining Rosetta with molecular dynamics (MD): A benchmark of the MD-based ensemble protein design.

    Science.gov (United States)

    Ludwiczak, Jan; Jarmula, Adam; Dunin-Horkawicz, Stanislaw

    2018-02-14

    Computational protein design is a set of procedures for computing amino acid sequences that will fold into a specified structure. Rosetta Design, a commonly used software for protein design, allows for the effective identification of sequences compatible with a given backbone structure, while molecular dynamics (MD) simulations can thoroughly sample near-native conformations. We benchmarked a procedure in which Rosetta design is started on MD-derived structural ensembles and showed that such a combined approach generates 20-30% more diverse sequences than currently available methods with only a slight increase in computation time. Importantly, the increase in diversity is achieved without a loss in the quality of the designed sequences assessed by their resemblance to natural sequences. We demonstrate that the MD-based procedure is also applicable to de novo design tasks started from backbone structures without any sequence information. In addition, we implemented a protocol that can be used to assess the stability of designed models and to select the best candidates for experimental validation. In sum our results demonstrate that the MD ensemble-based flexible backbone design can be a viable method for protein design, especially for tasks that require a large pool of diverse sequences. Copyright © 2018 Elsevier Inc. All rights reserved.

  11. 25 CFR 11.702 - Proving and admitting will.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Proving and admitting will. 11.702 Section 11.702 Indians... ORDER CODE Probate Proceedings § 11.702 Proving and admitting will. (a) Upon initiating the probate of an estate, the will of the decedent shall be filed with the court. Such will may be proven and...

  12. Reasoning and Proving Opportunities in Textbooks: A Comparative Analysis

    Science.gov (United States)

    Hong, Dae S.; Choi, Kyong Mi

    2018-01-01

    In this study, we analyzed and compared reasoning and proving opportunities in geometry lessons from American standard-based textbooks and Korean textbooks to understand how these textbooks provide student opportunities to engage in reasoning and proving activities. Overall, around 40% of exercise problems in Core Plus Mathematics Project (CPMP)…

  13. The Earth is Flat, and I Can Prove It!

    Science.gov (United States)

    Klinger, Art

    1998-01-01

    Describes an educational program that asks students to attempt to prove that the earth is spherical and that it rotates. Presents tips to pique student interest and charts related to sensing the spin, nonrotation notions, flat earth fallacies, evidence that the earth is spherical and rotates, and the role of watersheds in proving that the earth…

  14. 20 CFR 219.23 - Evidence to prove death.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Evidence to prove death. 219.23 Section 219... EVIDENCE REQUIRED FOR PAYMENT Evidence of Age and Death § 219.23 Evidence to prove death. (a) Preferred evidence of death. The best evidence of a person's death is— (1) A certified copy of or extract from the...

  15. Medical paternalism in House M.D.

    Science.gov (United States)

    Wicclair, M R

    2008-12-01

    The popular television series House M.D. is drawn upon to provide a critical examination of medical paternalism and how it is presented in the show. Dr Gregory House, the character named in the title of the series, is a paradigm of a paternalistic physician. He believes that he knows what is best for his patients, and he repeatedly disregards their wishes in order to diagnose and treat their illnesses. This paper examines several examples of medical paternalism and the means used to portray it favourably in the series. It is argued that the positive depiction of medical paternalism in the fictional world of the series does not apply in the real world. The paper also considers why a show that features a paternalistic physician who so blatantly flouts mainstream medical ethics might appeal to health professionals and members of the general public.

  16. Beam-Based Collimator Alignment MD

    CERN Document Server

    Assmann, R; Muller, GJ; Redaelli, S; Salvachua, B; Valentino, G

    2012-01-01

    The MD was performed on 21st April 2012, and was split into two parts. First, the alignment of a horizontal IR3 collimator was performed at different Dp/p cuts of the IR3 TCP to observe any improvements in the BLM spike quality. Secondly, new additions to the beam-based collimator alignment software aimed at speeding up the alignment were tested. The new features include coarse alignment of the collimator jaws around the BPM-interpolated orbit and new sequences in the parallel alignment algorithm to ensure that both jaws touch the beam before fine sequential alignment can proceed. The new software allowed 27 collimators to be aligned in 1 hour 45 minutes, which translates to a total of 5.5 hours for all collimators, an improvement of 2 hours over the previous best time achieved in the March 2012 setups.

  17. MD1228: Validation of Single Bunch Stability Threshold & MD1751: Instability Studies with a Single Beam

    CERN Document Server

    Carver, Lee Robert; Biancacci, Nicolo; Buffat, Xavier; Iadarola, Giovanni; Lasocha, Kacper; Li, Kevin Shing Bruce; Levens, Tom; Metral, Elias; Salvant, Benoit; Tambasco, Claudia; CERN. Geneva. ATS Department

    2017-01-01

    Instabilities were being routinely observed in B1V during ADJUST. The timing of the instabilities has been localised to shortly after the TOTEM bump has been implemented. The result is emittance blowup which can negatively effect the luminosity output of the fill. This MD aimed to rule out possible sources of the instability (i.e. beam-beam effects or electron cloud) by only taking one single beam to 6.5TeV and going through the full machine cycle. After the implementation of the TOTEM bump, a reduction of the octupole current was performed in order to determine if there was a discrepancy in the threshold between simulations and measurement. As a precursor, the results of the End of Fill MD: Validation of Single Bunch Stability Threshold will also be described.

  18. Orbit Feedback Operation with RCBX (MD 1209)

    CERN Document Server

    Wenninger, Jorg; Nisbet, David; Ponce, Laurette; Louro Alves, Diogo Miguel; CERN. Geneva. ATS Department

    2017-01-01

    The LHC Orbit Feedback (OFB) is able to drive any orbit corrector circuit (COD) to steer the LHC orbit. But during the first feedback tests in 2010, all attempts to use the common triplet orbit correctors (MCBX) failed because the QPS system installed to protect those magnets triggered power aborts as soon as the OFB steered the beam with those CODs. The reason was most likely the violation of the RCBX circuit acceleration limits. For this reason the MCBX orbit correctors were never driven by the OFB in regular operation. Although the performance of the OFB is generally excellent, the quality of the beam steering around IRs could be improved if the OFB could correct the orbit with the MCBX to counteract locally triplet quadrupole movements. The aim of this MD was to make a new attempt to use the MCBX in the OFB. The test was successful at injection (no circuit trip) and failed during the ramp (QPS power abort). The PC voltages and QPS Ures signals revealed the presence of voltage spikes with a period of 10~s...

  19. Waiting time distribution in M/D/1 queueing systems

    DEFF Research Database (Denmark)

    Iversen, Villy Bæk; Staalhagen, Lars

    1999-01-01

    The well-known formula for the waiting time distribution of M/D/1 queueing systems is numerically unsuitable when the load is close to 1.0 and/or the results for a large waiting time are required. An algorithm for any load and waiting time is presented, based on the state probabilities of M/D/1...

  20. MD290: Q4 IP6 Quench Level

    CERN Document Server

    Bednarek, Mateusz Jakub; Lechner, Anton; CERN. Geneva. ATS Department

    2016-01-01

    The detailed program proposed for the LHC Machine Development concerning a quench induced by fast losses on the MQY.4L6 quadrupole is presented. The merit of the MD, the necessary modifications of the machine protection systems are presented together with a preliminary analysis of the MD results.

  1. Chosen-Prefix Collisions for MD5 and Applications

    NARCIS (Netherlands)

    M.M.J. Stevens (Marc); A.K. Lenstra (Arjen); B. de Weger (Benne)

    2012-01-01

    textabstractWe present a novel, automated way to find differential paths for MD5. Its main application is in the construction of \\emph{chosen-prefix collisions}. We have shown how, at an approximate expected cost of $2^{39}$ calls to the MD5 compression function, for any two chosen

  2. PROVE Surface albedo of Jornada Experimental Range, New Mexico, 1997

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of this study was to determine the spatial variations in field measurements of broadband albedo as related to the ground cover and under a range of...

  3. PROVE Surface albedo of Jornada Experimental Range, New Mexico, 1997

    Data.gov (United States)

    National Aeronautics and Space Administration — ABSTRACT: The objective of this study was to determine the spatial variations in field measurements of broadband albedo as related to the ground cover and under a...

  4. Lodox Statscan proves to be invaluable in forensic medicine ...

    African Journals Online (AJOL)

    Lodox Statscan proves to be invaluable in forensic medicine: forensic files. GJ Knobel, G Flash, GF Bowie. Abstract. No Abstract. South African Medical Journal Vol. 96(7) 2006: 593-594. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · AJOL African Journals ...

  5. Conditional and preferential logics proof methods and theorem proving

    CERN Document Server

    Pozzato, GL

    2010-01-01

    Contains a version of the author's PhD dissertation and focuses on proof methods and theorem proving for conditional and preferential logics. This book introduces proof methods (sequent and tableau calculi) for conditional and preferential logics, as well as theorem provers obtained by implementing the proposed calculi.

  6. Proving the correctness of client/server software

    Indian Academy of Sciences (India)

    , formal specification and verification of RPC mechanisms is a prerequisite for the verification of any such software. In this paper, we present a mathematical specification of an RPC mechanism and we outline how to prove the correctness of an ...

  7. Overcoming the Obstacle of Poor Knowledge in Proving Geometry Tasks

    Directory of Open Access Journals (Sweden)

    Zlatan Magajna

    2013-12-01

    Full Text Available Proving in school geometry is not just about validating the truth of a claim. In the school setting, the main function of the proof is to convince someone that a claim is true by providing an explanation. Students consider proving to be difficult; in fact, they find the very concept of proof demanding. Proving a claim in planar geometry involves several processes, the most salient being visual observation and deductive argumentation. These two processes are interwoven, but often poor observation hinders deductive argumentation. In the present article, we consider the possibility of overcoming the obstacle of a student’s poor observation by making use of computer-aided observation with appropriate software. We present the results of two small-scale research projects, both of which indicate that students are able to work out considerably more deductions if computer-aided observation is used. Not all students use computer-aided observation effectively in proving tasks: some find an exhaustive computer-provided list of properties confusing and are not able to choose the properties that are relevant to the task.

  8. Engaging Students in Proving: A Double Bind on the Teacher.

    Science.gov (United States)

    Herbst, Patricio G.

    2002-01-01

    Explores what is involved in the teacher's work of engaging students in producing a proof. Analyzes what teachers do to create a task in which students can produce a proof and what teachers do to get students to prove a proposition. Indicates that traditional, formal, two-column proofs place contradictory demands on teachers regarding how ideas…

  9. Proof phenomenon as a function of the phenomenology of proving.

    Science.gov (United States)

    Hipólito, Inês

    2015-12-01

    Kurt Gödel wrote (1964, p. 272), after he had read Husserl, that the notion of objectivity raises a question: "the question of the objective existence of the objects of mathematical intuition (which, incidentally, is an exact replica of the question of the objective existence of the outer world)". This "exact replica" brings to mind the close analogy Husserl saw between our intuition of essences in Wesensschau and of physical objects in perception. What is it like to experience a mathematical proving process? What is the ontological status of a mathematical proof? Can computer assisted provers output a proof? Taking a naturalized world account, I will assess the relationship between mathematics, the physical world and consciousness by introducing a significant conceptual distinction between proving and proof. I will propose that proving is a phenomenological conscious experience. This experience involves a combination of what Kurt Gödel called intuition, and what Husserl called intentionality. In contrast, proof is a function of that process - the mathematical phenomenon - that objectively self-presents a property in the world, and that results from a spatiotemporal unity being subject to the exact laws of nature. In this essay, I apply phenomenology to mathematical proving as a performance of consciousness, that is, a lived experience expressed and formalized in language, in which there is the possibility of formulating intersubjectively shareable meanings. Copyright © 2015. Published by Elsevier Ltd.

  10. Feedback theory extended for proving generation of contraction semigroups

    NARCIS (Netherlands)

    Kurula, Mikael; Zwart, Hans

    2016-01-01

    Recently, the following novel method for proving the existence of solutions for certain linear time-invariant PDEs was introduced: The operator associated with a given PDE is represented by a (larger) operator with an internal loop. If the larger operator (without the internal loop) generates a

  11. Prove It! Putting Together the Evidence-Based Practice Puzzle

    Science.gov (United States)

    Little, Hannah Byrd

    2015-01-01

    Why is it important to prove that school libraries add value to the school program? The National Center for Education Statistics reports that 20 percent of U.S. public schools lack a full or part-time certified librarian (NCES 2013). In California the ratio of certified school librarians to students is 1:7,374 (California Department of Education…

  12. Pengembangan Perangkat Pembelajaran Geometri Ruang dengan Model Proving Theorem

    Directory of Open Access Journals (Sweden)

    Bambang Eko Susilo

    2016-03-01

    Full Text Available Kemampuan berpikir kritis dan kreatif mahasiswa masih lemah. Hal ini ditemukan pada mahasiswa yang mengambil mata kuliah Geometri Ruang yaitu dalam membuktikan soal-soal pembuktian (problem to proof. Mahasiswa masih menyelesaikan secara algoritmik atau prosedural sehingga diperlukan pengembangan perangkat pembelajaran Geometri Ruang berbasis kompetensi dan konservasi dengan model Proving Theorem. Dalam penelitian ini perangkat perkuliahan yang dikembangkan yaitu Silabus, Satuan Acara Perkuliahan (SAP, Kontrak Perkuliahan, Media Pembelajaran, Bahan Ajar, Tes UTS dan UAS serta Angket Karakter Konservasi telah dilaksanakan dengan baik dengan kriteria (1 validasi perangkat pembelajaran mata kuliah Geometri ruang berbasis kompetensi dan konservasi dengan model proving theorem berkategori baik dan layak digunakan dan (2 keterlaksanaan RPP pada pembelajaran yang dikembangkan secara keseluruhan berkategori baik.Critical and creative thinking abilities of students still weak. It is found in students who take Space Geometry subjects that is in solving problems to to prove. Students still finish in algorithmic or procedural so that the required the development of Space Geometry learning tools based on competency and conservation with Proving Theorem models. This is a research development which refers to the 4-D models that have been modified for the Space Geometry learning tools, second semester academic year 2014/2015. Instruments used include validation sheet, learning tools and character assessment questionnaire. In this research, the learning tools are developed, namely Syllabus, Lesson Plan, Lecture Contract, Learning Media, Teaching Material, Tests, and Character Conservation Questionnaire had been properly implemented with the criteria (1 validation of Space Geometry learning tools based on competency and conservation with Proving Theorem models categorized good and feasible to use, and (2 the implementation of Lesson Plan on learning categorized

  13. MD 239 on Collide and Squeeze (part 2)

    CERN Document Server

    Gorzawski, Arkadiusz; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; CERN. Geneva. ATS Department

    2016-01-01

    Colliding the beams during the squeeze to profit from Landau damping due to head--on beam-beam and beta--star leveling are two operational modes that may have to be used in a not so distant future at the LHC. This MD aimed at improving the orbit control during the squeeze with much improved handling of orbit feedback references and at evaluating instruments and techniques to maintain the beam in collisions with active feedback on luminosity or beam position. This MD also integrated for the first time synchronized collimator measurements. Comparison of the settings with the previous MD allowed a validation of the long term stability of collide and squeeze.

  14. Preparing MD-PhD students for clinical rotations: navigating the interface between PhD and MD training.

    Science.gov (United States)

    Goldberg, Charles; Insel, Paul A

    2013-06-01

    Many aspects of MD-PhD training are not optimally designed to prepare students for their future roles as translational clinician-scientists. The transition between PhD research efforts and clinical rotations is one hurdle that must be overcome. MD-PhD students have deficits in clinical skills compared with those of their MD-only colleagues at the time of this transition. Reimmersion programs (RPs) targeted to MD-PhD students have the potential to help them navigate this transition.The authors draw on their experience creating and implementing an RP that incorporates multiple types of activities (clinical exam review, objective structured clinical examination, and supervised practice in patient care settings) designed to enhance the participants' skills and readiness for clinical efforts. On the basis of this experience, they note that MD-PhD students' time away from the clinical environment negatively affects their clinical skills, causing them to feel underprepared for clinical rotations. The authors argue that participation in an RP can help students feel more comfortable speaking with and examining patients and decrease their anxiety regarding clinical encounters. The authors propose that RPs can have positive outcomes for improving the transition from PhD to clinical MD training in dual-degree programs. Identifying and addressing this and other transitions need to be considered to improve the educational experience of MD-PhD students.

  15. Unicorns do exist: a tutorial on "proving" the null hypothesis.

    Science.gov (United States)

    Streiner, David L

    2003-12-01

    Introductory statistics classes teach us that we can never prove the null hypothesis; all we can do is reject or fail to reject it. However, there are times when it is necessary to try to prove the nonexistence of a difference between groups. This most often happens within the context of comparing a new treatment against an established one and showing that the new intervention is not inferior to the standard. This article first outlines the logic of "noninferiority" testing by differentiating between the null hypothesis (that which we are trying to nullify) and the "nill" hypothesis (there is no difference), reversing the role of the null and alternate hypotheses, and defining an interval within which groups are said to be equivalent. We then work through an example and show how to calculate sample sizes for noninferiority studies.

  16. Programming and Proving Correctness of the Scanning Algorithm with Backtrack,

    Science.gov (United States)

    1980-09-19

    components A, . A2,...An of the Cartesian product and that all eie- ments of the set A are generated sequentially from them. It is simplest to program how n...the gradual refine- ment of the program and proving its correctness and we do not work towards a meaningful program which will solve a given problem and...Privara, I..- " Teoria a aplikacia formalnej semantiky programovacich jazykov" LThe Theory and Application of ?ormal Semantics in Program- .m~ng

  17. Logic for computer science foundations of automatic theorem proving

    CERN Document Server

    Gallier, Jean H

    2015-01-01

    This advanced text for undergraduate and graduate students introduces mathematical logic with an emphasis on proof theory and procedures for algorithmic construction of formal proofs. The self-contained treatment is also useful for computer scientists and mathematically inclined readers interested in the formalization of proofs and basics of automatic theorem proving. Topics include propositional logic and its resolution, first-order logic, Gentzen's cut elimination theorem and applications, and Gentzen's sharpened Hauptsatz and Herbrand's theorem. Additional subjects include resolution in fir

  18. beta* leveling with telescopic ATS squeeze (MD 2410)

    CERN Document Server

    Wenninger, Jorg; Hostettler, Michi; Pojer, Mirko; Ponce, Laurette; Tydecks, Tobias; CERN. Geneva. ATS Department

    2017-01-01

    Luminosity leveling by beta* is the baseline operational scenario of HL-LHC, and this leveling technique may be used in 2018 or during run~3 depending on the beam parameters and beta* range. During this MD beta*leveling was commissioned successfully for the first time with the telescopic squeeze over the beta* range of 40 cm to 30 cm. A novel beta* leveling controls technique based on a modification of the LSA trim was also tested during the MD.

  19. Md-miR156ab and Md-miR395 Target WRKY Transcription Factors to Influence Apple Resistance to Leaf Spot Disease.

    Science.gov (United States)

    Zhang, Qiulei; Li, Yang; Zhang, Yi; Wu, Chuanbao; Wang, Shengnan; Hao, Li; Wang, Shengyuan; Li, Tianzhong

    2017-01-01

    MicroRNAs (miRNAs) are key regulators of gene expression that post-transcriptionally regulate transcription factors involved in plant physiological activities. Little is known about the effects of miRNAs in disease resistance in apple (Malus×domestica). We globally profiled miRNAs in the apple cultivar Golden Delicious (GD) infected or not with the apple leaf spot fungus Alternaria alternaria f. sp. mali (ALT1), and identified 58 miRNAs that exhibited more than a 2-fold upregulation upon ALT1 infection. We identified a pair of miRNAs that target protein-coding genes involved in the defense response against fungal pathogens; Md-miR156ab targets a novel WRKY transcription factor, MdWRKYN1, which harbors a TIR and a WRKY domain. Md-miR395 targets another transcription factor, MdWRKY26, which contains two WRKY domains. Real-time PCR analysis showed that Md-miR156ab and Md-miR395 levels increased, while MdWRKYN1 and MdWRKY26 expression decreased in ALT1-inoculated GD leaves; furthermore, the overexpression of Md-miR156ab and Md-miR395 resulted in a significant reduction in MdWRKYN1 and MdWRKY26 expression. To investigate whether these miRNAs and their targets play a crucial role in plant defense, we overexpressed MdWRKYN1 or knocked down Md-miR156ab activity, which in both cases enhanced the disease resistance of the plants by upregulating the expression of the WRKY-regulated pathogenesis-related (PR) protein-encoding genes MdPR3-1, MdPR3-2, MdPR4, MdPR5, MdPR10-1, and MdPR10-2. In a similar analysis, we overexpressed MdWRKY26 or suppressed Md-miR395 activity, and found that many PR protein-encoding genes were also regulated by MdWRKY26. In GD, ALT-induced Md-miR156ab and Md-miR395 suppress MdWRKYN1 and MdWRKY26 expression, thereby decreasing the expression of some PR genes, and resulting in susceptibility to ALT1.

  20. Grounded theory

    OpenAIRE

    Harris, Tina

    2014-01-01

    Grounded theory is a popular research approach in health care and the social sciences. This article provides a description of grounded theory methodology and its key components, using examples from published studies to demonstrate practical application. It aims to demystify grounded theory for novice nurse researchers, by explaining what it is, when to use it, why they would want to use it and how to use it. It should enable nurse researchers to decide if grounded theory is an appropriate app...

  1. Proving Causation With Epidemiological Evidence in Tobacco Lawsuits

    Directory of Open Access Journals (Sweden)

    Sun Goo Lee

    2016-03-01

    Full Text Available Recently, a series of lawsuits were filed in Korea claiming tort liability against tobacco companies. The Supreme Court has already issued decisions in some cases, while others are still pending. The primary issue in these cases is whether the epidemiological evidence submitted by the plaintiffs clearly proves the causal relationship between smoking and disease as required by civil law. Proving causation is difficult in tobacco lawsuits because factors other than smoking are involved in the development of a disease, and also because of the lapse of time between smoking and the manifestation of the disease. The Supreme Court (Supreme Court Decision, 2011Da22092, April 10, 2014 has imposed some limitations on using epidemiological evidence to prove causation in tobacco lawsuits filed by smokers and their family members, but these limitations should be reconsidered. First, the Court stated that a disease can be categorized as specific or non-specific, and for each disease type, causation can be proven by different types of evidence. However, the concept of specific diseases is not compatible with multifactor theory, which is generally accepted in the field of public health. Second, when the epidemiological association between the disease and the risk factor is proven to be significant, imposing additional burdens of proof on the plaintiff may considerably limit the plaintiff’s right to recovery, but the Court required the plaintiffs to provide additional information such as health condition and lifestyle. Third, the Supreme Court is not giving greater weight to the evidential value of epidemiological study results because the Court focuses on the fact that these studies were group-level, not individual-level. However, group-level studies could still offer valuable information about individual members of the group, e.g., probability of causation.

  2. On proving confluence modulo equivalence for Constraint Handling Rules

    DEFF Research Database (Denmark)

    Christiansen, Henning; Kirkeby, Maja Hanne

    2017-01-01

    Previous results on proving confluence for Constraint Handling Rules are extended in two ways in order to allow a larger and more realistic class of CHR programs to be considered confluent. Firstly, we introduce the relaxed notion of confluence modulo equivalence into the context of CHR: while...... with meta-level restrictions that reflect the non-logical and incomplete predicates. This language represents subproofs as diagrams, which facilitates a systematic enumeration of proof cases, pointing forward to a mechanical support for such proofs. The Project is supported by The Danish...

  3. Grounded theory.

    Science.gov (United States)

    Harris, Tina

    2015-04-29

    Grounded theory is a popular research approach in health care and the social sciences. This article provides a description of grounded theory methodology and its key components, using examples from published studies to demonstrate practical application. It aims to demystify grounded theory for novice nurse researchers, by explaining what it is, when to use it, why they would want to use it and how to use it. It should enable nurse researchers to decide if grounded theory is an appropriate approach for their research, and to determine the quality of any grounded theory research they read.

  4. MD Family Medicine - Calicut experience: History is made here

    Directory of Open Access Journals (Sweden)

    M Roshni

    2016-01-01

    Full Text Available Government Medical College, Calicut, Kerala - the first medical college in India to start Doctor of Medicine (MD in family medicine as a postgraduate course. This was in the year 2012. Till date, this is the only medical college to have MD Family Medicine program in India. The college was allowed two MD Family Medicine seats per year by the Medical Council of India, and this is a 3 year course. The first batch of MD Family Medicine students has passed out from the Government Medical College, Calicut in July 2015. In this article, the author, who has been working as an assistant professor in the Department of Family Medicine, ever since the department started in the year 2012, shares her experiences in setting up the department, its functioning and the achievement of bringing out the first batch of successful MD Family Medicine specialists. Another laurel, of which the institution is proud of, is that they were able to incorporate family medicine teaching program in the MBBS curriculum. A brief introduction about Government Medical College, Calicut, is also given.

  5. Cummins MD & HD Accessory Hybridization CRADA -Annual Report FY15

    Energy Technology Data Exchange (ETDEWEB)

    Deter, Dean D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-10-01

    There are many areas of MD and HD vehicles that can be improved by new technologies and optimized control strategies. Component optimization and idle reduction need to be addressed, this is best done by a two part approach that includes selecting the best component technology, and/or architecture, and optimized controls that are vehicle focused. While this is a common focus in the light duty industry it has been gaining momentum in the MD and HD market as the market gets more competitive and the regulations become more stringent. When looking into systems optimization and idle reduction technologies, affected vehicle systems must first be considered, and if possible included in the new architecture to get the most benefit out of these new capabilities. Typically, when looking into idle reduction or component optimization for MD/HD, the vehicle s accessories become a prime candidate for electrification or hybridization. While this has already been studied on light duty vehicles (especially on hybrids and electric vehicles) it has not made any head way or market penetration in most MD and HD applications. If hybrids and electric MD and HD vehicles begin to break into the market this would be a necessary step into the ability to make those vehicles successful by allowing for independent, optimized operation separate from the engine.

  6. Model Checking Failed Conjectures in Theorem Proving: A Case Study

    Science.gov (United States)

    Pike, Lee; Miner, Paul; Torres-Pomales, Wilfredo

    2004-01-01

    Interactive mechanical theorem proving can provide high assurance of correct design, but it can also be a slow iterative process. Much time is spent determining why a proof of a conjecture is not forthcoming. In some cases, the conjecture is false and in others, the attempted proof is insufficient. In this case study, we use the SAL family of model checkers to generate a concrete counterexample to an unproven conjecture specified in the mechanical theorem prover, PVS. The focus of our case study is the ROBUS Interactive Consistency Protocol. We combine the use of a mechanical theorem prover and a model checker to expose a subtle flaw in the protocol that occurs under a particular scenario of faults and processor states. Uncovering the flaw allows us to mend the protocol and complete its general verification in PVS.

  7. Formal Analysis of Soft Errors using Theorem Proving

    Directory of Open Access Journals (Sweden)

    Sofiène Tahar

    2013-07-01

    Full Text Available Modeling and analysis of soft errors in electronic circuits has traditionally been done using computer simulations. Computer simulations cannot guarantee correctness of analysis because they utilize approximate real number representations and pseudo random numbers in the analysis and thus are not well suited for analyzing safety-critical applications. In this paper, we present a higher-order logic theorem proving based method for modeling and analysis of soft errors in electronic circuits. Our developed infrastructure includes formalized continuous random variable pairs, their Cumulative Distribution Function (CDF properties and independent standard uniform and Gaussian random variables. We illustrate the usefulness of our approach by modeling and analyzing soft errors in commonly used dynamic random access memory sense amplifier circuits.

  8. A Hybrid Approach to Proving Memory Reference Monotonicity

    KAUST Repository

    Oancea, Cosmin E.

    2013-01-01

    Array references indexed by non-linear expressions or subscript arrays represent a major obstacle to compiler analysis and to automatic parallelization. Most previous proposed solutions either enhance the static analysis repertoire to recognize more patterns, to infer array-value properties, and to refine the mathematical support, or apply expensive run time analysis of memory reference traces to disambiguate these accesses. This paper presents an automated solution based on static construction of access summaries, in which the reference non-linearity problem can be solved for a large number of reference patterns by extracting arbitrarily-shaped predicates that can (in)validate the reference monotonicity property and thus (dis)prove loop independence. Experiments on six benchmarks show that our general technique for dynamic validation of the monotonicity property can cover a large class of codes, incurs minimal run-time overhead and obtains good speedups. © 2013 Springer-Verlag.

  9. Ground Wars

    DEFF Research Database (Denmark)

    Nielsen, Rasmus Kleis

    Political campaigns today are won or lost in the so-called ground war--the strategic deployment of teams of staffers, volunteers, and paid part-timers who work the phones and canvass block by block, house by house, voter by voter. Ground Wars provides an in-depth ethnographic portrait of two...... of ground war tactics for how we understand political campaigns and what it means to participate in them. He shows how ground wars are waged using resources well beyond those of a given candidate and their staff. These include allied interest groups and civic associations, party-provided technical...... of professionals. Yet he also quashes the romantic idea that canvassing is a purer form of grassroots politics. In today's political ground wars, Nielsen demonstrates, even the most ordinary-seeming volunteer knocking at your door is backed up by high-tech targeting technologies and party expertise. Ground Wars...

  10. 3MdB: the Mexican Million Models database

    Science.gov (United States)

    Morisset, C.; Delgado-Inglada, G.

    2014-10-01

    The 3MdB is an original effort to construct a large multipurpose database of photoionization models. This is a more modern version of a previous attempt based on Cloudy3D and IDL tools. It is accessed by MySQL requests. The models are obtained using the well known and widely used Cloudy photoionization code (Ferland et al, 2013). The database is aimed to host grids of models with different references to identify each project and to facilitate the extraction of the desired data. We present here a description of the way the database is managed and some of the projects that use 3MdB. Anybody can ask for a grid to be run and stored in 3MdB, to increase the visibility of the grid and the potential side applications of it.

  11. BI MD Studies on June 29th 2011

    CERN Document Server

    Belohrad, D; Bravin, E; Calvo, E; Dehning, B; Emery, J; Favier, M; Gras, JJ; Guerrero, A; Jeff, A; Lefevre, T; Rabiller, A; Roncarolo, F; Sapinski, M; Soby, L; Steinhagen, R

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 29-June-2011 (from 10 p.m. to 07 a.m.), dedicated to study Beam Current Monitors (BCT), Wire Scaners (WS), Synchrotron Radiation (BSRT), Beam Position (BPM), Wall Current (WCM) and Beam Gas Ionization (BGI) monitors. The MD aimed at performing different studies on the individual monitors. At the same time, it was possible to perform calibration studies with the Abort Gap (AGM) and Longitudinal Density (LDM) monitors that share the extracted light with the BSRT. Additionally some observations about the beam stability and emittance dependence on the chromaticity were performed.

  12. Restructuring the syllabus for MD Pharmacology: Retrospection of bioassay

    Directory of Open Access Journals (Sweden)

    Sarita Mulkalwar

    2014-01-01

    Full Text Available Introduction: Career prospects in Pharmacology are witnessing a sea change due to fast and unanticipated development in the field of clinical research. Numerous openings exist now in academia, pharmaceutical industry, Clinical Research Organizations (CRO or as regulatory consultants, experimental pharmacologists, etc. In short, there are various options to choose from, depending on one′s interest. It′s high time we ponder now over the training programme for post-graduate students in Pharmacology. It needs to be revised keeping in mind the job prospects & uniqueness of the MD Pharmacology degree. Aim: To take suggestions of experienced pharmacologists on the present syllabus for MD Pharmacology and their opinion on continuation of Bioassay experiment which is currently an important part of it . Materials and Methods: A structured questionnaire was given to 30 experienced pharmacologists to seek their opinion on MD Pharmacology syllabus & continuation of Bioassay as a part of MD practical. Results: Out of 30 participants, 29 (96.6% did not use their knowledge of Bioassay during their 10 years of post MD career, whether in pharmaceutical industry or in academics. Only 5 of them (16.6% feel that experiment on bioassay should be continued in the current state. 76.7% of them wish it to be modified to a Dose Response Curve ( DRC . 6.71% feel that it should be totally scrapped. All the participants feel the need of revising current MD Pharmacology syllabus. Current syllabus is inclined more towards preparing good academicians but it lacks the proper training for creating good clinical research professionals. Medical writing, writing necessary documents for clinical trials including regulatory documents, writing an article for medical journals, marketing communication, product monograph and patient information of a clinical trial could be incorporated. They should be aware of the regulatory requirements for conducting studies on investigational drugs

  13. MD 2179: Scraping of off-momentum halo after injection

    CERN Document Server

    Garcia Morales, Hector; Patecki, Marcin; Wretborn, Sven Joel; CERN. Geneva. ATS Department

    2018-01-01

    In this MD, a beam scraping was performed using the momentum primary collimator in IR3 where dispersion is high. A second scraping was performed using a TCSG in IR7 where dispersion is almost negligible. In such a way, we aim to disentangle the contribution of off-momentum particles to halo population. These scrapings will provide useful information to better understand the usual off-momentum losses we see at the start of the ramp. The MD results would also be used to benchmark simulations of off-momentum beam losses in order to gain confidence in simulation models.

  14. Apple MdACS6 Regulates Ethylene Biosynthesis During Fruit Development Involving Ethylene-Responsive Factor.

    Science.gov (United States)

    Li, Tong; Tan, Dongmei; Liu, Zhi; Jiang, Zhongyu; Wei, Yun; Zhang, Lichao; Li, Xinyue; Yuan, Hui; Wang, Aide

    2015-10-01

    Ethylene biosynthesis in plants involves different 1-aminocyclopropane-1-carboxylic acid synthase (ACS) genes. The regulation of each ACS gene during fruit development is unclear. Here, we characterized another apple (Malus×domestica) ACS gene, MdACS6. The transcript of MdACS6 was observed not only in fruits but also in other tissues. During fruit development, MdACS6 was initiated at a much earlier stage, whereas MdACS3a and MdACS1 began to be expressed at 35 d before harvest and immediateley after harvest, respectively. Moreover, the enzyme activity of MdACS6 was significantly lower than that of MdACS3a and MdACS1, accounting for the low ethylene biosynthesis in young fruits. Overexpression of MdACS6 (MdACS6-OE) by transient assay in apple showed enhanced ethylene production, and MdACS3a was induced in MdACS6-OE fruits but not in control fruits. In MdACS6 apple fruits silenced by the virus-induced gene silencing (VIGS) system (MdACS6-AN), neither ethylene production nor MdACS3a transcript was detectable. In order to explore the mechanism through which MdACS3a was induced in MdACS6-OE fruits, we investigated the expression of apple ethylene-responsive factor (ERF) genes. The results showed that the expression of MdERF2 was induced in MdACS6-OE fruits and inhibited in MdACS6-AN fruits. Yeast one-hybrid assay showed that MdERF2 protein could bind to the promoter of MdACS3a. Moreover, down-regulation of MdERF2 in apple flesh callus led to a decrease of MdACS3a expression, demonstrating the regulation of MdERF2 on MdACS3a. The mechanism through which MdACS6 regulates the action of MdACS3a was discussed. © The Author 2015. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  15. Apple (Malus domestica) MdERF2 negatively affects ethylene biosynthesis during fruit ripening by suppressing MdACS1 transcription.

    Science.gov (United States)

    Li, Tong; Jiang, Zhongyu; Zhang, Lichao; Tan, Dongmei; Wei, Yun; Yuan, Hui; Li, Tianlai; Wang, Aide

    2016-12-01

    Ripening in climacteric fruit requires the gaseous phytohormone ethylene. Although ethylene signaling has been well studied, knowledge of the transcriptional regulation of ethylene biosynthesis is still limited. Here we show that an apple (Malus domestica) ethylene response factor, MdERF2, negatively affects ethylene biosynthesis and fruit ripening by suppressing the transcription of MdACS1, a gene that is critical for biosynthesis of ripening-related ethylene. Expression of MdERF2 was suppressed by ethylene during ripening of apple fruit, and we observed that MdERF2 bound to the promoter of MdACS1 and directly suppressed its transcription. Moreover, MdERF2 suppressed the activity of the promoter of MdERF3, a transcription factor that we found to bind to the MdACS1 promoter, thereby increasing MdACS1 transcription. We determined that the MdERF2 and MdERF3 proteins directly interact, and this interaction suppresses the binding of MdERF3 to the MdACS1 promoter. Moreover, apple fruit with transiently downregulated MdERF2 expression showed higher ethylene production and faster ripening. Our results indicate that MdERF2 negatively affects ethylene biosynthesis and fruit ripening in apple by suppressing the transcription of MdACS1 via multiple mechanisms, thereby acting as an antagonist of positive ripening regulators. Our findings offer a deep understanding of the transcriptional regulation of ethylene biosynthesis during climacteric fruit ripening. © 2016 The Authors The Plant Journal © 2016 John Wiley & Sons Ltd.

