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Sample records for prolific literary activity

  1. Proliferative Activity and Neuroprotective Effect of Ligustrazene ...

    African Journals Online (AJOL)

    Proliferative Activity and Neuroprotective Effect of. Ligustrazene Derivative by Irritation of Vascular. Endothelial Growth Factor Expression in Middle Cerebral. Artery Occlusion Rats. Zhang Huazheng1, Wang Penglong2, Ren Liwei1, Wang Xiaobo2, Li Guoliang2,. Wang Mina1, Chu Fuhao2, Gong Yan2, Xu Bing2, Bi Siling1, ...

  2. Anti-proliferative activity of recombinant melittin expressed in ...

    African Journals Online (AJOL)

    Recombinant melittin was then successfully expressed in Escherichia coli. The activity of affinity-purified recombinant melittin was determined in human leukemic U937 cells. Results show that the recombinant melittin had the same anti-proliferative activity in human leukemic U937 cells in vitro as natural one. This shows the ...

  3. Antioxidant and Anti-proliferative Activities of Flavonoids from ...

    African Journals Online (AJOL)

    Purpose: To investigate the chemical composition of Bidens pilosa L. var. radiata. Sch Bip. (BP), as well as its antioxidant and anti-proliferative activities. Methods: The whole herb of BP was extracted with 95 % ethanol, which was then partitioned sequentially with petroleum ether, ethyl acetate and n-butyl alcohol to obtain ...

  4. Proliferative activity of stomach cancer and assessment of individual radiosensitivity

    International Nuclear Information System (INIS)

    Chissov, V.I.; Sergeeva, N.S.; Dar'yalova, S.L.; Petrov, A.N.; Repina, A.G.; Belous, T.A.; Pelevina, I.I.

    1991-01-01

    An indirect immunofluorescent method with polyclonal antibodies to thymidine was used to assess the proliferative activity (PA-percent of cells in the S-phase of the cell cycle) of 79 stomach tumors from primary cancer patients. Stomach cancer PA was shown to vary from 0.1 to 69.7%. Stomach cancer PA did not depend either on a tumor size or a degree of the involvement of regional lymph nodes. The mean PA of well-differentiated adenocarcinoma was slightly lower (14.9±4.7%) than that of low differentiated ones. Of 79 patients a tumor process was interpreted as a resectable one in 62. They were given preoperative irradiation at a total focal dose of 36 Gy followed by operation. It was shown that tumor radioresistance could be predicted in unchanged PA indices of their increase at the beginning of a course of irradiation with the probability of 95%

  5. NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy.

    Science.gov (United States)

    Loukovaara, Sirpa; Piippo, Niina; Kinnunen, Kati; Hytti, Maria; Kaarniranta, Kai; Kauppinen, Anu

    2017-12-01

    Innate immunity and dysregulation of inflammatory processes play a role in vascular diseases like atherosclerosis or diabetes. Nucleotide-binding domain and Leucine-rich repeat Receptor containing a Pyrin domain 3 (NLRP3) inflammasomes are pro-inflammatory signalling complexes that were found in 2002. In addition to pathogens and other extracellular threats, they can be activated by various endogenous danger signals. The purpose of this study was to find out whether NLRP3 activation occurs in patients with sight-threatening forms of diabetic retinopathy (DR). Inflammasome components NLRP3 and caspase-1, inflammasome-related pro-inflammatory cytokines IL-1β and IL-18, vascular endothelial growth factor (VEGF), acute-phase cytokines TNF-α and IL-6, as well as adaptive immunity-related cytokine interferon gamma (IFN-γ) were measured from the vitreous samples of 15 non-proliferative diabetic retinopathy (non-PDR) and 23 proliferative diabetic retinopathy (PDR) patients using the enzyme-linked immunosorbent assay (ELISA) method. The adaptor protein apoptosis-associated speck-like protein containing a CARD (ASC) was determined using the Western blot technique. Inflammasome components were present in the vitreous of DR patients. Along with VEGF, the levels of caspase-1 and IL-18 were significantly increased, especially in PDR eyes. Interestingly, clearly higher levels of NLRP3 were found in the PDR eyes with tractional retinal detachment (TRD) than from PDR eyes with fully attached retina. There were no significant differences in the amounts of IL-1β, TNF-α, IL-6, and IFN-γ that were detectable in the vitreous of both non-PDR and PDR patients. Our results suggest that NLRP3 inflammasome activation can be associated especially with the pathogenesis of PDR. The lack of differences in TNF-α, IL-6, and IFN-γ also alludes that acute inflammation or T-cell-mediated responses do not dominate in PDR pathogenesis. © 2017 Acta Ophthalmologica Scandinavica Foundation

  6. Nonconformist discourse of literary criticism activity of Mykhailyna Kotsiubynska

    Directory of Open Access Journals (Sweden)

    Светлана Григорьевна Бугай

    2015-05-01

    Full Text Available The peculiarity of scientific and critical reception of history and theory of Ukrainian literature in studios of Mykhaylyna Kotsiubynska is considered in the article. It is given the detailed analysis of scientific approaches and attitudes in literary interpretation of the key issues of artistic discourse: features of genre-thematic, compositional structure, imagery and stylistic palette of writing, specific of writer’s artistic thinking, ethical and philosophical foundations of creativity, originality of associative relationships, understanding artistic heritage in the context of the time

  7. Proliferative activity as a prognostic factor of a human tumor radiation reactions

    International Nuclear Information System (INIS)

    Karakulov, R.K.; Pelevina, I.I.

    1986-01-01

    The following questions are considered: 1) whether cell proliferation initial parameters can serve for predicting the tumor radial reaction; 2) whether proliferative activity change can be a criterion for estimating the treatment efficiency; 3) acquisition of data on biological peculiarities of different types of tumors. Connection between proliferative activity drop and clinical reaction under tumor radiotherapy is ascertained

  8. Correlation between proliferative activity and cellular thickness of human mesenchymal stem cells

    International Nuclear Information System (INIS)

    Katsube, Yoshihiro; Hirose, Motohiro; Nakamura, Chikashi; Ohgushi, Hajime

    2008-01-01

    A cell's shape is known to be related to its proliferative activity. In particular, large and flat mammalian adult stem cells seem to show slow proliferation, however using quantitative analysis to prove the phenomenon is difficult. We measured the proliferation and cellular thickness of human mesenchymal stem cells (MSCs) by atomic force microscopy and found that MSCs with high proliferative activity were thick while those with low proliferative activity were thin, even though these MSCs were early passage cells. Further, low proliferative MSCs contained many senescence-associated β-galactosidase positive cells together with high senescence-associated gene expression. These findings suggest that the measurement of cellular thickness is useful for estimating the proliferative activity of human MSCs and is expected to be a practical tool for MSC applications in regenerative medicine

  9. Proliferative activity in oral pyogenic granuloma: A comparative immunohistochemical study

    Directory of Open Access Journals (Sweden)

    Rezvani Gita

    2010-07-01

    Full Text Available Context: Pyogenic granuloma (PG is one of the most common reactive vascular lesions in the oral mucosa, which has been divided into the lobular capillary hemangioma (LCH and the non lobular type (non-LCH as two distinct entities, on the basis of some investigations. Aims: This study aims to compare the proliferative and angiogenic activity of two histological types of PG to determine whether they have two distinct types of biological behavior. Settings and Design: In this retrospective cross-sectional study, immunostaining was performed on 10 cases of each type of PG. Materials and Methods: About 4μm sections were cut from formalin-fixed paraffin-embedded blocks and each specimen was stained with both anti-CD31 and anti-Ki-67 antibodies simultaneously. Labeling index (LI was determined for both types by counting Ki-67 and CD31 positive cells separately and simultaneously in 1000 stromal and luminal cells. Micro vessel count (MVC, the mean number of micro vessels in five areas at Χ200 magnification, was also determined for both groups. Statistical Analysis: The results were statistically compared using the Mann-Whitney U-test. Results: Ki-67 LI in LCH (5.4 ± 2.4 was higher than non-LCH (3.9 ± 3.9. The percentage of CD31 positive cells in LCH (28.5 ± 22 was lower than non-LCH (37.1 ± 20.8 and simultaneously immunostaining for both markers in LCH type (2.4 ± 2.1 was higher than non-LCH (1.2 ± 1. The MVC was approximately 77.35 ± 34.6 and 82.6 ± 42.7 in the lobular areas of LCH and central areas of non-LCH PG, respectively. These differences were not statistically significant. Conclusions: These results demonstrate a higher proliferation activity in endothelial cells of LCH PG than in non-LCH.

  10. Epithelial cell proliferative activity of Barrett's esophagus : methodology and correlation with traditional cancer risk markers

    NARCIS (Netherlands)

    Peters, FTM; Ganesh, S; Kuipers, EJ; De Jager-Krikken, A; Karrenbeld, A; Harms, Geert; Sluiter, WJ; Koudstaal, J; Klinkenberg-Knol, EC; Lamers, CBHW; Kleibeuker, JH

    Barrett's esophagus (BE) is a premalignant condition, due to chronic gastroesophageal reflux. Effective antireflux therapy may diminish cancer risk. To evaluate this option an intermediate marker is needed. We developed a methodology for measurement of epithelial cell proliferative activity of

  11. Effect of С(60 fullerene on metabolic and proliferative activity of PKE cell line

    Directory of Open Access Journals (Sweden)

    I. V. Belochkina

    2014-04-01

    Full Text Available The effect of С60 fullerene aqueous colloid solution (C60FAS on activity of redox and proliferative processes in PKE (transplantable cell line of pig kidney embryo cells has been studied. In particular, it was established that the presence of С60 fullerene (127 μМ in culturing medium of PKE cells during 48 h did not change their ability to reduce non-toxic АlamarBlue redox indicator and proliferative acti­vity.

  12. Determinants of physical activity in university students: a literary review

    Directory of Open Access Journals (Sweden)

    Ana Isabel Caro-Freile

    2017-05-01

    Full Text Available Physical activity refers to the body movement that generates energy expenditure, its frequent practice improves physical and mental functions; Active transportation, daily activities and recreation correspond to the most common form of physical activity. In Colombia the majority of the population is inactive, children are more active, but this condition decreases with age, the percentage of college students who engage in physical activity is low, this practice is conditioned by internal motivation, physical condition, Availability of time and social support. The taste for sports, the competitive spirit, the improvement of the corporal image, the management of the stress and the benefits for the health are motivating factors for the practice of the physical activity in university students; On the other hand, laziness, fear of injury, lack of sports scenarios and insecurity of the environment are the most frequent barriers to physical activity in this population

  13. [A correlation between diffusion kurtosis imaging and the proliferative activity of brain glioma].

    Science.gov (United States)

    Tonoyan, A S; Pronin, I N; Pitshelauri, D I; Shishkina, L V; Fadeeva, L M; Pogosbekyan, E L; Zakharova, N E; Shults, E I; Khachanova, N V; Kornienko, V N; Potapov, A A

    2015-01-01

    The aim of the study was to assess the capabilities of diffusion kurtosis imaging (DKI) in diagnosis of the glioma proliferative activity and to evaluate a relationship between the glioma proliferative activity index and diffusion parameters of the contralateral normal appearing white matter (CNAWM). The study included 47 patients with newly diagnosed brain gliomas (23 low grade, 13 grade III, and 11 grade IV gliomas). We determined a relationship between absolute and normalized parameters of the diffusion tensor (mean (MD), axial (AD), and radial (RD) diffusivities; fractional (FA) and relative (RA) anisotropies) and diffusion kurtosis (mean (MK), axial (AK), and radial (RK) kurtosis; kurtosis anisotropy (KA)) and the proliferative activity index in the most malignant glioma parts (pAK, and RK) and anisotropy (KA, FA, RA) values increased, and diffusivity (MD, AD, RD) values decreased as the glioma proliferative activity index increased. A strong correlation between the proliferative activity index and absolute RK (r=0,71; p=0.000001) and normalized values of MK (r=0.8; p=0.000001), AK (r=0.71; p=0.000001), RK (r=0.81; p=0.000001), and RD (r=-0.71; p=0.000001) was found. A weak, but statistically significant correlation between the glioma proliferative activity index and diffusion values RK (r=-0.36; p=0.014), KA (r=-0.39; p=0.007), RD (r=0.35; p=0.017), FA (r=-0.42; p=0.003), and RA (r=-0.41; p=0.004) of CNAWM was found. DKI has good capabilities to detect immunohistochemical changes in gliomas. DKI demonstrated a high sensitivity in detection of microstructural changes in the contralateral normal appearing white matter in patients with brain gliomas.

  14. Analysis of in situ proliferative activity in oral gingival epithelium in patients with xerostomia.

    Science.gov (United States)

    Celenligil-Nazliel, Haviye; Palali, Ali; Ayhan, Ayşe; Ruacan, Sevket

    2003-02-01

    Sjögren's syndrome is an autoimmune disease characterized by xerostomia and keratoconjunctivitis sicca. The relationship between xero-stomia and proliferative activity in human gingival epithelium is not known. Proliferating cell nuclear antigen (PCNA) is a nuclear protein associated with the cell cycle. Nuclear PCNA immunoreactivity is found in the proliferative compartment of normal tissues. The aims of this study were to evaluate PCNA expression in oral gingival epithelium of healthy and inflamed gingiva obtained from patients with Sjögren's syndrome, and to compare the results to age- and gender-matched subjects with normal salivary function. Eighteen Sjögren's syndrome patients and 28 controls (14 with chronic periodontitis and 14 with no clinical evidence of periodontal disease) were included in the study. Biopsies were obtained from both inflamed and healthy gingiva. The expression of PCNA was evaluated in formalin-fixed, paraffin-embedded gingival samples using an immunoperoxidase technique and PC10 monoclonal antibody to PCNA. PCNA expression was observed both in the basal and suprabasal layers, and was found to be more prominent in the suprabasal layers. Proliferative index (PI) in inflamed gingiva was significantly lower in the Sjögren's syndrome group. However, no significant difference was observed between the study and control groups with respect to PI in healthy gingiva. In both groups, PI was found to be increased due to inflammation. Our data indicate that proliferative activity is observed in the suprabasal layers and, less frequently, in the basal layer. Inflammation caused increased proliferative activity. However, this positive effect of inflammation on epithelial cell proliferation decreased significantly with a lack of saliva. Therefore, it appears that saliva-derived biological mediators may also contribute to increased proliferative activity observed during inflammation.

  15. Anti-proliferative activity of recombinant melittin expressed in ...

    African Journals Online (AJOL)

    kesiena

    2012-02-09

    Feb 9, 2012 ... 44 amino acid residues mediated by dipeptidylpeptidase. IV (Vlasak et al., 1983). It has been reported that the melittin exhibits antimicrobial activity and pro- ... Construction of recombinant expression vector. A pair of complementary oligonucleotides named Mel-1 (5′-GAT. CCG GAA TTG GAG CAG TTC ...

  16. Proliferative and antioxidant activity of Symphytum officinale root extract.

    Science.gov (United States)

    Sowa, Ireneusz; Paduch, Roman; Strzemski, Maciej; Zielińska, Sylwia; Rydzik-Strzemska, Ewelina; Sawicki, Jan; Kocjan, Ryszard; Polkowski, Janusz; Matkowski, Adam; Latalski, Michał; Wójciak-Kosior, Magdalena

    2018-03-01

    The root of Symphytum officinale L. is commonly used in folk medicine to promote the wound healing, reduce the inflammation and in the treatment of broken bones. The objective of our investigation was to analyse the extract from S. officinale in term of its antioxidant activity and the effect on cell viability and proliferation of human skin fibroblast (HSF). Moreover, the quantification of main phenolics and allantoin was conducted using HPLC-DAD method. Five compounds were found: rosmarinic, p-hydroxybenzoic, caffeic, chlorogenic and p-coumaric acid. DPPH, FRAP and TPC assay showed the high antioxidant activity of the extract. MTT test proved the stimulatory effect on cell metabolism and viability of HSF cells. Moreover, no changes in cytoskeleton structure and cells shape were observed. The obtained results indicate that non-toxic extract from S. officinale root has strong antioxidant potential and a beneficial effect on human skin fibroblasts.

  17. Effect of postradiation bleeding on proliferative activity of cells in small intestine crypts of rats

    Energy Technology Data Exchange (ETDEWEB)

    Petrovic, N V [Institut za Nuklearne Nauke Boris Kidric, Vinca (Yugoslavia)

    1975-12-01

    The effect of postradiation bleeding on the dynamics of duodenal crypt's cell proliferation in rats was studied. The animals, females, three months old, weighing 170 or 180 g, were exposed to radiation of 800 R (115 R/min) and immediately after irradiation were bled by cardiac puncture to 50% of total blood volume. Proliferative activity of duodenal epithelium cells was monitored for a period of five days after irradiation. For control purposes normal, irradiated and only bled animals were used. The results demonstrated that although there are no significant differences in proliferative activity of duodenal epithelium cells in irradiated and bled animals and only irradiated animals, the postradiation reparative processes in irradiated and bled animals is considerably more stable. It is considered that bleeding itself by its hypoxic activity reduced the sensitivity of epithelium to the dose of radiation used. On the other hand, bleeding removed the damaging agents which appear after total body irradiation.

  18. Reading a suspenseful literary text activates brain areas related to social cognition and predictive inference.

    Directory of Open Access Journals (Sweden)

    Moritz Lehne

    Full Text Available Stories can elicit powerful emotions. A key emotional response to narrative plots (e.g., novels, movies, etc. is suspense. Suspense appears to build on basic aspects of human cognition such as processes of expectation, anticipation, and prediction. However, the neural processes underlying emotional experiences of suspense have not been previously investigated. We acquired functional magnetic resonance imaging (fMRI data while participants read a suspenseful literary text (E.T.A. Hoffmann's "The Sandman" subdivided into short text passages. Individual ratings of experienced suspense obtained after each text passage were found to be related to activation in the medial frontal cortex, bilateral frontal regions (along the inferior frontal sulcus, lateral premotor cortex, as well as posterior temporal and temporo-parietal areas. The results indicate that the emotional experience of suspense depends on brain areas associated with social cognition and predictive inference.

  19. Proliferative activity and branching morphogenesis in the human prostate: a closer look at pre- and postnatal prostate growth

    NARCIS (Netherlands)

    Xue, Y.; Sonke, G.; Schoots, C.; Schalken, J.; Verhofstad, A.; de la Rosette, J.; Smedts, F.

    2001-01-01

    To gain further insight into the molecular cell biologic features of prostate development, we investigated the proliferative activity of prostate epithelial and stromal cells and their topographic relationship with neuroendocrine (NE) cell distribution and regional heterogeneity. Consecutive

  20. Proliferative activity and branching morphogenesis in the human prostate: a closer look at pre- and postnatal prostate growth.

    NARCIS (Netherlands)

    Xue, Y.; Sonke, G.S.; Schoots, C.; Schalken, J.A.; Verhofstad, A.A.J.; Rosette, J.J.M.H.C. de la; Smedts, F.

    2001-01-01

    BACKGROUND: To gain further insight into the molecular cell biologic features of prostate development, we investigated the proliferative activity of prostate epithelial and stromal cells and their topographic relationship with neuroendocrine (NE) cell distribution and regional heterogeneity.

  1. Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa

    Science.gov (United States)

    Yue, Grace G. L.; Chan, Ben C. L.; Hon, Po-Ming; Lee, Mavis Y. H.; Fung, Kwok-Pui; Leung, Ping-Chung; Lau, Clara B. S.

    2010-01-01

    The rhizome of Curcuma longa (CL) has been commonly used in Asia as a potential candidate for the treatment of different diseases, including inflammatory disorders and cancers. The present study evaluated the anti-proliferative activities of the isolated compounds (3 curcuminoids and 2 turmerones) from CL, using human cancer cell lines HepG2, MCF-7 and MDA-MB-231. The immunomodulatory activities of turmerones (α and aromatic) isolated from CL were also examined using human peripheral blood mononuclear cells (PBMC). Our results showed that the curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) and α-turmerone significantly inhibited proliferation of cancer cells in dose-dependent manner. The IC50 values of these compounds in cancer cells ranged from 11.0–41.8 μg/ml. Alpha-turmerone induced MDA-MB-231 cells to undergo apoptosis, which was confirmed by annexin-V & propidium iodide staining, and DNA fragmentation assay. The caspase cascade was activated as shown by a significant decrease of procaspases-3, -8 and -9 in α-turmerone treated cells. Both α-turmerone and aromatic-turmerone showed stimulatory effects on PBMC proliferation and cytokine production. The anti-proliferative effect of α-turmerone and immunomodulatory activities of ar-turmerone were shown for the first time. The findings revealed the potential use of CL crude extract (containing curcuminoids and volatile oil including turmerones) as chemopreventive agent. PMID:20438793

  2. Hyper-activation of Notch3 amplifies the proliferative potential of rhabdomyosarcoma cells.

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    Maria De Salvo

    Full Text Available Rhabdomyosarcoma (RMS is a pediatric myogenic-derived soft tissue sarcoma that includes two major histopathological subtypes: embryonal and alveolar. The majority of alveolar RMS expresses PAX3-FOXO1 fusion oncoprotein, associated with the worst prognosis. RMS cells show myogenic markers expression but are unable to terminally differentiate. The Notch signaling pathway is a master player during myogenesis, with Notch1 activation sustaining myoblast expansion and Notch3 activation inhibiting myoblast fusion and differentiation. Accordingly, Notch1 signaling is up-regulated and activated in embryonal RMS samples and supports the proliferation of tumor cells. However, it is unable to control their differentiation properties. We previously reported that Notch3 is activated in RMS cell lines, of both alveolar and embryonal subtype, and acts by inhibiting differentiation. Moreover, Notch3 depletion reduces PAX3-FOXO1 alveolar RMS tumor growth in vivo. However, whether Notch3 activation also sustains the proliferation of RMS cells remained unclear. To address this question, we forced the expression of the activated form of Notch3, Notch3IC, in the RH30 and RH41 PAX3-FOXO1-positive alveolar and in the RD embryonal RMS cell lines and studied the proliferation of these cells. We show that, in all three cell lines tested, Notch3IC over-expression stimulates in vitro cell proliferation and prevents the effects of pharmacological Notch inhibition. Furthermore, Notch3IC further increases RH30 cell growth in vivo. Interestingly, knockdown of Notch canonical ligands JAG1 or DLL1 in RMS cell lines decreases Notch3 activity and reduces cell proliferation. Finally, the expression of Notch3IC and its target gene HES1 correlates with that of the proliferative marker Ki67 in a small cohort of primary PAX-FOXO1 alveolar RMS samples. These results strongly suggest that high levels of Notch3 activation increase the proliferative potential of RMS cells.

  3. Synthesis, characterization, in vitro anti-proliferative and hemolytic activity of hydroxyapatite

    Science.gov (United States)

    Palanivelu, R.; Ruban Kumar, A.

    2014-06-01

    Hydroxyapatite (Ca10(PO4)6(OH)2, HAP) nanoparticles are widely used in several biomedical applications due to its compositional similarities to bone mineral, excellent biocompatibility and bioactivity, osteoconductivity. In this present investigation, HAP nanoparticles synthesized by precipitation technique using calcium nitrate and di-ammonium phosphate. The crystalline nature and the functional group analysis are confirmed using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and Fourier transform Raman spectroscopy (FT-Raman) respectively. The morphological observations are ascertained from field emission electron scanning electron microscope (FE-SEM) and transmission electron microscope (TEM). In vitro anti-proliferative and hemolytic activities are carried out on the synthesized HAP samples and the studies reveals that HAP have mild activity against erythrocytes.

  4. ROLE OF THE MORPHOMETRIC PARAMETERS OF INTRATUMORAL MICROVESSELS AND THE PROLIFERATIVE ACTIVITY OF TUMOR CELLS IN RENAL CELL CARCINOMA

    Directory of Open Access Journals (Sweden)

    N. A. Gorban

    2014-08-01

    Full Text Available Tumor cell proliferation and angiogenesis are essential factors for tumor growth, progression, and metastasis.Objective: to assess the relationship between the values of proliferative activity and the morphometric parameters of intratumoral microvessels in metastatic and localized carcinomas of the kidney.Materials and methods. Surgical specimens taken from 54 patients (32 men and 22 women aged 26 to 69 years (mean age 55 ± 1.5 years with the verified diagnosis of clear-cell renal cell carcinoma (RCC were studied.Conclusion. Proliferative activity and angioarchitectonics are an important biological characteristic of a tumor of unequal clinical value in RCC. Metastatic carcinoma has a higher proliferative activity and a low tumor vascularization than those of localized carcinoma.

  5. Synthesis, characterization and anti-proliferative activity of heterocyclic hypervalent organoantimony compounds.

    Science.gov (United States)

    Chen, Yi; Yu, Kun; Tan, Nian-Yuan; Qiu, Ren-Hua; Liu, Wei; Luo, Ning-Lin; Tong, Le; Au, Chak-Tong; Luo, Zi-Qiang; Yin, Shuang-Feng

    2014-05-22

    Three heterocyclic hypervalent organoantimony chlorides RN(CH2C6H4)2SbCl (2a R = t-Bu, 2b R = Cy, 2c R = Ph) and their chalcogenide derivatives [RN(CH2C6H4)2Sb]2O (3a R = t-Bu, 3b R = Cy, 3c R = Ph) were synthesized and characterized by techniques such as (1)H NMR, (13)C NMR, X-ray diffraction, and elemental analysis. It is found that the anti-proliferative activity detected over these compounds can be attributed to the coordination bond between the antimony and nitrogen atoms of these compounds. Moreover, a preliminary study on mechanistic action suggests that the inhibition effect is ascribable to cell cycle arrest and cell apoptosis. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  6. PECULIARITIES OF PROLIFERATIVE ACTIVITY OF CERVICAL SQUAMOUS CANCER IN HIV INFECTION.

    Science.gov (United States)

    Lytvynenko, M; Shkolnikov, V; Bocharova, T; Sychova, L; Gargin, V

    2017-09-01

    Patients with human immunodeficiency virus (HIV) infection have a statistically significant increased risk of developing cervical cancer. The expression of the human Ki-67 protein is strictly associated with cell proliferation. The purpose of our work was detection of proliferative activity in cervical squamous cancer in women with HIV infection. We investigated 24 cases (12 patients with HIV and 12 patients without HIV infection) of cervical carcinoma, where biopsy had been performed before the treatment. According to histopathological diagnoses, well-differentiated, moderately and poorly differentiated squamous cell carcinoma (7, 13 and 4 cases respectively) was determined. Mean age of women in the group with HIV infection was 32.7 years, and 38.2 years in the group without HIV infection. Detection of protein Ki-67 expression was performed with nuclear staining in the intermediate and superficial cells. The results of this work show that proliferative activity of cervical squamous cancer in women with HIV infection is characterized by a higher level of Ki-67 with averaging level for all histological types of squamous cell carcinoma 62.5±5.6% that is one and half times higher than in group without HIV infection. Depending on a histological type, expression of Ki-67 has increased from 4.7±3.8% in well-differentiated squamous cell carcinoma up to 89.2±5.1% in poorly differentiated squamous cell carcinoma for group with HIV, and from 21.3±2.4% to 79.4±3.7 in group without HIV.

  7. In vitro anti-proliferative activity of clove extract on human gastric carcinoma

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    A. Karimi

    2017-10-01

    Full Text Available Background and objectives: Cancer cell resistance to common chemotherapy agents is on rise. Plants are considered valuable sources of herbal drugs for cancer therapy. The present study was conducted to investigate the in vitro antioxidant, anti-proliferative, and apoptosis-inducing properties of clove (Syzygium aromaticum L. extract in human gastric carcinoma (AGS. Methods: Crude ethanol extract of S. aromaticum dried buds was prepared and  in vitro anti-proliferative effects of the extract on AGS and normal Human dermal fibroblasts (HDF cell lines were studied by MTT assay. To examine apoptosis induction, AGS cells were incubated with IC50 concentrations of the extract, stained with propidium iodide (PI and annexin V-fluorescein isothiocyanate (FITC, and analyzed by flow cytometry. Antioxidant activity and total phenolics and flavonoids contents were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH assay, Folin-Ciocalteu method, and aluminum chloride colorimetric method, respectively. Results: The IC50 of DPPH and total phenolics and flavonoids contents of the extract were 10.05±1.93 μg/mL, 225.6±40 mg GAE/g, and 29.30±2.35 mgRUT/g, respectively. The IC50 of the extract against HDFs was 649 µg/mL, higher than AGS cells, which was 118.7 g/mL at 48 h after treatment. Flow cytometric analysis showed that the extract induced cell apoptosis. Conclusions: Crude ethanol S. aromaticum extract had high total phenolics content, and suppressed the proliferation of human gastric cancer cells, likely due to apoptosis induction. Further studies should be conducted to determine the mechanisms of its anticancer effects.

  8. Calcium/calmodulin-dependent protein kinase II activity regulates the proliferative potential of growth plate chondrocytes.

    Science.gov (United States)

    Li, Yuwei; Ahrens, Molly J; Wu, Amy; Liu, Jennifer; Dudley, Andrew T

    2011-01-01

    For tissues that develop throughout embryogenesis and into postnatal life, the generation of differentiated cells to promote tissue growth is at odds with the requirement to maintain the stem cell/progenitor cell population to preserve future growth potential. In the growth plate cartilage, this balance is achieved in part by establishing a proliferative phase that amplifies the number of progenitor cells prior to terminal differentiation into hypertrophic chondrocytes. Here, we show that endogenous calcium/calmodulin-dependent protein kinase II (CamkII, also known as Camk2) activity is upregulated prior to hypertrophy and that loss of CamkII function substantially blocks the transition from proliferation to hypertrophy. Wnt signaling and Pthrp-induced phosphatase activity negatively regulate CamkII activity. Release of this repression results in activation of multiple effector pathways, including Runx2- and β-catenin-dependent pathways. We present an integrated model for the regulation of proliferation potential by CamkII activity that has important implications for studies of growth control and adult progenitor/stem cell populations.

  9. Roles of tissue plasminogen activator and its inhibitor in proliferative diabetic retinopathy

    Institute of Scientific and Technical Information of China (English)

    Shu-Ling; Wu; Dong-Mei; Zhan; Shu-Hong; Xi; Xiang-Lian; He

    2014-01-01

    AIM:To investigate the role of tissue plasminogen activator(t-PA) and plasminogen activator inhibitor(PAI)in proliferative diabetic retinopathy(PDR) and to discuss the correlations among t-PA, PAI and vascular endothelial growth factor(VEGF) expressions.METHODS:A total of 36 vitreous samples were collected from 36 patients with PDR(PDR group), and 17 vitreous samples from 17 patients with idiopathic macular hole were used as control. The concentrations of t-PA, PAI and VEGF in samples were determined by ELISA method. The correlations among t-PA, PAI and VEGF expressions were discussed.RESULTS:The concentrations of t-PA, PAI and VEGF in the PDR group were significantly higher than those in the control group(P <0.001). The t-PA and PAI expressions were highly correlated with the VEGF expression(P <0.001).CONCLUSION:In addition to VEGF, a variety of bioactive substances, such as t-PA and PAI, are involved in the pathogenesis involved in the angiogenesis of PDR.VEGF can activate t-PA expression, resulting in collagen tissue degradation and angiogenesis. VEGF may also activate the mechanism for endogenous anti-neovascularization.

  10. Cytological Study of Breast Carcinoma Before and After Oncotherapy with Special Reference to Morphometry and Proliferative Activity.

    Science.gov (United States)

    Koley, Sananda; Chakrabarti, Srabani; Pathak, Swapan; Manna, Asim Kumar; Basu, Siddhartha

    2015-12-01

    Our study was done to assess the cytological changes due to oncotherapy in breast carcinoma especially on morphometry and proliferative activity. Cytological aspirates were collected from a total of 32 cases of invasive ductal carcinoma both before and after oncotherapy. Morphometry was done on the stained cytological smears to assess the different morphological parameters of cell dimension by using the ocular morphometer and the software AutoCAD 2007. Staining was done with Ki-67 and proliferating cell nuclear antigen (PCNA) as proliferative markers. Different morphological parameters were compared before and after oncotherapy by unpaired Student's t test. Statistically significant differences were found in morphometric parameters, e.g., mean nuclear diameter, mean nuclear area, mean cell diameter, and mean cell area, and in the expression of proliferative markers (Ki-67 and PCNA). Statistical analysis was done by obtaining p values. There are statistically significant differences between morphological parameter of breast carcinoma cells before and after oncotherapy.

  11. Proliferative effects of apical, but not basal, matrix metalloproteinase-7 activity in polarized MDCK cells

    International Nuclear Information System (INIS)

    Harrell, Permila C.; McCawley, Lisa J.; Fingleton, Barbara; McIntyre, J. Oliver; Matrisian, Lynn M.

    2005-01-01

    Matrix metalloproteinase-7 (MMP-7) is primarily expressed in glandular epithelium. Therefore, its mechanism of action may be influenced by its regulated vectorial release to either the apical and/or basolateral compartments, where it would act on its various substrates. To gain a better understanding of where MMP-7 is released in polarized epithelium, we have analyzed its pattern of secretion in polarized MDCK cells expressing stably transfected human MMP-7 (MDCK-MMP-7), and HCA-7 and Caco2 human colon cancer cell lines. In all cell lines, latent MMP-7 was secreted to both cellular compartments, but was 1.5- to 3-fold more abundant in the basolateral compartment as compared to the apical. However, studies in the MDCK system demonstrated that MMP-7 activity was 2-fold greater in the apical compartment of MDCK-MMP-7 HIGH -polarized monolayers, which suggests the apical co-release of an MMP-7 activator. In functional assays, MMP-7 over-expression increased cell saturation density as a result of increased cell proliferation with no effect on apoptosis. Apical MMP-7 activity was shown to be responsible for the proliferative effect, which occurred, as demonstrated by media transfer experiments, through cleavage of an apical substrate and not through the generation of a soluble factor. Taken together, our findings demonstrate the importance of MMP-7 secretion in relation to its mechanism of action when expressed in a polarized epithelium

  12. Evaluation of viability and proliferative activity of human urothelial cells cultured onto xenogenic tissue-engineered extracellular matrices.

    LENUS (Irish Health Repository)

    Davis, Niall F

    2011-04-01

    To evaluate the viability and proliferative activity of human urothelial cells (HUCs) cultured on tissue-engineered extracellular matrix scaffolds and to assess the potential of extracellular matrixes to support the growth of HUCs in their expected in vivo urine environment.

  13. Effect of Enterococcus faecium EF 55 on morphometry and proliferative activity of intestinal mucosa in broilers infected with Salmonella Enteritidis

    Directory of Open Access Journals (Sweden)

    Ševčíková Zuzana

    2016-09-01

    Full Text Available Introduction: The present study aimed to investigate the effect of Enterococcus faecium EF55 on chickens, as well as its influence on proliferative activity of epithelial intestinal cells after infection with Salmonella enterica serovar Enteritidis phage type 4 (SE PT4. Moreover, the length and area of duodenal and jejunal villi of the birds were examined.

  14. Professional training in creative writing is associated with enhanced fronto-striatal activity in a literary text continuation task.

    Science.gov (United States)

    Erhard, K; Kessler, F; Neumann, N; Ortheil, H-J; Lotze, M

    2014-10-15

    The aim of the present study was to explore brain activities associated with creativity and expertise in literary writing. Using functional magnetic resonance imaging (fMRI), we applied a real-life neuroscientific setting that consisted of different writing phases (brainstorming and creative writing; reading and copying as control conditions) to well-selected expert writers and to an inexperienced control group. During creative writing, experts showed cerebral activation in a predominantly left-hemispheric fronto-parieto-temporal network. When compared to inexperienced writers, experts showed increased left caudate nucleus and left dorsolateral and superior medial prefrontal cortex activation. In contrast, less experienced participants recruited increasingly bilateral visual areas. During creative writing activation in the right cuneus showed positive association with the creativity index in expert writers. High experience in creative writing seems to be associated with a network of prefrontal (mPFC and DLPFC) and basal ganglia (caudate) activation. In addition, our findings suggest that high verbal creativity specific to literary writing increases activation in the right cuneus associated with increased resources obtained for reading processes. Copyright © 2014 Elsevier Inc. All rights reserved.

  15. Nuclear Morphometry in Ductal Breast Carcinoma with Correlation to Cell Proliferative Activity and Prognosis

    International Nuclear Information System (INIS)

    Radwan, M.M.; Amer, K.A.; Mokhtar, N.M.

    2003-01-01

    Morphometry is the quantitative description of biologic structures. This study was designed to evaluate the efficiency of morphometric measurements in diagnosis and prognosis of patients with breast carcinoma. Methods: Histological samples from 61 patients of invasive duct carcinoma (IDC) of no special type (NST), 12 cases of ductal carcinoma in situ (DCIS) and 14 control breast samples taken from fibrocystic change disease were retrospectively analyzed by computerized nuclear morphometry. All IDC patients underwent modified radical mastectomy without preoperative chemotherapy. The mean follow up was 28±19 months (range] -71). In each case, 25-50 nuclei were measured and the mean nuclear area (MNA), mean nuclear perimeter (MNP), mean maximum nuclear diameter (MMNO) and mean minimal nuclear diameter (Mmnd) were measured. The mean axis ratio (MAR), mean nuclear compactness (MNC), mean nuclear size (MNS) and mean shape factor (MSHF), were calculated mathematically. To measure the nuclear diameters, a new method was employed using the AutoCAD program. Morphometric parameters were compared with different clinico pathologic features, patient's survival and cell proliferative activity as determined by Ki-67 immunostaining which was evaluated quantitatively. Most of the morphometric parameters were significantly higher in DCIS and IDC groups than benign one. In IDC group morphometric features related to nuclear size (MNA, MNP, MMNO, Mmnd and MNS) were significantly correlated to most clinico pathologic features and cell proliferative activity assessed by Ki-67 immunostaining. However, the shape factor failed to achieve this correlation. The univariate analysis using Kaplan Meier curves indicated that short survival time was correlated with high nuclear morphometric values (MNA. MNP, MMND, Mmnd, MNS and MSHF). Moreover, the Spear man correlation analysis showed that Mmnd has the highest converse correlation with survival (r= -0.75, (ρ < 0.0001). In multivariate analysis

  16. Proliferative activity of elastin-like-peptides depends on charge and phase transition.

    Science.gov (United States)

    Yuan, Yuan; Koria, Piyush

    2016-03-01

    Elastin-like-peptides (ELPs) are stimulus-responsive protein-based polymers and are attractive biomaterials due to their biocompatibility and unique properties. This study shows that in addition to their physical properties, ELPs have biological activities that are conducive to tissue regeneration. Specifically, we found that ELPs induce fibroblast proliferation via cell surface heparan sulfate proteoglycans (HSPG). Furthermore, our data suggests that ELP based materials with differential proliferative potential can be designed by controlling the interaction of ELPs with HSPGs by incorporating either hydrophobic or positively charged residues within the ELP sequence. Fibroblast proliferation is important for granulation tissue formation which is important in chronic wounds as well as in healing of other tissues. The customizable biological activity of ELPs coupled with their unique physical properties will enable us to design novel, sustainable and cost effective therapies for different tissue regeneration applications. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 697-706, 2016. © 2015 Wiley Periodicals, Inc.

