Approaches and Methods of Periodization in Literary History

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Naser Gholi Sarli

2013-10-01

Full Text Available Abstract One of the most fundamental acts of historiography is to classify historical information in diachronic axis. The method of this classification or periodization shows the theoretical approach of the historian and determines the structure and the form of his history. Because of multiple criteria of analysis and various literary genres, periodization in literary history is more complicated than that of general history. We can distinguish two approaches in periodization of literary history, although these can be used together: extrinsic or social-cultural approach (based on criteria extrinsic to literature and intrinsic or formalist approach (based on criteria intrinsic to literature. Then periodization in literary history can be formulated in different methods and may be based upon various criteria: chronological such as century, decade and year organic patterns of evolution great poets and writers literary emblems and evaluations of every period events, concepts and periods of general or political history analogy of literary history and history of ideas or history of arts approaches and styles of language dominant literary norms. These methods actually are used together and everyone has adequacy in special kind of literary history. In periodization of Persian contemporary literature, some methods and models current in periodization of poetry have been applied identically to periodization of prose. Periodization based upon century, decade and year is the simplest and most mechanical method but sometimes certain centuries in some countries have symbolic and stylistic meaning, and decades were used often for subdivisions of literary history, especially nowadays with fast rhythm of literary change. Periodization according to organic patterns of evolution equates the changes of literary history with the life phases of an organism, and offers an account of birth, mature and death (and sometimes re-birth of literary genres, but this method have

Approaches and Methods of Periodization in Literary History

Directory of Open Access Journals (Sweden)

Dr. N. Gh. Sarli

Full Text Available One of the most fundamental acts of historiography is to classify historical information in diachronic axis. The method of this classification or periodization shows the theoretical approach of the historian and determines the structure and the form of his history. Because of multiple criteria of analysis and various literary genres, periodization in literary history is more complicated than that of general history. We can distinguish two approaches in periodization of literary history, although these can be used together: extrinsic or social-cultural approach (based on criteria extrinsic to literature and intrinsic or formalist approach (based on criteria intrinsic to literature. Then periodization in literary history can be formulated in different methods and may be based upon various criteria: chronological such as century, decade and year; organic patterns of evolution; great poets and writers; literary emblems and evaluations of every period; events, concepts and periods of general or political history; analogy of literary history and history of ideas or history of arts; approaches and styles of language; dominant literary norms. These methods actually are used together and everyone has adequacy in special kind of literary history. In periodization of Persian contemporary literature, some methods and models current in periodization of poetry have been applied identically to periodization of prose. Periodization based upon century, decade and year is the simplest and most mechanical method but sometimes certain centuries in some countries have symbolic and stylistic meaning, and decades were used often for subdivisions of literary history, especially nowadays with fast rhythm of literary change.Periodization according to organic patterns of evolution equates the changes of literary history with the life phases of an organism, and offers an account of birth, mature and death (and sometimes re-birth of literary genres, but this method have

Approaches and Methods of Periodization in Literary History

Directory of Open Access Journals (Sweden)

Naser Gholi Sarli

2013-11-01

Full Text Available Abstract One of the most fundamental acts of historiography is to classify historical information in diachronic axis. The method of this classification or periodization shows the theoretical approach of the historian and determines the structure and the form of his history. Because of multiple criteria of analysis and various literary genres, periodization in literary history is more complicated than that of general history. We can distinguish two approaches in periodization of literary history, although these can be used together: extrinsic or social-cultural approach (based on criteria extrinsic to literature and intrinsic or formalist approach (based on criteria intrinsic to literature. Then periodization in literary history can be formulated in different methods and may be based upon various criteria: chronological such as century, decade and year organic patterns of evolution great poets and writers literary emblems and evaluations of every period events, concepts and periods of general or political history analogy of literary history and history of ideas or history of arts approaches and styles of language dominant literary norms. These methods actually are used together and everyone has adequacy in special kind of literary history. In periodization of Persian contemporary literature, some methods and models current in periodization of poetry have been applied identically to periodization of prose. Periodization based upon century, decade and year is the simplest and most mechanical method but sometimes certain centuries in some countries have symbolic and stylistic meaning, and decades were used often for subdivisions of literary history, especially nowadays with fast rhythm of literary change. Periodization according to organic patterns of evolution equates the changes of literary history with the life phases of an organism, and offers an account of birth, mature and death (and sometimes re-birth of literary genres, but this method have

An Introduction to Literary Quaranic Stylistics

Science.gov (United States)

Almenoar, Lubna

2010-01-01

A stylistic analysis is one approach of analyzing a literary text using literary descriptions. The use of literary texts in the literature classroom has been limited to mostly Western sources. This paper is an attempt to create an awareness of the linguistic features present in the English language translations of the meaning of the Quran. The…

Effect of postradiation bleeding on proliferative activity of cells in small intestine crypts of rats

Energy Technology Data Exchange (ETDEWEB)

Petrovic, N V [Institut za Nuklearne Nauke Boris Kidric, Vinca (Yugoslavia)

1975-12-01

The effect of postradiation bleeding on the dynamics of duodenal crypt's cell proliferation in rats was studied. The animals, females, three months old, weighing 170 or 180 g, were exposed to radiation of 800 R (115 R/min) and immediately after irradiation were bled by cardiac puncture to 50% of total blood volume. Proliferative activity of duodenal epithelium cells was monitored for a period of five days after irradiation. For control purposes normal, irradiated and only bled animals were used. The results demonstrated that although there are no significant differences in proliferative activity of duodenal epithelium cells in irradiated and bled animals and only irradiated animals, the postradiation reparative processes in irradiated and bled animals is considerably more stable. It is considered that bleeding itself by its hypoxic activity reduced the sensitivity of epithelium to the dose of radiation used. On the other hand, bleeding removed the damaging agents which appear after total body irradiation.

Triterpenoid Saponins from Anemone rivularis var. Flore-Minore and Their Anti-Proliferative Activity on HSC-T6 Cells.

Science.gov (United States)

Wang, Xiao-Yang; Gao, Hui; Xie, Xiao-Jie; Jurhiin, Jirimubatu; Zhang, Mu-Zi-He; Zhou, Yan-Ping; Liu, Rui; Ning, Meng; Han, Jin; Tang, Hai-Feng

2018-02-23

Five previously undescribed triterpenoid saponins ( 1 - 5 ), along with eight known ones ( 6 - 13 ), were isolated from the whole plants of Anemone rivularis var. flore-minore . Their structures were clarified by extensive spectroscopic data and chemical evidence. For the first time, the lupane-type saponins ( 3 and 12 ) were reported from the Anemone genus. The anti-proliferative activity of all isolated saponins was evaluated on hepatic stellate cells (HSC-T6). Saponins 12 and 13 , which possess more monosaccharides than the others, displayed potent anti-proliferative activity, with IC 50 values of 18.21 and 15.56 μM, respectively.

Lifespan extension by preserving proliferative homeostasis in Drosophila.

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Benoît Biteau

2010-10-01

Full Text Available Regenerative processes are critical to maintain tissue homeostasis in high-turnover tissues. At the same time, proliferation of stem and progenitor cells has to be carefully controlled to prevent hyper-proliferative diseases. Mechanisms that ensure this balance, thus promoting proliferative homeostasis, are expected to be critical for longevity in metazoans. The intestinal epithelium of Drosophila provides an accessible model in which to test this prediction. In aging flies, the intestinal epithelium degenerates due to over-proliferation of intestinal stem cells (ISCs and mis-differentiation of ISC daughter cells, resulting in intestinal dysplasia. Here we show that conditions that impair tissue renewal lead to lifespan shortening, whereas genetic manipulations that improve proliferative homeostasis extend lifespan. These include reduced Insulin/IGF or Jun-N-terminal Kinase (JNK signaling activities, as well as over-expression of stress-protective genes in somatic stem cell lineages. Interestingly, proliferative activity in aging intestinal epithelia correlates with longevity over a range of genotypes, with maximal lifespan when intestinal proliferation is reduced but not completely inhibited. Our results highlight the importance of the balance between regenerative processes and strategies to prevent hyperproliferative disorders and demonstrate that promoting proliferative homeostasis in aging metazoans is a viable strategy to extend lifespan.

Epithelial cell proliferative activity of Barrett's esophagus : methodology and correlation with traditional cancer risk markers

NARCIS (Netherlands)

Peters, FTM; Ganesh, S; Kuipers, EJ; De Jager-Krikken, A; Karrenbeld, A; Harms, Geert; Sluiter, WJ; Koudstaal, J; Klinkenberg-Knol, EC; Lamers, CBHW; Kleibeuker, JH

Barrett's esophagus (BE) is a premalignant condition, due to chronic gastroesophageal reflux. Effective antireflux therapy may diminish cancer risk. To evaluate this option an intermediate marker is needed. We developed a methodology for measurement of epithelial cell proliferative activity of

Literary Language in Development of L2 Competence

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Dan Lu

2012-11-01

Full Text Available Nowadays it is believed that language in daily communication rather than literary language should be the target of learning in L2 education. This is mainly because literary language is said to be uncommon in life. This paper reports on a study in which some Hong Kong ESL learners’ English proficiency was re-examined through literary texts. These learners had reached intermediate or advanced levels of English prior to the study and were generally competent in daily English. However, many of them encountered difficulty in understanding literary language. Their proficiency in general English test could not match their performances in understanding literary works. The findings reveal that learners who are strong in general proficiency may not be good in understanding literary language. Lack of literary language in the curriculum results in a false and distorted picture about the learners’ proficiency. Literary language helps upgrade L2 learners’ real proficiency in the target language.

Reader responses to literary depictions of rape

NARCIS (Netherlands)

E.M. Koopman (Emy); M. Hilscher (Michelle); G.C. Cupchik (Gerald)

2012-01-01

textabstractThis study explored reader responses to different literary depictions of rape. Four literary excerpts were used and divided as aesthetic versus nonaesthetic (style) and allusive versus explicit (detail). The general question was how readers would react to literary fragments depicting

Proliferative capacity of murine hematopoietic stem cells

International Nuclear Information System (INIS)

Hellman, S.; Botnick, L.E.; Hannon, E.C.; Vigneulle, R.M.

1978-01-01

The present study demonstrates a decrease in self-renewal capacity with serial transfer of murine hematopoietic stem cells. Production of differentiated cell progeny is maintained longer than stem cell self-renewal. In normal animals the capacity for self-renewal is not decreased with increasing donor age. The stem cell compartment in normal animals, both young and old, appears to be proliferatively quiescent. After apparent recovery from the alkylating agent busulfan, the probability of stem cell self-renewal is decreased, there is a permanent defect in the capacity of the bone marrow for serial transplantation, and the stem cells are proliferatively active. These findings support a model of the hematopoietic stem cell compartment as a continuum of cells with decreasing capacities for self-renewal, increasing likelihood for differentiation, and increasing proliferative activity. Cells progress in the continuum in one direction and such progression is not reversible

THE BIOTIC FACTOR OF TREMATOD OPISTHORHIS FELINEUS INVASION INFLUENCE ON HOST IMMUNE STATUS AND SOMATIC CELLS PROLIFERATIVE ACTIVITY

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A. G. Rybka

2016-01-01

Full Text Available The paper confirms long-time opisthorhis invasion role as a risk factor of host immune system reconstitution as well as an important factor in holangiocarcinomas development. It was shown that opisthorhosis invasion primal stage induce host immune system reconstitution. Host immune B-cells system is activated by metacercaria antigens, while the same antigens inhibits T-cells activity. Opisthorhis metabolites stimulate proliferative mithogen-induced T-cells acti vity. Chronic opisthorchis invasion leads to immune system disbalance. It means: decrease of specific and non-speci fic natural killers activity, number of high proliferative activity T-lymphocytes and the shift of regulatory T-cells subset to suppressors prevalence. At the same time specific as well as non-specific T-suppressors functional ability is very low. It was shown T-cells helper-amplifier activation. Despite of circulating B-cells decrease the antibody produced cells number is spleen increases significantly at the same time with circulating immune complexes accumulation. Even 3–6 month after dehelmintisation the immune system disbalance decreases but lefts. In addition, chronic opisthorhis invasion leads to the proliferative processes activation in ductal epithelium, liver, lymph nodes and in other organs which leads to cancer proliferation. According to the results obtained the opisthorhis infected patients needs to be immunocorrected before as well as after dehelmintisation for holangiocancerogenesis profylaxis.

Intersections : Amazigh (Berber) Literary Space

NARCIS (Netherlands)

Merolla, D.; Bratt, K. R.; Elbousty, Y.; Steward, D.J.

2014-01-01

The interaction of artistic productions with several languages, literary markets and media is crucial in the Amazigh literary space. Focusing on writers who use the Amazigh (Berber) language, this study addresses contemporary directions in Moroccan Amazigh (Berber) artistic works set against the

In vitro anti-proliferative activity on colon cancer cell line (HT-29) of Thai medicinal plants selected from Thai/Lanna medicinal plant recipe database "MANOSROI III".

Science.gov (United States)

Manosroi, Aranya; Akazawa, Hiroyuki; Akihisa, Toshihiro; Jantrawut, Pensak; Kitdamrongtham, Worapong; Manosroi, Worapaka; Manosroi, Jiradej

2015-02-23

Thai/Lanna region has its own folklore wisdoms including the traditional medicinal plant recipes. Thai/Lanna medicinal plant recipe database "MANOSROI III" has been developed by Prof. Dr. Jiradej Manosroi. It consists of over 200,000 recipes for all diseases including cancer. To investigate the anti-proliferative and apoptotic activities on human colon cancer cell line (HT-29) as well as the cancer cell selectivity of the methanolic extracts (MEs) and fractions of the 23 selected plants from the "MANOSROI III" database. The 23 selected plants were extracted with methanol under reflux and evaluated for their anti-proliferative activity by sulforhodamine B assay. The 5 plants (Gloriosa superba, Caesalpinia sappan, Fibraurea tinctoria, Ventilago denticulata and Psophocarpus tetragonolobus) with potent anti-proliferative activity were fractionated by liquid-liquid partition to give 4 fractions including each hexane (HF), methanol-water (MF), n-butanol (BF) and water (WF) fractions. They were tested for anti-proliferative activity and cancer cell selectivity. The ME and fractions of G. superba which showed potent anti-proliferative activity were further examined for morphological changes and apoptotic activities by acridine orange (AO)/ethidium bromide (EB) staining. The ME of G. superba root showed active with the highest anti-proliferative activity at 9.17 and 1.58 folds of cisplatin and doxorubicin, respectively. After liquid-liquid partition, HF of V. denticulata, MFs of F. tinctoria, V. denticulata and BF of P. tetragonolobus showed higher anti-proliferative activities than their MEs. The MF of G. superba indicated the highest anti-proliferative activity at 7.73 and 1.34 folds of cisplatin and doxorubicin, respectively, but only 0.86 fold of its ME. The ME and HF, MF and BF of G. superba and MF of F. tinctoria demonstrated high cancer cell selectivity. At 50 µg/ml, ME, HF, MF and BF of G. superba demonstrated higher apoptotic activities than the two standard drugs

Proliferative and anti-proliferative effects of dietary levels of phytoestrogens in rat pituitary GH3/B6/F10 cells - the involvement of rapidly activated kinases and caspases

International Nuclear Information System (INIS)

Jeng, Yow-Jiun; Watson, Cheryl S

2009-01-01

Phytoestogens are a group of lipophillic plant compounds that can have estrogenic effects in animals; both tumorigenic and anti-tumorigenic effects have been reported. Prolactin-secreting adenomas are the most prevalent form of pituitary tumors in humans and have been linked to estrogen exposures. We examined the proliferative effects of phytoestrogens on a rat pituitary tumor cell line, GH 3 /B 6 /F 10 , originally subcloned from GH 3 cells based on its ability to express high levels of the membrane estrogen receptor-α. We measured the proliferative effects of these phytoestrogens using crystal violet staining, the activation of several mitogen-activated protein kinases (MAPKs) and their downstream targets via a quantitative plate immunoassay, and caspase enzymatic activities. Four phytoestrogens (coumestrol, daidzein, genistein, and trans-resveratrol) were studied over wide concentration ranges. Except trans-resveratrol, all phytoestrogens increased GH 3 /B 6 /F 10 cell proliferation at some concentration relevant to dietary levels. All four phytoestrogens attenuated the proliferative effects of estradiol when administered simultaneously. All phytoestrogens elicited MAPK and downstream target activations, but with time course patterns that often differed from that of estradiol and each other. Using selective antagonists, we determined that MAPKs play a role in the ability of these phytoestrogens to elicit these responses. In addition, except for trans-resveratrol, a serum removal-induced extrinsic apoptotic pathway was blocked by these phytoestrogens. Phytoestrogens can block physiological estrogen-induced tumor cell growth in vitro and can also stimulate growth at high dietary concentrations in the absence of endogenous estrogens; these actions are correlated with slightly different signaling response patterns. Consumption of these compounds should be considered in strategies to control endocrine tumor cell growth, such as in the pituitary

Technology Toolkit: Literary Road Trip

Science.gov (United States)

Hayes, Sandy

2007-01-01

Hayes recognizes the value of connections kids make when authors and settings strike a familiar note. She invites readers to participate in a new event at this year's NCTE Annual Convention in New York City: The 21st-Century Literary Map Project gallery, where attendees are encouraged to examine affiliates' literary maps, see digital or…

Synthesis, characterization, in vitro anti-proliferative and hemolytic activity of hydroxyapatite

Science.gov (United States)

Palanivelu, R.; Ruban Kumar, A.

2014-06-01

Hydroxyapatite (Ca10(PO4)6(OH)2, HAP) nanoparticles are widely used in several biomedical applications due to its compositional similarities to bone mineral, excellent biocompatibility and bioactivity, osteoconductivity. In this present investigation, HAP nanoparticles synthesized by precipitation technique using calcium nitrate and di-ammonium phosphate. The crystalline nature and the functional group analysis are confirmed using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and Fourier transform Raman spectroscopy (FT-Raman) respectively. The morphological observations are ascertained from field emission electron scanning electron microscope (FE-SEM) and transmission electron microscope (TEM). In vitro anti-proliferative and hemolytic activities are carried out on the synthesized HAP samples and the studies reveals that HAP have mild activity against erythrocytes.

NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy.

Science.gov (United States)

Loukovaara, Sirpa; Piippo, Niina; Kinnunen, Kati; Hytti, Maria; Kaarniranta, Kai; Kauppinen, Anu

2017-12-01

Innate immunity and dysregulation of inflammatory processes play a role in vascular diseases like atherosclerosis or diabetes. Nucleotide-binding domain and Leucine-rich repeat Receptor containing a Pyrin domain 3 (NLRP3) inflammasomes are pro-inflammatory signalling complexes that were found in 2002. In addition to pathogens and other extracellular threats, they can be activated by various endogenous danger signals. The purpose of this study was to find out whether NLRP3 activation occurs in patients with sight-threatening forms of diabetic retinopathy (DR). Inflammasome components NLRP3 and caspase-1, inflammasome-related pro-inflammatory cytokines IL-1β and IL-18, vascular endothelial growth factor (VEGF), acute-phase cytokines TNF-α and IL-6, as well as adaptive immunity-related cytokine interferon gamma (IFN-γ) were measured from the vitreous samples of 15 non-proliferative diabetic retinopathy (non-PDR) and 23 proliferative diabetic retinopathy (PDR) patients using the enzyme-linked immunosorbent assay (ELISA) method. The adaptor protein apoptosis-associated speck-like protein containing a CARD (ASC) was determined using the Western blot technique. Inflammasome components were present in the vitreous of DR patients. Along with VEGF, the levels of caspase-1 and IL-18 were significantly increased, especially in PDR eyes. Interestingly, clearly higher levels of NLRP3 were found in the PDR eyes with tractional retinal detachment (TRD) than from PDR eyes with fully attached retina. There were no significant differences in the amounts of IL-1β, TNF-α, IL-6, and IFN-γ that were detectable in the vitreous of both non-PDR and PDR patients. Our results suggest that NLRP3 inflammasome activation can be associated especially with the pathogenesis of PDR. The lack of differences in TNF-α, IL-6, and IFN-γ also alludes that acute inflammation or T-cell-mediated responses do not dominate in PDR pathogenesis. © 2017 Acta Ophthalmologica Scandinavica Foundation

Hyper-activation of Notch3 amplifies the proliferative potential of rhabdomyosarcoma cells.

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Maria De Salvo

Full Text Available Rhabdomyosarcoma (RMS is a pediatric myogenic-derived soft tissue sarcoma that includes two major histopathological subtypes: embryonal and alveolar. The majority of alveolar RMS expresses PAX3-FOXO1 fusion oncoprotein, associated with the worst prognosis. RMS cells show myogenic markers expression but are unable to terminally differentiate. The Notch signaling pathway is a master player during myogenesis, with Notch1 activation sustaining myoblast expansion and Notch3 activation inhibiting myoblast fusion and differentiation. Accordingly, Notch1 signaling is up-regulated and activated in embryonal RMS samples and supports the proliferation of tumor cells. However, it is unable to control their differentiation properties. We previously reported that Notch3 is activated in RMS cell lines, of both alveolar and embryonal subtype, and acts by inhibiting differentiation. Moreover, Notch3 depletion reduces PAX3-FOXO1 alveolar RMS tumor growth in vivo. However, whether Notch3 activation also sustains the proliferation of RMS cells remained unclear. To address this question, we forced the expression of the activated form of Notch3, Notch3IC, in the RH30 and RH41 PAX3-FOXO1-positive alveolar and in the RD embryonal RMS cell lines and studied the proliferation of these cells. We show that, in all three cell lines tested, Notch3IC over-expression stimulates in vitro cell proliferation and prevents the effects of pharmacological Notch inhibition. Furthermore, Notch3IC further increases RH30 cell growth in vivo. Interestingly, knockdown of Notch canonical ligands JAG1 or DLL1 in RMS cell lines decreases Notch3 activity and reduces cell proliferation. Finally, the expression of Notch3IC and its target gene HES1 correlates with that of the proliferative marker Ki67 in a small cohort of primary PAX-FOXO1 alveolar RMS samples. These results strongly suggest that high levels of Notch3 activation increase the proliferative potential of RMS cells.

PECULIARITIES OF PROLIFERATIVE ACTIVITY OF CERVICAL SQUAMOUS CANCER IN HIV INFECTION.

Science.gov (United States)

Lytvynenko, M; Shkolnikov, V; Bocharova, T; Sychova, L; Gargin, V

2017-09-01

Patients with human immunodeficiency virus (HIV) infection have a statistically significant increased risk of developing cervical cancer. The expression of the human Ki-67 protein is strictly associated with cell proliferation. The purpose of our work was detection of proliferative activity in cervical squamous cancer in women with HIV infection. We investigated 24 cases (12 patients with HIV and 12 patients without HIV infection) of cervical carcinoma, where biopsy had been performed before the treatment. According to histopathological diagnoses, well-differentiated, moderately and poorly differentiated squamous cell carcinoma (7, 13 and 4 cases respectively) was determined. Mean age of women in the group with HIV infection was 32.7 years, and 38.2 years in the group without HIV infection. Detection of protein Ki-67 expression was performed with nuclear staining in the intermediate and superficial cells. The results of this work show that proliferative activity of cervical squamous cancer in women with HIV infection is characterized by a higher level of Ki-67 with averaging level for all histological types of squamous cell carcinoma 62.5±5.6% that is one and half times higher than in group without HIV infection. Depending on a histological type, expression of Ki-67 has increased from 4.7±3.8% in well-differentiated squamous cell carcinoma up to 89.2±5.1% in poorly differentiated squamous cell carcinoma for group with HIV, and from 21.3±2.4% to 79.4±3.7 in group without HIV.

Cytological Study of Breast Carcinoma Before and After Oncotherapy with Special Reference to Morphometry and Proliferative Activity.

Science.gov (United States)

Koley, Sananda; Chakrabarti, Srabani; Pathak, Swapan; Manna, Asim Kumar; Basu, Siddhartha

2015-12-01

Our study was done to assess the cytological changes due to oncotherapy in breast carcinoma especially on morphometry and proliferative activity. Cytological aspirates were collected from a total of 32 cases of invasive ductal carcinoma both before and after oncotherapy. Morphometry was done on the stained cytological smears to assess the different morphological parameters of cell dimension by using the ocular morphometer and the software AutoCAD 2007. Staining was done with Ki-67 and proliferating cell nuclear antigen (PCNA) as proliferative markers. Different morphological parameters were compared before and after oncotherapy by unpaired Student's t test. Statistically significant differences were found in morphometric parameters, e.g., mean nuclear diameter, mean nuclear area, mean cell diameter, and mean cell area, and in the expression of proliferative markers (Ki-67 and PCNA). Statistical analysis was done by obtaining p values. There are statistically significant differences between morphological parameter of breast carcinoma cells before and after oncotherapy.

Classification of authors by literary prestige

NARCIS (Netherlands)

Verboord, Marc

2003-01-01

In this study, I investigated a new system to classify authors by literary prestige. The notion of ‘canon’ was considered to lackclear theoretical and empirical grounding. Evaluation and classification practices were examined and operationalized from the perspective of literary field theory. The

Linguistic Levels of Translation: A Generic Exploration of Translation Difficulties in Literary Textual Corpus

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Magda Madkour

2016-11-01

Full Text Available This case study research was based on a generic exploration of the translation problems that graduate students face in literary translation. Literary translation is fundamental to translation programs at higher education due to the upsurge that has occurred in publishing classical and modern literary works from various cultures. However, literary texts have special characteristics that make the process of transferring them from one language into another a daunting task. Translating literary texts is difficult even for professional translators because misinterpreting the messages of the source texts can lead to distorting the aesthetic aspects of the literary work. Students need to learn various linguistic levels of literary translation as well as strategies and methods of translation. Learning the linguistics levels of translation necessitates providing adequate training that is based on enhancing students’ cognitive abilities. Cognitive-based translation training helps students learn the procedures of solving the problems of translating sound and literary devices. Cognitive approaches are relevant to the translation process since cognition implies mental activities that students can use to understand and synthesize the literary text, and reconstruct it creatively. Therefore, the current study aimed at examining the relationship between cognitive teaching methodologies and students’ performance in literary translation. To examine this relationship, qualitative and quantitative data was collected from graduate students at the College of Languages and Translation at Imam Mohammed bin Saud Islamic University (IMAMU University, Riyadh, Saudi Arabia. In addition, corpus data was gathered from authentic literary texts including, novels, short stories, and poetry, to investigate the effect of linguistic analysis and cognitive strategies on the quality of literary translation. Quantitative data was analyzed using the Statistical Package for the

Evaluation of viability and proliferative activity of human urothelial cells cultured onto xenogenic tissue-engineered extracellular matrices.

LENUS (Irish Health Repository)

Davis, Niall F

2011-04-01

To evaluate the viability and proliferative activity of human urothelial cells (HUCs) cultured on tissue-engineered extracellular matrix scaffolds and to assess the potential of extracellular matrixes to support the growth of HUCs in their expected in vivo urine environment.

In vitro anti-proliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb

Czech Academy of Sciences Publication Activity Database

Landa, Přemysl; Skálová, L.; Boušová, I.; Kutil, Zsófia; Langhansová, Lenka; Lou, J.D.; Vaněk, Tomáš

2014-01-01

Roč. 27, č. 1 (2014), s. 103-106 ISSN 1011-601X R&D Projects: GA MŠk ME08070 Institutional support: RVO:61389030 Keywords : anti-proliferative activity * anti-inflammatory activity * breast cancer Subject RIV: EI - Biotechnology ; Bionics Impact factor: 0.682, year: 2014 http://www.pjps.pk/wp-content/uploads/pdfs/27/1/Paper-15.pdf

Literary Magazines: To Censor or Not?

Science.gov (United States)

Mossman, Robert C.

2007-01-01

High school teacher Robert C. Mossman asserts that literary magazines reflect and elevate school communities' values. As adviser of his school literary magazine, Mossman encourages students to uphold certain standards for decency, while helping students learn to distinguish between original writing that is specific and thoughtful and writing that…

GTP depletion synergizes the anti-proliferative activity of chemotherapeutic agents in a cell type-dependent manner

International Nuclear Information System (INIS)

Lin, Tao; Meng, Lingjun; Tsai, Robert Y.L.

2011-01-01

Highlights: → Strong synergy between mycophenolic acid (MPA) and 5-FU in MDA-MB-231 cells. → Cell type-dependent synergy between MPA and anti-proliferative agents. → The synergy of MPA on 5-FU is recapitulated by RNA polymerase-I inhibition. → The synergy of MPA on 5-FU requires the expression of nucleostemin. -- Abstract: Mycophenolic acid (MPA) depletes intracellular GTP by blocking de novo guanine nucleotide synthesis. GTP is used ubiquitously for DNA/RNA synthesis and as a signaling molecule. Here, we made a surprising discovery that the anti-proliferative activity of MPA acts synergistically with specific chemotherapeutic agents in a cell type-dependent manner. In MDA-MB-231 cells, MPA shows an extremely potent synergy with 5-FU but not with doxorubicin or etoposide. The synergy between 5-FU and MPA works most effectively against the highly tumorigenic mammary tumor cells compared to the less tumorigenic ones, and does not work in the non-breast cancer cell types that we tested, with the exception of PC3 cells. On the contrary, MPA shows the highest synergy with paclitaxel but not with 5-FU in SCC-25 cells, derived from oral squamous cell carcinomas. Mechanistically, the synergistic effect of MPA on 5-FU in MDA-MB-231 cells can be recapitulated by inhibiting the RNA polymerase-I activity and requires the expression of nucleostemin. This work reveals that the synergy between MPA and anti-proliferative agents is determined by cell type-dependent factors.

Nonconformist discourse of literary criticism activity of Mykhailyna Kotsiubynska

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Светлана Григорьевна Бугай

2015-05-01

Full Text Available The peculiarity of scientific and critical reception of history and theory of Ukrainian literature in studios of Mykhaylyna Kotsiubynska is considered in the article. It is given the detailed analysis of scientific approaches and attitudes in literary interpretation of the key issues of artistic discourse: features of genre-thematic, compositional structure, imagery and stylistic palette of writing, specific of writer’s artistic thinking, ethical and philosophical foundations of creativity, originality of associative relationships, understanding artistic heritage in the context of the time

Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa

Science.gov (United States)

Yue, Grace G. L.; Chan, Ben C. L.; Hon, Po-Ming; Lee, Mavis Y. H.; Fung, Kwok-Pui; Leung, Ping-Chung; Lau, Clara B. S.

2010-01-01

The rhizome of Curcuma longa (CL) has been commonly used in Asia as a potential candidate for the treatment of different diseases, including inflammatory disorders and cancers. The present study evaluated the anti-proliferative activities of the isolated compounds (3 curcuminoids and 2 turmerones) from CL, using human cancer cell lines HepG2, MCF-7 and MDA-MB-231. The immunomodulatory activities of turmerones (α and aromatic) isolated from CL were also examined using human peripheral blood mononuclear cells (PBMC). Our results showed that the curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) and α-turmerone significantly inhibited proliferation of cancer cells in dose-dependent manner. The IC50 values of these compounds in cancer cells ranged from 11.0–41.8 μg/ml. Alpha-turmerone induced MDA-MB-231 cells to undergo apoptosis, which was confirmed by annexin-V & propidium iodide staining, and DNA fragmentation assay. The caspase cascade was activated as shown by a significant decrease of procaspases-3, -8 and -9 in α-turmerone treated cells. Both α-turmerone and aromatic-turmerone showed stimulatory effects on PBMC proliferation and cytokine production. The anti-proliferative effect of α-turmerone and immunomodulatory activities of ar-turmerone were shown for the first time. The findings revealed the potential use of CL crude extract (containing curcuminoids and volatile oil including turmerones) as chemopreventive agent. PMID:20438793

Proliferative activity and branching morphogenesis in the human prostate: a closer look at pre- and postnatal prostate growth

NARCIS (Netherlands)

Xue, Y.; Sonke, G.; Schoots, C.; Schalken, J.; Verhofstad, A.; de la Rosette, J.; Smedts, F.

2001-01-01

To gain further insight into the molecular cell biologic features of prostate development, we investigated the proliferative activity of prostate epithelial and stromal cells and their topographic relationship with neuroendocrine (NE) cell distribution and regional heterogeneity. Consecutive

Proliferative activity and branching morphogenesis in the human prostate: a closer look at pre- and postnatal prostate growth.

NARCIS (Netherlands)

Xue, Y.; Sonke, G.S.; Schoots, C.; Schalken, J.A.; Verhofstad, A.A.J.; Rosette, J.J.M.H.C. de la; Smedts, F.

2001-01-01

BACKGROUND: To gain further insight into the molecular cell biologic features of prostate development, we investigated the proliferative activity of prostate epithelial and stromal cells and their topographic relationship with neuroendocrine (NE) cell distribution and regional heterogeneity.

Curcumin Conjugated with PLGA Potentiates Sustainability, Anti-Proliferative Activity and Apoptosis in Human Colon Carcinoma Cells

Science.gov (United States)

Waghela, Bhargav N.; Sharma, Anupama; Dhumale, Suhashini; Pandey, Shashibahl M.; Pathak, Chandramani

2015-01-01

Curcumin, an ingredient of turmeric, exhibits a variety of biological activities such as anti-inflammatory, anti-atherosclerotic, anti-proliferative, anti-oxidant, anti-cancer and anti-metastatic. It is a highly pleiotropic molecule that inhibits cell proliferation and induces apoptosis in cancer cells. Despite its imperative biological activities, chemical instability, photo-instability and poor bioavailability limits its utilization as an effective therapeutic agent. Therefore, enhancing the bioavailability of curcumin may improve its therapeutic index for clinical setting. In the present study, we have conjugated curcumin with a biodegradable polymer Poly (D, L-lactic-co-glycolic acid) and evaluated its apoptotic potential in human colon carcinoma cells (HCT 116). The results show that curcumin-PLGA conjugate efficiently inhibits cell proliferation and cell survival in human colon carcinoma cells as compared to native curcumin. Additionally, curcumin conjugated with PLGA shows improved cellular uptake and exhibits controlled release at physiological pH as compared to native curcumin. The curcumin-PLGA conjugate efficiently activates the cascade of caspases and promotes intrinsic apoptotic signaling. Thus, the results suggest that conjugation potentiates the sustainability, anti-proliferative and apoptotic activity of curcumin. This approach could be a promising strategy to improve the therapeutic index of cancer therapy. PMID:25692854

Fascinating! Popular Science Communication and Literary Science Fiction

DEFF Research Database (Denmark)

Meyer, Gitte

2017-01-01

Some see literary Science Fiction as a possible vehicle for critical discussions about the future development and the ethical implications of science-based technologies. According to that understanding, literary Science Fiction constitutes a variety of science communication. Along related lines, ......, popular science communication with science fiction features might be expected to serve a similar purpose. Only, it is far from obvious that it actually works that way.......Some see literary Science Fiction as a possible vehicle for critical discussions about the future development and the ethical implications of science-based technologies. According to that understanding, literary Science Fiction constitutes a variety of science communication. Along related lines...

Quantitative criticism of literary relationships.

Science.gov (United States)

Dexter, Joseph P; Katz, Theodore; Tripuraneni, Nilesh; Dasgupta, Tathagata; Kannan, Ajay; Brofos, James A; Bonilla Lopez, Jorge A; Schroeder, Lea A; Casarez, Adriana; Rabinovich, Maxim; Haimson Lushkov, Ayelet; Chaudhuri, Pramit

2017-04-18

Authors often convey meaning by referring to or imitating prior works of literature, a process that creates complex networks of literary relationships ("intertextuality") and contributes to cultural evolution. In this paper, we use techniques from stylometry and machine learning to address subjective literary critical questions about Latin literature, a corpus marked by an extraordinary concentration of intertextuality. Our work, which we term "quantitative criticism," focuses on case studies involving two influential Roman authors, the playwright Seneca and the historian Livy. We find that four plays related to but distinct from Seneca's main writings are differentiated from the rest of the corpus by subtle but important stylistic features. We offer literary interpretations of the significance of these anomalies, providing quantitative data in support of hypotheses about the use of unusual formal features and the interplay between sound and meaning. The second part of the paper describes a machine-learning approach to the identification and analysis of citational material that Livy loosely appropriated from earlier sources. We extend our approach to map the stylistic topography of Latin prose, identifying the writings of Caesar and his near-contemporary Livy as an inflection point in the development of Latin prose style. In total, our results reflect the integration of computational and humanistic methods to investigate a diverse range of literary questions.

The Missing Hybridity: ‘Envisioning’ Ukrainian Literary Space

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Marco Puleri

2015-05-01

Full Text Available In this paper, the author focuses on the question concerning the complex positioning of the Russophone literary phenomenon in the Ukrainian post-Soviet literary canon. Analysing the conceptualization of the hybrid cultural elements in the post-Soviet cultural area, it is possible to observe the rise of a contrast between the cultural ‘exclusivist’ and ‘inclusivist’ attitudes in the Ukrainian literary debate. It is the product of the renewed social and political clash between the Ukrainian and Russian ‘national systems’. The ideologization of the ethnolinguistic factor in the Post-Soviet area gives birth to competing ideologies, which draw new ‘imagined borders’ in the Ukrainian literary space. It is the result of the polarization of the respective national historical narratives, misused by the current political discourses, to paralyse the dialogical perspectives in the process of cultural confrontation. Listening to the ‘voices’ of contemporary cultural actors, it will be possible to draw different images in order to envision the Ukrainian literary space.

Household Scribes and the Production of Literary Manuscripts in Early Modern England

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Marcy L. North

2015-03-01

Full Text Available In early modern English households, literate servants such as tutors, chaplains, stewards, secretaries, and ladies in waiting were well positioned to assist their employers in the assembly and copying of verse miscellanies, anthologies, and other literary manuscripts. Looking at several literary manuscripts, some with known servant contributions and others that suggest the participation of household retainers, the essay explores the likelihood that literate servants often performed scribal tasks above and beyond their formal job descriptions, even serving as scribe for their employers’ hobbies and leisure activities. Although copying was an arduous task, servants appear to have viewed these duties not simply as part of their job but also as gift exchanges, as appeals for promotion or patronage, and as a means by which they might gain access to manuscript literature and literary circles. Studies of early modern letter writing have called attention to many of the copy tasks of literate household servants, but the integral role of literate servants in the collection, copying, and preservation of literary manuscripts deserves much more attention.

Chromatographic analysis, anti-proliferative and radical scavenging activity of Pinus wallichina essential oil growing in high altitude areas of Kashmir, India.

Science.gov (United States)

Yousuf Dar, Mohd; Shah, Wajaht A; Mubashir, Sofi; Rather, Manzoor A

2012-10-15

To evaluate the in vitro anti-proliferative and radical scavenging properties of the essential oil and its fractions and to determine the chemo-type of P. wallichiana essential oil. Pinus wallichiana oil was extracted by hydro-distillation and fractionated by silica gel column chromatography method. The oil and its fractions were analyzed by Gas chromatography, Gas chromatography-mass spectrometry and (13)C NMR. Different concentrations of oil 12.5, 25, 50 and 100μg/ml and single concentration 50μg/ml of its fractions B(1), B(2), A(2), G(2), Uk(13) and I(2) were evaluated for its anti-proliferative activity by in vitro {3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide} assay against human monocyte, lung carcinoma, liver adenocarcinoma, prostate and ovarian carcinoma, while as the radical scavenging activity was evaluated by different in vitro DPPH assays. The analyses indicated the presence of 17 constituents with β-pinene (46.8%) and α-pinene (25.2%) as major constituents. The oil and its fractions showed significant anti-proliferative activity. The radical scavenging activity also showed good results. The oil could be used as a drug to control the diseases like cancer, cirrhosis and arteriosclerosis, caused by reactive oxygen species. Copyright © 2012 Elsevier GmbH. All rights reserved.

Literary and Electronic Hypertext: Borges, Criticism, Literary Research, and the Computer.

Science.gov (United States)

Davison, Ned J.

1991-01-01

Examines what "hypertext" means to literary criticism on the one hand (i.e., intertextuality) and computing on the other, to determine how the two concepts may serve each other in a mutually productive way. (GLR)

Finding Feminist Literary Reading: Portrayals Of Women In The 1920s Indonesian Literary Writings

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Diah Ariani Arimbi

2014-12-01

Full Text Available Abstract: Modern Indonesian literature can be said to be born around 1920s with the publication of modern Indonesian literary works by Balai Pustaka. Amongst the works published by Balai Pustaka in the 1920s ; there are most popular works namely Sitti Nurbaya (1922 ; Azab dan Sengsara(1927 and Salah Asuhan (1928 representing the tone of 1920s literary productions. This paper aims to look at images of women in those three works written by male authors ; using feminist literary criticism. By means of close reading technique; the study uses feminist literary criticism to examine and (reexamine the images of women portrayed in those three works. The finding shows that on one hand some women are still trapped with the shackle of patriarchy, but, on the other hand, some women are not simply passive victims of patriarchy: these women still attempt to escape from the patriarchal chain and cut out the patriarchal oppression. Key Words: modern Indonesian literature; 1920s; Balai Pustaka; women; feminist literary criticism Abstrak: Sastra Indonesia modern dapat dikatakan lahir sekitar tahun1920-an dengan publikasi karya sastra Indonesia modern oleh Balai Pustaka. Di antara karya yang diterbitkan oleh Balai Pustaka pada tahun 1920-an; terdapat karya yang paling populer seperti Sitti Nurbaya (1922; Azab dan Sengsara (1927; dan Salah Asuhan (1928 yang mewakili suara produksi sastra tahun 1920-an. Makalah ini bertujuan untuk melihat potret perempuan dalam tiga karya yang ditulis oleh penulis laki-laki dengan menggunakan pendekatan kritik sastra feminis. Melalui teknik pembacaan yang mendalam (close reading technique; penelitian ini menggunakan kritik sastra feminis untuk menelaah potret perempuan dalam tiga karya tersebut. Temuan dalam tulisan ini menunjukkan bahwa di satu sisi perempuan masih terbelenggu oleh patriarkat; tetapi di sisi lain perempuan bukanlah korban patriarkat yang pasif: perempuan tetap berupaya untuk keluar dari belenggu ini dan memutus

[Effect of low-intensity electromagnetic fields of industrial frequency on the ultrastructure and proliferative activity of rat's thymus cells].

Science.gov (United States)

Zhitkevich, T I; Bokut', T B; Netukova, N I

2001-01-01

Effects of two types of low-intensity electromagnetic fields (EMF) of industrial frequency (50 Hz) on the fine structure and proliferative activity of thymic cells in white rats were studied. It was found that a weak EMF with a prevailing electrical component (380-480 V/m, 120-140 nT1) did not affect the DNA synthesis intensity. An EMF with a stronger magnetic induction (10-15 V/m, 800-1500 nT1) diminished the glucose-6-phosphate dehydrogenase activity and proliferative processes in cultured stimulated lymphocytes. Electron microscopic investigation of the thymus after both types of exposure revealed an accumulation of lymphocytes with pyknotic nuclei and electron-dense cytoplasm, as well as hypoplasia of the vascular endothelium. At the same time, EMF with a prevailing magnetic component produced a more marked negative effect on the ultrastructure of thymic cells, which indicated a lowered secretory activity of epitheliocytes.

In vitro anti-proliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb.

Science.gov (United States)

Landa, Premysl; Skalova, Lenka; Bousova, Iva; Kutil, Zsofia; Langhansova, Lenka; Lou, Ji-Dong; Vanek, Tomas

2014-01-01

The aim of this study was to evaluate in vitro anti-proliferative (tested on MCF-7, MDA-MB-231, and MCF-10A cell lines) and anti-inflammatory (evaluated as inhibition of prostaglandin E2 synthesis catalyzed by cyclooxygenase-2) effect of various extracts from Vaccinium bracteatum leaves and fruits. The highest anti-proliferative effect possessed leaf dichloromethane extract with IC50 values ranging from 93 to 198 μg/mL. In the case of cyclooxygenase-2 inhibition, n-hexane, dichloromethane, and ethanol fruit extracts showed the best activity with IC50 values = 2.0, 5.4, and 12.7 μg/mL, respectively. These results indicate that V. bracteatum leaves and fruits could be useful source of anti-cancer and anti-inflammatory compounds.

Literary Criticism Fiction: the Wacław Borowy–Manfred Kridl polemic

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Maciej Gorczyński

2016-03-01

Full Text Available The paper The Fictions of Literary Criticism refers to a polemic between Manfred Kridl and Waclaw Borowy which was conducted in several articles published in the years 1936–1957. The polemic played a significant role in the development of modern Polish literary criticism. The matter of dispute was a new method of literary criticism announced by Kridl in his renowned Introduction to the Research of Literary Work (1936. The main topics of the discussion were the problems of the literary process, the evaluation of a literary work and the uses of scientific methods in humanities. The paper’s author pays attention especially to the rhetorical and literary means of argumentation which were used in the creation of this unusual form of non-fiction.

89 ESTABLISHING THE NEXUS BETWEEN LITERARY CRITICISM ...

African Journals Online (AJOL)

Prof Alex C Asigbo

literary critics to base their work on literary theories in order to make their ... years there has been a great surge of such thinking, much of which challenges ... of the effect produced upon the critic by the book he is .... engaging in their work.

Literary Routes: Contributions to Natural/Cultural Heritage Tourism. How landscape transforms literature and tourism

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Rosalinda Ruiz Scarfuto

2013-12-01

Full Text Available Literary routes inspired by landscapes is a topic where cultural and natural routes merge to form an added value of heritage that is greater than either one standing alone.  Landscape is traditionally defined as a consequence of transformations by humans, and its scope rarely takes into account how nature has inspired literature to advance the “intellectual development of humankind,” hence transforming heritage.  Literary routes paralleling transhumance routes embraced by the Sami, First Nations, or Spanish shepherds (full of landscapes, seascapes, and riverscapes, can actively transmit traditional technologies, biodiversity, and cosmic philosophy for the betterment of humankind; for example, the depth of literary heritage inspired by landscapes enhances our collective memory through a network of archives (libraries, collections.  The continuous dissemination of this literature traversing borders, language barriers, and time periods has stimulated literary routes to emerge as a function of moving the experience from an intangible heritage based on imaginary landscapes to a tangible sensory experience in situ following a plot, author’s life, or a myth. Literary routes respond to the demand of the growing target travellers, who are more literate and active today than in the past. They are excited followers of their favourite writers, and seek ways to be in contact with them. Now it is time to rekindle the collective memory, expand the literary dimension, and offer a sensorial in situ experience by adding a literary link. For instance, myths of the Ohlone Nation based near a California wetlands use the symbolic coyote as the intermediary to teach humans how to live in harmony with their ecosystem; or in Spain, Arcipreste de Hita’s novel El Libro de Buen Amor (1330 describes traditions and gastronomy as it criss-crosses the Guadarrama mountains, alongside the Poets’ Route that includes international Nobel prize winners in literature

Lack of a differential radiation response for proliferative and non-proliferative rat thyroid cells (FRTL-5) in vitro

International Nuclear Information System (INIS)

Brosing, J.W.; Giese, W.L.; Mulcahy, R.T.

1989-01-01

FRTL-5 rat thyroid epithelial cells maintain normal thyroid function and morphology in vitro, exhibit an absolute requirement for thyroid stimulating hormone (TSH) for proliferation and display radiation dose response characteristics indistinguishable from those of rat thyroid epithelial cells in vivo. In TSH-free medium cells remain in a non-proliferative, yet viable, state for prolonged periods of time and respond to TSH re-stimulation by a return to exponential growth. Flow cytometric analysis using two-step acridine orange (AO) staining revealed an accumulation of cells in the G1 phase of the cell cycle accompanied by a pronounced reduction in red fluorescence (indicative of RNA content) in FRTL-5 cells cultured in the absence of TSH. The response of proliferative and non-proliferative FRTL-5 cells to single dose, split dose and fractionated radiation was compared to determine whether proliferative status was an important response determinant. The response of FRTL-5 cells was not influenced by proliferative status at the time of irradiation. Additionally, dose response was not altered by variable (12 hr-8 days) non-proliferative intervals before or after irradiation. As revealed by split dose experiments, the rate and extent of sublethal damage repair was likewise similar for proliferative and non-proliferative cells. Multifraction experiments employing three fractions separated by 6 hr intervals indicate that non-proliferative FRTL-5 cells completely repair sublethal damage between fractions. These results indicate that the radiation response of FRTL-5 cells is not influenced by the proliferative status of the cells prior to or post-irradiation

Walking Through the Revolution: A Spatial Reading of Literary Echoes

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Ana Isabel Queiroz

2015-05-01

Full Text Available This paper presents an embryo of a literary guide on the Carnation Revolution to be explored for educational historical excursions other than leisure and tourism. We propose a historical trail through the centre of Lisbon, city of the Carnation Revolution, called Walk through the Revolution. The trail aims to reinforce collective memory about the major events that occurred in the early moments leading to the coup. The trail is made up by nine places of rememberance, for which literary excerpts are suggested and which are supported by a digital research procedure. A set of seven fixed and observer-independent categories are used to analyse the literary contents of 23 literary works published up to 2013. These literary works refer to events that happened between the eve of April 25 and May 1, 1974. At the same time, literary descriptions are explored using a spatial approach in order to define the literary geography of the most iconic military actions and popular demonstrations that occurred in Lisbon and the surroundings. The literary geography and the cartography of the historical events are then compared. Data analysis and visualization benefit from the use of standardised and quantitative methods, including basic statistics and geographic information systems.

Literary practice and the island

Directory of Open Access Journals (Sweden)

Aline Rocha

2016-11-01

Full Text Available http://dx.doi.org/10.5007/1984-784X.2016v16n25p146 The anthology Sobre poesia: outras vozes, published by 7Letras and edited by the literary critics Celia Pedrosa and Ida Alves, brings a sample of the poetic production scenario and of the criticism developed in the contemporaneity. Gathering nine young writers of the today Brazilian, Portuguese, Argentinian and Mexican literary scenes, the heterogeneity of the written and of the theoretical approaches has an experimental character. The selection shows, in short, a stimulus to new creative impulses.

An Exemplary High School Literary Magazine: "Cinnabar."

Science.gov (United States)

Holbrook, Hilary Taylor, Comp.

One of a series of 20 literary magazine profiles written to help faculty advisors wishing to start or improve their publication, this profile provides information on staffing and production of "Cinnabar," the magazine published by Ward Melville High School, Setauket, New York. The introduction describes the literary magazine contest (and…

The oceanic literary reading mind : An impression

NARCIS (Netherlands)

Burke, M.

2016-01-01

The mind and brain processes of the literary reading mind are most accurately defined as oceanic: the mind is an ocean. This is the essential premise that I put forward in my book Literary Reading, Cognition and Emotion: An Exploration of the Oceanic Mind (Routledge, 2011).1 The statement is of

Chemical composition, antioxidant, anti-inflammatory and anti-proliferative activities of essential oils of plants from Burkina Faso.

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Bagora Bayala

Full Text Available This research highlights the chemical composition, antioxidant, anti-inflammatory and anti-proliferative activities of essential oils from leaves of Ocimum basilicum, Ocimum americanum, Hyptis spicigera, Lippia multiflora, Ageratum conyzoides, Eucalyptus camaldulensis and Zingiber officinale. Essential oils were analyzed by gas chromatography-mass spectrometry and gas chromatography-flame ionization detector. Major constituents were α-terpineol (59.78% and β-caryophyllene (10.54% for Ocimum basilicum; 1, 8-cineol (31.22%, camphor (12.730%, α-pinene (6.87% and trans α-bergamotene (5.32% for Ocimum americanum; β-caryophyllene (21%, α-pinene (20.11%, sabinene (10.26%, β-pinene (9.22% and α-phellandrene (7.03% for Hyptis spicigera; p-cymene (25.27%, β-caryophyllene (12.70%, thymol (11.88, γ-terpinene (9.17% and thymyle acetate (7.64% for Lippia multiflora; precocene (82.10%for Ageratum conyzoides; eucalyptol (59.55%, α-pinene (9.17% and limonene (8.76% for Eucalyptus camaldulensis; arcurcumene (16.67%, camphene (12.70%, zingiberene (8.40%, β-bisabolene (7.83% and β-sesquiphellandrène (5.34% for Zingiber officinale. Antioxidant activities were examined using 1,1-diphenyl-2-picryl-hydrazyl (DPPH and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS methods. O. basilicum and L. multiflora exhibited the highest antioxidant activity in DPPH and ABTS tests, respectively. Anti-inflammatory properties were evaluated by measuring the inhibition of lipoxygenase activity and essential oil of Z. officinale was the most active. Anti-proliferative effect was assayed by the measurement of MTT on LNCaP and PC-3 prostate cancer cell lines, and SF-763 and SF-767 glioblastoma cell lines. Essential oils from A. conyzoides and L. multiflora were the most active on LNCaP and PC-3 cell lines, respectively. The SF-767 glioblastoma cell line was the most sensitive to O. basilicum and L. multiflora EOs while essential oil of A. conyzoides showed the

Anti-proliferative action of vitamin D in MCF7 is still active after siRNA-VDR knock-down

NARCIS (Netherlands)

J.L. Costa (José); P.P. Eijk (Paul); M.A. van de Wiel (Mark); D. ten Berge (Derk); F. Schmitt (Fernando); C.J. Narvaez (Carmen); J. Welsh; B. Ylstra (Bauke)

2009-01-01

textabstractBackground: The active form of Vitamin D, 1,25-dihydroxyvitamin D3(1,25D), has strong anti-proliferative effects, yet the molecular mechanisms underneath this effect remain unclear. In contrast, the molecular mechanism of 1,25D for the regulation of calcium homeostasis has principally

Endothelin-1 is associated with fibrosis in proliferative diabetic retinopathy membranes.

Science.gov (United States)

Chang, William; Lajko, Michelle; Fawzi, Amani A

2018-01-01

To characterize the relationship between endothelin-1 and fibrosis in epiretinal membranes in proliferative diabetic retinopathy and explore the role of endothelial-mesenchymal transition in these membranes. Membranes were obtained from eyes undergoing pars plana vitrectomy for complicated proliferative diabetic retinopathy or idiopathic epiretinal membrane. Through standard immunohistochemical techniques, we labeled membranes to explore the distribution of endothelin-1 and endothelin receptor B, comparing proliferative diabetic retinopathy and idiopathic epiretinal membranes. In addition, membranes were also labeled with markers for fibroblasts, endothelial, and glial cells and studied with confocal laser scanning microscopy. The intensity of endothelin-1 labeling was quantified using standard image analysis software. Fourteen membranes were included in the analysis, nine from eyes with proliferative diabetic retinopathy and five idiopathic membranes. Flatmount diabetic membranes showed co-localization of endothelin-1 with S100A4 and CD31. Immunohistochemistry and quantitative analysis of cross-sectional membranes showed significantly higher endothelin-1 labeling in proliferative diabetic retinopathy membranes compared to idiopathic membranes (pmembranes showed more elements staining positive for S100A4 compared to idiopathic membranes. Epiretinal membrane formation in proliferative diabetic retinopathy involves higher tissue levels of endothelin-1 and fibroblastic activity. Furthermore, endothelin-1, endothelial and fibroblastic staining appear to be correlated, suggestive of endothelial-to-mesenchymal transition in proliferative diabetic retinopathy.

Post-Digital Literary Studies

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Florian Cramer

2016-03-01

Full Text Available Digital humanities and digital literary studies face much the same challenges as contemporary media art: what will become of them once their media are no longer “new”, and the limitations of processing art as data have become more clearly and widely understood? This paper revisits information aesthetics and computer poetics from the 1960s and 1970s, casting them as precursors of today’s digital humanities, with many of the same issues, achievements and failures, and with their own hype cycles of boom and bust. Conversely, “post-digital” and “Post-Internet” trends in music, graphic design and visual arts may anticipate possible futures of digital humanities and literary studies after the hype has passed.

Proliferative activity of stomach cancer and assessment of individual radiosensitivity

International Nuclear Information System (INIS)

Chissov, V.I.; Sergeeva, N.S.; Dar'yalova, S.L.; Petrov, A.N.; Repina, A.G.; Belous, T.A.; Pelevina, I.I.

1991-01-01

An indirect immunofluorescent method with polyclonal antibodies to thymidine was used to assess the proliferative activity (PA-percent of cells in the S-phase of the cell cycle) of 79 stomach tumors from primary cancer patients. Stomach cancer PA was shown to vary from 0.1 to 69.7%. Stomach cancer PA did not depend either on a tumor size or a degree of the involvement of regional lymph nodes. The mean PA of well-differentiated adenocarcinoma was slightly lower (14.9±4.7%) than that of low differentiated ones. Of 79 patients a tumor process was interpreted as a resectable one in 62. They were given preoperative irradiation at a total focal dose of 36 Gy followed by operation. It was shown that tumor radioresistance could be predicted in unchanged PA indices of their increase at the beginning of a course of irradiation with the probability of 95%

Another Look at Literary Tazkares (A discussion about the typology of literary tazkares and proposing a model for classifying them

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Saeed Shafieiun

2014-12-01

Full Text Available Abstract Tazkares (anthologies, besides being one of the most basic research sources in literary sciences and being among original historical cultural sources, have generally artistic values due to their literary content and skill of their authors. Moreover, since they are sequential sources and under the influence of previous works, they also follow explicit and implicit criteria and patterns which sometimes promote them even to the level of a genre. Finding structural criteria and generic patterns of Tazkares is not an easy task because the nature of literary Tazkares is to some extent non-literary and overlaps with history and other human sciences and always wants to return to its main non-literary origins. On the other hand, since poetry and literature have been super-media in the classic world and consequently various groups of people in different periods liked them, an enormous fair of them has come into existence throughout time which has had different color and description for its customers and visitors. This matter creates many problems in the so-called literary decadence period. Due to this, generic criteria of Tazkares either remained unknown or were forgotten after the appearance of non-poets. At this point, the researcher faces contradictions repeatedly because he cannot eliminate such instances, on the one hand, and cannot gain theoretical coherence by considering them, on the other. Thus, the best possible solution is to consider separate validity for each research example and, indeed, consider prototypical and standard examples as the base of research and evaluate weaker examples as indication or extension of the main issue.  Assuming that constituents of a genre, from the most trivial and secondary to the main ones, can be studied regarding form, content and presentation, literary Tazkares can be explored as following: regarding the form, elements such as order and organization, volume, independence, literary aspect and shape

The Early Literary Reception of Ernest Hemingway in Iran

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Atefeh Ghasemnejad

2018-01-01

Full Text Available This essay investigates the dynamics that led to the literary reception of Ernest Hemingway before the Islamic Revolution in Iran. This article deploys reception studies as a branch of Comparative Literature with a focus upon conceptions of Siegbert Salomon Prawer and the practical method of George Asselineau to unearth the ideological, political, and historical milieu that embraced Hemingway’s literary fortune in Iran. This investigation, unprecedented in the study of Iranian literature, discusses how and why Hemingway was initially received in Iran. As such, the inception of literary fortune of Ernest Hemingway in Iran is examined by the contextual features, Persian literary taste, and the translator’s incentives that paved the way for this reception. This article also uncovers the reasons for the delay in the literary reception of Hemingway in Iran and discussed why some of Hemingway’s oeuvres enjoyed recognition while others were neglected by the Iranian readership.

