FY2011 Annual Progress Report for Advanced Combustion Engine Research and Development

Energy Technology Data Exchange (ETDEWEB)

none,

2011-12-01

Annual Progress Report for the Advanced Combustion Engine Research and Development (R&D) subprogram supporting the mission of the Vehicle Technologies Program by removing the critical technical barriers to commercialization of advanced internal combustion engines (ICEs) for passenger and commercial vehicles that meet future federal emissions regulations.

Annual report on reactor safety research projects. Reporting period 2011. Progress report

International Nuclear Information System (INIS)

2011-01-01

Within its competence for energy research the Federal Ministry of Economics and Technology (BMWi) sponsors research projects on the safety of nuclear power plants currently in operation. The objective of these projects is to provide fundamental knowledge, procedures and methods to contribute to realistic safety assessments of nuclear installations, to the further development of safety technology and to make use of the potential of innovative safety-related approaches. The Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS)mbH, by order of the BMWi, continuously issues information on the status of such research projects by publishing semi-annual and annual progress reports within the series of GRSF- Fortschrittsberichte (GRS-F-Progress Reports). Each progress report represents a compilation of individual reports about the objectives, work performed, results achieved, next steps of the work etc. The individual reports are prepared in a standard form by the research organisations themselves as documentation of their progress in work. The progress reports are published by the Project Management Agency/Authority Support Division of GRS. The reports as of the year 2000 are available in the Internet-based information system on results and data of reactor safety research (http://www.grs-fbw.de). The compilation of the reports is classified according to the classification system ''Joint Safety Research Index (JSRI)''. The reports are arranged in sequence of their project numbers. It has to be pointed out that the authors of the reports are responsible for the contents of this compilation. The BMWi does not take any responsibility for the correctness, exactness and completeness of the information nor for the observance of private claims of third parties. (orig.)

Annual report on reactor safety research projects. Reporting period 2014. Progress report

Energy Technology Data Exchange (ETDEWEB)

NONE

2014-07-01

Within its competence for energy research the Federal Ministry for Economic Affairs and Energy (BMWi) sponsors research projects on the safety of nuclear power plants currently in operation. The objective of these projects is to provide fundamental knowledge, procedures and methods to contribute to realistic safety assessments of nuclear installations, to the further development of safety technology and to make use of the potential of innovative safety-related approaches. The Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) gGmbH, by order of the BMWi, continuously issues information on the status of such research projects by publishing semi-annual and annual progress reports within the series of GRS-F-Fortschrittsberichte (GRS-F-Progress Reports). Each progress report represents a compilation of individual reports about the objectives, work performed, results achieved, next steps of the work etc. The individual reports are prepared in a standard form by the research organisations themselves as documentation of their progress in work. The progress reports are published by the Project Management Agency/Authority Support Division of GRS. The reports as of the year 2000 are available in the lnternet-based information system on results and data of reactor safety research (http://www.grs-fbw.de). The compilation of the reports is classified according to the classification system ''Joint Safety Research Index (JSRI)''. The reports are arranged in sequence of their project numbers. lt has to be pointed out that the authors of the reports are responsible for the contents of this compilation. The BMWi does not take any responsibility for the correctness, exactness and completeness of the information nor for the observance of private claims of third parties.

Annual report on reactor safety research projects. Reporting period 2013. Progress report

International Nuclear Information System (INIS)

2013-01-01

Within its competence for energy research the Federal Ministry of Economics and Technology (BMWi) sponsors research projects on the safety of nuclear power plants currently in operation. The objective of these projects is to provide fundamental knowledge, procedures and methods to contribute to realistic safety assessments of nuclear installations, to the further development of safety technology and to make use of the potential of innovative safety-related approaches. The Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS)mbH, by order of the BMWi, continuously issues information on the status of such research projects by publishing semi-annual and annual progress reports within the series of GRSF- Fortschrittsberichte (GRS-F-Progress Reports). Each progress report represents a compilation of individual reports about the objectives, work performed, results achieved, next steps of the work etc. The individual reports are prepared in a standard form by the research organisations themselves as documentation of their progress in work. The progress reports are published by the Project Management Agency/Authority Support Division of GRS. The reports as of the year 2000 are available in the Internet-based information system on results and data of reactor safety research (http://www.grs-fbw.de). The compilation of the reports is classified according to the classification system ''Joint Safety Research Index (JSRI)''. The reports are arranged in sequence of their project numbers. It has to be pointed out that the authors of the reports are responsible for the contents of this compilation. The BMWi does not take any responsibility for the correctness, exactness and completeness of the information nor for the observance of private claims of third parties. (orig.)

Annual report on reactor safety research projects. Reporting period 2015. Progress report

International Nuclear Information System (INIS)

2015-01-01

Within its competence for energy research the Federal Ministry for Economic Affairs and Energy (BMWi) sponsors research projects on the safety of nuclear power plants currently in operation. The objective of these projects is to provide fundamental knowledge, procedures and methods to contribute to realistic safety assessments of nuclear installations, to the further development of safety technology and to make use of the potential of innovative safety-related approaches. The Gesellschaft tor Anlagen- und Reaktorsicherheit (GRS) gGmbH, by order of the BMWi, continuously issues information on the status of such research projects by publishing semi-annual and annual progress reports within the series of GRS-F-Fortschrittsberichte (GRS-F-Progress Reports). Each progress report represents a compilation of individual reports about the objectives, work performed, results achieved, next steps of the work etc. The individual reports are ·' prepared in a standard form by the research organisations themselves as documentation of their progress in work. The progress reports are published by the Project Management Agency/Authority Support Division of GRS. The reports as of the year 2000 are available in the lnternet-based information system on results and data of reactor safety research (http://www.grs-fbw.de). The compilation of the reports is classified according to the classification system ''Joint Safety Research Index (JSRI)''. The reports are arranged in sequence of their project numbers. it has to be pointed out that the authors of the reports are responsible for the contents of this compilation. The BMWi does not take any responsibility for the correctness, exactness and completeness of the information nor for the observance of private claims of third parties.

Laboratory Directed Research and Development FY 2000 Annual Progress Report

Energy Technology Data Exchange (ETDEWEB)

Los Alamos National Laboratory

2001-05-01

This is the FY00 Annual Progress report for the Laboratory Directed Research and Development (LDRD) Program at Los Alamos National Laboratory. It gives an overview of the LDRD Program, summarizes progress on each project conducted during FY00, characterizes the projects according to their relevance to major funding sources, and provides an index to principal investigators. Project summaries are grouped by LDRD component: Directed Research and Exploratory Research. Within each component, they are further grouped into the ten technical categories: (1) atomic, molecular, optical, and plasma physics, fluids, and beams, (2) bioscience, (3) chemistry, (4) computer science and software engineering, (5) engineering science, (6) geoscience, space science, and astrophysics, (7) instrumentation and diagnostics, (8) materials science, (9) mathematics, simulation, and modeling, and (10) nuclear and particle physics.

The community's research and development programme on decommissioning of nuclear installations. Fourth annual progress report 1988

International Nuclear Information System (INIS)

Anon.

1989-01-01

This is the fourth annual progress report on the European Community's programme (1984-88) of research on the decommissioning of nuclear installations. It shows the status of the programme at 31 December 1988. The fourth progress report describes the objectives, scope and work programme of the 72 research contracts concluded, as well as the progress of work achieved and the results obtained in 1988

The Community's research and development programme on decommissioning of nuclear installations. Third annual progress report 1987

International Nuclear Information System (INIS)

1988-01-01

This is the third annual progress report of the European Community's programme (1984-88) of research on the decommissioning of nuclear installations. It shows the status of the programme on 31 December 1987. The third progress report describes the objectives, scope and work programme of the 69 research contracts concluded, as well as the progress of work achieved and the results obtained in 1987

The Community's research and development programme on decommissioning of nuclear installations (1989-1993). Annual progress report 1991

International Nuclear Information System (INIS)

1992-01-01

This is the second annual progress report of the European Community's programme (1989-93) of research on decommissioning of nuclear installations. It shows the status of the programme on 31 December 1991. This second progress report summarizes the objectives, scope and work programme of the 76 research contracts concluded, as well as the progress of work achieved and the results obtained in 1991

76 FR 45862 - Agency Information Collection Activities: New Collection; Semi-Annual Progress Report for...

Science.gov (United States)

2011-08-01

... the Services, Training, Education and Policies to Reduce Domestic Violence, Dating Violence, Sexual... Collection; Semi- Annual Progress Report for Grantees From the Services, Training, Education and Policies To Reduce Domestic Violence, Dating Violence, Sexual Assault and Stalking in Secondary Schools Grant Program...

Commercial waste treatment program annual progress report for FY 1983

Energy Technology Data Exchange (ETDEWEB)

McElroy, J.L.; Burkholder, H.C. (comps.)

1984-02-01

This annual report describes progress during FY 1983 relating to technologies under development by the Commercial Waste Treatment Program, including: development of glass waste form and vitrification equipment for high-level wastes (HLW); waste form development and process selection for transuranic (TRU) wastes; pilot-scale operation of a radioactive liquid-fed ceramic melter (LFCM) system for verifying the reliability of the reference HLW treatment proces technology; evaluation of treatment requirements for spent fuel as a waste form; second-generation waste form development for HLW; and vitrification process control and product quality assurance technologies.

The Community's research and development programme on decommissioning of nuclear installations. Second annual progress report (year 1986)

International Nuclear Information System (INIS)

1987-01-01

This is the second annual progress report of the European Community's programme (1984-88) of research on the decommissioning of nuclear installations. It shows the status of the programme on 31 December 1986. This second progress report describes the objectives, scope and work programme of the 58 research contracts concluded, as well as the progress of work achieved and the results obtained in 1986

FY2014 Energy Storage R&D Annual Progress Report

Energy Technology Data Exchange (ETDEWEB)

none,

2015-03-01

The Energy Storage research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for projects focusing on batteries for plug-in electric vehicles. Program targets focus on overcoming technical barriers to enable market success including: (1) significantly reducing battery cost, (2) increasing battery performance (power, energy, durability), (3) reducing battery weight & volume, and (4) increasing battery tolerance to abusive conditions such as short circuit, overcharge, and crush. This report describes the progress made on the research and development projects funded by the Energy Storage subprogram in 2014. You can download individual sections at the following website, http://energy.gov/eere/vehicles/downloads/vehicle-technologies-office-2014-energy-storage-rd-annual-report.

The UK fuel poverty strategy: 5th annual progress report 2007

International Nuclear Information System (INIS)

2007-12-01

This fifth annual progress report details government progress in 2007 in tackling fuel poverty and movement towards targets. The United Kingdom were the first country in the world to recognise the issue of fuel poverty and to put in place measures to tackle the issue, including spending 20 billion pounds sterling on benefits and programmes since the year 2000. The report covers progress to date, schemes and initiatives to tackle fuel poverty, the energy market and looks ahead to the future. Progress and development of the schemes across the devolved nations are also considered. This report is the first to publish the Government's proposals for the Carbon Emissions Reduction Target (CERT) priority group, which were laid before Parliament on 5th December 2007. This report is the first to present the fuel poverty figures for 2005, and shows the effects of rising energy prices. The Government continues to take action to ensure that the energy market is working properly, and to encourage reform in the EU on energy market liberalisation - this should reduce pressure on prices. Those in fuel poverty have much to gain by switching supplier and this report outlines the action taken by Ofgem and Energywatch to encourage this

76 FR 30388 - Agency Information Collection Activities: New collection Semi-Annual Progress Report for Grantees...

Science.gov (United States)

2011-05-25

... Grantees from the Services, Training, Education and Policies to Reduce Domestic Violence, Dating Violence... collection Semi- Annual Progress Report for Grantees From the Services, Training, Education and Policies To Reduce Domestic Violence, Dating Violence, Sexual Assault and Stalking in Secondary Schools Grant Program...

Nuclear Structure Group annual progress report June 1974 -May 1975

International Nuclear Information System (INIS)

1975-06-01

This is the first annual progress report of the Nuclear Structure Group of the University of Birmingham. The introduction lists the main fields of study of the Group as: polarisation penomena and optical model studies using 3 He and 4 He probes; photonuclear physics; heavy-ion physics; and K- meson physics. The programme is related to particle accelerators at Birmingham, Oxford, Harwell and the Rutherford Laboratory. The body of the report consists of summaries of 38 experiments undertaken by members of the Group. The third section contains 10 notes on instrumentation topics. Appendices contain lists of (a) personnel, (b) papers published or submitted during the period. (U.K.)

Progress of emphysema in severe α1-antitrypsin deficiency as assessed by annual CT

International Nuclear Information System (INIS)

Dirksen, A.; Friis, M.; Olesen, K.P.

1997-01-01

Purpose: To assess serial CT as a measure of the progress of emphysema in patients with severe α 1 -antitrypsin deficiency (phenotype PiZ). Material and Methods: In a randomized placebo-controlled study of α 1 -antitrypsin augmentation therapy, 22 patients with moderate emphysema were followed for 2-4 years with an annual lung CT. The images were analysed by means of semiautomatic lung detection, and the degree of emphysema was quantitated by the density-mask and the percentile methods. The influence of lung volume was standardised by a regression model. Results: A highly significant decline in Hounsfield units (HU) was found in low-density areas, corresponding to a mean (SE) annual loss of lung tissue of 2.1 (0.4) g/l lung volume. Analysis of a single slice at 5 cm below the level of the carina gave comparable results: 2.4 (0.4) g/l. Conclusion: Serial CT is a sensitive measure of the progress of emphysema in patients with severe α 1 -antitrypsin deficiency. (orig.)

IAEA and EU Review Progress on Cooperation, Agree on Next Steps at Annual Meeting

International Nuclear Information System (INIS)

2018-01-01

The International Atomic Energy Agency (IAEA) and the European Union (EU) reviewed progress achieved in working together on a range of nuclear activities and agreed to further enhance cooperation during their sixth annual Senior Officials Meeting in Vienna. The talks on 8 February at the IAEA’s headquarters provided a forum for exchanging views on strengthening collaboration on nuclear safety, security, safeguards, sustainable development, nuclear energy research and increasing innovation. The two organizations welcomed the fruitful cooperation and progress achieved over the past years. They agreed to deepen cooperation in several areas, particularly in the promotion of nuclear applications for sustainable development.

Pennsylvania State University Breazeale Nuclear Reactor. Thirtieth annual progress report, July 1, 1984-June 30, 1985

International Nuclear Information System (INIS)

Levine, S.H.; Totenbier, R.E.

1985-08-01

This report is the thirtieth annual progress report of the Pennsylvania State University Breazeale Nuclear Reactor and covers such topics as: personnel; reactor facility; cobalt-60 facility; education and training; Radionuclear Application Laboratory; Low Level Radiation Monitoring Laboratory; and facility research utilization

Western Research Institute: Annual technical progress report, October 1987--September 1988

Energy Technology Data Exchange (ETDEWEB)

1988-12-01

This report describes the technical progress made by the Western Research Institute of the University of Wyoming Research Institute of the University of Wyoming Research Corporation on work performed for the period October 1, 1987 through September 30, 1988. This research involves five resource areas: oil shale, tar sand, underground coal gasification, advanced process technology, and advanced fuels research. Under the terms of the cooperative agreement, an annual project plan has been approved by DOE. The work reported herein reflects the implementation of the research in the plan and follows the structure used therein. 49 refs., 32 figs., 87 tabs.

Annual report of waste generation and pollution prevention progress, 1994

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-09-01

This Report summarizes the waste generation and pollution prevention activities of the major operational sites in the Department of Energy (DOE). We are witnessing progress in waste reduction from routine operations that are the focus of Department-wide reduction goals set by the Secretary on May 3,1996. The goals require that by the end of 1999, we reduce, recycle, reuse, and otherwise avoid waste generation to achieve a 50 percent reduction over 1993 levels. This Report provides the first measure of our progress in waste reduction and recycling against our 1993 waste generation baseline. While we see progress in reducing waste from our normal operations, we must begin to focus attention on waste generated by cleanup and facilities stabilization activities that are the major functions of the Office of Environmental Management. Reducing the generation of waste is one of the seven principles that I have established for the Office of Environmental Management Ten Year Plan. As part of our vision to complete a major portion of the environmental cleanup at DOE sites over the next ten years, we must utilize the potential of the pollution prevention program to reduce the cost of our cleanup program. We have included the Secretarial goals as part of the performance measures for the Ten Year Plan, and we are committed to implementing pollution prevention ideas. Through the efforts of both Federal and contractor employees, our pollution prevention program has reduced waste and the cost of our operations. I applaud their efforts and look forward to reporting further waste reduction progress in the next annual update of this Report.

Annual report of waste generation and pollution prevention progress, 1994

International Nuclear Information System (INIS)

1996-09-01

This Report summarizes the waste generation and pollution prevention activities of the major operational sites in the Department of Energy (DOE). We are witnessing progress in waste reduction from routine operations that are the focus of Department-wide reduction goals set by the Secretary on May 3,1996. The goals require that by the end of 1999, we reduce, recycle, reuse, and otherwise avoid waste generation to achieve a 50 percent reduction over 1993 levels. This Report provides the first measure of our progress in waste reduction and recycling against our 1993 waste generation baseline. While we see progress in reducing waste from our normal operations, we must begin to focus attention on waste generated by cleanup and facilities stabilization activities that are the major functions of the Office of Environmental Management. Reducing the generation of waste is one of the seven principles that I have established for the Office of Environmental Management Ten Year Plan. As part of our vision to complete a major portion of the environmental cleanup at DOE sites over the next ten years, we must utilize the potential of the pollution prevention program to reduce the cost of our cleanup program. We have included the Secretarial goals as part of the performance measures for the Ten Year Plan, and we are committed to implementing pollution prevention ideas. Through the efforts of both Federal and contractor employees, our pollution prevention program has reduced waste and the cost of our operations. I applaud their efforts and look forward to reporting further waste reduction progress in the next annual update of this Report

Health physics division annual progress report for period ending June 30, 1977

Energy Technology Data Exchange (ETDEWEB)

1978-07-01

This annual progress report follows, as in the past, the organizational structure of the Health Physics Division. Each part is a report of work done by a section of the division: Assessment and Technology Section (Part I), headed by H.W. Dickson; Biological and Radiation Physics Section (Part II), H.A. Wright; Chemical Physics and Spectroscopy Section (Part III), W.R. Garrett; Emergency Technology Section (Part IV), C.V. Chester, Medical Physics and Internal Dosimetry Section (Part V), K.E. Cowser; and the Analytic Dosimetry and Education Group (Part VI), J.E. Turner.

FY2009 Annual Progress Report for Advanced Combustion Engine Research and Development

Energy Technology Data Exchange (ETDEWEB)

none,

2009-12-01

Fiscal Year 2009 Annual Progress Report for the Advanced Combustion Engine Research and Development (R&D) subprogram. The Advanced Combustion Engine R&D subprogram supports the mission of the VTP program by removing the critical technical barriers to commercialization of advanced internal combustion engines (ICEs) for passenger and commercial vehicles that meet future Federal emissions regulations. Dramatically improving the efficiency of ICEs and enabling their introduction in conventional as well as hybrid electric vehicles is the most promising and cost-effective approach to increasing vehicle fuel economy over the next 30 years.

[Effect of inhibitors serine/threonine protein kinases and protein phosphatases on mitosis progression of synchronized tobacco by-2 cells].

Science.gov (United States)

Sheremet, Ia A; Emets, A I; Azmi, A; Vissenberg, K; Verbelen, J-P; Blium, Ia B

2012-01-01

In order to investigate the role of various serine/ threonine protein kinases and protein phosphatases in the regulation of mitosis progression in plant cells the influence of cyclin-dependent (olomoucine) and Ca2+ -calmodulin-dependent (W7) protein kinases inhibitors, as well as protein kinase C inhibitors (H7 and staurosporine) and protein phosphatases inhibitor (okadaic acid) on mitosis progression in synchronized tobacco BY-2 cells has been studied. It was found that BY-2 culture treatment with inhibitors of cyclin dependent protein kinases and protein kinase C causes prophase delay, reduces the mitotic index and displaces of mitotic peak as compare with control cells. Inhibition of Ca2+ -calmodulin dependent protein kinases enhances the cell entry into prophase and delays their exit from mitosis. Meanwhile inhibition of serine/threonine protein phosphatases insignificantly enhances of synchronized BY-2 cells entering into all phases of mitosis.

Risø annual report 2001

DEFF Research Database (Denmark)

2002-01-01

In this annual report, we present a small selection of Risø’s achievements in 2001. A more detailed review of Risø’s projects can be found in the Risø Annual Accounts for 2001 as well as in the annual progress reports prepared by the individual researchdepartments.......In this annual report, we present a small selection of Risø’s achievements in 2001. A more detailed review of Risø’s projects can be found in the Risø Annual Accounts for 2001 as well as in the annual progress reports prepared by the individual researchdepartments....

Annual progress report

International Nuclear Information System (INIS)

Russek, A.

1975-06-01

Progress has been made in calculation of cross-sections for dielectronic and radiative recombination when hot electrons are incident on partially stripped impurity ions. Calculations were completed for the cases of 1 keV and 10 keV electrons incident on ions of arbitrary Z with ionization state consistent with a 1 keV plasma temperature. It was found that dielectronic recombination dominates radiative recombination by a factor of 100 at 1 keV incident electron energy to a factor of 1000 at 10 keV incident electron energy. The work is now being extended to other plasma temperatures and is being improved by more accurate calculation of the matrix elements involved. Progress was also made in the calculation of accurate bremsstrahlung and higher order radiative processes which also occur when hot electrons are incident on partially stripped impurity ions. Formal expressions for the matrix elements have been obtained for cross-sections in a fully relativistic partial wave analysis for bremsstrahlung radiation both with and without electron excitation of the target ion. Final evaluation now awaits the evaluation of the relativistic radial integrals involved in these matrix elements. (U.S.)

2000 Annual Progress Report for Fuels for Advanced CIDI Engines and Fuel Cells

Energy Technology Data Exchange (ETDEWEB)

Chalk, S.

2000-12-11

The Department of Energy's Office of Transportation Technologies Fiscal Year (FY) 2000 Annual Progress Report for the Fuels for Advanced CIDI Engines and Fuel Cells Program highlights progress achieved during FY 2000 and comprises 22 summaries of industry and National Laboratory projects that were conducted. The report provides an overview of the exciting work being conducted to tackle the tough technical challenges associated with developing clean burning fuels that will enable meeting the performance goals of the Emission Control R and D for Advanced CIDI Engines and the Transportation Fuel Cell Power Systems Programs. The summaries cover the effects of CIDI engine emissions and fuel cell power system performance, the effects of lubricants on engine emissions, the effects of fuel and consumed lubricants on exhaust emission control devices and the health and safety, materials compatibility, and economics of advanced petroleum-based fuels.

Progression of 3D Protein Structure and Dynamics Measurements

Science.gov (United States)

Sato-Tomita, Ayana; Sekiguchi, Hiroshi; Sasaki, Yuji C.

2018-06-01

New measurement methodologies have begun to be proposed with the recent progress in the life sciences. Here, we introduce two new methodologies, X-ray fluorescence holography for protein structural analysis and diffracted X-ray tracking (DXT), to observe the dynamic behaviors of individual single molecules.

Fuel performance improvement program. Quarterly/annual progress report, October 1977--September 1978

International Nuclear Information System (INIS)

Crouthamel, C.E.

1978-10-01

This quarterly/annual report reviews and summarizes the activities performed in support of the Fuel Performance Improvement Program (FPIP) during Fiscal Year 1978 with emphasis on those activities that transpired during the quarter ending September 30, 1978. Significant progress has been made in achieving the primary objectives of the program, i.e., to demonstrate commercially viable fuel concepts with improved fuel - cladding interaction (FCI) behavior. This includes out-of-reactor experiments to support the fuel concepts being evaluated, initiation of instrumented test rod experiments in the Halden Boiling Water Reactor (HBWR), and fabrication of the first series of demonstration rods for irradiation in the Big Rock Point Reactor

Annual Progress report - General Task

International Nuclear Information System (INIS)

Wesnousky, S.G.

1993-01-01

This report provides a summary of progress for the project open-quotes Evaluation of the Geologic Relations and Seismotectonic Stability of the Yucca Mountain Area, Nevada Nuclear Waste Site Investigation (NNWSI).close quotes A similar report was previously provided for the period of 1 October 1991 to 30 September 1992. The report initially covers the activities of the General Task and is followed by sections that describe the progress of the other ongoing tasks

The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+ mouse.

Directory of Open Access Journals (Sweden)

James P White

Full Text Available Muscle wasting that occurs with cancer cachexia is caused by an imbalance in the rates of muscle protein synthesis and degradation. The Apc(Min/+ mouse is a model of colorectal cancer that develops cachexia that is dependent on circulating IL-6. However, the IL-6 regulation of muscle protein turnover during the initiation and progression of cachexia in the Apc(Min/+ mouse is not known. Cachexia progression was studied in Apc(Min/+ mice that were either weight stable (WS or had initial (≤5%, intermediate (6-19%, or extreme (≥20% body weight loss. The initiation of cachexia reduced %MPS 19% and a further ∼50% with additional weight loss. Muscle IGF-1 mRNA expression and mTOR targets were suppressed with the progression of body weight loss, while muscle AMPK phosphorylation (Thr 172, AMPK activity, and raptor phosphorylation (Ser 792 were not increased with the initiation of weight loss, but were induced as cachexia progressed. ATP dependent protein degradation increased during the initiation and progression of cachexia. However, ATP independent protein degradation was not increased until cachexia had progressed beyond the initial phase. IL-6 receptor antibody administration prevented body weight loss and suppressed muscle protein degradation, without any effect on muscle %MPS or IGF-1 associated signaling. In summary, the %MPS reduction during the initiation of cachexia is associated with IGF-1/mTOR signaling repression, while muscle AMPK activation and activation of ATP independent protein degradation occur later in the progression of cachexia. IL-6 receptor antibody treatment blocked cachexia progression through the suppression of muscle protein degradation, while not rescuing the suppression of muscle protein synthesis. Attenuation of IL-6 signaling was effective in blocking the progression of cachexia, but not sufficient to reverse the process.

The Regulation of Skeletal Muscle Protein Turnover during the Progression of Cancer Cachexia in the ApcMin/+ Mouse

Science.gov (United States)

White, James P.; Baynes, John W.; Welle, Stephen L.; Kostek, Matthew C.; Matesic, Lydia E.; Sato, Shuichi; Carson, James A.

2011-01-01

Muscle wasting that occurs with cancer cachexia is caused by an imbalance in the rates of muscle protein synthesis and degradation. The ApcMin/+ mouse is a model of colorectal cancer that develops cachexia that is dependent on circulating IL-6. However, the IL-6 regulation of muscle protein turnover during the initiation and progression of cachexia in the ApcMin/+ mouse is not known. Cachexia progression was studied in ApcMin/+ mice that were either weight stable (WS) or had initial (≤5%), intermediate (6–19%), or extreme (≥20%) body weight loss. The initiation of cachexia reduced %MPS 19% and a further ∼50% with additional weight loss. Muscle IGF-1 mRNA expression and mTOR targets were suppressed with the progression of body weight loss, while muscle AMPK phosphorylation (Thr 172), AMPK activity, and raptor phosphorylation (Ser 792) were not increased with the initiation of weight loss, but were induced as cachexia progressed. ATP dependent protein degradation increased during the initiation and progression of cachexia. However, ATP independent protein degradation was not increased until cachexia had progressed beyond the initial phase. IL-6 receptor antibody administration prevented body weight loss and suppressed muscle protein degradation, without any effect on muscle %MPS or IGF-1 associated signaling. In summary, the %MPS reduction during the initiation of cachexia is associated with IGF-1/mTOR signaling repression, while muscle AMPK activation and activation of ATP independent protein degradation occur later in the progression of cachexia. IL-6 receptor antibody treatment blocked cachexia progression through the suppression of muscle protein degradation, while not rescuing the suppression of muscle protein synthesis. Attenuation of IL-6 signaling was effective in blocking the progression of cachexia, but not sufficient to reverse the process. PMID:21949739

The effect of protein restriction on the progression of renal insufficiency

International Nuclear Information System (INIS)

Ihle, B.U.; Becker, G.J.; Whitworth, J.A.; Charlwood, R.A.; Kincaid-Smith, P.S.

1989-01-01

Dietary protein intake may be an important determinant of the rate of decline in renal function in patients with chronic renal insufficiency. We conducted a prospective, randomized study of the efficacy of protein restriction in slowing the rate of progression of renal impairment. The study lasted 18 months and included 64 patients with serum creatinine concentrations ranging from 350 to 1000 micromol per liter. The patients were randomly assigned to follow either a regular diet or an isocaloric protein-restricted diet (0.4 g of protein per kilogram of the body weight per day). Blood-pressure levels and the balance between calcium and phosphate were similar in the two groups. End-stage renal failure developed in 9 of the 33 patients (27 percent) who followed the regular diet during the study, as compared with 2 of the 31 patients (6 percent) who followed the protein-restricted diet (P less than 0.05). The mean (+/- SE) glomerular filtration rate, as measured by the clearance of 51Cr bound to EDTA, fell from 0.25 +/- 0.03 to 0.10 +/- 0.05 ml per second (P less than 0.01) in the group on the regular diet, whereas it fell from 0.23 +/- 0.04 to 0.20 +/- 0.05 ml per second (P not significant) in the group on the protein-restricted diet. We conclude that dietary protein restriction is effective in slowing the rate of progression of chronic renal failure

Mineral cycling in soil and litter arthropod food chains. Annual progress report, February 1, 1983-January 31, 1984

International Nuclear Information System (INIS)

Crossley, D.A. Jr.

1983-01-01

This annual report describes progress in research on the influence of soil fauna on the general process of terrestrial decomposition. The major goal is to investigate the regulation of decomposition by soil arthropods. Methods have included radioactive tracer measurements of food chain dynamics, rates of nutrient or mineral element flow during decomposition, and simulation modeling. This year's report describes significant progress in defining the influence of soil arthropods in stimulating microbial immobilization of nutrients. Preliminary efforts to define the importance of the soil-litter macroarthropods are also reported

Environmental Sciences Division annual progress report for period ending September 30, 1982. Environmental Sciences Division Publication No. 2090

International Nuclear Information System (INIS)

1983-04-01

Separate abstracts were prepared for 12 of the 14 sections of the Environmental Sciences Division annual progress report. The other 2 sections deal with educational activities. The programs discussed deal with advanced fuel energy, toxic substances, environmental impacts of various energy technologies, biomass, low-level radioactive waste management, the global carbon cycle, and aquatic and terrestrial ecology

Animal proteins in feed : annual report 2009-2010 of the Dutch National Reference Laboratory

NARCIS (Netherlands)

Raamsdonk, van L.W.D.; Scholtens-Toma, I.M.J.; Vliege, J.J.M.; Pinckaers, V.G.Z.; Groot, M.J.; Ossenkoppele, J.S.; Ruth, van S.M.

2011-01-01

RIKILT serves as the only official control laboratory for animal proteins in feeds in the Netherlands in the framework of Directive 882/2004/EC. As National Reference Laboratory (NRL), RIKILT participated in 2 annual proficiency tests during the reporting period, in 2 additional interlaboratory

Annual report on reactor safety research projects sponsored by the Ministry of Economics and Labour of the Federal Republic of Germany. Reporting period 2003. Progress report

International Nuclear Information System (INIS)

2003-01-01

The Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH, by order of the BMWi, continuously issues information on the status of the investigations into the safety of nuclear power plants by publishing semi-annual and annual progress reports within the series of GRS-F-Fortschrittsberichte (GRS-F-Progress Reports). Each progress report represents a compilation of individual reports about the objectives, work performed, results achieved, next steps of the work etc. The individual reports are prepared in a standard form by the research organisations themselves as documentation of their progress in work and are published by the Research Management Division of GRS within the framework of general information on the progress in reactor safety research. The compilation of the reports is classified according to general topics related to reactor safety research. Further, use is made of the classification system ''Joint Safety Research Index'' of the CEC (commission of the european communities). The reports are arranged in sequence of their project numbers

Annual report on reactor safety research projects sponsored by the Ministry for Research and Technology of the Federal Republic of Germany. Reporting period 1993. Progress report

International Nuclear Information System (INIS)

1994-10-01

The Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH, by order of the BMFT, informs continuously of the status of such investigations by means of semi-annual and annual publication of progress reports within the series GRS-F-Fortschrittsberichte (GRS-F-Progress Reports). Each progress report represents a compilation of individual reports about objectives, the work performed, the results, the next steps of the work etc. The individual reports are prepared in a standard form by the contractors themselves as a documentation of their progress in work and published by the Forschungsbetreuung at the GRS, (FB) (Research Coordination Department), within the framework of general information of progress in reactor safety research. The individual reports are classified according to the same classification system as applied in the nuclear index of the CEC (Commission of the European Communities) and the OECD (Organization for Economic Cooperation and Development). The reports are arranged in sequence of their project numbers. (orig./HP)

Chronic kidney disease progression: a retrospective analysis of 3-year adherence to a low protein diet.

Science.gov (United States)

Rizzetto, Felipe; Leal, Viviane de Oliveira; Bastos, Leonardo Soares; Fouque, Denis; Mafra, Denise

2017-11-01

The potential benefits and dangers of dietary protein restriction in chronic kidney disease (CKD) are still controversial. Thus, the aim of this study is to evaluate the effect of low protein diet (LPD) on the renal function in nondialysis CKD patients. A retrospective study was conducted from 321 nondialysis CKD patient's medical files (65.1 ± 12.7 yrs, 58.2% men). These patients received individualized dietary protein prescription (0.6-0.8 g protein/kg/day). Protein intake was evaluated by food diary and 24 h-food recall. Adherence to the LPD was considered when patients intake from 90 to 110% of the prescribed amount of protein. The patients were divided into 4 groups: (G1) adherent diabetes mellitus (DM) patients (n = 83); (G2) non-adherent DM patients (n = 106); (G3) adherent non-DM patients (n = 75); (G4) non-adherent non-DM patients (n = 57). Renal function was assessed by estimated glomerular filtration rate (eGFR). Both groups of patients (DM and non-DM) that adhered to the LPD showed significant improvement in eGFR (G1: 38.7 ± 13.2 mL/min to 51.1 ± 17.0 mL/min (p patients, no differences in albumin and BMI were observed at the end of follow up. In non-adherent patients, eGFR significantly decreased in DM group (G2: 44.2 ± 18.5 mL/min to 38.2 ± 15.8 mL/min (p = 0.003)). According to multivariate analysis, annual changes in eGFR were not independent associated with age, gender, BMI, lipid profile, bicarbonate or smoking status. In summary, adherence to low protein diet could be able to improve serum creatinine and eGFR, well-known markers of renal function. However, prospective studies are needed to control confounders which affect renal function and CKD progression.

[Research progress in hirudin fusion protein--review].

Science.gov (United States)

Zhang, Chuan-Ling; Yu, Ai-Ping; Jin, Ji-De; Wu, Chu-Tse

2007-02-01

Natural hirudin extracted from the secretion of medical leech salivary gland is a single-chain peptide containing 65 aminoacid residues with molecular weight of 7000 D, and exists in three isomers of HV1, HV2 and HV3. Hirudin possesses three disulfide bridges forming the structure of core cyclic peptides, which binds to the catalytic site of thrombin so as to inhibit the catalysis of thrombin. Its c-terminus rich in acidic aminoacid residues possesses hydrophilicity, and is free on the molecular surface, and can bind with fibrin recognition site of hirudin. The minimal segment of 12 - 16 C-terminal acidic residues keeps the minimal activity of anti-thrombosis. Thus, hirudin, as a potent and specific inhibitor of thrombin, can be used to protect from and to treat clinically thrombosis. As it has some disadvantages such as short half-life, bleeding side-effect and mono-function, and so on, hirudin has been fused with some other functional proteins in recent years. The obtained fusion proteins can prolong the half life of hirudin, or relieve it bleeding side effect, or bring new functions, such as thrombolysis, inhibiting the platelet aggregation, targeting specifically. The research progress in hirudin fusion protein was summarized in this review.

CEA Annual progress report 1986

International Nuclear Information System (INIS)

1987-01-01

This annual report presents the general organization of the CEA, the international relations and politics in nuclear field, the activities (military application, nuclear applied research, ANDRA (National Agency for Radioactive Waste Management), nuclear safety and protection, fundamental research, applied research other than nuclear), the industrial group; among topics about men and means, the budget execution of the public establishment of research. In annex, the nuclear power plants around the world and the principal legislative texts related to CEA or atomic energy published in 1986 [fr

Energy Division annual progress report for period ending September 30, 1988

International Nuclear Information System (INIS)

1989-06-01

The goals and accomplishments of the Energy Division of Oak Ridge National Laboratory are described in this annual progress report for Fiscal Year (FY) 1988. The Energy Division is a multidisciplinary research organization committed to (1) increasing the knowledge and understanding of the way society makes choices in energy use and energy-using technologies, (2) improving society's understanding of the environmental implications of changes in energy technology, and (3) improving and developing new energy-efficient technologies. The Energy Division's programmatic activities focus on four major areas: (1) analysis and assessment, (2) transportation and decision systems research, (3) technology research and development for improving the efficiency of energy and end-use technologies, and (4) electric power systems. The Division's total expenditures in FY 1988 were $44.3 million. The work is supported by the US Department of Energy, US Department of Defense, many other federal agencies, and some private organizations. Disciplines of the 139 staff members include engineering, social sciences, physical and life sciences, and mathematics and statistics

Development and application of the electrochemical etching technique. Annual progress report

Energy Technology Data Exchange (ETDEWEB)

1980-08-01

This annual progress report documents further advances in the development and application of electrochemical etching of polycarbonate foils (ECEPF) for fast, intermediate, and thermal neutron dosimetry as well as alpha particle dosimetry. The fast (> 1.1 MeV) and thermal neutron dosimetry techniques were applied to a thorough investigation of the neutron contamination inherent in and about the primary x-ray beam of several medical therapy electron accelerators. Because of the small size of ECEPF dosimeters in comparison to other neutron meters, they have an unusually low perturbation of the radiation field under measurement. Due to this small size and the increased sensitivity of the ECEPF dosimeter over current techniques of measuring neutrons in a high photon field, the fast neutron contamination in the primary x-ray beam of all the investigated accelerators was measured with precision and found to be greater than that suggested by the other, more common, neutron dosimetry methods.

Development and application of the electrochemical etching technique. Annual progress report

International Nuclear Information System (INIS)

1980-08-01

This annual progress report documents further advances in the development and application of electrochemical etching of polycarbonate foils (ECEPF) for fast, intermediate, and thermal neutron dosimetry as well as alpha particle dosimetry. The fast (> 1.1 MeV) and thermal neutron dosimetry techniques were applied to a thorough investigation of the neutron contamination inherent in and about the primary x-ray beam of several medical therapy electron accelerators. Because of the small size of ECEPF dosimeters in comparison to other neutron meters, they have an unusually low perturbation of the radiation field under measurement. Due to this small size and the increased sensitivity of the ECEPF dosimeter over current techniques of measuring neutrons in a high photon field, the fast neutron contamination in the primary x-ray beam of all the investigated accelerators was measured with precision and found to be greater than that suggested by the other, more common, neutron dosimetry methods

Subseabed disposal program annual report, January-December 1980. Volume II. Appendices (principal investigator progress reports). Part 1

International Nuclear Information System (INIS)

Hinga, K.R.

1981-07-01

Volume II of the sixth annual report describing the progress and evaluating the status of the Subseabed Disposal Program contains the appendices referred to in Volume I, Summary and Status. Because of the length of Volume II, it has been split into two parts for publication purposes. Part 1 contains Appendices A-Q; Part 2 contains Appendices R-MM. Separate abstracts have been prepared for each appendix for inclusion in the Energy Data Base

Subseabed disposal program annual report, January-December 1980. Volume II. Appendices (principal investigator progress reports). Part 1

Energy Technology Data Exchange (ETDEWEB)

Hinga, K.R. (ed.)

1981-07-01

Volume II of the sixth annual report describing the progress and evaluating the status of the Subseabed Disposal Program contains the appendices referred to in Volume I, Summary and Status. Because of the length of Volume II, it has been split into two parts for publication purposes. Part 1 contains Appendices A-Q; Part 2 contains Appendices R-MM. Separate abstracts have been prepared for each appendix for inclusion in the Energy Data Base.

Annual Report on Waste Generation and Waste Minimization Progress, 1991--1992

International Nuclear Information System (INIS)

1994-02-01

This report is DOE's first annual report on waste generation and waste minimization progress. Data presented in this report were collected from all DOE sites which met minimum threshold criteria established for this report. The fifty-seven site submittals contained herein represent data from over 100 reporting sites within 25 states. Radioactive, hazardous and sanitary waste quantities and the efforts to minimize these wastes are highlighted within the fifty-seven site submittals. In general, sites have made progress in moving beyond the planning phase of their waste minimization programs. This is evident by the overall 28 percent increase in the total amount of materials recycled from 1991 to 1992, as well as individual site initiatives. During 1991 and 1992, DOE generated a total of 279,000 cubic meters of radioactive waste and 243,000 metric tons of non-radioactive waste. These waste amounts include significant portions of process wastewater required to be reported to regulatory agencies in the state of Texas and the state of Tennessee. Specifically, the Pantex Plant in Texas treats an industrial wastewater that is considered by the Texas Water Commission to be a hazardous waste. In 1992, State regulated wastewater from the Pantex Plant represented 3,620 metric tons, 10 percent of the total hazardous waste generated by DOE. Similarly, mixed low-level wastewater from the TSCA Incinerator Facility at the Oak Ridge K-25 Site in Tennessee represented 55 percent of the total radioactive waste generated by DOE in 1992

Annual Report on Waste Generation and Waste Minimization Progress, 1991--1992

Energy Technology Data Exchange (ETDEWEB)

1994-02-01

This report is DOE`s first annual report on waste generation and waste minimization progress. Data presented in this report were collected from all DOE sites which met minimum threshold criteria established for this report. The fifty-seven site submittals contained herein represent data from over 100 reporting sites within 25 states. Radioactive, hazardous and sanitary waste quantities and the efforts to minimize these wastes are highlighted within the fifty-seven site submittals. In general, sites have made progress in moving beyond the planning phase of their waste minimization programs. This is evident by the overall 28 percent increase in the total amount of materials recycled from 1991 to 1992, as well as individual site initiatives. During 1991 and 1992, DOE generated a total of 279,000 cubic meters of radioactive waste and 243,000 metric tons of non-radioactive waste. These waste amounts include significant portions of process wastewater required to be reported to regulatory agencies in the state of Texas and the state of Tennessee. Specifically, the Pantex Plant in Texas treats an industrial wastewater that is considered by the Texas Water Commission to be a hazardous waste. In 1992, State regulated wastewater from the Pantex Plant represented 3,620 metric tons, 10 percent of the total hazardous waste generated by DOE. Similarly, mixed low-level wastewater from the TSCA Incinerator Facility at the Oak Ridge K-25 Site in Tennessee represented 55 percent of the total radioactive waste generated by DOE in 1992.

Twenty-ninth annual progress report of the Pennsylvania State University Breazeale Nuclear Reactor, July 1, 1983-June 30, 1984

International Nuclear Information System (INIS)

Levine, S.H.; Totenbier, R.E.

1984-07-01

The twenty-ninth annual progress report of the operation of the Pennsylvania State University Breazeale Reactor is submitted in accordance with the requirements of Contract DE-AC02-76ER03409 with the United States Department of Energy. This report also provides the University administration with a summary of the operation of the facility for the past year

Progress Report

Science.gov (United States)

2018-05-16

This report summarizes the annual progress of EPA’s Clean Air Markets Programs such as the Acid Rain Program (ARP) and the Cross-State Air Pollution Rule (CSAPR). EPA systematically collects data on emissions, compliance, and environmental effects, these data are highlighted in our Progress Reports.

Detection and quantification of proteins and cells by use of elemental mass spectrometry: progress and challenges.

Science.gov (United States)

Yan, Xiaowen; Yang, Limin; Wang, Qiuquan

2013-07-01

Much progress has been made in identification of the proteins in proteomes, and quantification of these proteins has attracted much interest. In addition to popular tandem mass spectrometric methods based on soft ionization, inductively coupled plasma mass spectrometry (ICPMS), a typical example of mass spectrometry based on hard ionization, usually used for analysis of elements, has unique advantages in absolute quantification of proteins by determination of an element with a definite stoichiometry in a protein or attached to the protein. In this Trends article, we briefly describe state-of-the-art ICPMS-based methods for quantification of proteins, emphasizing protein-labeling and element-tagging strategies developed on the basis of chemically selective reactions and/or biospecific interactions. Recent progress from protein to cell quantification by use of ICPMS is also discussed, and the possibilities and challenges of ICPMS-based protein quantification for universal, selective, or targeted quantification of proteins and cells in a biological sample are also discussed critically. We believe ICPMS-based protein quantification will become ever more important in targeted quantitative proteomics and bioanalysis in the near future.

Rho proteins − the key regulators of cytoskeleton in the progression of mitosis and cytokinesis

Directory of Open Access Journals (Sweden)

Anna Klimaszewska

2011-11-01

Full Text Available The Rho proteins are members of the Ras superfamily of small GTPases. They are thought to be crucial regulators of multiple signal transduction pathways that influence a wide range of cellular functions, including migration, membrane trafficking, adhesion, polarity and cell shape changes. Thanks to their ability to control the assembly and organization of the actin and microtubule cytoskeletons, Rho GTPases are known to regulate mitosis and cytokinesis progression. These proteins are required for formation and rigidity of the cortex during mitotic cell rounding, mitotic spindle formation and attachment of the spindle microtubules to the kinetochore. In addition, during cytokinesis, they are involved in promoting division plane determination, contractile ring and cleavage furrow formation and abscission. They are also known as regulators of cell cycle progression at the G1/S and G2/M transition. Thus, the signal transduction pathways in which Rho proteins participate, appear to connect dynamics of actin and microtubule cytoskeletons to cell cycle progression. We review the current state of knowledge concerning the molecular mechanisms by which Rho GTPase signaling regulates remodeling of actin and microtubule cytoskeletons in order to control cell division progression.

Identification of differentially expressed proteins during human urinary bladder cancer progression.

Science.gov (United States)

Memon, Ashfaque A; Chang, Jong W; Oh, Bong R; Yoo, Yung J

2005-01-01

Comparative proteome analysis was performed between RT4 (grade-1) and T24 (grade-3) bladder cancer cell lines, in an attempt to identify differentially expressed proteins during bladder cancer progression. Among those relatively abundant proteins, seven spots changed more than two-fold reproducibly and identified by peptide mass fingerprinting using mass spectrometry and database search. We found most extensive and reproducible down-regulation of NADP dependent isocitrate dehydrogenase cytoplasmic (IDPc) and peroxiredoxin-II (Prx-II), in poorly differentiated T24 compared to well-differentiated RT4 bladder cancer cell line. Subsequent Western blotting analysis of human biopsy samples from bladder cancer patient revealed significant loss of IDPc and Prx-II in more advance tumor samples, in agreement with data on cell lines. These results suggest that loss of IDPc and Prx-II during tumor development may involve in tumor progression and metastasis. However, additional investigations are needed on large number of human samples to further verify these findings.

Annual progress report 1980

International Nuclear Information System (INIS)

1981-01-01

The technical support activities of the IPSN to competent administrations in 1980 has been marked: namely by the authorizations of divergence for 9 units EdF-PWR of 900 MW, the authorization project of creation and extension of reprocessing plant of COGEMA at the Hague UP 2 -800 and the authorization of starting up of the third unit of production of the EURODIF enrichment plant at Tricastin. On the other hand, IPSN has participated at the elaboration of a certain number of legislative and regulation texts relative to the control of nuclear matter, to radioprotection standards and to criteria of safety. For the safety of breeder, the test made at CABRI pile, in the international research program has given confirmation of the validity of theoretical models used in accidents calculations, hypothetical accidents which has allowed to reactualize safety criteria which have to be used for the development of this type of reactor. In worker radioprotection the results obtained in laboratory on the effect of radon, the progress made in personal dosimetry and the action of radioprotection undertaken in uranium mines constitutes a coherent effort. The deep drilling in granit (1000 m) and the experimental associated program which has finished the indispensable scientific data for the future policy in matter of storage of radioactives wastes. IPSN has contributed to progress made in the rules of exploitation of reactors, in the definition of wastes containment -specially at the output of reprocessing plant- in handling machines in hazardeous areas and in the study of environment [fr

[Progress in the spectral library based protein identification strategy].

Science.gov (United States)

Yu, Derui; Ma, Jie; Xie, Zengyan; Bai, Mingze; Zhu, Yunping; Shu, Kunxian

2018-04-25

Exponential growth of the mass spectrometry (MS) data is exhibited when the mass spectrometry-based proteomics has been developing rapidly. It is a great challenge to develop some quick, accurate and repeatable methods to identify peptides and proteins. Nowadays, the spectral library searching has become a mature strategy for tandem mass spectra based proteins identification in proteomics, which searches the experiment spectra against a collection of confidently identified MS/MS spectra that have been observed previously, and fully utilizes the abundance in the spectrum, peaks from non-canonical fragment ions, and other features. This review provides an overview of the implement of spectral library search strategy, and two key steps, spectral library construction and spectral library searching comprehensively, and discusses the progress and challenge of the library search strategy.