  17. Biocatalytically Oligomerized Epicatechin with Potent and Specific Anti-proliferative Activity for Human Breast Cancer Cells

    Directory of Open Access Journals (Sweden)

    Ramaswamy Nagarajan

    2008-11-01

    Full Text Available Catechins, naturally occurring flavonoids derived from wine and green tea, are known to exhibit multiple health benefits. Epigallocatechin gallate (EGCG is one of the most widely investigated catechins, but its efficacy in cancer therapy is still inconsistent and limited. The poor stability of EGCG has contributed to the disparity in the reported anti-cancer activity and other beneficial properties. Here we report an innovative enzymatic strategy for the oligomerization of catechins (specifically epicatechin that yields stable, water-soluble oligomerized epicatechins with enhanced and highly specific anti-proliferative activity for human breast cancer cells. This one-pot oxidative oligomerization is carried out in ambient conditions using Horseradish Peroxidase (HRP as a catalyst yielding water-soluble oligo(epicatechins. The oligomerized epicatechins obtained exhibit excellent growth inhibitory effects against human breast cancer cells with greater specificity towards growth-inhibiting cancer cells as opposed to normal cells, achieving a high therapeutic differential. Our studies indicate that water-soluble oligomeric epicatechins surpass EGCG in stability, selectivity and efficacy at lower doses.

  18. Extraction, purification and anti-proliferative activities of polysaccharides from Lentinus edodes.

    Science.gov (United States)

    Zhao, Yong-Ming; Wang, Jin; Wu, Zhi-Gang; Yang, Jian-Ming; Li, Wei; Shen, Li-Xia

    2016-12-01

    In this study, the enzyme-assisted extraction of polysaccharides from Lentinus edodes (LEPs) was optimized by response surface methodology, and a preliminary characterization of the extracted LEPs and their anti-proliferative activities were investigated. An orthogonal assay was constructed to determine the optimal amounts of cellulase, papain and pectinase, which were 15, 20 and 15g/kg, respectively. Then effects of extraction conditions were evaluated and optimized using a Box-Behnken design. The results showed that the highest polysaccharides yield of 15.65% was achieved with an extraction temperature of 54°C, pH 5.0, enzymatic treatment time of 93min and a liquid/material ratio of 29:1mL/g, which correlated well with the predicted yield of 15.58%. Subsequently, the crude LEPs were further purified by DEAE-cellulose and Sephadex-100 chromatography to obtain two fractions, which were designated as LEP-1 and LEP-2 and their monosaccharide compositions were characterized by GC. Fourier-transform infrared spectra demonstrated that LEP-1 and LEP-2 were distinct from each other regarding their chemical structures. In addition, the LEPs exhibited inhibition of cell proliferation on HCT-116 and HeLa cells in vitro. In summary, this study provides an efficient enzyme-assisted extraction for LEPs, which can be used as natural antitumor agents in the pharmaceutical and functional food industries. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. In vitro anti-proliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb

    Czech Academy of Sciences Publication Activity Database

    Landa, Přemysl; Skálová, L.; Boušová, I.; Kutil, Zsófia; Langhansová, Lenka; Lou, J.D.; Vaněk, Tomáš

    2014-01-01

    Roč. 27, č. 1 (2014), s. 103-106 ISSN 1011-601X R&D Projects: GA MŠk ME08070 Institutional support: RVO:61389030 Keywords : anti-proliferative activity * anti-inflammatory activity * breast cancer Subject RIV: EI - Biotechnology ; Bionics Impact factor: 0.682, year: 2014 http://www.pjps.pk/wp-content/uploads/pdfs/27/1/Paper-15.pdf

  20. THE BIOTIC FACTOR OF TREMATOD OPISTHORHIS FELINEUS INVASION INFLUENCE ON HOST IMMUNE STATUS AND SOMATIC CELLS PROLIFERATIVE ACTIVITY

    Directory of Open Access Journals (Sweden)

    A. G. Rybka

    2016-01-01

    Full Text Available The paper confirms long-time opisthorhis invasion role as a risk factor of host immune system reconstitution as well as an important factor in holangiocarcinomas development. It was shown that opisthorhosis invasion primal stage induce host immune system reconstitution. Host immune B-cells system is activated by metacercaria antigens, while the same antigens inhibits T-cells activity. Opisthorhis metabolites stimulate proliferative mithogen-induced T-cells acti vity. Chronic opisthorchis invasion leads to immune system disbalance. It means: decrease of specific and non-speci fic natural killers activity, number of high proliferative activity T-lymphocytes and the shift of regulatory T-cells subset to suppressors prevalence. At the same time specific as well as non-specific T-suppressors functional ability is very low. It was shown T-cells helper-amplifier activation. Despite of circulating B-cells decrease the antibody produced cells number is spleen increases significantly at the same time with circulating immune complexes accumulation. Even 3–6 month after dehelmintisation the immune system disbalance decreases but lefts. In addition, chronic opisthorhis invasion leads to the proliferative processes activation in ductal epithelium, liver, lymph nodes and in other organs which leads to cancer proliferation. According to the results obtained the opisthorhis infected patients needs to be immunocorrected before as well as after dehelmintisation for holangiocancerogenesis profylaxis.

  1. [Effect of low-intensity electromagnetic fields of industrial frequency on the ultrastructure and proliferative activity of rat's thymus cells].

    Science.gov (United States)

    Zhitkevich, T I; Bokut', T B; Netukova, N I

    2001-01-01

    Effects of two types of low-intensity electromagnetic fields (EMF) of industrial frequency (50 Hz) on the fine structure and proliferative activity of thymic cells in white rats were studied. It was found that a weak EMF with a prevailing electrical component (380-480 V/m, 120-140 nT1) did not affect the DNA synthesis intensity. An EMF with a stronger magnetic induction (10-15 V/m, 800-1500 nT1) diminished the glucose-6-phosphate dehydrogenase activity and proliferative processes in cultured stimulated lymphocytes. Electron microscopic investigation of the thymus after both types of exposure revealed an accumulation of lymphocytes with pyknotic nuclei and electron-dense cytoplasm, as well as hypoplasia of the vascular endothelium. At the same time, EMF with a prevailing magnetic component produced a more marked negative effect on the ultrastructure of thymic cells, which indicated a lowered secretory activity of epitheliocytes.

  2. Evaluation of cell proliferative activity after irradiation using immunohistochemical approach and flow cytometry

    Energy Technology Data Exchange (ETDEWEB)

    Tamada, Takashi (Okayama Univ. (Japan). School of Medicine)

    1992-06-01

    To evaluate a proliferative activity of post-irradiated malignant cells, we studied the kinetics of HeLa cells using immunohistochemical approach and flow cytometry. HeLa cells were stained with two proliferation-associated monoclonal antibodies, Ki-67 and anti-DNA polymerase {alpha} antibody. Nucleoli of non-irradiated cells were granularly stained with Ki-67. After irradiation, only the center of nuclei was diffusely stained with Ki-67. One hundred forty-four hours after low-dose irradiation, the staining patterns became the same as the control. On the other hand, after high-dose irradiation, the center of nuclei was weakly stained. DNA polymerase {alpha} was diffusely labelled with nuclei of the control. It was located around the border of nuclei of low-dose irradiated cells like a ring. But after high-dose irradiation, it was granularly distributed in the periphery of nuclei. FITC conjugated Ki-67/PI two parameter analysis was done by a single laser flow cytometer. Twenty-four hours after irradiation, DNA-histograms showed the accumulation to G{sub 2}/M phase and the increase of DNA content of G{sub 2}/M cells, as exposure dose was increased. Two parameter analysis showed the increase of FITC uptake of G{sub 2}/M phase as dose increased. These changes of flow cytometry were remarkably observed after 24 hours' incubation. It was shown that the difference of Ki-67 antigen and DNA polymerase {alpha} appearance depended on the irradiation dose. These findings suggest that immunohistochemical staining with Ki-67 or anti-DNA polymerase {alpha} antibody and flow cytometry using Ki-67 are available to evaluate cell damages after irradiation. (author).

  3. Azithromycin Synergistically Enhances Anti-Proliferative Activity of Vincristine in Cervical and Gastric Cancer Cells

    International Nuclear Information System (INIS)

    Zhou, Xuezhang; Zhang, Yuyan; Li, Yong; Hao, Xiujing; Liu, Xiaoming; Wang, Yujiong

    2012-01-01

    In this study, the anti-proliferative and anticancer activity of azithromycin (AZM) was examined. In the presence of AZM, cell growth was inhibited more effectively in Hela and SGC-7901 cancer cells, relative to transformed BHK-21 cells. The respective 50% inhibition of cell growth (IC 50 ) values for Hela, SGC-7901 and BHK-21 were 15.66, 26.05 and 91.00 µg/mL at 72 h post incubation, indicative of a selective cytotoxicity against cancer cells. Cell apoptosis analysis using Hoechst nuclear staining and annexin V-FITC binding assay further demonstrated that AZM was capable of inducing apoptosis in both cancer cells and transformed cells. The apoptosis induced by AZM was partly through a caspase-dependent mechanism with an up-regulation of apoptotic protein cleavage PARP and caspase-3 products, as well as a down-regulation of anti-apoptotic proteins, Mcl-1, bcl-2 and bcl-X1. More importantly, a combination of AZM and a low dose of the common anti-cancer chemotherapeutic agent vincristine (VCR), produced a selectively synergistic effect on apoptosis of Hela and SGC-7901 cells, but not BHK-21 cells. In the presence of 12.50 μg/mL of VCR, the respective IC 50 values of Hela, SGC-7901 and BHK-21 cells to AZM were reduced to 9.47 µg/mL, 8.43 µg/mL and 40.15 µg/mL at 72 h after the incubation, suggesting that the cytotoxicity of AZM had a selective anti-cancer effect on cancer over transformed cells in vitro. These results imply that AZM may be a potential anticancer agent for use in chemotherapy regimens, and it may minimize side effects via reduction of dosage and enhancing the effectiveness common chemotherapeutic drugs

  4. Structural and functional development of rat and mouse gastric mucous cells in relation to their proliferative activity

    International Nuclear Information System (INIS)

    Wattel, W.

    1978-01-01

    An investigation has been carried out to find a relation between the differentiation and the mitotic activity of gastric mucous cells of the rat and the mouse. It is shown that the bulk mucous production is carried out by the older, non-proliferative, surface mucous cells that line the foveolae and the gastric surface. One experiment describes the renewal of mouse gastric mucous cells following fast neutron irradiation. (C.F.)

  5. Phytochemical properties and anti-proliferative activity of Olea europaea L. leaf extracts against pancreatic cancer cells.

    Science.gov (United States)

    Goldsmith, Chloe D; Vuong, Quan V; Sadeqzadeh, Elham; Stathopoulos, Costas E; Roach, Paul D; Scarlett, Christopher J

    2015-07-17

    Olea europaea L. leaves are an agricultural waste product with a high concentration of phenolic compounds; especially oleuropein. Oleuropein has been shown to exhibit anti-proliferative activity against a number of cancer types. However, they have not been tested against pancreatic cancer, the fifth leading cause of cancer related death in Western countries. Therefore, water, 50% ethanol and 50% methanol extracts of Corregiola and Frantoio variety Olea europaea L. leaves were investigated for their total phenolic compounds, total flavonoids and oleuropein content, antioxidant capacity and anti-proliferative activity against MiaPaCa-2 pancreatic cancer cells. The extracts only had slight differences in their phytochemical properties, and at 100 and 200 μg/mL, all decreased the viability of the pancreatic cancer cells relative to controls. At 50 μg/mL, the water extract from the Corregiola leaves exhibited the highest anti-proliferative activity with the effect possibly due to early eluting HPLC peaks. For this reason, olive leaf extracts warrant further investigation into their potential anti-pancreatic cancer benefits.

  6. Literary, Memory, Reading and Teaching

    Directory of Open Access Journals (Sweden)

    Guaraciaba Micheletti

    2016-07-01

    Full Text Available The teaching of literature even when focused on reading is often overlooked in the face of other classroom needs. The teaching of reading, without well-defined object, is emphasized by performing as a concern of all areas and not only in mother-tongue classes. However, a closer look reveals that this is exactly the reading of literary texts that provides answers to questions from other spheres (LAJOLO, 1982; 1993; COSSON, 2006. In this article, taking as a basis, the intertextuality, one of the constituent elements of literary texts (MAINGUENEAU, 2004, we propose some reflections on the role of literary literacy by presenting suggestions for activities, based on the concept of teacher as mediator of the dialogues constituted in the literary text and other derivatives of these dialogues in the classroom.

  7. In vitro anti-proliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb.

    Science.gov (United States)

    Landa, Premysl; Skalova, Lenka; Bousova, Iva; Kutil, Zsofia; Langhansova, Lenka; Lou, Ji-Dong; Vanek, Tomas

    2014-01-01

    The aim of this study was to evaluate in vitro anti-proliferative (tested on MCF-7, MDA-MB-231, and MCF-10A cell lines) and anti-inflammatory (evaluated as inhibition of prostaglandin E2 synthesis catalyzed by cyclooxygenase-2) effect of various extracts from Vaccinium bracteatum leaves and fruits. The highest anti-proliferative effect possessed leaf dichloromethane extract with IC50 values ranging from 93 to 198 μg/mL. In the case of cyclooxygenase-2 inhibition, n-hexane, dichloromethane, and ethanol fruit extracts showed the best activity with IC50 values = 2.0, 5.4, and 12.7 μg/mL, respectively. These results indicate that V. bracteatum leaves and fruits could be useful source of anti-cancer and anti-inflammatory compounds.

  8. Anti-proliferative activity of the quassinoid NBT-272 in childhood medulloblastoma cells

    Directory of Open Access Journals (Sweden)

    Helson Lawrence

    2007-01-01

    Full Text Available Abstract Background With current treatment strategies, nearly half of all medulloblastoma (MB patients die from progressive tumors. Accordingly, the identification of novel therapeutic strategies remains a major goal. Deregulation of c-MYC is evident in numerous human cancers. In MB, over-expression of c-MYC has been shown to correlate with anaplasia and unfavorable prognosis. In neuroblastoma – an embryonal tumor with biological similarities to MB – the quassinoid NBT-272 has been demonstrated to inhibit cellular proliferation and to down-regulate c-MYC protein expression. Methods To study MB cell responses to NBT-272 and their dependence on the level of c-MYC expression, DAOY (wild-type, empty vector transfected or c-MYC transfected, D341 (c-MYC amplification and D425 (c-MYC amplification human MB cells were used. The cells were treated with different concentrations of NBT-272 and the impact on cell proliferation, apoptosis and c-MYC expression was analyzed. Results NBT-272 treatment resulted in a dose-dependent inhibition of cellular proliferation (IC50 in the range of 1.7 – 9.6 ng/ml and in a dose-dependent increase in apoptotic cell death in all human MB cell lines tested. Treatment with NBT-272 resulted in up to 90% down-regulation of c-MYC protein, as demonstrated by Western blot analysis, and in a significant inhibition of c-MYC binding activity. Anti-proliferative effects were slightly more prominent in D341 and D425 human MB cells with c-MYC amplification and slightly more pronounced in c-MYC over-expressing DAOY cells compared to DAOY wild-type cells. Moreover, treatment of synchronized cells by NBT-272 induced a marked cell arrest at the G1/S boundary. Conclusion In human MB cells, NBT-272 treatment inhibits cellular proliferation at nanomolar concentrations, blocks cell cycle progression, induces apoptosis, and down-regulates the expression of the oncogene c-MYC. Thus, NBT-272 may represent a novel drug candidate to inhibit

  9. Immunohistochemical Estimates of Angiogenesis, Proliferative Activity, p53 Expression, and Multiple Drug Resistance Have No Prognostic Impact in Osteosarcoma: A Comparative Clinicopathological Investigation

    DEFF Research Database (Denmark)

    Sørensen, Flemming Brandt; Jensen, Kenneth; Vaeth, Michael

    2008-01-01

    Purpose. To investigate angiogenesis, multiple drug resistance (MDR) and proliferative activity as prognostic variables in patients suffering from osteosarcoma. Methods. Histologic biopsies from 117 patients treated in the period from 1972 through 1999 were immunohistologically investigated...

  10. Proliferative activity of benign human prostate, prostatic adenocarcinoma and seminal vesicle evaluated by thymidine labeling

    International Nuclear Information System (INIS)

    Meyer, J.S.; Sufrin, G.; Martin, S.A.

    1982-01-01

    The thymidine labeling index (TLI) was measured in vitro in the epithelium and stroma of benign prostate glands and seminal vesicles and in the epithelium of prostatic adenocarcinomas. The mean epithelial TLI of normal peripheral (posterior) prostatic zone was 0.12 percent, and that of the normal central (deep) zone was 0.11 percent. Mean normal stromal TLI's were 0.08 percent and 0.06 percent, respectively. The mean TLI of epithelium in nodular hyperplasia was 0.31 percent, which differs significantly from normal epithelium (p less than 0.05), and the mean stromal TLI was also increased (0.16 percent, p less than 0.1). The mean TLI of prostatic adenocarcinomas was 0.90 percent (range 0.14 to 3.90 percent) which was significantly higher than for either normal epithelium (p less than 0.001) or epithelium of nodular hyperplasia (p less than 0.05). Trends of increasing TLI with increasing histologic grades and increasing nuclear size and numbers of nucleoli were not significant. The data support participation of both epithelial and stromal proliferation in nodular hyperplasia, and indicate a low basal proliferative rate in normal prostatic glands. The low TLI's of prostatic adenocarcinomas relative to other malignancies are consistent with their frequently slowly progressive course. The very low proliferative rate of seminal vesicular epithelium (mean TLI 0.02 percent) may account for the rarity of seminal vesicular carcinomas

  11. Proliferative activity of benign human prostate, prostatic adenocarcinoma and seminal vesicle evaluated by thymidine labeling

    International Nuclear Information System (INIS)

    Meyer, J.S.; Sufrin, G.; Martin, S.A.

    1982-01-01

    The thymidine labeling index (TLI) was measured in vitro in the epithelium and stroma of benign prostate glands and seminal vesicles and in the epithelium of prostatic adenocarcinomas. The mean epithelial TLI of normal peripheral (posterior) prostatic zone was 0.12 per cent, and that of the normal central (deep) zone was 0.11 per cent. Mean normal stromal TLI's were 0.08 per cent and 0.06 per cent, respectively. The mean TLI of epithelium in nodular hyperplasia was 0.31 per cent, which differs significantly from normal epithelium, and the mean stromal TLI was also increased. The mean TLI of prostatic adenocarcinomas was 0.90 per cent (range 0.14 to 3.90 per cent) which was significantly higher than for either normal epithelium or epithelium of nodular hyperplasia. Trends of increasing TLI with increasing histologic grades and increasing nuclear size and numbers of nucleoli were not significant. The data support participation of both epithelial and stromal proliferation in nodular hyperplasia, and indicate a low basal proliferative rate in normal prostatic glands. The low TLI's of prostatic adenocarcinomas relative to other malignancies are consistent with their frequently slowly progressive course. The very low proliferative rate of seminal vesicular epithelium may account for the rarity of seminal vesicular carcinomas

  12. F-18-FDG positron emission tomography findings correlate pathological proliferative activity of oral squamous cell carcinoma

    International Nuclear Information System (INIS)

    Toyoizumi, Osamu; Oriuchi, Noboru; Miyakubo, Mitsuyuki

    2010-01-01

    It is still controversial whether fluorodeoxyglucose (FDG) uptake is correlated with cellular proliferation and prognosis of oral squamous cell carcinoma (OSC). In this study, we performed positron emission tomography (PET) study and immunohistochemical analysis to elucidate the relationship between FDG uptake and expression of cellular proliferative markers and pathological prognostic markers in patients with OSC. FDG PET and immunohistochemical staining have been carried out in sixteen patients with OSC. Tumor uptake of FDG was expressed with standardized uptake value (SUV). The expression of Ki-67, Topoisomerase IIα (Topo IIα), p53, and p63 in cancer cells was quantitatively assessed with positivity of the immunohistochemical staining. SUV was compared with the results of immunohistochemical analysis. FDG PET study revealed that SUV ranged from 3.6 to 22.1 with average of 10.4. Average positive rate of Ki-67, Topo IIα, p53, and p63 was 68.9%, 58.9%, 72.0%, and 65.2%, respectively. Pearson product-moment correlation coefficient analysis revealed that SUV was significantly correlated with Ki-67 (r=0.616, p=0.01), Topo IIα (r=0.677, p=0.004), p53 (r=0.613, p=0.01), and p63 (r=0.710, p=0.002), respectively. The present preliminary study indicated that FDG uptake was closely correlated with pathological cellular proliferative and prognostic markers in patients with OSC. (author)

  13. Daphne striata Tratt. and D. mezereum L.: a study of anti-proliferative activity towards human cancer cells and antioxidant properties.

    Science.gov (United States)

    Tundis, Rosa; Loizzo, Monica R; Bonesi, Marco; Peruzzi, Lorenzo; Efferth, Thomas

    2018-02-12

    In this study, we investigated for the first time the anti-proliferative and antioxidant properties of D. mezereum and D. striata. The aerial parts were extracted by maceration with n-hexane, dichloromethane, and methanol. MPLC, GC, and GC-MS were used for the phytochemical study. The anti-proliferative activity was tested against MCF-7, A549, LNCaP, ACHN, and C32 cancer human cells. The antioxidant activity was measured by employing β-carotene bleaching, ABTS, DPPH, and FRAP tests. The Relative Antioxidant Capacity Index (RACI) was applied from the perspective of statistics. D. mezereum dichloromethane extract showed a remarkable anti-proliferative with an IC 50 of 6.08 μg/mL against LNCaP cells. Experimental data indicate that Daphne species have interesting anti-proliferative and antioxidant properties that deserve more investigations to develop novel antineoplastic drugs.

  14. Curcumin Conjugated with PLGA Potentiates Sustainability, Anti-Proliferative Activity and Apoptosis in Human Colon Carcinoma Cells

    Science.gov (United States)

    Waghela, Bhargav N.; Sharma, Anupama; Dhumale, Suhashini; Pandey, Shashibahl M.; Pathak, Chandramani

    2015-01-01

    Curcumin, an ingredient of turmeric, exhibits a variety of biological activities such as anti-inflammatory, anti-atherosclerotic, anti-proliferative, anti-oxidant, anti-cancer and anti-metastatic. It is a highly pleiotropic molecule that inhibits cell proliferation and induces apoptosis in cancer cells. Despite its imperative biological activities, chemical instability, photo-instability and poor bioavailability limits its utilization as an effective therapeutic agent. Therefore, enhancing the bioavailability of curcumin may improve its therapeutic index for clinical setting. In the present study, we have conjugated curcumin with a biodegradable polymer Poly (D, L-lactic-co-glycolic acid) and evaluated its apoptotic potential in human colon carcinoma cells (HCT 116). The results show that curcumin-PLGA conjugate efficiently inhibits cell proliferation and cell survival in human colon carcinoma cells as compared to native curcumin. Additionally, curcumin conjugated with PLGA shows improved cellular uptake and exhibits controlled release at physiological pH as compared to native curcumin. The curcumin-PLGA conjugate efficiently activates the cascade of caspases and promotes intrinsic apoptotic signaling. Thus, the results suggest that conjugation potentiates the sustainability, anti-proliferative and apoptotic activity of curcumin. This approach could be a promising strategy to improve the therapeutic index of cancer therapy. PMID:25692854

  15. GTP depletion synergizes the anti-proliferative activity of chemotherapeutic agents in a cell type-dependent manner

    International Nuclear Information System (INIS)

    Lin, Tao; Meng, Lingjun; Tsai, Robert Y.L.

    2011-01-01

    Highlights: → Strong synergy between mycophenolic acid (MPA) and 5-FU in MDA-MB-231 cells. → Cell type-dependent synergy between MPA and anti-proliferative agents. → The synergy of MPA on 5-FU is recapitulated by RNA polymerase-I inhibition. → The synergy of MPA on 5-FU requires the expression of nucleostemin. -- Abstract: Mycophenolic acid (MPA) depletes intracellular GTP by blocking de novo guanine nucleotide synthesis. GTP is used ubiquitously for DNA/RNA synthesis and as a signaling molecule. Here, we made a surprising discovery that the anti-proliferative activity of MPA acts synergistically with specific chemotherapeutic agents in a cell type-dependent manner. In MDA-MB-231 cells, MPA shows an extremely potent synergy with 5-FU but not with doxorubicin or etoposide. The synergy between 5-FU and MPA works most effectively against the highly tumorigenic mammary tumor cells compared to the less tumorigenic ones, and does not work in the non-breast cancer cell types that we tested, with the exception of PC3 cells. On the contrary, MPA shows the highest synergy with paclitaxel but not with 5-FU in SCC-25 cells, derived from oral squamous cell carcinomas. Mechanistically, the synergistic effect of MPA on 5-FU in MDA-MB-231 cells can be recapitulated by inhibiting the RNA polymerase-I activity and requires the expression of nucleostemin. This work reveals that the synergy between MPA and anti-proliferative agents is determined by cell type-dependent factors.

  16. Chemical composition, antioxidant, anti-inflammatory and anti-proliferative activities of essential oils of plants from Burkina Faso.

    Directory of Open Access Journals (Sweden)

    Bagora Bayala

    Full Text Available This research highlights the chemical composition, antioxidant, anti-inflammatory and anti-proliferative activities of essential oils from leaves of Ocimum basilicum, Ocimum americanum, Hyptis spicigera, Lippia multiflora, Ageratum conyzoides, Eucalyptus camaldulensis and Zingiber officinale. Essential oils were analyzed by gas chromatography-mass spectrometry and gas chromatography-flame ionization detector. Major constituents were α-terpineol (59.78% and β-caryophyllene (10.54% for Ocimum basilicum; 1, 8-cineol (31.22%, camphor (12.730%, α-pinene (6.87% and trans α-bergamotene (5.32% for Ocimum americanum; β-caryophyllene (21%, α-pinene (20.11%, sabinene (10.26%, β-pinene (9.22% and α-phellandrene (7.03% for Hyptis spicigera; p-cymene (25.27%, β-caryophyllene (12.70%, thymol (11.88, γ-terpinene (9.17% and thymyle acetate (7.64% for Lippia multiflora; precocene (82.10%for Ageratum conyzoides; eucalyptol (59.55%, α-pinene (9.17% and limonene (8.76% for Eucalyptus camaldulensis; arcurcumene (16.67%, camphene (12.70%, zingiberene (8.40%, β-bisabolene (7.83% and β-sesquiphellandrène (5.34% for Zingiber officinale. Antioxidant activities were examined using 1,1-diphenyl-2-picryl-hydrazyl (DPPH and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS methods. O. basilicum and L. multiflora exhibited the highest antioxidant activity in DPPH and ABTS tests, respectively. Anti-inflammatory properties were evaluated by measuring the inhibition of lipoxygenase activity and essential oil of Z. officinale was the most active. Anti-proliferative effect was assayed by the measurement of MTT on LNCaP and PC-3 prostate cancer cell lines, and SF-763 and SF-767 glioblastoma cell lines. Essential oils from A. conyzoides and L. multiflora were the most active on LNCaP and PC-3 cell lines, respectively. The SF-767 glioblastoma cell line was the most sensitive to O. basilicum and L. multiflora EOs while essential oil of A. conyzoides showed the

  17. Two novel prenylated kaempferol derivatives from fresh bud's fur of Platanus acerifolia and their anti-proliferative activities.

    Science.gov (United States)

    Zuo, Bo; Liao, Zhi-Xin; Xu, Chen; Liu, Chao

    2016-01-06

    Two novel prenylated kaempferol derivatives (1, 2), together with seven known metabolites were isolated from ethanol extract of fresh Platanus acerifolia bud's fur by multistep chromatographic processing. Structure of compounds 1 and 2 was confirmed by 1D, 2D NMR spectra and HR-ESI-MS. In addition, compound 1 was further analysed by X-ray crystallography. Anti-proliferative activities in vitro against human breast carcinoma (MCF-7) and human hepatocellular carcinoma (Hep-G2) cell lines for compound 1, 2 and 8 were evaluated. Compound 1 exhibited cytotoxic activity towards MCF-7 and Hep-G2 cell lines with the IC 50 values 38.2 and 39.5 μM, respectively. Moreover, compound 2 showed weak cytotoxic activities against the two cell lines.

  18. Are Literary Translators (still) Lone Wolves?

    DEFF Research Database (Denmark)

    Jansen, Hanne

    2017-01-01

    of a questionnaire on collaboration within literary translation in Scandinavia. Concepts from Community Studies, such as generalized reciprocity, interpersonal trust and active participation, are employed to discuss whether literary translators feel like members of a community, lone wolves, or simply lonely....

  19. A Literary Review and a Plan for Principals: Extracurricular Activities, Academic Achievement, and Secondary Students' Success.

    Science.gov (United States)

    Reynolds, Richard Kent; Karr-Kidwell, PJ

    Extracurricular activities have enhanced the lives of students through the years and continue to provide students with additional skills they need to succeed in school and life. This paper offers an extensive literature review of the effect of extracurricular activities on student development and offers a plan for extending successful…

  20. Proliferative activity of vervet monkey bone marrow-derived adherent cells

    International Nuclear Information System (INIS)

    Kramvis, A.; Garnett, H.M.

    1987-01-01

    Vervet monkey bone marrow-derived adherent cell population cultured in Fischer's medium supplemented with 12.5% fetal calf serum and 12.5% horse serum consists of two cell shapes: fusiform (type I) and polygonal (type II). Limiting-dilution cloning of the cells suggested that the two morphologically distinct cell types belong to the same cellular system even though they differ in their proliferative capabilities. The labeling index of type II cells, as measured by autoradiography, was found to be consistently lower than that of type I cells. It is probable that these two phenotypes represent different stages of differentiation, where progenitor type I gives rise to type II cells. The bone marrow-derived adherent cells were found to be cytokinetically at rest in vivo, using the thymidine suicide test, and relatively radioresistant with a D0 = 2.1 Gy and n = 2.36 at the time of explantation from the bone. Furthermore, in culture these cells are characterized by a relatively long cell cycle of 60 h, where the length of the S phase is 30 h, G2 is 12 h, M is 6 h, and G1 is 12 h. Thus, the vervet monkey bone marrow-derived adherent cells represent a cell population with a low turnover rate both in vivo and in vitro

  1. Steroid hormones as regulators of the proliferative activity of normal and neoplastic intestinal epithelial cells (review).

    Science.gov (United States)

    Tutton, P J; Barkla, D H

    1988-01-01

    Glucocorticoid and mineralocorticoid receptors are present in normal epithelial cells of both the small and large intestine and there have also been contentious reports of androgen, oestrogen and progesterone receptors in the epithelium of the normal large intestine. The majority of reports suggest that stimulation of the intestinal glucocorticoid receptors results in increased proliferation of epithelial cells in the small bowel, as does stimulation of androgen receptors and possibly mineralocorticoid receptors. The proliferative response of the normal intestine to oestrogens is difficult to evaluate and that to progestigens appears not to have been reported. Epidemiological studies reveal a higher incidence of bowel cancer in premenopausal women than in men of the same age and yet there is a lower incidence of these tumors in women of higher parity. These findings have been atributted to a variety of non-epithelial gender characteristic such as differences in bile metabolism, colonic bacterial and fecal transit times. In experimental animals, androgens have also been shown to influence carcinogenesis and this could well be attributed to changes in food intake etc. However, many studies have now revealed steroid hormone receptors on colorectal tumor cells and thus a direct effect of the steroid hormones on the epithelium during and after malignant transformation must now be considered.

  2. Inhibition of proliferative activity in tissue culture in vivo of esophagus and stomach tumour cells under preoperative irradiation

    International Nuclear Information System (INIS)

    Zinchenko, V.A.; Okulov, L.V.; Gol'dshmid, B.Ya.

    1988-01-01

    Inhibition of proliferative activity of tumor cells as a result of radiation effect. Tumor tissue taken from patiets with preoperative tumor irradiation by 30 Gy cumulative dose (5 Gy per a session) and from patients whose tumors were not subjected to irradiation (control) was used. The tumor tissue was cultivated in the diffusion chamber and then implanted to the abdominal cavity of the non-inbred male rats. On preparations in the growth area pathomorphological changes were evaluated, the share of mitotically dividing and DNA-synthesizing cells was determined. The absence of growth area around the explant, obvious reduction of mitotic activity and DNA-synthesizing function of cells in preparations of irradiated tumors in 88 % of cases testify to the inhibition of the stomach cardial section and esophagus tumor tissue repopulation after radiation effect. The investigation results confirm the advisability of preoperative irradiation of patients with tumors of the given localization

  3. Downregulation of TXNIP leads to high proliferative activity and estrogen-dependent cell growth in breast cancer.

    Science.gov (United States)

    Park, Jun Won; Lee, Su Hyung; Woo, Gye-Hyung; Kwon, Hyo-Jung; Kim, Dae-Yong

    2018-04-06

    TXNIP is a potent tumor suppressor with reduced expression in various types of human cancer. The prognostic and predictive power of TXNIP has been recognized in human breast cancer. The aim of this study is to investigate the clinical relevance and functional roles of TXNIP downregulation in breast cancer. We examined TXNIP expression at the protein level in tissue microarray (TMA)-based human breast cancers and its correlation with clinical parameters and molecular markers on immunohistochemistry (IHC). Compared with normal tissues, TXNIP expression was significantly decreased in human breast cancer tissues and animal mammary tumors, along with tumor progression. TXNIP was restored immediately after histone deacetylase inhibitor treatment in breast cancer cells, implying transcriptional regulation of TXNIP by histone modification. Decreased TXNIP protein levels were more common in tumors showing high proliferative activity, such as high Ki-67 labeling indexes and low p27 expression. TXNIP knockdown led to increased in vitro and in vivo breast cancer cell growth accompanied by p27 reduction and GLUT1 induction. Interestingly, estrogen receptor (ER)-positive breast cancer samples showed higher TXNIP expression compared to ER-negative samples. TXNIP expression decreased when ER signaling was activated by estradiol, while its expression increased under ER blockage by anti-estrogen fulvestrant. In addition, TXNIP knockdown in breast cancer cells caused significant reduction in the cell-growth inhibitory effect of anti-estrogen fulvestrant. In conclusion, our data demonstrated that TXNIP functions to suppress high proliferative activity and estrogen-dependent cell growth in breast cancer. Copyright © 2018 Elsevier Inc. All rights reserved.

  4. Increased Stiffness in Aged Skeletal Muscle Impairs Muscle Progenitor Cell Proliferative Activity.

    Directory of Open Access Journals (Sweden)

    Grégory Lacraz

    Full Text Available Skeletal muscle aging is associated with a decreased regenerative potential due to the loss of function of endogenous stem cells or myogenic progenitor cells (MPCs. Aged skeletal muscle is characterized by the deposition of extracellular matrix (ECM, which in turn influences the biomechanical properties of myofibers by increasing their stiffness. Since the stiffness of the MPC microenvironment directly impacts MPC function, we hypothesized that the increase in muscle stiffness that occurs with aging impairs the behavior of MPCs, ultimately leading to a decrease in regenerative potential.We showed that freshly isolated individual myofibers from aged mouse muscles contain fewer MPCs overall than myofibers from adult muscles, with fewer quiescent MPCs and more proliferative and differentiating MPCs. We observed alterations in cultured MPC behavior in aged animals, where the proliferation and differentiation of MPCs were lower and higher, respectively. These alterations were not linked to the intrinsic properties of aged myofibers, as shown by the similar values for the cumulative population-doubling values and fusion indexes. However, atomic force microscopy (AFM indentation experiments revealed a nearly 4-fold increase in the stiffness of the MPC microenvironment. We further showed that the increase in stiffness is associated with alterations to muscle ECM, including the accumulation of collagen, which was correlated with higher hydroxyproline and advanced glycation end-product content. Lastly, we recapitulated the impaired MPC behavior observed in aging using a hydrogel substrate that mimics the stiffness of myofibers.These findings provide novel evidence that the low regenerative potential of aged skeletal muscle is independent of intrinsic MPC properties but is related to the increase in the stiffness of the MPC microenvironment.

  5. In vitro anti-proliferative activity on colon cancer cell line (HT-29) of Thai medicinal plants selected from Thai/Lanna medicinal plant recipe database "MANOSROI III".