Proliferative retinopathy predicts nephropathy

DEFF Research Database (Denmark)

Karlberg, Charlotte; Falk, Christine; Green, Anders

2012-01-01

We wanted to examine proliferative retinopathy as a marker of incident nephropathy in a 25-year follow-up study of a population-based cohort of Danish type 1 diabetic patients and to examine cross-sectional associations between nephropathy and retinopathy in long-term surviving patients of the same...... cohort. All type 1 diabetic patients from Fyn County, Denmark, were identified as of 1 July 1973. One hundred and eighty four patients were examined in 1981-1982 (baseline) and in 2007-2008 (follow-up). The level of retinopathy was graded by ophthalmoscopy at baseline and nine-field digital colour fundus...... and proliferative retinopathy, respectively. In conclusion, proliferative retinopathy is an independent marker of long-term nephropathy in type 1 diabetes. Upcoming studies should examine whether these microvascular complications are also causally linked in type 1 diabetes....

Georges Perec's literary staging

Directory of Open Access Journals (Sweden)

Ewelina Woźniak-Czech

2017-12-01

Full Text Available The purpose of this sketch to present Georges Perec’s work in the context of drama. As Perec wrote just one play for the theater, it’s hard to call him a dramatist. However, it is easy to see that all the literary tricks he uses in his works are a part of a well-thought-out game. The author of Life a User’s Manual employs and interweaves various literary conventions, prompts dialogue between his own works and draws the reader into the very center of his tricks, nuances and simulations. Perec’s writing could be deemed a pure act of dramatization, where the author himself, to some extent, takes on the role of director, making his audience not so much the recipients of his texts but the actors performing them.

Gustav Shpet's Literary and Theatre Theory

OpenAIRE

Tihanov, Galin

2007-01-01

In his paper, "Gustav Shpet's Literary and Theatre Theory," Galin Tihanov introduces Shpet's theoretical work on literature and theatre, until recently little studied. Neither has been sufficient attention paid to Shpet's overall presence on the Russian cultural scene in the 1910s-1930s. As a result, our knowledge and appreciation of the scope of his writings and the variety of Russian literary and theatre life in the first third of the twentieth century have remained less rich and well-infor...

Picture Books Featuring Literary Characters with Special Needs

Directory of Open Access Journals (Sweden)

Batič Janja

2013-11-01

Full Text Available This paper introduces a selection of picture books that feature a person with special needs as the main literary character. The selection of the books to be showcased was based on three crucial aspects: the form of the (picture book, as we wanted to underline the visual importance of a literary character with special needs; the age limit of the readers the books are intended for (preschool and early primary school; and undisputable quality of the literary and artistic components of the picture books. The picture books we have selected based on the above criteria are Veveriček posebne sorte by Svetlana Makarovič and Marjan Manček, Mrožek dobi očala by Peter Svetina and Mojca Osojnik, and Zakaj je babica jezna by Lela B. Njatin and Alenka Sottler. Picture books about literary characters with special needs can help highly sensitive children accepting people that are different, while children with special needs can build a better self-image based on such books. Quality literary books which foster a positive attitude towards a character with special needs promote tolerance and can thus play an important role in the early childhood, with regard to awareness of an inclusive society.

Non-Proliferative Diabetic Retinopathy Vision Simulator

Science.gov (United States)

... Oncology Oculoplastics/Orbit Refractive Management/Intervention Retina/Vitreous Uveitis Focus On Pediatric Ophthalmology ... Retinopathy Diagnosis Diabetic Retinopathy Treatment Proliferative Diabetic Retinopathy Vision Simulator Non-Proliferative Diabetic ...

Revisiting Style, a Key Concept in Literary Studies

NARCIS (Netherlands)

Herrmann, J. Berenike; van Dalen-Oskam, K.H.; Schöch, Christof

2015-01-01

Language and literary studies have studied style for centuries, and even since the advent of ›stylistics‹ as a discipline at the beginning of the twentieth century, definitions of ›style‹ have varied heavily across time, space and fields. Today, with increasingly large collections of literary texts

The magic of Rudaki's thought and literary language

Directory of Open Access Journals (Sweden)

M.S Basiri

2009-06-01

Full Text Available This article, at first, discuses the fact that language is the most important means of human being to reach the fact and beauty. Language is a means of logical thinking rather than a way of communication. However, literary language in Rudaki's poetry has the best capacity to identify and reveal mental concepts through using aesthetics. The main question of this article is how Rudaki connected language to thought and what is his artistic creation? For this reason the researcher, after presenting and considering evidences, proves that Rudaki has used all characteristics of language and principals of creative language to connect literary language and thought together. The most prominent elements of Rudaki's thought and literary language are: using the most proper words in collocation, distinguishing the relationship of cause and effect and existence through literary language, asserting artistic fact, using imagination and principles of association of meanings, and entering poetical experience in language dominion (domain.

A New Perspective of Literary Criticism

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Deng Jun

2009-05-01

Full Text Available Paratext is a relatively new term in literary criticism, which is mainly elaborated by modern French scholar Gérard Genette. Article presents a qualitative method with its purpose to present a survey to this new literary term and probe into what may lie behind this new critic perspective. Analysis was done by exploring the new literatures in terms of paratext. It can be concluded that paratext has a great influence to the deeper understanding from different perspectives of a literature work. 

Korean Ginseng Berry Fermented by Mycotoxin Non-producing Aspergillus niger and Aspergillus oryzae: Ginsenoside Analyses and Anti-proliferative Activities.

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Li, Zhipeng; Ahn, Hyung Jin; Kim, Nam Yeon; Lee, Yu Na; Ji, Geun Eog

2016-01-01

To transform ginsenosides, Korean ginseng berry (KGB) was fermented by mycotoxin non-producing Aspergillus niger and Aspergillus oryzae. Changes of ginsenoside profile and anti-proliferative activities were observed. Results showed that A. niger tended to efficiently transform protopanaxadiol (PPD) type ginsenosides such as Rb1, Rb2, Rd to compound K while A. oryzae tended to efficiently transform protopanaxatriol (PPT) type ginsenoside Re to Rh1 via Rg1. Butanol extracts of fermented KGB showed high cytotoxicity on human adenocarcinoma HT-29 cell line and hepatocellular carcinoma HepG2 cell line while that of unfermented KGB showed little. The minimum effective concentration of niger-fermented KGB was less than 2.5 µg/mL while that of oryzae-fermented KGB was about 5 µg/mL. As A. niger is more inclined to transform PPD type ginsenosides, niger-fermented KGB showed stronger anti-proliferative activity than oryzae-fermented KGB.

Synthesis, characterization and anti-proliferative activity of heterocyclic hypervalent organoantimony compounds.

Science.gov (United States)

Chen, Yi; Yu, Kun; Tan, Nian-Yuan; Qiu, Ren-Hua; Liu, Wei; Luo, Ning-Lin; Tong, Le; Au, Chak-Tong; Luo, Zi-Qiang; Yin, Shuang-Feng

2014-05-22

Three heterocyclic hypervalent organoantimony chlorides RN(CH2C6H4)2SbCl (2a R = t-Bu, 2b R = Cy, 2c R = Ph) and their chalcogenide derivatives [RN(CH2C6H4)2Sb]2O (3a R = t-Bu, 3b R = Cy, 3c R = Ph) were synthesized and characterized by techniques such as (1)H NMR, (13)C NMR, X-ray diffraction, and elemental analysis. It is found that the anti-proliferative activity detected over these compounds can be attributed to the coordination bond between the antimony and nitrogen atoms of these compounds. Moreover, a preliminary study on mechanistic action suggests that the inhibition effect is ascribable to cell cycle arrest and cell apoptosis. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Database in Theory and Practice: The Bibliography of Irish Literary Criticism

Science.gov (United States)

Howell, Sonia

2013-01-01

Focusing on "The Bibliography of Irish Literary Criticism" (BILC, 2010), a bibliographical database of Irish literary criticism developed by humanities and information and communications technology (ICT) researchers in NUI Maynooth, this chapter investigates the opportunities and implications afforded the field of Irish literary studies…

An Exemplary High School Literary Magazine: "Et Cetera."

Science.gov (United States)

Holbrook, Hilary Taylor, Comp.

One of a series of 20 literary magazine profiles written to help faculty advisors wishing to start or improve their publication, this profile provides information on staffing and production of "Et Cetera," the magazine published by Clarkstown High School, New City, New York. The introduction describes the literary magazine contest (and…

Roles of tissue plasminogen activator and its inhibitor in proliferative diabetic retinopathy

Institute of Scientific and Technical Information of China (English)

Shu-Ling; Wu; Dong-Mei; Zhan; Shu-Hong; Xi; Xiang-Lian; He

2014-01-01

AIM:To investigate the role of tissue plasminogen activator(t-PA) and plasminogen activator inhibitor(PAI)in proliferative diabetic retinopathy(PDR) and to discuss the correlations among t-PA, PAI and vascular endothelial growth factor(VEGF) expressions.METHODS:A total of 36 vitreous samples were collected from 36 patients with PDR(PDR group), and 17 vitreous samples from 17 patients with idiopathic macular hole were used as control. The concentrations of t-PA, PAI and VEGF in samples were determined by ELISA method. The correlations among t-PA, PAI and VEGF expressions were discussed.RESULTS:The concentrations of t-PA, PAI and VEGF in the PDR group were significantly higher than those in the control group(P <0.001). The t-PA and PAI expressions were highly correlated with the VEGF expression(P <0.001).CONCLUSION:In addition to VEGF, a variety of bioactive substances, such as t-PA and PAI, are involved in the pathogenesis involved in the angiogenesis of PDR.VEGF can activate t-PA expression, resulting in collagen tissue degradation and angiogenesis. VEGF may also activate the mechanism for endogenous anti-neovascularization.

Proliferative activity of elastin-like-peptides depends on charge and phase transition.

Science.gov (United States)

Yuan, Yuan; Koria, Piyush

2016-03-01

Elastin-like-peptides (ELPs) are stimulus-responsive protein-based polymers and are attractive biomaterials due to their biocompatibility and unique properties. This study shows that in addition to their physical properties, ELPs have biological activities that are conducive to tissue regeneration. Specifically, we found that ELPs induce fibroblast proliferation via cell surface heparan sulfate proteoglycans (HSPG). Furthermore, our data suggests that ELP based materials with differential proliferative potential can be designed by controlling the interaction of ELPs with HSPGs by incorporating either hydrophobic or positively charged residues within the ELP sequence. Fibroblast proliferation is important for granulation tissue formation which is important in chronic wounds as well as in healing of other tissues. The customizable biological activity of ELPs coupled with their unique physical properties will enable us to design novel, sustainable and cost effective therapies for different tissue regeneration applications. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 697-706, 2016. © 2015 Wiley Periodicals, Inc.

Deconstruction Literary Theory and a Creative Reading of "The Great Gatsby."

Science.gov (United States)

Dennis, Deborah; Trotman, Charlene C.

Through the mid-1980s, resistance to contemporary literary theory (especially Jacques Derrida's philosophy of deconstruction) took the form of a bitter debate that enlivened literary journals and Modern Language Association meetings. The debate continues even today, with traditional literary critics rejecting deconstruction as nihilistic and…

Reading Minds: Using Literary Resources in Family Therapy.

Science.gov (United States)

Burns, Liz

A qualitative enquiry explored, with a range of family therapists and systemic practitioners, the influence they perceive to have been made on their personal and professional lives by the literary texts they have read. Noting that "literary" is broadly interpreted to include poetry, prose, drama/film, song lyrics, etc., the study's aims…

Literary translation into indigenous languages in Nigeria and ...

African Journals Online (AJOL)

This study makes out a case for the thorny problem of literary translation into Nigeria's indigenous languages and its role in national development. In this paper, we outline the way forward given the fact that literary translation into Nigerian languages had gone through a sticky patch. Federal, State and Local governments in ...

Estrogen signaling in the proliferative endometrium: implications in endometriosis

Directory of Open Access Journals (Sweden)

Rita de Cássia Pereira da Costa e Silva

2016-02-01

Full Text Available SUMMARY Even though the physiological role of estrogen in the female reproductive cycle and endometrial proliferative phase is well established, the signaling pathways by which estrogen exerts its action in the endometrial tissue are still little known. In this regard, advancements in cell culture techniques and maintenance of endometrial cells in cultures enabled the discovery of new signaling mechanisms activated by estrogen in the normal endometrium and in endometriosis. This review aims to present the recent findings in the genomic and non-genomic estrogen signaling pathways in the proliferative human endometrium specifically associated with the pathogenesis and development of endometriosis.

Immunoregulatory activities of human immunodeficiency virus (HIV) proteins: Effect of HIV recombinant and synthetic peptides on immunoglobulin synthesis and proliferative responses by normal lymphocytes

International Nuclear Information System (INIS)

Nair, M.P.N.; Pottathil, R.; Heimer, E.P.; Schwartz, S.A.

1988-01-01

Recombinant and synthetic peptides corresponding to envelope proteins of the human immunodeficiency virus (HIV) were examined for their effects on the activities of lymphocytes from normal donors in vitro. Although lymphocytes cultured with env-gag peptides produced significant amounts of IgG, addition of env-gag peptides to a pokeweed mitogen-induced B-cell activation system resulted in suppression of immunoglobulin synthesis by normal lymphocytes. Recombinant antigens, env-gag and env-80 dihydrofolate reductase (DHFR), produced a substantial proliferative response by peripheral blood mononuclear cells (PBMC) as determined by [ 3 H]thymidine incorporation. PBMC precultured with HIV synthetic peptide env 578-608 also manifested significant proliferative responses as compared to control cultures. CD3 + lymphocytes precultured with recombinant HIV antigens, env-gag and env-80 DHFR, and synthetic HIV peptide, env 487-511, showed moderate but significant proliferative responses. Both recombinant antigens and synthetic peptides also produced a dose-dependent stimulatory effect on proliferation by CD3 - lymphocytes. These studies demonstrate that recombinant and synthetic peptides of the HIV genome express immunoregulatory T- and B-cell epitopes. Identification of unique HIV epitopes with immunogenic and immunoregulatory activities is necessary for the development of an effective vaccine against HIV infection

Levels of Literary Meaning

DEFF Research Database (Denmark)

Klausen, Søren Harnow

2017-01-01

I argue that intentionalist theories of meaning and interpretation, like those of Hirsch and Juhl, have been insufficiently attentive to the different levels of authorial intention that are operative in literary works. By countenancing intentions on different levels – ranging from simple semantic...

Cervantes and Literary Preceptive

Directory of Open Access Journals (Sweden)

Miguel Ángel Garrido Gallardo

2014-12-01

Full Text Available The historiography of literary culture often links the Quixote and, by extension, the work of Cervantes with the Preceptive, a theme that perseveringly appears in the curricular studies from the late seventeenth century to the early twentieth century. Not being literary Preceptive more than a normative version of the Poetics and Rhetoric, this paper examines the possible relationship of Cervantes’ work with the normative aspect of both disciplines, such as they flourished in the sixteenth century and early seventeenth century. The symptomatic example of Juan de la Cueva’s El Ejemplar poético (1606 is explored and the itinerary of three possible relationships is followed: the acceptance or rejection of the current preceptive by the author, the presumed adoption of the preceptive as a set of generative rules of its own creation and the use of Cervantes’ production as an example and lesson for the future preceptive.

Structural and functional development of rat and mouse gastric mucous cells in relation to their proliferative activity

International Nuclear Information System (INIS)

Wattel, W.

1978-01-01

An investigation has been carried out to find a relation between the differentiation and the mitotic activity of gastric mucous cells of the rat and the mouse. It is shown that the bulk mucous production is carried out by the older, non-proliferative, surface mucous cells that line the foveolae and the gastric surface. One experiment describes the renewal of mouse gastric mucous cells following fast neutron irradiation. (C.F.)

Proliferation Index and Karyometric Features of Pancreatic Intraductal Proliferative Lesions

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Romana Tomaszewska

1999-01-01

Full Text Available The increasing frequency and poor prognosis in pancreatic cancer prompt us to search for morphological lesions being a substrate for its development. Studies of autopsy and surgically resected material as well as recent molecular studies have proved that one of the possible pathways of pancreatic neoplasia is the intraepithelial proliferation – dysplasia – cancer sequence. In the present paper we studied the proliferative activity (Ki‐67 index in pancreatic intraepithelial proliferative lesions and its correlation with geometric features of cell nuclei as signs of increasing dysplasia. The studies were carried out in a group of 35 patients operated on for pancreatic cancer, chronic pancreatitis and other conditions not associated with the pancreas. We used immunohistochemical methods and basic morphometric parameters. The results of our studies indicate that the cell proliferative activity depends both on the type of epithelial proliferation and underlying pancreatic disease. The values of Ki‐67 index are significantly different in low‐grade proliferation (flat and papillary hyperplasia and high‐grade proliferation (atypical papillary hyperplasia and carcinoma in situ. A set of karyometric features correlates with Ki‐67 index but there is no single feature which would have a diagnostic value.

Noninvasive Evaluation of Cellular Proliferative Activity in Brain Neurogenic Regions in Rats under Depression and Treatment by Enhanced [18F]FLT-PET Imaging.

Science.gov (United States)

Tamura, Yasuhisa; Takahashi, Kayo; Takata, Kumi; Eguchi, Asami; Yamato, Masanori; Kume, Satoshi; Nakano, Masayuki; Watanabe, Yasuyoshi; Kataoka, Yosky

2016-08-03

Neural stem cells in two neurogenic regions, the subventricular zone and the subgranular zone (SGZ) of the hippocampal dentate gyrus, can divide and produce new neurons throughout life. Hippocampal neurogenesis is related to emotions, including depression/anxiety, and the therapeutic effects of antidepressants, as well as learning and memory. The establishment of in vivo imaging for proliferative activity of neural stem cells in the SGZ might be used to diagnose depression and to monitor the therapeutic efficacy of antidepressants. Positron emission tomography (PET) imaging with 3'-deoxy-3'-[(18)F]fluoro-l-thymidine ([(18)F]FLT) has been studied to allow visualization of proliferative activity in two neurogenic regions of adult mammals; however, the PET imaging has not been widely used because of lower accumulation of [(18)F]FLT, which does not allow quantitative assessment of the decline in cellular proliferative activity in the SGZ under the condition of depression. We report the establishment of an enhanced PET imaging method with [(18)F]FLT combined with probenecid, an inhibitor of drug transporters at the blood-brain barrier, which can allow the quantitative visualization of neurogenic activity in rats. Enhanced PET imaging allowed us to evaluate reduced cell proliferation in the SGZ of rats with corticosterone-induced depression, and further the recovery of proliferative activity in rats under treatment with antidepressants. This enhanced [(18)F]FLT-PET imaging technique with probenecid can be used to assess the dynamic alteration of neurogenic activity in the adult mammalian brain and may also provide a means for objective diagnosis of depression and monitoring of the therapeutic effect of antidepressant treatment. Adult hippocampal neurogenesis may play a role in major depression and antidepressant therapy. Establishment of in vivo imaging for hippocampal neurogenic activity may be useful to diagnose depression and monitor the therapeutic efficacy of

Orna Me: Laurence Sterne’s Open Letter to Literary History

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Celia B. Barnes

2016-12-01

Full Text Available This essay considers the curious way Laurence Sterne communicates with and reflects on his literary predecessors, most often Alexander Pope, by writing love letters to women. Focusing primarily on his correspondence with Elizabeth Draper, Barnes contends that, even as Sterne looks back to Pope to guarantee himself a place in literary history, he looks forward to women like Draper to ensure his name will survive.  Thus, erotic correspondence becomes an important way of ensuring Sterne’s literary estate, or as he terms it, his “futurity.” “Orna Me”—a phrase that means, roughly, “ornament me” or “set me off,” and that Sterne got from Pope and Swift, who got it from Cicero—allows Sterne to plug in to a literary tradition that privileges collaboration: append something of yours to something of mine. It is this idea of letter-writing as correspondence, a collaborative process between friends or lovers, that unites Sterne to his female correspondent and to literary tradition all at once.

3,3'-Diindolylmethane, a cruciferous vegetable derived synthetic anti-proliferative compound in thyroid disease

International Nuclear Information System (INIS)

Tadi, Kiranmayi; Chang Yushan; Ashok, Badithe T.; Chen, Yuangen; Moscatello, Augustine; Schaefer, Steven D.; Schantz, Stimsom P.; Policastro, Anthony J.; Geliebter, Jan; Tiwari, Raj K.

2005-01-01

Considerable epidemiological evidence exists to link thyroid disease with differing patterns of dietary consumption, in particular, cruciferous vegetables. We have been studying the anti-thyroid cancer (TCa) activity of indole-3-carbinol (I3C) found in cruciferous vegetables and its acid catalyzed dimer, 3,3'-diindolylmethane (DIM). There are no studies as yet to elucidate the effect of these compounds on the altered proliferative patterns in goiter or thyroid neoplasia. In this study, we tested the anti-proliferative effects of I3C and DIM on four different thyroid cancer cell lines representative of papillary (B-CPAP and 8505-C) and follicular carcinoma of the thyroid (CGTH-W-1 and ML-1), and primary human goiter cells. Cell survival and IC 50 values for I3C and DIM were calculated by the XTT assay and cell cycle distribution analysis was done by flow cytometry. DIM was found to be a better anti-proliferative agent than I3C in both papillary and follicular TCa resulting in a greater cytotoxic effect at a concentration over three fold lower than predicted by the molar ratio of DIM and I3C. The anti-proliferative activity of DIM in follicular TCa was mediated by a G1 arrest followed by induction of apoptosis. DIM also inhibited the growth of primary goiter cells by 70% compared to untreated controls. Contrary to traditional belief that cruciferous vegetables are 'goitrogenic,' DIM has anti-proliferative effects in glandular thyroid proliferative disease. Our preclinical studies provide a strong rationale for the clinical exploration of DIM as an adjuvant to surgery in thyroid proliferative disease

In vitro anti-proliferative activity of clove extract on human gastric carcinoma

Directory of Open Access Journals (Sweden)

A. Karimi

2017-10-01

Full Text Available Background and objectives: Cancer cell resistance to common chemotherapy agents is on rise. Plants are considered valuable sources of herbal drugs for cancer therapy. The present study was conducted to investigate the in vitro antioxidant, anti-proliferative, and apoptosis-inducing properties of clove (Syzygium aromaticum L. extract in human gastric carcinoma (AGS. Methods: Crude ethanol extract of S. aromaticum dried buds was prepared and  in vitro anti-proliferative effects of the extract on AGS and normal Human dermal fibroblasts (HDF cell lines were studied by MTT assay. To examine apoptosis induction, AGS cells were incubated with IC50 concentrations of the extract, stained with propidium iodide (PI and annexin V-fluorescein isothiocyanate (FITC, and analyzed by flow cytometry. Antioxidant activity and total phenolics and flavonoids contents were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH assay, Folin-Ciocalteu method, and aluminum chloride colorimetric method, respectively. Results: The IC50 of DPPH and total phenolics and flavonoids contents of the extract were 10.05±1.93 μg/mL, 225.6±40 mg GAE/g, and 29.30±2.35 mgRUT/g, respectively. The IC50 of the extract against HDFs was 649 µg/mL, higher than AGS cells, which was 118.7 g/mL at 48 h after treatment. Flow cytometric analysis showed that the extract induced cell apoptosis. Conclusions: Crude ethanol S. aromaticum extract had high total phenolics content, and suppressed the proliferation of human gastric cancer cells, likely due to apoptosis induction. Further studies should be conducted to determine the mechanisms of its anticancer effects.

Peeling the Onion: Student Teacher's Conceptions of Literary Understanding.

Science.gov (United States)

Carlsson, Maj Asplund; Fulop, Marta; Marton, Ference

2001-01-01

Studied the theories student teachers held about literary understanding through interviews with 25 Hungarian and 8 Swedish student teachers. Categories of theories captured a substantial portion of the variation in how literary understanding can be seen. Three central aspects of human understanding, variation, discernment, and simultaneity, could…

Downregulation of TXNIP leads to high proliferative activity and estrogen-dependent cell growth in breast cancer.

Science.gov (United States)

Park, Jun Won; Lee, Su Hyung; Woo, Gye-Hyung; Kwon, Hyo-Jung; Kim, Dae-Yong

2018-04-06

TXNIP is a potent tumor suppressor with reduced expression in various types of human cancer. The prognostic and predictive power of TXNIP has been recognized in human breast cancer. The aim of this study is to investigate the clinical relevance and functional roles of TXNIP downregulation in breast cancer. We examined TXNIP expression at the protein level in tissue microarray (TMA)-based human breast cancers and its correlation with clinical parameters and molecular markers on immunohistochemistry (IHC). Compared with normal tissues, TXNIP expression was significantly decreased in human breast cancer tissues and animal mammary tumors, along with tumor progression. TXNIP was restored immediately after histone deacetylase inhibitor treatment in breast cancer cells, implying transcriptional regulation of TXNIP by histone modification. Decreased TXNIP protein levels were more common in tumors showing high proliferative activity, such as high Ki-67 labeling indexes and low p27 expression. TXNIP knockdown led to increased in vitro and in vivo breast cancer cell growth accompanied by p27 reduction and GLUT1 induction. Interestingly, estrogen receptor (ER)-positive breast cancer samples showed higher TXNIP expression compared to ER-negative samples. TXNIP expression decreased when ER signaling was activated by estradiol, while its expression increased under ER blockage by anti-estrogen fulvestrant. In addition, TXNIP knockdown in breast cancer cells caused significant reduction in the cell-growth inhibitory effect of anti-estrogen fulvestrant. In conclusion, our data demonstrated that TXNIP functions to suppress high proliferative activity and estrogen-dependent cell growth in breast cancer. Copyright © 2018 Elsevier Inc. All rights reserved.

Stylistic Performance through Affective Marking: A Case of Multilingual Literary Discourse

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Urjani Chakravarty

2016-12-01

Full Text Available This paper provides an overall analysis of how multi-lingual writer like Amitav Ghosh write about emotion in his literary text, and emphasize on how multilingual authors display emotion/affect through use of literary multilingualism (affective markers combined with writer style. Through use of multiple strategies, they reduces the limitations of interpretation of their texts. Furthermore, this paper highlighted the centrally sociolinguistic and cognitive dimensions of the relationships between multilingualism and emotion and how this is influenced by assumptions of Relevance Theory i.e. optimal relevance in a literary text. One should expect to find relationships between sociolinguistic diversity and affective expression for most authors in locally specific ways, whether multilingual or not. Such scholarship can then illuminate how the authors by using literary multilingualism through writer style and affective markers can shape emotions across various contexts in a literary text. Future research into multilingualism and emotion should continue to distinguish between how multilingual authors use linguistic forms to show feeling, and how they express about feeling in their created texts. Keywords: Language, Culture, Literary Multilingualism, Style, Affect and Relevance Theory

Reacting in Literary Studies: Crossing the Threshold from Quality to Meaning

Science.gov (United States)

Heinert, Jennifer; Chick, Nancy L.

2017-01-01

In this essay, the authors extend their ongoing conversations within the overarching project on "critique as signature pedagogy in the arts and humanities" by considering how the position of literary studies within this broader context may explain some of the difficulties students have with a cornerstone activity of the undergraduate…

An Exemplary High School Literary Magazine: "The Thinking Reed."

Science.gov (United States)

Holbrook, Hilary Taylor, Comp.

One of a series of 20 literary magazine profiles written to help faculty advisors wishing to start or improve their publication, this profile provides information on staffing and production of "The Thinking Reed," the magazine published by Bethlehem Central High School, Delmar, New York. The introduction describes the literary magazine…

Post-digital Books and Disruptive Literary Machines

DEFF Research Database (Denmark)

Pold, Søren Bro; Andersen, Christian Ulrik

The e-book has been launched several times during the last decades and the book’s demise has often been predicted. Furthermore networked and electronic literature has already established a long history. However, currently we witness several interesting artistic and literary experiments exploring...... to sketch out how contemporary literary technologies is integral to develop and reflect critically on post- or semio-capitalism, and furthermore we will discuss how literature functions in a post-industrial software culture such as the one presented by Apple, Amazon and Google....

Cytosol cathepsin-D content and proliferative activity of human breast cancer. The Comitato Italiano per il Controllo di Qualita del Laboratorio in Oncologia.

Science.gov (United States)

Paradiso, A; Mangia, A; Correale, M; Abbate, I; Ferri, G; Piffanelli, A; Catozzi, L; Amadori, D; Riccobon, A; De Lena, M

1992-01-01

Mitogenic properties have been demonstrated in vitro for the lysosomal acidic protease cathepsin-D (cath-D). We investigated possible relationships between cath-D cytosol cell content and tumor proliferative activity in a series of 129 operable breast cancer patients. For total cytosol cath-D evaluation, a solid phase two-site immunoradiometric assay was utilized on tumor cell cytosol obtained for hormone receptor assay (DCC method). The percentage of S-phase cells was analyzed by 3H-thymidine autoradiographic assay. Median 3H-thymidine Labeling Index (3H-Tdr-LI) of the series was 2.7%; median cath-D content resulted 57 pmol/mg of protein cytosol and was significantly higher in node-positive with respect to the node-negative subgroup (p < 0.03). When classified in low, intermediate or high tumor cath-D content and slow or fast proliferative activity (cut-off: median values of the series), no significant agreement was found between the two variables. Statistical analysis, however, showed that a significant inverse correlation existed in node positive tumors between cath-D and 3H-Tdr-LI values which was even more evident in N-positive high estrogen receptor-positive (ER+) cases (coefficient of correlation = 0.6828; p = 0.0001). Cytosol cath-D content cannot be generally proposed as a direct marker of proliferative activity for operable breast cancer.

Nooruse valuuta. „Noorkirjanik“ ja „rühmitus“ nullindatel / The Currency of Youth. The "Young Author" and the "Literary Group" in the 2000s

Directory of Open Access Journals (Sweden)

Priit Kruus

2013-06-01

Full Text Available The article is focused on literary groups and the emergence of young authors in the 2000s. So far literary researchers have mainly studied the influential literary groups of the first third of the 20th century (Noor-Eesti, Siuru, Tarapita etc.. But literary groups have had a remarkable impact on contemporary Estonian literature as well. Many present-day well-known writers entered the literary scene through groups which were active in the 1990s (e.g. TNT and Erakkond. In the 2000s forming a literary group lost its appeal as young authors found more individual ways to introduce themselves to the public. At the beginning of the 2000s a couple of attempts were made to form new literary groups, but those groups were short-lived and unproductive (e.g. TNT! and !peatus.Young authors were very active in publishing both on paper and online. The emergence of new publishing channels is one of the reasons why young authors did not have the ambition or need to form groups. For example, in the 2000s literary debuts appeared in the web-based literary club POOGEN and the literary magazine Värske Rõhk (established in 2005. So the 2000s actually saw a new type of convergence: web-based literary clubs and forums. Unfortunately, many of the new channels of the 2000s are already out of reach: the web pages of KLOAAK, noortekas.delfi.ee, People&Poetry, Bahama Press and ThePression have been removed from the internet.Debuts were welcomed by mainstream media eager to spot the next big thing, new rebels and rule breakers. Being “a young author” became a functioning brand, and youth became a form of currency for beginning writers.

A canonical-literary reading of Lamentations 5 | Kang | HTS ...

African Journals Online (AJOL)

This article presents a canonical and literary reading of Lamentations 5 in the context of the book of Lamentations as a whole. Following the approach by Vanhoozer (1998, 2002) based on speech-act theory, the meaning of Scripture is sought at canonical level, supervening the basic literary level. In Lamentations, as ...

Narrativity and enaction: the social nature of literary narrative understanding.

Science.gov (United States)

Popova, Yanna B

2014-01-01

This paper proposes an understanding of literary narrative as a form of social cognition and situates the study of such narratives in relation to the new comprehensive approach to human cognition, enaction. The particular form of enactive cognition that narrative understanding is proposed to depend on is that of participatory sense-making, as developed in the work of Di Paolo and De Jaegher. Currently there is no consensus as to what makes a good literary narrative, how it is understood, and why it plays such an irreplaceable role in human experience. The proposal thus identifies a gap in the existing research on narrative by describing narrative as a form of intersubjective process of sense-making between two agents, a teller and a reader. It argues that making sense of narrative literature is an interactional process of co-constructing a story-world with a narrator. Such an understanding of narrative makes a decisive break with both text-centered approaches that have dominated both structuralist and early cognitivist study of narrative, as well as pragmatic communicative ones that view narrative as a form of linguistic implicature. The interactive experience that narrative affords and necessitates at the same time, I argue, serves to highlight the active yet cooperative and communal nature of human sociality, expressed in the many forms than human beings interact in, including literary ones.

Narrativity and Enaction: The Social Nature of Literary Narrative Understanding

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Yanna B. Popova

2014-08-01

Full Text Available This paper proposes an understanding of literary narrative as a form of social cognition and situates the study of such narratives in relation to the new comprehensive approach to human cognition, enaction. The particular form of enactive cognition that narrative understanding is proposed to depend on is that of participatory sense-making, as developed in the work of Di Paolo and De Jaegher. Currently there is no consensus as to what makes a good literary narrative, how it is understood, and why it plays such an irreplaceable role in human experience. The proposal thus identifies a gap in the existing research on narrative by describing narrative as a form of intersubjective process of sense-making between two agents, a teller and a reader. It argues that making sense of narrative literature is an interactional process of co-constructing a story-world with a narrator. Such an understanding of narrative makes a decisive break with both text-centered approaches that have dominated both structuralist and early cognitivist study of narrative, as well as pragmatic communicative ones that view narrative as a form of linguistic implicature. The interactive experience that narrative affords and necessitates at the same time, I argue, serves to highlight the active yet cooperative and communal nature of human sociality, expressed in the many forms than human beings interact in, including literary ones.

EUGEN SIMION – (LITERARY CRITIC – A FORM OF CHARACTER

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Dr. Lucian CHIŞU

2013-05-01

Full Text Available The article presents the life and activity of one of the greatest contemporary Romanian literary critics. President of the Romanian Academy, member of the French Academy of Art s, Eugen Simion approached the work of classical and contemporary Romanian writers as well as that of international writers such as E. Ionescu, E. Cioran, M. Eliade, P. Popescu.

Proliferative and inflammatory factors in the vitreous of patients with proliferative diabetic retinopathy

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V V Chernykh

2015-01-01

Full Text Available Purpose: The purpose was to measure the concentrations of various cytokines and growth factors (including vascular endothelial growth factor [VEGF] and pigment epithelium-derived factor [PEDF] in the vitreous of patients with proliferative diabetic retinopathy (PDR and to investigate interaction between inflammatory and proliferative factors in the genesis of PDR. Materials and Methods : Vitreous samples from 32 eyes with PDR and 25 eyes without diabetes mellitus and signs of DR (control were collected. Vitreous concentrations of VEGF, PEDF, monocyte chemotactic protein-1 (MCP-1, interleukin-4 (IL-4, IL-6, IL-8, IL-10, IL-17A, and secretory immunoglobulin A (sIgA were simultaneously measured using enzyme-linked immunoassay. Results : Vitreous levels of VEGF, PEDF, IL-17A, IL-6, IL-8, IL-4, and sIgA were significantly (Π < 0.05 higher in eyes with PDR compared to control. The concentration of VEGF was more than 17-times higher than in control, and the concentration of PEDF was not changed oppositely and was also higher (1.45-times compared to control, that may indicate disturbances of compensatory mechanisms in angiogenesis regulation in PDR. Significant (Π < 0.05 positive correlations were observed between vitreous concentrations of VEGF and IL-17ΐ (r = 0.45, VEGF and IL-8 (r = 0.48, VEGF and IL-4 (r = 0.51, PEDF and IL-17ΐ (r = 0.48, PEDF and IL-8 (r = 0.59, MCP-1 and PEDF (r = 0.72, MCP-1 and IL-8 (r0 = 0.45, IL-4 and IL-17ΐ (r = 0.65, IL-4 and IL-8 (r = 0.71, IL-8 and IL-17ΐ (r = 0.59. Conclusions: Significantly raised levels of inflammatory and proliferative factors and numerous positive correlations between them may demonstrate a significant role of activation of vascular proliferation and local inflammation in the pathogenesis of PDR.

Ethnic boundaries in national literary histories: Classification of ethnic minority fiction authors in American, Dutch and German anthologies and literary history books, 1978-2006

NARCIS (Netherlands)

P.P.L. Berkers (Pauwke)

2009-01-01

textabstractThis article compares the classification of ethnic minority fiction writers in American, Dutch and German literary anthologies and literary history books for the period of 1978-2006. Using content analyses, ethnic boundaries are much stronger in Dutch and German textbooks than in their

Benign Proliferative Breast Lesions and Risk of Cancer

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Serap Erel

2010-06-01

Full Text Available Benign breast lesions (BBL includes a wide variety of histologic entities, which have been broadly classified into non-proliferative lesions, proliferative lesions without atypia, and hyperplasia with atypia. With the increased use of mammography, more benign lesions are being detected, and in order to estimate the risk of breast cancer for specific histologic categories is of great importance to guide clinical management. Women with proliferative lesions without atypia are at slightly increased risk of subsequent breast cancer, whereas women with proliferative lesions with atypia have a higher risk. The risk is 1.5- 2-fold in women with proliferative lesions without atypia, 4-5-fold in women with proliferative lesions with atypia, and 8-10 fold in women with ductal carcinoma in situ. Age at diagnosis of BBL, menopausal status, family history of breast cancer in a first-degree relative, and time since BBL diagnosis on risk of breast cancer are important for risk evaluation. [Archives Medical Review Journal 2010; 19(3.000: 155-167

Adolescents, curriculum, and literary competence

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Guadalupe López Bonilla

2006-11-01

Full Text Available In this paper we look at access to literary texts, and analyze literacy practices in a specific context and domain: high school literature classes. We start out from a sociocultural perspective for our study of literacy events and practices. In particular, we have begun our research supported by the work of Mary Hamilton and the New Literacy Studies to identify events and their components, in order to infer the practices that give meaning to the events observed. The study was conducted in a state high school (COBACH, and in a federal high school offering two different programs: the General Diploma (GD, similar to that of the COBACH, and the International Baccalaureate Diploma (IB. The results allow us to surmise what type of reader and level of literary competency is offered by each scholastic culture.

Literary Library for Physicians (II

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Fernando A. NAVARRO

2015-10-01

Full Text Available The adequate practice of medicine is a difficult job if some intimate and deep feelings of patients, such pain, loneliness, depression and helplessness facing an incurable disease or the fear of dying, are not fully understood. A good way to gain a satisfactory understanding of such feelings might be the reading of the great literary works of all times. In this “Medical library for physicians” an essential list of seventy literary works from the Modern to the Contemporary periods has been collected. Their plot is about the disease, the madness, the hospital, the professionalism and the historical and social images of the physicians. In the second part of the article, a brief review of the last thirty?five books is carried out. It considers from Sinuhe egyptiläinen (1945 by Mika Waltari to Nemesis (1943 by Philip Roth.

“The Writer Is Essentially Indiscrete.” On the Literary Gossip of a Dutch Literary Celebrity

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Bax Sander

2017-11-01

Full Text Available In contemporary media culture, literary writers arouse the fascination of media fans by awakening in them the desire for the authentic by publishing autobiographical novels or other forms of life narrative. In doing so, they run the risk of becoming part of media’s large gossip mechanism that plays such a central role nowadays. The public conversation about the books of writers such as the Dutch author Connie Palmen - whose Logboek van een onbarmhartig jaar will be the main case study of this article - becomes focused on the elements of truth and authenticity and ignores the literary or fictional construction of the work. This article discusses the question whether this leaves any room for contemporary star authors to distinguish themselves from media gossipers.

Girl-Child Education and Nigeria's Development Agenda: a Literary ...

African Journals Online (AJOL)

We have therefore taken a literary trajectory of select literary female characters with a view to positioning them against the background of their access or otherwise to education (formal and informal), and how this plays out in the shaping of their lives vis-à-vis the Nigerian girl-child's prospect of enhancing herself with a view ...

Immunohistochemical Estimates of Angiogenesis, Proliferative Activity, p53 Expression, and Multiple Drug Resistance Have No Prognostic Impact in Osteosarcoma: A Comparative Clinicopathological Investigation

DEFF Research Database (Denmark)

Sørensen, Flemming Brandt; Jensen, Kenneth; Vaeth, Michael

2008-01-01

Purpose. To investigate angiogenesis, multiple drug resistance (MDR) and proliferative activity as prognostic variables in patients suffering from osteosarcoma. Methods. Histologic biopsies from 117 patients treated in the period from 1972 through 1999 were immunohistologically investigated...

In vitro anti-proliferative effect of interferon alpha in solid tumors: A potential predicative test

International Nuclear Information System (INIS)

Fuchsberger, N.; Kubes, M.; Kontsek, P.; Borecky, L.; Hornak, M.; Silvanova; Godal, A.; Svec, J.

1993-01-01

An in vitro test for the anti-proliferative effect of human leukocyte interferon (IFN-alpha) was performed in primary cultures of tumor cells obtained from 32 patients with either malignant melanoma (13), renal carcinoma (4) or bladder carcinoma (15). Our results demonstrated activity of IFN in all three groups of solid tumors. However, appreciable differences in sensitivity to anti-proliferative effect of IFN between individual tumors of the same type were found. The potential of this anti-proliferative test for prediction of treatment response in IFN-therapy is discussed. (author)

Empathy at the confluence of neuroscience and empirical literary studies

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Burke, M.; Mangen, Anne; Kuzmicova, Anezka; Schilhab, Theresa

2016-01-01

The objective of this article is to review extant empirical studies of empathy in narrative reading in light of (a) contemporary literary theory, and (b) neuroscientific studies of empathy, and to discuss how a closer interplay between neuroscience and literary studies may enhance our understanding

Literary Research and Canadian Literature: Strategies and Sources. Literary Research--Strategies and Sources #10

Science.gov (United States)

Reznowski, Gabriella

2011-01-01

Canada's rich literary heritage, dominated by a multicultural and multilingual presence, reflects the country's unique history and experience. In addition, an emerging body of new writers is redefining both the geographic and metaphorical boundaries of Canadian literature. Coupled with the propagation of digital technologies, Canada's burgeoning…

Parody as a Phenomenon of Literary Criticism

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Natalіia Naumenko

2017-11-01

Full Text Available The article elucidates the properties of a parody as not only an art work, but also as a literary-critical study. There is shown that the parody, according to the creative invention of its author, has the purpose to expose and then to deride the certain disadvantages of on original poetic text; however, in closer reading, it seems to maintain a critical paradigm. First of all, this paradigm reveals all of the noticed flaws as the remedy to make “the creative prophylactics” for a future poet; second, it helps a reader to comprehend as well the positive features of a parodied text (particularly, in reading an original, and also to imagine the image of an author (of either the original or the parody opened to further interpretations. The subjects of studies in this article are Ukrainian literary parodies published throughout the 20th – the beginning of the 21st centuries (authors – Ostap Vyshnia, V. Yaremenko, Yu. Ivakin, A. Bortnyak, I. Havryliuk; there are also analyzed several poetic works that are not parodies a priori, but tend to deride some realia of the authors’ everyday life. There was shown that the efficiency of literary criticism could be defined by not only what the critic said, but also how one did it. Therefore, elucidation of a parody seems to be impossible without studying its generic, stylistic, imagery and compositional characteristics of a potential parody object (original verse work, including the specifications of development of a poet’s individual style within parodying any kind of literary works.

Effect of Enterococcus faecium EF 55 on morphometry and proliferative activity of intestinal mucosa in broilers infected with Salmonella Enteritidis

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Ševčíková Zuzana

2016-09-01

Full Text Available Introduction: The present study aimed to investigate the effect of Enterococcus faecium EF55 on chickens, as well as its influence on proliferative activity of epithelial intestinal cells after infection with Salmonella enterica serovar Enteritidis phage type 4 (SE PT4. Moreover, the length and area of duodenal and jejunal villi of the birds were examined.

Bernhard Linde. Noor-Eesti vooriülem. Bernhard Linde. Leader of the Young Estonian Pack

OpenAIRE

Jaanus Kulli

2012-01-01

Bernhard Linde (1886–1954) was a recognized and prolific Estonian theatre critic of the first quarter of the 20th century, who mediated and propagated western as well as eastern European theatrical innovations. In addition, he was active as a literary and art critic, publisher, and proponent of libraries, to a modest extent he was a prose writer and poet. Unquestionably, however, Bernhard Linde’s most prominent role was as one of the founding members of the literary movement Young Estonia. He...

Representativeness in corpora of literary texts: introducing the C18P project

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Gemeinböck, Iris

2016-07-01

Full Text Available Currently there are very few specialised corpora of literary texts that are tailored to the needs of literary critics who are interested in corpus stylistic analyses of prose fiction. Many existing corpora including literary texts were compiled for linguistic research interests and are often unsuitable for corpus stylistic purposes. The paper addresses three of the main problems: the absence of labelling of the texts for literary genre, the use of extracts, and the prevalence of linguistic periodisation schemes. C18P is a corpus of prose fiction designed specifically to address these issues. It traces the early development of the novel from 1700 up until the Victorian era. It can, for instance, be used for an analysis of the characteristic linguistic features of individual literary genres and forms. The following paper introduces the design of the corpus as well as some of its potential uses.

Reconsidering the Nature of the Unconscious: A Question on Psychoanalysis in Literary Studies

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L. Suharjanto, SJ

2017-01-01

Full Text Available Psychoanalysis has been used invariably in literary studies, as it helps literary interpretation to touch the often-puzzling-dimension of motives and feelings in literary works. The domination of psychoanalysis in the twentieth century, however, has been questioned with the new awareness that the unconscious mind is not innate but constructed. Such a disposition challenges not only the practice of using psychoanalysis in literary studies but also the validity of psychoanalysis itself.   DOI: https://doi.org/10.24071/llt.2012.150104

uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERS

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Mariana Rodrigues Faleiro

2013-06-01

Full Text Available Prostatic lesions such as prostatic intraepithelial neoplasia (PIN and proliferative inflammatory atrophy (PIA are studied in human and canine species due to their malignance potential. The plasminogen activator (PA system has been suggested to play a central role in cell adhesion, angiogenesis, inflammation, and tumor invasion. The urokinase-type plasminogen activator receptor (uPAR is a component of the PA, with a range of expression in tumor and stromal cells. In this study, uPAR expression in both canine normal prostates and with proliferative disorders (benign prostatic hyperplasia-BPH, proliferative inflammatory atrophy-PIA, prostatic intraepithelial neoplasia-PIN, and carcinoma-PC was evaluated by immunohistochemistry in a tissue microarray (TMA slide to establish the role of this enzyme in extracellular matrix (ECM remodeling and in the processes of tissue invasion. A total of 298 cores and 355 diagnoses were obtained, with 36 (10.1% normal prostates, 46 (13.0% with BPH, 128 (36.1% with PIA, 74 (20.8% with PIN and 71 (20.0% with PC. There is variation in the expression of uPAR in canine prostate according to the lesion, with lower expression in normal tissue and with BPH, and higher expression in tissue with PIA, PIN and PC. The high expression of uPAR in inflammatory and neoplastic microenvironment indicates increased proteolytic activity in canine prostates with PIA, PIN, and PC.

Application of Freudian Concepts to the Explication of Literary Texts ...

African Journals Online (AJOL)

This article established and proved the age old relationship between. Psychology and Literature together with the application of Freudian concepts to the explication of literary texts. The interest of literary critics from Sigmund Freud to Jacques Lacan has been noticeable and remarkable in the field of psychoanalytic criticism.

Calcium/calmodulin-dependent protein kinase II activity regulates the proliferative potential of growth plate chondrocytes.

Science.gov (United States)

Li, Yuwei; Ahrens, Molly J; Wu, Amy; Liu, Jennifer; Dudley, Andrew T

2011-01-01

For tissues that develop throughout embryogenesis and into postnatal life, the generation of differentiated cells to promote tissue growth is at odds with the requirement to maintain the stem cell/progenitor cell population to preserve future growth potential. In the growth plate cartilage, this balance is achieved in part by establishing a proliferative phase that amplifies the number of progenitor cells prior to terminal differentiation into hypertrophic chondrocytes. Here, we show that endogenous calcium/calmodulin-dependent protein kinase II (CamkII, also known as Camk2) activity is upregulated prior to hypertrophy and that loss of CamkII function substantially blocks the transition from proliferation to hypertrophy. Wnt signaling and Pthrp-induced phosphatase activity negatively regulate CamkII activity. Release of this repression results in activation of multiple effector pathways, including Runx2- and β-catenin-dependent pathways. We present an integrated model for the regulation of proliferation potential by CamkII activity that has important implications for studies of growth control and adult progenitor/stem cell populations.

Reading a suspenseful literary text activates brain areas related to social cognition and predictive inference.

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Moritz Lehne

Full Text Available Stories can elicit powerful emotions. A key emotional response to narrative plots (e.g., novels, movies, etc. is suspense. Suspense appears to build on basic aspects of human cognition such as processes of expectation, anticipation, and prediction. However, the neural processes underlying emotional experiences of suspense have not been previously investigated. We acquired functional magnetic resonance imaging (fMRI data while participants read a suspenseful literary text (E.T.A. Hoffmann's "The Sandman" subdivided into short text passages. Individual ratings of experienced suspense obtained after each text passage were found to be related to activation in the medial frontal cortex, bilateral frontal regions (along the inferior frontal sulcus, lateral premotor cortex, as well as posterior temporal and temporo-parietal areas. The results indicate that the emotional experience of suspense depends on brain areas associated with social cognition and predictive inference.

Two novel prenylated kaempferol derivatives from fresh bud's fur of Platanus acerifolia and their anti-proliferative activities.

Science.gov (United States)

Zuo, Bo; Liao, Zhi-Xin; Xu, Chen; Liu, Chao

2016-01-06

Two novel prenylated kaempferol derivatives (1, 2), together with seven known metabolites were isolated from ethanol extract of fresh Platanus acerifolia bud's fur by multistep chromatographic processing. Structure of compounds 1 and 2 was confirmed by 1D, 2D NMR spectra and HR-ESI-MS. In addition, compound 1 was further analysed by X-ray crystallography. Anti-proliferative activities in vitro against human breast carcinoma (MCF-7) and human hepatocellular carcinoma (Hep-G2) cell lines for compound 1, 2 and 8 were evaluated. Compound 1 exhibited cytotoxic activity towards MCF-7 and Hep-G2 cell lines with the IC 50 values 38.2 and 39.5 μM, respectively. Moreover, compound 2 showed weak cytotoxic activities against the two cell lines.

The Use of "Literary Fiction" to Promote Mentalizing Ability.

Science.gov (United States)

Pino, Maria Chiara; Mazza, Monica

2016-01-01

Empathy is a multidimensional process that incorporates both mentalizing and emotional sharing dimensions. Empathic competencies are important for creating interpersonal relationships with other people and developing adequate social behaviour. The lack of these social components also leads to isolation and exclusion in healthy populations. However, few studies have investigated how to improve these social skills. In a recent study, Kidd and Castano (2013) found that reading literary fiction increases mentalizing ability and may change how people think about other people's emotions and mental states. The aim of our study was to evaluate the effects of reading literary fiction, compared to nonfiction and science fiction, on empathic abilities. Compared to previous studies, we used a larger variety of empathy measures and utilized a pre and post-test design. In all, 214 healthy participants were randomly assigned to read a book representative of one of three literary genres (literary fiction, nonfiction, science fiction). Participants were assessed before and after the reading phase using mentalizing and emotional sharing tests, according to Zaki and Ochsner' s (2012) model. Comparisons of sociodemographic, mentalizing, and emotional sharing variables across conditions were conducted using ANOVA. Our results showed that after the reading phase, the literary fiction group showed improvement in mentalizing abilities, but there was no discernible effect on emotional sharing abilities. Our study showed that the reading processes can promote mentalizing abilities. These results may set important goals for future low-cost rehabilitation protocols for several disorders in which the mentalizing deficit is considered central to the disease, such as Autism Spectrum Disorders and Schizophrenia.

Proliferative lifespan is conserved after nuclear transfer.

Science.gov (United States)

Clark, A John; Ferrier, Patricia; Aslam, Samena; Burl, Sarah; Denning, Chris; Wylie, Diana; Ross, Arlene; de Sousa, Paul; Wilmut, Ian; Cui, Wei

2003-06-01

Cultured primary cells exhibit a finite proliferative lifespan, termed the Hayflick limit. Cloning by nuclear transfer can reverse this cellular ageing process and can be accomplished with cultured cells nearing senescence. Here we describe nuclear transfer experiments in which donor cell lines at different ages and with different proliferative capacities were used to clone foetuses and animals from which new primary cell lines were generated. The rederived lines had the same proliferative capacity and rate of telomere shortening as the donor cell lines, suggesting that these are innate, genetically determined, properties that are conserved by nuclear transfer.

Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts.

Science.gov (United States)

Sitte, N; Merker, K; von Zglinicki, T; Grune, T

2000-03-01

One of the highlights of age-related changes of cellular metabolism is the accumulation of oxidized proteins. The aging process on a cellular level can be treated either as the ongoing proliferation until a certain number of cell divisions is reached (the Hayflick limit) or as the aging of nondividing cells, that is, the age-related changes in cells without proliferation. The present investigation was undertaken to reveal the changes in protein turnover, proteasome activity, and protein oxidation status during proliferative senescence. We were able to demonstrate that the activity of the cytosolic proteasomal system declines dramatically during the proliferative senescence of human MRC-5 fibroblasts. Regardless of the loss in activity, it could be demonstrated that there are no changes in the transcription and translation of proteasomal subunits. This decline in proteasome activity was accompanied by an increased concentration of oxidized proteins. Cells at higher proliferation stages were no longer able to respond with increased degradation of endogenous [(35)S]-Met-radiolabeled proteins after hydrogen peroxide- or quinone-induced oxidative stress. It could be demonstrated that oxidized proteins in senescent human MRC-5 fibroblasts are not as quickly removed as they are in young cells. Therefore, our study demonstrates that the accumulation of oxidized proteins and decline in protein turnover and activity of the proteasomal system are not only a process of postmitotic aging but also occur during proliferative senescence and result in an increased half-life of oxidized proteins.

Painting local colour: a sociolinguistic disposition of the literary artist ...

African Journals Online (AJOL)

Literary artists have advanced human ways of life through their writings. Hence, literature as a work of art merely lends credence to these persuasions by literary artists. It is possible to describe 'Culture' as the art, literature, music and other intellectual expressions of a particular society or time. Therefore, literature being an ...

Retinal vessel caliber as a potential marker of treatment outcome in patients with proliferative diabetic retinopathy

DEFF Research Database (Denmark)

Vergmann, Anna Stage; Torp, Thomas Lee; Lundberg, Kristian

Title of abstract: Retinal vessel caliber as a potential marker of treatment outcome in patients with proliferative diabetic retinopathy Design of study: Three months prospective, interventional clinical study. Purpose: The retinal vascular tree can be measured non-invasively and summarized...... into the central retinal artery and vein equivalent (CRAE and CRVE). The purpose of this study was to evaluate retinal calibers as biomarkers for disease activity 3 months after panretinal photocoagulation (PRP) in patients with proliferative diabetic retinopathy (PDR). Methods: Fifty one eyes from 40 newly...... with proliferative diabetic retinopathy....

Using Literary Texts to Teach Grammar in Foreign Language Classroom

Science.gov (United States)

Atmaca, Hasan; Günday, Rifat

2016-01-01

Today, it is discussed that the use of literary texts in foreign language classroom as a course material isn't obligatory; but necessary due to the close relationship between language and literature. Although literary texts are accepted as authentic documents and do not have any purpose for language teaching, they are indispensable sources to be…

Crime Writing in Southern Africa: A Literary Example of the ...

African Journals Online (AJOL)

Crime writing, long time considered to be of minor quality, generally seeks to reach a large audience. As a literary genre it entered Western history around the 1850s. Literary critics view the origins of this genre in the economic, political and cultural developments of the 19th Century based on various sociological data, ...

Literary Studies: A Preparation for Tertiary Education (and Life Beyond)

Science.gov (United States)

Zabka, Thomas

2016-01-01

My argument is that a literary education should build on a primary level of responsivity towards literature, involving empathy and immersion in the world of the text. To engage with literary works from the past involves a play between familiarity and strangeness, and this play should be located as part of a reader's response to texts, rather than…

INFORMATION AND COMMUNICATION TECHNOLOGY IN ORGANIZATION OF EXTRACURRICULAR WORK WITH GIFTED STUDENTS IN THE SYSTEM OF THE LITERARY EDUCATION

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Ольга Петрович

2014-10-01

Full Text Available The article deals with the issue of features of the use of information and communication technology in organizing extra-curricular activities with the literary gifted students. Main attention is drawn on the effective forms and methods of information and communication technology for the successful conduction of extracurricular activities with gifted high school students in literary education system, in particular such as: web quests, QR-codes, QR-quests, Google Groups, multimedia presentations, blogging, virtual tours, use of interactive whiteboards, educational forums, databases educational resources, virtual libraries, creating the electronic portfolio, media library of educational material, comics, doodles, clouds of words etc.