  16. Why prove it again? alternative proofs in mathematical practice

    CERN Document Server

    Dawson, Jr , John W

    2015-01-01

    This monograph considers several well-known mathematical theorems and asks the question, “Why prove it again?” while examining alternative proofs.   It  explores the different rationales mathematicians may have for pursuing and presenting new proofs of previously established results, as well as how they judge whether two proofs of a given result are different.  While a number of books have examined alternative proofs of individual theorems, this is the first that presents comparative case studies of other methods for a variety of different theorems. The author begins by laying out the criteria for distinguishing among proofs and enumerates reasons why new proofs have, for so long, played a prominent role in mathematical practice.  He then outlines various purposes that alternative proofs may serve.  Each chapter that follows provides a detailed case study of alternative proofs for particular theorems, including the Pythagorean Theorem, the Fundamental Theorem of Arithmetic, Desargues’ Theorem, the...

  17. Edward Jenner, MD, and the scourge that was.

    Science.gov (United States)

    White, P J; Shackelford, P G

    1983-09-01

    This article was inspired by the global eradication of smallpox in 1980. Rather than reiterate the recent history of this remarkable achievement, we have chosen to celebrate the event by reviewing the early history of smallpox immunization and the contribution of Edward Jenner, MD, to this endeavor. In addition, we present these historical events within the context of knowledge acquired by modern virologists.

  18. Physical Properties of Near-Earth Asteroid 2011 MD

    NARCIS (Netherlands)

    Mommert, M.; Farnocchia, D.; Hora, J. L.; Chesley, S. R.; Trilling, D. E.; Chodas, P. W.; Mueller, M.; Harris, A. W.; Smith, H. A.; Fazio, G. G.

    2014-01-01

    We report on observations of near-Earth asteroid 2011 MD with the Spitzer Space Telescope. We have spent 19.9 h of observing time with channel 2 (4.5 {\\mu}m) of the Infrared Array Camera and detected the target within the 2{\\sigma} positional uncertainty ellipse. Using an asteroid thermophysical

  19. BayesMD: flexible biological modeling for motif discovery

    DEFF Research Database (Denmark)

    Tang, Man-Hung Eric; Krogh, Anders; Winther, Ole

    2008-01-01

    We present BayesMD, a Bayesian Motif Discovery model with several new features. Three different types of biological a priori knowledge are built into the framework in a modular fashion. A mixture of Dirichlets is used as prior over nucleotide probabilities in binding sites. It is trained on trans...

  20. Thomas Secker M.D.: Archbishop and man-midwife.

    Science.gov (United States)

    Morgan-Guy, John

    2018-01-01

    This paper provides a biographical outline of the career of Thomas Secker, MD, who from 1758-68 was Archbishop of Canterbury. Although much has been written on Secker, this study seeks to highlight his training in medicine, which has been largely overlooked hitherto by historians.

  1. MD SIMULATION OF SUBTILISIN BPN' IN A CRYSTAL ENVIRONMENT

    NARCIS (Netherlands)

    HEINER, AP; BERENDSEN, HJC; VANGUNSTEREN, WF

    1992-01-01

    In this paper we present a molecular dynamics (MD) simulation of subtilisin BPN' in a crystalline environment containing four protein molecules and solvent. Conformational and dynamic properties of the molecules are compared with each other and with respect to the X-ray structure to test the

  2. Geotechnics - the key to ground water protection

    DEFF Research Database (Denmark)

    Baumann, Jens; Foged, Niels; Jørgensen, Peter

    2000-01-01

    During the past 5 to 10 years research into ground water protection has proved that fractures in clay till may increase the hydraulic conductivity and herby the vulnerability of the ground water considerably. However, research has not identified a non-expensive and efficient method to map...... the character of a certain type of clay till and hereby find the necessary tool in future geographical mapping of the vulnerability of the ground water resources....

  3. MdCOP1 ubiquitin E3 ligases interact with MdMYB1 to regulate light-induced anthocyanin biosynthesis and red fruit coloration in apple.

    Science.gov (United States)

    Li, Yuan-Yuan; Mao, Ke; Zhao, Cheng; Zhao, Xian-Yan; Zhang, Hua-Lei; Shu, Huai-Rui; Hao, Yu-Jin

    2012-10-01

    MdMYB1 is a crucial regulator of light-induced anthocyanin biosynthesis and fruit coloration in apple (Malus domestica). In this study, it was found that MdMYB1 protein accumulated in the light but degraded via a ubiquitin-dependent pathway in the dark. Subsequently, the MdCOP1-1 and MdCOP1-2 genes were isolated from apple fruit peel and were functionally characterized in the Arabidopsis (Arabidopsis thaliana) cop1-4 mutant. Yeast (Saccharomyces cerevisiae) two-hybrid, bimolecular fluorescence complementation, and coimmunoprecipitation assays showed that MdMYB1 interacts with the MdCOP1 proteins. Furthermore, in vitro and in vivo experiments indicated that MdCOP1s are necessary for the ubiquitination and degradation of MdMYB1 protein in the dark and are therefore involved in the light-controlled stability of the MdMYB1 protein. Finally, a viral vector-based transformation approach demonstrated that MdCOP1s negatively regulate the peel coloration of apple fruits by modulating the degradation of the MdMYB1 protein. Our findings provide new insight into the mechanism by which light controls anthocyanin accumulation and red fruit coloration in apple and even other plant species.

  4. MD 382: Beam Transfer Function and diffusion mechanisms

    CERN Document Server

    Tambasco, Claudia; Buffat, Xavier; Crouch, Matthew; Pieloni, Tatiana; Boccardi, Andrea; Fuchsberger, Kajetan; Gasior, Marek; Kotzian, Gerd; Lefevre, Thibaut; Pojer, Mirko; Salvachua Ferrando, Belen Maria; Solfaroli Camillocci, Matteo; Giachino, Rossano; CERN. Geneva. ATS Department

    2016-01-01

    The Beam Transfer Function (BTF) measurements have been previously tested in the LHC during MD block 1 and 2. Different machine configurations (i.e. energy, beam intensity, emittance etc...) have been tested to determine a safe set-up (excitation amplitude) of the system to be completely transparent to the beam (no emittance blow-up neither losses). The aim of this experiment in MD block 3 was to characterize the Stability Diagram (SD) in the presence of diffusion mechanisms induced by excited resonances due to beam-beam long range and Landau octupole interplay. During the experiment, BTF measurements have been acquired at flat top for different settings of Landau octupole current, different chromaticity values and transverse feedback gains. In this note the description of the experiment is presented together with some preliminary results.

  5. MD 1856 - Landau Damping: Beam Transfer Functions and diffusion mechanisms

    CERN Document Server

    Tambasco, Claudia; Boccardi, Andrea; Buffat, Xavier; Gasior, Marek; Lefevre, Thibaut; Levens, Tom; Pojer, Mirko; Salvachua Ferrando, Belen Maria; Solfaroli Camillocci, Matteo; Pieloni, Tatiana; Crouch, Matthew Paul; CERN. Geneva. ATS Department

    2017-01-01

    In the 2012, 2015 and 2016 several instabilities were developing during the betatron squeeze where beam-beam interactions become stronger modifying the tune spread provided by the octupoles magnets. Studies of the stability area computed by evaluating the dispersion integral for different tune spread couldn’t explain the 2012 observed instabilities during the squeeze. The size of the stability area given by the computed dispersion integral depends on the transverse tune spread but its shape is defined by the particle distribution in the beams. Therefore any change of the particle distribution due to for instance a diffusion from excited resonances can lead to a deterioration of the Landau stability area. The Beam Transfer Functions (BTF) measurements are direct measurement of the Stability Diagrams (SD). They are sensitive to the particle distribution and contain information about the transverse tune spread in the beams. In this MD we wanted to verify the findings of MD 1407 and try to explain observed inst...

  6. MD 1691: Active halo control using tune ripple at injection

    CERN Document Server

    Garcia Morales, Hector; Bruce, Roderik; Redaelli, Stefano; Fitterer, Miriam; Fiascaris, Maria; Nisbet, David; Thiesen, Hugues; Valentino, Gianluca; Xu, Chen; CERN. Geneva. ATS Department

    2017-01-01

    In this MD we performed halo excitation through tune ripple. This consists in an excitation that introduces new resonance sidebands around the existing resonance lines. In presence of sufficient detuning with amplitude, these sidebands can in principle affect only the dynamics of the halo particles at large amplitudes. Tune ripple was induced through a current modulation of the warm trim quadrupoles in IR7. This is the first time this method is experimentally tested at the LHC.

  7. Summary of LHC MD:377: Schottky pick-up

    CERN Document Server

    Betz, Michael; Lefevre, Thibaut; CERN. Geneva. ATS Department

    2015-01-01

    The main objective of this MD was to record Schottky spectra under well known machine conditions. In summary, 7 set-points for the chromaticity and 8 for the emittance have been established and Schottky spectra have been recorded for each setting. The data will be used to benchmark and develop different fitting algorithms. This note presents the initial attempt of curve-fitting and discusses its shortcomings.

  8. MD 349: Impedance Localization with AC-dipole

    CERN Document Server

    Biancacci, Nicolo; Metral, Elias; Salvant, Benoit; Papotti, Giulia; Persson, Tobias Hakan Bjorn; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the distribution of the transverse impedance of the LHC by observing the phase advance variation with intensity between the machine BPMs. Four injected bunches with different intensities are excited with an AC dipole and the turn by turn data is acquired from the BPM system. Through post-processing analysis the phase variation along the machine is depicted and, from this information, first conclusions of the impedance distribution can be drawn.

  9. Space charge studies in the PSB - MD report

    CERN Document Server

    Forte, V; Martini, M; Schmidt, F; Yu Molodozhentsev, A

    2014-01-01

    In the framework of the LHC Injectors Upgrade (LIU) project [1], this document summarizes the PSB Machine Development (MD) studies in 2012-2013, before the Long Shutdown 1 (LS1), focused on space charge eects analysis at the future 160 MeV injection energy from the Linac4. Different phenomena have been analysed to understand the behaviour of the machine and permit benchmarks with simulation codes.

  10. Anzibert A. Rugakingira, MD student, Tumaini University – KCM ...

    African Journals Online (AJOL)

    0655711075

    Anzibert A. Rugakingira, MD student, Tumaini University – KCM-. COLLEGE. DMSJ 2012; 19: 22-27 http://dx.doi.org/10.4314/dmsj.v19i1.5. 1.0 Abstract ..... den of disease, it spends less than 1% of the total global health expenditure. In this regard, innovative healthcare delivery and financing models will be needed to ensure ...

  11. Cross-scale MD simulations of dynamic strength of tantalum

    Science.gov (United States)

    Bulatov, Vasily

    2017-06-01

    Dislocations are ubiquitous in metals where their motion presents the dominant and often the only mode of plastic response to straining. Over the last 25 years computational prediction of plastic response in metals has relied on Discrete Dislocation Dynamics (DDD) as the most fundamental method to account for collective dynamics of moving dislocations. Here we present first direct atomistic MD simulations of dislocation-mediated plasticity that are sufficiently large and long to compute plasticity response of single crystal tantalum while tracing the underlying dynamics of dislocations in all atomistic details. Where feasible, direct MD simulations sidestep DDD altogether thus reducing uncertainties of strength predictions to those of the interatomic potential. In the specific context of shock-induced material dynamics, the same MD models predict when, under what conditions and how dislocations interact and compete with other fundamental mechanisms of dynamic response, e.g. twinning, phase-transformations, fracture. In collaboration with: Luis Zepeda-Ruiz, Lawrence Livermore National Laboratory; Alexander Stukowski, Technische Universitat Darmstadt; Tomas Oppelstrup, Lawrence Livermore National Laboratory. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  12. MD2036: UFO Dynamics Studies and UFO Fast Detection

    CERN Document Server

    Belanger, Philippe; Valette, Matthieu; Lindstrom, Bjorn Hans Filip; Grob, Laura Katharina; Schmidt, Rudiger; Wollmann, Daniel

    2017-01-01

    UFOs are one of the remaining unknown related to LHC operation. Therefore, improving the understanding of UFO dynamics and validating the developed models against direct beam measurements is of fundamental importance in view of LHC operation at 7 TeV and with HL-LHC beam intensities. If not understood, UFOs could also be a showstopper for future machines such as FCC. This MD demonstrates new methods to study the dynamic behaviour of a calibrated UFO, simulated by the interaction of wire scanners with the beam. The events created during the MD were monitored using diamond BLMs in IR7, providing bunch-by-bunch resolution measurements. The analysis presented herein shows that blown-up bunches can be used to identify the plane of movement of UFOs, that bunch profiles and bunch sizes can be measured with dBLMs with good precision, that simulation of expected losses are in good agreement with measurements for oscillating bunches and that the space resolution of the acquisition system used during the MD is about 10 ...

  13. Bronchoscopic diagnostic procedures and microbiological examinations in proving endobronchial tuberculosis.

    Science.gov (United States)

    Şimşek, Abdullah; Yapıcı, İlhami; Babalık, Mesiha; Şimşek, Zekiye; Kolsuz, Mustafa

    2016-01-01

    To determine the proportional distribution of endobronchial tuberculosis (EBTB) subtypes and to evaluate the types of bronchoscopic diagnostic procedures that can prove granulomatous inflammation. This was a retrospective study of 18 HIV-negative patients with biopsy-proven EBTB treated between 2010 and 2014. The most common EBTB subtypes, as classified by the bronchoscopic features, were tumorous and granular (in 22.2% for both). Sputum smear microscopy was performed in 11 patients and was positive for AFB in 4 (36.3%). Sputum culture was also performed in 11 patients and was positive for Mycobacterium tuberculosis in 10 (90.9%). Smear microscopy of BAL fluid (BALF) was performed in 16 patients and was positive for AFB in 10 (62.5%). Culture of BALF was also performed in 16 patients and was positive for M. tuberculosis in 15 (93.7%). Culture of BALF was positive for M. tuberculosis in 93.7% of the 16 patients tested. Among the 18 patients with EBTB, granulomatous inflammation was proven by the following bronchoscopic diagnostic procedures: bronchial mucosal biopsy, in 8 (44.4%); bronchial brushing, in 7 (38.8%); fine-needle aspiration biopsy, in 2 (11.1%); and BAL, in 2 (11.1%). Bronchial anthracofibrosis was observed in 5 (27.7%) of the 18 cases evaluated. In our sample of EBTB patients, the most common subtypes were the tumorous and granular subtypes. We recommend that sputum samples and BALF samples be evaluated by smear microscopy for AFB and by culture for M. tuberculosis, which could increase the rates of early diagnosis of EBTB. We also recommend that bronchial brushing be employed together with other bronchoscopic diagnostic procedures in patients suspected of having EBTB. Determinar a distribuição proporcional dos subtipos de tuberculose endobrônquica (TBEB) e avaliar os tipos de procedimentos diagnósticos broncoscópicos que podem revelar inflamação granulomatosa. Este foi um estudo retrospectivo com 18 pacientes HIV negativos com TBEB comprovada

  14. Multi-Device to Multi-Device (MD2MD Content-Centric Networking Based on Multi-RAT Device

    Directory of Open Access Journals (Sweden)

    Cheolhoon Kim

    2017-11-01

    Full Text Available This paper proposes a method whereby a device can transmit and receive information using a beacon, and also describes application scenarios for the proposed method. In a multi-device to multi-device (MD2MD content-centric networking (CCN environment, the main issue involves searching for and connecting to nearby devices. However, if a device can’t find another device that satisfies its requirements, the connection is delayed due to the repetition of processes. It is possible to rapidly connect to a device without repetition through the selection of the optimal device using the proposed method. Consequently, the proposed method and scenarios are advantageous in that they enable efficient content identification and delivery in a content-centric Internet of Things (IoT environment, in which multiple mobile devices coexist.

  15. Canal Creek Study Area, Aberdeen Proving Ground, Edgewood Area, Maryland. Groundwater Monitoring Plan, Final Health and Safety Plan

    Science.gov (United States)

    1993-10-01

    AýNL EE :>22020E 11N BREAST MILK dd. & ACCX2JSS5 PAGE 03 OF 06 * ~HEALTH EFFECTS AND FIRST AID I INHALATION; 1-ASCORBIC ACID: * ACUTE EXPOSURE...rJAOE’ UHTE EV1DEN-EA -iIMA 1NI-E E. ýL-N R ’RE RS jED 7,; - ), 4 ’Jh’ - THE S5 R-4i3 Jrr 15 J5 PRIZ’.: T - - - - - SLS itN N -L -S 4001>’ ’NAL C.A.T

  16. Operation IVY, Pacific Proving Grounds, November 1952. Project 11.5. Radiobiological Studies at Eniwetok before and after Mike Shot

    Science.gov (United States)

    1953-06-01

    8 0.3 2 Urchin and 0 0.2 2 4 4 4 1 0.3 0.02 3 sand dollar Cucumber 0 0.02 0.1 2 0.08 0.08 0.3 1 0.6 0.5 Crustacean 0 0.04 0.03 0.5 0.08 2 0.6 1...is to locality. Compari- son with 1949 findings at Eniwetok shows mutual tendencies toward high activities in samples of hydroids, sponges...Terns are not scavengers and do not eat refuse. The food of the shore birds is composed mostly of insects and small crustaceans found on the beaches

  17. Meeting on Solute/Solvent Interactions Held in Aberdeen Proving Ground, Maryland on May 29-30, 1991

    Science.gov (United States)

    1992-01-01

    0.55 6 Cysteine Ficin 1 0.57 6 Cysteine Ficin 1I 0.62 6 Cysteine Actinidin 1 0.74 6 Cysteine Bromelain B 1 0.70 6 Cys-Leine Bromelain B 1I 0.68 6...Cysteine Bromelain D 1 0.63 6 Cysteine Subtilisin 1 0.49 7 Serine Chymotrypsin 1 0.42 6.9 Serine Trypsin I Q21L 7 Serine Mean - 0.61 132 Table 11 Browse

  18. Celebrating Success: EPA Region 3 Greener Cleanup and Sustainable Reuse Award Winner: Aberdeen Proving Ground Federal Facility Superfund Site

    Science.gov (United States)

    Greener Cleanup practices were implemented as part of a successful Time-Critical Removal Action (TCRA) completed at the APG Former NIKE Missile Site which has resulted in a reduced environmental footprint, accelerated site closure, and a cost savings.

  19. MX Siting Investigation. Volume IIB. Geotechnical Report, Yuma Proving Grounds/Luke-Williams Bombing and Gunnery Range (YPG/LWBGR).

    Science.gov (United States)

    1975-06-30

    parallel or en echelon faults (Mattick and others, 1973) in the vicinity of the Algodones fault. Shallow exploratory trenching across the Algodones fault...a El cm a A CAMJ -*c F a w 0 -w *w 7 - a - D ina /5MO I MA, nc .MNTI 5 7. Ownership and Cultural Features The first two overlays show non-specific...States and Mexico . 2.1.2.2 Surface Water There are no known perennial surface water occurrences within the YPG/LWBGR boundaries (Shepard and others, 1955

  20. Focused Feasibility Study Final Health and Safety Plan. Beach Point Test Site, Aberdeen Proving Ground, Edgewood Area, Maryland.

    Science.gov (United States)

    1993-10-01

    bite thoroughly with an antiseptic and seek medical attention as soon as possible. The various stages and symptoms of both diseases are well recognized...the bite . The extremely painful characteristics of a pit viper bite (e.g., rattlesnake, copperhead) 4 include rapid swelling that can be identified...Recognition of Symptoms and Signs ........................... 3-7 0 3.1.2 Hazard Communication Program Procedures .......................... 3-7 3.1.3

  1. ESTCP Munitions Response Live Site Demonstrations Southwest Proving Ground, Arkansas Andersen Air Force Base, Guam Cost and Performance Report

    Science.gov (United States)

    2017-08-23

    Complete coverage of the demonstration site Footprint coverage calculated using UX-Process Footprint Coverage Quality Control (QC) tool; excludes...Complete coverage of the demonstration site Footprint coverage calculated using UX-Process Footprint Coverage QC tool; excludes inaccessible...installed  Vegetation thinned  IVS installation  37 seed items installed  Vegetation thinned  IVS installation Data Collection  11.23 acres

  2. 155-mm M795 Aerofuze Test at the KOFA Range, Yuma Proving Ground, Arizona, 19 May 2015

    Science.gov (United States)

    2017-09-01

    Monday, May 18, 2015, at gun location GP19-1 at YPG, a John Douglas Associates Decommutator/Breakout Box (JDA DECOM/BOB) was set up in the...DECOM lock was established and relayed to the gun crew before the round was screwed onto the projectile, which was the second M795 spotter round...during the 1BB test. The round was fired approximately 3:09 min later, and the signal lock was retained throughout 51 sec of flight until impact

  3. Health Risk Assessment of Consuming Deer from Aberdeen Proving Ground, Maryland. Report and Appendices A-D

    Science.gov (United States)

    1995-05-01

    acrocyanosis, angina pectoris, hypertension, myocardia! infarction, mesenicric thrombosis, systemic occlusive arterial disease, bronchiectasis, and...Columbia, MS. pp. 13-24. Borgono, J.M.; Vincent , P.; Venturino, H.; Infante, A. 1977. Arsenic in the drinking water of the city of Antofagast

  4. Beach Point Test Site, Aberdeen Proving Ground, Edgewood Area, Maryland. Focused Feasibility Study, Final Project Work Plan

    Science.gov (United States)

    1993-10-01

    tetrachloroethane, TCE, and PCE. Dithlane is an organosulfur compound usually associated with the degradation of mustard. Elevated levels of iron and...34 :!II S!.. I S , I all I -- 1.... 1.. ..... ...I .S, .. .. "•.,. N TABLE A-5 CONCENTRATIONS OF SEMIVOLATILE ORGANIC CONSTITUANTS AND ORGANOSULFUR

  5. Quality Control Methodologies for Advanced EMI Sensor Data Acquisition and Anomaly Classification - Former Southwestern Proving Ground, Arkansas

    Science.gov (United States)

    2015-07-01

    PERFORMING ORGANIZATION REPORT NUMBER Weston Solutions 1400 Weston Way West Chester, PA 19380 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10...centimeter DGM digital geophysical mapping DSB Defense Science Board EE /CA Engineering Evaluation/Cost Analysis EMI electromagnetic induction...presented in this section is taken from the Engineering Evaluation/Cost Analysis ( EE /CA) [1 and 2]. More details can be obtained in the EE /CA and in

  6. Electrothermal-Chemical Modeling Workshop, Held in Aberdeen Proving Ground, Maryland on 12-13 May 1993. Volume 1

    Science.gov (United States)

    1994-05-01

    141 PC 00 PCu PCU 6PC CPC PCU ~OWN 4E142 ZI POU) CICc S.•,p I I ’P I II P 04 3 143 "CBP EQUATIONS Ve-M ; - Vb =, .- -•)(1) z = 1 2pt 2 ZP 2 Z, - y (3...Phone: 813-578- 8239 Ft. Washington. PA 19034-3211 FAX: 813-578-8119 Phone: 215-542-1200 Mr. Michael Nusca Dr. C. -C Hsiao U.S. Army Research Laboratory

  7. 76 FR 7585 - General Motors Corporation Milford Proving Grounds Including On-Site Leased Workers From Adroit...

    Science.gov (United States)

    2011-02-10

    ... workers of Hewlett Packard formerly known as EDS, Global Product Development, Non-IT Business Development... Packard formerly known as EDS, Global Product Development, Non-IT Business Development Team and..., CDI Professional Services, Engineering Labs, Inc., Global Technology Associates, LTD., IAV Automotive...

  8. Increased release of sMD-2 during human endotoxemia and sepsis: a role for endothelial cells

    NARCIS (Netherlands)

    Wolfs, Tim G. A. M.; Dunn-Siegrist, Irène; van't Veer, Cornelis; Hodin, Caroline M. I. M.; Germeraad, Wilfred T. V.; van Zoelen, Marieke A. D.; van Suylen, Robert-Jan; Peutz-Kootstra, Carine J.; Elson, Greg; Pugin, Jérôme; Buurman, Wim A.

    2008-01-01

    MD-2 is the crucial cofactor of TLR4 in the detection of LPS. Here, we show that soluble MD-2 (sMD-2) circulates in plasma of healthy individuals as a polymeric protein. The total amount of sMD-2 in septic plasma was strongly elevated and contained both sMD-2 polymers and monomers, the latter

  9. An Apple Protein Kinase MdSnRK1.1 Interacts with MdCAIP1 to Regulate ABA Sensitivity.

    Science.gov (United States)

    Liu, Xiao-Juan; Liu, Xin; An, Xiu-Hong; Han, Peng-Liang; You, Chun-Xiang; Hao, Yu-Jin

    2017-10-01

    ABA is a crucial phytohormone for development and stress responses in plants. Snf1-related protein kinase 1.1 (SnRK1.1) is involved in the ABA response. However, the molecular mechanism underlying the SnRK1.1 response to ABA is largely unknown. Here, it was found that overexpression of the apple MdSnRK1.1 gene enhanced ABA sensitivity in both transgenic apple calli and Arabidopsis seedlings. Subsequently, a yeast two-hybrid screen demonstrated that MdCAIP1 (C2-domain ABA Insensitive Protein1) interacted with MdSnRK1.1. Their interaction was further confirmed by pull-down and co-immunoprecipitation assays. Expression of the MdCAIP1 gene was positively induced by ABA. Its overexpression enhanced ABA sensitivity in transgenic apple calli. Furthermore, it was found that MdSnRK1.1 phosphorylated the MdCAIP1 protein in vivo and promoted its degradation in vitro and in vivo. As a result, MdSnRK1.1 inhibited MdCAIP1-mediated ABA sensitivity, and MdCAIP1 partially reduced MdSnRK1.1-mediated ABA sensitivity. Our findings indicate that MdSnRK1.1 plays an important role in the ABA response, partially by controlling the stability of the MdCAIP1 protein. © The Author 2017. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  10. Validity of the Medical College Admission Test for Predicting MD-PhD Student Outcomes

    Science.gov (United States)

    Bills, James L.; VanHouten, Jacob; Grundy, Michelle M.; Chalkley, Roger; Dermody, Terence S.

    2016-01-01

    The Medical College Admission Test (MCAT) is a quantitative metric used by MD and MD-PhD programs to evaluate applicants for admission. This study assessed the validity of the MCAT in predicting training performance measures and career outcomes for MD-PhD students at a single institution. The study population consisted of 153 graduates of the…

  11. 77 FR 35054 - Donald Brooks Reece II, M.D.; Dismissal of Proceeding

    Science.gov (United States)

    2012-06-12

    ... Enforcement Administration Donald Brooks Reece II, M.D.; Dismissal of Proceeding On November 19, 2010, the... Order to Show Cause to Donald Brooks Reece II, M.D. (Respondent), of Morehead City, N.C. The Order... Donald Brooks Reece II, M.D., be, and it hereby is, dismissed. This Order is effective immediately. Dated...

  12. 75 FR 52461 - Drawbridge Operation Regulation; Pocomoke River, Snow Hill, MD

    Science.gov (United States)

    2010-08-26

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Pocomoke River, Snow Hill, MD AGENCY... the S12 ] Bridge across the Pocomoke River, mile 29.9, at Snow Hill, MD. The deviation restricts the... hours advance notice is given. The S12 Bridge across Pocomoke River, mile 29.9 at Snow Hill MD, has a...

  13. 77 FR 42464 - Special Local Regulations for Marine Events; Potomac River, National Harbor Access Channel, MD

    Science.gov (United States)

    2012-07-19

    ... River, National Harbor Access Channel, MD AGENCY: Coast Guard, DHS. ACTION: Proposed rule; withdrawal... ``Special Local Regulations for Marine Events; Potomac River, National Harbor Access Channel, MD'' in the... Channel, in Prince George's County, MD, effective from 5 a.m. until 11 a.m. on August 5, 2012. The...

  14. StandsSIM-MD: a Management Driven forest SIMulator

    Energy Technology Data Exchange (ETDEWEB)

    Barreiro, S.; Rua, J.; Tomé, M.

    2016-07-01

    Aim of the study. The existing stand level forest simulators available in Portugal were not developed with the aim of including up-to-date model versions and were limited in terms of accounting for forest management. The simulators’ platform, sIMfLOR was recently created to implement different growth models with a common philosophy. The objective was developing one easily-updatable, user-friendly, forest management and climate change sensitive simulator capable of projecting growth for the main tree species in Portugal. Area of the study: Portugal. Material and methods: The new simulator was programmed in a modular form consisting of several modules. The growth module integrates different forest growth and yield models (empirical and process-based) for the main wood production tree species in Portugal (eucalypt, umbrella and maritime pines); whereas the management module drives the growth projections along the planning horizon according to a range of forest management approaches and climate (at present only available for eucalypt). Main results: The main result is the StandsSIM-MD Management Driven simulator that overcomes the limitations of the existing stand level simulators. It is a step forward when compared to the models currently available in the sIMfLOR platform covering more tree species, stand structures and stand compositions. It is focused on end-users and it is based on similar concepts regarding the generation of required inputs and generated outputs. Research highlights: Forest Management Driven simulations approach. Multiple Prescriptions-Per-Stand functionality. StandsSIM-MD can be used to support landowners decisions on stand forest management. StandsSIM-MD simulations at regional level can be combined with optimization routines. (Author)

  15. Prompt neutron emission from the spontaneous fission of 260Md

    Science.gov (United States)

    Wild, J. F.; van Aarle, J.; Westmeier, W.; Lougheed, R. W.; Hulet, E. K.; Moody, K. J.; Dougan, R. J.; Koop, E.-A.; Glaser, R. E.; Brandt, R.; Patzelt, P.

    1990-02-01

    We have made the first measurement of the number of neutrons emitted from the spontaneous fission of a nuclide in which very high fragment energies dominate the fission process. In bombardments of 254Es, we produced a large sample of 28-d 260Md, which was neutron counted in a 1-m-diameter spherical tank containing a Gd-doped scintillator solution. The average number of neutrons emitted per fission is only 2.58+/-0.11, substantially less than for other actinides. A linear dependence of neutron multiplicity on fragment-excitation energy is observed to the highest values of total kinetic energy.

  16. 33 CFR 110.159 - Annapolis Harbor, MD.

    Science.gov (United States)

    2010-07-01

    ... Superintendent, U.S. Naval Academy. (2) Middle Ground Anchorage. Beginning at a point in the Severn River 139... Naval Academy grounds); thence easterly to a point 112°30′, 970 yards from Triton Light; thence... feet off the southeast seawall of the Naval Academy bearing 132° from Triton Light; thence easterly to...

  17. Quasiequivalence of multiscale coevolution and ensemble MD simulations: A demonstration with lactoferrin

    Science.gov (United States)

    Yang, J.; Singharoy, A.; Sereda, Yu. V.; Ortoleva, P. J.

    2014-11-01

    Ensemble molecular dynamics computations are performed because a single MD simulation may not represent all the possible scenarios. Ensemble MD consumes a great amount of resources. Here, the similarity of ensemble MD and coupled all-atom, coarse-grained simulation (the multiscale coevolution method) is assessed. Quasiequivalence of two simulations is defined and shown to provide a similarity measure. Quasiequivalence compares trajectories on coarse and relatively finer scales. Good agreement between multiscale coevolution and ensemble MD simulations is demonstrated for lactoferrin. Quasiequivalence along with greater CPU efficiencies of multiscale coevolution relative to ensemble MD, underscore the advantages of multiscale coevolution for nanosystem modeling.

  18. Harvey Cushing, M.D., in his world.

    Science.gov (United States)

    Hart, Curtis W

    2014-12-01

    Harvey Cushing, M.D. (1869-1939), is the acknowledged father of the discipline of neurosurgery who inspired others to join him in this new field. He was a prolific researcher in the area of human growth disturbances. And he was among the most literary of doctors having won the Pulitzer Prize for his two-volume biography of his mentor and teacher William Osler, M.D. A driven man, he both inspired and intimidated others. This essay explores Cushing's character and background along with his relationship to Osler. It seeks to understand why and how he may be considered a great figure in spite and because of his demanding and often problematic character. It further seeks to place Cushing in the context of the transition of American society and American medicine in the latter decades of the nineteenth and early decades of the twentieth century. Portions of this essay were originally delivered as part of a Grand Rounds presentation for the Department of Neurosurgery at the New York Presbyterian Hospital Weill Cornell Center.

  19. Full-Scale Crash Test of an MD-500 Helicopter

    Science.gov (United States)

    Littell, Justin

    2011-01-01

    A full-scale crash test was successfully conducted in March 2010 of an MD-500 helicopter at NASA Langley Research Center s Landing and Impact Research Facility. The reasons for conducting this test were threefold: 1 To generate data to be used with finite element computer modeling efforts, 2 To study the crashworthiness features typically associated with a small representative helicopter, and 3 To compare aircraft response to data collected from a previously conducted MD-500 crash test, which included an externally deployable energy absorbing (DEA) concept. Instrumentation on the airframe included accelerometers on various structural components of the airframe; and strain gages on keel beams, skid gear and portions of the skin. Three Anthropomorphic Test Devices and a specialized Human Surrogate Torso Model were also onboard to collect occupant loads for evaluation with common injury risk criteria. This paper presents background and results from this crash test conducted without the DEA concept. These results showed accelerations of approximately 30 to 50 g on the airframe at various locations, little energy attenuation through the airframe, and moderate to high probability of occupant injury for a variety of injury criteria.

  20. MD1878: Operation with primary collimators at tighter settings

    CERN Document Server

    AUTHOR|(CDS)2078850; Amorim, David; Biancacci, Nicolo; Bruce, Roderik; Buffat, Xavier; Carver, Lee Robert; Fiascaris, Maria; Mereghetti, Alessio; Redaelli, Stefano; Rossi, Roberto; Salvachua Ferrando, Belen Maria; Soderen, Martin; Trad, Georges; CERN. Geneva. ATS Department

    2017-01-01

    Primary (TCP) collimators of the betatron cleaning insertion determine the betatron cut of the LHC beam. During the 2016 they were set at 5.5 nominal beam sigmas at 6.5 TeV (i.e. by using a normalized emittance ε* = 3:5 μm is used). Reducing their settings is a possible way to push the ß* at the LHC, which depends on the collimation hierarchy. This study aims at understanding possible limitations of operating the LHC with tighter settings of the primary collimators. This is a crucial input to the choice of operational configuration in terms of ß* at the LHC as well as at the HL-LHC. This study follows a successful MD done in block 3 to understand limitations from TCP impedance [1]. The outcome of this MD can also have an impact for the design of the FCC collimation system, which is currently based on the present TCP gaps. Studies of beam stability as a function of octupole current, transverse feedback gain (ADT) and transverse separation at the IPs were also carried out.

  1. 'Grounded' Politics

    DEFF Research Database (Denmark)

    Schmidt, Garbi

    2012-01-01

    A prominent strand within current migration research argues that, to understand the participation of immigrants in their host societies, we must focus on their incorporation into the cities in which they settle. This article narrows the perspective further by focusing on the role that immigrants...... play within one particular neighbourhood: Nørrebro in the Danish capital, Copenhagen. The article introduces the concept of grounded politics to analyse how groups of Muslim immigrants in Nørrebro use the space, relationships and history of the neighbourhood for identity political statements...

  2. [Professor Frantisek Por MD and Professor Robert Klopstock MD, students at Budapest and Prague Faculties of Medicine].

    Science.gov (United States)

    Mydlík, M; Derzsiová, K

    2010-11-01

    Professor Frantisek Por MD and Professor Robert Klopstock MD were contemporaries, both born in 1899, one in Zvolen, the other in Dombovar, at the time of Austro-Hungarian Monarchy. Prof. Por attended the Faculty of Medicine in Budapest from 1918 to 1920, and Prof. Klopstock studied at the same place between 1917 and 1919. From 1920 until graduation on 6th February 1926, Prof. Por continued his studies at the German Faculty of Medicine, Charles University in Prague. Prof. Klopstock had to interrupt his studies in Budapest due to pulmonary tuberculosis; he received treatment at Tatranske Matliare where he befriended Franz Kafka. Later, upon Kafka's encouragement, he changed institutions and continued his studies at the German Faculty of Medicine, Charles University in Prague, where he graduated the first great go. It is very likely that, during their studies in Budapest and Prague, both professors met repeatedly, even though their life paths later separated. Following his graduation, Prof. Por practiced as an internist in Prague, later in Slovakia, and from 1945 in Kosice. In 1961, he was awarded the title of university professor of internal medicine at the Faculty of Medicine, Pavol Jozef Safarik University in Kosice, where he practiced until his death in 1980. Prof. Klopstock continued his studies in Kiel and Berlin. After his graduation in 1933, he practiced in Berlin as a surgeon and in 1938 left for USA. In 1962, he was awarded the title of university professor of pulmonary surgery in NewYork, where he died in 1972.

  3. Apple fruit copper amine oxidase isoforms: peroxisomal MdAO1 prefers diamines as substrates, whereas extracellular MdAO2 exclusively utilizes monoamines.