    Science.gov (United States)

    Manosroi, Aranya; Akazawa, Hiroyuki; Akihisa, Toshihiro; Jantrawut, Pensak; Kitdamrongtham, Worapong; Manosroi, Worapaka; Manosroi, Jiradej

    2015-02-23

    Thai/Lanna region has its own folklore wisdoms including the traditional medicinal plant recipes. Thai/Lanna medicinal plant recipe database "MANOSROI III" has been developed by Prof. Dr. Jiradej Manosroi. It consists of over 200,000 recipes for all diseases including cancer. To investigate the anti-proliferative and apoptotic activities on human colon cancer cell line (HT-29) as well as the cancer cell selectivity of the methanolic extracts (MEs) and fractions of the 23 selected plants from the "MANOSROI III" database. The 23 selected plants were extracted with methanol under reflux and evaluated for their anti-proliferative activity by sulforhodamine B assay. The 5 plants (Gloriosa superba, Caesalpinia sappan, Fibraurea tinctoria, Ventilago denticulata and Psophocarpus tetragonolobus) with potent anti-proliferative activity were fractionated by liquid-liquid partition to give 4 fractions including each hexane (HF), methanol-water (MF), n-butanol (BF) and water (WF) fractions. They were tested for anti-proliferative activity and cancer cell selectivity. The ME and fractions of G. superba which showed potent anti-proliferative activity were further examined for morphological changes and apoptotic activities by acridine orange (AO)/ethidium bromide (EB) staining. The ME of G. superba root showed active with the highest anti-proliferative activity at 9.17 and 1.58 folds of cisplatin and doxorubicin, respectively. After liquid-liquid partition, HF of V. denticulata, MFs of F. tinctoria, V. denticulata and BF of P. tetragonolobus showed higher anti-proliferative activities than their MEs. The MF of G. superba indicated the highest anti-proliferative activity at 7.73 and 1.34 folds of cisplatin and doxorubicin, respectively, but only 0.86 fold of its ME. The ME and HF, MF and BF of G. superba and MF of F. tinctoria demonstrated high cancer cell selectivity. At 50 µg/ml, ME, HF, MF and BF of G. superba demonstrated higher apoptotic activities than the two standard drugs

  6. Proliferative and anti-proliferative effects of dietary levels of phytoestrogens in rat pituitary GH3/B6/F10 cells - the involvement of rapidly activated kinases and caspases

    International Nuclear Information System (INIS)

    Jeng, Yow-Jiun; Watson, Cheryl S

    2009-01-01

    Phytoestogens are a group of lipophillic plant compounds that can have estrogenic effects in animals; both tumorigenic and anti-tumorigenic effects have been reported. Prolactin-secreting adenomas are the most prevalent form of pituitary tumors in humans and have been linked to estrogen exposures. We examined the proliferative effects of phytoestrogens on a rat pituitary tumor cell line, GH 3 /B 6 /F 10 , originally subcloned from GH 3 cells based on its ability to express high levels of the membrane estrogen receptor-α. We measured the proliferative effects of these phytoestrogens using crystal violet staining, the activation of several mitogen-activated protein kinases (MAPKs) and their downstream targets via a quantitative plate immunoassay, and caspase enzymatic activities. Four phytoestrogens (coumestrol, daidzein, genistein, and trans-resveratrol) were studied over wide concentration ranges. Except trans-resveratrol, all phytoestrogens increased GH 3 /B 6 /F 10 cell proliferation at some concentration relevant to dietary levels. All four phytoestrogens attenuated the proliferative effects of estradiol when administered simultaneously. All phytoestrogens elicited MAPK and downstream target activations, but with time course patterns that often differed from that of estradiol and each other. Using selective antagonists, we determined that MAPKs play a role in the ability of these phytoestrogens to elicit these responses. In addition, except for trans-resveratrol, a serum removal-induced extrinsic apoptotic pathway was blocked by these phytoestrogens. Phytoestrogens can block physiological estrogen-induced tumor cell growth in vitro and can also stimulate growth at high dietary concentrations in the absence of endogenous estrogens; these actions are correlated with slightly different signaling response patterns. Consumption of these compounds should be considered in strategies to control endocrine tumor cell growth, such as in the pituitary

  7. Triterpenoid Saponins from Anemone rivularis var. Flore-Minore and Their Anti-Proliferative Activity on HSC-T6 Cells.

    Science.gov (United States)

    Wang, Xiao-Yang; Gao, Hui; Xie, Xiao-Jie; Jurhiin, Jirimubatu; Zhang, Mu-Zi-He; Zhou, Yan-Ping; Liu, Rui; Ning, Meng; Han, Jin; Tang, Hai-Feng

    2018-02-23

    Five previously undescribed triterpenoid saponins ( 1 - 5 ), along with eight known ones ( 6 - 13 ), were isolated from the whole plants of Anemone rivularis var. flore-minore . Their structures were clarified by extensive spectroscopic data and chemical evidence. For the first time, the lupane-type saponins ( 3 and 12 ) were reported from the Anemone genus. The anti-proliferative activity of all isolated saponins was evaluated on hepatic stellate cells (HSC-T6). Saponins 12 and 13 , which possess more monosaccharides than the others, displayed potent anti-proliferative activity, with IC 50 values of 18.21 and 15.56 μM, respectively.

  8. Biogenic amines as regulators of the proliferative activity of normal and neoplastic intestinal epithelial cells (review).

    Science.gov (United States)

    Tutton, P J; Barkla, D H

    1987-01-01

    embryonic origin and that cells exhibiting an admixture of endocrine and proliferative properties exist in colonic tumours, but not in the normal intestinal epithelium. Thus, it appears that in the normal intestine a clear structural and functional distinction exists between the regulating cells (i.e. the sympathetic neurones and enteroendocrine cells) and the regulated cells (i.e. the undifferentiated crypt cells): cells that have acquired a regulating role are no longer able to divide and cells which are able to divide do not take up or store amines.(ABSTRACT TRUNCATED AT 400 WORDS)

  9. Anti-proliferative and apoptosis-inducing activity of lycopene against three subtypes of human breast cancer cell lines

    Science.gov (United States)

    Takeshima, Mikako; Ono, Misaki; Higuchi, Takako; Chen, Chen; Hara, Takayuki; Nakano, Shuji

    2014-01-01

    Although lycopene, a major carotenoid component of tomatoes, has been suggested to attenuate the risk of breast cancer, the underlying preventive mechanism remains to be determined. Moreover, it is not known whether there are any differences in lycopene activity among different subtypes of human breast cancer cells. Using ER/PR positive MCF-7, HER2-positive SK-BR-3 and triple-negative MDA-MB-468 cell lines, we investigated the cellular and molecular mechanism of the anticancer activity of lycopene. Lycopene treatment for 168 consecutive hours exhibited a time-dependent and dose-dependent anti-proliferative activity against these cell lines by arresting the cell cycle at the G0/G1 phase at physiologically achievable concentrations found in human plasma. The greatest growth inhibition was observed in MDA-MB-468 where the sub-G0/G1 apoptotic population was significantly increased, with demonstrable cleavage of PARP. Lycopene induced strong and sustained activation of the ERK1/2, with concomitant cyclin D1 suppression and p21 upregulation in these three cell lines. In triple negative cells, lycopene inhibited the phosphorylation of Akt and its downstream molecule mTOR, followed by subsequent upregulation of proapoptotic Bax without affecting anti-apoptotic Bcl-xL. Taken together, these data indicate that the predominant anticancer activity of lycopene in MDA-MB-468 cells suggests a potential role of lycopene for the prevention of triple negative breast cancer. PMID:24397737

  10. TU-F-12A-02: Quantitative Characterization of Normal Bone Marrow Proliferative Activity with FLT PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Weisse, N; Jeraj, R [Department of Medical Physics, University of Wisconsin, Madison, WI (United States)

    2014-06-15

    Purpose: [F-18]FLT PET is a tool for assessing health of bone marrow by evaluating its proliferative activity. This study establishes a baseline quantitative characterization of healthy marrow proliferation to aid in diagnosis of hematological disease. Methods: 31 patients (20 male, 11 female, 41–76 years) being treated for solid cancers with no history of hematological disease, osseous metastatic disease, or radiation therapy received pre-treatment FLT PET/CT scans. Total bone marrow was isolated from whole body FLT PET images by manually removing organs and applying a standardize uptake value (SUV) threshold of 1.0. Because adult marrow is concentrated in the axial skeleton, quantitative total bone marrow analysis (QTBMA) was used to isolate marrow in the lumbar spine, thoracic spine, sacrum, and pelvis for analysis. SUVmean, SUVmax, and SUVCV were used to quantify bone marrow proliferation. Correlations were explored between SUV and patient characteristics including age, weight, height, and BMI using the Spearman coefficient (ρ). Results: The population-averaged whole-skeleton SUVmean, SUVmax, and SUVCV were 3.0±0.6, 18.4±5.7, and 0.6±0.1, respectively. Uptake values in the axial skeleton were similar to the whole-skeleton demonstrated by SUVmean in the thoracic spine (3.6±0.6), lumbar spine (3.3±0.5), sacrum (3.0±0.6), and pelvis regions (2.8±0.5). Whole-skeleton SUVmax correlated with patient weight (ρ=0.47, p<0.01) and BMI (ρ=0.60, p<0.01), suggesting marrow activity is related to the body's burden. SUV measures in the thoracic spine, lumbar spine, sacrum, and pelvis were negatively correlated with age (ρ:−0.41 to −0.46, p≤0.02). These negative correlations reflect the fact that active marrow in the adult skeleton is localized in the axial skeleton and decreases with age. Conclusions: Normal bone marrow characterizations were determined using FLT

  11. ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect

    OpenAIRE

    Zinecker, Heidi; Ouaret, Djamila; Ebner, Daniel; Gaidt, Moritz M.; Taylor, Steve; Aulicino, Anna; Jagielowicz, Marta; Hornung, Veit; Simmons, Alison

    2017-01-01

    Mitochondria form a highly dynamic network driven by opposing scission and fusion events. DRP1 is an essential modulator of mitochondrial fission and dynamics within mammalian cells. Its fission activity is regulated by posttranslational modifications such as activating phosphorylation at serine 616. DRP1 activity has recently been implicated as being dysregulated in numerous human disorders such as cancer and neurodegenerative diseases. Here we describe the development of a cell-based screen...

  12. Anti-proliferative action of vitamin D in MCF7 is still active after siRNA-VDR knock-down

    NARCIS (Netherlands)

    J.L. Costa (José); P.P. Eijk (Paul); M.A. van de Wiel (Mark); D. ten Berge (Derk); F. Schmitt (Fernando); C.J. Narvaez (Carmen); J. Welsh; B. Ylstra (Bauke)

    2009-01-01

    textabstractBackground: The active form of Vitamin D, 1,25-dihydroxyvitamin D3(1,25D), has strong anti-proliferative effects, yet the molecular mechanisms underneath this effect remain unclear. In contrast, the molecular mechanism of 1,25D for the regulation of calcium homeostasis has principally

  13. The prognostic value of oncogenic antigen 519 (OA-519) expression and proliferative activity detected by antibody MIB-1 in node-negative breast cancer

    DEFF Research Database (Denmark)

    Jensen, V; Ladekarl, M; Holm-Nielsen, P

    1995-01-01

    of invasion of skin or deep fascia (= T1N0M0 and T2N0M0). The median follow-up time was 104 months (range 5-143 months). Immunohistochemical analysis of OA-519 expression was performed on formalin-fixed, paraffin-embedded tissue. The proliferative activity was estimated using a Ki-67 equivalent monoclonal...

  14. Prolonged effect of fluid flow stress on the proliferative activity of mesothelial cells after abrupt discontinuation of fluid streaming

    International Nuclear Information System (INIS)

    Aoki, Shigehisa; Ikeda, Satoshi; Takezawa, Toshiaki; Kishi, Tomoya; Makino, Junichi; Uchihashi, Kazuyoshi; Matsunobu, Aki; Noguchi, Mitsuru; Sugihara, Hajime; Toda, Shuji

    2011-01-01

    Highlights: ► Late-onset peritoneal fibrosis leading to EPS remains to be elucidated. ► Fluid streaming is a potent factor for peritoneal fibrosis in PD. ► We focused on the prolonged effect of fluid streaming on mesothelial cell kinetics. ► A history of fluid streaming exposure promoted mesothelial proliferative activity. ► We have thus identified a potent new factor for late-onset peritoneal fibrosis. -- Abstract: Encapsulating peritoneal sclerosis (EPS) often develops after transfer to hemodialysis and transplantation. Both termination of peritoneal dialysis (PD) and transplantation-related factors are risks implicated in post-PD development of EPS, but the precise mechanism of this late-onset peritoneal fibrosis remains to be elucidated. We previously demonstrated that fluid flow stress induced mesothelial proliferation and epithelial–mesenchymal transition via mitogen-activated protein kinase (MAPK) signaling. Therefore, we speculated that the prolonged bioactive effect of fluid flow stress may affect mesothelial cell kinetics after cessation of fluid streaming. To investigate how long mesothelial cells stay under the bioactive effect brought on by fluid flow stress after removal of the stress, we initially cultured mesothelial cells under fluid flow stress and then cultured the cells under static conditions. Mesothelial cells exposed to fluid flow stress for a certain time showed significantly high proliferative activity compared with static conditions after stoppage of fluid streaming. The expression levels of protein phosphatase 2A, which dephosphorylates MAPK, in mesothelial cells changed with time and showed a biphasic pattern that was dependent on the duration of exposure to fluid flow stress. There were no differences in the fluid flow stress-related bioactive effects on mesothelial cells once a certain time had passed. The present findings show that fluid flow stress exerts a prolonged bioactive effect on mesothelial cells after termination

  15. Personal literary interpretation

    Directory of Open Access Journals (Sweden)

    Michał Januszkiewicz

    2015-11-01

    Full Text Available The article titled “Personal literary interpretation” deals with problems which have usually been marginalized in literary studies, but which seem to be very important in the context of the humanities, as broadly defined. The author of this article intends to rethink the problem of literary studies not in objective, but in personal terms. This is why the author wants to talk about what he calls personal literary interpretation, which has nothing to do with subjective or irrational thinking, but which is rather grounded in the hermeneutical rule that says that one must believe in order tounderstand a text or the other (where ‘believe’ also means: ‘to love’, ‘engage’, and ‘be open’. The article presents different determinants of this attitude, ranging from Dilthey to Heidegger and Gadamer. Finally, the author subscribes to the theory of personal interpretation, which is always dialogical.

  16. Prolifération filamenteuse en boues activées

    OpenAIRE

    Juzan, L.; Vedrenne, J.

    2010-01-01

    / Le développement excessif de bactéries filamenteuses en boues activées peut entrainer des dysfonctionnements biologiques tels qu'un foisonnement et/ou un moussage stable. Quels sont les moyens de prévention, de diagnostic et de traitement actuellement disponibles ?

  17. Preliminary in vitro evaluation of the anti-proliferative activity of guanylhydrazone derivatives.

    Science.gov (United States)

    França, Paulo H B; Da Silva-Júnior, Edeildo F; Aquino, Pedro G V; Santana, Antônio E G; Ferro, Jamylle N S; De Oliveira Barreto, Emiliano; Do Ó Pessoa, Cláudia; Meira, Assuero Silva; De Aquino, Thiago M; Alexandre-Moreira, Magna S; Schmitt, Martine; De Araújo-Júnior, João X

    2016-03-01

    Guanylhydrazones have shown promising antitumor activity in preclinical tumor models in several studies. In this study, we aimed at evaluating the cytotoxic effect of a series of synthetic guanylhydrazones. Different human tumor cell lines, by including HCT-8 (colon carcinoma), MDA-MB-435 (melanoma) and SF-295 (glioblastoma) were continuous exposed to guanylhydrazone derivatives for 72 hours and growth inhibition of tumor cell lines and macrophages J774 was measured using tetrazolium salt (MTT) assay. Compounds 7, 11, 16 and 17 showed strong cytotoxic activity with IC50 values lower than 10 μmol L(-1) against four tumor cell lines. Among them, 7 was less toxic to non-tumor cells. Finally, obtained data suggest that guanylhydrazones may be regarded as potential lead compounds for the design of novel anticancer agents.

  18. Preliminary in vitro evaluation of the anti-proliferative activity of guanylhydrazone derivatives

    Directory of Open Access Journals (Sweden)

    França Paulo H. B.

    2016-03-01

    Full Text Available Guanylhydrazones have shown promising antitumor activity in preclinical tumor models in several studies. In this study, we aimed at evaluating the cytotoxic effect of a series of synthetic guanylhydrazones. Different human tumor cell lines, by including HCT-8 (colon carcinoma, MDA-MB-435 (melanoma and SF-295 (glioblastoma were continuous exposed to guanylhydrazone derivatives for 72 hours and growth inhibition of tumor cell lines and macrophages J774 was measured using tetrazolium salt (MTT assay. Compounds 7, 11, 16 and 17 showed strong cytotoxic activity with IC50 values lower than 10 μmol L−1 against four tumor cell lines. Among them, 7 was less toxic to non-tumor cells. Finally, obtained data suggest that guanylhydrazones may be regarded as potential lead compounds for the design of novel anticancer agents.

  19. Water-soluble derivatives of 25-OCH3-PPD and their anti-proliferative activities.

    Science.gov (United States)

    Zhou, Wu-Xi; Sun, Yuan-Yuan; Yuan, Wei-Hui; Zhao, Yu-Qing

    2017-05-01

    (20R)-25-Methoxyl-dammarane-3β,12β,20-triol (25-OCH 3 -PPD, AD-1) is a dammarane-type sapogenin showing anti-tumor potential. In the search for new anti-tumor agents with higher potency than our previously identified compound 25-OCH 3 -PPD, 11 novel sulfamic acid and diacid derivatives that could improve water solubility and contribute to good drug potency and pharmacokinetic profiles were designed and synthesized. Their in vitro anti-tumor activities in MCF-7, A-549, HCT-116, and BGC-823 cell lines and one normal cell line were tested by standard MTT assay. Results showed that compared with compound 25-OCH 3 -PPD, compounds 1, 4, and 5 exhibited higher cytotoxic activity on almost all cell lines, together with lower toxicity in the normal cell. In particular, compound 1 exhibited the best anti-tumor activity in the in vitro assays. The water solubility of 25-OCH 3 -PPD and its derivatives was tested and the results showed that the solubility of 25-OCH 3 -PPD sulfamic acid and diacid derivatives were better than that of 25-OCH 3 -PPD in water, which may provide valuable data for the research and development of new anti-tumor agents. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. Proliferative activity of endotheliocytes of growing capillaries of the rabbit cornea

    International Nuclear Information System (INIS)

    Gurina, O.Yu.; Mamontov, S.G.; Banin, V.V.

    1987-01-01

    The authors studied the intensity of DNA synthesis by cells of newly formed capillaries, growing in the rabbit cornea, after infliction of a silver nitrate burn and local application of colchicine. The intensity of capillary growth was investigated during stimulation and a combination of the burn with colchicine. Changes in activity of DNA synthesis by the endotheliocytes of newly formed capillaries during exposure throughout growth were also investigated. The intensity of cell proliferation was studied by measuring the incorporation of tritium-labelled thymidine into the endotheoiocyte nuclei

  1. Malignant Trigeminal Nerve Sheath Tumor and Anaplastic Astrocytoma Collision Tumor with High Proliferative Activity and Tumor Suppressor P53 Expression

    Directory of Open Access Journals (Sweden)

    Maher Kurdi

    2014-01-01

    Full Text Available Background. The synchronous development of two primary brain tumors of distinct cell of origin in close proximity or in contact with each other is extremely rare. We present the first case of collision tumor with two histological distinct tumors. Case Presentation. A 54-year-old woman presented with progressive atypical left facial pain and numbness for 8 months. MRI of the brain showed left middle cranial fossa heterogeneous mass extending into the infratemporal fossa. At surgery, a distinct but intermingled intra- and extradural tumor was demonstrated which was completely removed through left orbitozygomatic-temporal craniotomy. Histopathological examination showed that the tumor had two distinct components: malignant nerve sheath tumor of the trigeminal nerve and temporal lobe anaplastic astrocytoma. Proliferative activity and expressed tumor protein 53 (TP53 gene mutations were demonstrated in both tumors. Conclusions. We describe the first case of malignant trigeminal nerve sheath tumor (MTNST and anaplastic astrocytoma in collision and discuss the possible hypothesis of this rare occurrence. We propose that MTNST, with TP53 mutation, have participated in the formation of anaplastic astrocytoma, or vice versa.

  2. DNA Amplifications and Aneuploidy, High Proliferative Activity and Impaired Cell Cycle Control Characterize Breast Carcinomas with Poor Prognosis

    Directory of Open Access Journals (Sweden)

    Harald Blegen

    2003-01-01

    Full Text Available In order to explore whether specific cytogenetic abnormalities can be used to stratify tumors with a distinctly different clinical course, we performed comparative genomic hybridization (CGH of tumors from patients who were diagnosed with metastatic disease after an interval of less than 2 years or who remained free from distant metastases for more than 10 years. All patients presented with distant metastases after mastectomy indicating that none of the patients in this study was cured and free of remaining tumor cells. Tumors in the group of short‐term survivors showed a higher average number of chromosomal copy alterations compared to the long‐term survivors. Of note, the number of sub‐chromosomal high‐level copy number increases (amplifications was significantly increased in the group of short‐term survivors. In both short‐ and long‐term survivors recurrent chromosomal gains were mapped to chromosomes 1q, 4q, 8q, and 5p. Copy number changes that were more frequent in the group of short‐term survivors included gains of chromosome 3q, 9p, 11p and 11q and loss of 17p. Our results indicate that low‐ and high grade malignant breast adenocarcinomas are characterized by a specific pattern of chromosomal copy number changes. Furthermore, immunohistochemical evaluation of the expression levels of Ki‐67, p27KIP1, p21WAF1, p53, cyclin A and cyclin E revealed a correlation between increased proliferative activity and poor outcome.

  3. BYLINA AS A LITERARY GENRE

    Directory of Open Access Journals (Sweden)

    Olga V. Zakharova

    2015-11-01

    Full Text Available The bylina is a Russian epic song about the bogatyrs. Diff erent genre transformations of bylinas are known in folklore: prosaic narrations [pobyval’shchiny], bogatyr tales, legends about the bogatyrs, lubok tales about the feats of the bogatyrs and knights. In the early 19th  century, Russian literature was actively absorbing epic images and motives: the bogatyrs were turning into characters of novellas, literary tales, poems, novels, operas. Some poets and writers were attempting to develop the bylina as a literary genre. Their genre search was a  creative imitation of Th e Tale of Igor’s Campaign [“Slovo o polku Igoreve”] published in 1800 and in some cases of the Collection of Kirsha Danilov (1804. One of the first attempts was Gavrila R. Derzhavin’s work Dobrynya, Dramatic Musical Performance in Five Acts [“Dobrynya, teatral’noe predstavlenie s muzykoyu, v pyati deystviyakh”, 1804]. Glorifying the idea of the state, the poet composes a work where epic and literary characters act and the plot is derived not only from bylinas and tales, but also from chivalric novels. In Stepan S. Andreev’s poem Levsil, a Russian Bogatyr [“Levsil, russkiy bogatyr’”, 1807] the hero is not only a folkloric (epic and fabulous character, but also a literary one. Alexander F. Veltman’s novel Koshchei the Immortal. A Bylina of the Old Times [“Koshchey bessmertnyy. Bylina starogo vremeni”, 1833] was an ingenious genre experiment. The word ‘bylina’ was used in its title in  the literary genre meaning for the fi rst time ever. The genre of Easter novella Ilya Muromets. A Tale from the Rus’ of the Bogatyrs [“Il’ya Muromets. Skazka Rusi bogatyrskyi”, 1836] by Vladimir I. Dahl emerged from a complicated interaction of the tale, the bylina, the Old Russian novella and the hagiography. The literary transformations of folkloric genre stemmed from the authors’ imaginative need to create a national and historical myth

  4. Chronic Proliferative Dermatitis in Mice: NFκB Activation Autoinflammatory Disease

    Directory of Open Access Journals (Sweden)

    Yanhua Liang

    2011-01-01

    Full Text Available Autoinflammatory diseases are a heterogeneous group of congenital diseases characterized by the presence of recurrent inflammation, in the absence of infectious agents, detectable autoantibodies or antigen-specific autoreactive T-cells. SHARPIN deficient mice presents multiorgan chronic inflammation without known autoantibodies or autoreactive T-cells, designated Sharpincpdm. Histological studies demonstrated epidermal hyperproliferation, Th-2 inflammation, and keratinocyte apoptosis in this mutant. The mutant mice have decreased behavioral mobility, slower growth, and loss of body weight. Epidermal thickness and mitotic epidermal cells increase along with disease development. K5/K14 expression is distributed through all layers of epidermis, along with K6 expression in interfollicular epidermis, suggesting epidermal hyperproliferation. K1/K10 is only detectable in outer layers of spinosum epidermis, reflecting accelerated keratinocyte migration. Alpha smooth muscle actin is overexpressed in skin blood vessels, which may release the elevated white blood cells to dermis. CD3+CD45+ cells and granulocytes, especially eosinophils and mast cells, aggregate in the mutant skin. TUNEL assay, together with Annexin-V/propidium iodide FACS analysis, confirmed the increase of apoptotic keratinocytes in skin. These data validate and provide new lines of evidence of the proliferation-inflammation-apoptosis triad in Sharpincpdm mice, an NFκB activation autoinflammatory disease.

  5. In vitro anti-proliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb

    OpenAIRE

    Landa, P. (Přemysl); Skálová, L.; Boušová, I.; Kutil, Z. (Zsófia); Langhansová, L. (Lenka); Lou, J.D.; Vaněk, T. (Tomáš)

    2014-01-01

    The aim of this study was to evaluate in vitro anti-proliferative (tested on MCF-7, MDA-MB-231, and MCF-10A cell lines) and anti-inflammatory (evaluated as inhibition of prostaglandin E2 synthesis catalyzed by cyclooxygenase-2) effect of various extracts from Vaccinium bracteatum leaves and fruits. The highest anti-proliferative effect possessed leaf dichloromethane extract with IC50 values ranging from 93 to 198 mug/mL. In the case of cyclooxygenase-2 inhibition, n-hexane, dichloromethane, a...

  6. Influence of constant, alternating and cyclotron low-intensity electromagnetic fields on fibroblast proliferative activity in vitro.

    Science.gov (United States)

    Afinogenov, Gennadi; Afinogenova, Anna; Kalinin, Andrey

    2009-12-16

    Available data allow assuming the presence of stimulation of reparative processes under influence of low-intensity electromagnetic field, commensurable with a magnetic field of the Earth. Research of effects of low-intensity electromagnetic fields on fibroblast proliferative activity in human lungs in cell culture was performed.The influence of a constant electromagnetic field, an alternating electromagnetic field by frequency of 50 Hz and cyclotron electromagnetic field with identical intensity for all kinds of fields - 80 mcTl - on value of cellular mass and a correlation of live and dead cells in culture is investigated in three series of experiments. We used the universal electromagnetic radiator generating all three kinds of fields and supplied by a magnetometer which allows measuring the intensity of accurate within 0.1 mcTl including taking into account the Earth's magnetic field intensity.The peak value for stimulation cellular proliferation in the present experiences was two-hour influence by any of the specified kinds of electromagnetic fields. The irradiation by cyclotron electromagnetic field conducts positive dynamics in growth of live cells (up to 206+/-22%) and decreases the number of dead cells (down to 31+/-6%). Application of cyclotron magnetic fields promoted creation of optimum conditions for proliferation. As a result of researches we observed the reliable 30% increase of nitro-tetrazolium index (in nitro-tetrazolium blue test) after irradiation by cyclotron electromagnetic field in experience that testifies to strengthening of the cell breathing of living cells.In our opinion, it is necessary to pay attention not only to a pure gain of cells, but also to reduction of number dead cells that can be criterion of creation of optimum conditions for their specific development and valuable functioning.

  7. Chromatographic analysis, anti-proliferative and radical scavenging activity of Pinus wallichina essential oil growing in high altitude areas of Kashmir, India.

    Science.gov (United States)

    Yousuf Dar, Mohd; Shah, Wajaht A; Mubashir, Sofi; Rather, Manzoor A

    2012-10-15

    To evaluate the in vitro anti-proliferative and radical scavenging properties of the essential oil and its fractions and to determine the chemo-type of P. wallichiana essential oil. Pinus wallichiana oil was extracted by hydro-distillation and fractionated by silica gel column chromatography method. The oil and its fractions were analyzed by Gas chromatography, Gas chromatography-mass spectrometry and (13)C NMR. Different concentrations of oil 12.5, 25, 50 and 100μg/ml and single concentration 50μg/ml of its fractions B(1), B(2), A(2), G(2), Uk(13) and I(2) were evaluated for its anti-proliferative activity by in vitro {3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide} assay against human monocyte, lung carcinoma, liver adenocarcinoma, prostate and ovarian carcinoma, while as the radical scavenging activity was evaluated by different in vitro DPPH assays. The analyses indicated the presence of 17 constituents with β-pinene (46.8%) and α-pinene (25.2%) as major constituents. The oil and its fractions showed significant anti-proliferative activity. The radical scavenging activity also showed good results. The oil could be used as a drug to control the diseases like cancer, cirrhosis and arteriosclerosis, caused by reactive oxygen species. Copyright © 2012 Elsevier GmbH. All rights reserved.

  8. Korean Ginseng Berry Fermented by Mycotoxin Non-producing Aspergillus niger and Aspergillus oryzae: Ginsenoside Analyses and Anti-proliferative Activities.

    Science.gov (United States)

    Li, Zhipeng; Ahn, Hyung Jin; Kim, Nam Yeon; Lee, Yu Na; Ji, Geun Eog

    2016-01-01

    To transform ginsenosides, Korean ginseng berry (KGB) was fermented by mycotoxin non-producing Aspergillus niger and Aspergillus oryzae. Changes of ginsenoside profile and anti-proliferative activities were observed. Results showed that A. niger tended to efficiently transform protopanaxadiol (PPD) type ginsenosides such as Rb1, Rb2, Rd to compound K while A. oryzae tended to efficiently transform protopanaxatriol (PPT) type ginsenoside Re to Rh1 via Rg1. Butanol extracts of fermented KGB showed high cytotoxicity on human adenocarcinoma HT-29 cell line and hepatocellular carcinoma HepG2 cell line while that of unfermented KGB showed little. The minimum effective concentration of niger-fermented KGB was less than 2.5 µg/mL while that of oryzae-fermented KGB was about 5 µg/mL. As A. niger is more inclined to transform PPD type ginsenosides, niger-fermented KGB showed stronger anti-proliferative activity than oryzae-fermented KGB.

  9. The prognostic value of oncogenic antigen 519 (OA-519) expression and proliferative activity detected by antibody MIB-1 in node-negative breast cancer

    DEFF Research Database (Denmark)

    Jensen, V; Ladekarl, M; Holm-Nielsen, P

    1995-01-01

    The prognostic value of oncogenic antigen 519 (OA-519) expression and tumour proliferative activity was evaluated in a retrospective series of 118 patients with low-risk breast cancer. Low risk was defined as negative axillary nodes, tumour diameter histological evidence...... analysis, both the MIB-1 index and OA-519 expression were of independent prognostic value (2p breast cancer who might benefit from adjuvant therapy....

  10. Cytosol cathepsin-D content and proliferative activity of human breast cancer. The Comitato Italiano per il Controllo di Qualita del Laboratorio in Oncologia.

    Science.gov (United States)

    Paradiso, A; Mangia, A; Correale, M; Abbate, I; Ferri, G; Piffanelli, A; Catozzi, L; Amadori, D; Riccobon, A; De Lena, M

    1992-01-01

    Mitogenic properties have been demonstrated in vitro for the lysosomal acidic protease cathepsin-D (cath-D). We investigated possible relationships between cath-D cytosol cell content and tumor proliferative activity in a series of 129 operable breast cancer patients. For total cytosol cath-D evaluation, a solid phase two-site immunoradiometric assay was utilized on tumor cell cytosol obtained for hormone receptor assay (DCC method). The percentage of S-phase cells was analyzed by 3H-thymidine autoradiographic assay. Median 3H-thymidine Labeling Index (3H-Tdr-LI) of the series was 2.7%; median cath-D content resulted 57 pmol/mg of protein cytosol and was significantly higher in node-positive with respect to the node-negative subgroup (p < 0.03). When classified in low, intermediate or high tumor cath-D content and slow or fast proliferative activity (cut-off: median values of the series), no significant agreement was found between the two variables. Statistical analysis, however, showed that a significant inverse correlation existed in node positive tumors between cath-D and 3H-Tdr-LI values which was even more evident in N-positive high estrogen receptor-positive (ER+) cases (coefficient of correlation = 0.6828; p = 0.0001). Cytosol cath-D content cannot be generally proposed as a direct marker of proliferative activity for operable breast cancer.

  11. Immunoregulatory activities of human immunodeficiency virus (HIV) proteins: Effect of HIV recombinant and synthetic peptides on immunoglobulin synthesis and proliferative responses by normal lymphocytes

    International Nuclear Information System (INIS)

    Nair, M.P.N.; Pottathil, R.; Heimer, E.P.; Schwartz, S.A.

    1988-01-01

    Recombinant and synthetic peptides corresponding to envelope proteins of the human immunodeficiency virus (HIV) were examined for their effects on the activities of lymphocytes from normal donors in vitro. Although lymphocytes cultured with env-gag peptides produced significant amounts of IgG, addition of env-gag peptides to a pokeweed mitogen-induced B-cell activation system resulted in suppression of immunoglobulin synthesis by normal lymphocytes. Recombinant antigens, env-gag and env-80 dihydrofolate reductase (DHFR), produced a substantial proliferative response by peripheral blood mononuclear cells (PBMC) as determined by [ 3 H]thymidine incorporation. PBMC precultured with HIV synthetic peptide env 578-608 also manifested significant proliferative responses as compared to control cultures. CD3 + lymphocytes precultured with recombinant HIV antigens, env-gag and env-80 DHFR, and synthetic HIV peptide, env 487-511, showed moderate but significant proliferative responses. Both recombinant antigens and synthetic peptides also produced a dose-dependent stimulatory effect on proliferation by CD3 - lymphocytes. These studies demonstrate that recombinant and synthetic peptides of the HIV genome express immunoregulatory T- and B-cell epitopes. Identification of unique HIV epitopes with immunogenic and immunoregulatory activities is necessary for the development of an effective vaccine against HIV infection

  12. Levels of Literary Meaning

    DEFF Research Database (Denmark)

    Klausen, Søren Harnow

    2017-01-01

    I argue that intentionalist theories of meaning and interpretation, like those of Hirsch and Juhl, have been insufficiently attentive to the different levels of authorial intention that are operative in literary works. By countenancing intentions on different levels – ranging from simple semantic...

  13. Changes in retinal venular oxygen saturation predict activity of proliferative diabetic retinopathy 3 months after panretinal photocoagulation.

    Science.gov (United States)

    Torp, Thomas Lee; Kawasaki, Ryo; Wong, Tien Yin; Peto, Tunde; Grauslund, Jakob

    2018-03-01

    Proliferative diabetic retinopathy (PDR) is a severe blinding condition. We investigated whether retinal metabolism, measured by retinal oximetry, may predict PDR activity after panretinal laser photocoagulation (PRP). We performed a prospective, interventional, clinical study of patients with treatment-naive PDR. Wide-field fluorescein angiography (OPTOS, Optomap) and global and focal retinal oximetry (Oxymap T1) were performed at baseline (BL), and 3 months (3M) after PRP. Angiographic findings were used to divide patients according to progression or non-progression of PDR after PRP. We evaluated differences in global and focal retinal oxygen saturation between patients with and without progression of PDR after PRP treatment. We included 45 eyes of 37 patients (median age and duration of diabetes were 51.6 and 20 years). Eyes with progression of PDR developed a higher retinal venous oxygen saturation than eyes with non-progression at 3M (global: +5.9% (95% CI -1.5 to 12.9), focal: +5.4%, (95% CI -4.1 to 14.8)). Likewise, progression of PDR was associated with a lower arteriovenular (AV) oxygen difference between BL and 3M (global: -6.1%, (95% CI -13.4 to -1.4), focal: -4.5% (95% CI -12.1 to 3.2)). In a multiple logistic regression model, increment in global retinal venular oxygen saturation (OR 1.30 per 1%-point increment, p=0.017) and decrement in AV oxygen saturation difference (OR 0.72 per 1%-point increment, p=0.016) at 3M independently predicted progression of PDR. Development of higher retinal venular and lower AV global oxygen saturation independently predicts progression of PDR despite standard PRP and might be a potential non-invasive marker of angiogenic disease activity. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  14. Anti-proliferative and mutagenic activities of aqueous and methanol extracts of leaves from Pereskia bleo (Kunth) DC (Cactaceae).

    Science.gov (United States)

    Er, Hui Meng; Cheng, En-Hsiang; Radhakrishnan, Ammu Kutty

    2007-09-25

    The anti-proliferative effects of the aqueous and methanol extracts of leaves of Pereskia bleo (Kunth) DC (Cactaceae) against a mouse mammary cancer cell line (4T1) and a normal mouse fibroblast cell line (NIH/3T3) were evaluated under an optimal (in culture medium containing 10% foetal bovine serum (FBS)) and a sub-optimal (in culture medium containing 0.5% FBS) conditions. Under the optimal condition, the aqueous extract showed a significant (pCactaceae) do not have appreciable anti-proliferative effect on the 4T1 and NIH/3T3 cells as the EC(50) values obtained are greater than 50 microg/mL when tested under optimal culture condition. Moreover, the aqueous extract may form mutagenic compound(s) upon the metabolisation by liver enzymes.

  15. Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon

    Directory of Open Access Journals (Sweden)

    Jan Tauchen

    Full Text Available ABSTRACT Among 23 extracts of medicinal and edible plants tested, Mauritia flexuosa L.f., Arecaceae, showed significant antioxidant ability (DPPH and ORAC = 1062.9 and 645.9 ± 51.4 µg TE/mg extract, respectively, while Annona montana Macfad., Annonaceae, demonstrated the most promising anti-proliferative effect (IC50 for Hep-G2 and HT-29 = 2.7 and 9.0 µg/ml, respectively. However, combinatory antioxidant/anti-proliferative effect was only detected in Oenocarpus bataua Mart., Arecaceae (DPPH = 903.8 and ORAC = 1024 µg TE/mg extract; IC50 for Hep-G2 and HT-29 at 102.6 and 38.8 µg/ml, respectively and Inga edulis Mart., Fabaceae (DPPH = 337.0 and ORAC = 795.7 µg TE/mg extract; IC50 for Hep-G2 and HT-29 at 36.3 and 57.9 µg/ml, respectively. Phenolic content was positively correlated with antioxidant potential, however not with anti-proliferative effect. None of these extracts possessed toxicity towards normal foetal lung cells, suggesting their possible use in development of novel plant-based agents with preventive and/or therapeutic action against oxidative stress-related diseases.