Reading Parallel Texts in the Target Language: A Way to Improve Literary Translation Quality

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Nazanin Shadman

2013-10-01

Full Text Available The present study was an attempt to investigate the effect of reading Persian literary texts on the quality of literary translations. To this end, 52 students majoring in English translation were randomly assigned to two groups. A Comprehensive English Language Test (CELT was administered to check the homogeneity of the participants. The treatment for the experimental group consisted of reading 60 Persian short stories and poems. In the meantime, the control group went through their ordinary course curriculum. Both groups were asked to translate extracts of two short stories. The translations were then rated. Through statistical analysis, it was revealed that reading Persian literary works, indeed, improves the quality of literary translations. Therefore, to promote a more fruitful instruction on literary translation, it is suggested that translation teachers attempt to consider reading Persian literary works as part of the curriculum and ask students to read Persian texts to the extent possible, so that more qualified translations would be rendered in the area of literature.

Comprehension of atypical literary text and scholastic achievement

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Božin Aurel A.

2009-01-01

Full Text Available With the aim of gaining insight into literary text comprehension and the linkage between that comprehension and scholastic achievement during the first years of schooling, a research was conducted on the sample of 152 third and fourth grade pupils from one urban and one rural school. After having read silently a selected atypical excerpt from one literary text, interviewed pupils filled out the questionnaire constructed for the purposes of this research starting from the 11 categories of text comprehension singled out based on the theory of comprehension and interpretation of literary text and the current curriculum. In the first part of the research we applied the Children's orientation scale by Malka Margalit, and school marks were used as a measurement of scholastic achievement. Research results point out that, among other things, inferring on the basis of what has been read poses the greatest difficulty for third and fourth graders, that is, that almost three quarters of them are not capable of determining the meaning of some representative sentences from that text. In the positive sense, it was established that almost three quarters of them perceive beautiful poetic expressions and about 80% of them can at least to a certain extent recognize character descriptions, emotional situations and moods, that is, discover significant facts. Answers to the questions regarding the majority of categories of text comprehension are significantly correlated with scholastic achievement. As expected, the highest correlations between the measures on text comprehension categories are with the marks in native (Serbian language. Partial correlations between the measures on certain categories of text comprehension and measurements of scholastic achievement (excluding the influence of feeling of coherence are not significantly different from bivariate. Based on the obtained data, authors conclude that the utilized system of categories can be a useful tool for

WRITTEN FAITH: LITERARY ELEMENTS OF ITALIAN IMMIGRATION IN SOUTH BRAZIL

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Maria Catarina Chitolina Zanini

2013-12-01

Full Text Available This article aims to present and analyze literary productions drawn up by descendants of Italian settlers in Rio Grande do Sul (Brazil and highlight how religiosity is a recurring theme present in this texts. This is a migration process that has more than a century and the writing activity proved to be a very usable tool in conservation (and construction of collectives or individuals memories for the contemporary generations.

A City on the Brink of Apocalypse: Mexico City's Urban Ecology in Works by Vicente Leñero and Homero Aridjis

Science.gov (United States)

Larochelle, Jeremy G.

2013-01-01

At a conference on environmental change in Latin America, Homero Aridjis, writer, environmental activist, and founder of the Grupo de los Cien, quoted Yeats when answering my question about the connection between his prolific literary work and untiring activism: "In dreams begin responsibility." He later explained that through writing…

Evaluation of the anti-proliferative and cytotoxic potentials of ...

African Journals Online (AJOL)

The partitioned aqueous and chloroform fractions obtained from the methanol extract of the leaf of Cnidoscolus aconitifolius were examined for anti-proliferative (1-30 mg/mL) and cytotoxic activities (20-400 μg/mL) using the seed radicle inhibition and tadpole mortality assays over a period of 24 and 96 h respectively.

Esculetin exerts anti-proliferative effects against non-small-cell lung carcinoma by suppressing specificity protein 1 in vitro.

Science.gov (United States)

Lee, Ra H; Jeon, Young-Joo; Cho, Jin H; Jang, Jeong-Yun; Kong, Il-Keun; Kim, Seok-Ho; Kim, MinSeok S; Chung, Hak-Jae; Oh, Keon B; Park, Seon-Min; Shin, Jae-Cheon; Seo, Jae-Min; Ko, Sungho; Shim, Jung-Hyun; Chae, Jung-Il

2017-01-01

Esculetin, a coumarin derivative, is a phenolic compound isolated from Artemisia capillaris, Citrus limonia, and Euphorbia lathyris. Although it has been reported to have anti-inflammatory, anti-oxidant, and anti-proliferative activities in several human cancers, its anti-proliferative activity against non-small-cell lung carcinoma (NSCLC) and the molecular mechanisms involved have not been adequately elucidated. In this study, we used two NSCLC cell lines (NCI-H358 and NCI-H1299) to investigate the anti-proliferative activity and apoptotic effect of esculetin. Our data showed that esculetin-treated cells exhibited reduced proliferation and apoptotic cell morphologies. Intriguingly, the transcription factor specificity protein 1 (Sp1) was significantly suppressed by esculetin in a dose- and time-dependent manner. Furthermore, the levels of p27 and p21, two key regulators of the cell cycle, were up-regulated by the esculetin-mediated down-regulation of Sp1; the level of a third cell-cycle regulator, survivin, was decreased, resulting in caspase-dependent apoptosis. Therefore, we conclude that esculetin could be a potent anti-proliferative agent in patients with NSCLC.

Individual Differences in Sensitivity to Style During Literary Reading: Insights from Eye-Tracking

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Emiel van den Hoven

2016-12-01

Full Text Available Style is an important aspect of literature, and stylistic deviations are sometimes labeled foregrounded, since their manner of expression deviates from the stylistic default. Russian Formalists have claimed that foregrounding increases processing demands and therefore causes slower reading – an effect called retardation. We tested this claim experimentally by having participants read short literary stories while measuring their eye movements. Our results confirm that readers indeed read slower and make more regressions towards foregrounded passages as compared to passages that are not foregrounded. A closer look, however, reveals significant individual differences in sensitivity to foregrounding. Some readers in fact do not slow down at all when reading foregrounded passages. The slowing down effect for literariness was related to a slowing down effect for high perplexity (unexpected words: those readers who slowed down more during literary passages also slowed down more during high perplexity words, even though no correlation between literariness and perplexity existed in the stories. We conclude that individual differences play a major role in processing of literary texts and argue for accounts of literary reading that focus on the interplay between reader and text.

Reading literary fiction improves theory of mind.

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Kidd, David Comer; Castano, Emanuele

2013-10-18

Understanding others' mental states is a crucial skill that enables the complex social relationships that characterize human societies. Yet little research has investigated what fosters this skill, which is known as Theory of Mind (ToM), in adults. We present five experiments showing that reading literary fiction led to better performance on tests of affective ToM (experiments 1 to 5) and cognitive ToM (experiments 4 and 5) compared with reading nonfiction (experiments 1), popular fiction (experiments 2 to 5), or nothing at all (experiments 2 and 5). Specifically, these results show that reading literary fiction temporarily enhances ToM. More broadly, they suggest that ToM may be influenced by engagement with works of art.

The critic as transvestite: the parody nature of literary criticism

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David Pruneda Sentíes

2016-09-01

Full Text Available This paper explores a path in the analysis of literary criticism as an object of study. In order to convey this, this essay attempts to define literary criticism as a genre that parodies the literary text it aspires to examine. Mikhail Bakhtin’s analysis of the novelistic discourse is useful to establish a connection between parody and criticism. Although Bakhtin discusses the novel, I ascertain that his arguments may be applied to the description of criticism as a parodic-travestying genre. Secondly, this paper discusses Linda Hutcheon’s work, which states that parody is a repetition of the original text. According to Hutcheon, this repetition implies a critical distance with the parodied text, which marks difference rather than similarity.

[Eugenics, an element of the literary plots of dystopia].

Science.gov (United States)

Baum, Ewa; Musielak, Michał

2007-01-01

The work presents the ideas and assumptions of eugenics, a social philosophy established in 1883 by Francis Galton, which affected the social policies of numerous European countries in the first half of the 20th century. The work shows the effect of eugenics on the literary standards of European prose in the previous century. Two outstanding dystopian novels of the 20th century, The Brave New World by Aldous Huxley and 1984 by George Orwell, situate eugenics as a permanent element of the literary plot of dystopia. Apart from the typical features of this type of novel, for example: personal narration with a trace of irony, a totalitarian state and Newspeak, eugenics is an important element of the literary plot with is aim to exclude and marginalise certain social groups. Eugenics is also one of the main social ideas criticised by both the writers.

Comparative Study of Green Sub- and Supercritical Processes to Obtain Carnosic Acid and Carnosol-Enriched Rosemary Extracts with in Vitro Anti-Proliferative Activity on Colon Cancer Cells

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Andrea del Pilar Sánchez-Camargo

2016-12-01

Full Text Available In the present work, four green processes have been compared to evaluate their potential to obtain rosemary extracts with in vitro anti-proliferative activity against two colon cancer cell lines (HT-29 and HCT116. The processes, carried out under optimal conditions, were: (1 pressurized liquid extraction (PLE, using an hydroalcoholic mixture as solvent at lab-scale; (2 Single-step supercritical fluid extraction (SFE at pilot scale; (3 Intensified two-step sequential SFE at pilot scale; (4 Integrated PLE plus supercritical antisolvent fractionation (SAF at pilot scale. Although higher extraction yields were achieved by using PLE (38.46% dry weight, this extract provided the lowest anti-proliferative activity with no observed cytotoxic effects at the assayed concentrations. On the other hand, extracts obtained using the PLE + SAF process provided the most active rosemary extracts against both colon cancer cell lines, with LC50 ranging from 11.2 to 12.4 µg/mL and from 21.8 to 31.9 µg/mL for HCT116 and HT-29, respectively. In general, active rosemary extracts were characterized by containing carnosic acid (CA and carnosol (CS at concentrations above 263.7 and 33.9 mg/g extract, respectively. Some distinct compounds have been identified in the SAF extracts (rosmaridiphenol and safficinolide, suggesting their possible role as additional contributors to the observed strong anti-proliferative activity of CA and CS in SAF extracts.

Identification of literary movements using complex networks to represent texts

International Nuclear Information System (INIS)

Amancio, Diego Raphael; Oliveira, Osvaldo N Jr; Fontoura Costa, Luciano da

2012-01-01

The use of statistical methods to analyze large databases of text has been useful in unveiling patterns of human behavior and establishing historical links between cultures and languages. In this study, we identified literary movements by treating books published from 1590 to 1922 as complex networks, whose metrics were analyzed with multivariate techniques to generate six clusters of books. The latter correspond to time periods coinciding with relevant literary movements over the last five centuries. The most important factor contributing to the distinctions between different literary styles was the average shortest path length, in particular the asymmetry of its distribution. Furthermore, over time there has emerged a trend toward larger average shortest path lengths, which is correlated with increased syntactic complexity, and a more uniform use of the words reflected in a smaller power-law coefficient for the distribution of word frequency. Changes in literary style were also found to be driven by opposition to earlier writing styles, as revealed by the analysis performed with geometrical concepts. The approaches adopted here are generic and may be extended to analyze a number of features of languages and cultures. (paper)

Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74

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Djudjaj, Sonja; Lue, Hongqi; Rong, Song; Papasotiriou, Marios; Klinkhammer, Barbara M.; Zok, Stephanie; Klaener, Ole; Braun, Gerald S.; Lindenmeyer, Maja T.; Cohen, Clemens D.; Bucala, Richard; Tittel, Andre P.; Kurts, Christian; Moeller, Marcus J.; Floege, Juergen; Ostendorf, Tammo

2016-01-01

Pathologic proliferation of mesangial and parietal epithelial cells (PECs) is a hallmark of various glomerulonephritides. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that mediates inflammation by engagement of a receptor complex involving the components CD74, CD44, CXCR2, and CXCR4. The proliferative effects of MIF may involve CD74 together with the coreceptor and PEC activation marker CD44. Herein, we analyzed the effects of local glomerular MIF/CD74/CD44 signaling in proliferative glomerulonephritides. MIF, CD74, and CD44 were upregulated in the glomeruli of patients and mice with proliferative glomerulonephritides. During disease, CD74 and CD44 were expressed de novo in PECs and colocalized in both PECs and mesangial cells. Stress stimuli induced MIF secretion from glomerular cells in vitro and in vivo, in particular from podocytes, and MIF stimulation induced proliferation of PECs and mesangial cells via CD74. In murine crescentic GN, Mif-deficient mice were almost completely protected from glomerular injury, the development of cellular crescents, and the activation and proliferation of PECs and mesangial cells, whereas wild-type mice were not. Bone marrow reconstitution studies showed that deficiency of both nonmyeloid and bone marrow–derived Mif reduced glomerular cell proliferation and injury. In contrast to wild-type mice, Cd74-deficient mice also were protected from glomerular injury and ensuing activation and proliferation of PECs and mesangial cells. Our data suggest a novel molecular mechanism and glomerular cell crosstalk by which local upregulation of MIF and its receptor complex CD74/CD44 mediate glomerular injury and pathologic proliferation in GN. PMID:26453615

In vitro anti-proliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb

OpenAIRE

Landa, P. (Přemysl); Skálová, L.; Boušová, I.; Kutil, Z. (Zsófia); Langhansová, L. (Lenka); Lou, J.D.; Vaněk, T. (Tomáš)

2014-01-01

The aim of this study was to evaluate in vitro anti-proliferative (tested on MCF-7, MDA-MB-231, and MCF-10A cell lines) and anti-inflammatory (evaluated as inhibition of prostaglandin E2 synthesis catalyzed by cyclooxygenase-2) effect of various extracts from Vaccinium bracteatum leaves and fruits. The highest anti-proliferative effect possessed leaf dichloromethane extract with IC50 values ranging from 93 to 198 mug/mL. In the case of cyclooxygenase-2 inhibition, n-hexane, dichloromethane, a...

Proliferative Activity of Mammary Carcinoma Cells by AgNOR Count in C3H mice Receiving Ethanol Extract of Sponge Haliclona sp

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Sijabat, Lanceria; Susilaningsih, Neni; Trianto, Agus; Murwani, Retno

2018-02-01

Quantification of argyrophilic nucleolar organizer region (AgNORs) was considered as one of markers of proliferative activity of cancer cells. Sponge Haliclona sp extract contains anticancer bioactive compounds and our previous study showed that the extract was able to improve histological grade of induced mammary adenocarcinoma in mice. The following research was conducted to study the extract administration on the proliferative activity of the carcinoma cells represented by AgNOR count in mice. This experimental study applied post test only control group design. Twenty C3H mice were divided into four groups namely C (control), H1, H2 and H3. Each group was given 0, 0.15, 1.5, and 15 mg Haliclona sp extract respectively. After three weeks of extract administration, mice were inoculated with breast cancer cells from donor mice. The extract administration were continued for another three weeks. AgNOR count was performed on tumor sections and expressed as mean of AgNOR (mAgNOR) and percentage of AgNOR (pAgNOR). Means of mAgNOR in C, H1, H2 and H3 were 4.070, 3.195, 3.450, and 3.190 respectively. Means of pAgNOR in C, H1, H2 and H3 were 34,40, 25,40, 38,40 and 19,80 respectively. The lowest means of mAgNOR and pAgNOR which is an indication of lower proliferative activity of the cancer cells was found in H3. However no significant difference can be found among treatment groups (p>0.05). Using AgNOR count, the ethanol extract of Haliclona sp could not show significant reduction in proliferation of mammary carcinoma cells of C3H mice. This finding support the view that AgNOR alone could not be used to determine pathology of cancer cells.

A Literary Study on Moschus

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Kyu Jae Lee

2005-12-01

Full Text Available Objective : Literary investigation of existing data was conducted to verify effects of Moschus and its herbal acupuncture, and determine quality management through component analysis. Results : Following results were obtained through literary investigation. 1. Deer musk (Moschus is dried navel gland secretions of the adult male musk deer. 2. Moschus is known to be effective for treating various febrile diseases, to revive senses, heart and abdominal pain, complications from cerebral hemorrhage, angina, and others. 3. Single dosage of Moschus is between and should not exceed 1g. Normally taken as powder or pill and may be used externally. 4. Moschus also has protective effects for the liver cells, and experiments revealed possible efficacies for hyperlipidemia, brain damage, hypertension, and etc. 5. For herbal acupuncture usage, Fel Ursi, Bezoar Bovis, and Moschus are used as a mixture (BUM, and it's known to be effective for protecting the liver and treating arthritis. 6. For component analysis of Moschus, aromatic matter 'muscone' should be used as a standard matter.

The Use of “Literary Fiction” to Promote Mentalizing Ability

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Mazza, Monica

2016-01-01

Empathy is a multidimensional process that incorporates both mentalizing and emotional sharing dimensions. Empathic competencies are important for creating interpersonal relationships with other people and developing adequate social behaviour. The lack of these social components also leads to isolation and exclusion in healthy populations. However, few studies have investigated how to improve these social skills. In a recent study, Kidd and Castano (2013) found that reading literary fiction increases mentalizing ability and may change how people think about other people’s emotions and mental states. The aim of our study was to evaluate the effects of reading literary fiction, compared to nonfiction and science fiction, on empathic abilities. Compared to previous studies, we used a larger variety of empathy measures and utilized a pre and post-test design. In all, 214 healthy participants were randomly assigned to read a book representative of one of three literary genres (literary fiction, nonfiction, science fiction). Participants were assessed before and after the reading phase using mentalizing and emotional sharing tests, according to Zaki and Ochsner’ s (2012) model. Comparisons of sociodemographic, mentalizing, and emotional sharing variables across conditions were conducted using ANOVA. Our results showed that after the reading phase, the literary fiction group showed improvement in mentalizing abilities, but there was no discernible effect on emotional sharing abilities. Our study showed that the reading processes can promote mentalizing abilities. These results may set important goals for future low-cost rehabilitation protocols for several disorders in which the mentalizing deficit is considered central to the disease, such as Autism Spectrum Disorders and Schizophrenia. PMID:27490164

U.S. National Certification in Literary Braille: History and Current Administration

Science.gov (United States)

Bell, Edward

2010-01-01

This article reports on a certification examination for teachers of students with visual impairments--the National Literary Braille Competency Test (NLBCT). It discusses the history, development, pilot testing, and validation of NLBCT and the creation of the National Certification in Literary Braille. Data on the current administration of the test…

Stylistic Performance through Affective Marking: A Case of Multilingual Literary Discourse

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Chakravarty, Urjani

2016-01-01

This paper provides an overall analysis of how multi-lingual writer like Amitav Ghosh write about emotion in his literary text, and emphasize on how multilingual authors display emotion/affect through use of literary multilingualism (affective markers) combined with writer style. Through use of multiple strategies, they reduces the limitations of…

Twitter Fiction: A New Creative Literary Landscape

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Laila Al Sharaqi

2016-08-01

Full Text Available Twitter, synonymous with social networking, has become a successful social platform for the exchange of ideas, news, and information. It has also emerged as an experimental platform through which users explore creative realms of poetic and narrative content, albeit in 140 characters. The real-time tweets are fundamentally unique and increasingly sophisticated. The attention deficit generation of the fast-paced contemporary world has little time on its hands for extended discourse. Brief stories have been told throughout human history, however, the popularity of short stories skyrocketed with the advent of digital story telling. Twitter has now become a frontier medium that allows a unique mode of digital storytelling that facilitates creative literary experimentation. Twitter offers a unique freedom to writers insofar as a tweet can be an entire bite-sized story or even a snapshot of a story that requires readers’ active imagination to complete. Twitter fiction signifies stylistic word economy, compactness, symbolic structure, and implied narrative. Fragmentariness of the story is a marker of Twitter fiction. The proponents of Twitter fiction enjoy the originality, freedom, and diversity of perspectives offered by the Twitter fiction. Critics, however, argue that the mandated 140 character limitation stunts story development and strangulates creativity. This paper examines Twitter fiction and proposes that limited characters stories are the evolutionary answer to the reduced attention span of the tech-savvy generation. Keywords: twitterature, fiction, brevity, literary art

Poetry in Transmedial Perspective: Rethinking Intermedial Literary Studies in the Digital Age

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Schaefer Heike

2015-08-01

Full Text Available In the digital age. literary practice proliferates across different media platforms. Contemporary literary texts are written, circulated and rea|d in a variety of media, ranging from traditional print formats to online environments. This essay explores the implications that the transmedial dispersal of literary culture has for intermedial literary studies. If literature no longer functions as a unified single medium (if it ever did but unfolds in a multiplicity of media, concepts central to intermediality studies, such as media specificity, media boundaries and media change, have to be reconsidered. Taking as its test case the adaptation of E. E. Cummings’s experimental poetry in Alison Clifford’s new media artwork The Sweet Old Etcetera as well as in YouTube clips, the essay argues for a reconceptualization of contemporary literature as a transmedial configuration or network. Rather than think of literature as a single self-contained medium that engages in intermedial exchange and competition with other media, such as film or music, we can better understand how literature operates and develops in the digital age if we recognize the medial heterogeneity and transmedial distribution of literary practice.

Sherlock Holmes: From literary character to pop culture symbol

OpenAIRE

HULCOVÁ, Anna

2013-01-01

The bachelor thesis Sherlock Holmes: From literary character to pop culture symbol deals with the collection of sixty detective stories by Arthur Conan Doyle, the canon. The aim of the thesis is to highlight the aspects that contributed to the popularity of Sherlock Holmes and the series as such. The character of Sherlock Holmes became one of the most adapted literary characters, which is reflected in many areas of popular culture. Special attention is paid to the recent adaptations presentin...

The Viability of Literary Texts.

Science.gov (United States)

Gambone, Kenneth Felix

This study explored whether or not there was an increase in understanding from one literary genre to another, whether or not this growth was apparent from one grade level to another, and whether the growth followed Northrop Frye's suggestion of order: romance, comedy, tragedy, and satire. The high school subjects were asked to read "Merchant of…

The differential proliferative ability of satellite cells in Lantang and Landrace pigs.

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Xiu-qi Wang

Full Text Available Here, for the first time, we evaluate the hypothesis that the proliferative abilities of satellite cells (SCs isolated from Lantang (indigenous Chinese pigs and Landrace pigs, which differ in muscle characteristics, are different. SCs were isolated from the longissimus dorsi muscle of neonatal Lantang and Landrace pigs. Proliferative ability was estimated by the count and proliferative activity of viable cells using a hemocytometer and MTT assay at different time points after seeding, respectively. Cell cycle information was detected by flow cytometry. Results showed that there was a greater (P<0.05 number of SCs in Lantang pigs compared with Landrace pigs after 72 h of culture. The percentage of cell population in S phase and G(2/M phases in Lantang pigs were higher (P<0.05, while in G(0/G(1 phase was lower (P<0.05 in comparison with the Landrace pigs. The mRNA abundances of MyoD, Myf5, myogenin and Pax7 in SCs from Lantang pigs were higher (P<0.05, while those of myostatin, Smad3 and genes in the mammalian target of rapamycin (mTOR pathway (with the exception of 4EBP1 were lower (P<0.05 than the Landrace pigs. Protein levels of MyoD, myogenin, myostatin, S6K, phosphorylated mTOR and phosphorylated eIF4E were consistent with the corresponding mRNA abundance. Collectively, these findings suggested that SCs in the two breeds present different proliferative abilities, and the proliferative potential of SCs in Lantang pigs is higher than in Landrace pigs.

PRACTICE OF USING DIFFERENT WAYS OF ANALYSIS OF A FICTION WORK AT LITERARY READING LESSONS

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Valeriy Syrotenko; Olena Bondarenko

2017-01-01

Analysis of a fiction work at school, in particular in primary school, is based on the methodological studies of the literary analysis, that envisages application of various ways of analysis of a literary text used for the adequate appreciation of its semantic and expressive features. This article is devoted exactly to this range of problems. Literary reading lessons in 2-4th forms set a task of forming schoolchildren’s literary competence, the integral part of which is their ability to an...

El pensament lingüístico-literari de Teodor Llorente

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Vicent Salvador

2015-11-01

Full Text Available The literary-linguistic thought of the father of the Renaixença in Valencia (his conception of the socio­linguistic functions of Catalan, his vision of the unity of the language, his assessment of the various literary genre, etc. forms a coherent system and can be explained by class interests which brought the Renaixença and its modernizing perspectives to a halt in Valencia.

Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon

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Jan Tauchen

Full Text Available ABSTRACT Among 23 extracts of medicinal and edible plants tested, Mauritia flexuosa L.f., Arecaceae, showed significant antioxidant ability (DPPH and ORAC = 1062.9 and 645.9 ± 51.4 µg TE/mg extract, respectively, while Annona montana Macfad., Annonaceae, demonstrated the most promising anti-proliferative effect (IC50 for Hep-G2 and HT-29 = 2.7 and 9.0 µg/ml, respectively. However, combinatory antioxidant/anti-proliferative effect was only detected in Oenocarpus bataua Mart., Arecaceae (DPPH = 903.8 and ORAC = 1024 µg TE/mg extract; IC50 for Hep-G2 and HT-29 at 102.6 and 38.8 µg/ml, respectively and Inga edulis Mart., Fabaceae (DPPH = 337.0 and ORAC = 795.7 µg TE/mg extract; IC50 for Hep-G2 and HT-29 at 36.3 and 57.9 µg/ml, respectively. Phenolic content was positively correlated with antioxidant potential, however not with anti-proliferative effect. None of these extracts possessed toxicity towards normal foetal lung cells, suggesting their possible use in development of novel plant-based agents with preventive and/or therapeutic action against oxidative stress-related diseases.

The Actualization of Literary Learning Model Based on Verbal-Linguistic Intelligence

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Nur Ihsan Halil

2017-10-01

Full Text Available This article is inspired by Howard Gardner's concept of linguistic intelligence and also from some authors' previous writings. All of them became the authors' reference in developing ideas on constructing a literary learning model based on linguistic intelligence. The writing of this article is not done by collecting data empirically, but by developing and constructing an existing concept, namely the concept of linguistic intelligence, which is disseminated into a literature-based learning of verbal-linguistic intelligence. The purpose of this paper is to answer the question of how to apply the literary learning model based on the verbal-linguistic intelligence. Then, regarding Gardner's concept, the author formulated a literary learning model based on the verbal-linguistic intelligence through a story-telling learning model with five steps namely arguing, discussing, interpreting, speaking, and writing about literary works. In short, the writer draw a conclusion that learning-based models of verbal-linguistic intelligence can be designed with attention into five components namely (1 definition, (2 characteristics, (3 teaching strategy, (4 final learning outcomes, and (5 figures.

Literary Aesthetics in the Narration of Dagara Folktales

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Martin Kyiileyang

2016-12-01

Full Text Available Dagara folktales, like other African folktales, are embedded with various literary aesthetic features related to structure, language and performance. This paper examines major literary aesthetics found in Dagara folktales. The methodology used is based on the collection, analysis and interpretation of selected Dagara folktales gathered through fieldwork. The focus of the paper is on the structure and the language of Dagara folktales. The argument of this paper is grounded on the Structuralist Theory as seen in Gerard Genette’s Narrative Discourse which offers the basic constituents and techniques of narrative. Genette proposes various categories of narrative which cover Time, Mood and Voice. Genette’s narrative structure suggests that the various categories and subcategories emphasise that the narrative is a complex structure in which the narratee is largely present in the various strata of the structure. Genette is concerned with the macro-text of the recit, that is, the ordering of events in the narrative. The study revealed that there are similarities and differences in the structure and the language of Dagara folktales in relation to other African folktales. Keywords: Dagara People, Folktale, Literary Aesthetics, Performance, Structuralist Theory

REVIEW: ORAL AND LITERARY CONTINUITIES IN MODERN TIBETAN LITERATURE: THE INESCAPABLE NATION

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Reviewed by Séagh Kehoe

2018-05-01

Full Text Available Oral and Literary Continuities in Modern Tibet: The Inescapable Nation, Lama Jabb's contribution to Studies in Modern Tibetan Culture series, is the first book-length study in English to center the literary, cultural, and political roots of modern Tibetan literature. Written by Lama Jabb, born and raised in a herding community in Amdo and now a junior research fellow in Tibetan and Himalayan Studies at the University of Oxford, this ambitious landmark study offers an in-depth and meticulously researched examination of the persistence of Tibet's artistic and oral traditions in the literary creativity of the present. Spanning a wide-range of oral and literary texts, the book also draws attention to the deep and untiring concern for the Tibetan nation across modern Tibetan writing. The book is neatly organized into seven chapters, along with acknowledgements, an extensive bibliography, index, and short biography of Lama Jabb himself. In 277 pages, it moves gracefully across a diverse and skillfully interwoven set of discussions of Tibetan music, the Tibetan tradition of social criticism, cultural traumas, the Third Generation of Tibetan poets, and contemporary Tibetan erotic poetry, all the while spotlighting literary legacies and the persistent preoccupation for with the Tibetan nation in modern Tibetan literature. ...

A selection of Slovenian literary heroes for the preschool period

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Dolinar, Ana

2014-01-01

In preschools, Slovenian literary heroes are being displaced by foreign fantastic heroes that impress children via cartoons, magazines and video games. Slovenian heroes are an important part of our culture and can act as companions of sorts within citizenship education of youngsters. This thesis should serve as a promotion of Slovenian literary heroes for children of all ages, beginning with the preschool period. The thesis defines the selection criterion of characters; it introduces their st...

Antibacterial, antioxidant and cell proliferative properties of Coccinia grandis fruits

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Prashant Sakharkar

2017-06-01

Full Text Available Objective: Little knowledge is available on the antimicrobial and antioxidant properties of Coccina grandis fruits and no study has reported on its cell proliferative property. The aim of this study was to examine the antimicrobial, antioxidant and cell proliferative property of fruits of C. grandis. Material and Methods: Fruits of C. grandis were extracted using water; ethanol and acetone by cold and hot Soxhlet extraction. The antibacterial activities of the extracts were tested against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Pseudomonas aeruginosa using the modified Kirby-Bauer diffusion method and compared against erythromycin. The antioxidant property was determined using Cayman's antioxidant assay; whereas cell proliferation/cytotoxic properties were evaluated using the Cell Titer 96 Aqueous One Solution Cell MTS assay with MDA-MB 321 breast cancer cells. Data were analyzed for correlation and differences using unpaired student's t-test and one-way ANOVA. A p value of Results: Both cold and hot ethanol and acetone extracts of C. grandis fruits showed some degree of bacterial growth inhibition. Acetone extracts exhibited higher antibacterial activity. Both ethanol extracts showed antioxidant property when compared with standard Trolox. In contrary to cytotoxicity, all four extracts showed cell proliferation compared to controls at different concentrations. However, acetone extracts exhibited greater cell proliferation compared to ethanol extracts and cold extracts performed better than the hot extracts. Conclusion: C. grandis fruits exhibited some degree of antimicrobial, antioxidant and cell proliferative properties. Further investigation is warranted to isolate, confirm and characterize phytochemicals that are responsible for the medicinal properties observed.

A Classification Scheme for Literary Characters

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Matthew Berry

2017-10-01

Full Text Available There is no established classification scheme for literary characters in narrative theory short of generic categories like protagonist vs. antagonist or round vs. flat. This is so despite the ubiquity of stock characters that recur across media, cultures, and historical time periods. We present here a proposal of a systematic psychological scheme for classifying characters from the literary and dramatic fields based on a modification of the Thomas-Kilmann (TK Conflict Mode Instrument used in applied studies of personality. The TK scheme classifies personality along the two orthogonal dimensions of assertiveness and cooperativeness. To examine the validity of a modified version of this scheme, we had 142 participants provide personality ratings for 40 characters using two of the Big Five personality traits as well as assertiveness and cooperativeness from the TK scheme. The results showed that assertiveness and cooperativeness were orthogonal dimensions, thereby supporting the validity of using a modified version of TK’s two-dimensional scheme for classifying characters.

On the reception of a literary work

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Jacek Wachowski

2018-05-01

Full Text Available The article is an attempt to answer the question: what happens to a literary work – understood as Ingarden’s purely intentional objects – from the recipient’s perspective? And also: how do the images of objects arise in the minds of the audience and what are their properties? Transferring purely intentional objects to the recipient’s perspective changes their status: mental images of objects are subject to numerous fluctuations (based on emotions and cognitive processes. In this way they are transformed into forms that are non-permanent reflections of objects belonging to a literary work. Referring to Ingarden’s terminology, one might say that they become purely intentional reflections (or reflections of purely intentional objects. The article is an attempt to characterize and stratify them.

Literary ethnographic writing as sympathetic experiment

DEFF Research Database (Denmark)

Dalsgaard, Anne Line

perhaps only implicitly) of research. But we have no direct access to the subjective world of others and can only inhabit their point of view by way of imagination. Writing literary ethnographic text is one way, I will argue, of experimenting with such sympathetic imagination. By putting together observed...

Some considerations about literary analysis modern methods from a didactic perspective

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Marialina Ana García Escobio

2016-12-01

Full Text Available This article make it possible a close look to the modern methods of literary analysis, taking as the starting point what the teaching of literature in the joyful context should fulfill in the study of the literary play and the processes of reception and aesthetic statement, as well as the application of the aforementioned methods in the attempt to make the student arrive at rational position; But, at the same time, he/she should feel creator and coauthor of an event that should be lived from a type of special reading done; Herein the importance of a system of methodological work that prepares the professors to contribute from each of the classes to the development of skills for the students´ literary analysis.

Literary Voices in Dubliners

OpenAIRE

Duech, Lorie-Anne

2017-01-01

Critics have already pointed out the importance of Joyce's use of quotation, allusion and parody, especially in his later work. The names of Flaubert, Oscar Wilde and Shakespeare have long been associated with Joyce's writing. This is the type of literary association that places Joyce within "tradition" and "the historical sense" which involves, as T.S. Eliot explains, "a perception, not only of the pastness of the past, but of its presence." Joyce's use of subtexts not only reveals his tende...

The Literary Legacy Inherited by Ankara of the Republican Era: Literary Life and Milieux in Ankara until the Republic Era

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Necati Tonga

2014-12-01

Full Text Available Ankara became one of the most important circles of literary activities after the establishment of the Republic of Turkey in 1923. In this era, the most prevalent factor for this nourishment was that Ankara was chosen as the capital city and Turkey would be governed from Ankara from then on. Besides this fact, before being the capital, Ankara had a rich background in terms of literature. The city had a strong tradition of Divan and Sufi literature in the ruling periods of Seljuks and Ottomans. Many Divan poets and minstrels lived in Ankara throughout history. In those times, in addition to madrasahs, dervish lodges and mosques, there were taverns, inns, mansions, coffeehouses, vineyards and gardens that were used for gatherings where poems were recited and talks about literature took place. Before the establishment of the Republic, in the years between 1919 and 1922, Mustafa Kemal Atatürk proclaimed Ankara as the headquarters of the national movements. This choice brought out a liveliness to Ankara in terms of literature. In this period until the Republic, many places serving as dervish lodges, coffeehouses, restaurants, gardens, taverns, and shops, and newspaper editorials such as Tâceddin Dergâhı (Taceddin’s Lodge, Kuyulu Kahve (Coffee-shop, Merkez Kıraathanesi (Central coffee-shop, Hakimiyet-i Milliye and Yenigün Newspaper Editorial Offices, Anadolu Lokantası (Anadolu Restaurant, Teceddüt Lokantası (Teceddüt Restaurant, Abdullah Efendi Lokantası (Abdullah Efendi Restaurant, Muallimler Birliği (Teachers Union, Şehir Bahçesi (City Garden, Dayko’nun Tütüncü Dükkânı (Dayko’s Tobacco Shop and Efe Haydar’ın Meyhanesi (Efe Haydar’s Tavern were prominent gathering places that flourished in the literary activities of Ankara.

Proliferative activity in oral pyogenic granuloma: A comparative immunohistochemical study

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Rezvani Gita

2010-07-01

Full Text Available Context: Pyogenic granuloma (PG is one of the most common reactive vascular lesions in the oral mucosa, which has been divided into the lobular capillary hemangioma (LCH and the non lobular type (non-LCH as two distinct entities, on the basis of some investigations. Aims: This study aims to compare the proliferative and angiogenic activity of two histological types of PG to determine whether they have two distinct types of biological behavior. Settings and Design: In this retrospective cross-sectional study, immunostaining was performed on 10 cases of each type of PG. Materials and Methods: About 4μm sections were cut from formalin-fixed paraffin-embedded blocks and each specimen was stained with both anti-CD31 and anti-Ki-67 antibodies simultaneously. Labeling index (LI was determined for both types by counting Ki-67 and CD31 positive cells separately and simultaneously in 1000 stromal and luminal cells. Micro vessel count (MVC, the mean number of micro vessels in five areas at Χ200 magnification, was also determined for both groups. Statistical Analysis: The results were statistically compared using the Mann-Whitney U-test. Results: Ki-67 LI in LCH (5.4 ± 2.4 was higher than non-LCH (3.9 ± 3.9. The percentage of CD31 positive cells in LCH (28.5 ± 22 was lower than non-LCH (37.1 ± 20.8 and simultaneously immunostaining for both markers in LCH type (2.4 ± 2.1 was higher than non-LCH (1.2 ± 1. The MVC was approximately 77.35 ± 34.6 and 82.6 ± 42.7 in the lobular areas of LCH and central areas of non-LCH PG, respectively. These differences were not statistically significant. Conclusions: These results demonstrate a higher proliferation activity in endothelial cells of LCH PG than in non-LCH.

Ethnic boundaries in American, Dutch and German national literary policies, 1965-2005

NARCIS (Netherlands)

P.P.L. Berkers (Pauwke)

2009-01-01

textabstractThis article addresses the extent and ways in which ethnic diversity has been part of American, Dutch and German national literary policy from 1965 until 2005. By analyzing the content of policy documents of the National Endowment of the Arts and the Dutch and German Literary Fund, I

LITERARY DEBATES IN THE ROMANIA’S NINETIES CONSEQUENCES AND ASSESSMENTS

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Lucian CHIȘU

2016-11-01

Full Text Available Social systems undergo inevitable turning points in their evolution. These changes may be caused by either progressive accumulation or a major crisis. The latter applies to Romania, who - after being a communist country - grew into a democracy as a result of a popular uprising. The dictatorship and its effects became the favourite topic of discussion in many debates - political, economic, social, or cultural - whose protagonists asserted their various opinions in the name of democracy or general usefulness. The participation in these debates was also exceptional – from well-meaning but resentful people, lucid and/or visionaries, to crypto-communists, apocalyptic and even alienated people. That explains the absence of consensus. The respective period of time was coined as “an endless transition”, a term which covered all the masked avatars of Romanian society (and of the literary phenomenon, too. Confrontations were particularly illustrative within the printed media in the field of culture, which beside tackling the general problems also focused on specific guild issues: the repercussions of the dictatorship on literary life, the writer’s status, the effects of censorship and the freedom of expression, the ethical and moral criteria, the literary canon, the future of publishing houses and literary publications, the very existence of the Writers’ Union of Romania, the literary exile and the ‘inner exile’ (of writers from the Republic of Moldova. The topics above polarized differently, in opposite directions, which could be summarized as follows: in our country, culture was as a form of resistance during communism when Romania was ‘a Siberia of the spirit’. The passing of a quarter of a century from the 1989 popular uprising now facilitates a retrospective overview of those particular times.

Proliferative, necrotizing and crescentic immune complex-mediated glomerulonephritis in a cat

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Carolyn Gross

2015-09-01

Full Text Available Case Summary A 5-year-old cat was examined for vomiting and anorexia of 2 days’ duration. Azotemia, hyperphosphatemia and hypoalbuminemia were the main biochemical findings. Serial analyses of the urine revealed isosthenuria, proteinuria and eventual glucosuria. Hyperechoic perirenal fat was detected surrounding the right kidney by ultrasonography. Histopathologic evaluation of ante-mortem ultrasound-guided needle biopsies of the right kidney was consistent with proliferative, necrotizing and crescentic glomerulonephritis with fibrin thrombi, proteinaceous and red blood cell casts, and moderate multifocal chronic-active interstitial nephritis. Owing to a lack of clinical improvement, the cat was eventually euthanized. Post-mortem renal biopsies were processed for light microscopy, transmission electron microscopy and immunofluorescence. This revealed severe focal proliferative and necrotizing glomerulonephritis with cellular crescent formation, podocyte injury and secondary segmental sclerosis. Ultrastructural analysis revealed scattered electron-dense deposits in the mesangium, and immunofluorescence demonstrated positive granular staining for λ light chains, consistent with immune complex-mediated glomerulonephritis. Severe diffuse acute tubular epithelial injury and numerous red blood cell casts were also seen. Relevance and novel information To our knowledge, this is the first report of naturally occurring proliferative, necrotizing and crescentic immune complex glomerulonephritis in a cat.

DIAGNOSTIC CRITERIA FOR PROLIFERATIVE THYROID LESIONS IN BONY FISHES

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Thyroid proliferative lesions are rather common in bony fishes but disagreement exists in the fish pathology community concerning diagnostic criteria for hyperplastic versus neoplastic lesions. To simplify the diagnosis of proliferative thyroid lesions and to reduce confusion reg...

Literary text reading and conversation: beyond ethnomethodology boundaries

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Viviana Suárez Galvis

2014-01-01

Full Text Available This article leaves aside ethnomethodological approaches to conversation, and aims at opening the debate about the need of conceiving it under the light of pedagogical principles that position it as a propitious discursive gender to express the emotional, aesthetics, thoughtful, and intellectual meetings embodied while reading literary texts. Such interest arose from a research centered on finding the existing relationships between conversation and construction of aesthetical-literary experiences. The results show that students get a pleasant feeling when giving sense to what they read, and this encourages them to share with others their significant experiences when reading, allowing the internal process of meaning construction and the dialogic strengthening of the experiences to be connected.

The prognostic value of oncogenic antigen 519 (OA-519) expression and proliferative activity detected by antibody MIB-1 in node-negative breast cancer

DEFF Research Database (Denmark)

Jensen, V; Ladekarl, M; Holm-Nielsen, P

1995-01-01

of invasion of skin or deep fascia (= T1N0M0 and T2N0M0). The median follow-up time was 104 months (range 5-143 months). Immunohistochemical analysis of OA-519 expression was performed on formalin-fixed, paraffin-embedded tissue. The proliferative activity was estimated using a Ki-67 equivalent monoclonal...

The Meaning and Significance of Contemporary Media in Collecting and Studying Croatian Oral Literary Heritage

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Vanda Babić

2013-05-01

Full Text Available In the study of Croatian oral literary heritage, great importance present the records that have remained preserved as notes on documents, books, songs and poems as part of literary works. Records shows that oral literary text is the subject of research and study of oral heritage. However, the records themselves are not sufficient for studying oral literary text and its context. The text is accompanied by a recorded voice that faithfully represents the diction, rhythm, tone and color of the narrator voice. Videos shows the gestures, context and emotion of the narrator. Without the role of the modern media, oral literary records would be insufficient for studying fundamental aspects of communicativeness that can be interpreted as a context. The media of public communication greatly affects the expansion of the basic ideas of the oral transmission of text which is - storytelling.

Features of Aestheticism in Literary Heritage of Mikhail Kuzmin

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Elena Kolmykova

2015-08-01

Full Text Available The article deals with the main principles of aestheticism reflected in the literary works of Mikhail Kuzmin, the author of well-known lines: “Широки и спокойны струи, Как судоходный Дунай!” The sources of M. Kuzmin’s aestheticism, such as ideas of Pre-Raphaelites, French symbolists, English aesthetes are under investigation. It is stated that literary heritage of Oscar Wilde greatly influenced M. Kuzmin’s critical works.

Proliferative and non-proliferative lesions of the rat and mouse integument.

Science.gov (United States)

Mecklenburg, Lars; Kusewitt, Donna; Kolly, Carine; Treumann, Silke; Adams, E Terence; Diegel, Kelly; Yamate, Jyoji; Kaufmann, Wolfgang; Müller, Susanne; Danilenko, Dimitry; Bradley, Alys

2013-01-01

The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) project is a joint initiative of the societies of toxicological pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP). Its aim is to develop an internationally-accepted nomenclature for proliferative and non-proliferative lesions in laboratory rodents. A widely accepted international harmonization of nomenclature in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and will provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists. The purpose of this publication is to provide a standardized nomenclature for classifying microscopical lesions observed in the integument of laboratory rats and mice. Example colour images are provided for most lesions. The standardized nomenclature presented in this document and additional colour images are also available electronically at http://www.goreni.org. The nomenclature presented herein is based on histopathology databases from government, academia, and industrial laboratories throughout the world, and covers lesions that develop spontaneously as well as those induced by exposure to various test materials. (DOI: 10.1293/tox.26.27S; J Toxicol Pathol 2013; 26: 27S-57S).

Problems of Kazakh Literary Criticism Formation

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Zhandos Smagulov

2013-01-01

Full Text Available Тhe article is concerned with the problem of scientific research of Kazakh literature formation in national science. Kazakh literature, having long history of formation is classified by periods. Besides, the article thoroughly considers the principles of the study of methodology, theory, history of spiritual heritage in Kazakh literary criticism

Biocatalytically Oligomerized Epicatechin with Potent and Specific Anti-proliferative Activity for Human Breast Cancer Cells

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Ramaswamy Nagarajan

2008-11-01

Full Text Available Catechins, naturally occurring flavonoids derived from wine and green tea, are known to exhibit multiple health benefits. Epigallocatechin gallate (EGCG is one of the most widely investigated catechins, but its efficacy in cancer therapy is still inconsistent and limited. The poor stability of EGCG has contributed to the disparity in the reported anti-cancer activity and other beneficial properties. Here we report an innovative enzymatic strategy for the oligomerization of catechins (specifically epicatechin that yields stable, water-soluble oligomerized epicatechins with enhanced and highly specific anti-proliferative activity for human breast cancer cells. This one-pot oxidative oligomerization is carried out in ambient conditions using Horseradish Peroxidase (HRP as a catalyst yielding water-soluble oligo(epicatechins. The oligomerized epicatechins obtained exhibit excellent growth inhibitory effects against human breast cancer cells with greater specificity towards growth-inhibiting cancer cells as opposed to normal cells, achieving a high therapeutic differential. Our studies indicate that water-soluble oligomeric epicatechins surpass EGCG in stability, selectivity and efficacy at lower doses.

An Afropolitan literary aesthetics?

DEFF Research Database (Denmark)

Rahbek, Ulla; Knudsen, Eva Rask

2017-01-01

This article discusses what the authors call an emerging Afropolitan aesthetics. Through an exploration of recurring stylistic features, the article focuses particularly on the trope of a mobility-induced anxiety that entwines place and self. The ontological and affective troping of return...... and of self-understanding and the contemporary signification of Africa as a complex place of relocation and reconnection are explored in discussions of literary characters in Taiye Selasi’s Ghana Must Go (2013), Yvonne Owuor’s Dust (2014), Sefi Atta’s A Bit of Difference (2013) and Chimamanda Ngozi Adichie...

Marginalia. The Literary Independence of Spanish America

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Juan Guillermo Gómez García

2010-12-01

Full Text Available This article discusses some of the characteristic problems and issues of the so-called “literary independence” of Spanish America in the light of its political emancipation from Spain. This topic goes beyond the temporal framework or the periodization of the wars of independence; instead, it covers the entire nineteenth century and part of the twentieth, and appears discontinuously and non-simultaneously in the different nations. The path followed by Spanish American literature was filled with vicissitudes,manifestations, and regressions of diverse types. The paper specifically analyzes La biblioteca americana and El repertorio americano by the Venezuelan, Andrés Bello, and Juan García del Río, a native of Cartagena, as well as the role of the young Argentinean Domingo F. Sarmiento, author of Facundo, in the genesis and first outlines of an independent Spanish American “literary expression”.

A canonical-literary reading of Lamentations 5

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Shinman Kang

2009-08-01

Full Text Available This article presents a canonical and literary reading of Lamentations 5 in the context of the book of Lamentations as a whole. Following the approach by Vanhoozer (1998, 2002 based on speech-act theory, the meaning of Scripture is sought at canonical level, supervening the basic literary level. In Lamentations, as polyphonic poetic text, the speaking voices form a very important key for the interpretation of the text. In the polyphonic text of Lamentations, the shifting of the speaking voices occurs between Lamentations 1 and 4. Lamentations 5 is monologic. The theories of Bakhtin (1984 are also used to understand the book of Lamentations. In this book, chapter 5 forms the climax where Jerusalem cries to God. We cannot, however, find God’s answer to this call in Lamentations; we can find it only within the broader text of the Christian canon.

The Inter-Semiotic Negotiation between the Literary and the Cinematographic Image

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Carmen DOMINTE

2015-07-01

Full Text Available Considering the postmodern perspective, a text or a discourse never ends, but continues in other texts and discourses. Besides the physical limits, any literary text or discourse develops in a literary system of references belonging to other texts or discourses. The concept of inter-semiotic negotiation describes the process of inter-action realized between two semiotic systems and shows that the meaning generated from one system can be transposed into another semiotic system and, even more, from the writer to the reader, and even further, from the director to the spectator, but mediated through different types of codes. Transferring the aesthetic meaning from one form of art (literature to another (cinematography, there are specific changes for the artistic manner of performance and reception but the common element that may link both arts is represented by the image: literary and cinematographic.

The evolution of conceptions about space and time in literary theory

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Lazić Nebojša J.

2012-01-01

Full Text Available This work considers the function of space and time in poetics of literary text from the antique period till the theory of deconstruction as well as from Aristotle till Jacques Derrida and Paul de Man. The science of literature did not equally treat the problem of space and the problem of time as the elements of the literary work's structure. Disbalance presents the damage of studying the space because there is a significant number of monographs about time. Since the categories of space and time are the areas of studying physical and spiritual sciences, it was necessary to pay attention to considering these questions in exact sciences such as Physics, Maths etc. Further development of the science of literature is not possible without describing the role of space and time in writing and shaping a literary text. .

Literary Translation and Cultural Challenges: JhumpaLahiri's The Namesake

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Sura M. Khrais

2017-01-01

Full Text Available This paper discusses how the nature of literary translation differs from other forms of translation by looking at practical difficulties and challenges notable in the Arabic translation of Lahiri's novel The Namesake (2003. The difficulties discussed are cultural differences which have created “untranslatable” cultural-bound words and phrases, as well as specialized vocabulary. The paper explores the conflict between the translator's duty to accuracy and his/her duty to literary translation as an art form. One problem faced by the prose-translator is finding terms in his or her own language that are faithful as much as possible to the meaning of certain words in S.L. For example, there are words which describe specific rituals or those related to typical architecture, fabrics, and cookery; these and many others represent the specific culture of the original text and the translator needs to be careful when translating them. The researcher finally suggests that there is a need to expand the perimeters of  translation studies specially those dealing with literary prose because the translators and researchers lay more emphasis on the translation of poetry.

Kirjanduslikest kontaktidest läbi raudse eesriide / Literary contacts through the iron curtain

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Marin Laak

2016-09-01

Full Text Available The article deals with the relationship between the literature of the Estonian diaspora in the West and Soviet Estonia during the 1960s, and explores the possibility, from the literary historiographical perspective, of integrating the two bodies of Estonian literature. Near the end of The Second World War close to 70,000 Estonians fled their homeland, fearing Soviet repression; among them were numerous members of the academic and artistic intelligentsia as well as eminent poets and writers. By the late 1940s national organizations, publications and other activities were already well underway in the displaced persons camps. During the 1950s, Estonian exiles who settled in Sweden, Canada, United States, and elsewhere in the West quickly formed national cultural centres, publishing houses and numerous organizations that helped maintain their national and cultural identity. The centre of literary activity in the West was Sweden, which most Estonian writers had chosen as their new home. The Estonian Writers’s Co-operative publishing house, established in Lund in 1950, started the mail-order distribution of Estonian literature throughout the world; elsewhere, the publisher Orto operated in Toronto. While no propaganda-free literature or literature of any artistic merit was published in the 1940s and 1950s in Estonia during the Soviet occupation, exile literature flourished. Then, the Khrushchev Thaw brought about changes to Soviet society in the late 1950s. As their world became more free, a new generation of talented young poets emerged who generated innovations in poetry and modernized literature. This article maps literary contacts between the Estonian homeland and her exiles, and, using archival material, focuses on personal contacts among the literati during the 1960s. Literary historiography began investigating the possibility of treating Estonian literature in the homeland and in the West as one body of literature, when, after a 45-year

Synthesis and Anti-Proliferative Effects of Mono- and Bis-Purinomimetics Targeting Kinases

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Andrea Bistrović

2017-11-01

Full Text Available A series of mono-pyrrolo[2,3-d]pyrimidines 4a–4k, unsymmetrical bis-purine isosteres 5a–5e and symmetrical bis-pyrrolo[2,3-d]pyrimidines 6a and 6b connected via di(1,2,3-triazolylphenyl linker were synthesized by click chemistry. Whereas mono- 4g and bis-pseudopurine 5e showed selective inhibitory activities on cervical carcinoma (HeLa cells, bis-pyrrolo[2,3-d]pyrimidine 6b exhibited potent and selective anti-proliferative effect in the nanomolar range on pancreatic carcinoma (CFPAC-1 cells. Among these, compound 6b induced a significant reduction in the expression level of CDK9 (cyclin-dependent kinase 9/cyclin T1 in CFPAC-1 cells concomitant with attenuation of proliferative signaling mediated by c-Raf (rapidly accelerated fibrosarcoma and p38 MAP (mitogen-activated protein kinases. Our findings encourage further development of novel structurally related analog of 6b to obtain more selective anticancer agent for treating pancreatic cancer.

TU-F-12A-02: Quantitative Characterization of Normal Bone Marrow Proliferative Activity with FLT PET/CT

Energy Technology Data Exchange (ETDEWEB)

Weisse, N; Jeraj, R [Department of Medical Physics, University of Wisconsin, Madison, WI (United States)

2014-06-15

Purpose: [F-18]FLT PET is a tool for assessing health of bone marrow by evaluating its proliferative activity. This study establishes a baseline quantitative characterization of healthy marrow proliferation to aid in diagnosis of hematological disease. Methods: 31 patients (20 male, 11 female, 41–76 years) being treated for solid cancers with no history of hematological disease, osseous metastatic disease, or radiation therapy received pre-treatment FLT PET/CT scans. Total bone marrow was isolated from whole body FLT PET images by manually removing organs and applying a standardize uptake value (SUV) threshold of 1.0. Because adult marrow is concentrated in the axial skeleton, quantitative total bone marrow analysis (QTBMA) was used to isolate marrow in the lumbar spine, thoracic spine, sacrum, and pelvis for analysis. SUV_mean, SUV_max, and SUV_CV were used to quantify bone marrow proliferation. Correlations were explored between SUV and patient characteristics including age, weight, height, and BMI using the Spearman coefficient (ρ). Results: The population-averaged whole-skeleton SUV_mean, SUV_max, and SUV_CV were 3.0±0.6, 18.4±5.7, and 0.6±0.1, respectively. Uptake values in the axial skeleton were similar to the whole-skeleton demonstrated by SUV_mean in the thoracic spine (3.6±0.6), lumbar spine (3.3±0.5), sacrum (3.0±0.6), and pelvis regions (2.8±0.5). Whole-skeleton SUV_max correlated with patient weight (ρ=0.47, p<0.01) and BMI (ρ=0.60, p<0.01), suggesting marrow activity is related to the body's burden. SUV measures in the thoracic spine, lumbar spine, sacrum, and pelvis were negatively correlated with age (ρ:−0.41 to −0.46, p≤0.02). These negative correlations reflect the fact that active marrow in the adult skeleton is localized in the axial skeleton and decreases with age. Conclusions: Normal bone marrow characterizations were determined using FLT

A peroxisome proliferator-activated receptor ligand MCC-555 imparts anti-proliferative response in pancreatic cancer cells by PPARgamma-independent up-regulation of KLF4

Energy Technology Data Exchange (ETDEWEB)

Min, Kyung-Won [Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 (United States); Zhang, Xiaobo [Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 (United States); College of Animal Science and Technology, Northwest A and F University, Yangling, Shaanxi, 712100 (China); Imchen, Temjenmongla [Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 (United States); Baek, Seung Joon, E-mail: sbaek2@utk.edu [Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 (United States)

2012-09-01

MCC-555 is a novel PPARα/γ dual ligand of the thiazolidinedione class and was recently developed as an anti-diabetic drug with unique properties. MCC-555 also has anti-proliferative activity through growth inhibition and apoptosis induction in several cancer cell types. Our group has shown that MCC-555 targets several proteins in colorectal tumorigenesis including nonsteroidal anti-inflammatory drug (NSAID)-activated gene (NAG-1) which plays an important role in chemoprevention responsible for chemopreventive compounds. NAG-1 is a member of the TGF-β superfamily and is involved in tumor progression and development; however, NAG-1's roles in pancreatic cancer have not been studied. In this report, we found that MCC-555 alters not only NAG-1 expression, but also p21 and cyclin D1 expression. NAG-1 and p21 expression was not blocked by PPARγ-specific antagonist GW9662, suggesting that MCC-555-induced NAG-1 and p21 expression is independent of PPARγ activation. However, decreasing cyclin D1 by MCC-555 seems to be affected by PPARγ activation. Further, we found that the GC box located in the NAG-1 promoter play an important role in NAG-1 transactivation by MCC-555. Subsequently, we screened several transcription factors that may bind to the GC box region in the NAG-1 promoter and found that KLF4 potentially binds to this region. Expression of KLF4 precedes NAG-1 and p21 expression in the presence of MCC-555, whereas blocking KLF4 expression using specific KLF4 siRNA showed that both NAG-1 and p21 expression by MCC-555 was blocked. In conclusion, MCC-555's actions on anti-proliferation involve both PPARγ-dependent and -independent pathways, thereby enhancing anti-tumorigenesis in pancreatic cancer cells. -- Highlights: ► PPARα/γ ligand MCC-555 exhibits anti-proliferative activity in pancreatic cancer cells. ► MCC-555 affects KLF4 expression following by NAG-1 and p21 expression in a PPARγ independent manner. ► MCC-555 also affects cyclin D1 down

A peroxisome proliferator-activated receptor ligand MCC-555 imparts anti-proliferative response in pancreatic cancer cells by PPARgamma-independent up-regulation of KLF4

International Nuclear Information System (INIS)

Min, Kyung-Won; Zhang, Xiaobo; Imchen, Temjenmongla; Baek, Seung Joon

2012-01-01

MCC-555 is a novel PPARα/γ dual ligand of the thiazolidinedione class and was recently developed as an anti-diabetic drug with unique properties. MCC-555 also has anti-proliferative activity through growth inhibition and apoptosis induction in several cancer cell types. Our group has shown that MCC-555 targets several proteins in colorectal tumorigenesis including nonsteroidal anti-inflammatory drug (NSAID)-activated gene (NAG-1) which plays an important role in chemoprevention responsible for chemopreventive compounds. NAG-1 is a member of the TGF-β superfamily and is involved in tumor progression and development; however, NAG-1's roles in pancreatic cancer have not been studied. In this report, we found that MCC-555 alters not only NAG-1 expression, but also p21 and cyclin D1 expression. NAG-1 and p21 expression was not blocked by PPARγ-specific antagonist GW9662, suggesting that MCC-555-induced NAG-1 and p21 expression is independent of PPARγ activation. However, decreasing cyclin D1 by MCC-555 seems to be affected by PPARγ activation. Further, we found that the GC box located in the NAG-1 promoter play an important role in NAG-1 transactivation by MCC-555. Subsequently, we screened several transcription factors that may bind to the GC box region in the NAG-1 promoter and found that KLF4 potentially binds to this region. Expression of KLF4 precedes NAG-1 and p21 expression in the presence of MCC-555, whereas blocking KLF4 expression using specific KLF4 siRNA showed that both NAG-1 and p21 expression by MCC-555 was blocked. In conclusion, MCC-555's actions on anti-proliferation involve both PPARγ-dependent and -independent pathways, thereby enhancing anti-tumorigenesis in pancreatic cancer cells. -- Highlights: ► PPARα/γ ligand MCC-555 exhibits anti-proliferative activity in pancreatic cancer cells. ► MCC-555 affects KLF4 expression following by NAG-1 and p21 expression in a PPARγ independent manner. ► MCC-555 also affects cyclin D1 down

78 FR 35642 - Certain TV Programs, Literary Works for TV Production and Episode Guides Pertaining to Same...

Science.gov (United States)

2013-06-13

... INTERNATIONAL TRADE COMMISSION [Docket No 2959] Certain TV Programs, Literary Works for TV... Certain TV Programs, Literary Works for TV Production and Episode Guides Pertaining to Same, DN 2959; the... importation of certain TV programs, literary works for TV production and episode guides pertaining to same...