    Science.gov (United States)

    Zarei, Adel; Trobacher, Christopher P; Cooke, Alison R; Meyers, Ashley J; Hall, J Christopher; Shelp, Barry J

    2015-01-01

    4-Aminobutyrate (GABA) accumulates in apple fruit during controlled atmosphere storage. A potential source of GABA is the polyamine putrescine, which can be oxidized via copper-containing amine oxidase (CuAO), resulting in the production 4-aminobutanal/Δ(1)-pyrroline, with the consumption of O2 and release of H2O2 and ammonia. Five putative CuAO genes (MdAO genes) were cloned from apple (Malus domestica Borkh. cv. Empire) fruit, and the deduced amino acid sequences found to contain the active sites typically conserved in CuAOs. Genes encoding two of these enzymes, MdAO1 and MdAO2, were highly expressed in apple fruit and selected for further analysis. Amino acid sequence analysis predicted the presence of a C-terminal peroxisomal targeting signal 1 tripeptide in MdAO1 and an N-terminal signal peptide and N-glycosylation site in MdAO2. Transient expression of green fluorescent fusion proteins in Arabidopsis protoplasts or onion epidermal cells revealed a peroxisomal localization for MdAO1 and an extracellular localization for MdAO2. The enzymatic activities of purified recombinant MdAO1 and MdAO2 were measured continuously as H2O2 production using a coupled reaction. MdAO1 did not use monoamines or polyamines and displayed high catalytic efficiency for 1,3-diaminopropane, putrescine and cadaverine, whereas MdAO2 exclusively utilized aliphatic and aromatic monoamines, including 2-phenylethylamine and tyramine. Together, these results indicate that MdAO1 may contribute to GABA production via putrescine oxidation in the peroxisome of apple fruit under controlled atmosphere conditions. MdAO2 seems to be involved in deamination of 2-phenylethylamine, which is a step in the biosynthesis of 2-phenylethanol, a contributor to fruit flavor and flower fragrance. © The Author 2014. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  4. MD Simulation of Structural Transitions in Cristobalite Silica

    Science.gov (United States)

    Kieffer, John; Huang, Liping

    2001-03-01

    Molecular dynamics (MD) simulations, based on our charge-transfer potential, were used to simulate the phase transformation between alpha- and beta-cristobalite.* These simulations reveal the detailed transformation mechanism, in particular spatial correlations between transformed entities during incubation and progression of the transition. The transformation characteristics differ, depending on whether the transition is induced thermally or mechanically. The negative thermal expansion coefficient of beta-cristobalite has intriguing implications on the reverse transformation and the melting behavior of this substance. A better understanding of the thermo-mechanical anomalies of crystalline and amorphous silica is derived from careful analysis of the simulated atomic trajectories. * L. Duffrène and J. Kieffer, "Molecular Dynamic Simulations of the alpha-beta Phase Transition in Silica Cristobalite," J. Phys. Chem. Solids 59, 1025-1037 (1998)

  5. Medicinal Cannabis in California: An Interview with Igor Grant, MD.

    Science.gov (United States)

    Piomelli, Daniele; Grant, Igor

    2016-01-01

    Dr. Igor Grant, MD, is distinguished professor and chair of psychiatry and director of the HIV Neurobehavioral Research Program and the Center for Medicinal Cannabis Research at the University of California, San Diego. Dr. Grant is a neuropsychiatrist who graduated from the University of British Columbia School of Medicine (1966), and received specialty training in psychiatry at the University of Pennsylvania (1967-1971), and additional training in neurology at the Institute of Neurology (1980-1981), London, U.K. Dr. Grant's academic interests focus on the effects of various diseases on brain and behavior, with an emphasis on translational studies in HIV, and drugs of abuse. He has contributed to ∼700 scholarly publications and is principal investigator of several NIH studies, including an NIDA P50 (Translational Methamphetamine AIDS Research Center-TMARC), and is codirector of the HIV Neurobehavioral Research Center (HNRC).

  6. LHC β*-reach MD: aperture measurements at small β*

    CERN Document Server

    Fuster Martinez, Nuria; Redaelli, Stefano; CERN. Geneva. ATS Department

    2017-01-01

    During this MD, performed on the 25th of July 2017, we measured the LHC aperture at top energy for β*=30 cm using the Transverse Damper (ADT) blow-up method. These measurements are part of the standard commissioning of an optics and have been performed in order to provide early on inputs for a possible change of β* later in 2017, as envisaged previously to fully profit from the additional margins introduced by the rematched phase advance between dump kickers and the TCTs (Target Collimator Tertiary). In addition to the aperture measurements, two other commissioning important tests were performed: loss maps for the nominal TCTs settings and an asynchronous dump validation with tighter TCT gaps.

  7. MD 979: Beta-beating measurements on colliding beams

    CERN Document Server

    Goncalves Jorge, Patrik; Pieloni, Tatiana; Buffat, Xavier; Carlier, Felix Simon; Coello De Portugal - Martinez Vazquez, Jaime Maria; Fol, Elena; Langner, Andy Sven; Medina Medrano, Luis Eduardo; Olexa, Jakub; Tomas Garcia, Rogelio; Valuch, Daniel; Wegscheider, Andreas; CERN. Geneva. ATS Department

    2017-01-01

    The HL-LHC high brightness beams will give a large β-beating due to the head-on and long-range interactions since a beam-beam parameter of 0.01 per Interaction Point (IP) is expected. The β-heating induced by two head-on collision reaches 15%. A third IP, i.e. IP8, could bring the β-heating up to 24%. The aim of the Machine Development (MD) study was to test optics measurements with AC dipole and ADT on colliding beams at injection and to implement a correction of the β-heating due to to head-on collision in the two experiments IP1&5. Int his note, we summarize the first results of this test performed in the LHC.

  8. Impact of Carbon Nanotube on Homocysteine Clusters: MD Simulation

    Science.gov (United States)

    Raczyński, Przemysław; Górny, Krzysztof; Gburski, Zygmunt

    The role of homocysteine in the human body is not well known but its level is associated with cardiovascular disease. The pure clusters composed of n = 65 and 2500 homocysteine molecules have been studied by the computer simulation molecular dynamics (MD) method. Among the anticipated applications of the carbon nanotubes is their use in biological sensors, particularly homocysteine nanosensor. We have also examined the impact of a carbon nanotube on the homocysteine clusters. The mean square displacement, diffusion coefficient, and radial distribution function of homocysteine have been calculated for several temperatures, including the physiological (T = 310 K). We interpret the behavior of homocysteine molecules in the pure clusters and in the clusters with carbon nanotube by a qualitative interpretation of physical observables and snapshots of instantaneous configurations.

  9. Luminosity Anti-leveling with Crossing Angle (MD 1669)

    CERN Document Server

    Gorzawski, Arkadiusz; Ponce, Laurette; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; CERN. Geneva. ATS Department

    2016-01-01

    A significant fraction of the LHC luminosity ($\\sim$30\\% in 2016) is lost due to the presence (and necessity) of the crossing angles at the IPs. At the LHC the crossing angle is typically set to a value that provides sufficient separation of the beams at the start of fills for the peak bunch intensities. As the bunch intensity decays during a fill, it is possible to reduce the crossing angle and recover some luminosity. A smooth crossing angle reduction procedure must be developed to take advantage of this option during stable beam operation. During this MD a smooth procedure for luminosity leveling with crossing angle was tested. It was demonstrated that the orbit was well controlled, beam losses were low and the offset leveled experiments ALICE and LHCb were not affected by crossing angle leveling in ATLAS and CMS.

  10. Report from LHC MD 2158: IR-nonlinear studies

    CERN Document Server

    Maclean, Ewen Hamish; Dilly, Joschua Werner; Fol, Elena; Giovannozzi, Massimo; Hofer, Michael; Malina, Lukas; Persson, Tobias Hakan Bjorn; Coello De Portugal - Martinez Vazquez, Jaime Maria; Skowronski, Piotr Krzysztof; Tomas Garcia, Rogelio; Garcia-Tabares Valdivieso, Ana; Wegscheider, Andreas; CERN. Geneva. ATS Department

    2017-01-01

    For the first time the LHC is running for luminosity-production with local corrections for nonlinear errors in the ATLAS and CMS insertions. While a major step forward in LHC optics commissioning strategy (and one which has yielded clear operational benefits) considerable challenges remain to be overcome, both in regard to the optimization of LHC optics and in order to ensure successful commissioning of the High-Luminosity LHC. MD 2158 sought to follow up several aspects of the 2017 nonlinear optics commissioning which are not yet understood, and by enhancing sextupole and dodecapole sources in the ATLAS and CMS insertions explore the prospects for linear and nonlinear optics commissioning in the HL-LHC.

  11. A workshop on leadership for MD/PhD students.

    Science.gov (United States)

    Ciampa, Erin J; Hunt, Aubrey A; Arneson, Kyle O; Mordes, Daniel A; Oldham, William M; Vin Woo, Kel; Owens, David A; Cannon, Mark D; Dermody, Terence S

    2011-01-01

    Success in academic medicine requires scientific and clinical aptitude and the ability to lead a team effectively. Although combined MD/PhD training programs invest considerably in the former, they often do not provide structured educational opportunities in leadership, especially as applied to investigative medicine. To fill a critical knowledge gap in physician-scientist training, the Vanderbilt Medical Scientist Training Program (MSTP) developed a biennial two-day workshop in investigative leadership. MSTP students worked in partnership with content experts to develop a case-based curriculum and deliver the material. In its initial three offerings in 2006, 2008, and 2010, the workshop was judged by MSTP student attendees to be highly effective. The Vanderbilt MSTP Leadership Workshop offers a blueprint for collaborative student-faculty interactions in curriculum design and a new educational modality for physician-scientist training.

  12. A workshop on leadership for MD/PhD students

    Directory of Open Access Journals (Sweden)

    Mark D. Cannon

    2011-08-01

    Full Text Available Success in academic medicine requires scientific and clinical aptitude and the ability to lead a team effectively. Although combined MD/PhD training programs invest considerably in the former, they often do not provide structured educational opportunities in leadership, especially as applied to investigative medicine. To fill a critical knowledge gap in physician-scientist training, the Vanderbilt Medical Scientist Training Program (MSTP developed a biennial two-day workshop in investigative leadership. MSTP students worked in partnership with content experts to develop a case-based curriculum and deliver the material. In its initial three offerings in 2006, 2008, and 2010, the workshop was judged by MSTP student attendees to be highly effective. The Vanderbilt MSTP Leadership Workshop offers a blueprint for collaborative student-faculty interactions in curriculum design and a new educational modality for physician-scientist training.

  13. Grounded Intersectionality

    DEFF Research Database (Denmark)

    Marfelt, Mikkel Mouritz

    2016-01-01

    Purpose – The purpose of this paper is to build on contemporary intersectional literature to develop a grounded methodological framework for the study of social differences. Design/methodology/approach – A systematic literature review serves as the foundation for a discussion of the challenges...... associated with intersectional research. The findings assist in positioning the proposed methodological framework within recent intersectional debates. Findings – The review shows a rise in intersectional publications since the birth of the “intersectionality” term in 1989. Moreover, the paper points to four...... tensions within the field: a tension between looking at or beyond oppression; a tension between structural-oriented and process-oriented perspectives; an apparent incommensurability among the macro, meso, and micro levels of analysis; and a lack of coherent methodology. Research limitations...

  14. Plasticity and Failure in Nanocrystalline BCC Metals via MD Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Rudd, R E

    2010-02-12

    Advances in the ability to generate extremely high pressures in dynamic experiments such as at the National Ignition Facility has motivated the need for special materials optimized for those conditions as well as ways to probe the response of these materials as they are deformed. We need to develop a much deeper understanding of the behavior of materials subjected to high pressure, especially the effect of rate at the extremely high rates encountered in those experiments. Here we use large-scale molecular dynamics (MD) simulations of the high-rate deformation of nanocrystalline tantalum at pressures less than 100 GPa to investigate the processes associated with plastic deformation for strains up to 100%. We focus on 3D polycrystalline systems with typical grain sizes of 10-20 nm. We also study a rapidly quenched liquid (amorphous solid) tantalum. We apply a constant volume (isochoric), constant temperature (isothermal) shear deformation over a range of strain rates, and compute the resulting stress-strain curves to large strains for both uniaxial and biaxial compression. We study the rate dependence and identify plastic deformation mechanisms. The identification of the mechanisms is facilitated through a novel technique that computes the local grain orientation, returning it as a quaternion for each atom. This analysis technique is robust and fast, and has been used to compute the orientations on the fly during our parallel MD simulations on supercomputers. We find both dislocation and twinning processes are important, and they interact in the weak strain hardening in these extremely fine-grained microstructures. We also present some results on void growth in nanocrystalline BCC metals under tension.

  15. MD-TASK: a software suite for analyzing molecular dynamics trajectories.

    Science.gov (United States)

    Brown, David K; Penkler, David L; Sheik Amamuddy, Olivier; Ross, Caroline; Atilgan, Ali Rana; Atilgan, Canan; Tastan Bishop, Özlem

    2017-09-01

    Molecular dynamics (MD) determines the physical motions of atoms of a biological macromolecule in a cell-like environment and is an important method in structural bioinformatics. Traditionally, measurements such as root mean square deviation, root mean square fluctuation, radius of gyration, and various energy measures have been used to analyze MD simulations. Here, we present MD-TASK, a novel software suite that employs graph theory techniques, perturbation response scanning, and dynamic cross-correlation to provide unique ways for analyzing MD trajectories. MD-TASK has been open-sourced and is available for download from https://github.com/RUBi-ZA/MD-TASK , implemented in Python and supported on Linux/Unix. o.tastanbishop@ru.ac.za.

  16. Euthanasia: above ground, below ground.

    Science.gov (United States)

    Magnusson, R S

    2004-10-01

    The key to the euthanasia debate lies in how best to regulate what doctors do. Opponents of euthanasia frequently warn of the possible negative consequences of legalising physician assisted suicide and active euthanasia (PAS/AE) while ignoring the covert practice of PAS/AE by doctors and other health professionals. Against the background of survey studies suggesting that anything from 4% to 10% of doctors have intentionally assisted a patient to die, and interview evidence of the unregulated, idiosyncratic nature of underground PAS/AE, this paper assesses three alternatives to the current policy of prohibition. It argues that although legalisation may never succeed in making euthanasia perfectly safe, legalising PAS/AE may nevertheless be safer, and therefore a preferable policy alternative, to prohibition. At a minimum, debate about harm minimisation and the regulation of euthanasia needs to take account of PAS/AE wherever it is practised, both above and below ground.

  17. The power of ground user in recommender systems.

    Science.gov (United States)

    Zhou, Yanbo; Lü, Linyuan; Liu, Weiping; Zhang, Jianlin

    2013-01-01

    Accuracy and diversity are two important aspects to evaluate the performance of recommender systems. Two diffusion-based methods were proposed respectively inspired by the mass diffusion (MD) and heat conduction (HC) processes on networks. It has been pointed out that MD has high recommendation accuracy yet low diversity, while HC succeeds in seeking out novel or niche items but with relatively low accuracy. The accuracy-diversity dilemma is a long-term challenge in recommender systems. To solve this problem, we introduced a background temperature by adding a ground user who connects to all the items in the user-item bipartite network. Performing the HC algorithm on the network with ground user (GHC), it showed that the accuracy can be largely improved while keeping the diversity. Furthermore, we proposed a weighted form of the ground user (WGHC) by assigning some weights to the newly added links between the ground user and the items. By turning the weight as a free parameter, an optimal value subject to the highest accuracy is obtained. Experimental results on three benchmark data sets showed that the WGHC outperforms the state-of-the-art method MD for both accuracy and diversity.

  18. The power of ground user in recommender systems.

    Directory of Open Access Journals (Sweden)

    Yanbo Zhou

    Full Text Available Accuracy and diversity are two important aspects to evaluate the performance of recommender systems. Two diffusion-based methods were proposed respectively inspired by the mass diffusion (MD and heat conduction (HC processes on networks. It has been pointed out that MD has high recommendation accuracy yet low diversity, while HC succeeds in seeking out novel or niche items but with relatively low accuracy. The accuracy-diversity dilemma is a long-term challenge in recommender systems. To solve this problem, we introduced a background temperature by adding a ground user who connects to all the items in the user-item bipartite network. Performing the HC algorithm on the network with ground user (GHC, it showed that the accuracy can be largely improved while keeping the diversity. Furthermore, we proposed a weighted form of the ground user (WGHC by assigning some weights to the newly added links between the ground user and the items. By turning the weight as a free parameter, an optimal value subject to the highest accuracy is obtained. Experimental results on three benchmark data sets showed that the WGHC outperforms the state-of-the-art method MD for both accuracy and diversity.

  19. Analysis of MD5 authentication in various routing protocols using simulation tools

    Science.gov (United States)

    Dinakaran, M.; Darshan, K. N.; Patel, Harsh

    2017-11-01

    Authentication being an important paradigm of security and Computer Networks require secure paths to make the flow of the data even more secure through some security protocols. So MD-5(Message Digest 5) helps in providing data integrity to the data being sent through it and authentication to the network devices. This paper gives a brief introduction to the MD-5, simulation of the networks by including MD-5 authentication using various routing protocols like OSPF, EIGRP and RIPv2. GNS3 is being used to simulate the scenarios. Analysis of the MD-5 authentication is done in the later sections of the paper.

  20. Evidence for ProTα-TLR4/MD-2 binding: molecular dynamics and gravimetric assay studies.

    Science.gov (United States)

    Omotuyi, Olaposi; Matsunaga, Hayato; Ueda, Hiroshi

    2015-01-01

    During preconditioning, lipopolysaccharide (LPS) selectively activates TLR4/MD-2/Toll/IL-1 receptor-domain-containing adaptor inducing IFN-β (TRIF) pathway instead of pro-inflammatory myeloid differentiation protein-88 (MyD88)/MyD88-adaptor-like protein (MAL) pathway. Extracellular prothymosin alpha (ProTα) is also known to selectively activate the TLR4/MD2/TRIF-IRF3 pathway in certain diseased conditions. In the current study, biophysical evidence for ProTα/TLR4/MD-2 complex formation and its interaction dynamics have been studied. Gravimetric assay was used to investigate ProTα/TLR4/MD-2 complex formation while molecular dynamics (MD) simulation was used to study its interaction dynamics. Through electrostatic interaction, full-length ProTα (F-ProTα) C-terminal peptide (aa 91 - 111) superficially interacts with similar TLR4/MD-2 (KD = 273.36 nm vs 16.07 μg/ml [LPS]) conformation with LPS at an overlapping three-dimensional space while F-ProTα is hinged to the TLR4 scaffold by one-amino acid shift-Mosoian domain (aa-51 - 90). Comparatively, F-ProTα better stabilizes MD-2 metastable states transition and mediates higher TLR4/MD-2 interaction than LPS. ProTα via its C-terminal peptide (aa 91 - 111) exhibits in vitro biophysical contact with TLR4/MD-2 complex conformation recognized by LPS at overlapping LPS-binding positions.

  1. Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149

    Directory of Open Access Journals (Sweden)

    Rok Tkavc

    2018-01-01

    Full Text Available Highly concentrated radionuclide waste produced during the Cold War era is stored at US Department of Energy (DOE production sites. This radioactive waste was often highly acidic and mixed with heavy metals, and has been leaking into the environment since the 1950s. Because of the danger and expense of cleanup of such radioactive sites by physicochemical processes, in situ bioremediation methods are being developed for cleanup of contaminated ground and groundwater. To date, the most developed microbial treatment proposed for high-level radioactive sites employs the radiation-resistant bacterium Deinococcus radiodurans. However, the use of Deinococcus spp. and other bacteria is limited by their sensitivity to low pH. We report the characterization of 27 diverse environmental yeasts for their resistance to ionizing radiation (chronic and acute, heavy metals, pH minima, temperature maxima and optima, and their ability to form biofilms. Remarkably, many yeasts are extremely resistant to ionizing radiation and heavy metals. They also excrete carboxylic acids and are exceptionally tolerant to low pH. A special focus is placed on Rhodotorula taiwanensis MD1149, which was the most resistant to acid and gamma radiation. MD1149 is capable of growing under 66 Gy/h at pH 2.3 and in the presence of high concentrations of mercury and chromium compounds, and forming biofilms under high-level chronic radiation and low pH. We present the whole genome sequence and annotation of R. taiwanensis strain MD1149, with a comparison to other Rhodotorula species. This survey elevates yeasts to the frontier of biology's most radiation-resistant representatives, presenting a strong rationale for a role of fungi in bioremediation of acidic radioactive waste sites.

  2. Comparison of Basic Science Knowledge Between DO and MD Students.

    Science.gov (United States)

    Davis, Glenn E; Gayer, Gregory G

    2017-02-01

    With the coming single accreditation system for graduate medical education, medical educators may wonder whether knowledge in basic sciences is equivalent for osteopathic and allopathic medical students. To examine whether medical students' basic science knowledge is the same among osteopathic and allopathic medical students. A dataset of the Touro University College of Osteopathic Medicine-CA student records from the classes of 2013, 2014, and 2015 and the national cohort of National Board of Medical Examiners Comprehensive Basic Science Examination (NBME-CBSE) parameters for MD students were used. Models of the Comprehensive Osteopathic Medical Licensing Examination-USA (COMLEX-USA) Level 1 scores were fit using linear and logistic regression. The models included variables used in both osteopathic and allopathic medical professions to predict COMLEX-USA outcomes, such as Medical College Admission Test biology scores, preclinical grade point average, number of undergraduate science units, and scores on the NBME-CBSE. Regression statistics were studied to compare the effectiveness of models that included or excluded NBME-CBSE scores at predicting COMLEX-USA Level 1 scores. Variance inflation factor was used to investigate multicollinearity. Receiver operating characteristic curves were used to show the effectiveness of NBME-CBSE scores at predicting COMLEX-USA Level 1 pass/fail outcomes. A t test at 99% level was used to compare mean NBME-CBSE scores with the national cohort. A total of 390 student records were analyzed. Scores on the NBME-CBSE were found to be an effective predictor of COMLEX-USA Level 1 scores (PNBME-CBSE scores (PNBME-CBSE between osteopathic and allopathic medical students (P=.322). As an examination constructed to assess the basic science knowledge of allopathic medical students, the NBME-CBSE is effective at predicting performance on COMLEX-USA Level 1. In addition, osteopathic medical students performed the same as allopathic medical

  3. MD#1182: Calibration of diamond particle detectors in IP6

    CERN Document Server

    Valette, Matthieu; Lindstrom, Bjorn Hans Filip; Wiesner, Christoph

    2017-01-01

    In case of an asynchronous beam dump with a fully filled LHC machine it is expected that all standard ionisation chamber Beam Loss Monitors (IC BLM) around the LHC dumping region in IP6 will be saturated. Diamond Beam Loss Monitors (dBLM) were therefore installed next to the movable dump protection absorber (TCDQ) downstream of the extraction kickers. These detectors allow resolving losses at a nanosecond timescale and with an dynamic range of several orders of magnitude; thus, allowing to know the number of nominal bunches impacting the TCDQ. After a first series of calibrations using asynchronous beam dump tests, an experiment was conducted during MD#1182 to demonstrate the possibility of resolving a nominal bunch hitting the TCDQ. The impact parameter of the bunches on the TCDQ was first scanned using probe bunches with lower intensity then tests were done with nominal bunches (1.1e11 p/bunch) at injection energy. High energy calibration of the losses was also attempted unsuccessfully. Due to different beh...

  4. BayesMD: flexible biological modeling for motif discovery.

    Science.gov (United States)

    Tang, Man-Hung Eric; Krogh, Anders; Winther, Ole

    2008-12-01

    We present BayesMD, a Bayesian Motif Discovery model with several new features. Three different types of biological a priori knowledge are built into the framework in a modular fashion. A mixture of Dirichlets is used as prior over nucleotide probabilities in binding sites. It is trained on transcription factor (TF) databases in order to extract the typical properties of TF binding sites. In a similar fashion we train organism-specific priors for the background sequences. Lastly, we use a prior over the position of binding sites. This prior represents information complementary to the motif and background priors coming from conservation, local sequence complexity, nucleosome occupancy, etc. and assumptions about the number of occurrences. The Bayesian inference is carried out using a combination of exact marginalization (multinomial parameters) and sampling (over the position of sites). Robust sampling results are achieved using the advanced sampling method parallel tempering. In a post-analysis step candidate motifs with high marginal probability are found by searching among those motifs that contain sites that occur frequently. Thereby, maximum a posteriori inference for the motifs is avoided and the marginal probabilities can be used directly to assess the significance of the findings. The framework is benchmarked against other methods on a number of real and artificial data sets. The accompanying prediction server, documentation, software, models and data are available from http://bayesmd.binf.ku.dk/.

  5. Using MD Simulations To Calculate How Solvents Modulate Solubility.

    Science.gov (United States)

    Liu, Shuai; Cao, Shannon; Hoang, Kevin; Young, Kayla L; Paluch, Andrew S; Mobley, David L

    2016-04-12

    Here, our interest is in predicting solubility in general, and we focus particularly on predicting how the solubility of particular solutes is modulated by the solvent environment. Solubility in general is extremely important, both for theoretical reasons - it provides an important probe of the balance between solute-solute and solute-solvent interactions - and for more practical reasons, such as how to control the solubility of a given solute via modulation of its environment, as in process chemistry and separations. Here, we study how the change of solvent affects the solubility of a given compound. That is, we calculate relative solubilities. We use MD simulations to calculate relative solubility and compare our calculated values with experiment as well as with results from several other methods, SMD and UNIFAC, the latter of which is commonly used in chemical engineering design. We find that straightforward solubility calculations based on molecular simulations using a general small-molecule force field outperform SMD and UNIFAC both in terms of accuracy and coverage of the relevant chemical space.

  6. Page 1 238 S Kesavan 5. Conclusion It has been proved that non ...

    Indian Academy of Sciences (India)

    which has been used only to prove the existence of a solution via a priori estimates. Indeed this condition can be removed and replaced by any other which guarantees the existence of a non-singular solution of the homogenized problem alone. Then the method of this paper can be used to prove (without new hypotheses) ...

  7. 77 FR 5105 - Randall L. Wolff, M.D.; Decision and Order

    Science.gov (United States)

    2012-02-01

    ... February 1, 2012 Part III Department of Justice Drug Enforcement Administration Randall L. Wolff, M.D... / Notices#0;#0; ] DEPARTMENT OF JUSTICE Drug Enforcement Administration Randall L. Wolff, M.D.; Decision and... `` t was from football,'' that he had had back pain since ``98'' and that Dr. C. ``had it in my chart...

  8. Effectiveness of a clinical intervention for MD/PhD students re-entering medical school.

    Science.gov (United States)

    Bills, James L; Davidson, Mario; Dermody, Terence S

    2013-01-01

    For MD/PhD students, the transition to medical school following graduate research can be difficult. We developed a clinical intervention, the Clinical Preceptorship Program (CPP), for MD/PhD students at Vanderbilt to ease the transition to the core clinical clerkship year (the 3rd medical year) following graduate training. In this study, we determined whether the CPP prepared MD/PhD students adequately for medical school reentry. Clerkship grades were obtained for 680 medical students and 50 MD/PhD students for academic years 2004-2010. A student's unpaired t test was used to analyze differences between group grades. We did not detect significant differences in the grades of the MD versus MD/PhD students. No differences in individual clerkships were detected with the exception of the Surgery clerkship. These data suggest that the CPP intervention was successful in preparing MD/PhD students for the core clerkship year. Such a clinical intervention can be an effective preparation for MD/PhD students returning to medical school.

  9. Functional Characterization of the Apple RING E3 Ligase MdMIEL1 in Transgenic Arabidopsis

    Directory of Open Access Journals (Sweden)

    Jianping AN

    2017-03-01

    Full Text Available E3 ubiquitin ligases are involved in various physiological processes, and they play pivotal roles in growth and development. In this study, we identified a previously unknown gene in the apple fruit (Malus × domestica and named it MdMIEL1. The MdMIEL1 gene encoded a protein that contained a zinc-finger domain at its N-terminus and a RING-finger motif at its C-terminus. To investigate MdMIEL1 functions, we generated transgenic Arabidopsis lines expressing the MdMIEL1 gene under the control of the Cauliflower mosaic virus 35S promoter. Interestingly, ectopic expression of MdMIEL1 in Arabidopsis produced multiple phenotypes, including early germination, early flowering and a lateral root number increase relative to wild-type plants. Further analysis indicated that MdMIEL1 regulated lateral root initiation by increasing auxin accumulation in the roots. In a word, these results suggest that, MdMIEL1 as a novel RING-finger ubiquitin ligase influences plant growth and development, and highlight that MdMIEL1 regulates lateral root growth.

  10. 76 FR 48898 - Robert Leigh Kale, M.D., Decision and Order

    Science.gov (United States)

    2011-08-09

    ... Enforcement Administration Robert Leigh Kale, M.D., Decision and Order On September 9, 2010, the Deputy... Show Cause to Robert Leigh Kale, M.D. (Registrant), of Fort Smith, Arkansas. ] The Show Cause Order....100(b) and 0.104, I order that DEA Certificate of Registration, BK9514375, issued to Robert Leigh Kale...

  11. 76 FR 16296 - Drawbridge Operation Regulation; Pocomoke River, Snow Hill, MD

    Science.gov (United States)

    2011-03-23

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Pocomoke River, Snow Hill, MD AGENCY... the S12 Bridge across Pocomoke River, mile 29.9, at Snow Hill, MD. The deviation restricts the... least five hours advance notice is given. The S12 Bridge across Pocomoke River, mile 29.9 at Snow Hill...

  12. 78 FR 38000 - Special Local Regulations; Marine Events, Spa Creek and Annapolis Harbor; Annapolis, MD

    Science.gov (United States)

    2013-06-25

    ...--AA08 Special Local Regulations; Marine Events, Spa Creek and Annapolis Harbor; Annapolis, MD AGENCY...,'' a marine event to be held on the waters of Spa Creek and Annapolis Harbor on July 20, 2013. The...; Marine Events, Spa Creek and Annapolis Harbor; Annapolis, MD'' in the Federal Register (78 FR 20066). The...

  13. Educational views and attitudes, and career goals of MD-PhD students at the University of Pennsylvania School of Medicine.

    Science.gov (United States)

    Watt, Christopher D; Greeley, Siri Atma W; Shea, Judy A; Ahn, Jaimo

    2005-02-01

    Despite the documented contribution of graduates of MD-PhD programs to the medical profession, few data exist concerning the views, attitudes, and career goals of students before they graduate from such programs. All 167 students enrolled in the University of Pennsylvania School of Medicine Combined Degree Program in the spring of 2002 were invited to participate in an IRB-approved online questionnaire consisting of 81 multiple-choice questions covering students' demographics, satisfaction with their educational experience, future goals and career aspirations, and attitudes and views concerning the physician-scientist model. The 96 MD-PhD students (57.5%) who completed the questionnaire represented a diverse group with individuals from every stage of training. The majority of students were satisfied with their overall educational experience (90.5%). Although students reported an interest in a wide range of clinical specialties, 84.4% indicated plans to pursue a career in research and 79.2% preferred a position at an academic medical center. However, a larger percentage of males (70.7%) than females (50.0%) listed research as their primary professional activity. The range of students' views and attitudes regarding the physician-scientist model suggests that additional education and discussion are warranted. The MD-PhD students surveyed at the University of Pennsylvania were satisfied with their education and most were planning research-oriented careers. Yet, the aspirations, views and concerns of individual MD-PhD students were varied. The authors believe this information in aggregate will prove useful to current and future students, combined degree programs, policymakers, and residency directors.

  14. Classificació de proves no paramètriques. Com aplicar-les en SPSS

    Directory of Open Access Journals (Sweden)

    Vanesa Berlanga-Silvente

    2012-07-01

    Full Text Available Les proves no paramètriques engloben una sèrie de proves estadístiques, que tenen com a denominador comú l'absència de assumpcions sobre la llei de probabilitat que segueix la població de la qual ha estat extreta la mostra. Per aquesta raó és comú referir-s'hi com a proves de distribució lliure. A l'article es descriuen i treballen les proves no paramètriques ressaltant el seu fonament i les indicacions per al seu ús quan es tracta d'una sola mostra (Chi-quadrat, de dues mostres amb dades independents (U de Mann-Whitney, de dues mostres amb dades relacionades (T de Wilcoxon, de diverses mostres amb dades independents (H de Kruskal-Wallis i de diverses mostres amb dades relacionades (Friedman.

  15. PROVE GOES-8 Images of Jornada Experimental Range, New Mexico, 1997

    Data.gov (United States)

    National Aeronautics and Space Administration — As part of the Prototype Validation Experiment (PROVE) at the Jornada Experimental Range, GOES-8 images were collected every 30 minutes for 15 days overlapping the...

  16. PROVE Land Cover and Leaf Area of Jornada Experimental Range, New Mexico, 1997

    Data.gov (United States)

    National Aeronautics and Space Administration — Field measurement of shrubland ecological properties is important for both site monitoring and validation of remote-sensing information. During the PROVE exercise on...

  17. Hygrosopicity measurements of aerosol particles in the San Joaquin Valley, CA, Baltimore, MD, and Golden, CO

    Science.gov (United States)

    Orozco, Daniel; Beyersdorf, A. J.; Ziemba, L. D.; Berkoff, T.; Zhang, Q.; Delgado, R.; Hennigan, C. J.; Thornhill, K. L.; Young, D. E.; Parworth, C.; Kim, H.; Hoff, R. M.

    2016-06-01

    Aerosol hygroscopicity was investigated using a novel dryer-humidifier system, coupled to a TSI-3563 nephelometer, to obtain the light scattering coefficient (σscat) as a function of relative humidity (RH) in hydration and dehydration modes. The measurements were performed in Porterville, CA (10 January to 6 February 2013), Baltimore, MD (3-30 July 2013), and Golden, CO (12 July to 10 August 2014). Observations in Porterville and Golden were part of the NASA-sponsored Deriving Information on Surface Conditions from Column and Vertically Resolved Observations Relevant to Air Quality project. The measured σscat under varying RH in the three sites was combined with ground aerosol extinction, PM2.5 mass concentrations, and particle composition measurements and compared with airborne observations performed during campaigns. The enhancement factor, f(RH), defined as the ratio of σscat(RH) at a certain RH divided by σscat at a dry value, was used to evaluate the aerosol hygroscopicity. Particles in Porterville showed low average f(RH = 80%) (1.42) which was attributed to the high carbonaceous loading in the region where residential biomass burning and traffic emissions contribute heavily to air pollution. In Baltimore, the high average f(RH = 80%) (2.06) was attributed to the large contribution of SO42- in the region. The lowest water uptake was observed in Golden, with an average f(RH = 80%) = 1.24 where organic carbon dominated the particle loading. Different empirical fits were evaluated using the f(RH) data. The widely used Kasten (gamma) model was found least satisfactory, as it overestimates f(RH) for RH < 75%. A better empirical fit with two power law curve fitting parameters c and k was found to replicate f(RH) accurately from the three sites. The relationship between the organic carbon mass and the species that are affected by RH and f(RH) was also studied and categorized.

  18. The Development of the Proving Process Within a Dynamic Geometry Environment

    Directory of Open Access Journals (Sweden)

    Danh Nam Nguyen

    2012-10-01

    Full Text Available In this paper we classify student’s proving level and design an interactive help system (IHS corresponding with these levels in order to investigate the development of the proving process within a dynamic geometry environment. This help system was also used to provide tertiary students with a strategy for proving and to improve their proving levels. The open-ended questions and explorative tasks in the IHS make a contribution to support students’ learning of proving, especially during the processes of realizing invariants, formulating conjectures, producing arguments, and writing proofs. This research wants to react on the well-known students’ difficulties in writing a formal proof. The hypothesis of this work is that these difficulties are based on the lack of students’ understanding the relationship between argumentation and proof. Therefore, we used Toulmin model to analyze student’s argumentation structure and examine the role of abduction in writing a deductive proof. Furthermore, this paper also provides mathematics teachers with three basic conditions for understanding the development of the proving process and teaching strategies for assisting their students in constructing formal proofs.