  16. Noninvasive Evaluation of Cellular Proliferative Activity in Brain Neurogenic Regions in Rats under Depression and Treatment by Enhanced [18F]FLT-PET Imaging.

    Science.gov (United States)

    Tamura, Yasuhisa; Takahashi, Kayo; Takata, Kumi; Eguchi, Asami; Yamato, Masanori; Kume, Satoshi; Nakano, Masayuki; Watanabe, Yasuyoshi; Kataoka, Yosky

    2016-08-03

    Neural stem cells in two neurogenic regions, the subventricular zone and the subgranular zone (SGZ) of the hippocampal dentate gyrus, can divide and produce new neurons throughout life. Hippocampal neurogenesis is related to emotions, including depression/anxiety, and the therapeutic effects of antidepressants, as well as learning and memory. The establishment of in vivo imaging for proliferative activity of neural stem cells in the SGZ might be used to diagnose depression and to monitor the therapeutic efficacy of antidepressants. Positron emission tomography (PET) imaging with 3'-deoxy-3'-[(18)F]fluoro-l-thymidine ([(18)F]FLT) has been studied to allow visualization of proliferative activity in two neurogenic regions of adult mammals; however, the PET imaging has not been widely used because of lower accumulation of [(18)F]FLT, which does not allow quantitative assessment of the decline in cellular proliferative activity in the SGZ under the condition of depression. We report the establishment of an enhanced PET imaging method with [(18)F]FLT combined with probenecid, an inhibitor of drug transporters at the blood-brain barrier, which can allow the quantitative visualization of neurogenic activity in rats. Enhanced PET imaging allowed us to evaluate reduced cell proliferation in the SGZ of rats with corticosterone-induced depression, and further the recovery of proliferative activity in rats under treatment with antidepressants. This enhanced [(18)F]FLT-PET imaging technique with probenecid can be used to assess the dynamic alteration of neurogenic activity in the adult mammalian brain and may also provide a means for objective diagnosis of depression and monitoring of the therapeutic effect of antidepressant treatment. Adult hippocampal neurogenesis may play a role in major depression and antidepressant therapy. Establishment of in vivo imaging for hippocampal neurogenic activity may be useful to diagnose depression and monitor the therapeutic efficacy of

  17. "Je n'aimais pas ce public..." Une pratique active du texte litteraire ("I Didn't Like This Public..." An Active Exercise with the Literary Text).

    Science.gov (United States)

    Dell'Utri, Salvatore

    1990-01-01

    A series of French language classroom exercises to be used over four class sessions applies principles of semiotics to literary textual analysis. The session themes include decoding and interpreting, reconstructing meaning, sociocultural connotations in the text, and sense of time and space. (MSE)

  18. Georges Perec's literary staging

    Directory of Open Access Journals (Sweden)

    Ewelina Woźniak-Czech

    2017-12-01

    Full Text Available The purpose of this sketch to present Georges Perec’s work in the context of drama. As Perec wrote just one play for the theater, it’s hard to call him a dramatist. However, it is easy to see that all the literary tricks he uses in his works are a part of a well-thought-out game. The author of Life a User’s Manual employs and interweaves various literary conventions, prompts dialogue between his own works and draws the reader into the very center of his tricks, nuances and simulations. Perec’s writing could be deemed a pure act of dramatization, where the author himself, to some extent, takes on the role of director, making his audience not so much the recipients of his texts but the actors performing them.

  19. Cervantes and Literary Preceptive

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Garrido Gallardo

    2014-12-01

    Full Text Available The historiography of literary culture often links the Quixote and, by extension, the work of Cervantes with the Preceptive, a theme that perseveringly appears in the curricular studies from the late seventeenth century to the early twentieth century. Not being literary Preceptive more than a normative version of the Poetics and Rhetoric, this paper examines the possible relationship of Cervantes’ work with the normative aspect of both disciplines, such as they flourished in the sixteenth century and early seventeenth century. The symptomatic example of Juan de la Cueva’s El Ejemplar poético (1606 is explored and the itinerary of three possible relationships is followed: the acceptance or rejection of the current preceptive by the author, the presumed adoption of the preceptive as a set of generative rules of its own creation and the use of Cervantes’ production as an example and lesson for the future preceptive.

  20. Literary Voices in Dubliners

    OpenAIRE

    Duech, Lorie-Anne

    2017-01-01

    Critics have already pointed out the importance of Joyce's use of quotation, allusion and parody, especially in his later work. The names of Flaubert, Oscar Wilde and Shakespeare have long been associated with Joyce's writing. This is the type of literary association that places Joyce within "tradition" and "the historical sense" which involves, as T.S. Eliot explains, "a perception, not only of the pastness of the past, but of its presence." Joyce's use of subtexts not only reveals his tende...

  1. Proliferative Activity of Mammary Carcinoma Cells by AgNOR Count in C3H mice Receiving Ethanol Extract of Sponge Haliclona sp

    Science.gov (United States)

    Sijabat, Lanceria; Susilaningsih, Neni; Trianto, Agus; Murwani, Retno

    2018-02-01

    Quantification of argyrophilic nucleolar organizer region (AgNORs) was considered as one of markers of proliferative activity of cancer cells. Sponge Haliclona sp extract contains anticancer bioactive compounds and our previous study showed that the extract was able to improve histological grade of induced mammary adenocarcinoma in mice. The following research was conducted to study the extract administration on the proliferative activity of the carcinoma cells represented by AgNOR count in mice. This experimental study applied post test only control group design. Twenty C3H mice were divided into four groups namely C (control), H1, H2 and H3. Each group was given 0, 0.15, 1.5, and 15 mg Haliclona sp extract respectively. After three weeks of extract administration, mice were inoculated with breast cancer cells from donor mice. The extract administration were continued for another three weeks. AgNOR count was performed on tumor sections and expressed as mean of AgNOR (mAgNOR) and percentage of AgNOR (pAgNOR). Means of mAgNOR in C, H1, H2 and H3 were 4.070, 3.195, 3.450, and 3.190 respectively. Means of pAgNOR in C, H1, H2 and H3 were 34,40, 25,40, 38,40 and 19,80 respectively. The lowest means of mAgNOR and pAgNOR which is an indication of lower proliferative activity of the cancer cells was found in H3. However no significant difference can be found among treatment groups (p>0.05). Using AgNOR count, the ethanol extract of Haliclona sp could not show significant reduction in proliferation of mammary carcinoma cells of C3H mice. This finding support the view that AgNOR alone could not be used to determine pathology of cancer cells.

  2. Uric acid stimulates proliferative pathways in vascular smooth muscle cells through the activation of p38 MAPK, p44/42 MAPK and PDGFRβ.

    Science.gov (United States)

    Kırça, M; Oğuz, N; Çetin, A; Uzuner, F; Yeşilkaya, A

    2017-04-01

    Hyperuricemia and angiotensin II (Ang II) may have a pathogenetic role in the development of hypertension and atherosclerosis as well as cardiovascular disease (CVD) and its prognosis. The purpose of this study was to investigate whether uric acid can induce proliferative pathways of vascular smooth muscle cell (VSMC) that are thought to be responsible for the development of CVD. The phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK), p44/42 mitogen-activated protein kinase (p44/42 MAPK) and platelet-derived growth factor receptor β (PDGFRβ) was measured by Elisa and Western blot techniques to determine the activation of proliferative pathways in primary cultured VSMCs from rat aorta. Results demonstrated that uric acid can stimulate p38 MAPK, p44/42 MAPK and PDGFRβ phosphorylation in a time- and concentration-dependent manner. Furthermore, treatment of VSMCs with the angiotensin II type I receptor (AT1R) inhibitor losartan suppressed p38 MAPK and p44/42 MAPK induction by uric acid. The stimulatory effect of uric acid on p38 MAPK was higher compared to that of Ang II. The results of this study show for the first time that uric acid-induced PDGFRβ phosphorylation plays a crucial role in the development of CVDs and that elevated uric acid levels could be a potential therapeutical target in CVD patients.

  3. An Afropolitan literary aesthetics?

    DEFF Research Database (Denmark)

    Rahbek, Ulla; Knudsen, Eva Rask

    2017-01-01

    This article discusses what the authors call an emerging Afropolitan aesthetics. Through an exploration of recurring stylistic features, the article focuses particularly on the trope of a mobility-induced anxiety that entwines place and self. The ontological and affective troping of return...... and of self-understanding and the contemporary signification of Africa as a complex place of relocation and reconnection are explored in discussions of literary characters in Taiye Selasi’s Ghana Must Go (2013), Yvonne Owuor’s Dust (2014), Sefi Atta’s A Bit of Difference (2013) and Chimamanda Ngozi Adichie...

  4. Anti-proliferative activity of 2,6-dichloro-9- or 7-(ethoxycarbonylmethyl)-9H- or 7H-purines against several human solid tumour cell lines.

    Science.gov (United States)

    Morales, Fátima; Ramírez, Alberto; Conejo-García, Ana; Morata, Cynthia; Marchal, Juan A; Campos, Joaquín M

    2014-04-09

    As leads we took several benzo-fused seven- and six-membered scaffolds linked to the pyrimidine or purine moieties with notable anti-proliferative activity against human breast, colon and melanoma cancerous cell lines. We then decided to maintain the double-ringed nitrogenous bases and change the other components to the ethyl acetate moiety. This way six purine and two 5-fluorouracil derivatives were obtained and evaluated against the MCF-7, HCT-116, A-375 and G-361 cancer cell lines. Two QSARs are obtained between the anti-proliferative IC₅₀ values for compounds 26-33 and the clog P against the melanoma cell lines A-375 and G-361. Our results show that two of the analogues [ethyl 2-(2,6-dichloro-9H- or 7H-purine-9- or 7-yl)acetates (30 and 33, respectively)] are potent cytotoxic agents against all the tumour cell lines assayed, showing single-digit micromolar IC₅₀ values. This exemplifies the potential of our previously reported purine compounds to qualify as lead structures for medicinal chemistry campaigns, affording simplified analogues easy to synthesize and with a noteworthy bioactivity. The selective activity of 30 and 33 against the melanoma cell line A-375, via apoptosis, supposes a great advantage for a future therapeutic use. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  5. A comparative study of proliferative activity and tumor stage of pregnancy-associated melanoma (PAM) and non-PAM in gestational age women.

    Science.gov (United States)

    Merkel, Emily A; Martini, Mary C; Amin, Sapna M; Yélamos, Oriol; Lee, Christina Y; Sholl, Lauren M; Rademaker, Alfred W; Guitart, Joan; Gerami, Pedram

    2016-01-01

    The influence of pregnancy on the development, progression, and prognosis of melanoma is controversial. We sought to compare clinical characteristics, histologic features, and proliferative activity in pregnancy-associated melanoma (PAM) and melanoma in nonpregnant women of reproductive age (non-PAM). In this retrospective cohort study, we reviewed medical records and pathology reports from women given a diagnosis of melanoma between 2006 and 2015. We also examined tumor proliferation rates using mitotic count and 2 immunohistochemical markers of proliferation, phosphohistone H3 and Ki-67. In 50 PAM and 122 non-PAM cases, a diagnosis of melanoma in situ was associated with PAM. Among invasive melanomas, there was no difference in proliferative activity between groups. Pregnancy status was also not associated with age at diagnosis, tumor site, Breslow depth, Clark level, ulceration, or overall stage. This was a retrospective study with a small sample size of mostly patients with early-stage melanoma. In our study of primarily early-stage melanoma, pregnancy did not have a significant impact on tumor proliferation. Particularly for patients given a diagnosis of stage I melanoma who are undergoing close surveillance, a history of PAM should not outweigh traditional factors, such as advanced maternal age, in planning future pregnancies. Copyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  6. Proliferative retinopathy predicts nephropathy

    DEFF Research Database (Denmark)

    Karlberg, Charlotte; Falk, Christine; Green, Anders

    2012-01-01

    We wanted to examine proliferative retinopathy as a marker of incident nephropathy in a 25-year follow-up study of a population-based cohort of Danish type 1 diabetic patients and to examine cross-sectional associations between nephropathy and retinopathy in long-term surviving patients of the same...... cohort. All type 1 diabetic patients from Fyn County, Denmark, were identified as of 1 July 1973. One hundred and eighty four patients were examined in 1981-1982 (baseline) and in 2007-2008 (follow-up). The level of retinopathy was graded by ophthalmoscopy at baseline and nine-field digital colour fundus...... and proliferative retinopathy, respectively. In conclusion, proliferative retinopathy is an independent marker of long-term nephropathy in type 1 diabetes. Upcoming studies should examine whether these microvascular complications are also causally linked in type 1 diabetes....

  7. A peroxisome proliferator-activated receptor ligand MCC-555 imparts anti-proliferative response in pancreatic cancer cells by PPARgamma-independent up-regulation of KLF4

    Energy Technology Data Exchange (ETDEWEB)

    Min, Kyung-Won [Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 (United States); Zhang, Xiaobo [Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 (United States); College of Animal Science and Technology, Northwest A and F University, Yangling, Shaanxi, 712100 (China); Imchen, Temjenmongla [Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 (United States); Baek, Seung Joon, E-mail: sbaek2@utk.edu [Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 (United States)

    2012-09-01

    MCC-555 is a novel PPARα/γ dual ligand of the thiazolidinedione class and was recently developed as an anti-diabetic drug with unique properties. MCC-555 also has anti-proliferative activity through growth inhibition and apoptosis induction in several cancer cell types. Our group has shown that MCC-555 targets several proteins in colorectal tumorigenesis including nonsteroidal anti-inflammatory drug (NSAID)-activated gene (NAG-1) which plays an important role in chemoprevention responsible for chemopreventive compounds. NAG-1 is a member of the TGF-β superfamily and is involved in tumor progression and development; however, NAG-1's roles in pancreatic cancer have not been studied. In this report, we found that MCC-555 alters not only NAG-1 expression, but also p21 and cyclin D1 expression. NAG-1 and p21 expression was not blocked by PPARγ-specific antagonist GW9662, suggesting that MCC-555-induced NAG-1 and p21 expression is independent of PPARγ activation. However, decreasing cyclin D1 by MCC-555 seems to be affected by PPARγ activation. Further, we found that the GC box located in the NAG-1 promoter play an important role in NAG-1 transactivation by MCC-555. Subsequently, we screened several transcription factors that may bind to the GC box region in the NAG-1 promoter and found that KLF4 potentially binds to this region. Expression of KLF4 precedes NAG-1 and p21 expression in the presence of MCC-555, whereas blocking KLF4 expression using specific KLF4 siRNA showed that both NAG-1 and p21 expression by MCC-555 was blocked. In conclusion, MCC-555's actions on anti-proliferation involve both PPARγ-dependent and -independent pathways, thereby enhancing anti-tumorigenesis in pancreatic cancer cells. -- Highlights: ► PPARα/γ ligand MCC-555 exhibits anti-proliferative activity in pancreatic cancer cells. ► MCC-555 affects KLF4 expression following by NAG-1 and p21 expression in a PPARγ independent manner. ► MCC-555 also affects cyclin D1 down

  8. A peroxisome proliferator-activated receptor ligand MCC-555 imparts anti-proliferative response in pancreatic cancer cells by PPARgamma-independent up-regulation of KLF4

    International Nuclear Information System (INIS)

    Min, Kyung-Won; Zhang, Xiaobo; Imchen, Temjenmongla; Baek, Seung Joon

    2012-01-01

    MCC-555 is a novel PPARα/γ dual ligand of the thiazolidinedione class and was recently developed as an anti-diabetic drug with unique properties. MCC-555 also has anti-proliferative activity through growth inhibition and apoptosis induction in several cancer cell types. Our group has shown that MCC-555 targets several proteins in colorectal tumorigenesis including nonsteroidal anti-inflammatory drug (NSAID)-activated gene (NAG-1) which plays an important role in chemoprevention responsible for chemopreventive compounds. NAG-1 is a member of the TGF-β superfamily and is involved in tumor progression and development; however, NAG-1's roles in pancreatic cancer have not been studied. In this report, we found that MCC-555 alters not only NAG-1 expression, but also p21 and cyclin D1 expression. NAG-1 and p21 expression was not blocked by PPARγ-specific antagonist GW9662, suggesting that MCC-555-induced NAG-1 and p21 expression is independent of PPARγ activation. However, decreasing cyclin D1 by MCC-555 seems to be affected by PPARγ activation. Further, we found that the GC box located in the NAG-1 promoter play an important role in NAG-1 transactivation by MCC-555. Subsequently, we screened several transcription factors that may bind to the GC box region in the NAG-1 promoter and found that KLF4 potentially binds to this region. Expression of KLF4 precedes NAG-1 and p21 expression in the presence of MCC-555, whereas blocking KLF4 expression using specific KLF4 siRNA showed that both NAG-1 and p21 expression by MCC-555 was blocked. In conclusion, MCC-555's actions on anti-proliferation involve both PPARγ-dependent and -independent pathways, thereby enhancing anti-tumorigenesis in pancreatic cancer cells. -- Highlights: ► PPARα/γ ligand MCC-555 exhibits anti-proliferative activity in pancreatic cancer cells. ► MCC-555 affects KLF4 expression following by NAG-1 and p21 expression in a PPARγ independent manner. ► MCC-555 also affects cyclin D1 down

  9. Intersections : Amazigh (Berber) Literary Space

    NARCIS (Netherlands)

    Merolla, D.; Bratt, K. R.; Elbousty, Y.; Steward, D.J.

    2014-01-01

    The interaction of artistic productions with several languages, literary markets and media is crucial in the Amazigh literary space. Focusing on writers who use the Amazigh (Berber) language, this study addresses contemporary directions in Moroccan Amazigh (Berber) artistic works set against the

  10. Technology Toolkit: Literary Road Trip

    Science.gov (United States)

    Hayes, Sandy

    2007-01-01

    Hayes recognizes the value of connections kids make when authors and settings strike a familiar note. She invites readers to participate in a new event at this year's NCTE Annual Convention in New York City: The 21st-Century Literary Map Project gallery, where attendees are encouraged to examine affiliates' literary maps, see digital or…

  11. Cell structure and proliferative activity of organ cultures of normal embryonic lung tissue of mice resistant (C57BL) and predisposed (A) to lung tumors

    International Nuclear Information System (INIS)

    Kolesnichenko, T.S.; Gor'kova, T.G.

    1985-01-01

    Local factors such as proliferative activity and the numerical ratio between epithelial and mesenchymal cells, and also the character of interaction between the tissue components in ontogeny may play an important role in the realization of sensitivity of mice of a particular line to the development of lung tumors. These characteristics of lung tissue in mice of lines A and C57BL are investigated under normal conditions and during induced carcinogenesis. Results are given of a comparative study of the relative numbers of epithelial and mesenchymal cells in organ cultures of embryonic lungs. 3 H-thymidine was added to the cultures on the 14th day of the experiment in a concentration of 1 microCi/m1 medium. An autoradiographic study of the cultures was performed

  12. Proliferative activity (MIB-1 index) is an independent prognostic parameter in patients with high-grade soft tissue sarcomas of subtypes other than malignant fibrous histiocytomas

    DEFF Research Database (Denmark)

    Jensen, V; Sørensen, Flemming Brandt; Bentzen, S M

    1998-01-01

    . The proliferative activity was assessed by use of the monoclonal antibody MIB-1 and evaluated in multiple, random systematic sampled fields of vision. The percentage of proliferating cells (the MIB-1 index) ranged between 1% and 85% (median 12%). A significant increase in mean MIB-1 index was seen with increasing...... histological malignancy grade. Variation in the incidence of p53 accumulation and bcl-2 positivity among different histological subtypes was observed. p53 accumulation was frequent in synovial sarcomas and leiomyo- and rhabdomyosarcomas, whereas bcl-2 preferentially was expressed in synovial sarcomas....... Univariate analysis identified patient age, tumour size, histological grade of malignancy, MIB-1 index and p53 accumulation as significant prognostic parameters. Multivariate Cox analysis, including tests for interaction terms between histological subtypes and MIB-1 index, showed independent prognostic...

  13. The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes

    International Nuclear Information System (INIS)

    Thomas, Maria; Bayha, Christine; Klein, Kathrin; Müller, Simon; Weiss, Thomas S.; Schwab, Matthias; Zanger, Ulrich M.

    2015-01-01

    The peroxisome proliferator-activated receptor alpha (PPARα) controls lipid/energy homeostasis and inflammatory responses. The truncated splice variant PPARα-tr was suggested to exert a dominant negative function despite being unable to bind consensus PPARα DNA response elements. The distribution and variability factor of each PPARα variant were assessed in the well-characterized cohort of human liver samples (N = 150) on the mRNA and protein levels. Specific siRNA-mediated downregulation of each transcript as well as specific overexpression with subsequent qRT-PCR analysis of downstream genes was used for investigation of specific functional roles of PPARα-wt and PPARα-tr forms in primary human hepatocytes. Bioinformatic analyses of genome-wide liver expression profiling data suggested a possible role of PPARα-tr in downregulating proliferative and pro-inflammatory genes. Specific gene silencing of both forms in primary human hepatocytes showed that induction of metabolic PPARα-target genes by agonist WY14,643 was prevented by PPARα-wt knock-down but neither prevented nor augmented by PPARα-tr knock-down. WY14,643 treatment did not induce proliferative genes including MYC, CDK1, and PCNA, and knock-down of PPARα-wt had no effect, while PPARα-tr knock-down caused up to 3-fold induction of these genes. Similarly, induction of pro-inflammatory genes IL1B, PTGS2, and CCL2 by IL-6 was augmented by knock-down of PPARα-tr but not of PPARα-wt. In contrast to human proliferative genes, orthologous mouse genes were readily inducible by WY14,643 in PPARα-tr non-expressing AML12 mouse hepatocytes. Induction was augmented by overexpression of PPARα-wt and attenuated by overexpression of PPARα-tr. Pro-inflammatory genes including IL-1β, CCL2 and TNFα were induced by WY14,643 in mouse and human cells and both PPARα forms attenuated induction. As potential mechanism of PPARα-tr inhibitory action we suggest crosstalk with WNT/β-catenin pathway. Finally

  14. Proliferative capacity of murine hematopoietic stem cells

    International Nuclear Information System (INIS)

    Hellman, S.; Botnick, L.E.; Hannon, E.C.; Vigneulle, R.M.

    1978-01-01

    The present study demonstrates a decrease in self-renewal capacity with serial transfer of murine hematopoietic stem cells. Production of differentiated cell progeny is maintained longer than stem cell self-renewal. In normal animals the capacity for self-renewal is not decreased with increasing donor age. The stem cell compartment in normal animals, both young and old, appears to be proliferatively quiescent. After apparent recovery from the alkylating agent busulfan, the probability of stem cell self-renewal is decreased, there is a permanent defect in the capacity of the bone marrow for serial transplantation, and the stem cells are proliferatively active. These findings support a model of the hematopoietic stem cell compartment as a continuum of cells with decreasing capacities for self-renewal, increasing likelihood for differentiation, and increasing proliferative activity. Cells progress in the continuum in one direction and such progression is not reversible

  15. Reconstitution of active telomerase in primary human foreskin fibroblasts : effects on proliferative characteristics and response to ionizing radiation

    NARCIS (Netherlands)

    Kampinga, H.H.; Waarde-Verhagen, M.A.W.H. van; Assen-Bolt, A.J. van; Rodemann, H.P.; Prowse, K.R.; Linskens, M.H.K.

    2004-01-01

    Purpose: Telomere shortening has been proposed to trigger senescence, and since most primary cells do not express active telomerase, reactivation of telomerase activity was proposed as a safe and non-transforming way of immortalizing cells. However, to study radiation responses, it is as yet unclear

  16. Wound healing morbidity in STS patients treated with preoperative radiotherapy in relation to in vitro skin fibroblast radiosensitivity, proliferative capacity and TGF-β activity

    International Nuclear Information System (INIS)

    Akudugu, John M.; Bell, Robert S.; Catton, Charles; Davis, Aileen M.; Griffin, Anthony M.; O'Sullivan, Brian; Waldron, John N.; Ferguson, Peter C.; Wunder, Jay S.; Hill, Richard P.

    2006-01-01

    Background and purpose: In a recent study, we demonstrated that the ability of dermal fibroblasts, obtained from soft tissue sarcoma (STS) patients, to undergo initial division in vitro following radiation exposure correlated with the development of wound healing morbidity in the patients following their treatment with preoperative radiotherapy. Transforming growth factor beta (TGF-β) is thought to play an important role in fibroblast proliferation and radiosensitivity both of which may impact on wound healing. Thus, in this study we examined the interrelationship between TGF-β activity, radiosensitivity and proliferation of cultured fibroblasts and the wound healing response of STS patients after preoperative radiotherapy to provide a validation cohort for our previous study and to investigate mechanisms. Patients and methods: Skin fibroblasts were established from skin biopsies of 46 STS patients. The treatment group consisted of 28 patients who received preoperative radiotherapy. Eighteen patients constituted a control group who were either irradiated postoperatively or did not receive radiation treatment. Fibroblast cultures were subjected to the colony forming and cytokinesis-blocked binucleation assays (low dose rate: ∼0.02 Gy/min) and TGF-β assays (high dose-rate: ∼1.06 Gy/min) following γ-irradiation. Fibroblast radiosensitivity and initial proliferative ability were represented by the surviving fraction at 2.4 Gy (SF 2.4 ) and binucleation index (BNI), respectively. Active and total TGF-β levels in fibroblast cultures were determined using a biological assay. Wound healing complication (WHC), defined as the requirement for further surgery or prolonged deep wound packing, was the clinical endpoint examined. Results: Of the 28 patients treated with preoperative radiotherapy, 8 (29%) had wound healing difficulties. Fibroblasts from patients who developed WHC showed a trend to retain a significantly higher initial proliferative ability after

  17. Inhibition of H3K27me3 Histone Demethylase Activity Prevents the Proliferative Regeneration of Zebrafish Lateral Line Neuromasts

    Science.gov (United States)

    Bao, Beier; He, Yingzi; Tang, Dongmei; Li, Wenyan; Li, Huawei

    2017-01-01

    The H3K27 demethylases are involved in a variety of biological processes, including cell differentiation, proliferation, and cell death by regulating transcriptional activity. However, the function of H3K27 demethylation in the field of hearing research is poorly understood. Here, we investigated the role of H3K27me3 histone demethylase activity in hair cell regeneration using an in vivo animal model. Our data showed that pharmacologic inhibition of H3K27 demethylase activity with the specific small-molecule inhibitor GSK-J4 decreased the number of regenerated hair cells in response to neomycin damage. Furthermore, inhibition of H3K27me3 histone demethylase activity dramatically suppressed cell proliferation and activated caspase-3 levels in the regenerating neuromasts of the zebrafish lateral line. GSK-J4 administration also increased the expression of p21 and p27 in neuromast cells and inhibited the ERK signaling pathway. Collectively, our findings indicate that H3K27me3 demethylation is a key epigenetic regulator in the process of hair cell regeneration in zebrafish and suggest that H3K27me3 histone demethylase activity might be a novel therapeutic target for the treatment of hearing loss. PMID:28348517

  18. The effect of beta-hydroxy-beta-methylbutyrate (HMB) on the proliferative response of blood lymphocytes and the phagocytic activity of blood monocytes and granulocytes in calves.

    Science.gov (United States)

    Wójcik, R; Małaczewska, J; Siwicki, A K; Miciński, J; Zwierzchowski, G

    2013-01-01

    The objective of this study was to evaluate the effect of HMB on selected indicators of immunity in calves. The experiment was performed on 14 calves aged 30 +/- 2 days, divided into two equal groups of control (group I) and experimental (group II) animals. The feed administered to experimental group calves was supplemented with HMB at 40 mg/kg BW, whereas control calves were administered standard farm-made feed without supplementation. Blood was sampled from the jugular vein immediately before the experiment (day 0) and on experimental days 15, 30 and 60 to determine the following parameters of immunity: proliferative response of LPS- and ConA-stimulated lymphocytes (MTT), respiratory burst activity (RBA) and potential killing activity (PKA) of phagocytes. The results revealed a significant increase in RBA and MTT values in calves administered HMB in comparison with the control group throughout the experiment. In the group of animals receiving HMB, an increase in PKA values was noted only on day 30.

  19. Anti-Proliferative Activity of Meroditerpenoids Isolated from the Brown Alga Stypopodium flabelliforme against Several Cancer Cell Lines

    Directory of Open Access Journals (Sweden)

    Patricia Valentao

    2011-05-01

    Full Text Available The sea constitutes one of the most promising sources of novel compounds with potential application in human therapeutics. In particular, algae have proved to be an interesting source of new bioactive compounds. In this work, six meroditerpenoids (epitaondiol, epitaondiol diacetate, epitaondiol monoacetate, stypotriol triacetate, 14-ketostypodiol diacetate and stypodiol isolated from the brown alga Stypopodium flabelliforme were tested for their cell proliferation inhibitory activity in five cell lines. Cell lines tested included human colon adenocarcinoma (Caco-2, human neuroblastoma (SH-SY5Y, rat basophilic leukemia (RBL-2H3, murine macrophages (RAW.267 and Chinese hamster fibroblasts (V79. Antimicrobial activity of the compounds was also evaluated against Staphylococcus aureus, Salmonella typhimurium, Proteus mirabilis, Bacillus cereus, Enterococcus faecalis and Micrococcus luteus. Overall, the compounds showed good activity against all cell lines, with SH-SY5Y and RAW.267 being the most susceptible. Antimicrobial capacity was observed for epitaondiol monoacetate, stypotriol triacetate and stypodiol, with the first being the most active. The results suggest that these molecules deserve further studies in order to evaluate their potential as therapeutic agents.

  20. The KDM5 family is required for activation of pro-proliferative cell cycle genes during adipocyte differentiation

    DEFF Research Database (Denmark)

    Brier, Ann-Sofie B; Loft, Anne; Madsen, Jesper G S

    2017-01-01

    The KDM5 family of histone demethylases removes the H3K4 tri-methylation (H3K4me3) mark frequently found at promoter regions of actively transcribed genes and is therefore generally considered to contribute to corepression. In this study, we show that knockdown (KD) of all expressed members...... of the KDM5 family in white and brown preadipocytes leads to deregulated gene expression and blocks differentiation to mature adipocytes. KDM5 KD leads to a considerable increase in H3K4me3 at promoter regions; however, these changes in H3K4me3 have a limited effect on gene expression per se. By contrast......, genome-wide analyses demonstrate that KDM5A is strongly enriched at KDM5-activated promoters, which generally have high levels of H3K4me3 and are associated with highly expressed genes. We show that KDM5-activated genes include a large set of cell cycle regulators and that the KDM5s are necessary...

  1. Endothelin-1 activation of ETB receptors leads to a reduced cellular proliferative rate and an increased cellular footprint

    International Nuclear Information System (INIS)

    Wilson, Jamie L.; Taylor, Linda; Polgar, Peter

    2012-01-01

    Endothelin-1 (ET-1) is a vasoactive peptide which signals through two G-protein coupled receptors, endothelin receptor A (ETA) and B (ETB). We determined that ET-1 activation of its ETB receptor in stably cDNA transfected CHO cells leads to a 55% reduction in cell number by end-point cell counting and a 35% decrease in cell growth by a real-time cell-substrate impedance-based assay after 24 h of cell growth. When CHO ETB cells were synchronized in the late G1 cell cycle phase, ET-1 delayed their S phase progression compared to control by 30% as determined by [ 3 H]-thymidine incorporation. On the other hand, no such delay was observed during late G2/M to G1 transit when cells were treated with ET-1 after release from mitotic arrest. Using the cell-substrate impedance-based assay, we observed that ET-1 induces opposing morphological changes in CHO ETA and CHO ETB cells with ETB causing an increase in the cell footprint and ETA a decrease. Likewise, in pulmonary artery smooth muscle cells, which express both ETA and ETB receptors, ET-1 induces an ETA-dependent contraction and an ETB dependent dilation. These results are shedding light on a possible beneficial role for ETB in diseases involving ET-1 dysfunction such as pulmonary hypertension. -- Highlights: ► ET- hinders cell proliferation in CHO cells transfected with ETB. ► ET-1 also decreases the rate of DNA synthesis in CHO ETB cells. ► JNK and PI3K appear to be involved in this reduction of DNA synthesis. ► ETB activation in CHO ETB cells and hSMCs leads to dilatory morphological changes. ► In CHO ETA and hSMCs, ETA activation leads to constrictive morphological changes.

  2. Endothelin-1 activation of ETB receptors leads to a reduced cellular proliferative rate and an increased cellular footprint

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Jamie L.; Taylor, Linda; Polgar, Peter, E-mail: peterp@bu.edu

    2012-06-10

    Endothelin-1 (ET-1) is a vasoactive peptide which signals through two G-protein coupled receptors, endothelin receptor A (ETA) and B (ETB). We determined that ET-1 activation of its ETB receptor in stably cDNA transfected CHO cells leads to a 55% reduction in cell number by end-point cell counting and a 35% decrease in cell growth by a real-time cell-substrate impedance-based assay after 24 h of cell growth. When CHO ETB cells were synchronized in the late G1 cell cycle phase, ET-1 delayed their S phase progression compared to control by 30% as determined by [{sup 3}H]-thymidine incorporation. On the other hand, no such delay was observed during late G2/M to G1 transit when cells were treated with ET-1 after release from mitotic arrest. Using the cell-substrate impedance-based assay, we observed that ET-1 induces opposing morphological changes in CHO ETA and CHO ETB cells with ETB causing an increase in the cell footprint and ETA a decrease. Likewise, in pulmonary artery smooth muscle cells, which express both ETA and ETB receptors, ET-1 induces an ETA-dependent contraction and an ETB dependent dilation. These results are shedding light on a possible beneficial role for ETB in diseases involving ET-1 dysfunction such as pulmonary hypertension. -- Highlights: Black-Right-Pointing-Pointer ET- hinders cell proliferation in CHO cells transfected with ETB. Black-Right-Pointing-Pointer ET-1 also decreases the rate of DNA synthesis in CHO ETB cells. Black-Right-Pointing-Pointer JNK and PI3K appear to be involved in this reduction of DNA synthesis. Black-Right-Pointing-Pointer ETB activation in CHO ETB cells and hSMCs leads to dilatory morphological changes. Black-Right-Pointing-Pointer In CHO ETA and hSMCs, ETA activation leads to constrictive morphological changes.

  3. Transcriptional Regulation of Δ6-Desaturase by Peroxisome Proliferative-Activated Receptor δ Agonist in Human Pancreatic Cancer Cells: Role of MEK/ERK1/2 Pathway

    Directory of Open Access Journals (Sweden)

    Maryam Darabi

    2013-01-01

    Full Text Available The Δ6-desaturase (Δ6D, also known as fatty acid desaturase 2, is a regulatory enzyme in de novo fatty acid synthesis, which has been linked to obesity and diabetes. The aim of the present study was to investigate the effect of peroxisome proliferative-activated receptor δ (PPARδ agonist and MEK/ERK1/2-dependent pathway on the expression of Δ6D in human pancreatic carcinoma cell line PANC-1. PANC-1 cells cultured in RPMI-1640 were exposed to the commonly used ERK1/2 pathway inhibitor PD98059 and PPARδ agonist GW0742. Changes in mRNA and protein expression of Δ6D were then determined using real-time RT-PCR and Western blot, respectively. The expression of Δ6D (P40%, P25%, P<0.05 pretreatment. PPARδ and MEK/ERK1/2 signaling pathways affect differentially the expression of Δ6D in pancreatic cancer cells. Furthermore, there may be an inhibitory crosstalk between these two regulatory pathways on the mRNA expression of Δ6D and subsequently on Δ6D protein expression.

  4. Histogram Analysis of Diffusion Weighted Imaging at 3T is Useful for Prediction of Lymphatic Metastatic Spread, Proliferative Activity, and Cellularity in Thyroid Cancer.

    Science.gov (United States)

    Schob, Stefan; Meyer, Hans Jonas; Dieckow, Julia; Pervinder, Bhogal; Pazaitis, Nikolaos; Höhn, Anne Kathrin; Garnov, Nikita; Horvath-Rizea, Diana; Hoffmann, Karl-Titus; Surov, Alexey

    2017-04-12

    Pre-surgical diffusion weighted imaging (DWI) is increasingly important in the context of thyroid cancer for identification of the optimal treatment strategy. It has exemplarily been shown that DWI at 3T can distinguish undifferentiated from well-differentiated thyroid carcinoma, which has decisive implications for the magnitude of surgery. This study used DWI histogram analysis of whole tumor apparent diffusion coefficient (ADC) maps. The primary aim was to discriminate thyroid carcinomas which had already gained the capacity to metastasize lymphatically from those not yet being able to spread via the lymphatic system. The secondary aim was to reflect prognostically important tumor-biological features like cellularity and proliferative activity with ADC histogram analysis. Fifteen patients with follicular-cell derived thyroid cancer were enrolled. Lymph node status, extent of infiltration of surrounding tissue, and Ki-67 and p53 expression were assessed in these patients. DWI was obtained in a 3T system using b values of 0, 400, and 800 s/mm². Whole tumor ADC volumes were analyzed using a histogram-based approach. Several ADC parameters showed significant correlations with immunohistopathological parameters. Most importantly, ADC histogram skewness and ADC histogram kurtosis were able to differentiate between nodal negative and nodal positive thyroid carcinoma. histogram analysis of whole ADC tumor volumes has the potential to provide valuable information on tumor biology in thyroid carcinoma. However, further studies are warranted.