The prognostic value of oncogenic antigen 519 (OA-519) expression and proliferative activity detected by antibody MIB-1 in node-negative breast cancer

DEFF Research Database (Denmark)

Jensen, V; Ladekarl, M; Holm-Nielsen, P

1995-01-01

The prognostic value of oncogenic antigen 519 (OA-519) expression and tumour proliferative activity was evaluated in a retrospective series of 118 patients with low-risk breast cancer. Low risk was defined as negative axillary nodes, tumour diameter histological evidence...... analysis, both the MIB-1 index and OA-519 expression were of independent prognostic value (2p breast cancer who might benefit from adjuvant therapy....

A comparative study of proliferative activity and tumor stage of pregnancy-associated melanoma (PAM) and non-PAM in gestational age women.

Science.gov (United States)

Merkel, Emily A; Martini, Mary C; Amin, Sapna M; Yélamos, Oriol; Lee, Christina Y; Sholl, Lauren M; Rademaker, Alfred W; Guitart, Joan; Gerami, Pedram

2016-01-01

The influence of pregnancy on the development, progression, and prognosis of melanoma is controversial. We sought to compare clinical characteristics, histologic features, and proliferative activity in pregnancy-associated melanoma (PAM) and melanoma in nonpregnant women of reproductive age (non-PAM). In this retrospective cohort study, we reviewed medical records and pathology reports from women given a diagnosis of melanoma between 2006 and 2015. We also examined tumor proliferation rates using mitotic count and 2 immunohistochemical markers of proliferation, phosphohistone H3 and Ki-67. In 50 PAM and 122 non-PAM cases, a diagnosis of melanoma in situ was associated with PAM. Among invasive melanomas, there was no difference in proliferative activity between groups. Pregnancy status was also not associated with age at diagnosis, tumor site, Breslow depth, Clark level, ulceration, or overall stage. This was a retrospective study with a small sample size of mostly patients with early-stage melanoma. In our study of primarily early-stage melanoma, pregnancy did not have a significant impact on tumor proliferation. Particularly for patients given a diagnosis of stage I melanoma who are undergoing close surveillance, a history of PAM should not outweigh traditional factors, such as advanced maternal age, in planning future pregnancies. Copyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

CULTURAL NATIONALISM AND THE IRISH LITERARY REVIVAL

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David Pierce

2002-12-01

Full Text Available The impact of cultural nationalism on the Insh Literary Revival is a topic of continuing interest for the cultural critic and literary historian alike. In recent years, with the Fa11 of the Berlin Wall, political scientists and others, suchas A.D. Smith, Ernest Gellner, and E.J. Hobsbawm, have also focused on the subject of nationalism. The intention here in this article is to revisit a familiar site in the light of these new ideas and to test their validity or appropriateness in the Irish context. The article, part of a larger project to be published in 2003 by Polity Press under the title A Cultural History of Twentieth-Century Irish Literature, is divided into 5 sections: What ish my Nation?; What is a Nation?; Do Nations Have Navels?; 1890s: Winds of Change; English As We Speak It In Ireland. Among Irish authors discussed are Hyde, Shaw. Yeats, Wilde, Lady Gregory, Joyce, and Beckett.

Two Centuries of Literary Competition between Iran and the Subcontinent

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سعید شفیعیون

2010-05-01

Full Text Available Safavid period is one of the most important historical periods of old Iran with regard to foreign relations. Among these, cultural and political relations with India are outstanding due to historical and mostly peaceful backgrounds, especially in the field of Persian language and literature. The influence of Persian literature on India was so much that this country became not only a rich and fruitful place for Iranian poets and literary figures, it also became the origin of another type of Persian literature. Although Iranian poets and literary figures, due to access to innate resources of this language and culture, were considered as the model, the attempts of cultural figures of the Subcontinent had local color and were different from Iranian linguistic and cultural criteria and norms. Because of this, there were a lot of critical controversies over the correctness and eloquence of literary works of Persian speakers of India. Iranians accussed them of doing unfounded innovations and linguistic experiences and these people, instead, claimed that they had the right to do so on the basis of certain reasons.

Nuclear Morphometry in Ductal Breast Carcinoma with Correlation to Cell Proliferative Activity and Prognosis

International Nuclear Information System (INIS)

Radwan, M.M.; Amer, K.A.; Mokhtar, N.M.

2003-01-01

Morphometry is the quantitative description of biologic structures. This study was designed to evaluate the efficiency of morphometric measurements in diagnosis and prognosis of patients with breast carcinoma. Methods: Histological samples from 61 patients of invasive duct carcinoma (IDC) of no special type (NST), 12 cases of ductal carcinoma in situ (DCIS) and 14 control breast samples taken from fibrocystic change disease were retrospectively analyzed by computerized nuclear morphometry. All IDC patients underwent modified radical mastectomy without preoperative chemotherapy. The mean follow up was 28±19 months (range] -71). In each case, 25-50 nuclei were measured and the mean nuclear area (MNA), mean nuclear perimeter (MNP), mean maximum nuclear diameter (MMNO) and mean minimal nuclear diameter (Mmnd) were measured. The mean axis ratio (MAR), mean nuclear compactness (MNC), mean nuclear size (MNS) and mean shape factor (MSHF), were calculated mathematically. To measure the nuclear diameters, a new method was employed using the AutoCAD program. Morphometric parameters were compared with different clinico pathologic features, patient's survival and cell proliferative activity as determined by Ki-67 immunostaining which was evaluated quantitatively. Most of the morphometric parameters were significantly higher in DCIS and IDC groups than benign one. In IDC group morphometric features related to nuclear size (MNA, MNP, MMNO, Mmnd and MNS) were significantly correlated to most clinico pathologic features and cell proliferative activity assessed by Ki-67 immunostaining. However, the shape factor failed to achieve this correlation. The univariate analysis using Kaplan Meier curves indicated that short survival time was correlated with high nuclear morphometric values (MNA. MNP, MMND, Mmnd, MNS and MSHF). Moreover, the Spear man correlation analysis showed that Mmnd has the highest converse correlation with survival (r= -0.75, (ρ < 0.0001). In multivariate analysis

Apoptotic and anti-proliferative effects of all-trans retinoic acid

International Nuclear Information System (INIS)

Zamora, Monica; Ortega, Juan Alberto; Alana, Lide; Vinas, Octavi; Mampel, Teresa

2006-01-01

We examined the apoptotic and anti-proliferative effects of all-trans retinoic acid (atRA) in HeLa cells. Our results demonstrated that HeLa cells were more sensitive to the anti-proliferative effects of atRA than to its apoptotic effects. Furthermore, we demonstrated that caspase inhibition attenuates cell death but does not alter the atRA-dependent reduction in cell proliferation, which suggests that atRA-induced apoptosis is independent of the arrest in cell proliferation. To check whether ANT proteins mediated these atRA effects, we transiently transfected cells with expression vectors encoding for individual ANT (adenine nucleotide translocase 1-3). Our results revealed that ANT1 and ANT3 over-expressing HeLa cells increased their atRA sensitivity. Thus, our results not only demonstrate the different functional activities of ANT isoforms, but also contribute to a better understanding of the properties of atRA as an anti-tumoral agent used in cancer therapy

Atypical proliferative myositis: original MR description with pathologic correlation: Case report

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Jarraya, Mohamed; Guermazi, Ali [Boston University School of Medicine, Department of Radiology, Musculoskeletal Section, Boston, MA (United States); Parva, Pedram [VA Boston Healthcare System, Boston, MA (United States); Stone, Michael [Stamford Hospital, Department of Surgery, Stamford, CT (United States); Klein, Michael J. [Hospital for Special Surgery, Department of Pathology and Laboratory Medicine, New York, NY (United States)

2014-08-15

Proliferative myositis (PM) along with proliferative fasciitis and nodular fasciitis are a group of pseudosarcomatous myofibroblastic proliferations. Although the histologic presentation of each is almost identical, the magnetic resonance imaging (MRI) appearance of proliferative myositis is closer to that of inflammatory myopathies. We report a case of PM in which the imaging and histologic features combine typical findings of PM with unusual imaging features, suggesting of reactive (or nodular) fasciitis. (orig.)

Atypical proliferative myositis: original MR description with pathologic correlation: Case report

International Nuclear Information System (INIS)

Jarraya, Mohamed; Guermazi, Ali; Parva, Pedram; Stone, Michael; Klein, Michael J.

2014-01-01

Proliferative myositis (PM) along with proliferative fasciitis and nodular fasciitis are a group of pseudosarcomatous myofibroblastic proliferations. Although the histologic presentation of each is almost identical, the magnetic resonance imaging (MRI) appearance of proliferative myositis is closer to that of inflammatory myopathies. We report a case of PM in which the imaging and histologic features combine typical findings of PM with unusual imaging features, suggesting of reactive (or nodular) fasciitis. (orig.)

Contribution of Miklošič to the formation of literary Slovenian

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Martina Orožen

1972-12-01

Full Text Available Not enough light has yet been shed on Miklošič's contribution to the formation of the Slovene literary language, nor has his achievement been sufficiently evaluated. His influence on the theoretical basis of the literary norm and on the actual formation of the modern literary language lasted at least half a century (from 1849 to 1916. Miklošič's personality as well as his work ope.ned three important lines of research for Slovene linguistics and for the cultivation of the Slovene language. 1. In his practical work as translator and editor (Obće dedavljanski zakonik; Slovensko berilo Miklosic introduced, in the early fifties, "new forms" into the literary language, and won for them the young generation of students, who established them in journalism and belles lettres. Thereby, the fundamental step, based on synchronic considerations, was taken towards a more uniform grammatical structure of the literary language. (The "new forms" were used in some botder regions within the Slovene speaking area. 2. Miklošič 's scientific research method opened up new research fields not only for Slavic, but also for Slovene studies. Under Miklošič's guidance his students were encouraged to study language history (the Pannonian theory and dialectology, and to describe morphological and syntactic categories of the modern literary language. 3. The application of Miklošič 's historico-comparative linguistic method to the normative description of the modern language (J anežič's grammar of 1863 resulted in an "ideal" etymological/historical orthography for the literary language and contributed to the lasting stability of its morphological system. In some respects this led to considerable recession into the dead past of the language (appeal to Old Church Slavonic and 16th century Slovene. The incorporation into Slovene of Croatian Kajkavian linguistic characteristics as well as the availability of the language features of East Slovenia (Prekmurje, Prlekija

Uric acid stimulates proliferative pathways in vascular smooth muscle cells through the activation of p38 MAPK, p44/42 MAPK and PDGFRβ.

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Kırça, M; Oğuz, N; Çetin, A; Uzuner, F; Yeşilkaya, A

2017-04-01

Hyperuricemia and angiotensin II (Ang II) may have a pathogenetic role in the development of hypertension and atherosclerosis as well as cardiovascular disease (CVD) and its prognosis. The purpose of this study was to investigate whether uric acid can induce proliferative pathways of vascular smooth muscle cell (VSMC) that are thought to be responsible for the development of CVD. The phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK), p44/42 mitogen-activated protein kinase (p44/42 MAPK) and platelet-derived growth factor receptor β (PDGFRβ) was measured by Elisa and Western blot techniques to determine the activation of proliferative pathways in primary cultured VSMCs from rat aorta. Results demonstrated that uric acid can stimulate p38 MAPK, p44/42 MAPK and PDGFRβ phosphorylation in a time- and concentration-dependent manner. Furthermore, treatment of VSMCs with the angiotensin II type I receptor (AT1R) inhibitor losartan suppressed p38 MAPK and p44/42 MAPK induction by uric acid. The stimulatory effect of uric acid on p38 MAPK was higher compared to that of Ang II. The results of this study show for the first time that uric acid-induced PDGFRβ phosphorylation plays a crucial role in the development of CVDs and that elevated uric acid levels could be a potential therapeutical target in CVD patients.

New Transnational Literary Histories on the World Scene

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Remo Ceserani

2013-12-01

Full Text Available Il saggio discute il rapporto sempre più problematico fra storia della letteratura e identità nazionale. Dopo aver esaminato alcune storie recenti che continuano a privilegiare la dimensione nazionale ed esclusivamente letteraria della materia trattata, si sofferma su alcune interessanti esperienze di storie che trattano la produzione culturale e letteraria di intere zone geografiche, a prescindere dalle identità statali, culturali e linguistiche di singoli Paesi e nazioni (per esempio: l’Europa centro-orientale, la penisola iberica, l’intero continente sudamericano. Fra i testi presi in esame: la Storia della letteratura ungherese, a cura di B. Ventavoli (2002-2004, la Storia della letteratura polacca, a cura di L. Marinelli (2004, la Geografia e storia della civiltà letteraria rumena nel contesto europeo, a cura di B. Mazzoni e A. Tarantino (2010, la History of the Literary Cultures of East-Central Europe, a cura di M. Cornis-Pope e J. Neubauer (2004-2010, la New History of German Literature, a cura di D. E. Wellbery e J. Ryan (2004, la New History of French Literature, a cura di D. Hollier (1998, la Comparative History of Literatures in the Iberian Peninsula, a cura di F. Cabo Aseguinolaza, A. Abuín Gonzales e C. Domínguez (2010, la New Literary History of America, a cura di G. Marcus e W. Sollors (2009 e le Literary Cultures of Latin America, a cura di M. Valdés e D. Kadir (2004.

INTERTEXTUALITY AND LITERARY MEMOIRS: READING AS MEMOIRS’ PRAXIS IN RUI KNOPFLI

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Otavio Henrique Meloni

2013-11-01

Full Text Available Reading and writing practices are inseparable, quite intimate and revealing a deep memory exercise. For most people it is such an exercise, and always shares the memory associated intimate fragments with social and cultural aspects. So when we think of memory that is built through the readings of an individual, we have various spheres of thought and reflection on the same reality, even transformed by his gaze reader. This paper discusses the role of literary memoirs in building the poetic universe of Mozambican Rui Knopfli, taking into account their condition “deterritorialized” and the  need to assert a place of belonging (reading as bound reference. This site security is strengthened at the junction memory literary with intertextu­ality that it causes. We thus believe that the literary memoirs assume the role of place belongs to the poetical subject of Mozambique, softening their fractures of naturalness, stating and justifying the existence of the subject through their reading experience.

Proliferative and morphologic changes in rat colon following bypass surgery.

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Barkla, D H; Tutton, P J

1985-06-01

In this study the proliferative and morphologic changes that occur in the colon of normal and dimethylhydrazine-treated rats following surgical bypass of the middle third of the colon are reported. Proliferative changes were measured by estimating accumulated mitotic indexes following vinblastine treatment and morphologic changes were observed with the use of light microscopy and scanning electron microscopy. Data were collected on Days 0, 7, 14, 30, and 72 after surgery. The results show that surgical bypass produces contrasting effects in the segments proximal to and distal to the suture line. In the proximal segment there was morphologic evidence of hyperplasia, although proliferative activity was unchanged except for an increase at 7 days in normal rats. In the distal segment there was a long-lived increase in the mitotic index, although morphologic changes were not seen. The results for DMH-treated rats were similar to those in normal rats. Groups of isolated dysplastic epithelial cells were often seen in the submucosa adjacent to sutures up to 72 days after surgery. Increased lymphoid infiltration was seen in segments proximal to but not distal to the suture line. It is hypothesized that the different responses of the proximal and distal segments may be related to the different embryologic origins of those segments. It is also hypothesized that the seeding of the submucosa with epithelial cells during suturing may be a factor in tumor recurrence.

Proliferative changes in nonpalpable breast lesions detected by mammography

International Nuclear Information System (INIS)

Vega, A.; Delgado, A.; Ortega, E.; Garijo, F.; Mosquera, J.; Sogo, C.; Alvarez, A.

2000-01-01

To analyze retrospectively the radiological findings in nonpalpable breast lesions detected by mammography that lead to the performance of surgical biopsy, resulting in a histological diagnosis of proliferative breast disease with and without atypia. From two Spanish hospitals, 421 women with 429 biopsies indicative of the presence of proliferative breast disease with and without atypia were selected out of a total of 1252 surgical biopsies in nonpalpable lesions that proved to be benign. Age, personal and familial history of breast cancer, reason for requesting the mammography and radiological findings that had indicated the need for surgical biopsy were recorded for each patient. The diagnosis was proliferative breast disease (epithelial hyperplasia) in 347 women with 354 biopsies and atypical hyperplasia in the remaining 74 women with 75 biopsies, representing 28% and 6%, respectively, of the 1252 biopsies of lesions found to be benign. In 221 of the 354 cases of epithelial hyperplasia (62%) and 45 of the 75 cases of atypical hyperplasia (60%), the presence of calcifications was the most common radiological findings leading to biopsy (p<0.05). Parenchymal distortion, with or without calcifications, was the second most common radiological sign. The histological study revealed a close relationship between these proliferative events and radial scars. Calcifications are the radiological finding that most frequently indicate the need for surgical biopsy in nonpalpable lesions that results in a diagnosis of proliferative breast disease with and without atypia. (Author) 12 refs

I read. You read? Challenges and possibilities in working with literary literacy

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Sayonara Abrantes de Oliveira

2017-07-01

Full Text Available This article is the result of a project linked to the Institutional Program of Scientific Initiation Scholarships for Higher Education (PIBIC-EM. The program’s objective was to analyze the contributing factors for the process of reading literacy training in order to verify how young people make their choices of literary texts, as well as know the difficulties and facilities they face in contact with these genres. To do so, we used the quantitative qualitative research through the application of a questionnaire, consisting of open questions, and applied to the students of the Integrated in Information Technology and Integrated Technician in the Environment of the Federal Institute of Education, Science and Technology of Paraíba (IFPB/campus Sousa courses. We also analyzed the perceptions derived from the observations of the Reader Club of the same campus, in an attempt to verify how the intervention of activities that mediate literary literacy favors the stimulus to the reading formation. Based on the data analysis, we observed that the student's distance element from reading is the lack of incentive, that is, the construction of an atmosphere that surrounds him, both in the classroom and in the other environments that welcome him. To overcome this, it is necessary for the teacher to have a theoretical-methodological apparatus guiding in his classes, since mediation favors literary literacy, having as support the Receptional Method and a conception of reading that articulates the interactional to the discursive, helping in the organization and selection of texts, in order to achieve the objectives of the formation of the reader.

"Je n'aimais pas ce public..." Une pratique active du texte litteraire ("I Didn't Like This Public..." An Active Exercise with the Literary Text).

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Dell'Utri, Salvatore

1990-01-01

A series of French language classroom exercises to be used over four class sessions applies principles of semiotics to literary textual analysis. The session themes include decoding and interpreting, reconstructing meaning, sociocultural connotations in the text, and sense of time and space. (MSE)

Critical Thinking Skills to Literary Works: A Method of Teaching Language through Literature

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Fithriyah Inda Nur Abida

2016-05-01

Full Text Available Teaching a language has become a challenging task for the teachers to train and to teach language for their students. In present time, the ability to master a language is vital for a language is a powerful means of  communicating. Most of us will not focus on the language present in the literature part because our mind sets only towards the grammar. This has made both the teacher and students to ignore the literature part and made them to focus only on grammatical part to learn language. The urge behind using literary works in the teaching a language is to argue that the current attempts to implant literary works to the teaching of a language definitely develop students’ critical thinking in such a way that help them to easily master a particular language. Learning literary works in a classroom not only make the students learn about a story but also study how the language are structured and how its structured bring a great difference in meaning. Through a literary works student sees the language of real-life contexts. They learn the feelings, ideas, and experiences of linguistics components that give a realistic touch and help them to learn a language in a comprehensive way. It is also found that using literary works in the teaching learning process can improve student’s ability both in micro-linguistics and macro-linguistics.

Some considerations about literary analysis modern methods from a didactic perspective

OpenAIRE

Marialina Ana García Escobio; Moraima Pérez Barrera; María del Carmen Miló Anillo

2016-01-01

This article make it possible a close look to the modern methods of literary analysis, taking as the starting point what the teaching of literature in the joyful context should fulfill in the study of the literary play and the processes of reception and aesthetic statement, as well as the application of the aforementioned methods in the attempt to make the student arrive at rational position; But, at the same time, he/she should feel creator and coauthor of an event that should be lived from ...

Extraction, purification and anti-proliferative activities of polysaccharides from Lentinus edodes.

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Zhao, Yong-Ming; Wang, Jin; Wu, Zhi-Gang; Yang, Jian-Ming; Li, Wei; Shen, Li-Xia

2016-12-01

In this study, the enzyme-assisted extraction of polysaccharides from Lentinus edodes (LEPs) was optimized by response surface methodology, and a preliminary characterization of the extracted LEPs and their anti-proliferative activities were investigated. An orthogonal assay was constructed to determine the optimal amounts of cellulase, papain and pectinase, which were 15, 20 and 15g/kg, respectively. Then effects of extraction conditions were evaluated and optimized using a Box-Behnken design. The results showed that the highest polysaccharides yield of 15.65% was achieved with an extraction temperature of 54°C, pH 5.0, enzymatic treatment time of 93min and a liquid/material ratio of 29:1mL/g, which correlated well with the predicted yield of 15.58%. Subsequently, the crude LEPs were further purified by DEAE-cellulose and Sephadex-100 chromatography to obtain two fractions, which were designated as LEP-1 and LEP-2 and their monosaccharide compositions were characterized by GC. Fourier-transform infrared spectra demonstrated that LEP-1 and LEP-2 were distinct from each other regarding their chemical structures. In addition, the LEPs exhibited inhibition of cell proliferation on HCT-116 and HeLa cells in vitro. In summary, this study provides an efficient enzyme-assisted extraction for LEPs, which can be used as natural antitumor agents in the pharmaceutical and functional food industries. Copyright © 2016 Elsevier B.V. All rights reserved.

Exploring the Materiality of Literary Apps for Children

DEFF Research Database (Denmark)

Henkel, Ayoe Qvist

2016-01-01

Children’s literature is increasingly being realized in app format, with its possibilities of combining text, music, sound effects, stills, animated movies, verbal language, and, not least, interactivity. This digital and medial literary development calls for new analytical approaches to explore...

CONTEXTUAL APPROACH TO LITERARY CRITICISM: DOSTOEVSKY AND PSYCHOANALYSIS

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V. G. Kalashnikov

2016-01-01

Full Text Available The aim of this article is to demonstrate the possibilities of application of the contextual approach, developed in pedagogy and psychology, in the process of literary analysis. Initially contextual approach was developed by A. A. Verbitsky as a methodology of education. A key category of this approach was the context, interpreted A. A. Verbitsky as a psychological phenomenon. Accordingly, in this paper on the basis of later research context is understood as a psychological mechanism of semantic, objectified in external forms of test patches, social and communicative situations, etc. Now contextual approach became general psychological methodology, which led to the possibility of its application in various fields of the humanities in particular – in psycholinguistic literary studies, where the notion of «context » is used in-depth psychological interpretation. Methods. The contextual approach developed by A. A. Verbitsky as the main component of methodology of education became the main instrument of the research stated in the publication. Besides a field of the general education, this approach is applicable to various private spheres – to educational aspect of education, and also to methodology of teaching various subject matters – mathematicians, biology, foreign languages, etc. The contextual approach at the level of allpsychological methodology has allowed to apply it in various fields of humanitarian knowledge, in particular in literary researches with a strongly pronounced psychological perspective. The contextual analysis corresponding to approach has been chosen as a method of work.Results. Based on A. A. Verbitsky’s interpretation and results of the latest researches the author shows that the context is a semantic mechanism, objectified in external forms of test fragments, social and communicative situations, etc. The following types of contexts are allocated: microcontext of a personality and works of an author, a mesocontext

LITERARY THEMES IN ITALIAN PERIODICALS IN RIJEKA FROM 1900 TO 1919

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Dolores Miškulin

2013-01-01

Full Text Available Despite the abundance of periodicals in Italian language in Rijeka in the second half of the 19th century and early 20th century, their comprehensive and systematic research together with their modern and objective evaluation is still insufficient. With the aim of contributing to the elucidation and analysis of under-studied Italian publications in Rijeka, we have tried to consider from the contemporary point of view the context in which the subject of our interest appears, to study the available written documents, and to evaluate the facts of literary phenomena within a given corpus. We have tried to substantiate by examples the thesis that literary themes in our local newspapers and magazines of Italian language expression, besides further exploring the Italian literary heritage, have contributed to our overall cultural events through the opening of aesthetic horizons of readers and a number of authors, and have largely contributed to the intertwining of the two cultures. Through testing, systematization and classification of literary topics, we concluded that newspapers and magazines in Rijeka, as the most important medium of the historical period that we examined, have had a significant and dynamic part in the process that led to the gradual change of mindset, views on society and art, and an overall way of thinking and action. In our opinion, through our contribution we have tried to reconstruct from oblivion a valuable segment of Rijeka's cultural heritage.

Semiotics of Umberto Eco in a Literary Translation Class: The Model Reader as the Competent Translator

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Ozturk Kasar, Sündüz; Can, Alize

2017-01-01

Classroom environment can be thought as an absolute place to practice and improve translation skills of students. They have the possibility to brainstorm and discuss problematic points they face with each other during a translation activity. It can be estimated in the same way in a literary translation class. Students who are supposed to become…

The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes

International Nuclear Information System (INIS)

Thomas, Maria; Bayha, Christine; Klein, Kathrin; Müller, Simon; Weiss, Thomas S.; Schwab, Matthias; Zanger, Ulrich M.

2015-01-01

The peroxisome proliferator-activated receptor alpha (PPARα) controls lipid/energy homeostasis and inflammatory responses. The truncated splice variant PPARα-tr was suggested to exert a dominant negative function despite being unable to bind consensus PPARα DNA response elements. The distribution and variability factor of each PPARα variant were assessed in the well-characterized cohort of human liver samples (N = 150) on the mRNA and protein levels. Specific siRNA-mediated downregulation of each transcript as well as specific overexpression with subsequent qRT-PCR analysis of downstream genes was used for investigation of specific functional roles of PPARα-wt and PPARα-tr forms in primary human hepatocytes. Bioinformatic analyses of genome-wide liver expression profiling data suggested a possible role of PPARα-tr in downregulating proliferative and pro-inflammatory genes. Specific gene silencing of both forms in primary human hepatocytes showed that induction of metabolic PPARα-target genes by agonist WY14,643 was prevented by PPARα-wt knock-down but neither prevented nor augmented by PPARα-tr knock-down. WY14,643 treatment did not induce proliferative genes including MYC, CDK1, and PCNA, and knock-down of PPARα-wt had no effect, while PPARα-tr knock-down caused up to 3-fold induction of these genes. Similarly, induction of pro-inflammatory genes IL1B, PTGS2, and CCL2 by IL-6 was augmented by knock-down of PPARα-tr but not of PPARα-wt. In contrast to human proliferative genes, orthologous mouse genes were readily inducible by WY14,643 in PPARα-tr non-expressing AML12 mouse hepatocytes. Induction was augmented by overexpression of PPARα-wt and attenuated by overexpression of PPARα-tr. Pro-inflammatory genes including IL-1β, CCL2 and TNFα were induced by WY14,643 in mouse and human cells and both PPARα forms attenuated induction. As potential mechanism of PPARα-tr inhibitory action we suggest crosstalk with WNT/β-catenin pathway. Finally

A Review on Developing Critical Thinking Skills through Literary Texts

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Noraini Ahmad Shukri

2015-04-01

Full Text Available Many ESL instructors are generally in agreement with the belief that it is essential that students should be assisted in developing critical thinking skills while being engaged in their language learning process especially those learning the target language at higher level (Stern, 1985; Dickinson, 1991; McKay, 2001; Terry, 2007; Van, 2009; Odenwald, 2010. As it enables language learners to engage in a more purposeful and self-regulatory in judgment, helping them in their evaluation of the arguments of others and of their own, coming to well-reasoned resolutions to any complex problems and to be able to resolve conflicts encountered in their daily lives. Critical thinking requires them to be actively involved in their own learning process as they attempt to individually understand and apply the information they are exposed to during the classroom interaction (Landsberger, 1999; Tung & Chang, 2009. The many advantageous and feasibility of teaching instruction that incorporates the study of literature in the ESL classroom which suggests that literature texts, if correctly chosen and instructed, can prove to be beneficial to ESL students’ overall level of literacy and critical thinking skills. Numerous empirical researches also asserted that literary texts that are authentic, enjoyable, and motivating would naturally increase both their knowledge of the target language patterns and cultural awareness. Keywords: Critical thinking, ESL classroom, literature, literary text

Modifying the explanation of Anvari Abivardi’s literary theory

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Fatemeh Hakima

2016-02-01

Full Text Available Abstract   In the first place, the literary theory is about finding an answer to the question on what makes a verbal message into a work of art . This is related to the particular distinction of Lingual arts from other arts, and other types of Lingual behaviors . That is why literary theory is in the first position among literary studies. (Ahmadi, 1996: 1st volume/77 One of the fundamental aspects of literary studies is interpreting ancient texts from the perspective of the poet or writer’s own literary theory . On this basis, this article aims to discuss the literary theory and poetry structure of Anvari . Indisputably, Anvari’s structure is special and it is certainly based on the perspective, insight and cultural and social conditions in which it grew and formed. Each poet is the composer of their poetry and oratory and Anvary, himself, is the most informed person about his elocution method. He mentioned the elocution method in several places in his Divan:   However, you looking into poetry styles   All taken into account the best style is mine (Anvari, 1958: 1st volume/85   Accordingly, his Divan has been subjected to scrutiny, and judgment criteria have been derived from the verses of the poet .   Anvari believed that poetry is the result of integrating content with discourse whose output is captured hearts . He called poets the granters of speech and in composing poetry, he believed content is prior to discourse. He has an opinion that the container of discourse does accommodate content that on this basis he approached the ideas of " modern hermeneutics ”. He praised original meaning- which was not adopted by other poems- and he described proper poetry using graceful and delicate characteristic. In fact, in his viewpoint, a poem which has original meaning and graceful and delicate verse is a literary discourse which influences the reader .  From his viewpoint:  1- Improvisation and spontaneity   2- Composing in any literary

Amniocar as a proliferative medium for mesenchymal cells

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V. V. Chestkov

2014-01-01

Full Text Available Objectives. To develop the Amniocar nutrient medium that contains fetal calf serum (FCS and growth factors cocktail for mass cultivation of human fibroblasts. To study proliferative activity of the medium on cultures of HUVEC cells of mesenchymal origin and mesenchymal stromal cells, as well as on cell culture of human amniotic fluid.Materials and methods. Determination of the rate of accumulation of the cellular mass and cell morphology in the course of cultivation of cells of various histogenesis in the Amniocar medium and nutrient medium that contains 10 % of FCS.Results. It has been demonstrated that the Amniocar medium is prevalent as compared to the standard DMEM medium with 10 % of FCS by 2 to 5 times for cultivation of skin fibroblasts, HUVEC, and mesenchymal stem cells. The Amniocar medium increased the quantity of endothelial cells that enter mitosis and maintained the culture of HUVEC cells with prolonged passaging in vitro. Clonal cultivation of human amniotic fluid cells in the Amniocar medium secured development of colonies of both fibroblast and epithelial type.Conclusions. Proliferative Amniocar medium is efficient for mass cultivation of various cells of mesenchymal origin and can be used for diagnostic purposes in medical genetics, oncology, etc.

ON FEMALE LITERARY FIGURATIONS IN KAMOV’S TRAVESTY ŽENA (WOMAN

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Brigita Miloš

2014-01-01

Full Text Available The aim of this paper is to point out the perceived particularity of individual literary figurations as thresholds of subversion of the ‘economy of the same’. The suggested reading considers various materialities of the text that can refer to the modes of performative structures, as well as to the interpretations of female gender identity positions. When the ‘essence’ of femininity is questionable and the status of gender related ideals relative, then different possibilities of gender performatives are those that generate gender imagery of this Kamov’s literary text.

Correlation of proliferative and clonogenic tumor cells in multiple myeloma

International Nuclear Information System (INIS)

Karp, J.E.; Burke, P.J.; Saylor, P.L.; Humphrey, R.L.

1984-01-01

To expand on the findings from previous clinical trials that the growth of residual tumor is increased at a predictable time following initial drug administration, malignant plasma cells from bone marrows of patients with multiple myeloma (MM) were examined for changes in proliferation and clonogenicity induced in vivo by cyclophosphamide and in vitro by drug-induced humoral stimulatory activity. Peak plasma cell [ 3 H]thymidine labeling index (LI) occurred predictably following drug and paralleled changes in agar colony formation by marrow cells obtained during therapy. Colony-forming capacity of pretreatment MM marrow populations was enhanced when those cells were cultured with humoral stimulatory activity, similar to the increased colony formation detected in Day 9 postcyclophosphamide marrows at the time of peak plasma cell LI. To further define a relationship between proliferative plasma cells and colony-forming tumor cells, MM marrows were fractionated by sedimentation on an isokinetic gradient. Enrichment of a proliferative tumor cell cohort was achieved, evidenced by [ 3 H]thymidine LI. Colony-forming cells were also enriched by isokinetic gradient sedimentation, and agar colony formation by MM marrow cell fractions correlated with the kinetic characteristics of the isolated subpopulations. These studies of whole and fractionated human MM marrow cell populations suggest that the kinetically active cells which are induced to proliferate in vivo and in vitro are closely related to the clonogenic tumor cells which produce colonies in agar and which, like those cells measured by [ 3 H]thymidine LI, respond to growth stimulation by drug-induced humoral stimulatory activity

Ecological economics and literary communication: Axes of discourse ...

African Journals Online (AJOL)

Ecological economics and literary communication: Axes of discourse in Ifeanyi Izuka's Travails of the black gold. ... and environmental messages that affect the econiche, and for exploring human conditions and values as characters react to extraordinary economic and ecological situations that have universal application.

Inhibition of proliferative activity in tissue culture in vivo of esophagus and stomach tumour cells under preoperative irradiation

International Nuclear Information System (INIS)

Zinchenko, V.A.; Okulov, L.V.; Gol'dshmid, B.Ya.

1988-01-01

Inhibition of proliferative activity of tumor cells as a result of radiation effect. Tumor tissue taken from patiets with preoperative tumor irradiation by 30 Gy cumulative dose (5 Gy per a session) and from patients whose tumors were not subjected to irradiation (control) was used. The tumor tissue was cultivated in the diffusion chamber and then implanted to the abdominal cavity of the non-inbred male rats. On preparations in the growth area pathomorphological changes were evaluated, the share of mitotically dividing and DNA-synthesizing cells was determined. The absence of growth area around the explant, obvious reduction of mitotic activity and DNA-synthesizing function of cells in preparations of irradiated tumors in 88 % of cases testify to the inhibition of the stomach cardial section and esophagus tumor tissue repopulation after radiation effect. The investigation results confirm the advisability of preoperative irradiation of patients with tumors of the given localization

Cognitive literary Anthropology and Neurohermeneutics. A theoretical Proposal

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Federica Claudia Abramo

2017-06-01

Full Text Available Following Wolfgang Iser’s studies, literary criticism could no longer avoid a confrontation with the phenomenology of the act of reading. This has led the analysis of a literary text towards new researches regarding the reader’s response theory. In particular, it is impossible to define the field of literary investigation, its coordinates and characteristics, without considering the anthropological dimention which defines the epistemological nature of literature itself. We propose in this study a new approach that we call “neurohermeneutic approach”. Unlike an analytical or descriptive approach, the neurohermeneutic approach investigates broth the relations that the reader’s mind establishes with the text figurations and how these figurations stimulates the reader’s mind in that inexhaustible, always new and surprising act of the reading.   A partire dagli studi di Wolfgang Iser, la riflessione critica non ha più potuto evitare il confronto con la fenomenologia dell’atto della lettura, e questo ha condotto l’analisi del testo fino alle recenti ricerche in merito alla reader’s response theory. Soprattutto risulta ormai impossibile definire il campo di indagine letterario, le sue caratteristiche e coordinate, a prescindere da un affondo nella dimensione antropologica che definisce la natura epistemologica della letteratura stessa. Proponiamo in questo studio un nuovo approccio che definiamo “neuroermeneutico” e che, a differenza di un approccio analitico o descrittivo, indaga sia le relazioni che la mente del lettore instaura con le figurazioni del testo, sia come queste figurazioni sollecitino la mente del lettore in quell’atto inesauribile, sempre nuovo e sorprendente, della lettura.

The Relationship between Home Literary Environments and Attitudes toward Reading in Ninth-Grade Students.

Science.gov (United States)

Kubis, Mary Ellen

A study determined what variables in the home literary environments of ninth-grade students influenced their attitudes toward reading. Subjects, 316 students from 2 ninth-grade classes at 2 metropolitan high schools, were given the Estes Reading Attitude Scale and a researcher-developed, 30-question inventory of their home literary environment.…

Literary Genres in Social Life: A Narrative, Audio-visual and Poetic Approach

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Luis Felipe González Gutiérrez

2008-05-01

Full Text Available The proposal, "Literary Genres in Social Life: a Narrative, Audio-visual and Poetic Approach", attempts, by objective, to present/display to the academic psychology community and compatible social science disciplines the main contributions of literary genre theory through a social constructionist understanding of narrations and daily stories, and by means of an interactive construction of narrative collage. This work, sustained by an investigation financed by the University Santo Tomás in Bogota, Colombia, "Understanding of structuralist literary theories in the development of the narrative 'I' within the social constructionist approach", tries to propose alternative spaces for the presentation of its investigative results through the expression of metaphors, visual narrative sequences and interactive artistic forms, which invite the spectator to share in and to include/understand important concepts in the consolidation of social forms of construction of the quotidian. URN: urn:nbn:de:0114-fqs0802373

Bilateral proliferative retinopathy in B-cell acute lymphoblastic leukemia

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Devesh Kumawat

2018-01-01

Full Text Available A 4-year-old child with B-cell acute lymphoblastic leukemia presented with vitreous hemorrhage due to proliferative retinopathy in both eyes. Pars plana vitrectomy was performed in both eyes to clear nonresolving vitreous hemorrhage after systemic stabilization. Visual recovery was limited by the disc drag in the right eye and subfoveal exudation in the left eye. Etiopathogenesis and management of proliferative retinopathy in acute leukemias are discussed.

RETRACTED: Translating Connotative Meaning in Literary Texts at the University of Petra

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Akram M. Beiruti

2013-09-01

Full Text Available This article is primarily concerned with the investigation of the importance of connotation in translation. The four meanings normally discussed in semantics are denotation, connotation, reference and sense. Denotation is the frame of meaning, which is found in definitions given by dictionaries; while connotation is an additional shade of meaning added to the denotation of a word. Pragmatic meanings play an important role in the interpretation of a literary text. They need to be handled carefully by translators, and are likely not to survive the process of translation. Their meanings are fragile and often culture specific. They may also be highly personal associated with the author himself. In literary translation, meaning can only be accurate to a certain degree, since it is looking for the connotative as well as the denotative meanings. As such the successful translator is aware of the multiple meanings of the word. Whilst the translator has to cope with the different shades of word meanings, which are in non-literary translation, he can achieve anywhere near perfection. It worth mentioning that poetry is the hardest of all literary genres to translate, because it has some linguistic factors to account for (notably sound, rhyme and meter and connotation. Thus the importance of connotation is of utmost importance in translation. which translators have to be aware of.

The Literary Language of Cervantes El comedido hidalgo by Eslava Galán

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Juan Miguel Monterrubio Prieto

2016-11-01

Full Text Available The aim of this work is to study in what way Eslava incorporates into “El Comedido Hidalgo” the literary techniques of Cervantes. It has been pointed out that Cervantes created, in some passages, an archaic language with a medieval appearance. Eslava, on the other hand, makes up a new language; new because it is not an accurate reproduction of the XVI and XVII centuries spoken language. This work shows how the novel fits a great amount of literary resources of Cervantes but in a different and new way. It is not about an exact copy of Cervantes´s literary techniques, but a hyperbole, sometimes transgressive, of these techniques. It is also a support of a critical, ironical and burlesque view of the Spanish Golden Era.

Using "The Giving Tree" To Teach Literary Criticism.

Science.gov (United States)

Remler, Nancy Lawson

2000-01-01

Argues that introducing students to literary criticism while introducing them to literature boosts their confidence and abilities to analyze literature, and increases their interest in discussing it. Describes how the author, in her college-level introductory literature course, used Shel Silverstein's "The Giving Tree" (a children's…

Antimicrobial and Anti-Proliferative Effects of Skin Mucus Derived from Dasyatis pastinaca (Linnaeus, 1758

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Virginia Fuochi

2017-11-01

Full Text Available Resistance to chemotherapy occurs in various diseases (i.e., cancer and infection, and for this reason, both are very difficult to treat. Therefore, novel antimicrobial and chemotherapic drugs are needed for effective antibiotic therapy. The aim of the present study was to assess the antimicrobial and anti-proliferative effects of skin mucus derived from Dasyatis pastinaca (Linnaeus, 1758. Our results showed that skin mucus exhibited a significant and specific antibacterial activity against Gram-negative bacteria but not against Gram-positive bacteria. Furthermore, we also observed a significant antifungal activity against some strains of Candida spp. Concerning anti-proliferative activity, we showed that fish mucus was specifically toxic for acute leukemia cells (HL60 with an inhibition of proliferation in a dose dependent manner (about 52% at 1000 μg/mL of fish skin mucous, FSM. Moreover, we did not observe effects in healthy cells, in neuroblastoma cells (SH-SY5Y, and multiple myeloma cell lines (MM1, U266. Finally, it exhibited strong expression and activity of chitinase which may be responsible, at least in part, for the aforementioned results.

Prolonged effect of fluid flow stress on the proliferative activity of mesothelial cells after abrupt discontinuation of fluid streaming

International Nuclear Information System (INIS)

Aoki, Shigehisa; Ikeda, Satoshi; Takezawa, Toshiaki; Kishi, Tomoya; Makino, Junichi; Uchihashi, Kazuyoshi; Matsunobu, Aki; Noguchi, Mitsuru; Sugihara, Hajime; Toda, Shuji

2011-01-01

Highlights: ► Late-onset peritoneal fibrosis leading to EPS remains to be elucidated. ► Fluid streaming is a potent factor for peritoneal fibrosis in PD. ► We focused on the prolonged effect of fluid streaming on mesothelial cell kinetics. ► A history of fluid streaming exposure promoted mesothelial proliferative activity. ► We have thus identified a potent new factor for late-onset peritoneal fibrosis. -- Abstract: Encapsulating peritoneal sclerosis (EPS) often develops after transfer to hemodialysis and transplantation. Both termination of peritoneal dialysis (PD) and transplantation-related factors are risks implicated in post-PD development of EPS, but the precise mechanism of this late-onset peritoneal fibrosis remains to be elucidated. We previously demonstrated that fluid flow stress induced mesothelial proliferation and epithelial–mesenchymal transition via mitogen-activated protein kinase (MAPK) signaling. Therefore, we speculated that the prolonged bioactive effect of fluid flow stress may affect mesothelial cell kinetics after cessation of fluid streaming. To investigate how long mesothelial cells stay under the bioactive effect brought on by fluid flow stress after removal of the stress, we initially cultured mesothelial cells under fluid flow stress and then cultured the cells under static conditions. Mesothelial cells exposed to fluid flow stress for a certain time showed significantly high proliferative activity compared with static conditions after stoppage of fluid streaming. The expression levels of protein phosphatase 2A, which dephosphorylates MAPK, in mesothelial cells changed with time and showed a biphasic pattern that was dependent on the duration of exposure to fluid flow stress. There were no differences in the fluid flow stress-related bioactive effects on mesothelial cells once a certain time had passed. The present findings show that fluid flow stress exerts a prolonged bioactive effect on mesothelial cells after termination

Heme oxygenase is not involved in the anti-proliferative effects of statins on pancreatic cancer cells

International Nuclear Information System (INIS)

Vanova, K.; Boukalova, S.; Gbelcova, H.; Muchova, L.; Neuzil, J.; Gurlich, R.; Ruml, T.; Vitek, L.

2016-01-01

Pancreatic cancer is recognized as one of the most fatal tumors due to its aggressiveness and resistance to therapy. Statins were previously shown to inhibit the proliferation of cancer cells via various signaling pathways. In healthy tissues, statins activate the heme oxygenase pathway, nevertheless the role of heme oxygenase in pancreatic cancer is still controversial. The aim of this study was to evaluate, whether anti-proliferative effects of statins in pancreatic cancer cells are mediated via the heme oxygenase pathway. In vitro effects of various statins and hemin, a heme oxygenase inducer, on cell proliferation were evaluated in PA-TU-8902, MiaPaCa-2 and BxPC-3 human pancreatic cancer cell lines. The effect of statins on heme oxygenase activity was assessed and heme oxygenase-silenced cells were used for pancreatic cancer cell proliferation studies. Cell death rate and reactive oxygen species production were measured in PA-TU-8902 cells, followed by evaluation of the effect of cerivastatin on GFP-K-Ras trafficking and expression of markers of invasiveness, osteopontin (SPP1) and SOX2. While simvastatin and cerivastatin displayed major anti-proliferative properties in all cell lines tested, pravastatin did not affect the cell growth at all. Strong anti-proliferative effect was observed also for hemin. Co-treatment of cerivastatin and hemin increased anti-proliferative potential of these agents, via increased production of reactive oxygen species and cell death compared to individual treatment. Heme oxygenase silencing did not prevent pancreatic cancer cells from the tumor-suppressive effect of cerivastatin or hemin. Cerivastatin, but not pravastatin, protected Ras protein from trafficking to the cell membrane and significantly reduced expressions of SPP1 (p < 0.05) and SOX2 (p < 0.01). Anti-proliferative effects of statins and hemin on human pancreatic cancer cell lines do not seem to be related to the heme oxygenase pathway. While hemin triggers reactive

The teacher's role in selecting a methodological approach to the interpretation of a literary work

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Stakić Mirjana M.

2016-01-01

Full Text Available The paper looks at the teacher's role in selecting a methodological approach to the interpretation of a literary work. The choice of methodological approach is dependent on: 1 the semiotic structure of the literary text; 2 the specific educational goals of interpretation; 3 the students' age, psychophysical abilities and knowledge, and 4 the planned circumstances of instruction. In selecting a method of interpretation, the teacher should take into consideration not only these factors, but also contemporary literary theory and its methodological apparatus. This can be a challenging task whose fulfillment does not guarantee that the interpretation will be successful, since the validity and functionality of the methodological approach cannot be established in theory but rather through teaching practice. It is up to the teacher to be creative, because a literary work cannot be interpreted by means of a single method but always through a combination of methods, certain of which have their origins in literary theory. There is a widespread belief among teachers that these methods, which have the status of technical/special methods in literary methodology, cannot be used in the first four grades of elementary school. This paper offers an example illustrating that the interpretive model can be used as early as first grade. A teacher's knowledge, as well as their creativity in selecting a method and their openness to creative methodological combinations and skill in applying them, directly affect the effectiveness of interpretation, either succeeding in developing a fondness for books and reading, or, failing that, resulting in a permanent loss of interest in the world of literature.

Tragedy and the sovereignty of God: Christian literary criticism and the concept of tragedy

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I. Haarhoff

1979-03-01

Full Text Available A Christian approach to literature is easily confused with a theological approach. There are many dangers implicit in such an approach. Sallie McFague TeSelle says the following about theologians who presume to violate the bounds of both theology and literature by attempting literary criticism: “There is no reason to suppose that those trained in theology, or philosophy for that matter, are likely to possess, what is essential to the practice of literary criticism, that ‘sensitiveness of the intelligence’ described by Matthew Arnold as equivalent to conscience in moral matters. A theological training seems to have a disabling effect and has subsequently to be struggled against when literary criticism is the concern.” (TeSelle 1966:4.

Violent Children in Today's Schools: A Literary Review and a Behavior Management Plan for Administrators.

Science.gov (United States)

Moore, Paula; Karr-Kidwell, PJ

This paper presents a relevant literary review and then develops a behavior-management program within schools encompassing social-skills training for all children. Both the literary review and this program can be used to educate administrators, educators, parents, and students about behaviors and warning signs associated with violent children. The…

Edward Said's Worldliness, Amateurism and Heterotopia: Negotiating the Interdisciplinarity of Literary Theory, Canonicity, and Paradigm

Science.gov (United States)

Abu-Shomar, Ayman

2016-01-01

Literary criticism nowadays is essentially crossing the boundaries of disciplinarity and canonicity where literary theory has increasingly been shaped by overlapping concepts and branching out of theories as well as whipping out the limitations imposed by theory itself. The post-conditions of contemporaneity have imposed a view of reading and…

Classification and Criticism of Nigeria Literary Drama | Iwuchukwu ...

African Journals Online (AJOL)

Nigerian drama has gained prominent and permanent position on the world literary map especially with the winning of the Nobel Prize by Wole Soyinka. In spite of this, problems of definition and criticism of Nigerian drama still persists. The Relativist-Evolution controversies on the origin and classification of Nigerian drama ...

Proliferative effects of apical, but not basal, matrix metalloproteinase-7 activity in polarized MDCK cells

International Nuclear Information System (INIS)

Harrell, Permila C.; McCawley, Lisa J.; Fingleton, Barbara; McIntyre, J. Oliver; Matrisian, Lynn M.

2005-01-01

Matrix metalloproteinase-7 (MMP-7) is primarily expressed in glandular epithelium. Therefore, its mechanism of action may be influenced by its regulated vectorial release to either the apical and/or basolateral compartments, where it would act on its various substrates. To gain a better understanding of where MMP-7 is released in polarized epithelium, we have analyzed its pattern of secretion in polarized MDCK cells expressing stably transfected human MMP-7 (MDCK-MMP-7), and HCA-7 and Caco2 human colon cancer cell lines. In all cell lines, latent MMP-7 was secreted to both cellular compartments, but was 1.5- to 3-fold more abundant in the basolateral compartment as compared to the apical. However, studies in the MDCK system demonstrated that MMP-7 activity was 2-fold greater in the apical compartment of MDCK-MMP-7 HIGH -polarized monolayers, which suggests the apical co-release of an MMP-7 activator. In functional assays, MMP-7 over-expression increased cell saturation density as a result of increased cell proliferation with no effect on apoptosis. Apical MMP-7 activity was shown to be responsible for the proliferative effect, which occurred, as demonstrated by media transfer experiments, through cleavage of an apical substrate and not through the generation of a soluble factor. Taken together, our findings demonstrate the importance of MMP-7 secretion in relation to its mechanism of action when expressed in a polarized epithelium

Anti-proliferative and mutagenic activities of aqueous and methanol extracts of leaves from Pereskia bleo (Kunth) DC (Cactaceae).

Science.gov (United States)

Er, Hui Meng; Cheng, En-Hsiang; Radhakrishnan, Ammu Kutty

2007-09-25

The anti-proliferative effects of the aqueous and methanol extracts of leaves of Pereskia bleo (Kunth) DC (Cactaceae) against a mouse mammary cancer cell line (4T1) and a normal mouse fibroblast cell line (NIH/3T3) were evaluated under an optimal (in culture medium containing 10% foetal bovine serum (FBS)) and a sub-optimal (in culture medium containing 0.5% FBS) conditions. Under the optimal condition, the aqueous extract showed a significant (pCactaceae) do not have appreciable anti-proliferative effect on the 4T1 and NIH/3T3 cells as the EC(50) values obtained are greater than 50 microg/mL when tested under optimal culture condition. Moreover, the aqueous extract may form mutagenic compound(s) upon the metabolisation by liver enzymes.

Como fazer uma sociologia da singularidade? Autoria e campo literário How to make sociology of singularity? Authorship and literary field

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Andréa Borges Leão

2009-10-01

Full Text Available Se o ponto de partida de uma sociologia do estatuto do criador em literatura é o funcionamento social das obras e das condições de sua produção em um espaço de posicionamentos específi cos, o percurso da análise deve acompanhar a lógica dos valores que fundamenta o trabalho de criação. A moderna atividade literária não escapa às tensões entre a afirrmação dos valores associados à singularidade do indivíduo e as regras coletivas que confi guram e orientam as relações no mundo literário, a exemplo dos poderes de consagração e reconhecimento. Daí os embates entre as formas de comportamento individual e a organização das instituições sociais que regulam o trabalho literário. O objetivo deste artigo é situar o escritor, enquanto sujeito historicamente submetido a um “regime de singularidade”, face à estrutura do campo literário. Para tanto, estabelece um possível diálogo entre a abordagem compreensiva da socióloga Nathalie Heinich e a ciência das obras elaborada por Pierre Bourdieu. Palavras-chave: Campo literário. Singularidade. Autoria literária. Direito do autor. Instituições literárias. If the starting point of sociology of the author statute in literature is the social functioning of the pieces and also the conditions of their production in specifi c space, the way to analysis should follow the logic which is the base of that creation. The modern literary activity isn’t free of the tension between the affi rmation of individual singularity associated value and the collective rules that form and guide the literary world relations, like the ways of acclaim and acknowledgment. From there comes the shock between the ways of individual behavior and the organization of social institutes that set the literary world. The goal of this article is to place the author, while a historical subject of a “singularity regime”, in front of the structure of the literary fi eld. In order to achieve that, the

Standard effective doses for proliferative tumours

International Nuclear Information System (INIS)

Jones, L.C.; Hoban, P.

1999-01-01

This study was undertaken to investigate the treatment schedules used clinically for highly proliferative tumours, particularly with reference to the effects of fraction size, fraction number and treatment duration. The linear quadratic model (with time component) is used here to compare non-standard treatment regimens (e.g. accelerated and hyperfractionated schedules), currently the focus of randomized trials, with each other and some common 'standard regimens'. To ensure easy interpretation of results, two parameters known as proliferative standard effective dose one (PSED 1 ) and proliferative standard effective dose two (PSED 2 ) have been calculated for each regimen. Graphs of PSED 1 and PSED 2 versus potential doubling time (T p ) have been generated for a range of fractionation regimens which are currently under trial in various randomized studies. From these graphs it can be seen that the highly accelerated schedules (such as CHART) only show advantages for tumours with very short potential doubling times. Calculations for most of the schedules considered showed at least equivalent tumour control expected for the trial schedule compared with the control arm used and these values agree quite well with clinical results. These calculations are in good agreement with clinical results available at present. The greater the PSED 1 or PSED 2 for the schedule considered the greater the tumour control, which can be expected. However, as has been seen with clinical trials, this higher cell kill also results in higher acute effects which have proved too great for some accelerated schedules to continue. (author)

“Pajaritas de papel” by Jaime Campmany: a contribution to Spanish literary journalism

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Antonio Fernández Jiménez

2017-05-01

Full Text Available The purpose of this article is to give the reader an overview of Jaime Campmany’s early career as a columnist who wrote literary articles he called ‘Pajaritas de papel’ (folded papers birds, which were published daily in the newspaper Arriba from 1966 to 1970. Due to the excellent quality of his literary writings within the framework of a new type of journalism being developed at the time, ‘Pajaritas de papel’ made a clear contribution to the study of literary journalism near the end of the post-war period in Spain due to his ability to reveal information in his articles at a time when the press was still suffering the impediment of censorship. For that reason and more, we consider his articles to have set a valuable precedent for the exalted status that opinion columns achieved in the decades that followed.