  19. The core competencies of James Marion Sims, MD.

    Science.gov (United States)

    Straughn, J Michael; Gandy, Roy E; Rodning, Charles B

    2012-07-01

    The concept of core competencies in graduate medical education was introduced by the Accreditation Council for Graduate Medical Education of the American Medical Association to semiquantitatively assess the professional performance of students, residents, practitioners, and faculty. Many aspects of the career of J. Marion Sims, MD, are exemplary of those core competencies: MEDICAL KNOWLEDGE: Author of the first American textbook related to gynecology. MEDICAL CARE: Innovator of the Sims' Vaginal Speculum, Sims' Position, Sims' Test, and vesico-/rectovaginal fistulorrhaphy; advocated abdominal exploration for penetrating wounds; performed the first cholecystostomy. PROFESSIONALISM: Served as President of the New York Academy of Medicine, the American Medical Association, and the American Gynecologic Society. INTERPERSONAL RELATIONSHIPS/COMMUNICATION: Cared for the indigent, hearthless, indentured, disenfranchised; served as consulting surgeon to the Empress Eugénie (France), the Duchess of Hamilton (Scotland), the Empress of Austria, and other royalty of the aristocratic Houses of Europe; accorded the National Order of the Legion of Honor. PRACTICE-BASED LEARNING: Introduction of silver wire sutures; adoption of the principles of asepsis/antisepsis; adoption of the principles of general anesthesia. SYSTEMS-BASED PRACTICE: Established the Woman's Hospital, New York City, New York, the predecessor of the Memorial Sloan-Kettering Center for the Treatment of Cancer and Allied Diseases; organized the Anglo-American Ambulance Corps under the patronage of Napoleon III. What led him to a life of clinical and humanitarian service? First, he was determined to succeed. His formal medical/surgical education was perhaps the best available to North Americans during that era. Second, he was courageous in experimentation and innovation, applying new developments in operative technique, asepsis/antisepsis, and general anesthesia. Third, his curiosity was not burdened by rigid

  20. Milestone report on MD potential development for uranium silicide

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Jianguo [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.; Zhang, Yongfeng [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.; Hales, Jason Dean [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.

    2016-03-01

    This report summarizes the progress on the interatomic potential development of triuranium-disilicide (U3Si2) for molecular dynamics (MD) simulations. The development is based on the Tersoff type potentials for single element U and Si. The Si potential is taken from the literature and a Tersoff type U potential is developed in this project. With the primary focus on the U3Si2 phase, some other U-Si systems such as U3Si are also included as a test of the transferability of the potentials for binary U-Si phases. Based on the potentials for unary U and Si, two sets of parameters for the binary U-Si system are developed using the Tersoff mixing rules and the cross-term fitting, respectively. The cross-term potential is found to give better results on the enthalpy of formation, lattice constants and elastic constants than those produced by the Tersoff mixing potential, with the reference data taken from either experiments or density functional theory (DFT) calculations. In particular, the results on the formation enthalpy and lattice constants for the U3Si2 phase and lattice constants for the high temperature U3Si (h-U3Si) phase generated by the cross-term potential agree well with experimental data. Reasonable agreements are also reached on the elastic constants of U3Si2, on the formation enthalpy for the low temperature U3Si (m-U3Si) and h-U3Si phases, and on the lattice constants of m-U3Si phase. All these phases are predicted to be mechanically stable. The unary U potential is tested for three metallic U phases (α, β, γ). The potential is found capable to predict the cohesive energies well against experimental data for all three phases. It matches reasonably with previous experiments on the lattice constants and elastic constants of αU.

  1. Characterization of an Autophagy-related Gene MdATG8i from apple

    Directory of Open Access Journals (Sweden)

    Ping eWang

    2016-05-01

    Full Text Available Nutrient deficiencies restrict apple (Malus sp. tree growth and productivity in Northwest China. The process of autophagy, a conserved degradation pathway in eukaryotic cells, has important roles in nutrient-recycling and helps improve plant performance during periods of nutrient-starvation. Little is known about the functioning of autophagy-related genes (ATGs in apple. In this study, one of the ATG8 gene family members MdATG8i was isolated from M. domestica. MdATG8i has conserved putative tubulin binding sites and ATG7 interaction domains. A 1865-bp promoter region cloned from apple genome DNA was predicated to have cis-regulatory elements responsive to light, environmental stresses and hormones. MdATG8i transcriptions were induced in response to leaf senescence, nitrogen depletion, and oxidative stress. At cellular level, MdATG8i protein was expressed in the nucleus and cytoplasm of onion epidermal cells. Yeast two-hybrid tests showed that MdATG8i could interact with MdATG7a and MdATG7b. In Arabidopsis, its heterologous expression was associated with enhanced vegetative growth, leaf senescence, and tolerance to nitrogen- and carbon-starvation. MdATG8i-overexpressing ‘Orin’ apple callus lines also displayed improved tolerance to nutrient-limited conditions. Our results demonstrate that MdATG8i protein could function in autophagy in a conserved way, as a positive regulator in the response to nutrient-starvation.

  2. Molecular Cloning and Expression Analysis of a Hexokinase Gene, MdHXK1 in Apple

    Directory of Open Access Journals (Sweden)

    Jin Zhao

    2016-03-01

    Full Text Available A hexokinase gene named MdHXK1 (MDP0000309677 was cloned from ‘Gala’ apple (Malus × domestica Borkh.. Sequence analysis showed that the MdHXK1 gene was 1 497 bp long and encoded 499 amino acids. The predicted molecular mass of this protein was 54.05 kD, and the pI was 5.76. A phylogenetic tree indicated apple MdHXK1 exhibited the highest sequence similarity to Pyrus bretschneideri PbHXK1. Analysis of the functional domain showed that the MdHXK1 protein included two conserved kinase domains. The prediction of subcellular localization suggested that the MdHXK1 protein was mainly localized in the cytoplasm. There was an indication that MdHXK1 existed as one copy in the apple genome by Southern blotting. Silico analysis suggested that the promoter sequence contained several typical cis-acting elements, including defense, sugar signaling and phytohormone responsive elements. Quantitative real-time PCR analysis demonstrated that the MdHXK1 gene was mainly expressed in stem and flower tissues. During the development of apple fruits, the expression of the MdHXK1 gene initially increased and then decreased. The changes on Glc phosphorylation relative activity and glucose concentration showed the same trend. In addition, the expression of this gene was induced by salt stress, low temperature, and abscisic acid (ABA. Finally, we obtained and purified the fused MdHXK1 protein by recombinant prokaryotic expression. Studies have demonstrated that MdHXK1 may participate in sugar metabolism in apple fruits. Enzyme encoded by MdHXK1 is a key factor in the mediation of sugar accumulation. Recently, researchers on hexokinase at home and abroad mainly focused on model plants, such as Arabidopsis, tobacco and rice, but orchard fruit like apple were underresearched. Our research established the foundation for the further study of the functions of MdHXK1.

  3. MD 2485: Active halo control using narrowband and colored noise excitations

    CERN Document Server

    Garcia Morales, Hector; Kotzian, Gerd; Maclean, Ewen Hamish; Redaelli, Stefano; Valuch, Daniel; Wagner, Joschka; CERN. Geneva. ATS Department

    2018-01-01

    This MD note summarizes the actions carried out during the MD 2485 on Active halo control using narrowband and colored noise excitations. The goal of the MD was to repeat some promising cases already tested in the past and introduce a new excitation type based on applying a colored noise. Although we were able to repeat some cases using a narrowband excitation, due to a problem with the waveform generator, the colored noise excitation could not be accomplished as expected. In any case, we provide some results that may be useful for future MDs.

  4. Osmotically and thermally isolated forward osmosis-membrane distillation (fo-md) integrated module for water treatment applications

    KAUST Repository

    Ghaffour, Noreddine

    2016-09-01

    An integrated forward osmosis-membrane distillation (FO-MD) module and systems and methods incorporating the module is disclosed providing higher efficiencies and using less energy. The FO-MD module is osmotically and thermally isolated. The isolation can prevent mixing of FO draw solution/FO permeate and MD feed, and minimize dilution of FO draw solution and cooling of MD feed. The module provides MD feed solution and FO draw solution streams that flow in the same module but are separated by an isolation barrier. The osmotically and thermally isolated FO-MD integrated module, systems and methods offer higher driving forces of both FO and MD processes, higher recovery, and wider application than previously proposed hybrid FO- MD systems.

  5. Ground states of linearly coupled Schrodinger systems

    Directory of Open Access Journals (Sweden)

    Haidong Liu

    2017-01-01

    Full Text Available This article concerns the standing waves of a linearly coupled Schrodinger system which arises from nonlinear optics and condensed matter physics. The coefficients of the system are spatially dependent and have a mixed behavior: they are periodic in some directions and tend to positive constants in other directions. Under suitable assumptions, we prove that the system has a positive ground state. In addition, when the L-infinity-norm of the coupling coefficient tends to zero, the asymptotic behavior of the ground states is also obtained.

  6. 75 FR 68970 - Amendment of Using Agency for Restricted Areas R-4002, R-4005, R-4006 and R-4007; MD

    Science.gov (United States)

    2010-11-10

    ... Restricted Areas R-4002, R-4005, R- 4006 and R-4007; MD AGENCY: Federal Aviation Administration (FAA), DOT... restricted areas R-4002, Bloodsworth Island, MD; and R-4005, R-4006 and R-4007, Patuxent River, MD to ``U.S... areas R-4002, R-4005, R-4006 and R-4007 in Maryland, in order to reflect the correct organization...

  7. Ground water and energy

    Energy Technology Data Exchange (ETDEWEB)

    1980-11-01

    This national workshop on ground water and energy was conceived by the US Department of Energy's Office of Environmental Assessments. Generally, OEA needed to know what data are available on ground water, what information is still needed, and how DOE can best utilize what has already been learned. The workshop focussed on three areas: (1) ground water supply; (2) conflicts and barriers to ground water use; and (3) alternatives or solutions to the various issues relating to ground water. (ACR)

  8. Metabolic engineering of apple by overexpression of the MdMyb10 gene

    Directory of Open Access Journals (Sweden)

    Khaled A.L. Rihani

    2017-06-01

    In the present study, the flavonoid pathway was successfully modified in apple by overexpressing the MdMyb10 transcription factor to validate the hypothesis of increased effect on plant disease resistance.

  9. 78 FR 62678 - Morris W. Cochran, M.D.; Decision and Order

    Science.gov (United States)

    2013-10-22

    ... conference with the parties, that he had intended to write May 17, 2013, rather than May 17, 2012, in the... plenary, administrative hearing. See Larry Elbert Perry, M.D., 77 FR 67,671 (DEA 2012); Treasure Coast...

  10. A Mathematic Model That Describes Modes of MdSGHV Transmission within House Fly Populations

    Directory of Open Access Journals (Sweden)

    Celeste R. Vallejo

    2013-11-01

    Full Text Available In this paper it is proposed that one potential component by which the Musca domestica salivary gland hypertrophy virus (MdSGHV infects individual flies is through cuticular damage. Breaks in the cuticle allow entry of the virus into the hemocoel causing the infection. Male flies typically have a higher rate of infection and a higher rate of cuticular damage than females. A model for the transmission of MdSGHV was formulated assuming several potential and recognized means of transmission. The model yields results that are in agreement with field data that measured the infection rate in house flies on dairy farms in Florida. The results from this model indicate that MdSGHV will be maintained at a stable rate within house fly populations and support the future use of MdSGHV as a birth control agent in house fly management.

  11. 77 FR 39630 - Special Local Regulations for Marine Events; Potomac River, National Harbor Access Channel, MD

    Science.gov (United States)

    2012-07-05

    ... Harbor Access Channel, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast... and National Harbor Access Channel during the event. DATES: This rule is effective on July 8, 2012... ``Special Local Regulations for [[Page 39631

  12. Summary of LHC MD 369: DOROS vs WBTN in IR Stripline BPMs

    CERN Document Server

    Draskovic, Drasko; Calvo Giraldo, Eva; Olexa, Jakub; Gasior, Marek; CERN. Geneva. ATS Department

    2015-01-01

    The aim of this MD is to quantify the impact of the stripline beam position monitor (BPM) directivity with two acquisition chain electronics systems, WBTN (Wide Band Time Normalizer) and DOROS (Diode ORbit and Oscillation System). This impact depends on the relative position and intensity of the two beams at the location of the monitor. This note explains all the procedures of the LHC MD 369, which took place on 20/07/2015 and presents the obtained results.

  13. Image fusion in craniofacial virtual reality modeling based on CT and 3dMD photogrammetry.

    Science.gov (United States)

    Xin, Pengfei; Yu, Hongbo; Cheng, Huanchong; Shen, Shunyao; Shen, Steve G F

    2013-09-01

    The aim of this study was to demonstrate the feasibility of building a craniofacial virtual reality model by image fusion of 3-dimensional (3D) CT models and 3 dMD stereophotogrammetric facial surface. A CT scan and stereophotography were performed. The 3D CT models were reconstructed by Materialise Mimics software, and the stereophotogrammetric facial surface was reconstructed by 3 dMD patient software. All 3D CT models were exported as Stereo Lithography file format, and the 3 dMD model was exported as Virtual Reality Modeling Language file format. Image registration and fusion were performed in Mimics software. Genetic algorithm was used for precise image fusion alignment with minimum error. The 3D CT models and the 3 dMD stereophotogrammetric facial surface were finally merged into a single file and displayed using Deep Exploration software. Errors between the CT soft tissue model and 3 dMD facial surface were also analyzed. Virtual model based on CT-3 dMD image fusion clearly showed the photorealistic face and bone structures. Image registration errors in virtual face are mainly located in bilateral cheeks and eyeballs, and the errors are more than 1.5 mm. However, the image fusion of whole point cloud sets of CT and 3 dMD is acceptable with a minimum error that is less than 1 mm. The ease of use and high reliability of CT-3 dMD image fusion allows the 3D virtual head to be an accurate, realistic, and widespread tool, and has a great benefit to virtual face model.

  14. Formalizing and proving a typing result for security protocols in Isabelle/HOL

    DEFF Research Database (Denmark)

    Hess, Andreas Viktor; Modersheim, Sebastian

    2017-01-01

    or the positive output of a verification tool. However several of these works have used a typed model, where the intruder is restricted to "well-typed" attacks. There also have been several works that show that this is actually not a restriction for a large class of protocols, but all these results so far...... are again pen-and-paper proofs. In this work we present a formalization of such a typing result in Isabelle/HOL. We formalize a constraint-based approach that is used in the proof argument of such typing results, and prove its soundness, completeness and termination. We then formalize and prove the typing...... result itself in Isabelle. Finally, to illustrate the real-world feasibility, we prove that the standard Transport Layer Security (TLS) handshake satisfies the main condition of the typing result....

  15. Sustainable water recovery from oily wastewater via forward osmosis-membrane distillation (FO-MD).

    Science.gov (United States)

    Zhang, Sui; Wang, Peng; Fu, Xiuzhu; Chung, Tai-Shung

    2014-04-01

    This study proposed and investigated a hybrid forward osmosis - membrane distillation (FO-MD) system for sustainable water recovery from oily wastewater by employing lab-fabricated FO and MD hollow fiber membranes. Stable oil-in-water emulsions of different concentrations with small droplet sizes (wastewater containing petroleum, surfactant, NaCl and acetic acid at 60 °C in the batch mode. The water flux in FO undergoes three-stage decline due to fouling and reduction in osmotic driving force, but is quite stable in MD regardless of salt concentration. Oily wastewater with relatively high salinity could be effectively recovered by the FO-MD hybrid system while maintaining large water flux, at least 90% feed water recovery could be readily attained with only trace amounts of oil and salts, and the draw solution was re-generated for the next rounds of FO-MD run. Interestingly, significant amount of acetic acid was also retained in the permeate for further reuse as a chemical additive during the production of crude oil. The work has demonstrated that not only water but also organic additives in the wastewater could be effectively recovered by FO-MD systems for reuse or other utilizations. Copyright © 2014 Elsevier Ltd. All rights reserved.

  16. Cell lines, Md108 and Md66, from the hemocytes of Malacosoma disstria (Lepidoptera) display aspects of plasma-free innate non-self activities.

    Science.gov (United States)

    Lapointe, Jason F; Dunphy, Gary B; Giannoulis, Paschalis; Mandato, Craig A; Nardi, James B; Gharib, Osama H; Niven, Donald F

    2011-11-01

    The innate non-self response systems of the deciduous tree pest, the forest tent caterpillar, Malacosoma disstria has been documented by us in terms of in vitro and in vivo reactions towards the Gram-positive nonpathogenic bacterium, Bacillus subtilis and Gram-negative pathogenic microbe, Xenorhabdus nematophila and their respective surface antigens, lipopoteichoic acids (LTA) and lipopolysaccharides (LPS). These studies, often conducted in whole and diluted hemolymph, preclude examination of plasma-free cellular (hemocyte) responses. Plasma-free hemocytes as primary cultures are difficult to obtain. The floating cell line Md66 and attached cell line Md108 from M. disstria hemocytes were examined as a model for plasma-free M. disstria hemocyte non-self responses. Herein, it was established that although both lines differed from each other and from the primary hemocyte cultures of M. disstria in growth parameters, cell composition and sizes both cell lines displayed granular cell-like (GL) cells and plasmatocyte-like (PL) cells according to morphological criteria and to some extent antigenic similarities based on labeling with anti-Chrysodeixis includens hemocyte monoclonal antibodies. Hemocyte-specific neuroglian-like protein was detected on cells of both cell lines and in the primary hemocyte cultures albeit with staining patterns differing according to culture and cell types, confluency levels and cell-cell adhesion. Both cell lines bound B. subtilis and X. nematophila, the reaction extent varying with the cell line and its cell types. LPS damaged both cell types in the two cell lines whereas LTA enhanced the adhesion of Md66 GL cells to flask surfaces followed by PL cell adhesion. PL cells of both lines, like the primary cultures, phagocytosed FITC-labeled B. subtilis; only Md108 GL cells phagocytosed B. subtilis. In either case phagocytosis was always less in frequency and intensity than the primary cultures. Proteins released from the cell lines differed in

  17. MdCOP1 Ubiquitin E3 Ligases Interact with MdMYB1 to Regulate Light-Induced Anthocyanin Biosynthesis and Red Fruit Coloration in Apple1[W][OA

    Science.gov (United States)

    Li, Yuan-Yuan; Mao, Ke; Zhao, Cheng; Zhao, Xian-Yan; Zhang, Hua-Lei; Shu, Huai-Rui; Hao, Yu-Jin

    2012-01-01

    MdMYB1 is a crucial regulator of light-induced anthocyanin biosynthesis and fruit coloration in apple (Malus domestica). In this study, it was found that MdMYB1 protein accumulated in the light but degraded via a ubiquitin-dependent pathway in the dark. Subsequently, the MdCOP1-1 and MdCOP1-2 genes were isolated from apple fruit peel and were functionally characterized in the Arabidopsis (Arabidopsis thaliana) cop1-4 mutant. Yeast (Saccharomyces cerevisiae) two-hybrid, bimolecular fluorescence complementation, and coimmunoprecipitation assays showed that MdMYB1 interacts with the MdCOP1 proteins. Furthermore, in vitro and in vivo experiments indicated that MdCOP1s are necessary for the ubiquitination and degradation of MdMYB1 protein in the dark and are therefore involved in the light-controlled stability of the MdMYB1 protein. Finally, a viral vector-based transformation approach demonstrated that MdCOP1s negatively regulate the peel coloration of apple fruits by modulating the degradation of the MdMYB1 protein. Our findings provide new insight into the mechanism by which light controls anthocyanin accumulation and red fruit coloration in apple and even other plant species. PMID:22855936

  18. The Deadliest Catch: Reeling In Big Phish With a Deep MD5 Net

    Directory of Open Access Journals (Sweden)

    Brad Wardman

    2010-09-01

    Full Text Available Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} Because phishing continues to grow in prevalence resulting from new exploits and attack vectors, the traditional response using takedowns and blacklists does not seem to impede phishers.  A handful of law enforcement projects — such as the FBI's Digital PhishNet or the Internet Crime and Complaint Center (ic3.gov — have shown an ability to collect phishing data, but these collections have not resulted in a significant decline in criminal phishing activity.In this paper, a new system is demonstrated for prioritizing investigative resources. One way of correlating two phishing websites is by proving they were created by the same kit.  These kits contain the content files needed to create the counterfeit website as well as the email addresses and aliases of the web site creators.  This research provides a new method for correlating phishing evidence through the collection of phishing kits and a Deep MD5 Matching clustering algorithm. The correlation provides law enforcement with a means of prioritizing the allocation of limited investigative resources by identifying frequently repeating offenders.

  19. Artocarpus altilis proving its worth in toxic metal removal from the ...

    African Journals Online (AJOL)

    Artocarpus altilis proving its worth in toxic metal removal from the environment. PO Okolo, EEI Irabor, TP Abugu. Abstract. Nuts of breadfruit tree (Artocarpus altilis) obtained from Ugbowo Campus of University of Benin, Benin City, were dehusked and the husk thoroughly washed with distilled water, air-dried, pulverized and ...

  20. Using eternity variables to specify and prove a serializable database interface

    NARCIS (Netherlands)

    Hesselink, Wim H.

    Eternity variables are introduced to specify and verify serializability of transactions of a distributed database. Eternity variables are a new kind of auxiliary variables. They do not occur in the implementation but are used in specification and verification. Elsewhere it has been proved that

  1. The Secret Prover : Proving Possession of Arbitrary Files While not Giving Them Away

    NARCIS (Netherlands)

    Teepe, Wouter

    2005-01-01

    The Secret Prover is a Java application which allows a user (A) to prove to another user (B), that A possesses a file. If B also possesses this file B will get convinced, and if B does not possess this file B will gain no information on (the contents of) this file. This is the first implementation

  2. Mathematical Understanding and Proving Abilities: Experiment with Undergraduate Student by Using Modified Moore Learning Approach

    Science.gov (United States)

    Maya, Rippi; Sumarmo, Utari

    2011-01-01

    This paper reports findings of a post test experimental control group design conducted to investigate the role of modified Moore learning approach on improving students' mathematical understanding and proving abilities. Subjects of study were 56 undergraduate students of one state university in Bandung, who took advanced abstract algebra course.…

  3. Wind tunnel experiments to prove a hydraulic passive torque control concept for variable speed wind turbines

    NARCIS (Netherlands)

    Diepeveen, N.F.B.; Jarquin-Laguna, A.

    2014-01-01

    In this paper the results are presented of experiments to prove an innovative concept for passive torque control of variable speed wind turbines using fluid power technology. It is demonstrated that by correctly configuring the hydraulic drive train, the wind turbine rotor operates at or near

  4. The Jasmonate-Activated Transcription Factor MdMYC2 Regulates ETHYLENE RESPONSE FACTOR and Ethylene Biosynthetic Genes to Promote Ethylene Biosynthesis during Apple Fruit Ripening[OPEN

    Science.gov (United States)

    Xu, Yaxiu; Zhang, Lichao; Ji, Yinglin; Tan, Dongmei; Yuan, Hui

    2017-01-01

    The plant hormone ethylene is critical for ripening in climacteric fruits, including apple (Malus domestica). Jasmonate (JA) promotes ethylene biosynthesis in apple fruit, but the underlying molecular mechanism is unclear. Here, we found that JA-induced ethylene production in apple fruit is dependent on the expression of MdACS1, an ACC synthase gene involved in ethylene biosynthesis. The expression of MdMYC2, encoding a transcription factor involved in the JA signaling pathway, was enhanced by MeJA treatment in apple fruits, and MdMYC2 directly bound to the promoters of both MdACS1 and the ACC oxidase gene MdACO1 and enhanced their transcription. Furthermore, MdMYC2 bound to the promoter of MdERF3, encoding a transcription factor involved in the ethylene-signaling pathway, thereby activating MdACS1 transcription. We also found that MdMYC2 interacted with MdERF2, a suppressor of MdERF3 and MdACS1. This protein interaction prevented MdERF2 from interacting with MdERF3 and from binding to the MdACS1 promoter, leading to increased transcription of MdACS1. Collectively, these results indicate that JA promotes ethylene biosynthesis through the regulation of MdERFs and ethylene biosynthetic genes by MdMYC2. PMID:28550149

  5. The Jasmonate-Activated Transcription Factor MdMYC2 Regulates ETHYLENE RESPONSE FACTOR and Ethylene Biosynthetic Genes to Promote Ethylene Biosynthesis during Apple Fruit Ripening.

    Science.gov (United States)

    Li, Tong; Xu, Yaxiu; Zhang, Lichao; Ji, Yinglin; Tan, Dongmei; Yuan, Hui; Wang, Aide

    2017-06-01

    The plant hormone ethylene is critical for ripening in climacteric fruits, including apple (Malus domestica). Jasmonate (JA) promotes ethylene biosynthesis in apple fruit, but the underlying molecular mechanism is unclear. Here, we found that JA-induced ethylene production in apple fruit is dependent on the expression of MdACS1, an ACC synthase gene involved in ethylene biosynthesis. The expression of MdMYC2, encoding a transcription factor involved in the JA signaling pathway, was enhanced by MeJA treatment in apple fruits, and MdMYC2 directly bound to the promoters of both MdACS1 and the ACC oxidase gene MdACO1 and enhanced their transcription. Furthermore, MdMYC2 bound to the promoter of MdERF3, encoding a transcription factor involved in the ethylene-signaling pathway, thereby activating MdACS1 transcription. We also found that MdMYC2 interacted with MdERF2, a suppressor of MdERF3 and MdACS1 This protein interaction prevented MdERF2 from interacting with MdERF3 and from binding to the MdACS1 promoter, leading to increased transcription of MdACS1 Collectively, these results indicate that JA promotes ethylene biosynthesis through the regulation of MdERFs and ethylene biosynthetic genes by MdMYC2. © 2017 American Society of Plant Biologists. All rights reserved.

  6. Searching for fixed point combinators by using automated theorem proving: A preliminary report

    Energy Technology Data Exchange (ETDEWEB)

    Wos, L.; McCune, W.

    1988-09-01

    In this report, we establish that the use of an automated theorem- proving program to study deep questions from mathematics and logic is indeed an excellent move. Among such problems, we focus mainly on that concerning the construction of fixed point combinators---a problem considered by logicians to be significant and difficult to solve, and often computationally intensive and arduous. To be a fixed point combinator, THETA must satisfy the equation THETAx = x(THETAx) for all combinators x. The specific questions on which we focus most heavily ask, for each chosen set of combinators, whether a fixed point combinator can be constructed from the members of that set. For answering questions of this type, we present a new, sound, and efficient method, called the kernel method, which can be applied quite easily by hand and very easily by an automated theorem-proving program. For the application of the kernel method by a theorem-proving program, we illustrate the vital role that is played by both paramodulation and demodulation---two of the powerful features frequently offered by an automated theorem-proving program for treating equality as if it is ''understood.'' We also state a conjecture that, if proved, establishes the completeness of the kernel method. From what we can ascertain, this method---which relies on the introduced concepts of kernel and superkernel---offers the first systematic approach for searching for fixed point combinators. We successfully apply the new kernel method to various sets of combinators and, for the set consisting of the combinators B and W, construct an infinite set of fixed point combinators such that no two of the combinators are equal even in the presence of extensionality---a law that asserts that two combinators are equal if they behave the same. 18 refs.

  7. Pengaruh Brand Ambassador Terhadap Minat Beli Konsumen MD Clinic By Lazeta

    Directory of Open Access Journals (Sweden)

    Nurvita Septya Ningrum

    2016-10-01

    Full Text Available This research at MD Clinic by Lazeta which is in the beauty services that offer health care and facial, under of PT. Medina Global Care. MD Cilinic by Lazeta use the brand ambassador of introducing their products. The selection of brand ambassador motivated by positive image brought by the celebrities. Brand ambassadors chosen by the company as a symbol or a marker to represent the wishes and needs of prospective customers. MD Clinic by Lazeta choose Syahnaz as a brand ambassador for their products which is expected to to represent the product of MD Clinic by Lazeta, so the message can be understood by the consumer, who eventually would to lead the purchase intention. The purpose of this research was to investigate the influence of brand ambassadors on consumer purchase intention MD Clinic by Lazeta, Study on Business Administration Students year in 2103 Telkom University. Researchers used quantitative research methods. This research is population research, because all population is being respondent in this research. Populations of this research are 137 respondents. Collecting data in this research is conducted by using questionnaire distributed to all respondents, which all Students on Business Administration Telkom University who knows the MD Clinic by Lazeta. Data were analyzed using simple regression analysis and descriptive analysis.The results showed that the Brand Ambassador impact of consumer purchase intention on MD Clinic by Lazeta at the Students on Business Administration Telkom University years in 2013. Based on the calculation of the coefficient of determination (R2 can be seen the influence of brand ambassador variable (X on purchase intention (Y is 42.9%. While the remaining 57.1% is influenced by other factors which not examined in this research such as, pricing, marketing strategy and others.

  8. Electrical Subsurface Grounding Analysis

    Energy Technology Data Exchange (ETDEWEB)

    J.M. Calle

    2000-11-01

    The purpose and objective of this analysis is to determine the present grounding requirements of the Exploratory Studies Facility (ESF) subsurface electrical system and to verify that the actual grounding system and devices satisfy the requirements.

  9. Constructivist Grounded Theory?

    National Research Council Canada - National Science Library

    Barney G. Glaser, PhD, Hon. PhD

    2012-01-01

    AbstractI refer to and use as scholarly inspiration Charmaz’s excellent article on constructivist grounded theory as a tool of getting to the fundamental issues on why grounded theory is not constructivist...

  10. Constructivist Grounded Theory?

    OpenAIRE

    Glaser, Barney G.

    2007-01-01

    In meinem Beitrag greife ich zurück auf den ausgezeichneten und inspirierenden Artikel von CHARMAZ zu konstruktivistischer Grounded Theory, um an diesem Beispiel zu diskutieren, dass und warum die Grounded Theory kein konstruktivistisches Unterfangen ist. Ich versuche zu zeigen, dass "konstruktivistische Daten" bzw. konstruktivistische Anwendungen der Grounded Theory, sofern sie überhaupt existieren bzw. sinnvoll sein könnten, nur einen verschwindend kleinen Teil der Grounded Theory ausmachen...

  11. Constructivist Grounded Theory?

    Directory of Open Access Journals (Sweden)

    Barney G. Glaser, PhD, Hon. PhD

    2012-06-01

    Full Text Available AbstractI refer to and use as scholarly inspiration Charmaz’s excellent article on constructivist grounded theory as a tool of getting to the fundamental issues on why grounded theory is not constructivist. I show that constructivist data, if it exists at all, is a very, very small part of the data that grounded theory uses.

  12. Communication, concepts and grounding

    NARCIS (Netherlands)

    van der Velde, Frank; van der Velde, F.

    2015-01-01

    This article discusses the relation between communication and conceptual grounding. In the brain, neurons, circuits and brain areas are involved in the representation of a concept, grounding it in perception and action. In terms of grounding we can distinguish between communication within the brain

  13. Mathematical Understanding and Proving Abilities: Experiment With Undergraduate Student By Using Modified Moore Learning Approach

    Directory of Open Access Journals (Sweden)

    Rippi Maya

    2011-07-01

    Full Text Available This paper reports findings of  a  post test experimental control group design conducted to investigate the role of modified Moore learning approach  on improving students’ mathematical understanding and proving abilities. Subject of study were 56 undergradute students of one state university in Bandung, who took advanced abstract algebra course. Instrument of study were a set test of mathematical understanding ability, a set test of mathematical proving ability, and a set of students’ opinion scale on modified Moore learning approach. Data were analyzed by using two path ANOVA. The study found that proof construction process was more difficult than mathematical understanding  task  for all students, and students still posed some difficulties on constructing mathematical proof task.  The study also found there were not differences  between students’  abilities on mathematical understanding and on proving abilities of  the both classes, and both abilities were classified as mediocre. However, in modified Moore learning approach class there were more students who got above average grades on mathematical understanding than those of conventional class. Moreover, students performed positive  opinion toward  modified Moore learning approach. They  were  active in questioning and solving problems, and in explaining their works in front of class as well, while students of conventional teaching prefered to listen to lecturer’s explanation. The study also found that there was no interaction between learning approach and students’ prior mathematics ability on mathematical understanding and proving abilities,  but  there were  quite strong  association between students’ mathematical understanding and proving abilities.Keywords:  modified Moore learning approach, mathematical understanding ability, mathematical proving ability. DOI: http://dx.doi.org/10.22342/jme.2.2.751.231-250

  14. The molecular mechanism underlying anthocyanin metabolism in apple using the MdMYB16 and MdbHLH33 genes.

    Science.gov (United States)

    Xu, Haifeng; Wang, Nan; Liu, Jingxuan; Qu, Changzhi; Wang, Yicheng; Jiang, Shenghui; Lu, Ninglin; Wang, Deyun; Zhang, Zongying; Chen, Xuesen

    2017-05-01

    MdMYB16 forms homodimers and directly inhibits anthocyanin synthesis via its C-terminal EAR repressor. It weakened the inhibitory effect of MdMYB16 on anthocyanin synthesis when overexpressing MdbHLH33 in callus overexpressing MdMYB16. MdMYB16 could interact with MdbHLH33. Anthocyanins are strong antioxidants that play a key role in the prevention of cardiovascular disease, cancer, and diabetes. The germplasm of Malus sieversii f. neidzwetzkyana is important for the study of anthocyanin metabolism. To date, only limited studies have examined the negative regulatory mechanisms underlying anthocyanin synthesis in apple. Here, we analyzed the relationship between anthocyanin levels and MdMYB16 expression in mature Red Crisp 1-5 apple (M. domestica) fruit, generated an evolutionary tree, and identified an EAR suppression sequence and a bHLH binding motif of the MdMYB16 protein using protein sequence analyses. Overexpression of MdMYB16 or MdMYB16 without bHLH binding sequence (LBSMdMYB16) in red-fleshed callus inhibited MdUFGT and MdANS expression and anthocyanin synthesis. However, overexpression of MdMYB16 without the EAR sequence (LESMdMYB16) in red-fleshed callus had no inhibitory effect on anthocyanin. The yeast one-hybrid assay showed that MdMYB16 and LESMdMYB16 interacted the promoters of MdANS and MdUFGT, respectively. Yeast two-hybrid, pull-down, and bimolecular fluorescence complementation assays showed that MdMYB16 formed homodimers and interacted with MdbHLH33, however, the LBSMdMYB16 could not interact with MdbHLH33. We overexpressed MdbHLH33 in callus overexpressing MdMYB16 and found that it weakened the inhibitory effect of MdMYB16 on anthocyanin synthesis. Together, these results suggested that MdMYB16 and MdbHLH33 may be important part of the regulatory network controlling the anthocyanin biosynthetic pathway.

  15. Chosen-Prefix Collisions for MD5 and Colliding X.509 Certificates for Different Identities

    Science.gov (United States)

    Stevens, Marc; Lenstra, Arjen; de Weger, Benne

    We present a novel, automated way to find differential paths for MD5. As an application we have shown how, at an approximate expected cost of 250 calls to the MD5 compression function, for any two chosen message prefixes P and P', suffixes S and S' can be constructed such that the concatenated values P||S and P'||S' collide under MD5. Although the practical attack potential of this construction of chosen-prefix collisions is limited, it is of greater concern than random collisions for MD5. To illustrate the practicality of our method, we constructed two MD5 based X.509 certificates with identical signatures but different public keys and different Distinguished Name fields, whereas our previous construction of colliding X.509 certificates required identical name fields. We speculate on other possibilities for abusing chosen-prefix collisions. More details than can be included here can be found on www.win.tue.nl/hashclash/ChosenPrefixCollisions/.

  16. The MD-MEd Joint-Degree Program at Vanderbilt University: Training Future Expert Medical Educators.

    Science.gov (United States)

    Sullivan, William M; DeVolder, Jacob; Bhutiani, Monica; Neal, Kristen W; Miller, Bonnie M

    2017-08-01

    Some medical students are drawn to medical education as an area of academic specialization. However, few options exist for medical students who wish to build a scholarly foundation for future careers in medical education. In 2011, Vanderbilt University School of Medicine (VUSM) and Peabody College of Education and Human Development at Vanderbilt University partnered to establish a novel dual-degree program that, through transfer of credit, allows students to graduate with both an MD and a master of education (MEd) degree in five years. The MD-MEd joint-degree program equips students with robust knowledge and skills related to general education while providing opportunities through independent studies and capstone projects to contextualize these ideas in medical education. This innovation at Vanderbilt University demonstrates the feasibility of an MD-MEd joint-degree program. MD-MEd graduates' demonstrated commitment to medical education and credentials will allow them to take on greater educational responsibilities earlier in their careers and quickly gain experience. The three author participants feel their experiences allowed them to achieve desired competencies as educators. They have each gained early experience by chairing the Student Curriculum Committee and contributing to major curricular reform at VUSM. The authors plan to integrate specific medical education competencies into the program, which will require MD-MEd students to develop and demonstrate proficiency in the knowledge and skills expected of dedicated medical educators. Graduates' career trajectories will be tracked to explore whether they become medical educators, conduct educational research, and assume leadership positions.