  5. Studies quantifying modulatory effects of inhaled NO2 and SO2 on tracheal mucus secretion, proliferative activity of airway epithelium and architecture of lung parenchyma

    International Nuclear Information System (INIS)

    Wagner, U.; Barth, P.J.; Bredenbroeker, D.; Haase, H.; Locher, A.; Janssen, P.; Yu, F.; Wichert, P. von

    1995-10-01

    The following studies were designed to quantify changes in tracheal mucus secretion and epithelial proliferation of peripheral airways induced by inhaled NO 2 and SO 2 . Groups of male Sprague-Dawley rats were exposed alternatively to 1, 5, 10 and 20 ppm NO 2 and SO 2 the exposure-time being 3 or 25 days (d) respectively. Studies of tracheal mucus secretion radiolabelling mucins with 35 S clearly demonstrated a concentration dependant modulation of mucus secretion. We were able to demonstrate for the first time a significant increase of mucus secretion due to submucosal application of the peptide hormone GLP-1(7-36)amide. We were able to demonstrate amylin to be a potent secretagogue, dose-dependently stimulating mucus secretion. Our morphologic data reveal the effects caused by concentrations between 4-5 ppm NO 2 to be so small, that they are hardly detectable at light microscopic level. The assessment of proliferative activity, however, clearly demonstrates an increased proliferation due to even lower concentrations indicating, that even 1 ppm is able to cause epithelial impairment with consecutive regeneration. Double-labelling techniques of proliferation markers and the 10 kD Clara cell specific antigen reveal the Clara cell to be the only source for epithelial regeneration in peripheral airways under the reported experimental conditions of this study. (orig.) [de

  6. Resveratrol prevents oxidative stress-induced senescence and proliferative dysfunction by activating the AMPK-FOXO3 cascade in cultured primary human keratinocytes.

    Directory of Open Access Journals (Sweden)

    Yasuo Ido

    Full Text Available The aging process is perceived as resulting from a combination of intrinsic factors such as changes in intracellular signaling and extrinsic factors, most notably environmental stressors. In skin, the relationship between intrinsic changes and keratinocyte function is not clearly understood. Previously, we found that increasing the activity of AMP-activated protein kinase (AMPK suppressed senescence in hydrogen peroxide (H2O2-treated human primary keratinocytes, a model of oxidative stress-induced cellular aging. Using this model in the present study, we observed that resveratrol, an agent that increases the activities of both AMPK and sirtuins, ameliorated two age-associated phenotypes: cellular senescence and proliferative dysfunction. In addition, we found that treatment of keratinocytes with Ex527, a specific inhibitor of sirtuin 1 (SIRT1, attenuated the ability of resveratrol to suppress senescence. In keeping with the latter observation, we noted that compared to non-senescent keratinocytes, senescent cells lacked SIRT1. In addition to these effects on H2O2-induced senescence, resveratrol also prevented the H2O2-induced decrease in proliferation (as indicated by 3H-thymidine incorporation in the presence of insulin. This effect was abrogated by inhibition of AMPK but not SIRT1. Compared to endothelium, we found that human keratinocytes expressed relatively high levels of Forkhead box O3 (FOXO3, a downstream target of both AMPK and SIRT1. Treatment of keratinocytes with resveratrol transactivated FOXO3 and increased the expression of its target genes including catalase. Resveratrol's effects on both senescence and proliferation disappeared when FOXO3 was knocked down. Finally, we performed an exploratory study which showed that skin from humans over 50 years old had lower AMPK activity than skin from individuals under age 20. Collectively, these findings suggest that the effects of resveratrol on keratinocyte senescence and proliferation

  7. Literary Hermeneutic - A Large Vision upon the Text

    Directory of Open Access Journals (Sweden)

    Elena Vorotneac

    2011-12-01

    Full Text Available This article represents the book “Literary Hermeneutic” by Victoria Fonari, Ph.D., State University of Moldova. Hermeneutic, as a researching object, includes literary, critical, theological, juridical, linguistic, psychological, verbal and sociological knowledge. Literary Hermeneutic is one of the most favored disciplines. It is venerated both in Homeric exegesis from antiquity and in the improvement of the methodology interpretation of the canonical works, in which a vain moment is texts’ deciphering – the monuments and authors’ comment from times immemorial, thus re-establishing a part of human values. The re-establishing of the connections between the values of the past and their understanding from the present prospect is due to literary interpretation. The demands of the paradigm of the literary and artistic interpretation, constitutes a basic element which is important both for the writing of academic researches and for the literary values of understanding. It directs the student to scientific works and facilitated the professional activity of teachers, journalists, jurists and translators.

  8. Literary practice and the island

    Directory of Open Access Journals (Sweden)

    Aline Rocha

    2016-11-01

    Full Text Available http://dx.doi.org/10.5007/1984-784X.2016v16n25p146 The anthology Sobre poesia: outras vozes, published by 7Letras and edited by the literary critics Celia Pedrosa and Ida Alves, brings a sample of the poetic production scenario and of the criticism developed in the contemporaneity. Gathering nine young writers of the today Brazilian, Portuguese, Argentinian and Mexican literary scenes, the heterogeneity of the written and of the theoretical approaches has an experimental character. The selection shows, in short, a stimulus to new creative impulses.

  9. Paracrine stimulation of P2X7 receptor by ATP activates a proliferative pathway in ovarian carcinoma cells.

    Science.gov (United States)

    Vázquez-Cuevas, Francisco G; Martínez-Ramírez, Angélica S; Robles-Martínez, Leticia; Garay, Edith; García-Carrancá, Alejandro; Pérez-Montiel, Delia; Castañeda-García, Carolina; Arellano, Rogelio O

    2014-11-01

    P2X7 is a purinergic receptor-channel; its activation by ATP elicits a broad set of cellular actions, from apoptosis to signals for survival. Here, P2X7 expression and function was studied in human ovarian carcinoma (OCA) cells, and biopsies from non-cancerous and cancer patients were analyzed by immunohistochemistry. Ovarian surface epithelium in healthy tissue expressed P2X7 at a high level that was maintained throughout the cancer. The cell lines SKOV-3 and CAOV-3 were used to investigate P2X7 functions in OCA. In SKOV-3 cells, selective stimulation of P2X7 by 2'(3')-O-(4-benzoylbenzoyl) adenosine-5'-triphosphate (BzATP) induced a dose-dependent increase of intracellular Ca(2+) concentration ([Ca(2+)](i)) but not cell death. Instead, BzATP increased the levels of phosphorylated ERK and AKT (pERK and pAKT), with an EC(50) of 44 ± 2 and 1.27 ± 0.5 μM, respectively; 10 μM BzATP evoked a maximum effect within 15 min that lasted for 120 min. Interestingly, basal levels of pERK and pAKT were decreased in the presence of apyrase in the medium, strongly suggesting an endogenous, ATP-mediated phenomenon. Accordingly: (i) mechanically stimulated cells generated a [Ca(2+)](i) increase that was abolished by apyrase; (ii) apyrase induced a decrease in culture viability, as measured by the MTS assay for mitochondrial activity; and (iii) incubation with 10 μM AZ10606120, a specific P2X7 antagonist and transfection with the dominant negative P2X7 mutant E496A, both reduced cell viability to 70.1 ± 8.9% and to 76.5 ± 5%, respectively, of control cultures. These observations suggested that P2X7 activity was auto-induced through ATP efflux; this increased pERK and pAKT levels that generated a positive feedback on cell viability. © 2014 Wiley Periodicals, Inc.

  10. Impact of maternal diabetes type 1 on proliferative potential, differentiation and apoptotic activity in villous capillaries of term placenta.

    Science.gov (United States)

    Jirkovská, Marie; Kučera, Tomáš; Dvořáková, Veronika; Jadrníček, Martin; Moravcová, Milena; Žižka, Zdeněk; Krejčí, Vratislav

    2016-04-01

    Maternal diabetes mellitus changes morphology and impairs function of placental capillaries. Here, quantitative parameters characterizing cell proliferation using detection of Ki67, differentiation reflected by nestin expression and apoptosis in placental capillary bed with active caspase 3 as a marker were compared in normal term placentas and placentas from pregnancies complicated by Type 1 maternal diabetes mellitus. Specimens of sixteen diabetic placentas and eight control placentas were collected by systematic uniform random sampling. Immunohistochemical detections of Ki67, nestin, and active caspase 3 were performed in histological sections of five haphazardly chosen blocks per placenta. Twenty fields of view per section, i.e. one hundred fields of view per placenta, were used for analysis of proliferation as well as of apoptosis, and in approximately 70 capillary cross-sections per placenta the nestin-positive segments of their circumference were measured. The percentage of Ki67-positive cells counted in the capillary wall was significantly lower in diabetic group. The counts of Ki67-labelled nuclei per villous area unit were significantly lower in cytotrophoblast and capillary wall of terminal villi in diabetic placenta. The proportion of nestin-labeled segments of capillary circumference was significantly higher in placentas of diabetic group. No differences in the numbers of apoptotic cells were found between studied groups. The results show that the term placenta in Type 1 diabetes has lower potential to enlarge the surface area of structures involved in maternofetal transport, and that the villous capillary bed displays delayed differentiation. Those factors may participate in decreased ability of diabetic placenta to comply with fetal requirements in the final stage of pregnancy. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. SGR J1550-5418 BURSTS DETECTED WITH THE FERMI GAMMA-RAY BURST MONITOR DURING ITS MOST PROLIFIC ACTIVITY

    Energy Technology Data Exchange (ETDEWEB)

    Van der Horst, A. J.; Finger, M. H. [Universities Space Research Association, NSSTC, Huntsville, AL 35805 (United States); Kouveliotou, C. [Space Science Office, VP62, NASA/Marshall Space Flight Center, Huntsville, AL 35812 (United States); Gorgone, N. M. [Connecticut College, New London, CT 06320 (United States); Kaneko, Y.; Goegues, E.; Lin, L. [Sabanc Latin-Small-Letter-Dotless-I University, Orhanl Latin-Small-Letter-Dotless-I -Tuzla, Istanbul 34956 (Turkey); Baring, M. G. [Department of Physics and Astronomy, Rice University, MS-108, P.O. Box 1892, Houston, TX 77251 (United States); Guiriec, S.; Bhat, P. N.; Chaplin, V. L.; Goldstein, A. [University of Alabama, Huntsville, CSPAR, Huntsville, AL 35805 (United States); Granot, J. [Racah Institute of Physics, Hebrew University, Jerusalem 91904 (Israel); Watts, A. L. [Astronomical Institute ' Anton Pannekoek' , University of Amsterdam, Postbus 94249, 1090 GE Amsterdam (Netherlands); Bissaldi, E.; Gruber, D. [Max Planck Institute for Extraterrestrial Physics, Giessenbachstrasse, Postfach 1312, 85748 Garching (Germany); Gehrels, N.; Harding, A. K. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Gibby, M. H.; Giles, M. M., E-mail: A.J.VanDerHorst@uva.nl [Jacobs Technology, Inc., Huntsville, AL (United States); and others

    2012-04-20

    We have performed detailed temporal and time-integrated spectral analysis of 286 bursts from SGR J1550-5418 detected with the Fermi Gamma-ray Burst Monitor (GBM) in 2009 January, resulting in the largest uniform sample of temporal and spectral properties of SGR J1550-5418 bursts. We have used the combination of broadband and high time-resolution data provided with GBM to perform statistical studies for the source properties. We determine the durations, emission times, duty cycles, and rise times for all bursts, and find that they are typical of SGR bursts. We explore various models in our spectral analysis, and conclude that the spectra of SGR J1550-5418 bursts in the 8-200 keV band are equally well described by optically thin thermal bremsstrahlung (OTTB), a power law (PL) with an exponential cutoff (Comptonized model), and two blackbody (BB) functions (BB+BB). In the spectral fits with the Comptonized model, we find a mean PL index of -0.92, close to the OTTB index of -1. We show that there is an anti-correlation between the Comptonized E{sub peak} and the burst fluence and average flux. For the BB+BB fits, we find that the fluences and emission areas of the two BB functions are correlated. The low-temperature BB has an emission area comparable to the neutron star surface area, independent of the temperature, while the high-temperature BB has a much smaller area and shows an anti-correlation between emission area and temperature. We compare the properties of these bursts with bursts observed from other SGR sources during extreme activations, and discuss the implications of our results in the context of magnetar burst models.

  12. SGR J1550-5418 Bursts Detected with the Fermi Gamma-Ray Burst Monitor during Its Most Prolific Activity

    Science.gov (United States)

    vanderHorst, A. J.; Kouveliotou, C.; Gorgone, N. M.; Kaneko, Y.; Baring, M. G.; Guiriec, S.; Gogus, E,; Granot, J.; Watts, A. L.; Lin, L.; hide

    2012-01-01

    We have performed detailed temporal and time-integrated spectral analysis of 286 bursts from SGR J1550-5418 detected with the Fermi Gamma-ray Burst Monitor (GBM) in 2009 January, resulting in the largest uniform sample of temporal and spectral properties of SGR J1550-5418 bursts. We have used the combination of broadband and high time-resolution data provided with GBM to perform statistical studies for the source properties.We determine the durations, emission times, duty cycles, and rise times for all bursts, and find that they are typical of SGR bursts. We explore various models in our spectral analysis, and conclude that the spectra of SGR J15505418 bursts in the 8-200 keV band are equally well described by optically thin thermal bremsstrahlung (OTTB), a power law (PL) with an exponential cutoff (Comptonized model), and two blackbody (BB) functions (BB+BB). In the spectral fits with the Comptonized model, we find a mean PL index of -0.92, close to the OTTB index of -1. We show that there is an anti-correlation between the Comptonized E(sub peak) and the burst fluence and average flux. For the BB+BBfits, we find that the fluences and emission areas of the two BB functions are correlated. The low-temperature BB has an emission area comparable to the neutron star surface area, independent of the temperature, while the high temperature BB has a much smaller area and shows an anti-correlation between emission area and temperature.We compare the properties of these bursts with bursts observed from other SGR sources during extreme activations, and discuss the implications of our results in the context of magnetar burst models.

  13. The Viability of Literary Texts.

    Science.gov (United States)

    Gambone, Kenneth Felix

    This study explored whether or not there was an increase in understanding from one literary genre to another, whether or not this growth was apparent from one grade level to another, and whether the growth followed Northrop Frye's suggestion of order: romance, comedy, tragedy, and satire. The high school subjects were asked to read "Merchant of…

  14. Quantitative criticism of literary relationships.

    Science.gov (United States)

    Dexter, Joseph P; Katz, Theodore; Tripuraneni, Nilesh; Dasgupta, Tathagata; Kannan, Ajay; Brofos, James A; Bonilla Lopez, Jorge A; Schroeder, Lea A; Casarez, Adriana; Rabinovich, Maxim; Haimson Lushkov, Ayelet; Chaudhuri, Pramit

    2017-04-18

    Authors often convey meaning by referring to or imitating prior works of literature, a process that creates complex networks of literary relationships ("intertextuality") and contributes to cultural evolution. In this paper, we use techniques from stylometry and machine learning to address subjective literary critical questions about Latin literature, a corpus marked by an extraordinary concentration of intertextuality. Our work, which we term "quantitative criticism," focuses on case studies involving two influential Roman authors, the playwright Seneca and the historian Livy. We find that four plays related to but distinct from Seneca's main writings are differentiated from the rest of the corpus by subtle but important stylistic features. We offer literary interpretations of the significance of these anomalies, providing quantitative data in support of hypotheses about the use of unusual formal features and the interplay between sound and meaning. The second part of the paper describes a machine-learning approach to the identification and analysis of citational material that Livy loosely appropriated from earlier sources. We extend our approach to map the stylistic topography of Latin prose, identifying the writings of Caesar and his near-contemporary Livy as an inflection point in the development of Latin prose style. In total, our results reflect the integration of computational and humanistic methods to investigate a diverse range of literary questions.

  15. “Journeys of the mind” in the Russian Cultural Society of the 1760-s. Educational and Publishing activity of Kheraskov Literary Circle

    Directory of Open Access Journals (Sweden)

    Natalia D. Bludilina

    2016-09-01

    Full Text Available This article examines one of the pages of the history of Russian Freemasonry as a philosophical and ideological trend within the circles of reflective minds of the Russian society and its influence on the literary process; in particular, it explores a connection of Freemasonry rationalist philosophy with the “journeys of the mind” in the works of M.M.Kheraskov and his Moscow literary circle (A.P.Sumarokov, A. A.Nartov, A. A.Rzhevsky, Alex and Simon Naryshkin, D. Anichkov, J. I. Bulgakov, V. I.Maikov, and I.F. Bogdanovich that to a certain extent reflected complex processes of the development of spiritual culture in the eighteenth century Russia. For the members of Moscow literary circle, a journal was not only the most efficient way to establish and maintain contacts with the readers but also the means of enlightening contemporaries introducing them to literature. These literati, for the first time in history, developed a group with its own philosophical, political, and literary position: they claimed that enlightened mind creates and perfects a soul that is open to kindness and love and that moral life is based on the awareness of the moral imperative. The essay analyzes didactic essays by the above mentioned authors and their translations (from Montaigne, Fontenelle, Voltaire, Dodsli, and Gellert — a circle of spiritual reading they promoted in chronological order of their publication in the magazines issued in the 1760 ‘s: “Useful Jollification,” “Free Hours,” “Monthly Essays Serving to Instruct and Entertain,” “Idle Time,” and “Hardworking Bee.” As the analysis reveals, they understood enlightenment mainly as self-knowledge and self-improvement of a single individual; intellectual connection was reduced to the narrow circle of single-minded and educated persons. To understand the “laws of the mind” and to build a life of body and soul on their basis was the goal that Russian Freemason authors pursued as they

  16. Immune gene expression profiling of Proliferative Kidney Disease in rainbow trout Oncorhynchus mykiss reveals a dominance of anti-inflammatory, antibody and T helper cell-like activities.

    Science.gov (United States)

    Gorgoglione, Bartolomeo; Wang, Tiehui; Secombes, Christopher J; Holland, Jason W

    2013-07-16

    The myxozoan Tetracapsuloides bryosalmonae is the causative agent of Proliferative Kidney Disease (PKD) targeting primarily the kidney of infected fish where it causes a chronic lymphoid immunopathology. Although known to be associated with suppression of some cellular aspects of innate immunity and a prominent lymphocytic hyperplasia, there remains a considerable knowledge gap in our understanding of the underlying immune mechanisms driving PKD pathogenesis. To provide further insights, the expression profiles of a panel of innate/inflammatory and adaptive immune molecules were examined in rainbow trout Oncorhynchus mykiss following a natural exposure to the parasite. Relative to controls, fish with early to advanced stages of kidney pathology exhibited up-regulation of the inflammatory cytokines interleukin (IL)-6 and IL-11, although remaining refractory towards genes indicative of macrophage activity. Antimicrobial peptides (AMPs) and anti-inflammatory markers, including cathelicidin (CATH) and IL-10 were markedly up-regulated during clinical disease. Up-regulation of adaptive immune molecules, including cell markers and antibody genes reflect the lymphocytic dominance of this disease and the likely importance of lymphocyte subsets in PKD pathogenesis. Up-regulation of T helper (TH) cell-like response genes and transcription factors implies that T. bryosalmonae may elicit a complex interplay between TH cell subsets. This work, for the first time in the study of fish-myxozoan interactions, suggests that PKD pathogenesis is shaped by an anti-inflammatory phenotype, a profound B cell/antibody response and dysregulated TH cell-like activities. A better understanding of the functional roles of fish immune cells and molecules in PKD pathogenesis may facilitate future development of control measures against this disease.

  17. Immune gene expression profiling of Proliferative Kidney Disease in rainbow trout Oncorhynchus mykiss reveals a dominance of anti-inflammatory, antibody and T helper cell-like activities

    Science.gov (United States)

    2013-01-01

    The myxozoan Tetracapsuloides bryosalmonae is the causative agent of Proliferative Kidney Disease (PKD) targeting primarily the kidney of infected fish where it causes a chronic lymphoid immunopathology. Although known to be associated with suppression of some cellular aspects of innate immunity and a prominent lymphocytic hyperplasia, there remains a considerable knowledge gap in our understanding of the underlying immune mechanisms driving PKD pathogenesis. To provide further insights, the expression profiles of a panel of innate / inflammatory and adaptive immune molecules were examined in rainbow trout Oncorhynchus mykiss following a natural exposure to the parasite. Relative to controls, fish with early to advanced stages of kidney pathology exhibited up-regulation of the inflammatory cytokines interleukin (IL)-6 and IL-11, although remaining refractory towards genes indicative of macrophage activity. Antimicrobial peptides (AMPs) and anti-inflammatory markers, including cathelicidin (CATH) and IL-10 were markedly up-regulated during clinical disease. Up-regulation of adaptive immune molecules, including cell markers and antibody genes reflect the lymphocytic dominance of this disease and the likely importance of lymphocyte subsets in PKD pathogenesis. Up-regulation of T helper (TH) cell-like response genes and transcription factors implies that T. bryosalmonae may elicit a complex interplay between TH cell subsets. This work, for the first time in the study of fish-myxozoan interactions, suggests that PKD pathogenesis is shaped by an anti-inflammatory phenotype, a profound B cell / antibody response and dysregulated TH cell-like activities. A better understanding of the functional roles of fish immune cells and molecules in PKD pathogenesis may facilitate future development of control measures against this disease. PMID:23865616

  18. Comparative Study of Green Sub- and Supercritical Processes to Obtain Carnosic Acid and Carnosol-Enriched Rosemary Extracts with in Vitro Anti-Proliferative Activity on Colon Cancer Cells

    Directory of Open Access Journals (Sweden)

    Andrea del Pilar Sánchez-Camargo

    2016-12-01

    Full Text Available In the present work, four green processes have been compared to evaluate their potential to obtain rosemary extracts with in vitro anti-proliferative activity against two colon cancer cell lines (HT-29 and HCT116. The processes, carried out under optimal conditions, were: (1 pressurized liquid extraction (PLE, using an hydroalcoholic mixture as solvent at lab-scale; (2 Single-step supercritical fluid extraction (SFE at pilot scale; (3 Intensified two-step sequential SFE at pilot scale; (4 Integrated PLE plus supercritical antisolvent fractionation (SAF at pilot scale. Although higher extraction yields were achieved by using PLE (38.46% dry weight, this extract provided the lowest anti-proliferative activity with no observed cytotoxic effects at the assayed concentrations. On the other hand, extracts obtained using the PLE + SAF process provided the most active rosemary extracts against both colon cancer cell lines, with LC50 ranging from 11.2 to 12.4 µg/mL and from 21.8 to 31.9 µg/mL for HCT116 and HT-29, respectively. In general, active rosemary extracts were characterized by containing carnosic acid (CA and carnosol (CS at concentrations above 263.7 and 33.9 mg/g extract, respectively. Some distinct compounds have been identified in the SAF extracts (rosmaridiphenol and safficinolide, suggesting their possible role as additional contributors to the observed strong anti-proliferative activity of CA and CS in SAF extracts.

  19. Reader responses to literary depictions of rape

    NARCIS (Netherlands)

    E.M. Koopman (Emy); M. Hilscher (Michelle); G.C. Cupchik (Gerald)

    2012-01-01

    textabstractThis study explored reader responses to different literary depictions of rape. Four literary excerpts were used and divided as aesthetic versus nonaesthetic (style) and allusive versus explicit (detail). The general question was how readers would react to literary fragments depicting

  20. An Introduction to Literary Quaranic Stylistics

    Science.gov (United States)

    Almenoar, Lubna

    2010-01-01

    A stylistic analysis is one approach of analyzing a literary text using literary descriptions. The use of literary texts in the literature classroom has been limited to mostly Western sources. This paper is an attempt to create an awareness of the linguistic features present in the English language translations of the meaning of the Quran. The…

  1. Literary heritage and place building for communities: the case of Allier, France

    Directory of Open Access Journals (Sweden)

    Pierre-Mathieu Le Bel

    2017-03-01

    Full Text Available Literature’s geography takes an active part in the construction of a social and political space. In a postmodern context of increasing tourist offer and demand, literary tourism is often seen as a niche; an originality factor and a guaranty of authenticity by local development actors and visitors. The present article, consequently, is interested in this dialectic between places and literary heritage. This paper focuses on a participatory action research on citizen associations that promote literary heritage of the County of Allier, France. We look at how local associations build on literary heritage to produce places and representations of those places are aimed at tourist consumption.

  2. A Literary Feast.

    Science.gov (United States)

    Mayo, Jeanne Pilgrim

    2000-01-01

    Suggests activities for library media specialists or teachers that use food to encourage students to interact with literature. Includes researching recipes or food items that appear in the book, incorporating Internet searching skills if desired; planning meals, either real or imaginary; edible art projects, including fortune cookies; and creating…

  3. Adolescents, curriculum, and literary competence

    Directory of Open Access Journals (Sweden)

    Guadalupe López Bonilla

    2006-11-01

    Full Text Available In this paper we look at access to literary texts, and analyze literacy practices in a specific context and domain: high school literature classes. We start out from a sociocultural perspective for our study of literacy events and practices. In particular, we have begun our research supported by the work of Mary Hamilton and the New Literacy Studies to identify events and their components, in order to infer the practices that give meaning to the events observed. The study was conducted in a state high school (COBACH, and in a federal high school offering two different programs: the General Diploma (GD, similar to that of the COBACH, and the International Baccalaureate Diploma (IB. The results allow us to surmise what type of reader and level of literary competency is offered by each scholastic culture.

  4. Post-Digital Literary Studies

    Directory of Open Access Journals (Sweden)

    Florian Cramer

    2016-03-01

    Full Text Available Digital humanities and digital literary studies face much the same challenges as contemporary media art: what will become of them once their media are no longer “new”, and the limitations of processing art as data have become more clearly and widely understood? This paper revisits information aesthetics and computer poetics from the 1960s and 1970s, casting them as precursors of today’s digital humanities, with many of the same issues, achievements and failures, and with their own hype cycles of boom and bust. Conversely, “post-digital” and “Post-Internet” trends in music, graphic design and visual arts may anticipate possible futures of digital humanities and literary studies after the hype has passed.

  5. Literary Library for Physicians (II

    Directory of Open Access Journals (Sweden)

    Fernando A. NAVARRO

    2015-10-01

    Full Text Available The adequate practice of medicine is a difficult job if some intimate and deep feelings of patients, such pain, loneliness, depression and helplessness facing an incurable disease or the fear of dying, are not fully understood. A good way to gain a satisfactory understanding of such feelings might be the reading of the great literary works of all times. In this “Medical library for physicians” an essential list of seventy literary works from the Modern to the Contemporary periods has been collected. Their plot is about the disease, the madness, the hospital, the professionalism and the historical and social images of the physicians. In the second part of the article, a brief review of the last thirty?five books is carried out. It considers from Sinuhe egyptiläinen (1945 by Mika Waltari to Nemesis (1943 by Philip Roth.

  6. Linguistic Levels of Translation: A Generic Exploration of Translation Difficulties in Literary Textual Corpus

    Directory of Open Access Journals (Sweden)

    Magda Madkour

    2016-11-01

    Full Text Available This case study research was based on a generic exploration of the translation problems that graduate students face in literary translation. Literary translation is fundamental to translation programs at higher education due to the upsurge that has occurred in publishing classical and modern literary works from various cultures. However, literary texts have special characteristics that make the process of transferring them from one language into another a daunting task. Translating literary texts is difficult even for professional translators because misinterpreting the messages of the source texts can lead to distorting the aesthetic aspects of the literary work. Students need to learn various linguistic levels of literary translation as well as strategies and methods of translation. Learning the linguistics levels of translation necessitates providing adequate training that is based on enhancing students’ cognitive abilities. Cognitive-based translation training helps students learn the procedures of solving the problems of translating sound and literary devices. Cognitive approaches are relevant to the translation process since cognition implies mental activities that students can use to understand and synthesize the literary text, and reconstruct it creatively. Therefore, the current study aimed at examining the relationship between cognitive teaching methodologies and students’ performance in literary translation. To examine this relationship, qualitative and quantitative data was collected from graduate students at the College of Languages and Translation at Imam Mohammed bin Saud Islamic University (IMAMU University, Riyadh, Saudi Arabia. In addition, corpus data was gathered from authentic literary texts including, novels, short stories, and poetry, to investigate the effect of linguistic analysis and cognitive strategies on the quality of literary translation. Quantitative data was analyzed using the Statistical Package for the

  7. Twitter Fiction: A New Creative Literary Landscape

    Directory of Open Access Journals (Sweden)

    Laila Al Sharaqi

    2016-08-01

    Full Text Available Twitter, synonymous with social networking, has become a successful social platform for the exchange of ideas, news, and information. It has also emerged as an experimental platform through which users explore creative realms of poetic and narrative content, albeit in 140 characters. The real-time tweets are fundamentally unique and increasingly sophisticated. The attention deficit generation of the fast-paced contemporary world has little time on its hands for extended discourse. Brief stories have been told throughout human history, however, the popularity of short stories skyrocketed with the advent of digital story telling. Twitter has now become a frontier medium that allows a unique mode of digital storytelling that facilitates creative literary experimentation. Twitter offers a unique freedom to writers insofar as a tweet can be an entire bite-sized story or even a snapshot of a story that requires readers’ active imagination to complete. Twitter fiction signifies stylistic word economy, compactness, symbolic structure, and implied narrative. Fragmentariness of the story is a marker of Twitter fiction. The proponents of Twitter fiction enjoy the originality, freedom, and diversity of perspectives offered by the Twitter fiction. Critics, however, argue that the mandated 140 character limitation stunts story development and strangulates creativity. This paper examines Twitter fiction and proposes that limited characters stories are the evolutionary answer to the reduced attention span of the tech-savvy generation. Keywords: twitterature, fiction, brevity, literary art

  8. EUGEN SIMION – (LITERARY CRITIC – A FORM OF CHARACTER

    Directory of Open Access Journals (Sweden)

    Dr. Lucian CHIŞU

    2013-05-01

    Full Text Available The article presents the life and activity of one of the greatest contemporary Romanian literary critics. President of the Romanian Academy, member of the French Academy of Art s, Eugen Simion approached the work of classical and contemporary Romanian writers as well as that of international writers such as E. Ionescu, E. Cioran, M. Eliade, P. Popescu.

  9. A Literary Study on Moschus

    Directory of Open Access Journals (Sweden)

    Kyu Jae Lee

    2005-12-01

    Full Text Available Objective : Literary investigation of existing data was conducted to verify effects of Moschus and its herbal acupuncture, and determine quality management through component analysis. Results : Following results were obtained through literary investigation. 1. Deer musk (Moschus is dried navel gland secretions of the adult male musk deer. 2. Moschus is known to be effective for treating various febrile diseases, to revive senses, heart and abdominal pain, complications from cerebral hemorrhage, angina, and others. 3. Single dosage of Moschus is between and should not exceed 1g. Normally taken as powder or pill and may be used externally. 4. Moschus also has protective effects for the liver cells, and experiments revealed possible efficacies for hyperlipidemia, brain damage, hypertension, and etc. 5. For herbal acupuncture usage, Fel Ursi, Bezoar Bovis, and Moschus are used as a mixture (BUM, and it's known to be effective for protecting the liver and treating arthritis. 6. For component analysis of Moschus, aromatic matter 'muscone' should be used as a standard matter.

  10. The oceanic literary reading mind : An impression

    NARCIS (Netherlands)

    Burke, M.

    2016-01-01

    The mind and brain processes of the literary reading mind are most accurately defined as oceanic: the mind is an ocean. This is the essential premise that I put forward in my book Literary Reading, Cognition and Emotion: An Exploration of the Oceanic Mind (Routledge, 2011).1 The statement is of

  11. An Exemplary High School Literary Magazine: "Cinnabar."

    Science.gov (United States)

    Holbrook, Hilary Taylor, Comp.

    One of a series of 20 literary magazine profiles written to help faculty advisors wishing to start or improve their publication, this profile provides information on staffing and production of "Cinnabar," the magazine published by Ward Melville High School, Setauket, New York. The introduction describes the literary magazine contest (and…

  12. 89 ESTABLISHING THE NEXUS BETWEEN LITERARY CRITICISM ...

    African Journals Online (AJOL)

    Prof Alex C Asigbo

    literary critics to base their work on literary theories in order to make their ... years there has been a great surge of such thinking, much of which challenges ... of the effect produced upon the critic by the book he is .... engaging in their work.

  13. Literary Magazines: To Censor or Not?

    Science.gov (United States)

    Mossman, Robert C.

    2007-01-01

    High school teacher Robert C. Mossman asserts that literary magazines reflect and elevate school communities' values. As adviser of his school literary magazine, Mossman encourages students to uphold certain standards for decency, while helping students learn to distinguish between original writing that is specific and thoughtful and writing that…

  14. Classification of authors by literary prestige

    NARCIS (Netherlands)

    Verboord, Marc

    2003-01-01

    In this study, I investigated a new system to classify authors by literary prestige. The notion of ‘canon’ was considered to lackclear theoretical and empirical grounding. Evaluation and classification practices were examined and operationalized from the perspective of literary field theory. The

  15. Structure–activity relationships of the human prothrombin kringle-2 peptide derivative NSA9: anti-proliferative activity and cellular internalization

    OpenAIRE

    Hwang, Hyun Sook; Kim, Dong Won; Kim, Soung Soo

    2006-01-01

    The human prothrombin kringle-2 protein inhibits angiogenesis and LLC (Lewis lung carcinoma) growth and metastasis in mice. Additionally, the NSA9 peptide (NSAVQLVEN) derived from human prothrombin kringle-2 has been reported to inhibit the proliferation of BCE (bovine capillary endothelial) cells and CAM (chorioallantoic membrane) angiogenesis. In the present study, we examined the structure–activity relationships of the NSA9 peptide in inhibiting the proliferation of endothelial cells lines...

  16. Ccdc85C, a causative protein for hydrocephalus and subcortical heterotopia, is expressed in the systemic epithelia with proliferative activity in rats.

    Science.gov (United States)

    Tanaka, Natsuki; Izawa, Takeshi; Takenaka, Shigeo; Yamate, Jyoji; Kuwamura, Mitsuru

    2015-07-01

    Coiled-coil domain containing 85c (Ccdc85c) is a causative gene for spontaneous mutant mouse with non-obstructive hydrocephalus and subcortical heterotopia. Detailed functions of Ccdc85C protein have not been clarified. To reveal roles of Ccdc85C, we examined the distribution and expression pattern of Ccdc85C in the systemic developing organs in rats. Ccdc85C was expressed in various simple epithelia but not stratified epithelia. In the various epithelia, Ccdc85C was localized at cell-cell junctions and its expression was strong at apical junctions. Furthermore, intense expression was seen at developing period and gradually decreased with advancing development. Distribution of Ccdc85C coincides with that of proliferating epithelial cells. These results suggest that Ccdc85C plays an important role in the proliferative property of simple epithelia.

  17. Evaluation of the effects of ethinylestradiol on sexual differentiation in the olvas-GFP/STII-YI medaka (transgenic Oryzias latipes) strain as estimated by proliferative activity of germ cells

    International Nuclear Information System (INIS)

    Hano, Takeshi; Oshima, Yuji; Kinoshita, Masato; Tanaka, Minoru; Mishima, Noriko; Wakamatsu, Yuko; Ozato, Kenjiro; Shimasaki, Yohei; Honjo, Tsuneo

    2011-01-01

    We evaluated the effects of 17(-ethinylestradiol (EE 2 ) on sexual differentiation in transgenic olvas-GFP/STII-YI medaka (Oryzias latipes) in terms of the proliferative activity of germ cells. This strain contains the green fluorescent protein (GFP) gene fused to the regulatory region of the medaka vasa gene, and germ cell-specific expression of GFP can be visualized in living (transparent) individuals. From 0 days post-hatch (0 dph) onwards, juveniles were exposed to graded concentrations of EE 2 (25.2-1710 ng/L) for 35 days. The gonads of live specimens were monitored by measuring their size and calculating their GFP-fluorescence area. GFP-fluorescent area in control females was about 10 times that in control males at 10 days posthatch (dph) whereas the gonadal size of 10 dph males that had been exposed to 158 ng/L of EE 2 significantly increased up to twice the size of control males, indicating that abnormal sexual differentiation towards female might occur in these individuals. Histological examination and identification of the sex-linked marker SL1 indicated that male to female sex reversal occurred at EE 2 exposure ≥45.1 ng/L at 35 dph. These results suggest that observation of proliferative activity of germ cells in the olvas-GFP/STII-YI strain could be applied to facilitated screening fish model to detect adverse effects on sexual differentiation as early as 10 dph juveniles.

  18. Non-Proliferative Diabetic Retinopathy Vision Simulator

    Science.gov (United States)

    ... Oncology Oculoplastics/Orbit Refractive Management/Intervention Retina/Vitreous Uveitis Focus On Pediatric Ophthalmology ... Retinopathy Diagnosis Diabetic Retinopathy Treatment Proliferative Diabetic Retinopathy Vision Simulator Non-Proliferative Diabetic ...

  19. Proliferative myositis: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Sook; Jeon, Ho Jong [Chosun University College of Medicine, Gwangju (Korea, Republic of)

    2002-09-01

    We report a case of proliferative myositis arising in the pectoralis major muscle of a 59-year-old man who presented with palpable mass. The initial clinical impression was a malignant tumor. Ultrasonography revealed the lesion as a spindle-shaped hypoechoic mass, and MR imaging of the left pectoralis major muscle showed hypointensity at T1-weighted imaging, hyperintensity at T2-weighted imaging, and strong enhancement at contrast-enhanced T1-weighted imaging.

  20. Proliferative myositis: a case report

    International Nuclear Information System (INIS)

    Kim, Young Sook; Jeon, Ho Jong

    2002-01-01

    We report a case of proliferative myositis arising in the pectoralis major muscle of a 59-year-old man who presented with palpable mass. The initial clinical impression was a malignant tumor. Ultrasonography revealed the lesion as a spindle-shaped hypoechoic mass, and MR imaging of the left pectoralis major muscle showed hypointensity at T1-weighted imaging, hyperintensity at T2-weighted imaging, and strong enhancement at contrast-enhanced T1-weighted imaging

  1. Gustav Shpet's Literary and Theatre Theory

    OpenAIRE

    Tihanov, Galin

    2007-01-01

    In his paper, "Gustav Shpet's Literary and Theatre Theory," Galin Tihanov introduces Shpet's theoretical work on literature and theatre, until recently little studied. Neither has been sufficient attention paid to Shpet's overall presence on the Russian cultural scene in the 1910s-1930s. As a result, our knowledge and appreciation of the scope of his writings and the variety of Russian literary and theatre life in the first third of the twentieth century have remained less rich and well-infor...