Environmental Sciences Division annual progress report for period ending September 30, 1982. Environmental Sciences Division Publication No. 2090. [Lead abstract

Energy Technology Data Exchange (ETDEWEB)

1983-04-01

Separate abstracts were prepared for 12 of the 14 sections of the Environmental Sciences Division annual progress report. The other 2 sections deal with educational activities. The programs discussed deal with advanced fuel energy, toxic substances, environmental impacts of various energy technologies, biomass, low-level radioactive waste management, the global carbon cycle, and aquatic and terrestrial ecology. (KRM)

Clinical Investigation Program Annual Progress Report

Science.gov (United States)

1988-10-20

Presented: Interna- tional Symposium on Orthopedics, Mexico , September 1987. Publications: In preparation. 147 FAMC A.P.R. (RCS MED 300) Detail Summary...Infection: A Prospective Study. Presented: 2nd Annual Symposium of the Rocky Moun- tain Flow Cytometry Users Group, Albuquerque, New Mexico , 10-11...Podgore, COL, MC (9) Dept/ISvc: Pediatrics (10) Associate Investigators (11) Key Words: Myron J. Levin, M.D. varicella vaccine U Co. HSC (12

[Retrospective analysis of influence of differential protein intake on renal prognosis for progressive chronic kidney disease].

Science.gov (United States)

Dai, Wendi; Yin, Daoxin; Cui, Wenying; Liu, Wenhu

2014-01-28

To explore retrospectively the influence of differential protein intake on renal prognosis for progressive chronic kidney disease (CKD). A total of 159 chronic kidney disease patients at stages 2, 3 and 4 were enrolled and a questionnaire survey was conducted from January 2009 to July 2012. They were followed monthly and their clinical data collected, including primary disease, blood pressure, body mass index and adverse events. Laboratory tests were performed every 3 months, including biochemical parameters, protein-energy malnutrition (PEM), diet reviews and daily protein intake (DPI). A simplified MDRD formula was employed to evaluate the level of estimated glomerular filtration rate (eGFR). According to the level of DPI, they were divided into 3 groups of very low protein diet (VLPD): DPI ≤ 0.6 g · kg(-1) · d(-1), low-protein diet (LPD): DPI >0.6-protein diet (NPD): DPI ≥ 0.8 · g · kg(-1) · d(-1). Among them, 4 cases (2.50%) progressed to uremia stage and received renal replacement therapy, 2(1.25%) experienced rapid decline in renal function, 9(5.66%) were hospitalized from cardio-cerebral diseases and the 2-year kidney survival rate was 97.5%. At the end of study, among 9 patients of PEM, 2 subjects had a serum level of albumin under 32 g/L and another 7 with a BMI 0.05). Within a certain range, differential protein intake may not significantly affect the prognosis of kidney for progressive CKD patients.

Annual Research Progress Report, Fiscal Year 1979,

Science.gov (United States)

1979-10-01

nasopharyngeal angiofibroma : A case report. 63rd Annual Clinical Assembly The Osteopathic College of Ophthalmology and Otolaryngology, May 1979, Sulphur Springs...Combined surgical management of a juvenile nasopharyngeal angiofibroma : A case report. The Laryngoscope. Perry, F.P. Hyperbaric oxygen in the treatment of

Urine liver fatty acid binding protein and chronic kidney disease progression

DEFF Research Database (Denmark)

Khatir, Dinah S; Bendtsen, Mette D; Birn, Henrik

2017-01-01

, regarding progression of chronic kidney disease (CKD). In a prospective study design a cohort of 74 stage 3-4 CKD patients (age 61 ± 13 years) were included. Glomerular filtration ratio (GFR, 51Cr-EDTA-clearance), 24-hour ambulatory BP, 24-hour urinary albumin/creatinine ratio (UAC) and urinary L......Excretion of the tubular protein liver fatty acid binding protein (L-FABP) is a potential novel biomarker of renal dysfunction. We examined whether urine L-FABP excretion adds prognostic information to the well-established risk markers, blood pressure (BP), albumin excretion and baseline GFR...

Annual progress report FY 1977

International Nuclear Information System (INIS)

Hansen, K.F.; Henry, A.F.

1977-07-01

Progress is summarized in a project directed toward development of numerical methods suitable for the computer solution of problems in reactor dynamics and safety. Specific areas of research include methods of integration of the time-dependent diffusion equations by finite difference and finite element methods; representation of reactor properties by various homogenization procedures; application of synthesis methods; and development of response matrix techniques

Research in theoretical elementary particle physics at the University of Florida: Task A. Annual progress report

International Nuclear Information System (INIS)

Field, R.D.; Ramond, P.M.; Sikivie, P.; Thorn, C.B.

1994-01-01

This is the Annual Progress Report of the theoretical particle theory group at the University of Florida under DOE Grant DE-FG05-86ER40272. At present our group consists of four Full Professors (Field, Ramond, Thorn, Sikivie), one Associate Professor (Woodard), and two Assistant Professors (Qiu, Kennedy). In addition, we have four postdoctoral research associates and seven graduate students. The research of our group covers a broad range of topics in theoretical high energy physics including both theory and phenomenology. Included in this report is a summary of the last several years, an outline of our current research program

Annual Program Progress Report under DOE/PHRI Cooperative Agreement: (July 1, 2001-June 30, 2002)

Energy Technology Data Exchange (ETDEWEB)

Palafox, Neal A., MD, MPH

2002-07-31

OAK B188 DOE/PHRI Special Medical Care Program in the Republic of the Marshall Islands (RMI)Annual Program Progress Report. The DOE Marshall Islands Medical Program continued, in this it's 48th year, to provide medical surveillance for the exposed population from Rongelap and Utrik and the additional DOE patients. The program was inaugurated in 1954 by the Atomic Energy Commission following the exposure of Marshallese to fallout from a nuclear test (Castle Bravo) at Bikini Atoll. This year marks the fourth year in which the program has been carried out by PHRI under a cooperative agreement with DOE. The DOERHRI Special Medical Care Program, awarded the cooperative agreement on August 28, 1998, commenced its health care program on January 15, 1999, on Kwajalein and January 22, 1999, on Majuro. This report details the program for the July 1, 2001, through the June 30, 2002, period. The program provides year-round, on-site medical care to the DOE patient population residing in the Republic of the Marshall Islands (RMI) and annual examinations to those patients living in Hawaii and on the Continental U.S.

1985. Progress annual report

International Nuclear Information System (INIS)

1986-06-01

Tore Supra construction has been vigorously continued. The whole cryogenic system has been entirely delivered. On TFR priority has been given to electron cyclotron resonance heating; but also neutral heating mechanisms, pellet injection, plasma-wall interaction in the presence of pumped limiter, impurity transport and plasma turbulence have been studied and progress on diagnostics have been made. On Petula, with lower hybrid wave, the numerous results on ion heating, current drive, plasma stability in the presence of non-inductive current and on Tore Supra technical problems are important. At last, theoretical and numerical results are concerned with plasma equilibrium macroscopic evolution of plasma, RF heating, plasma instabilities, magnetic islands, turbulence, transport coefficients and spectroscopy [fr

Chemical and biological nonproliferation program. FY99 annual report; ANNUAL

International Nuclear Information System (INIS)

NONE

2000-01-01

This document is the first of what will become an annual report documenting the progress made by the Chemical and Biological Nonproliferation Program (CBNP). It is intended to be a summary of the program's activities that will be of interest to both policy and technical audiences. This report and the annual CBNP Summer Review Meeting are important vehicles for communication with the broader chemical and biological defense and nonproliferation communities. The Chemical and Biological Nonproliferation Program Strategic Plan is also available and provides additional detail on the program's context and goals. The body of the report consists of an overview of the program's philosophy, goals and recent progress in the major program areas. In addition, an appendix is provided with more detailed project summaries that will be of interest to the technical community

Annual report 2009-10

International Nuclear Information System (INIS)

2009-01-01

The annual progress for the year 2009-10 for Pakistan Atomic Energy Commission (PAEC) is presented. The progress of various Center and their contribution for the uplift of nuclear programme have been described. The progress report fully explained under various topics as under: Highlights, Nuclear Power, Engineering, Physical Sciences, Biological Sciences, Nuclear Materials, Safety, Quality, Human Resource Development, PAEC General Health Services, Projects / International Collaboratioin and publications. (A.B.)

Annual report on Reactor Safety Research Projects sponsored by the Ministry of Economics and Technology of the Federal Republic of Germany. Reporting period 1999. Progress report

International Nuclear Information System (INIS)

2000-01-01

Within its competence for energy research, the Bundesministerium fuer Wirtschaft und Technologie (BMWi) (Federal Ministry of Economics and Technology) sponsors investigations into the safety of nuclear power plants. The objective of these investigations is to provide fundamental knowledge, procedures and methods to contribute to realistic safety assessments of nuclear installations, to the further development of safety technology and to make use of the potential of innovative safety-related approaches. The Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH, by order of the BMWi, continuously issues information on the status of such investigations by publishing semi-annual and annual progress reports within the series of GRS-F-Fortschrittsberichte (GRS-F-Progress Reports). Each progress report represents a compilation of individual reports about the objectives, work performed, results achieved, next steps of the work etc. The individual reports are prepared in a standard form by the research organisations themselves as documentation of their progress in work and are published by the Research Management Division of GRS within the framework of general information on the progress in reactor safety research. The compilation of the reports is classified according to the classification system ''Joint Safety Research Index'' of the CEC (commission of the European communities). The reports are arranged in sequence of their project numbers. (orig.)

Magnetic fusion energy materials technology program annual progress report for period ending June 30, 1977

International Nuclear Information System (INIS)

Scott, J.L.

1977-09-01

The objectives of the Magnetic Fusion Energy (MFE) Materials Technology Program, which is described in this report, are to continue to solve the materials problems of the Fusion Energy Division of ORNL and to meet needs of the national MFE program, directed by the ERDA Division of Magnetic Fusion Energy (DMFE). This work is a continuation of the program described in previous annual progress reports. The principal areas of work include radiation effects, compatibility studies, materials studies related to the plasma-materials interaction, materials engineering, radiation behavior of superconducting magnet insulation, and mechanical properties of superconducting composites. The level of effort and schedules are consistent with Logic II of the DMFE Program Plan

Subseabed disposal program annual report, January-December 1979. Volume II. Appendices (principal investigator progress reports). Part 1 of 2

International Nuclear Information System (INIS)

Talbert, D.M.

1981-04-01

Volume II of the sixth annual report describing the progress and evaluating the status of the Subseabed Disposal Program contains the appendices referred to in Volume I, Summary and Status. Because of the length of Volume II, it has been split into two parts for publication purposes. Part 1 contains Appendices A-O; Part 2 contains Appendices P-FF. Separate abstracts have been prepared of each Appendix for inclusion in the Energy Data Base

Subseabed disposal program annual report, January-December 1979. Volume II. Appendices (principal investigator progress reports). Part 2 of 2

International Nuclear Information System (INIS)

Talbert, D.M.

1981-04-01

Volume II of the sixth annual report describing the progress and evaluating the status of the Subseabed Disposal Program contains the appendices referred to in Volume II, Summary and Status. Because of the length of Volume II, it has been split into two parts for publication purposes. Part 1 contains Appendices A-O; Part 2 contains Appendices P-FF. Separate abstracts have been prepared for each appendix for inclusion in the Energy Data Base

CTR plasma engineering studies. Annual progress report, 1 December 1984-30 November 1985

International Nuclear Information System (INIS)

Miley, G.H.

1985-01-01

Work under this project is focused on plasma engineering developments in support of fusion reactor studies. The work described in this annual progress report covers a variety of topics ranging from plasma transport modelling for compact tori to radiation heating of the first wall in a fusion device. Sections 2 and 3 decribe computer codes developed for use with field-reversed configurations such as spheromaks and field-reversed mirrors. Section 4 presents an evaluation of the feasibility of heating a RFP-type reactor to ignition with ohmic current input alone. Sections 5 and 6 describe new work that has been initiated on optimal control theory for fusion reactors. Sections 7 to 9 discuss recent results on alpha-particle transport, instabilities, and diagnostics. In the final section, methods for analysis of the poloidal variation in the thermal wall loading of a tokamak reactor are discussed and some typical results are presented

1983. Annual progress report

International Nuclear Information System (INIS)

1984-01-01

A beautiful experiment series for studying high energy excitation structures (10 to 80 MeV), concerning very heavy and asymmetric systems. CEV-Alice contributions to annual report concern Hg and Er high spin energy levels. About reaction mechanisms, the following contributions can be noticed: proton backward emission experiment results of high energy, at 200 MeV, on numerous targets; spectroscopic studies of direct transfer reactions by 18 O with measurement of angular distributions until 0 0 ; many heavy ion experiments around 30 MeV/u concerning the mechanism evolution between 10 and 100 MeV. Pion coherent production experiments have been made this year on energy dependence of the reaction 3 He+ 3 He → 6 Li+π + , considered as an existing model test. Cross section measurement of the elementary reactions (p,π + ) on three targets of very different masses, in a large energy scale and a wide angular domain, have been measured at the Synchrocyclotron. Concerning the nuclear structure in low and medium energy levels, elastic scattering and transfer studies are to be noticed particularly in transition nuclei region. Exotic nuclei rich in neutrons, with medium mass, Fe, Co, Ni, Zn have been studied using the 14 C beam of the Orsay tandem. The radiochemistry group work is essentially centered on actinides study [fr

Expression of XPG protein in the development, progression and prognosis of gastric cancer.

Directory of Open Access Journals (Sweden)

Na Deng

Full Text Available BACKGROUND: Xeroderma pigmentosum group G (XPG plays a critical role in preventing cells from oxidative DNA damage. This study aimed to investigate XPG protein expression in different gastric tissues and in patients with diverse prognoses, thus providing insights into its role in the development, progression and prognosis of gastric cancer (GC. METHODS: A total of 176 GC, 131 adjacent non-tumour tissues, 53 atrophic gastritis (AG and 49 superficial gastritis (SG samples were included. Immunohistochemical staining was used to detect XPG protein expression. RESULTS: XPG expression was significantly higher in GC tissues compared with adjacent non-tumour tissues. In the progressive disease sequence SG→AG→GC, XPG expression was significantly higher in AG and GC compared with SG. Analysis of clinicopathological parameters and survival in GC patients demonstrated a significant association between XPG expression level and depth of tumour invasion, macroscopic type, Lauren's classification, smoking, Helicobacter pylori infection and family history. Cox multivariate survival analysis indicated that patients with positive XPG expression had significantly longer overall survival (P = 0.020, HR = 0.394, 95%CI 0.179-0.866, especially in aged younger than 60 years (P = 0.027, HR = 0.361, 95%CI 0.147-0.888 and male patients (P = 0.002, HR = 0.209, 95%CI 0.077-0.571. CONCLUSIONS: This study demonstrated that XPG protein expression was related to the development, progression and prognosis of GC, and might thus serve as a potential biomarker for its diagnosis and prognosis.

Clinical Investigation Program Annual Progress Report

Science.gov (United States)

1989-10-01

Meeting, Washington DC, September 1989 Parsons MK: Acute Shift of Right Ventricular Distensibility After Balloon Pulmonary Vavuloplasty. American Heart...selected range of motion using both concentric and eccentric muscular contractions. PROGRESS: No. of Subjects Enrolled - To Date: 8 Reporting Period: 8 1

Exogenous fatty acid binding protein 4 promotes human prostate cancer cell progression.

Science.gov (United States)

Uehara, Hisanori; Takahashi, Tetsuyuki; Oha, Mina; Ogawa, Hirohisa; Izumi, Keisuke

2014-12-01

Epidemiologic studies have found that obesity is associated with malignant grade and mortality in prostate cancer. Several adipokines have been implicated as putative mediating factors between obesity and prostate cancer. Fatty acid binding protein 4 (FABP4), a member of the cytoplasmic fatty acid binding protein multigene family, was recently identified as a novel adipokine. Although FABP4 is released from adipocytes and mean circulating concentrations of FABP4 are linked with obesity, effects of exogenous FABP4 on prostate cancer progression are unclear. In this study, we examined the effects of exogenous FABP4 on human prostate cancer cell progression. FABP4 treatment promoted serum-induced prostate cancer cell invasion in vitro. Furthermore, oleic acid promoted prostate cancer cell invasion only if FABP4 was present in the medium. These promoting effects were reduced by FABP4 inhibitor, which inhibits FABP4 binding to fatty acids. Immunostaining for FABP4 showed that exogenous FABP4 was taken up into DU145 cells in three-dimensional culture. In mice, treatment with FABP4 inhibitor reduced the subcutaneous growth and lung metastasis of prostate cancer cells. Immunohistochemical analysis showed that the number of apoptotic cells, positive for cleaved caspase-3 and cleaved PARP, was increased in subcutaneous tumors of FABP4 inhibitor-treated mice, as compared with control mice. These results suggest that exogenous FABP4 might promote human prostate cancer cell progression by binding with fatty acids. Additionally, exogenous FABP4 activated the PI3K/Akt pathway, independently of binding to fatty acids. Thus, FABP4 might be a key molecule to understand the mechanisms underlying the obesity-prostate cancer progression link. © 2014 UICC.

CTR plasma engineering studies. Annual progress report, 1 December 1985-30 November 1986

International Nuclear Information System (INIS)

Miley, G.H.

1986-01-01

The work described in this annual progress report covers a variety of topics ranging from alpha instabilities and current drive techniques to radiation heating of the first wall in a fusion device. Section II discusses work carried out on alpha instabilities, including comments on problems anticipated in the proposed compact ignition experiment and also recent studies of effects in tandem mirrors. Sections III and IV describe our recent efforts on RFP modelling. This includes a detailed study of oscillating field current drive (F-Θ) pumping and also parametric studies of ignition requirements. Section V presents a report of our application of control theory techniques to the stabilization of an elongated tokamak (ET) using feedback control of the plasma elongation. Section VI discusses our most recent study of the first-wall thermal response to plasma energy deposition while Section VII reviews our continuing study of techniques to radiation harden a wall detector for measuring alpha distributions in a burning plasma

Protein Oxidation in Aging: Does It Play a Role in Aging Progression?

Science.gov (United States)

Reeg, Sandra

2015-01-01

Abstract Significance: A constant accumulation of oxidized proteins takes place during aging. Oxidation of proteins leads to a partial unfolding and, therefore, to aggregation. Protein aggregates impair the activity of cellular proteolytic systems (proteasomes, lysosomes), resulting in further accumulation of oxidized proteins. In addition, the accumulation of highly crosslinked protein aggregates leads to further oxidant formation, damage to macromolecules, and, finally, to apoptotic cell death. Furthermore, protein oxidation seems to play a role in the development of various age-related diseases, for example, neurodegenerative diseases. Recent Advances: The highly oxidized lipofuscin accumulates during aging. Lipofuscin formation might cause impaired lysosomal and proteasomal degradation, metal ion accumulation, increased reactive oxygen species formation, and apoptosis. Critical Issues: It is still unclear to which extent protein oxidation is involved in the progression of aging and in the development of some age-related diseases. Future Directions: An extensive knowledge of the effects of protein oxidation on the aging process and its contribution to the development of age-related diseases could enable further strategies to reduce age-related impairments. Strategies aimed at lowering aggregate formation might be a straightforward intervention to reduce age-related malfunctions of organs. Antioxid. Redox Signal. 23, 239–255. PMID:25178482

2. Semi-annual progress report 1980, no 17

International Nuclear Information System (INIS)

1981-01-01

This semi-annual report deals with the experimental research carried out at the Departement de Recherche Fondamentale de Grenoble (fission, nuclear spectroscopy, heavy ion reactions, physical metallurgy, magnetism, organic molecules, theoretical chemistry, molecular physical chemistry, cellular biology, vegetal biology) [fr

Neutron scattering. Annual progress report 1997; Neutronenstreuung. Annual progress report 1997

Energy Technology Data Exchange (ETDEWEB)

Allenspach, P.; Boeni, B.; Fischer, P.; Furrer, A. [Eidgenoessische Technische Hochschule, Zurich (Switzerland). Lab. fuer Neutronenstreuung

1998-02-01

The present progress report describes the scientific and technical activities obtained by LNS staff members in 1997. It also includes the work performed by external groups at our CRG instruments D1A and IN3 at the ILL Grenoble. Due to the outstanding properties of neutrons and x-rays the research work covered many areas of science and materials research. The highlight of the year 1997 was certainly the production of neutrons at the new spallation neutron source SINQ. From July to November, SINQ was operating for typically two days/week and allowed the commissioning of four instruments at the neutron guide system: - the triple-axis spectrometer Druechal, - the powder diffractometer DMC, - the double-axis diffractometer TOPSI, the polarised triple-axis spectrometer TASP. These instruments are now fully operational and have already been used for condensed matter studies, partly in cooperation with external groups. Five further instruments are in an advanced state, and their commissioning is expected to occur between June and October 1998: - the high-resolution powder diffractometer HRPT, - the single-crystal diffractometer TriCS, - the time-of-flight spectrometer FOCUS, - the reflectometer AMOR, - the neutron optical bench NOB. Together with the small angle neutron scattering facility SANS operated by the spallation source department, all these instruments will be made available to external user groups in the future. (author) figs., tabs., refs.

Progress report on nuclear science and technology in China (Vol.1). Proceedings of academic annual meeting of China Nuclear Society in 2009, No.5

International Nuclear Information System (INIS)

2010-11-01

Progress report on nuclear science and technology in China (Vol. 1) includes 889 articles which are communicated on the first national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the fifth one, the content is about radiation protection and nuclear chemical industry.

Energy Division annual progress report for period ending September 30, 1991

Energy Technology Data Exchange (ETDEWEB)

Stone, J.N. (ed.)

1992-04-01

The Energy Division is one of 17 research divisions at Oak Ridge Laboratory. Its goals and accomplishments are described in this annual progress report for FY 1991. The division's total expenditures in FY 1991 were $39.1 million. The work is supported by the US Department of Energy, US Department of Defense, many other federal agencies, and some private organizations. Disciplines of the 124 technical staff members include engineering, social sciences, physical and life sciences, and mathematics and statistics. The Energy Division's programmatic activities focus on three major areas: (1) analysis and assessment, (2) energy conservation technologies, and (3) military transportation systems. Analysis and assessment activities cover energy and resource analysis, the preparation of environmental assessments and impact statements, research on waste management, analysis of emergency preparedness for natural and technological disasters, analysis of the energy and environmental needs of developing countries, technology transfer, and analysis of civilian transportation. Energy conservation technologies include electric power systems, building equipment (thermally activated heat pumps, advanced refrigeration systems, novel cycles), building envelopes (walls, foundations, roofs, attics, and materials), and technical issues for improving energy efficiency in existing buildings. Military transportation systems concentrate on research for sponsors within the US military on improving the efficiency of military deployment, scheduling, and transportation coordination.

Energy Division annual progress report for period ending September 30, 1991

Energy Technology Data Exchange (ETDEWEB)

Stone, J.N. [ed.

1992-04-01

The Energy Division is one of 17 research divisions at Oak Ridge Laboratory. Its goals and accomplishments are described in this annual progress report for FY 1991. The division`s total expenditures in FY 1991 were $39.1 million. The work is supported by the US Department of Energy, US Department of Defense, many other federal agencies, and some private organizations. Disciplines of the 124 technical staff members include engineering, social sciences, physical and life sciences, and mathematics and statistics. The Energy Division`s programmatic activities focus on three major areas: (1) analysis and assessment, (2) energy conservation technologies, and (3) military transportation systems. Analysis and assessment activities cover energy and resource analysis, the preparation of environmental assessments and impact statements, research on waste management, analysis of emergency preparedness for natural and technological disasters, analysis of the energy and environmental needs of developing countries, technology transfer, and analysis of civilian transportation. Energy conservation technologies include electric power systems, building equipment (thermally activated heat pumps, advanced refrigeration systems, novel cycles), building envelopes (walls, foundations, roofs, attics, and materials), and technical issues for improving energy efficiency in existing buildings. Military transportation systems concentrate on research for sponsors within the US military on improving the efficiency of military deployment, scheduling, and transportation coordination.

Fusion Energy Division annual progress report, period ending December 31, 1989

Energy Technology Data Exchange (ETDEWEB)

Sheffield, J.; Baker, C.C.; Saltmarsh, M.J.

1991-07-01

The Fusion Program of Oak Ridge National Laboratory (ORNL) carries out research in most areas of magnetic confinement fusion. The program is directed toward the development of fusion as an energy source and is a strong and vital component of both the US fusion program and the international fusion community. Issued as the annual progress report of the ORNL Fusion Energy Division, this report also contains information from components of the Fusion Program that are carried out by other ORNL organizations (about 15% of the program effort). The areas addressed by the Fusion Program and discussed in this report include the following: Experimental and theoretical research on magnetic confinement concepts, engineering and physics of existing and planned devices, including remote handling, development and testing of diagnostic tools and techniques in support of experiments, assembly and distribution to the fusion community of databases on atomic physics and radiation effects, development and testing of technologies for heating and fueling fusion plasmas, development and testing of superconducting magnets for containing fusion plasmas, development and testing of materials for fusion devices, and exploration of opportunities to apply the unique skills, technology, and techniques developed in the course of this work to other areas. Highlights from program activities are included in this report.

Fusion Energy Division: Annual progress report, period ending December 31, 1987

Energy Technology Data Exchange (ETDEWEB)

Morgan, O.B. Jr.; Berry, L.A.; Sheffield, J.

1988-11-01

The Fusion Program of Oak Ridge National Laboratory (ORNL), a major part of the national fusion program, carries out research in nearly all areas of magnetic fusion. Collaboration among staff from ORNL, Martin Marietta Energy Systems, Inc., private industry, the academic community, and other fusion laboratories, in the United States and abroad, is directed toward the development of fusion as an energy source. This report documents the program's achievements during 1987. Issued as the annual progress report of the ORNL Fusion Energy Division, it also contains information from components of the Fusion Program that are external to the division (about 15% of the program effort). The areas addressed by the Fusion Program include the following: experimental and theoretical research on magnetic confinement concepts, engineering and physics of existing and planned devices, development and testing of diagnostic tools and techniques in support of experiments, assembly and distribution to the fusion community of databases on atomic physics and radiation effects, development and testing of technologies for heating and fueling fusion plasmas, development and testing of superconducting magnets for containing fusion plasmas, and development and testing of materials for fusion devices. Highlights from program activities are included in this report. 126 figs., 15 tabs.

Fusion Energy Division annual progress report, period ending December 31, 1989

International Nuclear Information System (INIS)

Sheffield, J.; Baker, C.C.; Saltmarsh, M.J.

1991-07-01

The Fusion Program of Oak Ridge National Laboratory (ORNL) carries out research in most areas of magnetic confinement fusion. The program is directed toward the development of fusion as an energy source and is a strong and vital component of both the US fusion program and the international fusion community. Issued as the annual progress report of the ORNL Fusion Energy Division, this report also contains information from components of the Fusion Program that are carried out by other ORNL organizations (about 15% of the program effort). The areas addressed by the Fusion Program and discussed in this report include the following: Experimental and theoretical research on magnetic confinement concepts, engineering and physics of existing and planned devices, including remote handling, development and testing of diagnostic tools and techniques in support of experiments, assembly and distribution to the fusion community of databases on atomic physics and radiation effects, development and testing of technologies for heating and fueling fusion plasmas, development and testing of superconducting magnets for containing fusion plasmas, development and testing of materials for fusion devices, and exploration of opportunities to apply the unique skills, technology, and techniques developed in the course of this work to other areas. Highlights from program activities are included in this report

Fusion Energy Division: Annual progress report, period ending December 31, 1987

International Nuclear Information System (INIS)

Morgan, O.B. Jr.; Berry, L.A.; Sheffield, J.

1988-11-01

The Fusion Program of Oak Ridge National Laboratory (ORNL), a major part of the national fusion program, carries out research in nearly all areas of magnetic fusion. Collaboration among staff from ORNL, Martin Marietta Energy Systems, Inc., private industry, the academic community, and other fusion laboratories, in the United States and abroad, is directed toward the development of fusion as an energy source. This report documents the program's achievements during 1987. Issued as the annual progress report of the ORNL Fusion Energy Division, it also contains information from components of the Fusion Program that are external to the division (about 15% of the program effort). The areas addressed by the Fusion Program include the following: experimental and theoretical research on magnetic confinement concepts, engineering and physics of existing and planned devices, development and testing of diagnostic tools and techniques in support of experiments, assembly and distribution to the fusion community of databases on atomic physics and radiation effects, development and testing of technologies for heating and fueling fusion plasmas, development and testing of superconducting magnets for containing fusion plasmas, and development and testing of materials for fusion devices. Highlights from program activities are included in this report. 126 figs., 15 tabs

Crevicular fluid biomarkers and periodontal disease progression.

Science.gov (United States)

Kinney, Janet S; Morelli, Thiago; Oh, Min; Braun, Thomas M; Ramseier, Christoph A; Sugai, Jim V; Giannobile, William V

2014-02-01

Assess the ability of a panel of gingival crevicular fluid (GCF) biomarkers as predictors of periodontal disease progression (PDP). In this study, 100 individuals participated in a 12-month longitudinal investigation and were categorized into four groups according to their periodontal status. GCF, clinical parameters and saliva were collected bi-monthly. Subgingival plaque and serum were collected bi-annually. For 6 months, no periodontal treatment was provided. At 6 months, patients received periodontal therapy and continued participation from 6 to 12 months. GCF samples were analysed by ELISA for MMP-8, MMP-9, Osteoprotegerin, C-reactive Protein and IL-1β. Differences in median levels of GCF biomarkers were compared between stable and progressing participants using Wilcoxon Rank Sum test (p = 0.05). Clustering algorithm was used to evaluate the ability of oral biomarkers to classify patients as either stable or progressing. Eighty-three individuals completed the 6-month monitoring phase. With the exception of GCF C-reactive protein, all biomarkers were significantly higher in the PDP group compared to stable patients. Clustering analysis showed highest sensitivity levels when biofilm pathogens and GCF biomarkers were combined with clinical measures, 74% (95% CI = 61, 86). Signature of GCF fluid-derived biomarkers combined with pathogens and clinical measures provides a sensitive measure for discrimination of PDP (ClinicalTrials.gov NCT00277745). © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Urinary liver-type fatty acid-binding protein predicts progression to nephropathy in type 1 diabetic patients

DEFF Research Database (Denmark)

Nielsen, Stine Elkjaer; Sugaya, Takeshi; Hovind, Peter

2010-01-01

Urinary liver-type fatty acid-binding protein (u-LFABP) is a marker of tubulointerstitial inflammation and has been shown to be increased in patients with type 1 diabetes and is further increased in patients who progress to micro- and macroalbuminuria. Our aim was to evaluate u-LFABP as a predictor...... of progression to micro- and macroalbuminuria in type 1 diabetes....

Task A: Research in theoretical elementary particle physics at the University of Florida; Annual progress report

Energy Technology Data Exchange (ETDEWEB)

Field, R.D.; Ramond, P.M.; Sikivie, P.; Thorn, C.B.

1993-11-01

This is the Annual Progress Report of the theoretical particle theory group at the University of Florida under DoE Grant DE-FG05-86ER40272. At present our group consists of four Full Professors (Field, Ramond, Thorn, Sikivie) and three Assistant Professors (Qiu, Woodard, Kennedy). Dallas Kennedy recently joined our group increasing the Particle Theory faculty to seven. In addition, we have three postdoctoral research associates, an SSC fellow, and eight graduate students. The research of our group covers a broad range of topics in theoretical high energy physics with balance between theory and phenomenology. Included in this report is a summary of the last several years of operation of the group and an outline of our current research program.

The Community's research and development programme on radioactive waste management and storage. Shared cost action. Annual progress report 1988. Volume 2

International Nuclear Information System (INIS)

Anon.

1989-01-01

Third annual progress report of the European Community's 1985-89 programme of research and development on radioactive waste management and disposal, carried out by public organizations and private firms in the Community under cost-sharing contracts with the Commission of the European Communities. This report describes the work to be carried out under research contracts already concluded before the end of 1988, as well as the work performed and the results obtained so far

The Community's research and development programme on radioactive waste management and storage. Shared cost action. Annual progress report 1988. Volume 1

International Nuclear Information System (INIS)

Anon.

1989-01-01

Third annual progress report of the European Community's 1985-89 programme of research and development on radioactive waste management and disposal, carried out by public organizations and private firms in the Community under cost-sharing contracts with the Commission of the European Communities. This report describes the work to be carried out under research contracts already concluded before the end of 1988, as well as the work performed and the results obtained so far

Energy Division annual progress report for period ending September 30, 1988: Volume 2

Energy Technology Data Exchange (ETDEWEB)

1989-06-01

The goals and accomplishments of the Energy Division of Oak Ridge National Laboratory are described in this annual progress report for Fiscal Year (FY) 1988. The Energy Division is a multidisciplinary research organization committed to (1) increasing the knowledge and understanding of the way society makes choices in energy use and energy-using technologies, (2) improving society's understanding of the environmental implications of changes in energy technology, and (3) improving and developing new energy-efficient technologies. The Energy Division's programmatic activities focus on four major areas: (1) analysis and assessment, (2) transportation and decision systems research, (3) technology research and development for improving the efficiency of energy and end-use technologies, and (4) electric power systems. The Division's total expenditures in FY 1988 were $44.3 million. The work is supported by the US Department of Energy, US Department of Defense, many other federal agencies, and some private organizations. Disciplines of the 139 staff members include engineering, social sciences, physical and life sciences, and mathematics and statistics.

IKO Annual Report 1976

International Nuclear Information System (INIS)

1977-01-01

The IKO Annual Report of 1976 relates their progress in different projects and project fields. The fields covered include electron scattering, pion and muon physics, theory, radio- and nuclear chemistry, technical department, MEA, nuclear reactions and nuclear spectroscopy

Uncovering SUMOylation Dynamics during Cell-Cycle Progression Reveals FoxM1 as a Key Mitotic SUMO Target Protein

DEFF Research Database (Denmark)

Schimmel, Joost; Eifler, Karolin; Sigurdsson, Jón Otti

2014-01-01

Loss of small ubiquitin-like modification (SUMOylation) in mice causes genomic instability due to the missegregation of chromosomes. Currently, little is known about the identity of relevant SUMO target proteins that are involved in this process and about global SUMOylation dynamics during cell......-cycle progression. We performed a large-scale quantitative proteomics screen to address this and identified 593 proteins to be SUMO-2 modified, including the Forkhead box transcription factor M1 (FoxM1), a key regulator of cell-cycle progression and chromosome segregation. SUMOylation of FoxM1 peaks during G2 and M...... relieving FoxM1 autorepression. Cells deficient for FoxM1 SUMOylation showed increased levels of polyploidy. Our findings contribute to understanding the role of SUMOylation during cell-cycle progression....

Progress report on nuclear science and technology in China (Vol.1). Proceedings of academic annual meeting of China Nuclear Society in 2009, No.8--isotope

International Nuclear Information System (INIS)

2010-11-01

Progress report on nuclear science and technology in China (Vol. 1) includes 889 articles which are communicated on the first national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the eighth one, the content is about radiation study, radiation technology, isotope and nuclear agriculture

Recent Progress and Development of Crystal Structure Analysis of Enzymes and Other Proteins

Science.gov (United States)

Tanokura, Masaru; Nagata, Koji; Miyazono, Ken-Ichi; Miyakawa, Takuya; Okai, Masahiko

Structural biology has made tremendous progress in this decade. Here we briefly introduce the Target Proteins Research Program, a national project promoted by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan. The program aims to reveal the structure and function of proteins that are of great importance in both academic research and industrial application. We also summarize the results of structure-function analyses of (i) transcriptional regulatory proteins useful for the breading of drought and heat stress tolerant crops, (ii) useful enzymes for the production of chiral compounds, and (iii) useful enzymes for the degradation of environmental pollution substances. These results can be utilized in various areas of industries, to enhance food production, to improve the efficiency of pharmaceutical compound production, and to promote the bioremediation of contaminated soil and water.

Fiscal Year 1994 progress in implementing Section 120 of the Comprehensive Environmental Rresponse, Compensation, and Liability Act. Eighth annual report to Congress

International Nuclear Information System (INIS)

1995-07-01

Congress passed the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) (Public Law 96-510), commonly known as Superfund, in 1980. The Superfund Amendments and Reauthorization Act (SARA) (Public Law 99-499), which amended CERCLA in 1986, added Section 120 regarding the cleanup of contaminated sites at Federal facilities. Under Section 120(e)(5) of CERCLA, each department, agency, or instrumentality of the Federal government responsible for compliance with Section 120 must submit an annual report to Congress concerning its progress in implementing the requirements of Section 120. The report must include information on the progress in reaching Interagency Agreements (IAGs), conducting Remedial Investigation and Feasibility Studies (RI/FSs), and performing remedial actions. Federal agencies that own or operate facilities on the National Priorities List (NPL) are required to begin an RI/FS for these facilities within 6 months after being placed on the NPL. Remediation of these facilities is addressed in an IAG between the Federal agency, the U.S. Environmental Protection Agency (EPA), and in some instances the state within which the facility is located. This report, prepared by the U.S. Department of Energy's (DOE's) Office of Environmental Management, is being submitted to Congress in accordance with Section 120(e)(5) of CERCLA. It is DOE's Eighth Annual Report to Congress and provides information on DOE's progress in implementing CERCLA Section 120 in Fiscal Year 1994 (FY 94), i.e., from October 1, 1993, to September 30, 1994. In this report the words open-quotes siteclose quotes and open-quotes facilityclose quotes are used interchangeably

Muscle-Derived Proteins as Serum Biomarkers for Monitoring Disease Progression in Three Forms of Muscular Dystrophy

Science.gov (United States)

Burch, Peter M.; Pogoryelova, Oksana; Goldstein, Richard; Bennett, Donald; Guglieri, Michela; Straub, Volker; Bushby, Kate; Lochmüller, Hanns; Morris, Carl

2015-01-01

Abstract Background: Identifying translatable, non-invasive biomarkers of muscular dystrophy that better reflect the disease pathology than those currently available would aid the development of new therapies, the monitoring of disease progression and the response to therapy. Objective: The goal of this study was to evaluate a panel of serum protein biomarkers with the potential to specifically detect skeletal muscle injury. Method: Serum concentrations of skeletal troponin I (sTnI), myosin light chain 3 (Myl3), fatty acid binding protein 3 (FABP3) and muscle-type creatine kinase (CKM) proteins were measured in 74 Duchenne muscular dystrophy (DMD), 38 Becker muscular dystrophy (BMD) and 49 Limb-girdle muscular dystrophy type 2B (LGMD2B) patients and 32 healthy controls. Results: All four proteins were significantly elevated in the serum of these three muscular dystrophy patient populations when compared to healthy controls, but, interestingly, displayed different profiles depending on the type of muscular dystrophy. Additionally, the effects of patient age, ambulatory status, cardiac function and treatment status on the serum concentrations of the proteins were investigated. Statistical analysis revealed correlations between the serum concentrations and certain clinical endpoints including forced vital capacity in DMD patients and the time to walk ten meters in LGMD2B patients. Serum concentrations of these proteins were also elevated in two preclinical models of muscular dystrophy, the mdx mouse and the golden-retriever muscular dystrophy dog. Conclusions: These proteins, therefore, are potential muscular dystrophy biomarkers for monitoring disease progression and therapeutic response in both preclinical and clinical studies. PMID:26870665

Progress report on nuclear science and technology in China (Vol.1). Proceedings of academic annual meeting of China Nuclear Society in 2009, No.6--nuclear physics

International Nuclear Information System (INIS)

2010-11-01

Progress report on nuclear science and technology in China (Vol. 1) includes 889 articles which are communicated on the first national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the sixth one, the content is about nuclear physics, computational physics and particle accelerator

Identification of a novel centrosomal protein CrpF46 involved in cell cycle progression and mitosis

International Nuclear Information System (INIS)

Wei Yi; Shen Enzhi; Zhao Na; Liu Qian; Fan Jinling; Marc, Jan; Wang Yongchao; Sun Le; Liang Qianjin

2008-01-01

A novel centrosome-related protein Crp F46 was detected using a serum F46 from a patient suffering from progressive systemic sclerosis. We identified the protein by immunoprecipitation and Western blotting followed by tandem mass spectrometry sequencing. The protein Crp F46 has an apparent molecular mass of ∼ 60 kDa, is highly homologous to a 527 amino acid sequence of the C-terminal portion of the protein Golgin-245, and appears to be a splice variant of Golgin-245. Immunofluorescence microscopy of synchronized HeLa cells labeled with an anti-Crp F46 monoclonal antibody revealed that Crp F46 localized exclusively to the centrosome during interphase, although it dispersed throughout the cytoplasm at the onset of mitosis. Domain analysis using Crp F46 fragments in GFP-expression vectors transformed into HeLa cells revealed that centrosomal targeting is conferred by a C-terminal coiled-coil domain. Antisense Crp F46 knockdown inhibited cell growth and proliferation and the cell cycle typically stalled at S phase. The knockdown also resulted in the formation of poly-centrosomal and multinucleate cells, which finally became apoptotic. These results suggest that Crp F46 is a novel centrosome-related protein that associates with the centrosome in a cell cycle-dependent manner and is involved in the progression of the cell cycle and M phase mechanism

Sustainability Annual Report 2013

OpenAIRE

2013-01-01

Every year, Virginia Tech releases a sustainability annual report to show the university’s progress in meeting the sustainability goals. The key sustainability metrics these reports cover include: greenhouse gas (GHG) emissions, energy use intensity, alternative transportation use, recycling, and water consumption.

Sustainability Annual Report 2014

OpenAIRE

2014-01-01

Every year, Virginia Tech releases a sustainability annual report to show the university’s progress in meeting the sustainability goals. The key sustainability metrics these reports cover include: greenhouse gas (GHG) emissions, energy use intensity, alternative transportation use, recycling, and water consumption.

Sustainability Annual Report 2017

OpenAIRE

2017-01-01

Every year, Virginia Tech releases a sustainability annual report to show the university’s progress in meeting the sustainability goals. The key sustainability metrics these reports cover include: greenhouse gas (GHG) emissions, energy use intensity, alternative transportation use, recycling, and water consumption.

Sustainability Annual Report 2011

OpenAIRE

2011-01-01

Every year, Virginia Tech releases a sustainability annual report to show the university’s progress in meeting the sustainability goals. The key sustainability metrics these reports cover include: greenhouse gas (GHG) emissions, energy use intensity, alternative transportation use, recycling, and water consumption.

Sustainability Annual Report 2012

OpenAIRE

2012-01-01

Every year, Virginia Tech releases a sustainability annual report to show the university’s progress in meeting the sustainability goals. The key sustainability metrics these reports cover include: greenhouse gas (GHG) emissions, energy use intensity, alternative transportation use, recycling, and water consumption.

Sustainability Annual Report 2015

OpenAIRE

2015-01-01

Every year, Virginia Tech releases a sustainability annual report to show the university’s progress in meeting the sustainability goals. The key sustainability metrics these reports cover include: greenhouse gas (GHG) emissions, energy use intensity, alternative transportation use, recycling, and water consumption.

Sustainability Annual Report 2016

OpenAIRE

2016-01-01

Every year, Virginia Tech releases a sustainability annual report to show the university’s progress in meeting the sustainability goals. The key sustainability metrics these reports cover include: greenhouse gas (GHG) emissions, energy use intensity, alternative transportation use, recycling, and water consumption.

High temperature turbine technology program. Phase II. Technology test and support studies. Annual technical progress report, January 1, 1979-December 31, 1979

Energy Technology Data Exchange (ETDEWEB)

1980-01-01

Work performed on the High Temperature Turbine Technology Program, Phase II - Technology Test and Support Studies during the period from January 1, 1979 through December 31, 1979 is summarized. Objectives of the program elements as well as technical progress and problems encountered during this Phase II annual reporting period are presented. Progress on design, fabrication and checkout of test facilities and test rigs is described. LP turbine cascade tests were concluded. 350 hours of testing were conducted on the LP rig engine first with clean distillate fuel and then with fly ash particulates injected into the hot gas stream. Design and fabrication of the turbine spool technology rig components are described. TSTR 60/sup 0/ sector combustor rig fabrication and testing are reviewed. Progress in the design and fabrication of TSTR cascade rig components for operation on both distillate fuel and low Btu gas is described. The new coal-derived gaseous fuel synthesizing facility is reviewed. Results and future plans for the supporting metallurgical programs are discussed.

Progress report on nuclear science and technology in China (Vol.1). Proceedings of academic annual meeting of China Nuclear Society in 2009, No.4--nuclear material

International Nuclear Information System (INIS)

2010-11-01

Progress report on nuclear science and technology in China (Vol. 1) includes 889 articles which are communicated on the first national academic annual meeting of China Nuclear Society. There are 10 books totally.This is the fourth one, the content is about nuclear materials, isotope separation, nuclear chemistry and radiological chemistry.

Progress report on nuclear science and technology in China (Vol.1). Proceedings of academic annual meeting of China Nuclear Society in 2009, No.8--nuclear agriculture

International Nuclear Information System (INIS)

2010-11-01

Progress report on nuclear science and technology in China (Vol. 1) includes 889 articles which are communicated on the first national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the eighth one, the content is about radiation study, radiation technology, isotope and nuclear agriculture

Annual report on reactor safety research projects sponsored by the Ministry of Economics and Technology of the Federal Republic of Germany. Reporting period 2005. Progress report

International Nuclear Information System (INIS)

2005-01-01

Within its competence for energy research, the Bundesministerium fuer Wirtschaft und Technology (BMWi) (Federal Ministry of Economics and Technology) sponsors investigations into the safety of nuclear power plants. The objective of these investigations is to provide fundamental knowledge, procedures and methods to contribute to realistic safety assessments of nuclear installations, to the further development of safety technology and to make use of the potential of innovative safety-related approaches. The Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH, by order of the BMWi, continuously issues information on the status of such investigations by publishing semi-annual and annual progress reports within the series of GRS-F-Fortschrittsberichte (GRS-F-Progress Reports). Each progress report represents a compilation of individual reports about the objectives, work performed, results achieved, next steps of the work etc. The individual reports are prepared in a standard form by the research organisations themselves as documentation of their progress in work and are published by the Research Management Division of GRS within the framework of general information on the progress in reactor safety research. The compilation of the reports is classified according to general topics related to reactor safety research. Further, use is made of the classification system 'Joint Safety Research Index' of the CEC (Commission of the European Communities). The reports are arranged in sequence of their project numbers. It has to be pointed out that the authors of the reports are responsible for the contents of this compilation. The BMWi does not take any responsibility for the correctness, exactness and completeness of the information nor for the observance of private claims of third parties. (orig.)

Annual report on reactor safety research projects sponsored by the Ministry of Economics and Technology of the Federal Republic of Germany. Reporting period 2007. Progress report

International Nuclear Information System (INIS)

2007-01-01

Within its competence for energy research the Federal Ministry of Economics and Technology (BMWi) sponsors research projects on the safety of nuclear power plants currently in operation. The objective of these projects is to provide fundamental knowledge, procedures and methods to contribute to realistic safety assessments of nuclear installations, to the further development of safety technology and to make use of the potential of innovative safety-related approaches. The Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH, by order of the BMWi, continuously issues information on the status of such research projects by publishing semi-annual and annual progress reports within the series of GRS-F-Fortschrittsberichte (GRS-F-Progress Reports). Each progress report represents a compilation of individual reports about the objectives, work performed, results achieved, next steps of the work etc. The individual reports are prepared in a standard form by the research organisations themselves as documentation of their progress in work. The progress reports are published by the Research Management Division of GRS. The reports as of the year 2000 are available in the Internet-based information system on results and data of reactor safety research (http://www.grs-fbw.de). The compilation of the reports is classified according to the classification system 'Joint Safety Research Index (JSRI)'. The reports are arranged in sequence of their project numbers. It has to be pointed out that the authors of the reports are responsible for the contents of this compilation. The BMWi does not take any responsibility for the correctness, exactness and completeness of the information nor for the observance of private claims of third parties. (orig.)

Annual report on reactor safety research projects sponsored by the Ministry of Economics and Labour of the Federal Republic of Germany. Reporting period 2004. Progress report

International Nuclear Information System (INIS)

2004-01-01

Within its competence for energy research, the Bundesministerium fuer Wirtschaft und Technology (BMWi) (Federal Ministry of Economics and Technology) sponsors investigations into the safety of nuclear power plants. The objective of these investigations is to provide fundamental knowledge, procedures and methods to contribute to realistic safety assessments of nuclear installations, to the further development of safety technology and to make use of the potential of innovative safety-related approaches. The Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH, by order of the BMWi, continuously issues information on the status of such investigations by publishing semi-annual and annual progress reports within the series of GRS-F-Fortschrittsberichte (GRS-F-Progress Reports). Each progress report represents a compilation of individual reports about the objectives, work performed, results achieved, next steps of the work etc. The individual reports are prepared in a standard form by the research organisations themselves as documentation of their progress in work and are published by the Research Management Division of GRS within the framework of general information on the progress in reactor safety research. The compilation of the reports is classified according to general topics related to reactor safety research. Further, use is made of the classification system 'Joint Safety Research Index' of the CEC (Commission of the European Communities). The reports are arranged in sequence of their project numbers. It has to be pointed out that the authors of the reports are responsible for the contents of this compilation. The BMWi does not take any responsibility for the correctness, exactness and completeness of the information nor for the observance of private claims of third parties. (orig.)