  17. Desain Aplikasi Algoritma MD5 (Message Digest 5 Pada Media SMS Berbasis Android Mobile

    Directory of Open Access Journals (Sweden)

    Zaiful Bahri

    2017-11-01

    Full Text Available AbstrakTulisan ini membahas tentang disain Aplikasi Algoritma MD5. Dalam desain ini dibuat model kirim dan terima SMS aman. Dari model ini bisa dibuat desain aplikasi berbasis objek menggunakan Unified Modeling Language (UML, State Machine untuk menggambarkan status pengiriman pesan dan Graphical User Interface (GUI yang user friendly menggunakan Android Studio 2.3.3 dan  gradle 3.3. Desain ini juga memerlukan sebuah database. Hasil desain ini dapat digunakan untuk membangun aplikasi mengirim dan menerima pesan aman secara umum dan khususnya aplikasi algoritma MD5 menggunakan Android. Kata kunci : Aplikasi, algoritma MD5, Android, SMS aman AbstractThis paper discusses the design of MD5 Algorithm application. In design is created a model to send and receive secured SMS. From this model is made an application design which is based on object using Unified Modeling Language (UML, State machine to give describing state of send and recive massage and Graphical User Interface (GUI which is user friendly using Android Studio 2.3.3 and Gradle 3.3. The application design also uses a database. The result of  design can be used to create an application to send and receive a secure message in general and especially message digest 5 algorithm using Android.  Keywords : Application, MD5 algorithm, Android, secure SMS

  18. Opinion of stakeholders on existing curriculum for postgraduate (MD) course in Pharmacology: A survey

    Science.gov (United States)

    Badyal, Dinesh K.; Daniel, Sujit R.

    2016-01-01

    Objectives: To survey the opinion about various curricular components of Doctor of Medicine (MD) pharmacology curriculum in India by stakeholders, including faculty and students. Materials and Methods: An online survey was done to evaluate the various curricular components of MD pharmacology curriculum being used in India. A total of 393 respondents including faculty, MD students, and other stakeholders completed the survey. The survey was developed using SurveyMonkey platform and link to survey was E-mailed to stakeholders. The results were expressed as percentages. Results: There was a balanced representation of respondents from various designations, teaching experience, regions, and age groups. Most of the respondents (83%) were aware of the MD pharmacology curriculum. However, they reported that it is more inclined to knowledge domain. About half of respondents (53%) said that animal experiments are being used. The most common teaching methods mentioned are seminars (98.5%), journal clubs (95%), and practical exercises by postgraduates (73%), but there is less use of newer methods (25%) in theory and less of clinical pharmacology exercise (39%) in practical classes. The log books are maintained but not assessed regularly. Internal assessment is sparingly used. Conclusion: The MD pharmacology curriculum needs to be made uniform at the national level and updated to include the newer methods in teaching-learning and assessment. There should be sharing of newer methods at a common platform implemented at the national level. PMID:28031602

  19. Mendel,MD: A user-friendly open-source web tool for analyzing WES and WGS in the diagnosis of patients with Mendelian disorders.

    Science.gov (United States)

    G C C L Cardenas, Raony; D Linhares, Natália; L Ferreira, Raquel; Pena, Sérgio D J

    2017-06-01

    Whole exome and whole genome sequencing have both become widely adopted methods for investigating and diagnosing human Mendelian disorders. As pangenomic agnostic tests, they are capable of more accurate and agile diagnosis compared to traditional sequencing methods. This article describes new software called Mendel,MD, which combines multiple types of filter options and makes use of regularly updated databases to facilitate exome and genome annotation, the filtering process and the selection of candidate genes and variants for experimental validation and possible diagnosis. This tool offers a user-friendly interface, and leads clinicians through simple steps by limiting the number of candidates to achieve a final diagnosis of a medical genetics case. A useful innovation is the "1-click" method, which enables listing all the relevant variants in genes present at OMIM for perusal by clinicians. Mendel,MD was experimentally validated using clinical cases from the literature and was tested by students at the Universidade Federal de Minas Gerais, at GENE-Núcleo de Genética Médica in Brazil and at the Children's University Hospital in Dublin, Ireland. We show in this article how it can simplify and increase the speed of identifying the culprit mutation in each of the clinical cases that were received for further investigation. Mendel,MD proved to be a reliable web-based tool, being open-source and time efficient for identifying the culprit mutation in different clinical cases of patients with Mendelian Disorders. It is also freely accessible for academic users on the following URL: https://mendelmd.org.

  20. Mendel,MD: A user-friendly open-source web tool for analyzing WES and WGS in the diagnosis of patients with Mendelian disorders.

    Directory of Open Access Journals (Sweden)

    Raony G C C L Cardenas

    2017-06-01

    Full Text Available Whole exome and whole genome sequencing have both become widely adopted methods for investigating and diagnosing human Mendelian disorders. As pangenomic agnostic tests, they are capable of more accurate and agile diagnosis compared to traditional sequencing methods. This article describes new software called Mendel,MD, which combines multiple types of filter options and makes use of regularly updated databases to facilitate exome and genome annotation, the filtering process and the selection of candidate genes and variants for experimental validation and possible diagnosis. This tool offers a user-friendly interface, and leads clinicians through simple steps by limiting the number of candidates to achieve a final diagnosis of a medical genetics case. A useful innovation is the "1-click" method, which enables listing all the relevant variants in genes present at OMIM for perusal by clinicians. Mendel,MD was experimentally validated using clinical cases from the literature and was tested by students at the Universidade Federal de Minas Gerais, at GENE-Núcleo de Genética Médica in Brazil and at the Children's University Hospital in Dublin, Ireland. We show in this article how it can simplify and increase the speed of identifying the culprit mutation in each of the clinical cases that were received for further investigation. Mendel,MD proved to be a reliable web-based tool, being open-source and time efficient for identifying the culprit mutation in different clinical cases of patients with Mendelian Disorders. It is also freely accessible for academic users on the following URL: https://mendelmd.org.

  1. Evaluation of hydroacid complex in the forward osmosis–membrane distillation (FO–MD) system for desalination

    KAUST Repository

    Wang, Peng

    2015-11-01

    The incorporation of membrane distillation (MD) into forward osmosis (FO) provides process sustainability to regenerate the draw solution and to produce clean water simultaneously. However, the reverse salt flux is the major hurdle in the FO-MD system because it not only reduces the effective osmotic driving force across the membrane but also increases the replenishment cost and scaling issue. For the first time, a hydroacid complex with abundant hydrophilic groups and ionic species is evaluated as the draw solutes in the hybrid FO-MD system consisting of multi-bore PVDF MD membranes for seawater/brackish desalination. In order to evaluate the practicality of the hydroacid complex in the FO-MD system, FO and MD experiments were conducted at elevated temperatures and concentrations. The hydroacid complex has displayed desired properties such as high solubility, low viscosity, excellent thermal stability and minimal reverse salt flux suitable for FO and MD operations. FO-MD desalination process was demonstrated with a highest seawater desalination flux of 6/32 LMH (FO/MD). This study may open up the prospective of employing the hydroacid complex as the draw solute in FO-MD hybrid systems for seawater /brackish desalination. © 2015 Elsevier B.V.

  2. Proving and Improving Wave Models in the Arctic Ocean and its MIZ

    Science.gov (United States)

    2015-09-30

    scale, the Greenland Sea Odden which is important for deep convection. The increased open water area present in the autumn Arctic Ocean , particularly...263(5144), 218–221, doi:10.1126/science.263.5144.218. Hunkins, K. (1966), Ekman drift currents in the Arctic Ocean , Deep Sea Res., 13(4), 607–620...1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. Proving and Improving Wave Models in the Arctic Ocean

  3. Rigour and grounded theory.

    Science.gov (United States)

    Cooney, Adeline

    2011-01-01

    This paper explores ways to enhance and demonstrate rigour in a grounded theory study. Grounded theory is sometimes criticised for a lack of rigour. Beck (1993) identified credibility, auditability and fittingness as the main standards of rigour for qualitative research methods. These criteria were evaluated for applicability to a Straussian grounded theory study and expanded or refocused where necessary. The author uses a Straussian grounded theory study (Cooney, In press) to examine how the revised criteria can be applied when conducting a grounded theory study. Strauss and Corbin (1998b) criteria for judging the adequacy of a grounded theory were examined in the context of the wider literature examining rigour in qualitative research studies in general and grounded theory studies in particular. A literature search for 'rigour' and 'grounded theory' was carried out to support this analysis. Criteria are suggested for enhancing and demonstrating the rigour of a Straussian grounded theory study. These include: cross-checking emerging concepts against participants' meanings, asking experts if the theory 'fit' their experiences, and recording detailed memos outlining all analytical and sampling decisions. IMPLICATIONS FOR RESEARCH PRACTICE: The criteria identified have been expressed as questions to enable novice researchers to audit the extent to which they are demonstrating rigour when writing up their studies. However, it should not be forgotten that rigour is built into the grounded theory method through the inductive-deductive cycle of theory generation. Care in applying the grounded theory methodology correctly is the single most important factor in ensuring rigour.

  4. Rice husk ash with high carbon content proves favourable for soil stabilization

    NARCIS (Netherlands)

    Pham, P.V.; van der Star, WRL; van Paassen, L.A.; Ye, G.

    2015-01-01

    Rice husk ash is a promising pozzolanic material produced from rice husk burning and has significant potential a sustainable replacement for cement in construction and ground improvement applications. In this study the effect of burning conditions on the ash reactivity and its potential for soil

  5. Divide and conquer method for proving gaps of frustration free Hamiltonians

    DEFF Research Database (Denmark)

    Kastoryano, Michael J.; Lucia, Angelo

    2017-01-01

    Providing system-size independent lower bounds on the spectral gap of local Hamiltonian is in general a hard problem. For the case of finite-range, frustration free Hamiltonians on a spin lattice of arbitrary dimension, we show that a property of the ground state space is sufficient to obtain suc...

  6. Agent Reasoning Transparency: The Influence of Information Level on Automation-Induced Complacency

    Science.gov (United States)

    2017-06-30

    Qu Z. RoboLeader: a surrogate for enhancing the human control of a team of robots. Aberdeen Proving Ground (MD): Army Research Laboratory (US); 2010...Situation awareness- based agent transparency. Aberdeen Proving Ground (MD): Army Research Approved for public release; distribution is unlimited...Proving Ground (MD): Army Research Laboratory (US); 2015 Sep. Report No.: ARL- TR-7466. Monsell S. Task switching. Trends Cog Sci. 2003;7(3):134–140

  7. Agent Reasoning Transparency: The Influence of Information Level on Automation Induced Complacency

    Science.gov (United States)

    2017-06-01

    human control of a team of robots. Aberdeen Proving Ground (MD): Army Research Laboratory (US); 2010 Feb. Report No.: ARL-MR-0735. http://www.dtic.mil...Proving Ground (MD): Army Research Approved for public release; distribution is unlimited. 121 Laboratory (US); 2014 Apr. Report No.: ARL-TR...agent transparency on multi-robot management effectiveness. Aberdeen Proving Ground (MD): Army Research Laboratory (US); 2015 Sep. Report No.: ARL

  8. MD/MBA programs in the United States: evidence of a change in health care leadership.

    Science.gov (United States)

    Larson, David B; Chandler, Maria; Forman, Howard P

    2003-03-01

    Managerial sciences are playing an increasingly prominent role in the organization and delivery of health care. Despite popular media reports that a rising number of physicians are acquiring a background in this discipline through MD/MBA (medical and master of business administration) programs, no recent study has verified this. This study measured changes in the number and nature of the affiliations between management and medicine in the form of MD/MBA programs in the United States. Surveys of admission officers of 125 U.S. allopathic medical schools and of the overseers of each joint MD/MBA degree program were administered in May-October 2001. Main outcome measures included program growth, curriculum and degree requirements, application and admission requirements, and program leadership and organization. The number of MD/MBA programs grew from six to 33 between 1993 and 2001, and 17 more medical schools were considering establishing the joint-degree program. Ten, 15, and 20 programs produced 27, 42, and 61 graduates in 1999, 2000, and 2001, respectively, and over 100 students were expected to graduate per year when all 33 programs matured. Program structures and oversight indicate a spectrum of philosophies regarding the appropriate level of integration of the two degrees. MD/MBA programs apparently attempt to complement medical education with management education rather than the converse. The growth in the numbers of MD/MBA programs and participants indicates rising cooperation between medical and business schools and increasing interest in management education early in the careers of graduating physicians.

  9. The AINTEGUMENTA genes, MdANT1 and MdANT2, are associated with the regulation of cell production during fruit growth in apple (Malus × domestica Borkh.).

    Science.gov (United States)

    Dash, Madhumita; Malladi, Anish

    2012-06-25

    Fruit growth in apple (Malus × domestica Borkh.) is mediated by cell production and expansion. Genes involved in regulating these processes and thereby fruit growth, are not well characterized. We hypothesized that the apple homolog(s) of AINTEGUMENTA (ANT), an APETALA2-repeat containing transcription factor, regulates cell production during fruit growth in apple. Two ANT genes, MdANT1 and MdANT2, were isolated from apple and their expression was studied during multiple stages of fruit development. MdANT1 and MdANT2 expression was high during early fruit growth coincident with the period of cell production, rapidly declined during exit from cell production, and remained low during the rest of fruit development. The effects of increase in carbohydrate availability during fruit growth were characterized. Increase in carbohydrate availability enhanced fruit growth largely through an increase in cell production. Expression of MdANT1 and MdANT2 increased sharply by up to around 5-fold in response to an increase in carbohydrate availability. Expression of the ANT genes was compared across two apple genotypes, 'Gala' and 'Golden Delicious Smoothee' (GS), which differ in the extent of fruit growth, largely due to differences in cell production. In comparison to 'Gala', the larger fruit-size genotype, GS, displayed higher levels and a longer duration of MdANT1 and MdANT2 expression. Expression of the ANTs and cell cycle genes in the fruit core and cortex tissues isolated using laser capture microdissection was studied. During early fruit growth, expression of the MdANTs was higher within the cortex, the tissue that constitutes the majority of the fruit. Additionally, MdANT1 and MdANT2 expression was positively correlated with that of A- and B-type CYCLINS, B-type CYCLIN-DEPENDENT-KINASES (CDKBs) and MdDEL1. Multiple lines of evidence from this study suggest that MdANT1 and MdANT2 regulate cell production during fruit growth in apple. ANTs may coordinate the expression of

  10. LHC Transvers Profile Monitors studies (MD on May 6th, 2011)

    CERN Document Server

    Bravin, E; Dehning, B; Emery, J; Lefevre, T; Gras, JJ; Jeff, A; Rabiller, A; Roncarolo, F; Sapinski, M; Kain, V; Pojer, M; Bartosik, H; Salvant, B

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 6-May-2011 (from 2 to 10 a.m.), dedicated to study Wire Scanners (WS), Synchrotron Radiation Monitors (BSRT) and Beam Gas Ionization Monitors (BGI). The MD aimed at performing different studies on the individual monitors as well as at cross calibrating them with beams composed of bunches with different transverse emittances in stable conditions. At the same time, it was possible to perform calibration studies with the Abort Gap Monitor (AGM) and Longitudinal Density Monitor (LDM) that share the extracted light with the BSRT.

  11. Computation of shear viscosity of colloidal suspensions by SRD-MD

    Energy Technology Data Exchange (ETDEWEB)

    Laganapan, A. M. K.; Videcoq, A., E-mail: arnaud.videcoq@unilim.fr; Bienia, M. [SPCTS, UMR 7315, ENSCI, CNRS, Centre Européen de la Céramique, 12 rue Atlantis, 87068 Limoges Cedex (France); Ala-Nissila, T. [COMP CoE at the Department of Applied Physics, Aalto University School of Science, P.O. Box 11000, FIN-00076 Aalto, Espoo (Finland); Department of Physics, Brown University, Providence, Rhode Island 02912-1843 (United States); Bochicchio, D.; Ferrando, R. [Dipartimento di Fisica and CNR-IMEM, via Dodecaneso 33, Genova I-16146 (Italy)

    2015-04-14

    The behaviour of sheared colloidal suspensions with full hydrodynamic interactions (HIs) is numerically studied. To this end, we use the hybrid stochastic rotation dynamics-molecular dynamics (SRD-MD) method. The shear viscosity of colloidal suspensions is computed for different volume fractions, both for dilute and concentrated cases. We verify that HIs help in the collisions and the streaming of colloidal particles, thereby increasing the overall shear viscosity of the suspension. Our results show a good agreement with known experimental, theoretical, and numerical studies. This work demonstrates the ability of SRD-MD to successfully simulate transport coefficients that require correct modelling of HIs.

  12. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools

    OpenAIRE

    Amy Franciscovich; Dhananjay Vaidya; Joe Doyle; Josh Bolinger; Montserrat Capdevila; Marcus Rice; Leslie Hancock; Tanya Mahr; Mogul, Douglas B.

    2015-01-01

    Biliary atresia (BA) is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone's camera and color recognition software to analyze an infant's stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 an...

  13. Computation of shear viscosity of colloidal suspensions by SRD-MD

    Science.gov (United States)

    Laganapan, A. M. K.; Videcoq, A.; Bienia, M.; Ala-Nissila, T.; Bochicchio, D.; Ferrando, R.

    2015-04-01

    The behaviour of sheared colloidal suspensions with full hydrodynamic interactions (HIs) is numerically studied. To this end, we use the hybrid stochastic rotation dynamics-molecular dynamics (SRD-MD) method. The shear viscosity of colloidal suspensions is computed for different volume fractions, both for dilute and concentrated cases. We verify that HIs help in the collisions and the streaming of colloidal particles, thereby increasing the overall shear viscosity of the suspension. Our results show a good agreement with known experimental, theoretical, and numerical studies. This work demonstrates the ability of SRD-MD to successfully simulate transport coefficients that require correct modelling of HIs.

  14. On asymptotic stability in energy space of ground states of NLS in 2D

    OpenAIRE

    Cuccagna, Scipio; Tarulli, Mirko

    2009-01-01

    We transpose work by K.Yajima and by T.Mizumachi to prove dispersive and smoothing estimates for dispersive solutions of the linearization at a ground state of a Nonlinear Schr\\"odinger equation (NLS) in 2D. As an application we extend to dimension 2D a result on asymptotic stability of ground states of NLS proved in the literature for all dimensions different from 2.

  15. On asymptotic stability in energy space of ground states of NLS in 2D

    Science.gov (United States)

    Cuccagna, Scipio; Tarulli, Mirko

    2009-07-01

    We transpose work by K.Yajima and by T.Mizumachi to prove dispersive and smoothing estimates for dispersive solutions of the linearization at a ground state of a Nonlinear Schr\\"odinger equation (NLS) in 2D. As an application we extend to dimension 2D a result on asymptotic stability of ground states of NLS proved in the literature for all dimensions different from 2.

  16. Serum soluble MD-1 levels increase with disease progression in autoimmune prone MRL(lpr/lpr) mice.

    Science.gov (United States)

    Sasaki, Sumiyo; Nagai, Yoshinori; Yanagibashi, Tsutomu; Watanabe, Yasuharu; Ikutani, Masashi; Kariyone, Ai; Tsuneyama, Koichi; Hirai, Yoshikatsu; Takatsu, Kiyoshi

    2012-01-01

    MD-1 is a secreted protein that forms a complex with radioprotective 105 (RP105) and this complex plays a crucial role in lipopolysaccharide (LPS) recognition by B cells. Disease progression is known to improve in RP105-deficient lupus-prone MRL(lpr/lpr) mice. Furthermore, a soluble form of the homologous MD-2 protein is present in the plasma of septic patients and can opsonize gram-negative bacteria in cooperation with Toll-like receptor (TLR) 4. We have now established a flow cytometry-based assay to detect the soluble form of murine MD-1 (sMD-1) and explored potential roles in autoimmunity. The assay was quantitative and validated with sera from MD-1-deficient mice. Interestingly, heat-inactivated murine serum diminished the ability of sMD-1 to bind RP105. The sMD-1 was secreted by bone marrow-derived macrophages from C57BL/6 mice. Autoimmune prone MRL(lpr/lpr) mice had higher levels of sMD-1 than control MRL(+/+) mice, and levels markedly increased with disease progression. Expression of MD-1 but not MD-2 mRNA increased with age in the liver and kidney of MRL(lpr/lpr) mice. Finally, immunohistochemical analyses revealed that MD-1 was present in infiltrated macrophages within perivascular lesions of the MRL(lpr/lpr) kidney. This correlation suggests that sMD-1 may contribute to pathogenesis in this autoimmune disease model. Copyright © 2011 Elsevier Ltd. All rights reserved.

  17. How cytogenetical methods help victims prove radiation exposure and claim right for social support: NCERM experience

    Energy Technology Data Exchange (ETDEWEB)

    Aleksanin, S., E-mail: Aleksanin@arcerm.spb.ru [Nikiforov Russian Center of Emergency and Radiation Medicine EMERCOM of Russia, (NRCERM) ul. Akademika Lebedeva 4/2, 194044 St. Petersburg (Russian Federation); Slozina, N., E-mail: NataliaSlozina@peterlink.ru [Nikiforov Russian Center of Emergency and Radiation Medicine EMERCOM of Russia, (NRCERM) ul. Akademika Lebedeva 4/2, 194044 St. Petersburg (Russian Federation); Neronova, E.; Smoliakov, E. [Nikiforov Russian Center of Emergency and Radiation Medicine EMERCOM of Russia, (NRCERM) ul. Akademika Lebedeva 4/2, 194044 St. Petersburg (Russian Federation)

    2011-09-15

    Russian citizens who were irradiated because of radiation disasters, nuclear weapons testing and some other sources have a right to some social support and financial compensation. In order to get this compensation people have to prove that they were irradiated. As it is, not all victims for a variety of reasons have formal documents. Thus they apply for cytogenetic investigation to prove irradiation months, years and even decades after irradiation. Since 1992 the cytogenetic investigations related to radiation exposure were performed in NRCERM for more than 700 people. At the beginning of this investigation FISH method was not certified as a biodosimenty test in Russia. Only dicentric analysis was approved as a proof of irradiation. It is known that the rate of dicentrics decrease in time, but the residual level of cytogenetical markers could be revealed a long time after a radiation accident. Thus the dicentric analysis was performed for the people who applied for biological indication of radiation exposure at that time. Rates of dicentrics exceeding control levels were revealed in half the people who applied for radiation conformation. Now FISH method is certified in Russia and both cytogenetic tests of biodosimetry (dicentrics and FISH) are available for all comers. Increased levels of translocations were found in 8 cases (the dose rate from 0.16 to 0.64 Gy). On the basis of the results of cytogenetic tests official documents were supplied to these people and they were entitled to apply for radiation exposure compensation. Thus cytogenetic tests are very effective and in some cases the only possible way for the victims to prove irradiation exposure and to apply for radiation exposure compensation a long time after an accident.

  18. Proving Unlawful Discrimination in Capital Cases: In Quest of an Adequate Standard of Proof

    Directory of Open Access Journals (Sweden)

    Gregor Maučec

    2017-08-01

    Full Text Available In spite of some early judicial, political and scholarly discussions, as well as more recent scientific explorations of the topic, problems and concerns with proving discrimination in individual capital cases continue to be among the most debatable issues in human rights and criminal justice. In general, domestic courts (in particular US courts seem to remain relatively perfunctory and hostile to individual discrimination challenges in capital trials. They normally require capital defendants alleging discrimination to prove something which is virtually impossible to prove. On the other hand, numerous capital defence attorneys, legal commentators and even some of the trial judges themselves lay strictures on the existing judicial approach which almost routinely rejects discrimination claims in capital cases. They contend that appropriate modifications in current legislative arrangements and mechanical adjudication policy and practice are urgent and indispensable for more equitable resolutions and for a truly even-handed criminal justice system. In particular, there are concerns regarding the adequate distribution of the burden of proof between the litigants. Moreover, no clear or uniform approach to this conundrum can be identified in the international jurisprudence. This article seeks to provide some definite answers to open and conceptual questions posed in an attempt to legally define ‘the minimum core content’ of the evidentiary standard – as implicitly contained in the relevant international human rights treaties’ provisions – to be applied in capital sentencing discrimination cases. Additionally, part of this same standard of proof can also qualify as a general principle of international law, particularly in relation to impartial, unbiased and non-discriminatory approaches and decision-making by the judges and jurors involved in complex capital cases.

  19. [Introduction to grounded theory].

    Science.gov (United States)

    Wang, Shou-Yu; Windsor, Carol; Yates, Patsy

    2012-02-01

    Grounded theory, first developed by Glaser and Strauss in the 1960s, was introduced into nursing education as a distinct research methodology in the 1970s. The theory is grounded in a critique of the dominant contemporary approach to social inquiry, which imposed "enduring" theoretical propositions onto study data. Rather than starting from a set theoretical framework, grounded theory relies on researchers distinguishing meaningful constructs from generated data and then identifying an appropriate theory. Grounded theory is thus particularly useful in investigating complex issues and behaviours not previously addressed and concepts and relationships in particular populations or places that are still undeveloped or weakly connected. Grounded theory data analysis processes include open, axial and selective coding levels. The purpose of this article was to explore the grounded theory research process and provide an initial understanding of this methodology.

  20. Airport Ground Staff Scheduling

    DEFF Research Database (Denmark)

    Clausen, Tommy

    travels safely and efficiently through the airport. When an aircraft lands, a significant number of tasks must be performed by different groups of ground crew, such as fueling, baggage handling and cleaning. These tasks must be complete before the aircraft is able to depart, as well as check......-in and security services. These tasks are collectively known as ground handling, and are the major source of activity with airports. The business environments of modern airports are becoming increasingly competitive, as both airports themselves and their ground handling operations are changing to private...... ownership. As airports are in competition to attract airline routes, efficient and reliable ground handling operations are imperative for the viability and continued growth of both airports and airlines. The increasing liberalization of the ground handling market prompts ground handling operators...

  1. A Simple Application of Lightweight Fusion to Proving the Equivalence of Abstract Machines

    DEFF Research Database (Denmark)

    Danvy, Olivier; Millikin, Kevin

    2007-01-01

    We show how Ohori and Sasano's recent lightweight fusion by fixed-point promotion provides a simple way to prove the equivalence of the two standard styles of specification of abstract machines: (1) as a transition function together with a `driver loop' implementing the iteration of this transition...... function; and (2) as a function directly iterating upon a configuration until reaching a final state, if ever. The equivalence hinges on the fact that the latter style of specification is a fused version of the former one. The need for such a simple proof is motivated by our recent work on syntactic...... correspondences between reduction semantics and abstract machines, using refocusing...

  2. Respirometry applied to kinetic characterization of activated sludge; Caratterizzazione cinetica di fanghi attivi mediante prove respirometriche

    Energy Technology Data Exchange (ETDEWEB)

    Ricco, G. [Consiglio Nazionale delle Ricerche, Bari (Italy). Istituto Nazionale di Ricerca sulle Acque; Tomei, M.C. [Consiglio Nazionale delle Ricerche, Rome (Italy). Istituto Nazionale di Ricerca sulle Acque

    1999-10-01

    In this paper an experimental procedure to evaluate the biomass characterization parameters by utilizing respirometric tests is presented. Beside, a procedure for data analysis based on the kinetic, stoichiometric and mass balance equations describing the system in the various operating conditions required for the evaluation of the different parameters is proposed. Finally, the results of a first example of application to the sludge characterization of a civil waste water treatment plant are reported. [Italian] Viene presentato un primo esempio applicativo relativo alla caratterizzazione di un fango attivo proveniente da un impianto di trattamento di reflui civili utilizzando il modello cinetico di Monod con l'impiego di prove respirometriche.

  3. Proving the correctness of unfold/fold program transformations using bisimulation

    DEFF Research Database (Denmark)

    Hamilton, Geoff W.; Jones, Neil

    2011-01-01

    proofs show the original and transformed programs are contextually equivalent, i.e., have the same termination behaviour in all closed contexts. Contextual equivalence can, however, be difficult to establish directly. Gordon and Howe use an alternative approach: to represent a program's behaviour...... to describe contextually, due to use of non-local information. We show that weak bisimulation on labelled transition systems gives an elegant framework to prove contextual equivalence of original and transformed programs. One reason is that folds can be seen in the context of corresponding unfolds....

  4. How to prove the validity of a complex ballot encryption to the voter and the public

    OpenAIRE

    Joaquim, Rui

    2014-01-01

    One crucial aspect of any verifiable electronic voting system that uses encryption is the proof that the vote encryption is well-formed, i.e. the proof that the vote encryption encrypts a valid vote accordingly to the race specification. It makes no sense accepting an encrypted vote if, at the end of the election, the vote cannot be included in the tally because it is badly formed. Proving the validity of a complex vote encryption, without revealing the vote, is a hard problem. This paper...

  5. Seismic proving test of ultimate piping strength (current status of preliminary tests)

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, K.; Namita, Y.; Abe, H.; Ichihashi, I. [Seismic Engineering Center, NUPEC, Tokyo (Japan); Suzuki, K. [Tokyo Metropolitan Universtity, Hachioji (Japan); Ishiwata, M. [Hitachi, Ltd., Hitachi (Japan); Fujiwaka, T. [Ishikawajima-Harima Heavy Industries Co., Ltd., Yokohama (Japan); Yokota, H. [Mitsubishi Heavy Industries Ltd., Kobe (Japan)

    2001-07-01

    In 1998 Fiscal Year, the 6 year program of piping tests was initiated with the following objectives: i) to clarify the elasto-plastic response and ultimate strength of nuclear piping, ii) to ascertain the seismic safety margin of the current seismic design code for piping, and iii) to assess new allowable stress rules. In order to resolve extensive technical issues before proceeding on to the seismic proving test of a large-scale piping system, a series of preliminary tests of materials, piping components and simplified piping systems is intended. In this paper, the current status of the material tests and the piping component tests is reported. (author)

  6. Fragment Molecular Orbital method-based Molecular Dynamics (FMO-MD) as a simulator for chemical reactions in explicit solvation.

    Science.gov (United States)

    Komeiji, Yuto; Ishikawa, Takeshi; Mochizuki, Yuji; Yamataka, Hiroshi; Nakano, Tatsuya

    2009-01-15

    Fragment Molecular Orbital based-Molecular Dynamics (FMO-MD, Komeiji et al., Chem Phys Lett 2003, 372, 342) is an ab initio MD method suitable for large molecular systems. Here, FMO-MD was implemented to conduct full quantum simulations of chemical reactions in explicit solvation. Several FMO-MD simulations were performed for a sphere of water to find a suitable simulation protocol. It was found that annealing of the initial configuration by a classical MD brought the subsequent FMO-MD trajectory to faster stabilization, and also that use of bond constraint in the FMO-MD heating stage effectively reduced the computation time. Then, the blue moon ensemble method (Sprik and Ciccotti, J Chem Phys 1998, 109, 7737) was implemented and was tested by calculating free energy profiles of the Menschutkin reaction (H3N + CH3Cl --> +H3NCH3 + Cl-) in the presence and absence of the solvent water via FMO-MD. The obtained free energy profiles were consistent with the Hammond postulate in that stabilization of the product by the solvent, namely hydration of Cl-, shifted the transition state to the reactant-side. Based on these FMO-MD results, plans for further improvement of the method are discussed. Copyright 2008 Wiley Periodicals, Inc.

  7. Humanized TLR4/MD-2 mice reveal LPS recognition differentially impacts susceptibility to Yersinia pestis and Salmonella enterica.

    Directory of Open Access Journals (Sweden)

    Adeline M Hajjar

    Full Text Available Although lipopolysaccharide (LPS stimulation through the Toll-like receptor (TLR-4/MD-2 receptor complex activates host defense against Gram-negative bacterial pathogens, how species-specific differences in LPS recognition impact host defense remains undefined. Herein, we establish how temperature dependent shifts in the lipid A of Yersinia pestis LPS that differentially impact recognition by mouse versus human TLR4/MD-2 dictate infection susceptibility. When grown at 37°C, Y. pestis LPS is hypo-acylated and less stimulatory to human compared with murine TLR4/MD-2. By contrast, when grown at reduced temperatures, Y. pestis LPS is more acylated, and stimulates cells equally via human and mouse TLR4/MD-2. To investigate how these temperature dependent shifts in LPS impact infection susceptibility, transgenic mice expressing human rather than mouse TLR4/MD-2 were generated. We found the increased susceptibility to Y. pestis for "humanized" TLR4/MD-2 mice directly paralleled blunted inflammatory cytokine production in response to stimulation with purified LPS. By contrast, for other Gram-negative pathogens with highly acylated lipid A including Salmonella enterica or Escherichia coli, infection susceptibility and the response after stimulation with LPS were indistinguishable between mice expressing human or mouse TLR4/MD-2. Thus, Y. pestis exploits temperature-dependent shifts in LPS acylation to selectively evade recognition by human TLR4/MD-2 uncovered with "humanized" TLR4/MD-2 transgenic mice.

  8. Electrical grounding prong socket

    Science.gov (United States)

    Leong, Robert

    1991-01-01

    The invention is a socket for a grounding prong used in a three prong electrical plug and a receptacle for the three prong plug. The socket being sufficiently spacious to prevent the socket from significantly stretching when a larger, U-shaped grounding prong is inserted into the socket, and having a ridge to allow a snug fit when a smaller tubular shape grounding prong is inserted into the socket.

  9. Representation of bidirectional ground motions for design spectra in building codes

    Science.gov (United States)

    Stewart, Jonathan P.; Abrahamson, Norman A.; Atkinson, Gail M.; Beker, Jack W.; Boore, David M.; Bozorgnia, Yousef; Campbell, Kenneth W.; Comartin, Craig D.; Idriss, I.M.; Lew, Marshall; Mehrain, Michael; Moehle, Jack P.; Naeim, Farzad; Sabol, Thomas A.

    2011-01-01

    The 2009 NEHRP Provisions modified the definition of horizontal ground motion from the geometric mean of spectral accelerations for two components to the peak response of a single lumped mass oscillator regardless of direction. These maximum-direction (MD) ground motions operate under the assumption that the dynamic properties of the structure (e.g., stiffness, strength) are identical in all directions. This assumption may be true for some in-plan symmetric structures, however, the response of most structures is dominated by modes of vibration along specific axes (e.g., longitudinal and transverse axes in a building), and often the dynamic properties (especially stiffness) along those axes are distinct. In order to achieve structural designs consistent with the collapse risk level given in the NEHRP documents, we argue that design spectra should be compatible with expected levels of ground motion along those principal response axes. The use of MD ground motions effectively assumes that the azimuth of maximum ground motion coincides with the directions of principal structural response. Because this is unlikely, design ground motions have lower probability of occurrence than intended, with significant societal costs. We recommend adjustments to make design ground motions compatible with target risk levels.

  10. From nature to grounding

    OpenAIRE

    Jago, Mark

    2011-01-01

    Grounding is a powerful metaphysical concept; yet there is widespread scepticism about the intelligibility of the notion. In this paper, I propose an account of an entity’s nature or essence, which I then use to provide grounding conditions for that entity. I claim that an understanding of an entity’s nature, together with an account of how logically complex entities are grounded, provides all we need to understand how that entity is grounded. This approach not only allows us to say what grou...

  11. Proving the infringement of digital intellectual property rights: Overview of the Anglo-saxon legal system

    Directory of Open Access Journals (Sweden)

    Spasić Vidoje

    2015-01-01

    Full Text Available The multifaceted process of identifying and proving the infringement of intellectual property rights is further complicated and aggravated in the so-called analogue environment. The development of Information Technologies has given rise to a new set of problems. The digital technology has facilitated the infringement of intellectual property rights and additionally aggravated the process of proving these infringements. Hence, it is the duty of digital forensics to identify relevant (valid evidence and present it in the court of law, which is not an easy task. In that course, the problems are twofold: legal and technical. First of all, the legislation in many countries is not adjusted to resolving the issues constantly emerging in the digital environment and there are apparent differences in the manner of regulating these issues. On the other hand, there is no standardized and unified technology which would provide for a uniform qualification and comprehensive treatment of these issues. Moreover, the place of commission of these criminal offences as a rule does not coincide with the place of occurring legal consequences. Yet, in spite of all these difficulties, there are technological methods and tools which facilitate the detection of cybercrime and provide evidence for securing relevant punishment. In the time to come, the developments in this area are expected to be aimed at strengthening the protection of legitimate interests of holders of intellectual property rights.

  12. Heat Flow Data Cruise MD72 RV Marion Dufresne over the Mascarene Ridge

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Data were gathered by the R/V Marion Dufresne in May and June of 1992 over the Mascarene Ridge in the Indian Ocean on cruise MD72/MASCAFLUX. Heat flow measurements...

  13. Property values, parks, and crime: a hedonic analysis in Baltimore, MD

    Science.gov (United States)

    Austin Troy; J. Morgan Grove

    2008-01-01

    While urban parks are generally considered to be a positive amenity, past research suggests that some parks are perceived as a neighborhood liability. Using hedonic analysis of property data in Baltimore, MD, we attempted to determine whether crime rate mediates how parks are valued by the housing market. Transacted price was regressed against park proximity, area-...

  14. Vienna-PTM web server: a toolkit for MD simulations of protein post-translational modifications.

    Science.gov (United States)

    Margreitter, Christian; Petrov, Drazen; Zagrovic, Bojan

    2013-07-01

    Post-translational modifications (PTMs) play a key role in numerous cellular processes by directly affecting structure, dynamics and interaction networks of target proteins. Despite their importance, our understanding of protein PTMs at the atomistic level is still largely incomplete. Molecular dynamics (MD) simulations, which provide high-resolution insight into biomolecular function and underlying mechanisms, are in principle ideally suited to tackle this problem. However, because of the challenges associated with the development of novel MD parameters and a general lack of suitable computational tools for incorporating PTMs in target protein structures, MD simulations of post-translationally modified proteins have historically lagged significantly behind the studies of unmodified proteins. Here, we present Vienna-PTM web server (http://vienna-ptm.univie.ac.at), a platform for automated introduction of PTMs of choice to protein 3D structures (PDB files) in a user-friendly visual environment. With 256 different enzymatic and non-enzymatic PTMs available, the server performs geometrically realistic introduction of modifications at sites of interests, as well as subsequent energy minimization. Finally, the server makes available force field parameters and input files needed to run MD simulations of modified proteins within the framework of the widely used GROMOS 54A7 and 45A3 force fields and GROMACS simulation package.