  2. WRITTEN FAITH: LITERARY ELEMENTS OF ITALIAN IMMIGRATION IN SOUTH BRAZIL

    Directory of Open Access Journals (Sweden)

    Maria Catarina Chitolina Zanini

    2013-12-01

    Full Text Available This article aims to present and analyze literary productions drawn up by descendants of Italian settlers in Rio Grande do Sul (Brazil and highlight how religiosity is a recurring theme present in this texts. This is a migration process that has more than a century and the writing activity proved to be a very usable tool in conservation (and construction of collectives or individuals memories for the contemporary generations.

  3. Lifespan extension by preserving proliferative homeostasis in Drosophila.

    Directory of Open Access Journals (Sweden)

    Benoît Biteau

    2010-10-01

    Full Text Available Regenerative processes are critical to maintain tissue homeostasis in high-turnover tissues. At the same time, proliferation of stem and progenitor cells has to be carefully controlled to prevent hyper-proliferative diseases. Mechanisms that ensure this balance, thus promoting proliferative homeostasis, are expected to be critical for longevity in metazoans. The intestinal epithelium of Drosophila provides an accessible model in which to test this prediction. In aging flies, the intestinal epithelium degenerates due to over-proliferation of intestinal stem cells (ISCs and mis-differentiation of ISC daughter cells, resulting in intestinal dysplasia. Here we show that conditions that impair tissue renewal lead to lifespan shortening, whereas genetic manipulations that improve proliferative homeostasis extend lifespan. These include reduced Insulin/IGF or Jun-N-terminal Kinase (JNK signaling activities, as well as over-expression of stress-protective genes in somatic stem cell lineages. Interestingly, proliferative activity in aging intestinal epithelia correlates with longevity over a range of genotypes, with maximal lifespan when intestinal proliferation is reduced but not completely inhibited. Our results highlight the importance of the balance between regenerative processes and strategies to prevent hyperproliferative disorders and demonstrate that promoting proliferative homeostasis in aging metazoans is a viable strategy to extend lifespan.

  4. Literary Censorship: The Changing Standards

    Directory of Open Access Journals (Sweden)

    Laila Al-Sharqi

    2015-11-01

    Full Text Available Censorship is a double-edged sword that has bred legal, political, and moral wrangling across the globe. The basic controversy, which harkens back to ancient times, stems from the motivation and intention of the censoring authority. The censoring authority controls literary and informational contents, based on the promulgated political, moral, religious, and cultural values of the land. Historically, the politicians, judiciary, clergymen, powerful groups, and the public at large were involved in guarding public morals and rooting out obscenity. The obscenity laws outlawed the selling, purchasing, printing, importing, and mailing of obscene items. However, in today's day and age, the Internet has made it difficult to control the circulation of what was once considered obscene. Censorship has evolved to monitor and control online content to keep abreast with the changing times; nevertheless, it does not always effectively control the questionable content. Moreover, in the past, cultural values and demography played a vital role in deciding what needed to be censored. Internet, as an electronic global village, has redefined demography; therefore, the global as well as indigenous standards upon which literature were once analyzed for censorship is now blurred. The promise of free speech has given power to the people that live in mature democracies. However, there should be a self-imposed code of conduct so that the right of free speech does not infringe on others' right of existence. This paper reviews censorship, tracing its historical path and evolution over the years, its changing standards, and its pros and cons. Lastly, the paper discusses the need to conjoin freedom of speech with the responsibility to protect the diverse cultures, religions, races, sects, genders, and especially the young generation.

  5. Literary Aspects of a Girlie Magazine: The Literary Contributions of Esquire, 1933-43.

    Science.gov (United States)

    Peterson, Thane

    From its inauspicious beginnings as a men's store giveaway and a "girlie" magazine in 1933, "Esquire" magazine quickly established a policy of literary excellence. By 1945, the magazine included the works on such major literary figures as Erskine Caldwell, John Dos Passos, Dashiell Hammett, Ernest Hemingway, Ring Lardner, James…

  6. Estrogen signaling in the proliferative endometrium: implications in endometriosis

    Directory of Open Access Journals (Sweden)

    Rita de Cássia Pereira da Costa e Silva

    2016-02-01

    Full Text Available SUMMARY Even though the physiological role of estrogen in the female reproductive cycle and endometrial proliferative phase is well established, the signaling pathways by which estrogen exerts its action in the endometrial tissue are still little known. In this regard, advancements in cell culture techniques and maintenance of endometrial cells in cultures enabled the discovery of new signaling mechanisms activated by estrogen in the normal endometrium and in endometriosis. This review aims to present the recent findings in the genomic and non-genomic estrogen signaling pathways in the proliferative human endometrium specifically associated with the pathogenesis and development of endometriosis.

  7. Narrativity and enaction: the social nature of literary narrative understanding.

    Science.gov (United States)

    Popova, Yanna B

    2014-01-01

    This paper proposes an understanding of literary narrative as a form of social cognition and situates the study of such narratives in relation to the new comprehensive approach to human cognition, enaction. The particular form of enactive cognition that narrative understanding is proposed to depend on is that of participatory sense-making, as developed in the work of Di Paolo and De Jaegher. Currently there is no consensus as to what makes a good literary narrative, how it is understood, and why it plays such an irreplaceable role in human experience. The proposal thus identifies a gap in the existing research on narrative by describing narrative as a form of intersubjective process of sense-making between two agents, a teller and a reader. It argues that making sense of narrative literature is an interactional process of co-constructing a story-world with a narrator. Such an understanding of narrative makes a decisive break with both text-centered approaches that have dominated both structuralist and early cognitivist study of narrative, as well as pragmatic communicative ones that view narrative as a form of linguistic implicature. The interactive experience that narrative affords and necessitates at the same time, I argue, serves to highlight the active yet cooperative and communal nature of human sociality, expressed in the many forms than human beings interact in, including literary ones.

  8. Narrativity and Enaction: The Social Nature of Literary Narrative Understanding

    Directory of Open Access Journals (Sweden)

    Yanna B. Popova

    2014-08-01

    Full Text Available This paper proposes an understanding of literary narrative as a form of social cognition and situates the study of such narratives in relation to the new comprehensive approach to human cognition, enaction. The particular form of enactive cognition that narrative understanding is proposed to depend on is that of participatory sense-making, as developed in the work of Di Paolo and De Jaegher. Currently there is no consensus as to what makes a good literary narrative, how it is understood, and why it plays such an irreplaceable role in human experience. The proposal thus identifies a gap in the existing research on narrative by describing narrative as a form of intersubjective process of sense-making between two agents, a teller and a reader. It argues that making sense of narrative literature is an interactional process of co-constructing a story-world with a narrator. Such an understanding of narrative makes a decisive break with both text-centered approaches that have dominated both structuralist and early cognitivist study of narrative, as well as pragmatic communicative ones that view narrative as a form of linguistic implicature. The interactive experience that narrative affords and necessitates at the same time, I argue, serves to highlight the active yet cooperative and communal nature of human sociality, expressed in the many forms than human beings interact in, including literary ones.

  9. Evaluation of the anti-proliferative and cytotoxic potentials of ...

    African Journals Online (AJOL)

    The partitioned aqueous and chloroform fractions obtained from the methanol extract of the leaf of Cnidoscolus aconitifolius were examined for anti-proliferative (1-30 mg/mL) and cytotoxic activities (20-400 μg/mL) using the seed radicle inhibition and tadpole mortality assays over a period of 24 and 96 h respectively.

  10. A New Perspective of Literary Criticism

    Directory of Open Access Journals (Sweden)

    Deng Jun

    2009-05-01

    Full Text Available Paratext is a relatively new term in literary criticism, which is mainly elaborated by modern French scholar Gérard Genette. Article presents a qualitative method with its purpose to present a survey to this new literary term and probe into what may lie behind this new critic perspective. Analysis was done by exploring the new literatures in terms of paratext. It can be concluded that paratext has a great influence to the deeper understanding from different perspectives of a literature work. 

  11. LITERARY ACTIVITY OF BORIS PASTERNAK IN CHISTOPOL

    Directory of Open Access Journals (Sweden)

    Galimova, K.N.

    2017-12-01

    Full Text Available The article is devoted to the special stage in the life and work of the world-famous Russian poet, novelist and Literature Nobel Prize winner Boris Pasternak in his three-year evacuation during the World War II in a small town on the Kama River – Chistopol. Special attention is paid to the period of his life when Boris Pasternak was performing a lot of translation work. Within the first two months living in Chistopol the poet translated the play "Romeo and Juliet" by Shakespeare, and then the great cycle of poems by Juliusz Slowacki, runes, the tragedy of Mary Stuart by Shiller. At the same time he brings to life a great idea he had planned long before – the translation of "Antony and Cleopatra". It is also shown that the sketches and drafts of the novel "Doctor Zhivago" which is considered to be the peak of his creative work, had also been prepared in Chistopol.

  12. Literary Language in Development of L2 Competence

    Directory of Open Access Journals (Sweden)

    Dan Lu

    2012-11-01

    Full Text Available Nowadays it is believed that language in daily communication rather than literary language should be the target of learning in L2 education. This is mainly because literary language is said to be uncommon in life. This paper reports on a study in which some Hong Kong ESL learners’ English proficiency was re-examined through literary texts. These learners had reached intermediate or advanced levels of English prior to the study and were generally competent in daily English. However, many of them encountered difficulty in understanding literary language. Their proficiency in general English test could not match their performances in understanding literary works. The findings reveal that learners who are strong in general proficiency may not be good in understanding literary language. Lack of literary language in the curriculum results in a false and distorted picture about the learners’ proficiency. Literary language helps upgrade L2 learners’ real proficiency in the target language.

  13. Problems of Kazakh Literary Criticism Formation

    Directory of Open Access Journals (Sweden)

    Zhandos Smagulov

    2013-01-01

    Full Text Available Тhe article is concerned with the problem of scientific research of Kazakh literature formation in national science. Kazakh literature, having long history of formation is classified by periods. Besides, the article thoroughly considers the principles of the study of methodology, theory, history of spiritual heritage in Kazakh literary criticism

  14. Literary ethnographic writing as sympathetic experiment

    DEFF Research Database (Denmark)

    Dalsgaard, Anne Line

    perhaps only implicitly) of research. But we have no direct access to the subjective world of others and can only inhabit their point of view by way of imagination. Writing literary ethnographic text is one way, I will argue, of experimenting with such sympathetic imagination. By putting together observed...

  15. Proliferative and inflammatory factors in the vitreous of patients with proliferative diabetic retinopathy

    Directory of Open Access Journals (Sweden)

    V V Chernykh

    2015-01-01

    Full Text Available Purpose: The purpose was to measure the concentrations of various cytokines and growth factors (including vascular endothelial growth factor [VEGF] and pigment epithelium-derived factor [PEDF] in the vitreous of patients with proliferative diabetic retinopathy (PDR and to investigate interaction between inflammatory and proliferative factors in the genesis of PDR. Materials and Methods : Vitreous samples from 32 eyes with PDR and 25 eyes without diabetes mellitus and signs of DR (control were collected. Vitreous concentrations of VEGF, PEDF, monocyte chemotactic protein-1 (MCP-1, interleukin-4 (IL-4, IL-6, IL-8, IL-10, IL-17A, and secretory immunoglobulin A (sIgA were simultaneously measured using enzyme-linked immunoassay. Results : Vitreous levels of VEGF, PEDF, IL-17A, IL-6, IL-8, IL-4, and sIgA were significantly (Π < 0.05 higher in eyes with PDR compared to control. The concentration of VEGF was more than 17-times higher than in control, and the concentration of PEDF was not changed oppositely and was also higher (1.45-times compared to control, that may indicate disturbances of compensatory mechanisms in angiogenesis regulation in PDR. Significant (Π < 0.05 positive correlations were observed between vitreous concentrations of VEGF and IL-17ΐ (r = 0.45, VEGF and IL-8 (r = 0.48, VEGF and IL-4 (r = 0.51, PEDF and IL-17ΐ (r = 0.48, PEDF and IL-8 (r = 0.59, MCP-1 and PEDF (r = 0.72, MCP-1 and IL-8 (r0 = 0.45, IL-4 and IL-17ΐ (r = 0.65, IL-4 and IL-8 (r = 0.71, IL-8 and IL-17ΐ (r = 0.59. Conclusions: Significantly raised levels of inflammatory and proliferative factors and numerous positive correlations between them may demonstrate a significant role of activation of vascular proliferation and local inflammation in the pathogenesis of PDR.

  16. Literary and Electronic Hypertext: Borges, Criticism, Literary Research, and the Computer.

    Science.gov (United States)

    Davison, Ned J.

    1991-01-01

    Examines what "hypertext" means to literary criticism on the one hand (i.e., intertextuality) and computing on the other, to determine how the two concepts may serve each other in a mutually productive way. (GLR)

  17. Cytotoxic, Anti-Proliferative and Apoptosis Activity of l-Amino Acid Oxidase from Malaysian Cryptelytrops purpureomaculatus (CP-LAAO) Venom on Human Colon Cancer Cells.

    Science.gov (United States)

    Zainal Abidin, Syafiq Asnawi; Rajadurai, Pathmanathan; Hoque Chowdhury, Md Ezharul; Othman, Iekhsan; Naidu, Rakesh

    2018-06-08

    The aim of this study is to investigate the potential anti-cancer activity of l-amino acid oxidase (CP-LAAO) purified from the venom of Cryptelytrops purpureomaculatus on SW480 and SW620 human colon cancer cells. Mass spectrometry guided purification was able to identify and purify CP-LAAO. Amino acid variations identified from the partial protein sequence of CP-LAAO may suggest novel variants of these proteins. The activity of the purified CP-LAAO was confirmed with o-phenyldiamine (OPD)-based spectrophotometric assay. CP-LAAO demonstrated time- and dose-dependent cytotoxic activity and the EC 50 value was determined at 13 µg/mL for both SW480 and SW620 cells. Significant increase of caspase-3 activity, reduction of Bcl-2 levels, as well as morphological changes consistent with apoptosis were demonstrated by CP-LAAO. Overall, these data provide evidence on the potential anti-cancer activity of CP-LAAO from the venom of Malaysian C. purpureomaculatus for therapeutic intervention of human colon cancer.

  18. Vitrectomy for proliferative diabetic retinopathy

    Directory of Open Access Journals (Sweden)

    Chao Peng

    2013-10-01

    Full Text Available AIM:To observe the clinical effect of vitrectomy for proliferative diabetic retinopathy(PDR.METHODS: The clinical data of 55 cases(65 eyes, underwent vitrectomy, membrane peeling, endolaser photocoagulation and silicone oil or C3F8 injection, were retrospectively studied. During 6 months to 1 year follow-up period, visual acuity, intraocular pressure, retinal conditions and complications were observed.RESULTS: All 65 eyes received vitrectomy, of which silicone oil was tamponaded in 32 eyes, C3F8 was injected in 8 eyes, BBS was filled in 25 eyes. Visual improvement achieved in 42 eyes. Two eyes were manually vision, form count fingers to 0.05 in 18 eyes, >0.05-0.1 in 28 eyes, >0.1-0.3 in 12 eyes and >0.3 in 5 eyes. Retinal hole was occurred in 7 eyes, limitations fibrosis membrane remained in 8 eyes, retinal detachment appeared in 5 eyes, IOP increased in 18 eyes, vitreous hemorrhage relapsed in 12 eyes, 36 eyes received supplemental photocoagulation treatment 1-3 times after operation.CONCLUSION:Vitrectomy combined endophotocoagulation is an effective treatment for PDR. Silicone oil tamponade can limit the hemorrhage.

  19. The KDM5 family is required for activation of pro-proliferative cell cycle genes during adipocyte differentiation

    DEFF Research Database (Denmark)

    Brier, Ann-Sofie B; Loft, Anne; Madsen, Jesper G S

    2017-01-01

    The KDM5 family of histone demethylases removes the H3K4 tri-methylation (H3K4me3) mark frequently found at promoter regions of actively transcribed genes and is therefore generally considered to contribute to corepression. In this study, we show that knockdown (KD) of all expressed members of th...

  20. Proliferative lifespan is conserved after nuclear transfer.

    Science.gov (United States)

    Clark, A John; Ferrier, Patricia; Aslam, Samena; Burl, Sarah; Denning, Chris; Wylie, Diana; Ross, Arlene; de Sousa, Paul; Wilmut, Ian; Cui, Wei

    2003-06-01

    Cultured primary cells exhibit a finite proliferative lifespan, termed the Hayflick limit. Cloning by nuclear transfer can reverse this cellular ageing process and can be accomplished with cultured cells nearing senescence. Here we describe nuclear transfer experiments in which donor cell lines at different ages and with different proliferative capacities were used to clone foetuses and animals from which new primary cell lines were generated. The rederived lines had the same proliferative capacity and rate of telomere shortening as the donor cell lines, suggesting that these are innate, genetically determined, properties that are conserved by nuclear transfer.

  1. Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign.

    Directory of Open Access Journals (Sweden)

    Melissa L Sykes

    Full Text Available Human African Trypanosomiasis (HAT is caused by two trypanosome sub-species, Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Drugs available for the treatment of HAT have significant issues related to difficult administration regimes and limited efficacy across species and disease stages. Hence, there is considerable need to find new alternative and less toxic drugs. An approach to identify starting points for new drug candidates is high throughput screening (HTS of large compound library collections. We describe the application of an Alamar Blue based, 384-well HTS assay to screen a library of 87,296 compounds against the related trypanosome subspecies, Trypanosoma brucei brucei bloodstream form lister 427. Primary hits identified against T.b. brucei were retested and the IC(50 value compounds were estimated for T.b. brucei and a mammalian cell line HEK293, to determine a selectivity index for each compound. The screening campaign identified 205 compounds with greater than 10 times selectivity against T.b. brucei. Cluster analysis of these compounds, taking into account chemical and structural properties required for drug-like compounds, afforded a panel of eight compounds for further biological analysis. These compounds had IC(50 values ranging from 0.22 µM to 4 µM with associated selectivity indices ranging from 19 to greater than 345. Further testing against T.b. rhodesiense led to the selection of 6 compounds from 5 new chemical classes with activity against the causative species of HAT, which can be considered potential candidates for HAT early drug discovery. Structure activity relationship (SAR mining revealed components of those hit compound structures that may be important for biological activity. Four of these compounds have undergone further testing to 1 determine whether they are cidal or static in vitro at the minimum inhibitory concentration (MIC, and 2 estimate the time to kill.

  2. Anti-proliferative and differentiation-inducing activities of the green tea catechin epigallocatechin-3-gallate (EGCG) on the human eosinophilic leukemia EoL-1 cell line.

    Science.gov (United States)

    Lung, H L; Ip, W K; Wong, C K; Mak, N K; Chen, Z Y; Leung, K N

    2002-12-06

    A novel approach for the treatment of leukemia is the differentiation therapy in which immature leukemia cells are induced to attain a mature phenotype when exposed to differentiation inducers, either alone or in combinations with other chemotherapeutic or chemopreventive drugs. Over the past decade, numerous studies indicated that green tea catechins (GTC) could suppress the growth and induce apoptosis on a number of human cancer cell lines. However, the differentiation-inducing activity of GTC on human tumors remains poorly understood. In the present study, the effect of the major GTC epigallocatechin-3-gallate (EGCG) on the proliferation and differentiation of a human eosinophilc leukemic cell line, EoL-1, was examined. Our results showed that EGCG suppressed the proliferation of the EoL-1 cells in a dose-dependent manner, with an estimated IC(50) value of 31.5 microM. On the other hand, EGCG at a concentration of 40 microM could trigger the EoL-1 cells to undergo morphological differentiation into mature eosinophil-like cells. Using RT-PCR and flow cytometry, it was found that EGCG upregulated the gene and protein expression of two eosinophil-specific granule proteins, the major basic protein (MBP) and eosinophil peroxidase (EPO), in EoL-1 cells. Taken together, our findings suggest that EGCG can exhibit anti-leukemic activity on a human eosinophilic cell line EoL-1 by suppressing the proliferation and by inducing the differentiation of the leukemia cells.

  3. Communicating science: professional, popular, literary

    National Research Council Canada - National Science Library

    Russell, N

    2010-01-01

    ... patterns of communication among scientists, popular communication to the public and science in literature and drama. This three-part framework shows how historical and cultural factors operate in today's complex communication landscape, and should be actively considered when designing and evaluating science communication. Ideal for students and p...

  4. Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities.

    Science.gov (United States)

    Zhu, Lijia; Qi, Ji; Chiao, Christine Ya-Chi; Zhang, Qiang; Porco, John A; Faller, Douglas V; Dai, Yan

    2014-11-01

    SIRT1, a class III histone deacetylase, plays a critical role in regulating cancer cell growth, migration and invasion, which makes it a potential target for cancer therapeutics. In this study, we screened derivatives of several groups of natural products and identified a novel SIRT1 inhibitor JQ-101, a synthetic derivative of the polyprenylated acylphloroglucinol (PPAP) natural products, with an IC(50) for SIRT1 of 30 µM in vitro, with 5-fold higher activity for SIRT1 vs. SIRT2. Exposure of tumor cells to JQ-101 significantly enhanced acetylation of p53 and histone H4K16 at known sites of SIRT1 deacetylation, validating SIRT1 as its cellular target. JQ-101 suppressed cancer cell growth and survival by targeting SIRT1, and also exhibited selective cytotoxicity towards a panel of human tumor cell lines, while producing no toxicity in two normal human cell types at comparable concentrations. JQ-101 induced both apoptosis and cell senescence, and suppressed cancer cell invasion in vitro. In summary, we have identified JQ-101 as a new SIRT1 inhibitor which may have potential application in cancer treatment through its ability to induce tumor cell apoptosis and senescence and suppress cancer cell invasion.

  5. Identification of a novel polyprenylated acylphloroglucinol-derived SIRT1 inhibitor with cancer-specific anti-proliferative and invasion-suppressing activities

    Science.gov (United States)

    ZHU, LIJIA; QI, JI; CHIAO, CHRISTINE YA-CHI; ZHANG, QIANG; PORCO, JOHN A.; FALLER, DOUGLAS V.; DAI, YAN

    2014-01-01

    SIRT1, a class III histone deacetylase, plays a critical role in regulating cancer cell growth, migration and invasion, which makes it a potential target for cancer therapeutics. In this study, we screened derivatives of several groups of natural products and identified a novel SIRT1 inhibitor JQ-101, a synthetic derivative of the polyprenylated acylphloroglucinol (PPAP) natural products, with an IC50 for SIRT1 of 30 μM in vitro, with 5-fold higher activity for SIRT1 vs. SIRT2. Exposure of tumor cells to JQ-101 significantly enhanced acetylation of p53 and histone H4K16 at known sites of SIRT1 deacetylation, validating SIRT1 as its cellular target. JQ-101 suppressed cancer cell growth and survival by targeting SIRT1, and also exhibited selective cytotoxicity towards a panel of human tumor cell lines, while producing no toxicity in two normal human cell types at comparable concentrations. JQ-101 induced both apoptosis and cell senescence, and suppressed cancer cell invasion in vitro. In summary, we have identified JQ-101 as a new SIRT1 inhibitor which may have potential application in cancer treatment through its ability to induce tumor cell apoptosis and senescence and suppress cancer cell invasion. PMID:25189993

  6. Assessment of p21, p53 expression, and Ki-67 proliferative activities in the gastric mucosa of children with Helicobacter pylori gastritis.

    Science.gov (United States)

    Saf, Coskun; Gulcan, Enver Mahir; Ozkan, Ferda; Cobanoglu Saf, Seyhan Perihan; Vitrinel, Ayca

    2015-02-01

    Helicobacter pylori that is generally acquired in childhood and infects the gastric mucosa is considered to be responsible for many pathobiological changes that are linked to the pathogenesis of gastric cancer. Although the majority of studies on the subject have been carried out in adults, there are a limited number of studies on children that reflect the early period of infection and may be of greater significance. We aimed to determine the role of H. pylori infection and/or gastritis in several histopathological changes, p53, p21, and cell proliferation-associated Ki-67 antigen expression in the gastric mucosa. We studied 60 patients with a mean age of 7.5 ± 4.5 years at referral. On the basis of endoscopic appearance and the evaluation of the gastric antral specimens, the patients were divided into three groups: patients without gastritis, patients with H. pylori-positive gastritis, and patients with H. pylori-negative gastritis. To determine the expression of p53, Ki-67, and p21 in gastric biopsy specimens, immunohistochemical stains were performed. The incidence of neutrophil activity, which was one of our histopathologic parameters, was significantly higher in the H. pylori-positive gastritis group than the other two groups. The presence of lymphoid aggregate was more frequent in H. pylori ± gastritis groups than the nongastritis group. p53 expression was found to be significantly higher in the H. pylori-positive gastritis group than the nongastritis group. Ki-67 and p21 expressions were significantly more frequent in the H. pylori-positive gastritis group than the other two groups. When we evaluated the density of H. pylori, as the density of bacteria increases, we found that the expressions of p53, p21, and Ki-67 increased significantly. Expression of the studied precancerous markers in significant amounts indicates the importance of childhood H. pylori infection in the constitution of gastric cancer in adulthood.

  7. CULTURAL NATIONALISM AND THE IRISH LITERARY REVIVAL

    Directory of Open Access Journals (Sweden)

    David Pierce

    2002-12-01

    Full Text Available The impact of cultural nationalism on the Insh Literary Revival is a topic of continuing interest for the cultural critic and literary historian alike. In recent years, with the Fa11 of the Berlin Wall, political scientists and others, suchas A.D. Smith, Ernest Gellner, and E.J. Hobsbawm, have also focused on the subject of nationalism. The intention here in this article is to revisit a familiar site in the light of these new ideas and to test their validity or appropriateness in the Irish context. The article, part of a larger project to be published in 2003 by Polity Press under the title A Cultural History of Twentieth-Century Irish Literature, is divided into 5 sections: What ish my Nation?; What is a Nation?; Do Nations Have Navels?; 1890s: Winds of Change; English As We Speak It In Ireland. Among Irish authors discussed are Hyde, Shaw. Yeats, Wilde, Lady Gregory, Joyce, and Beckett.

  8. On the reception of a literary work

    Directory of Open Access Journals (Sweden)

    Jacek Wachowski

    2018-05-01

    Full Text Available The article is an attempt to answer the question: what happens to a literary work – understood as Ingarden’s purely intentional objects – from the recipient’s perspective? And also: how do the images of objects arise in the minds of the audience and what are their properties? Transferring purely intentional objects to the recipient’s perspective changes their status: mental images of objects are subject to numerous fluctuations (based on emotions and cognitive processes. In this way they are transformed into forms that are non-permanent reflections of objects belonging to a literary work. Referring to Ingarden’s terminology, one might say that they become purely intentional reflections (or reflections of purely intentional objects. The article is an attempt to characterize and stratify them.

  9. Marginalia. The Literary Independence of Spanish America

    Directory of Open Access Journals (Sweden)

    Juan Guillermo Gómez García

    2010-12-01

    Full Text Available This article discusses some of the characteristic problems and issues of the so-called “literary independence” of Spanish America in the light of its political emancipation from Spain. This topic goes beyond the temporal framework or the periodization of the wars of independence; instead, it covers the entire nineteenth century and part of the twentieth, and appears discontinuously and non-simultaneously in the different nations. The path followed by Spanish American literature was filled with vicissitudes,manifestations, and regressions of diverse types. The paper specifically analyzes La biblioteca americana and El repertorio americano by the Venezuelan, Andrés Bello, and Juan García del Río, a native of Cartagena, as well as the role of the young Argentinean Domingo F. Sarmiento, author of Facundo, in the genesis and first outlines of an independent Spanish American “literary expression”.

  10. Reading literary fiction improves theory of mind.

    Science.gov (United States)

    Kidd, David Comer; Castano, Emanuele

    2013-10-18

    Understanding others' mental states is a crucial skill that enables the complex social relationships that characterize human societies. Yet little research has investigated what fosters this skill, which is known as Theory of Mind (ToM), in adults. We present five experiments showing that reading literary fiction led to better performance on tests of affective ToM (experiments 1 to 5) and cognitive ToM (experiments 4 and 5) compared with reading nonfiction (experiments 1), popular fiction (experiments 2 to 5), or nothing at all (experiments 2 and 5). Specifically, these results show that reading literary fiction temporarily enhances ToM. More broadly, they suggest that ToM may be influenced by engagement with works of art.

  11. Virginia Woolf's Literary Aesthetics: The Epistemological Aspect

    OpenAIRE

    Bartkuvienė, Linara

    2012-01-01

    The thesis focuses on the epistemological aspect of Virginia Woolf‘s literary aethetics. The research problem of the thesis is an attempt at the conceptualization of the nature of knowledge in Woolf‘s writing and Bertrand Russell‘s philosophy. Methodologically and theoretically, the semantic relationship between Woolf‘s aesthetics and Russell‘s epistemology is closely examined within the framework of the history of ideas. The thesis arrives at the conclusion that Woolf‘s understanding of real...

  12. Cervantes and Vargas Llosa. Two literary architectures

    Directory of Open Access Journals (Sweden)

    Ángel Pérez Martínez

    2017-09-01

    Full Text Available From the development of Literature Theory wich based on the analogy with Architecture the author analyze the relationships between Cervantes and Vargas Llosa works. Research on Cervantes reception in Latin America it is a work to keep doing. In Peru Vargas Llosa has received Cervantes works in a peculiar way. This paper tries to clarify what are the structural relations between these two literary architecture

  13. Parody as a Phenomenon of Literary Criticism

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    Natalіia Naumenko

    2017-11-01

    Full Text Available The article elucidates the properties of a parody as not only an art work, but also as a literary-critical study. There is shown that the parody, according to the creative invention of its author, has the purpose to expose and then to deride the certain disadvantages of on original poetic text; however, in closer reading, it seems to maintain a critical paradigm. First of all, this paradigm reveals all of the noticed flaws as the remedy to make “the creative prophylactics” for a future poet; second, it helps a reader to comprehend as well the positive features of a parodied text (particularly, in reading an original, and also to imagine the image of an author (of either the original or the parody opened to further interpretations. The subjects of studies in this article are Ukrainian literary parodies published throughout the 20th – the beginning of the 21st centuries (authors – Ostap Vyshnia, V. Yaremenko, Yu. Ivakin, A. Bortnyak, I. Havryliuk; there are also analyzed several poetic works that are not parodies a priori, but tend to deride some realia of the authors’ everyday life. There was shown that the efficiency of literary criticism could be defined by not only what the critic said, but also how one did it. Therefore, elucidation of a parody seems to be impossible without studying its generic, stylistic, imagery and compositional characteristics of a potential parody object (original verse work, including the specifications of development of a poet’s individual style within parodying any kind of literary works.

  14. In vitro anti-proliferative effect of interferon alpha in solid tumors: A potential predicative test

    International Nuclear Information System (INIS)

    Fuchsberger, N.; Kubes, M.; Kontsek, P.; Borecky, L.; Hornak, M.; Silvanova; Godal, A.; Svec, J.

    1993-01-01

    An in vitro test for the anti-proliferative effect of human leukocyte interferon (IFN-alpha) was performed in primary cultures of tumor cells obtained from 32 patients with either malignant melanoma (13), renal carcinoma (4) or bladder carcinoma (15). Our results demonstrated activity of IFN in all three groups of solid tumors. However, appreciable differences in sensitivity to anti-proliferative effect of IFN between individual tumors of the same type were found. The potential of this anti-proliferative test for prediction of treatment response in IFN-therapy is discussed. (author)

  15. Retinal vessel caliber as a potential marker of treatment outcome in patients with proliferative diabetic retinopathy

    DEFF Research Database (Denmark)

    Vergmann, Anna Stage; Torp, Thomas Lee; Lundberg, Kristian

    Title of abstract: Retinal vessel caliber as a potential marker of treatment outcome in patients with proliferative diabetic retinopathy Design of study: Three months prospective, interventional clinical study. Purpose: The retinal vascular tree can be measured non-invasively and summarized...... into the central retinal artery and vein equivalent (CRAE and CRVE). The purpose of this study was to evaluate retinal calibers as biomarkers for disease activity 3 months after panretinal photocoagulation (PRP) in patients with proliferative diabetic retinopathy (PDR). Methods: Fifty one eyes from 40 newly...... with proliferative diabetic retinopathy....

  16. A Review on Developing Critical Thinking Skills through Literary Texts

    Directory of Open Access Journals (Sweden)

    Noraini Ahmad Shukri

    2015-04-01

    Full Text Available Many ESL instructors are generally in agreement with the belief that it is essential that students should be assisted in developing critical thinking skills while being engaged in their language learning process especially those learning the target language at higher level (Stern, 1985; Dickinson, 1991; McKay, 2001; Terry, 2007; Van, 2009; Odenwald, 2010. As it enables language learners to engage in a more purposeful and self-regulatory in judgment, helping them in their evaluation of the arguments of others and of their own, coming to well-reasoned resolutions to any complex problems and to be able to resolve conflicts encountered in their daily lives. Critical thinking requires them to be actively involved in their own learning process as they attempt to individually understand and apply the information they are exposed to during the classroom interaction (Landsberger, 1999; Tung & Chang, 2009. The many advantageous and feasibility of teaching instruction that incorporates the study of literature in the ESL classroom which suggests that literature texts, if correctly chosen and instructed, can prove to be beneficial to ESL students’ overall level of literacy and critical thinking skills. Numerous empirical researches also asserted that literary texts that are authentic, enjoyable, and motivating would naturally increase both their knowledge of the target language patterns and cultural awareness. Keywords: Critical thinking, ESL classroom, literature, literary text

  17. Nooruse valuuta. „Noorkirjanik“ ja „rühmitus“ nullindatel / The Currency of Youth. The "Young Author" and the "Literary Group" in the 2000s

    Directory of Open Access Journals (Sweden)

    Priit Kruus

    2013-06-01

    Full Text Available The article is focused on literary groups and the emergence of young authors in the 2000s. So far literary researchers have mainly studied the influential literary groups of the first third of the 20th century (Noor-Eesti, Siuru, Tarapita etc.. But literary groups have had a remarkable impact on contemporary Estonian literature as well. Many present-day well-known writers entered the literary scene through groups which were active in the 1990s (e.g. TNT and Erakkond. In the 2000s forming a literary group lost its appeal as young authors found more individual ways to introduce themselves to the public. At the beginning of the 2000s a couple of attempts were made to form new literary groups, but those groups were short-lived and unproductive (e.g. TNT! and !peatus.Young authors were very active in publishing both on paper and online. The emergence of new publishing channels is one of the reasons why young authors did not have the ambition or need to form groups. For example, in the 2000s literary debuts appeared in the web-based literary club POOGEN and the literary magazine Värske Rõhk (established in 2005. So the 2000s actually saw a new type of convergence: web-based literary clubs and forums. Unfortunately, many of the new channels of the 2000s are already out of reach: the web pages of KLOAAK, noortekas.delfi.ee, People&Poetry, Bahama Press and ThePression have been removed from the internet.Debuts were welcomed by mainstream media eager to spot the next big thing, new rebels and rule breakers. Being “a young author” became a functioning brand, and youth became a form of currency for beginning writers.

  18. Proliferation Index and Karyometric Features of Pancreatic Intraductal Proliferative Lesions

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    Romana Tomaszewska

    1999-01-01

    Full Text Available The increasing frequency and poor prognosis in pancreatic cancer prompt us to search for morphological lesions being a substrate for its development. Studies of autopsy and surgically resected material as well as recent molecular studies have proved that one of the possible pathways of pancreatic neoplasia is the intraepithelial proliferation – dysplasia – cancer sequence. In the present paper we studied the proliferative activity (Ki‐67 index in pancreatic intraepithelial proliferative lesions and its correlation with geometric features of cell nuclei as signs of increasing dysplasia. The studies were carried out in a group of 35 patients operated on for pancreatic cancer, chronic pancreatitis and other conditions not associated with the pancreas. We used immunohistochemical methods and basic morphometric parameters. The results of our studies indicate that the cell proliferative activity depends both on the type of epithelial proliferation and underlying pancreatic disease. The values of Ki‐67 index are significantly different in low‐grade proliferation (flat and papillary hyperplasia and high‐grade proliferation (atypical papillary hyperplasia and carcinoma in situ. A set of karyometric features correlates with Ki‐67 index but there is no single feature which would have a diagnostic value.

  19. Endothelin-1 is associated with fibrosis in proliferative diabetic retinopathy membranes.

    Science.gov (United States)

    Chang, William; Lajko, Michelle; Fawzi, Amani A

    2018-01-01

    To characterize the relationship between endothelin-1 and fibrosis in epiretinal membranes in proliferative diabetic retinopathy and explore the role of endothelial-mesenchymal transition in these membranes. Membranes were obtained from eyes undergoing pars plana vitrectomy for complicated proliferative diabetic retinopathy or idiopathic epiretinal membrane. Through standard immunohistochemical techniques, we labeled membranes to explore the distribution of endothelin-1 and endothelin receptor B, comparing proliferative diabetic retinopathy and idiopathic epiretinal membranes. In addition, membranes were also labeled with markers for fibroblasts, endothelial, and glial cells and studied with confocal laser scanning microscopy. The intensity of endothelin-1 labeling was quantified using standard image analysis software. Fourteen membranes were included in the analysis, nine from eyes with proliferative diabetic retinopathy and five idiopathic membranes. Flatmount diabetic membranes showed co-localization of endothelin-1 with S100A4 and CD31. Immunohistochemistry and quantitative analysis of cross-sectional membranes showed significantly higher endothelin-1 labeling in proliferative diabetic retinopathy membranes compared to idiopathic membranes (pmembranes showed more elements staining positive for S100A4 compared to idiopathic membranes. Epiretinal membrane formation in proliferative diabetic retinopathy involves higher tissue levels of endothelin-1 and fibroblastic activity. Furthermore, endothelin-1, endothelial and fibroblastic staining appear to be correlated, suggestive of endothelial-to-mesenchymal transition in proliferative diabetic retinopathy.