Annual report on reactor safety research projects sponsored by the Ministry of Economics and Labour of the Federal Republic of Germany. Reporting period 2004. Progress report

Energy Technology Data Exchange (ETDEWEB)

NONE

2004-07-01

Within its competence for energy research, the Bundesministerium fuer Wirtschaft und Technology (BMWi) (Federal Ministry of Economics and Technology) sponsors investigations into the safety of nuclear power plants. The objective of these investigations is to provide fundamental knowledge, procedures and methods to contribute to realistic safety assessments of nuclear installations, to the further development of safety technology and to make use of the potential of innovative safety-related approaches. The Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH, by order of the BMWi, continuously issues information on the status of such investigations by publishing semi-annual and annual progress reports within the series of GRS-F-Fortschrittsberichte (GRS-F-Progress Reports). Each progress report represents a compilation of individual reports about the objectives, work performed, results achieved, next steps of the work etc. The individual reports are prepared in a standard form by the research organisations themselves as documentation of their progress in work and are published by the Research Management Division of GRS within the framework of general information on the progress in reactor safety research. The compilation of the reports is classified according to general topics related to reactor safety research. Further, use is made of the classification system 'Joint Safety Research Index' of the CEC (Commission of the European Communities). The reports are arranged in sequence of their project numbers. It has to be pointed out that the authors of the reports are responsible for the contents of this compilation. The BMWi does not take any responsibility for the correctness, exactness and completeness of the information nor for the observance of private claims of third parties. (orig.)

Energy Division annual progress report for period ending September 30, 1990

Energy Technology Data Exchange (ETDEWEB)

Selden, R.H. (ed.)

1991-06-01

The Energy Division is one of 17 research divisions at Oak Ridge National Laboratory. The goals and accomplishments of the Energy Division are described in this annual progress report for FY 1990. The Energy Division is a multidisciplinary research organization committed to (1) increasing the knowledge and understanding of how societies make choices in energy use; (2) improving society's understanding of the environmental, social, and economic implications of technological change; (3) developing and transferring energy efficient technologies; and (4) developing improved transportation planning and policy. Disciplines of the 129 staff members include engineering, social sciences, physical and life sciences, and mathematics and statistics. The Energy Division's programmatic activities focus on three major areas: (1) analysis and assessment, (2) energy conservation technologies, and (3) military transportation systems. Analysis and assessment activities cover energy and resource analysis, the preparation of environmental assessments and impact statements, research on waste management, analysis of emergency preparedness for natural and technological disasters, analysis of the energy and environmental needs of developing countries, technology transfer, and analysis of civilian transportation. Energy conservation technologies include building equipment (thermally activated heat pumps, chemical heat pumps, refrigeration systems, novel cycles), building enveloped (walls, foundations, roofs, attics, and materials), retrofits for existing buildings, and electric power systems. Military transportation systems concentrate on research for sponsors within the US military on improving the efficiency of military deployment, scheduling, and transportation coordination. 48 refs., 34 figs., 7 tabs.

The Multifunctional Protein Kinase C-ε in Cancer Development and Progression

Science.gov (United States)

Jain, Kirti; Basu, Alakananda

2014-01-01

The protein kinase C (PKC) family proteins are important signal transducers and have long been the focus of cancer research. PKCɛ, a member of this family, is overexpressed in most solid tumors and plays critical roles in different processes that lead to cancer development. Studies using cell lines and animal models demonstrated the transforming potential of PKCɛ. While earlier research established the survival functions of PKCɛ, recent studies revealed its role in cell migration, invasion and cancer metastasis. PKCɛ has also been implicated in epithelial to mesenchymal transition (EMT), which may be the underlying mechanism by which it contributes to cell motility. In addition, PKCɛ affects cell-extracellular matrix (ECM) interactions by direct regulation of the cytoskeletal elements. Recent studies have also linked PKCɛ signaling to cancer stem cell functioning. This review focuses on the role of PKCɛ in different processes that lead to cancer development and progression. We also discussed current literatures on the pursuit of PKCɛ as a target for cancer therapy. PMID:24727247

The Multifunctional Protein Kinase C-ε in Cancer Development and Progression

Directory of Open Access Journals (Sweden)

Kirti Jain

2014-04-01

Full Text Available The protein kinase C (PKC family proteins are important signal transducers and have long been the focus of cancer research. PKCɛ, a member of this family, is overexpressed in most solid tumors and plays critical roles in different processes that lead to cancer development. Studies using cell lines and animal models demonstrated the transforming potential of PKCɛ. While earlier research established the survival functions of PKCɛ, recent studies revealed its role in cell migration, invasion and cancer metastasis. PKCɛ has also been implicated in epithelial to mesenchymal transition (EMT, which may be the underlying mechanism by which it contributes to cell motility. In addition, PKCɛ affects cell-extracellular matrix (ECM interactions by direct regulation of the cytoskeletal elements. Recent studies have also linked PKCɛ signaling to cancer stem cell functioning. This review focuses on the role of PKCɛ in different processes that lead to cancer development and progression. We also discussed current literatures on the pursuit of PKCɛ as a target for cancer therapy.

The Multifunctional Protein Kinase C-ε in Cancer Development and Progression

International Nuclear Information System (INIS)

Jain, Kirti; Basu, Alakananda

2014-01-01

The protein kinase C (PKC) family proteins are important signal transducers and have long been the focus of cancer research. PKCε, a member of this family, is overexpressed in most solid tumors and plays critical roles in different processes that lead to cancer development. Studies using cell lines and animal models demonstrated the transforming potential of PKCε. While earlier research established the survival functions of PKCε, recent studies revealed its role in cell migration, invasion and cancer metastasis. PKCε has also been implicated in epithelial to mesenchymal transition (EMT), which may be the underlying mechanism by which it contributes to cell motility. In addition, PKCε affects cell-extracellular matrix (ECM) interactions by direct regulation of the cytoskeletal elements. Recent studies have also linked PKCε signaling to cancer stem cell functioning. This review focuses on the role of PKCε in different processes that lead to cancer development and progression. We also discussed current literatures on the pursuit of PKCε as a target for cancer therapy.

The Multifunctional Protein Kinase C-ε in Cancer Development and Progression

Energy Technology Data Exchange (ETDEWEB)

Jain, Kirti; Basu, Alakananda, E-mail: alakananda.basu@unthsc.edu [Department of Molecular and Medical Genetics, University of North Texas Health Science Center, Institute for Cancer Research, and Focused on Resources for her Health Education and Research, Fort Worth, TX 76107 (United States)

2014-04-10

The protein kinase C (PKC) family proteins are important signal transducers and have long been the focus of cancer research. PKCε, a member of this family, is overexpressed in most solid tumors and plays critical roles in different processes that lead to cancer development. Studies using cell lines and animal models demonstrated the transforming potential of PKCε. While earlier research established the survival functions of PKCε, recent studies revealed its role in cell migration, invasion and cancer metastasis. PKCε has also been implicated in epithelial to mesenchymal transition (EMT), which may be the underlying mechanism by which it contributes to cell motility. In addition, PKCε affects cell-extracellular matrix (ECM) interactions by direct regulation of the cytoskeletal elements. Recent studies have also linked PKCε signaling to cancer stem cell functioning. This review focuses on the role of PKCε in different processes that lead to cancer development and progression. We also discussed current literatures on the pursuit of PKCε as a target for cancer therapy.

Progress report on nuclear science and technology in China (Vol.1). Proceedings of academic annual meeting of China Nuclear Society in 2009, No.7--nuclear fusion

International Nuclear Information System (INIS)

2010-11-01

Progress report on nuclear science and technology in China (Vol. 1) includes 889 articles which are communicated on the first national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the seventh one, the content is about nuclear electronics, nuclear detecting technology, pulse power technology, nuclear fusion and plasma

Assessment of Food Chain Pathway Parameters in Biosphere Models: Annual Progress Report for Fiscal Year 2004

Energy Technology Data Exchange (ETDEWEB)

Napier, Bruce A.; Krupka, Kenneth M.; Fellows, Robert J.; Cataldo, Dominic A.; Valenta, Michelle M.; Gilmore, Tyler J.

2004-12-02

This Annual Progress Report describes the work performed and summarizes some of the key observations to date on the U.S. Nuclear Regulatory Commission’s project Assessment of Food Chain Pathway Parameters in Biosphere Models, which was established to assess and evaluate a number of key parameters used in the food-chain models used in performance assessments of radioactive waste disposal facilities. Section 2 of this report describes activities undertaken to collect samples of soils from three regions of the United States, the Southeast, Northwest, and Southwest, and perform analyses to characterize their physical and chemical properties. Section 3 summarizes information gathered regarding agricultural practices and common and unusual crops grown in each of these three areas. Section 4 describes progress in studying radionuclide uptake in several representative crops from the three soil types in controlled laboratory conditions. Section 5 describes a range of international coordination activities undertaken by Project staff in order to support the underlying data needs of the Project. Section 6 provides a very brief summary of the status of the GENII Version 2 computer program, which is a “client” of the types of data being generated by the Project, and for which the Project will be providing training to the US NRC staff in the coming Fiscal Year. Several appendices provide additional supporting information.

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.10--Nuclear Information sub-volume

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 28 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the tenth one, the content is about Nuclear Information sub-volume

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.8--nuclear agriculture sub-volume

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 10 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the eighth one, the content is about nuclear agriculture sub-volume

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.4--isotope separation sub-volume

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 37 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the fourth one, the content is about isotope separation sub-volume

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.6--computational physics sub-volume

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 13 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the sixth one, the content is about computational physics sub-volume

Progress report on nuclear science and technology in China (Vol.2). Proceedings of academic annual meeting of China Nuclear Society in 2011, No.10--nuclear Information sub-volume

International Nuclear Information System (INIS)

2012-10-01

Progress report on nuclear science and technology in China (Vol. 2) includes 698 articles which are communicated on the second national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the tenth one, the content is about nuclear Information and computer applications

FY2016 Lightweight Materials Annual Progress Report

Energy Technology Data Exchange (ETDEWEB)

None, None

2017-10-31

The Lightweight Materials research and development (R&D) area within the DOE Vehicle Technologies Office (VTO) provides support and guidance for many cutting-edge automotive technologies under development. Research focuses on addressing critical barriers to commercializing lightweight materials for passenger and commercial vehicles. This report describes the progress made on the research and development projects funded by the Lightweight Materials area.

BAM - Annual report 1975

International Nuclear Information System (INIS)

1976-06-01

The annual report contains progress and activity reports of the presidential department, the departments metals and metal construction, civil engineering and building activities, organic matter, chemical safety engineering, special fields of materials testing, techniques independent of the type of material, an index, as well as general and statistic statements. (HK) [de

Protein Analysis in Human Cerebrospinal Fluid: Physiological Aspects, Current Progress and Future Challenges

Directory of Open Access Journals (Sweden)

Andreas F. Hühmer

2006-01-01

Full Text Available The introduction of lumbar puncture into clinical medicine over 100 years ago marks the beginning of the study of central nervous system diseases using the human cerebrospinal fluid (CSF. Ever since, CSF has been analyzed extensively to elucidate the physiological and biochemical bases of neurological disease. The proximity of CSF to the brain makes it a good target for studying the pathophysiology of brain functions, but the barrier function of the CSF also impedes its diagnostic value. Today, measurements to determine alterations in the composition of CSF are central in the differential diagnosis of specific diseases of the central nervous system (CNS. In particular, the analysis of the CSF protein composition provides crucial information in the diagnosis of CNS diseases. This enables the assessment of the physiology of the blood-CSF barrier and of the immunology of intrathecial responses. Besides those routine measurements, protein compositional studies of CSF have been extended recently to many other proteins in the expectation that comprehensive analysis of lower abundance CSF proteins will lead to the discovery of new disease markers. Disease marker discovery by molecular profiling of the CSF tissue has the enormous potential of providing many new disease relevant molecules. New developments in protein profiling techniques hold promise for the discovery and validation of relevant disease markers. In this review, we summarize the current efforts and progress in CSF protein profiling measurements using conventional and current protein analysis tools. We also discuss necessary development in methodology in order to have the highest impact on the study of the molecular composition of CSF proteins.

Energy Division annual progress report for period ending September 30, 1992

Energy Technology Data Exchange (ETDEWEB)

Counce, D.M.; Wolff, P.P. [eds.

1993-04-01

Energy Division`s mission is to provide innovative solutions to energy and related Issues of national and global importance through interdisciplinary research and development. Its goals and accomplishments are described in this annual progress report for FY 1992. Energy Division`s total expenditures in FY 1992 were $42.8 million. The work is supported by the US Department of Energy, the US Department of Defense, many other federal agencies, and some private organizations. Disciplines of the 116.5 technical staff members include engineering, social sciences, physical and life sciences, and mathematics and statistics. The division`s programmatic activities cover three main areas: (1) analysis and assessment, (2) energy conservation technologies, and (3) military transportation systems. Analysis and assessment activities involve energy and resource analysis, preparation of environmental assessments and impact statements, research on waste management, technology transfer, analysis of energy and environmental needs in developing countries, and civilian transportation analysis. Energy conservation technologies focus on electric power systems, building envelopes (walls, foundations, roofs, attics, and materials), and methods to improve energy efficiency in existing buildings. Military transportation systems conduct research for sponsors within the US military to improve the efficiency of military deployment, scheduling, and transportation coordination. Much of Energy Division`s research is valuable to other organizations as well as to sponsors. This information is disseminated by the staff`s involvement in professional and trade organizations and workshops; joint research with universities and private-sector firms; collaboration with state and local governments; presentation of work at conferences; and publication of research results in journals, reports, and conference proceedings.

A Critical Role of TET1/2 Proteins in Cell-Cycle Progression of Trophoblast Stem Cells

Directory of Open Access Journals (Sweden)

Stephanie Chrysanthou

2018-04-01

Full Text Available Summary: The ten-eleven translocation (TET proteins are well known for their role in maintaining naive pluripotency of embryonic stem cells. Here, we demonstrate that, jointly, TET1 and TET2 also safeguard the self-renewal potential of trophoblast stem cells (TSCs and have partially redundant roles in maintaining the epithelial integrity of TSCs. For the more abundantly expressed TET1, we show that this is achieved by binding to critical epithelial genes, notably E-cadherin, which becomes hyper-methylated and downregulated in the absence of TET1. The epithelial-to-mesenchymal transition phenotype of mutant TSCs is accompanied by centrosome duplication and separation defects. Moreover, we identify a role of TET1 in maintaining cyclin B1 stability, thereby acting as facilitator of mitotic cell-cycle progression. As a result, Tet1/2 mutant TSCs are prone to undergo endoreduplicative cell cycles leading to the formation of polyploid trophoblast giant cells. Taken together, our data reveal essential functions of TET proteins in the trophoblast lineage. : TET proteins are well known for their role in pluripotency. Here, Hemberger and colleagues show that TET1 and TET2 are also critical for maintaining the epithelial integrity of trophoblast stem cells. TET1/2 ensure mitotic cell-cycle progression by stabilizing cyclin B1 and by regulating centrosome organization. These insights reveal the importance of TET proteins beyond their role in epigenome remodeling. Keywords: TET proteins, trophoblast stem cells, cell cycle, endoreduplication, self-renewal, mitosis, trophoblast giant cells, differentiation

FY13 Annual Progress Report for SECA Core Technology Program

Energy Technology Data Exchange (ETDEWEB)

Stevenson, Jeffry W. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Koeppel, Brian J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

2014-01-31

This progress report covers technical work performed during fiscal year 2013 at PNNL under Field Work Proposal (FWP) 40552. The report highlights and documents technical progress in tasks related to advanced cell and stack component materials development and computational design and simulation.

Progress report on nuclear science and technology in China (Vol.1). Proceedings of academic annual meeting of China Nuclear Society in 2009, No.7--pulse power technology

International Nuclear Information System (INIS)

2010-11-01

Progress report on nuclear science and technology in China (Vol. 1) includes 889 articles which are communicated on the first national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the seventh one, the content is about nuclear electronics, nuclear detecting technology, pulse power technology, nuclear fusion and plasma

Annual genome conference. Final report, September 1, 1994--August 31, 1995

Energy Technology Data Exchange (ETDEWEB)

Gardiner, K.

1995-11-01

Tremendous progress has been made in the construction of physical and genetic maps of the human chromosomes. The next step in the solving of disease related problems, and in understanding the human genome as a whole, is the systematic isolation of transcribed sequences. Many investigators have already embarked upon comprehensive gene searches, and many more are considering the best strategies for undertaking such searches. Because these are likely to be costly and time consuming endeavors, it is important to determine the most efficient approaches. As a result, it is critical that investigators involved in the construction of transcriptional maps have the opportunity to discuss their experiences and their successes with both old and new technologies. This document contains the proceedings of the Fourth Annual Workshop on the Identification of Transcribed Sequences, held in Montreal, Quebec, October 16-18, 1994. Included are the workshop notebook, containing the agenda, abstracts presented and list of attendees. Topics included: Progress in the application of the hybridization based approaches and exon trapping; Progress in transcriptional map construction of selected genomic regions; Computer assisted analysis of genomic and protein coding sequences and additional new approaches; and, Sequencing and mapping of random cDNAs.

High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progression

International Nuclear Information System (INIS)

Egerod, Frederikke Lihme; Bartels, Annette; Fristrup, Niels; Borre, Michael; Ørntoft, Torben F; Oleksiewicz, Martin B; Brünner, Nils; Dyrskjøt, Lars

2009-01-01

Egr-1 (early growth response-1 transcription factor) has been proposed to be involved in invasion and metastasis processes of human bladder cancer, but Egr-1 protein expression levels in human bladder cancer have not been investigated. In the present study we investigated the expression levels of Egr-1 protein in early stages of human bladder cancer and correlated it to later progression. Expression of Egr-1 protein in human bladder cancer was examined by immunohistochemistry, on a tissue microarray constructed from tumors from 289 patients with non-muscle invasive urothelial bladder cancer. The frequency of tumor cells with nuclear Egr-1 immunolabelling correlated to bladder cancer stage, grade and to later progression to muscle-invasive bladder cancer (T2-4). Stage T1 tumors exhibited significantly higher frequencies of tumor cells with nuclear Egr-1 immunolabelling than Ta tumors (P = 0.001). Furthermore, Kaplan-Meier survival analysis showed that a high frequency of tumor cells with nuclear Egr-1 immunolabelling was significantly associated with a higher risk of progression to stage T2-4 (log-rank test, P = 0.035). Tumor cells with nuclear Egr-1 immunolabelling were found to localize at the tumor front in some of the tumor biopsies. The results from this study support a potential involvement of Egr-1 in the progression from non-muscle invasive bladder cancers to muscle invasive bladder cancer

Heat shock protein 27 phosphorylation state is associated with cancer progression

Directory of Open Access Journals (Sweden)

Maria eKatsogiannou

2014-10-01

Full Text Available Understanding the mechanisms that control stress-induced survival is critical to explain how tumors frequently resist to treatment and to improve current anti-cancer therapies. Cancer cells are able to cope with stress and escape drug toxicity by regulating heat shock proteins (Hsps expression and function. Hsp27 (HSPB1, a member of the small Hsp family, represents one of the key players of many signaling pathways contributing to tumorigenicity, treatment resistance and apoptosis inhibition. Hsp27 is overexpressed in many types of cancer and its functions are regulated by post-translational modifications, such as phosphorylation. Protein phosphorylation is the most widespread signaling mechanism in eukaryotic cells, and it is involved in all fundamental cellular processes. Aberrant phosphorylation of Hsp27 has been associated with several diseases such as cancer but the molecular mechanisms by which it is implicated in cancer development and progression remain undefined. This review focuses on the role of phosphorylation in Hsp27 functions in cancer cells and its potential usefulness as therapeutic target in cancer.

Annual Research Progress Report. Fiscal Year 1989. Volume 1

Science.gov (United States)

1989-10-01

Surgery, New Orleans, LA, 24-28 September 1989. Elledge, E.S. Tonsillar Squamous Cell Carcinoma Metastatic to a Branchial Cleft Cyst. American Academy of...Symposium, Washington, DC, 6 May 1989. Gibbons, D.R. Spontaneous Otorrhea from Tegmen and Labryinthine Congenital Anomalies . Annual Meeting of the...Head, H.D. Surgical Therapy in the Management of Coronary Anomalies . Ann. Thor. Surg., (in press). Neurosurgery Service Goldring, S., Gregorie, E

Annual report of waste generation and pollution prevention progress 1999

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-09-01

This Annual Report summarizes and highlights waste generation, waste reduction, pollution prevention accomplishments, and cost avoidance for 44 U.S. Department of Energy reporting sites for Calendar Year 1999. This section summarizes Calendar Year 1999 Complex-wide waste generation and pollution prevention accomplishments.

Annual report of waste generation and pollution prevention progress 1999

International Nuclear Information System (INIS)

2000-01-01

This Annual Report summarizes and highlights waste generation, waste reduction, pollution prevention accomplishments, and cost avoidance for 44 U.S. Department of Energy reporting sites for Calendar Year 1999. This section summarizes Calendar Year 1999 Complex-wide waste generation and pollution prevention accomplishments

Urinary liver-type fatty acid-binding protein predicts progression to nephropathy in type 1 diabetic patients

DEFF Research Database (Denmark)

Nielsen, Stine Elkjaer; Sugaya, Takeshi; Hovind, Peter

2010-01-01

Urinary liver-type fatty acid-binding protein (u-LFABP) is a marker of tubulointerstitial inflammation and has been shown to be increased in patients with type 1 diabetes and is further increased in patients who progress to micro- and macroalbuminuria. Our aim was to evaluate u-LFABP as a predictor...

Energy Division annual progress report for period ending September 30, 1993

Energy Technology Data Exchange (ETDEWEB)

Wolff, P.P. [ed.

1994-07-01

One of 17 research divisions at Oak Ridge National Laboratory, Energy Division`s mission is to provide innovative solutions to energy and related issues of national and global importance through interdisciplinary research and development. Its goals and accomplishments are described in this annual progress report for FY1993. Energy Division is committed to (1) understanding the mechanisms by which societies make choices in energy use; (2) improving society`s understanding of the environmental, social, and economic implications of technological change; (3) developing and transferring energy-efficient technologies; (4) improving transportation policy and planning; (5) enhancing basic knowledge in the social sciences as related to energy and associated issues. Energy Division`s expenditures in FY1993 totaled $42 million. The work was supported by the US DOE, DOD, many other federal agencies, and some private organizations. Disciplines of the 126.5 technical staff members include engineering, social sciences, physical and life sciences, and computer sciences and data systems. The division`s programmatic activities cover three main areas: (1) analysis and assessment, (2) energy use and delivery technologies, and (3) transportation systems. Analysis and assessment activities involve energy and resource analysis, preparation of environmental assessments and impact statements, research on emergency preparedness, transportation analysis, and analysis of energy and environmental needs in developing countries. Energy use and delivery technologies focus on electric power systems, building equipment, building envelopes (walls, foundations, roofs, attics, and materials), and methods to improve energy efficiency in existing buildings. Transportation systems research is conducted both to improve the quality of civilian transportation and for sponsors within the US military to improve the efficiency of deployment, scheduling, and transportation coordination.

Energy Division annual progress report for period ending September 30, 1993

International Nuclear Information System (INIS)

Wolff, P.P.

1994-07-01

One of 17 research divisions at Oak Ridge National Laboratory, Energy Division's mission is to provide innovative solutions to energy and related issues of national and global importance through interdisciplinary research and development. Its goals and accomplishments are described in this annual progress report for FY1993. Energy Division is committed to (1) understanding the mechanisms by which societies make choices in energy use; (2) improving society's understanding of the environmental, social, and economic implications of technological change; (3) developing and transferring energy-efficient technologies; (4) improving transportation policy and planning; (5) enhancing basic knowledge in the social sciences as related to energy and associated issues. Energy Division's expenditures in FY1993 totaled $42 million. The work was supported by the US DOE, DOD, many other federal agencies, and some private organizations. Disciplines of the 126.5 technical staff members include engineering, social sciences, physical and life sciences, and computer sciences and data systems. The division's programmatic activities cover three main areas: (1) analysis and assessment, (2) energy use and delivery technologies, and (3) transportation systems. Analysis and assessment activities involve energy and resource analysis, preparation of environmental assessments and impact statements, research on emergency preparedness, transportation analysis, and analysis of energy and environmental needs in developing countries. Energy use and delivery technologies focus on electric power systems, building equipment, building envelopes (walls, foundations, roofs, attics, and materials), and methods to improve energy efficiency in existing buildings. Transportation systems research is conducted both to improve the quality of civilian transportation and for sponsors within the US military to improve the efficiency of deployment, scheduling, and transportation coordination

The Community's research and development programme on decommissioning of nuclear installations: First annual progress report (year 1985)

International Nuclear Information System (INIS)

1986-01-01

This is the first Annual Progress Report of the European Community's 1984-88 programme of research on the decommissioning of nuclear installations. It shows the status of implementation reached on 31 December 1985. The 1984-88 programme has the following contents: A. Research and development projects concerning the following subjects: Project No 1: Long-term integrity of building and systems; Project No 2: Decontamination for decommissioning purposes; Project No 3: Dismantling techniques; Project No 4: Treatment of specific waste materials: steel, concrete and graphite; Project No 5: Large containers for radioactive waste produced in the dismantling of nuclear installations; Project No 6: Estimation of the quantities of radioactive wastes arising from the decommissioning of nuclear installations in the Community; Project No 7: Influence of installation design features on decommissioning. B. Identification of guiding principles, namely: - certain guiding principles in the design and operation of nuclear installations with a view to simplifying their subsequent decommissioning, - guiding principles in the decommissioning of nuclear installations which could form the initial elements of a Community policy in this field. C. Testing of new techniques under real conditions, within the framework of large-scale decommissioning operations undertaken in Member States. This first progress report, covering the period of putting the programme into action, describes the work to be carried out under the 27 research contracts concluded, as well as initial work performed and first results obtained

Soluble beta-amyloid precursor protein is related to disease progression in amyotrophic lateral sclerosis.

Directory of Open Access Journals (Sweden)

Petra Steinacker

Full Text Available BACKGROUND: Biomarkers of disease progression in amyotrophic lateral sclerosis (ALS could support the identification of beneficial drugs in clinical trials. We aimed to test whether soluble fragments of beta-amyloid precursor protein (sAPPα and sAPPß correlated with clinical subtypes of ALS and were of prognostic value. METHODOLOGY/PRINCIPAL FINDINGS: In a cross-sectional study including patients with ALS (N = 68 with clinical follow-up data over 6 months, Parkinson's disease (PD, N = 20, and age-matched controls (N = 40, cerebrospinal fluid (CSF levels of sAPPα a, sAPPß and neurofilaments (NfH(SMI35 were measured by multiplex assay, Progranulin by ELISA. CSF sAPPα and sAPPß levels were lower in ALS with a rapidly-progressive disease course (p = 0.03, and p = 0.02 and with longer disease duration (p = 0.01 and p = 0.01, respectively. CSF NfH(SMI35 was elevated in ALS compared to PD and controls, with highest concentrations found in patients with rapid disease progression (p<0.01. High CSF NfH(SMI3 was linked to low CSF sAPPα and sAPPß (p = 0.001, and p = 0.007, respectively. The ratios CSF NfH(SMI35/CSF sAPPα,-ß were elevated in patients with fast progression of disease (p = 0.002 each. CSF Progranulin decreased with ongoing disease (p = 0.04. CONCLUSIONS: This study provides new CSF candidate markers associated with progression of disease in ALS. The data suggest that a deficiency of cellular neuroprotective mechanisms (decrease of sAPP is linked to progressive neuro-axonal damage (increase of NfH(SMI35 and to progression of disease.

Progress report on nuclear science and technology in China (Vol.1). Proceedings of academic annual meeting of China Nuclear Society in 2009, No.8--radiation research and radiation technology

International Nuclear Information System (INIS)

2010-11-01

Progress report on nuclear science and technology in China (Vol. 1) includes 889 articles which are communicated on the first national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the eighth one, the content is about radiation study, radiation technology, isotope and nuclear agriculture

Progress on the HUPO Draft Human Proteome: 2017 Metrics of the Human Proteome Project.

Science.gov (United States)

Omenn, Gilbert S; Lane, Lydie; Lundberg, Emma K; Overall, Christopher M; Deutsch, Eric W

2017-12-01

The Human Proteome Organization (HUPO) Human Proteome Project (HPP) continues to make progress on its two overall goals: (1) completing the protein parts list, with an annual update of the HUPO draft human proteome, and (2) making proteomics an integrated complement to genomics and transcriptomics throughout biomedical and life sciences research. neXtProt version 2017-01-23 has 17 008 confident protein identifications (Protein Existence [PE] level 1) that are compliant with the HPP Guidelines v2.1 ( https://hupo.org/Guidelines ), up from 13 664 in 2012-12 and 16 518 in 2016-04. Remaining to be found by mass spectrometry and other methods are 2579 "missing proteins" (PE2+3+4), down from 2949 in 2016. PeptideAtlas 2017-01 has 15 173 canonical proteins, accounting for nearly all of the 15 290 PE1 proteins based on MS data. These resources have extensive data on PTMs, single amino acid variants, and splice isoforms. The Human Protein Atlas v16 has 10 492 highly curated protein entries with tissue and subcellular spatial localization of proteins and transcript expression. Organ-specific popular protein lists have been generated for broad use in quantitative targeted proteomics using SRM-MS or DIA-SWATH-MS studies of biology and disease.

Progress report on nuclear science and technology in China (Vol.2). Proceedings of academic annual meeting of China Nuclear Society in 2011, No.2--nuclear power sub-volume (Pt.1)

International Nuclear Information System (INIS)

2012-10-01

Progress report on nuclear science and technology in China (Vol. 2) includes 698 articles which are communicated on the second national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the second one, the content is about nuclear power (Pt.1)

S100-A9 protein in exosomes from chronic lymphocytic leukemia cells promotes NF-κB activity during disease progression.

Science.gov (United States)

Prieto, Daniel; Sotelo, Natalia; Seija, Noé; Sernbo, Sandra; Abreu, Cecilia; Durán, Rosario; Gil, Magdalena; Sicco, Estefanía; Irigoin, Victoria; Oliver, Carolina; Landoni, Ana Inés; Gabus, Raúl; Dighiero, Guillermo; Oppezzo, Pablo

2017-08-10

Chronic lymphocytic leukemia (CLL) is an incurable disease characterized by accumulation of clonal B lymphocytes, resulting from a complex balance between cell proliferation and apoptotic death. Continuous crosstalk between cancer cells and local/distant host environment is required for effective tumor growth. Among the main actors of this dynamic interplay between tumoral cells and their microenvironment are the nano-sized vesicles called exosomes. Emerging evidence indicates that secretion, composition, and functional capacity of exosomes are altered as tumors progress to an aggressive phenotype. In CLL, no data exist exploring the specific changes in the proteomic profile of plasma-derived exosomes from patients during disease evolution. We hereby report for the first time different proteomic profiles of plasma exosomes, both between indolent and progressive CLLs as well as within the individual patients at the onset of disease and during its progression. Next, we focus on the changes of the exosome protein cargoes, which are found exclusively in patients with progressive CLL after disease progression. The alterations in the proteomic cargoes underline different networks specific for leukemia progression related to inflammation, oxidative stress, and NF-κB and phosphatidylinositol 3-kinase/AKT pathway activation. Finally, our results suggest a preponderant role for the protein S100-A9 as an activator of the NFκB pathway during CLL progression and suggest that the leukemic clone can generate an autoactivation loop through S100-A9 expression, NF-κB activation, and exosome secretion. Collectively, our data propose a new pathway for NF-κB activation in CLL and highlight the importance of exosomes as extracellular mediators promoting tumor progression in CLL. © 2017 by The American Society of Hematology.

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.2--uranium mining and metallurgy sub-volume

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 48 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the second one, the content is about uranium mining and metallurgy sub-volume

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.3--nuclear power sub-volume (Pt.2)

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 86 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the third one, the content is about nuclear power sub-volume (Pt.2)

Progress report on nuclear science and technology in China (Vol.1). Proceedings of academic annual meeting of China Nuclear Society in 2009, No.2--nuclear power sub-volume (Pt.1)

International Nuclear Information System (INIS)

2010-11-01

Progress report on nuclear science and technology in China (Vol. 1) includes 889 articles which are communicated on the first national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the second one, the content is about uranium mining, uranium metallurgy and nuclear power.

Progress report on nuclear science and technology in China (Vol.1). Proceedings of academic annual meeting of China Nuclear Society in 2009, No.2--uranium mining and metallurgy sub-volume

International Nuclear Information System (INIS)

2010-11-01

Progress report on nuclear science and technology in China (Vol. 1) includes 889 articles which are communicated on the first national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the second one, the content is about uranium mining, uranium metallurgy and nuclear power.

Radiochemistry Division: annual progress report: 1987

International Nuclear Information System (INIS)

1989-01-01

The progress of Research and Development (R and D) activities during the year 1987 are reported in the form of summaries, which are presented under the headings (1) Actinide Chemistry, (2) Nuclear Chemistry, and (3) Spectroscopy. Microwave absorption studies of the high Tsub(c) oxide superconductor YBa 2 Cu 3 Osub(7-x) using electron paramagnetic resonance techniques are the new feature during the report year. Radioanalytical services and radiation sources in the form of electrodeposited sources or standard soluti ons were also given to the other Divisions, other units of the Department of Atomic Energy, and other organisations in the country. A list of papers by the members of the Division published in various journals and presented at various symposia, conferences etc. is given at the end of the report. (M.G.B.). refs., 51 tabs., 33 figs

Annual Progress Report on the Development of Waste Tank Leak Monitoring and Detection and Mitigation Activities in Support of M-45-08

International Nuclear Information System (INIS)

DEFIGH PRICE, C.

2000-01-01

Milestone M-45-09E of the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement or TPA) [TPA 1996] requires submittal of an annual progress report on the development of waste tank leak detection, monitoring, and mitigation (LDMM) activities associated with the retrieval of waste from single-shell tanks (SSTs). This report details progress for fiscal year 2000, building on the current LDMM strategy and including discussion of technologies, applications, cost, schedule, and technical data. The report also includes discussion of demonstrations conducted and recommendations for additional testing. Tri-Party Agreement Milestones M-45-08A and M-45-08B required design and demonstration of LDMM systems for initial retrieval of SST waste. These specific milestones have recently been deleted as part of the M-45-00A change package. Future LDMM development work has been incorporated into specific technology demonstration milestones and SST waste retrieval milestones in the M-45-03 and M-45-05 milestone series

Annual Report 1979

International Nuclear Information System (INIS)

1980-01-01

This annual report from the Netherlands Centre for Energy Research, includes the progress made in the five main research areas: fission energy, nuclear fusion and superconductivity, combustion energy (including environmental research), current energy and non-energetic applications of nuclear fission. Studies performed by the Energy Study Centrum, a department within ECN, and the Bureau for Energy Research Projects are described. A financial report is presented and a list of publications included. (C.F.)

Significance of Selective Predation and Development of Prey Protection Measures for Juvenile Salmonids in the Columbia and Snake River Reservoirs: Annual Progress Report, February 1991-February 1992.

Energy Technology Data Exchange (ETDEWEB)

Poe, Thomas P.

1992-12-31

This document is the 1991 annual report of progress for the Bonneville Power Administration (BPA) research Project conducted by the US Fish and Wildlife Service (FWS). Our approach was to present the progress achieved during 1991 in a series of separate reports for each major project task. Each report is prepared in the format of a scientific paper and is able to stand alone, whatever the state of progress or completion. This project has two major goals. One is to understand the significance of selective predation and prey vulnerability by determining if substandard juvenile salmonids (dead, injured, stressed, diseased, or naive) are more vulnerable to predation by northern squawfish, than standard or normal juvenile salmonids. The second goal is to develop and test prey protection measures to control predation on juvenile salmonids by reducing predator-smolt encounters or predator capture efficiency.

Experimental studies on the Auburn Torsatron: Annual progress report

International Nuclear Information System (INIS)

Gandy, R.F.; Swanson, D.G.

1988-10-01

This paper discusses research programs in progress on the Auburn Torsatron. Topic areas covered are: ICR heating results; Compact Auburn Torsatron design; Compact Auburn Torsatron construction; and collaborations

Temporal expression profiling of plasma proteins reveals oxidative stress in early stages of Type 1 Diabetes progression

International Nuclear Information System (INIS)

Liu, Chih-Wei; Bramer, Lisa; Computational Modeling); Webb-Robertson, Bobbie-Jo; Computational Modeling); Waugh, Kathleen; Rewers, Marian J.; Zhang, Qibin; Biochemistry)

2017-01-01

We report that blood markers other than islet autoantibodies are greatly needed to indicate the pancreatic beta cell destruction process as early as possible, and more accurately reflect the progression of Type 1 Diabetes Mellitus (T1D). To this end, a longitudinal proteomic profiling of human plasma using TMT-10plex-based LC-MS/MS analysis was performed to track temporal proteomic changes of T1D patients (n = 11) across 9 serial time points, spanning the period of T1D natural progression, in comparison with those of the matching healthy controls (n = 10). To our knowledge, the current study represents the largest (> 2000 proteins measured) longitudinal expression profiles of human plasma proteome in T1D research. By applying statistical trend analysis on the temporal expression patterns between T1D and controls, and Benjamini-Hochberg procedure for multiple-testing correction, 13 protein groups were regarded as having statistically significant differences during the entire follow-up period. Moreover, 16 protein groups, which play pivotal roles in response to oxidative stress, have consistently abnormal expression trend before seroconversion to islet autoimmunity. Importantly, the expression trends of two key reactive oxygen species-decomposing enzymes, Catalase and Superoxide dismutase were verified independently by ELISA.

2010 Annual Progress Report: DOE Hydrogen Program

Energy Technology Data Exchange (ETDEWEB)

2011-02-01

In the past year, the DOE Hydrogen Program (the Program) made substantial progress toward its goals and objectives. The Program has conducted comprehensive and focused efforts to enable the widespread commercialization of hydrogen and fuel cell technologies in diverse sectors of the economy. With emphasis on applications that will effectively strengthen our nation's energy security and improve our stewardship of the environment, the Program engages in research, development, and demonstration of critical improvements in the technologies. Highlights of the Program's accomplishments can be found in the sub-program chapters of this report.

Geothermal Energy Development annual report 1979

Energy Technology Data Exchange (ETDEWEB)

1980-08-01

This report is an exerpt from Earth Sciences Division Annual Report 1979 (LBL-10686). Progress in thirty-four research projects is reported including the following area: geothermal exploration technology, geothermal energy conversion technology, reservoir engineering, and geothermal environmental research. Separate entries were prepared for each project. (MHR)

Fiscal year 1995 progress in implementing Section 120 of the Comprehensive Environmental Response, Compensation, and Liability Act. Ninth annual report to Congress

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-09-01

Congress passed the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) (Public Law 96-510), commonly known as Superfund, in 1980. The Superfund Amendments and Reauthorization Act (SARA) which amended CERCLA in 1986, added Section 120 regarding the cleanup of contaminated sites at Federal facilities. Under Section 120(e)(5) of CERCLA, each department, agency, or instrumentality of the Federal government responsible for compliance with Section 120 must submit an annual report to Congress concerning its progress in implementing the requirements of Section 120. The report must include information on the progress in reaching Interagency Agreements (IAGs), conducting Remedial Investigation and Feasibility Studies (RI/FSs), and performing remedial action. Federal agencies that own or operate facilities on the National priorities List (NPL) are required to begin an RI/FS for these facilities within 6 months after being placed on the NPL. Remediation of these facilities is addressed in an IAG between the Federal agency, the US Environmental Protection Agency (EPA), and in some instances the state within which the facility is located. This report provides the status of ongoing activities being performed in support of CERCLA Section 120 at DOE facilities. This includes activities conducted to reach IAGs and progress in conducting remedial actions.

Fiscal year 1995 progress in implementing Section 120 of the Comprehensive Environmental Response, Compensation, and Liability Act. Ninth annual report to Congress

International Nuclear Information System (INIS)

1996-09-01

Congress passed the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) (Public Law 96-510), commonly known as Superfund, in 1980. The Superfund Amendments and Reauthorization Act (SARA) which amended CERCLA in 1986, added Section 120 regarding the cleanup of contaminated sites at Federal facilities. Under Section 120(e)(5) of CERCLA, each department, agency, or instrumentality of the Federal government responsible for compliance with Section 120 must submit an annual report to Congress concerning its progress in implementing the requirements of Section 120. The report must include information on the progress in reaching Interagency Agreements (IAGs), conducting Remedial Investigation and Feasibility Studies (RI/FSs), and performing remedial action. Federal agencies that own or operate facilities on the National priorities List (NPL) are required to begin an RI/FS for these facilities within 6 months after being placed on the NPL. Remediation of these facilities is addressed in an IAG between the Federal agency, the US Environmental Protection Agency (EPA), and in some instances the state within which the facility is located. This report provides the status of ongoing activities being performed in support of CERCLA Section 120 at DOE facilities. This includes activities conducted to reach IAGs and progress in conducting remedial actions

Annual Report 2006

International Nuclear Information System (INIS)

Chmielewska, D.; Infeld, E.; Zupranski, P.

2007-06-01

The ''Annual Report 2006'' describes activities of Andrzej Soltan Institute for Nuclear Studies in 2006. Report consists in general two parts. First consists of general information about location, management, scientific council, personnel, financial support and conferences while the second one the scientific activity of Institute. This part is divided into subsections which present progress in research of the Institut Departments and Establishments. A Foreword to report written by Director of the Institute Grzegorz Wrochna is also given

Annual Report 2006

Energy Technology Data Exchange (ETDEWEB)

Chmielewska, D; Infeld, E; Zupranski, P [The Andrzej Soltan Institute for Nuclear Studies, Swierk-Otwock (Poland)

2007-06-15

The ''Annual Report 2006'' describes activities of Andrzej Soltan Institute for Nuclear Studies in 2006. Report consists in general two parts. First consists of general information about location, management, scientific council, personnel, financial support and conferences while the second one the scientific activity of Institute. This part is divided into subsections which present progress in research of the Institut Departments and Establishments. A Foreword to report written by Director of the Institute Grzegorz Wrochna is also given.

Annual Report 2005

Energy Technology Data Exchange (ETDEWEB)

Chmielewska, D; Infeld, E; Zupranski, P [The Andrzej Soltan Institute for Nuclear Studies, Swierk-Otwock (Poland)

2006-06-15

The ''Annual Report 2005'' describes activities of Andrzej Soltan Institute for Nuclear Studies in 2005. Report consists in general two parts. First consists of general information about location, management, scientific council, personnel financial support and conferences while the second one the scientific activity of Institute. This part is divided into subsections which present progress in research of the Institut Departments and Establishments. A Foreword to report written by Director of the Institute prof. Ziemowit Sujkowski is also given.

Annual Report 2005

International Nuclear Information System (INIS)

Chmielewska, D.; Infeld, E.; Zupranski, P.

2006-06-01

The ''Annual Report 2005'' describes activities of Andrzej Soltan Institute for Nuclear Studies in 2005. Report consists in general two parts. First consists of general information about location, management, scientific council, personnel financial support and conferences while the second one the scientific activity of Institute. This part is divided into subsections which present progress in research of the Institut Departments and Establishments. A Foreword to report written by Director of the Institute prof. Ziemowit Sujkowski is also given

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.7--nuclear fusion and plasma physics sub-volume

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 22 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the seventh one, the content is about nuclear fusion and plasma physics sub-volume

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.9--nuclear technology applied in industry sub-volume

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 35 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the ninth one, the content is about nuclear technology applied in industry sub-volume

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.8--radiation research and its application sub-volume

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 12 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the eighth one, the content is about radiation research and its application sub-volume

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.4--Nuclear chemistry and radiation chemistry sub-volume

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 24 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the fourth one, the content is about Nuclear chemistry and radiation chemistry sub-volume

Endothelial dysfunction and low-grade inflammation and the progression of retinopathy in Type 2 diabetes

DEFF Research Database (Denmark)

Spijkerman, Annemieke M W; Gall, Mari-Anne; Tarnow, L

2007-01-01

AIMS: To study whether microalbuminuria, endothelial dysfunction and low-grade inflammation are associated with the presence and progression of diabetic retinopathy. METHODS: Patients with Type 2 diabetes (n = 328) attending a diabetes clinic were followed for 10 years and examined annually during.......65 (1.21-2.25). CONCLUSIONS: In this population of patients with Type 2 diabetes who attended a diabetes clinic, there was some evidence for a role of endothelial dysfunction in the progression of retinopathy. We could not demonstrate a role for low-grade inflammation. Our study emphasizes......E-selectin), and soluble vascular cell adhesion molecule 1) and inflammatory activity (C-reactive protein and fibrinogen) were determined. RESULTS: The prevalence of retinopathy was 33.8%. The median diabetes duration at baseline was 7 years (interquartile range 2-12 years). The highest tertiles of baseline urinary...

Radiochemistry Division annual progress report : 1990

International Nuclear Information System (INIS)

Iyer, R.H.

1992-01-01

This progress report provides an account of the research and development activities of the Radiochemistry Division during the year 1990 in the areas of nuclear chemistry, actinide chemistry and spectroscopy. The main area of work in nuclear chemistry is centered around the fission process induced by reactor neutrons, and light and heavy ions on actinides and low Z (Z<80) elements. Actinide chemistry research is concerned mostly with extraction, complexation and separation of actinide ions from aqueous media using a variety of organic reagents under different experimental conditions. Spectroscopic studies include development and optimisation of chemical/analytical methods for separation and determination of trace metallic impurities and rare earths in fuel materials and EPR and microwave studies on several compounds to understand their superconducting, structural and magnetic properties. A list of publications by the scientific staff of the Division during 1990 is also given in the report. (author). 45 figs., 44 tabs

Targeting ECM Disrupts Cancer Progression

DEFF Research Database (Denmark)

Venning, Freja A; Wullkopf, Lena; Erler, Janine T

2015-01-01

, the extracellular matrix (ECM). Many ECM proteins are significantly deregulated during the progression of cancer, causing both biochemical and biomechanical changes that together promote the metastatic cascade. In this review, the influence of several ECM proteins on these multiple steps of cancer spread...... is summarized. In addition, we highlight the promising (pre-)clinical data showing benefits of targeting these ECM macromolecules to prevent cancer progression....

DESY. Scientific annual report 2003

International Nuclear Information System (INIS)

2004-01-01

In the following the main progresses at DESY in the fields accelerator development, elementary-particle physics, research with photons and particle astrophysics, as well as the accelerator development are briefly presented. More detailed descriptions of the events and important developments of the year 2003 are found in the following chapters of the present annual report [de

Linking Knowledge Worldwide Annual Report, 1998.

Science.gov (United States)

Netherlands Organisation for International Cooperation in Higher Education, The Hague.

This annual report discusses the work and progress of the Netherlands Organization for International Cooperation in Higher Education (Nuffic), which is devoted to achieving increased intercultural understanding, an equitable distribution of knowledge and infrastructure over all parts of the world, and improvement in the quality of education.…

Health in Transportation Working Group 2016 Annual Report

Science.gov (United States)

2017-06-30

The Health in Transportation Working Group 2016 Annual Report provides an overview of the Working Groups activities and accomplishments in 2016, summarizes other USDOT health-related accomplishments, and documents its progress toward the recommend...

Annual report of waste generation and pollution prevention progress 1998; ANNUAL

International Nuclear Information System (INIS)

NONE

1999-01-01

This seventh Annual Report presents and analyzes DOE Complex-wide waste generation and pollution prevention activities at 45 reporting sites from 1993 through 1998. This section summarizes Calendar Year 1998 Complex-wide waste generation and pollution prevention accomplishments. More detailed information follows this section in the body of the Report. In May 1996, the Secretary of Energy established a 50 percent Complex-Wide Waste Reduction Goal (relative to the 1993 baseline) for routine operations radioactive, mixed, and hazardous waste generation, to be achieved by December31, 1999. DOE has achieved its Complex-Wide Waste Reduction Goals for routine operations based upon a comparison of 1998 waste generation to the 1993 baseline. Excluding sanitary waste, routine operations waste generation decreased 67 percent overall from 1993 to 1998. However, for the first time since 1994, the total amount of materials recycled by the Complex decreased from 109,600 metric tons in 1997 to 92,800 metric tons in 1998. This decrease is attributed to the fact that in 1997, several large ''one-time only'' recycling projects were conducted throughout the Complex. In order to demonstrate commitment to DOE's Complex-wide recycling goal, it is important for sites to identify all potential large-scale recycling/reuse opportunities

Idas, a Novel Phylogenetically Conserved Geminin-related Protein, Binds to Geminin and Is Required for Cell Cycle Progression*

Science.gov (United States)

Pefani, Dafni-Eleutheria; Dimaki, Maria; Spella, Magda; Karantzelis, Nickolas; Mitsiki, Eirini; Kyrousi, Christina; Symeonidou, Ioanna-Eleni; Perrakis, Anastassis; Taraviras, Stavros; Lygerou, Zoi

2011-01-01

Development and homeostasis of multicellular organisms relies on an intricate balance between cell proliferation and differentiation. Geminin regulates the cell cycle by directly binding and inhibiting the DNA replication licensing factor Cdt1. Geminin also interacts with transcriptional regulators of differentiation and chromatin remodelling factors, and its balanced interactions are implicated in proliferation-differentiation decisions during development. Here, we describe Idas (Idas being a cousin of the Gemini in Ancient Greek Mythology), a previously uncharacterised coiled-coil protein related to Geminin. We show that human Idas localizes to the nucleus, forms a complex with Geminin both in cells and in vitro through coiled-coil mediated interactions, and can change Geminin subcellular localization. Idas does not associate with Cdt1 and prevents Geminin from binding to Cdt1 in vitro. Idas depletion from cells affects cell cycle progression; cells accumulate in S phase and are unable to efficiently progress to mitosis. Idas protein levels decrease in anaphase, whereas its overexpression causes mitotic defects. During development, we show that Idas exhibits high level expression in the choroid plexus and the cortical hem of the mouse telencephalon. Our data highlight Idas as a novel Geminin binding partner, implicated in cell cycle progression, and a putative regulator of proliferation-differentiation decisions during development. PMID:21543332

Annual progress report, July 1, 1979-June 30, 1980

International Nuclear Information System (INIS)

1980-01-01

Research progress is reported for the year 1979-1980. The report is divided into sections dealing individually with the divisions of Biomolecular and Cellular Science, Environmental Biology, and Nuclear Medicine. The sections have been individually entered into EDB

Improved Barriers to Turbine Engine Fragments: Final Annual Report

National Research Council Canada - National Science Library

Shockey, Donald

2002-01-01

This final annual technical report describes the progress rnade during year 4 of the SPI International Phase II effort to develop a computational capability for designing lightweight fragment barriers...