Annotation of toponyms in TEI digital literary editions and linking to the web of data

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Frontini, Francesca

2016-07-01

Full Text Available This paper aims to discuss the challenges and benefits of the annotation of place names in literary texts and literary criticism. We shall first highlight the problems of encoding spatial information in digital editions using the TEI format by means of two manual annotation experiments and the discussion of various cases. This will lead to the question of how to use existing semantic web resources to complement and enrich toponym mark-up, in particular to provide mentions with precise georeferencing. Finally the automatic annotation of a large corpus will show the potential of visualizing places from texts, by illustrating an analysis of the evolution of literary life from the spatial and geographical point of view.

USING AUTHENTIC LITERARY WORKS FOR THE FORMATION OF LEXICAL COMPETENCE OF FUTURE GERMAN LANGUAGE TEACHERS

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Антоніна Палецька-Юкало

2014-10-01

Full Text Available The article deals with the advantages of use of authentic literary works as the main sphere of learning and improvement of foreign language vocabulary.The definition of lexical competence has been suggested. The possibilities for perceiving and analysis of such language phenomena as synonyms, antonyms, polisemic words, lexical links, linguistic clichés non-equivalent and emotionally colored vocabulary of authentic literary works as the basis of the formation of German lexical competence of future teachers have been grounded. The process of investigation has revealed that lexical contents of authentic literary works contribute to a comprehensive dictionary and learning connected speech structures, provide frequent repetition of lexical items, and create a sense of language.

Miłosz’s Dialogue with the Literary Centre of the World

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Stanley S. Bill

2012-01-01

Full Text Available In 1986 Bernard Pivot, a French journalist and literary critic, conducted an interview with Miłosz in the television feature called Apostrophes. The conversation was an archetypal example of an encounter between a representative of the “literary centre” and an envoy from what Pascale Casanova later called “une petite littérature”. The present article discusses Miłosz’s contradictory relations with France as a centre of “world’s republic of letters”, against the background of his difficult dialogue with Pivot, and the wider context of Casanova’s theory of inequalities in the literary world. On the one hand, Miłosz felt wiser than French litterateurs, and frequently pointed out to their political naiveness and ignorance of history and the cruel reality of the world. On the other hand, however, Miłosz’s sense of superiority over Western culture was always dialectically linked to the other side of the coin: the rage of a provincial poet at the headquarters of the cultural and economical power.

The Importance of Visual Reading for the Interpretation of a Literary Text

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Janja Batič

2015-12-01

Full Text Available In this paper, the two authors showcase the results of a research survey on the role of illustrations in the interpretation of literary texts. The survey sample included students of primary education and preschool education, who were given the poem Učenjak (Scholar by Niko Grafenauer and asked to answer questions regarding the character’s personality and appearance, the literary space, and other factors. The first group of interviewees was given the poem illustrated by Lidija Osterc and the other the same poem illustrated by Marjan Manček. The results showed that the illustration had a significant impact on the message conveyed by the poem, particularly when the illustrator added the context by representing the character’s environment (which was not explicitly given in the text. Furthermore, the results showed the need for the comprehensive reading of an illustrated text, given that it is the interaction between the verbal and the visual that provides vital information necessary for the reader to understand the message of the dedicated literary work.

Mapping the Demographic Landscape of Characters in Recent Dutch Prose : A Quantitative Approach to Literary Representation

NARCIS (Netherlands)

van der Deijl, Lucas; Pieterse, S.A.; Prinse, Marion; Smeets, Roel

2016-01-01

The lack of ethnic and gender diversity in the Dutch literary domain has recently been subject to discussions in the public debate. In the academic context, questions regarding diversity are studied either on a literary-sociological level (institutional approaches) or on the level of the individual

Synergy among rat T cells in the proliferative response to alloantigen

International Nuclear Information System (INIS)

Wright, P.W.; Loop, S.M.; Bernstein, I.D.

1979-01-01

A synergistic interaction in the proliferative response to alloantigen is described for mixtures of rat thymus and lymph node cells. The optimal conditions for synergy are quantitatively defined. Regression analysis of the slope of the dose-response curve has been utilized to estimate the degree of interaction in thymus--lymph node cell mixtures. The slope of the response of cell mixtures was noted to be significantly greater than the slope for the response of lympth node cells alone. Irradiation was shown to have a differential effect on the response of thymus and lymph node cells in mixtures. Irradiated thymus cells retained the capacity for synergy in mixtures, whereas irradiated lymph node cells did not. Additional studies have demonstrated that both de novo protein synthesis and specific antigen recognition by both responding cell populations in mixtures was required for maximal synergy. These studies demonstrate that synergy cannot be explained as an artifact of altered cell density in vitro. They establish that thymus cells and lymph node cells represent distinct subsets which manifest qualitatively different functions in the proliferative response to alloantigen. Thymus cells can respond directly to alloantigen by proliferation but also have the capacity to amplify the proliferative response of lymph node cells, a capacity which is resistant to X irradiation but requires recognition of alloantigen and de novo protein synthesis. Lymph node cells may similarly respond by proliferation to alloantigen but lack the amplifier activity of thymus cells. Synergy for rat lymphoidcells, like mouse lymphoid cells, has been shown to involve an interaction of thymus-derived lymphocytes

Proliferative activity of benign human prostate, prostatic adenocarcinoma and seminal vesicle evaluated by thymidine labeling

International Nuclear Information System (INIS)

Meyer, J.S.; Sufrin, G.; Martin, S.A.

1982-01-01

The thymidine labeling index (TLI) was measured in vitro in the epithelium and stroma of benign prostate glands and seminal vesicles and in the epithelium of prostatic adenocarcinomas. The mean epithelial TLI of normal peripheral (posterior) prostatic zone was 0.12 per cent, and that of the normal central (deep) zone was 0.11 per cent. Mean normal stromal TLI's were 0.08 per cent and 0.06 per cent, respectively. The mean TLI of epithelium in nodular hyperplasia was 0.31 per cent, which differs significantly from normal epithelium, and the mean stromal TLI was also increased. The mean TLI of prostatic adenocarcinomas was 0.90 per cent (range 0.14 to 3.90 per cent) which was significantly higher than for either normal epithelium or epithelium of nodular hyperplasia. Trends of increasing TLI with increasing histologic grades and increasing nuclear size and numbers of nucleoli were not significant. The data support participation of both epithelial and stromal proliferation in nodular hyperplasia, and indicate a low basal proliferative rate in normal prostatic glands. The low TLI's of prostatic adenocarcinomas relative to other malignancies are consistent with their frequently slowly progressive course. The very low proliferative rate of seminal vesicular epithelium may account for the rarity of seminal vesicular carcinomas

Values and strategies of literary aesthetic appreciation in college English teaching in Chinese campuses

OpenAIRE

Wang, Wen; Guo, Yingjie

2012-01-01

Literary aesthetic appreciation is an indispensable part of college English teaching. As an important content of aesthetic education as well as one of the basic qualities of the compound-type foreign language learners, literary aesthetic appreciation is also an essential part of the college teaching innovation, curriculum construction and training objectives. In the course of students' acquiring aesthetic knowledge, college English teachers need to combine moral education and highlight the va...

Benedito Nunes and the Modern Brazilian Literary Criticism (1946-1969

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Maria de Fátima do Nascimento

2013-08-01

Full Text Available The research analyzes the literary criticism of Benedito Nunes and is divided in two parts. It is based on a variety of textual genres (attempts to write novels, poems, aphorisms, chronicles on science, poetry and philosophy, interviews, criticism on poetry and novels. In other words, on the first texts of Nunes, published in the newspaper “Folha do Norte” (1946-1951, where he started the career as literary critic, in the magazines “Encontro” (1948 and “Norte” (1952, and in other Brazilian newspapers, such as “Jornal do Brasil”, “O Estado de São Paulo” and “O Estado de Minas Gerais”. Nunes’ first books are also analyzed, “O mundo de Clarice Lispector” (1966 and “O dorso do tigre” (1969, for which he was acclaimed one of the exponents of literary criticism in the second half of the 20th century in Brazil, mainly of authors that published from the decade of 1940 on, namely, Clarice Lispector, Guimarães Rosa and João Cabral de Melo Neto. The compilation of texts published in newspapers enables the identification of the main readings of Benedito Nunes, which were incorporated to his work, such as the Christian philosophers, Saint Thomas Aquinas, Pascal and Søren Kierkegaard, who will be constant in the writings of Nunes. The compilation also makes possible to trace the intellectual trajectory of Nunes, especially as literary critic. He after added to his work the ideas of Jean-Paul Sartre and Martin Heidegger. Regarding Heidegger, who Nunes studied throughout his life, it is possible to consider the ontological conception of artistic creation by verbal language, which, according to the German philosopher, corresponds to the foundation of the self by the word. The first part of this research analyzes the intellectual trajectory of Benedito Nunes as well as the material compiled in newspapers and in his first books. The second part presents a sample of the compiled material.

Cervantes and Vargas Llosa. Two literary architectures

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Ángel Pérez Martínez

2017-09-01

Full Text Available From the development of Literature Theory wich based on the analogy with Architecture the author analyze the relationships between Cervantes and Vargas Llosa works. Research on Cervantes reception in Latin America it is a work to keep doing. In Peru Vargas Llosa has received Cervantes works in a peculiar way. This paper tries to clarify what are the structural relations between these two literary architecture

Moroccan Mothers' Involvement in Dialogic Literary Gatherings in a Catalan Urban Primary School: Increasing Educative Interactions and Improving Learning

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de Botton, Lena; Girbés, Sandra; Ruiz, Laura; Tellado, Itxaso

2014-01-01

This article analyses a case study on Moroccan mothers' involvement in the Dialogic Literary Gathering (DLG) in an urban primary school in Catalonia (Spain). DLG is a dialogic learning environment that improves reading skills and communicative abilities and promotes school-community links. This activity has been identified in previous European…

Personal Knowledge Management in the Training of Non-Literary Translators

DEFF Research Database (Denmark)

Kastberg, Peter

2009-01-01

of problems. As Karl Popper states we may even say that a profession is a conglomerate of acknowledged problems and the disciplinary-internal resources with which to solve these problems (Popper 1979[1962]:108). The particular translation problem, which I will be discussing in this paper, was reintroduced...... to us by the German translation scholar Reiss back in the 1980s when she laconically stated that "you cannot translate what you do not understand". In this article I will discuss one particular aspect of this problem, namely how students of non-literary translation are currently taught to reach...... the ground for rethinking how we deal with subject matter in the training of non-literary translators   KEYWORDS   Translator training, translation curricula, subject matter competence, Personal Knowledge Management...

Anti-proliferative activity of 2,6-dichloro-9- or 7-(ethoxycarbonylmethyl)-9H- or 7H-purines against several human solid tumour cell lines.

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Morales, Fátima; Ramírez, Alberto; Conejo-García, Ana; Morata, Cynthia; Marchal, Juan A; Campos, Joaquín M

2014-04-09

As leads we took several benzo-fused seven- and six-membered scaffolds linked to the pyrimidine or purine moieties with notable anti-proliferative activity against human breast, colon and melanoma cancerous cell lines. We then decided to maintain the double-ringed nitrogenous bases and change the other components to the ethyl acetate moiety. This way six purine and two 5-fluorouracil derivatives were obtained and evaluated against the MCF-7, HCT-116, A-375 and G-361 cancer cell lines. Two QSARs are obtained between the anti-proliferative IC₅₀ values for compounds 26-33 and the clog P against the melanoma cell lines A-375 and G-361. Our results show that two of the analogues [ethyl 2-(2,6-dichloro-9H- or 7H-purine-9- or 7-yl)acetates (30 and 33, respectively)] are potent cytotoxic agents against all the tumour cell lines assayed, showing single-digit micromolar IC₅₀ values. This exemplifies the potential of our previously reported purine compounds to qualify as lead structures for medicinal chemistry campaigns, affording simplified analogues easy to synthesize and with a noteworthy bioactivity. The selective activity of 30 and 33 against the melanoma cell line A-375, via apoptosis, supposes a great advantage for a future therapeutic use. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Literary Origins of the Term "School Psychologist" Revisited

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Fagan, Thomas K.

2005-01-01

Previous research on the literary origins of the term "school psychologist" is revisited, and conclusions are revised in light of new evidence. It appears that the origin of the term in the American literature occurred as early as 1898 in an article by Hugo Munsterberg, predating the usage by Wilhelm Stern in 1911. The early references to the…

Cognitive Poetics: Blending Narrative Mental Spaces. Self-Construal and Identity in Short Literary Fiction

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Gabriela Tucan

2013-06-01

Full Text Available The present study seeks to explore some of the major assumptions made by cognitive linguists regarding language in an attempt to see how various language processes can participate in the emergence of literary meaning. Also, this is an attempt to bridge the gap between linguistics and literary studies. For that purpose, linguistic work with a cognitive orientation can open the floor to one highly debatable question in critical literary theory: the question of interpretation. The primary step in order to meet my objectives is the presentation of a model of analysis that investigates the processes of meaning formation in literary texts – the theory of blending seems to be extremely suitable for an account of meaning formation. I believe that my article can profit substantially from the wide array of instruments provided by the blending theory in order to understand the nature of the reader’s mind while reading literary (short stories. The study of the basic mental operation of blending is motivated by the general relationship of cognitive poetics and narrative theories. To this end, I will be extensively making use of the blending framework in order to address its narrative implications in two of Hemingway’s already canonical short stories – Big Two-Hearted River and Soldier’s Home. What I hope to demonstrate is that the conceptualization of the narrative mental spaces in these two short stories always has counterfactuality available and uses it as a valuable mental resource. Also, I will try to show that conceptual integration/ blending plays a central role in the self-construal of characters’ identity.

Anti-proliferative and apoptosis-inducing activity of lycopene against three subtypes of human breast cancer cell lines

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Takeshima, Mikako; Ono, Misaki; Higuchi, Takako; Chen, Chen; Hara, Takayuki; Nakano, Shuji

2014-01-01

Although lycopene, a major carotenoid component of tomatoes, has been suggested to attenuate the risk of breast cancer, the underlying preventive mechanism remains to be determined. Moreover, it is not known whether there are any differences in lycopene activity among different subtypes of human breast cancer cells. Using ER/PR positive MCF-7, HER2-positive SK-BR-3 and triple-negative MDA-MB-468 cell lines, we investigated the cellular and molecular mechanism of the anticancer activity of lycopene. Lycopene treatment for 168 consecutive hours exhibited a time-dependent and dose-dependent anti-proliferative activity against these cell lines by arresting the cell cycle at the G0/G1 phase at physiologically achievable concentrations found in human plasma. The greatest growth inhibition was observed in MDA-MB-468 where the sub-G0/G1 apoptotic population was significantly increased, with demonstrable cleavage of PARP. Lycopene induced strong and sustained activation of the ERK1/2, with concomitant cyclin D1 suppression and p21 upregulation in these three cell lines. In triple negative cells, lycopene inhibited the phosphorylation of Akt and its downstream molecule mTOR, followed by subsequent upregulation of proapoptotic Bax without affecting anti-apoptotic Bcl-xL. Taken together, these data indicate that the predominant anticancer activity of lycopene in MDA-MB-468 cells suggests a potential role of lycopene for the prevention of triple negative breast cancer. PMID:24397737

Proliferative glomerulonephritis and primary antiphospholipid syndrome

International Nuclear Information System (INIS)

Abdalla, H. Abdalla; Kfoury, Hala K.; Al-Khader, Abdulla A.; Al-Suleiman, M.

2006-01-01

Little is known regarding the association of primary antiphospholipid syndrome (APLS) and proliferative glomerulonephiritis (GN). We describe a biopsy-documented case with primary APLS and proliferative (GN) with no evidence of thrombotic microangiopathy (TMA), and in the absence of other manifestations of systematic lupus erythematosus (SLE). She presented initially with left popliteal deep venous thrombosis and nephrotic syndrome. Her first pregnancy at the age of 26 years resulted in the intra-uterine fetal death at term. Two subsequent pregnancies ended up with miscarriages at 3 and 4 months of gestation. Urinalysis revealed glomerular red blood cells of 1.0000.000/ml and granular cast; proteinuria of 13.4grams/24 hours, which was non-selective; hemoglobin 12 gm/dl, normal white blood cell and platelets; serum albumin 2.6gm/dl; anti-nuclear antibody (ANA) and anti DNA were negative and complement levels normal. Lupus anticoagulant was positive leading to a diagnosis of primary APLS. The biopsy findings were consistent with membranoproliferative GN. She continued to have steroid-resistant proteinuria, but stable renal function after a 12-year follow up period. She had 2 pregnancies during this period and was delivered at term using caesarian section. She received heparin during the pregnancies. Later she developed hypertension easily controlled by atenolol. This case provides evidence that primary APLS can be associated with proliferative GN due to immune deposits and not only TMA as previously reported, and in the complete absence of SLE. Performing more renal biopsies in this group of patients may disclose a greater prevalence of proleferative GN and may help in devising a rationale for treatment. (author)

The Relationship between Proliferative Scars and Endothelial Function in Surgically Revascularized Patients

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Murat Ziyrek

2015-12-01

Full Text Available Background: Proliferative scars are benign fibrotic proliferations which demonstrate abnormal wound healing in response to skin injuries. As postulated in the “response to injury hypothesis”, atherosclerosis is also triggered by an endothelial injury. Keloid and atherosclerotic processes have many pathophysiological and cytological features in common. Aims: In this study, we investigated the relationship between proliferative scars and endothelial function in surgically revascularized patients. We aimed to test the hypothesis that atherosclerosis is a wound healing abnormality. Study Design: Cross-sectional study. Methods: Consecutive patients who were admitted to the cardiology outpatient clinic with a history of coronary artery bypass grafting operation were evaluated. Thirty-three patients with proliferative scars at the median sternotomy site formed the keloid group, and 36 age- and sex-matched patients with no proliferative scar at the median sternotomy site formed the control group. Endothelial function was evaluated by flow-mediated vasodilatation of the brachial artery via ultrasonograhic examination. Results: There is no signicant difference according to the demographic data, biochemical parameters, clinical parameters and number of grafts between keloid and control groups. Endothelial-dependent vasodilatory response was lower in the keloid group than the control group (9.30±3.5 and 18.68±8.2, respectively; p=0.001. Conclusion: This study showed that endothalial dysfunction, which is strongly correlated with atherosclerosis, was more prominent in patients with proliferative scars. As proliferative scars and atherosclerosis have many features in common, we might conclude that atherosclerosis is a wound healing abnormality.

The Role of MKP-1 in the Anti-Proliferative Effects of Glucocorticoids in Primary Rat Pre-Osteoblasts.

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Micheline Sanderson

Full Text Available Glucocorticoid (GC-induced osteoporosis has been attributed to a GC-induced suppression of pre-osteoblast proliferation. Our previous work identified a critical role for mitogen-activated protein kinase (MAPK phosphatase-1 (MKP-1 in mediating the anti-proliferative effects of GCs in immortalized pre-osteoblasts, but we subsequently found that MKP-1 null mice were not protected against the pathological effects of GCs on bone. In order to reconcile this discrepancy, we have assessed the effects of GCs on proliferation, activation of the MAPK ERK1/2 and MKP-1 expression in primary adipose-derived stromal cells (ADSCs and ADSC-derived pre-osteoblasts (ADSC-OBs. ADSCs were isolated by means of collagenase digestion from adipose tissue biopsies harvested from adult male Wistar rats. ADSC-OBs were prepared by treating ADSCs with osteoblast differentiation media for 7 days. The effects of increasing concentrations of the GC dexamethasone on basal and mitogen-stimulated cell proliferation were quantified by tritiated thymidine incorporation. ERK1/2 activity was measured by Western blotting, while MKP-1 expression was quantified on both RNA and protein levels, using semi-quantitative real-time PCR and Western blotting, respectively. GCs were strongly anti-proliferative in both naïve ADSCs and ADSC-OBs, but had very little effect on mitogen-induced ERK1/2 activation and did not upregulate MKP-1 protein expression. These findings suggest that the anti-proliferative effects of GCs in primary ADSCs and ADSC-OBs in vitro do not require the inhibition of ERK1/2 activation by MKP-1, which is consistent with our in vivo findings in MKP-1 null mice.

Doubles everywhere: literary contributions to the study of the bodily self.

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Dieguez, Sebastian

2013-01-01

The topic of the double is a hallmark of romantic, gothic, and fantastic literature. In the guise of the second self, the alter ego or the doppelgänger, fictional doubles have long fascinated critics, clinicians, and scientists. We review classical approaches to the theme and propose a broad clinical and neurocognitive framework from which to examine major instances of the motif in literature. Based on neurological disorders of the bodily self (including unilateral and whole body illusions and duplications), as well as related experimental approaches, we provide examples of literary depictions of bodily fragmentation and splitting; autoscopic hallucinations; the classical doppelgänger, second self, or heautoscopic double; the feeling of a presence; out-of-body experiences; and so-called near-death experiences. Examples include works from Guy de Maupassant, E.T.A. Hoffman, Edgar Allan Poe, Robert Louis Stevenson, Fyodor Dostoevsky, Rudyard Kipling, and others. We discuss these literary cases of doubles from a neurocognitive perspective, and suggest that common mechanisms of the bodily self are involved in the emergence of pathological illusory doubles, literary creations of the double, as well as widespread cultural and religious beliefs about the existence of doubles and the soul. Copyright © 2013 S. Karger AG, Basel.

PROSPECTIVE STUDY OF HISTOLOGICAL PROLIFERATIVE CHANGES IN ADJACENT AREAS OF BREAST CANCER

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Rema Nair Sarkar

2016-11-01

Full Text Available BACKGROUND Breast cancer remains a global health problem with an increasing incidence. Proliferative breast diseases are recognised as one of the risk factors in the development of carcinoma. This study was undertaken to know the frequency of proliferative lesions and other lesions in association with breast carcinomas in mastectomy specimens. MATERIALS AND METHODS 100 cases of excised carcinoma breast sent to the Department of Pathology for a three-year period at tertiary care centre was thoroughly examined and changes adjacent to the tumour was recorded and tissue was subjected for histopathological examination and results tabulated. RESULTS Infiltrating duct cell carcinoma, Not Otherwise Specified (NOS type was present in 89% of cases. Among the associated lesions, nonproliferative lesions constituted 16%, proliferative breast disease without atypia 29%, proliferative breast disease with atypia 10% and others 45%. Fibrocystic disease constituted 14% of cases, epithelial hyperplasia 15%, sclerosing adenosis 12% and atypical ductal hyperplasia in 10% of cases. Other types of associated lesions were duct carcinoma in situ in 4 cases. CONCLUSION Proliferative lesions adjacent to carcinoma breast were seen in 39% of cases. Fibrocystic disease, epithelial hyperplasia, sclerosing adenosis and atypical ductal hyperplasia being the commonest lesions adjacent to carcinoma breast in the present study.

Literature and Language Teaching: Exploring Literary Texts with the Language Learner and Re-Creating Literature in the ESL Classroom.

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Lazar, Gillian; Heath, Shirley Brice

1996-01-01

Two educators discuss the role literature plays in the English as a Second Language (ESL) classroom. One emphasizes that literary texts are a source for classroom activities that can motivate learners. The other points out that the English writings of ESL students about their travels and friends published in newsletters and journals generate…

The use of analogy in pro-life argumentation

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Simona Mazilu

2012-11-01

Full Text Available The paper is concerned with how analogy is strategically used in pro-life argumentation on abortion. Pragma-dialectics (van Eemeren and Grootendorst 1992 offers a set of critical questions by means of which I will evaluate the use of the argumentation based on a relation of analogy in terms of dialectical soundness. Examining various pro-life texts, I have noticed that the analogies employed remain unexplained. Therefore, despite the apparent similarities between abortion and the German holocaust or slavery, for instance, there are essential differences which are not mentioned. I claim that these analogies mainly have a rhetorical function, to operate what has been called by Micheli (2007: 960 “a transfer of emotional consensus”.

“Journeys of the mind” in the Russian Cultural Society of the 1760-s. Educational and Publishing activity of Kheraskov Literary Circle

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Natalia D. Bludilina

2016-09-01

Full Text Available This article examines one of the pages of the history of Russian Freemasonry as a philosophical and ideological trend within the circles of reflective minds of the Russian society and its influence on the literary process; in particular, it explores a connection of Freemasonry rationalist philosophy with the “journeys of the mind” in the works of M.M.Kheraskov and his Moscow literary circle (A.P.Sumarokov, A. A.Nartov, A. A.Rzhevsky, Alex and Simon Naryshkin, D. Anichkov, J. I. Bulgakov, V. I.Maikov, and I.F. Bogdanovich that to a certain extent reflected complex processes of the development of spiritual culture in the eighteenth century Russia. For the members of Moscow literary circle, a journal was not only the most efficient way to establish and maintain contacts with the readers but also the means of enlightening contemporaries introducing them to literature. These literati, for the first time in history, developed a group with its own philosophical, political, and literary position: they claimed that enlightened mind creates and perfects a soul that is open to kindness and love and that moral life is based on the awareness of the moral imperative. The essay analyzes didactic essays by the above mentioned authors and their translations (from Montaigne, Fontenelle, Voltaire, Dodsli, and Gellert — a circle of spiritual reading they promoted in chronological order of their publication in the magazines issued in the 1760 ‘s: “Useful Jollification,” “Free Hours,” “Monthly Essays Serving to Instruct and Entertain,” “Idle Time,” and “Hardworking Bee.” As the analysis reveals, they understood enlightenment mainly as self-knowledge and self-improvement of a single individual; intellectual connection was reduced to the narrow circle of single-minded and educated persons. To understand the “laws of the mind” and to build a life of body and soul on their basis was the goal that Russian Freemason authors pursued as they

78 FR 42106 - Certain TV Programs, Literary Works for TV Production and Episode Guides Pertaining to Same...

Science.gov (United States)

2013-07-15

... INTERNATIONAL TRADE COMMISSION [Investigation No. 337-TA-886] Certain TV Programs, Literary Works for TV Production and Episode Guides Pertaining to Same; Institution of Investigation Pursuant to 19 U... of certain TV programs, literary works for TV production and episode guides pertaining to same by...

Wikipedia in Promoting Science Literary Skills in Primary Schools

Science.gov (United States)

Menon, Sunitha; Alias, Norlidah; DeWitt, Dorothy

2014-01-01

In learning Science, online environments allowing for user generated content are becoming increasingly important since they offer possibilities for learners to elaborate on assignments and projects. This study investigates how Wikipedia can serve as a means for enhancing science literary skills when students are encouraged to participate in…

Andalusī Vestiges in the Ethiopian Islamic Literary Tradition

DEFF Research Database (Denmark)

Hernandez-Lopez, Adday

2017-01-01

This contribution constitutes my first approach to the material that has been gathered to date within the research project “Islam in the Horn of Africa: A Comparative Literary Approach” in which I am currently engaged. The analysis of the manuscripts comprising the corpus has put several traces o...

(58 Indices, Metaphors and Montages. The Heterogeneous Work in Current Latin American Literary Studies

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Francisco Gelman Constantin

2017-09-01

Full Text Available As contemporary literary scholars challenge the ruling exclusionary criteria for the homogenization of their objects, while at the same time the biopolitical turn on literary theory criticizes representational understandings of the bond between language and the body, this paper suggests to address said relationship with recourse to the Lacanian notion of the ‘montage of heterogeneous’, which was brought forth toward a redefinition of the psychoanalytical concept of drive. Drawing from the notion of ‘heterogeneous literatures’, I advocate a theoretical genealogy from Bataille to Lacan (while Nancy, Foucault and Butler are also summoned to the discussion in order to come to terms with the rethinking of the objects for literary scholarship demanded by works such as Emilio García Wehbi’s performance piece 58 indicios sobre el cuerpo, along with his and Nora Lezano’s poetical- photographical essay Communitas.

Linguacultural space “Man-Nature” in literary texts: cognitive and pragmatic approach

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Eldarova Ruzanna Alievna

2016-06-01

Full Text Available The magnitude of representation of nature images, the links to the author’s mind, the hero, the reader can be considered in literary texts as one of the most important sources for identifying the parameters of the national picture of the world and the individually author’s transformation of its components. Researches that identify patterns of functioning linguacultural spaces in the texts are able to give new results projected in the linguistic picture of the ethnic group of the world due to reflections in literary texts of archetypal, stereotyped images of peculiar linguistic culture and ethnic group as a whole as well as individually-copyright, which characterize a particular linguistic identity and its conception of the world. Cognitive paradigm of modern linguistics, anthropocentric in nature allows to consider culture as a process modeling language, which naturally highlights the problem of linguistic linguaculture of predetermined value. Great importance in this regard is the concept of space as linguocultural cognitive model of objective reality. Cognitive-pragmatic potential of a literary text is deepening due to the introduction the descriptions of nature, since they always implement the ethical, aesthetic, and intellectual abilities of the creative subject.

Proliferative activity of benign human prostate, prostatic adenocarcinoma and seminal vesicle evaluated by thymidine labeling

International Nuclear Information System (INIS)

Meyer, J.S.; Sufrin, G.; Martin, S.A.

1982-01-01

The thymidine labeling index (TLI) was measured in vitro in the epithelium and stroma of benign prostate glands and seminal vesicles and in the epithelium of prostatic adenocarcinomas. The mean epithelial TLI of normal peripheral (posterior) prostatic zone was 0.12 percent, and that of the normal central (deep) zone was 0.11 percent. Mean normal stromal TLI's were 0.08 percent and 0.06 percent, respectively. The mean TLI of epithelium in nodular hyperplasia was 0.31 percent, which differs significantly from normal epithelium (p less than 0.05), and the mean stromal TLI was also increased (0.16 percent, p less than 0.1). The mean TLI of prostatic adenocarcinomas was 0.90 percent (range 0.14 to 3.90 percent) which was significantly higher than for either normal epithelium (p less than 0.001) or epithelium of nodular hyperplasia (p less than 0.05). Trends of increasing TLI with increasing histologic grades and increasing nuclear size and numbers of nucleoli were not significant. The data support participation of both epithelial and stromal proliferation in nodular hyperplasia, and indicate a low basal proliferative rate in normal prostatic glands. The low TLI's of prostatic adenocarcinomas relative to other malignancies are consistent with their frequently slowly progressive course. The very low proliferative rate of seminal vesicular epithelium (mean TLI 0.02 percent) may account for the rarity of seminal vesicular carcinomas

Potent anti-proliferative effects against oral and cervical cancers of Thai medicinal plants selected from the Thai/Lanna medicinal plant recipe database "MANOSROI III".

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Manosroi, Aranya; Akazawa, Hiroyuki; Pattamapun, Kassara; Kitdamrongtham, Worapong; Akihisa, Toshihiro; Manosroi, Worapaka; Manosroi, Jiradej

2015-07-01

Thai/Lanna medicinal plant recipes have been used for the treatment of several diseases including oral and cervical cancers. To investigate anti-proliferative activity on human cervical (HeLa) and oral (KB) cancer cell lines of medicinal plants selected from Thai/Lanna medicinal plant recipe database "MANOSROI III". Twenty-three methanolic plant crude extracts were tested for phytochemicals and anti-proliferative activity on HeLa and KB cell lines for 24 h by the sulforhodamine B (SRB) assay at the doses of 1 × 10(1)-1 × 10(-6 )mg/ml. The nine extracts with the concentrations giving 50% growth inhibition (GI50) lower than 100 µg/ml were further semi-purified by liquid/liquid partition in order to evaluate and enhance the anti-proliferative potency. All extracts contained steroids/triterpenoids, but not xanthones. The methanolic extracts of Gloriosa superba L. (Colchinaceae) root and Albizia chinensis (Osbeck) Merr. (Leguminosae-Mimosoideae) wood gave the highest anti-proliferative activity on HeLa and KB cell lines with the GI50 values of 0.91 (6.0- and 0.31-fold of cisplatin and doxorubicin) and 0.16 µg/ml (28.78- and 82.29-fold of cisplatin and doxorubicin), respectively. Hexane and methanol-water fractions of G. superba exhibited the highest anti-proliferative activity on HeLa and KB cell lines with the GI50 values of 0.15 (37- and 1.9-fold of cisplatin and doxorubicin) and 0.058 µg/ml (77.45- and 221.46-fold of cisplatin and doxorubicin), respectively. This study has demonstrated the potential of plants selected from MANOSROI III database especially G. superba and A. chinensis for further development as anti-oral and cervical cancer agents.

Treatment and prevention of porcine proliferative enteropathy with oral tiamulin.

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McOrist, S; Smith, S H; Shearn, M F; Carr, M M; Miller, D J

The effect of an oral treatment or prevention programme, incorporating the antibiotic tiamulin, on the development of proliferative enteropathy in experimentally challenged pigs was studied. Twenty weaner pigs were challenged orally with a virulent inoculum of Lawsonia intracellularis strain LR189/5/83, a British isolate of the causative agent of porcine proliferative enteropathy, and seven control pigs were dosed with a buffer solution. Seven of the 20 challenged pigs were left untreated; they gained less weight than the controls and three of them developed mild to moderate diarrhoea two weeks after the challenge. All seven developed lesions, six visible grossly, of proliferative enteropathy, and numerous intracellular L intracellularis were detected in sections of the intestines examined three weeks after the challenge. To test a 'prevention' dosing strategy for tiamulin, six of the challenged pigs were dosed orally with 50 ppm tiamulin, incorporated in a 2 per cent stabilised premix, given from two days before the challenge until they were euthanased. To test a 'treatment' strategy, the remaining group of seven challenged pigs were dosed orally with 150 ppm tiamulin given in the premix from seven days after challenge until they were euthanased. All the control pigs and the 13 pigs treated with tiamulin, either before or after challenge, remained clinically normal and had no specific lesions of proliferative enteropathy in sections of the intestines examined post mortem.

Literary Translation as a Tool for Critical Language Planning

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Mooneeram, Roshni

2013-01-01

This paper argues that Dev Virahsawmy, an author who manipulates literary translation for the purposes of linguistic prestige formation and re-negotiation, is a critical language-policy practitioner, as his work fills an important gap in language planning scholarship. A micro-analysis of the translation of a Shakespearean sonnet into Mauritian…

Social Science and Literary Criticism: What is at stake? | Rohrbaugh ...

African Journals Online (AJOL)

disciplines are being born that all too often leave specialists isolated from each other. While at some points the various methods complement each other, at others they remain contradictory or mutually exclusive. Two of the newer such methods, literary ...

Virginia Woolf's Literary Aesthetics: The Epistemological Aspect

OpenAIRE

Bartkuvienė, Linara

2012-01-01

The thesis focuses on the epistemological aspect of Virginia Woolf‘s literary aethetics. The research problem of the thesis is an attempt at the conceptualization of the nature of knowledge in Woolf‘s writing and Bertrand Russell‘s philosophy. Methodologically and theoretically, the semantic relationship between Woolf‘s aesthetics and Russell‘s epistemology is closely examined within the framework of the history of ideas. The thesis arrives at the conclusion that Woolf‘s understanding of real...

Psychos’ Haunting Memories: A(n (Uncommon Literary Heritage

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Maria Antónia Lima

2015-07-01

Full Text Available In our times, one of the most prevailing forms of terror is certainly the psychological terror. In the history of literature and cinema, it’s impossible to forget some very widely known characters called psychos, especially those created by Edgar Allan Poe, Robert Bloch, Stephen King, Bret Easton Ellis, Sarah Kane and Patrick McGrath. Usually, they are haunted not only by their own private memories, but also by a literary memory that associates them to a common heritage, as if each psychotic character belonged to a very old gothic family, in which every member had been cursed to inherit the disease of his ancestors or the sins of his fathers. Haunted by images of their past, that recurrently return to the present, these psychos defy the barriers of time and all the traditional distinctions between reality and imagination, because one can never be sure if the stories are really about murders or about victims of their very diseased minds. Uncertainties and doubts disturb the reader as they also disturb the main character in search of a lost identity. Keywords: Psychos, Terror, Haunting Memories, Literary Heritage, Poe.

Five Contemporary Novelists' Views of Growing Up Turkish in the 1980s: A Literary Sociology. Occasional Papers. Turkish Studies Series Number Five.

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Stone, Frank Andrews

Literary sociology is a multifaceted process of analyzing texts. It moves beyond traditional literary criticism to incorporate such varied approaches as: appreciating literary schemata; textual analysis; seeking form, sound, and content regularities; examining the lasting values of the work; and contemplating the reader's own authentic life-world…

"Brücke dreht sich um!". A Deconstructionist Reading of Kafka's "Die Brücke"

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Eva Hoffmann

2014-12-01

Full Text Available Franz Kafka's (1883-1924 "Die Brücke" is one of the less well-known texts by one of the most prolific authors of literary modernity. However, this short prose text embodies prevalent questions of literary modernity and philosophy as it reflects the crisis of language in regard of identity, communication, and literary production. Placed in the context of fin-de-siècle's discourse of language crisis, this article provides a dialogue between Kafka's "Die Brücke" and Hannah Arendt's (1906-1975 philosophy of thinking and speaking in The Life of the Mind. Contrary to Arendt's understanding of the metaphor as "a carrying over" between the mental activities of the solitude thinker and a reconciliation with the pluralistic world shared with others, this article argues for a deconstructionist reading of "Die Brücke" as a tool to reevaluate Arendt's notion of a shared human experience ensured through language and illustrates the advantages of poetic texts within philosophical discourses.

Proliferative myositis: a case report

International Nuclear Information System (INIS)

Kim, Young Sook; Jeon, Ho Jong

2002-01-01

We report a case of proliferative myositis arising in the pectoralis major muscle of a 59-year-old man who presented with palpable mass. The initial clinical impression was a malignant tumor. Ultrasonography revealed the lesion as a spindle-shaped hypoechoic mass, and MR imaging of the left pectoralis major muscle showed hypointensity at T1-weighted imaging, hyperintensity at T2-weighted imaging, and strong enhancement at contrast-enhanced T1-weighted imaging

Proliferative myositis: a case report

Energy Technology Data Exchange (ETDEWEB)

Kim, Young Sook; Jeon, Ho Jong [Chosun University College of Medicine, Gwangju (Korea, Republic of)

2002-09-01

We report a case of proliferative myositis arising in the pectoralis major muscle of a 59-year-old man who presented with palpable mass. The initial clinical impression was a malignant tumor. Ultrasonography revealed the lesion as a spindle-shaped hypoechoic mass, and MR imaging of the left pectoralis major muscle showed hypointensity at T1-weighted imaging, hyperintensity at T2-weighted imaging, and strong enhancement at contrast-enhanced T1-weighted imaging.

Children's Acquisition of Literary Genre: Science Fiction versus Fantasy.

Science.gov (United States)

Shechter, Myriam; Schecter, Sandra R.

Using ethnographic observations of 30 children in a multicultural inner-city fifth grade class over a period of one year, a study examined the children's classroom interactions with the literary genres of science fiction and fantasy, investigating their sequential acquisition of the constitutive elements of the two genres as well as their…

Caribbean literary theory: modernist and postmodern

Directory of Open Access Journals (Sweden)

A. James Arnold

1995-01-01

Full Text Available [First paragraph] The Repeating Mand: The Caribbean and the Postmodern Perspective. ANTONIO BENITEZ-ROJO. Durham NC: Duke University Press, 1992. xi + 303 pp. (Cloth US$ 49.95, Paper US$ 15.95 Myth and History in Caribbean Fiction: Alejo Carpentier, Wilson Harris, and Edouard Glissant. BARBARA J. WEBB. Amherst: University of Massachusetts Press, 1992. x + 185 pp. (Cloth US$ 25.00 Caribbean literature has been overtaken of late by the quarrels that have pitted postmodernists against modernists in Europe and North America for the past twenty years. The modernists, faced with the fragmentation of the region that hard-nosed pragmatists and empiricists could only see as hostile to the emergence of any common culture, had sought in myth and its literary derivatives the collective impulse to transcend the divisions wrought by colonial history. Fifteen years ago I wrote a book that combined in its lead title the terms Modernism and Negritude in an effort to account for the efforts by mid-century Caribbean writers to come to grips with this problem. A decade later I demonstrated that one of the principal Caribbean modernists, Aimé Césaire, late in his career adopted stylistic characteristics that we associate with the postmodern (Arnold 1990. The example of Césaire should not be taken to suggest that we are dealing with some sort of natural evolution of modernism toward the postmodern. In fact the two terms represent competing paradigms that organize concepts and data so differently as to offer quite divergent maps of the literary Caribbean.

Promise Okekwe: Rising Star on the Nigerian Literary Horizon ...

African Journals Online (AJOL)

... a young and upcoming talent on the Nigeria literary horizon. Okekwe was first published in 1992. A resilient and dynamic writer, she has continued to produce texts at a pace akin to Buchi Emecheta's. Her works reveal a remarkable understanding of the human mind. She thus aims at a reconstruction of the wider society.

Close Reading of Literary Nonfiction: The Three-Column Journal

Science.gov (United States)

McConn, Matthew

2018-01-01

The Common Core State Standards have placed more emphasis on the close reading of all texts, and have made a point of increasing the use of nonfiction in secondary English classrooms. In this article, the author describes an approach for implementing close reading of literary nonfiction. The approach comes from a small-scale classroom-based…

Measuring Literary Reading Motivation: Questionnaires Design and Pilot Testing

Science.gov (United States)

Chrysos, Michail

2017-01-01

This study aims to present the design and pilot testing procedures of the two specific self-report questionnaires were used to measure the two key aspects of reading motivation, self-efficacy and intrinsic motivation in the field of literary (narrative) reading, and the partial factors that jointly shape them. These instruments were outlined in…

COMPARISONS BETWEEN THE NON-PROLIFERATIVE AND PROLIFERATIVE THERAPY IN FIBROCYSTIC MASTOSIS.

Science.gov (United States)

Carauleanu, A; Socolov, R; Rugina, V; Gabia, O; Carauleanu, Daniela Mihaela; Lupascu, Ivona Anghlcelache; Socolov, Demetra

2016-01-01

Fibrocystic mastosis (FCM) is the most frequent benign breast lesion. Most treatments for fibrocystic mastosis are: hormonl, with beneficial results and non-hormonal, with fluctuating results. A number of 210 cases were studied, which were divided into 7 groups. The study lasted for 9 months and it was carried out on the basis of a personal examination sheet. The following were monitored: age groups, mastodynia, reducing breast nodules, a significant reduction in the volume of the mastosic cysts, reducion of the fibrous tissue, medication tolerance. Mastodynia has declined by 90% in the cases treated with Tamoxifen and Danazol, by 70% in the case of Lynestrenol and Bromocriptine, by 50% in the 15 patients who were given Utrogestan. Knowing the advantages and disadvantages of drugs (contraindications, side effects), age category, breast pain reduction, antiproliferative activity, tolerability, relapse allow us to assess the benefit-risk. Even in those circumstances that remained incompletely clarified for objective reasons, related to the inaccurate/incorrect reporting by the patients, there is a significant difference (p < 0.05) between the frequency of relapses following the treatment with Tamoxifen and the other categories of drugs who were administered. Our study shows that in the groups that were administered Logest, Utrogestan and Bromocriptine, only antalgic effects were achieved (disappearance or only decrease of mastodynia) and no anti-proliferative effects were obtained. Basically, hormone treatment should be made based on a histopathological examination.

Love of poetry and literary creation in Turgenev's 'First love'

NARCIS (Netherlands)

de Haard, E.

2008-01-01

This article discusses poetic insertions and literary references in Turgenev's 'First Love' (1860). Dependent on variable temporal and evaluative points of view, they function as means of characterization, as indices of a mentality of the past (the Romantic 1830s), and as allusions and potential

‘It’s Alive!’ New Materialism and Literary Horror

DEFF Research Database (Denmark)

Sencindiver, Susan Yi

2017-01-01

Pivoting on the primacy of matter as an underexplored question, both new materialist thought and literary Horror’s predilection for probing materialities in lurid detail provide ample purchase for rethinking the matter of matter, and their convergence may open new refreshing lines of inquiry...

Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population.

Science.gov (United States)

Gonzalez-Salinas, Roberto; Garcia-Gutierrez, Maria C; Garcia-Aguirre, Gerardo; Morales-Canton, Virgilio; Velez-Montoya, Raul; Soberon-Ventura, Vidal R; Gonzalez, Victoria; Lechuga, Rodrigo; Garcia-Solis, Pablo; Garcia-Gutierrez, David G; Garcia-Solis, Marco Vinicio; Saenz de Viteri, Manuel; Solis-S, Juan C

2017-01-01

To assess if the included vascular endothelial growth factor (VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus (T2DM). A case-control study was conducted in adult individuals with T2DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study (ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by qPCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts. In total 142 individuals were enrolled, 71 individuals with T2DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021 [OR (95% CI)=0.44(0.08-2.2); P =0.25] and rs2010963 [OR (95% CI)=0.63(0.25-1.6); P =0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r 2 =0.1043, P ≤0.0001; rs3025021 vs rs2010963: D'=0.442, r 2 =0.0446, P =0.149; rs3025035 vs rs2010963: D'=0.505, r 2 =0.0214, P =0.142. This is the first analysis involving VEGF polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations

Vitreous vascular endothelial growth factor concentrations in proliferative diabetic retinopathy versus proliferative vitreoretinopathy.

Science.gov (United States)

Citirik, Mehmet; Kabatas, Emrah Utku; Batman, Cosar; Akin, Kadir Okhan; Kabatas, Naciye

2012-01-01

To assess vitreous vascular endothelial growth factor (VEGF) concentrations in proliferative diabetic retinopathy (PDR) in comparison to proliferative vitreoretinopathy (PVR). Vitreous samples were collected from 69 eyes of 69 patients with traumatic lens dislocation (n = 10), grade B PVR with rhegmatogenous retinal detachment (n = 13), grade C PVR with rhegmatogenous retinal detachment (n = 14), PDR with vitreous hemorrhage (n = 18), and PDR with vitreous hemorrhage and tractional retinal detachment (n = 14). Vitreous fluid samples were obtained at vitrectomy, and the levels of VEGF were measured by enzyme-linked immunosorbent assay. The mean vitreous level of VEGF was 15.14 ± 5.22 pg/ml in eyes with grade B PVR, 99.15 ± 38.58 pg/ml in eyes with grade C PVR, 4,534.01 ± 1,193.28 pg/ml in eyes with vitreous hemorrhage secondary to PDR, 5,157.29 ± 969.44 pg/ml in eyes with vitreous hemorrhage and tractional retinal detachment secondary to PDR, and 16.19 ± 5.76 pg/ml in eyes of the control group with traumatic lens dislocation. Vitreous VEGF concentrations were significantly higher in the patients with grade C PVR, PDR with vitreous hemorrhage and PDR with vitreous hemorrhage and tractional retinal detachment in comparison to the control patients (p < 0.05). A significant alteration was not observed in patients with grade B PVR (p = 0.55). Vitreous VEGF concentrations are increased in PDR and grade C PVR. The high VEGF concentrations could suggest a possible effect of VEGF on advanced PVR. Copyright © 2011 S. Karger AG, Basel.

The League of Extraordinary Gentlemen as (Literary) History

DEFF Research Database (Denmark)

Backe, Hans-Joachim

2017-01-01

Alan Moore and Kevin O’Neill’s series The League of Extraordinary Gentlemen, published since 1999, depicts a world which is populated by characters of fiction, from Allan Quatermain and Captain Nemo to James Bond and Harry Potter. The result is not only a meta-fictional bricolage of cornerstones ...... about the feedback between history and literary history through the lens of comics and the medium’s own development....

Functional aesthetics of literary theory and the conflict of ...

African Journals Online (AJOL)

Because of this, it is generally assumed that the more you grow in your capacity to understand theory, the more you will be able to think broadly and deeply about human experience and the world of ideas, to appreciate this density and shades of meaning available in literary works. But there are so many theories which ...

Language of the Earth: Exploring Natural Hazards through a Literary Anthology

Science.gov (United States)

Malamud, B. D.; Rhodes, F. H. T.

2009-04-01

This paper explores natural hazards teaching and communications through the use of a literary anthology of writings about the earth aimed at non-experts. Teaching natural hazards in high-school and university introductory Earth Science and Geography courses revolves mostly around lectures, examinations, and laboratory demonstrations/activities. Often the results of such a course are that a student 'memorizes' the answers, and is penalized when they miss a given fact [e.g., "You lost one point because you were off by 50 km/hr on the wind speed of an F5 tornado."] Although facts and general methodologies are certainly important when teaching natural hazards, it is a strong motivation to a student's assimilation of, and enthusiasm for, this knowledge, if supplemented by writings about the Earth. In this paper, we discuss a literary anthology which we developed [Language of the Earth, Rhodes, Stone, Malamud, Wiley-Blackwell, 2008] which includes many descriptions about natural hazards. Using first- and second-hand accounts of landslides, earthquakes, tsunamis, floods and volcanic eruptions, through the writings of McPhee, Gaskill, Voltaire, Austin, Cloos, and many others, hazards become 'alive', and more than 'just' a compilation of facts and processes. Using short excerpts such as these, or other similar anthologies, of remarkably written accounts and discussions about natural hazards results in 'dry' facts becoming more than just facts. These often highly personal viewpoints of our catostrophic world, provide a useful supplement to a student's understanding of the turbulent world in which we live.

Post-digital Books and Disruptive Literary Machines

DEFF Research Database (Denmark)

Pold, Søren Bro; Andersen, Christian Ulrik

2014-01-01

Abstract The e-book has been launched several times during the last decades and the book’s demise has often been predicted. Furthermore networked and electronic literature has already established a long history. However, currently we witness several interesting artistic and literary experiments...... of –and critical reflection on post- or semio-capitalism, and furthermore we will discuss how literature functions in a post-industrial software culture such as the one presented by Apple, Amazon and Google. Keywords: digital literature, Kindle, Apple, Ubermorgen, Korabiewski, post-digital, post...

Proliferative diabetic retinopathy is associated with microalbuminuria in patients with type 2 diabetes

Directory of Open Access Journals (Sweden)

M.C. Boelter

2006-08-01

Full Text Available Diabetic retinopathy is one of the leading causes of blindness in working-age individuals. Diabetic patients with proteinuria or those on dialysis usually present severe forms of diabetic retinopathy, but the association of diabetic retinopathy with early stages of diabetic nephropathy has not been entirely established. A cross-sectional study was conducted on 1214 type 2 diabetic patients to determine whether microalbuminuria is associated with proliferative diabetic retinopathy in these patients. Patients were evaluated by direct and indirect ophthalmoscopy and grouped according to the presence or absence of proliferative diabetic retinopathy. The agreement of diabetic retinopathy classification performed by ophthalmoscopy and by stereoscopic color fundus photographs was 95.1% (kappa = 0.735; P < 0.001. Demographic information, smoking history, anthropometric and blood pressure measurements, glycemic and lipid profile, and urinary albumin were evaluated. On multiple regression analysis, diabetic nephropathy (OR = 5.18, 95% CI = 2.91-9.22, P < 0.001, insulin use (OR = 2.52, 95% CI = 1.47-4.31, P = 0.001 and diabetes duration (OR = 1.04, 95% CI = 1.01-1.07, P = 0.011 were positively associated with proliferative diabetic retinopathy, and body mass index (OR = 0.90, 95% CI = 0.86-0.96, P < 0.001 was negatively associated with it. When patients with macroalbuminuria and on dialysis were excluded, microalbuminuria (OR = 3.3, 95% CI = 1.56-6.98, P = 0.002 remained associated with proliferative diabetic retinopathy. Therefore, type 2 diabetic patients with proliferative diabetic retinopathy more often presented renal involvement, including urinary albumin excretion within the microalbuminuria range. Therefore, all patients with proliferative diabetic retinopathy should undergo an evaluation of renal function including urinary albumin measurements.

Polish natural bee honeys are anti-proliferative and anti-metastatic agents in human glioblastoma multiforme U87MG cell line.

Directory of Open Access Journals (Sweden)

Justyna Moskwa

Full Text Available Honey has been used as food and a traditional medicament since ancient times. However, recently many scientists have been concentrating on the anti-oxidant, anti-proliferative, anti-inflammatory and other properties of honey. In this study, we investigated for the first time an anticancer effect of different honeys from Poland on tumor cell line - glioblastoma multiforme U87MG. Anti-proliferative activity of honeys and its interferences with temozolomide were determined by a cytotoxicity test and DNA binding by [H3]-thymidine incorporation. A gelatin zymography was used to conduct an evaluation of metalloproteinases (MMP-2 and MMP-9 expression in U87MG treatment with honey samples. The honeys were previously tested qualitatively (diastase activity, total phenolic content, lead and cadmium content. The data demonstrated that the examined honeys have a potent anti-proliferative effect on U87MG cell line in a time- and dose-dependent manner, being effective at concentrations as low as 0.5% (multifloral light honey - viability 53% after 72 h of incubation. We observed that after 48 h, combining honey with temozolomide showed a significantly higher inhibitory effect than the samples of honey alone. We observed a strong inhibition of MMP-2 and MMP-9 for the tested honeys (from 20 to 56% and from 5 to 58% compared to control, respectively. Our results suggest that Polish honeys have an anti-proliferative and anti-metastatic effect on U87MG cell line. Therefore, natural bee honey can be considered as a promising adjuvant treatment for brain tumors.

Literature as a Network: Creative-Writing Scholarship in Literary Magazines

Science.gov (United States)

Green, Harriett E.

2014-01-01

With the increase in undergraduate and graduate programs for creative writing at institutions of higher education in North America, literary journals and magazines now serve as leading scholarly publishing outlets and research resources for creative-writing faculty and students. This study analyzes ten years of citations from nineteen leading…

Proliferative response of the murine esophageal epithelium to radiation: Modification by food consumption patterns

International Nuclear Information System (INIS)

Burholt, D.R.

1985-01-01

The single layer of proliferative epithelial cells of the murine esophagus undergoes a sequence of damage and recovery following cytotoxic insult. The modification of both damage and proliferative recovery by the alteration of animal eating patterns was investigated following thoracic field irradiation through the determination of /sup 3/H-TdR incorporation into the esophagus along with selective counting of labeled nuclei and mitotic figures. Initial radiation-induced damage, as determined by /sup 3/H-TdR incorporation suppression and mitotic delay, is under normal conditions dependent on the time of day of treatment. This circadian sensitivity may be altered by changing the eating pattern of the animal. The proliferative recovery following single dose irradiation is also dependent on food consumption patterns: fasting immediately following treatment and then refeeding 2 days later results in a more rapid proliferative recovery than observed under control eating conditions, while reduced food consumption during the period of proliferative hyperplasia reduces the extent of recovery. During multifraction radiation schedules both the damage produced by a subsequent dose and recovery capacity are influenced by the food consumption pattern between fractions

F-18-FDG positron emission tomography findings correlate pathological proliferative activity of oral squamous cell carcinoma

International Nuclear Information System (INIS)

Toyoizumi, Osamu; Oriuchi, Noboru; Miyakubo, Mitsuyuki

2010-01-01

It is still controversial whether fluorodeoxyglucose (FDG) uptake is correlated with cellular proliferation and prognosis of oral squamous cell carcinoma (OSC). In this study, we performed positron emission tomography (PET) study and immunohistochemical analysis to elucidate the relationship between FDG uptake and expression of cellular proliferative markers and pathological prognostic markers in patients with OSC. FDG PET and immunohistochemical staining have been carried out in sixteen patients with OSC. Tumor uptake of FDG was expressed with standardized uptake value (SUV). The expression of Ki-67, Topoisomerase IIα (Topo IIα), p53, and p63 in cancer cells was quantitatively assessed with positivity of the immunohistochemical staining. SUV was compared with the results of immunohistochemical analysis. FDG PET study revealed that SUV ranged from 3.6 to 22.1 with average of 10.4. Average positive rate of Ki-67, Topo IIα, p53, and p63 was 68.9%, 58.9%, 72.0%, and 65.2%, respectively. Pearson product-moment correlation coefficient analysis revealed that SUV was significantly correlated with Ki-67 (r=0.616, p=0.01), Topo IIα (r=0.677, p=0.004), p53 (r=0.613, p=0.01), and p63 (r=0.710, p=0.002), respectively. The present preliminary study indicated that FDG uptake was closely correlated with pathological cellular proliferative and prognostic markers in patients with OSC. (author)

The development of proliferative verrucous leukoplakia in oral lichen planus. A preliminary study

Science.gov (United States)

Llorente-Pendás, Santiago; González-Garcia, Manuel; García-Martín, José-Manuel

2016-01-01

Background Was to describe 14 cases of a proliferative verrucous leukoplakia as a clinical evolution of oral lichen planus. Material and Methods The clinical and histopathological characteristics of 14 cases of OLP that progress towards a plaque-like and verrucous form were indicated, with monitoring over a period of six to 24.3 years. Results The female/male ratio was 11/3, (78.6 and 21.4%). The mean age when the first biopsy was undertaken was 56.4 years old. None of the patients smoked during the study. As bilateral reticular was clinically diagnostic criterion, the second most frequent clinical form was the plaque form (n=10; 71.4%), followed by the atrophic (n=6; 42.8%), and erosive forms (n=4; 28.5%). Clinically it spread towards attached gingival mucosa and the hard palate. In the histopathologic study, there were a predominance of hyperkeratosis and verrucous epithelial hyperplasia. Three of the cases progressed to a squamous cell carcinoma, and one patient developed two verrucous carcinoma. Conclusions Further research is needed to demonstrate if proliferative multifocal oral lichen planus and proliferative multifocal oral leukoplakia are the same disorder but have different behaviour of malignancy for reasons of origin. Key words:Oral lichen planus, proliferative verrucous oral leukoplakia, malignant oral lichen planus, multifocal verrucous oral lichen planus, proliferative verrucous oral lichen planus. PMID:27031060

In praise of the literary eponym--Henry V sign.

LENUS (Irish Health Repository)

Shanahan, F

2013-01-01

The use of eponyms in medicine is often discouraged. However, the literary eponym should be an exception as it is not linked with many of the difficulties associated with conventional eponyms and offers descriptive brevity and accuracy. Here, we illustrate the point with Henry V sign, which will be familiar to many who have cared for patients in the terminal stage of illness.