  20. Approaches and Methods of Periodization in Literary History

    Directory of Open Access Journals (Sweden)

    Naser Gholi Sarli

    2013-10-01

    Full Text Available Abstract One of the most fundamental acts of historiography is to classify historical information in diachronic axis. The method of this classification or periodization shows the theoretical approach of the historian and determines the structure and the form of his history. Because of multiple criteria of analysis and various literary genres, periodization in literary history is more complicated than that of general history. We can distinguish two approaches in periodization of literary history, although these can be used together: extrinsic or social-cultural approach (based on criteria extrinsic to literature and intrinsic or formalist approach (based on criteria intrinsic to literature. Then periodization in literary history can be formulated in different methods and may be based upon various criteria: chronological such as century, decade and year organic patterns of evolution great poets and writers literary emblems and evaluations of every period events, concepts and periods of general or political history analogy of literary history and history of ideas or history of arts approaches and styles of language dominant literary norms. These methods actually are used together and everyone has adequacy in special kind of literary history. In periodization of Persian contemporary literature, some methods and models current in periodization of poetry have been applied identically to periodization of prose. Periodization based upon century, decade and year is the simplest and most mechanical method but sometimes certain centuries in some countries have symbolic and stylistic meaning, and decades were used often for subdivisions of literary history, especially nowadays with fast rhythm of literary change. Periodization according to organic patterns of evolution equates the changes of literary history with the life phases of an organism, and offers an account of birth, mature and death (and sometimes re-birth of literary genres, but this method have

  1. Approaches and Methods of Periodization in Literary History

    Directory of Open Access Journals (Sweden)

    Dr. N. Gh. Sarli

    Full Text Available One of the most fundamental acts of historiography is to classify historical information in diachronic axis. The method of this classification or periodization shows the theoretical approach of the historian and determines the structure and the form of his history. Because of multiple criteria of analysis and various literary genres, periodization in literary history is more complicated than that of general history. We can distinguish two approaches in periodization of literary history, although these can be used together: extrinsic or social-cultural approach (based on criteria extrinsic to literature and intrinsic or formalist approach (based on criteria intrinsic to literature. Then periodization in literary history can be formulated in different methods and may be based upon various criteria: chronological such as century, decade and year; organic patterns of evolution; great poets and writers; literary emblems and evaluations of every period; events, concepts and periods of general or political history; analogy of literary history and history of ideas or history of arts; approaches and styles of language; dominant literary norms. These methods actually are used together and everyone has adequacy in special kind of literary history. In periodization of Persian contemporary literature, some methods and models current in periodization of poetry have been applied identically to periodization of prose. Periodization based upon century, decade and year is the simplest and most mechanical method but sometimes certain centuries in some countries have symbolic and stylistic meaning, and decades were used often for subdivisions of literary history, especially nowadays with fast rhythm of literary change.Periodization according to organic patterns of evolution equates the changes of literary history with the life phases of an organism, and offers an account of birth, mature and death (and sometimes re-birth of literary genres, but this method have

  2. Approaches and Methods of Periodization in Literary History

    Directory of Open Access Journals (Sweden)

    Naser Gholi Sarli

    2013-11-01

    Full Text Available Abstract One of the most fundamental acts of historiography is to classify historical information in diachronic axis. The method of this classification or periodization shows the theoretical approach of the historian and determines the structure and the form of his history. Because of multiple criteria of analysis and various literary genres, periodization in literary history is more complicated than that of general history. We can distinguish two approaches in periodization of literary history, although these can be used together: extrinsic or social-cultural approach (based on criteria extrinsic to literature and intrinsic or formalist approach (based on criteria intrinsic to literature. Then periodization in literary history can be formulated in different methods and may be based upon various criteria: chronological such as century, decade and year organic patterns of evolution great poets and writers literary emblems and evaluations of every period events, concepts and periods of general or political history analogy of literary history and history of ideas or history of arts approaches and styles of language dominant literary norms. These methods actually are used together and everyone has adequacy in special kind of literary history. In periodization of Persian contemporary literature, some methods and models current in periodization of poetry have been applied identically to periodization of prose. Periodization based upon century, decade and year is the simplest and most mechanical method but sometimes certain centuries in some countries have symbolic and stylistic meaning, and decades were used often for subdivisions of literary history, especially nowadays with fast rhythm of literary change. Periodization according to organic patterns of evolution equates the changes of literary history with the life phases of an organism, and offers an account of birth, mature and death (and sometimes re-birth of literary genres, but this method have

  3. Literary Routes: Contributions to Natural/Cultural Heritage Tourism. How landscape transforms literature and tourism

    Directory of Open Access Journals (Sweden)

    Rosalinda Ruiz Scarfuto

    2013-12-01

    Full Text Available Literary routes inspired by landscapes is a topic where cultural and natural routes merge to form an added value of heritage that is greater than either one standing alone.  Landscape is traditionally defined as a consequence of transformations by humans, and its scope rarely takes into account how nature has inspired literature to advance the “intellectual development of humankind,” hence transforming heritage.  Literary routes paralleling transhumance routes embraced by the Sami, First Nations, or Spanish shepherds (full of landscapes, seascapes, and riverscapes, can actively transmit traditional technologies, biodiversity, and cosmic philosophy for the betterment of humankind; for example, the depth of literary heritage inspired by landscapes enhances our collective memory through a network of archives (libraries, collections.  The continuous dissemination of this literature traversing borders, language barriers, and time periods has stimulated literary routes to emerge as a function of moving the experience from an intangible heritage based on imaginary landscapes to a tangible sensory experience in situ following a plot, author’s life, or a myth. Literary routes respond to the demand of the growing target travellers, who are more literate and active today than in the past. They are excited followers of their favourite writers, and seek ways to be in contact with them. Now it is time to rekindle the collective memory, expand the literary dimension, and offer a sensorial in situ experience by adding a literary link. For instance, myths of the Ohlone Nation based near a California wetlands use the symbolic coyote as the intermediary to teach humans how to live in harmony with their ecosystem; or in Spain, Arcipreste de Hita’s novel El Libro de Buen Amor (1330 describes traditions and gastronomy as it criss-crosses the Guadarrama mountains, alongside the Poets’ Route that includes international Nobel prize winners in literature

  4. Semiotics of Umberto Eco in a Literary Translation Class: The Model Reader as the Competent Translator

    Science.gov (United States)

    Ozturk Kasar, Sündüz; Can, Alize

    2017-01-01

    Classroom environment can be thought as an absolute place to practice and improve translation skills of students. They have the possibility to brainstorm and discuss problematic points they face with each other during a translation activity. It can be estimated in the same way in a literary translation class. Students who are supposed to become…

  5. Reacting in Literary Studies: Crossing the Threshold from Quality to Meaning

    Science.gov (United States)

    Heinert, Jennifer; Chick, Nancy L.

    2017-01-01

    In this essay, the authors extend their ongoing conversations within the overarching project on "critique as signature pedagogy in the arts and humanities" by considering how the position of literary studies within this broader context may explain some of the difficulties students have with a cornerstone activity of the undergraduate…

  6. Literary Research and Canadian Literature: Strategies and Sources. Literary Research--Strategies and Sources #10

    Science.gov (United States)

    Reznowski, Gabriella

    2011-01-01

    Canada's rich literary heritage, dominated by a multicultural and multilingual presence, reflects the country's unique history and experience. In addition, an emerging body of new writers is redefining both the geographic and metaphorical boundaries of Canadian literature. Coupled with the propagation of digital technologies, Canada's burgeoning…

  7. Fascinating! Popular Science Communication and Literary Science Fiction

    DEFF Research Database (Denmark)

    Meyer, Gitte

    2017-01-01

    Some see literary Science Fiction as a possible vehicle for critical discussions about the future development and the ethical implications of science-based technologies. According to that understanding, literary Science Fiction constitutes a variety of science communication. Along related lines, ......, popular science communication with science fiction features might be expected to serve a similar purpose. Only, it is far from obvious that it actually works that way.......Some see literary Science Fiction as a possible vehicle for critical discussions about the future development and the ethical implications of science-based technologies. According to that understanding, literary Science Fiction constitutes a variety of science communication. Along related lines...

  8. Proliferative and morphologic changes in rat colon following bypass surgery.

    Science.gov (United States)

    Barkla, D H; Tutton, P J

    1985-06-01

    In this study the proliferative and morphologic changes that occur in the colon of normal and dimethylhydrazine-treated rats following surgical bypass of the middle third of the colon are reported. Proliferative changes were measured by estimating accumulated mitotic indexes following vinblastine treatment and morphologic changes were observed with the use of light microscopy and scanning electron microscopy. Data were collected on Days 0, 7, 14, 30, and 72 after surgery. The results show that surgical bypass produces contrasting effects in the segments proximal to and distal to the suture line. In the proximal segment there was morphologic evidence of hyperplasia, although proliferative activity was unchanged except for an increase at 7 days in normal rats. In the distal segment there was a long-lived increase in the mitotic index, although morphologic changes were not seen. The results for DMH-treated rats were similar to those in normal rats. Groups of isolated dysplastic epithelial cells were often seen in the submucosa adjacent to sutures up to 72 days after surgery. Increased lymphoid infiltration was seen in segments proximal to but not distal to the suture line. It is hypothesized that the different responses of the proximal and distal segments may be related to the different embryologic origins of those segments. It is also hypothesized that the seeding of the submucosa with epithelial cells during suturing may be a factor in tumor recurrence.

  9. Finding Feminist Literary Reading: Portrayals Of Women In The 1920s Indonesian Literary Writings

    Directory of Open Access Journals (Sweden)

    Diah Ariani Arimbi

    2014-12-01

    Full Text Available Abstract: Modern Indonesian literature can be said to be born around 1920s with the publication of modern Indonesian literary works by Balai Pustaka. Amongst the works published by Balai Pustaka in the 1920s ; there are most popular works namely Sitti Nurbaya (1922 ; Azab dan Sengsara(1927 and Salah Asuhan (1928 representing the tone of 1920s literary productions. This paper aims to look at images of women in those three works written by male authors ; using feminist literary criticism. By means of close reading technique; the study uses feminist literary criticism to examine and (reexamine the images of women portrayed in those three works. The finding shows that on one hand some women are still trapped with the shackle of patriarchy, but, on the other hand, some women are not simply passive victims of patriarchy: these women still attempt to escape from the patriarchal chain and cut out the patriarchal oppression. Key Words: modern Indonesian literature; 1920s; Balai Pustaka; women; feminist literary criticism Abstrak: Sastra Indonesia modern dapat dikatakan lahir sekitar tahun1920-an dengan publikasi karya sastra Indonesia modern oleh Balai Pustaka. Di antara karya yang diterbitkan oleh Balai Pustaka pada tahun 1920-an; terdapat karya yang paling populer seperti Sitti Nurbaya (1922; Azab dan Sengsara (1927; dan Salah Asuhan (1928 yang mewakili suara produksi sastra tahun 1920-an. Makalah ini bertujuan untuk melihat potret perempuan dalam tiga karya yang ditulis oleh penulis laki-laki dengan menggunakan pendekatan kritik sastra feminis. Melalui teknik pembacaan yang mendalam (close reading technique; penelitian ini menggunakan kritik sastra feminis untuk menelaah potret perempuan dalam tiga karya tersebut. Temuan dalam tulisan ini menunjukkan bahwa di satu sisi perempuan masih terbelenggu oleh patriarkat; tetapi di sisi lain perempuan bukanlah korban patriarkat yang pasif: perempuan tetap berupaya untuk keluar dari belenggu ini dan memutus

  10. Literary Fiction Influences Attitudes Toward Animal Welfare.

    Science.gov (United States)

    Małecki, Wojciech; Pawłowski, Bogusław; Sorokowski, Piotr

    2016-01-01

    Literary fiction has been credited with considerable power to improve attitudes toward outgroups. It was even argued that it has been an important factor behind the global decline of violence against various minorities in the last centuries. Could it also help to reduce the human-inflicted suffering of animals? To test this, we studied the attitude toward animal welfare of n = 921 (experimental group) people of both sexes who read a short fragment of an unpublished novel with a motif of the physical abuse of an animal. The control group (n = 912) read a fragment of a similar length but not related to animals. After reading the text all subjects filled out an on-line questionnaire with seven items (camouflaged among many others items) measuring attitudes toward animal welfare. The questionnaire included also demographical questions, such as whether the subject keeps pets. We found that in comparison with the control group, the experimental group was significantly more concerned about animal welfare. This result indicates that literary fiction can influence attitudes toward other species. It is also worth noting that our study is characterized by a high level of ecological validity, i.e. a relatively high extent to which its results can be generalized (or extended) to real-world settings. Due to its specific design, which involved the cooperation of a bestselling author and his publisher, the study approximated the typical conditions in which people read fiction in a remarkably accurate way. Finally, our research has potential practical implications for promoting animal welfare.

  11. A Classification Scheme for Literary Characters

    Directory of Open Access Journals (Sweden)

    Matthew Berry

    2017-10-01

    Full Text Available There is no established classification scheme for literary characters in narrative theory short of generic categories like protagonist vs. antagonist or round vs. flat. This is so despite the ubiquity of stock characters that recur across media, cultures, and historical time periods. We present here a proposal of a systematic psychological scheme for classifying characters from the literary and dramatic fields based on a modification of the Thomas-Kilmann (TK Conflict Mode Instrument used in applied studies of personality. The TK scheme classifies personality along the two orthogonal dimensions of assertiveness and cooperativeness. To examine the validity of a modified version of this scheme, we had 142 participants provide personality ratings for 40 characters using two of the Big Five personality traits as well as assertiveness and cooperativeness from the TK scheme. The results showed that assertiveness and cooperativeness were orthogonal dimensions, thereby supporting the validity of using a modified version of TK’s two-dimensional scheme for classifying characters.

  12. Criticism of the narrative works of Gabriel García Márquez in Serbian literary magazines

    Directory of Open Access Journals (Sweden)

    Vesna Z Dickov

    2014-12-01

    Full Text Available Since the Serbian translation of the novel One Hundred Years of Solitude appeared in 1973, the narrative works of Gabriel García Márquez have continued to interest Serbian critics. After an initial break with readers’ expectations, criticism of the magical realism and other aspects of the prose of García Márquez soon (from 1975 began to develop in Serbia, and intensified in the later seventies of the last century as well as at the end of the first decade of the 21st century, when a series of essays, reviews, articles and studies were published on the novels, stories, reportages, essays and memoirs of García Márquez, including his journalistic work. Half of the texts written by Serbian critics for literary journals came out in Belgrade, especially in Književna reč (The Literary Word, the most prolific authors being Radomir Ivanović and Branko Anđić. The judgment of Serbian critics, presented in the literary magazines, which was based frequently on the latest advances in narratology, genealogy and comparative literature, has contributed greatly to the shaping of readers’ expectations not only regarding Gabriel García Márquez’s prose but also new Latin American narrative in general.

  13. Revisiting Style, a Key Concept in Literary Studies

    NARCIS (Netherlands)

    Herrmann, J. Berenike; van Dalen-Oskam, K.H.; Schöch, Christof

    2015-01-01

    Language and literary studies have studied style for centuries, and even since the advent of ›stylistics‹ as a discipline at the beginning of the twentieth century, definitions of ›style‹ have varied heavily across time, space and fields. Today, with increasingly large collections of literary texts

  14. Girl-Child Education and Nigeria's Development Agenda: a Literary ...

    African Journals Online (AJOL)

    We have therefore taken a literary trajectory of select literary female characters with a view to positioning them against the background of their access or otherwise to education (formal and informal), and how this plays out in the shaping of their lives vis-à-vis the Nigerian girl-child's prospect of enhancing herself with a view ...

  15. Painting local colour: a sociolinguistic disposition of the literary artist ...

    African Journals Online (AJOL)

    Literary artists have advanced human ways of life through their writings. Hence, literature as a work of art merely lends credence to these persuasions by literary artists. It is possible to describe 'Culture' as the art, literature, music and other intellectual expressions of a particular society or time. Therefore, literature being an ...

  16. Empathy at the confluence of neuroscience and empirical literary studies

    NARCIS (Netherlands)

    Burke, M.; Mangen, Anne; Kuzmicova, Anezka; Schilhab, Theresa

    2016-01-01

    The objective of this article is to review extant empirical studies of empathy in narrative reading in light of (a) contemporary literary theory, and (b) neuroscientific studies of empathy, and to discuss how a closer interplay between neuroscience and literary studies may enhance our understanding

  17. Crime Writing in Southern Africa: A Literary Example of the ...

    African Journals Online (AJOL)

    Crime writing, long time considered to be of minor quality, generally seeks to reach a large audience. As a literary genre it entered Western history around the 1850s. Literary critics view the origins of this genre in the economic, political and cultural developments of the 19th Century based on various sociological data, ...

  18. An Exemplary High School Literary Magazine: "Et Cetera."

    Science.gov (United States)

    Holbrook, Hilary Taylor, Comp.

    One of a series of 20 literary magazine profiles written to help faculty advisors wishing to start or improve their publication, this profile provides information on staffing and production of "Et Cetera," the magazine published by Clarkstown High School, New City, New York. The introduction describes the literary magazine contest (and…

  19. An Exemplary High School Literary Magazine: "The Thinking Reed."

    Science.gov (United States)

    Holbrook, Hilary Taylor, Comp.

    One of a series of 20 literary magazine profiles written to help faculty advisors wishing to start or improve their publication, this profile provides information on staffing and production of "The Thinking Reed," the magazine published by Bethlehem Central High School, Delmar, New York. The introduction describes the literary magazine…

  20. Using Literary Texts to Teach Grammar in Foreign Language Classroom

    Science.gov (United States)

    Atmaca, Hasan; Günday, Rifat

    2016-01-01

    Today, it is discussed that the use of literary texts in foreign language classroom as a course material isn't obligatory; but necessary due to the close relationship between language and literature. Although literary texts are accepted as authentic documents and do not have any purpose for language teaching, they are indispensable sources to be…

  1. Application of Freudian Concepts to the Explication of Literary Texts ...

    African Journals Online (AJOL)

    This article established and proved the age old relationship between. Psychology and Literature together with the application of Freudian concepts to the explication of literary texts. The interest of literary critics from Sigmund Freud to Jacques Lacan has been noticeable and remarkable in the field of psychoanalytic criticism.

  2. Reading Minds: Using Literary Resources in Family Therapy.

    Science.gov (United States)

    Burns, Liz

    A qualitative enquiry explored, with a range of family therapists and systemic practitioners, the influence they perceive to have been made on their personal and professional lives by the literary texts they have read. Noting that "literary" is broadly interpreted to include poetry, prose, drama/film, song lyrics, etc., the study's aims…

  3. Literary translation into indigenous languages in Nigeria and ...

    African Journals Online (AJOL)

    This study makes out a case for the thorny problem of literary translation into Nigeria's indigenous languages and its role in national development. In this paper, we outline the way forward given the fact that literary translation into Nigerian languages had gone through a sticky patch. Federal, State and Local governments in ...

  4. A canonical-literary reading of Lamentations 5 | Kang | HTS ...

    African Journals Online (AJOL)

    This article presents a canonical and literary reading of Lamentations 5 in the context of the book of Lamentations as a whole. Following the approach by Vanhoozer (1998, 2002) based on speech-act theory, the meaning of Scripture is sought at canonical level, supervening the basic literary level. In Lamentations, as ...

  5. Literary Studies: A Preparation for Tertiary Education (and Life Beyond)

    Science.gov (United States)

    Zabka, Thomas

    2016-01-01

    My argument is that a literary education should build on a primary level of responsivity towards literature, involving empathy and immersion in the world of the text. To engage with literary works from the past involves a play between familiarity and strangeness, and this play should be located as part of a reader's response to texts, rather than…

  6. Walking Through the Revolution: A Spatial Reading of Literary Echoes

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    Ana Isabel Queiroz

    2015-05-01

    Full Text Available This paper presents an embryo of a literary guide on the Carnation Revolution to be explored for educational historical excursions other than leisure and tourism. We propose a historical trail through the centre of Lisbon, city of the Carnation Revolution, called Walk through the Revolution. The trail aims to reinforce collective memory about the major events that occurred in the early moments leading to the coup. The trail is made up by nine places of rememberance, for which literary excerpts are suggested and which are supported by a digital research procedure. A set of seven fixed and observer-independent categories are used to analyse the literary contents of 23 literary works published up to 2013. These literary works refer to events that happened between the eve of April 25 and May 1, 1974. At the same time, literary descriptions are explored using a spatial approach in order to define the literary geography of the most iconic military actions and popular demonstrations that occurred in Lisbon and the surroundings. The literary geography and the cartography of the historical events are then compared. Data analysis and visualization benefit from the use of standardised and quantitative methods, including basic statistics and geographic information systems.

  7. Peeling the Onion: Student Teacher's Conceptions of Literary Understanding.

    Science.gov (United States)

    Carlsson, Maj Asplund; Fulop, Marta; Marton, Ference

    2001-01-01

    Studied the theories student teachers held about literary understanding through interviews with 25 Hungarian and 8 Swedish student teachers. Categories of theories captured a substantial portion of the variation in how literary understanding can be seen. Three central aspects of human understanding, variation, discernment, and simultaneity, could…

  8. The Early Literary Reception of Ernest Hemingway in Iran

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    Atefeh Ghasemnejad

    2018-01-01

    Full Text Available This essay investigates the dynamics that led to the literary reception of Ernest Hemingway before the Islamic Revolution in Iran. This article deploys reception studies as a branch of Comparative Literature with a focus upon conceptions of Siegbert Salomon Prawer and the practical method of George Asselineau to unearth the ideological, political, and historical milieu that embraced Hemingway’s literary fortune in Iran. This investigation, unprecedented in the study of Iranian literature, discusses how and why Hemingway was initially received in Iran. As such, the inception of literary fortune of Ernest Hemingway in Iran is examined by the contextual features, Persian literary taste, and the translator’s incentives that paved the way for this reception. This article also uncovers the reasons for the delay in the literary reception of Hemingway in Iran and discussed why some of Hemingway’s oeuvres enjoyed recognition while others were neglected by the Iranian readership.

  9. Labouring Under The Stone—A Literary Legacy of Lithiasis

    Science.gov (United States)

    Moran, Michael E.

    2007-04-01

    The history of mankind's suffering greatly from calculus disease has been one of excruciating longevity. Since the first historical records, humans have formed stones and endured the wrath of these concretions' passage via the delicate mechanisms of the urinary tract. This study involved detailed investigations of historical writings of famous stone sufferers to better appreciate the circumstances of our patients. Collected histories both of textbooks and articles were scrutinized for the accounts of famous stone sufferers. Once identified, primary resources were sought with English translations given preference. Cross-referencing all informational sources was attempted. The accounts were then classified as lower urinary tract (BS), upper urinary tract (KS), by century of the individual, and whether these were ancient (before 100 years ago) or recent (from the 20th Century onwards). Many of these great men and woman suffered in relative silence. Not much is available on descriptions of their colic. However, there are others such as Michel Montaigne, Erasmus of Rotterdam, Benjamin Franklin, Thomas Sydenham, Sir William Osler and Richard Selzer who were able to transform their suffering into ethereal expressions of pure pain and suffering. The ancient descriptions are twofold fascinating, as the victims of stone disease faced quackery and profound ignorance from the medical profession and no effective remedy for the pain. Here again, there are two typical responses: the enlightened cerebral concerns of Montaigne, Sydenham, and Franklin versus the punitive, religious overtones from Erasmus and Pepys. Lower and upper tract stones produced equal horrors to those once thought to incur punishment from the gods, or turning to stone-like "living statues." No amount of literary expression can capture the true essence of renal colic. Medical texts from their earliest times place stone passage near the top of the pantheon of medical suffering. Each of these prolific and

  10. Literary Fiction Influences Attitudes Toward Animal Welfare.

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    Wojciech Małecki

    Full Text Available Literary fiction has been credited with considerable power to improve attitudes toward outgroups. It was even argued that it has been an important factor behind the global decline of violence against various minorities in the last centuries. Could it also help to reduce the human-inflicted suffering of animals? To test this, we studied the attitude toward animal welfare of n = 921 (experimental group people of both sexes who read a short fragment of an unpublished novel with a motif of the physical abuse of an animal. The control group (n = 912 read a fragment of a similar length but not related to animals. After reading the text all subjects filled out an on-line questionnaire with seven items (camouflaged among many others items measuring attitudes toward animal welfare. The questionnaire included also demographical questions, such as whether the subject keeps pets. We found that in comparison with the control group, the experimental group was significantly more concerned about animal welfare. This result indicates that literary fiction can influence attitudes toward other species. It is also worth noting that our study is characterized by a high level of ecological validity, i.e. a relatively high extent to which its results can be generalized (or extended to real-world settings. Due to its specific design, which involved the cooperation of a bestselling author and his publisher, the study approximated the typical conditions in which people read fiction in a remarkably accurate way. Finally, our research has potential practical implications for promoting animal welfare.

  11. Caribbean literary theory: modernist and postmodern

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    A. James Arnold

    1995-01-01

    Full Text Available [First paragraph] The Repeating Mand: The Caribbean and the Postmodern Perspective. ANTONIO BENITEZ-ROJO. Durham NC: Duke University Press, 1992. xi + 303 pp. (Cloth US$ 49.95, Paper US$ 15.95 Myth and History in Caribbean Fiction: Alejo Carpentier, Wilson Harris, and Edouard Glissant. BARBARA J. WEBB. Amherst: University of Massachusetts Press, 1992. x + 185 pp. (Cloth US$ 25.00 Caribbean literature has been overtaken of late by the quarrels that have pitted postmodernists against modernists in Europe and North America for the past twenty years. The modernists, faced with the fragmentation of the region that hard-nosed pragmatists and empiricists could only see as hostile to the emergence of any common culture, had sought in myth and its literary derivatives the collective impulse to transcend the divisions wrought by colonial history. Fifteen years ago I wrote a book that combined in its lead title the terms Modernism and Negritude in an effort to account for the efforts by mid-century Caribbean writers to come to grips with this problem. A decade later I demonstrated that one of the principal Caribbean modernists, Aimé Césaire, late in his career adopted stylistic characteristics that we associate with the postmodern (Arnold 1990. The example of Césaire should not be taken to suggest that we are dealing with some sort of natural evolution of modernism toward the postmodern. In fact the two terms represent competing paradigms that organize concepts and data so differently as to offer quite divergent maps of the literary Caribbean.

  12. Household Scribes and the Production of Literary Manuscripts in Early Modern England

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    Marcy L. North

    2015-03-01

    Full Text Available In early modern English households, literate servants such as tutors, chaplains, stewards, secretaries, and ladies in waiting were well positioned to assist their employers in the assembly and copying of verse miscellanies, anthologies, and other literary manuscripts. Looking at several literary manuscripts, some with known servant contributions and others that suggest the participation of household retainers, the essay explores the likelihood that literate servants often performed scribal tasks above and beyond their formal job descriptions, even serving as scribe for their employers’ hobbies and leisure activities. Although copying was an arduous task, servants appear to have viewed these duties not simply as part of their job but also as gift exchanges, as appeals for promotion or patronage, and as a means by which they might gain access to manuscript literature and literary circles. Studies of early modern letter writing have called attention to many of the copy tasks of literate household servants, but the integral role of literate servants in the collection, copying, and preservation of literary manuscripts deserves much more attention.

  13. The Literary Legacy Inherited by Ankara of the Republican Era: Literary Life and Milieux in Ankara until the Republic Era

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    Necati Tonga

    2014-12-01

    Full Text Available Ankara became one of the most important circles of literary activities after the establishment of the Republic of Turkey in 1923. In this era, the most prevalent factor for this nourishment was that Ankara was chosen as the capital city and Turkey would be governed from Ankara from then on. Besides this fact, before being the capital, Ankara had a rich background in terms of literature. The city had a strong tradition of Divan and Sufi literature in the ruling periods of Seljuks and Ottomans. Many Divan poets and minstrels lived in Ankara throughout history. In those times, in addition to madrasahs, dervish lodges and mosques, there were taverns, inns, mansions, coffeehouses, vineyards and gardens that were used for gatherings where poems were recited and talks about literature took place. Before the establishment of the Republic, in the years between 1919 and 1922, Mustafa Kemal Atatürk proclaimed Ankara as the headquarters of the national movements. This choice brought out a liveliness to Ankara in terms of literature. In this period until the Republic, many places serving as dervish lodges, coffeehouses, restaurants, gardens, taverns, and shops, and newspaper editorials such as Tâceddin Dergâhı (Taceddin’s Lodge, Kuyulu Kahve (Coffee-shop, Merkez Kıraathanesi (Central coffee-shop, Hakimiyet-i Milliye and Yenigün Newspaper Editorial Offices, Anadolu Lokantası (Anadolu Restaurant, Teceddüt Lokantası (Teceddüt Restaurant, Abdullah Efendi Lokantası (Abdullah Efendi Restaurant, Muallimler Birliği (Teachers Union, Şehir Bahçesi (City Garden, Dayko’nun Tütüncü Dükkânı (Dayko’s Tobacco Shop and Efe Haydar’ın Meyhanesi (Efe Haydar’s Tavern were prominent gathering places that flourished in the literary activities of Ankara.

  14. DIAGNOSTIC CRITERIA FOR PROLIFERATIVE THYROID LESIONS IN BONY FISHES

    Science.gov (United States)

    Thyroid proliferative lesions are rather common in bony fishes but disagreement exists in the fish pathology community concerning diagnostic criteria for hyperplastic versus neoplastic lesions. To simplify the diagnosis of proliferative thyroid lesions and to reduce confusion reg...

  15. Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74

    Science.gov (United States)

    Djudjaj, Sonja; Lue, Hongqi; Rong, Song; Papasotiriou, Marios; Klinkhammer, Barbara M.; Zok, Stephanie; Klaener, Ole; Braun, Gerald S.; Lindenmeyer, Maja T.; Cohen, Clemens D.; Bucala, Richard; Tittel, Andre P.; Kurts, Christian; Moeller, Marcus J.; Floege, Juergen; Ostendorf, Tammo

    2016-01-01

    Pathologic proliferation of mesangial and parietal epithelial cells (PECs) is a hallmark of various glomerulonephritides. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that mediates inflammation by engagement of a receptor complex involving the components CD74, CD44, CXCR2, and CXCR4. The proliferative effects of MIF may involve CD74 together with the coreceptor and PEC activation marker CD44. Herein, we analyzed the effects of local glomerular MIF/CD74/CD44 signaling in proliferative glomerulonephritides. MIF, CD74, and CD44 were upregulated in the glomeruli of patients and mice with proliferative glomerulonephritides. During disease, CD74 and CD44 were expressed de novo in PECs and colocalized in both PECs and mesangial cells. Stress stimuli induced MIF secretion from glomerular cells in vitro and in vivo, in particular from podocytes, and MIF stimulation induced proliferation of PECs and mesangial cells via CD74. In murine crescentic GN, Mif-deficient mice were almost completely protected from glomerular injury, the development of cellular crescents, and the activation and proliferation of PECs and mesangial cells, whereas wild-type mice were not. Bone marrow reconstitution studies showed that deficiency of both nonmyeloid and bone marrow–derived Mif reduced glomerular cell proliferation and injury. In contrast to wild-type mice, Cd74-deficient mice also were protected from glomerular injury and ensuing activation and proliferation of PECs and mesangial cells. Our data suggest a novel molecular mechanism and glomerular cell crosstalk by which local upregulation of MIF and its receptor complex CD74/CD44 mediate glomerular injury and pathologic proliferation in GN. PMID:26453615

  16. Proliferative myositis in a patient with AIDS

    Energy Technology Data Exchange (ETDEWEB)

    Wlachovska, B.; Deux, J.F.; Marsault, C.; Le Breton, C. [Department of Radiology, Hopital Tenon, 4 rue de la Chine, 75020, Paris (France); Abraham, B. [Department of Tropical and Infectious Diseases, Hopital Tenon, Paris (France); Sibony, M. [Department of Anatomy, Hopital Tenon, Paris (France)

    2004-04-01

    We report a case of proliferative myositis in the right biceps of a 56-year-old man with acquired immune deficiency syndrome (AIDS). Imaging methods included sonography, computed tomography and magnetic resonance imaging. The diagnosis was made by a core-cut biopsy and fine needle aspiration biopsy with immunohistochemical analysis. The lesion disappeared after 2 months without treatment. It is particularly important to determine whether intramuscular masses arising in patients with AIDS are due to an infectious or malignant process. (orig.)

  17. Proliferative myositis in a patient with AIDS

    International Nuclear Information System (INIS)

    Wlachovska, B.; Deux, J.F.; Marsault, C.; Le Breton, C.; Abraham, B.; Sibony, M.

    2004-01-01

    We report a case of proliferative myositis in the right biceps of a 56-year-old man with acquired immune deficiency syndrome (AIDS). Imaging methods included sonography, computed tomography and magnetic resonance imaging. The diagnosis was made by a core-cut biopsy and fine needle aspiration biopsy with immunohistochemical analysis. The lesion disappeared after 2 months without treatment. It is particularly important to determine whether intramuscular masses arising in patients with AIDS are due to an infectious or malignant process. (orig.)

  18. COMPARISONS BETWEEN THE NON-PROLIFERATIVE AND PROLIFERATIVE THERAPY IN FIBROCYSTIC MASTOSIS.

    Science.gov (United States)

    Carauleanu, A; Socolov, R; Rugina, V; Gabia, O; Carauleanu, Daniela Mihaela; Lupascu, Ivona Anghlcelache; Socolov, Demetra

    2016-01-01

    Fibrocystic mastosis (FCM) is the most frequent benign breast lesion. Most treatments for fibrocystic mastosis are: hormonl, with beneficial results and non-hormonal, with fluctuating results. A number of 210 cases were studied, which were divided into 7 groups. The study lasted for 9 months and it was carried out on the basis of a personal examination sheet. The following were monitored: age groups, mastodynia, reducing breast nodules, a significant reduction in the volume of the mastosic cysts, reducion of the fibrous tissue, medication tolerance. Mastodynia has declined by 90% in the cases treated with Tamoxifen and Danazol, by 70% in the case of Lynestrenol and Bromocriptine, by 50% in the 15 patients who were given Utrogestan. Knowing the advantages and disadvantages of drugs (contraindications, side effects), age category, breast pain reduction, antiproliferative activity, tolerability, relapse allow us to assess the benefit-risk. Even in those circumstances that remained incompletely clarified for objective reasons, related to the inaccurate/incorrect reporting by the patients, there is a significant difference (p < 0.05) between the frequency of relapses following the treatment with Tamoxifen and the other categories of drugs who were administered. Our study shows that in the groups that were administered Logest, Utrogestan and Bromocriptine, only antalgic effects were achieved (disappearance or only decrease of mastodynia) and no anti-proliferative effects were obtained. Basically, hormone treatment should be made based on a histopathological examination.

  19. Antibacterial, antioxidant and cell proliferative properties of Coccinia grandis fruits

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    Prashant Sakharkar

    2017-06-01

    Full Text Available Objective: Little knowledge is available on the antimicrobial and antioxidant properties of Coccina grandis fruits and no study has reported on its cell proliferative property. The aim of this study was to examine the antimicrobial, antioxidant and cell proliferative property of fruits of C. grandis. Material and Methods: Fruits of C. grandis were extracted using water; ethanol and acetone by cold and hot Soxhlet extraction. The antibacterial activities of the extracts were tested against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Pseudomonas aeruginosa using the modified Kirby-Bauer diffusion method and compared against erythromycin. The antioxidant property was determined using Cayman's antioxidant assay; whereas cell proliferation/cytotoxic properties were evaluated using the Cell Titer 96 Aqueous One Solution Cell MTS assay with MDA-MB 321 breast cancer cells. Data were analyzed for correlation and differences using unpaired student's t-test and one-way ANOVA. A p value of Results: Both cold and hot ethanol and acetone extracts of C. grandis fruits showed some degree of bacterial growth inhibition. Acetone extracts exhibited higher antibacterial activity. Both ethanol extracts showed antioxidant property when compared with standard Trolox. In contrary to cytotoxicity, all four extracts showed cell proliferation compared to controls at different concentrations. However, acetone extracts exhibited greater cell proliferation compared to ethanol extracts and cold extracts performed better than the hot extracts. Conclusion: C. grandis fruits exhibited some degree of antimicrobial, antioxidant and cell proliferative properties. Further investigation is warranted to isolate, confirm and characterize phytochemicals that are responsible for the medicinal properties observed.

  20. Standard effective doses for proliferative tumours

    International Nuclear Information System (INIS)

    Jones, L.C.; Hoban, P.

    1999-01-01

    This study was undertaken to investigate the treatment schedules used clinically for highly proliferative tumours, particularly with reference to the effects of fraction size, fraction number and treatment duration. The linear quadratic model (with time component) is used here to compare non-standard treatment regimens (e.g. accelerated and hyperfractionated schedules), currently the focus of randomized trials, with each other and some common 'standard regimens'. To ensure easy interpretation of results, two parameters known as proliferative standard effective dose one (PSED 1 ) and proliferative standard effective dose two (PSED 2 ) have been calculated for each regimen. Graphs of PSED 1 and PSED 2 versus potential doubling time (T p ) have been generated for a range of fractionation regimens which are currently under trial in various randomized studies. From these graphs it can be seen that the highly accelerated schedules (such as CHART) only show advantages for tumours with very short potential doubling times. Calculations for most of the schedules considered showed at least equivalent tumour control expected for the trial schedule compared with the control arm used and these values agree quite well with clinical results. These calculations are in good agreement with clinical results available at present. The greater the PSED 1 or PSED 2 for the schedule considered the greater the tumour control, which can be expected. However, as has been seen with clinical trials, this higher cell kill also results in higher acute effects which have proved too great for some accelerated schedules to continue. (author)

  1. 3,3'-Diindolylmethane, a cruciferous vegetable derived synthetic anti-proliferative compound in thyroid disease

    International Nuclear Information System (INIS)

    Tadi, Kiranmayi; Chang Yushan; Ashok, Badithe T.; Chen, Yuangen; Moscatello, Augustine; Schaefer, Steven D.; Schantz, Stimsom P.; Policastro, Anthony J.; Geliebter, Jan; Tiwari, Raj K.