  15. Novel plasmid conferring kanamycin and tetracycline resistance in turkey-derived Campylobacter jejuni strain 11601MD

    Science.gov (United States)

    In Campylobacter spp., resistance to the antibiotics kanamycin and tetracycline is frequently associated with plasmid-borne genes. However, relatively few plasmids of Campylobacter jejuni have been fully characterized to date. A novel plasmid (p11601MD; 44,095 bp.) harboring tet(O) was identified in...

  16. Data of evolutionary structure change: 1AHPA-2C4MD [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1AHPA-2C4MD 1AHP 2C4M A D SQPIFNDKQFQEALSRQWQRYGLNSAAEMTPRQWWLAVSEALAEMLRAQ--PFAKP...1AHP A 1AHPA MLRAQ--PFAKP...1AHP A 1AHPA SLQKE-WANDL ...1AHP A 1AHPA LHSIG----KQGGD...1AHP A 1AHPA DVLYR-DQEAW

  17. MD-SeeGH: a platform for integrative analysis of multi-dimensional genomic data

    Directory of Open Access Journals (Sweden)

    Ng Raymond T

    2008-05-01

    Full Text Available Abstract Background Recent advances in global genomic profiling methodologies have enabled multi-dimensional characterization of biological systems. Complete analysis of these genomic profiles require an in depth look at parallel profiles of segmental DNA copy number status, DNA methylation state, single nucleotide polymorphisms, as well as gene expression profiles. Due to the differences in data types it is difficult to conduct parallel analysis of multiple datasets from diverse platforms. Results To address this issue, we have developed an integrative genomic analysis platform MD-SeeGH, a software tool that allows users to rapidly and directly analyze genomic datasets spanning multiple genomic experiments. With MD-SeeGH, users have the flexibility to easily update datasets in accordance with new genomic builds, make a quality assessment of data using the filtering features, and identify genetic alterations within single or across multiple experiments. Multiple sample analysis in MD-SeeGH allows users to compare profiles from many experiments alongside tracks containing detailed localized gene information, microRNA, CpG islands, and copy number variations. Conclusion MD-SeeGH is a new platform for the integrative analysis of diverse microarray data, facilitating multiple profile analyses and group comparisons.

  18. Molecular Dynamics Fingerprints (MDFP): Machine Learning from MD Data To Predict Free-Energy Differences.

    Science.gov (United States)

    Riniker, Sereina

    2017-04-24

    While the use of machine-learning (ML) techniques is well established in cheminformatics for the prediction of physicochemical properties and binding affinities, the training of ML models based on data from molecular dynamics (MD) simulations remains largely unexplored. Here, we present a fingerprint termed MDFP which is constructed from the distributions of properties such as potential-energy components, radius of gyration, and solvent-accessible surface area extracted from MD simulations. The corresponding fingerprint elements are the first two statistical moments of the distributions and the median. By considering not only the average but also the spread of the distribution in the fingerprint, some degree of entropic information is encoded. Short MD simulations of the molecules in water (and in vacuum) are used to generate MDFP. These are further combined with simple counts based on the 2D structure of the molecules into MDFP+. The resulting information-rich MDFP+ is used to train ML models for the prediction of solvation free energies in five different solvents (water, octanol, chloroform, hexadecane, and cyclohexane) as well as partition coefficients in octanol/water, hexadecane/water, and cyclohexane/water. The approach is easy to implement and computationally relatively inexpensive. Yet, it performs similarly well compared to more rigorous MD-based free-energy methods such as free-energy perturbation (FEP) as well as end-state methods such as linear interaction energy (LIE), the conductor-like screening model for realistic solvation (COSMO-RS), and the SMx family of solvation models.

  19. Short Chosen-Prefix Collisions for MD5 and the Creation of a Rogue CA Certificate

    NARCIS (Netherlands)

    M.M.J. Stevens (Marc); A. Sotirov (Alexander); J. Appelbaum; A.K. Lenstra (Arjen); D. Molnar; D.A. Osvik; B. de Weger (Benne)

    2009-01-01

    textabstractWe present a refined chosen-prefix collision construction for MD5 that allowed creation of a rogue Certification Authority (CA) certificate, based on a collision with a regular end-user website certificate provided by a commercial CA. Compared to the previous construction from Eurocrypt

  20. 75 FR 18778 - Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD

    Science.gov (United States)

    2010-04-13

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast Guard proposes establishing a temporary safety zone on the Atlantic Ocean in the vicinity of Ocean City, Maryland...

  1. 76 FR 20008 - Notice of Temporary Concession Contract for Assateague Island National Seashore, MD

    Science.gov (United States)

    2011-04-11

    ... merchandise and limited pre-packaged food and beverage. This action is necessary to avoid interruption of... National Park Service Notice of Temporary Concession Contract for Assateague Island National Seashore, MD AGENCY: National Park Service, Interior. ACTION: Notice of proposed award of temporary concession...

  2. 77 FR 3118 - Security Zone; Choptank River and Cambridge Channel, Cambridge, MD

    Science.gov (United States)

    2012-01-23

    ... No. USCG-2011-1164] RIN 1625-AA87 Security Zone; Choptank River and Cambridge Channel, Cambridge, MD... temporary security zone encompassing certain waters of the Choptank River and Cambridge Channel in order to... will be held at the Hyatt Regency Chesapeake Bay Golf Resort, Spa and Marina in Cambridge, Maryland...

  3. 76 FR 16823 - Robert L. Dougherty, M.D.; Denial of Application

    Science.gov (United States)

    2011-03-25

    ... Enforcement Administration Robert L. Dougherty, M.D.; Denial of Application On March 16, 2009, the Deputy... Order proposed the denial of Respondent's pending application for a DEA Certificate of Registration as a... Respondent's ``mis-judgments were well intentioned.'' Id. at 22-24. Next, the ALJ reasoned that ``there was...

  4. Going Concern Opinions and Management's Forward Looking Disclosures: Evidence from the MD&A

    NARCIS (Netherlands)

    Enev, M.; Geiger, Marshall; Gold, A.H.; Wallage, P.

    In this study we examine the relationship between the auditor’s going concern opinion and management’s forward-looking disclosures in the Management’s Discussion and Analysis (MD&A) section of 10-K filings. The research objective is two-fold and addresses whether the presence of a going concern

  5. LaSalle D. Leffall, M.D., FACS and Leadership in American Surgery.

    Science.gov (United States)

    Britt, L D

    2017-12-12

    The term, Festschrift, is defined as a volume of learned articles or essays by colleagues and admirers, serving as a tribute to a scholar. The recognition of LaSalle D. Leffall, Jr., M.D., F.A.C.S. adds credence to the merits of such a tribute. Copyright © 2017 Elsevier Inc. All rights reserved.

  6. 75 FR 24799 - Special Local Regulations for Marine Events; Chester River, Chestertown, MD; Correction

    Science.gov (United States)

    2010-05-06

    ... SECURITY Coast Guard 33 CFR Part 100 RIN 1625-AA08 Special Local Regulations for Marine Events; Chester... information about the original regulation, contact Mr. Ronald Houck, Sector Baltimore Waterways Management... event to be held on the waters of the Chester River, Chestertown, MD on May 29, 2010. The special local...

  7. 77 FR 47279 - Special Local Regulations for Marine Events, Patuxent River; Solomons, MD

    Science.gov (United States)

    2012-08-08

    ... understanding this rule. If the rule would affect your small business, organization, or governmental... establishing special local regulations during the ``Chesapeake Challenge'' power boat races, a marine event to... Chesapeake Bay Power Boat Association will sponsor power boat races on the Patuxent River near Solomons, MD...

  8. A. G. Hill, MBChB, MD, FRACS, Department of Surgery, Africa Inland ...

    African Journals Online (AJOL)

    2002-01-01

    Jan 1, 2002 ... A. G. Hill, MBChB, MD, FRACS, Department of Surgery, Africa Inland Church Kijabe Hospital, P.O. Box 20, Kijabe, Kenya. MAJOR SALIVARY GLAND TUMOURS IN A RURAL KENYAN HOSPITAL. A. G. HILL. ABSTRACT. Background: Salivary gland tumours are not well characterised in Africa. The Kijabe.

  9. 78 FR 62666 - Kenneth Harold Bull, M.D.; Decision and Order

    Science.gov (United States)

    2013-10-22

    ... to 100 patients for opiate addiction with Suboxone and Subutex under the Drug Addiction Treatment Act... Show Cause to Kenneth Harold Bull, M.D. (Respondent), of Albuquerque, New Mexico. ALJ Ex. 1. The Show... because of actions taken by the New Mexico Medical Board, Respondent was without authority to handle...

  10. A mathematic model that describes modes of MdSGHV transmission within house fly populations

    Science.gov (United States)

    In this paper it is proposed that one potential component by which the Musca domestica salivary gland hypertrophy virus (MdSGHV) infects individual flies is through cuticular damage. Breaks in the cuticle allow entry of the virus into the hemocoel causing the infection. Male flies typically have a h...

  11. 76 FR 16821 - Gregory F. Saric, M.D.; Decision and Order

    Science.gov (United States)

    2011-03-25

    ... similar to that of Respondent's.'' Exceptions at 1 (citing Stuart A. Bergman, M.D., 70 FR 33193 (2005)). Respondent notes that `` n Bergman , the ALJ delayed issuing her ruling on the Government's Motion for... under law to dispense a controlled substance.''). Thus, Respondent's reliance on Bergman is misplaced.\\2...

  12. 76 FR 70647 - Safety Zone; Fireworks Display, Potomac River, National Harbor Access Channel, MD

    Science.gov (United States)

    2011-11-15

    ... Harbor Access Channel, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast... floating platform located within the National Harbor Access Channel, in Prince Georges County, Maryland... Access Channel, within a 50 yards radius of a fireworks discharge platform in approximate position...

  13. 77 FR 20750 - Special Local Regulations for Marine Events; Potomac River, National Harbor Access Channel, MD

    Science.gov (United States)

    2012-04-06

    ... River, National Harbor Access Channel, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed... temporarily restrict vessel traffic in a portion of the Potomac River and National Harbor Access Channel... Access Channel from 6 a.m. to 10 a.m. The sponsor has stated that this marine event is not expected to be...

  14. 78 FR 20849 - Special Local Regulations; Marine Events, Potomac River; National Harbor Access Channel, MD

    Science.gov (United States)

    2013-04-08

    ...; National Harbor Access Channel, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY... Potomac River federal navigation channel and the National Harbor Access Channel. C. Discussion of Proposed... Harbor Access Channel and includes the waters of the Potomac River, from shoreline to shoreline, bounded...

  15. 77 FR 25106 - Special Local Regulations for Marine Events; Potomac River, National Harbor Access Channel, MD

    Science.gov (United States)

    2012-04-27

    ... River, National Harbor Access Channel, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed... navigation channel and the National Harbor Access Channel. Due to the need for vessel control during the... through the regulated area, including the National Harbor Access Channel, will only be allowed to safely...

  16. 75 FR 12563 - Patuxent Research Refuge, Anne Arundel and Prince George's Counties, MD

    Science.gov (United States)

    2010-03-16

    ... Scarlet Tanager Loop, Laurel, MD 20708. FOR FURTHER INFORMATION CONTACT: Brad Knudsen, Refuge Manager... developing a CCP is to provide refuge managers with a 15-year plan for achieving refuge purposes and... team leader or project leader (see ADDRESSES). You may also send comments anytime during the planning...

  17. The draft genome of MD-2 pineapple using hybrid error correction of long reads.

    Science.gov (United States)

    Redwan, Raimi M; Saidin, Akzam; Kumar, S Vijay

    2016-07-03

    The introduction of the elite pineapple variety, MD-2, has caused a significant market shift in the pineapple industry. Better productivity, overall increased in fruit quality and taste, resilience to chilled storage and resistance to internal browning are among the key advantages of the MD-2 as compared with its previous predecessor, the Smooth Cayenne. Here, we present the genome sequence of the MD-2 pineapple (Ananas comosus (L.) Merr.) by using the hybrid sequencing technology from two highly reputable platforms, i.e. the PacBio long sequencing reads and the accurate Illumina short reads. Our draft genome achieved 99.6% genome coverage with 27,017 predicted protein-coding genes while 45.21% of the genome was identified as repetitive elements. Furthermore, differential expression of ripening RNASeq library of pineapple fruits revealed ethylene-related transcripts, believed to be involved in regulating the process of non-climacteric pineapple fruit ripening. The MD-2 pineapple draft genome serves as an example of how a complex heterozygous genome is amenable to whole genome sequencing by using a hybrid technology that is both economical and accurate. The genome will make genomic applications more feasible as a medium to understand complex biological processes specific to pineapple. © The Author 2016. Published by Oxford University Press on behalf of Kazusa DNA Research Institute.

  18. Identification of key residues that confer Rhodobacter sphaeroides LPS activity at horse TLR4/MD-2.

    Directory of Open Access Journals (Sweden)

    Katherine L Irvine

    Full Text Available The molecular determinants underpinning how hexaacylated lipid A and tetraacylated precursor lipid IVa activate Toll-like receptor 4 (TLR4 are well understood, but how activation is induced by other lipid A species is less clear. Species specificity studies have clarified how TLR4/MD-2 recognises different lipid A structures, for example tetraacylated lipid IVa requires direct electrostatic interactions for agonism. In this study, we examine how pentaacylated lipopolysaccharide from Rhodobacter sphaeroides (RSLPS antagonises human TLR4/MD-2 and activates the horse receptor complex using a computational approach and cross-species mutagenesis. At a functional level, we show that RSLPS is a partial agonist at horse TLR4/MD-2 with greater efficacy than lipid IVa. These data suggest the importance of the additional acyl chain in RSLPS signalling. Based on docking analysis, we propose a model for positioning of the RSLPS lipid A moiety (RSLA within the MD-2 cavity at the TLR4 dimer interface, which allows activity at the horse receptor complex. As for lipid IVa, RSLPS agonism requires species-specific contacts with MD-2 and TLR4, but the R2 chain of RSLA protrudes from the MD-2 pocket to contact the TLR4 dimer in the vicinity of proline 442. Our model explains why RSLPS is only partially dependent on horse TLR4 residue R385, unlike lipid IVa. Mutagenesis of proline 442 into a serine residue, as found in human TLR4, uncovers the importance of this site in RSLPS signalling; horse TLR4 R385G/P442S double mutation completely abolishes RSLPS activity without its counterpart, human TLR4 G384R/S441P, being able to restore it. Our data highlight the importance of subtle changes in ligand positioning, and suggest that TLR4 and MD-2 residues that may not participate directly in ligand binding can determine the signalling outcome of a given ligand. This indicates a cooperative binding mechanism within the receptor complex, which is becoming increasingly

  19. Identification of key residues that confer Rhodobacter sphaeroides LPS activity at horse TLR4/MD-2.

    Science.gov (United States)

    Irvine, Katherine L; Gangloff, Monique; Walsh, Catherine M; Spring, David R; Gay, Nicholas J; Bryant, Clare E

    2014-01-01

    The molecular determinants underpinning how hexaacylated lipid A and tetraacylated precursor lipid IVa activate Toll-like receptor 4 (TLR4) are well understood, but how activation is induced by other lipid A species is less clear. Species specificity studies have clarified how TLR4/MD-2 recognises different lipid A structures, for example tetraacylated lipid IVa requires direct electrostatic interactions for agonism. In this study, we examine how pentaacylated lipopolysaccharide from Rhodobacter sphaeroides (RSLPS) antagonises human TLR4/MD-2 and activates the horse receptor complex using a computational approach and cross-species mutagenesis. At a functional level, we show that RSLPS is a partial agonist at horse TLR4/MD-2 with greater efficacy than lipid IVa. These data suggest the importance of the additional acyl chain in RSLPS signalling. Based on docking analysis, we propose a model for positioning of the RSLPS lipid A moiety (RSLA) within the MD-2 cavity at the TLR4 dimer interface, which allows activity at the horse receptor complex. As for lipid IVa, RSLPS agonism requires species-specific contacts with MD-2 and TLR4, but the R2 chain of RSLA protrudes from the MD-2 pocket to contact the TLR4 dimer in the vicinity of proline 442. Our model explains why RSLPS is only partially dependent on horse TLR4 residue R385, unlike lipid IVa. Mutagenesis of proline 442 into a serine residue, as found in human TLR4, uncovers the importance of this site in RSLPS signalling; horse TLR4 R385G/P442S double mutation completely abolishes RSLPS activity without its counterpart, human TLR4 G384R/S441P, being able to restore it. Our data highlight the importance of subtle changes in ligand positioning, and suggest that TLR4 and MD-2 residues that may not participate directly in ligand binding can determine the signalling outcome of a given ligand. This indicates a cooperative binding mechanism within the receptor complex, which is becoming increasingly important in TLR

  20. The Annual Conference on HAN (Hydroxylammonium Nitrate) Based Liquid Propellants (3rd) Held in Aberdeen Proving Ground, Maryland on 25-27 August 1987.

    Science.gov (United States)

    1988-03-01

    ELECTROKINETICS *MASS TRANSPORT/SEPARATION *PARALLEL PLATE REACTOR *CONCLUSIONS 168 THE REDOX PROPERTIES OF HYDROXYLAMMONIUM NITRATE [NH3OH] IN031 PROVIDE...30-9644 US Army ARDEC New Haven, CT 06511 Picatinny Arsenal, NJ (203) 785-5242 07806-5000 (201) 724-5378/4776 Marshall Humphrey Jet Propulsion Lab Jim... Propulsion Lab Peter Spohn 4800 Oak Grove Drive University of Delaware Pasadena, CA Chemistry Dept (818) 354-8078 Newark, DE 19711 (302) 451-2459 239

  1. Proceedings of the Annual Chemical Defense Bioscience Review (4th) Held at Aberdeen Proving Ground, Maryland on 30 May-1 June 1984

    Science.gov (United States)

    1984-06-01

    depression was accompanied by a persistent d oolarization of the endplate region. Recovery from depresion was observed after a 10 sec quiescent period...molecular forms (10) of human brain AChE have been reported in several neurological or genetic disorders, such as Alzheimer disease (11) or Down’s...Drosophila - . metanogaoteT. The genetics of the nervous system in Drosophila is well-characterized, and various mutants are available in which the

  2. Canal Creek Study Area, Aberdeen Proving Ground, Edgewood Area, Maryland. Groundwater Monitoring Plan, Final Quality Assurance Project Plan, Standard Operating Procedures (SOPs). Appendix A

    Science.gov (United States)

    1993-10-01

    Enclose each sample in a clear zip-seal plastic bag. 3.4 Place several layers of bubble wrap, or at least 1" of vermiculite on the bottom of the cooler...PTFE) liners * f. 5 % NaOH g. 5% Ultrex HNO 3 h. Deionized water i. Alconox detergent j. Hexane (Nanograde or equivalent) k. Acetone 1. Methelyne...Chloride 3.0 Procedures 3.1 Polyethylene bottles 3.1.1 Rinse bottles and lids sequentially with 5% NaOH , with deionized water, with 5% Ultrex nitric acid

  3. Beach Point Test Site, Aberdeen Proving Ground, Edgewood Area, Maryland. Focused Feasibility Study, Final Quality Assurance Project Plan, Standard Operating Procedures (SOPs). Appendix A

    Science.gov (United States)

    1993-10-01

    3.3 Enclose each sample in a clear zip-seal plastic bag. 3.4 Place several layers of bubble wrap, or at least 1" of vermiculite on the bottom of the...liners f. 5% NaOH g. 5% Ultrex HNO 3 h. Deionized water i. Alconox detergent j. Hexane (Nanograde or equivalent) k. Acetone 1. Methelyne Chloride 3.0...Procedures 3.1 Polyethylene bottles 3.1.1 Rinse bottles and lids sequentially with 5 % NaOH , with deionized water, with 5% Ultrex nitric acid, and

  4. Proceedings of the 1993 Scientific Conference on Obscuration and Aerosol Research Held in Aberdeen Proving Ground on 22-24 Jun 1993

    Science.gov (United States)

    1994-03-01

    other nations with resource management plans for economic and ecological stability and medical care and food distribution as well as optimal running of...in the paper of Frenklach, Wang. and Rabinowitz (129]) The paper of Smooke and Giovangigli ([70]) and Peters ([591) describe methane coi,’,b- sion. The...1981) [69] Smaller, Joel. Shock waves and reaceion diffusion equations New York: Springer Verlag (1983) [70] Smooke . Mitchell D. and Vincent

  5. Ideas from Future Technologies Workshop Held by ARL/TARDEC in Aberdeen Proving Ground, Maryland on 9-11 June, 1993

    Science.gov (United States)

    1994-08-01

    you’d have a stronger reverse EMF field to work on the gun. And, also as well, you may have a mechanical representation (you certainly wouldn’t do it...Philosophical Comments sections to facilitate reader digestion. The categories are not exclusive as we really wanted cross- fertilization of ideas...further developed to controVrnanage suspensions, recoil mechanisms . Use electroceramic-controlled orifices for active recoil systems or suspensions

  6. Evaluation of Several Biological Monitoring Techniques for Hazard Assessment of Potentially Contaminated Groundwater at the Old O-Field Site at the Edgewood Area of Aberdeen Proving Ground

    Science.gov (United States)

    1991-11-01

    precipitate as follows: CODE DEFINICION CHARACTERISTICS OF BACKGROUND LAWN 1 Normal A healthy microcolony lawn. 2 Slightly A noticeable thinning of...Microbial Mutagenesis Date Department of Mol -icular and Cellular Toxicology I I I I 14544-1-401X 3 I A2 -3 I HAZLEECr4J WASHINGTON TABLE OF CONTENTS

  7. Operation Upshot-Knothole, Nevada Proving Grounds, March-June 1953. Project 8.5. Thermal Radiation Protection Afforded Test Animals by Fabric Assemblies

    Science.gov (United States)

    1955-07-01

    wearing the Temperate uniform not treated for fire resistance sustained minor skin burns, but these resulted from exo- thermic reactions (flame or glow...number of ways, but they disappear rapidly. One method is to isolate the tar from the decomposition of fabric treated with brominated triallyl phosphate...3. The effect of the time-intensity relationship of thermal irradiation, the effect of smoke obscuration due to apparent endo- thermic decomposition

  8. Operational Use of the AIRS Total Column Ozone Retrievals Along with the RGB Air Mass Product as Part of the GOES-R Proving Ground

    Science.gov (United States)

    Folmer, Michael; Zavodsky, Bradley; Molthan, Andrew

    2012-01-01

    The National Oceanic and Atmospheric Administration (NOAA) National Centers for Environmental Prediction (NCEP) Hydrometeorological Prediction Center (HPC) and Ocean Prediction Center (OPC) provide short-term and medium-range forecast guidance of heavy precipitation, strong winds, and other features often associated with mid-latitude cyclones over both land and ocean. As a result, detection of factors that lead to rapid cyclogenesis and high wind events is key to improving forecast skill. One phenomenon that has been identified with these events is the stratospheric intrusion that occurs near tropopause folds. This allows for deep mixing near the top of the atmosphere where dry air high in ozone concentrations and potential vorticity descends (sometimes rapidly) deep into the mid-troposphere. Observations from satellites can aid in detection of these stratospheric air intrusions (SAI) regions. Specifically, multispectral composite imagery assign a variety of satellite spectral bands to the red, green, and blue (RGB) color components of imagery pixels and result in color combinations that can assist in the detection of dry stratospheric air associated with PV advection, which in turn may alert forecasters to the possibility of a rapidly strengthening storm system. Single channel or RGB satellite imagery lacks quantitative information about atmospheric moisture unless the sampled brightness temperatures or other data are converted to estimates of moisture via a retrieval process. Thus, complementary satellite observations are needed to capture a complete picture of a developing storm system. Here, total column ozone retrievals derived from a hyperspectral sounder are used to confirm the extent and magnitude of SAIs. Total ozone is a good proxy for defining locations and intensity of SAIs and has been used in studies evaluating that phenomenon (e.g. Tian et al. 2007, Knox and Schmidt 2005). Steep gradients in values of total ozone seen by satellites have been linked to stratosphere-troposphere exchange (WMO, 1985).

  9. The Annual Conference on Han-Based Liquid Propellants (5th) Held in Aberdeen Proving Ground on 22-24 August 1989

    Science.gov (United States)

    1990-06-01

    Herrington Pethybridge, and Roffey, "Density of Aqueous Lithium, Sodium, and Potassium Hydroxides from 25 to 75 deg C at 1 atm", J. Chem Eng. Data 1986, 31, 31...products development 4 Note: Titration - Typical acid-base titrimetry . IC - ion chromatography, ionic separation with a liquid eluant. SFC

  10. Proceedings of the Scientific Conference on Obscuration and Aerosol Research Held in Aberdeen Proving Ground, Maryland on 17-21 June 1985.

    Science.gov (United States)

    1986-07-01

    1 FOR DETERMINING COMPLEX PERMEABILITY AND PERMITTIVITY H. H. Chung, G. A. Pfaff, and S. Y. Peng % Teledyne Micronetics San Diego, California 92120...section 2. . lThis paper is based on work performed at Teledyne Micronetics under the Contract No. IAAKll-83-C-0011 for the Chemical/Ballistics...Thomas Witkowski, Director of Engineering at Teledyne Micronetics , for their support and encouragement. Thanks are also due to Ms. Laura Peck for her

  11. Proceedings of the Scientific Conference on Obscuration and Aerosol Research Held in Aberdeen Proving Ground, Maryland on June 22-25, 1992

    Science.gov (United States)

    1993-06-01

    Compatibility. Volume 30, Number 4 (November, 1988) pp 529 - 537. [50] Uhlenbeck, G. E. and L. S. Ornstein. "On the theory of Brownian Motion " Phys... multifractal nature of energy dissipation rate (Meneveau and Sreenivasan, 1987) and scalar dissipation rate (Prasad et al., 1988) in various turbulent flows...singularity spectrum F(a). The Fractal Dimension Db, is related to F(a) by Db = I - al + F(al), (1) where a, may be defined by F’(a,) = 1. A multifractal

  12. Operation IVY, Pacific Proving Ground, November 1952. Project 7.1. Electromagnetic Effects from Nuclear Explosions. Report to the Scientific Director

    Science.gov (United States)

    1958-01-31

    stations at vary- ing distances from the detonation points. Encouraging results were obtained, at distances up to 4,700 km, from radio goniometry ...as calculated above. If a reliable attenuation factor could be applied, one could estimate the total electromagnetic energy in the detonation at

  13. Proceedings of the Meeting of the Coordinating Group on Modern Control Theory (2nd) 10-11 December 1980, Aberdeen Proving Ground, Maryland. Part 1

    Science.gov (United States)

    1981-04-01

    autocorrelation coefficients by my program. so as to have compar:ible data), have been greatly reduced, Using the linear least chi-squarE pr gram :)n the same...t, dt (13) t 0 whwro S irnd Q are given syrmnet-ir non- negativo definite matrlices. S + Q poR i tivV dc,.knite, . to a positivedefinite matrix, and

  14. Pesticides in Ground Water

    DEFF Research Database (Denmark)

    Bjerg, Poul Løgstrup

    1996-01-01

    Review af: Jack E. Barbash & Elizabeth A. Resek (1996). Pesticides in Ground Water. Distribution trends and governing factors. Ann Arbor Press, Inc. Chelsea, Michigan. pp 588.......Review af: Jack E. Barbash & Elizabeth A. Resek (1996). Pesticides in Ground Water. Distribution trends and governing factors. Ann Arbor Press, Inc. Chelsea, Michigan. pp 588....

  15. Efektivitas Instagram Common Grounds

    OpenAIRE

    Wifalin, Michelle

    2016-01-01

    Efektivitas Instagram Common Grounds merupakan rumusan masalah yang diambil dalam penelitian ini. Efektivitas Instagram diukur menggunakan Customer Response Index (CRI), dimana responden diukur dalam berbagai tingkatan, mulai dari awareness, comprehend, interest, intentions dan action. Tingkatan respons inilah yang digunakan untuk mengukur efektivitas Instagram Common Grounds. Teori-teori yang digunakan untuk mendukung penelitian ini yaitu teori marketing Public Relations, teori iklan, efekti...

  16. Decentralized Ground Staff Scheduling

    DEFF Research Database (Denmark)

    Sørensen, M. D.; Clausen, Jens

    2002-01-01

    Typically, ground staff scheduling is centrally planned for each terminal in an airport. The advantage of this is that the staff is efficiently utilized, but a disadvantage is that staff spends considerable time walking between stands. In this paper a decentralized approach for ground staff...

  17. Communication, concepts and grounding.

    Science.gov (United States)

    van der Velde, Frank

    2015-02-01

    This article discusses the relation between communication and conceptual grounding. In the brain, neurons, circuits and brain areas are involved in the representation of a concept, grounding it in perception and action. In terms of grounding we can distinguish between communication within the brain and communication between humans or between humans and machines. In the first form of communication, a concept is activated by sensory input. Due to grounding, the information provided by this communication is not just determined by the sensory input but also by the outgoing connection structure of the conceptual representation, which is based on previous experiences and actions. The second form of communication, that between humans or between humans and machines, is influenced by the first form. In particular, a more successful interpersonal communication might require forms of situated cognition and interaction in which the entire representations of grounded concepts are involved. Copyright © 2014 Elsevier Ltd. All rights reserved.

  18. The Grounded Theory Bookshelf

    Directory of Open Access Journals (Sweden)

    Dr. Alvita Nathaniel, DSN, APRN, BC

    2005-06-01

    Full Text Available The Grounded Theory Perspective III: Theoretical Coding, Barney G. Glaser (Sociology Press, 2005. Not intended for a beginner, this book further defi nes, describes, and explicates the classic grounded theory (GT method. Perspective III lays out various facets of theoretical coding as Glaser meticulously distinguishes classic GT from other subsequent methods. Developed many years after Glaser’s classic GT, these methods, particularly as described by Strauss and Corbin, adopt the grounded theory name and engender ongoing confusion about the very premises of grounded theory. Glaser distinguishes between classic GT and the adscititious methods in his writings, referring to remodeled grounded theory and its offshoots as Qualitative Data Analysis (QDA models.

  19. A theorem proving framework for the formal verification of Web Services Composition

    Directory of Open Access Journals (Sweden)

    Petros Papapanagiotou

    2011-08-01

    Full Text Available We present a rigorous framework for the composition of Web Services within a higher order logic theorem prover. Our approach is based on the proofs-as-processes paradigm that enables inference rules of Classical Linear Logic (CLL to be translated into pi-calculus processes. In this setting, composition is achieved by representing available web services as CLL sentences, proving the requested composite service as a conjecture, and then extracting the constructed pi-calculus term from the proof. Our framework, implemented in HOL Light, not only uses an expressive logic that allows us to incorporate multiple Web Services properties in the composition process, but also provides guarantees of soundness and correctness for the composition.

  20. Myoid hamartoma of the breast that proved difficult to diagnose: a case report

    Directory of Open Access Journals (Sweden)

    Mizuta Naruhiko

    2012-01-01

    Full Text Available Abstract Myoid hamartomas of the breast are extremely rare breast lesions, with a poorly understood pathogenesis. We describe the case of a 38-year-old premenopausal woman who presenting with a mass in the left breast. Mammography revealed an oval mass that was partly indistinct, and ultrasonography showed a hypoechoic mass with a slightly irregular margin. Bilateral breast dynamic magnetic resonance imaging was performed for a more detailed evaluation. The images showed rapid initial enhancement and a microlobulated margin. Because the suspicion of malignancy was strong at that time, core needle biopsy was performed. Histologically, the tumor was identified as fibroadenoma. A case of myoid hamartoma of the breast that proved difficult to diagnose is reported, and discussed with reference to the literature.

  1. Calculus using proximities: a mathematical approach in which students can actually prove theorems

    Directory of Open Access Journals (Sweden)

    O’Donovan Richard

    2017-02-01

    Full Text Available Teaching and learning calculus are notoriously difficult and the didactic solutions may involve resorting to intuitive but vague definitions or informal gestures offered as proofs. The teaching literature is rife with examples of metaphors, adverb manipulations and descriptions of what happens “just before” the limit. It is then difficult to leave the domain of the mental image, thus losing the training in rigour. The author (with Karel Hrbacek and Olivier Lessmann has endeavoured a radically different approach with the objective of training students to prove theorems while preserving both intuition and mathematical rigour. Hence we change the mathematical setting rather than the didactic setting. The result (which is a by-product of nonstandard analysis has been used in several high schools in Geneva – Switzerland – for over ten years.

  2. An Abstract Model for Proving Safety of Multi-lane Traffic Manoeuvres

    DEFF Research Database (Denmark)

    Hilscher, Martin; Linker, Sven; Olderog, Ernst-Rüdiger

    2011-01-01

    We present an approach to prove safety (collision freedom) of multi-lane motorway traffic with lane-change manoeuvres. This is ultimately a hybrid verification problem due to the continuous dynamics of the cars. We abstract from the dynamics by introducing a new spatial interval logic based...... on the view of each car. To guarantee safety, we present two variants of a lane-change controller, one with perfect knowledge of the safety envelopes of neighbouring cars and one which takes only the size of the neighbouring cars into account. Based on these controllers we provide a local safety proof...... for unboundedly many cars by showing that at any moment the reserved space of each car is disjoint from the reserved space of any other car....

  3. Fractal geometry as a new approach for proving nanosimilarity: a reflection note.

    Science.gov (United States)

    Demetzos, Costas; Pippa, Natassa

    2015-04-10

    Nanosimilars are considered as new medicinal outcomes combining the generic drugs and the nanocarrier as an innovative excipient, in order to evaluate them as final products. They belong to the grey area - concerning the evaluation process - between generic drugs and biosimilar medicinal products. Generic drugs are well documented and a huge number of them are in market, replacing effectively the off-patent drugs. The scientific approach for releasing them to the market is based on bioequivalence studies, which are well documented and accepted by the regulatory agencies. On the other hand, the structural complexity of biological/biotechnology-derived products demands a new approach for the approval process taking into consideration that bioequivalence studies are not considered as sufficient as in generic drugs, and new clinical trials are needed to support their approval process of the product to the market. In proportion, due to technological complexity of nanomedicines, the approaches for proving the statistical identity or the similarity for generic and biosimilar products, respectively, with those of prototypes, are not considered as effective for nanosimilar products. The aim of this note is to propose a complementary approach which can provide realistic evidences concerning the nanosimilarity, based on fractal analysis. This approach is well fit with the structural complexity of nanomedicines and smooths the difficulties for proving the similarity between off-patent and nanosimilar products. Fractal analysis could be considered as the approach that completely characterizes the physicochemical/morphological characteristics of nanosimilar products and could be proposed as a start point for a deep discussion on nanosimilarity. Copyright © 2015 Elsevier B.V. All rights reserved.

  4. Fake News: A Technological Approach to Proving the Origins of Content, Using Blockchains.

    Science.gov (United States)

    Huckle, Steve; White, Martin

    2017-12-01

    In this article, we introduce a prototype of an innovative technology for proving the origins of captured digital media. In an era of fake news, when someone shows us a video or picture of some event, how can we trust its authenticity? It seems that the public no longer believe that traditional media is a reliable reference of fact, perhaps due, in part, to the onset of many diverse sources of conflicting information, via social media. Indeed, the issue of "fake" reached a crescendo during the 2016 U.S. Presidential Election, when the winner, Donald Trump, claimed that The New York Times was trying to discredit him by pushing disinformation. Current research into overcoming the problem of fake news does not focus on establishing the ownership of media resources used in such stories-the blockchain-based application introduced in this article is technology that is capable of indicating the authenticity of digital media. Put simply, using the trust mechanisms of blockchain technology, the tool can show, beyond doubt, the provenance of any source of digital media, including images used out of context in attempts to mislead. Although the application is an early prototype and its capability to find fake resources is somewhat limited, we outline future improvements that would overcome such limitations. Furthermore, we believe that our application (and its use of blockchain technology and standardized metadata) introduces a novel approach to overcoming falsities in news reporting and the provenance of media resources used therein. However, while our application has the potential to be able to verify the originality of media resources, we believe that technology is only capable of providing a partial solution to fake news. That is because it is incapable of proving the authenticity of a news story as a whole. We believe that takes human skills.

  5. 78 FR 72001 - Amendment of Class D and E Airspace, and Establishment of Class E Airspace; Salisbury, MD

    Science.gov (United States)

    2013-12-02

    ... Class E Airspace; Salisbury, MD AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class D and Class E airspace, and establishes Class E airspace at Salisbury-Ocean City Wicomico Regional Airport, Salisbury, MD, due to the decommissioning of the Salisbury VHF...