IMP annual report, 1988 (January-December)

International Nuclear Information System (INIS)

1990-06-01

The research activities of Institute of Modern Physics, Academia Sinica of China, during the year of 1988, was summarized in this annual report. A highlight of these activities during the year was the progress of HIRFL project. HIRFL was delivered successfully 50 MeV/A 12 C beam on december 12, 1988. The scientific paper contained in this annual report are concerning to the fundamental scientific research, mainly nuclear physics. The development on experimental technique and the research on application of nuclear techniques have been reported also. It divided into ten parts, more than ninety pieces of short notes were presented

Annual progress report, July 1, 1979-June 30, 1980

Energy Technology Data Exchange (ETDEWEB)

1980-01-01

Research progress is reported for the year 1979-1980. The report is divided into sections dealing individually with the divisions of Biomolecular and Cellular Science, Environmental Biology, and Nuclear Medicine. The sections have been individually entered into EDB. (ACR)

Role of zein proteins in structure and assembly of protein bodies and endosperm texture. Progress report and appendix 1 - preliminary data

Energy Technology Data Exchange (ETDEWEB)

Larkins, B.

1997-05-01

Although funding for this project was initiated less than two years ago, we have made significant progress with our research objectives. We have cloned the gene responsible for the fl2 mutation. In fl2, the mutant phenotype appears to result from a defective signal peptide in an alpha-zein protein. As a consequence, the signal peptide remains attached when the protein accumulates in the protein body. A mutation like fl2 could explain other semidominant and dominant opaque mutants on the basis of abnormal zein polypeptides. A manuscript describing the research that led to the cloning of fl2 is in press, and a second manuscript on the characterization of this gene has been prepared for publication. We found that increased amounts of the 27-kD gamma-zein protein enlarge the proportion of vitreous endosperm and increases the hardness of o2 mutants. This protein also enhances these properties in wild type seeds. The mechanism by which the gamma-zein protein brings about these changes is unclear, and is under investigation. We have found and characterized several mutants that reduce gamma-zein synthesis. The mutations do not significantly affect synthesis of any other type of zein protein. They appear to create an opaque phenotype by reducing the number rather than the size of protein bodies. Interestingly, the mutant seeds fail to germinate. A manuscript describing one of these mutants, o15, has been prepared for publication. We have created a number of transgenic tobacco plants that can produce alpha-, beta-, gamma(27-kD)-, or delta-zeins, as well as combinations of these proteins. Analysis of seeds from these plants and crosses of these plants has shown that tobacco endosperm can serve as a heterologous system to study zein interactions. We have obtained evidence that interactions between alpha- and gamma-zein proteins are required for stable accumulation of alpha-zeins in the endosperm. These and other preliminary results are illustrated in Appendix 1.

Annual Report 2007

Energy Technology Data Exchange (ETDEWEB)

Chmielewska, D; Infeld, E; Zupranski, P [The Andrzej Soltan Institute for Nuclear Studies, Swierk-Otwock (Poland)

2008-07-01

The ''Annual Report 2007'' describes activities of Andrzej Soltan Institute for Nuclear Studies in 2007. Report consists of two parts. First one consist of of general information about location, management, scientific council, personnel, financial support and conferences while the second one describes the scientific activity of Institute. This part is divided into subsections which present progress in research of the Institut Departments and Establishments. A Foreword to all report written by Director of the Institute prof. Grzegorz Wrochna is also given.

Annual Report 2007

International Nuclear Information System (INIS)

Chmielewska, D.; Infeld, E.; Zupranski, P.

2008-01-01

The ''Annual Report 2007'' describes activities of Andrzej Soltan Institute for Nuclear Studies in 2007. Report consists of two parts. First one consist of of general information about location, management, scientific council, personnel, financial support and conferences while the second one describes the scientific activity of Institute. This part is divided into subsections which present progress in research of the Institut Departments and Establishments. A Foreword to all report written by Director of the Institute prof. Grzegorz Wrochna is also given

Progress report on nuclear science and technology in China (Vol.2). Proceedings of academic annual meeting of China Nuclear Society in 2011, No.10--nuclear technology economy and management modernization sub-volume

International Nuclear Information System (INIS)

2012-10-01

Progress report on nuclear science and technology in China (Vol. 2) includes 698 articles which are communicated on the second national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the tenth one, the content is about nuclear technology economy and management modernization

Progress report on nuclear science and technology in China (Vol.2). Proceedings of academic annual meeting of China Nuclear Society in 2011, No.7--Nuclear electronics and nuclear detection technology sub-volume

International Nuclear Information System (INIS)

2012-10-01

Progress report on nuclear science and technology in China (Vol. 2) includes 698 articles which are communicated on the second national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the seventh one, the content is about Nuclear electronics and nuclear detection technology

Progressive cerebral atrophy in neuromyelitis optica.

Science.gov (United States)

Warabi, Yoko; Takahashi, Toshiyuki; Isozaki, Eiji

2015-12-01

We report two cases of neuromyelitis optica patients with progressive cerebral atrophy. The patients exhibited characteristic clinical features, including elderly onset, secondary progressive tetraparesis and cognitive impairment, abnormally elevated CSF protein and myelin basic protein levels, and extremely highly elevated serum anti-AQP-4 antibody titer. Because neuromyelitis optica pathology cannot switch from an inflammatory phase to the degenerative phase until the terminal phase, neuromyelitis optica rarely appears as a secondary progressive clinical course caused by axonal degeneration. However, severe intrathecal inflammation and massive destruction of neuroglia could cause a secondary progressive clinical course associated with cerebral atrophy in neuromyelitis optica patients. © The Author(s), 2015.

Environmental Management Science Program awards. Fiscal year 1997 annual progress report

Energy Technology Data Exchange (ETDEWEB)

Simmons, A. [ed.; Benner, W.H.; DePaolo, D.J.; Faybishenko, B.; Majer, E.L.; Pallavicini, M.; Russo, R.E.; Shultz, P.G.; Wan, J.

1997-10-01

Lawrence Berkeley National Laboratory was awarded eight Environmental Management Science Program (EMSP) research grants in Fiscal Year 1996. This report summarizes the progress of each grant in addressing significant DOE site cleanup issues after completion of the first year of research. The technical progress made to date in each of the research projects is described in greater detail in individual progress reports. The focus of the research projects covers a diversity of areas relevant to site cleanup, including bioremediation, health effects, characterization, and mixed waste. Some of the projects cut across a number of focus areas. Three of the projects are directed toward characterization and monitoring at the Idaho National Engineering and Environmental Laboratory, as a test case for application to other sites.

Environmental Management Science Program awards. Fiscal year 1997 annual progress report

International Nuclear Information System (INIS)

Simmons, A.; Benner, W.H.; DePaolo, D.J.; Faybishenko, B.; Majer, E.L.; Pallavicini, M.; Russo, R.E.; Shultz, P.G.; Wan, J.

1997-10-01

Lawrence Berkeley National Laboratory was awarded eight Environmental Management Science Program (EMSP) research grants in Fiscal Year 1996. This report summarizes the progress of each grant in addressing significant DOE site cleanup issues after completion of the first year of research. The technical progress made to date in each of the research projects is described in greater detail in individual progress reports. The focus of the research projects covers a diversity of areas relevant to site cleanup, including bioremediation, health effects, characterization, and mixed waste. Some of the projects cut across a number of focus areas. Three of the projects are directed toward characterization and monitoring at the Idaho National Engineering and Environmental Laboratory, as a test case for application to other sites

Progress Report 1994

International Nuclear Information System (INIS)

1995-01-01

This document is the 1994 annual progress report of the CEA-Direction of Waste Management (DGD). It comprises four chapters. The first chapter is a general presentation of radioactive wastes, of the management of liquid effluents, solid wastes, sealed sources, of the relations with the ANDRA (The French Agency for the Management of Radioactive Wastes), and of the research and development studies in progress for the improvement of waste management. The second chapter concerns the spent fuels and their reprocessing, in particular AGR and PWR type reactor fuels, the ''Caramel'' fuel from Osiris reactor and the cover elements from the Rapsodie reactor core. The long time storage of ancient fuels is also discussed. The third chapter concerns the dismantling of decommissioned installations, the actions in progress and the planning of dismantling actions up to the year 2000. Chapter four is devoted to the management of wastes from the Direction of Military Applications (DAM), the actions in progress in the different DAM centers and the cleansing projects at Marcoule plant. (J.S.). 5 figs., 28 tabs., 21 photos., 3 appendix

Fiscal year 1996 progress in implementing Section 120 of the Comprehensive Environmental Response, Compensation, and Liability Act. Tenth annual report to Congress

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-12-01

Congress passed the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) (Public Law 96-510), commonly known as Superfund, in 1980. The Superfund Amendments and Reauthorization Act (SARA) (Public Law 99-499), which amended CERCLA in 1986, added Section 120 regarding the cleanup of contaminated sites at Federal facilities. Under Section 120(e)(5) of CERCLA, each department, agency, or instrumentality of the Federal government responsible for compliance with Section 120 must submit an annual report to Congress concerning its progress in implementing the requirements of Section 120. The report must include information on the progress in reaching Interagency Agreements (IAGs), conducting remedial investigation and feasibility studies (RI/FSs), and performing remedial actions. Federal agencies that own or operate facilities on the National Priorities List (NPL) are required to begin an RI/FS for these facilities within 6 months after being placed on the NPL. Remediation of these facilities is addressed in an IAG between the Federal agency, the US Environmental Protection Agency (EPA), and in some instances the state within which the facility is located.

Longitudinal analysis of progression in glaucoma using spectral-domain optical coherence tomography.

Science.gov (United States)

Wessel, Julia M; Horn, Folkert K; Tornow, Ralf P; Schmid, Matthias; Mardin, Christian Y; Kruse, Friedrich E; Juenemann, Anselm G; Laemmer, Robert

2013-05-01

To compare the longitudinal loss of RNFL thickness measurements by SD-OCT in healthy individuals and glaucoma patients with or without progression concerning optic disc morphology. A total of 62 eyes, comprising 38 glaucomatous eyes with open angle glaucoma and 24 healthy controls, were included in the study (Erlangen Glaucoma Registry, NTC00494923). All patients were investigated annually over a period of 3 years by Spectralis SD-OCT measuring peripapillary RNFL thickness. By masked comparative analysis of photographs, the eyes were classified into nonprogressive and progressive glaucoma cases. Longitudinal loss of RNFL thickness was compared with morphological changes of optic disc morphology. Mixed model analysis of annual OCT scans revealed an estimated annual decrease of the RNFL thickness by 2.12 μm in glaucoma eyes with progression, whereas glaucoma eyes without progression in optic disc morphology lost 1.18 μm per year in RNFL thickness (P = 0.002). The rate of change in healthy eyes was 0.60 μm and thereby also significantly lower than in glaucoma eyes with progression (P < 0.001). The intrasession variability of three successive measurements without head repositioning was 1.5 ± 0.7 μm. The loss of mean RNFL thickness exceeded the intrasession variability in 60% of nonprogressive eyes, and in 85% of progressive eyes after 3 years. LONGITUDINAL MEASUREMENTS OF RNFL THICKNESS USING SD-OCT SHOW A MORE PRONOUNCED REDUCTION OF RNFL THICKNESS IN PATIENTS WITH PROGRESSION COMPARED WITH PATIENTS WITHOUT PROGRESSION IN GLAUCOMATOUS OPTIC DISC CHANGES. (www.clinicaltrials.gov number, NTC00494923.).

FY 2012 Lightweight Materials Annual Report

Energy Technology Data Exchange (ETDEWEB)

None

2013-04-15

The FY 2012 Annual Progress Report for Lightweight Materials provides a detailed description of the activities and technical accomplishments which focuses on the development and validation of advanced materials and manufacturing technologies to significantly reduce light and heavy duty vehicle weight without compromising other attributes such as safety, performance, recyclability, and cost.

Fuel Chemistry Division annual progress report for 1990

International Nuclear Information System (INIS)

Vaidyanathan, R.

1993-01-01

The progress report gives brief descriptions of the various activities of the Fuel Chemistry Division of Bhabha Atomic Research Centre, Bombay for the year 1990. The descriptions of activities are arranged under the headings: Fuel Development Chemistry, Chemistry of Actinides, Quality Control of Nuclear Fuels, and studies related to Nuclear Materials Accounting. At the end of the report, a list of papers published in journals and presented at various conferences/symposia is also given. (author). 7 figs., 52 tabs

Fuel Chemistry Division: annual progress report for 1988

International Nuclear Information System (INIS)

Vaidyanathan, S.

1991-01-01

The progress report gives the brief descriptions of various activites of the Fuel Chemistry Division of Bhabha Atomic Research Centre, Bombay for the year 1988. The descriptions of activities are arranged under the headings: Fuel Development Chemistry of Actinides, Quality Control of Fuel, and Studies related to Nuclear Material Accounting. At the end of report, a list of publications published in journals and papers presented at various conferences/symposia during 1988 is given. (author). 13 figs., 61 tabs

High Energy Physics Group. Annual progress report, fiscal year 1983

International Nuclear Information System (INIS)

1983-01-01

Perhaps the most significant progress during the past twelve months of the Hawaii experimental program, aside from publication of results of earlier work, has been the favorable outcome of several important proposals in which a substantial fraction of our group is involved: the Mark II detector as first-up at the SLC, and DUMAND's Stage I approval, both by DOE review panels. When added to Fermilab approval of two neutrino bubble-chamber experiments at the Tevatron, E632 and E646, the major part of the Hawaii experimental program for the next few years is now well determined. Noteworthy in the SLAC/SLC/Mark II effort is the progress made in developing silicon microstrip detectors with microchip readout. Results from the IMB(H) proton decay experiment at the Morton Salt Mine, although not detecting proton decay, set the best lower limit on the proton's lifetime. Similarly the Very High Energy Gamma Ray project is closely linked with DUMAND, at least in principle, since these gammas are expected to arise from pi-zero decay, while the neutrinos come from charged meson decay. Some signal has been seen from Cygnus X-3, and other candidates are being explored. Preparations for upgrading the Fermilab 15' Bubble Chamber have made substantial progress. Sections of the Progress Report are devoted to VAX computer system improvements, other hardware and software improvements, travel in support of physics experiments, publications and other public reports, and last analysis of data still being gleaned from experimental data taken in years past (PEP-14 and E546, E388). High energy physics theoretical research is briefly described

CKD Progression and Mortality among Hispanics and Non-Hispanics.

Science.gov (United States)

Fischer, Michael J; Hsu, Jesse Y; Lora, Claudia M; Ricardo, Ana C; Anderson, Amanda H; Bazzano, Lydia; Cuevas, Magdalena M; Hsu, Chi-Yuan; Kusek, John W; Renteria, Amada; Ojo, Akinlolu O; Raj, Dominic S; Rosas, Sylvia E; Pan, Qiang; Yaffe, Kristine; Go, Alan S; Lash, James P

2016-11-01

Although recommended approaches to CKD management are achieved less often in Hispanics than in non-Hispanics, whether long-term outcomes differ between these groups is unclear. In a prospective longitudinal analysis of participants enrolled into the Chronic Renal Insufficiency Cohort (CRIC) and Hispanic-CRIC Studies, we used Cox proportional hazards models to determine the association between race/ethnicity, CKD progression (50% eGFR loss or incident ESRD), incident ESRD, and all-cause mortality, and linear mixed-effects models to assess differences in eGFR slope. Among 3785 participants, 13% were Hispanic, 43% were non-Hispanic white (NHW), and 44% were non-Hispanic black (NHB). Over a median follow-up of 5.1 years for Hispanics and 6.8 years for non-Hispanics, 27.6% of all participants had CKD progression, 21.3% reached incident ESRD, and 18.3% died. Hispanics had significantly higher rates of CKD progression, incident ESRD, and mean annual decline in eGFR than did NHW (P<0.05) but not NHB. Hispanics had a mortality rate similar to that of NHW but lower than that of NHB (P<0.05). In adjusted analyses, the risk of CKD progression did not differ between Hispanics and NHW or NHB. However, among nondiabetic participants, compared with NHB, Hispanics had a lower risk of CKD progression (hazard ratio, 0.61; 95% confidence interval, 0.39 to 0.95) and incident ESRD (hazard ratio, 0.50; 95% confidence interval, 0.30 to 0.84). At higher levels of urine protein, Hispanics had a significantly lower risk of mortality than did non-Hispanics (P<0.05). Thus, important differences in CKD progression and mortality exist between Hispanics and non-Hispanics and may be affected by proteinuria and diabetes. Copyright © 2016 by the American Society of Nephrology.

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.7--pulse power technology and its application sub-volume

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 18 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the seventh one, the content is about pulse power technology and its application sub-volume

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.7--Nuclear electronics and nuclear detection technology sub-volume

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 57 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the seventh one, the content is about Nuclear electronics and nuclear detection technology sub-volume

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.10--nuclear technology economy and management modernization sub-volume

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 18 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the tenth one, the content is about nuclear technology economy and management modernization sub-volume

Progress report on nuclear science and technology in China (Vol.2). Proceedings of academic annual meeting of China Nuclear Society in 2011, No.7--pulse power technology and its application sub-volume

International Nuclear Information System (INIS)

2012-10-01

Progress report on nuclear science and technology in China (Vol. 2) includes 698 articles which are communicated on the second national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the seventh one, the content is about Nuclear electronics and pulse power technology and its application

Annual report of waste generation and pollution prevention progress 1995

International Nuclear Information System (INIS)

1997-02-01

This fourth Annual Report presents and analyzes 1995 DOE complex-wide waste generation and pollution prevention activities at 40 reporting sites in 25 States, and trends DOE waste generation from 1991 through 1995. DOE has established a 50% reduction goal (relative to the 1993 baseline) for routine operations radioactive and hazardous waste generation, due by December 31, 1999. Routine operations waste generation decreased 37% from 1994 to 1995, and 43% overall from 1993--1995

International VLBI Service for Geodesy and Astrometry 2007 Annual Report

Science.gov (United States)

Behrend, D. (Editor); Baver, K. D. (Editor)

2008-01-01

This volume of reports is the 2007 Annual Report of the International VLBI Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the components of IVS. The 2007 Annual Report documents the work of these IVS components over the period January 1, 2007 through December 31, 2007. The reports document changes, activities, and progress of the IVS. The entire contents of this Annual Report also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/ar2007.

International VLBI Service for Geodesy and Astrometry 2008 Annual Report

Science.gov (United States)

Behrend, Dirk; Baver, Karen D.

2009-01-01

This volume of reports is the 2008 Annual Report of the International VLBI Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the components of IVS. The 2008 Annual Report documents the work of these IVS components over the period January 1, 2008 through December 31, 2008. The reports document changes, activities, and progress of the IVS. The entire contents of this Annual Report also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/ar2008.

International VLBI Service for Geodesy and Astrometry 2011 Annual Report

Science.gov (United States)

Baver, Karen D. (Editor); Behrend, Dirk

2012-01-01

This volume of reports is the 2011 Annual Report of the International VLBI Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the components of IVS. The 2011 Annual Report documents the work of these IVS components over the period January 1, 2011 through December 31, 2011. The reports document changes, activities, and progress of the IVS. The entire contents of this Annual Report also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/ar2011.

International VLBI Service for Geodesy and Astrometry 2005 Annual Report

Science.gov (United States)

Behrend, Dirk (Editor); Baver, Karen D. (Editor)

2006-01-01

This volume of reports is the 2005 Annual Report of the International VLBI Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the components of IVS. The 2005 Annual Report documents the work of these IVS components over the period January 1, 2005 through December 31, 2005. The reports document changes, activities, and progress of the IVS. The entire contents of this Annual Report also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/ar2005.

Identification of the Spawning, Rearing, and Migratory Requirements of Fall Chinook Salmon in the Columbia River Basin, 1991 Annual Progress Report.

Energy Technology Data Exchange (ETDEWEB)

Rondorf, Dennis W.; Miller, William H.

1993-07-01

This document is the 1991 annual progress report for selected studies of fall chinook salmon Oncorhynchus tshawytscha conducted by the US Fish and Wildlife Service. The decline in abundance of fall chinook salmon in the Snake River basin has become a growing concern. In April 1992, Snake River fall chinook salmon were listed as ``threatened`` under the Endangered Species Act. Effective recovery efforts for fall chinook salmon can not be developed until we increase our knowledge of the factors that are limiting the various life history stages. This study attempts to identify those physical and biological factors which influence spawning of fall chinook salmon in the free-flowing Snake River and their rearing and seaward migration through Columbia River basin reservoirs.

1993 Annual progress report for subsidiary agreement No. 2 (1991--1996) between AECL and US/DOE for a radioactive waste management technical co-operative program

Energy Technology Data Exchange (ETDEWEB)

NONE

1993-12-31

A coordinated research program on radioactive waste disposal is being carried out by the Atomic Energy of Canada Limited and the US Department of Energy. This annual report describes progress in the following eight studies: Fundamental materials investigations; In-situ stress determination; Development of a spent fuel dissolution model; Large block tracer test--Experimental testing of retardation models; Laboratory and field tests of in-situ hydrochemical tools; Cigar Lake--Analogue study, actinide and fission product geochemistry; Performance assessment technology exchange; and Development of multiple-well hydraulic test and field tracer test methods.

1993 Annual progress report for subsidiary agreement No. 2 (1991--1996) between AECL and US/DOE for a radioactive waste management technical co-operative program

International Nuclear Information System (INIS)

1993-01-01

A coordinated research program on radioactive waste disposal is being carried out by the Atomic Energy of Canada Limited and the US Department of Energy. This annual report describes progress in the following eight studies: Fundamental materials investigations; In-situ stress determination; Development of a spent fuel dissolution model; Large block tracer test--Experimental testing of retardation models; Laboratory and field tests of in-situ hydrochemical tools; Cigar Lake--Analogue study, actinide and fission product geochemistry; Performance assessment technology exchange; and Development of multiple-well hydraulic test and field tracer test methods

Progress report within the series of GRS-F progress reports on reactor safety, sponsored by the Federal Ministry of Economics and Labour. Period: 1 January - 30 June 2003

International Nuclear Information System (INIS)

2003-01-01

The Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH, by order of the BMWi, continuously issues information on the status of the investigations into the safety of nuclear power plants by publishing semi-annual and annual progress reports within the series of GRS-F-Fortschrittsberichte (GRS-F-Progress Reports). Each progress report represents a compilation of individual reports about the objectives, work performed, results achieved, next steps of the work etc. The individual reports are prepared in a standard form by the research organisations themselves as documentation of their progress in work and are published by the Research Management Division of GRS within the framework of general information on the progress in reactor safety research. The compilation of the reports is classified according to general topics related to reactor safety research. Further, use is made of the classification system ''Joint Safety Research Index'' of the CEC (commission of the european communities). The reports are arranged in sequence of their project numbers. (orig.) [de

Progress report within the series of GRS-F progress reports on reactor safety, sponsored by the Federal Ministry of Economics and Labour. Period: 1 July - 31 December 2003

International Nuclear Information System (INIS)

2004-01-01

The Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH, by order of the BMWi, continuously issues information on the status of the investigations into the safety of nuclear power plants by publishing semi-annual and annual progress reports within the series of GRS-F-Fortschrittsberichte (GRS-F-Progress Reports). Each progress report represents a compilation of individual reports about the objectives, work performed, results achieved, next steps of the work etc. The individual reports are prepared in a standard form by the research organisations themselves as documentation of their progress in work and are published by the Research Management Division of GRS within the framework of general information on the progress in reactor safety research. The compilation of the reports is classified according to general topics related to reactor safety research. Further, use is made of the classification system ''Joint Safety Research Index'' of the CEC (commission of the european communities). The reports are arranged in sequence of their project numbers. (orig.) [de

Canada's climate change voluntary challenge and registry program : 6. annual progress report

International Nuclear Information System (INIS)

2000-10-01

A Canadian integrated energy company, Suncor Energy Inc. comprises a corporate group, three operating business units, and two emerging businesses. This annual Progress Report for Canada's Climate Change Voluntary Challenge and Registry (VCR) Program represents the sixth for this company. Suncor is committed to sustainable development. Some initiatives undertaken in 1999 by Suncor included: Oil Sands Project Millennium, which will more than double the actual production of crude oil and fuel products by 2002. Suncor is divesting of conventional oil properties in order to concentrate on exploration and production of natural gas. Alternative and renewable energy will see an investment of 100 million over the next five years. The money will be allocated to research and development, the production of fuels from biomass, and conversion of municipal solid waste to energy through the recovery of methane from landfills. Since 1990, the emissions of carbon dioxide have been reduced to 14 per cent below 1990 levels, and reductions of 622, 000 tonnes of greenhouse gases. A comprehensive tracking, reporting, and management system for greenhouse gases was implemented. Ongoing improvements in quality and comprehensiveness have validated the methodology used to monitor emissions inventories and sources. Initiatives in internal and external awareness of greenhouse gases education were implemented, such as speaking engagements at climate change activities, the retrofit of schools with advanced energy-efficient technology, education programs, employee suggestion programs, etc. Collaboration with external partners on research and development projects represents a major building block in this approach. Some of the research and development projects involve the development of advanced carbon dioxide capture and geologic sequestration technologies, work on the production of alternative and renewable energy from Canadian municipal landfills, and the study of a new process to extract heavy

Fuel Chemistry Division annual progress report for 1989

International Nuclear Information System (INIS)

Singh Mudher, K.D.

1993-01-01

The progress report gives a brief description of the various activities of the Fuel Chemistry Division of Bhabha Atomic Research Centre, Bombay for the year 1989. The descriptions of activities are arranged under the headings: Fuel Development Chemistry, Chemical Quality Control, Chemistry of Actinides, Sol-Gel process for the non Nuclear Ceramics and Studies related to Nuclear Material Accounting.At the end of the report, a list of papers published in journals and presented at various conferences/symposia is also given. (author). 69 tabs., 6 figs

International VLBI Service for Geodesy and Astrometry 2013 Annual Report

Science.gov (United States)

Baver, Karen D.; Behrend, Dirk; Armstrong, Kyla L.

2014-01-01

This volume of reports is the 2013 Annual Report of the International VLBI Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the permanent components of IVS. The IVS 2013 Annual Report documents the work of the IVS components for the calendar year 2013, our fifteenth year of existence. The reports describe changes, activities, and progress of the IVS. Many thanks to all IVS components who contributed to this Annual Report. With the exception of the first section and the last section, the contents of this Annual Report also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/ar2013.

1999 annual progress report -- Energy conservation team

Energy Technology Data Exchange (ETDEWEB)

Chalk, S. (EERE OTT Office of Advanced Automotive Technologies Energy Conversion Team Leader)

1999-10-19

This report highlights progress achieved during FY 1999 under the Light-duty Fuels Utilization R and D Program. The program is comprised of two elements: the Advanced Petroleum-Based APB Fuels Program which focused on developing and testing advanced fuels for use with compression-ignition direct-injection (CIDI) engines and fuel cells and the Alternative Fuels Program which focused on Natural gas and natural gas derived fuels. The report contains 17 summaries of industry and National Laboratory projects. Fuel efficient vehicles with very low emissions are essential to meet the challenges of climate change, energy security, and improved air quality. The authors anticipate cooperative efforts with the auto and energy industries to develop new and innovative technologies that will be used to make advanced transportation vehicles that are fuel efficient, clean, and safe.

Integral Fast Reactor Program annual progress report, FY 1994

International Nuclear Information System (INIS)

Chang, Y.I.; Walters, L.C.; Laidler, J.J.; Pedersen, D.R.; Wade, D.C.; Lineberry, J.J.

1994-12-01

This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1994. Technical accomplishments are presented in the following areas of the IFR technology development activities: metal fuel performance; pyroprocess development; safety experiments and analyses; core design development; fuel cycle demonstration; and LMR technology R ampersand D

NSLS annual report 1984

Energy Technology Data Exchange (ETDEWEB)

Klaffky, R.; Thomlinson, W. (eds.)

1984-01-01

The first comprehensive Annual Report of the National Synchrotron Light Source comes at a time of great activity and forward motion for the facility. In the following pages we outline the management changes that have taken place in the past year, the progress that has been made in the commissioning of the x-ray ring and in the enhanced utilization of the uv ring, together with an extensive discussion of the interesting scientific experiments that have been carried out.

NSLS annual report 1984

International Nuclear Information System (INIS)

Klaffky, R.; Thomlinson, W.

1984-01-01

The first comprehensive Annual Report of the National Synchrotron Light Source comes at a time of great activity and forward motion for the facility. In the following pages we outline the management changes that have taken place in the past year, the progress that has been made in the commissioning of the x-ray ring and in the enhanced utilization of the uv ring, together with an extensive discussion of the interesting scientific experiments that have been carried out

The theory of hadronic systems. Annual progress report

International Nuclear Information System (INIS)

Gibbs, W.R.

1993-01-01

This report briefly discusses progress on the following topics: isospin breaking in the pion-nucleon system; direct capture of pions into deeply bound atomic states; knock out of secondary components in the nucleus; study of the radii of neutron distributions in nuclei; the hadronic double scattering operator; transparency in pion production; asymmetry in pion scattering and charge exchange from polarized nuclei; the mechanism of pion absorption in nuclei; the neutron-proton charge-exchange reaction; modification of the fundamental structure of nucleons in nuclei; and antiproton annihilation in nuclei

Wills Plasma Physics Department annual progress report 1982

International Nuclear Information System (INIS)

1982-01-01

Progress in the experimental program using the research tokamak TORTUS is presented. The main thrust of the program is the study of the characteristics of hydromagnetic waves in tokamak plasmas and in the use of such waves in r.f. heating. Work on runaway electron production, on wave propagation in collisional plasmas and on hydromagnetic shock wave studies is reported. Diagnostic techniques and equipment described include a laser interferometer system and techniques based on the observation of resonance fluorescence and near-resonant scattering of a laser beam from atomic species in a plasma

International VLBI Service for Geodesy and Astrometry: 1999 Annual Report

Science.gov (United States)

Vandenberg, Nancy R. (Editor)

1999-01-01

This volume of reports is the 1999 Annual Report of the International VLBI Service for Geodesy and Astrometry -IVS. The individual reports were contributed by VLBI groups in the international geodetic community who constitute the components of IVS. The 1999 Annual Report documents the work of the IVS components for the year ending March 1, 1999, the official inauguration date of IVS. As the newest of the space technique services, IVS decided to publish this Annual Report as a reference to our organization and its components. The entire contents of this Annual Report also appear on the IVS website at: http://ivscc.gsfc.nasa.gov/pub/arl999. The IVS 1999 Annual Report will be a valuable reference for information about IVS and its components. This Annual Report will serve as a baseline from which we can measure the anticipated progress of IVS in coming years.

Integral Fast Reactor Program. Annual progress report, FY 1992

Energy Technology Data Exchange (ETDEWEB)

Chang, Y.I.; Walters, L.C.; Laidler, J.J.; Pedersen, D.R.; Wade, D.C.; Lineberry, M.J.

1993-06-01

This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1992. Technical accomplishments are presented in the following areas of the IFR technology development activities: (1) metal fuel performance, (2) pyroprocess development, (3) safety experiments and analyses, (4) core design development, (5) fuel cycle demonstration, and (6) LMR technology R&D.

Annual technical progress report: reactor safety, Government fiscal year 1978

International Nuclear Information System (INIS)

1978-01-01

Progress in LMFBR safety studies on accident debris behavior is reported under the following subtask titles: high-temperature-concentration aerosols, large-scale molten fuel tests, sodium release tests, and risk analysis

Community's research and development programme on radioactive waste management and storage shared-cost action (1990-94). Annual progress report 1991

International Nuclear Information System (INIS)

1992-01-01

In december 1989 the Council of Ministers of the European Communities adopted the fourth R and D programme on 'Management and Storage of radioactive waste' for the period 1990-1994. Contract negotiations for selected research proposals lead to the signature of contracts with some 93 bodies in charge of carrying out the working programme. This annual report, covering the year 1991 presents for each contract the objectives, the whole research programme and a synopsis of progress and results achieved as prepared by the contractor under the responsibility of the project leader. Part A deals with the study of management systems, treatment and characterization of waste, general aspects of the waste disposal and the safety of geological disposal systems. The running activities on construction and operation of underground facilities in candidated geological media for disposal is presented in part B

Radiochemistry Division annual progress report for 1982

International Nuclear Information System (INIS)

Bhargava, V.K.; Rao, V.K.

1984-01-01

The progress report of the Radiochemistry Division of the Bhabha Atomic Research Centre, Bombay, presents the research and development work carried out during 1982 in the form of individual summaries arranged under the headings: reactor fuel chemistry, heavy element chemistry, radioanalytical chemistry, and nuclear chemistry. Some of the highlights of the R and D activities are: (1) optimisation of the chemical parameters for the preparation of UO 2 microspheres by internal gelation method, (2) synergetic extraction studies of various actinides from aqueous solutions, (3) development of methods of determination of uranium, 241 Am and 239 Pu, (4) fission studies of 232 Th, 236 U, 252 Cf and 229 Th, (5) determination of half-life of 241 Pu by various methods. A list of publications of the members of the Division published during 1982 is also given. (M.G.B.)

Research Progress in Oncology. Highlighting and Exploiting the Roles of Several Strategic Proteins in Understanding Cancer Biology

Directory of Open Access Journals (Sweden)

Odiba Arome S.

2016-01-01

Full Text Available Although almost all biological processes are mediated by a variety of proteins, it is important to bring to spotlight recent experimental and clinical research advances that had their focus on highlighting and taking advantage of the roles of several strategic proteins in order to gain more understanding of cancer biology. Proteins have a major stake in the initiation, progression, sustenance and completion of cellular processes, and have also demonstrated their vital roles in cancer processes. The characteristic functions of proteins and modified proteins have been utilized in the understanding and treatment of cancer. Recent insights in such roles and applications include linker histone H1.2 in the compaction of chromatin and gene silencing via the recognition of H3K27me3; c-Jun with Fra-2/c-Fos in the promotion of aggressive tumour phenotypes in tongue cancer; the use of sodium channelinhibiting agents targeting the transmembrane protein in breast, colon and prostate cancer; SET-mediated activities; protein interaction networks in glioma; Gpnmb significance as a biomarker; β-carbolines inhibition on Wnt/β-catenin signaling; p53 mutants co-opt chromatin pathways; Bone morphogenetic protein 4 as regulator of the behaviors of cancer cell; Brain-Expressed X-linked (BEX proteins in human cancers; targeting CDK4/6 including protein kinases to make a reversal of multidrug resistance in sarcoma. In-depth knowledge of Proteomics will go a long way in helping us uncover a lot more strategies that will help us in the long fight against cancer.

EDF group - annual report 2003

International Nuclear Information System (INIS)

2004-01-01

This document contains the magazine, the financial statements and the sustainable development report of Electricite de France (EdF) group for 2003: 1 - the magazine (chairman's statement, group profile, vision and strategy); 2 - the consolidated financial statements for the period ended 31 December 2003 (statutory auditors' report on the consolidated financial statements, EDF's summary annual financial statements); 3 - sustainable development report (transparency and dialogue, responsibility, commitment, partnerships for progress). (J.S.)

Annual report 1998-1999

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-07-01

This is the Annual Report of the Atomic Energy of Canada Limited for the year ending March 31, 1999 and summarizes the activities of AECL during the period 1998-1999. The Activities covered in this Report include the CANDU Reactor Business, with excellent progress reported on the construction of two 700 MWe-class CANDU reactors in Qinshan, China. In the Republic of Korea, Wolsong Unit entered into commercial operation and Wolsong Unit 4 achieved sustained nuclear reaction. The Report also covers AECL's R and D and Waste Management programs. In the R and D section, the report outlines the development of the CANFLEX fuel bundle, Fuel Channels, Reactor Safety, Code Validation, Fuels and Fuel Cycles as well as Heavy Water production. Progress in the Waste Management program is also discussed.

Annual report 1998-1999

International Nuclear Information System (INIS)

1999-01-01

This is the Annual Report of the Atomic Energy of Canada Limited for the year ending March 31, 1999 and summarizes the activities of AECL during the period 1998-1999. The Activities covered in this Report include the CANDU Reactor Business, with excellent progress reported on the construction of two 700 MWe-class CANDU reactors in Qinshan, China. In the Republic of Korea, Wolsong Unit entered into commercial operation and Wolsong Unit 4 achieved sustained nuclear reaction. The Report also covers AECL's R and D and Waste Management programs. In the R and D section, the report outlines the development of the CANFLEX fuel bundle, Fuel Channels, Reactor Safety, Code Validation, Fuels and Fuel Cycles as well as Heavy Water production. Progress in the Waste Management program is also discussed

Integral Fast Reactor Program annual progress report, FY 1991

International Nuclear Information System (INIS)

1992-06-01

This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1991. Technical accomplishments are presented in the following areas of the IFR technology development activities: (1) metal fuel performance, (2) pyroprocess development, (3) safety experiments and analyses, (4) core design development, (5) fuel cycle demonstration, and (6) LMR technology R ampersand D

FY2015 Lightweight Materials R&D Annual Progress Report

Energy Technology Data Exchange (ETDEWEB)

None, None

2016-09-30

The Lightweight Materials research and development (R&D) area within the DOE Vehicle Technologies Office (VTO) provides support and guidance for many cutting-edge automotive technologies under development. Research focuses on addressing critical barriers to commercializing lightweight materials for passenger and commercial vehicles. This report describes the progress made on the research and development projects funded by the Lightweight Materials area.

Integral Fast Reactor Program. Annual progress report, FY 1993

Energy Technology Data Exchange (ETDEWEB)

Chang, Y.I.; Walters, L.C.; Laidler, J.J.; Pedersen, D.R.; Wade, D.C.; Lineberry, M.J.

1994-10-01

This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1993. Technical accomplishments are presented in the following areas of the IFR technology development activities: (1) metal fuel performance, (2) pyroprocess development, (3) safety experiments and analyses, (4) core design development, (5) fuel cycle demonstration, and (6) LMR technology R and D.

Integral Fast Reactor Program. Annual progress report, FY 1993

International Nuclear Information System (INIS)

Chang, Y.I.; Walters, L.C.; Laidler, J.J.; Pedersen, D.R.; Wade, D.C.; Lineberry, M.J.

1994-10-01

This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1993. Technical accomplishments are presented in the following areas of the IFR technology development activities: (1) metal fuel performance, (2) pyroprocess development, (3) safety experiments and analyses, (4) core design development, (5) fuel cycle demonstration, and (6) LMR technology R and D

Effects of caffeine on protein phosphorylation and cell cycle progression in X-irradiated two-cell mouse embryos

International Nuclear Information System (INIS)

Jung, Th.; Streffer, C.

1992-01-01

To understand the mechanism of the caffeine-induced uncoupling of mitosis and the cellular reactions to DNA-damaging agents, the authors studied the effects of caffeine treatment on cell cycle progression and protein phosphorylation in two-cell mouse embryos after X-irradiation. Caffeine alone had no effect on timing of and changes in phosphorylation associated with the embryonic cell cycle. In combination with X-rays, caffeine was able to override the radiation induced G 2 block and restored normal timing of these phosphorylation changes after X-irradiation. New additional changes in protein phosphorylation appeared after the combined treatment. Isobutyl-methylxanthine (IBMX), a substance chemically related to caffeine but a more specific inhibitor of the phosphodiesterase that breaks down cyclic AMP, reduced radiation induced G 2 block from 4 to 5 h to about 1 h and restored the cell cycle associated changes in protein phosphorylation. (author)

Effects of caffeine on protein phosphorylation and cell cycle progression in X-irradiated two-cell mouse embryos

Energy Technology Data Exchange (ETDEWEB)

Jung, Th. (AFRC Institute of Animal Physiology and Genetics Research, Babraham (United Kingdom)); Streffer, C. (Essen Univ (Germany). Inst. fuer Medizinische Strahlenbiolgie)

1992-08-01

To understand the mechanism of the caffeine-induced uncoupling of mitosis and the cellular reactions to DNA-damaging agents, the authors studied the effects of caffeine treatment on cell cycle progression and protein phosphorylation in two-cell mouse embryos after X-irradiation. Caffeine alone had no effect on timing of and changes in phosphorylation associated with the embryonic cell cycle. In combination with X-rays, caffeine was able to override the radiation induced G[sub 2] block and restored normal timing of these phosphorylation changes after X-irradiation. New additional changes in protein phosphorylation appeared after the combined treatment. Isobutyl-methylxanthine (IBMX), a substance chemically related to caffeine but a more specific inhibitor of the phosphodiesterase that breaks down cyclic AMP, reduced radiation induced G[sub 2] block from 4 to 5 h to about 1 h and restored the cell cycle associated changes in protein phosphorylation. (author).

The Community's research and development programme on radioactive waste management and storage shared cost action annual progress report 1989 volume 2

International Nuclear Information System (INIS)

1990-01-01

In 1985 the Council of Ministers of the European Communities adopted a five-year R and D programme on 'Management and storage of radioactive waste' for the period 1985-89. The R and D programme was carried out by public organizations and private firms in the Member States. By the end of 1989 over 256 contracts had been concluded with some 70 bodies. This annual report, covering the year 1989, is the fourth of its type. For each contract it gives the objectives, working programme and a summary of progress and results obtained as prepared by the contractor under the responsibility of the project leader. The report contains sections on treatment and conditioning of radioactive waste, characterization of conditioned radioactive waste, general aspects of radioactive waste disposal, and the performance of isolation systems

The Community's research and development programme on radioactive waste management and storage shared cost action annual progress report 1989 volume 1

International Nuclear Information System (INIS)

1990-01-01

In 1985 the Council of Ministers of the European Communities adopted a five-year R and D programme on 'Management and storage of radioactive waste' for the period 1985-89. The R and D programme was carried out by public organizations and private firms in the Member States. By the end of 1989 over 256 contracts had been concluded with some 70 bodies. This annual report, covering the year 1989, is the fourth of its type. For each contract it gives the objectives, working programme and a summary of progress and results obtained as prepared by the contractor under the responsibility of the project leader. The report contains sections on treatment and conditioning of radioactive waste, characterization of conditioned radioactive waste, general aspects of radioactive waste disposal, and the performance of isolation systems

Semi-annual progress report for the period ending December 31, 1958

Energy Technology Data Exchange (ETDEWEB)

None

1958-01-01

Studies were continued on radiation-induced reactions of nitrophenols and ferriprotoporphyrins. No changes in serum glycoproteins or seromucoids were detected in embryo chickens and young chicks as a result of irradiation. Progress is reported in studies on: the radiosensitivity of bacteriophages; the influence of x irradiation on thiamine transport in rat intestine; the histologic changes in bone, marrow, blood, and other body tissues due to localized ..beta.. irradiation; the effects of irradiation on nervous responses in cats; studies of fatty acid metabolism in rats; electrophoretic studies of abnormal plasma proteins; the specificity of thyroxin inhibition of acyl phosphatase; the pharmacological properties of Mellaril; the local toxicity of organic moderators for intact and abraded skin; the effects of oral quinoxaline on radiation mortality in mice; the development of leukemia and other neoplasms in mice receiving cell-free tissue extracts from a high-leukemia strain; the development of liver function tests using iodine-131-Rose Bengal; development of techniques and equipment of renograms using iodine-131 Miokon; the development of sensitive tests for the diagnosis of liver and kidney diseases; tracer studies of bone metabolism; the development of radiation detection instruments and chemical dosimeters; an underwater spark pulser, an improved illuminating system for the electron microscope; and techniques for electron microscopic studies of tissues and the spectrographic analysis of plant ash; studies on the fate and persistence of strontium-90 and cesium-137 in various locations and biological materials collected in the vicinity of the Nevada Test Site; and aerial surveying for evaluation of fall-out patterns.

Chemical and biological nonproliferation program. FY99 annual report

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-03-01

This document is the first of what will become an annual report documenting the progress made by the Chemical and Biological Nonproliferation Program (CBNP). It is intended to be a summary of the program's activities that will be of interest to both policy and technical audiences. This report and the annual CBNP Summer Review Meeting are important vehicles for communication with the broader chemical and biological defense and nonproliferation communities. The Chemical and Biological Nonproliferation Program Strategic Plan is also available and provides additional detail on the program's context and goals. The body of the report consists of an overview of the program's philosophy, goals and recent progress in the major program areas. In addition, an appendix is provided with more detailed project summaries that will be of interest to the technical community.

Annual report and accounts 1991/92

International Nuclear Information System (INIS)

1992-01-01

This annual report of Scottish Power highlights profit before tax; earnings per share; dividends; net debt reduction; the significant progress achieved in Company restructuring; and the fact that domestic customers now have the lowest tarrifs in the United Kingdom. A summary of the Company's results is given, and competitive opportunities, exports, transmission and distribution, and environmental issues are discussed. (author)

Ionization in liquids [annual] progress report, 1993--1994

International Nuclear Information System (INIS)

Bakale, G.

1994-01-01

Progress in 1993--94 was focused on delineating how ions of the model nonpolar spherical solute Buckminsterfullerene interact differently with various nonpolar solvents than does the ellipsoidal fullerene analog C-70, and exposing a variety of new audiences to the electrophilicity-carcinogenicity relationship in order to obtain fresh insight into this relationship that may lead to elucidation of the role of electrons in carcinogenesis and thereby a better understanding of the biological effects of ionizing radiation. To achieve these goals a new collaboration was established with scientists at Oak Ridge National Lab who have unique facilities to characterize fullerene and its radiolytic products

International VLBI Service for Geodesy and Astrometry 2012 Annual Report

Science.gov (United States)

Baver, Karen D.; Behrend, Dirk; Armstrong, Kyla L.

2013-01-01

This volume of reports is the 2012 Annual Report of the International VLBI Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the permanent components of IVS. The IVS 2012 Annual Report documents the work of the IVS components for the calendar year 2012, our fourteenth year of existence. The reports describe changes, activities, and progress ofthe IVS. Many thanks to all IVS components who contributed to this Annual Report. With the exception of the first section and parts of the last section (described below), the contents of this Annual Report also appear on the IVS Web site athttp:ivscc.gsfc.nasa.gov/publications/ar2012

Validating predictors of disease progression in a large cohort of primary-progressive multiple sclerosis based on a systematic literature review.

Directory of Open Access Journals (Sweden)

Jan-Patrick Stellmann

Full Text Available New agents with neuroprotective or neuroregenerative potential might be explored in primary-progressive Multiple Sclerosis (PPMS--the MS disease course with leading neurodegenerative pathology. Identification of patients with a high short-term risk for progression may minimize study duration and sample size. Cohort studies reported several variables as predictors of EDSS disability progression but findings were partially contradictory.To analyse the impact of published predictors on EDSS disease progression in a large cohort of PPMS patients.A systematic literature research was performed to identify predictors for disease progression in PPMS. Individual case data from the Sylvia Lawry Centre (SLC and the Hamburg MS patient database (HAPIMS was pooled for a retrospective validation of these predictors on the annualized EDSS change.The systematic literature analysis revealed heterogeneous data from 3 prospective and 5 retrospective natural history cohort studies. Age at onset, gender, type of first symptoms and early EDSS changes were available for validation. Our pooled cohort of 597 PPMS patients (54% female had a mean follow-up of 4.4 years and mean change of EDSS of 0.35 per year based on 2503 EDSS assessments. There was no significant association between the investigated variables and the EDSS-change.None of the analysed variables were predictive for the disease progression measured by the annualized EDSS change. Whether PPMS is still unpredictable or our results may be due to limitations of cohort assessments or selection of predictors cannot be answered. Large systematic prospective studies with new endpoints are needed.

A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression.