Atypical hyperplasia, proliferative fibrocystic change, and exogenous hormone use.

Science.gov (United States)

Zera, R T; Danielson, D; Van Camp, J M; Schmidt-Steinbrunn, B; Hong, J; McCoy, M; Anderson, W R; Linzie, B M; Rodriguez, J L

2001-10-01

The association between breast cancer development and exogenous hormone use (EHU) is suggested by indirect clinical evidence. We undertook this study to better define the relationship that EHU has with proliferative fibrocystic change (PFC) and atypical hyperplasia (AH). Women diagnosed with AH without associated carcinoma from January 1990 to December 1999 were compared with control subjects who underwent breast biopsy procedures during the same interval and who were diagnosed with either a proliferative fibrocystic change (PFC) or a nonproliferative fibrocystic change (NPFC). EHU was defined as the use of estrogen or progesterone taken together or separately within 3 months of biopsy. EHU was significantly higher in patients with AH compared with women with NPFC (P =.01). This observation was also significant if all proliferative change (both AH and PFC) was compared with NPFC (P =.03); it was not significant when PFC alone was compared with NPFC. No significant difference in EHU was demonstrated between women with AH and those with PFC. There is strong association between AH and EHU. These results support the theory that a continuum exists between hyperplasia and carcinoma and that EHU may influence the transition from one to the other in an undefined subset of women. We encourage our patients with AH to discontinue EHU.

Different proliferative capacity of lung fibroblasts obtained from control subjects and patients with emphysema

NARCIS (Netherlands)

Noordhoek, JA; Postma, DS; Chong, LL; Vos, JTWM; Kauffman, HF; Timens, W; van Straaten, JFM

2003-01-01

To characterize the possible role of a dysregulated proliferative capacity of pulmonary fibroblasts in insufficient tissue repair in lungs from patients with pulmonary emphysema, the authors undertook in vitro proliferative studies with pulmonary fibroblasts obtained from lung tissue of patients

„Hustý popis“ jako literárněvědná metoda? // "Thick description" as a method of literary theory?

Directory of Open Access Journals (Sweden)

Jitka Paitlová

2016-11-01

Full Text Available This paper deals with a selected example of the understanding of the Anglo-Saxon New Historicism by German literary scholars. It focuses on the method of “thick description” as formulated by the American anthropologist Clifford Geertz and as criticized by German literary scholar and ethnologist Thomas Fechner-Smarsly. In connection with the so-called anthropological turn, it consists in the application of ethnology in literary criticism. According to Geertz a semantic density arises from the complexity of described, but Geertz fails to formulate a general theory. Fechner sees a great potential for literary studies in the method of “thick description”, but he criticizes the lack of system in Geertz’, when he is reluctant to formulate a generally applicable model of this method. Fechner therefore calls for contextualization, organization and instantiation methods of “thick description” in literary studies and, moreover, emphasizes the interdisciplinary overlap.

Aesthetic Creativity: Insights from Classical Literary Theory on Creative Learning

Science.gov (United States)

Hellstrom, Tomas Georg

2011-01-01

This paper addresses the subject of textual creativity by drawing on work done in classical literary theory and criticism, specifically new criticism, structuralism and early poststructuralism. The question of how readers and writers engage creatively with the text is closely related to educational concerns, though they are often thought of as…

Walking through the Revolution: A Spatial Reading of Literary Echoes

Science.gov (United States)

Queiroz, Ana Isabel; Alves, Daniel

2015-01-01

This paper presents an embryo of a literary guide on the Carnation Revolution to be explored for educational historical excursions other than leisure and tourism. We propose a historical trail through the centre of Lisbon, city of the Carnation Revolution, called "Walk through the Revolution." The trail aims to reinforce collective…

Music in Serbian literary magazine and Yugoslav ideology

Directory of Open Access Journals (Sweden)

Vasić Aleksandar N.

2004-01-01

Full Text Available It is worth noting that the important journal of the history of Serbian literature and music, the Serbian Literary Magazine (1901 - 1914, 1920 1941, became more Yugoslav-oriented within a relatively short period following its inception. From its early beginning to 1906, the Magazine’s musical critics did not actively express its Yugoslav ideology. But from 1907 there was an increase of interest in both the music and the musicians from Croatia and Slovenia. In 1911 the Croatian Opera spent almost two weeks in Belgrade performing; the composer and musicologist, Miloje Milojević began to develop the idea of union with Slavs from the South in a critical analysis he rendered of their performance. Until the end of the first/old series, SLM highlighted a noticeable number of texts about Croatians and Slovenians: critical reviews of Croatian musical books, concerts of Slovenian artists in Belgrade, score editions of Slovenian music performances of instrument soloists from Zagreb in Belgrade - as well as notes about the musical work of Croatian Academy (Yugoslav Academy of Sciences and Arts, Zagreb. Echoes of rare tours of Serbian musicians in South Slavs cultural centers did not go unheard, either. In the older series of the journal, lasting and two-fold relations had already begun to lean towards Yugoslav ideology. From one side, even before World War I, Yugoslav ideology in the Magazine was accepted as a program objective of Serbian political and cultural elite. On the other, the journal does not appear to have negotiated any of its aesthetic criterion when estimating musical events that came from Zagreb and Ljubljana to Belgrade - at least not "in the name of Yugoslav ideology". In later series of SLM, the Yugoslav platform was being represented as official ideological statehood of newly created Kingdoms of Serbs, Croats and Slovenians (1918, i.e., the Kingdom of Yugoslavia (1929. At that time, the Magazine had occasional literary cooperation from

Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients

DEFF Research Database (Denmark)

Grauslund, J; Green, A; Sjølie, A K

2009-01-01

AIMS/HYPOTHESIS: This study aimed to evaluate the prevalence of retinopathy in long-surviving type 1 diabetic patients. It also investigated the 25 year incidence of proliferative retinopathy and associated risk factors in a Danish population-based cohort. METHODS: A population-based cohort of 727...... type 1 diabetic patients from Fyn County, Denmark, was identified in 1973. In 1981-1982, baseline retinopathy was graded and other risk factors were assessed in 573 patients. Twenty-five years later, 308 patients were still alive. Of these, 201 (65.3%) were re-examined at follow-up in 2007......-2008. RESULTS: The median age and duration of diabetes at follow-up were 58.8 and 43 years, respectively. At follow-up, the prevalence of diabetic retinopathy was 97.0%. Non-proliferative retinopathy was found in 45.8%, and 51.2% had proliferative retinopathy. The 25 year incidence of proliferative retinopathy...

“Journeys are Meaningful” (Travelling, Travellers, Literary Periods, Literary Journeys

Directory of Open Access Journals (Sweden)

Fried István

2015-12-01

Full Text Available If the changes of the “discourse networks” (Aufschreibesysteme from 1800 to 1900 model the relations pertaining to the personality, to the cultural determinedness of technology and personality as well as to their interconnections (Kittler 1995, especially having in view the literary mise en scène, it applies all the more to travelling - setting out on a journey, heading towards a destination, pilgrimage and/or wandering as well as the relationship between transport technology and personality. The changes taking place in “transport” are partly of technological, partly (in close connection with the former indicative of individual and collective claims. The diplomatic, religious, commercial and educational journeys essentially belong to the continuous processes of European centuries; however, the appearance of the railway starts a new era at least to the same extent as the car and the airplane in the twentieth century. The journeys becoming systematic and perhaps most tightly connected to pilgrimages from the Middle Ages on assured the “transfer” of ideas, attitudes and cultural materials in the widest sense; the journeys and personal encounters (of course, taking place, in part, through correspondence of the more cultured layers mainly, are to be highly appreciated from the viewpoint of the history of mentalities and society.

Narrowing Circles : Questions on Autopoiesis and Literary Interpretation after Dietrich Schwanitz

NARCIS (Netherlands)

Lippert, Florian

2009-01-01

The essay deals with possibilities of relating Niklas Luhmann's systems theory, especially his notion of autopoiesis, to the interpretation of literary texts. Beyond the common description of literature as a social (sub)system, it discusses ideas regarding a specific representativity of literature

The semiotics of typography in literary texts. A multimodal approach

DEFF Research Database (Denmark)

Nørgaard, Nina

2009-01-01

to multimodal discourse proposed, for instance, by Kress & Van Leeuwen (2001) and Baldry & Thibault (2006), and, more specifically, the multimodal approach to typography suggested by Van Leeuwen (2005b; 2006), in order to sketch out a methodological framework applicable to the description and analysis...... of the semiotic potential of typography in literary texts....

Art-Literary Interface: The Creative Muse of Uche Okeke Through ...

African Journals Online (AJOL)

While I attempt to underscore the importance of Igbo forklore to the creative enterprise, as exemplified by Achebe and Okeke, I also emphasize the role of Okeke's drawings and literary landmarks in the institutionalization of an artliterary tradition at the department of Fine and Applied Arts of the University of Nigeria Nsukka.

Literary Genres in Poetic Texts from the Dead Sea Scrolls

Science.gov (United States)

Pickut, William Douglas

2017-01-01

Among the texts of the Dead Sea Scrolls, there are four literary compositions that bear the superscriptional designations shir and mizmor. These designations correspond directly to superscriptional designations provided many times in both the now-canonical Psalter and the various witnesses to those texts unearthed at Qumran. On its face, this fact…

Čínská literárnost: pojem a téma // Chinese literariness: concept and theme

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Oldřich Král

2017-05-01

Full Text Available The works of critics as dissimilar, in almost every other respect, as Shklovsky, Tynianov, Vodicka, Paul de Man, etc. show the usefulness of “comparative approach” to the general concept of “literariness”, however heterogeneously it may be put to work. The author of the essay argues that the distinction Literariness vs. Literature corresponds with the idea of autonomous worlds of literariness from the typological point of view in the global inequality; it presents the field of “comparative literature” as a way of reading and re-reading in unexpected ways of devices and vices. Chinese literariness as a typological, historically closed and theoretically productive in-between of Sinology and comparative literature.

Panretinal photocoagulation versus intravitreal injection retreatment pain in high-risk proliferative diabetic retinopathy

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Célia Regina Farias de Araújo Lucena

2013-02-01

Full Text Available PURPOSE: To compare pain related to intravitreal injection and panretinal photocoagulation in the management of patients with high-risk proliferative diabetic retinopathy. METHODS: Prospective study including patients with high-risk proliferative diabetic retinopathy and no prior laser treatment randomly assigned to receive panretinal photocoagulation (PRP group or panretinal photocoagulation plus intravitreal ranibizumab (PRPplus group. In all patients, panretinal photocoagulation was administered in two sessions (weeks 0 and 2, and intravitreal ranibizumab was administered at the end of the first laser session in the PRPplus group. Retreatment was performed at weeks 16 and 32 if active new vessels were detected at fluorescein angiography. Patients in the PRPplus group received intravitreal ranibizumab and patients in the PRP group received 500-µm additional spots per quadrant of active new vessels. After the end of retreatment, a 100-degree Visual Analog Scale was used for pain score estimation. The patient was asked about the intensity of pain during the whole procedure (retinal photocoagulation session or intravitreal ranibizumab injection. Statistics for pain score comparison were performed using a non-parametric test (Wilcoxon rank sums. RESULTS: Seventeen patients from PRPplus and 14 from PRP group were evaluated for pain scores. There were no significant differences between both groups regarding gender, glycosylated hemoglobin and disease duration. Mean intravitreal injection pain (±SEM was 4.7 ± 2.1 and was significantly lower (p<0.0001 than mean panretinal photocoagulation pain (60.8 ± 7.8. Twelve out of 17 patients from the PRPplus group referred intensity pain score of zero, while the minimal score found in PRP group was found in one patient with 10.5. CONCLUSION: In patients with high-risk proliferative diabetic retinopathy who needed retreatment for persistent new vessels, there was more comfort for the patient when retreatment

Apocalypse Now: elements of the Literary Journalism in thecinematographic construction by Vietnan War

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Gisele Krodel Rech

2015-06-01

Full Text Available One of the most revered films of war, Apocalypse Now presentes fragments of journalistic representation of reality within a narrative film. They are analogies of the book Dispatches, by Michael Herr, book from the New Journalism phenomenon, which served to support the contextualization of Coppola’s masterpiece process. The intention of this paper is therefore analise the film seeking to find in these analogies textual elements of ekphrasis and fanopeia. In this process, in which the literary journalism narrative is enmeshed in film narrative, non fiction and representation of reality arises intermittently through the fictional work, in a process fraught with imagetic connotative meanings, designed from the power of text of literary journalism.

Proliferative activity of vervet monkey bone marrow-derived adherent cells

International Nuclear Information System (INIS)

Kramvis, A.; Garnett, H.M.

1987-01-01

Vervet monkey bone marrow-derived adherent cell population cultured in Fischer's medium supplemented with 12.5% fetal calf serum and 12.5% horse serum consists of two cell shapes: fusiform (type I) and polygonal (type II). Limiting-dilution cloning of the cells suggested that the two morphologically distinct cell types belong to the same cellular system even though they differ in their proliferative capabilities. The labeling index of type II cells, as measured by autoradiography, was found to be consistently lower than that of type I cells. It is probable that these two phenotypes represent different stages of differentiation, where progenitor type I gives rise to type II cells. The bone marrow-derived adherent cells were found to be cytokinetically at rest in vivo, using the thymidine suicide test, and relatively radioresistant with a D0 = 2.1 Gy and n = 2.36 at the time of explantation from the bone. Furthermore, in culture these cells are characterized by a relatively long cell cycle of 60 h, where the length of the S phase is 30 h, G2 is 12 h, M is 6 h, and G1 is 12 h. Thus, the vervet monkey bone marrow-derived adherent cells represent a cell population with a low turnover rate both in vivo and in vitro

Edward Said’s Worldliness, Amateurism and Heterotopia: Negotiating the Interdisciplinarity of Literary Theory, Canonicity, and Paradigm

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Ayman Abu-Shomar

2016-06-01

Full Text Available Literary criticism nowadays is essentially crossing the boundaries of disciplinarity and canonicity where literary theory has increasingly been shaped by overlapping concepts and branching out of theories as well as whipping out the limitations imposed by theory itself. The post-conditions of contemporaneity have imposed a view of reading and analysing the literary text that is dynamic, proliferated and in flux as well as resistant to monolithic critique and confined disciplines and professionalization. This outlook has increasingly made the notions of literary criticism, theoretical paradigms and canons not only artificial and irrelevant to our materialistic world, but, in many cases, ‘violent’ to those whose life concerns exist in the margins of these paradigmatic notions. In this essay, I argue that those of us who aspire to an interdisciplinary and a metacritical analyses would be well served by importing inspirations from Edward Said’s work, scholarship and life, particularly drawing on his ‘Worldliness’, ‘Amateurism’ and ‘Heteroglossia’ (or heterotopia as well as drawing examples from his negotiation with intellectual paradoxes and tensions informed by his positionality as a border crosser intellectual (or his exilic consciousness. Specifically, this article engages with Said as an author of a radically secular body of work marked by as comportment towards being, and as an example of an “amateur” critic who “speak[s] truth to power”. It argues that Said instates a critically-interrogative scholarship as antidote to essentialist, politicised, determinist and hegemonic literary canons (whether those of texts or theory which are paradigmatically informed by relations of power in academia. The paper argues that through the investment of his scholarship and personal life, Said rejects academic institutions and affiliations with their tendency towards doctrinaire assumptions of critical work. Further to this, Said�

latin American literary testimony: historical foreshadowing of gender in the revolutionary discourse of the sixties

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Victoria García

2015-06-01

Full Text Available The foundation of testimonio in Latin American literary field, initiated at the end of the ‘60, makes part of the institutionalization of the Cuban revolution, process where its projection to the rest of Latin America constitued a central problem. This paper studies political preconditions of testimonio. In particular, it analizes certain aspects of Cuban revolutionary discourse that anticipate features eventually developed by the literary genre, in the ways the relation between literature and politics is represented, and in the subjects of discourse that are proposed as embodiments of such relation. The paper introduces the question of Cuban revolution, as regards the exemplary status it acquired in Latin America during the sixties. Then, it examines the literary positioning represented by testimonio, as the corollary of a reflexive reconsideration operated by some Latin American writers and critics, concerning their historical role. Finally, it considers three representative documents of Cuban revolution and its continental projection: History will absolve me, by Fidel Castro, and Reminiscences of the Cuban revolutionary war and Bolivian diary, by Ernesto Guevara. We show the textual configuration of a revolutionary subject whose legitimity emerges not only from a political experience which testimony enunciates, but also from particular ways of living and representing literature in the context of a revolutionary practice. In the end of the sixties, the continental literary field would reaffirm such features as its discourse legitimating criteria, during the institutionalization of testimonio as its privileged genre.

Comments on 'Standard effective doses for proliferative tumours'

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Dasu, Iuliana Livia; Dasu, Alexandru; Denekamp, Juliana; Fowler, Jack F.

2000-01-01

We should like to make some comments on the paper published by Jones et al (1999). The paper presents some interesting and useful contributions on the theoretical evaluation of different fractionated schedules used now. The use of the linear quadratic equation has been very useful in focusing attention on the differences in fractionation responses of fast and slow proliferating normal tissues and tumours. Unfortunately the BED 10 or BED 3 units for (α/β ratios of 10 Gy and 3 Gy respectively) do not directly relate to anything used in routine clinical practice. The purpose of the paper by Jones et al (1999) is to covert any new schedule into the equivalent total dose as if it was given in the same size fractions as are in common use in that department. They illustrate that, if proliferation is taken into account for the altered schedule, it can be compared in two ways with the standard conventional schedule: (a) the proliferative standard effective dose one (PSED 1 ) in which the proliferation correction is applied in the altered schedule, but not in the standard schedule; (b) the proliferative standard effective dose two (PSED 2 ) in which the proliferation correction is applied to both schedules using the same proliferation parameters. This is expected to provide a better evaluation of the response of a 'real' tumour (i.e. a tumour that also proliferates during the standard treatment). However, there seem to be two errors in the paper. First, the authors quoted a wrong equation for calculating the proliferative standard effective dose two (PSED 2 ) (equations (2) and (A6) in their paper). There are also some special cases with respect to the time available for proliferation and the duration of the treatment that have been neglected in their paper and which require further specification. Therefore, we should like to give the full mathematical derivation of the correct equations for calculating the proliferative standard effective doses. We would also like to make

CHRISTMAS AND EASTER THEMES IN THE LITERARY HERITAGE OF YURIY MIROLYUBOV

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Sergey F. Dmitrenko

2015-11-01

Full Text Available A  Russian emigrant writer Yuri Mirolyubov (1892—1970 wrote a  lot about Slavic antiquities. His name is associated with the origin of a  legendary “The book of Veles”  (Velesova kniga. This article studies his literary works in a historical and literary context, thematically associated with Christmas and Easter. The son of a priest, Mirolyubov was able to create original Christmas and Easter tales. As a priest’s son Mirolyubov managed to create indigenous Christmas and Easter stories. He brought back an already existing genre tradition of Christmas and Easter literature to its folklore origins, freed it from absolutely literary accretions and narrative stereotypes. Yuri Mirolyubov strived to put the Christmas and Easter stories beyond moral (much less entertaining literature, put them in the mainstream of a  folk, “Russian epic” (Ivan Shmelyov. That was a defi nition given by an author Ivan Shmelyov to his writing “The Lord’s summer”  (Leto Gospodne, who also updated the Canon of Russian calendar (Christmas and Easter literature in his own way. In fictional prose Yuri Mirolyubov acted as a scientist-ethnographer, a  sensitive receptionist of  everyday phenomena and psychological states. But in the works defi ned as scientific, he became a true artist, who felt free to deal with the most complicated and poorly studied material, however, existing in the depths of people’s consciousness.

Physical activity and its correlation to diabetic retinopathy.

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Praidou, Anna; Harris, Martin; Niakas, Dimitrios; Labiris, Georgios

2017-02-01

The lack of physical activity, along with obesity, smoking, hypertension and hyperglycaemia are considered as risk factors for the occurrence of diseases such as diabetes. Primary objective of the study was to investigate potential correlation between physical activity and diabetic retinopathy. Three hundred and twenty patients were included in the study: 240 patients with diabetes type 2 (80 patients with mild to moderate non-proliferative diabetic retinopathy, 80 patients with severe to very severe non-proliferative diabetic retinopathy and 80 ones with proliferative diabetic retinopathy) were compared with 80 non-diabetic patients (control group). Physical activity of patients was assessed by the international physical activity questionnaire (IPAQ, 2002). HbA1c and BMI were also measured in diabetic patients. Group comparisons were attempted for levels of physical activity and sedentary behavior. Total physical activity was decreased in patients with severe to very severe non-proliferative diabetic retinopathy and proliferative diabetic retinopathy as compared to patients with mild to moderate non-proliferative diabetic retinopathy and to the control group (pdiabetic retinopathy and physical activity has been demonstrated (pdiabetic retinopathy, independent of the effects of HbA1c and BMI. Copyright © 2016 Elsevier Inc. All rights reserved.

Dysregulation of T lymphocyte proliferative responses in autoimmunity.

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Sydney K Elizer

Full Text Available T cells are critically dependent on cellular proliferation in order to carry out their effector functions. Autoimmune strains are commonly thought to have uncontrolled T cell proliferation; however, in the murine model of autoimmune diabetes, hypo-proliferation of T cells leading to defective AICD was previously uncovered. We now determine whether lupus prone murine strains are similarly hyporesponsive. Upon extensive characterization of T lymphocyte activation, we have observed a common feature of CD4 T cell activation shared among three autoimmune strains-NOD, MRL, and NZBxNZW F1s. When stimulated with a polyclonal mitogen, CD4 T cells demonstrate arrested cell division and diminished dose responsiveness as compared to the non-autoimmune strain C57BL/6, a phenotype we further traced to a reliance on B cell mediated costimulation, which underscores the success of B cell directed immune therapies in preventing T cell mediated tissue injury. In turn, the diminished proliferative capacity of these CD4 T cells lead to a decreased, but activation appropriate, susceptibility to activation induced cell death. A similar decrement in stimulation response was observed in the CD8 compartment of NOD mice; NOD CD8 T cells were distinguished from lupus prone strains by a diminished dose-responsiveness to anti-CD3 mediated stimulation. This distinction may explain the differential pathogenetic pathways activated in diabetes and lupus prone murine strains.

Framing Egypt : Roman literary perceptions of Egypt from Cicero to Juvenal

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Leemreize, M.E.C.

2016-01-01

This is a comprehensive study of Roman literary references to Egypt without preference for one particular period, author or subject, in contrast to most previous scholarship. In doing so, it shows that these references vary greatly, are context-dependent, and cannot be rightly understood when

Fibrinolysis and proliferative endarteritis: two related processes in chronic infections? The model of the blood-borne pathogen Dirofilaria immitis.

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Javier González-Miguel

Full Text Available The interaction between blood-borne pathogens and fibrinolysis is one of the most important mechanisms that mediate invasion and the establishment of infectious agents in their hosts. However, overproduction of plasmin (final product of the route has been related in other contexts to proliferation and migration of the arterial wall cells and degradation of the extracellular matrix. We have recently identified fibrinolysis-activating antigens from Dirofilaria immitis, a blood-borne parasite whose key pathological event (proliferative endarteritis is produced by similar mechanisms to those indicated above. The objective of this work is to study how two of this antigens [actin (ACT and fructose-bisphosphate aldolase (FBAL] highly conserved in pathogens, activate fibrinolysis and to establish a relationship between this activation and the development of proliferative endarteritis during cardiopulmonary dirofilariasis. We demonstrate that both proteins bind plasminogen, enhance plasmin generation, stimulate the expression of the fibrinolytic activators tPA and uPA in endothelial cell cultures and are located on the surface of the worm in contact with the host's blood. ELISA, western blot and immunofluorescence techniques were employed for this purpose. Additionally, the implication of lysine residues in this interaction was analyzed by bioinformatics. The involvement of plasmin generated by the ACT/FBAL and plasminogen binding in cell proliferation and migration, and degradation of the extracellular matrix were shown in an "in vitro" model of endothelial and smooth muscle cells in culture. The obtained results indicate that ACT and FBAL from D. immitis activate fibrinolysis, which could be used by the parasite like a survival mechanism to avoid the clot formation. However, long-term overproduction of plasmin can trigger pathological events similar to those described in the emergence of proliferative endarteritis. Due to the high degree of

A Model for Teaching Literary Analysis Using Systemic Functional Grammar

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McCrocklin, Shannon; Slater, Tammy

2017-01-01

This article introduces an approach that middle-school teachers can follow to help their students carry out linguistic-based literary analyses. As an example, it draws on Systemic Functional Grammar (SFG) to show how J.K. Rowling used language to characterize Hermione as an intelligent female in "Harry Potter and the Deathly Hallows."…

The proliferative human monocyte subpopulation contains osteoclast precursors

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Lari, Roya; Kitchener, Peter D; Hamilton, John A

2009-01-01

Introduction Immediate precursors of bone-resorbing osteoclasts are cells of the monocyte/macrophage lineage. Particularly during clinical conditions showing bone loss, it would appear that osteoclast precursors are mobilized from bone marrow into the circulation prior to entering tissues undergoing such loss. The observed heterogeneity of peripheral blood monocytes has led to the notion that different monocyte subpopulations may have special or restricted functions, including as osteoclast precursors. Methods Human peripheral blood monocytes were sorted based upon their degree of proliferation and cultured in macrophage colony-stimulating factor (M-CSF or CSF-1) and receptor activator of nuclear factor-kappa-B ligand (RANKL). Results The monocyte subpopulation that is capable of proliferation gave rise to significantly more multinucleated, bone-resorbing osteoclasts than the bulk of the monocytes. Conclusions Human peripheral blood osteoclast precursors reside in the proliferative monocyte subpopulation. PMID:19222861

SCIENCE FICTION IN HISTORICAL AND CULTURAL LITERARY DISCOURSE

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Simona Siderevičiūtė

2014-04-01

Full Text Available This work intends to complement literary studies in science fiction. It discusses the history of global science fiction, overviews the most cha­racteristic features of its historical periods, and provides an introduction to Lithuanian science fiction, indicating its main features and topics. In the context of culture, science fiction is often defined as a literary genre with the emphasis on its nature as fiction. Only rarely are the history of the origin of science fiction, its variations, and the pioneers of science fiction whose works are still highly valued taken into account. Science fiction is often criticized through the filter of preconceived ideas that consider this type of literature to be “friv­olous.” This article discusses the possible reasons for such an approach. In Lithuania, this genre is still associated only with pop literature, and its expression cannot yet equal the works of foreign authors. The basic classical motifs of global science fiction found in Lithuanian science fiction include: representatives of extraterrestrial civilizations and human contact with them, scientists and inventors, agents of military institutions, and space travel. Lithuanian science fiction writers follow the tra­ditions of global science fiction when using these classical motifs; however, a general lack of original and individual themes, motifs, and manifestations may be observed.

Literary Fiction Influences Attitudes Toward Animal Welfare.

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Wojciech Małecki

Full Text Available Literary fiction has been credited with considerable power to improve attitudes toward outgroups. It was even argued that it has been an important factor behind the global decline of violence against various minorities in the last centuries. Could it also help to reduce the human-inflicted suffering of animals? To test this, we studied the attitude toward animal welfare of n = 921 (experimental group people of both sexes who read a short fragment of an unpublished novel with a motif of the physical abuse of an animal. The control group (n = 912 read a fragment of a similar length but not related to animals. After reading the text all subjects filled out an on-line questionnaire with seven items (camouflaged among many others items measuring attitudes toward animal welfare. The questionnaire included also demographical questions, such as whether the subject keeps pets. We found that in comparison with the control group, the experimental group was significantly more concerned about animal welfare. This result indicates that literary fiction can influence attitudes toward other species. It is also worth noting that our study is characterized by a high level of ecological validity, i.e. a relatively high extent to which its results can be generalized (or extended to real-world settings. Due to its specific design, which involved the cooperation of a bestselling author and his publisher, the study approximated the typical conditions in which people read fiction in a remarkably accurate way. Finally, our research has potential practical implications for promoting animal welfare.

Literary Fiction Influences Attitudes Toward Animal Welfare.

Science.gov (United States)

Małecki, Wojciech; Pawłowski, Bogusław; Sorokowski, Piotr

2016-01-01

Literary fiction has been credited with considerable power to improve attitudes toward outgroups. It was even argued that it has been an important factor behind the global decline of violence against various minorities in the last centuries. Could it also help to reduce the human-inflicted suffering of animals? To test this, we studied the attitude toward animal welfare of n = 921 (experimental group) people of both sexes who read a short fragment of an unpublished novel with a motif of the physical abuse of an animal. The control group (n = 912) read a fragment of a similar length but not related to animals. After reading the text all subjects filled out an on-line questionnaire with seven items (camouflaged among many others items) measuring attitudes toward animal welfare. The questionnaire included also demographical questions, such as whether the subject keeps pets. We found that in comparison with the control group, the experimental group was significantly more concerned about animal welfare. This result indicates that literary fiction can influence attitudes toward other species. It is also worth noting that our study is characterized by a high level of ecological validity, i.e. a relatively high extent to which its results can be generalized (or extended) to real-world settings. Due to its specific design, which involved the cooperation of a bestselling author and his publisher, the study approximated the typical conditions in which people read fiction in a remarkably accurate way. Finally, our research has potential practical implications for promoting animal welfare.

Literary Depictions i n Ghazavâtnâmahs That Adress the Crimean War

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Kürşat Şamil ŞAHİN

2015-07-01

Full Text Available The Crimean War that started in 1853 between the Ottoman Empire and Russia lasted until 1856. It ended with the defeat of the Russians as England and France sided with the Ottoman Empire. A great number of work has been written then and since about this war which deeply affect our social and politica l life. Among these, there are ghazavâtnâmahs that describe what happened down - to - line, usually by the pen of the poets and writers who closely witnessed the war. The causes of war, the preparations, what happened at the time of expedition and measures tha t were taken, the outcome of the events during the war and afterwards are all brought into sharp relief in most of these works. Whether in verse, prose or mixed typed, these works of art have gradually increased after 15 th century in Turkish literature. Th is genre has decreased by the Ottoman Empire began to decline and the raids were scarce; and it totally disappeared after the tradition of ghaza were ceased. In this study the literary depictions in - the last examples of the genre - Salih Hayri’s Kırım Zafe rnamesi (Hayrâbât, Ahmed Rızâ Trabzonî’s Manzume - i Sivastopol and Süleyman Şâdî’s Muzaffernâme are presented. There are not many studies that focus on literary depictions in ghazavâtnâmahs, particularly on literary war depictions. The characteristics of t hese literary depictions are tried to be explained with reference to ghazavâtnâmahs belonging to the Empire's last era.

Does a single session of reading literary fiction prime enhanced mentalising performance? Four replication experiments of Kidd and Castano (2013).

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Samur, Dalya; Tops, Mattie; Koole, Sander L

2018-02-01

Prior experiments indicated that reading literary fiction improves mentalising performance relative to reading popular fiction, non-fiction, or not reading. However, the experiments had relatively small sample sizes and hence low statistical power. To address this limitation, the present authors conducted four high-powered replication experiments (combined N = 1006) testing the causal impact of reading literary fiction on mentalising. Relative to the original research, the present experiments used the same literary texts in the reading manipulation; the same mentalising task; and the same kind of participant samples. Moreover, one experiment was pre-registered as a direct replication. In none of the experiments did reading literary fiction have any effect on mentalising relative to control conditions. The results replicate earlier findings that familiarity with fiction is positively correlated with mentalising. Taken together, the present findings call into question whether a single session of reading fiction leads to immediate improvements in mentalising.

Social identity and literary genres. Birth and Death of the Stil Nuovo’s sodality

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Paolo Borsa

2017-05-01

Full Text Available The article considers the literary production of Dante Alighieri – and, in parallel, of his “first friend” Guido Cavalcanti – between the composition of the Vita nuova and Dante’s exile. It aims to show that the conflict between Dante and Cavalcanti can also be situated on the level of the representation that the two poets give of themselves in their work, through their chosen poetics and literary genres. Despite having the reputation of a philosophus, the magnate Guido shows his aristocratic disdain even in literary options: he depicts himself as a knight-poet and focuses solely on the representation and analysis of the phenomenology of love. On the contrary, from the Vita nuova on, Dante does not present himself to his audience as only an exquisite and aristocratic love poet, but also – and explicitly – as an expert in physiology, philosophy, and rhetoric. On the model of Guittone d’Arezzo and Brunetto Latini, when he enters Florentine political life, he attributes a civic and ethical function to his poetry, which definitively breaks with the “stilnovistic” poetics of his juvenile association with Cavalcanti.

Differential expression of follistatin and FLRG in human breast proliferative disorders

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Amaral Vania F

2009-09-01

Full Text Available Abstract Background Activins are growth factors acting on cell growth and differentiation. Activins are expressed in high grade breast tumors and they display an antiproliferative effect inducing G0/G1 cell cycle arrest in breast cancer cell lines. Follistatin and follistatin- related gene (FLRG bind and neutralize activins. In order to establish if these activin binding proteins are involved in breast tumor progression, the present study evaluated follistatin and FLRG pattern of mRNA and protein expression in normal human breast tissue and in different breast proliferative diseases. Methods Paraffin embedded specimens of normal breast (NB - n = 8; florid hyperplasia without atypia (FH - n = 17; fibroadenoma (FIB - n = 17; ductal carcinoma in situ (DCIS - n = 10 and infiltrating ductal carcinoma (IDC - n = 15 were processed for follistatin and FLRG immunohistochemistry and in situ hybridization. The area and intensity of chromogen epithelial and stromal staining were analyzed semi-quantitatively. Results Follistatin and FLRG were expressed both in normal tissue and in all the breast diseases investigated. Follistatin staining was detected in the epithelial cytoplasm and nucleus in normal, benign and malignant breast tissue, with a stronger staining intensity in the peri-alveolar stromal cells of FIB at both mRNA and protein levels. Conversely, FLRG area and intensity of mRNA and protein staining were higher both in the cytoplasm and in the nucleus of IDC epithelial cells when compared to NB, while no significant changes in the stromal intensity were observed in all the proliferative diseases analyzed. Conclusion The present findings suggest a role for follistatin in breast benign disease, particularly in FIB, where its expression was increased in stromal cells. The up regulation of FLRG in IDC suggests a role for this protein in the progression of breast malignancy. As activin displays an anti-proliferative effect in human mammary cells, the

SGML-Based Markup for Literary Texts: Two Problems and Some Solutions.

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Barnard, David; And Others

1988-01-01

Identifies the Standard Generalized Markup Language (SGML) as the best basis for a markup standard for encoding literary texts. Outlines solutions to problems using SGML and discusses the problem of maintaining multiple views of a document. Examines several ways of reducing the burden of markups. (GEA)

92 A Literary Discourse of Nigerian Children's Accretive Songs (Pp ...

African Journals Online (AJOL)

Nekky Umera

Observation in the past ten years or so shows that some systematic studies of the lore as a ... The importance of these kind of songs is the “training of the participants to ... more.... This game song is usually performed with the view to establishing the most ... context; the literary impact of the song and the predicament of the.

Implication of Copyright Provisions for Literary Works in Films and ...

African Journals Online (AJOL)

The emphasis of copyright is on original literary works, films, sound recordings and others. The focus of this paper is to discuss the various provisions of the copyright law as they affect films, video and by extension video CD. The study examines the various interpretations of the provisions of the copyright law as they affect ...

The Use of ?Literary Fiction? to Promote Mentalizing Ability

OpenAIRE

Pino, Maria Chiara; Mazza, Monica

2016-01-01

Empathy is a multidimensional process that incorporates both mentalizing and emotional sharing dimensions. Empathic competencies are important for creating interpersonal relationships with other people and developing adequate social behaviour. The lack of these social components also leads to isolation and exclusion in healthy populations. However, few studies have investigated how to improve these social skills. In a recent study, Kidd and Castano (2013) found that reading literary fiction i...

The Literary Criticism and Memoirs of Juan Ramón Jiménez

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Allen W. Phillips

1983-01-01

Full Text Available Equally as demanding of others as he was of himself, Juan Ramón Jiménez conceived of literary criticism as a serious and exacting task. The critic and the poet, standing side by side, are devoted to complementary activities of mutual enrichment. However fragmentary and partial the critical opinions of Juan Ramón may be (also outspoken and polemical in nature, they are invaluable as a personal historical and aesthetic guide to about fifty or sixty years of Hispanic literary development (1900-1960. Not to take them into account is to fail to recognize a highly important aspect of his total artistic personality. These varied critical texts are a product of a first rate intelligence and the sensibility of a writer of consummate discrimination who was endowed not only with an excellent memory but also a very special talent for appreciating the authentic. Juan Ramón as a critic is quick to praise (San Juan, Bécquer, Dario, Unamuno and Machado and at the same time strong in his censure of certain contemporaries. Several recently collected volumes of miscellaneous critical materials have resolved the bibliographical muddle for the initial study of this fundamental aspect of the poet, but still particularly important are the expressionistic portraits of Españoles de tres mundos , longer tributes to Valle, Ortega and Villaespesa as well as the extensive lectures delivered in his latter years. Examination of these pages gives us an historical and creative overview of the period in which he lived and worked in addition to original considerations about the evolution of Hispanic poetry. Of course, one of the constant focal points of his literary criticism was the modernist epoch of his early days, a movement or attitude which he considered to be a modern twentieth century renaissance. Together with detailed study of these two areas of historical and aesthetic nature, in the ensuing pages some conclusions are pointed out as to the essence of poetry

Evaluation of cell proliferative activity after irradiation using immunohistochemical approach and flow cytometry

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Tamada, Takashi (Okayama Univ. (Japan). School of Medicine)

1992-06-01

To evaluate a proliferative activity of post-irradiated malignant cells, we studied the kinetics of HeLa cells using immunohistochemical approach and flow cytometry. HeLa cells were stained with two proliferation-associated monoclonal antibodies, Ki-67 and anti-DNA polymerase {alpha} antibody. Nucleoli of non-irradiated cells were granularly stained with Ki-67. After irradiation, only the center of nuclei was diffusely stained with Ki-67. One hundred forty-four hours after low-dose irradiation, the staining patterns became the same as the control. On the other hand, after high-dose irradiation, the center of nuclei was weakly stained. DNA polymerase {alpha} was diffusely labelled with nuclei of the control. It was located around the border of nuclei of low-dose irradiated cells like a ring. But after high-dose irradiation, it was granularly distributed in the periphery of nuclei. FITC conjugated Ki-67/PI two parameter analysis was done by a single laser flow cytometer. Twenty-four hours after irradiation, DNA-histograms showed the accumulation to G{sub 2}/M phase and the increase of DNA content of G{sub 2}/M cells, as exposure dose was increased. Two parameter analysis showed the increase of FITC uptake of G{sub 2}/M phase as dose increased. These changes of flow cytometry were remarkably observed after 24 hours' incubation. It was shown that the difference of Ki-67 antigen and DNA polymerase {alpha} appearance depended on the irradiation dose. These findings suggest that immunohistochemical staining with Ki-67 or anti-DNA polymerase {alpha} antibody and flow cytometry using Ki-67 are available to evaluate cell damages after irradiation. (author).

ON THE «PROPFECIES» OF HELLEN WHITE AS MODELS OF LITERARY «VISIONS» AND FUNDAMENTAL BELIEVES OF ADVENTISM

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Vladimir Yakovlevich Laluev

2016-02-01

Full Text Available The purpose of research is to analyze the prophecies of Ellen White about the future, as examples of literary vision and the basic tenets of Adventism. In this sense, her two books «Experiences and visions» and «Spiritual Gifts» representing the genre of «literary visions», dating back to V. Leglend and Dante are especially representative. It is here that the doctrinal concepts of contemporary Adventism were formed.The methodological base of the research served as: the historical formation of Religious Studies, Ontopsychology, Culture Studies.The interdisciplinary approach allowed the philosophical and cognitive analysis of prophetic texts of Ellen White to rise to the level of scientific and identify it in a prophetic vision, the samples of literary and artistic creation. Summarizing, it is concluded that a great help in the development of this exclusive material had been influenced by spiritual experiences of Christian mystics: Saint Ephrem, V. Leglenda, I. Floris, Dante J. Boehme, E. Swedenborg, and so on. This is an incomplete number of authors, who can be attributed to the genre of literary visions.

Eco-friendly synthesis, in vitro anti-proliferative evaluation, and 3D-QSAR analysis of a novel series of monocationic 2-aryl/heteroaryl-substituted 6-(2-imidazolinyl)benzothiazole mesylates.

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Racané, Livio; Ptiček, Lucija; Sedić, Mirela; Grbčić, Petra; Kraljević Pavelić, Sandra; Bertoša, Branimir; Sović, Irena; Karminski-Zamola, Grace

2018-04-17

Herein, we describe the synthesis of twenty-one novel water-soluble monocationic 2-aryl/heteroaryl-substituted 6-(2-imidazolinyl)benzothiazole mesylates 3a-3u and present the results of their anti-proliferative assays. Efficient syntheses were achieved by three complementary simple two-step synthetic protocols based on the condensation reaction of aryl/heteroaryl carbaldehydes or carboxylic acid. We developed an eco-friendly synthetic protocol using glycerol as green solvent, particularly appropriate for the condensation of thermally and acid-sensitive heterocycles such as furan, benzofuran, pyrrole, and indole. Screening of anti-proliferative activity was performed on four human tumour cell lines in vitro including pancreatic cancer (CFPAC-1), metastatic colon cancer (SW620), hepatocellular carcinoma (HepG2), and cervical cancer (HeLa), as well as in normal human fibroblast cell lines. All tested compounds showed strong to moderate anti-proliferative activity on tested cell lines depending on the structure containing aryl/heteroaryl moiety coupled to 6-(2-imidazolinyl)benzothiazole moiety. The most potent cytostatic effects on all tested cell lines with [Formula: see text] values ranging from 0.1 to 3.70 [Formula: see text] were observed for benzothiazoles substituted with naphthalene-2-yl 3c, benzofuran-2-yl 3e, indole-3-yl 3j, indole-2-yl 3k, quinoline-2-yl 3s, and quinoline-3-yl 3t and derivatives substituted with phenyl 3a, naphthalene-1-yl 3b, benzothiazole-2-yl 3g, benzothiazole-6-yl 3h, N-methylindole-3-yl 3l, benzimidazole-2-yl 3n, benzimidazole-5(6)-yl 3o, and quinolone-4-yl 3u with [Formula: see text] values ranging from 1.1 to 29.1 [Formula: see text]. Based on obtained anti-proliferative activities, 3D-QSAR models for five cell lines were derived. Molecular volume, molecular surface, the sum of hydrophobic surface areas, molecular mass, and possibility of making dispersion forces were identified by QSAR analyses as molecular properties that are

ICT and Architectural Theory and History: from Literary Discourse to Design Paradigms?

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Proveniers, A.G.W.J.; Gelting, A.K.; Harder, E

2008-01-01

Design Studio Practice in the ICT— Google Era As a jury on Architectural projects we all recognise the unpleasant feeling when we hear a too highly polished student ICT-presentation: the plan does not correspond with the literary plea.

Modifying the explanation of Anvari Abivardi’s literary theory

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Fatemeh Hakima

2016-01-01

Full Text Available   Abstract   In the first place, the literary theory is about finding an answer to the question on what makes a verbal message into a work of art . This is related to the particular distinction of Lingual arts from other arts, and other types of Lingual behaviors . That is why literary theory is in the first position among literary studies. (Ahmadi, 1996: 1st volume/77 One of the fundamental aspects of literary studies is interpreting ancient texts from the perspective of the poet or writer’s own literary theory . On this basis, this article aims to discuss the literary theory and poetry structure of Anvari . Indisputably, Anvari’s structure is special and it is certainly based on the perspective, insight and cultural and social conditions in which it grew and formed. Each poet is the composer of their poetry and oratory and Anvary, himself, is the most informed person about his elocution method. He mentioned the elocution method in several places in his Divan:   However, you looking into poetry styles   All taken into account the best style is mine (Anvari, 1958: 1st volume/85   Accordingly, his Divan has been subjected to scrutiny, and judgment criteria have been derived from the verses of the poet .   Anvari believed that poetry is the result of integrating content with discourse whose output is captured hearts . He called poets the granters of speech and in composing poetry, he believed content is prior to discourse. He has an opinion that the container of discourse does accommodate content that on this basis he approached the ideas of " modern hermeneutics ”. He praised original meaning- which was not adopted by other poems- and he described proper poetry using graceful and delicate characteristic. In fact, in his viewpoint, a poem which has original meaning and graceful and delicate verse is a literary discourse which influences the reader .  From his viewpoint:  1- Improvisation and spontaneity �

Automatic non-proliferative diabetic retinopathy screening system based on color fundus image.

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Xiao, Zhitao; Zhang, Xinpeng; Geng, Lei; Zhang, Fang; Wu, Jun; Tong, Jun; Ogunbona, Philip O; Shan, Chunyan

2017-10-26

Non-proliferative diabetic retinopathy is the early stage of diabetic retinopathy. Automatic detection of non-proliferative diabetic retinopathy is significant for clinical diagnosis, early screening and course progression of patients. This paper introduces the design and implementation of an automatic system for screening non-proliferative diabetic retinopathy based on color fundus images. Firstly, the fundus structures, including blood vessels, optic disc and macula, are extracted and located, respectively. In particular, a new optic disc localization method using parabolic fitting is proposed based on the physiological structure characteristics of optic disc and blood vessels. Then, early lesions, such as microaneurysms, hemorrhages and hard exudates, are detected based on their respective characteristics. An equivalent optical model simulating human eyes is designed based on the anatomical structure of retina. Main structures and early lesions are reconstructed in the 3D space for better visualization. Finally, the severity of each image is evaluated based on the international criteria of diabetic retinopathy. The system has been tested on public databases and images from hospitals. Experimental results demonstrate that the proposed system achieves high accuracy for main structures and early lesions detection. The results of severity classification for non-proliferative diabetic retinopathy are also accurate and suitable. Our system can assist ophthalmologists for clinical diagnosis, automatic screening and course progression of patients.

Spains Dramatic Conquest of the Dutch Republic. Rodenburgh as a Literary Mediator of Spanish Culture

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Tim Vergeer

2016-12-01

Full Text Available Theodore Rodenburgh was in an exceptional position to become a literary mediator of Spanish poetics. He introduced the comedia nueva in the Dutch Republic at the beginning of the seventeenth century. This article investigates specifically how Rodenburgh dealt with Lope de Vega’s poetics, transforming them to make them fit the Dutch literary tradition. Through translation, adaptation and acculturation, the Iberian comedias became Dutch tragicomedies, plays that would become most popular in the Dutch Republic. Rodenburgh’s endeavours mark the initial phase of the transfer of the comedia nueva to the Dutch Republic.

Border Crossing in Contemporary Brazilian Culture: Global Perspectives from the Twenty-First Century Literary Scene

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Cimara Valim de Melo

2016-06-01

Full Text Available Abstract: This paper investigates the process of internationalisation of Brazilian literature in the twenty-first century from the perspective of the publishing market. For this, we analyse how Brazil has responded to globalisation and what effects of cultural globalisation can be seen in the Brazilian literary scene, focusing on the novel. Observing the movement of the novelists throughout the globe, the reception of Brazilian literature in the United Kingdom and the relations between art and the literary market in Brazil, we intend to provoke some reflections on Brazilian cultural history in the light of the twenty-first century.

A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19ARF-p53 signaling

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Shvarts, A.; Brummelkamp, T.; Koh, E.; Daley, G.Q.; Bernards, R.A.

2002-01-01

Senescence limits the proliferative capacity of primary cells in culture. We describe here a genetic screen to identify genes that allow bypass of this checkpoint. Using retroviral cDNA expression libraries, we identify BCL6 as a potent inhibitor of senescence. BCL6 is frequently activated in

A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling

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Shvarts, Avi; Brummelkamp, Thijn R.; Scheeren, Ferenc; Koh, Eugene; Daley, George Q.; Spits, Hergen; Bernards, René

2002-01-01

Senescence limits the proliferative capacity of primary cells in culture. We describe here a genetic screen to identify genes that allow bypass of this checkpoint. Using retroviral cDNA expression libraries, we identify BCL6 as a potent inhibitor of senescence. BCL6 is frequently activated in

A Predictive Model for Estimation Risk of Proliferative Lupus Nephritis

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Dong-Ni Chen

2018-01-01

Conclusion: This study developed and validated a model including demographic and clinical indices to evaluate the probability of presenting proliferative LN to guide therapeutic decisions and outcomes.

Defending the multiverse — or down to crisis on infinite earths. Better: for a literary Na-tional Geographic

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Bianca Campello Rodrigues Costa

2011-06-01

Full Text Available What is the role of literary history in face of its own object: keep the memory of the texts produced during a time gap, texts which, by definition, are endowed of multiple meanings? How to organize the report of existence of texts whose identity is unstable, since it’s being, it’s identity is a joint of meanings attributed to them by the cultural body that faces those texts? From such questions, this article performs a critical review of the theoretical procedures which are classically used for the historical approach of literary texts. Then, it is proposed the adoption of a critical perspective for the historian of literature challenged by the task of ensuring to the literary text the property that keeps it alive throughout the years: the staying power of meaning.

Readings on American Society. The Audio-Lingual Literary Series II.

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Imamura, Shigeo; Ney, James W.

This text contains 11 lessons based on an adaptation of the 1964 essay "Automation: Road to Lifetime Jobs" by A.H. Raskin and 14 lessons based on an adaptation of John Fischer's 1948 essay "Unwritten Rules of American Politics." The format of the book and the lessons is the same as that of the other volumes of "The Audio-Lingual Literary Series."…

English Syllabus Interpretation: The Relationship between Literary Theories and Teacher Beliefs

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Ireland, Jill; O'Sullivan, Kerry-Ann; Duchesne, Susan

2017-01-01

This paper examines the relationship between the literary theories underpinning an English syllabus and teachers' personal epistemologies and pedagogical beliefs. The study discussed here used semi-structured interviews and an online survey to investigate 50 New South Wales teachers' views of the theoretical basis of a senior English syllabus that…

Cetuximab-Associated Crescentic Diffuse Proliferative Glomerulonephritis

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Sukesh Manthri

2017-01-01

Full Text Available Cetuximab-induced nephrotoxicity is very rare, occurring in less than 1% of colorectal cancer patients and not defined in other populations. We report a rare case of crescentic diffuse proliferative glomerulonephritis (GN that developed in close temporal association with cetuximab treatment. A 65-year-old female recently completed chemotherapy with cetuximab treatment for moderately differentiated oral squamous cell carcinoma. She was admitted with acute renal failure and nephrotic-range proteinuria. Laboratory data showed serum creatinine of 6.6 mg/dl and urinalysis showed proteinuria, moderate hemoglobinuria, hyaline casts (41/LPF, WBC (28/HPF, and RBC (81/HPF. Serologic studies were negative for ANA, anti-GBM, ANCA, hepatitis B, and hepatitis C. Serum C3 and C4 level were normal. Renal biopsy showed crescentic diffuse proliferative GN with focal features of thrombotic microangiopathy. Patient was started on cyclophosphamide and steroids. Her renal function did not improve on day 8 and she was started on hemodialysis. Previous reports suggest that EGFR-targeting medications can possibly trigger or exacerbate an IgA-mediated glomerular process leading to renal failure. This case suggests that cetuximab therapy may have triggered or exacerbated a severe glomerular injury with an unfavorable outcome. Treating physicians should maintain a high degree of caution and monitor renal function in patients on EGFR inhibitors.

Authorship attribution and author profiling of Lithuanian literary texts

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Kapočiūtė-Dzikienė, Jurgita; Utka, Andrius; Šarkutė, Ligita

2015-01-01

In this work we are solving authorship attribution and author profiling tasks (by focusing on the age and gender dimensions) for the Lithuanian language. This paper reports the first results on literary texts, which we compared to the results, previously obtained with different functional styles and language types (i.e., parliamentary transcripts and forum posts). Using the Naïve Bayes Multinomial and Support Vector Machine methods we investigated an impact of...

Narrative Journalism in the Age of the Internet. New Ways to Create Authenticity in Online Literary Reportages

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Nora Berning

2011-11-01

Full Text Available Online literary reportages represent an imperative counterweight to conventional journalism that is essential both for our emotional and intellectual survival. Using Paula Delgado-Kling’s online literary reportage Child Soldiers: Homero and Mark Bowden’s multimedia text The Desert One Debacle as examples, Nora Berning explores issues of multimediality and authenticity in online narrative journalism. Berning’s case studies open up discussions, both theoretical and practical, about the future of digital media literacy.

Labouring Under The Stone—A Literary Legacy of Lithiasis

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Moran, Michael E.

2007-04-01

The history of mankind's suffering greatly from calculus disease has been one of excruciating longevity. Since the first historical records, humans have formed stones and endured the wrath of these concretions' passage via the delicate mechanisms of the urinary tract. This study involved detailed investigations of historical writings of famous stone sufferers to better appreciate the circumstances of our patients. Collected histories both of textbooks and articles were scrutinized for the accounts of famous stone sufferers. Once identified, primary resources were sought with English translations given preference. Cross-referencing all informational sources was attempted. The accounts were then classified as lower urinary tract (BS), upper urinary tract (KS), by century of the individual, and whether these were ancient (before 100 years ago) or recent (from the 20th Century onwards). Many of these great men and woman suffered in relative silence. Not much is available on descriptions of their colic. However, there are others such as Michel Montaigne, Erasmus of Rotterdam, Benjamin Franklin, Thomas Sydenham, Sir William Osler and Richard Selzer who were able to transform their suffering into ethereal expressions of pure pain and suffering. The ancient descriptions are twofold fascinating, as the victims of stone disease faced quackery and profound ignorance from the medical profession and no effective remedy for the pain. Here again, there are two typical responses: the enlightened cerebral concerns of Montaigne, Sydenham, and Franklin versus the punitive, religious overtones from Erasmus and Pepys. Lower and upper tract stones produced equal horrors to those once thought to incur punishment from the gods, or turning to stone-like "living statues." No amount of literary expression can capture the true essence of renal colic. Medical texts from their earliest times place stone passage near the top of the pantheon of medical suffering. Each of these prolific and

T.S. ELIOT'S MISREADING OF SOME LITERARY SOURCES IN THE WASTE LAND

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Liem Satya Limanta

2002-01-01

Full Text Available A poet cannot be a poet at all if he is not connected with all the poetic tradition before him. This is T.S. Eliot's dictum which he stated in Tradition and the Individual Talent and which he practiced in his work The Waste Land. T.S. Eliot showed his relationship with the past through all the quotations and allusions to mythical, literary, and religious works. His reading of those sources according to Paul de Man cannot avoid misreading or misinterpretation. Harold Bloom has tried to build up a theory of misreading, which he prefers to call misprision, especially applied to and done by poets in The Anxiety of Influence. Throughout this article I shall show how T.S. Eliot has applied some of the ways Bloom describes in reading some of the literary sources, and by so doing Eliot has given new meaning to them.

Reading, Trauma and Literary Caregiving 1914-1918: Helen Mary Gaskell and the War Library.

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Haslam, Sara

2018-03-28

This article is about the relationship between reading, trauma and responsive literary caregiving in Britain during the First World War. Its analysis of two little-known documents describing the history of the War Library, begun by Helen Mary Gaskell in 1914, exposes a gap in the scholarship of war-time reading; generates a new narrative of "how," "when," and "why" books went to war; and foregrounds gender in its analysis of the historiography. The Library of Congress's T. W. Koch discovered Gaskell's ground-breaking work in 1917 and reported its successes to the American Library Association. The British Times also covered Gaskell's library, yet researchers working on reading during the war have routinely neglected her distinct model and method, skewing the research base on war-time reading and its association with trauma and caregiving. In the article's second half, a literary case study of a popular war novel demonstrates the extent of the "bitter cry for books." The success of Gaskell's intervention is examined alongside H. G. Wells's representation of textual healing. Reading is shown to offer sick, traumatized and recovering combatants emotional and psychological caregiving in ways that she could not always have predicted and that are not visible in the literary/historical record.

Phrasal units in literary translation (the case of idioms in Miguel Delibes Las ratas

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Manuel Sevilla Muñoz

2013-12-01

Full Text Available In this article we explore the translation of phrasal units in the context of literary translation, arguing that such units may fulfil a specific function in a work. This is the case in the novel Las ratas, by Miguel Delibes, in which the author used them as linguistic markers of the social strata and cultural level of the different characters. We have analysed the translation of some idioms of the novel in order to highlight the key aspects to take into account in the translation, the problems that the translator has to face when performinghis profession, and the solutions that can be proposed. We show that thetranslation of phrasal units is certainly not a straightforward task, and thecorrespondences cover a wide range because of the differences between thetwo languages and the numerous factors which need to be taken into account when translate a phrasal unit in a literary text, none of which seems to prevailover the others in all situations. These difficulties compel the translator to study in advance how the author of a literary work uses the phrasal units in order to plan the translation process so that the effect of the phrasal units ofthe original text is also recreated as far as possible in the translation.