  6. 78 FR 52109 - Proposed Amendment of Class D and E Airspace, and Establishment of Class E Airspace; Salisbury, MD

    Science.gov (United States)

    2013-08-22

    ... Establishment of Class E Airspace; Salisbury, MD AGENCY: Federal Aviation Administration (FAA), DOT. ACTION..., and establish Class E airspace at Salisbury-Ocean City Wicomico Regional Airport, Salisbury, MD, due to the decommissioning of the Salisbury VHF Omnidirectional Radio Range Tactical Air Navigation Aid...

  7. 33 CFR 334.155 - Severn River, Naval Station Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area.

    Science.gov (United States)

    2010-07-01

    ... Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area. 334.155 Section 334.155 Navigation and... RESTRICTED AREA REGULATIONS § 334.155 Severn River, Naval Station Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area. (a) The area. The waters within the Naval Station Annapolis small boat basin and...

  8. DMPD: Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 15051069 Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. Miy...ake K. Trends Microbiol. 2004 Apr;12(4):186-92. (.png) (.svg) (.html) (.csml) Show Innate recognition of lipopolysaccharide... by Toll-like receptor 4-MD-2. PubmedID 15051069 Title Innate recognition of lipopolysaccharide

  9. 33 CFR 334.160 - Severn River, at U.S. Naval Academy Santee Basin, Annapolis, Md.; naval restricted area.

    Science.gov (United States)

    2010-07-01

    ... Academy Santee Basin, Annapolis, Md.; naval restricted area. 334.160 Section 334.160 Navigation and... RESTRICTED AREA REGULATIONS § 334.160 Severn River, at U.S. Naval Academy Santee Basin, Annapolis, Md.; naval restricted area. (a) The area. The waters within the U.S. Naval Academy Santee Basin and adjacent waters of...

  10. The Convergence of Business and Medicine: A Study of MD/MBA Programs in the United States

    Science.gov (United States)

    Keogh, Timothy J.; Martin, William Marty

    2011-01-01

    The purpose of this paper is to identify the convergence of business and medical education and describe the curricula of MD/MBA (Medical Doctor/Master of Business Administration) programs in the US. The focus of this study is to provide a guide to dual MD/MBA programs for physicians, aspiring physicians, policy makers and healthcare organizations.…

  11. RysannMD: A biomedical semantic annotator balancing speed and accuracy.

    Science.gov (United States)

    Cuzzola, John; Jovanović, Jelena; Bagheri, Ebrahim

    2017-07-01

    Recently, both researchers and practitioners have explored the possibility of semantically annotating large and continuously evolving collections of biomedical texts such as research papers, medical reports, and physician notes in order to enable their efficient and effective management and use in clinical practice or research laboratories. Such annotations can be automatically generated by biomedical semantic annotators - tools that are specifically designed for detecting and disambiguating biomedical concepts mentioned in text. The biomedical community has already presented several solid automated semantic annotators. However, the existing tools are either strong in their disambiguation capacity, i.e., the ability to identify the correct biomedical concept for a given piece of text among several candidate concepts, or they excel in their processing time, i.e., work very efficiently, but none of the semantic annotation tools reported in the literature has both of these qualities. In this paper, we present RysannMD (Ryerson Semantic Annotator for Medical Domain), a biomedical semantic annotation tool that strikes a balance between processing time and performance while disambiguating biomedical terms. In other words, RysannMD provides reasonable disambiguation performance when choosing the right sense for a biomedical term in a given context, and does that in a reasonable time. To examine how RysannMD stands with respect to the state of the art biomedical semantic annotators, we have conducted a series of experiments using standard benchmarking corpora, including both gold and silver standards, and four modern biomedical semantic annotators, namely cTAKES, MetaMap, NOBLE Coder, and Neji. The annotators were compared with respect to the quality of the produced annotations measured against gold and silver standards using precision, recall, and F1 measure and speed, i.e., processing time. In the experiments, RysannMD achieved the best median F1 measure across the

  12. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools.

    Directory of Open Access Journals (Sweden)

    Amy Franciscovich

    Full Text Available Biliary atresia (BA is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone's camera and color recognition software to analyze an infant's stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 and wrapped to work on iOS and Android platforms. In order to define the gold standard regarding stool color, seven pediatricians were asked to review 45 photographs of infant stool and rate them as acholic, normal, or indeterminate. Samples for which 6+ pediatricians demonstrated agreement defined the gold standard, and only these samples were included in the analysis. Accuracy of PoopMD was assessed using an iPhone 5s with incandescent lighting. Variability in analysis of stool photographs as acholic versus normal with intermediate rating weighted as 50% agreement (kappa was compared between three laypeople and one expert user. Variability in output was also assessed between an iPhone 5s and a Samsung Galaxy S4, as well as between incandescent lighting and compact fluorescent lighting. Six-plus pediatricians agreed on 27 normal and 7 acholic photographs; no photographs were defined as indeterminate. The sensitivity was 7/7 (100%. The specificity was 24/27 (89% with 3/27 labeled as indeterminate; no photos of normal stool were labeled as acholic. The Laplace-smoothed positive likelihood ratio was 6.44 (95% CI 2.52 to 16.48 and the negative likelihood ratio was 0.13 (95% CI 0.02 to 0.83. kappauser was 0.68, kappaphone was 0.88, and kappalight was 0.81. Therefore, in this pilot study, PoopMD accurately differentiates acholic from normal color with substantial agreement across users, and almost perfect agreement across two popular smartphones and ambient light

  13. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools.

    Science.gov (United States)

    Franciscovich, Amy; Vaidya, Dhananjay; Doyle, Joe; Bolinger, Josh; Capdevila, Montserrat; Rice, Marcus; Hancock, Leslie; Mahr, Tanya; Mogul, Douglas B

    2015-01-01

    Biliary atresia (BA) is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone's camera and color recognition software to analyze an infant's stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 and wrapped to work on iOS and Android platforms. In order to define the gold standard regarding stool color, seven pediatricians were asked to review 45 photographs of infant stool and rate them as acholic, normal, or indeterminate. Samples for which 6+ pediatricians demonstrated agreement defined the gold standard, and only these samples were included in the analysis. Accuracy of PoopMD was assessed using an iPhone 5s with incandescent lighting. Variability in analysis of stool photographs as acholic versus normal with intermediate rating weighted as 50% agreement (kappa) was compared between three laypeople and one expert user. Variability in output was also assessed between an iPhone 5s and a Samsung Galaxy S4, as well as between incandescent lighting and compact fluorescent lighting. Six-plus pediatricians agreed on 27 normal and 7 acholic photographs; no photographs were defined as indeterminate. The sensitivity was 7/7 (100%). The specificity was 24/27 (89%) with 3/27 labeled as indeterminate; no photos of normal stool were labeled as acholic. The Laplace-smoothed positive likelihood ratio was 6.44 (95% CI 2.52 to 16.48) and the negative likelihood ratio was 0.13 (95% CI 0.02 to 0.83). kappauser was 0.68, kappaphone was 0.88, and kappalight was 0.81. Therefore, in this pilot study, PoopMD accurately differentiates acholic from normal color with substantial agreement across users, and almost perfect agreement across two popular smartphones and ambient light settings. PoopMD

  14. Species-specific activation of TLR4 by hypoacylated endotoxins governed by residues 82 and 122 of MD-2.

    Science.gov (United States)

    Oblak, Alja; Jerala, Roman

    2014-01-01

    The Toll-like receptor 4/MD-2 receptor complex recognizes endotoxin, a Gram-negative bacterial cell envelope component. Recognition of the most potent hexaacylated form of endotoxin is mediated by the sixth acyl chain that protrudes from the MD-2 hydrophobic pocket and bridges TLR4/MD-2 to the neighboring TLR4 ectodomain, driving receptor dimerization via hydrophobic interactions. In hypoacylated endotoxins all acyl chains could be accommodated within the binding pocket of the human hMD-2. Nevertheless, tetra- and pentaacylated endotoxins activate the TLR4/MD-2 receptor of several species. We observed that amino acid residues 82 and 122, located at the entrance to the endotoxin binding site of MD-2, have major influence on the species-specific endotoxin recognition. We show that substitution of hMD-2 residue V82 with an amino acid residue with a bulkier hydrophobic side chain enables activation of TLR4/MD-2 by pentaacylated and tetraacylated endotoxins. Interaction of the lipid A phosphate group with the amino acid residue 122 of MD-2 facilitates the appropriate positioning of the hypoacylated endotoxin. Moreover, mouse TLR4 contributes to the agonistic effect of pentaacylated msbB endotoxin. We propose a molecular model that explains how the molecular differences between the murine or equine MD-2, which both have sufficiently large hydrophobic pockets to accommodate all five or four acyl chains, influence the positioning of endotoxin so that one of the acyl chains remains outside the pocket and enables hydrophobic interactions with TLR4, leading to receptor activation.

  15. Adding Theoretical Grounding to Grounded Theory: Toward Multi-Grounded Theory

    OpenAIRE

    Göran Goldkuhl; Stefan Cronholm

    2010-01-01

    The purpose of this paper is to challenge some of the cornerstones of the grounded theory approach and propose an extended and alternative approach for data analysis and theory development, which the authors call multi-grounded theory (MGT). A multi-grounded theory is not only empirically grounded; it is also grounded in other ways. Three different grounding processes are acknowledged: theoretical, empirical, and internal grounding. The authors go beyond the pure inductivist approach in GT an...

  16. 76 FR 50771 - Submission for Review: RI 25-37, Evidence To Prove Dependency of a Child, 3206-0206

    Science.gov (United States)

    2011-08-16

    ... MANAGEMENT Submission for Review: RI 25-37, Evidence To Prove Dependency of a Child, 3206-0206 AGENCY: U.S... Dependency of a Child. As required by the Paperwork Reduction Act of 1995 (Pub. L. 104-13, 44 U.S.C. chapter.... SUPPLEMENTARY INFORMATION: Evidence to Prove Dependency of a Child is designed to collect sufficient information...

  17. First ATRF Chili Contest Proves It’s Not Always about the Meat | Poster

    Science.gov (United States)

    Wafting cumin through the building, 15 slow cookers full of chili lined an L-shaped conference room at the Frederick National Laboratory for Cancer Research Advanced Technology Research Facility (ATRF), as voters strolled past “No electioneering” signs and the tasting began Feb. 29. Chili No. 13 came out of the gate with a spicy authority. “My tongue’s still tingling,” said one taster. “Just looking at it, you can tell how spicy it is,” said another judge. Thick with ground beef, with a smoky, peppery aroma, it was layered with black beans and corn, and it had a back-of-the-throat burn no other contestant’s offering could match. A nearby box of tissues served as a must-have for anyone sampling the sinus-clearing concoction.

  18. Outperforming whom? A multilevel study of performance-prove goal orientation, performance, and the moderating role of shared team identification.

    Science.gov (United States)

    Dietz, Bart; van Knippenberg, Daan; Hirst, Giles; Restubog, Simon Lloyd D

    2015-11-01

    Performance-prove goal orientation affects performance because it drives people to try to outperform others. A proper understanding of the performance-motivating potential of performance-prove goal orientation requires, however, that we consider the question of whom people desire to outperform. In a multilevel analysis of this issue, we propose that the shared team identification of a team plays an important moderating role here, directing the performance-motivating influence of performance-prove goal orientation to either the team level or the individual level of performance. A multilevel study of salespeople nested in teams supports this proposition, showing that performance-prove goal orientation motivates team performance more with higher shared team identification, whereas performance-prove goal orientation motivates individual performance more with lower shared team identification. Establishing the robustness of these findings, a second study replicates them with individual and team performance in an educational context. (c) 2015 APA, all rights reserved).

  19. A virtual observatory for photoionized nebulae: the Mexican Million Models database (3MdB).

    Science.gov (United States)

    Morisset, C.; Delgado-Inglada, G.; Flores-Fajardo, N.

    2015-04-01

    Photoionization models obtained with numerical codes are widely used to study the physics of the interstellar medium (planetary nebulae, HII regions, etc). Grids of models are performed to understand the effects of the different parameters used to describe the regions on the observables (mainly emission line intensities). Most of the time, only a small part of the computed results of such grids are published, and they are sometimes hard to obtain in a user-friendly format. We present here the Mexican Million Models dataBase (3MdB), an effort to resolve both of these issues in the form of a database of photoionization models, easily accessible through the MySQL protocol, and containing a lot of useful outputs from the models, such as the intensities of 178 emission lines, the ionic fractions of all the ions, etc. Some examples of the use of the 3MdB are also presented.

  20. MD1831: Single Bunch Instabilities with Q" and Non-Linear Corrections

    CERN Document Server

    Carver, Lee Robert; De Maria, Riccardo; Li, Kevin Shing Bruce; Amorim, David; Biancacci, Nicolo; Buffat, Xavier; Maclean, Ewen Hamish; Metral, Elias; Lasocha, Kacper; Lefevre, Thibaut; Levens, Tom; Salvant, Benoit; CERN. Geneva. ATS Department

    2017-01-01

    During MD1751, it was observed that both a full single beam and 964 non-colliding bunches in Beam 1 (B1) and Beam 2 (B2) were both stable at the End of Squeeze (EOS) for 0A in the Landau Octupoles. At ß* = 40cm there is also a significant Q" arising from the lattice, as well as uncorrected non-linearities in the Insertion Regions (IRs). Each of these effects could be capable of fully stabilising the beam. This MD made first use of a Q" knob through variation of the Main Sextupoles (MS) by stabilising a single bunch at Flat Top, before showing at EOS that the non-linearities were the main contributors to the beam stability.

  1. LHC MD 652: Coupled-Bunch Instability with Smaller Emittance (all HOMs)

    CERN Document Server

    AUTHOR|(CDS)2081238; Timko, Helga; CERN. Geneva. ATS Department

    2017-01-01

    The aim of the MD was to measure the coupled-bunch stability from all HOM impedances, with a reduced longitudinal emittance in order to explore the HL-LHC conditions. The acceleration ramp was performed with the nominal beams of 2016, but a reduced target bunch length and RF voltage. With this reduced emittance, the beam remained close but above the single-bunch stability threshold. No coupled-bunch oscillations were observed, so we can conclude that the stability threshold for coupled-bunch instability is not lower than the single-bunch threshold. An interesting observation in the MD was the long-lasting injection oscillations, whose traces can still be seen at arrival to flat top; in agreement with observations in earlier MDs. The measurements took place between 28th October 20:00 and 29th October 05:10.

  2. MD-CTS: An integrated terminology reference of clinical and translational medicine

    Directory of Open Access Journals (Sweden)

    Will Ray

    2016-01-01

    Full Text Available New vocabularies are rapidly evolving in the literature relative to the practice of clinical medicine and translational research. To provide integrated access to new terms, we developed a mobile and desktop online reference—Marshfield Dictionary of Clinical and Translational Science (MD-CTS. It is the first public resource that comprehensively integrates Wiktionary (word definition, BioPortal (ontology, Wiki (image reference, and Medline abstract (word usage information. MD-CTS is accessible at http://spellchecker.mfldclin.edu/. The website provides a broadened capacity for the wider clinical and translational science community to keep pace with newly emerging scientific vocabulary. An initial evaluation using 63 randomly selected biomedical words suggests that online references generally provided better coverage (73%-95% than paper-based dictionaries (57–71%.

  3. Discovering and Developing Successful Cardiovascular Therapeutics: A Conversation With James N. Topper, MD, PhD.

    Science.gov (United States)

    Topper, James N; Rutherford, John D

    2016-11-15

    Dr James (also known as Jamie) N. Topper, MD, PhD, serves as Managing General Partner at Frazier Healthcare Partners, where he leads the Life Science Venture practice. In 2011, and 2016, he was named to the Midas List of leading venture capitalists, and, in 2013, he was recognized by Forbes as one of the top 10 healthcare investors. He has >25 years of experience working with entrepreneurs to found and build successful therapeutics-focused companies. Dr Topper holds a BS from the University of Michigan. He received an MD and PhD (in biophysics) from Stanford University School of Medicine. He completed postgraduate training in internal medicine and cardiovascular disease at the Brigham and Women's Hospital in Boston and is board certified in both disciplines. © 2016 American Heart Association, Inc.

  4. Towards the Structural Characterization of Intrinsically Disordered Proteins by SAXS and MD Simulation

    Science.gov (United States)

    Oroguchi, Tomotaka; Ikeguchi, Mitsunori; Sato, Mamoru

    2011-01-01

    Dynamical structures of intrinsically disordered proteins (IDPs) and multi-domain proteins that include large ID regions between the domains are unable to be determined by such conventional methods as X-ray crystallography and electron microscopy. Small-angle X-ray scattering (SAXS) is suitable to determine low-resolution structures of proteins and protein complexes in solution, but the structural data on protein dynamics are averaged over the structural ensemble in protein solution. To overcome this problem, we have developed a novel method, named MD-SAXS, of the combined use of SAXS and molecular dynamics (MD) simulation to analyze protein dynamics in solution of multi-subunit protein complexes and multi-domain proteins toward the structural characterization of IDPs. Here we show validity of the method through the structural characterization of restriction Endonuclease EcoO109I.

  5. Grounding, shielding, and bonding

    Science.gov (United States)

    Catrysse, J.

    1991-06-01

    In the electromagnetic compatibility design (EMC) of systems and circuits, both grounding and shielding are related to the coupling mechanisms of the system with (radiated) electromagnetic fields. Grounding is more related to the source or victim circuit (or system) and determines the characteristic of the coupling mechanism between fields and currents/voltages. Shielding is a way of interacting in the radiation path of an electromagnetic field. The basic principles and practical design rules are discussed.

  6. Molecular Dynamics (MD) Simulation of DNA Dodecamer with 5-hydroxy-6-cytosinyl Radical

    OpenAIRE

    M, Pinak; H., YAMAGUCHI; R., OSMAN; Space and Particle Radiation Science Research Group, National Institute of Radiological Sciences: Comenius University; Space and Particle Radiation Science Research Group, National Institute of Radiological Sciences; Dept of Physiology and Biophysics, Mount Sinai School of Medicine, The City University of New York

    1996-01-01

    Molecular dynamics (MD) simulation of DNA dodecamer d (CGCGAATTTC^GCG)2 with a primary radiation damage represented by 5-hydroxy-6-cytosinyl radical (C^) in position 9 was performed with AMBER 4.0 force field with periodic boundary conditions for the solvent. The temperature, potential energy of the system, energetic contributions from groups and RMS deviation from original positions were examined throughout the course of the simulation up to 140 ps. The stabilized structure (after 100 ps) wa...

  7. β∗ levelling using the LHC Lumi Server (MD 2427)

    CERN Document Server

    Hostettler, Michi; Fuchsberger, Kajetan; Gabriel, Mathieu; Hemelsoet, Georges-Henry; Hruska, Marek; Jacquet, Delphine; Wenninger, Jorg; CERN. Geneva. ATS Department

    2018-01-01

    Luminosity levelling by β∗ is the baseline scenario for HL-LHC and will possibly be used in 2018 LHC operation. In this MD, we commissioned a novel controls approach to β∗ levelling using improved LSA trims and automatic orchestration. Compared to the regular squeeze using sequences, this approach is aimed to be minimally invasive to LHC operation in Stable Beams. Using this tool, we demonstrated the feasibility of β∗ levelling between 1 m and 30 cm.

  8. Learning from a leader: an interview with Dirk M. Elston, MD.

    Science.gov (United States)

    Elston, Dirk M; Bronfenbrener, Roman

    2014-02-01

    As residents, we all owe at least some of our knowledge base to the teachings of Dirk M. Elston, MD. I recently sat down with Dr. Elston to find out who the man is behind the work. Our discussion was both a humbling and enlightening experience for me. This interview serves to illustrate the human side of a current pioneer within our field and also to inspire our generation of emerging leaders.

  9. William Healy, M.D., Father of the American Child Guidance Movement

    Science.gov (United States)

    1981-08-01

    the University of Maryland in partial fulfillment of the requirements for the degree of Master of Arts 1981 u...Wil iam iiealy, M.D. Di t ribut iorn/ Father of the American .. Child Guidance Movement Avatlabliitv Codes Dizt Grant Huls,’ Wagner, Mastei of Art -,, 1...coming book, "The Science of Psychoanalysis " (1928). Healy was chosen president of this organization in 1926.104 Healy used his membership in national

  10. Modeling and imaging land-cover influences on air-temperature in and near Baltimore, MD

    Science.gov (United States)

    Gordon Heisler; Alexis Ellis; David J. Nowak; Ian. Yesilonis

    2015-01-01

    Over the course of 1681 hours between May 5 and September 30, 2006, air temperatures measured at the 1.5-m height at seven sites in and near the city of Baltimore, MD were used to empirically model Δ Tˆ R-p , the difference in air temperature between a site in downtown Baltimore and the six other sites. Variables in the...

  11. Measurements of $\\Delta m_d$, $\\Delta m_s$, and $\\sin 2 \\beta$ with LHCb

    CERN Document Server

    Wishahi, Julian

    2012-01-01

    We present measurements of the oscillation frequencies $\\Delta m_d$ and $\\Delta m_s$ of $B$ meson mixing as well as a measurement of the time-dependent CP-asymmetry in decays of $B^0\\to J/\\psi K_{\\text{S}}^0$ based on $1.0\\,\\text{fb}^{-1}$ of data collected by the LHCb experiment in 2011. These measurements give valuable input to tests of the unitarity of the Cabibbo-Kobayashi-Maskawa matrix.

  12. Richard Mollica, Md, Mar. Texto de salud mental global: trauma y recuperación

    OpenAIRE

    Alberto Perales-Cabrera

    2014-01-01

    This is to communicate on the book by Richard Mollica. Md, sea. Text Global Mental Health: Trauma and Recovery. Guidelines for clinical care and field trauma victims worldwide (Textbook of global mental health. Trauma and recovery A companion guide for field and clinical care of traumatized people worldwide). Edited by Harvard Refugee Trauma Program, USA, 2011m electronic version can be obtained for $ 60.00 with: http: // mollica/ www.lulu.com/shop/richard-f-textbook-of-global-mind-healthtrau...

  13. Report from LHC MD 1399: Effect of linear coupling on nonlinear observables in the LHC.

    CERN Document Server

    Maclean, Ewen Hamish; Giovannozzi, Massimo; Persson, Tobias Hakan Bjorn; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2017-01-01

    Simulation work during Run 1 established that linear coupling had a large impact on nonlinear observables such as detuning with amplitude and dynamic aperture. Linear coupling is generally taken to be the largest single source of uncertainty in the modelling of the LHC’s nonlinear single particle dynamics. ThisMD sought to verify that such behaviour, to this point only observed in simulation, translated into the real machine.

  14. Queueing systems with constant service time and evaluation of M/D/1,k

    DEFF Research Database (Denmark)

    Iversen, Villy Bæk

    1997-01-01

    Systems with constant service times have the particular property that the customers leave the servers in the same order in which they areaccepted for service. Probabilitites of integral waiting times can be expressed by the state probabilities, and non-integral waiting timescan be expressed by in...... by integral waiting times. This in combination by a result by Keilson results in an effective algorithm for evaluating M/D/1,k....

  15. 78 FR 47412 - Tyson D. Quy, M.D.; Decision and Order

    Science.gov (United States)

    2013-08-05

    ....S., 74 FR 36,751, 36,755 (DEA 2009); Martha Hernandez, M.D., 62 FR 61,145, 61,147 (DEA 1997). In... determination. Mark De La Lama, P.A., 76 FR 20,011, 20,018 (DEA 2011). 2. Factors Two and Four: Applicant's... prior to this arrest, I find that this incident is relevant to factor three. But see Mark De La Lama, P...

  16. IncMD: incremental trie-based structural motif discovery algorithm.

    Science.gov (United States)

    Badr, Ghada; Al-Turaiki, Isra; Turcotte, Marcel; Mathkour, Hassan

    2014-10-01

    The discovery of common RNA secondary structure motifs is an important problem in bioinformatics. The presence of such motifs is usually associated with key biological functions. However, the identification of structural motifs is far from easy. Unlike motifs in sequences, which have conserved bases, structural motifs have common structure arrangements even if the underlying sequences are different. Over the past few years, hundreds of algorithms have been published for the discovery of sequential motifs, while less work has been done for the structural motifs case. Current structural motif discovery algorithms are limited in terms of accuracy and scalability. In this paper, we present an incremental and scalable algorithm for discovering RNA secondary structure motifs, namely IncMD. We consider the structural motif discovery as a frequent pattern mining problem and tackle it using a modified a priori algorithm. IncMD uses data structures, trie-based linked lists of prefixes (LLP), to accelerate the search and retrieval of patterns, support counting, and candidate generation. We modify the candidate generation step in order to adapt it to the RNA secondary structure representation. IncMD constructs the frequent patterns incrementally from RNA secondary structure basic elements, using nesting and joining operations. The notion of a motif group is introduced in order to simulate an alignment of motifs that only differ in the number of unpaired bases. In addition, we use a cluster beam approach to select motifs that will survive to the next iterations of the search. Results indicate that IncMD can perform better than some of the available structural motif discovery algorithms in terms of sensitivity (Sn), positive predictive value (PPV), and specificity (Sp). The empirical results also show that the algorithm is scalable and runs faster than all of the compared algorithms.

  17. An Efficient Hybrid DSMC/MD Algorithm for Accurate Modeling of Micro Gas Flows

    KAUST Repository

    Liang, Tengfei

    2013-01-01

    Aiming at simulating micro gas flows with accurate boundary conditions, an efficient hybrid algorithmis developed by combining themolecular dynamics (MD) method with the direct simulationMonte Carlo (DSMC)method. The efficiency comes from the fact that theMD method is applied only within the gas-wall interaction layer, characterized by the cut-off distance of the gas-solid interaction potential, to resolve accurately the gas-wall interaction process, while the DSMC method is employed in the remaining portion of the flow field to efficiently simulate rarefied gas transport outside the gas-wall interaction layer. A unique feature about the present scheme is that the coupling between the two methods is realized by matching the molecular velocity distribution function at the DSMC/MD interface, hence there is no need for one-toone mapping between a MD gas molecule and a DSMC simulation particle. Further improvement in efficiency is achieved by taking advantage of gas rarefaction inside the gas-wall interaction layer and by employing the "smart-wall model" proposed by Barisik et al. The developed hybrid algorithm is validated on two classical benchmarks namely 1-D Fourier thermal problem and Couette shear flow problem. Both the accuracy and efficiency of the hybrid algorithm are discussed. As an application, the hybrid algorithm is employed to simulate thermal transpiration coefficient in the free-molecule regime for a system with atomically smooth surface. Result is utilized to validate the coefficients calculated from the pure DSMC simulation with Maxwell and Cercignani-Lampis gas-wall interaction models. ©c 2014 Global-Science Press.

  18. The Cannabis sativa Versus Cannabis indica Debate: An Interview with Ethan Russo, MD

    OpenAIRE

    Piomelli, Daniele; Russo, Ethan B.

    2016-01-01

    Dr. Ethan Russo, MD, is a board-certified neurologist, psychopharmacology researcher, and Medical Director of PHYTECS, a biotechnology company researching and developing innovative approaches targeting the human endocannabinoid system. Previously, from 2003 to 2014, he served as Senior Medical Advisor and study physician to GW Pharmaceuticals for three Phase III clinical trials of Sativex? for alleviation of cancer pain unresponsive to optimized opioid treatment and studies of Epidiolex? for ...

  19. A Tool Use Task Proves Enriching for a Captive Sea Otter (Enhydra lutris

    Directory of Open Access Journals (Sweden)

    Pepper R. Hanna

    2016-05-01

    Full Text Available Environmental enrichment is used to improve an animal’s physical and psychological well-being while housed in a captive environment. Alligood and Leighty (2015 suggested that enrichment that emulates the natural and preferred behaviors of the species may be optimal for improving welfare. Cognitive tasks that mirror challenges in an animal’s natural environment may prove especially beneficial (Washburn, 2015. The present study was designed to determine whether two sea otters (Enhydra lutis, Emma and Buck, were capable of learning to use a novel tool in a novel context. The otters’ time spent engaged with the apparatus was also examined to determine if such a task would be enriching to these animals. Although the sea otters were not successful in solving the tool use task, interaction with the apparatus appeared enriching to Emma. She spent on average 55.4% of each trial at the apparatus, whereas Buck spent only 6.2%. Only Emma’s interaction with the apparatus suggests that this device was very interesting and consequently enriching for her. Cognitive challenges, then, may be enriching even when animals fail to solve the intended problem.

  20. A Mechanically Proved and an Incremental Development of the Session Initiation Protocol INVITE Transaction

    Directory of Open Access Journals (Sweden)

    Rajaa Filali

    2014-01-01

    Full Text Available The Session Initiation Protocol (SIP is an application layer signaling protocol used to create, manage, and terminate sessions in an IP based network. SIP is considered as a transactional protocol. There are two main SIP transactions, the INVITE transaction and the non-INVITE transaction. The SIP INVITE transaction specification is described in an informal way in Request for Comments (RFC 3261 and modified in RFC 6026. In this paper we focus on the INVITE transaction of SIP, over reliable and unreliable transport mediums, which is used to initiate a session. In order to ensure the correctness of SIP, the INVITE transaction is modeled and verified using event-B method and its Rodin platform. The Event-B refinement concept allows an incremental development by defining the studied system at different levels of abstraction, and Rodin discharges almost all proof obligations at each level. This interaction between modeling and proving reduces the complexity and helps in assuring that the INVITE transaction SIP specification is correct, unambiguous, and easy to understand.

  1. Atrial overdriving is beneficial in patients with atrial arrhythmias: first results of the PROVE Study.

    Science.gov (United States)

    Funck, R C; Adamec, R; Lurje, L; Capucci, A; Ritter, P; Shekan, D; Slegers, L C; Tavernier, R; Ishikawa, T

    2000-11-01

    The AF Prevention by Overdriving (PROVE) trial is an ongoing prospective study of the effectiveness of atrial overdrive pacing combined with an Automatic Rest Rate function in the prevention of atrial arrhythmias. All patients who have received a Talent DR 213 pacemaker are eligible for enrollment into the study. After a 1-month monitoring period, the patients are divided into two groups. Group I includes patients with > or = 2 appropriate mode-switch (MS) episodes, or 1 MS episode of > or = 10 minutes, and/or > 300 atrial runs of > 5 beats/month. Group II includes all other patients. The number and duration of atrial arrhythmias are measured the pacemaker's Automatic Interpretation and Data Analysis software (AIDA). Patients' quality-of-life is measured by a validated functional status questionnaire. After having been grouped, the patients are randomly assigned, in a crossover design, to standard DDDR or overdrive pacing + Rest Rate, each programmed for a 3-month period. Preliminary results in 78 patients show a 34% reduction in the mean number of MS, and a mean 48% shortening of the overall duration of the episodes by overdrive pacing + Rest Rate, achieved by a mean 84% prevalence of atrial pacing. Overdrive pacing + Rest Rate was well tolerated and associated with a slight improvement in quality-of-life.

  2. The written mathematical communication profile of prospective math teacher in mathematical proving

    Science.gov (United States)

    Pantaleon, K. V.; Juniati, D.; Lukito, A.; Mandur, K.

    2018-01-01

    Written mathematical communication is the process of expressing mathematical ideas and understanding in writing. It is one of the important aspects that must be mastered by the prospective math teacher as tool of knowledge transfer. This research was a qualitative research that aimed to describe the mathematical communication profile of the prospective mathematics teacher in mathematical proving. This research involved 48 students of Mathematics Education Study Program; one of them with moderate math skills was chosen as the main subject. Data were collected through tests, assignments, and task-based interviews. The results of this study point out that in the proof of geometry, the subject explains what is understood, presents the idea in the form of drawing and symbols, and explains the content/meaning of a representation accurately and clearly, but the subject can not convey the argument systematically and logically. Whereas in the proof of algebra, the subject describes what is understood, explains the method used, and describes the content/meaning of a symbolic representation accurately, systematically, logically, but the argument presented is not clear because it is insufficient detailed and complete.

  3. Search for diagnostic proteins to prove authenticity of organic wheat grains (Triticum aestivum L.).

    Science.gov (United States)

    Zörb, Christian; Betsche, Thomas; Langenkämper, Georg

    2009-04-08

    Research comparing the biochemical composition of wheat grains from organic or conventional agriculture has used the targeted analytical approach. To obtain a more comprehensive record of the food's composition, we employed protein profiling techniques. Levels of 1049 proteins were recorded in wheat grains (Triticum aestivum L., cv. Titlis) of two growing seasons from a rigorously controlled field trial in Switzerland, containing organic and conventional plots. Levels of 25 proteins were different between organic and conventional wheat in both years. Storage proteins, enzymes of carbohydrate metabolism, a peroxidase, and proteins of unknown function were affected by the agricultural regime. Total protein content was lower in organic wheat. We consider these differences negligible with regard to nutrition in an average diet and propose that food quality of conventional and organic wheat grown in the field trial was equal. Applying various filters and calculations, one of which takes seasonal influences into account, 16 of the 25 proteins with different levels in organic and conventional wheat were retained. These 16 "diagnostic" proteins have the potential to afford a signature to prove authenticity of organic wheat.

  4. Ultrasonic Assessment of Females with Carpal Tunnel Syndrome Proved by Nerve Conduction Study

    Directory of Open Access Journals (Sweden)

    Ihsan M. Ajeena

    2013-01-01

    Full Text Available Introduction. Carpal tunnel syndrome (CTS is the most commonly diagnosed entrapment neuropathy of the upper extremity. The objective of this study was to diagnose CTS and to assess its severity using high resolution ultrasound (HRUS depending on the results of nerve conduction study (NCS. Methods. A prospective cross-sectional study, in which HRUS was performed at 63 wrists of 35 female patients with different severity of CTS (as proved by NCS. Furthermore, 40 healthy volunteers (80 wrists underwent the same tests as the patients and have been chosen to match the patients in gender, age, and body mass index (BMI. The cross section area (CSA of the median nerve (MN was obtained using HRUS at the carpal tunnel inlet by direct tracing method. Results. There was a significant difference in the CSA of the MN at the tunnel inlet in CTS patients when compared with the control group. In fact, the CSA of the control group showed a significant difference from each of patients subgroups. Furthermore, a significant difference in the CSA was seen in between these subgroups. In conclusion, the US examination of the MN seems to be a promising method in diagnosing and grading of carpal tunnel syndrome.

  5. Prefixation Ability Index and Verbal Grammar Correlation Index prove the reality of Buyeo group

    Directory of Open Access Journals (Sweden)

    Alexander AKULOV

    2016-06-01

    Full Text Available All suggestions about reality of Buyeo group were based on the representation of a language as a heap of lexemes: such method allows different scholars to make different conclusions and doesn't suppose verification. Language is first of all structure/grammar, but not a heap of lexemes, so methods of comparative linguistics should be based on comparison of grammars. Prefixation Ability Index (PAI and Verbal Grammar Correlation Index (VGCI are typology based tools of comparative linguistics. PAI allows us to see whether languages are potentially related: if values of PAI differ more than fourfold, it's a sign of unrelatedness, if PAI values differ less than fourfold, there is a possibility for some further search to find proves of relatedness. VGCI completely answers questions about relatedness/unrelatedness: if VGCI value is 0.4 and more then languages are related, if VGCI is 0.3 and less then  languages are unrelated. PAI of Japanese is 0.13, PAI of Korean is 0.13; it means they can be related. VGCI of Japanese and Korean is 0.57, it's almost the same as VGCI of English and Afrikaans that is 0.56, so it means that Japanese and Korean belong to the same group, but not just to the same family.

  6. Comparison of fission modes in 252Cf, 257Fm, and 260Md

    Science.gov (United States)

    van Aarle, J.; Siemon, K.; Wild, J. F.; Lougheed, R. W.; Westmeier, W.; Patzelt, P.

    1998-10-01

    Although the spontaneous-fission properties of heavy actinides have been studied for well over 35 years, many interesting and informative details continue to come into light. During the last decade, the spontaneous fission of 252Cf, 257Fm and 260Md has been extensively investigated at the Philipps University of Marburg (1-4), by means of a gadolinium-doped liquid scintillation tank for neutron counting and surface barrier detectors for fission fragment detection. The three nuclides represent the transition from the well-known asymmetric fission yield distribution, as it is characteristic for 252Cf, to a much more symmetrical one, found in the fission of 260Md. Therefore, trends in the dynamical changes of fission properties have been derived from these studies. For the spontaneous fission of 252Cf and 260Md, it was already shown that different fission modes, as proposed by theoretical calculations of Brosa et al. (5), could be separated, using the correlation between the neutrons emitted in a fission event and both the observed fission-fragment mass and the total kinetic energy (1, 2). In the case of 257Fm, no theoretical calculations for fission modes exist. However, from the fission properties of the two surrounding actinides, one can expect at least three different fission modes, namely two "standard" and the "supershort" mode. In this paper, results from the recent 257Fm experiment will be presented and compared to systematics extracted from the fission properties of other heavy actinides.