Science.gov (United States)

Mir, Riyaz A; Bele, Aditya; Mirza, Sameer; Srivastava, Shashank; Olou, Appolinaire A; Ammons, Shalis A; Kim, Jun Hyun; Gurumurthy, Channabasavaiah B; Qiu, Fang; Band, Hamid; Band, Vimla

2015-12-28

Ecdysoneless (ECD) is an evolutionarily conserved protein whose germ line deletion is embryonic lethal. Deletion of Ecd in cells causes cell cycle arrest, which is rescued by exogenous ECD, demonstrating a requirement of ECD for normal mammalian cell cycle progression. However, the exact mechanism by which ECD regulates cell cycle is unknown. Here, we demonstrate that ECD protein levels and subcellular localization are invariant during cell cycle progression, suggesting a potential role of posttranslational modifications or protein-protein interactions. Since phosphorylated ECD was recently shown to interact with the PIH1D1 adaptor component of the R2TP cochaperone complex, we examined the requirement of ECD phosphorylation in cell cycle progression. Notably, phosphorylation-deficient ECD mutants that failed to bind to PIH1D1 in vitro fully retained the ability to interact with the R2TP complex and yet exhibited a reduced ability to rescue Ecd-deficient cells from cell cycle arrest. Biochemical analyses demonstrated an additional phosphorylation-independent interaction of ECD with the RUVBL1 component of the R2TP complex, and this interaction is essential for ECD's cell cycle progression function. These studies demonstrate that interaction of ECD with RUVBL1, and its CK2-mediated phosphorylation, independent of its interaction with PIH1D1, are important for its cell cycle regulatory function. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Environmental Sciences Division annual progress report for period ending September 30, 1983

Energy Technology Data Exchange (ETDEWEB)

1984-04-01

This annual report summarizes activities in the Aquatic Ecology, Earth Sciences, Environmental Analyses, and Terrestrial Ecology sections, as well as in the Fossil Energy, Biomass, Low-Level Waste Research and Management, and Global Carbon Cycle Programs. Separate abstracts have been prepared for each section. (ACR)

Environmental Sciences Division annual progress report for period ending September 30, 1983

International Nuclear Information System (INIS)

1984-04-01

This annual report summarizes activities in the Aquatic Ecology, Earth Sciences, Environmental Analyses, and Terrestrial Ecology sections, as well as in the Fossil Energy, Biomass, Low-Level Waste Research and Management, and Global Carbon Cycle Programs. Separate abstracts have been prepared for each section

Annual report 2000. Department of wastes disposal and storage

International Nuclear Information System (INIS)

2001-01-01

This annual report presents the missions, the organization, the researches progress, the events, the publications and the personnel formation of the Department of wastes disposal and storage in the year 2000, one of the CEA fuel cycle Direction. (A.L.B.)

Development of protein biomarkers in cerebrospinal fluid for secondary progressive multiple sclerosis using selected reaction monitoring mass spectrometry (SRM-MS

Directory of Open Access Journals (Sweden)

Jia Yan

2012-07-01

Full Text Available Abstract Background Multiple sclerosis (MS is a chronic inflammatory disorder of the central nervous system (CNS. It involves damage to the myelin sheath surrounding axons and to the axons themselves. MS most often presents with a series of relapses and remissions but then evolves over a variable period of time into a slowly progressive form of neurological dysfunction termed secondary progressive MS (SPMS. The reasons for this change in clinical presentation are unclear. The absence of a diagnostic marker means that there is a lag time of several years before the diagnosis of SPMS can be established. At the same time, understanding the mechanisms that underlie SPMS is critical to the development of rational therapies for this untreatable stage of the disease. Results Using high performance liquid chromatography-coupled mass spectrometry (HPLC; we have established a highly specific and sensitive selected reaction monitoring (SRM assay. Our multiplexed SRM assay has facilitated the simultaneous detection of surrogate peptides originating from 26 proteins present in cerebrospinal fluid (CSF. Protein levels in CSF were generally ~200-fold lower than that in human sera. A limit of detection (LOD was determined to be as low as one femtomol. We processed and analysed CSF samples from a total of 22 patients with SPMS, 7 patients with SPMS treated with lamotrigine, 12 patients with non-inflammatory neurological disorders (NIND and 10 healthy controls (HC for the levels of these 26 selected potential protein biomarkers. Our SRM data found one protein showing significant difference between SPMS and HC, three proteins differing between SPMS and NIND, two proteins between NIND and HC, and 11 protein biomarkers showing significant difference between a lamotrigine-treated and untreated SPMS group. Principal component analysis (PCA revealed that these 26 proteins were correlated, and could be represented by four principal components. Overall, we established an

Neutron scattering. Annual progress report 1997

International Nuclear Information System (INIS)

Allenspach, P.; Boeni, B.; Fischer, P.; Furrer, A.

1998-02-01

The present progress report describes the scientific and technical activities obtained by LNS staff members in 1997. It also includes the work performed by external groups at our CRG instruments D1A and IN3 at the ILL Grenoble. Due to the outstanding properties of neutrons and x-rays the research work covered many areas of science and materials research. The highlight of the year 1997 was certainly the production of neutrons at the new spallation neutron source SINQ. From July to November, SINQ was operating for typically two days/week and allowed the commissioning of four instruments at the neutron guide system: - the triple-axis spectrometer Druechal, - the powder diffractometer DMC, - the double-axis diffractometer TOPSI, the polarised triple-axis spectrometer TASP. These instruments are now fully operational and have already been used for condensed matter studies, partly in cooperation with external groups. Five further instruments are in an advanced state, and their commissioning is expected to occur between June and October 1998: - the high-resolution powder diffractometer HRPT, - the single-crystal diffractometer TriCS, - the time-of-flight spectrometer FOCUS, - the reflectometer AMOR, - the neutron optical bench NOB. Together with the small angle neutron scattering facility SANS operated by the spallation source department, all these instruments will be made available to external user groups in the future. (author) figs., tabs., refs

Memphis State University Center for Nuclear Studies progress report

International Nuclear Information System (INIS)

1975-11-01

Progress made on the development of specialized education programs for the nuclear industry through the month of October, 1975, is outlined. The survey of the nuclear industry includes manpower resources and requirements of nuclear industry, annual training requirements of nuclear plants, and the educational curriculum for nuclear plant operational staff. Also discussed are the general organization of the project, student enrollment and progress and industrial participation

Nuclear structure from radioactive decay. Annual progress report

International Nuclear Information System (INIS)

Wood, J.L.

1982-01-01

The most exciting development during this year has been the formulation of a unified description of shape coexistence in nuclei. The picture is built on the idea that deformation in nuclei is due to an attractive proton-neutron force acting in the valence shell model space. The excitation of nucleon pairs across closed shells effectively increases the number of valence nucleons, giving rise to a set of coexisting states with larger deformation. The major area of activity is the study of neutron-deficient nuclei around the Z = 82 shell closure, with special emphasis on the levels of the odd-mass Pt, Au, Hg and Tl isotopes. Progress is reported

Annual Report 2011

International Nuclear Information System (INIS)

2011-01-01

The PNRI Annual Report summarizes the institute's yearly progress in nuclear research and development projects, services, regulations, technology transfers and information dissemination on the peaceful applications of nuclear science and technology. The establishment and future operation of the Technetium 99m Generator Facility and the Electron Beam Facility will enhance the institute's capabilities. The PNRI has made great strides in agricultural and environmental research, helping to improve crop growth and water resource management. It served more clients availing of irradiation and other services, and was vigilant in monitoring incidents in the Southeast Asian region to preserve national nuclear safety and security

FY2013 Vehicle and Systems Simulation and Testing R&D Annual Progress Report

Energy Technology Data Exchange (ETDEWEB)

none,

2014-02-01

FY 2013 annual report focuses on the following areas: vehicle modeling and simulation, component and systems evaluations, laboratory and field evaluations, codes and standards, industry projects, and vehicle systems optimization.

1975 annual report of the Elementary Particle Physics Department

International Nuclear Information System (INIS)

1976-03-01

The annual report gives a short summary of experiments in progress and of approved proposals of experiments to be performed at CERN by the Elementary Particle Physics Department of Saclay, and also publication lists and informations about the Department activities during 1975 [fr

Enabling Success: 2011-2012 Think Tank Initiative Annual Report ...

International Development Research Centre (IDRC) Digital Library (Canada)

2013-06-12

In addition to a review of the Initiative's overall progress, this year's annual report, Enabling Success, captures the conversations at last year's TTI Exchange in Cape Town about what it means to be a ... English · Français ... June 12, 2013.

Annual Progress Report, 1975. Southern Rural Development Center, Mississippi State University. SRDC Series Publication No. 10.

Science.gov (United States)

Southern Rural Development Center, State College, MS.

Included in this second annual report on the Southern Rural Development Center's (SRDC) 1974-75 plan of work are data re: orientation visits; regional workshops; technical consultants; liaison with regional agencies and organizations; information dissemination; annual evaluation; functional networks in the areas of land use issues, citizen…

EFFECT OF 3-YEARS ADHERENCE TO A LOW PROTEIN DIET ON THE PROGRESSION OF GLOMERULAR FILTRATION RATE IN CHRONIC KIDNEY DISEASE PATIENTS

Directory of Open Access Journals (Sweden)

Felipe Rizzetto

2012-06-01

There was no difference between diabetic and non-diabetic patients who adhered to the diet. Both groups showed improvement on GFR. In conclusion, these analyses suggest that a lower protein intake retards the progression of renal disease.

Building America Systems Integration Research Annual Report: FY 2012

Energy Technology Data Exchange (ETDEWEB)

Gestwick, M.

2013-05-01

This document is the Building America FY2012 Annual Report, which includes an overview of the Building America Program activities and the work completed by the National Renewable Energy Laboratory and the Building America industry consortia (the Building America teams). The annual report summarizes major technical accomplishments and progress towards U.S. Department of Energy Building Technologies Program's multi-year goal of developing the systems innovations that enable risk-free, cost effective, reliable and durable efficiency solutions that reduce energy use by 30%-50% in both new and existing homes.

Building America Systems Integration Research Annual Report. FY 2012

Energy Technology Data Exchange (ETDEWEB)

Gestwick, Michael [National Renewable Energy Lab. (NREL), Golden, CO (United States)

2013-05-01

This Building America FY2012 Annual Report includes an overview of the Building America Program activities and the work completed by the National Renewable Energy Laboratory and the Building America industry consortia (the Building America teams). The annual report summarizes major technical accomplishments and progress towards U.S. Department of Energy Building Technologies Program's multi-year goal of developing the systems innovations that enable risk-free, cost effective, reliable and durable efficiency solutions that reduce energy use by 30%-50% in both new and existing homes.

Nuclear-chemistry research and spectroscopy with radioactive sources. Eighteenth annual progress report

International Nuclear Information System (INIS)

Fink, R.W.

1982-01-01

Progress is reported on nuclear spectroscopy studies including lifetimes of the g/sub 7/2/ shell-model intruder states in 107 109 Ag, lifetime of the new /sup 187m/Au isomer, the decay of 187 Au - 187 Pt, decay of /sup 201m,g/Po, 203 At, and 125 Ba, and L-shell orbital EC probability and decay energy in 207 Bi decay. Also progress on nuclear model calculations of nuclear structure is reported

Toward Small-Molecule Inhibition of Protein-Protein Interactions: General Aspects and Recent Progress in Targeting Costimulatory and Coinhibitory (Immune Checkpoint) Interactions.

Science.gov (United States)

Bojadzic, Damir; Buchwald, Peter

2018-05-30

Protein-protein interactions (PPIs) that are part of the costimulatory and coinhibitory (immune checkpoint) signaling are critical for adequate T cell response and are important therapeutic targets for immunomodulation. Biologics targeting them have already achieved considerable clinical success in the treatment of autoimmune diseases or transplant recipients (e.g., abatacept, belatacept, and belimumab) as well as cancer (e.g., ipilimumab, nivolumab, pembrolizumab, atezolizumab, durvalumab, and avelumab). In view of such progress, there have been only relatively limited efforts toward developing small-molecule PPI inhibitors (SMPPIIs) targeting these cosignaling interactions, possibly because they, as all other PPIs, are difficult to target by small molecules and were not considered druggable. Nevertheless, substantial progress has been achieved during the last decade. SMPPIIs proving the feasibility of such approaches have been identified through various strategies for a number of cosignaling interactions including CD40-CD40L, OX40-OX40L, BAFFR-BAFF, CD80-CD28, and PD-1-PD-L1s. Here, after an overview of the general aspects and challenges of SMPPII-focused drug discovery, we review them briefly together with relevant structural, immune-signaling, physicochemical, and medicinal chemistry aspects. While so far only a few of these SMPPIIs have shown activity in animal models (DRI-C21045 for CD40-D40L, KR33426 for BAFFR-BAFF) or reached clinical development (RhuDex for CD80-CD28, CA-170 for PD-1-PD-L1), there is proof-of-principle evidence for the feasibility of such approaches in immunomodulation. They can result in products that are easier to develop/manufacture and are less likely to be immunogenic or encounter postmarket safety events than corresponding biologics, and, contrary to them, can even become orally bioavailable. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Yucca Mountain Project - Argonne National Laboratory annual progress report, FY 1994

Energy Technology Data Exchange (ETDEWEB)

Bates, J.K.; Fortner, J.A.; Finn, P.A.; Wronkiewicz, D.J.; Hoh, J.C.; Emery, J.W.; Buck, E.C.; Wolf, S.F.

1995-02-01

This document reports on the work done by the Nuclear Waste Management Section of the Chemical Technology Division (CMT), Argonne National Laboratory, in the period October 1993-September 1994. Studies have been performed to evaluate the performance of nuclear waste glass and spent fuel samples under unsaturated conditions (low volume water contact) that are likely to exist in the Yucca Mountain environment being considered as a potential site for a high-level waste repository. Tests with simulated waste glasses have been in progress for over eight years and demonstrate that actinides from initially fresh glass surfaces will be released as a result of the spallation of reacted glass layers from the surface, as the small volume of water passes over the waste form. Studies are also underway to evaluate the performance of spent fuel samples and unirradiated UO{sub 2} in projected repository conditions. Tests with UO{sub 2} have been ongoing for nine years and show that the oxidation of UO{sub 2} occurs rapidly, and the resulting paragenetic sequence of secondary phases that form on the sample surface is similar to that observed in natural analogues. The reaction of spent fuel samples under conditions similar to those used with UO{sub 2} have been in progress for nearly two years, and the results suggest that spent fuel follows the same reaction progress as UO{sub 2}. The release of individual fission products and transuranic elements was not congruent, with the release being controlled by the formation of small particles or colloids that are suspended in solution and transported away from the waste form. The reaction progress depends on the composition of the spent fuel samples used and, likely, on the composition of the groundwater that contacts the waste form.

The Chip-Scale Atomic Clock - Recent Development Progress

Science.gov (United States)

2004-09-01

35th Annual Precise Time and Time Interval (PTTI) Meeting 467 THE CHIP-SCALE ATOMIC CLOCK – RECENT DEVELOPMENT PROGRESS R. Lutwak ...1] R. Lutwak , et al., 2003, “The Chip-Scale Atomic Clock – Coherent Population Trapping vs. Conventional Interrogation,” in

Mild trifunctional protein deficiency is associated with progressive neuropathy and myopathy and suggests a novel genotype-phenotype correlation.

OpenAIRE

Ibdah, J A; Tein, I; Dionisi-Vici, C; Bennett, M J; IJlst, L; Gibson, B; Wanders, R J; Strauss, A W

1998-01-01

Human mitochondrial trifunctional protein (TFP) is a heterooctamer of four alpha- and four beta-subunits that catalyzes three steps in the beta-oxidation spiral of long-chain fatty acids. TFP deficiency causes a Reye-like syndrome, cardiomyopathy, or sudden, unexpected death. We delineated the molecular basis for TFP deficiency in two patients with a unique phenotype characterized by chronic progressive polyneuropathy and myopathy without hepatic or cardiac involvement. Single-stranded confor...

Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in transgenic mice causes progressive renal damage and hyperuricemia.

Directory of Open Access Journals (Sweden)

Lijie Ma

Full Text Available Hereditary mutations in Tamm-Horsfall protein (THP/uromodulin gene cause autosomal dominant kidney diseases characterized by juvenile-onset hyperuricemia, gout and progressive kidney failure, although the disease pathogenesis remains unclear. Here we show that targeted expression in transgenic mice of a mutation within the domain of 8 cysteines of THP in kidneys' thick ascending limb (TAL caused unfolded protein response in younger (1-month old mice and apoptosis in older (12-month old mice. While the young mice had urine concentration defects and polyuria, such defects progressively reversed in the older mice to marked oliguria, highly concentrated urine, fibrotic kidneys and reduced creatinine clearance. Both the young and the old transgenic mice had significantly higher serum uric acid and its catabolic product, allantoin, than age-matched wild-type mice. This THP mutation apparently caused primary defects in TAL by compromising the luminal translocation and reabsorptive functions of NKCC2 and ROMK and secondary responses in proximal tubules by upregulating NHE3 and URAT1. Our results strongly suggest that the progressive worsening of kidney functions reflects the accumulation of the deleterious effects of the misfolded mutant THP and the compensatory responses. Transgenic mice recapitulating human THP/uromodulin-associated kidney diseases could be used to elucidate their pathogenesis and test novel therapeutic strategies.

Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in transgenic mice causes progressive renal damage and hyperuricemia

Science.gov (United States)

Landry, Nichole K.; El-Achkar, Tarek M.; Lieske, John C.

2017-01-01

Hereditary mutations in Tamm-Horsfall protein (THP/uromodulin) gene cause autosomal dominant kidney diseases characterized by juvenile-onset hyperuricemia, gout and progressive kidney failure, although the disease pathogenesis remains unclear. Here we show that targeted expression in transgenic mice of a mutation within the domain of 8 cysteines of THP in kidneys’ thick ascending limb (TAL) caused unfolded protein response in younger (1-month old) mice and apoptosis in older (12-month old) mice. While the young mice had urine concentration defects and polyuria, such defects progressively reversed in the older mice to marked oliguria, highly concentrated urine, fibrotic kidneys and reduced creatinine clearance. Both the young and the old transgenic mice had significantly higher serum uric acid and its catabolic product, allantoin, than age-matched wild-type mice. This THP mutation apparently caused primary defects in TAL by compromising the luminal translocation and reabsorptive functions of NKCC2 and ROMK and secondary responses in proximal tubules by upregulating NHE3 and URAT1. Our results strongly suggest that the progressive worsening of kidney functions reflects the accumulation of the deleterious effects of the misfolded mutant THP and the compensatory responses. Transgenic mice recapitulating human THP/uromodulin-associated kidney diseases could be used to elucidate their pathogenesis and test novel therapeutic strategies. PMID:29145399

Annual report, October 1, 1979-September 30, 1980

International Nuclear Information System (INIS)

1981-05-01

This annual report covers research progress on each of the following areas: (1) PLT device, (2) PDX, (3) spheromak, (4) smaller devices, (5) theory, (6) TFTR, (7) applied physics, (8) TFTR blanket module experiments, (9) advanced toroidal facility, (10) advanced projects design and analysis, (11) engineering, and (12) fabrication, operations and maintenance

Annual report, October 1, 1979-September 30, 1980

Energy Technology Data Exchange (ETDEWEB)

1981-05-01

This annual report covers research progress on each of the following areas: (1) PLT device, (2) PDX, (3) spheromak, (4) smaller devices, (5) theory, (6) TFTR, (7) applied physics, (8) TFTR blanket module experiments, (9) advanced toroidal facility, (10) advanced projects design and analysis, (11) engineering, and (12) fabrication, operations and maintenance. (MOW)

IEA Wind Energy Annual Report 2000

Energy Technology Data Exchange (ETDEWEB)

2001-05-01

The twenty-third IEA Wind Energy Annual Report reviews the progress during 2000 of the activities in the Implementing Agreement for Co-operation in the Research and Development on Wind Turbine Systems under the auspices of the International Energy Agency (IEA). The agreement and its program, which is known as IEA R&D Wind, is a collaborative venture among 19 contracting parties from 17 IEA member countries and the European Commission.

Progress at LAMPF, Clinton P. Anderson Meson Physics Facility, January-December 1984

International Nuclear Information System (INIS)

Allred, J.C.

1985-04-01

Progress at LAMPF is the annual progress report of the MP Division of the Los Alamos National Laboratory. The report includes brief reports on research done at LAMPF by researchers from other institutions and Los Alamos divisions. Abstracts of separate sections of the report were prepared separately for the data base

Southwestern Institute of Physics annual report (2000)

International Nuclear Information System (INIS)

2001-01-01

The research results and engineering progress of SWIP (Southwestern Institute of Physics) during the year of 2000 was summarized in this annual report. The contents divided into five parts: 1. tokamak experimental diagnoses and tokamak engineering; 2. fusion reactor and fusion reactor materials; 3. plasma theory and calculation; 4. technique development and application; 5. appendix 31 theses and presented in this report

Annual progress report on nuclear data 1992

Energy Technology Data Exchange (ETDEWEB)

Hansen, H H [ed.

1993-06-01

This is the 1992 annual report on nuclear data from the Central Bureau for Nuclear Measurements, Geel (Belgium). Work on standard neutron cross sections included {sup 235}U(n,f)/H(n,n) with Frisch gridded ionization chambers and using octacosanol samples. Mass, energy, and angular distribution of fission fragments for {sup 237}Np(n,f) from 0.5 to 5.5 MeV neutron energy. Alpha decay probabilities of {sup 239}Pu. In the area of nuclear data for fission technology, a measurement on the normalization of the {sup 239}Pu fission cross sections was performed. Parameters for 384 resonances in {sup 58}Ni and 350 resonances in {sup 60}Ni have been analyzed up to 1 MeV and 800 KeV, respectively. In the field of nuclear data for fusion technology, double differential neutron emission cross sections for {sup 9}Be(n,2n) for incident neutron energies between 0. 6 and 11.1 MeV have been reported. Extensive measurements of the neutron decay cross sections of {sup 207}Pb have been made. In the radionuclide metrology subproject contributions were made by the preparation of low energy x-ray standard sources, measurements of K- shell fluorescence yields, standardization of a {sup 152}Eu solution, evaluation of the second EUROMET intercomparison of {sup 192}Ir brachytherapy sources, and low level measurements on volcanic rock, archeological ceramics, soil and river sediments. Work was also reported in neutron metrology, major facilities upgrades, radiation physics, and support for a number of PhD projects.

Tau protein

DEFF Research Database (Denmark)

Frederiksen, Jette Lautrup Battistini; Kristensen, Kim; Bahl, Jmc

2011-01-01

Background: Tau protein has been proposed as biomarker of axonal damage leading to irreversible neurological impairment in MS. CSF concentrations may be useful when determining risk of progression from ON to MS. Objective: To investigate the association between tau protein concentration and 14......-3-3 protein in the cerebrospinal fluid (CSF) of patients with monosymptomatic optic neuritis (ON) versus patients with monosymptomatic onset who progressed to multiple sclerosis (MS). To evaluate results against data found in a complete literature review. Methods: A total of 66 patients with MS and/or ON from...... the Department of Neurology of Glostrup Hospital, University of Copenhagen, Denmark, were included. CSF samples were analysed for tau protein and 14-3-3 protein, and clinical and paraclinical information was obtained from medical records. Results: The study shows a significantly increased concentration of tau...

CAES Annual Report FY 2011

Energy Technology Data Exchange (ETDEWEB)

Kortny Rolston

2011-10-01

The Center for Advanced Energy Studies was created to lead research programs important to the nation, attract students and faculty to the Idaho universities and act as a catalyst for technology-based economic development. CAES is striving to meet those goals by continuing to develop its infrastructure and equipment capabilities, expand its research portfolio and bolster Idaho's energy workforce. This Annual Report details the progress CAES made in FY 2011 toward fulfilling its research, education and economic development missions.

Effects of low dose radiation on tumor apoptosis, cell cycle progression and changes of apoptosis-related protein bcl-2 in tumor-bearing mice

International Nuclear Information System (INIS)

Yu Hongsheng; Fei Conghe; Shen Fangzhen; Liang Jun

2003-01-01

Objective: To study the effect of low dose radiation (LDR) on tumor apoptosis, cell cycle progression and changes of apoptosis-related protein bcl-2 in tumor-bearing mice. Methods: Kunming stain male mice were implanted with S180 sarcoma cells in the left inguen subcutaneously as an in situ experimental animal model. Seven days after implantation, the mice were given 75 mGy whole-body γ-irradiation. At 24 and 48 h after irradiation, all mice were sacrificed to measure the tumor volume, and tumor cell apoptosis, cell cycle progression were analyzed by flow cytometry. The expression of apoptosis-related protein bcl-2 and the apoptotic rate of tumor cells were observed by immunohistochemistry and electron microscopy. Results: Tumor growth was significantly slowed down after LDR (P 1 phase and the expression of bcl-2 protein decreased at 24 h. Apoptotic rate of tumor cells increased significantly at 48 h after LDR. Conclusion: LDR could cause a G 1 -phase arrest and increase the apoptosis of tumor cells through the low level of apoptosis-related protein bcl-2 in the tumor-bearing mice. The organized immune function and anti-tumor ability are markedly increased after LDR. The study provides practical evidence of clinical application to cancer treatment

1986 Annual report on Low-Level Radioactive Waste Management progress

International Nuclear Information System (INIS)

1987-06-01

This report summarizes the progress of states and compact regions without low-level waste disposal sites (non-sited compact regions and nonmember states) in 1986 in siting new low-level waste disposal facilities. It also reports the volume of low-level waste received for disposal in 1986 by commercially operated low-level waste disposal facilities. 6 figs., 7 tabs

Quantitative assessment of smoking-induced emphysema progression in longitudinal CT screening for lung cancer

Science.gov (United States)

Suzuki, H.; Mizuguchi, R.; Matsuhiro, M.; Kawata, Y.; Niki, N.; Nakano, Y.; Ohmatsu, H.; Kusumoto, M.; Tsuchida, T.; Eguchi, K.; Kaneko, M.; Moriyama, N.

2015-03-01

Computed tomography has been used for assessing structural abnormalities associated with emphysema. It is important to develop a robust CT based imaging biomarker that would allow quantification of emphysema progression in early stage. This paper presents effect of smoking on emphysema progression using annual changes of low attenuation volume (LAV) by each lung lobe acquired from low-dose CT images in longitudinal screening for lung cancer. The percentage of LAV (LAV%) was measured after applying CT value threshold method and small noise reduction. Progression of emphysema was assessed by statistical analysis of the annual changes represented by linear regression of LAV%. This method was applied to 215 participants in lung cancer CT screening for five years (18 nonsmokers, 85 past smokers, and 112 current smokers). The results showed that LAV% is useful to classify current smokers with rapid progression of emphysema (0.2%/year, pemphysema in CT screening for lung cancer.

Smoldering multiple myeloma risk factors for progression

DEFF Research Database (Denmark)

Sørrig, Rasmus; Klausen, Tobias W; Salomo, Morten

2016-01-01

Several risk scores for disease progression in Smoldering Multiple Myeloma (SMM) patients have been proposed, however, all have been developed using single center registries. To examine risk factors for time to progression (TTP) to Multiple Myeloma (MM) for SMM we analyzed a nationwide population......-based cohort of 321 newly diagnosed SMM patients registered within the Danish Multiple Myeloma Registry between 2005 and 2014. Significant univariable risk factors for TTP were selected for multivariable Cox regression analyses. We found that both an M-protein ≥ 30g/l and immunoparesis significantly influenced......-high risk of transformation to MM. Using only immunoparesis and M-protein ≥ 30g/l, we created a scoring system to identify low, intermediate and high risk SMM. This first population-based study of SMM patients confirms that an M-protein ≥ 30g/l and immunoparesis remain important risk factors for progression...

Radiochemistry Division: Annual progress report for 1981

International Nuclear Information System (INIS)

Jayadevan, N.C.; Manohar, S.B.

1983-01-01

The progress report of the Radiochemistry Division of Bhabha Atomic Research Centre presents the research and development work carried out during 1981 in the form of individual summaries arranged under the headings: reactor fuel chemistry, heavy element chemistry, radioanalytical chemistry, and nuclear chemistry. Some of the highlights of the work are: (1) modification of the gelation set-up for making plutonium containing gel particles to get better yields of (U,Pu)O 2 containing up to 15% of plutonium, (2) studies on solvent extraction of Am(III), Cm(III), Bk(III) and Cf(III) by 1-phenyl-2-methyl-4-benzoyl pyrazolone-5 (HPMBP), (3) study of the radiation chemistry and photochemistry of aqueous solutions of plutonium, (4) study of crystal structure of uranyl oxalate and sulphates, (5) ESR study, thermoluminescence and spectral studies of americium doped SrSO 4 , phosphors, (6) determination of uranium and plutonium by spectrophotometry, mass spectroscopy and alpha spectroscopy, (7) determination of isotopic ratios of plutonium isotopes by gamma spectroscopy, (8) studies on several aspects of fission chemistry of 229 Th and 252 Cf, and (9) fabrication of a neutron well coincidence counter. (M.G.B.)

Localization of aPKC lambda/iota and its interacting protein, Lgl2, is significantly associated with lung adenocarcinoma progression.

Science.gov (United States)

Imamura, Naoko; Horikoshi, Yosuke; Matsuzaki, Tomohiko; Toriumi, Kentaro; Kitatani, Kanae; Ogura, Go; Masuda, Ryota; Nakamura, Naoya; Takekoshi, Susumu; Iwazaki, Masayuki

2013-12-20

Atypical protein kinase C lambda/iota (aPKC λ/ι) is expressed in several human cancers; however, the correlation between aPKC λ/ι localization and cancer progression in human lung adenocarcinoma (LAC) remains to be clarified. We found that patients with a high level of aPKC λ/ι expression in LAC had significantly shorter overall survival than those with a low level of aPKC λ/ι expression. In addition, localization of aPKC λ/ι in the apical membrane or at the cell-cell contact was associated with both lymphatic invasion and metastasis. The intercellular adhesion molecule, E-cadherin, was decreased in LACs with highly expressed aPKC λ/ι at the invasion site of tumor cells. This result suggested that the expression levels of aPKC λ/ι and E-cadherin reflect the progression of LAC. On double-immunohistochemical analysis, aPKC λ/ι and Lgl2, a protein that interacts with aPKC λ/ι, were co-localized within LACs. Furthermore, we found that Lgl2 bound the aPKC λ/ι-Par6 complex in tumor tissue by immune-cosedimentation analysis. Apical membrane localization of Lgl2 was correlated with lymphatic invasion and lymph node metastasis. These results thus indicate that aPKC λ/ι expression is altered upon the progression of LAC. This is also the first evidence to show aPKC λ/ι overexpression in LAC and demonstrates that aPKC λ/ι localization at the apical membrane or cell-cell contact is associated with lymphatic invasion and metastasis of the tumor.

Research in radiobiology. Annual report, Internal Irradiation Program

International Nuclear Information System (INIS)

Miller, S.C.; Buster, D.S.

1985-01-01

The annual progress report for the Radiobiology Division of the University of Utah College of Medicine is presented. Summaries of twenty-four projects concerning the metabolism, dosimetry and toxicity of a variety of actinide elements in beagles or rats are given. Individual papers within this report have been separately indexed and abstracted for the data base

Slow rate of progression of grade 1 and 2+ aortic regurgitation.

Science.gov (United States)

Patel, Reena; Kamath, Ashvin; Varadarajan, Padmini; Krishnan, Srikanth; Pai, Ramdas G

2012-05-01

Although the progression of aortic stenosis has been well studied, the rate of progression of aortic regurgitation (AR) has not been definitively established. Further data would be valuable for clinical decision-making in patients with milder degrees of AR undergoing non-aortic valve cardiac surgery. Hence, this point was investigated in a large cohort of patients with grade 1 or 2+ AR. The authors' echocardiographic database acquired between 1993 and 2007 was screened for patients with grade 1 or 2+ AR who had undergone follow up echocardiography at least one year later. The AR severity was graded as 1 to 4+, and any annual changes in AR grade were monitored. Among a total of 4,128 patients identified, 3,266 had grade 1+ AR and 862 had grade 2+ AR on the initial echocardiogram: the mean age was 67 +/- 15 years, and the duration of follow up was 4.2 +/- 2.7 years. Of those patients initially with grade 1+ AR, 95% showed no change in AR over a mean interval of 4.2 years, with an annual average increase in AR grade of 0.04. Of those patients initially with grade 2+ AR, 90% showed no change over this period, with an annual average increase in grade of 0.07. In the entire cohort, the AR progression correlated positively with age (p = 0.03), ventricular septal thickness (p grade 1 or 2+ AR in the absence of any higher risk for progression, such as grade 2+ AR combined with any degree of aortic stenosis and advanced age.

The effect of inhaled corticosteroids on the development of emphysema in smokers assessed by annual computed tomography

DEFF Research Database (Denmark)

Shaker, Saher B; Dirksen, Asger; Ulrik, Charlotte S

2009-01-01

The objective was to evaluate the effect of inhaled corticosteroids on disease progression in smokers with moderate to severe chronic obstructive pulmonary disease (COPD), as assessed by annual computed tomography (CT) using lung density (LD) measurements. Two hundred and fifty-four current smokers...... (-54 mL) and placebo (-56 mL) (p = 0.89). Long-term budesonide inhalation shows a non-significant trend towards reducing the progression of emphysema as determined by the CT-derived 15th percentile lung density from annual CT scans in current smokers with moderate to severe COPD....

Inhalation Toxicology Research Institute. Annual report, October 1, 1992--September 30, 1993

Energy Technology Data Exchange (ETDEWEB)

Nikula, K.J.; Belinsky, S.A.; Bradley, P.L. [eds.

1993-11-01

This annual report for the Inhalation Toxicology Research Institute for 1992-1993 consists of 60 individual reports prepared separately by investigators describing progress in their own projects. Most papers are 2-5 pages long.

Properties and regulation of biosynthesis of cottonseed storage proteins. Comprehensive progress report, December 1, 1976 to September 1, 1979

Energy Technology Data Exchange (ETDEWEB)

Dure, III, L S

1979-01-01

The regulation of gene expression in cotton seed embryogenesis was studied by attempting to define what gene products are likely to be highly regulated during this developmental progression. The flow of nitrogen into the free amino acids pools of the developing cotyledons, and into the principal nitrogen nutritional reserve of the seed, the storage proteins was measured. This was continued by following the flow of nitrogen from the storage proteins to the principal exported amino acid asparagine that occurs during the first several days of germination. In this fashion the rise and fall of certain enzymes of amino acid intermediary metabolism could be postulated, and in some cases, verified. The subsets of abundant mRNAs whose appearance and disappearance coincided with developmental events in cotyledon embryogenesis/germination with the short range goal of identifying proteins/enzyme activities were delineated as well as their mRNAs that represent specific developmental stages and the long range goal of using these representatives as probes for studying the mechanisms controlling the rise and fall of these mRNAs and their protein products.

Safety-related LWR research. Annual report 1989

International Nuclear Information System (INIS)

1990-11-01

The main topics in this annual report 1989 are phenomena of heavy fuel damage and single aspects of a core meltdown accident. The examined single aspects refer to aerosol behavior and filter engineering and to methods for assessment and minimization of the radiological consequences of reactor accidents. Different contributions to selected, safety-related problems of an advanced pressurized-water reactor complete the topic spectrum. The annual report 1989 describes the progress of the research work wich was carried out in the area of safety research by institutes and departments of the KfK, and on behalf of the KfK by external institutions. The individual contributions represent the status of work at the end of the year under review, 1989. (orig./HP) [de

1992 annual report on low-level radioactive waste management progress

International Nuclear Information System (INIS)

1993-11-01

This report summarizes the progress States and compact regions made during 1992 in establishing new low-level radioactive waste disposal facilities. It also provides summary information on the volume of low-level radioactive waste received for disposal in 1992 by commercially operated low-level radioactive waste disposal facilities. This report is in response to section 7 (b) of the Low-Level Radioactive Waste Policy Act

Walter Reed Army Institute of Research Annual Progress Report, Fiscal Year 1981.

Science.gov (United States)

1981-10-01

erythrocytes. American Society of Nephrology (14th Annual Meeting). Articles Published, In Press or In Review 1. Webster HK, Haut MJ, Martin LK...is assessed by determining the extent of sequence variation in inmunologically unique variant-specific surface coat glycoproteina Peptide mapping of...Weissman, W.: Cholinergic Stimulated Ca+4 - Uptake and cGMP Formation in Human Red Blood Cells. Clln.cal Research 29, 1981. Articles Published, In Press or

A SEL1L mutation links a canine progressive early-onset cerebellar ataxia to the endoplasmic reticulum-associated protein degradation (ERAD machinery.

Directory of Open Access Journals (Sweden)

Kaisa Kyöstilä

Full Text Available Inherited ataxias are characterized by degeneration of the cerebellar structures, which results in progressive motor incoordination. Hereditary ataxias occur in many species, including humans and dogs. Several mutations have been found in humans, but the genetic background has remained elusive in dogs. The Finnish Hound suffers from an early-onset progressive cerebellar ataxia. We have performed clinical, pathological, and genetic studies to describe the disease phenotype and to identify its genetic cause. Neurological examinations on ten affected dogs revealed rapidly progressing generalized cerebellar ataxia, tremors, and failure to thrive. Clinical signs were present by the age of 3 months, and cerebellar shrinkage was detectable through MRI. Pathological and histological examinations indicated cerebellum-restricted neurodegeneration. Marked loss of Purkinje cells was detected in the cerebellar cortex with secondary changes in other cortical layers. A genome-wide association study in a cohort of 31 dogs mapped the ataxia gene to a 1.5 Mb locus on canine chromosome 8 (p(raw = 1.1x10(-7, p(genome = 7.5x10(-4. Sequencing of a functional candidate gene, sel-1 suppressor of lin-12-like (SEL1L, revealed a homozygous missense mutation, c.1972T>C; p.Ser658Pro, in a highly conserved protein domain. The mutation segregated fully in the recessive pedigree, and a 10% carrier frequency was indicated in a population cohort. SEL1L is a component of the endoplasmic reticulum (ER-associated protein degradation (ERAD machinery and has not been previously associated to inherited ataxias. Dysfunctional protein degradation is known to cause ER stress, and we found a significant increase in expression of nine ER stress responsive genes in the cerebellar cortex of affected dogs, supporting the pathogenicity of the mutation. Our study describes the first early-onset neurodegenerative ataxia mutation in dogs, establishes an ERAD-mediated neurodegenerative

Utah System of Higher Education 2015-16 Annual Report

Science.gov (United States)

Utah System of Higher Education, 2016

2016-01-01

This annual report describes Utah System of Higher Education's progress in the 2015-2016 academic year in the following areas: (1) Strategic plan; (2) Enrollment and completion; (3) Paying for college; (4) Funding higher education; (5) College preparation; (6) Concurrent enrollment and math; (7) Outreach and access; and (8) Industry and the…

Charbonnages de France. 1998 annual report

International Nuclear Information System (INIS)

1998-01-01

This annual report of the Charbonnages de France (CdF) group presents the financial results of the group for 1998: coal market, CdF's financial results (turnover, exploitation result, financial result, debt); power production (Snet, Cerchar, Surschiste, Sidec, and CdF Ingenierie activities); coal industry activities (coal mines, coke factories, coal products, environment); progressive ceasing of coal extraction (safety, manpower, reduction of working time, training, management of abandoned sites, rehabilitation, cleansing); management of industrialization and patrimony. (J.S.)

Studies of radiation and chemical toxicity. Progress report

International Nuclear Information System (INIS)

1986-01-01

Annual report for the Studies of Radiation and Chemical Toxicity Program at the University of Rochester is presented. Progress is reported on four projects: Neurobehavorial Toxicity of Organometallic Fuel Additives, Mechanisms of Permanent and Delayed Pathologic Effects of Ionizing Radiation, Solid State Radiation Chemistry of the DNA Backbone, and Pulmonary Biochemistry

Southwestern Institute of Physics annual report 2001

International Nuclear Information System (INIS)

2002-01-01

In the year 2001, significant progresses in the engineering construction of the HL-2A tokamak were made at the Southwestern Institute of Physics (SWIP). At the same time, the research projects from Nuclear Energy Development Foundation, the National Defense Basic Research Foundation and the National Science Foundation of China were completely fulfilled. In addition 283 papers and reports were contributed, among them, 67 are included in the Annual Report

Human genetic marker for resistance to radiations and chemicals. 1998 annual progress report

International Nuclear Information System (INIS)

Lieberman, H.B.

1998-01-01

'The broad objective of the project is to understand the molecular basis for the response of cells to radiations and chemicals, with the pragmatic goal of being able to identify human subpopulations that are exceptionally sensitive to DNA damaging agents. The project focuses on HRAD9, a human orthologue of the fission yeast Schizosaccharomyces pombe gene rad9. S. pombe rad9::ura4+ mutant cells are highly sensitive to ionizing radiation, UV and many chemicals, such as the DNA synthesis inhibitor hydroxyurea. They also lack the ability to delay cycling transiently in S phase or in G2 following a block in DNA replication or after incurring DNA damage, respectively -i.e., they lack checkpoint controls. The attempt by mutant cells to progress through mitosis in the absence of fully intact DNA accounts at least in part for their sensitivity to DNA damaging agents. Cells bearing rad9::ura4+ also aberrantly regulate UVDE, an enzyme that participates in a secondary DNA excision repair pathway. The key role played by S. pombe rad9 in promoting resistance to chemicals and radiations suggests that the evolutionarily conserved human cognate also has important functions in mammals. The first set of aims in this proposal centers on characterizing the structure and expression of HRAD9, to assess structure/function relationships and potentially link protein activity to a specific tissue. The next set of aims focuses on determining the role of HRAD9 in radio/chemoresponsiveness and cancer.'

Dynamic Changes of Neuroskeletal Proteins in DRGs Underlie Impaired Axonal Maturation and Progressive Axonal Degeneration in Type 1 Diabetes

Directory of Open Access Journals (Sweden)

Hideki Kamiya

2009-01-01

Full Text Available We investigated mechanisms underlying progressive axonal dysfunction and structural deficits in type 1 BB/Wor-rats from 1 week to 10 month diabetes duration. Motor and sensory conduction velocities were decreased after 4 and 6 weeks of diabetes and declined further over the remaining 9 months. Myelinated sural nerve fibers showed progressive deficits in fiber numbers and sizes. Structural deficits in unmyelinated axonal size were evident at 2 month and deficits in number were present at 4 mo. These changes were preceded by decreased availability of insulin, C-peptide and IGF-1 and decreased expression of neurofilaments and β-III-tubulin. Upregulation of phosphorylating stress kinases like Cdk5, p-GSK-3β, and p42/44 resulted in increased phosphorylation of neurofilaments. Increasing activity of p-GSK-3β correlated with increasing phosphorylation of NFH, whereas decreasing Cdk5 correlated with diminishing phosphorylation of NFM. The data suggest that impaired neurotrophic support results in sequentially impaired synthesis and postranslational modifications of neuroskeletal proteins, resulting in progressive deficits in axonal function, maturation and size.

C-Reactive Protein Predicts Progression of Peripheral Arterial Disease in Patients with Type 2 Diabetes: A 5-Year Follow-Up Study

Directory of Open Access Journals (Sweden)

Popović Ljiljana

2014-09-01

Full Text Available Background: Previous studies have indicated that high sensitivity C-reactive protein (hs-CRP is a risk factor for the peripheral arterial disease (PAD in diabetes. This study aimed to evaluate the possible predictive significance of hs-CRP for the development and progression of PAD in patients with type 2 diabetes (T2D.

3-D spectral IP imaging: Non-invasive characterization of contaminant plumes. 1998 annual progress report

International Nuclear Information System (INIS)

Lesmes, D.; Morgan, F.D.; Rodi, W.

1998-01-01

'The overall objective of this project is to develop the scientific basis for characterizing contaminant plumes in the earth''s subsurface using field measurements of induced polarization (IP) effects. Three specific objectives towards this end are: (1) understanding IP at the laboratory level through measurements of complex resistivity as a function of frequency in rock and soil samples with varying pore geometries, pore fluid conductivities and saturations, and contaminant chemistries and concentrations; (2) developing effective data acquisition techniques for measuring the critical IP responses (time domain or frequency domain) in the field; (3) developing modeling and inversion algorithms that permit the interpretation of field IP data in terms of subsurface geology and contaminant plume properties. The authors laboratory experiments to date are described in Appendices A and B, which consist of two papers submitted to the annual SAGEEP conference (Frye et al., 1998; Sturrock et al., 1998). The experiments involved measurements of complex resistivity vs. frequency on a suite of brine saturated sandstone samples. In one set of experiments, the fluid chemistry (pH, ionic strength, and cation type) was varied. In a second set of experiments, the microgeometry of the rock matrix was varied. The experiments showed that spectral IP responses are sensitive to subtle variations in both the solution chemistry and rock microgeometry. The results demonstrate that spectral IP responses have the potential of being sensitive indicators of in-situ chemistry and microgeometry, the latter of which may be related to the hydraulic properties. Data Acquisition The authors have been looking in some detail at the effects of electromagnetic coupling and how to practically deal with it. In this area, the results to date are summarized in Vandiver (1998). The progress in the development of modeling and inversion algorithms for IP is described in Appendix C, a paper submitted to the

LLE 2009 annual report, October 2008-September 2009

Energy Technology Data Exchange (ETDEWEB)

none, none

2010-01-01

The fiscal year ending September 2009 (FY2009) concluded the second year of the third five-year renewal of Cooperative Agreement DE-FC52-08NA28302 with the U.S. Department of Energy (DOE). This annual report summarizes progress in inertial fusion research at the Laboratory for Laser Energetics (LLE) during the past fiscal year. It also reports on LLE’s progress on laboratory basic science research; laser, optical materials, and advanced technology development; operation of OMEGA and OMEGA EP for the National Laser Users’ Facility (NLUF), and other external users; and programs focusingon the education of high school, undergraduate, and graduate students during the year.

Annual report on major results and progress of Fusion Research and Development Directorate of JAEA from April 1, 2006 to March 31, 2007

International Nuclear Information System (INIS)

Suzuki, Satoshi; Ishii, Yasutomo; Sukegawa, Atsuhiko; Iwai, Yasunori; Nakamura, Hiroo; Sugie, Tatsuo

2008-08-01

This annual report provides an overview of major results and progress on research and development (R and D) activities at Fusion Research and Development Directorate of Japan Atomic Energy Agency (JAEA) from April 1, 2006 to March 31, 2007, including those performed in collaboration with other research establishments of JAEA, research institutes, and universities. In JT-60, as a result of ferritic steel tiles (FSTs) installation to reduce the toroidal field ripple and the application of the real time current profile control, high boot strap current fraction (∼0.7) has successfully been sustained about 8 s. In addition, the conceptual design of JT-60SA, which was placed as a combined project of JA-EU Satellite Tokamak Programme under the Broader Approach Programme and JAEA's programme for national use, was progressed. In theoretical and analytical researches, studies on ITB events and their triggers, plasma shape effect on edge stability and driven magnetic island evolution in rotating plasmas were progressed. In the NEXT project, computer simulations of the plasma turbulence were progressed. In fusion reactor technologies, R and Ds for ITER and fusion DEMO plants have been carried out. For ITER, a steady state operation of the 170GHz gyrotron up to 10min with 0.82MW was demonstrated. Also current density of the neutral beam injector has been extended to 146A/m 2 at 0.84MeV. In the ITER Test Blanket Module (TBM), designs and R and Ds of Water and Helium Cooled Solid Breeder TBMs including tritium breeder/multiplier materials were progressed. Tritium processing technology for breeding blankets and neutronics integral experiments with a blanket mockup were also progressed. For ITER and DEMO blankets, studies on neutron irradiation effects and ion irradiation effects on F82H steel characteristics were continued using HFIR, TIARA and so on. In the IFMIF program, transitional activities to EVEDA were continued. In the ITER Program, under the framework of the ITER

Annual progress report 1988, operation of the high flux reactor

International Nuclear Information System (INIS)

1989-01-01

In 1988 the High Flux Reactor Petten was routinely operated without any unforeseen event. The availability was 99% of scheduled operation. Utilization of the irradiation positions amounted to 80% of the practical occupation limit. The exploitation pattern comprised nuclear energy deployment, fundamental research with neutrons, and radioisotope production. General activities in support of running irradiation programmes progressed in the normal way. Development activities addressed upgrading of irradiation devices, neutron radiography and neutron capture therapy

Particle-beam-fusion progress report, July 1979 through December 1979

International Nuclear Information System (INIS)

1981-01-01

The following chapters are included in this semi-annual progress report: (1) fusion target studies, (2) target experiments, (3) particle-beam source developments, (4) particle beam experiments, (5) pulsed power, (6) pulsed power applications, and (7) electron beam fusion accelerator project

Annual progress report on the NSRR experiments, (19)

International Nuclear Information System (INIS)

1991-08-01

Fuel behavior studies in simulated reactivity initiated accident (RIA) conditions have been performed by utilizing Nuclear Safety Research Reactor (NSRR) since October 1975. This report describes the results obtained from experiments performed from January through December, 1987. A total of 38 tests was carried out during this period : those are 5 NSRR standard fuel test, 6 fuel design parameter tests (2 fuel tests with iodine, 3 tests with SUS claddings, and 1 for destructive force measurement test), 7 cooling parameter tests (3 test with flow tube and 4 bundle tests), 8 advanced type fuel tests (1 NRC tests, 5 PCI-resistant fuel tests, 2 pressurized hollow fuel tests), 1 high pressure / high temperature tests, 2 high temperature / high pressure loop tests, 3 high temperature flooding tests, 3 fuel motion observation tests, and 3 miscellaneous atmospheric pressure capsule tests (1 fuel damage test, 2 acceleration tests). The progress of computer code development is also described. (author)

[Salt intake and the progression of renal failure in patients with chronic kidney disease].