The Changing Vocabulary of Literature : On the Migration and Transformation of Literary Concepts in Europe (1900–1950) – an Introduction

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Verstraeten, Pieter; Van den Bossche, Bart

2015-01-01

The central premise of the series of essays presented here is that a full understanding of the wide range of factors in literary change should take into account and carefully analyze the interaction between transformations of literary repertoires on the one hand and contemporary conceptual

The Actualization of Literary Learning Model Based on Verbal-Linguistic Intelligence

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Hali, Nur Ihsan

2017-01-01

This article is inspired by Howard Gardner's concept of linguistic intelligence and also from some authors' previous writings. All of them became the authors' reference in developing ideas on constructing a literary learning model based on linguistic intelligence. The writing of this article is not done by collecting data empirically, but by…

Literariness and Racial Consciousness in Paule Marshall’s Memoir Triangular Road and Gloria Naylor’s Fictionalized Memoir 1996

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Łobodziec Agnieszka

2015-12-01

Full Text Available Black American women writers were side-lined by the literary canon as recently as the 1980s. Today, as a result of their agency, a distinct literary tradition that bears witness to black women’s particular expressiveness is recognized. Bernard Bell observes that the defining features common to most literary works by black American women are a focus on racist oppression, black female protagonists, the pursuit of demarginalization, women’s bonding, women’s relationship with the community, the power of emotions, and black female language. Although these elements refer predominantly to novels, they are also present in Paule Marshall’s memoir Triangular Road (2009 and Gloria Naylor’s fictionalized memoir 1996 (2005. Moreover, the two works are fitting examples of racial art, the point of departure of which, according to Black Arts Movement advocates, should be the black experience. Actually, since through memoirs the authors offer significant insights into themselves, the genre seems closer to this objective of racial art than novels. At the same time, taking into consideration the intricate plot structures, vivid images, and emotional intensity, their memoirs evidence the quality of literariness i.e., in formalist terms, the set of features that distinguish texts from non-literary ones, for instance, reports, articles, text books, and encyclopaedic biographical entries. Moreover, Marshall and Naylor utilize creative imagination incorporating fabulation, stories within stories, and people or events they have never personally encountered, which dramatizes and intensifies the experiences they relate. In Marshall’s memoir, the fictitious elements are discernable when she imagines the historical past. Naylor demarks imagined narrative passages with separate sections that intertwine with those based upon her actual life experience.

Anti-proliferative activity of the quassinoid NBT-272 in childhood medulloblastoma cells

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Helson Lawrence

2007-01-01

Full Text Available Abstract Background With current treatment strategies, nearly half of all medulloblastoma (MB patients die from progressive tumors. Accordingly, the identification of novel therapeutic strategies remains a major goal. Deregulation of c-MYC is evident in numerous human cancers. In MB, over-expression of c-MYC has been shown to correlate with anaplasia and unfavorable prognosis. In neuroblastoma – an embryonal tumor with biological similarities to MB – the quassinoid NBT-272 has been demonstrated to inhibit cellular proliferation and to down-regulate c-MYC protein expression. Methods To study MB cell responses to NBT-272 and their dependence on the level of c-MYC expression, DAOY (wild-type, empty vector transfected or c-MYC transfected, D341 (c-MYC amplification and D425 (c-MYC amplification human MB cells were used. The cells were treated with different concentrations of NBT-272 and the impact on cell proliferation, apoptosis and c-MYC expression was analyzed. Results NBT-272 treatment resulted in a dose-dependent inhibition of cellular proliferation (IC50 in the range of 1.7 – 9.6 ng/ml and in a dose-dependent increase in apoptotic cell death in all human MB cell lines tested. Treatment with NBT-272 resulted in up to 90% down-regulation of c-MYC protein, as demonstrated by Western blot analysis, and in a significant inhibition of c-MYC binding activity. Anti-proliferative effects were slightly more prominent in D341 and D425 human MB cells with c-MYC amplification and slightly more pronounced in c-MYC over-expressing DAOY cells compared to DAOY wild-type cells. Moreover, treatment of synchronized cells by NBT-272 induced a marked cell arrest at the G1/S boundary. Conclusion In human MB cells, NBT-272 treatment inhibits cellular proliferation at nanomolar concentrations, blocks cell cycle progression, induces apoptosis, and down-regulates the expression of the oncogene c-MYC. Thus, NBT-272 may represent a novel drug candidate to inhibit

Foxing the Child: The Cultural Transmission of Pedagogical Norms and Values in Dutch Rewritings of Literary Classics for Children 1850-1950

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Parlevliet, Sanne

2012-01-01

This article examines the reciprocity between children's literature and educational ideals in Dutch rewritings of international literary classics published for children between 1850 and 1950. It analyses the assumed pedagogical power of rewritings of international literary classics for children from the perspective of three theoretical concepts:…

Cultural variation is part of human nature : Literary universals, context-sensitivity, and "shakespeare in the bush".

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Sugiyama, Michelle Scalise

2003-12-01

In 1966, Laura Bohannan wrote her classic essay challenging the supposition that great literary works speak to universal human concerns and conditions and, by extension, that human nature is the same everywhere. Her evidence: the Tiv of West Africa interpret Hamlet differently from Westerners. While Bohannan's essay implies that cognitive universality and cultural variation are mutually exclusive phenomena, adaptationist theory suggests otherwise. Adaptive problems ("the human condition") and cognitive adaptations ("human nature") are constant across cultures. What differs between cultures is habitat: owing to environmental variation, the means and information relevant to solving adaptive problems differ from place to place. Thus, we find differences between cultures not because human minds differ in design but largely because human habitats differ in resources and history. On this view, we would expect world literature to express both human universals and cultural particularities. Specifically, we should expect to find literary universality at the macro level (e.g., adaptive problems, cognitive adaptations) and literary variation at the micro level (e.g., local solutions to adaptive problems).

Geoffrey Keynes's Two-Fold Vision: Medical Savant-Connoisseur and Literary Bibliographer.

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Kutcher, Gerald

2016-10-01

During the 1920s and 1930s, the British surgeon Geoffrey Keynes (1887-1982) treated breast cancer with radium instead of the hegemonic radical mastectomy, while vehemently attacking the "radicalists" for mutilating women. Keynes was also a leading bibliographer of literary figures from Sir Thomas Browne to William Blake through Jane Austen. This article argues that these endeavors did not inhabit separate worlds, but rather his bibliographic methods of collecting and sorting were deeply interwoven with his therapeutic practices and medical ways of knowing. The article also examines the profound influence his engagement with the works of William Blake had on his battle against the reigning medical orthodoxy and on the humanity of his relationship with his patients. It concludes that Keynes' story sheds light on a now distant medico-cultural world where literary studies, often centered on book collecting and critique, were not only highly valued, but were influential in guiding the vision and behavior of a number of physicians. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Combining Machine Learning and Natural Language Processing to Assess Literary Text Comprehension

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Balyan, Renu; McCarthy, Kathryn S.; McNamara, Danielle S.

2017-01-01

This study examined how machine learning and natural language processing (NLP) techniques can be leveraged to assess the interpretive behavior that is required for successful literary text comprehension. We compared the accuracy of seven different machine learning classification algorithms in predicting human ratings of student essays about…

Empirical based theory about literary development and differentiation in upper-secondary schools

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Witte, T. C. H.; Rijlaarsdam, G. C. W.; Schram, D. H.

2010-01-01

In the process of literary socialization in upper-secondary schools, adolescents learn to respond to literature in accordance with the examination syllabus. Two of the major problems teachers of literature have to deal with are 1) how they can deliver instructions and implement their goals to

VISUAL OUTCOME FOLLOWING PANRETINAL PHOTOCOAGULATION IN PROLIFERATIVE DIABETIC RETINOPATHY

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Nellaye Mani Sindhu

2018-01-01

Full Text Available BACKGROUND Diabetes mellitus can be called as a noninfectious pandemic and the incidence of diabetic retinopathy is also uncontrollable. This vision-threatening complication can be treated by early diagnosis and effective treatment like panretinal photocoagulation. The aim of the study is to evaluate the effect of panretinal photocoagulation on visual acuity, colour vision, contrast sensitivity and severity of visual field changes. MATERIALS AND METHODS Prospective study of visual outcome following panretinal photocoagulation in patients with proliferative diabetic retinopathy conducted in Retina Clinic, RIO, Trivandrum, during the time period one year from April 2008. Inclusion Criteria- Eyes with proliferative diabetic retinopathy, visual acuity better than or equal to 6/60, a follow up of at least 6 months after panretinal photocoagulation. Exclusion Criteria- Eyes with cataractous changes in the lens, eyes, which would be undergoing or have undergone focal photocoagulation eyes, which undergone barrage or sectoral retinal photocoagulation, patients with colour blindness, eyes with vitreous haemorrhage and macular preretinal haemorrhage, glaucomatous patients with peripheral field loss. RESULTS The mean age of the patients was 52 years. Male patients (30 outnumbered the female patients (23. Mean duration of diabetes was 14.42 years. Though, there is a statistically significant reduction in visual acuity in the first followup, which was improved and stabilised by 6 months. There is a statistically significant reduction in the contrast sensitivity, which was stabilised after 3 months. Only, 9.5% patients had peripheral constrictions of visual field and no significant change in the colour vision. CONCLUSION We recommend panretinal photocoagulation for all patients with proliferative diabetic retinopathy.

Twentieth-Century Latin American Literary Studies and Cultural Autonomy

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Naomi Lindstrom

1995-06-01

Full Text Available Since the 1920s, when scholars first began to specialize in Latin American writing, the subject of Latin American literary studies has grown from a small subset of Spanish and Portuguese literary research and teaching to become the largest field within Hispanism and a significant presence in comparative literature. The expansion of their place in the academic world has often prompted students of Latin American literature to wonder whether, in being swept into the mainstream, their field has not left out of account the historical situations of Latin American nations. These reflections lead critics back to a problem that has troubled Latin American thinkers since Independence: the achievement, or erosion, of cultural autonomy. Though undeniably close to major powers, the Latin American nations are unequal partners in trade and cultural exchange. Corresponding to their uneven and shifting relations with Europe and later the United States, their cultural life evolves following a distinctive historical dynamic. This article considers recent efforts by scholars and essayists to characterize the features that distinguish Latin America from more politically and economically advantaged nations. Special attention goes to those scholars who, drawing on anthropological research, examine communicative and expressive practices of indigenous origin, and those who borrow from economic theory to view Latin America as shaped by its history of dependence on more powerful nations and regions.

STORY OF BIG FLOOD IN THE MODERN INDONESIAN LITERARY: AN ECOCRITICISM STUDY

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Saifur Rohman

2015-06-01

Full Text Available The nature of paper shows that Ecocriticism is not popular issue in the modern Indonesian criticism. Hence, it is very crucial to develop the Indonesian criticism based on the ecological perspective because nowday that the term development is synonym with exploiting the nature. The paper is to find out the ecological issue in the modern indonesian literary, especially in fiction prose and poems publised for late ten years. To analyze the work, researcher is used semiotic method and hermeneutic design of research as an approach. Semiotic will investigate the symbol behind the words and hermeneutic will translated the symbol to actual message. Based on the analysis, the ecological theme in the modern Indonesian literary is crucial interpretation. The meaning appeared in the work  has given the imporant values of increasing care of nature, human kind, and harmonization. For recomentation, in the future researcher should have interpretate the work based on the ecocriticism to increase meaning of human and nature.

On the Origin of Hobbes’s Conception of Language: The Literary Culture of English Renaissance Humanism

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Sergio H. Orozco-Echeverri

2012-12-01

Full Text Available Hobbes' education in the literary culture of English Renaissance humanism has been overlooked as an important tradition in understanding his position in Early Modern Philosophy. Against the traditional readings of Hobbes' conception of language as a sequel to Medieval nominalism, I will argue that Hobbes' education in the literary culture of Renaissance humanism and his subsequent developments in this tradition would have allowed him to consider philosophical problems raised by new science in an original way and, thus, to introduce his innovative conception of language as the core of his solution to the problem of social and natural orders.

Evaluation of the effects of ethinylestradiol on sexual differentiation in the olvas-GFP/STII-YI medaka (transgenic Oryzias latipes) strain as estimated by proliferative activity of germ cells

International Nuclear Information System (INIS)

Hano, Takeshi; Oshima, Yuji; Kinoshita, Masato; Tanaka, Minoru; Mishima, Noriko; Wakamatsu, Yuko; Ozato, Kenjiro; Shimasaki, Yohei; Honjo, Tsuneo

2011-01-01

We evaluated the effects of 17(-ethinylestradiol (EE 2 ) on sexual differentiation in transgenic olvas-GFP/STII-YI medaka (Oryzias latipes) in terms of the proliferative activity of germ cells. This strain contains the green fluorescent protein (GFP) gene fused to the regulatory region of the medaka vasa gene, and germ cell-specific expression of GFP can be visualized in living (transparent) individuals. From 0 days post-hatch (0 dph) onwards, juveniles were exposed to graded concentrations of EE 2 (25.2-1710 ng/L) for 35 days. The gonads of live specimens were monitored by measuring their size and calculating their GFP-fluorescence area. GFP-fluorescent area in control females was about 10 times that in control males at 10 days posthatch (dph) whereas the gonadal size of 10 dph males that had been exposed to 158 ng/L of EE 2 significantly increased up to twice the size of control males, indicating that abnormal sexual differentiation towards female might occur in these individuals. Histological examination and identification of the sex-linked marker SL1 indicated that male to female sex reversal occurred at EE 2 exposure ≥45.1 ng/L at 35 dph. These results suggest that observation of proliferative activity of germ cells in the olvas-GFP/STII-YI strain could be applied to facilitated screening fish model to detect adverse effects on sexual differentiation as early as 10 dph juveniles.

The Getic Ovid in Prešeren and Politian: Literary Myth, Political Paradigm, Civilisatory Argument

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Marko Marinčič

2010-12-01

Full Text Available For France Prešeren, Ovid is an important literary model (Gazele[Ghazals], Ljubeznjeni soneti[Amorous Sonnets] and the paradigm of an unhappy poet (Glosa. In fact, what has prompted some contemporary interpreters to read Ovid’s exile to Tomis as mere autobiographical fiction is Ovid’s own endeavour to endow his exile with a paradigmatic quality. The experience of the poet-exile, described in the Tristia andEpistulae ex Ponto, thus acquired the status of a literary myth in the early modern era; it was already Angelo Poliziano who additionally used it as a paradigm of great literary authority, which could be wielded by a contemporary poet-exile as an argument in his conflict with the prince or the state. Politian, who voluntarily withdrew from Florence for six months in 1479–80, applied Ovid’s exile in literary form to his own experience; his Epigram XXVII sounds the theme of his decline as an artist, which the prince may halt by recalling the poet from the barbarian country. Ovid himself attributed his artistic “decline” to his linguistic alienation, practically illustrating the latter with subtle stylistic devices (such as “stuttering”. Similarly, Prešeren’s German cycle, which was published in the Illyrisches Blatt and originally intended for publication in his Poems, may be read as a didactic staging of denationalisation; the first poem, which expressly alludes to Ovid, effectively portrays by reference to the Tristia the spontaneous, uncontrolled process of language assimilation. In this sense, the German cycle is both a warning, aimed at the half-Germanised bourgeoisie, and a self-ironic, metaliterary illustration of linguistic alienation in the poet’s home exile.

Analysis of the proliferative potential of odontogenic epithelial cells of pericoronal follicles.

Science.gov (United States)

Cimadon, Natalia; Lauxen, Isabel Silva; Carrard, Vinicius Coelho; Sant'Ana Filho, Manoel; Rados, Pantelis Varvaki; Oliveira, Márcia Gaiger

2014-11-01

To evaluate the proliferative potential and the cell proliferation rate of odontogenic epithelial cells. Forty-two cases of pericoronal follicles of impacted third molars were submitted to silver impregnation technique for quantification of argyrophilic nucleolar organizer regions (AgNOR) and immunohistochemical staining for EGFR and Ki-67. For AgNOR quantification, the mean number of active nucleolar organizer regions per nucleus (mAgNOR) and the percentage of cells with 1, 2, 3 and 4 or more AgNORs per nucleus (pAgNOR) were quantified. Ki-67 immunolabeling was quantified, whereas for EGFR, a descriptive analysis of staining patterns (membrane, cytoplasm or membrane + cytoplasm positivity) was performed. We evaluated the reduced epithelium of the enamel organ and/or islands of odontogenic epithelium present in the entire connective tissue. mAgNOR were 1.43 (1.0-2.42) and were significantly different among pericoronary follicles from upper and lower teeth (p = 0.041). Immunostaining of Ki-67 was negative in all cases. EGFR immunolabeling was found mainly in the cytoplasm and was more intense in islands and cords when compared to reduced epithelium of the enamel organ. Odontogenic epithelial cells of some pericoronal follicles have proliferative potential, suggesting their association with the development of odontogenic lesions. The authors suggest that nonerupted, especially of the lower teeth, should be monitored and if necessary removed.

Role of Stromal Paracrine Signals in Proliferative Diseases of the Aging Human Prostate

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Kenichiro Ishii

2018-04-01

Full Text Available Androgens are essential for the development, differentiation, growth, and function of the prostate through epithelial–stromal interactions. However, androgen concentrations in the hypertrophic human prostate decrease significantly with age, suggesting an inverse correlation between androgen levels and proliferative diseases of the aging prostate. In elderly males, age- and/or androgen-related stromal remodeling is spontaneously induced, i.e., increased fibroblast and myofibroblast numbers, but decreased smooth muscle cell numbers in the prostatic stroma. These fibroblasts produce not only growth factors, cytokines, and extracellular matrix proteins, but also microRNAs as stromal paracrine signals that stimulate prostate epithelial cell proliferation. Surgical or chemical castration is the standard systemic therapy for patients with advanced prostate cancer. Androgen deprivation therapy induces temporary remission, but the majority of patients eventually progress to castration-resistant prostate cancer, which is associated with a high mortality rate. Androgen deprivation therapy-induced stromal remodeling may be involved in the development and progression of castration-resistant prostate cancer. In the tumor microenvironment, activated fibroblasts stimulating prostate cancer cell proliferation are called carcinoma-associated fibroblasts. In this review, we summarize the role of stromal paracrine signals in proliferative diseases of the aging human prostate and discuss the potential clinical applications of carcinoma-associated fibroblast-derived exosomal microRNAs as promising biomarkers.

Scoring radiologic characteristics to predict proliferative potential in meningiomas

International Nuclear Information System (INIS)

Hashiba, Tetsuo; Hashimoto, Naoya; Maruno, Motohiko; Izumoto, Shuichi; Suzuki, Tsuyoshi; Kagawa, Naoki; Yoshimine, Toshiki

2006-01-01

We investigated the feasibility of using radiologic characteristics to predict the proliferative potential in meningiomas. Our statistical analysis revealed that the presence of peritumoral edema, an ambiguous brain-tumor border, and irregular tumor shape were significantly correlated with a higher MIB-1 staining index (SI) value. We developed the following scoring system for specific features in each tumor: peritumoral edema (tumor with edema=1, tumor without edema=0); brain-tumor border (tumor with any ambiguous border=1, tumor circumscribed by a distinct rim=0); and tumor shape (tumor with irregular shape=1, tumor with smooth shape=0). Using Spearman's correlation coefficient analysis, we found a significant correlation (P<0.005) between total score calculated for each patient and SI value. Our findings suggest that the proliferative potential of meningiomas can be predicted using a less invasive preoperative examination focusing on the presence of peritumoral edema, ambiguous brain-tumor border, and irregular tumor shape. (author)

Discourse on Narrative Research: The Construction Zone--Literary Elements in Narrative Research

Science.gov (United States)

Coulter, Cathy A.; Smith, Mary Lee

2009-01-01

Narrative research has become part of the landscape of education inquiry, yet its theory and practice are still debated and evolving. This article addresses the construction of narratives using literary elements common to nonfiction and fiction writings. The authors discuss these elements and use four narratives to illustrate them. They address…

It's Not the Book, It's Not the Author, It's the Award: The Lambda Literary Award and the Case for Strategic Essentialism

Science.gov (United States)

Crisp, Thomas

2011-01-01

On September 16, 2009, the Lambda Literary Foundation (LLF) released a statement revising their eligibility guidelines for the Lambda Literary Award, the most prestigious citation offered for LGBT books and authors. This criteria, which demands that an author must self-identify as a member of the LGBT family of writers, has been met with…

Literatura a digitální kultura: Potřebujeme digital literary studies?

Czech Academy of Sciences Publication Activity Database

Piorecký, Karel

2015-01-01

Roč. 63, č. 6 (2015), s. 935-949 ISSN 0009-0468 R&D Projects: GA ČR GPP406/12/P603 Institutional support: RVO:68378068 Keywords : digital culture * postdigital culture * literary system * digital humanities Subject RIV: AJ - Letters, Mass-media, Audiovision

Clinical empathy and narrative competence: the relevance of reading talmudic legends as literary fiction.

Science.gov (United States)

Davidson, John H

2015-04-01

The "curative potential" in almost any clinical setting depends on a caregiver establishing and maintaining an empathic connection with patients so as to achieve "narrative competence" in discerning and acting in accord with their preferences and best interests. The "narrative medicine" model of shared "close reading of literature and reflective writing" among clinicians as a means of fostering a capacity for clinical empathy has gained validation with recent empirical studies demonstrating the enhancement of theory of mind (ToM), broadly conceived as empathy, in readers of literary fiction. Talmudic legends, like that of Rabbi Judah's death, are under-appreciated, relevant sources of literary fiction for these efforts. The limitations of narrative medicine are readily counterbalanced by simultaneously practiced attention to traditional bioethical principles, including-especially-beneficence, non-maleficence, and autonomy.

Anti-proliferative effect of Moringa oleifera Lam (Moringaceae) leaf ...

African Journals Online (AJOL)

Purpose: To investigate the in vitro anti-proliferative effect and mechanism of action of Moringa oleifera Lam. leaf extract on human colon carcinoma HCT116 cell line. Methods: M. oleifera leaves were extracted with methanol. It was fractionated by Sephadex LH-20 column chromatography. Several fractions were identified ...

What Renaissance Literary Theory Tells us about Climate Communication

Science.gov (United States)

Guenther, G. J.

2017-12-01

Many current debates in climate communication-to convey the consensus or not to convey the consensus; to frighten people or encourage them-seem to center on the question of how to discuss climate science and its ability to predict climate impacts. By examining the Renaissance literary theory that represents poets as better teachers than philosophers and scientists, this paper argues that climate advocates should redefine climate communication to include a variety of artistic discourses that make meaning in order to inspire people into political action.

On variation of word frequencies in Russian literary texts

Science.gov (United States)

Kargin, Vladislav

2016-03-01

We study the variation of word frequencies in Russian literary texts. Our findings indicate that the standard deviation of a word's frequency across texts depends on its average frequency according to a power law with exponent 1/2 volatility (that is, higher "burstiness"). A latent factor model has been estimated to investigate the structure of the word frequency distribution. The findings suggest that the dependence of a word's frequency volatility on its average frequency can be explained by the asymmetry in the distribution of latent factors.

Body linear traits for identifying prolific goats

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Avijit Haldar

2014-12-01

Full Text Available Aim: The present study was conducted on prolific goat breed to identify body linear type traits that might be associated with prolificacy trait in goats. Materials and Methods: Two-stage stratified random sample survey based data were collected from 1427 non-pregnant goats with the history of single, twin and triplet litter sizes (LZ between January 2008 to February 2011 for 3 years in 68 villages located in East and North East India. Data on sixteen body linear traits were analyzed using logistic regression model to do the step-wise selection for identifying the body linear traits that could determine LZ. An average value for each identified body linear trait was determined for classifying the goats into three categories: Goats having the history of single LZ, goats having the history of twin LZ and goats having the history of triplet LZ. Results: The LZ proportions for single, twin and triplet, were 29.50, 59.14 and 11.36%, respectively, with the prolificacy rate of 181.85% in Indian Black Bengal goats. A total of eight body linear traits that could determine LZ in prolific goats were identified. Heart girth (HG measurement (>60.90 cm, paunch girth (PG (>70.22 cm, wither height (WH (>49.75 cm, neck length (>21.45 cm, ear length (>12.80 cm and distance between trochanter major (DTM bones (>12.28 cm, pelvic triangle area (PTA (>572.25 cm2 and clearance at udder (CU (>23.16 cm showed an increase likelihood of multiple LZ when compared to single LZ. Further, HG measurement (>62.29 cm, WH (>50.54 cm, PG (>71.85 cm and ear length (>13.00 cm, neck length (>22.01 cm, PTA (>589.64 cm2, CU (>23.20 cm and DTM bones (>12.47 cm were associated with increased likelihood of triplet LZ, when compared with that of twin LZ. Conclusion: HG measurement was the best discriminating factor, while PG, neck length, DTM bones, CU, PTA, WH and ear length measurements were other important factors that could be used for identifying prolific goats to achieve economic

Proliferative Retinopathy in Type 1 Diabetes Is Associated With Cerebral Microbleeds, Which Is Part of Generalized Microangiopathy

NARCIS (Netherlands)

Woerdeman, J.P.; van Duinkerken, E.; Wattjes, M.P.; Barkhof, F.; Snoek, F.J.; Moll, A.C.; Klein, M.; de Boer, M.P.; IJzerman, R.G.; Serne, E.H.; Diamant, M.

2014-01-01

OBJECTIVE: We investigated whether proliferative diabetic retinopathy in type 1 diabetic patients can be generalized to cerebral small vessel disease and whether it is associated with impaired peripheral microvascular function. RESEARCH DESIGN AND METHODS: Thirty-three patients with proliferative

The literary myth of the double in entertainment media content

OpenAIRE

Robson Souza dos Santos

2011-01-01

This article discusses how the myth of the literary double stands in entertainment media, becoming a recurrent figure of cinema productions, and, later on, of soap operas, the main entertainment vehicle in latin-american countries. Frequently, the image of the double or stunt-man, in literature and soap opera productions, has been directly associated with the creature’s desire of becoming creator, and that myth is the main focus of discussion in this article.

A synthetic cryptochrome inhibitor induces anti-proliferative effects and increases chemosensitivity in human breast cancer cells

Energy Technology Data Exchange (ETDEWEB)

Chun, Sung Kook [Department of Brain & Cognitive Sciences, Daegu-Gyeongbuk Institute of Science & Technology, Daegu, 711-873 (Korea, Republic of); Department of Biological Sciences, Seoul National University, Seoul, 151-747 (Korea, Republic of); Department of Brain & Cognitive Sciences, Seoul National University, Seoul, 151-747 (Korea, Republic of); Chung, Sooyoung [Department of Biological Sciences, Seoul National University, Seoul, 151-747 (Korea, Republic of); Department of Biomedical Sciences, College of Medicine, Korea University, Seoul, 136-705 (Korea, Republic of); Kim, Hee-Dae [Department of Biological Sciences, Seoul National University, Seoul, 151-747 (Korea, Republic of); Lee, Ju Hyung [Department of Systems Biology, Yonsei University College of Life Science and Biotechnology, Seoul 120-749 (Korea, Republic of); Jang, Jaebong [College of Pharmacy, Seoul National University, Seoul, 151-742 (Korea, Republic of); Kim, Jeongah; Kim, Doyeon [Department of Brain & Cognitive Sciences, Daegu-Gyeongbuk Institute of Science & Technology, Daegu, 711-873 (Korea, Republic of); Department of Biological Sciences, Seoul National University, Seoul, 151-747 (Korea, Republic of); Department of Brain & Cognitive Sciences, Seoul National University, Seoul, 151-747 (Korea, Republic of); Son, Gi Hoon [Department of Biomedical Sciences, College of Medicine, Korea University, Seoul, 136-705 (Korea, Republic of); Oh, Young J. [Department of Systems Biology, Yonsei University College of Life Science and Biotechnology, Seoul 120-749 (Korea, Republic of); Suh, Young-Ger [College of Pharmacy, Seoul National University, Seoul, 151-742 (Korea, Republic of); Lee, Cheol Soon [Gachon Clinical Trials Center, Gachon University, Incheon, 417-842 (Korea, Republic of); and others

2015-11-13

Disruption of circadian rhythm is a major cause of breast cancer in humans. Cryptochrome (CRY), a circadian transcription factor, is a risk factor for initiation of breast cancer, and it is differentially expressed between normal and breast cancer tissues. Here, we evaluated the anti-proliferative and pro-apoptotic activity of KS15, a recently discovered small-molecule inhibitor of CRY, in human breast cancer cells. First, we investigated whether KS15 treatment could promote E-box-mediated transcription by inhibiting the activity of CRY in MCF-7 human breast cancer cells. Protein and mRNA levels of regulators of cell cycle and apoptosis, as well as core clock genes, were differentially modulated in response to KS15. Next, we investigated whether KS15 could inhibit proliferation and increase sensitivity to anti-tumor drugs in MCF-7 cells. We found that KS15 decreased the speed of cell growth and increased the chemosensitivity of MCF-7 cells to doxorubicin and tamoxifen, but had no effect on MCF-10A cells. These findings suggested that pharmacological inhibition of CRY by KS15 exerts an anti-proliferative effect and increases sensitivity to anti-tumor drugs in a specific type of breast cancer. - Highlights: • Cryptochrome inhibitor (KS15) has anti-tumor activity to human breast cancer cells. • KS15 induces differential changes in cell cycle regulators and pro-apoptotic genes. • KS15 inhibits MCF-7 cell growth and enhances susceptibility to anti-tumor drugs.

A synthetic cryptochrome inhibitor induces anti-proliferative effects and increases chemosensitivity in human breast cancer cells

International Nuclear Information System (INIS)

Chun, Sung Kook; Chung, Sooyoung; Kim, Hee-Dae; Lee, Ju Hyung; Jang, Jaebong; Kim, Jeongah; Kim, Doyeon; Son, Gi Hoon; Oh, Young J.; Suh, Young-Ger; Lee, Cheol Soon

2015-01-01

Disruption of circadian rhythm is a major cause of breast cancer in humans. Cryptochrome (CRY), a circadian transcription factor, is a risk factor for initiation of breast cancer, and it is differentially expressed between normal and breast cancer tissues. Here, we evaluated the anti-proliferative and pro-apoptotic activity of KS15, a recently discovered small-molecule inhibitor of CRY, in human breast cancer cells. First, we investigated whether KS15 treatment could promote E-box-mediated transcription by inhibiting the activity of CRY in MCF-7 human breast cancer cells. Protein and mRNA levels of regulators of cell cycle and apoptosis, as well as core clock genes, were differentially modulated in response to KS15. Next, we investigated whether KS15 could inhibit proliferation and increase sensitivity to anti-tumor drugs in MCF-7 cells. We found that KS15 decreased the speed of cell growth and increased the chemosensitivity of MCF-7 cells to doxorubicin and tamoxifen, but had no effect on MCF-10A cells. These findings suggested that pharmacological inhibition of CRY by KS15 exerts an anti-proliferative effect and increases sensitivity to anti-tumor drugs in a specific type of breast cancer. - Highlights: • Cryptochrome inhibitor (KS15) has anti-tumor activity to human breast cancer cells. • KS15 induces differential changes in cell cycle regulators and pro-apoptotic genes. • KS15 inhibits MCF-7 cell growth and enhances susceptibility to anti-tumor drugs.

LANGUAGE USED IN ADVERTISING LITERARY ARTS REKLAM DİLİNDE KULLANILAN EDEBÎ SANATLAR

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Bekir ÇINAR

2009-12-01

Full Text Available This study, has been prepeared for examining the advertisement texts creativities and artistic language particularities especially for literary arts. For this reason spoken, written and visual media advertisements has been used. Which media groups will publish this sample advertise ments has been confirmed. The literary arts published in the advertisements have been defined shortly then with this work how much literary arts has been used in the advertisement will be shown you. Bu çalışma, reklam metinlerinin yaratıcı ve sanatsal bir dil özelliğini edebî sanatlar bağlamında incelemek amacıyla hazırlanmıştır. Bu amaçla sözlü, yazılı ve görsel medyadaki reklamlardan ve bazı haber başlıklarından faydalanılmıştır. Örneklemeye alınan reklamların hangi basın yayın organında yayınlandığı belirtilmiştir. Reklamlarda yer alan edebî sanatların önce kısa bir tanımı yapılmış, daha sonra reklamla ilişkilendirerek açıklanmıştır. Bu çalışmayla reklam dilinde edebî sanatların ne ölçüde kullanıldığı gösterilmeye çalışılacaktır.

Should the Bible Be Taught as a Literary Classic in Public Education?

Science.gov (United States)

Malikow, Max

2010-01-01

The research question "Should the Bible be taught as a literary classic in public education?" was pursued by a survey of nineteen scholars from three disciplines: education, literature, and law. The collected data served to guide the researcher in the writing of an analytical essay responding to the research question. The research…

Readings on Ernest Hemingway. The Greenhaven Press Literary Companion to American Authors.

Science.gov (United States)

de Koster, Katie, Ed.

Intended as an accessible resource for students researching America's greatest literary figures, this collection of essays about Ernest Hemingway's (1899-1961) work contains an in-depth biography and essays taken from a wide variety of sources. The essays are edited to accommodate the reading and comprehension levels of young adults; each essay is…

THE IMAGE OF THE POET MIHAI EMINESCU IN THE LITERARY DICTIONARIES

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Petra Denisa Tcacenco

2015-12-01

Full Text Available Mihai Eminescu is known as the Romanian national poet, the most important writer of the XIXͭʰ century in Romanian literature, whose writings have been intensely interpreted since his poetic debut. Therefore, this paper proposes a study of the way the literary dictionaries build the image of “the national poet”. This identity construct is significant to our investigation because it influences the interpretation of the poet figure through history. In order to have a wider view of the problem, we consulted a series of literary dictionaries and, also, dictionaries for students use to see how the figure of Eminescu is taught in schools. Moreover, we did not put aside foreign dictionaries, which bring a more objective perspective to the issue. The majority of Romanian dictionaries alter the poet’s portrait in favor of a “national construct”, created partly by the use of rhetoric figures. Another way of composing him a deformed image is accomplished by writing subjective and opaque interpretation of his poems. Consequently, such hermeneutics focuses on developing a myth that reflects mainly the way Romanians as nation want to be recognized and remembered.

Three Literary Works, Three Countries, Three Dimensions of Modernity

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Yücel KARADAŞ

2010-12-01

Full Text Available This article studies three literary works—two dramatic works and a novel—in terms of the modernization processes in three countries, of the class relationships to which these processes gave rise, the classes lost or gained power and of the character types arisen in these processes. These three countries are Turkey, Russia and England. And the three literary works are Yakup Kadri Karaosmanoglu‘s Kiralik Konak from Turkish literature, Chekhov‘s The Cherry Orchard from Russian literature and Bernard Shaw‘s Heartbreak House from English literature. During the selection of the first two works the facts that the modernization processes in Turkey and Russia began around the same time and that there were certain wars and different kinds of relationship between the two countries in the last two centuries of the Ottoman Empire were taken into consideration. Moving from this point, we aim to compare and contrast the Turkish-Ottoman modernization with the modernization process in Russia. On the other hand, the reason behind the selection of Heartbreak House is that it is thought that a comparison or a contrast with an industrialized country—England—that completed its modernization in the 19th and the beginning of the 20th centuries would facilitate understanding the different levels of modernization experienced in Turkey and Russia at the time. Thus, the article analyzes the abovementioned works from a sociological perspective to arrive at some conclusion about the modernization processes and socio-economical upheavals in three countries

Too much of a good thing? An observational study of prolific authors.

Science.gov (United States)

Wager, Elizabeth; Singhvi, Sanjay; Kleinert, Sabine

2015-01-01

Introduction. Researchers' productivity is usually measured in terms of their publication output. A minimum number of publications is required for some medical qualifications and professional appointments. However, authoring an unfeasibly large number of publications might indicate disregard of authorship criteria or even fraud. We therefore examined publication patterns of highly prolific authors in 4 medical specialties. Methods. We analysed Medline publications from 2008-12 using bespoke software to disambiguate individual authors focusing on 4 discrete topics (to further reduce the risk of combining publications from authors with the same name and affiliation). This enabled us to assess the number and type of publications per author per year. Results. While 99% of authors were listed on fewer than 20 publications in the 5-year period, 24 authors in the chosen areas were listed on at least 25 publications in a single year (i.e., >1 publication per 10 working days). Types of publication by the prolific authors varied but included substantial numbers of original research papers (not simply editorials or letters). Conclusions. Institutions and funders should be alert to unfeasibly prolific authors when measuring and creating incentives for researcher productivity.

Too much of a good thing? An observational study of prolific authors

Directory of Open Access Journals (Sweden)

Elizabeth Wager

2015-08-01

Full Text Available Introduction. Researchers’ productivity is usually measured in terms of their publication output. A minimum number of publications is required for some medical qualifications and professional appointments. However, authoring an unfeasibly large number of publications might indicate disregard of authorship criteria or even fraud. We therefore examined publication patterns of highly prolific authors in 4 medical specialties.Methods. We analysed Medline publications from 2008–12 using bespoke software to disambiguate individual authors focusing on 4 discrete topics (to further reduce the risk of combining publications from authors with the same name and affiliation. This enabled us to assess the number and type of publications per author per year.Results. While 99% of authors were listed on fewer than 20 publications in the 5-year period, 24 authors in the chosen areas were listed on at least 25 publications in a single year (i.e., >1 publication per 10 working days. Types of publication by the prolific authors varied but included substantial numbers of original research papers (not simply editorials or letters.Conclusions. Institutions and funders should be alert to unfeasibly prolific authors when measuring and creating incentives for researcher productivity.

Prolific plant regeneration through organogenesis from scalps of ...

African Journals Online (AJOL)

Four types of potting media comprising of sand, peat, sand + top soil + goat dung (3:2:1 v/v) and top soil + sand (1:1 v/v) were evaluated during acclimatization of the plantlets. Prolific shoot regeneration from scalps was obtained on MS medium containing 2.5 mM BAP, at 9.61 and 40.6 shoots per explant after 4 and 8 weeks ...

Russia's Literary Genius Alexander Pushkin: The Great-Grandson of an African Slave.

Science.gov (United States)

Lounsbery, Anne

2000-01-01

Alexander Pushkin, Russia's most celebrated literary figure, descended from an African slave. On both parents' sides, he was related to Avram Petrovich Gannibal, who was born to an African prince and abducted to become a slave to a Russian diplomat. Pushkin chose to pride himself on both his aristocratic life and his African ancestry. (SM)

Readings on Jane Austen. The Greenhaven Press Literary Companion to British Authors.

Science.gov (United States)

Swisher, Clarice, Ed.

Designed for young adults, this book on Jane Austen's novels is one of an anthology series providing accessible resources for students researching great literary lives and works. Contributing writers' essays in the book are taken from a wide variety of sources and are edited to accommodate the reading and comprehension levels of young adults; each…

Write it right a little blacklist of literary faults

CERN Document Server

Bierce, Ambrose

2010-01-01

Amusing and thought-provoking, this A-to-Z compendium outlines common oral and written gaffes. Ambrose Bierce, a celebrated literary wit, assembled his informative compilation in 1909 from many years of observations and notes. He advocates precision in language, offering alternatives to grammatical lapses and inaccurate word choices.Moneyed for Wealthy: ""The moneyed men of New York."" One might as sensibly say, ""The cattled men of Texas,"" or, ""The lobstered men of the fish market."" Name for Title and Name: ""His name was Mr. Smith."" Surely no babe was ever christened Mister. Juncture m

Current Practices in Instruction in the Literary Braille Code University Personnel Preparation Programs

Science.gov (United States)

Rosenblum, L. Penny; Lewis, Sandra; D'Andrea, Frances Mary

2010-01-01

University instructors were surveyed to determine the requirements for their literary braille courses. Twenty-one instructors provided information on the textbooks they used; how they determined errors; reading proficiency requirements; and other pertinent information, such as methods of assessing mastery of the production of braille using a…

Editing Identity: Literary Anthologies and the Construction of the Author in Meiji Japan

Science.gov (United States)

Des Jardin, Molly Catherine

2012-01-01

"Editing Identity: Literary Anthologies and the Construction of the Author in Meiji Japan" problematizes widespread acceptance of anthologies of authors' "complete works" as both transparent and authoritative compendia of Japanese literature. In the Meiji period (1868-1912), they enjoyed a sudden boom in popularity and have…

Proliferative myositis in a patient with AIDS

International Nuclear Information System (INIS)

Wlachovska, B.; Deux, J.F.; Marsault, C.; Le Breton, C.; Abraham, B.; Sibony, M.

2004-01-01

We report a case of proliferative myositis in the right biceps of a 56-year-old man with acquired immune deficiency syndrome (AIDS). Imaging methods included sonography, computed tomography and magnetic resonance imaging. The diagnosis was made by a core-cut biopsy and fine needle aspiration biopsy with immunohistochemical analysis. The lesion disappeared after 2 months without treatment. It is particularly important to determine whether intramuscular masses arising in patients with AIDS are due to an infectious or malignant process. (orig.)

Proliferative myositis in a patient with AIDS

Energy Technology Data Exchange (ETDEWEB)

Wlachovska, B.; Deux, J.F.; Marsault, C.; Le Breton, C. [Department of Radiology, Hopital Tenon, 4 rue de la Chine, 75020, Paris (France); Abraham, B. [Department of Tropical and Infectious Diseases, Hopital Tenon, Paris (France); Sibony, M. [Department of Anatomy, Hopital Tenon, Paris (France)

2004-04-01

We report a case of proliferative myositis in the right biceps of a 56-year-old man with acquired immune deficiency syndrome (AIDS). Imaging methods included sonography, computed tomography and magnetic resonance imaging. The diagnosis was made by a core-cut biopsy and fine needle aspiration biopsy with immunohistochemical analysis. The lesion disappeared after 2 months without treatment. It is particularly important to determine whether intramuscular masses arising in patients with AIDS are due to an infectious or malignant process. (orig.)

Anti-proliferative therapy for HIV cure: a compound interest approach.

Science.gov (United States)

Reeves, Daniel B; Duke, Elizabeth R; Hughes, Sean M; Prlic, Martin; Hladik, Florian; Schiffer, Joshua T

2017-06-21

In the era of antiretroviral therapy (ART), HIV-1 infection is no longer tantamount to early death. Yet the benefits of treatment are available only to those who can access, afford, and tolerate taking daily pills. True cure is challenged by HIV latency, the ability of chromosomally integrated virus to persist within memory CD4 + T cells in a non-replicative state and activate when ART is discontinued. Using a mathematical model of HIV dynamics, we demonstrate that treatment strategies offering modest but continual enhancement of reservoir clearance rates result in faster cure than abrupt, one-time reductions in reservoir size. We frame this concept in terms of compounding interest: small changes in interest rate drastically improve returns over time. On ART, latent cell proliferation rates are orders of magnitude larger than activation and new infection rates. Contingent on subtypes of cells that may make up the reservoir and their respective proliferation rates, our model predicts that coupling clinically available, anti-proliferative therapies with ART could result in functional cure within 2-10 years rather than several decades on ART alone.

Bloomsday 100: the making of a literary legend.

Science.gov (United States)

Kaplan, Robert M

2004-06-01

As a background to the centenary of Bloomsday, to explore the circumstances in which James Joyce wrote "Ulysses", noting the autobiographical elements and unique style, including the stream-of-consciousness technique that depicted the inner life of the characters. Selected quotations are used to illustrate these points. Joyce wanted to show that the epic and the heroic is in our lives every day. "Ulysses" defined the literary consciousness of the 20th century. By basing the novel about a day in the life of three ordinary characters on Homer's epic account of an 18 year voyage, Joyce re-established the link between 20th century consciousness and classical times.

Literary study and evolutionary theory : A review essay.

Science.gov (United States)

Carroll, J

1998-09-01

Several recent books have claimed to integrate literary study with evolutionary biology. All of the books here considered, except Robert Storey's, adopt conceptions of evolutionary theory that are in some way marginal to the Darwinian adaptationist program. All the works attempt to connect evolutionary study with various other disciplines or methodologies: for example, with cultural anthropology, cognitive psychology, the psychology of emotion, neurobiology, chaos theory, or structuralist linguistics. No empirical paradigm has yet been established for this field, but important steps have been taken, especially by Storey, in formulating basic principles, identifying appropriate disciplinary connections, and marking out lines of inquiry. Reciprocal efforts are needed from biologists and social scientists.

Clinical Empathy and Narrative Competence: The Relevance of Reading Talmudic Legends as Literary Fiction

Directory of Open Access Journals (Sweden)

John H. Davidson

2015-04-01

Full Text Available The “curative potential” in almost any clinical setting depends on a caregiver establishing and maintaining an empathic connection with patients so as to achieve “narrative competence” in discerning and acting in accord with their preferences and best interests. The “narrative medicine” model of shared “close reading of literature and reflective writing” among clinicians as a means of fostering a capacity for clinical empathy has gained validation with recent empirical studies demonstrating the enhancement of theory of mind (ToM, broadly conceived as empathy, in readers of literary fiction. Talmudic legends, like that of Rabbi Judah’s death, are under-appreciated, relevant sources of literary fiction for these efforts. The limitations of narrative medicine are readily counterbalanced by simultaneously practiced attention to traditional bioethical principles, including—especially—beneficence, non-maleficence, and autonomy.

The Literary Essay as Encomium in Virginia Woolf’s “The Enchanted Organ”

Directory of Open Access Journals (Sweden)

Margarita Esther Sánchez Cuervo

2014-09-01

Full Text Available This article proposes a rhetorical analysis of “The Enchanted Organ”, a short essay by Virginia Woolf that reviews Anne Thackeray’s collection of letters that was published after her death. In this review, Woolf portrays Anne Thackeray’s character starting from extracts from the diary and letters that she wrote as part of her literary production. The argumentative nature of this essay can be studied by means of a rhetorical analysis that examines the operations of inventio, dispositio and elocutio. The account of arguments and rhetorical figures that appears after the analysis of these operations results in an interpretation of presence that draws Anne Thackeray as a gentle figure that was content with simple things and that “was dancing to the music” of her writing. As a result, “The Enchanted Organ” can be read as an encomium that praises Thackeray’s cheerful personality rather than her literary merits.

Azithromycin Synergistically Enhances Anti-Proliferative Activity of Vincristine in Cervical and Gastric Cancer Cells

International Nuclear Information System (INIS)

Zhou, Xuezhang; Zhang, Yuyan; Li, Yong; Hao, Xiujing; Liu, Xiaoming; Wang, Yujiong

2012-01-01

In this study, the anti-proliferative and anticancer activity of azithromycin (AZM) was examined. In the presence of AZM, cell growth was inhibited more effectively in Hela and SGC-7901 cancer cells, relative to transformed BHK-21 cells. The respective 50% inhibition of cell growth (IC 50 ) values for Hela, SGC-7901 and BHK-21 were 15.66, 26.05 and 91.00 µg/mL at 72 h post incubation, indicative of a selective cytotoxicity against cancer cells. Cell apoptosis analysis using Hoechst nuclear staining and annexin V-FITC binding assay further demonstrated that AZM was capable of inducing apoptosis in both cancer cells and transformed cells. The apoptosis induced by AZM was partly through a caspase-dependent mechanism with an up-regulation of apoptotic protein cleavage PARP and caspase-3 products, as well as a down-regulation of anti-apoptotic proteins, Mcl-1, bcl-2 and bcl-X1. More importantly, a combination of AZM and a low dose of the common anti-cancer chemotherapeutic agent vincristine (VCR), produced a selectively synergistic effect on apoptosis of Hela and SGC-7901 cells, but not BHK-21 cells. In the presence of 12.50 μg/mL of VCR, the respective IC 50 values of Hela, SGC-7901 and BHK-21 cells to AZM were reduced to 9.47 µg/mL, 8.43 µg/mL and 40.15 µg/mL at 72 h after the incubation, suggesting that the cytotoxicity of AZM had a selective anti-cancer effect on cancer over transformed cells in vitro. These results imply that AZM may be a potential anticancer agent for use in chemotherapy regimens, and it may minimize side effects via reduction of dosage and enhancing the effectiveness common chemotherapeutic drugs

Dutch guidelines for diagnosis and therapy of proliferative lupus nephritis

NARCIS (Netherlands)

van Tellingen, A.; Voskuyl, A. E.; Vervloet, M. G.; Bijl, M.; de Sevaux, R. G. L.; Berger, S. P.; Derksen, R. H. W. M.; Berden, J. H. M.

Proliferative lupus nephritis is a strong predictor of morbidity and mortality in patients with systemic lupus erythematosus. Despite improvements in the management of lupus nephritis, a significant number of the patients do not respond to immunosuppressive therapy and progress to end-stage renal

An Epistemological Justification of the Place of Literary Art in the Curriculum.

Science.gov (United States)

Phillips, Ruth Ann

The purpose of this study was to epistemologically justify the place of literary art in the curriculum by showing that its aesthetic significance gives knowledge that can be communicated in no other terms than its own and that this knowledge is consistent with certain epistemological theories. Using theories of art proposed by Langer and Cassirer,…

Role of P-glycoprotein on CD69+CD4+ cells in the pathogenesis of proliferative lupus nephritis and non-responsiveness to immunosuppressive therapy.

Science.gov (United States)

Tsujimura, Shizuyo; Adachi, Tomoko; Saito, Kazuyoshi; Tanaka, Yoshiya

2017-01-01

P-glycoprotein (P-gp) expression on activated lymphocytes in systemic lupus erythematosus (SLE) plays a role in active efflux of intracellular drugs, resulting in drug resistance. The role of P-gp-expressing lymphocytes in the pathogenesis of SLE remains unclear. The aim of this study was to determine the importance of P-gp + CD4 + cells in organ manifestations in refractory SLE. The proportion of P-gp + CD4 + cells was determined by flow cytometry in peripheral blood of patients with SLE (n=116) and healthy adults (n=10). Renal biopsy specimens were examined by immunohistochemistry for P-gp expression. CD69 is a marker of CD4 cell activation. The proportion of both P-gp-expressing CD4 + cells and CD69-expressing CD4 + cells in peripheral blood was higher in SLE than control. The proportion of P-gp + CD69 + CD4 + cells correlated with Systemic Lupus Erythematosus Disease Activity Index and was higher in poor responders to corticosteroids. Furthermore, the proportion of P-gp + CD69 + CD4 + cells was significantly higher in proliferative lupus nephritis (LN) with poor response to corticosteroids. The efficacy of immunosuppressive therapy depended on the regulation of the proportion of P-gp + CD69 + CD4 + cells. Marked accumulation of P-gp + CD4 + cells in renal interstitial tissue and high proportion of peripheral P-gp + CD69 + CD4 + cells were noted in patients with proliferative LN. The results showed high proportion of P-gp + CD69 + CD4 + cells in peripheral blood and their accumulation in renal tissue in patients with proliferative LN refractory to CS therapy, suggesting that P-gp expression on activated CD4 + T cells is a potentially useful marker for refractoriness to treatment and a novel target for treatment.

Malignant Trigeminal Nerve Sheath Tumor and Anaplastic Astrocytoma Collision Tumor with High Proliferative Activity and Tumor Suppressor P53 Expression

Directory of Open Access Journals (Sweden)

Maher Kurdi

2014-01-01

Full Text Available Background. The synchronous development of two primary brain tumors of distinct cell of origin in close proximity or in contact with each other is extremely rare. We present the first case of collision tumor with two histological distinct tumors. Case Presentation. A 54-year-old woman presented with progressive atypical left facial pain and numbness for 8 months. MRI of the brain showed left middle cranial fossa heterogeneous mass extending into the infratemporal fossa. At surgery, a distinct but intermingled intra- and extradural tumor was demonstrated which was completely removed through left orbitozygomatic-temporal craniotomy. Histopathological examination showed that the tumor had two distinct components: malignant nerve sheath tumor of the trigeminal nerve and temporal lobe anaplastic astrocytoma. Proliferative activity and expressed tumor protein 53 (TP53 gene mutations were demonstrated in both tumors. Conclusions. We describe the first case of malignant trigeminal nerve sheath tumor (MTNST and anaplastic astrocytoma in collision and discuss the possible hypothesis of this rare occurrence. We propose that MTNST, with TP53 mutation, have participated in the formation of anaplastic astrocytoma, or vice versa.

Proliferative and nonproliferative breast disease in atomic-bomb survivors

International Nuclear Information System (INIS)

Tokunaga, Masayoshi; Land, C.E.; Aoki, Yoichiro; Yamamoto, Tsutomu; Asano, Masahide; Sato, Eiichi; Tokuoka, Shoji; Sakamoto, Goi; Page, D.L.

1993-10-01

The risk of female breast cancer in association with radiation exposure is well established, on the basis of follow-up studies of the atomic-bomb survivors and other exposed populations. This association is especially strong for women exposed before age 20 yr and appears to be much weaker among women exposed after age 40 yr. In this study, breast-tissue autopsy samples from high-dose and low-dose individuals in the Radiation Effects Research Foundation Life Span Study sample were examined in detail to determine whether nonproliferative or proliferative breast lesions are associated with radiation exposure. The results suggest that proliferative disease in general and atypical hyperplasia in particular are associated with radiation exposure and that the risk is strongest for subjects who were ages 40-49 yr at the time of the bombings. It is hypothesized that this finding may be related to the age dependence of radiation-induced breast cancer, in the sense that potential cancers reflecting early-stage changes induced at these ages by radiation exposure may receive too little hormonal promotion to progress to frank cancers. (author)

Fictions of the Writer: A Critical Articulation of Collaborative Writing and Literary Studies.

Science.gov (United States)

Haefner, Joel

In recent years the High Romantic concept of the solitary author has been intensely challenged. Compositionists and various theorists have deconstructed the concept of isolated authorship and critiqued the Romantic notion of individual genius. Meanwhile, the reconstruction of the female literary tradition introduced the question of gender and…

The Interdisciplinary Curriculum: A Literary Review and a Manual for Administrators and Teachers.

Science.gov (United States)

Smith, Jaimie; Karr-Kidwell, PJ

The purpose of this paper was to provide a literary review and to create a manual explaining the difference between an interdisciplinary curriculum and other curriculum approaches. An interdisciplinary curriculum is a holistic approach that links the disciplines by emphasizing relationships and connections. A different approach to curriculum…

Primo Levi and the Periodic Table: Teaching Chemistry Using A Literary Text (Excerpt)

Science.gov (United States)

Osorio, Viktoria Klara Lakatos; Tiedemann, Peter Wilhelm; Porto, Paulo Alves

2007-01-01

The excerpts from The Periodic Table book written by Primo Levi is discussed related to chemical concepts. The use of a literary text as a starting point of discussions of chemical concepts has allowed the integration of various topics covered in separate courses of the undergraduate program in chemistry.

Chemical Constituents from Cimicifuga dahurica and Their Anti-Proliferative Effects on MCF-7 Breast Cancer Cells.

Science.gov (United States)

Huyen, Chu Thi Thanh; Luyen, Bui Thi Thuy; Khan, Ghulam Jilany; Oanh, Ha Van; Hung, Ta Manh; Li, Hui-Jun; Li, Ping

2018-05-04

This study was designed to search for novel anti-cancer compounds from natural plants. The 70% ethanolic extract from the rizhomes of Cimicifuga dahurica (Turcz.) Maxim. (Ranunculaceae) was found to possess significant in vitro anti-proliferative effects on MCF-7 breast cancer cells. A phytochemical investigation using assay-guided fractionation of the ethanolic extract of C. dahurica resulted in the isolation of one new phenolic amide glycoside 3 , two new lignan glycosides 4 and 7 , one new 9,19-cycloartane triterpenoid glycoside 6 , and thirteen known constituents 1 , 2 , 5 , and 8 ⁻ 17 . The structures of 3 , 4 , 6 , and 7 were established using contemporary NMR methods and from their HRESIMS data. The anti-proliferative effects of isolated compounds were evaluated using the BrdU-proliferation kit. Five among the 17 isolated compounds showed significant anti-proliferative effects ( p ≤ 0.05), wherein compound 7 showed the most significant anti-proliferative and cell cycle arresting effect ( p ≤ 0.05) which followed a dose dependent manner. Western blot protein expression analysis showed a down expression of c-Myc and cyclin D1 which further elucidated the anti-proliferation mechanism of compound 7 while apoptotic effects were found in association with Bcl-2 family protein expression variations. Conclusively this study reports the isolation and identification of 17 compounds from C. dahurica , including four novel molecules, in addition to the fact that compound 7 possesses significant anti-proliferative and apoptotic effects in vitro that may require further exploration.

“There’s never any ending to Paris” Creating a Literary Myth: Geocritical Aspects of the Works of the Lost Generation

Directory of Open Access Journals (Sweden)

Krisztina Sárdi

2015-12-01

Full Text Available This essay proposes to present and analyse the pictures or representations of Paris in Ernest Hemingway’s, Francis Scott Fitzgerald’s and Gertrude Stein’s different works. The theoretical framework of the piece is geocriticism by which the author attempts to discover how these works contributed to the literary construction of the French capital. The other objective of the essay is however to show the birth of a Parisian literary myth. After giving a brief overview of recent spatiality studies, the paper explains in-depth the geocritical method by the analysis of certain extracts of the different literary perceptions of Paris in the twenties, written by Francis Scott Fitzgerald (Babylon Revisited, Ernest Hemingway (A Moveable Feast and Gertrude Stein (Autobiography of Alice B. Toklas, Paris, France. The latter approach can help to shed some light on the reasons why these expatriates (American and British writers, artists came to Paris in the first place and what attracted them so much. Later on, the paper explains that the artists of the Lost Generation were disoriented and aimless after the war, so they headed to Paris to find some ‘old’ values and rebuild their lifes. These authors found there a new and very inspirational atmosphere, new friends, new goals, they started interesting publishing initiatives and searched for their proper literary voices. In the meantime, by representing the always exciting and crowded Parisian life, they created a literary myth of Paris which considers the city as safe haven for artists and writers – saying that Paris is a never resting “moveable feast”.

Proliferative verrucous leukoplakia; a critical appraisal of the diagnostic criteria

NARCIS (Netherlands)

Carrard, V.C.; Brouns, E.R.E.A.; van der Waal, I.