  7. MD-portal Materials Database: Effective Materials Property Information Management in Nuclear Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Gyeonggeun; Kil, Soyeon; Kwon, Junhyun [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    The collective properties of the nuclear materials are defined as standard industrial codes such as ASME codes. While in service, the materials are aged and degraded, and the initial properties are changed according to the operating environments. These changes are a matter of substantial concern of the operators, regulators, and researchers in nuclear fields. Hence, the material property database considering the degradation is required, and the successful management and use of material property information must be responsive to the continuing changes and increasing complexity in nuclear engineering materials. Recently, the nuclear materials division in the Korea Atomic Energy Research Institute (KAERI) launched a comprehensive portal website for nuclear material information, which is known as the MD-portal. The MD-portal contains various technical documents on the degradation and development of nuclear materials. Additionally, the nuclear materials database (MatDB) is incorporated in it. The MatDB covers the mechanical properties of various nuclear structural materials used as the components: a reactor pressure vessel, steam generator, and primary and secondary piping. In this study, we introduced the MD-portal MatDB briefly, and showed an application of the MatDB to the real case of material degradations in NPPs.

  8. Mimicking titration experiments with MD simulations: A protocol for the investigation of pH-dependent effects on proteins

    Science.gov (United States)

    Socher, Eileen; Sticht, Heinrich

    2016-03-01

    Protein structure and function are highly dependent on the environmental pH. However, the temporal or spatial resolution of experimental approaches hampers direct observation of pH-induced conformational changes at the atomic level. Molecular dynamics (MD) simulation strategies (e.g. constant pH MD) have been developed to bridge this gap. However, one frequent problem is the sampling of unrealistic conformations, which may also lead to poor pKa predictions. To address this problem, we have developed and benchmarked the pH-titration MD (pHtMD) approach, which is inspired by wet-lab titration experiments. We give several examples how the pHtMD protocol can be applied for pKa calculation including peptide systems, Staphylococcus nuclease (SNase), and the chaperone HdeA. For HdeA, pHtMD is also capable of monitoring pH-dependent dimer dissociation in accordance with experiments. We conclude that pHtMD represents a versatile tool for pKa value calculation and simulation of pH-dependent effects in proteins.

  9. Hybrid Pressure Retarded Osmosis−Membrane Distillation (PRO−MD) Process for Osmotic Power and Clean Water Generation

    KAUST Repository

    Han, Gang

    2015-05-20

    A novel pressure retarded osmosis−membrane distillation (PRO−MD) hybrid process has been experimentally conceived for sustainable production of renewable osmotic power and clean water from various waters. The proposed PRO−MD system may possess unique advantages of high water recovery rate, huge osmotic power generation, well controlled membrane fouling, and minimal environmental impacts. Experimental results show that the PRO−MD hybrid process is promising that not only can harvest osmotic energy from freshwater but also from wastewater. When employing a 2 M NaCl MD concentrate as the draw solution, ultrahigh power densities of 31.0 W/m2 and 9.3 W/m2 have been demonstrated by the PRO subsystem using deionized water and real wastewater brine as the feeds, respectively. Simultaneously, high purity potable water with a flux of 32.5−63.1 L/(m2.h) can be produced by the MD subsystem at 40−60 °C without any detrimental effects of fouling. The energy consumption in the MD subsystem might be further reduced by applying a heat exchanger in the hybrid system and using low-grade heat or solar energy to heat up the feed solution. The newly developed PRO−MD hybrid process would provide insightful guidelines for the exploration of alternative green technologies for renewable osmotic energy and clean water production.

  10. Research of Pre-Service Elementary Mathematics Teachers’ Beliefs in Proof, Proving Processes and Proof Evaluation Processes

    Directory of Open Access Journals (Sweden)

    Candaş Uygan

    2014-08-01

    Full Text Available The purpose of this study is to research pre-service elementary mathematics teachers’ beliefs on meaning and features of mathematical proof, their proving processes and their reasoning process while evaluating validities of proof examples. This study is a qualitative research. Participants of the study are three pre-service elementary mathematics teachers who continue to study in a state university from Central Anatolia Region. Participants’ beliefs on proof were researched with semi-structured interview whilst proving processes and evaluation processes of proof examples were researched with clinical interviews. Interviews were recorded with video camera and data were analyzed according to qualitative methods. When beliefs on proof were analyzed, it was indicated that participants see mathematical proofs as problem solving process and exploration of source of mathematical knowledge, and believe that proofs have to be deductive, apprehensible and have to include generalizable results. Also according to opinions of all three participants, they believe that their proving abilities are insufficient. Analyze results related to proving processes indicated that pre-service teachers considered conclusions of theorems as if they are conditions of theorems and also used proving strategies uncomprehendingly in proving process. Finally, analyze results related to proof evaluation process indicated that participants assessed computer based experimental verifications as valid mathematical proofs and had mistakes when they evaluated warrants used in verifications that break axiomatical structure of proofs.Key Words:    Beliefs in the context of proof, proving, proof evaluation, teacher education

  11. Ground Enterprise Management System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Emergent Space Technologies Inc. proposes to develop the Ground Enterprise Management System (GEMS) for spacecraft ground systems. GEMS will provide situational...

  12. Benefit of Intensive Statin Therapy in Women: Results from PROVE IT-TIMI 22

    Science.gov (United States)

    Truong, Quynh A.; Murphy, Sabina A; McCabe, Carolyn H.; Armani, Annemarie; Cannon, Christopher P.

    2011-01-01

    Background Despite the known benefit of intensive statin therapy for reducing future cardiovascular events, its effectiveness in women has been questioned by some. Methods and Results In the Pravastatin or Atorvastatin Evaluation and Infection Therapy–Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) trial, 911 (21.9%) women and 3251 (78.1%) men were randomized to intensive statin (atorvastatin 80 mg) versus standard therapy (pravastatin 40 mg) for a median duration of 2.1 years. The primary endpoint was death, myocardial infarction (MI), unstable angina (UA), revascularization (occurring after 30 days) or stroke. Safety endpoints included elevations in liver function tests, creatine kinase and myalgias/myositis. Women had a reduction in LDL of 42.8% from baseline at 30 days (to a median of 60 mg/dL) in the intensive therapy arm with 88.8% reaching LDL goal of <100 mg/dL and 65.0% with <70 mg/dL as compared with a 16.8% reduction in LDL (to a median of 88 mg/dL) in the standard therapy. Women on intensive statin therapy had a significant 25% relative reduction over standard-dose (hazard ratio [HR] 0.75; 95% confidence interval [CI] 0.57-0.99; p=0.04) for primary composite endpoint, compared with a 14% reduction for men (HR 0.86; 95% CI 0.75-0.99; p=0.04), p-interaction=0.38. No differences were observed between genders for safety (all p-interaction ≥0.11). Conclusions This trial provides evidence that both women and men derived benefit from intensive statin therapy following ACS and thus gender should not be a factor in determining who should be treated with intensive statin therapy. PMID:21487089

  13. A theorem proving approach for automatically synthesizing visualizations of flow cytometry data.

    Science.gov (United States)

    Raj, Sunny; Hussain, Faraz; Husein, Zubir; Torosdagli, Neslisah; Turgut, Damla; Deo, Narsingh; Pattanaik, Sumanta; Chang, Chung-Che Jeff; Jha, Sumit Kumar

    2017-06-07

    Polychromatic flow cytometry is a popular technique that has wide usage in the medical sciences, especially for studying phenotypic properties of cells. The high-dimensionality of data generated by flow cytometry usually makes it difficult to visualize. The naive solution of simply plotting two-dimensional graphs for every combination of observables becomes impractical as the number of dimensions increases. A natural solution is to project the data from the original high dimensional space to a lower dimensional space while approximately preserving the overall relationship between the data points. The expert can then easily visualize and analyze this low-dimensional embedding of the original dataset. This paper describes a new method, SANJAY, for visualizing high-dimensional flow cytometry datasets. This technique uses a decision procedure to automatically synthesize two-dimensional and three-dimensional projections of the original high-dimensional data while trying to minimize distortion. We compare SANJAY to the popular multidimensional scaling (MDS) approach for visualization of small data sets drawn from a representative set of benchmarks, and our experiments show that SANJAY produces distortions that are 1.44 to 4.15 times smaller than those caused due to MDS. Our experimental results show that SANJAY also outperforms the Random Projections technique in terms of the distortions in the projections. We describe a new algorithmic technique that uses a symbolic decision procedure to automatically synthesize low-dimensional projections of flow cytometry data that typically have a high number of dimensions. Our algorithm is the first application, to our knowledge, of using automated theorem proving for automatically generating highly-accurate, low-dimensional visualizations of high-dimensional data.

  14. Effective As(III) Removal by A Multi-Charged Hydroacid Complex Draw Solute Facilitated Forward Osmosis-Membrane Distillation (FO-MD) Processes

    KAUST Repository

    Ge, Qingchun

    2016-01-29

    © 2016 American Chemical Society. Effective removal of As(III) from water by an oxalic acid complex with the formula of Na3[Cr(C2O4)3] (Na-Cr-OA) is demonstrated via an forward osmosis-membrane distillation (FO-MD) hybrid system in this study. Na-Cr-OA first proved its superiority as a draw solute with high water fluxes and negligible reverse fluxes in FO, then a systematic investigation of the Na-Cr-OA promoted FO process was conducted to ascertain the factors in As(III) removal. Relatively high water fluxes of 28 LMH under the FO mode and 74 LMH under the pressure retarded osmosis (PRO) mode were achieved when using a 1000 ppm As(III) solution as the feed and 1.0 M Na-Cr-OA as the draw solution at 60 °C. As(III) removal with a water recovery up to 21.6% (FO mode) and 48.3% (PRO mode) were also achieved in 2 h. An outstanding As(III) rejection with 30-3000 μg/L As(III) in the permeate was accomplished when As(III) feed solutions varied from 5 × 104 to 1 × 106 μg/L, superior to the best FO performance reported for As(III) removal. Incorporating MD into FO not only makes As(III) removal sustainable by reconcentrating the Na-Cr-OA solution simultaneously, but also reduces the As(III) concentration below 10 μg/L in the product water, meeting the WHO standard.

  15. Reinventing Grounded Theory: Some Questions about Theory, Ground and Discovery

    Science.gov (United States)

    Thomas, Gary; James, David

    2006-01-01

    Grounded theory's popularity persists after three decades of broad-ranging critique. In this article three problematic notions are discussed--"theory," "ground" and "discovery"--which linger in the continuing use and development of grounded theory procedures. It is argued that far from providing the epistemic security promised by grounded theory,…

  16. Educational outcomes for students enrolled in MD-PhD programs at medical school matriculation, 1995-2000: a national cohort study.

    Science.gov (United States)

    Jeffe, Donna B; Andriole, Dorothy A; Wathington, Heather D; Tai, Robert H

    2014-01-01

    To describe educational outcomes for a national cohort of students who enrolled in MD-PhD programs at medical school matriculation (MD-PhD matriculants). The authors used multivariate logistic regression to identify factors independently associated with overall MD-PhD program attrition (MD-only graduation or medical school withdrawal/dismissal) compared with MD-PhD program graduation among the 1995-2000 national cohort of MD-PhD matriculants at medical schools with and without Medical Scientist Training Program (MSTP) support. Of 2,582 MD-PhD matriculants, 1,885 (73.0%) were MD-PhD graduates, 597 (23.1%) were MD-only graduates, and 100 (3.9%) withdrew/were dismissed from medical school by July 2011. MD-PhD matriculants at non-MSTP-funded schools (adjusted odds ratio [AOR], 1.96; 95% confidence interval [CI], 1.60-2.41) and who had lower Medical College Admission Test scores (PhD program; matriculants who reported greater planned career involvement in research (AOR, 0.65; 95% CI, 0.51-0.84) and matriculated more recently (AOR, 0.90; 95% CI, 0.85-0.96) were less likely to leave the MD-PhD program. Gender, race/ethnicity, and premedical debt were not independently associated with overall MD-PhD program attrition. Most MD-PhD matriculants completed the MD-PhD program; most of those who left were MD-only graduates. Findings regarding variables associated with attrition can inform efforts to recruit and support students through successful completion of MD-PhD program requirements.

  17. Classical ground states of symmetric Heisenberg spin systems

    CERN Document Server

    Schmidt, H J

    2003-01-01

    We investigate the ground states of classical Heisenberg spin systems which have point group symmetry. Examples are the regular polygons (spin rings) and the seven quasi-regular polyhedra including the five Platonic solids. For these examples, ground states with special properties, e.g. coplanarity or symmetry, can be completely enumerated using group-theoretical methods. For systems having coplanar (anti-) ground states with vanishing total spin we also calculate the smallest and largest energies of all states having a given total spin S. We find that these extremal energies depend quadratically on S and prove that, under certain assumptions, this happens only for systems with coplanar S = 0 ground states. For general systems the corresponding parabolas represent lower and upper bounds for the energy values. This provides strong support and clarifies the conditions for the so-called rotational band structure hypothesis which has been numerically established for many quantum spin systems.

  18. Grounding of space structures

    Science.gov (United States)

    Bosela, P. A.; Fertis, D. G.; Shaker, F. J.

    1992-01-01

    Space structures, such as the Space Station solar arrays, must be extremely light-weight, flexible structures. Accurate prediction of the natural frequencies and mode shapes is essential for determining the structural adequacy of components, and designing a controls system. The tension pre-load in the 'blanket' of photovoltaic solar collectors, and the free/free boundary conditions of a structure in space, causes serious reservations on the use of standard finite element techniques of solution. In particular, a phenomenon known as 'grounding', or false stiffening, of the stiffness matrix occurs during rigid body rotation. This paper examines the grounding phenomenon in detail. Numerous stiffness matrices developed by others are examined for rigid body rotation capability, and found lacking. A force imbalance inherent in the formulations examined is the likely cause of the grounding problem, suggesting the need for a directed force formulation.

  19. Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE study: findings at 3 months

    Directory of Open Access Journals (Sweden)

    Reddy RK

    2013-09-01

    Full Text Available Rahul K Reddy,1 Maziar Lalezary,1 Stephen J Kim,1 Jeffrey A Kammer,1 Rachel W Kuchtey,1 Edward F Cherney,1 Franco M Recchia,2 Karen M Joos,1 Anita Agarwal,1 Janice C Law11Department of Ophthalmology, Vanderbilt University School of Medicine, Nashville, TN, USA; 2Tennessee Retina, PC, Nashville, TN, USABackground: The purpose of this paper is to report the 3-month findings of the Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE study.Methods: Eighty eyes of 40 participants undergoing vitrectomy were enrolled. Participants underwent baseline evaluation of the study (surgical and fellow (control eye that included: intraocular pressure, central corneal thickness, gonioscopy, cup-to-disc ratio measurement, color fundus and optic disc photography, automated perimetry, and optical coherence tomography of the macula and optic nerve. Evaluation was repeated at 3 months. Main outcome measures were changes in macula and retinal nerve fiber layer (RNFL thickness and intraocular pressure.Results: All participants completed follow-up. Mean cup-to-disc ratio of study and fellow eyes at baseline was 0.43 ± 0.2 and 0.46 ± 0.2, respectively, and 13% of participants had undiagnosed narrow angles. There was no significant change in intraocular pressure, cup-to-disc ratio, or pattern standard deviation in study eyes compared with baseline or fellow eyes at 3 months. Vision improved in all study eyes at 3 months compared with baseline (P = 0.013, but remained significantly worse than fellow eyes (P < 0.001. Central subfield and temporal peripapillary RNFL thickness were significantly greater in eyes with epiretinal membrane (P < 0.05, and resolution after surgery correlated with visual improvement (P < 0.05.Conclusion: The 3-month results do not indicate any increased risk for open-angle glaucoma but suggest that a relatively high percentage of eyes may be at risk of angle closure glaucoma. Temporal RNFL thickness and central subfield were increased

  20. Collison and Grounding

    DEFF Research Database (Denmark)

    Wang, G.; Ji, C.; Kuhala, P.

    2006-01-01

    COMMITTEE MANDATE Concern for structural arrangements on ships and floating structures with regard to their integrity and adequacy in the events of collision and grounding, with the view towards risk assessment and management. Consideration shall be given to the frequency of occurrence, the proba......COMMITTEE MANDATE Concern for structural arrangements on ships and floating structures with regard to their integrity and adequacy in the events of collision and grounding, with the view towards risk assessment and management. Consideration shall be given to the frequency of occurrence...

  1. Coding Issues in Grounded Theory

    Science.gov (United States)

    Moghaddam, Alireza

    2006-01-01

    This paper discusses grounded theory as one of the qualitative research designs. It describes how grounded theory generates from data. Three phases of grounded theory--open coding, axial coding, and selective coding--are discussed, along with some of the issues which are the source of debate among grounded theorists, especially between its…

  2. Studi Pengamanan Login Pada Sistem Informasi Akademik Menggunakan Otentifikasi One Time Password Berbasisis SMS dengan Hash MD5

    OpenAIRE

    Kartika Imam Santoso; Eko Sediyono; Suhartono Suhartono

    2016-01-01

    Pengamanan login untuk mengakses Sistem Informasi Akademik berbasis WEB, berupa pengamanan menggunakan OTP(One Time Password) yang di bangkitkan dengan Hash MD5 yang menghasilkan sebuah kode lewat SMS untuk otentikasi.Aplikasi OTP menggunakan masukan untuk hash MD5 dari tabel mahasiswa yang diambil adalah field NIM, No telp, danwaktu akses. Hasil dari fungsi hash tersebut menghasilkan 32 digit bilangan hexadesimal, kemudian mengganti denganangka bila ditemukan huruf di dalamnya. Selanjutnya d...

  3. Cross-sectional-derived determinants of satisfaction with physician-scientist training among Canadian MD/PhD graduates.

    Science.gov (United States)

    Twa, David D W; Skinnider, Michael A; Squair, Jordan W; Lukac, Christine D

    2017-01-01

    Although MD/PhD programs require considerable commitment on behalf of students and learning institutions, they serve as an integral means of training future physician-scientists; individuals who engage in translational medicine. As attrition from these programs has longstanding effects on the community of translational medicine and comes at substantial cost to MD/PhD programs, we aimed to identify determinants that were associated with satisfaction among MD/PhD graduates, a feature that might inform on limiting program attrition. Anonymized data from a national survey of 139 Canadian MD/PhD alumni was analyzed. Factor analysis was conducted to evaluate the reliability of three questions that measured satisfaction and logistic regression was used to assess the association of outcomes with 17 independent determinants. Eighty-one percent of graduates were satisfied with MD/PhD training. Factor analysis confirmed the reliability of the questions measuring satisfaction. Determinants of self-reported satisfaction with physician-scientist training included co-authorship of more than six manuscripts during MD/PhD training. Additionally, protected research time at the place of current appointment was strongly associated with agreement that MD/PhD training had helped career progression. Demographic variables were not associated with any satisfaction indicator. Taken together, the majority of Canadian MD/PhD graduates are satisfied with their physician-scientist training. Project collaboration leading to co-authorships and protected research time were strongly associated with training satisfaction among graduates. If the value of collaboration can be realized among current and future physician-scientist trainees who are dissatisfied with their training, this might ultimately reduce program attrition.

  4. Sub-Terrahertz Spectroscopy of E.COLI Dna: Experiment, Statistical Model, and MD Simulations

    Science.gov (United States)

    Sizov, I.; Dorofeeva, T.; Khromova, T.; Gelmont, B.; Globus, T.

    2012-06-01

    We will present result of combined experimental and computational study of sub-THz absorption spectra from Escherichia coli (E.coli) DNA. Measurements were conducted using a Bruker FTIR spectrometer with a liquid helium cooled bolometer and a recently developed frequency domain sensor operating at room temperature, with spectral resolution of 0.25 cm-1 and 0.03 cm-1, correspondingly. We have earlier demonstrated that molecular dynamics (MD) simulation can be effectively applied for characterizing relatively small biological molecules, such as transfer RNA or small protein thioredoxin from E. coli , and help to understand and predict their absorption spectra. Large size of DNA macromolecules ( 5 million base pairs for E. coli DNA) prevents, however, direct application of MD simulation at the current level of computational capabilities. Therefore, by applying a second order Markov chain approach and Monte-Carlo technique, we have developed a new statistical model to construct DNA sequences from biological cells. These short representative sequences (20-60 base pairs) are built upon the most frequently repeated fragments (2-10 base pairs) in the original DNA. Using this new approach, we constructed DNA sequences for several non-pathogenic strains of E.coli, including a well-known strain BL21, uro-pathogenic strain, CFT073, and deadly EDL933 strain (O157:H7), and used MD simulations to calculate vibrational absorption spectra of these strains. Significant differences are clearly present in spectra of strains in averaged spectra and in all components for particular orientations. The mechanism of interaction of THz radiation with a biological molecule is studied by analyzing dynamics of atoms and correlation of local vibrations in the modeled molecule. Simulated THz vibrational spectra of DNA are compared with experimental results. With the spectral resolution of 0.1 cm-1 or better, which is now available in experiments, the very easy discrimination between different

  5. Comparison of fission modes in {sup 252}Cf, {sup 257}Fm, and {sup 260}Md

    Energy Technology Data Exchange (ETDEWEB)

    van Aarle, J. [Laboratory for Materials Behaviour, Paul Scherrer Institute, CH-5232 Villigen-PSI (Switzerland); Siemon, K.; Patzelt, P. [Philipps University, FB 15---Kernchemie, D-35032 Marburg an der Lahn (Germany); Wild, J.F.; Lougheed, R.W. [University of California, Lawrence Livermore National Lab., Livermore, California 94551 (United States); Westmeier, W. [Dr. Westmeier GmbH, Moellnerweg 32, 35085 Ebsdorfergrund-Moelln (Germany)

    1998-10-01

    Although the spontaneous-fission properties of heavy actinides have been studied for well over 35 years, many interesting and informative details continue to come into light. During the last decade, the spontaneous fission of {sup 252}Cf, {sup 257}Fm and {sup 260}Md has been extensively investigated at the Philipps University of Marburg (1{endash}4), by means of a gadolinium-doped liquid scintillation tank for neutron counting and surface barrier detectors for fission fragment detection. The three nuclides represent the transition from the well-known asymmetric fission yield distribution, as it is characteristic for {sup 252}Cf, to a much more symmetrical one, found in the fission of {sup 260}Md. Therefore, trends in the dynamical changes of fission properties have been derived from these studies. For the spontaneous fission of {sup 252}Cf and {sup 260}Md, it was already shown that different fission modes, as proposed by theoretical calculations of Brosa et al. (5), could be separated, using the correlation between the neutrons emitted in a fission event and both the observed fission-fragment mass and the total kinetic energy (1, 2). In the case of {sup 257}Fm, no theoretical calculations for fission modes exist. However, from the fission properties of the two surrounding actinides, one can expect at least three different fission modes, namely two {open_quotes}standard{close_quotes} and the {open_quotes}supershort{close_quotes} mode. In this paper, results from the recent {sup 257}Fm experiment will be presented and compared to systematics extracted from the fission properties of other heavy actinides. {copyright} {ital 1998 American Institute of Physics.}

  6. Property Analysis of Exfoliated Graphite Nanoplatelets Modified Asphalt Model Using Molecular Dynamics (MD Method

    Directory of Open Access Journals (Sweden)

    Hui Yao

    2017-01-01

    Full Text Available This Molecular Dynamics (MD simulation paper presents a physical property comparison study between exfoliated graphite nanoplatelets (xGNP modified and control asphalt models, including density, glass transition temperature, viscosity and thermal conductivity. The three-component control asphalt model consists of asphaltenes, aromatics, and saturates based on previous references. The xGNP asphalt model was built by incorporating an xGNP and control asphalt model and controlling mass ratios to represent the laboratory prepared samples. The Amber Cornell Extension Force Field (ACEFF was used with assigned molecular electro-static potential (ESP charge from NWChem analysis. After optimization and ensemble relaxation, the properties of the control and xGNP modified asphalt models were computed and analyzed using the MD method. The MD simulated results have a similar trend as the test results. The property analysis showed that: (1 the density of the xGNP modified model is higher than that of the control model; (2 the glass transition temperature of the xGNP modified model is closer to the laboratory data of the Strategic Highway Research Program (SHRP asphalt binders than that of the control model; (3 the viscosities of the xGNP modified model at different temperatures are higher than those of the control model, and it coincides with the trend in the laboratory data; (4 the thermal conductivities of the xGNP modified asphalt model are higher than those of the control asphalt model at different temperatures, and it is consistent with the trend in the laboratory data.

  7. A workshop on leadership for senior MD-PhD students.

    Science.gov (United States)

    Meador, Catherine B; Parang, Bobak; Musser, Melissa A; Haliyur, Rachana; Owens, David A; Dermody, Terence S

    2016-01-01

    Leadership skills are essential for a successful career as a physician-scientist, yet many MD-PhD training programs do not offer formal training in leadership. The Vanderbilt Medical Scientist Training Program (MSTP) previously established a 2-day leadership workshop that has been held biennially since 2006 for students in the first and second years of the graduate school portion of combined MD and PhD training (G1/G2 students). Workshop attendees have consistently rated this workshop as a highly effective experience. However, opportunities for structured training in leadership competencies during the subsequent 3-5 years of MD-PhD training are limited. Given the success of the G1/G2 leadership workshop and the need for continuity in this model of leadership training, we developed a half-day workshop for MSTP students in the clinical years of medical school (M3/M4 students) to foster continued training in leadership. Our workshop curriculum, based in part on original cases drafted by Vanderbilt MSTP students, provides concrete strategies to manage conflict and navigate leadership transitions in the physician-scientist career path. The curriculum emphasizes both short-term competencies, such as effective participation as a member of a clinical team, and long-term competencies, such as leadership of a research team, division, or department. Our inaugural senior leadership workshop, held in August, 2015, was judged by student participants to be well organized and highly relevant to leadership concepts and skills. It will be offered biennially in our training curriculum for M3 and M4 MSTP students.

  8. MD study of pyrimidine base damage on DNA and its recognition by repair enzyme

    Energy Technology Data Exchange (ETDEWEB)

    Pinak, M. [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan)

    2000-05-01

    The molecular dynamics (MD) simulation was used on the study of two specific damages of pyrimidine bases of DNA. Pyrimidine bases are major targets either of free radicals induced by ionizing radiation in DNA surrounding environment or UV radiation. Thymine dimer (TD) is UV induced damage, in which two neighboring thymines in one strand are joined by covalent bonds of C(5)-C(5) and C(6)-C(6) atoms of thymines. Thymine glycol (TG) is ionizing radiation induced damage in which the free water radical adds to unsaturated bond C(5)-C(6) of thymine. Both damages are experimentally suggested to be mutagenetic and carcinogenic unless properly repaired by repair enzymes. In the case of MD of TD, there is detected strong kink around the TD site that is not observed in native DNA. In addition there is observed the different value of electrostatic energy at the TD site - negative '-10 kcal/mol', in contrary to nearly neutral value of native thymine site. Structural changes and specific electrostatic energy - seems to be important for proper recognition of TD damaged site, formation of DNA-enzyme complex and thus for subsequent repair of DNA. In the case of TG damaged DNA there is major structural distortion at the TG site, mainly the increased distance between TG and the C5' of adjacent nucleotide. This enlarged gap between the neighboring nucleotides may prevent the insertion of complementary base during replication causing the replication process to stop. In which extend this structural feature together with energy properties of TG contributes to the proper recognition of TG by repair enzyme Endonuclease III is subject of further computational MD study. (author)

  9. Grounding in Instant Messaging

    Science.gov (United States)

    Fox Tree, Jean E.; Mayer, Sarah A.; Betts, Teresa E.

    2011-01-01

    In two experiments, we investigated predictions of the "collaborative theory of language use" (Clark, 1996) as applied to instant messaging (IM). This theory describes how the presence and absence of different grounding constraints causes people to interact differently across different communicative media (Clark & Brennan, 1991). In Study 1, we…

  10. Mechanics of Ship Grounding

    DEFF Research Database (Denmark)

    Pedersen, Preben Terndrup

    1996-01-01

    In these notes first a simplified mathematical model is presented for analysis of ship hull loading due to grounding on relatively hard and plane sand, clay or rock sea bottoms. In a second section a more rational calculation model is described for the sea bed soil reaction forces on the sea bott...

  11. Informed Grounded Theory

    Science.gov (United States)

    Thornberg, Robert

    2012-01-01

    There is a widespread idea that in grounded theory (GT) research, the researcher has to delay the literature review until the end of the analysis to avoid contamination--a dictum that might turn educational researchers away from GT. Nevertheless, in this article the author (a) problematizes the dictum of delaying a literature review in classic…

  12. Grounding Anger Management

    Directory of Open Access Journals (Sweden)

    Odis E. Simmons, PhD

    2017-06-01

    Full Text Available One of the things that drew me to grounded theory from the beginning was Glaser and Strauss’ assertion in The Discovery of Grounded Theory that it was useful as a “theoretical foothold” for practical applications (p. 268. From this, when I was a Ph.D student studying under Glaser and Strauss in the early 1970s, I devised a GT based approach to action I later came to call “grounded action.” In this short paper I’ll present a very brief sketch of an anger management program I developed in 1992, using grounded action. I began my research by attending a two-day anger management training workshop designed for training professionals in the most commonly used anger management model. Like other intervention programs I had seen, this model took a psychologizing and pathologizing approach to the issue. Following this, I sat through the full course of an anger management program that used this model, observing the reactions of the participants and the approach of the facilitator. Following each session I conducted open-ended interviews with most of the participants, either individually or in groups of two or three. I had also done previous research in counseling and social work contexts that turned out to be very relevant to an anger management program design.

  13. Korea's School Grounds Projects

    Science.gov (United States)

    Park, Joohun

    2003-01-01

    This article describes two projects which Korea has undertaken to improve its school grounds: (1) the Green School Project; and (2) the School Forest Pilot Project. The Korean Ministry of Education and Human Resources Development (MOE&HRI) recently launched the Green School Project centred on existing urban schools with poor outdoor…

  14. Singlet Ground State Magnetism:

    DEFF Research Database (Denmark)

    Loidl, A.; Knorr, K.; Kjems, Jørgen

    1979-01-01

    The magneticGamma 1 –Gamma 4 exciton of the singlet ground state system TbP has been studied by inelastic neutron scattering above the antiferromagnetic ordering temperature. Considerable dispersion and a pronounced splitting was found in the [100] and [110] directions. Both the band width and th...

  15. An obesity-like gene MdTLP7 from apple (Malus × domestica) enhances abiotic stress tolerance.

    Science.gov (United States)

    Du, Fan; Xu, Jia-Ning; Zhan, Chun-Yan; Yu, Zhi-Bo; Wang, Xiao-Yun

    2014-03-07

    Tubby-like proteins (TLPs) are found in a broad range of multicellular organisms. In mammals, genetic mutation of tubby or other TLPs can result in certain disease phenotypes related to animal specific characters: obesity, retinal degeneration, hearing loss, et al. Plants also harbor a large number of TLP genes, but the information in plants is far more limited. We identified a highly up-regulated obesity-like gene, MdTLP7, in our previous study of apple differential gene expression profile under chilling, indicating its possible role in plant abiotic stress tolerance. cDNA of MdTLP7 was amplified and expressed in Escherichia coli. In the solid and solution medium, the rate of growth and the quantity of the cell carrying MdTLP7 gene were significantly more than that of empty vector under salt and temperature stresses. To identify the functional region, serial deletion from both N-terminus and C-terminus of MdTLP7 was performed. In 415 amino acid polypeptide chain of MdTLP7, a middle conservative fragment (120-310 amino acid residues) played vital roles in stress tolerance. This fragment was involved in β barrel of Tubby domain according to the model of Tubby domain. All above results suggested MdTLP7 confers stress-tolerance to E. coli cell against abiotic stresses. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. Human microbiome science: vision for the future, Bethesda, MD, July 24 to 26, 2013

    Science.gov (United States)

    2014-01-01

    A conference entitled ‘Human microbiome science: Vision for the future’ was organized in Bethesda, MD from July 24 to 26, 2013. The event brought together experts in the field of human microbiome research and aimed at providing a comprehensive overview of the state of microbiome research, but more importantly to identify and discuss gaps, challenges and opportunities in this nascent field. This report summarizes the presentations but also describes what is needed for human microbiome research to move forward and deliver medical translational applications.

  17. Neutron emission as a function of fragment energy in the spontaneous fission of /sup 260/Md

    Energy Technology Data Exchange (ETDEWEB)

    Wild, J.F.; van Aarle, J.; Westmeiser, W.; Lougheed, R.W.; Hulet, E.K.; Moody, K.J.; Dougan, R.J.; Brandt, R.; Patzelt, P.

    1989-04-19

    We have made the first measurement of the number of neutrons emitted in the spontaneous fission of a nuclide in which very high fragment energies dominate the fission process. In bombardments of /sup 254/Es, we produced 28-d /sup 260/Md, which was neutron-counted in a 1-m-diam spherical tank containing a Gd-doped scintillator solution. The average number of neutrons emitted per fission is only 2.58 +- 0.11, substantially less than for other actinides. A direct correlation of neutron multiplicity with fragment excitation energy is clearly demonstrated. 3 refs., 5 figs.

  18. Prompt neutron emission from the spontaneous fission of sup 260 Md

    Energy Technology Data Exchange (ETDEWEB)

    Wild, J.F.; van Aarle, J.; Westmeier, W.; Lougheed, R.W.; Hulet, E.K.; Moody, K.J.; Dougan, R.J.; Koop, E.; Glaser, R.E.; Brandt, R.; Patzelt, P. (University of California, Lawrence Livermore National Laboratory, Livermore California 94551 (US) Philipps University, D-3550, Marburg an der Lahn, (Federal Republic of Germany))

    1990-02-01

    We have made the first measurement of the number of neutrons emitted from the spontaneous fission of a nuclide in which very high fragment energies dominate the fission process. In bombardments of {sup 254}Es, we produced a large sample of 28-d {sup 260}Md, which was neutron counted in a 1-m-diameter spherical tank containing a Gd-doped scintillator solution. The average number of neutrons emitted per fission is only 2.58{plus minus}0.11, substantially less than for other actinides. A linear dependence of neutron multiplicity on fragment-excitation energy is observed to the highest values of total kinetic energy.

  19. The role of MD and MBA training in the professional development of a physician: a survey of 30 years of graduates from the Wharton Health Care Management Program.

    Science.gov (United States)

    Patel, Mitesh S; Arora, Vishal; Patel, Mamta S; Kinney, June M; Pauly, Mark V; Asch, David A

    2014-09-01

    The number of medical schools offering MD and MBA training has increased fivefold in the last two decades. The authors evaluated graduates' perceptions of the role of such training on their career and professional development. In 2011, the authors surveyed physician graduates from the Wharton School MBA Program in Heath Care Management at the University of Pennsylvania from 1981 to 2010. Survey responses were analyzed and evaluated using grounded theory. Among 247 eligible graduates, 59.9% (148/247) completed the questionnaire and 89.9% (133/148) of them provided free-text responses. Approximately 85.1% (126/148) of respondents were male and 79.7% (118/148) entered residency training; however, both rates declined slightly over time. Among respondents within their first decade after graduation, 46.2% (24/52) reported clinical practice as their primary work sector compared with 39.5% (15/38) among respondents 11 to 20 years after graduation and 19.2% (5/26) of respondents 21 to 30 years after graduation. Overall, graduates reported mostly positive attitudes and often noted the benefits of career acceleration, professional flexibility, and credibility in multidisciplinary domains. The few negative remarks were focused on the opportunity cost of time and how peers in one discipline may negatively perceive the role of the other discipline's degree. Graduates with an MD and MBA report mostly positive attitudes towards their training, and many are pursuing leadership and primarily nonclinical roles later in their careers. These findings reveal new insights for policies affecting physician workforce. Further study is necessary to evaluate whether similar trends exist more broadly.

  20. Users manual on database of the Piping Reliability Proving Tests at the Japan Atomic Energy Research Institute

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-09-01

    Japan Atomic Energy Research Institute(JAERI) conducted Piping Reliability Proving Tests from 1975 to 1992 based upon the contracts between JAERI and Science and Technology Agency of Japan under the auspices of the special account law for electric power development promotion. The purposes of those tests are to prove the structural reliability of the primary cooling piping constituting a part of the pressure boundary in the water reactor power plants. The tests with large experimental facilities had ended already in 1990. After that piping reliability analysis by the probabilistic method followed until 1992. This report describes the users manual on databases about the test results using the large experimental facilities. Objectives of the piping reliability proving tests are to prove that the primary piping of the water reactor (1) be reliable throughout the service period, (2) have no possibility of rupture, (3) bring no detrimental influence on the surrounding instrumentations or equipments near the break location. The research activities using large scale piping test facilities are described. The present report does the database about the test results pairing the former report. With these two reports, all the feature of Piping Reliability Proving Tests is made clear. Briefings of the tests are described also written in Japanese or English. (author)