Science.gov (United States)

Amaha, Mayuko; Ohashi, Yasushi; Sakai, Ken; Aikawa, Atsushi; Mizuiri, Sonoo

2010-01-01

Salt intake not only elevates the levels of blood pressure, glomerular capillary pressure and proteinuria, but also increases oxidative stress within the renal cortex in animal models. We examined the effect of salt intake on the rate of renal function decline, urinary protein and oxidative stress in patients with chronic kidney disease (CKD). Clinical data including systolic blood pressure (SBP)and diastolic blood pressure (DBP), serum creatinine, uric acid, total cholesterol, triglyceride, urinary protein, salt intake, protein intake of non-diabetic CKD 53 patients were observed for one year. At the end of the observation period, we measured 8-hydroxydeoxy guanosine (8-OHdG) in spot urine. We calculated the slope of reciprocal serum creatinine as the rate of renal function decline (delta1/Cr). We then investigated the relationship between those clinical factors and delta1/Cr, and urinary 8-OHdG, and also selected clinical factors that significantly influence delta1/Cr and urinary 8-OHdG by stepwise multiple regression analysis. In addition, we investigated the gender difference in urinary 8-OHdG. Annual mean SBP and DBP of all patients were 121.5 +/- 9.3 mmHg and 72.5+/- 6.2 mmHg, respectively. delta1/Cr was negatively correlated with salt intake, urinary protein and urinary protein was a significant predictor of delta1/Cr in a multiple regression analysis. Salt intake was positively correlated with protein intake and urinary protein. Urinary 8-OHdG of all patients was positively correlated with urinary protein and it was a significant predictor. Urinary 8-OHdG of male patients was positively correlated with salt intake and was a significant predictor; in female patients, it was positively correlated with urinary protein and total cholesterol and these two factors were significant predictors. Salt intake increases urinary protein and promotes the progression of renal failure in CKD patients.

Analytical Chemistry Division annual progress report for period ending December 31, 1979

International Nuclear Information System (INIS)

Shults, W.D.; Lyon, W.S.

1980-05-01

The progress is reported in the following sections: analytical methodology, mass and emission spectrometry, technical support, bio-organic analysis, nuclear and radiochemical analysis, and quality assurance

Progress towards the development of SH2 domain inhibitors.

Science.gov (United States)

Kraskouskaya, Dziyana; Duodu, Eugenia; Arpin, Carolynn C; Gunning, Patrick T

2013-04-21

Src homology 2 (SH2) domains are 100 amino acid modular units, which recognize and bind to tyrosyl-phosphorylated peptide sequences on their target proteins, and thereby mediate intracellular protein-protein interactions. This review summarizes the progress towards the development of synthetic agents that disrupt the function of the SH2 domains in different proteins as well as the clinical relevance of targeting a specific SH2 domain. Since 1986, SH2 domains have been identified in over 110 human proteins, including kinases, transcription factors, and adaptor proteins. A number of these proteins are over-activated in many diseases, including cancer, and their function is highly dependent on their SH2 domain. Thus, inhibition of a protein's function through disrupting that of its SH2 domain has emerged as a promising approach towards the development of novel therapeutic modalities. Although targeting the SH2 domain is a challenging task in molecular recognition, the progress reported here demonstrates the feasibility of such an approach.

Analytical Chemistry Division annual progress report for period ending December 31, 1979

Energy Technology Data Exchange (ETDEWEB)

Shults, W.D.; Lyon, W.S. (ed.)

1980-05-01

The progress is reported in the following sections: analytical methodology, mass and emission spectrometry, technical support, bio-organic analysis, nuclear and radiochemical analysis, and quality assurance. (DLC)

1989 Annual report on low-level radioactive waste management progress

International Nuclear Information System (INIS)

1990-10-01

This report summarizes the progress during 1989 of states and compacts in establishing new low-level radioactive waste disposal facilities. It also provides summary information on the volume of low-level waste received for disposal in 1989 by commercially operated low-level waste disposal facilities. This report is in response to Section 7(b) of Title I of Public Law 99--240, the Low-Level Radioactive Waste Policy Amendments Act of 1985. 2 figs., 5 tabs

Effect of low-protein diet supplemented with keto acids on progression of chronic kidney disease.

Science.gov (United States)

Garneata, Liliana; Mircescu, Gabriel

2013-05-01

Hypoproteic diets are most often discussed for patients with chronic kidney disease (CKD) who do not receive dialysis. A very low-protein diet supplemented with ketoanalogues of essential amino acids (keto-diet) proved effective in ameliorating metabolic disturbances of advanced CKD and delaying the initiation of dialysis without deleterious effects on nutritional status. Several recent studies report that the keto-diet could also slow down the rate of decline in renal function, with better outcomes after the initiation of dialysis. Results of a single-center randomized controlled trial addressing the rate of CKD progression revealed a 57% slower decline in renal function with the keto-diet compared with a conventional low-protein diet (LPD). The keto-diet allowed the safe management of selected patients with stage 4-5 CKD, delaying dialysis for almost 1 year, with a major impact on patient quality of life and health expenditures. Therefore, the keto-diet could be a link in the integrated care model. Careful selection of patients, nutritional monitoring, and dietary counseling are required. Copyright © 2013 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

Chemistry Division annual progress report for period ending January 31, 1984

Energy Technology Data Exchange (ETDEWEB)

1984-05-01

Progress is reported in the following fields: coal chemistry, aqueous chemistry at high temperatures and pressures, geochemistry, high-temperature chemistry and thermodynamics of structural materials, chemistry of transuranium elements and compounds, separations chemistry, elecrochemistry, catalysis, chemical physics, theoretical chemistry, nuclear waste chemistry, chemistry of hazardous chemicals, and thermal energy storage.

University of Florida, University research program in robotics. Annual technical progress report

International Nuclear Information System (INIS)

Crane, C.D. III; Tulenko, J.S.

1994-05-01

Progress is reported in the areas of environmental hardening, database, world modeling, vision, man-machine interface, advanced liquid metal reactor inspection robot, and articulated transporter/manipulator system (ATMS) development

University of Florida, University research program in robotics. Annual technical progress report

Energy Technology Data Exchange (ETDEWEB)

Crane, C.D. III; Tulenko, J.S.

1994-05-01

Progress is reported in the areas of environmental hardening, database, world modeling, vision, man-machine interface, advanced liquid metal reactor inspection robot, and articulated transporter/manipulator system (ATMS) development.

Targeting the extracellular matrix to disrupt cancer progression

Directory of Open Access Journals (Sweden)

Freja Albjerg Venning

2015-10-01

Full Text Available Metastatic complications are responsible for more than 90% of cancer related deaths. The progression from an isolated tumor to disseminated metastatic disease is a multi-step process, with each step involving intricate cross-talk between the cancer cells and their non-cellular surroundings, the extracellular matrix (ECM. Many ECM proteins are significantly de-regulated during the progression of cancer, causing both biochemical and biomechanical changes that together promote the metastatic cascade. In this review, the influence of several ECM proteins on these multiple steps of cancer spread is summarized. In addition, we highlight the promising (pre-clinical data showing benefits of targeting these ECM macromolecules to prevent cancer progression.

Experimental medium energy physics: Annual progress report June 1987--May 1988

International Nuclear Information System (INIS)

1988-01-01

This report discusses progress in experimental medium energy physics at Carnegie Mellon University. Some of the topics covered are: search for the ξ(2230); hyperon-antihyperon production studies; relativistic proton-nucleus and heavy ion-nucleus collisions; H dibaryon physics; hypernuclear physics research; pion physics; H particle experiment design and development; and electron scattering

FY 2005 Annual Progress Report for the DOE Hydrogen Program

Energy Technology Data Exchange (ETDEWEB)

None

2005-10-01

In cooperation with industry, academia, national laboratories, and other government agencies, the Department of Energy's Hydrogen Program is advancing the state of hydrogen and fuel cell technologies in support of the President's Hydrogen Fuel Initiative. The initiative seeks to develop hydrogen, fuel cell, and infrastructure technologies needed to make it practical and cost-effective for Americans to choose to use fuel cell vehicles by 2020. Significant progress was made in fiscal year 2005 toward that goal.

United States Department of Education: Annual Accountability Report, Fiscal Year 1995.

Science.gov (United States)

Department of Education, Washington, DC.

Fiscal year 1995 marks the first year during which an independent audit was conducted of the U.S. Department of Education's financial statements. This first annual accountability report describes the department's history, current mission, priorities, and progress. It highlights the department's program and fiscal accomplishments and describes…

Protein Biomarkers for Early Detection of Pancreatic Ductal Adenocarcinoma: Progress and Challenges.

Science.gov (United States)

Root, Alex; Allen, Peter; Tempst, Paul; Yu, Kenneth

2018-03-07

Approximately 75% of patients with pancreatic ductal adenocarcinoma are diagnosed with advanced cancer, which cannot be safely resected. The most commonly used biomarker CA19-9 has inadequate sensitivity and specificity for early detection, which we define as Stage I/II cancers. Therefore, progress in next-generation biomarkers is greatly needed. Recent reports have validated a number of biomarkers, including combination assays of proteins and DNA mutations; however, the history of translating promising biomarkers to clinical utility suggests that several major hurdles require careful consideration by the medical community. The first set of challenges involves nominating and verifying biomarkers. Candidate biomarkers need to discriminate disease from benign controls with high sensitivity and specificity for an intended use, which we describe as a two-tiered strategy of identifying and screening high-risk patients. Community-wide efforts to share samples, data, and analysis methods have been beneficial and progress meeting this challenge has been achieved. The second set of challenges is assay optimization and validating biomarkers. After initial candidate validation, assays need to be refined into accurate, cost-effective, highly reproducible, and multiplexed targeted panels and then validated in large cohorts. To move the most promising candidates forward, ideally, biomarker panels, head-to-head comparisons, meta-analysis, and assessment in independent data sets might mitigate risk of failure. Much more investment is needed to overcome these challenges. The third challenge is achieving clinical translation. To moonshot an early detection test to the clinic requires a large clinical trial and organizational, regulatory, and entrepreneurial know-how. Additional factors, such as imaging technologies, will likely need to improve concomitant with molecular biomarker development. The magnitude of the clinical translational challenge is uncertain, but interdisciplinary

Protein Biomarkers for Early Detection of Pancreatic Ductal Adenocarcinoma: Progress and Challenges

Directory of Open Access Journals (Sweden)

Alex Root

2018-03-01

Full Text Available Approximately 75% of patients with pancreatic ductal adenocarcinoma are diagnosed with advanced cancer, which cannot be safely resected. The most commonly used biomarker CA19-9 has inadequate sensitivity and specificity for early detection, which we define as Stage I/II cancers. Therefore, progress in next-generation biomarkers is greatly needed. Recent reports have validated a number of biomarkers, including combination assays of proteins and DNA mutations; however, the history of translating promising biomarkers to clinical utility suggests that several major hurdles require careful consideration by the medical community. The first set of challenges involves nominating and verifying biomarkers. Candidate biomarkers need to discriminate disease from benign controls with high sensitivity and specificity for an intended use, which we describe as a two-tiered strategy of identifying and screening high-risk patients. Community-wide efforts to share samples, data, and analysis methods have been beneficial and progress meeting this challenge has been achieved. The second set of challenges is assay optimization and validating biomarkers. After initial candidate validation, assays need to be refined into accurate, cost-effective, highly reproducible, and multiplexed targeted panels and then validated in large cohorts. To move the most promising candidates forward, ideally, biomarker panels, head-to-head comparisons, meta-analysis, and assessment in independent data sets might mitigate risk of failure. Much more investment is needed to overcome these challenges. The third challenge is achieving clinical translation. To moonshot an early detection test to the clinic requires a large clinical trial and organizational, regulatory, and entrepreneurial know-how. Additional factors, such as imaging technologies, will likely need to improve concomitant with molecular biomarker development. The magnitude of the clinical translational challenge is uncertain, but

Progress in proton-detected solid-state NMR (SSNMR): Super-fast 2D SSNMR collection for nano-mole-scale proteins

Science.gov (United States)

Ishii, Yoshitaka; Wickramasinghe, Ayesha; Matsuda, Isamu; Endo, Yuki; Ishii, Yuji; Nishiyama, Yusuke; Nemoto, Takahiro; Kamihara, Takayuki

2018-01-01

Proton-detected solid-state NMR (SSNMR) spectroscopy has attracted much attention due to its excellent sensitivity and effectiveness in the analysis of trace amounts of amyloid proteins and other important biological systems. In this perspective article, we present the recent sensitivity limit of 1H-detected SSNMR using "ultra-fast" magic-angle spinning (MAS) at a spinning rate (νR) of 80-100 kHz. It was demonstrated that the high sensitivity of 1H-detected SSNMR at νR of 100 kHz and fast recycling using the paramagnetic-assisted condensed data collection (PACC) approach permitted "super-fast" collection of 1H-detected 2D protein SSNMR. A 1H-detected 2D 1H-15N correlation SSNMR spectrum for ∼27 nmol of a uniformly 13C- and 15N-labeled GB1 protein sample in microcrystalline form was acquired in only 9 s with 50% non-uniform sampling and short recycle delays of 100 ms. Additional data suggests that it is now feasible to detect as little as 1 nmol of the protein in 5.9 h by 1H-detected 2D 1H-15N SSNMR at a nominal signal-to-noise ratio of five. The demonstrated sensitivity is comparable to that of modern solution protein NMR. Moreover, this article summarizes the influence of ultra-fast MAS and 1H-detection on the spectral resolution and sensitivity of protein SSNMR. Recent progress in signal assignment and structural elucidation by 1H-detected protein SSNMR is outlined with both theoretical and experimental aspects.

Report to Congress: 1995 Annual report on low-level radioactive waste management progress

International Nuclear Information System (INIS)

1996-06-01

This report is prepared in response to the Low-Level Radioactive Waste Policy Act, Public Law 96-573, 1980, as amended by the Low-Level Radioactive Waste Policy Amendments Act of 1985, Public Law 99-240. The report summarizes the progress of states and compact regions during calendar year 1995 in establishing new disposal facilities for commercially-generated low-level radioactive waste. The report emphasizes significant issues and events that have affected progress, and also includes an introduction that provides background information and perspective on United States policy for low-level radioactive waste disposal

Paul Scherrer Institut annual report 1996. Annex IIIB: applied solid state physics

Energy Technology Data Exchange (ETDEWEB)

Kuse, D. [ed.] [Paul Scherrer Inst. (PSI), Villigen (Switzerland)

1997-09-01

The annual report presents F3B highlights and reports on progress achieved during 1966 in the field of nanotechnology, semiconductor quantum structure, optoelectronic devices, micro- and integrated optics, optical metrology, new installations. A list of publications is also presented. figs., tabs., refs.

Paul Scherrer Institut annual report 1996. Annex IIIB: applied solid state physics

International Nuclear Information System (INIS)

Kuse, D.

1997-01-01

The annual report presents F3B highlights and reports on progress achieved during 1966 in the field of nanotechnology, semiconductor quantum structure, optoelectronic devices, micro- and integrated optics, optical metrology, new installations. A list of publications is also presented. figs., tabs., refs

A longitudinal study of motor, oculomotor and cognitive function in progressive supranuclear palsy.

Directory of Open Access Journals (Sweden)

Boyd C P Ghosh

Full Text Available We studied the annual change in measures of motor, oculomotor and cognitive function in progressive supranuclear palsy. This had twin objectives, to assess the potential for clinical parameters to monitor disease progression in clinical trials and to illuminate the progression of pathophysiology.Twenty three patients with progressive supranuclear palsy (Richardson's syndrome were compared to 22 matched controls at baseline and 16 of these patients compared at baseline and one year using: the progressive supranuclear palsy rating scale; the unified Parkinson's disease rating scale; the revised Addenbrooke's cognitive examination; the frontal assessment battery; the cubes section of the visual object and space perception battery; the Hayling and Brixton executive tests; and saccadic latencies.Patients were significantly impaired in all domains at baseline. However, cognitive performance was maintained over a year on the majority of tests. The unified Parkinson's disease rating scale, saccadic latency and progressive supranuclear palsy rating scale deteriorated over a year, with the latter showing the largest change. Power estimates indicate that using the progressive supranuclear palsy rating scale as an outcome measure in a clinical trial would require 45 patients per arm, to identify a 50% reduction in rate of decline with 80% power.Motor, oculomotor and cognitive domains deteriorate at different rates in progressive supranuclear palsy. This may be due to differential degeneration of their respective cortical-subcortical circuits, and has major implications for the selection of outcome measures in clinical trials due to wide variation in sensitivity to annual rates of decline.

LLNL NESHAPs, 1993 annual report

International Nuclear Information System (INIS)

Harrach, R.J.; Surano, K.A.; Biermann, A.H.; Gouveia, F.J.; Fields, B.C.; Tate, P.J.

1994-06-01

The standard defined in NESHAPSs CFR Part 61.92 limits the emission of radionuclides to the ambient air from DOE facilities to those that would cause any member of the public to receive in any year an effective dose equivalent of 10 mrem. In August 1993 DOE and EPA signed a Federal Facility Compliance Agreement which established a schedule of work for LLNL to perform to demonstrate compliance with NESHAPs, 40 CFR part 61, Subpart H. The progress in LLNL's NESHAPs program - evaluations of all emission points for the Livermore site and Site 300, of collective EDEs for populations within 80 km of each site, status in reguard to continuous monitoring requirements and periodic confirmatory measurements, improvements in the sampling and monitoring systems and progress on a NESHAPs quality assurance program - is described in this annual report. In April 1994 the EPA notified DOE and LLNL that all requirements of the FFCA had been met, and that LLNL was in compliance with the NESHAPs regulations

2016 annual electricity report

International Nuclear Information System (INIS)

2017-01-01

Generation: Declines in generation were primarily seen with oil-fired, nuclear and coal-fired capacity in 2016. Nuclear power generation decreased due to the closure of several plants to conduct tests requested by French nuclear safety authority ASN starting in November. Nearly 20% of demand was met with generation from renewable sources. In 2016, total electricity generation capacity increased by 1,700 MW (+1.3%), to 130,818 MW, on the back of renewable energy development (+2,200 MW), which more than offset the contraction in thermal generation capacity. Consumption: Annual power consumption stabilised in France for the sixth consecutive year. Increasingly efficient appliances once again contributed to this trend. Markets: France's exchange balance decreased due to the drop in domestic nuclear power generation. Flexibility: RTE made further progress in 2016 toward implementing the capacity mechanism, the first delivery year of which started on 1 January 2017. This mechanism requires that suppliers obtain generation or demand response capacity certificates to show that they are covering their customers' annual consumption during peak demand periods. Network: RTE's investments are a reflection of the significant effort that will be required to meet the challenges of the energy transition over the coming years

Quarterly Progress Report (January 1 to March 31, 1950)

Energy Technology Data Exchange (ETDEWEB)

Brookhaven National Laboratory

1950-04-01

This is the first of a series of Quarterly Reports. These reports will deal primarily with the progress made in our scientific program during a three months period. Those interested in matters pertaining to organization, administration, complete scientific program, personnel and other matters not directly involved in current scientific progress are referred to our Annual Progress Report which is issued in January. We have attempted to describe new information that appears significant, or of interest, to other scientists within the Atomic Energy Commission Laboratories. No effort has been made, however, to detail progress in each and every research project. Little or no reference will therefore be found to the projects in which progress during the current period is considered too inconclusive. Since our organizational structure is departmental, the work described herein is arranged in the following sequence: (1) Accelerator Project; (2) Biology Department; (3) Chemistry Department; (4) Instrumentation and Health Physic8 Department; (5) Medical Department; (6) Physics Department; and (7) Reactor Science and Engineering Department.

Departmental of Clinical Investigation: Annual Research Progress Report for Fiscal Year 1992. Volume 1

Science.gov (United States)

1993-01-01

effect of cisapride on the symptoms of unexplained upper abdominal pain, nausea, vomiting, anorexia, early satiety, bloating/ distension in patients with...for 30 minutes following eccentric exercise will less the 3 indices of delayed-onset muscle soreness (DOMS): perceived muscular soreness, reduced...post-exercise and the Talag Pain Rating Scale will be used to assess muscular soreness. Progress: No progress report was furnished by the principal

Progressive osseous heteroplasia (POH): an Egyptian patient | El ...

African Journals Online (AJOL)

Progressive osseous heteroplasia is a rare genetic disorder characterized by cutaneous ossification during infancy and progressive ossification of subcutaneous and deep connective tissue including muscle and fascia during childhood. It is at the severe end of a spectrum of Guanine Nucleotide-binding protein, ...

Ski protein levels increase during in vitro progression of HPV16-immortalized human keratinocytes and in cervical cancer

International Nuclear Information System (INIS)

Chen, Yi; Pirisi, Lucia; Creek, Kim E.

2013-01-01

We compared the levels of the Ski oncoprotein, an inhibitor of transforming growth factor-beta (TGF-β) signaling, in normal human keratinocytes (HKc), HPV16 immortalized HKc (HKc/HPV16), and differentiation resistant HKc/HPV16 (HKc/DR) in the absence and presence of TGF-β. Steady-state Ski protein levels increased in HKc/HPV16 and even further in HKc/DR, compared to HKc. TGF-β treatment of HKc, HKc/HPV16, and HKc/DR dramatically decreased Ski. TGF-β-induced Ski degradation was delayed in HKc/DR. Ski and phospho-Ski protein levels are cell cycle dependent with maximal Ski expression and localization to centrosomes and mitotic spindles during G2/M. ShRNA knock down of Ski in HKc/DR inhibited cell proliferation. More intense nuclear and cytoplasmic Ski staining and altered Ski localization were found in cervical cancer samples compared to adjacent normal tissue in a cervical cancer tissue array. Overall, these studies demonstrate altered Ski protein levels, degradation and localization in HPV16-transformed human keratinocytes and in cervical cancer. - Highlights: • Ski oncoprotein levels increase during progression of HPV16-transformed cells. • Ski and phospho-Ski protein levels are cell cycle dependent. • Ski knock-down in HPV16-transformed keratinocytes inhibited cell proliferation. • Cervical cancer samples overexpress Ski

Studies of the repair of radiation-induced genetic damage in Drosophila Annual progress report, 1 November 1994 - 1 January 1996

International Nuclear Information System (INIS)

Hawley, R.S.

1996-01-01

The authors have recently cloned the mei-4l gene, and showed that its putative translation product is highly homologous to the ATM, MEC1, and RAD3 genes at the level of primary amino acid sequence. That this sequence similarity reflects a functional homology is suggested by three lines of evidence: (1) as is the case for the ATM gene, loss of function of mei-4l results in increased sensitivity to X-irradiation; (2) mutations in the mei-4l gene also resemble ATM mutations in that they cause high levels of chromosome breakage and genetic instability; and (3) like the ATM gene, the wild-type MEI-4l protein also plays a role in mediating the progression of the cell cycle

An Annual Report to the Legislature on Oregon Public Schools. Oregon Statewide Report Card. 2014-2015

Science.gov (United States)

Oregon Department of Education, 2015

2015-01-01

The Oregon Statewide Report Card is an annual publication required by law (ORS 329.115), which reports on the state of public schools and their progress towards the goals of the Oregon Educational Act for the 21st Century. The purpose of the Oregon Report Card is to monitor trends among school districts and Oregon's progress toward achieving the…

FY2016 Advanced Batteries R&D Annual Progress Report

Energy Technology Data Exchange (ETDEWEB)

None, None

2017-08-31

The Advanced Batteries research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for projects focusing on batteries for plug-in electric vehicles. Program targets focus on overcoming technical barriers to enable market success including: (1) significantly reducing battery cost, (2) increasing battery performance (power, energy, durability), (3) reducing battery weight & volume, and (4) increasing battery tolerance to abusive conditions such as short circuit, overcharge, and crush. This report describes the progress made on the research and development projects funded by the Battery subprogram in 2016. This section covers the Vehicle Technologies Office overview; the Battery subprogram R&D overview; Advanced Battery Development project summaries; and Battery Testing, Analysis, and Design project summaries. It also includes the cover and table of contents.

An annual performance appraisal for CERN

CERN Multimedia

2012-01-01

The March Council session is the occasion for CERN’s annual performance appraisal, but instead of the MARS form familiar to CERN staff, the lab’s working document is an Annual Progress Report, linked to the Medium-Term Plan, matching achievements to objectives. This year, I think it’s fair to say, we were firmly able to tick the ‘achieved’ box.   Top of the list of objectives was the LHC, which exceeded expectations in 2011 by delivering over five times the anticipated luminosity for protons while improving the lead-ion integrated luminosity by an order of magnitude compared to 2010.  As a result, the experiments published over 190 papers and made a staggering 1900 conference presentations. Underpinning this was the Worldwide LHC Computing Grid, which routinely performs so well that we hardly notice it's there. Non-LHC physics also had its day in the sun in 2011, with experiments at the PS, SPS, AD, n_TOF and ISOLDE, as well ...

7th REGENT semi-annual report

International Nuclear Information System (INIS)

Schlechtendahl, E.G.

1975-08-01

The project REGENT (German acronym for CAD, computer aided design) was started early 1972 by the Institut fuer Reaktorentwicklung. The seventh semi-annual progress report summarizes the results achieved up to March 31, 1975, in particular with respect to the development of the REGENT system nucleus and its application for the first REGENT subsystems. The development of the REGENT nucleus and of a graphical subsystem has become a part of the project CAD since mid 1974. Other subsystems are being developed within the framework of the project PNS (Project Nuclear Safety). (orig.) [de

Environmental Sciences Division. Annual progress report for period ending September 30, 1979

International Nuclear Information System (INIS)

1980-03-01

Progress for the period ending September 30, 1979 by the Environmental Sciences Division is reported. Sections reporting include terrestrial ecoloy; earth sciences; environmental resources; aquatic ecology; synthetic fuels; nuclear program; environmental impacts program; ecosystem studies; and burial ground technology

Analytical Chemistry Laboratory progress report for FY 1999

Energy Technology Data Exchange (ETDEWEB)

Green, D. W.; Boparai, A. S.; Bowers, D. L.; Graczyk, D. G.

2000-06-15

This report summarizes the activities of the Analytical Chemistry Laboratory (ACL) at Argonne National Laboratory (ANL) for Fiscal Year (FY) 1999 (October 1998 through September 1999). This annual progress report, which is the sixteenth in this series for the ACL, describes effort on continuing projects, work on new projects, and contributions of the ACL staff to various programs at ANL.

Analytical Chemistry Laboratory progress report for FY 1998.

Energy Technology Data Exchange (ETDEWEB)

Boparai, A. S.; Bowers, D. L.; Graczyk, D. G.; Green, D. W.; Lindahl, P. C.

1999-03-29

This report summarizes the activities of the Analytical Chemistry Laboratory (ACL) at Argonne National Laboratory (ANL) for Fiscal Year (FY) 1998 (October 1997 through September 1998). This annual progress report, which is the fifteenth in this series for the ACL, describes effort on continuing projects, work on new projects, and contributions of the ACL staff to various programs at ANL.

Analytical Chemistry Laboratory progress report for FY 1998

International Nuclear Information System (INIS)

Boparai, A. S.; Bowers, D. L.; Graczyk, D. G.; Green, D. W.; Lindahl, P. C.

1999-01-01

This report summarizes the activities of the Analytical Chemistry Laboratory (ACL) at Argonne National Laboratory (ANL) for Fiscal Year (FY) 1998 (October 1997 through September 1998). This annual progress report, which is the fifteenth in this series for the ACL, describes effort on continuing projects, work on new projects, and contributions of the ACL staff to various programs at ANL

Reporting Florida's Annual Measurable Objectives (AMOs) in Compliance with ESEA Flexibility Requirements: Guide to Calculations for 2013-14

Science.gov (United States)

Florida Department of Education, 2014

2014-01-01

This Annual Measurable Objective (AMO) is designed to keep Florida moving forward toward national and international competitiveness. Florida will compare its National Assessment of Educational Progress (NAEP) scores to those of the top five states and its Trends in International Mathematics and Science Study (TIMSS), Progress in International…

Analytical Chemistry Division annual progress report for period ending December 31, 1983

International Nuclear Information System (INIS)

Lyon, W.S.

1984-05-01

Progress and activities are reported in: analytical methodology, mass and emission spectrometry, radioactive materials analysis, bio/organic analysis, general and environmental analysis, and quality assurance and safety. Supplementary activities are also discussed, and a bibliography of publications is also included

Analytical Chemistry Division annual progress report for period ending December 31, 1983

Energy Technology Data Exchange (ETDEWEB)

Lyon, W.S. (ed.)

1984-05-01

Progress and activities are reported in: analytical methodology, mass and emission spectrometry, radioactive materials analysis, bio/organic analysis, general and environmental analysis, and quality assurance and safety. Supplementary activities are also discussed, and a bibliography of publications is also included. (DLC)

Haptocorrin as marker of disease progression in fibrolamellar hepatocellular carcinoma

DEFF Research Database (Denmark)

Lildballe, Dorte Launholt; Nguyen, Khoa Tran; Poulsen, Steen Seier

2011-01-01

No valid markers are routinely available to follow disease progression in patients with fibrolamellar hepatocellular carcinoma (FLHCC). We report data suggesting that the vitamin B12 binding protein haptocorrin (HC) may prove a suitable marker.......No valid markers are routinely available to follow disease progression in patients with fibrolamellar hepatocellular carcinoma (FLHCC). We report data suggesting that the vitamin B12 binding protein haptocorrin (HC) may prove a suitable marker....

Progress Report 1994; Rapport d`activite 1994

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-12-31

This document is the 1994 annual progress report of the CEA-Direction of Waste Management (DGD). It comprises four chapters. The first chapter is a general presentation of radioactive wastes, of the management of liquid effluents, solid wastes, sealed sources, of the relations with the ANDRA (The French Agency for the Management of Radioactive Wastes), and of the research and development studies in progress for the improvement of waste management. The second chapter concerns the spent fuels and their reprocessing, in particular AGR and PWR type reactor fuels, the ``Caramel`` fuel from Osiris reactor and the cover elements from the Rapsodie reactor core. The long time storage of ancient fuels is also discussed. The third chapter concerns the dismantling of decommissioned installations, the actions in progress and the planning of dismantling actions up to the year 2000. Chapter four is devoted to the management of wastes from the Direction of Military Applications (DAM), the actions in progress in the different DAM centers and the cleansing projects at Marcoule plant. (J.S.). 5 figs., 28 tabs., 21 photos., 3 appendix.

A high protein moderate carbohydrate diet fed at discrete meals reduces early progression of N-methyl-N-nitrosourea-induced breast tumorigenesis in rats

Directory of Open Access Journals (Sweden)

Singletary Keith W

2010-01-01

Full Text Available Abstract Breast cancer is the most prevalent cancer in American women. Dietary factors are thought to have a strong influence on breast cancer incidence. This study utilized a meal-feeding protocol with female Sprague-Dawley rats to evaluate effects of two ratios of carbohydrate:protein on promotion and early progression of breast tissue carcinomas. Mammary tumors were induced by N-methyl-N-nitrosourea (MNU at 52 d of age. Post-induction, animals were assigned to consume either a low protein high carbohydrate diet (LPHC; 15% and 60% of energy, respectively or a high protein moderate carbohydrate diet (HPMC; 35% and 40% of energy, respectively for 10 wk. Animals were fed 3 meals/day to mimic human absorption and metabolism patterns. The rate of palpable tumor incidence was reduced in HPMC relative to LPHC (12.9 ± 1.4%/wk vs. 18.2 ± 1.3%/wk. At 3 wk, post-prandial serum insulin was larger in the LPHC relative to HPMC (+136.4 ± 33.1 pmol/L vs. +38.1 ± 23.4 pmol/L, while at 10 wk there was a trend for post-prandial IGF-I to be increased in HPMC (P = 0.055. There were no differences in tumor latency, tumor surface area, or cumulative tumor mass between diet groups. The present study provides evidence that reducing the dietary carbohydrate:protein ratio attenuates the development of mammary tumors. These findings are consistent with reduced post-prandial insulin release potentially diminishing the proliferative environment required for breast cancer tumors to progress.

Connective tissue growth factor (CTGF) and cancer progression.

Science.gov (United States)

Chu, Chia-Yu; Chang, Cheng-Chi; Prakash, Ekambaranellore; Kuo, Min-Liang

2008-11-01

Connective tissue growth factor (CTGF) is a member of the CCN family of secreted, matrix-associated proteins encoded by immediate early genes that play various roles in angiogenesis and tumor growth. CCN family proteins share uniform modular structure which mediates various cellular functions such as regulation of cell division, chemotaxis, apoptosis, adhesion, motility, angiogenesis, neoplastic transformation, and ion transport. Recently, CTGF expression has been shown to be associated with tumor development and progression. There is growing body of evidence that CTGF may regulate cancer cell migration, invasion, angiogenesis, and anoikis. In this review, we will highlight the influence of CTGF expression on the biological behavior and progression of various cancer cells, as well as its regulation on various types of protein signals and their mechanisms.

Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2.

Science.gov (United States)

Furness, David N; Johnson, Stuart L; Manor, Uri; Rüttiger, Lukas; Tocchetti, Arianna; Offenhauser, Nina; Olt, Jennifer; Goodyear, Richard J; Vijayakumar, Sarath; Dai, Yuhai; Hackney, Carole M; Franz, Christoph; Di Fiore, Pier Paolo; Masetto, Sergio; Jones, Sherri M; Knipper, Marlies; Holley, Matthew C; Richardson, Guy P; Kachar, Bechara; Marcotti, Walter

2013-08-20

Mechanotransduction in the mammalian auditory system depends on mechanosensitive channels in the hair bundles that project from the apical surface of the sensory hair cells. Individual stereocilia within each bundle contain a core of tightly packed actin filaments, whose length is dynamically regulated during development and in the adult. We show that the actin-binding protein epidermal growth factor receptor pathway substrate 8 (Eps8)L2, a member of the Eps8-like protein family, is a newly identified hair bundle protein that is localized at the tips of stereocilia of both cochlear and vestibular hair cells. It has a spatiotemporal expression pattern that complements that of Eps8. In the cochlea, whereas Eps8 is essential for the initial elongation of stereocilia, Eps8L2 is required for their maintenance in adult hair cells. In the absence of both proteins, the ordered staircase structure of the hair bundle in the cochlea decays. In contrast to the early profound hearing loss associated with an absence of Eps8, Eps8L2 null-mutant mice exhibit a late-onset, progressive hearing loss that is directly linked to a gradual deterioration in hair bundle morphology. We conclude that Eps8L2 is required for the long-term maintenance of the staircase structure and mechanosensory function of auditory hair bundles. It complements the developmental role of Eps8 and is a candidate gene for progressive age-related hearing loss.

2016 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

Energy Technology Data Exchange (ETDEWEB)

Satyapal, Sunita [National Renewable Energy Lab. (NREL), Golden, CO (United States)

2017-02-01

In the past year, the DOE Hydrogen Program (the Program) made substantial progress toward its goals and objectives. The Program has conducted comprehensive and focused efforts to enable the widespread commercialization of hydrogen and fuel cell technologies in diverse sectors of the economy. With emphasis on applications that will effectively strengthen our nation's energy security and improve our stewardship of the environment, the Program engages in research, development, and demonstration of critical improvements in the technologies. Highlights of the Program's accomplishments can be found in the sub-program chapters of this report.

2015 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

Energy Technology Data Exchange (ETDEWEB)

Popovich, Neil

2015-12-01

In the past year, the DOE Hydrogen Program (the Program) made substantial progress toward its goals and objectives. The Program has conducted comprehensive and focused efforts to enable the widespread commercialization of hydrogen and fuel cell technologies in diverse sectors of the economy. With emphasis on applications that will effectively strengthen our nation's energy security and improve our stewardship of the environment, the Program engages in research, development, and demonstration of critical improvements in the technologies. Highlights of the Program's accomplishments can be found in the sub-program chapters of this report.

2012 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

Energy Technology Data Exchange (ETDEWEB)

2012-12-01

In the past year, the DOE Hydrogen Program (the Program) made substantial progress toward its goals and objectives. The Program has conducted comprehensive and focused efforts to enable the widespread commercialization of hydrogen and fuel cell technologies in diverse sectors of the economy. With emphasis on applications that will effectively strengthen our nation's energy security and improve our stewardship of the environment, the Program engages in research, development, and demonstration of critical improvements in the technologies. Highlights of the Program's accomplishments can be found in the sub-program chapters of this report.

Department of Clinical Investigation Annual Research Progress Report, Fiscal Year 1984. Volume 1,

Science.gov (United States)

1984-10-01

of Psychiatry Gaupp, P.A. Seizure disorders in children. Fort Worth Child Study Center’s Annual Conference on Neuropsychological Assessment of...study implementation; (2) Eat in order to satisfy hunger ; (3) Agree with 228 C-21-82 (continued) the statement that things go vrong even though no...were: (1) Initial weight at time of study implementation; (2) Eat in order to satisfy hunger ; (3) Usually eat when happy; (4) Usually eat alone; and (5

Subseabed Disposal Program. Annual report, January-December 1978

International Nuclear Information System (INIS)

Talbert, D.M.

1980-02-01

This is the fifth annual report describing the progress and evaluating the status of the Subseabed Disposal Program (SDP), which was begun in June 1973. The program was initiated by Sandia Laboratories to explore the utility of stable, uniform, and relatively unproductive areas of the world as possible repositories for high-level nuclear wastes. The program, now international in scope, is currently focused on the stable submarine geologic formations under the deep oceans

Neutron Physics Laboratory. Annual Progress Report October 1, 1967-September 30, 1968

International Nuclear Information System (INIS)

Wiedling, T.

1969-04-01

The present progress report gives some short descriptions of experiments going on in the neutron physics branch at the Studsvik laboratories. The main program concerns fast neutron physics at the Van de Graaff laboratory with a strong emphasis on neutron scattering cross section data of elements of interest for reactor calculations. Since the Van de Graaff accelerator is still the one in Sweden giving the highest potential, it has been quite natural to use the machine also for some nuclear physics experiments with charged particles, though in some cases related to the neutron physics program. In connection with the use of the reactors at Studsvik for physics experiments, research programs have been in progress for several years concerning the use of reactor neutrons for production of isotopes for a systematic study of short lived nuclear isomeric states as well as for the study of the gamma emission in the fission process

Neutron Physics Laboratory. Annual Progress Report October 1, 1967-September 30, 1968

Energy Technology Data Exchange (ETDEWEB)

Wiedling, T

1969-04-15

The present progress report gives some short descriptions of experiments going on in the neutron physics branch at the Studsvik laboratories. The main program concerns fast neutron physics at the Van de Graaff laboratory with a strong emphasis on neutron scattering cross section data of elements of interest for reactor calculations. Since the Van de Graaff accelerator is still the one in Sweden giving the highest potential, it has been quite natural to use the machine also for some nuclear physics experiments with charged particles, though in some cases related to the neutron physics program. In connection with the use of the reactors at Studsvik for physics experiments, research programs have been in progress for several years concerning the use of reactor neutrons for production of isotopes for a systematic study of short lived nuclear isomeric states as well as for the study of the gamma emission in the fission process.

Hungry Horse Mitigation : Flathead Lake : Annual Progress Report 2008.

Energy Technology Data Exchange (ETDEWEB)

Hansen, Barry; Evarts, Les [Confederated Salish and Kootenai Tribes

2009-08-06

. Monitoring, for example, includes a spring gillnetting series conducted annually in Flathead Lake and builds on an existing data set initiated in 1981. Monitoring of the experimental kokanee reintroduction was a primary activity of this project between 1992 and 1997. Lake trout, whose high densities have precluded successful mitigation of losses of other species in Flathead Lake, have been monitored since 1996 to measure several biological parameters. Results of this work have utility in determining the population status of this key predator in Flathead Lake. The project has also defined the baseline condition of the Flathead Lake fishery in 1992-1993 and has conducted annual lakewide surveys since 1998. The restoration component of the project has addressed several stream channel, riparian, and fish passage problems, and suppression of non-native fish. The research component of the project began in FY 2000 and measured trophic linkages between M. relicta and other species to assist in predicting the results of our efforts to suppress lake trout. Only Work Element A in the Statement of Work is funded entirely by Hungry Horse Mitigation funds. Additional funds are drawn from other sources to assist in completion of all remaining Work Elements.

Hungry Horse Mitigation : Flathead Lake : Annual Progress Report 2007.

Energy Technology Data Exchange (ETDEWEB)

Hansen, Barry; Evarts, Les [Confederated Salish and Kootenai Tribes

2008-12-22

. Monitoring, for example, includes a spring gillnetting series conducted annually in Flathead Lake and builds on an existing data set initiated in 1981. Monitoring of the experimental kokanee reintroduction was a primary activity of this project between 1992 and 1997. Lake trout, whose high densities have precluded successful mitigation of losses of other species in Flathead Lake, have been monitored since 1996 to measure several biological parameters. Results of this work have utility in determining the population status of this key predator in Flathead Lake. The project has also defined the baseline condition of the Flathead Lake fishery in 1992-1993 and has conducted annual lakewide surveys since 1998. The restoration component of the project has addressed several stream channel, riparian, and fish passage problems, and suppression of non-native fish. The research component of the project began in FY 2000 and measured trophic linkages between M. relicta and other species to assist in predicting the results of our efforts to suppress lake trout. Only Work Element A in the Statement of Work is funded entirely by Hungry Horse Mitigation funds. Additional funds are drawn from other sources to assist in completion of all remaining Work Elements.

Natural proteasome inhibitor celastrol suppresses androgen-independent prostate cancer progression by modulating apoptotic proteins and NF-kappaB.

Directory of Open Access Journals (Sweden)

Yao Dai

Full Text Available Celastrol is a natural proteasome inhibitor that exhibits promising anti-tumor effects in human malignancies, especially the androgen-independent prostate cancer (AIPC with constitutive NF-κB activation. Celastrol induces apoptosis by means of proteasome inhibition and suppresses prostate tumor growth. However, the detailed mechanism of action remains elusive. In the current study, we aim to test the hypothesis that celastrol suppresses AIPC progression via inhibiting the constitutive NF-κB activity as well as modulating the Bcl-2 family proteins.We examined the efficacy of celastrol both in vitro and in vivo, and evaluated the role of NF-κB in celastrol-mediated AIPC regression. We found that celastrol inhibited cell proliferation in all three AIPC cell lines (PC-3, DU145 and CL1, with IC₅₀ in the range of 1-2 µM. Celastrol also suppressed cell migration and invasion. Celastrol significantly induced apoptosis as evidenced by increased sub-G1 population, caspase activation and PARP cleavage. Moreover, celastrol promoted cleavage of the anti-apoptotic protein Mcl-1 and activated the pro-apoptotic protein Noxa. In addition, celastrol rapidly blocked cytosolic IκBα degradation and nuclear translocation of RelA. Likewise, celastrol inhibited the expression of multiple NF-κB target genes that are involved in proliferation, invasion and anti-apoptosis. Celastrol suppressed AIPC tumor progression by inhibiting proliferation, increasing apoptosis and decreasing angiogenesis, in PC-3 xenograft model in nude mouse. Furthermore, increased cellular IκBα and inhibited expression of various NF-κB target genes were observed in tumor tissues.Our data suggest that, via targeting the proteasome, celastrol suppresses proliferation, invasion and angiogenesis by inducing the apoptotic machinery and attenuating constitutive NF-κB activity in AIPC both in vitro and in vivo. Celastrol as an active ingredient of traditional herbal medicine could thus be

FY 1999 Annual Self-Evaluation Report of the Pacific Northwest National Laboratory

Energy Technology Data Exchange (ETDEWEB)

Randy R. LaBarge

1999-11-05

This is a report of the Pacific Northwest National Laboratory's (Pacific Northwest's) FY1999 Annual Self-Evaluation Report. This report summarizes our progress toward accomplishment of the critical outcomes, objectives, and performance indicators as delineated in the FY1999 Performance Evaluation & Fee Agreement. It also summarizes our analysis of the results of Pacific Northwest's Division and Directorate annual self-assessments, and the implementation of our key operational improvement initiatives. Together, these provide an indication of how well we have used our Integrated Assessment processes to identify and plan improvements for FY2000. As you review the report you will find areas of significantly positive progress; you will also note areas where I believe the Laboratory could make improvements. Overall, however, I believe you will be quite pleased to note that we have maintained, or exceeded, the high standards of performance we have set for the Laboratory.

LLE 2010 Annual Report October 2009 - September 2010

Energy Technology Data Exchange (ETDEWEB)

None

2011-01-01

The fiscal year ending September 2010 (FY10) concluded the third year of the third five-year renewal of Cooperative Agreement DE-FC52-08NA28302 with the U.S. Department of Energy (DOE). This annual report summarizes progress in inertial fusion research at the Laboratory for Laser Energetics (LLE) during the past fiscal year including work on the National Ignition Campaign (NIC). It also reports on LLE's progress on laboratory basic science research; laser, optical materials, and advanced technology development; operation of OMEGA and OMEGA EP for the NIC and high-energy density (HED) campaigns, the National Laser Users Facility (NLUF), and for other external users; and programs focusing on the education of high school, undergraduate, and graduate students during the year.

Analytical Chemistry Division annual progress report for period ending December 31, 1984

International Nuclear Information System (INIS)

Lyon, W.S.

1985-04-01

Progress reports are presented for the following sections: analytical methodology; mass and emission spectroscopy; radioactive materials analysis; bio/organic analysis; and general and environmental analysis; quality assurance, safety, and tabulation analyses. In addition a list of publications and oral presentations and supplemental activities are included

Analytical Chemistry Division annual progress report for period ending December 31, 1984

Energy Technology Data Exchange (ETDEWEB)

Lyon, W.S. (ed.)

1985-04-01

Progress reports are presented for the following sections: analytical methodology; mass and emission spectroscopy; radioactive materials analysis; bio/organic analysis; and general and environmental analysis; quality assurance, safety, and tabulation analyses. In addition a list of publications and oral presentations and supplemental activities are included.

Generation 4 International Forum. 2008 annual report

International Nuclear Information System (INIS)

2008-01-01

This 2008 Annual Report is the second annual report issued by GIF (Generation IV International Forum). It provides an update on the GIF organization, membership, and participation in research and development (R-D) projects for each Generation IV system. It summarizes the milestones for development of each system and progress of the R-D toward their accomplishment. Finally, it includes a brief description of the cooperation between GIF and other international endeavors for the development of nuclear energy. Chapter 2 describes the membership and organization of the GIF, the structure of its cooperative research and development arrangements, and the status of Member participation in those arrangements. Chapter 3 provides a summary of the GIF R-D plans, and its activities and achievements during 2008. It highlights the R-D challenges facing the teams developing Generation IV systems and the major milestones towards the development of these systems. It also describes the progress made regarding the development of methodologies for assessing Generation IV systems with respect to the established goals of GIF. Chapter 4 reviews other major international collaborative projects in the field of nuclear energy and explains how the GIF interacts and cooperates with them. Appendix 1 provides an overview on the goals of Generation IV nuclear energy systems and outlines the main characteristics of the six systems selected for joint development by GIF. The list of abbreviations and acronyms given at the end of the report defines terms used in the various chapters including various nuclear energy systems and international programs referred to in connection with GIF R-D activities. Some bibliographical references are given in order to facilitate access to public information about R-D progress and achievements on specific technical issues for GIF systems

International VLBI Service for Geodesy and Astrometry 2000 Annual Report

Science.gov (United States)

Vandenberg, N. R. (Editor); Baver, K. D. (Editor); Smith, David E. (Technical Monitor)

2000-01-01

This volume of reports is the 2000 Annual Report of the International Very Long Base Interferometry (VLBI) Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the permanent components of IVS. The IVS 2000 Annual Report documents the work of the IVS components for the period March 1, 1999 (the official inauguration date of IVS) through December 31, 2000. The reports document changes, activities, and progress of the IVS. The entire contents of this Annual Report also appear on the IVS web site at http://ivscc.gsfc.nasa.gov/publications/ar2000. This book and the web site are organized as follows: (1) The first section contains general information about IVS, a map showing the location of the components, information about the Directing Board members, and the report of the IVS Chair; (2) The second section of Special Reports contains a status report of the IVS Working Group on GPS phase center mapping, a reproduction of the resolution making IVS a Service of the International Astronomical Union (IAU), and a reprint of the VLBI Standard Interface (VSI); (3) The next seven sections hold the component reports from the Coordinators, Network Stations, Operation Centers, Correlators, Data Centers, Analysis Centers, and Technology Development Centers; and (4) The last section includes reference information about IVS: the Terms of Reference, the lists of Member and Affiliated organizations, the IVS Associate Member list, a complete list of IVS components, the list of institutions contributing to this report, and a list of acronyms. The 2000 Annual Report demonstrates the vitality of the IVS and the outstanding progress we have made during our first 22 months.