2013-01-01

Since its introduction in the literature in 1985, the term proliferative verrucous leukoplakia (PVL) has been the subject of an ongoing discussion with regard to its definition. Widespread or multifocal occurrence of oral leukoplakia is not just synonymous to PVL. In the present treatise the

Possible mechanisms for arsenic-induced proliferative diseases

Energy Technology Data Exchange (ETDEWEB)

Wetterhahn, K.E.; Dudek, E.J.; Shumilla, J.A. [Dartmouth College and Medical School, Hanover, NH (United States)] [and others

1996-12-31

Possible mechanisms for cardiovascular diseases and cancers which have been observed on chronic exposure to arsenic have been investigated. We tested the hypothesis that nonlethal levels of arsenic are mitogenic, cause oxidative stress, increase nuclear translocation of trans-acting factors, and increase expression of genes involved in proliferation. Cultured porcine vascular (from aorta) endothelial cells were used as a model cell system to study the effects of arsenic on the target cells for cardiovascular diseases. Treatment of postconfluent cell cultures with nonovertly toxic concentrations of arsenite increased DNA synthesis, similar to the mitogenic response observed with hydrogen peroxide. Within 1 hour of adding noncytotoxic concentrations of arsenite, cellular levels of oxidants increased relative to control levels, indicating that arsenite promotes cellular oxidations. Arsenite treatment increased nuclear translocation of NF-{kappa}B, an oxidative stress-responsive transcription factor, in a manner similar to that observed with hydrogen peroxide. Pretreatment of intact cells with the antioxidants N-acetylcysteine and dimethylfumarate prevented the arsenite-induced increases in cellular oxidant formation and NF-KB translocation. Arsenite had little or no effect on binding of NF-KB to its DNA recognition sequence in vitro, indicating that it is unlikely that arsenite directly affects NF-KB. The steady-state mRNA levels of intracellular adhesion molecule and urokinase-like plasminogen activator, genes associated with the active endothelial phenotype in arteriosclerosis and cancer metastasis, were increased by nontoxic concentrations of arsenite. These data suggest that arsenite promotes proliferative diseases like heart disease and cancer by activating oxidant-sensitive endothelial cell signaling and gene expression. It is possible that antioxidant therapy would be useful in preventing arsenic-induced cardiovascular disease and cancer.

Diagnostic value of ductogalactography and cytology in the proliferative changes of the mammary ducts

International Nuclear Information System (INIS)

Sessa, M.; Cerroni, L.; Bertolotti, A.

1991-01-01

Three hundred and thiyrty-six patients with nipple discharge and neither physical signs at breast examination nor pathological findings at mammography, were observed from 1984 to 1988 and studied by means of ductogalactography and cytology of discharge. Of this group, 76 patients (22%) underwent surgery and histology. In 65/76 cases proliferative pathologic conditions were demonstrated: 51 single/ multiple papillomas and 14 carcinomas. Ductogalactography suggested proliferative pathologic conditions in 59 cases and cytology of discharge showed blood in 44 patients, papillary clusters in 23, and atypical cells in 15 (both as single occurrences and in association). In cancer patients discharge appeared to be mostly spontaneous, monoductal and blood-stained. In papillomas, induced discharge was almost as frequent as spontaneous discharge, and milky discharge was also present. Ductogalactography confirmed its value in the diagnosis of proliferative pathologic conditions of the mammary ducts, being especially useful to detect carcinomas without palpable tumors. Cytology of discharge had poorer diagnostic significance

LITERARY LANGUAGE AS A SIGN. SEMIOTIC CONSIDERATIONS ON THE CROATIAN LANGUAGE IN THE CULTURAL SYSTEM

Directory of Open Access Journals (Sweden)

Maciej Czerwiński

2011-01-01

Full Text Available In the article the question of the existence of the Croatian literary language in the semiotic space, i.e. the system of culture, is taken into consideration. In order to affirm the idea of the justification of the very term Croatian language, and thus acceptance of the thesis of the existence of such a language, this argumentation is directed towards theoretical investigation in the semiotic field. There is an attempt to envisage that discussions in the post-Yugoslav linguistics are not the problem, conventionally speaking, ‘ontological’ but ‘epistemological’. Thus, it is not important the question whether the Croatian language or any other language, e.g. Montenegrin, exists but rather the following question: what does it mean that literary language exists or does not exist?

Literary Translation, Translating Culture: The Case of Shahriyar, the Famous Iranian Azeri Poet

Science.gov (United States)

Kianbakht, Saijad

2016-01-01

A literary translation is a device of art used to release the text from its dependence on prior cultural knowledge (Herzfeld, 2003). The present research investigates the use of pragmatic equivalence in two translations of the Azeri Turkish long poem "Haydar Babaye Salam" by "Shahriyar." Based on Koller's theory of equivalence…

Utterance and Function in Genre Studies: A Literary Perspective

DEFF Research Database (Denmark)

Auken, Sune

2015-01-01

of the complexities involved when Genre Studies confront genres whose utterances are more complex than the “homely discourses” usually discussed in RGS. Formal and thematic features play a far too significant role in literary works to be explicable simply as derivations from function alone. But this is not limited...... to formal and thematic interpretations of genre, by allowing the utterances themselves to re-enter center stage. This enables an improved understanding of complex genres. It also revives close reading as a viable approach to understanding genre and thus to inform the rhetorical, linguistic, and sociological...

Chemical Constituents from Cimicifuga dahurica and Their Anti-Proliferative Effects on MCF-7 Breast Cancer Cells

Directory of Open Access Journals (Sweden)

Chu Thi Thanh Huyen

2018-05-01

Full Text Available This study was designed to search for novel anti-cancer compounds from natural plants. The 70% ethanolic extract from the rizhomes of Cimicifuga dahurica (Turcz. Maxim. (Ranunculaceae was found to possess significant in vitro anti-proliferative effects on MCF-7 breast cancer cells. A phytochemical investigation using assay-guided fractionation of the ethanolic extract of C. dahurica resulted in the isolation of one new phenolic amide glycoside 3, two new lignan glycosides 4 and 7, one new 9,19-cycloartane triterpenoid glycoside 6, and thirteen known constituents 1, 2, 5, and 8–17. The structures of 3, 4, 6, and 7 were established using contemporary NMR methods and from their HRESIMS data. The anti-proliferative effects of isolated compounds were evaluated using the BrdU-proliferation kit. Five among the 17 isolated compounds showed significant anti-proliferative effects (p ≤ 0.05, wherein compound 7 showed the most significant anti-proliferative and cell cycle arresting effect (p ≤ 0.05 which followed a dose dependent manner. Western blot protein expression analysis showed a down expression of c-Myc and cyclin D1 which further elucidated the anti-proliferation mechanism of compound 7 while apoptotic effects were found in association with Bcl-2 family protein expression variations. Conclusively this study reports the isolation and identification of 17 compounds from C. dahurica, including four novel molecules, in addition to the fact that compound 7 possesses significant anti-proliferative and apoptotic effects in vitro that may require further exploration.

“There’s never any ending to Paris” Creating a Literary Myth: Geocritical Aspects of the Works of the Lost Generation

Directory of Open Access Journals (Sweden)

Krisztina Sárdi

2015-12-01

Full Text Available This essay proposes to present and analyse the pictures or representations of Paris in Ernest Hemingway’s, Francis Scott Fitzgerald’s and Gertrude Stein’s different works. The theoretical framework of the piece is geocriticism by which the author attempts to discover how these works contributed to the literary construction of the French capital. The other objective of the essay is however to show the birth of a Parisian literary myth. After giving a brief overview of recent spatiality studies, the paper explains in-depth the geocritical method by the analysis of certain extracts of the different literary perceptions of Paris in the twenties, written by Francis Scott Fitzgerald (Babylon Revisited, Ernest Hemingway (A Moveable Feast and Gertrude Stein (Autobiography of Alice B. Toklas, Paris, France. The latter approach can help to shed some light on the reasons why these expatriates (American and British writers, artists came to Paris in the first place and what attracted them so much. Later on, the paper explains that the artists of the Lost Generation were disoriented and aimless after the war, so they headed to Paris to find some ‘old’ values and rebuild their lifes. These authors found there a new and very inspirational atmosphere, new friends, new goals, they started interesting publishing initiatives and searched for their proper literary voices. In the meantime, by representing the always exciting and crowded Parisian life, they created a literary myth of Paris which considers the city as safe haven for artists and writers – saying that Paris is a never resting “moveable feast”.  

CONTEMPORARY INDIGENOUS LITERATURE: FORMS AND CONTENTS IN THE POETRY AND PROSE OF THE II LITERARY PARTY OF INDIGENOUS POETICS.

Directory of Open Access Journals (Sweden)

Deborah Goldemberg

2010-06-01

Full Text Available By analyzing the forms and contents of the presentations made by indigenous performers and writers at the I Literary Party of Indigenous Poetics, this article exposes the challenges faced by traditional genre theories in tackling indigenous narratives and analyses how this “crisis” contributes to widening hierarchical and Western biased conceptions. On a stage open to contemporary indigenous expression, as is the literary party, the concepts of performance and storytelling, with the social function of maintaining tradition, continuous learning and transformation, better define this indigenous expression.

Aldo Castellani, ed. Nuovi canti carnascialeschi di Firenze. Le “canzone” e mascherate di Alfonso de’ Pazzi. Firenze: Olschki Editore, 2006. Pp. 295.`(Bookreview)

NARCIS (Netherlands)

Werner, I.M.

2007-01-01

Alfonso de’ Pazzi (1509-55) was one of the members of the Accademia Fiorentina and the literary scene of sixteenth-century Florence who has remained virtually neglected during the twentieth century. When scholars did refer to him, it was mainly because of his fame as a prolific writer of poems

More than words: applying the discipline of literary creative writing to the practice of reflective writing in health care education.

Science.gov (United States)

Kerr, Lisa

2010-12-01

This paper examines definitions and uses of reflective and creative writing in health care education classrooms and professional development settings. A review of articles related to writing in health care reveals that when teaching narrative competence is the goal, creative writing may produce the best outcomes. Ultimately, the paper describes the importance of defining literary creative writing as a distinct form of writing and recommends scholars interested in using literary creative writing to teach narrative competence study pedagogy of the field.

What Reader-Oriented Literary and Cognitive Theories Have to Give to Composing Theory.

Science.gov (United States)

Liebman-Kleine, JoAnne

In developing an interactive model of composing, this paper discusses three groups of reader-oriented theories, each of which provides composing theorists with some research and theory to use in developing such a model. First the paper discusses the main principle of the literary reader-response theorists--that the meaning and value of texts do…

Changes in retinal venular oxygen saturation predict activity of proliferative diabetic retinopathy 3 months after panretinal photocoagulation.

Science.gov (United States)

Torp, Thomas Lee; Kawasaki, Ryo; Wong, Tien Yin; Peto, Tunde; Grauslund, Jakob

2018-03-01

Proliferative diabetic retinopathy (PDR) is a severe blinding condition. We investigated whether retinal metabolism, measured by retinal oximetry, may predict PDR activity after panretinal laser photocoagulation (PRP). We performed a prospective, interventional, clinical study of patients with treatment-naive PDR. Wide-field fluorescein angiography (OPTOS, Optomap) and global and focal retinal oximetry (Oxymap T1) were performed at baseline (BL), and 3 months (3M) after PRP. Angiographic findings were used to divide patients according to progression or non-progression of PDR after PRP. We evaluated differences in global and focal retinal oxygen saturation between patients with and without progression of PDR after PRP treatment. We included 45 eyes of 37 patients (median age and duration of diabetes were 51.6 and 20 years). Eyes with progression of PDR developed a higher retinal venous oxygen saturation than eyes with non-progression at 3M (global: +5.9% (95% CI -1.5 to 12.9), focal: +5.4%, (95% CI -4.1 to 14.8)). Likewise, progression of PDR was associated with a lower arteriovenular (AV) oxygen difference between BL and 3M (global: -6.1%, (95% CI -13.4 to -1.4), focal: -4.5% (95% CI -12.1 to 3.2)). In a multiple logistic regression model, increment in global retinal venular oxygen saturation (OR 1.30 per 1%-point increment, p=0.017) and decrement in AV oxygen saturation difference (OR 0.72 per 1%-point increment, p=0.016) at 3M independently predicted progression of PDR. Development of higher retinal venular and lower AV global oxygen saturation independently predicts progression of PDR despite standard PRP and might be a potential non-invasive marker of angiogenic disease activity. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Reproducibility and convergences in the cyberspace: the diffusion of literary texts in television adaptations

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Líliam Cristina Marins Prieto

2014-03-01

Full Text Available In this study, multimodal circulation of literary texts in television adaptations is outlined, emphasizing their implications in the conceptualization and value judgment in the Arts (particularly in Literature. The technological boom in several social segments and new reading practices in the current information revolution age have influenced the circulation of literature in new forms and intersemiotic medias. By congregating theories about cyberculture and media convergence (Negroponte, Lévy and Jenkins and the analysis of specific cases, such as the adaptation of Shakespeare´s The Taming of the Shrew (1593 in O Cravo e a Rosa (2000, a Brazilian telenovela directed by Walcyr Carrasco and Mário Teixeira, a new cultural context emerges. In this new configuration where television and cyberspace are part of the convergence culture, the media and their users interact. This interaction contributes towards the survival of the literary text and the emergence of new reading practices.

Micromégas: Altered Body-Environment Scaling in Literary Fiction.

Science.gov (United States)

Dieguez, Sebastian

2016-01-01

Architectonic embodiment postulates a bidirectional link between bodily awareness and the architectural environment. The standard size and features of the human body, for instance, are thought to influence the structure of interiors and buildings, as well as their perception and appreciation. Whereas architectural practice and theory, the visual arts and more recently the cognitive sciences have explored this relationship of humans with their crafted environments, many fictional literary works have long experimented with alterations of body-environment scaling. This so-called Gulliver theme - popular in the science-fiction genre but also in children's literature and philosophical satire - reveals, as a recurrent thought-experiment, our preoccupation with proportions and our fascination for the infinitely small and large. Here I provide an overview of the altered scaling theme in literature, including classics such as Voltaire's Micromégas, Swift's Gulliver's Travels, Caroll's Alice, and Matheson's The Shrinking man, closely examining issues relevant to architectonic embodiment such as: bodily, perceptual, cognitive, affective, and social changes related to alterations in body size relative to people, objects and architectural environments. I next provide a taxonomy of the Gulliver theme and highlight its main psychological features, and then proceed to review relevant work from cognitive science. Although fictional alterations of body-environment scaling far outreach current possibilities in experimental research, I argue that the peripetiae and morals outlined in the literary realm, as products of the human imagination, provide a unique window into the folk-psychology of body and space.

A lentiviral vector with expression controlled by E2F-1: A potential tool for the study and treatment of proliferative diseases

International Nuclear Information System (INIS)

Strauss, Bryan E.; Patricio, Juliana Rotelli; Vieira de Carvalho, Anna Carolina; Bajgelman, Marcio C.

2006-01-01

We have constructed a lentiviral vector with expression limited to cells presenting active E2F-1 protein, a potential advantage for gene therapy of proliferative diseases. For the FE2FLW vector, the promoter region of the human E2F-1 gene was utilized to drive expression of luciferase cDNA, included as a reporter of viral expression. Primary, immortalized, and transformed cells were transduced with the FE2FLW vector and cell cycle alterations were induced with serum starvation/replacement, contact inhibition or drug treatment, revealing cell cycle-dependent changes in reporter activity. Forced E2F-1 expression, but not E2F-2 or E2F-3, increased reporter activity, indicating a major role for this factor in controlling expression from the FE2FLW virus. We show the utility of this vector as a reporter of E2F-1 and proliferation-dependent cellular alterations upon cytotoxic/cytostatic treatment, such as the introduction of tumor suppressor genes. We propose that the FE2FLW vector may be a starting point for the development of gene therapy strategies for proliferative diseases, such as cancer or restinosis

Proliferative thyroid lesions in three diplodactylid geckos: Nephrurus amyae, Nephrurus levis, and Oedura marmorata.

Science.gov (United States)

Hadfield, Catherine A; Clayton, Leigh A; Clancy, Meredith M; Beck, Sarah E; Mangus, Lisa M; Montali, Richard J

2012-03-01

Over a 5-mo period, three diplodactylid geckos housed at the National Aquarium were diagnosed with proliferative thyroid lesions: a rough knob-tail gecko (Nephrurus amyae), a smooth knob-tail gecko (Nephrurus levis), and a marbled velvet gecko (Oedura marmorata). Clinical signs included an intraoral mass or ventral throat swelling (or both), oral bleeding, and weight loss. Both of the knob-tail geckos died. The histologic diagnosis for the rough knob-tail gecko was thyroid carcinoma with metastases to the liver and lungs, and thyroid carcinoma with no metastases was reported in the smooth knob-tail gecko. A thyroidectomy was performed on the marbled velvet gecko with a histologic diagnosis of adenomatous hyperplasia. Postoperative weight loss and bradycardia resolved following oral supplementation with levothyroxine. The animal is in normal health 10 mo post-surgery. Five other diplodactylid geckos in the collection remain unaffected, giving a 38% prevalence of proliferative thyroid lesions (3/8). The etiology remains undetermined. This is the first report of a cluster of proliferative thyroid lesions in geckos.

Revealing to Translate: The Intertextuality and Strategic Nature of Voices, Presuppositions and Metadiscourse in a Non-Literary Text

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Didem TUNA

2017-12-01

Full Text Available Reading a literary text might be considered to be mostly based on reading the implicit, the inferential, the implicative, and the inarticulate, rather than the explicit, the obvious, or the outspoken. Beyond what is apparent on the surface, the text of a literary work usually has equivoques, metaphors, symbols, enigmas, undertones, implications, inferential components, and different kinds of involvements and complications as well as intertextual aspects and the difference between appearance, perception, and reality. Translating a text requires, above all, comprehending it, and various applications of analysis are employed in this respect. Although a non-literary text is not usually expected to have as many pieces to put together or variables and constituents to bring to light as a literary one, it still needs to be read critically; the characters and the voices in it need to be identified and canvassed. In addition, the degree of responsibility that the writer assumes or avoids in each part of the text needs to be detected. Analysis becomes particularly significant when translation is in question because to be able to fully reflect the source text’s particularities in the translated text, the translator needs to discover its singularity and specifications with its strategic and purposeful elements. Teaching by Principles: An Interactive Approach to Language Pedagogy by H. Douglas Brown is a textbook written for “prospective and new teachers who need to learn how to walk into a classroom and effectively accomplish communicative objectives” (Brown, 2000: xi-xii. Throughout the book’s section entitled Cheating in the chapter concerning classroom management, the existence of the implicit in a non-literary texts is pinpointed using the concepts of presupposition and metadiscourse as discussed by Norman Fairclough within the framework of intertextuality. In addition, characters and voices in the text are examined. The instances of the

Revealing to Translate: The Intertextuality and Strategic Nature of Voices, Presuppositions and Metadiscourse in a Non-Literary Text

Directory of Open Access Journals (Sweden)

Didem TUNA

2017-09-01

Full Text Available Reading a literary text might be considered to be mostly based on reading the implicit, the inferential, the implicative, and the inarticulate, rather than the explicit, the obvious, or the outspoken. Beyond what is apparent on the surface, the text of a literary work usually has equivoques, metaphors, symbols, enigmas, undertones, implications, inferential components, and different kinds of involvements and complications as well as intertextual aspects and the difference between appearance, perception, and reality. Translating a text requires, above all, comprehending it, and various applications of analysis are employed in this respect. Although a non-literary text is not usually expected to have as many pieces to put together or variables and constituents to bring to light as a literary one, it still needs to be read critically; the characters and the voices in it need to be identified and canvassed. In addition, the degree of responsibility that the writer assumes or avoids in each part of the text needs to be detected. Analysis becomes particularly significant when translation is in question because to be able to fully reflect the source text’s particularities in the translated text, the translator needs to discover its singularity and specifications with its strategic and purposeful elements. Teaching by Principles: An Interactive Approach to Language Pedagogy by H. Douglas Brown is a textbook written for “prospective and new teachers who need to learn how to walk into a classroom and effectively accomplish communicative objectives” (Brown, 2000: xi-xii. Throughout the book’s section entitled Cheating in the chapter concerning classroom management, the existence of the implicit in a non-literary texts is pinpointed using the concepts of presupposition and metadiscourse as discussed by Norman Fairclough within the framework of intertextuality. In addition, characters and voices in the text are examined. The instances of the

PRACTICE OF USING DIFFERENT WAYS OF ANALYSIS OF A FICTION WORK AT LITERARY READING LESSONS

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Valeriy Syrotenko

2017-04-01

Full Text Available Analysis of a fiction work at school, in particular in primary school, is based on the methodological studies of the literary analysis, that envisages application of various ways of analysis of a literary text used for the adequate appreciation of its semantic and expressive features. This article is devoted exactly to this range of problems. Literary reading lessons in 2-4th forms set a task of forming schoolchildren’s literary competence, the integral part of which is their ability to analyse various fiction works. We mean here a number of theoretic and methodological researches, nevertheless ways of analysis of the fiction text and methodology of its realization in primary school are not examined essentially. Therefore, we offer the following ways of analysis: character drawing, problem and thematic approach and holistic approach that are used taking into account the form (character drawing approach is the simplest one and it is suitable for the 2nd year pupils, while holistic one can be appropriate for the 4th year pupils and genre of work. A verse by P. Voronko “In the field there is a green house” (the 2nd form is studied with the help of character drawing because the story of the verse (a little bear misbehaves because he does not want to sleep, and his mother sings him a lullaby is close to a 7-8-year-old child by its semantic genre; moreover, there are a few characters in the verse, and they require an additional discussion. Therefore, for creating the proper emotional atmosphere in the class one should consider the following methodical forms of work: heuristic conversation, connecting the little bear’s dominant traits of the character, his mother, and grandfather Sleep, that will help children understand the main traits of every character, their role in work, and also the originality of the verse genre. The work ends with a questionnaire children are suggested working in pairs to analyse the behavior of a child in various

Cell structure and proliferative activity of organ cultures of normal embryonic lung tissue of mice resistant (C57BL) and predisposed (A) to lung tumors

International Nuclear Information System (INIS)

Kolesnichenko, T.S.; Gor'kova, T.G.

1985-01-01

Local factors such as proliferative activity and the numerical ratio between epithelial and mesenchymal cells, and also the character of interaction between the tissue components in ontogeny may play an important role in the realization of sensitivity of mice of a particular line to the development of lung tumors. These characteristics of lung tissue in mice of lines A and C57BL are investigated under normal conditions and during induced carcinogenesis. Results are given of a comparative study of the relative numbers of epithelial and mesenchymal cells in organ cultures of embryonic lungs. 3 H-thymidine was added to the cultures on the 14th day of the experiment in a concentration of 1 microCi/m1 medium. An autoradiographic study of the cultures was performed

Proliferative activity (MIB-1 index) is an independent prognostic parameter in patients with high-grade soft tissue sarcomas of subtypes other than malignant fibrous histiocytomas

DEFF Research Database (Denmark)

Jensen, V; Sørensen, Flemming Brandt; Bentzen, S M

1998-01-01

. The proliferative activity was assessed by use of the monoclonal antibody MIB-1 and evaluated in multiple, random systematic sampled fields of vision. The percentage of proliferating cells (the MIB-1 index) ranged between 1% and 85% (median 12%). A significant increase in mean MIB-1 index was seen with increasing...... histological malignancy grade. Variation in the incidence of p53 accumulation and bcl-2 positivity among different histological subtypes was observed. p53 accumulation was frequent in synovial sarcomas and leiomyo- and rhabdomyosarcomas, whereas bcl-2 preferentially was expressed in synovial sarcomas....... Univariate analysis identified patient age, tumour size, histological grade of malignancy, MIB-1 index and p53 accumulation as significant prognostic parameters. Multivariate Cox analysis, including tests for interaction terms between histological subtypes and MIB-1 index, showed independent prognostic...

The Debate over Literary Tamil versus Standard Spoken Tamil: What Do Teachers Say?

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Saravanan, Vanithamani; Lakshmi, Seetha; Caleon, Imelda S.

2009-01-01

This study aims to determine the attitudes toward Standard Spoken Tamil (SST) and Literary Tamil (LT) of 46 Tamil teachers in Singapore. The teachers' attitudes were used as an indicator of the acceptance or nonacceptance of SST as a viable option in the teaching of Tamil in the classroom, in which the focus has been largely on LT. The…

Evaluation of the anti-proliferative and cytostatic effect of Citrus sinensis (orange) fruit juice.

Science.gov (United States)

Chinedu, Enegide; Arome, David; Ameh, Solomon F; Ameh, Gift E

2014-09-01

This work has been designed to evaluate the anti-proliferative and cytostatic effects of Citrus sinensis (orange) fruit juice on rapidly proliferating cells. The study was carried out on the seeds of Sorghum bicolor for 72 h. The mean radicle length (mm) of the seeds was taken at 48 and 72 h. The result showed that when compared with the control, methotrexate, the standard drug showed a significant (P < 0.001) anti-proliferative effect throughout the experiment. The inhibition of the radicle growth was more after 72 h (87.42%). At a dose of 5% (v/v), the juice showed a slightly significant (P < 0.05) effect affect after 72 h; however, there was no significant effect at 48 h. The juice at doses of 10% and 20% (v/v) showed a highly significant (P < 0.001) anti-proliferative effect throughout the experiment; however, the percentage inhibitions were higher at 72 h. At 72 h, the percentage inhibition for juice at 10% (v/v) was 72.37% and at 20% (v/v) was 91.96%. The concentrations of 40% and 60% (v/v) showed cytostatic effects as no appreciable growth of the radicles of the seeds was observed throughout the experiment. The percentage inhibition for 40% (v/v) was 100% and 99.72% for 48 and 72 h, respectively, while that for the juice concentration of 60% (v/v) was 100% throughout the study. The experiment has shown that C. sinensis fruit juice has a potential for causing both anti-proliferative and cytostatic effects on fast proliferating cells and hence cancerous cells.

Protein metabolism of prolific ewes during late gestation and early lactation

NARCIS (Netherlands)

Sebek, L.B.J.

2001-01-01

Subject headings: protein / metabolism / ewes

Introduction of prolific crossbred ewes and a new protein evaluation system for ruminants, the DVE/OEB system, necessitate a reconsideration of ewe feeding strategies. The objective of this thesis is to investigate the amount

The effect of beta-hydroxy-beta-methylbutyrate (HMB) on the proliferative response of blood lymphocytes and the phagocytic activity of blood monocytes and granulocytes in calves.

Science.gov (United States)

Wójcik, R; Małaczewska, J; Siwicki, A K; Miciński, J; Zwierzchowski, G

2013-01-01

The objective of this study was to evaluate the effect of HMB on selected indicators of immunity in calves. The experiment was performed on 14 calves aged 30 +/- 2 days, divided into two equal groups of control (group I) and experimental (group II) animals. The feed administered to experimental group calves was supplemented with HMB at 40 mg/kg BW, whereas control calves were administered standard farm-made feed without supplementation. Blood was sampled from the jugular vein immediately before the experiment (day 0) and on experimental days 15, 30 and 60 to determine the following parameters of immunity: proliferative response of LPS- and ConA-stimulated lymphocytes (MTT), respiratory burst activity (RBA) and potential killing activity (PKA) of phagocytes. The results revealed a significant increase in RBA and MTT values in calves administered HMB in comparison with the control group throughout the experiment. In the group of animals receiving HMB, an increase in PKA values was noted only on day 30.

Neoplastic and proliferative disorders of the perinephric space

International Nuclear Information System (INIS)

Heller, M.T.; Haarer, K.A.; Thomas, E.; Thaete, F.L.

2012-01-01

The perinephric space is a well-marginated central compartment of the retroperitoneum, located between the anterior and posterior pararenal spaces. Various neoplastic and proliferative disorders can affect the perinephric space, and there is a wide array of imaging findings. Although many perinephric lesions may extend directly from the kidney and adrenal gland, other lesions occur in the perinephric space due to haematogenous spread, as part of a systemic disease, or by extension from an adjacent retroperitoneal compartment. Imaging plays a pivotal role in the diagnosis of perinephric diseases, as many of the disease processes affecting this space will not result in clinical signs or symptoms until the disease is at an advanced stage. Despite the often shared non-specific clinical and imaging findings among these disease processes, application of a categorical differential diagnosis based on the imaging characteristics will serve to narrow the differential diagnosis and direct further evaluation and treatment. In this article, the lesions have been categorized as soft-tissue rind [nephroblastomatosis, fibrosis, Erdheim–Chester disease (ECD), extramedullary haematopoiesis, lymphoma, infiltrating metastases], focal solid lesions (extension of renal or adrenal malignancies, melanoma metastases, treated lymphoma), fat-containing lesions (angiomyolipoma, liposarcoma, myelolipoma), and cystic lesions (lymphangiomas, abscesses). The aim of this article is to demonstrate and describe the key imaging features of several neoplastic and proliferative disorders that affect the perinephric space.

To report a case of unilateral proliferative retinopathy following noncerebral malaria with Plasmodium falciparum in Southern India

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Aditya Verma

2015-01-01

Full Text Available The retinopathy in association with malaria fever described so far includes retinal hemorrhages, vessel changes, retinal discoloration/whitening and papilledema. Malaria retinopathy has been mostly described in severe cases, associated with Plasmodium falciparum, correlating the patho-physiology of retinal and cerebral manifestations. We report an unusual case of proliferative retinopathy as a manifestation of malaria fever, caused by P. falciparum with no cerebral involvement. The patient had features of unilateral retinal vascular occlusion with proliferative changes and vitreous hemorrhage. To the best of our knowledge, such a case has never been reported so far in the literature. This report highlights the possible occurrence of severe proliferative changes associated with malaria fever, which if diagnosed early can prevent possible blindness.

Rehabilitation effect of oral drug on the patients with proliferative diabetic retinopathy after operation

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Wei Zu

2014-08-01

Full Text Available AIM:To observe the rehabilitation effect of oral Calcium Dobesilate Tablets and Epalrestat Tablets on the proliferative diabetic retinopathy(PDRpatients after vitrectomy.METHODS: After vitrectomy patients informed consent, they were randomly divided into intervention group and control group, and their vision and fundus were followed up and compared at 2d; 3, 6, 9, 12mo after operation.RESULTS: The recovery and sustainment of visual acuity, and subsiding of macular edema of patients in drug intervention group were significantly better than that in control group.CONCLUSION: PDR patients after vitrectomy actively orally take medicine to protect retina, which can improve vision and fundus rehabilitation.

Evolving Lattices for Analyzing Behavioral Dynamics of Characters in Literary Text

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Eugene S Kitamura

2011-10-01

Full Text Available This paper is about an application of rough set derived lattices in order to analyze the dynamics of literary text. Due to the double approximation nature of rough set theory, a pseudo-closure obtained from two different equivalence relations allows us to form arbitrary lattices. Moreover, such double approximations with different equivalence relations permit us to obtain lattice fixed points based on two interpretations. The two interpretations used for literary text analysis are subjects and their attributes. The attributes chosen for this application are verbs. The progression of a story is defined by the sequence of verbs (or event occurrences. By fixing a window size and sliding the window down the story steps, we obtain a lattice representing the relationship between subjects and their attributes within that window frame. The resulting lattice provides information such as complementarity (lattice complement existence rate and distributivity (lattice complement possession rate. These measurements depend on the overlap and the lack of overlap among the attributes of characters. As the story develops and new character and attributes are provided as the source of lattices, one can observe its evolution. In fact, a dramatic change in the behavior dynamics in a scene is reflected in the particular shifts in the character-attribute relationship. This method lets us quantify the developments of character behavioral dynamics in a story.

The Necessity of the Literary Tradition: Gabriel Garcia Marquez's "One-Hundred Years of Solitude."

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Jupp, James C.

2000-01-01

Argues that literature from other countries, taught as multicultural literature, must be taught in the context of its own literary tradition in order to provide high-quality academic instruction. Offers an example with Gabriel Garcia Marquez's "One-Hundred Years of Solitude" to show how teaching multicultural literature can live up to…

The Effect of Reading a Short Passage of Literary Fiction on Theory of Mind: A Replication of Kidd and Castano (2013

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Iris van Kuijk

2018-02-01

Full Text Available The results reported by Kidd and Castano (2013 indicated that reading a short passage of literary fiction improves theory of mind (ToM relative to reading popular fiction. However, when we entered Kidd and Castano’s results in a 'p'-curve analysis, it turned out that the evidential value of their findings is low. It is good practice to back up a p-curve analysis of a single paper with an adequately powered direct replication of at least one of the studies in the 'p'-curve analysis. Therefore, we conducted a direct replication of the literary fiction condition and the popular fiction condition from Kidd and Castano’s Experiment 5 to scrutinize the effect of reading literary fiction on ToM. The results of this replication were largely consistent with Kidd and Castano’s original findings. Furthermore, we conducted a small-scale meta-analysis on the findings of the present study, those of Kidd and Castano and those reported in other published direct replications. The meta-analytic effect of reading literary fiction on ToM was small and non-significant but there was considerable heterogeneity between the included studies. The results of the present study and of the small-scale meta-analysis are discussed in the light of reading-times exclusion criteria as well as reliability and validity of ToM measures.

Review Essay: The Socio-Analysis of Literary Texts as a Method of Qualitative Social Research, or: What Is the Reality in Fiction?

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Maja Suderland

2013-11-01

Full Text Available With his 1,200+ page study of Robert Musil's novel "The Man Without Qualities," Norbert Christian Wolf has produced a book which many may assume is "unreadable" on account of its enormous size alone. As a work of literary studies, it certainly runs the risk of being largely ignored by the social sciences. From a methodological perspective, however, there are good reasons to engage with this book: Not only does it contain a concise theoretical substantiation and methodological description of the socio-analysis of literary texts according to Pierre Bourdieu, it also demonstrates this method in detail on the corpus of the fictional characters in Musil's novel. In terms of literary studies, Wolf's book can therefore be viewed as a kind of encyclopedia for Musil's work; sociologically, it represents a nuanced socio-analysis of the "history of the calamities of the 20th century." Before looking at the methodological and methodical aspects of Wolf's study, this review essay presents some introductory thoughts on the use of literary works in the social sciences as well as a few cursory references to selected works which introduce or make use of this method themselves. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1401205

De la primera lengua a la traducción literaria: Itinerarios de evaluación y reescritura creativa / From mother tongue teaching to literary translation: Assessing and creative rewriting

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Jorge J. SÁNCHEZ IGLESIAS

2012-03-01

Full Text Available Esta propuesta parte de las particularidades de la formación en Lengua A para Traductores, un ámbito poco definido y normalmente muy alejado de los contenidos literarios. Se plantean dos conjuntos de actividades, vinculados a la evaluación y a la reescritura, de cuya vinculación surgen los conceptos de lectura intencional y desautomatización de la escritura, y que parecen por tanto especialmente adecuadas para fomentar una creatividad en el uso de la lengua que resulta de la mayor importancia para la traducción literaria. A partir de unas primeras experimentaciones con reescritura de textos literarios, se puede concluir que las nociones de tono y estilo están intuitivamente disponibles para los escritores noveles y son por tanto excelentes candidatas para ser operativas en la formación en traducción literaria.  The distinguishing characteristics of First Language training - a vaguely defined area of study which is not usually explored in literary publications - will form the basis of our investigation.  We will consider two sets of activities, both linked to evaluation and rewriting, which will allow us to explore the concepts of intentional reading and deautomisation of the writing process. These notions seem especially useful for encouraging creativity in language use, a highly important skill in literary translation. Based on the results of a few initial experiments involving the rewriting of literary texts, we can conclude that novice writers are intuitively aware of tone and style. These notions could therefore provide an excellent focus for literary translation training. 

Serbian Literary Magazine and avant-garde music

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Vasić Aleksandar N.

2005-01-01

Full Text Available One of the most excellent periodicals in the history of Serbian literature Serbian Literary Magazine (1901-1914, 1920-1941, also played an exceptionally important part in the history of Serbian music criticism and essay literature. During the period of 35 years, SLM had released nearly 800 articles about music. Majority of that number belongs to the music criticism, but there are also studies and essays about music ethno musicological treatises, polemics, obituary notices, as well as many ample and diverse notes. SLM was published during the time when Serbian society, culture and art were influenced by strong challenges of Europeanization and modernization. Therefore, one of the most complicated questions that music writers of this magazine were confronted with was the question of avant-garde music evaluation. Relation of critics and essay writers to the avant-garde was ambiguous. On one side, SLM's authors accepted modern art in principle, but, on the other side, they questioned that acceptance when facing even a bit radical music composition. This ambivalence as a whole marked the work of Dr Miloje Milojević, the leading music writer of SLM. It is not the same with other critics and essayists Kosta Manojlović was more tolerant, and Dragutin Čolić and Stanislav Vinaver were true protectors of the most avant-garde aspirations in music. First of all SLM was a literary magazine. In the light of that fact it has to be pointed out that very early, way back in 1912, critics wrote about Arnold Schoenberg, and that until the end of existence of this magazine the readers were regularly informed about all important avant-garde styles and composers of European, Serbian and Yugoslav music. The fact that Schoenberg Stravinsky, Honegger or Josip Slavenski mostly were not accepted by critics and essayists, expresses the basic aesthetic position of this magazine. Namely, SLM remained loyal to the moderate wing of modern music, music that had not rejected

Changes in the Proliferative Program Limit Astrocyte Homeostasis in the Aged Post-Traumatic Murine Cerebral Cortex.

Science.gov (United States)

Heimann, Gábor; Canhos, Luisa L; Frik, Jesica; Jäger, Gabriele; Lepko, Tjasa; Ninkovic, Jovica; Götz, Magdalena; Sirko, Swetlana

2017-08-01

Aging leads to adverse outcomes after traumatic brain injury. The mechanisms underlying these defects, however, are not yet clear. In this study, we found that astrocytes in the aged post-traumatic cerebral cortex develop a significantly reduced proliferative response, resulting in reduced astrocyte numbers in the penumbra. Moreover, experiments of reactive astrocytes in vitro reveal that their diminished proliferation is due to an age-related switch in the division mode with reduced cell-cycle re-entry rather than changes in cell-cycle length. Notably, reactive astrocytes in vivo and in vitro become refractory to stimuli increasing their proliferation during aging, such as Sonic hedgehog signaling. These data demonstrate for the first time that age-dependent, most likely intrinsic changes in the proliferative program of reactive astrocytes result in their severely hampered proliferative response to traumatic injury thereby affecting astrocyte homeostasis. © The Author 2017. Published by Oxford University Press.

Christopher Benfey's Flight of Fancy

Science.gov (United States)

Klein, Julia M.

2008-01-01

This article profiles Christopher Benfey, 53--an art critic for Slate, a poet, and a prolific literary essayist for such venues as "The New York Times Book Review, The New Republic," and "The New York Review of Books." His latest book, "A Summer of Hummingbirds: Love, Art, and Scandal in the Intersecting Worlds of Emily…

Women Authors with/without Gender Studies: the Gendered Regimes of Authority in Hungarian Literary Criticism Today

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Györgyi Horváth

2011-01-01

Full Text Available While in contemporary Hungarian literature women authors are constantly emerging and make themselves much more visible than ever before, the gender bias underlying literary evaluations seem to remain nearly intact. In her study Györgyi Horváth discusses three aspects of the gendered regimes of authority in order to give deeper insights into how gender bias re-produces within the Hungarian context. First, she focuses on lists of literary prize winners and critical rankings of published works (showing how many women writers are present on such lists in absolute numbers and in what percentages, and how their numbers have changed over time. Secondly, she explores the practice of critique writing itself, by analyzing the book review pages in two literary journals between 2007 and 2009 focusing on cases when the issue of “gender” itself comes up in the rhetoric of critics trying to underpin their aesthetic judgments on a given work. And finally, she examines briefly the attitude of contemporary women writers towards Gender Studies. Horváth concludes that Gender Studies in Hungary has not contributed significantly to increasing the prestige of contemporary women writers, most of whom, in turn, do not want to be involved with Gender Studies or feminism at all. She also points out that at present in Hungary there is a general blindness in understanding how gender/power relations permeate aesthetic judgments.

Micromégas: Altered Body–Environment Scaling in Literary Fiction

Science.gov (United States)

Dieguez, Sebastian

2016-01-01

Architectonic embodiment postulates a bidirectional link between bodily awareness and the architectural environment. The standard size and features of the human body, for instance, are thought to influence the structure of interiors and buildings, as well as their perception and appreciation. Whereas architectural practice and theory, the visual arts and more recently the cognitive sciences have explored this relationship of humans with their crafted environments, many fictional literary works have long experimented with alterations of body–environment scaling. This so-called Gulliver theme – popular in the science-fiction genre but also in children’s literature and philosophical satire – reveals, as a recurrent thought-experiment, our preoccupation with proportions and our fascination for the infinitely small and large. Here I provide an overview of the altered scaling theme in literature, including classics such as Voltaire’s Micromégas, Swift’s Gulliver’s Travels, Caroll’s Alice, and Matheson’s The Shrinking man, closely examining issues relevant to architectonic embodiment such as: bodily, perceptual, cognitive, affective, and social changes related to alterations in body size relative to people, objects and architectural environments. I next provide a taxonomy of the Gulliver theme and highlight its main psychological features, and then proceed to review relevant work from cognitive science. Although fictional alterations of body-environment scaling far outreach current possibilities in experimental research, I argue that the peripetiae and morals outlined in the literary realm, as products of the human imagination, provide a unique window into the folk-psychology of body and space. PMID:27148156

Regional control of Drosophila gut stem cell proliferation: EGF establishes GSSC proliferative set point & controls emergence from quiescence.

Science.gov (United States)

Strand, Marie; Micchelli, Craig A

2013-01-01

Adult stem cells vary widely in their rates of proliferation. Some stem cells are constitutively active, while others divide only in response to injury. The mechanism controlling this differential proliferative set point is not well understood. The anterior-posterior (A/P) axis of the adult Drosophila midgut has a segmental organization, displaying physiological compartmentalization and region-specific epithelia. These distinct midgut regions are maintained by defined stem cell populations with unique division schedules, providing an excellent experimental model with which to investigate this question. Here, we focus on the quiescent gastric stem cells (GSSCs) of the acidic copper cell region (CCR), which exhibit the greatest period of latency between divisions of all characterized gut stem cells, to define the molecular basis of differential stem cell activity. Our molecular genetic analysis demonstrates that the mitogenic EGF signaling pathway is a limiting factor controlling GSSC proliferation. We find that under baseline conditions, when GSSCs are largely quiescent, the lowest levels of EGF ligands in the midgut are found in the CCR. However, acute epithelial injury by enteric pathogens leads to an increase in EGF ligand expression in the CCR and rapid expansion of the GSSC lineage. Thus, the unique proliferative set points for gut stem cells residing in physiologically distinct compartments are governed by regional control of niche signals along the A/P axis.

Regional control of Drosophila gut stem cell proliferation: EGF establishes GSSC proliferative set point & controls emergence from quiescence.

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Marie Strand

Full Text Available Adult stem cells vary widely in their rates of proliferation. Some stem cells are constitutively active, while others divide only in response to injury. The mechanism controlling this differential proliferative set point is not well understood. The anterior-posterior (A/P axis of the adult Drosophila midgut has a segmental organization, displaying physiological compartmentalization and region-specific epithelia. These distinct midgut regions are maintained by defined stem cell populations with unique division schedules, providing an excellent experimental model with which to investigate this question. Here, we focus on the quiescent gastric stem cells (GSSCs of the acidic copper cell region (CCR, which exhibit the greatest period of latency between divisions of all characterized gut stem cells, to define the molecular basis of differential stem cell activity. Our molecular genetic analysis demonstrates that the mitogenic EGF signaling pathway is a limiting factor controlling GSSC proliferation. We find that under baseline conditions, when GSSCs are largely quiescent, the lowest levels of EGF ligands in the midgut are found in the CCR. However, acute epithelial injury by enteric pathogens leads to an increase in EGF ligand expression in the CCR and rapid expansion of the GSSC lineage. Thus, the unique proliferative set points for gut stem cells residing in physiologically distinct compartments are governed by regional control of niche signals along the A/P axis.

The theme revenge in the cinema: a literary philosophical approach

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Fábio José de Queiroz

2016-04-01

Full Text Available In this article, the focus is revenge, taking as a starting point two cinematographic works –Once upon a time in this article is revenge, taking as a starting point two cinematographic works­ once upon a time in West, by Sergio Leone, and also colors: White by Krzysztof Kieslowsk. Without the direct influence of a purely artistic appreciation of both movies, this is about a study of literary­ philosophical lineage by relying on classical seeks to provide an theoretical analyze of the theme, avoiding falling into an empiricist interpretation, trivial and shallow of the object.

Pupils' Knowledge and Spoken Literary Response beyond Polite Meaningless Words: Studying Yeats's "Easter, 1916"

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Gordon, John

2016-01-01

This article presents research exploring the knowledge pupils bring to texts introduced to them for literary study, how they share knowledge through talk, and how it is elicited by the teacher in the course of an English lesson. It sets classroom discussion in a context where new examination requirements diminish the relevance of social, cultural…

Imagination, creation and literary origins: dreaming and waking

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Catherine Farrar

2012-01-01

Full Text Available Quotation, allusion, mediumship and speaking with or through others’ voices is an established ad well-worked aspect of culture, indeed, it seems, across all cultures, an appropriate subject indeed for COMPASIO. So too has the inspiration artists have drawn for their creation from dreams and the voices of a world beyond themselves. This has been relatively well studied in such fields as visual art and music. Less attention, however, despite its clear centrality, has been given to literary creation. This paper, by a cultural anthropologist, uses a personal case study to illustrate how this can work through the interaction between dreams and narrative. The case here, though only singular in its detailed content and process has wider implications for the comparative anthropological and comparative study of culture, individuality, imagination and creativity.

Analytical Study of the Status of Myth in the Creation of Literary and Artistic Works

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Sedigheh Sherkat Moghaddam

2016-02-01

Full Text Available The prevalent question raised in literary theories has been the quiddity of literature. However, the question of “what is literature?” is a philosophical issue. On the other hand, the relationship between myth and literature has always been raised by most scholars and many have considered literature a subtype of myths. In this paper, while pointing transiently to the concepts and definitions of myth from the perspective of the great thinkers, with a different view, the role of myth in creation of artistic works is discussed. In this review, the critic attempts to interpret the literary work - or some sources in the text - to its prototype or archetype with its deep structure. With the help of this method, tracing the old or new mythology, distorted or worn, it is understood how they have passed over the whole cultural field and have found their specific formation. Keywords: Literature, Myth, Creation, Imagination, Démythologisation, Remythification, Gilbert Durand

The phenomenon of soccer in some literary texts: Classical and contemporary

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Victor Gil Castañeda

2009-11-01

Full Text Available This article talks about how in the literature history, many authors had shown a profound interest in describing the phenomenon of football soccer, one of the most popular sports on earth. We can see this aspect in pre-Hispanic texts like: Popol Vuh, also in some modern intellectuals like Eduardo Galeano (Uruguayan, in his book: El footboy a sol y sombra. The document also mentioned other literary texts which prominent figures, narrative atmospheres, sail in the aesthetic description of the football

Speech Act Theory and the Concept of Intention in Literary Criticism

OpenAIRE

García Landa, José Angel

2011-01-01

The aim of this paper is to trace the outline of a speech act theory of literature, taking into account the work of critics who react against the prevailing anti-intentionalist schools of criticism, such as the New Criticism, some versions of structuralism, and deconstruction. The intentionalist critics prepare the ground for a theory of literary discourse considered as a speech act, since it is known that the concept of intention is central to the analysis of speech acts. Such a theory of li...

Andalusia in Cervantes’ Novelas Ejemplares: a reflection in Cervantes’ literary space

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Antonio Rey Hazas

2009-12-01

Full Text Available The article analyses the interrelationship between life and literature which Cervantes’ Novelas Ejemplares —or to be more precise, some of them— bear as a hallmark of their artistic identity; a hallmark which in turn involves a certain view on Andalusia, and above all, on Seville; particularly, on a Seville which stands for both the object of and the inspiration to a peculiar novelistic view which is key for understanding some of these novels and the spatial literary perception we find in Cervantes’ oeuvre.

From Literary Classics to Twitter: Some Examples of Retelling

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Claudia Cao

2014-11-01

Full Text Available After having defined the “microliterature” among the digital textual forms and after a brief analysis of its origin, this paper gives an overview of the three main narrative forms risen from Twitter, with particular attention for the widespread phenomenon of retellings. The aim of this study is to examine the two more diffused typologies of serial retelling ‒ the collective and the authorial form ‒ throughout the concept of convergence theorized by Jenkins (2006. Finally, the last example taken into consideration ‒ Twitterature (Penguin 2009, sixty retellings of literary classics reproducing the Twitter texts ‒ testifies the circularity and reciprocity of the osmosis process between literature and new media.

The literary and philosophical conceptions of Laza Kostić

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Aleksić Slađana V.

2016-01-01

Full Text Available Laza Kostić, in the early seventies of the XIX century, opposed the utilitarianism of Nikolay Chernyshevsky and Svetozar Markovié, and advocated the idea of aestheticism in poetry and art. In his study about Jovan Jovanović Zmaj, Kostić had discovered two opposing processes in the poet, which he symbolically named the battle between the dragon and the nightingale. Kostić's conception about the origin of poetry is at the intersection of romanticist poetics about creation from divine inspiration, and a philosophical concept of the interference as a basic principle. The paper sheds light on the correspondence among the philosophical and literary views of Laza Kostić and his artistic work.

Checkmate: Linguistic and Literary Play in Salman Rushdie's "Haroun and the Sea of Stories"

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Bongartz, Christiane; Richey, Esther Gilman

2010-01-01

The authors use Noam Chomsky's theories about generative grammar to discuss the notion of linguistic creativity they believe lies at the core of storytelling as Salman Rushdie pictures it in his novel, "Haroun and the Sea of Stories." The production of meaning through the use of narrative helps explain the rules of the literary game,…

Arctigenin in combination with quercetin synergistically enhances the anti-proliferative effect in prostate cancer cells

Science.gov (United States)

Wang, Piwen; Phan, Tien; Gordon, David; Chung, Seyung; Henning, Susanne M.; Vadgama, Jaydutt V.

2014-01-01

Scope We investigated whether a combination of two promising chemopreventive agents arctigenin and quercetin increases the anti-carcinogenic potency at lower concentrations than necessary when used individually in prostate cancer. Methods and results Androgen-dependent LAPC-4 and LNCaP prostate cancer cells were treated with low doses of arctigenin and quercetin alone or in combination for 48h. The anti-proliferative activity of arctigenin was 10-20 fold stronger than quercetin in both cell lines. Their combination synergistically enhanced the anti-proliferative effect, with a stronger effect in androgen receptor (AR) wild-type LAPC-4 cells than in AR mutated LNCaP cells. Arctigenin demonstrated a strong ability to inhibit AR protein expression in LAPC-4 cells. The combination treatment significantly inhibited both AR and PI3K/Akt pathways compared to control. A protein array analysis revealed that the mixture targets multiple pathways particularly in LAPC-4 cells including Stat3 pathway. The mixture significantly inhibited the expression of several oncogenic microRNAs including miR-21, miR-19b, and miR-148a compared to control. The mixture also enhanced the inhibition of cell migration in both cell lines compared to individual compounds tested. Conclusion The combination of arctigenin and quercetin, that target similar pathways, at low physiological doses, provides a novel regimen with enhanced chemoprevention in prostate cancer. PMID:25380086

Émotions littéraires médiévales : une approche émotionologique / Medieval Literary Emotions: an Emotionological Approach

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Brînduşa Grigoriu

2014-11-01

Full Text Available Medieval Literary Emotions: an Emotionological Approach. Literary emotions can be an interesting field of research for historians and hermeneutists. Our study focuses on the possibility of investigating the most ancient text of French literature, La Cantilène de sainte Eulalie, with the instruments provided by the new paradigm of emotionology, which aims at exploring « the attitudes or standards that a society, or a definable group within a society, maintains toward basic emotions and their appropriate expression », as Peter N. and Carol Z. Stearns put it in their ambitious study of 1985. Although this epistemological branch is well represented in the English-speaking world, the approach has been but rarely practiced in the literary critique of French works. What we attempt to do in this paper is to test the explicative and descriptive power of such conceptual tools as “emotional styles”, “feeling rules”, “emotives” and “emotional communities” in the reading and interpretation of the narrative data provided by the 29 lines of the paraliturgical poem in Old French. The characters in the story can be relatively well individualized, like Eulalia and Maximian, or collectively relevant, like the pagan community that strives to convert the young virgin to idolatry. The most fascinating puzzle, in terms of emotionology, is provided by the God character, whose behavior is far from being simple or even cohesive : at first a witness to the scene of torture, He seems to get (emotionally? involved in a rescue mission, in order to keep Eulalia safe from the fire; this pyretic immunity is a strong emotive act, meant to enrage the king, who then decides to use the sword against her. At this point, this first French literary God (so to say seems to be “moved” by the prayer of his Christian servant, whom He allows to die beheaded. Of course, Eulalia’s soul sets an example of happy blessed ending, and rises to the sky in the shape of a

A. E. van Vogt's "Unreality" and Formula Writing.

Science.gov (United States)

Drake, H. L.

A. E. van Vogt's theory of "unreality" explains in part how he has become so prolific in a literary genre--science fiction/science fantasy--which only recently has experienced a rise in popularity. His theory states that the science fictional sentence must have in it something that requires a contribution from the reader. If the author…

Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discovery

DEFF Research Database (Denmark)

Poulsen, Michael; Oh, Dong-Chan; Clardy, Jon

2011-01-01

and solitary Hymenoptera. Here we test this possibility by examining two species of solitary mud dauber wasps, Sceliphron caementarium and Chalybion californicum. We performed enrichment isolations from 33 wasps and obtained more than 200 isolates of Streptomyces Actinobacteria. Chemical analyses of 15...... and antibacterial activity. The prevalence and anti-microbial properties of Actinobacteria associated with these two solitary wasp species suggest the potential role of these Streptomyces as antibiotic-producing symbionts, potentially helping defend their wasp hosts from pathogenic microbes. Finding...... phylogenetically diverse and chemically prolific Actinobacteria from solitary wasps suggests that insect-associated Actinobacteria can provide a valuable source of novel natural products of pharmaceutical interest....

Literary representations of death, dying and bereavement in children´s literature

OpenAIRE

Schroth, Klara Charlotte

2017-01-01

Death, dying and bereavement are universal human concerns and yet never fully compre-hensible or knowable. In order to find an approach to the topic, this paper examines and analyses literary representations of death, dying and bereavement in Anglophone literature for children. Scholars such as Kathryn James or Roberta Seelinger Trites have argued for a shift from objective and realistic representations in pre-1980 children’s novels towards an increasing use of narrative devices and fantastic...

M.Yu. Lermontov’s linguistic/literary personality through perspective of linguistic personality perception by philologist V.V. Vinogrado

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Larisa N. Kuznetsova

2011-04-01

Full Text Available The article considers M.Yu. Lermontov’s linguistic / literary personality through perspective of linguistic personality perception by Great Russian scientist-philologist and linguist, Academician V.V. Vinogradov.

Excerpt from Dead Stars: American and Philippine Literary Perspectives on the American Colonization of the Philippines

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Jennifer M. McMahon

2011-12-01

Full Text Available Dead Stars: American and Philippine Literary Perspectives on the American Colonization of the Philippines examines the American colonization of the Philippines from three distinct but related literary perspectives. The first is the reaction of anti-imperialist American writers Mark Twain, W. E. B. Du Bois, and William James to America’s first foray into the role of colonizer and how their varied essays, letters, and speeches provide an incisive delineation of fundamental conflicts in American identity at the turn of the twentieth century. The book then analyzes how these same conflicts surface in the colonial regime’s use of American literature as a tool to inculcate American values in the colonial educational system. Finally, Dead Stars considers the way three early and important Filipino writers—Paz Marquez Benitez, Maximo Kalaw, and Juan C. Laya—interpret and represent these same tensions in their fiction.

The Partisan Trajectory of the American Pro-Life Movement: How a Liberal Catholic Campaign Became a Conservative Evangelical Cause

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Daniel K. Williams

2015-04-01

Full Text Available This article employs a historical analysis of the religious composition of the pro-life movement to explain why the partisan identity of the movement shifted from the left to the right between the late 1960s and the 1980s. Many of the Catholics who formed the first anti-abortion organizations in the late 1960s were liberal Democrats who viewed their campaign to save the unborn as a rights-based movement that was fully in keeping with the principles of New Deal and Great Society liberalism, but when evangelical Protestants joined the movement in the late 1970s, they reframed the pro-life cause as a politically conservative campaign linked not to the ideology of human rights but to the politics of moral order and “family values.” This article explains why the Catholic effort to build a pro-life coalition of liberal Democrats failed after Roe v. Wade, why evangelicals became interested in the antiabortion movement, and why the evangelicals succeeded in their effort to rebrand the pro-life campaign as a conservative cause.

DNA Amplifications and Aneuploidy, High Proliferative Activity and Impaired Cell Cycle Control Characterize Breast Carcinomas with Poor Prognosis

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Harald Blegen

2003-01-01

Full Text Available In order to explore whether specific cytogenetic abnormalities can be used to stratify tumors with a distinctly different clinical course, we performed comparative genomic hybridization (CGH of tumors from patients who were diagnosed with metastatic disease after an interval of less than 2 years or who remained free from distant metastases for more than 10 years. All patients presented with distant metastases after mastectomy indicating that none of the patients in this study was cured and free of remaining tumor cells. Tumors in the group of short‐term survivors showed a higher average number of chromosomal copy alterations compared to the long‐term survivors. Of note, the number of sub‐chromosomal high‐level copy number increases (amplifications was significantly increased in the group of short‐term survivors. In both short‐ and long‐term survivors recurrent chromosomal gains were mapped to chromosomes 1q, 4q, 8q, and 5p. Copy number changes that were more frequent in the group of short‐term survivors included gains of chromosome 3q, 9p, 11p and 11q and loss of 17p. Our results indicate that low‐ and high grade malignant breast adenocarcinomas are characterized by a specific pattern of chromosomal copy number changes. Furthermore, immunohistochemical evaluation of the expression levels of Ki‐67, p27KIP1, p21WAF1, p53, cyclin A and cyclin E revealed a correlation between increased proliferative activity and poor outcome.

New Admissions to the K.G. Paustovsky Moscow Literary Museum-Center

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Angelica I. Dormidontova

2018-03-01

Full Text Available This is an overview of а new collection received by the K.G. Paustovsky Moscow Literary Museum-Center in 2017, the year of the 125th anniversary of his birth. The collection consists of 366 items. Among them are manuscripts, biographical documents, letters, books with autographs, photographs, posters, booklets, and drawings. These items are of considerable interest for the study of the writer’s methods, his biography as well as for understanding the circle of his contacts. The overview incorporates a number of authentic documents.