Workplace Charging Challenge Progress Update 2016: A New Sustainable Commute

Energy Technology Data Exchange (ETDEWEB)

None, None

2017-01-31

In the 2016 Workplace Charging Challenge annual survey, partners shared for the how their efforts were making an impact in their communities and helped identify best practices for workplace charging. The Workplace Charging Challenge Progress Update highlights the findings from this survey and recognizes leading employers for their workplace charging efforts.

Energy Division annual progress report for period ending September 30, 1981

Energy Technology Data Exchange (ETDEWEB)

1982-05-01

This eighth annual report of the Division covers work done during FY 1981 (October 1, 1980, through September 30, 1981). As with these documents in the past, the format follows approximately the organizational structure of the Energy Division. Chapters 2 through 6 summarize the activities of the sections of the Division: Environmental Impact Section, headed by H.E. Zittel; Regional and Urban Studies Section, R.M. Davis; Economic Analysis Section, R.B. Shelton; Data and Analysis Section, A.S. Loebl; and Efficiency and Renewables Research Section, J.W. Michel. In addition, work on a variety of projects which cut across section lines is reported in Chapter 7, Integrated Programs. These activities are under the supervision of T.J. Wilbanks, Associate Director for the Division. Separate abstracts are included for individual projects.

Energy Division annual progress report for period ending September 30, 1981

International Nuclear Information System (INIS)

1982-05-01

This eighth annual report of the Division covers work done during FY 1981 (October 1, 1980, through September 30, 1981). As with these documents in the past, the format follows approximately the organizational structure of the Energy Division. Chapters 2 through 6 summarize the activities of the sections of the Division: Environmental Impact Section, headed by H.E. Zittel; Regional and Urban Studies Section, R.M. Davis; Economic Analysis Section, R.B. Shelton; Data and Analysis Section, A.S. Loebl; and Efficiency and Renewables Research Section, J.W. Michel. In addition, work on a variety of projects which cut across section lines is reported in Chapter 7, Integrated Programs. These activities are under the supervision of T.J. Wilbanks, Associate Director for the Division. Separate abstracts are included for individual projects

Recent progress in Biophysics

International Nuclear Information System (INIS)

Bemski, G.

1980-03-01

Recent progress in biophysics is reviewed, and three examples of the use of physical techniques and ideas in biological research are given. The first one deals with the oxygen transporting protein-hemoglobin, the second one with photosynthesis, and the third one with image formation, using nuclear magnetic resonance. (Author) [pt

Annual Continuation And Progress Report For Nuclear Theory At Lawrence Livermore National Laboratory

Energy Technology Data Exchange (ETDEWEB)

Ormand, W. E. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Quaglioni, S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Schunck, N. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Vogt, R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Vranas, P. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2015-10-26

Nuclear Theory research under the auspices of the Department of Energy (DOE) Office of Nuclear Physics (NP) is conducted within several funding sources and projects. These include base funding, and early career award, and a collaborative SciDAC-­3 award that is jointly funded by DOE/NP and the Advanced Simulations and Computations (ASC) effort within the National Nuclear Security Agency (NNSA). Therefore, this annual report is organized within the three primary sections covering these projects.

Laser Program annual report 1984

International Nuclear Information System (INIS)

Rufer, M.L.; Murphy, P.W.

1985-06-01

The Laser Program Annual Report is part of the continuing series of reports documenting the progress of the unclassified Laser Fusion Program at the Lawrence Livermore National Laboratory (LLNL). As in previous years, the report is organized programmatically. The first section is an overview of the basic goals and directions of the LLNL Inertial Confinement Fusion (ICF) Program, and highlights the year's important accomplishments. Sections 2 through 7 provide the detailed information on the various program elements: Laser Systems and Operations, Target Design, Target Fabrication, Laser Experiments and Advanced Diagnostics, Advanced Laser Development, and Applications of Inertial Confinement Fusion. Individual sections will be indexed separately. 589 refs., 333 figs., 25 tabs

NRPB annual report 1989-1990

International Nuclear Information System (INIS)

1990-01-01

This annual report outlines technical services available (advisory services, personal monitoring, training) environmental research, including radon in homes studies, release consequences to the environment, accidents and emergency plans. In the biomedical sciences work is in progress to prepare the National Registry for Radiation Workers, studies are being made on patient protection in diagnostic radiology, age-dependent dosimetry, gut absorption, fetal dosimetry, inhalation studies, particularly of plutonium, biological dosimetry based on chromosomal aberrations, cancer risks. The Physical Sciences section has been looking at non-ionising radiation risks, development of an electronic personal dosemeter, the safety review of Oldbury power station, and occupational exposure to radon. (author)

Energy Storage Annual Progress Report for FY15

Energy Technology Data Exchange (ETDEWEB)

Pesaran, Ahmad [National Renewable Energy Lab. (NREL), Golden, CO (United States); Ban, Chunmei [National Renewable Energy Lab. (NREL), Golden, CO (United States); Cao, Lei [National Renewable Energy Lab. (NREL), Golden, CO (United States); Graf, Peter [National Renewable Energy Lab. (NREL), Golden, CO (United States); Keyser, Matt [National Renewable Energy Lab. (NREL), Golden, CO (United States); Kim, Gi-Heon [National Renewable Energy Lab. (NREL), Golden, CO (United States); Santhanagopalan, Shriram [National Renewable Energy Lab. (NREL), Golden, CO (United States); Saxon, Aron [National Renewable Energy Lab. (NREL), Golden, CO (United States); Shi, Ying [National Renewable Energy Lab. (NREL), Golden, CO (United States); Smith, Kandler [National Renewable Energy Lab. (NREL), Golden, CO (United States); Tenent, Robert [National Renewable Energy Lab. (NREL), Golden, CO (United States); Yang, Chuanbo [National Renewable Energy Lab. (NREL), Golden, CO (United States); Zhang, Chao [National Renewable Energy Lab. (NREL), Golden, CO (United States)

2016-12-01

The Energy Storage research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for projects focusing on batteries for plug-in electric vehicles (PEVs) in support of the EV Everywhere Grand Challenge. PEVs could have a significant impact on the nation's goal of reducing dependence on imported oil and gaseous pollutant emissions. The Energy Storage program targets overcoming technical barriers to enable market success, including: (1) significantly reducing battery cost; (2) increasing battery performance (power, energy, durability); (3) reducing battery weight and volume; and (4) increasing battery tolerance to abusive conditions such as short circuit, overcharge, and crush. The National Renewable Energy Laboratory (NREL) supports the VTO's Energy Storage program by evaluating the thermal performance of cells and packs, developing electrochemical-thermal models to accelerate the design cycle for developing batteries, investigating the behavior of lithium-ion batteries under abuse conditions such as crush, enhancing the durability of electrodes by coatings such as atomic layer deposition, synthesis of materials for higher energy density batteries, and conducting techno-economic analysis of batteries in various electric-drive vehicles. This report describes the progress made by NREL on the research and development projects funded by the DOE VTO Energy Storage subprogram in FY15.

Analytical chemistry laboratory. Progress report for FY 1997

Energy Technology Data Exchange (ETDEWEB)

Green, D.W.; Boparai, A.S.; Bowers, D.L. [and others

1997-12-01

The purpose of this report is to summarize the activities of the Analytical Chemistry Laboratory (ACL) at Argonne National Laboratory (ANL) for Fiscal Year (FY) 1997 (October 1996 through September 1997). This annual progress report is the fourteenth in this series for the ACL, and it describes continuing effort on projects, work on new projects, and contributions of the ACL staff to various programs at ANL.

Nevada Test Site Resource Management Plan: Annual summary, January 2000

International Nuclear Information System (INIS)

2000-01-01

The Nevada Test Site Resource Management Plan published in December of 1998 (DOE/NV--518) describes the Nevada Test Site stewardship mission and how its accomplishment will preserve the resources of the ecoregion while accomplishing the objectives of the mission. As part of the Nevada Test Site Resource Management Plan, DOE Nevada Operations Office has committed to perform and publish an annual summary review of DOE Nevada Operations' stewardship of the Nevada Test Site. This annual summary includes a description of progress made toward the goals of the Nevada Test Site Resource Management Plan, pertinent monitoring data, actions that were taken to adapt to changing conditions, and any other changes to the Nevada Test Site Resource Management Plan

Nevada Test Site Resource Management Plan: Annual summary, January 2000

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-01-01

The Nevada Test Site Resource Management Plan published in December of 1998 (DOE/NV--518) describes the Nevada Test Site stewardship mission and how its accomplishment will preserve the resources of the ecoregion while accomplishing the objectives of the mission. As part of the Nevada Test Site Resource Management Plan, DOE Nevada Operations Office has committed to perform and publish an annual summary review of DOE Nevada Operations' stewardship of the Nevada Test Site. This annual summary includes a description of progress made toward the goals of the Nevada Test Site Resource Management Plan, pertinent monitoring data, actions that were taken to adapt to changing conditions, and any other changes to the Nevada Test Site Resource Management Plan.

Association of adiponectin, interleukin (IL)-1ra, inducible protein 10, IL-6 and number of islet autoantibodies with progression patterns of type 1 diabetes the first year after diagnosis

DEFF Research Database (Denmark)

Kaas, A; Pfleger, Claudia Christina; Hansen, Lene

2010-01-01

progressers and remitters. Serum concentrations of adiponectin, interleukin (IL)-1ra, inducible protein 10 (IP-10), IL-6 and glutamic acid decarboxylase (GAD), IA-2A and islet-cell antibodies (ICA) were measured at 1, 6 and 12 months. We found that adiponectin concentrations at 1 month predicted disease......The progression of type 1 diabetes after diagnosis is poorly understood. Our aim was to assess the relation of disease progression of juvenile-onset type 1 diabetes, determined by preserved beta cell function the first year after diagnosis, with systemic cytokine concentrations and number...

The Y-Box Binding Protein 1 Suppresses Alzheimer's Disease Progression in Two Animal Models.

Directory of Open Access Journals (Sweden)

N V Bobkova

Full Text Available The Y-box binding protein 1 (YB-1 is a member of the family of DNA- and RNA binding proteins. It is involved in a wide variety of DNA/RNA-dependent events including cell proliferation and differentiation, stress response, and malignant cell transformation. Previously, YB-1 was detected in neurons of the neocortex and hippocampus, but its precise role in the brain remains undefined. Here we show that subchronic intranasal injections of recombinant YB-1, as well as its fragment YB-11-219, suppress impairment of spatial memory in olfactory bulbectomized (OBX mice with Alzheimer's type degeneration and improve learning in transgenic 5XFAD mice used as a model of cerebral amyloidosis. YB-1-treated OBX and 5XFAD mice showed a decreased level of brain β-amyloid. In OBX animals, an improved morphological state of neurons was revealed in the neocortex and hippocampus; in 5XFAD mice, a delay in amyloid plaque progression was observed. Intranasally administered YB-1 penetrated into the brain and could enter neurons. In vitro co-incubation of YB-1 with monomeric β-amyloid (1-42 inhibited formation of β-amyloid fibrils, as confirmed by electron microscopy. This suggests that YB-1 interaction with β-amyloid prevents formation of filaments that are responsible for neurotoxicity and neuronal death. Our data are the first evidence for a potential therapeutic benefit of YB-1 for treatment of Alzheimer's disease.

Annual report of waste generation and pollution prevention progress 1997

International Nuclear Information System (INIS)

1998-09-01

This sixth Annual Report presents and analyzes DOE Complex-wide waste generation and pollution prevention activities at 36 reporting sites from 1993 through 1997. In May 1996, the Secretary of Energy established a 50 percent Complex-Wide Waste Reduction Goal (relative to the 1993 baseline) for routine operations radioactive and hazardous waste generation, to be achieved by December 31, 1999. Excluding sanitary waste, routine operations waste generation increased three percent from 1996 to 1997, and decreased 61 percent overall from 1993 to 1997. DOE has achieved its Complex-Wide Waste Reduction Goals for routine operations based upon a comparison of 1997 waste generation to the 1993 baseline. However, it is important to note that increases in low-level radioactive and low-level mixed waste generation could reverse this achievement. From 1996 to 1997, low-level radioactive waste generation increased 10 percent, and low-level mixed waste generation increased slightly. It is critical that DOE sites continue to reduce routine operations waste generation for all waste types, to ensure that DOE's Complex-Wide Waste Reduction Goals are achieved by December 31, 1999

Albania; Poverty Reduction Strategy Paper Progress Report

OpenAIRE

International Monetary Fund

2003-01-01

This paper examines the Progress Report for Albania’s National Strategy for Socio-Economic Development (NSSED). 2002 was the first year of implementing the NSSED. The implementation process has been oriented toward achieving the annual objectives and in accordance with the program of public priority measures for 2002–04. The experience gained in NSSED implementation, the definition and improvements to objectives and medium-term NSSED measures, the Millennium Development Goals, and Albania’s E...

Early Involvement of Death-Associated Protein Kinase Promoter Hypermethylation in the Carcinogenesis of Barrett's Esophageal Adenocarcinoma and Its Association with Clinical Progression

Directory of Open Access Journals (Sweden)

Doerthe Kuester

2007-03-01

Full Text Available Esophageal Barrett's adenocarcinoma (BA develops through a multistage process, which is associated with the transcriptional silencing of tumor-suppressor genes by promoter CpG island hypermethylation. In this study, we explored the promoter hypermethylation and protein expression of proapoptotic deathassociated protein kinase (DAPK during the multistep Barrett's carcinogenesis cascade. Early BA and paired samples of premalignant lesions of 61 patients were analyzed by methylation-specific polymerase chain reaction and immunohistochemistry. For the association of clinicopathological markers and protein expression, an immunohistochemical tissue microarray analysis of 66 additional BAs of advanced tumor stages was performed. Hypermethylation of DAPK promoter was detected in 20% of normal mucosa, 50% of Barrett's metaplasia, 53% of dysplasia, and 60% of adenocarcinomas, and resulted in a marked decrease in DAPK protein expression (P < .01. The loss of DAPK protein was significantly associated with advanced depth of tumor invasion and advanced tumor stages (P < .001. Moreover, the severity of reflux esophagitis correlated significantly with the hypermethylation rate of the DAPK promoter (P < .003. Thus, we consider DAPK inactivation by promoter hypermethylation as an early event in Barrett's carcinogenesis and suggest that a decreased protein expression of DAPK likely plays a role in the development and progression of BA.

Annual report 1982-1983

International Nuclear Information System (INIS)

1983-01-01

Since the publication of the 1981 annual report by the Iraqi Atomic Energy Commission (IAEC) significant progress has been made in various areas of the peaceful applications of atomic energy in Iraq. One of the major activities of the IAEC is the medical utilization of radioisotopes which include therapeutic applications in the fields of radiotherapy and oncology, diagnostic applications in nuclear medicine and other uses in medical research. At present, there are four nuclear medicine centres in Iraq. The largest two are situated in Baghdad and the other two are located in the southern and northern parts of the country. The major activities of these centres are reflected in this report. Other major activities of the IAEC are represented by the Nuclear Research Centre (NRC). The NRC is concerned mainly with research on various applications of radioisotopes in agriculture, biology, chemistry, physics and health physics. The present annual report contains extended abstracts of research projects performed at the NRC during the years 1982-1983. The IAEC's endeavour to extend the peaceful applications of atomic energy in Iraq has been going on despite the Israeli act on 7th June, 1981 which destroyed the Tammuz research reactor. In this report, documents issued by international organizations condemning this action are included

ORNL nuclear waste programs annual progress report for period ending September 30, 1982

International Nuclear Information System (INIS)

1983-05-01

Research progress is reported in 20 activities under the headings: spent fuels, defense waste management, commercial waste management, remedial action, and conventional reactors. Separate entries were prepared for each activity

CEA - Annual report 2006

International Nuclear Information System (INIS)

2006-01-01

The CEA, a prominent player in research development and innovation, is active in 3 main areas: energy, health care and information technology and defense and security. This annual report presents the CEA activity for the year 2006 in these three main areas: Science and technology working for nuclear deterrence and global security (the simulation programs, the nuclear warheads, the nuclear propulsion, the decommissioning, the fighting against nuclear proliferation and monitoring international treaties, the global security); health and information technology (micro and nano technologies and systems); energy from nuclear fission and fusion and other technologies that do not emit greenhouse gases (progress for the nuclear industry, sustainable management of radioactive materials and waste, nuclear systems of the future, new energy technologies). (A.L.B.)

Annual report on reactor safety research projects sponsored by the Ministry for Research and Technology of the Federal Republic of Germany 1988

International Nuclear Information System (INIS)

1989-06-01

The GRS (Society for Reactor Safety), Gesellschaft fuer Reaktorsicherheit mbH, by order of the BMFT, informs continuously of the status of such investigations by means of semi-annual and annual publication of progress reports within the series GRS-F-Fortschrittsberichte (GRS-F-Progress Reports). Each progress report represents a compilation of individual reports about objectives, the work performed, the results, the next steps of the work etc. The individual reports are prepared in a standard form by the contractors themselves as a documentation of their progress in work and published by the FB (Research Coordination Department) Forschungsbetreuung at the GRS, within the framework of general information of progress in the reactor safety research. The individual reports are classified according to the same classification system as applied in the nuclear index of the CEC (Commission of the European Communities) and the OECD (Organization for Economic Cooperation and Development). The reports are arranged in sequence of their project numbers. Besides the progress reports, lists of reports exchanged under international exchange agreements by the BMFT are published within this series. (orig./HP)

Pterostilbene acts through metastasis-associated protein 1 to inhibit tumor growth, progression and metastasis in prostate cancer.

Directory of Open Access Journals (Sweden)

Kun Li

Full Text Available The development of natural product agents with targeted strategies holds promise for enhanced anticancer therapy with reduced drug-associated side effects. Resveratrol found in red wine, has anticancer activity in various tumor types. We reported earlier on a new molecular target of resveratrol, the metastasis-associated protein 1 (MTA1, which is a part of nucleosome remodeling and deacetylation (NuRD co-repressor complex that mediates gene silencing. We identified resveratrol as a regulator of MTA1/NuRD complex and re-activator of p53 acetylation in prostate cancer (PCa. In the current study, we addressed whether resveratrol analogues also possess the ability to inhibit MTA1 and to reverse p53 deacetylation. We demonstrated that pterostilbene (PTER, found in blueberries, had greater increase in MTA1-mediated p53 acetylation, confirming superior potency over resveratrol as dietary epigenetic agent. In orthotopic PCa xenografts, resveratrol and PTER significantly inhibited tumor growth, progression, local invasion and spontaneous metastasis. Furthermore, MTA1-knockdown sensitized cells to these agents resulting in additional reduction of tumor progression and metastasis. The reduction was dependent on MTA1 signaling showing increased p53 acetylation, higher apoptotic index and less angiogenesis in vivo in all xenografts treated with the compounds, and particularly with PTER. Altogether, our results indicate MTA1 as a major contributor in prostate tumor malignant progression, and support the use of strategies targeting MTA1. Our strong pre-clinical data indicate PTER as a potent, selective and pharmacologically safe natural product that may be tested in advanced PCa.

Pellets for fusion reactor refueling. Annual progress report, January 31, 1977--January 31, 1978

Energy Technology Data Exchange (ETDEWEB)

None

1978-01-01

Progress during the past year has occurred in the following areas. A pellet generator for larger pellets is currently under construction. Alternate pellet generation techniques are under investigation. Progress has been made on the pellet selection and acceleration scheme for the large pellet generator. Work has begun on ablation acceleration for accelerating pellets to very high velocities. In the area of pellet-plasma interactions work has been completed on a transonic flow model and papers have been published dealing with both experimental and theoretical aspects of the problem.

Pellets for fusion reactor refueling. Annual progress report, January 31, 1977--January 31, 1978

International Nuclear Information System (INIS)

1978-01-01

Progress during the past year has occurred in the following areas. A pellet generator for larger pellets is currently under construction. Alternate pellet generation techniques are under investigation. Progress has been made on the pellet selection and acceleration scheme for the large pellet generator. Work has begun on ablation acceleration for accelerating pellets to very high velocities. In the area of pellet-plasma interactions work has been completed on a transonic flow model and papers have been published dealing with both experimental and theoretical aspects of the problem

Radiation physics and biology: Progress report for period December 1, 1986-November 30, 1987

International Nuclear Information System (INIS)

Rubin, J.S.

1987-04-01

This annual report describes progress made on 14 individual research projects. These projects fall naturally into theoretical biophysics, experimental microdosimetry and radiation biology. Each project has been separately abstracted for the Energy Data Base

A panel of prognostic protein markers for progression in non-muscle invasive bladder cancer - a multicenter tissue microarray validation study

DEFF Research Database (Denmark)

Fristrup, Niels; Birkenkamp-Demtröder, Karin; Ulhøi, Benedicte Parm

2012-01-01

cohort of 283 patients with long-term follow-up. For validation of the results we used three independent patient cohorts with long-term follow-up from Sweden, Spain, and Taiwan. In total 649 primary NMIBC tissue-microarray specimens from patients with long-term follow-up were used. Protein expression......Bladder cancer is the fifth most common cancer in the Western world. The histopathological parameters used in the clinic cannot precisely predict the individual disease course. Bladder cancer patients are therefore monitored thoroughly for disease recurrence and progression by urine and cystoscopy...... Ta and T1 urothelial carcinomas. Transcripts from the five genes encoding these proteins were previously included in gene expression signatures for outcome prediction for non-muscle invasive bladder cancer (NMIBC). As a training-set, we used primary NMIBC tissue-microarray specimens from a Danish...

Expression of RIZ1 protein (Retinoblastoma-interacting zinc-finger protein 1) in prostate cancer epithelial cells changes with cancer grade progression and is modulated in vitro by DHT and E2.

Science.gov (United States)

Rossi, Valentina; Staibano, Stefania; Abbondanza, Ciro; Pasquali, Daniela; De Rosa, Caterina; Mascolo, Massimo; Bellastella, Giuseppe; Visconti, Daniela; De Bellis, Annamaria; Moncharmont, Bruno; De Rosa, Gaetano; Puca, Giovanni Alfredo; Bellastella, Antonio; Sinisi, Antonio Agostino

2009-12-01

The nuclear protein methyl-transferase Retinoblastoma-interacting zinc-finger protein 1 (RIZ1) is considered to be a downstream effector of estrogen action in target tissues. Silencing of RIZ1 expression is common in many tumors. We analyzed RIZ1 expression in normal and malignant prostate tissue and evaluated whether estradiol (E2) or dihydrotestosterone (DHT) treatment modulated RIZ1 in cultured prostate epithelial cells (PEC). Moreover, we studied the possible involvement of RIZ1 in estrogen action on the EPN prostate cell line, constitutively expressing both estrogen receptor (ER)-alpha and beta. RIZ1 protein, found in the nucleus of normal PECs by immunohistochemistry, was progressively lost in cancer tissues as the Gleason score increased and was only detected in the cytoplasmic compartment. RIZ1 transcript levels, as assayed by semi-quantitative RT-PCR in primary PEC cultures, were significantly reduced in cancer cells (P DHT treatment significantly increased RIZ1 transcript and protein levels (P DHT or E2 treatment in vitro. Furthermore, the E2 effects on ER-expressing prostate cells involve RIZ1, which confirms a possible role for ER-mediated pathways in a non-classic E(2)-target tissue.

Annual Research Progress Report. 1 October 1977-30 September 1978.

Science.gov (United States)

1978-09-30

Role of Energy in Nitrogen Balance; 2) Hypocalor - ic Protein Diets ; 3) Nutrition in the Trauma Patient. Postgraduate 25 . . 3 Course in Hospital... Diets . International Conference on Parenteral Nutrition, Bermuda 16 May 77. Pruitt BA Jr: Report of National Representative to International Society...Blood Flow Changes Following Thermal Injury McDougal WS: Influence of Diet on Hepatic Function Lescher TJ: Treatment of Burns. Officers Basic Course

Kootenai River fisheries investigations: rainbow and bull trout recruitment: annual progress report 1999; ANNUAL

International Nuclear Information System (INIS)

Walters, Jody P.; Downs, Christopher Charles

2001-01-01

Our 1999 objectives were to determine sources of rainbow trout Oncorhynchus mykiss and bull trout Salvelinus confluentus spawning and recruitment in the Idaho reach of the Kootenai River. We used a rotary-screw trap to capture juvenile trout to determine age at out-migration and to estimate total out-migration from the Boundary Creek drainage to the Kootenai River. The out-migrant estimate for March through August 1999 was 1,574 (95% C. I.= 825-3,283) juvenile rainbow trout. Most juveniles out-migrated at age-2 and age-3. No out-migrating bull trout were caught. Five of 17 rainbow trout radio-tagged in Idaho migrated upstream into Montana waters during the spawning season. Five bull trout originally radio-tagged in O'Brien Creek, Montana in early October moved downstream into Idaho and British Columbia by mid-October. Annual angler exploitation for the rainbow trout population upstream of Bonners Ferry, Idaho was estimated to be 58%. Multi-pass depletion estimates for index reaches of Caboose, Curley, and Debt creeks showed 0.20, 0.01, and 0.13 rainbow trout juveniles/m(sup 2), respectively. We estimated rainbow trout (180-415 mm TL) standing stock of 1.6 kg/ha for the Hemlock Bar reach (29.4 ha) of the Kootenai River, similar to the 1998 estimate. Recruitment of juvenile rainbow and bull trout from Idaho tributaries is not sufficient to be the sole source of subsequent older fish in the mainstem Kootenai River. These populations are at least partly dependent on recruitment from Montana waters. The low recruitment and high exploitation rate may be indicators of a rainbow trout population in danger of further decline

Annual report 2009. Institute of Radiochemistry

International Nuclear Information System (INIS)

Bernhard, G.

2010-01-01

The annual report 2009 of the institute of radiochemistry covers the following topics: Part 1: Actinides (metals) in biosystems; Part 2: Actinides in waste repositories. The research projects were aimed to the basic knowledge about coordination of actinide element transport and transfer in the environment, bacteria influence on the immobilization of heavy metals in water and soils, microbial diversity in biofilms and clays, protein applications for biosensors, dominating processes of soil-liquid interfaces, sorption and surface complexation processes.

Designing proteins for therapeutic applications.

Science.gov (United States)

Lazar, Greg A; Marshall, Shannon A; Plecs, Joseph J; Mayo, Stephen L; Desjarlais, John R

2003-08-01

Protein design is becoming an increasingly useful tool for optimizing protein drugs and creating novel biotherapeutics. Recent progress includes the engineering of monoclonal antibodies, cytokines, enzymes and viral fusion inhibitors.

The Annual Review of Information Science and Technology: Its Aims and Impact.

Science.gov (United States)

Cuadra, Carlos A.

The major aims of the "Annual Review of Information Science and Technology" are (1) to describe and appraise progress in information science and technology; (2) to provide a systematic, dependable tool that can relieve professionals from winnowing through a wealth of literature in their field each year; (3) to direct the reader to…

Quantitative proteomic analysis of paired colorectal cancer and non-tumorigenic tissues reveals signature proteins and perturbed pathways involved in CRC progression and metastasis.

Science.gov (United States)

Sethi, Manveen K; Thaysen-Andersen, Morten; Kim, Hoguen; Park, Cheol Keun; Baker, Mark S; Packer, Nicolle H; Paik, Young-Ki; Hancock, William S; Fanayan, Susan

2015-08-03

Modern proteomics has proven instrumental in our understanding of the molecular deregulations associated with the development and progression of cancer. Herein, we profile membrane-enriched proteome of tumor and adjacent normal tissues from eight CRC patients using label-free nanoLC-MS/MS-based quantitative proteomics and advanced pathway analysis. Of the 948 identified proteins, 184 proteins were differentially expressed (P1.5) between the tumor and non-tumor tissue (69 up-regulated and 115 down-regulated in tumor tissues). The CRC tumor and non-tumor tissues clustered tightly in separate groups using hierarchical cluster analysis of the differentially expressed proteins, indicating a strong CRC-association of this proteome subset. Specifically, cancer associated proteins such as FN1, TNC, DEFA1, ITGB2, MLEC, CDH17, EZR and pathways including actin cytoskeleton and RhoGDI signaling were deregulated. Stage-specific proteome signatures were identified including up-regulated ribosomal proteins and down-regulated annexin proteins in early stage CRC. Finally, EGFR(+) CRC tissues showed an EGFR-dependent down-regulation of cell adhesion molecules, relative to EGFR(-) tissues. Taken together, this study provides a detailed map of the altered proteome and associated protein pathways in CRC, which enhances our mechanistic understanding of CRC biology and opens avenues for a knowledge-driven search for candidate CRC protein markers. Copyright © 2015 Elsevier B.V. All rights reserved.

Progress of radiation curing technology and its industrial applications in Japan

International Nuclear Information System (INIS)

Takashi Ukachi

2007-01-01

The Japanese industry has grown with annual growth rate 108%. Electric parts and devices industry strongly promoted Japanese economy. UV/EB curing market in Japan enjoyed its steady growth with an annual growth rate 107%. By realizing the advantages of good performance and high functionality, the UV/EB curing technology has expanded its application field especially in leading edge industries, such as electric parts and devices, FPDs, Optical fibers and cables, optical recording media, and their fabrication and manufacturing. This paper summarizes the Japanese UV/EB market situation and overviews the latest progress of UV/EB technology. (Author)

US (United States) Army Aeromedical Research Laboratory Annual Progress Report, FY 1982.

Science.gov (United States)

1982-10-01

lr- mechan i SMS found i n caIda ver tcS t s Progress Fe work wa s compleoted and a repo rt i ssued. Ito data s:! lowoP! cod simil anf toy bet te en...filter contaminants known to exist in the operational environment. Physiological data, heart rate, oxygen tension and respiratory functions as well as

Nuclear Waste Treatment Program: Annual report for FY 1986

International Nuclear Information System (INIS)

Burkholder, H.C.; Brouns, R.A.; Powell, J.A.

1987-09-01

To support DOE's attainment of its goals, Nuclear Waste Treatment Program (NWTP) is to provide technology necessary for the design and operation of nuclear waste treatment facilities by commercial enterprises as part of a licensed waste management system and problem-specific treatment approaches, waste form and treatment process adaptations, equipment designs, and trouble-shooting. This annual report describes progress during FY 1986 toward meeting these two objectives. 29 refs., 59 figs., 25 tabs

Nuclear Waste Treatment Program: Annual report for FY 1986

Energy Technology Data Exchange (ETDEWEB)

Burkholder, H.C.; Brouns, R.A. (comps.); Powell, J.A. (ed.)

1987-09-01

To support DOE's attainment of its goals, Nuclear Waste Treatment Program (NWTP) is to provide technology necessary for the design and operation of nuclear waste treatment facilities by commercial enterprises as part of a licensed waste management system and problem-specific treatment approaches, waste form and treatment process adaptations, equipment designs, and trouble-shooting. This annual report describes progress during FY 1986 toward meeting these two objectives. 29 refs., 59 figs., 25 tabs.

DNA Copy-Number Control through Inhibition of Replication Fork Progression

Directory of Open Access Journals (Sweden)

Jared T. Nordman

2014-11-01

Full Text Available Proper control of DNA replication is essential to ensure faithful transmission of genetic material and prevent chromosomal aberrations that can drive cancer progression and developmental disorders. DNA replication is regulated primarily at the level of initiation and is under strict cell-cycle regulation. Importantly, DNA replication is highly influenced by developmental cues. In Drosophila, specific regions of the genome are repressed for DNA replication during differentiation by the SNF2 domain-containing protein SUUR through an unknown mechanism. We demonstrate that SUUR is recruited to active replication forks and mediates the repression of DNA replication by directly inhibiting replication fork progression instead of functioning as a replication fork barrier. Mass spectrometry identification of SUUR-associated proteins identified the replicative helicase member CDC45 as a SUUR-associated protein, supporting a role for SUUR directly at replication forks. Our results reveal that control of eukaryotic DNA copy number can occur through the inhibition of replication fork progression.

Phosphorylation of mitogen-activated protein kinase (MAPK) is required for cytokinesis and progression of cell cycle in tobacco BY-2 cells.

Science.gov (United States)

Ma, Zhaowu; Yu, Guanghui

2010-02-15

The role of mitogen-activated protein kinase (MAPK) in plant cytokinesis remains largely uncharacterized. To elucidate its role, tobacco Bright Yellow-2 (BY-2) cells have been synchronized using a two-step procedure, and the different phases of the cell cycle identified by Histone 4 gene expression and the mitotic index. MAPK expression was analyzed by semi-quantitative (SQ) RT-PCR and protein gel blot analysis for phosphorylated MAPK during cell cycle progression. The SQ RT-PCR analysis indicated that MAPK expression is lower in mitosis than in interphase (G1, G2 and S). However, the amount of phosphorylated MAPK remained stable throughout the cell cycle, indicating that MAPK activity is predominantly regulated at the post-translational level and that phosphorylation of MAPK plays an important role in mitosis. Application of the specific MAPK phosphorylation inhibitor U0126 revealed that while U0126 treatment decreases the phosphorylation of MAPK and the progression from telophase to early cytokinesis is significantly inhibited. The formation of the phragmoplast is also negatively affected at this stage. These results demonstrate that MAPK phosphorylation is involved in the formation of the cell plate within the phragmoplast during cytokinesis and that MAPK predominantly functions during the cytokinesis stage of the cell cycle in tobacco BY-2 cells. Copyright 2009 Elsevier GmbH. All rights reserved.

Protein-protein interaction network-based detection of functionally similar proteins within species.

Science.gov (United States)

Song, Baoxing; Wang, Fen; Guo, Yang; Sang, Qing; Liu, Min; Li, Dengyun; Fang, Wei; Zhang, Deli

2012-07-01

Although functionally similar proteins across species have been widely studied, functionally similar proteins within species showing low sequence similarity have not been examined in detail. Identification of these proteins is of significant importance for understanding biological functions, evolution of protein families, progression of co-evolution, and convergent evolution and others which cannot be obtained by detection of functionally similar proteins across species. Here, we explored a method of detecting functionally similar proteins within species based on graph theory. After denoting protein-protein interaction networks using graphs, we split the graphs into subgraphs using the 1-hop method. Proteins with functional similarities in a species were detected using a method of modified shortest path to compare these subgraphs and to find the eligible optimal results. Using seven protein-protein interaction networks and this method, some functionally similar proteins with low sequence similarity that cannot detected by sequence alignment were identified. By analyzing the results, we found that, sometimes, it is difficult to separate homologous from convergent evolution. Evaluation of the performance of our method by gene ontology term overlap showed that the precision of our method was excellent. Copyright © 2012 Wiley Periodicals, Inc.

25 CFR 30.116 - If a school fails to achieve its annual measurable objectives, what other methods may it use to...

Science.gov (United States)

2010-04-01

... participated in the assessment. (b) Method B—Uniform Averaging Procedure. A school may use uniform averaging... 25 Indians 1 2010-04-01 2010-04-01 false If a school fails to achieve its annual measurable... Adequate Yearly Progress § 30.116 If a school fails to achieve its annual measurable objectives, what other...

Annual coral bleaching and the long-term recovery capacity of coral

Science.gov (United States)

Schoepf, Verena; Grottoli, Andréa G.; Levas, Stephen J.; Aschaffenburg, Matthew D.; Baumann, Justin H.; Matsui, Yohei; Warner, Mark E.

2015-01-01

Mass bleaching events are predicted to occur annually later this century. Nevertheless, it remains unknown whether corals will be able to recover between annual bleaching events. Using a combined tank and field experiment, we simulated annual bleaching by exposing three Caribbean coral species (Porites divaricata, Porites astreoides and Orbicella faveolata) to elevated temperatures for 2.5 weeks in 2 consecutive years. The impact of annual bleaching stress on chlorophyll a, energy reserves, calcification, and tissue C and N isotopes was assessed immediately after the second bleaching and after both short- and long-term recovery on the reef (1.5 and 11 months, respectively). While P. divaricata and O. faveolata were able to recover from repeat bleaching within 1 year, P. astreoides experienced cumulative damage that prevented full recovery within this time frame, suggesting that repeat bleaching had diminished its recovery capacity. Specifically, P. astreoides was not able to recover protein and carbohydrate concentrations. As energy reserves promote bleaching resistance, failure to recover from annual bleaching within 1 year will likely result in the future demise of heat-sensitive coral species. PMID:26582020

Physics Department. Annual progress report 1 January - 31 December 1990

International Nuclear Information System (INIS)

Als-Nielsen, J.; Skov Pedersen, J.; Lebech, B.

1991-01-01

Research in the Physics Department covers the field of condensed matter physics. The principal activities of the department are presented in this Progress Report for the period from 1 January to 31 December 1990. The condensed matter physics research is predominantly experimental utilising diffraction of neutrons and X-rays. The research topics range from studies of two- and three-dimensional structures, magnetic ordering, heavy fermions, phase transitions in model systems to studies of texture and recrystallization kinetics with a more applie nature. In the field high T c superconductors neutron and X-ray diffraction are used both for studying the basic mechanism responsible for the superconductivity and in the analysis of the solid state syntheses of the materials. (author) 9 tabs., 79 ills., 104 refs

Annual progress report of the Department of Solid State Physics

International Nuclear Information System (INIS)

Als-Nielsen, J.; Skov Pedersen, J.; Lebech, B.

1992-01-01

Research in the department covers the field of condensed matter physics. The principal activities of the department are presented in the Progress Report covering the period from 1 January to 31 December 1991. The condensed matter physics research is predominantly experimental utilizing diffraction of neutrons and X-rays. The research topics range from studies of two- and three-dimensional structures, magnetic ordering, heavy femions, high T c superconductivity, phase transitions in model systems to studies of precipitation phenomena and nano-scale structures in various materials. The major interest of the department is in basic research, but projects of more applied nature are often taken up, prompted by the applicability of the developed technique and expertise. (au) 2 tabs., 94 ills., 82 refs

A closer look at urban transport. TERM 2013: transport indicators tracking progress towards environmental targets in Europe

Energy Technology Data Exchange (ETDEWEB)

Sanchez Vicente, A.

2013-12-01

The EEA works in the transport area to assess the impacts of the sector on the human health and the environment. This work also allows the EEA to monitor the progress of integrating transport and environmental policies, and informing the EU, EEA member countries and the public about such progress. This is achieved by the production of relevant indicators that track progress towards policy targets for transport related to the environment, as well as through the elaboration of periodic assessments that cover all transport modes and the impacts of transport on the environment. The annual TERM report aims to enable policymakers to gauge the progress of those policies aiming to improve the environmental performance of the transport system as a whole. TERM 2013, has two distinct parts. Part A provides an annual assessment of the EU's transport and environment policies based on the TERM-CSI, a selection of 12 indicators from the broader set of EEA transport indicators to enabling monitoring of the most important aspects of transport. Part B focuses on urban transport and its effects on the environment. (LN)

IPP annual report 1985/86

International Nuclear Information System (INIS)

1986-01-01

This annual report also is a review compiled on the occasion of the 25th anniversary of the Institute. A survey of tasks and activities of the IPP is followed by brief reports on the work in progress and on results achieved, dealing with the fundamentals of thermonuclear fusion, magnetic field configurations of the Tokamak device and stellarator device, and with the various components of a fusion experimental installation. Cooperative projects with other research institutes, the scientific infrastructure, the administrative organisation, services, and the activities of the management and of the scientific-technical office are other aspects forming part of the report. The organisational chart given is of November 1986. (GG) [de

Laser Program annual report 1984

Energy Technology Data Exchange (ETDEWEB)

Rufer, M.L.; Murphy, P.W. (eds.)

1985-06-01

The Laser Program Annual Report is part of the continuing series of reports documenting the progress of the unclassified Laser Fusion Program at the Lawrence Livermore National Laboratory (LLNL). As in previous years, the report is organized programmatically. The first section is an overview of the basic goals and directions of the LLNL Inertial Confinement Fusion (ICF) Program, and highlights the year's important accomplishments. Sections 2 through 7 provide the detailed information on the various program elements: Laser Systems and Operations, Target Design, Target Fabrication, Laser Experiments and Advanced Diagnostics, Advanced Laser Development, and Applications of Inertial Confinement Fusion. Individual sections will be indexed separately. 589 refs., 333 figs., 25 tabs.

California Energy Systems for the 21st Century 2016 Annual Report

Energy Technology Data Exchange (ETDEWEB)

Van Randwyk, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Boutelle, A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); McClelland, C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Weed, C. J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2017-03-25

The California Energy Systems for the 21st Century (CES-21) Program is a public-private collaborative research and development program between the California Joint Utilities1 and Lawrence Livermore National Laboratory (LLNL). The purpose of this annual report is to provide the California Public Utilities Commission (CPUC or Commission) with a summary of the 2016 progress of the CES-21 Program.

New candidate markers of head and neck squamous cell carcinoma progression

Science.gov (United States)

Kakurina, G. V.; Kolegova, E. S.; Cheremisina, O. V.; Kulbakin, D. E.; Choinzonov, E. L.

2017-09-01

The tumor progression in head and neck squamous cell carcinoma (HNSCC) is one of the main causes of high mortality of the patients with HNSCC. The tumor progression, particularly the metastasis, is characterized by the changes in the composition, functions and structure of different proteins. We have previously shown that serum of HNSCC patients contains the proteins which regulate various cellular processes—adenylyl cyclase associated protein 1 (CAP1), protein phosphatase 1 B (PPM1B), etc. The levels of CAP1 and PPM1B were determined using the enzyme immunoassay. The results of this study show that CAP1 and PPM1B take a part in the progression of HNSCC. The levels of CAP1 and PPM1B in the tumor and in morphologically normal tissue depended on the prevalence of the tumor process. The CAP1 and PPM1B levels were significantly higher in tumor tissue of the patients with regional metastasis. Our data allow assuming the potential possibility for predicting the outcome of the HNSCC measuring the level of tissue CAP1.

The movement protein and coat protein of alfalfa mosaic virus accumulate in structurally modified plasmodesmata

NARCIS (Netherlands)

van der Wel, N. N.; Goldbach, R. W.; van Lent, J. W.

1998-01-01

In systemically infected tissues of Nicotiana benthamiana, alfalfa mosaic virus (AMV) coat protein (CP) and movement protein (MP) are detected in plasmodesmata in a layer of three to four cells at the progressing front of infection. Besides the presence of these viral proteins, the plasmodesmata are

Geothermal Energy R&D Program Annual Progress Report Fiscal Year 1993

Energy Technology Data Exchange (ETDEWEB)

None

1994-04-01

In this report, the DOE Geothermal Program activities were split between Core Research and Industrial Development. The technical areas covered are: Exploration Technology, Drilling Technology, Reservoir Technology (including Hot Dry Rock Research and The Geyser Cooperation), and Conversion Technology (power plants, materials, and direct use/direct heat). Work to design the Lake County effluent pipeline to help recharge The Geysers shows up here for the first time. This Progress Report is another of the documents that are reasonable starting points in understanding many of the details of the DOE Geothermal Program. (DJE 2005)

Quarterly, Bi-annual and Annual Reports

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The Quarterly, Bi-annual and Annual Reports are periodic reports issued for public release. For the deep set fishery these reports are issued quarterly and anually....

Gas-Cooled Reactor Programs annual progress report for period ending December 31, 1973

International Nuclear Information System (INIS)

Kasten, P.R.; Coobs, J.H.; Lotts, A.L.

1976-04-01

Progress is summarized in studies relating to HTGR fuel reprocessing, refabrication, and recycle; HTGR fuel materials development and performance testing; HTGR PCRV development; HTGR materials investigations; HTGR fuel chemistry; HTGR safety studies; and GCFR irradiation experiments and steam generator modeling

National Institute for Global Environmental Change. Semi-annual report, July 1, 1991--December 31, 1991

Energy Technology Data Exchange (ETDEWEB)

Werth, G.C.

1992-04-01

This document is the Semi-Annual Report of the National Institute for Global Environmental Change for the reporting period July 1 to December 31, 1991. The report is in two parts. Part I presents the mission of the Institute, examples of progress toward that mission, a brief description of the revised management plan, and the financial report. Part II presents the statements of the Regional Center Directors along with progress reports of the projects written by the researchers themselves.

EDF group - annual report 2003; Groupe EDF - rapport annuel 2003

Energy Technology Data Exchange (ETDEWEB)

NONE

2004-07-01

This document contains the magazine, the financial statements and the sustainable development report of Electricite de France (EdF) group for 2003: 1 - the magazine (chairman's statement, group profile, vision and strategy); 2 - the consolidated financial statements for the period ended 31 December 2003 (statutory auditors' report on the consolidated financial statements, EDF's summary annual financial statements); 3 - sustainable development report (transparency and dialogue, responsibility, commitment, partnerships for progress). (J.S.)

Annual technical meeting of the NRC cooperative severe accident research program

International Nuclear Information System (INIS)

Silver, E.G.

1993-01-01

This brief report summarizes the 1992 annual technical meeting of the NRC Cooperative Severe Accident Research Program (CSARP-92) held at the Hyatt Regency Hotel in Bethesda, Maryland, May 4-8, 1992. The report is taken mainly from coverage of the meeting published in the June 5, 1992, issue of Atomic Energy Clearinghouse. Results of this meeting are formalized at the Water Reactor Safety Information Meetings (WRSIM) that are held annually in October. Nuclear Safety summarizes the annual WRSIM meetings and provides a list of the presentations that were given. Interested readers are encouraged to review listed topics to identify specific topic areas in severe accident research. Sessions were held on in-vessel core melt progression; fuel-coolant interactions; fission-product behavior; direct containment heating; and severe accident code development, assessment, and validation. Summaries of the individual technical sessions and the current state of the art in these areas were given by the chairmen

76 FR 64369 - Notice of Submission of Proposed Information Collection to OMB Annual Progress Reports for...

Science.gov (United States)

2011-10-18

... based on the progress reported in implementing the EZs' strategic plans. Businesses located in the EZs... based on the progress reported in implementing the EZs' strategic plans. Businesses located in the EZs... primary purpose of this collection is to continue current data reporting for Rounds, I, II, and III...

76 FR 66946 - Notice of Submission of Proposed Information Collection to OMB Annual Progress Reports for...

Science.gov (United States)

2011-10-28

... to HUD based on the progress reported in implementing the EZs' strategic plans. Businesses located in... based on the progress reported in implementing the EZs' strategic plans. Businesses located in the EZs.... The primary purpose of this collection is to continue current data reporting for Rounds, I, II, and...

Analytical Chemistry Division annual progress report for period ending December 31, 1985

International Nuclear Information System (INIS)

Shultz, W.D.

1986-05-01

Progress reports are presented for the four major sections of the division: analytical spectroscopy, radioactive materials laboratories, inorganic chemistry, and organic chemistry. A brief discussion of the division's role in the Laboratory's Environmental Restoration and Facilities Upgrade is given. Information about quality assurance and safety programs is presented, along with a tabulation of analyses rendered. Publications, oral presentations, professional activities, educational programs, and seminars are cited

Fossil Energy Program annual progress report for April 1997 through March 1998

Energy Technology Data Exchange (ETDEWEB)

Judkins, R.R.

1998-07-01

This report covers progress made on research and development projects that contribute to the advancement of fossil energy technologies, covering the areas of coal, clean coal technology, gas, petroleum, and support to the Strategic Petroleum Reserve (SPR). Papers are arranged under the following topical sections: materials research and development; environmental analysis support; bioprocessing research; fossil fuels supplies modeling and research; and oil and gas production.

Study of allosteric communications in chimeric two-domain proteins

Czech Academy of Sciences Publication Activity Database

Boušová, Kristýna

2017-01-01

Roč. 26, S1 (2017), s. 74 ISSN 0961-8368. [Annual Symposium of the Protein Society /31./. 24.07.2017-27.07.2017, Montreal] Institutional support: RVO:61388963 Keywords : protein domains * chimeric structures Subject RIV: CE - Biochemistry

Protein and protein hydrolysates in sports nutrition.

Science.gov (United States)

van Loon, Luc J C; Kies, Arie K; Saris, Wim H M

2007-08-01

With the increasing knowledge about the role of nutrition in increasing exercise performance, it has become clear over the last 2 decades that amino acids, protein, and protein hydrolysates can play an important role. Most of the attention has been focused on their effects at a muscular level. As these nutrients are ingested, however, it also means that gastrointestinal digestibility and absorption can modulate their efficacy significantly. Therefore, discussing the role of amino acids, protein, and protein hydrolysates in sports nutrition entails holding a discussion on all levels of the metabolic route. On May 28-29, 2007, a small group of researchers active in the field of exercise science and protein metabolism presented an overview of the different aspects of the application of protein and protein hydrolysates in sports nutrition. In addition, they were asked to share their opinions on the future progress in their fields of research. In this overview, an introduction to the workshop and a short summary of its outcome is provided.

Task I. Basic mirror studies. Task II. Basic tokamak studies. Annual progress report

International Nuclear Information System (INIS)

Smullin, L.D.; Bekefi, G.; Porkolab, M.

1979-01-01

Brief discussions of research progress are given for each of the following areas: (1) building equipment, (2) rf heating, (3) interferometry, (4) gas puffing, (5) mm collective scattering, (6) uv spectroscopy, (7) soft x radiation, (8) charge exchange, and (9) Thomson scattering

Annual report on reactor safety research projects sponsored by the Ministry for Research and Technology of the Federal Republic of Germany 1987

International Nuclear Information System (INIS)

1988-06-01

The GRS (Reactor Safety Association), Gesellschaft fuer Reaktorsicherheit mbH, by order of the BMFT, informs continuously of the status of such investigations by means of semi-annual and annual publication of progress reports within the series GRS-F-Fortschrittsberichte (GRS-F-Progress-Reports). Each progress report represents a compilation of individual reports about objectives, the work performed, the results, the next steps of the work etc. The individual reports are prepared in a standard form by the contractors themselves as a documentation of their progress in work and published by the FB (Research Coordination Department), Forschungsbetreuung at the GRS, within the framework of general information of progress in reactor safety research. The individual reports are classified according to the Research Program on the Safety of LWRs of the BMFT. Another table of contents uses the same classification system as applied in the Nuclear Safety Index of the CEC (Commission of the European Communities) and the OECD (Organization for Economic Cooperation and Development). The report are arranged in the sequence of their project numbers. (orig./HP) [de

Targeting protein-protein interaction between MLL1 and reciprocal proteins for leukemia therapy.

Science.gov (United States)

Wang, Zhi-Hui; Li, Dong-Dong; Chen, Wei-Lin; You, Qi-Dong; Guo, Xiao-Ke

2018-01-15

The mixed lineage leukemia protein-1 (MLL1), as a lysine methyltransferase, predominantly regulates the methylation of histone H3 lysine 4 (H3K4) and functions in hematopoietic stem cell (HSC) self-renewal. MLL1 gene fuses with partner genes that results in the generation of MLL1 fusion proteins (MLL1-FPs), which are frequently detected in acute leukemia. In the progress of leukemogenesis, a great deal of proteins cooperate with MLL1 to form multiprotein complexes serving for the dysregulation of H3K4 methylation, the overexpression of homeobox (HOX) cluster genes, and the consequent generation of leukemia. Hence, disrupting the interactions between MLL1 and the reciprocal proteins has been considered to be a new treatment strategy for leukemia. Here, we reviewed potential protein-protein interactions (PPIs) between MLL1 and its reciprocal proteins, and summarized the inhibitors to target MLL1 PPIs. The druggability of MLL1 PPIs for leukemia were also discussed. Copyright © 2017. Published by Elsevier Ltd.

Foreword and introductory comments to CEA annual report 1989

International Nuclear Information System (INIS)

1990-01-01

This article is a foreword to the annual report of the Commisariat a l'Energie Atomique (CEA) and summarises the main achievements of the research teams such as the commissioning of the electron-positron collision ring (LEP), the fuel reprocessing plant at The Hague, the PROTEINE 2000 programme, the laser enrichment programme and advances in microelectronics. (author)

Progress report within the series of GRS-F progress reports on reactor safety, sponsored by the Federal Ministry of Economics and Technology. Period: 1 January - 30 June, 2002

International Nuclear Information System (INIS)

2002-01-01

Within its competence for energy research, the Bundesministerium fuer Wirtschaft und Technologie (BMWi) (Federal Ministry of Economics and Technology) sponsors investigations into the safety of nuclear power plants. The objective of these investigations is to provide fundamental knowledge, procedures and methods to contribute to realistic safety assessments of nuclear installations, to the further development of safety technology and to make use of the potential of innovative safety-related approaches. The Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH, by order to the BMWi, continuously issues information on the status of such investigations by publishing semi-annual and annual progress reports within the series of GRS-F-Fortschrittsberichte (GRS-F-Progress Reports). Each progress report represents a compilation of individual reports about the objectives, work performed, results achieved, next steps of the work etc. The individual reports are prepared in a standard form by the research organisations themselves as documentation of their progress in work and are published by the Research Managment Division of GRS within the framework of general information on the progress in reactor safety research. The compilation of the reports is classified according to general topics related to reactor safety research. Further, use is made of the classification system 'Joint Safety Research Index' of the CEC (Commission of the European Communities). The reports are arranged in sequence of their project numbers. It has to be pointed out that the authors of the reports are responsible for the contents of this compilation. The BMWi does not take any responsibility for the correctness, exactness and completeness of the information nor for the observance of private claims of third parties. (orig.) [de

Progress report within the series of GRS-F progress reports on reactor safety, sponsored by the Federal Ministry of Economics and Technology. Period: 1 July - 31 December 2001

International Nuclear Information System (INIS)

2002-01-01

Within its competence for energy research, the Bundesministerium fuer Wirtschaft und Technologie (BMWi) (Federal Ministry of Economics and Technology) sponsors investigations into the safety of nuclear power plants. The objective of these investigations is to provide fundamental knowledge, procedures and methods to contribute to realistic safety assessments of nuclear installations, to the further development of safety technology and to make use of the potential of innovative safety-related approaches. The Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH, by order to the BMWi, continuously issues information on the status of such investigations by publishing semi-annual and annual progress reports within the series of GRS-F-Fortschrittsberichte (GRS-F-Progress Reports). Each progress report represents a compilation of individual reports about the objectives, work performed, results achieved, next steps of the work etc. The individual reports are prepared in a standard form by the research organisations themselves as documentation of their progress in work and are published by the Research Managment Division of GRS within the framework of general information on the progress in reactor safety research. The compilation of the reports is classified according to general topics related to reactor safety research. Further, use is made of the classification system 'Joint Safety Research Index' of the CEC (Commission of the European Communities). The reports are arranged in sequence of their project numbers. It has to be pointed out that the authors of the reports are responsible for the contents of this compilation. The BMWi does not take any responsibility for the correctness, exactness and completeness of the information nor for the observance of private claims of third parties. (orig.) [de

High Protein Diet and Huntington's Disease

Science.gov (United States)

Wu, Yih-Ru; Chen, Pei; Tsai, Fuu-Jen; Yang, Chueh-Lien; Tsao, Ya-Tzu; Chang, Wen; Hsieh, I-Shan; Chern, Yijuang; Soong, Bing-Wen

2015-01-01

Huntington’s disease (HD) is a neurodegenerative disorder caused by the huntingtin (HTT) gene with expanded CAG repeats. In addition to the apparent brain abnormalities, impairments also occur in peripheral tissues. We previously reported that mutant Huntingtin (mHTT) exists in the liver and causes urea cycle deficiency. A low protein diet (17%) restores urea cycle activity and ameliorates symptoms in HD model mice. It remains unknown whether the dietary protein content should be monitored closely in HD patients because the normal protein consumption is lower in humans (~15% of total calories) than in mice (~22%). We assessed whether dietary protein content affects the urea cycle in HD patients. Thirty HD patients were hospitalized and received a standard protein diet (13.7% protein) for 5 days, followed by a high protein diet (HPD, 26.3% protein) for another 5 days. Urea cycle deficiency was monitored by the blood levels of citrulline and ammonia. HD progression was determined by the Unified Huntington’s Disease Rating Scale (UHDRS). The HPD increased blood citrulline concentration from 15.19 μmol/l to 16.30 μmol/l (p = 0.0378) in HD patients but did not change blood ammonia concentration. A 2-year pilot study of 14 HD patients found no significant correlation between blood citrulline concentration and HD progression. Our results indicated a short period of the HPD did not markedly compromise urea cycle function. Blood citrulline concentration is not a reliable biomarker of HD progression. PMID:25992839

High Protein Diet and Huntington's Disease.

Directory of Open Access Journals (Sweden)

Chiung-Mei Chen

Full Text Available Huntington's disease (HD is a neurodegenerative disorder caused by the huntingtin (HTT gene with expanded CAG repeats. In addition to the apparent brain abnormalities, impairments also occur in peripheral tissues. We previously reported that mutant Huntingtin (mHTT exists in the liver and causes urea cycle deficiency. A low protein diet (17% restores urea cycle activity and ameliorates symptoms in HD model mice. It remains unknown whether the dietary protein content should be monitored closely in HD patients because the normal protein consumption is lower in humans (~15% of total calories than in mice (~22%. We assessed whether dietary protein content affects the urea cycle in HD patients. Thirty HD patients were hospitalized and received a standard protein diet (13.7% protein for 5 days, followed by a high protein diet (HPD, 26.3% protein for another 5 days. Urea cycle deficiency was monitored by the blood levels of citrulline and ammonia. HD progression was determined by the Unified Huntington's Disease Rating Scale (UHDRS. The HPD increased blood citrulline concentration from 15.19 μmol/l to 16.30 μmol/l (p = 0.0378 in HD patients but did not change blood ammonia concentration. A 2-year pilot study of 14 HD patients found no significant correlation between blood citrulline concentration and HD progression. Our results indicated a short period of the HPD did not markedly compromise urea cycle function. Blood citrulline concentration is not a reliable biomarker of HD progression.

Annual report of waste generation and pollution prevention progress 1998

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-09-01

This seventh Annual Report presents and analyzes DOE Complex-wide waste generation and pollution prevention activities at 45 reporting sites from 1993 through 1998. This section summarizes Calendar Year 1998 Complex-wide waste generation and pollution prevention accomplishments. More detailed information follows this section in the body of the Report. In May 1996, the Secretary of Energy established a 50 percent Complex-Wide Waste Reduction Goal (relative to the 1993 baseline) for routine operations radioactive, mixed, and hazardous waste generation, to be achieved by December31, 1999. DOE has achieved its Complex-Wide Waste Reduction Goals for routine operations based upon a comparison of 1998 waste generation to the 1993 baseline. Excluding sanitary waste, routine operations waste generation decreased 67 percent overall from 1993 to 1998. However, for the first time since 1994, the total amount of materials recycled by the Complex decreased from 109,600 metric tons in 1997 to 92,800 metric tons in 1998. This decrease is attributed to the fact that in 1997, several large ''one-time only'' recycling projects were conducted throughout the Complex. In order to demonstrate commitment to DOE's Complex-wide recycling goal, it is important for sites to identify all potential large-scale recycling/reuse opportunities.

FBR Plant Engineering Center annual report 2012

International Nuclear Information System (INIS)

2013-12-01

This annual report shows the last year's R and D activities of currently-reorganized FBR Plant Engineering Center, which was established on April 1, 2009. FBR Safety Technology Center was founded on April 1, 2013 by the consolidation of both the activities of 'former FBR Plant Engineering Center' and a portion of 'FBR Safety Evaluation Unit, Advanced Nuclear System Research and Development Directorate', especially concentrating on safety evaluations and analyses for severe accidents. As for FBR safety technology, it is necessary to continuously make an effort for compliance with new safety regulations in preparation for 'Monju' to restart, for safety enhancement evaluation and for safety technology upgrading. In this context, the new organization was founded in order to reinforce the safety evaluation capability, which will surely and steadily promote FBR safety-technology related activities. As a result, FBR Plant Engineering Center was abolished. This report summarizes the R and D activities at the former FBR Plant Engineering Center, aiming at contributing to the commercialization by using operation experiences and technology development results derived from the actual reactor 'Monju'. The activities are divided into five areas of operation-and-maintenance engineering, sodium engineering, reactor-core-and-fuel engineering, plant engineering, and safety engineering. This annual report is intended for a report of the activities of individual researcher in the center rather than that of the progress of the center as a whole. This will clarify the individual themes, progresses and problems of each researcher, which will, hopefully, facilitate communication with the outside researchers. (author)

2011 Annual Progress Report: DOE Hydrogen and Fuel Cells Program (Book)

Energy Technology Data Exchange (ETDEWEB)

2011-11-01

In the past year, the DOE Hydrogen and Fuel Cells Program (the Program) made substantial progress toward its goals and objectives. The Program has conducted comprehensive and focused efforts to enable the widespread commercialization of hydrogen and fuel cell technologies in diverse sectors of the economy. With emphasis on applications that will effectively strengthen our nation's energy security and improve our stewardship of the environment, the Program engages in research, development, and demonstration of critical improvements in the technologies. Highlights of the Program's accomplishments can be found in the sub-program chapters of this report.

Fossil Energy Program annual progress report for April 1995 through March 1996

Energy Technology Data Exchange (ETDEWEB)

Judkins, R.R.

1996-06-01

This report covers progress for research and development projects that contribute to the advancement of various fossil energy technologies. Attention is focused on the following areas: materials research and development; environmental analysis support; bioprocessing research for coal, oil, and natural gas; coal combustion research; fossil fuels supplies modeling and research; and advanced turbine systems. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

Analytical Chemistry Division annual progress report for period ending December 31, 1985

Energy Technology Data Exchange (ETDEWEB)

Shultz, W.D.

1986-05-01

Progress reports are presented for the four major sections of the division: analytical spectroscopy, radioactive materials laboratories, inorganic chemistry, and organic chemistry. A brief discussion of the division's role in the Laboratory's Environmental Restoration and Facilities Upgrade is given. Information about quality assurance and safety programs is presented, along with a tabulation of analyses rendered. Publications, oral presentations, professional activities, educational programs, and seminars are cited.

Liver Inflammation and Metabolic Signaling in ApcMin/+ Mice: The Role of Cachexia Progression

Science.gov (United States)

Narsale, Aditi A.; Enos, Reilly T.; Puppa, Melissa J.; Chatterjee, Saurabh; Murphy, E. Angela; Fayad, Raja; Pena, Majorette O’; Durstine, J. Larry; Carson, James A.

2015-01-01

The ApcMin/+ mouse exhibits an intestinal tumor associated loss of muscle and fat that is accompanied by chronic inflammation, insulin resistance and hyperlipidemia. Since the liver governs systemic energy demands through regulation of glucose and lipid metabolism, it is likely that the liver is a pathological target of cachexia progression in the ApcMin/+ mouse. The purpose of this study was to determine if cancer and the progression of cachexia affected liver endoplasmic reticulum (ER)-stress, inflammation, metabolism, and protein synthesis signaling. The effect of cancer (without cachexia) was examined in wild-type and weight-stable ApcMin/+ mice. Cachexia progression was examined in weight-stable, pre-cachectic, and severely-cachectic ApcMin/+ mice. Livers were analyzed for morphology, glycogen content, ER-stress, inflammation, and metabolic changes. Cancer induced hepatic expression of ER-stress markers BiP (binding immunoglobulin protein), IRE-1α (endoplasmic reticulum to nucleus signaling 1), and inflammatory intermediate STAT-3 (signal transducer and activator of transcription 3). While gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PEPCK) mRNA expression was suppressed by cancer, glycogen content or protein synthesis signaling remained unaffected. Cachexia progression depleted liver glycogen content and increased mRNA expression of glycolytic enzyme PFK (phosphofrucktokinase) and gluconeogenic enzyme PEPCK. Cachexia progression further increased pSTAT-3 but suppressed p-65 and JNK (c-Jun NH2-terminal kinase) activation. Interestingly, progression of cachexia suppressed upstream ER-stress markers BiP and IRE-1α, while inducing its downstream target CHOP (DNA-damage inducible transcript 3). Cachectic mice exhibited a dysregulation of protein synthesis signaling, with an induction of p-mTOR (mechanistic target of rapamycin), despite a suppression of Akt (thymoma viral proto-oncogene 1) and S6 (ribosomal protein S6) phosphorylation. Thus, cancer

Liver inflammation and metabolic signaling in ApcMin/+ mice: the role of cachexia progression.

Directory of Open Access Journals (Sweden)

Aditi A Narsale

Full Text Available The ApcMin/+ mouse exhibits an intestinal tumor associated loss of muscle and fat that is accompanied by chronic inflammation, insulin resistance and hyperlipidemia. Since the liver governs systemic energy demands through regulation of glucose and lipid metabolism, it is likely that the liver is a pathological target of cachexia progression in the ApcMin/+ mouse. The purpose of this study was to determine if cancer and the progression of cachexia affected liver endoplasmic reticulum (ER-stress, inflammation, metabolism, and protein synthesis signaling. The effect of cancer (without cachexia was examined in wild-type and weight-stable ApcMin/+ mice. Cachexia progression was examined in weight-stable, pre-cachectic, and severely-cachectic ApcMin/+ mice. Livers were analyzed for morphology, glycogen content, ER-stress, inflammation, and metabolic changes. Cancer induced hepatic expression of ER-stress markers BiP (binding immunoglobulin protein, IRE-1α (endoplasmic reticulum to nucleus signaling 1, and inflammatory intermediate STAT-3 (signal transducer and activator of transcription 3. While gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PEPCK mRNA expression was suppressed by cancer, glycogen content or protein synthesis signaling remained unaffected. Cachexia progression depleted liver glycogen content and increased mRNA expression of glycolytic enzyme PFK (phosphofrucktokinase and gluconeogenic enzyme PEPCK. Cachexia progression further increased pSTAT-3 but suppressed p-65 and JNK (c-Jun NH2-terminal kinase activation. Interestingly, progression of cachexia suppressed upstream ER-stress markers BiP and IRE-1α, while inducing its downstream target CHOP (DNA-damage inducible transcript 3. Cachectic mice exhibited a dysregulation of protein synthesis signaling, with an induction of p-mTOR (mechanistic target of rapamycin, despite a suppression of Akt (thymoma viral proto-oncogene 1 and S6 (ribosomal protein S6 phosphorylation. Thus

Annual Progress Report, 1976. Southern Rural Development Center, Mississippi State University. SRDC Series Publication No. 15.

Science.gov (United States)

Southern Rural Development Center, State College, MS.

Covering the 1976 activities of the Southern Rural Development Center (SRDC), this third annual report describes SRDC's: history; organization; regional workshops; functional networks; network bibliographies and other publications; Title V reports; grant received for training in rural development; orientation visits; consultants; information…

Animal proteins in feed : IAG ring rest 2011

NARCIS (Netherlands)

Raamsdonk, van L.W.D.; Pinckaers, V.G.Z.; Vliege, J.J.M.; Ruth, van S.M.

2011-01-01

The International Association for Feeding stuff Analysis, section Feeding stuff Microscopy, organises annually a ring test for animal proteins for all their members. In this report the ring test for animal proteins is presented, which was organised by RIKILT in 2011 on behalf of the IAG section

Ecological requirements for pallid sturgeon reproduction and recruitment in the Lower Missouri River: Annual report 2010

Science.gov (United States)

DeLonay, Aaron J.; Jacobson, Robert B.; Papoulias, Diana M.; Wildhaber, Mark L.; Chojnacki, Kimberly A.; Pherigo, Emily K.; Haas, Justin D.; Mestl, Gerald E.

2012-01-01

The Comprehensive Sturgeon Research Project is a multiyear, multiagency collaborative research framework developed to provide information to support pallid sturgeon recovery and Missouri River management decisions. The project strategy integrates field and laboratory studies of sturgeon reproductive ecology, early life history, habitat requirements, and physiology. The project scope of work is developed annually with cooperating research partners and in collaboration with the U.S. Army Corps of Engineers, Missouri River Recovery—Integrated Science Program. The research consists of several interdependent and complementary tasks that engage multiple disciplines. The research tasks in the 2010 scope of work primarily address spawning as a probable factor limiting pallid sturgeon survival and recovery, although limited pilot studies also have been initiated to examine the requirements of early life stages. The research is designed to inform management decisions affecting channel re-engineering, flow modification, and pallid sturgeon population augmentation on the Missouri River, and throughout the range of the species. Research and progress made through this project are reported to the U.S. Army Corps of Engineers annually. This annual report details the research effort and progress made by the Comprehensive Sturgeon Research Project during 2010.

Progressing neurobiological strategies against proteostasis failure: Challenges in neurodegeneration.

Science.gov (United States)

Amanullah, Ayeman; Upadhyay, Arun; Joshi, Vibhuti; Mishra, Ribhav; Jana, Nihar Ranjan; Mishra, Amit

2017-12-01

Proteins are ordered useful cellular entities, required for normal health and organism's survival. The proteome is the absolute set of cellular expressed proteins, which regulates a wide range of physiological functions linked with all domains of life. In aging cells or under unfavorable cellular conditions, misfolding of proteins generates common pathological events linked with neurodegenerative diseases and aging. Current advances of proteome studies systematically generates some progress in our knowledge that how misfolding of proteins or their accumulation can contribute to the impairment or depletion of proteome functions. Still, the underlying causes of this unrecoverable loss are not clear that how such unsolved transitions give rise to multifactorial challengeable degenerative pathological conditions in neurodegeneration. In this review, we specifically focus and systematically summarize various molecular mechanisms of proteostasis maintenance, as well as discuss progressing neurobiological strategies, promising natural and pharmacological candidates, which can be useful to counteract the problem of proteopathies. Our article emphasizes an urgent need that now it is important for us to recognize the fundamentals of proteostasis to design a new molecular framework and fruitful strategies to uncover how the proteome defects are associated with aging and neurodegenerative diseases. A enhance understanding of progress link with proteome and neurobiological challenges may provide new basic concepts in the near future, based on pharmacological agents, linked with impaired proteostasis and neurodegenerative diseases. Copyright © 2017 Elsevier Ltd. All rights reserved.

Generation 4 International Forum. 2014 Annual Report

International Nuclear Information System (INIS)

2015-01-01

This eighth edition of the Generation IV International Forum (GIF) Annual Report highlights the main achievements of the Forum in 2014, and in particular progress made in the collaborative RandD activities of the eleven existing project arrangements for the six GIF systems: the gas-cooled fast reactor, the sodium-cooled fast reactor, the supercritical-water-cooled reactor and the very-high-temperature reactor. Progress made under the memoranda of understanding for the lead-cooled fast reactor and the molten salt reactor is also reported. In May 2014, China joined the supercritical-water-cooled reactor system arrangement; and in October 2014, the project arrangement on system integration and assessment for the sodium-cooled fast reactor became effective. GIF also continued to develop safety design criteria and guidelines for the sodium-cooled fast reactor, and to engage with regulators on safety approaches for generation IV systems. Finally, GIF initiated an internal discussion on sustainability approaches to complement ongoing work on economics, safety, proliferation resistance and physical protection

Annual Report: Photovoltaic Subcontract Program FY 1990

Energy Technology Data Exchange (ETDEWEB)

Summers, K. A. [Solar Energy Research Inst., Golden, CO (United States)

1991-03-01

This report summarizes the progress of the Photovoltaic (PV) Subcontract Program of the Solar Energy Research Institute (SERI) from October 1, 1989 through September 30, 1990. The PV Subcontract Program is responsible for managing the subcontracted portion of SERI's PV Advanced Research and Development Project. In fiscal year 1990, this included more than 54 subcontracts with a total annualized funding of approximately $11.9 million. Approximately two-thirds of the subcontracts were with universities at a total funding of nearly $3.3 million. The six technical sections of the report cover the main areas of the subcontract program: the Amorphous Silicon Research Project, Polycrystalline Thin Films, Crystalline Silicon Materials Research, High-Efficiency Concepts, the New Ideas Program, and the University Participation Program. Technical summaries of each of the subcontracted programs provide a discussion of approaches, major accomplishments in FY 1990, and future research directions. Another section introduces the PVMaT project and reports on its progress.

1994 annual report on low-level radioactive waste management progress

International Nuclear Information System (INIS)

1995-04-01

This report for calendar year 1994 summarizes the progress that states and compact regions made during the year in establishing new low-level radioactive waste disposal facilities. Although events that have occurred in 1995 greatly alter the perspective in terms of storage versus disposal, the purpose of this report is to convey the concerns as evidenced during calendar year 1994. Significant developments occurring in 1995 are briefly outlined in the transmittal letter and will be detailed in the report for calendar year 1995. The report also provides summary information on the volume of low-level radioactive waste received for disposal in 1994 by commercially operated low-level radioactive waste disposal facilities, and is prepared is in response to Section 7(b) of Title I of Public Law 99-240, the Low-Level Radioactive Waste Policy Amendments Act of 1985

Atomic Energy of Canada Limited annual report 2000-2001

International Nuclear Information System (INIS)

2001-01-01

This is the annual report of the Atomic Energy of Canada Limited for the year ending March 31, 2001 and summarizes the activities of AECL during the period 2000-2001. The activities covered in this report include the CANDU reactor business, with progress being reported in the construction of two CANDU 6 reactors for the Qinshan CANDU project in China, the anticipated completion of Cernavoda unit 2, the completion of spent fuel storage at Cernavoda unit 1 in Romania, as well as the service business with New Brunswick Power, Ontario Power Generation, Bruce Power and Hydro Quebec in the refurbishment of operating, CANDU reactors. In the R and D programs discussions continue on funding for the Canadian Neutron Facility for Materials Research (CNF) and progress on the Maple medical isotope reactor

Atomic Energy of Canada Limited annual report 2000-2001

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-07-01

This is the annual report of the Atomic Energy of Canada Limited for the year ending March 31, 2001 and summarizes the activities of AECL during the period 2000-2001. The activities covered in this report include the CANDU reactor business, with progress being reported in the construction of two CANDU 6 reactors for the Qinshan CANDU project in China, the anticipated completion of Cernavoda unit 2, the completion of spent fuel storage at Cernavoda unit 1 in Romania, as well as the service business with New Brunswick Power, Ontario Power Generation, Bruce Power and Hydro Quebec in the refurbishment of operating, CANDU reactors. In the R and D programs discussions continue on funding for the Canadian Neutron Facility for Materials Research (CNF) and progress on the Maple medical isotope reactor.

Physiological exercise loading suppresses post-traumatic osteoarthritis progression via an increase in bone morphogenetic proteins expression in an experimental rat knee model.

Science.gov (United States)

Iijima, H; Ito, A; Nagai, M; Tajino, J; Yamaguchi, S; Kiyan, W; Nakahata, A; Zhang, J; Wang, T; Aoyama, T; Nishitani, K; Kuroki, H

2017-06-01

To evaluate the dose-response relationship of exercise loading in the cartilage-subchondral bone (SB) unit in surgically-induced post-traumatic osteoarthritis (PTOA) of the knee. Destabilized medial meniscus (DMM) surgery was performed on the right knee of 12-week-old male Wistar rats, and sham surgery was performed on the contralateral knee. Four weeks after the surgery, the animals were subjected to moderate (12 m/min) or intense (21 m/min) treadmill exercises for 30 min/day, 5 days/week for 4 weeks. PTOA development in articular cartilage and SB was examined using histological and immunohistochemical analyses, micro-computed tomography (micro-CT) analysis, and biomechanical testing at 8 weeks after surgery. Gremlin-1 was injected to determine the role of bone morphogenetic protein (BMP) signaling on PTOA development following moderate exercise. Moderate exercise increased BMP-2, BMP-4, BMP-6, BMP receptor 2, pSmad-5, and inhibitor of DNA binding protein-1 expression in the superficial zone chondrocytes and suppressed cartilage degeneration, osteophyte growth, SB damage, and osteoclast-mediated SB resorption. However, intense exercise had little effect on BMP expression and even caused progression of these osteoarthritis (OA) changes. Gremlin-1 injection following moderate exercise caused progression of the PTOA development down to the level of the non-exercise DMM-operated knee. Exercise regulated cartilage-SB PTOA development in DMM-operated knees in a dose-dependent manner. Our findings shed light on the important role of BMP expression in superficial zone chondrocytes in attenuation of PTOA development following physiological exercise loading. Further studies to support a mechanism by which BMPs would be beneficial in preventing PTOA progression are warranted. Copyright © 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

Mechanism involved in trichloroethylene-induced liver cancer: Importance to environmental cleanup. 1997 annual progress report

International Nuclear Information System (INIS)

Bull, R.J.

1997-01-01

'The Pacific Northwest National Lab. was awarded ten (10) Environmental Management Science Program (EMSP) research grants in Fiscal Year 1996. This section gives a summary of how each grant is addressing significant DOE cleanup issues, including those at the Hanford Site. The technical progress made to date in each of these research projects is addressed in more detail in the individual progress reports contained in this document. This research is primarily focused in three areas-Tank Waste Remediation, Soil and Groundwater Cleanup, and Health Effects.'

Mechanism involved in trichloroethylene-induced liver cancer: Importance to environmental cleanup. 1997 annual progress report

Energy Technology Data Exchange (ETDEWEB)

Bull, R.J.

1997-06-01

'The Pacific Northwest National Lab. was awarded ten (10) Environmental Management Science Program (EMSP) research grants in Fiscal Year 1996. This section gives a summary of how each grant is addressing significant DOE cleanup issues, including those at the Hanford Site. The technical progress made to date in each of these research projects is addressed in more detail in the individual progress reports contained in this document. This research is primarily focused in three areas-Tank Waste Remediation, Soil and Groundwater Cleanup, and Health Effects.'

Research in elementary particle physics at the University of Florida: Annual progress report

International Nuclear Information System (INIS)

1988-01-01

This is a progress report on the Elementary Particle Physics program at the University of Florida. The program has five tasks covering a broad range of topics in theoretical and experimental high energy physics: Theoretical Elementary Particle Physics, Experimental High Energy Physics, Axion Search, Detector Development, and Computer Requisition

[Regulation of terpene metabolism]. Annual progress report, March 15, 1988--March 14, 1989

Energy Technology Data Exchange (ETDEWEB)

Croteau, R.

1989-12-31

Progress in understanding of the metabolism of monoterpenes by peppermint and spearmint is recorded including the actions of two key enzymes, geranyl pyrophosphate:limonene cyclase and a UDP-glucose dependent glucosyl transferase; concerning the ultrastructure of oil gland senescence; enzyme subcellular localization; regulation of metabolism; and tissue culture systems.

Natural History of Progression of Chronic Kidney Disease in Stages ...

African Journals Online (AJOL)

Natural History of Progression of Chronic Kidney Disease in Stages 4 and 5. ... Conclusion: Low serum bicarbonate level and high urinary protein excretion at baseline are independent predictors of progression in stage 4 and 5 CKD. Keywords: Chronic kidney disease; End stage renal disease; Glomerular filtration rate; ...

Review of Studies on Corporate Annual Reports During 1990-2012

OpenAIRE

Atefeh Mobasher; Afida Mohamad Ali; Faiz Sathi Abdullah; Chan Mei Yuit

2013-01-01

Corporate Annual Reports (CARs) are corporate communication tools which have been around for 75 years. They report company’s progress, profits and losses. At first, reports were provided in English, because they were published in an English speaking context. After a while, non-English speaking companies started to publish CARs in English to attract international investments. So far studies on CARs considered themes in text and images of CARs, subgenres of CARs, rhetorical construction, discou...

Comparative genomic analyses of transport proteins encoded within the genomes of Leptospira species.

Science.gov (United States)

Buyuktimkin, Bora; Saier, Milton H

2015-11-01

Select species of the bacterial genus Leptospira are causative agents of leptospirosis, an emerging global zoonosis affecting nearly one million people worldwide annually. We examined two Leptospira pathogens, Leptospira interrogans serovar Lai str. 56601 and Leptospira borgpetersenii serovar Hardjo-bovis str. L550, as well as the free-living leptospiral saprophyte, Leptospira biflexa serovar Patoc str. 'Patoc 1 (Ames)'. The transport proteins of these leptospires were identified and compared using bioinformatics to gain an appreciation for which proteins may be related to pathogenesis and saprophytism. L. biflexa possesses a disproportionately high number of secondary carriers for metabolite uptake and environmental adaptability as well as an increased number of inorganic cation transporters providing ionic homeostasis and effective osmoregulation in a rapidly changing environment. L. interrogans and L. borgpetersenii possess far fewer transporters, but those that they have are remarkably similar, with near-equivalent representation in most transporter families. These two Leptospira pathogens also possess intact sphingomyelinases, holins, and virulence-related outer membrane porins. These virulence-related factors, in conjunction with decreased transporter substrate versatility, indicate that pathogenicity was accompanied by progressively narrowing ecological niches and the emergence of a limited set of proteins responsible for host invasion. The variability of host tropism and mortality rates by infectious leptospires suggests that small differences in individual sets of proteins play important physiological and pathological roles. Copyright © 2015 Elsevier Ltd. All rights reserved.

Annual all-cause mortality rate for patients with diabetic kidney disease in Singapore

Directory of Open Access Journals (Sweden)

Yee Gary Ang

2016-06-01

Conclusion: Our study estimated the annual all-cause mortality rate for Singaporean patients with diabetic kidney disease by CKD stages and identified predictors of all-cause mortality. This study has affirmed the poor prognosis of these patients and an urgency to intervene early so as to retard the progression to later stages of CKD.

Environmental Sciences Division annual progress report for period ending September 30, 1992

International Nuclear Information System (INIS)

1993-04-01

This progress report summarizes the research and development activities conducted in the Environmental Sciences Division of Oak Ridge National Laboratory during fiscal year (FY) 1992, which which extended from October 1, 1991, through September 30, 1992. This report is structured to provide descriptions of current activities and accomplishments in each of the division's major organizational units. Section activities are described in the Earth and Atmospheric sciences, ecosystem studies, Environmental analysis, environmental biotechnology, and division operations

Biomedical engineering support. Annual progress report, August 15, 1975--August 14, 1976

International Nuclear Information System (INIS)

Kolff, W.J.; Smith, L.M.; Sandquist, G.

1976-12-01

The basic goal of the ERDA Artificial Heart Program is to develop and fabricate an Artificial Heart System for animal experiments. These future experiments and studies would be directed at developing and evaluating a satisfactory radioisotope-powered system for total heart replacement in humans. Research progress is reported on the program including 11 total heart replacement experiments performed in calves using the ERDA blood pump powered by an electric motor implanted in the abdomen

StreamNet; 1999 Annual Report.

Energy Technology Data Exchange (ETDEWEB)

Columbia River Inter-Tribal Fish Commission

2000-01-01

This report was funded by the Bonneville Power Administration (BPA), US Department of Energy, as part of BPA's program to protect, mitigate, and enhance fish and wildlife affected by the development and operation of hydroelectric facilities on the Columbia River and its tributaries. The views of this report are the author's and do not necessarily represent the views of BPA. This annual report covers progress made by: Columbia River Inter-Tribal Fish Commission Idaho; Department of Fish and Game; Montana Department of Fish, Wildlife and Parks; Oregon Department of Fish and Wildlife; Pacific States Marine Fisheries Commission; Shoshone-Bannock Tribes; US Fish and Wildlife Service; Washington Department of Fish and Wildlife; and FY1999 StreamNet Quickplan.

Progress in surface and membrane science

CERN Document Server

Danielli, J F; Cadenhead, D A

1973-01-01

Progress in Surface and Membrane Science, Volume 6 covers the developments in the study of surface and membrane science. The book discusses the progress in surface and membrane science; the solid state chemistry of the silver halide surface; and the experimental and theoretical aspects of the double layer at the mercury-solution interface. The text also describes contact-angle hysteresis; ion binding and ion transport produced by neutral lipid-soluble molecules; and the biophysical interactions of blood proteins with polymeric and artificial surfaces. Physical chemists, biophysicists, and phys

China institute of atomic energy annual report (1996)

International Nuclear Information System (INIS)

1997-01-01

The major achievements on scientific researches and production of CIAE during the year of 1996 was summarized in this annual report. It includes nuclear physics, high power laser, electro-physics reactor science and technology, radiochemistry. radioactive wastes treatment and disposal, analytical chemistry and nuclear safeguard techniques, isotopes, application of nuclear technique, radiation protection and environmental protection and others. New progress was made in proposing the China Experimental Fast Reactor (CEFR), China advanced research reactor (CARR) and Beijing radioactive nuclear Beam facility (BRNBF) which are the three major projects of CIAE

Physics of the Cosmos Program Annual Technology Report

Science.gov (United States)

Pham, Bruce Thai; Cardiff, Ann H.

2015-01-01

What's in this Report? What's New? This fifth Program Annual Technology Report (PATR) summarizes the Programs technology development activities for fiscal year (FY) 2015. The PATR serves four purposes.1. Summarize the technology gaps identified by the astrophysics community;2. Present the results of this years technology gap prioritization by the PCOS Technology Management Board (TMB);3. Report on newly funded PCOS Strategic Astrophysics Technology (SAT) projects; and4. Detail progress, current status, and activities planned for the coming year for all technologies supported by PCOS Supporting Research and Technology (SRT) funding in FY 2015. .

Annual coral bleaching and the long-term recovery capacity of coral.

Science.gov (United States)

Schoepf, Verena; Grottoli, Andréa G; Levas, Stephen J; Aschaffenburg, Matthew D; Baumann, Justin H; Matsui, Yohei; Warner, Mark E

2015-11-22

Mass bleaching events are predicted to occur annually later this century. Nevertheless, it remains unknown whether corals will be able to recover between annual bleaching events. Using a combined tank and field experiment, we simulated annual bleaching by exposing three Caribbean coral species (Porites divaricata, Porites astreoides and Orbicella faveolata) to elevated temperatures for 2.5 weeks in 2 consecutive years. The impact of annual bleaching stress on chlorophyll a, energy reserves, calcification, and tissue C and N isotopes was assessed immediately after the second bleaching and after both short- and long-term recovery on the reef (1.5 and 11 months, respectively). While P. divaricata and O. faveolata were able to recover from repeat bleaching within 1 year, P. astreoides experienced cumulative damage that prevented full recovery within this time frame, suggesting that repeat bleaching had diminished its recovery capacity. Specifically, P. astreoides was not able to recover protein and carbohydrate concentrations. As energy reserves promote bleaching resistance, failure to recover from annual bleaching within 1 year will likely result in the future demise of heat-sensitive coral species. © 2015 The Author(s).

Atomic Energy of Canada Limited 2007 annual financial report

International Nuclear Information System (INIS)

2007-01-01

This is the annual report of Atomic Energy of Canada Limited for the year ending March 31, 2007 and summarizes the financial activities of AECL during the period 2006-2007. The highlights for this period include increase in consolidated commercial revenue by 40%, progress on the Cernavoda reactor, increased investment in the safety and performance of the CANDU fleet and a memorandum of understanding with Natural Resources Canada to govern implementation of a five-year waste management and decommissioning plan.

CPPI : supporting a dialogue : 1997 annual review

International Nuclear Information System (INIS)

1998-01-01

An annual review of the Canadian Petroleum Products Institute (CPPI) for 1997 is presented. CPPI is an association of Canadian companies involved in the refining, distribution and marketing of petroleum products. Canada currently operates 19 refineries which processed an average of 1.6 million barrels of crude oil per day in 1997. Canada also has a vast pipeline network. CPPI's responsibilities include 1) establishing environmental policies, 2) establishing working relationships with governments to develop public policy, 3) developing guidelines for the safe handling of petroleum products, and 4) providing information about the petroleum industry to the public. The review presents a summary of industry highlights, including a discussion of efficiency improvements in refinery and retail site operations, the establishment of standards regarding sulphur and benzene in gasoline, commitment to a one per cent annual improvement of refinery energy intensity, progress in tracking information on air, land and water quality, and workplace safety. The controversy over the octane enhancing fuel additive MMT for transportation fuels was also reviewed. A corporate directory of member companies, and board of directors is also included. tabs., figs

KBS Annual Report 1983. Including summaries of technical reports issued during 1983

International Nuclear Information System (INIS)

1984-06-01

The purpose of the KBS Annual Report is to inform interested organizations and individuals of the research and development work performed by the division KBS within the Swedish Nuclear Fuel Supply Co (SKBF) on the handling, treatment and final storage of nuclear wastes in Sweden. The Annual Report normally contains a presentation of the legal and organizational situation followed by an account of the progress within different areas of the R and D-work. This account also includes indications of the activities planned for the future. At the end of the report the summaries of 76 technical reports and other publications issued during the year are listed in special appendices. (K.A.E.)

Annual Report 1992-1993

International Nuclear Information System (INIS)

1993-11-01

The Office of The Supervising Scientist (OSS) underwent several significant changes during 1992-1993. Thus, the Sydney office was relocated to Canberra, and by May 1993 all OSS operations outside of the Northern Territory were being carried out at that locality. The relocation provided an opportunity to review the staff structure and increase efficiency. The annual report describes in detail work being undertaken, both nationally and internationally in developing radiation protection concepts that are appropriate for uranium mining industry. The emphasis of OSS research program is oriented towards effects on the environment. The report also provides a summary of of the progress of all active projects of the Alligator Rivers Region Institute. Details of all published and unpublished papers as well as the financial statement for the OSS are included in Appendixes. 16 tabs.; 28 figs

Longitudinal follow-up study of smoking-induced emphysema progression in low-dose CT screening of lung cancer

Science.gov (United States)

Suzuki, H.; Matsuhiro, M.; Kawata, Y.; Niki, N.; Nakano, Y.; Ohmatsu, H.; Kusumoto, M.; Tsuchida, T.; Eguchi, K.; Kaneko, Masahiro; Moriyama, N.

2014-03-01

Chronic obstructive pulmonary disease is a major public health problem that is predicted to be third leading cause of death in 2030. Although spirometry is traditionally used to quantify emphysema progression, it is difficult to detect the loss of pulmonary function by emphysema in early stage, and to assess the susceptibility to smoking. This study presents quantification method of smoking-induced emphysema progression based on annual changes of low attenuation volume (LAV) by each lung lobe acquired from low-dose CT images in lung cancer screening. The method consists of three steps. First, lung lobes are segmented using extracted interlobar fissures by enhancement filter based on fourdimensional curvature. Second, LAV of each lung lobe is segmented. Finally, smoking-induced emphysema progression is assessed by statistical analysis of the annual changes represented by linear regression of LAV percentage in each lung lobe. This method was applied to 140 participants in lung cancer CT screening for six years. The results showed that LAV progressions of nonsmokers, past smokers, and current smokers are different in terms of pack-year and smoking cessation duration. This study demonstrates effectiveness in diagnosis and prognosis of early emphysema in lung cancer CT screening.

Annual progress report

International Nuclear Information System (INIS)

Simon, A.

1980-01-01

Research efforts were concentrated on two main topics. One was to obtain a fit between single-mode nonlinear saturation theory and experimental observations on the PR-6 mirror device. A model of this experiment yields good agreement between predictions of the time variation of the fluctuating potential level, the floating potential, the mode wavelength and mode frequency, and observations. The second topic concerned single-mode Landau damping. The previous results of O-Neil-Morales were confirmed, but in much simpler form with no multiple sums. No longer-time corrections of any significant size were uncovered

Annual progress report

International Nuclear Information System (INIS)

Simon, A.

1975-01-01

Considerable success has been achieved this year in research aimed at extending the asymptotic threshold nonlinear theory to plasmas governed by the Vlasov equation and in a group of linear studies concerned with drift instabilities in sheared magnetic fields. The nonlinear results are general and have been applied to the bump-on-tail instability and to the collisionless drift and the dissipative trapped electron instability in unsheared fields. The linear studies have dealt with the effects of resonant electrons, finite collisionality, finite-beta, neoclassical modifications and ion gyro-motion on trapped electron instabilities in sheared magnetic fields

Annual progress report

International Nuclear Information System (INIS)

Wattenberg, A.; Simmons, R.O.

1980-06-01

During the present year, a major effort was put into developing the Mark III detector to be used with the e + e - colliding beams at SPEAR. Data from previous experiments at Fermilab using both neutral and charged particle beams were analyzed, and an approximately seven-month run with the photon beam on hydrogen and deuterium targets was performed. Apparatus for the forthcoming series of experiments using a proton beam with the Chicago Cyclotron Facility at Fermilab was developed and built. The main motivation for all the above experiments was to study the production and decay of states containing charmed quarks. During the coming year a major effort will continue at SLAC with the completion of the Mark III detector and its use in taking initial data. It is anticipated that several years of data taking with the Mark III will be required to obtain a statistically significant number of events of interest. At Fermilab an experiment using a proton beam with the Chicago Cyclotron Facility and a neutron beam in the broad band neutral beam facility will be performed. The data from the previous photoproduction run will be analyzed. In future years at Fermilab, experiments will be performed at increasingly higher energies as they become available. One of the motivations is the possible production of the (weak) intermediate vector bosons by colliding proton and anti-proton beams. For this purpose, a detector for the colliding beams is being developed, as is the so-called FASTBUS system. The scope of the program is best summarized by listing major accomplishments during the present year and the major parts of the program for the coming year. Being administrative in nature, this report contains insignificant amounts of data

Annual progress report

Energy Technology Data Exchange (ETDEWEB)

Little, J. B.

1981-06-01

Emphasis during the past year has been on studies of the effects of potential promoting agents on radiation transformation, and of transformation by internal radionuclides emitting high LET radiation. We have also carried out a detailed investigation of the dosimetry of our alpha radiation source. Preliminary studies on the mechanisms of radiation transformation have been initiated as described in the previous proposal. Studies on promotion have focused on the effects of: (1) the endogenous steroid hormone 17-..beta..-estradiol; (2) the non-steroidal anti-inflammatory agent indomethacin; (3) the endogenous growth factor called Epidermal Growth Factor (EGF); and (4) Melittin, a stimulator of prostaglandins synthesis.

Annual progress report

International Nuclear Information System (INIS)

Little, J.B.

1981-01-01

Emphasis during the past year has been on studies of the effects of potential promoting agents on radiation transformation, and of transformation by internal radionuclides emitting high LET radiation. We have also carried out a detailed investigation of the dosimetry of our alpha radiation source. Preliminary studies on the mechanisms of radiation transformation have been initiated as described in the previous proposal. Studies on promotion have focused on the effects of: (1) the endogenous steroid hormone 17-β-estradiol; (2) the non-steroidal anti-inflammatory agent indomethacin; (3) the endogenous growth factor called Epidermal Growth Factor (EGF); and (4) Melittin, a stimulator of prostaglandins synthesis

Annual progress report

International Nuclear Information System (INIS)

Simon, A.

1979-01-01

The research topics covered include a study of the nonlinear behavior of the drift cyclotron loss-cone instability in mirror machines and a study of the longer time behavior of the nonlinear O'Neil trapped particle saturation. The saturation amplitude for a single dominant mode near the stability onset boundary was determined for the drift cyclotron loss-cone instability for a variety of mirror-like distributions. The results are in good agreement with computer simulation studies of Cohen and Maron

Environmental Sciences Division annual progress report for period ending September 30, 1992

Energy Technology Data Exchange (ETDEWEB)

Van Hook, R. I.; Hildebrand, S. G.; Gehrs, C. W.; Sharples, F. E.; Shriner, D. S.; Stow, S. H.; Cushman, J. H.; Kanciruk, P.

1993-04-01

This progress report summarizes the research and development activities conducted in the Environmental Sciences Division of Oak Ridge National Laboratory during fiscal year (FY) 1992, which which extended from October 1, 1991, through September 30, 1992. This report is structured to provide descriptions of current activities and accomplishments in each of the division's major organizational units. Section activities are described in the Earth and Atmospheric sciences, ecosystem studies, Environmental analysis, environmental biotechnology, and division operations.

AR-v7 protein expression is regulated by protein kinase and phosphatase

Science.gov (United States)

Li, Yinan; Xie, Ning; Gleave, Martin E.; Rennie, Paul S.; Dong, Xuesen

2015-01-01

Failure of androgen-targeted therapy and progression of castration-resistant prostate cancer (CRPC) are often attributed to sustained expression of the androgen receptor (AR) and its major splice variant, AR-v7. Although the new generation of anti-androgens such as enzalutamide effectively inhibits AR activity, accumulating pre-clinical and clinical evidence indicates that AR-v7 remains constitutively active in driving CRPC progression. However, molecular mechanisms which control AR-v7 protein expression remain unclear. We apply multiple prostate cancer cell models to demonstrate that enzalutamide induces differential activation of protein phosphatase-1 (PP-1) and Akt kinase depending on the gene context of cancer cells. The balance between PP-1 and Akt activation governs AR phosphorylation status and activation of the Mdm2 ubiquitin ligase. Mdm2 recognizes phosphorylated serine 213 of AR-v7, and induces AR-v7 ubiquitination and protein degradation. These findings highlight the decisive roles of PP-1 and Akt for AR-v7 protein expression and activities when AR is functionally blocked. PMID:26378044

Technical progress report. Private sector initiatives between the United States and Japan. January 1989 - December 1989; ANNUAL

International Nuclear Information System (INIS)

1990-01-01

This annual report for calendar year 1989 describes the efforts performed under the Private Sector Initiatives contract. The report also describes those efforts that have continued with private funding after being initiated under this contract

Technical progress report. Private sector initiatives between the United States and Japan. January 1991 - December 1991; ANNUAL

International Nuclear Information System (INIS)

1993-01-01

This annual report for calendar year 1991 describes the efforts performed under the Private Sector Initiatives contract. The report also describes those efforts that have continued with private funding after being initiated under this contract

Environmental Sciences Division annual progress report for period ending September 30, 1991

Energy Technology Data Exchange (ETDEWEB)

1992-04-01

This progress report summarizes the research and development activities conducted in the Environmental Sciences Division of Oak Ridge National Laboratory during the period October 1, 1990, through September 30, 1991. The report is structured to provide descriptions of current activities and accomplishments in each of the division's major organizational units. Following the sections describing the organizational units is a section devoted to lists of information necessary to convey the scope of the work in the division. The Environmental Sciences Division (ESD) at Oak Ridge National Laboratory (ORNL) conducts environmental research and analyses associated with both energy technology development and the interactions between people and the environment. The division engages in basic and applied research for a diverse list of sponsors. While the US Department of Energy (DOE) is the primary sponsor ESD staff also perform research for other federal agencies, state agencies, and private industry. The division works collaboratively with federal agencies, universities, and private organizations in achieving its research objectives and hosts a large number of visiting investigators from these organizations. Given the diverse interdisciplinary specialization of its staff, ESD provides technical expertise on complex environmental problems and renders technical leadership for major environmental issues of national and local concern. This progress report highlights many of ESD's accomplishment in these and other areas in FY 1991.