    2005-01-01

    Considerable epidemiological evidence exists to link thyroid disease with differing patterns of dietary consumption, in particular, cruciferous vegetables. We have been studying the anti-thyroid cancer (TCa) activity of indole-3-carbinol (I3C) found in cruciferous vegetables and its acid catalyzed dimer, 3,3'-diindolylmethane (DIM). There are no studies as yet to elucidate the effect of these compounds on the altered proliferative patterns in goiter or thyroid neoplasia. In this study, we tested the anti-proliferative effects of I3C and DIM on four different thyroid cancer cell lines representative of papillary (B-CPAP and 8505-C) and follicular carcinoma of the thyroid (CGTH-W-1 and ML-1), and primary human goiter cells. Cell survival and IC 50 values for I3C and DIM were calculated by the XTT assay and cell cycle distribution analysis was done by flow cytometry. DIM was found to be a better anti-proliferative agent than I3C in both papillary and follicular TCa resulting in a greater cytotoxic effect at a concentration over three fold lower than predicted by the molar ratio of DIM and I3C. The anti-proliferative activity of DIM in follicular TCa was mediated by a G1 arrest followed by induction of apoptosis. DIM also inhibited the growth of primary goiter cells by 70% compared to untreated controls. Contrary to traditional belief that cruciferous vegetables are 'goitrogenic,' DIM has anti-proliferative effects in glandular thyroid proliferative disease. Our preclinical studies provide a strong rationale for the clinical exploration of DIM as an adjuvant to surgery in thyroid proliferative disease

  2. INFORMATION AND COMMUNICATION TECHNOLOGY IN ORGANIZATION OF EXTRACURRICULAR WORK WITH GIFTED STUDENTS IN THE SYSTEM OF THE LITERARY EDUCATION

    Directory of Open Access Journals (Sweden)

    Ольга Петрович

    2014-10-01

    Full Text Available The article deals with the issue of features of the use of information and communication technology in organizing extra-curricular activities with the literary gifted students. Main attention is drawn on the effective forms and methods of information and communication technology for the successful conduction of extracurricular activities with gifted high school students in literary education system, in particular such as: web quests, QR-codes, QR-quests, Google Groups, multimedia presentations, blogging, virtual tours, use of interactive whiteboards, educational forums, databases educational resources, virtual libraries, creating the electronic portfolio, media library of educational material, comics, doodles, clouds of words etc.

  3. Horslips in Irish Musical and Literary Culture

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    John L. Murphy

    2008-03-01

    Full Text Available This essay examines the literary impact of a musical electric-folk band. Horslips combined psychedelic, and hard rock with Irish traditional motifs and Celtic narrative themes. Spanning the decade from 1970 to 1980, their success and decline followed the trajectory of the countercultural movement, which came late to Ireland. The band’s revival of mythic characters and historical events drawn from the Irish past attracted fans from all over the island, as well as the diaspora; many young people gained an appreciation of their Irish heritage for the first time, as Horslips became the first electric folk-rock band to fuse disparate genres, and to succeed as an Irish-based independent collective who controlled the graphics, marketing, distribution, and promotion of their music. They inspired the likes of U2 and the Irish punk and new-wave rock musicians who followed them, and without the pioneering efforts of Horslips, Irish music and culture today may never have reached its current success, three decades later.

  4. Stranger than fiction: literary and clinical amnesia.

    Science.gov (United States)

    Dieguez, Sebastian; Annoni, Jean-Marie

    2013-01-01

    This chapter broadly covers literary uses of amnesia and memory disorders. Amnesia in fiction offers authors an efficient and dramatic device to tackle themes such as identity, personal liberty, or guilt. We argue against the common complaint that fictional amnesia is scientifically inaccurate, pointing out that the goals of literature are different from those of science, that amnesia is still poorly understood, and that real-life cases can sometimes be stranger than fiction. The chapter provides examples from the neuropsychological literature, media reports, mythology, historical cases, detective stories, war stories, theatrical plays, and other genres. Special attention is given to retrograde and dissociative amnesia, as these are the most frequent types of amnesia portrayed in fiction, while other types of memory disorders are more shortly treated. We argue that the predominance of disorders affecting autobiographical memory in fiction is in itself a revealing fact about the mechanisms of human memory, illustrating how fictional treatments of pathology can inform back neurological and psychological research. Copyright © 2013 S. Karger AG, Basel.

  5. The magic of Rudaki's thought and literary language

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    M.S Basiri

    2009-06-01

    Full Text Available This article, at first, discuses the fact that language is the most important means of human being to reach the fact and beauty. Language is a means of logical thinking rather than a way of communication. However, literary language in Rudaki's poetry has the best capacity to identify and reveal mental concepts through using aesthetics. The main question of this article is how Rudaki connected language to thought and what is his artistic creation? For this reason the researcher, after presenting and considering evidences, proves that Rudaki has used all characteristics of language and principals of creative language to connect literary language and thought together. The most prominent elements of Rudaki's thought and literary language are: using the most proper words in collocation, distinguishing the relationship of cause and effect and existence through literary language, asserting artistic fact, using imagination and principles of association of meanings, and entering poetical experience in language dominion (domain.

  6. Sherlock Holmes: From literary character to pop culture symbol

    OpenAIRE

    HULCOVÁ, Anna

    2013-01-01

    The bachelor thesis Sherlock Holmes: From literary character to pop culture symbol deals with the collection of sixty detective stories by Arthur Conan Doyle, the canon. The aim of the thesis is to highlight the aspects that contributed to the popularity of Sherlock Holmes and the series as such. The character of Sherlock Holmes became one of the most adapted literary characters, which is reflected in many areas of popular culture. Special attention is paid to the recent adaptations presentin...

  7. A selection of Slovenian literary heroes for the preschool period

    OpenAIRE

    Dolinar, Ana

    2014-01-01

    In preschools, Slovenian literary heroes are being displaced by foreign fantastic heroes that impress children via cartoons, magazines and video games. Slovenian heroes are an important part of our culture and can act as companions of sorts within citizenship education of youngsters. This thesis should serve as a promotion of Slovenian literary heroes for children of all ages, beginning with the preschool period. The thesis defines the selection criterion of characters; it introduces their st...

  8. Proliferative glomerulonephritis and primary antiphospholipid syndrome

    International Nuclear Information System (INIS)

    Abdalla, H. Abdalla; Kfoury, Hala K.; Al-Khader, Abdulla A.; Al-Suleiman, M.

    2006-01-01

    Little is known regarding the association of primary antiphospholipid syndrome (APLS) and proliferative glomerulonephiritis (GN). We describe a biopsy-documented case with primary APLS and proliferative (GN) with no evidence of thrombotic microangiopathy (TMA), and in the absence of other manifestations of systematic lupus erythematosus (SLE). She presented initially with left popliteal deep venous thrombosis and nephrotic syndrome. Her first pregnancy at the age of 26 years resulted in the intra-uterine fetal death at term. Two subsequent pregnancies ended up with miscarriages at 3 and 4 months of gestation. Urinalysis revealed glomerular red blood cells of 1.0000.000/ml and granular cast; proteinuria of 13.4grams/24 hours, which was non-selective; hemoglobin 12 gm/dl, normal white blood cell and platelets; serum albumin 2.6gm/dl; anti-nuclear antibody (ANA) and anti DNA were negative and complement levels normal. Lupus anticoagulant was positive leading to a diagnosis of primary APLS. The biopsy findings were consistent with membranoproliferative GN. She continued to have steroid-resistant proteinuria, but stable renal function after a 12-year follow up period. She had 2 pregnancies during this period and was delivered at term using caesarian section. She received heparin during the pregnancies. Later she developed hypertension easily controlled by atenolol. This case provides evidence that primary APLS can be associated with proliferative GN due to immune deposits and not only TMA as previously reported, and in the complete absence of SLE. Performing more renal biopsies in this group of patients may disclose a greater prevalence of proleferative GN and may help in devising a rationale for treatment. (author)

  9. Amniocar as a proliferative medium for mesenchymal cells

    Directory of Open Access Journals (Sweden)

    V. V. Chestkov

    2014-01-01

    Full Text Available Objectives. To develop the Amniocar nutrient medium that contains fetal calf serum (FCS and growth factors cocktail for mass cultivation of human fibroblasts. To study proliferative activity of the medium on cultures of HUVEC cells of mesenchymal origin and mesenchymal stromal cells, as well as on cell culture of human amniotic fluid.Materials and methods. Determination of the rate of accumulation of the cellular mass and cell morphology in the course of cultivation of cells of various histogenesis in the Amniocar medium and nutrient medium that contains 10 % of FCS.Results. It has been demonstrated that the Amniocar medium is prevalent as compared to the standard DMEM medium with 10 % of FCS by 2 to 5 times for cultivation of skin fibroblasts, HUVEC, and mesenchymal stem cells. The Amniocar medium increased the quantity of endothelial cells that enter mitosis and maintained the culture of HUVEC cells with prolonged passaging in vitro. Clonal cultivation of human amniotic fluid cells in the Amniocar medium secured development of colonies of both fibroblast and epithelial type.Conclusions. Proliferative Amniocar medium is efficient for mass cultivation of various cells of mesenchymal origin and can be used for diagnostic purposes in medical genetics, oncology, etc.

  10. Toward a Definition of International Literary Journalism

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    John S. Bak

    2017-12-01

    Palavras-chave: Jornalismo. Jornalismo Literário internacional. Reportagem. Verdade versus fato. Imprensa democrática. A finales del siglo XIX, en diversos países se estaba desarrollando en sus tradiciones periodísticas un fenómeno similar a lo que hoy conocemos como periodismo literario o reportaje literario. Sin embargo, durante la mayor parte del siglo XX, y en particular después de la Primera Guerra Mundial, esa tradición fue eclipsada e incluso marginada por la percepción general entre los estados democráticos de que el periodismo debía ser “objetivo,” como en la tradición americana, o polémico, como en la europea. Sin embargo, el periodismo literario sobrevivió y con el tiempo incluso prosperó. El cómo y el por qué es un caso único de cada nación. El propósito de este ensayo, que se trata de la introducción revisada y actualizada publicada en el libro Literary Journalism a través del Globo: periodística de tradiciones y transnacionales influencias, coeditado con Bill Reynolds (Amherst and Boston: University of Massachusetts Press, 2011, evaluar hasta qué punto el periodismo literario durante el siglo pasado ha influido reportando lo que ocurría en diversos países—algunos de los cuales han conocido recientemente la democracia, mientras que otros están bajo el control total o parcial del estado—y cómo ha podido dar forma a la heurística periodística y la estética literaria en el siglo XXI.

  11. Cetuximab-Associated Crescentic Diffuse Proliferative Glomerulonephritis

    Directory of Open Access Journals (Sweden)

    Sukesh Manthri

    2017-01-01

    Full Text Available Cetuximab-induced nephrotoxicity is very rare, occurring in less than 1% of colorectal cancer patients and not defined in other populations. We report a rare case of crescentic diffuse proliferative glomerulonephritis (GN that developed in close temporal association with cetuximab treatment. A 65-year-old female recently completed chemotherapy with cetuximab treatment for moderately differentiated oral squamous cell carcinoma. She was admitted with acute renal failure and nephrotic-range proteinuria. Laboratory data showed serum creatinine of 6.6 mg/dl and urinalysis showed proteinuria, moderate hemoglobinuria, hyaline casts (41/LPF, WBC (28/HPF, and RBC (81/HPF. Serologic studies were negative for ANA, anti-GBM, ANCA, hepatitis B, and hepatitis C. Serum C3 and C4 level were normal. Renal biopsy showed crescentic diffuse proliferative GN with focal features of thrombotic microangiopathy. Patient was started on cyclophosphamide and steroids. Her renal function did not improve on day 8 and she was started on hemodialysis. Previous reports suggest that EGFR-targeting medications can possibly trigger or exacerbate an IgA-mediated glomerular process leading to renal failure. This case suggests that cetuximab therapy may have triggered or exacerbated a severe glomerular injury with an unfavorable outcome. Treating physicians should maintain a high degree of caution and monitor renal function in patients on EGFR inhibitors.

  12. Correlation of proliferative and clonogenic tumor cells in multiple myeloma

    International Nuclear Information System (INIS)

    Karp, J.E.; Burke, P.J.; Saylor, P.L.; Humphrey, R.L.

    1984-01-01

    To expand on the findings from previous clinical trials that the growth of residual tumor is increased at a predictable time following initial drug administration, malignant plasma cells from bone marrows of patients with multiple myeloma (MM) were examined for changes in proliferation and clonogenicity induced in vivo by cyclophosphamide and in vitro by drug-induced humoral stimulatory activity. Peak plasma cell [ 3 H]thymidine labeling index (LI) occurred predictably following drug and paralleled changes in agar colony formation by marrow cells obtained during therapy. Colony-forming capacity of pretreatment MM marrow populations was enhanced when those cells were cultured with humoral stimulatory activity, similar to the increased colony formation detected in Day 9 postcyclophosphamide marrows at the time of peak plasma cell LI. To further define a relationship between proliferative plasma cells and colony-forming tumor cells, MM marrows were fractionated by sedimentation on an isokinetic gradient. Enrichment of a proliferative tumor cell cohort was achieved, evidenced by [ 3 H]thymidine LI. Colony-forming cells were also enriched by isokinetic gradient sedimentation, and agar colony formation by MM marrow cell fractions correlated with the kinetic characteristics of the isolated subpopulations. These studies of whole and fractionated human MM marrow cell populations suggest that the kinetically active cells which are induced to proliferate in vivo and in vitro are closely related to the clonogenic tumor cells which produce colonies in agar and which, like those cells measured by [ 3 H]thymidine LI, respond to growth stimulation by drug-induced humoral stimulatory activity

  13. A Predictive Model for Estimation Risk of Proliferative Lupus Nephritis

    Directory of Open Access Journals (Sweden)

    Dong-Ni Chen

    2018-01-01

    Conclusion: This study developed and validated a model including demographic and clinical indices to evaluate the probability of presenting proliferative LN to guide therapeutic decisions and outcomes.

  14. Body linear traits for identifying prolific goats

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    Avijit Haldar

    2014-12-01

    Full Text Available Aim: The present study was conducted on prolific goat breed to identify body linear type traits that might be associated with prolificacy trait in goats. Materials and Methods: Two-stage stratified random sample survey based data were collected from 1427 non-pregnant goats with the history of single, twin and triplet litter sizes (LZ between January 2008 to February 2011 for 3 years in 68 villages located in East and North East India. Data on sixteen body linear traits were analyzed using logistic regression model to do the step-wise selection for identifying the body linear traits that could determine LZ. An average value for each identified body linear trait was determined for classifying the goats into three categories: Goats having the history of single LZ, goats having the history of twin LZ and goats having the history of triplet LZ. Results: The LZ proportions for single, twin and triplet, were 29.50, 59.14 and 11.36%, respectively, with the prolificacy rate of 181.85% in Indian Black Bengal goats. A total of eight body linear traits that could determine LZ in prolific goats were identified. Heart girth (HG measurement (>60.90 cm, paunch girth (PG (>70.22 cm, wither height (WH (>49.75 cm, neck length (>21.45 cm, ear length (>12.80 cm and distance between trochanter major (DTM bones (>12.28 cm, pelvic triangle area (PTA (>572.25 cm2 and clearance at udder (CU (>23.16 cm showed an increase likelihood of multiple LZ when compared to single LZ. Further, HG measurement (>62.29 cm, WH (>50.54 cm, PG (>71.85 cm and ear length (>13.00 cm, neck length (>22.01 cm, PTA (>589.64 cm2, CU (>23.20 cm and DTM bones (>12.47 cm were associated with increased likelihood of triplet LZ, when compared with that of twin LZ. Conclusion: HG measurement was the best discriminating factor, while PG, neck length, DTM bones, CU, PTA, WH and ear length measurements were other important factors that could be used for identifying prolific goats to achieve economic

  15. Literature and Language Teaching: Exploring Literary Texts with the Language Learner and Re-Creating Literature in the ESL Classroom.

    Science.gov (United States)

    Lazar, Gillian; Heath, Shirley Brice

    1996-01-01

    Two educators discuss the role literature plays in the English as a Second Language (ESL) classroom. One emphasizes that literary texts are a source for classroom activities that can motivate learners. The other points out that the English writings of ESL students about their travels and friends published in newsletters and journals generate…

  16. Moroccan Mothers' Involvement in Dialogic Literary Gatherings in a Catalan Urban Primary School: Increasing Educative Interactions and Improving Learning

    Science.gov (United States)

    de Botton, Lena; Girbés, Sandra; Ruiz, Laura; Tellado, Itxaso

    2014-01-01

    This article analyses a case study on Moroccan mothers' involvement in the Dialogic Literary Gathering (DLG) in an urban primary school in Catalonia (Spain). DLG is a dialogic learning environment that improves reading skills and communicative abilities and promotes school-community links. This activity has been identified in previous European…

  17. The Missing Hybridity: ‘Envisioning’ Ukrainian Literary Space

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    Marco Puleri

    2015-05-01

    Full Text Available In this paper, the author focuses on the question concerning the complex positioning of the Russophone literary phenomenon in the Ukrainian post-Soviet literary canon. Analysing the conceptualization of the hybrid cultural elements in the post-Soviet cultural area, it is possible to observe the rise of a contrast between the cultural ‘exclusivist’ and ‘inclusivist’ attitudes in the Ukrainian literary debate. It is the product of the renewed social and political clash between the Ukrainian and Russian ‘national systems’. The ideologization of the ethnolinguistic factor in the Post-Soviet area gives birth to competing ideologies, which draw new ‘imagined borders’ in the Ukrainian literary space. It is the result of the polarization of the respective national historical narratives, misused by the current political discourses, to paralyse the dialogical perspectives in the process of cultural confrontation. Listening to the ‘voices’ of contemporary cultural actors, it will be possible to draw different images in order to envision the Ukrainian literary space.

  18. Picture Books Featuring Literary Characters with Special Needs

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    Batič Janja

    2013-11-01

    Full Text Available This paper introduces a selection of picture books that feature a person with special needs as the main literary character. The selection of the books to be showcased was based on three crucial aspects: the form of the (picture book, as we wanted to underline the visual importance of a literary character with special needs; the age limit of the readers the books are intended for (preschool and early primary school; and undisputable quality of the literary and artistic components of the picture books. The picture books we have selected based on the above criteria are Veveriček posebne sorte by Svetlana Makarovič and Marjan Manček, Mrožek dobi očala by Peter Svetina and Mojca Osojnik, and Zakaj je babica jezna by Lela B. Njatin and Alenka Sottler. Picture books about literary characters with special needs can help highly sensitive children accepting people that are different, while children with special needs can build a better self-image based on such books. Quality literary books which foster a positive attitude towards a character with special needs promote tolerance and can thus play an important role in the early childhood, with regard to awareness of an inclusive society.

  19. 18F-FLT Positron Emission Tomography/Computed Tomography Imaging in Pancreatic Cancer: Determination of Tumor Proliferative Activity and Comparison with Glycolytic Activity as Measured by 18F-FDG Positron Emission Tomography/Computed Tomography Imaging

    Directory of Open Access Journals (Sweden)

    Senait Aknaw Debebe

    2016-02-01

    Full Text Available Objective: This phase-I imaging study examined the imaging characteristic of 3’-deoxy-3’-(18F-fluorothymidine (18F-FLT positron emission tomography (PET in patients with pancreatic cancer and comparisons were made with (18F-fluorodeoxyglucose (18F-FDG. The ultimate aim was to develop a molecular imaging tool that could better define the biologic characteristics of pancreas cancer, and to identify the patients who could potentially benefit from surgical resection who were deemed inoperable by conventional means of staging. Methods: Six patients with newly diagnosed pancreatic cancer underwent a combined FLT and FDG computed tomography (CT PET/CT imaging protocol. The FLT PET/CT scan was performed within 1 week of FDG PET/CT imaging. Tumor uptake of a tracer was determined and compared using various techniques; statistical thresholding (z score=2.5, and fixed standardized uptake value (SUV thresholds of 1.4 and 2.5, and applying a threshold of 40% of maximum SUV (SUVmax and mean SUV (SUVmean. The correlation of functional tumor volumes (FTV between 18F-FDG and 18F-FLT was assessed using linear regression analysis. Results: It was found that there is a correlation in FTV due to metabolic and proliferation activity when using a threshold of SUV 2.5 for FDG and 1.4 for FLT (r=0.698, p=ns, but a better correlation was obtained when using SUV of 2.5 for both tracers (r=0.698, p=ns. The z score thresholding (z=2.5 method showed lower correlation between the FTVs (r=0.698, p=ns of FDG and FLT PET. Conclusion: Different tumor segmentation techniques yielded varying degrees of correlation in FTV between FLT and FDGPET images. FLT imaging may have a different meaning in determining tumor biology and prognosis.

  20. The proliferative human monocyte subpopulation contains osteoclast precursors

    Science.gov (United States)

    Lari, Roya; Kitchener, Peter D; Hamilton, John A

    2009-01-01

    Introduction Immediate precursors of bone-resorbing osteoclasts are cells of the monocyte/macrophage lineage. Particularly during clinical conditions showing bone loss, it would appear that osteoclast precursors are mobilized from bone marrow into the circulation prior to entering tissues undergoing such loss. The observed heterogeneity of peripheral blood monocytes has led to the notion that different monocyte subpopulations may have special or restricted functions, including as osteoclast precursors. Methods Human peripheral blood monocytes were sorted based upon their degree of proliferation and cultured in macrophage colony-stimulating factor (M-CSF or CSF-1) and receptor activator of nuclear factor-kappa-B ligand (RANKL). Results The monocyte subpopulation that is capable of proliferation gave rise to significantly more multinucleated, bone-resorbing osteoclasts than the bulk of the monocytes. Conclusions Human peripheral blood osteoclast precursors reside in the proliferative monocyte subpopulation. PMID:19222861

  1. Music in Serbian literary magazine and Yugoslav ideology

    Directory of Open Access Journals (Sweden)

    Vasić Aleksandar N.

    2004-01-01

    Full Text Available It is worth noting that the important journal of the history of Serbian literature and music, the Serbian Literary Magazine (1901 - 1914, 1920 1941, became more Yugoslav-oriented within a relatively short period following its inception. From its early beginning to 1906, the Magazine’s musical critics did not actively express its Yugoslav ideology. But from 1907 there was an increase of interest in both the music and the musicians from Croatia and Slovenia. In 1911 the Croatian Opera spent almost two weeks in Belgrade performing; the composer and musicologist, Miloje Milojević began to develop the idea of union with Slavs from the South in a critical analysis he rendered of their performance. Until the end of the first/old series, SLM highlighted a noticeable number of texts about Croatians and Slovenians: critical reviews of Croatian musical books, concerts of Slovenian artists in Belgrade, score editions of Slovenian music performances of instrument soloists from Zagreb in Belgrade - as well as notes about the musical work of Croatian Academy (Yugoslav Academy of Sciences and Arts, Zagreb. Echoes of rare tours of Serbian musicians in South Slavs cultural centers did not go unheard, either. In the older series of the journal, lasting and two-fold relations had already begun to lean towards Yugoslav ideology. From one side, even before World War I, Yugoslav ideology in the Magazine was accepted as a program objective of Serbian political and cultural elite. On the other, the journal does not appear to have negotiated any of its aesthetic criterion when estimating musical events that came from Zagreb and Ljubljana to Belgrade - at least not "in the name of Yugoslav ideology". In later series of SLM, the Yugoslav platform was being represented as official ideological statehood of newly created Kingdoms of Serbs, Croats and Slovenians (1918, i.e., the Kingdom of Yugoslavia (1929. At that time, the Magazine had occasional literary cooperation from

  2. Avaliação da Atividade Proliferativa no Epitélio Mamário Adjacente a Fibroadenoma em Mulheres Tratadas com Tamoxifeno Evaluation of Proliferative Activity in the Mammary Epithelium Adjacent to Fibroadenoma in Women Treated with Tamoxifen

    Directory of Open Access Journals (Sweden)

    Juarez Antônio de Sousa

    2000-08-01

    Full Text Available Objetivo: estudar a atividade proliferativa do epitélio mamário normal adjacente a fibroadenoma em mulheres na fase lútea do ciclo menstrual, tratadas com tamoxifeno. Pacientes e Métodos: estudou-se por técnica imuno-histoquímica, com o uso do anticorpo monoclonal MIB-1, a atividade proliferativa no epitélio mamário adjacente a fibroadenoma. O estudo foi randomizado e duplo-cego. As 44 mulheres com fibroadenoma foram divididas em 3 grupos: A (n = 16; placebo, B (n = 15; tamoxifeno, 10 mg e C (n = 13; tamoxifeno, 20 mg. O tamoxifeno foi utilizado por 22 dias, a partir do 2º dia do ciclo menstrual, e a biópsia realizada no 23º dia. Resultados: a porcentagem média de núcleos corados por 1000 células no grupo A foi 9,2, no grupo B, 4,5, e no grupo C, 3,2. O teste de Fisher revelou que o tamoxifeno reduziu de forma significante a imunoexpressão do MIB-1 nas doses de 10 e 20 mg em comparação com o grupo placebo (pPurpose: to study the monoclonal antibody MIB-1 in the normal breast epithelium adjacent to a fibroadenoma in women in the luteal phase of the menstrual cycle treated with tamoxifen. Patients and methods: the proliferative activity of the mammary epithelium adjacent to the fibroadenoma was studied by immunohistochemistry based on immunoexpression of the monoclonal antibody MIB-1. The study was randomized and double blind and was conducted on 44 women with fibroadenomas, divided into 3 groups: A (n = 16; placebo, B (n = 15; tamoxifen, 10 mg, and C (n = 13; tamoxifen, 20 mg. Tamoxifen was administered for 22 days starting on the 2nd day of the menstrual cycle and a biopsy was taken on the 23rd day. Results: the mean percentage of stained nuclei per 1000 cells was 9.2 in group A, 4.5 in group B, and 3.2 in group C. Fisher's test revealed that tamoxifen significantly reduced the immunoexpression of MIB-1 at the doses of 10 and 20 mg compared to the placebo group (p<0.0001, with no significant differences between doses in terms of

  3. Another Look at Literary Tazkares (A discussion about the typology of literary tazkares and proposing a model for classifying them

    Directory of Open Access Journals (Sweden)

    Saeed Shafieiun

    2014-12-01

    Full Text Available Abstract Tazkares (anthologies, besides being one of the most basic research sources in literary sciences and being among original historical cultural sources, have generally artistic values due to their literary content and skill of their authors. Moreover, since they are sequential sources and under the influence of previous works, they also follow explicit and implicit criteria and patterns which sometimes promote them even to the level of a genre. Finding structural criteria and generic patterns of Tazkares is not an easy task because the nature of literary Tazkares is to some extent non-literary and overlaps with history and other human sciences and always wants to return to its main non-literary origins. On the other hand, since poetry and literature have been super-media in the classic world and consequently various groups of people in different periods liked them, an enormous fair of them has come into existence throughout time which has had different color and description for its customers and visitors. This matter creates many problems in the so-called literary decadence period. Due to this, generic criteria of Tazkares either remained unknown or were forgotten after the appearance of non-poets. At this point, the researcher faces contradictions repeatedly because he cannot eliminate such instances, on the one hand, and cannot gain theoretical coherence by considering them, on the other. Thus, the best possible solution is to consider separate validity for each research example and, indeed, consider prototypical and standard examples as the base of research and evaluate weaker examples as indication or extension of the main issue.  Assuming that constituents of a genre, from the most trivial and secondary to the main ones, can be studied regarding form, content and presentation, literary Tazkares can be explored as following: regarding the form, elements such as order and organization, volume, independence, literary aspect and shape

  4. The critic as transvestite: the parody nature of literary criticism

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    David Pruneda Sentíes

    2016-09-01

    Full Text Available This paper explores a path in the analysis of literary criticism as an object of study. In order to convey this, this essay attempts to define literary criticism as a genre that parodies the literary text it aspires to examine. Mikhail Bakhtin’s analysis of the novelistic discourse is useful to establish a connection between parody and criticism. Although Bakhtin discusses the novel, I ascertain that his arguments may be applied to the description of criticism as a parodic-travestying genre. Secondly, this paper discusses Linda Hutcheon’s work, which states that parody is a repetition of the original text. According to Hutcheon, this repetition implies a critical distance with the parodied text, which marks difference rather than similarity.

  5. [Eugenics, an element of the literary plots of dystopia].

    Science.gov (United States)

    Baum, Ewa; Musielak, Michał

    2007-01-01

    The work presents the ideas and assumptions of eugenics, a social philosophy established in 1883 by Francis Galton, which affected the social policies of numerous European countries in the first half of the 20th century. The work shows the effect of eugenics on the literary standards of European prose in the previous century. Two outstanding dystopian novels of the 20th century, The Brave New World by Aldous Huxley and 1984 by George Orwell, situate eugenics as a permanent element of the literary plot of dystopia. Apart from the typical features of this type of novel, for example: personal narration with a trace of irony, a totalitarian state and Newspeak, eugenics is an important element of the literary plot with is aim to exclude and marginalise certain social groups. Eugenics is also one of the main social ideas criticised by both the writers.

  6. Kirjanduslikest kontaktidest läbi raudse eesriide / Literary contacts through the iron curtain

    Directory of Open Access Journals (Sweden)

    Marin Laak

    2016-09-01

    Full Text Available The article deals with the relationship between the literature of the Estonian diaspora in the West and Soviet Estonia during the 1960s, and explores the possibility, from the literary historiographical perspective, of integrating the two bodies of Estonian literature. Near the end of The Second World War close to 70,000 Estonians fled their homeland, fearing Soviet repression; among them were numerous members of the academic and artistic intelligentsia as well as eminent poets and writers. By the late 1940s national organizations, publications and other activities were already well underway in the displaced persons camps. During the 1950s, Estonian exiles who settled in Sweden, Canada, United States, and elsewhere in the West quickly formed national cultural centres, publishing houses and numerous organizations that helped maintain their national and cultural identity. The centre of literary activity in the West was Sweden, which most Estonian writers had chosen as their new home. The Estonian Writers’s Co-operative publishing house, established in Lund in 1950, started the mail-order distribution of Estonian literature throughout the world; elsewhere, the publisher Orto operated in Toronto. While no propaganda-free literature or literature of any artistic merit was published in the 1940s and 1950s in Estonia during the Soviet occupation, exile literature flourished. Then, the Khrushchev Thaw brought about changes to Soviet society in the late 1950s. As their world became more free, a new generation of talented young poets emerged who generated innovations in poetry and modernized literature. This article maps literary contacts between the Estonian homeland and her exiles, and, using archival material, focuses on personal contacts among the literati during the 1960s. Literary historiography began investigating the possibility of treating Estonian literature in the homeland and in the West as one body of literature, when, after a 45-year

  7. Post-digital Books and Disruptive Literary Machines

    DEFF Research Database (Denmark)

    Pold, Søren Bro; Andersen, Christian Ulrik

    The e-book has been launched several times during the last decades and the book’s demise has often been predicted. Furthermore networked and electronic literature has already established a long history. However, currently we witness several interesting artistic and literary experiments exploring...... to sketch out how contemporary literary technologies is integral to develop and reflect critically on post- or semio-capitalism, and furthermore we will discuss how literature functions in a post-industrial software culture such as the one presented by Apple, Amazon and Google....

  8. Features of Aestheticism in Literary Heritage of Mikhail Kuzmin

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    Elena Kolmykova

    2015-08-01

    Full Text Available The article deals with the main principles of aestheticism reflected in the literary works of Mikhail Kuzmin, the author of well-known lines: “Широки и спокойны струи, Как судоходный Дунай!” The sources of M. Kuzmin’s aestheticism, such as ideas of Pre-Raphaelites, French symbolists, English aesthetes are under investigation. It is stated that literary heritage of Oscar Wilde greatly influenced M. Kuzmin’s critical works.

  9. Dysregulation of T lymphocyte proliferative responses in autoimmunity.

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    Sydney K Elizer

    Full Text Available T cells are critically dependent on cellular proliferation in order to carry out their effector functions. Autoimmune strains are commonly thought to have uncontrolled T cell proliferation; however, in the murine model of autoimmune diabetes, hypo-proliferation of T cells leading to defective AICD was previously uncovered. We now determine whether lupus prone murine strains are similarly hyporesponsive. Upon extensive characterization of T lymphocyte activation, we have observed a common feature of CD4 T cell activation shared among three autoimmune strains-NOD, MRL, and NZBxNZW F1s. When stimulated with a polyclonal mitogen, CD4 T cells demonstrate arrested cell division and diminished dose responsiveness as compared to the non-autoimmune strain C57BL/6, a phenotype we further traced to a reliance on B cell mediated costimulation, which underscores the success of B cell directed immune therapies in preventing T cell mediated tissue injury. In turn, the diminished proliferative capacity of these CD4 T cells lead to a decreased, but activation appropriate, susceptibility to activation induced cell death. A similar decrement in stimulation response was observed in the CD8 compartment of NOD mice; NOD CD8 T cells were distinguished from lupus prone strains by a diminished dose-responsiveness to anti-CD3 mediated stimulation. This distinction may explain the differential pathogenetic pathways activated in diabetes and lupus prone murine strains.

  10. Autologous proliferative therapies in recalcitrant lateral epicondylitis.

    Science.gov (United States)

    Tetschke, Elisa; Rudolf, Margit; Lohmann, Christoph H; Stärke, Christian

    2015-09-01

    This study investigates the clinical effects of autologous conditioned plasma (ACP) injections and low-level laser application as therapy options for chronic lateral epicondylitis. A total of 52 patients with chronic lateral epicondylitis were evaluated in this study; 26 of these patients received three ACP injections and the control group, with 26 patients, received 12 laser applications, with standardized physical therapy for all patients afterward. Control examinations took place before treatment, after 2 and 6 mos, and in the 1 yr final follow-up. The control examination included the visual analog scale for pain and Disabilities of the Arm, Shoulder and Hand outcome measure scores. The analysis at final follow-up after 1 yr showed that both treatment options resulted in successful therapy outcome for the patients. In total, 63.5 % were successfully treated. Successful treatment was defined as more than 30% improvement in the visual analog score and more than 10.2 points in the Disabilities of the Arm, Shoulder and Hand score. Both groups showed a significant improvement in time response. This study demonstrates the beneficial effects of autologous proliferative therapies in the treatment of lateral epicondylitis. The data show that laser application and ACP therapy lead to a clinical improvement in epicondylopathia. Especially the new treatment with ACP can be highlighted as an alternative and as an easy-to-apply therapy option for clinical practice.

  11. Leptin: A proliferative factor for breast cancer?

    International Nuclear Information System (INIS)

    Caldefie-Chezet, F.; Damez, M.; Latour, M. de; Konska, G.; Mishellani, F.; Fusillier, C.; Guerry, M.; Penault-Llorca, F.; Guillot, J.; Vasson, M.-P.

    2005-01-01

    Mammary adipose tissue is an important source of paracrine mitogens and anti-mitogens, including insulin-like growth factor, transforming growth factors, and cytokines (especially, TNFα and IL-1β). Nevertheless, it is also an important source of the adipocytokine, leptin. Recently, leptin was reported to stimulate the proliferation of various cell types (pancreatic β cells, prostate, colorectal, lung, etc.) as a new growth factor. It was also shown to stimulate the proliferation of breast cancer cell lines. In this study, we conducted an immunohistochemical analysis of leptin expression in normal tissue and benign and malignant ductal breast cell, representing the different states of the invasion process. We determined for the first time that leptin is expressed both by ductal breast tumors and by benign lesions as atypical hyperplasia. This suggests that leptin may be taken up or synthesized by all modified ductal breast cells, and may prove a proliferative factor. Moreover, leptin is unexpressed by normal tissue in the healthy breast but is exhibited by the normal tissue in near vicinity of the malignant ductal breast lesions. We also postulated that leptin may be a prognostic or diagnostic factor for ductal breast cancer. These putative hypotheses require further study

  12. Lack of a differential radiation response for proliferative and non-proliferative rat thyroid cells (FRTL-5) in vitro

    International Nuclear Information System (INIS)

    Brosing, J.W.; Giese, W.L.; Mulcahy, R.T.

    1989-01-01

    FRTL-5 rat thyroid epithelial cells maintain normal thyroid function and morphology in vitro, exhibit an absolute requirement for thyroid stimulating hormone (TSH) for proliferation and display radiation dose response characteristics indistinguishable from those of rat thyroid epithelial cells in vivo. In TSH-free medium cells remain in a non-proliferative, yet viable, state for prolonged periods of time and respond to TSH re-stimulation by a return to exponential growth. Flow cytometric analysis using two-step acridine orange (AO) staining revealed an accumulation of cells in the G1 phase of the cell cycle accompanied by a pronounced reduction in red fluorescence (indicative of RNA content) in FRTL-5 cells cultured in the absence of TSH. The response of proliferative and non-proliferative FRTL-5 cells to single dose, split dose and fractionated radiation was compared to determine whether proliferative status was an important response determinant. The response of FRTL-5 cells was not influenced by proliferative status at the time of irradiation. Additionally, dose response was not altered by variable (12 hr-8 days) non-proliferative intervals before or after irradiation. As revealed by split dose experiments, the rate and extent of sublethal damage repair was likewise similar for proliferative and non-proliferative cells. Multifraction experiments employing three fractions separated by 6 hr intervals indicate that non-proliferative FRTL-5 cells completely repair sublethal damage between fractions. These results indicate that the radiation response of FRTL-5 cells is not influenced by the proliferative status of the cells prior to or post-irradiation

  13. “Journeys are Meaningful” (Travelling, Travellers, Literary Periods, Literary Journeys

    Directory of Open Access Journals (Sweden)

    Fried István

    2015-12-01

    Full Text Available If the changes of the “discourse networks” (Aufschreibesysteme from 1800 to 1900 model the relations pertaining to the personality, to the cultural determinedness of technology and personality as well as to their interconnections (Kittler 1995, especially having in view the literary mise en scène, it applies all the more to travelling - setting out on a journey, heading towards a destination, pilgrimage and/or wandering as well as the relationship between transport technology and personality. The changes taking place in “transport” are partly of technological, partly (in close connection with the former indicative of individual and collective claims. The diplomatic, religious, commercial and educational journeys essentially belong to the continuous processes of European centuries; however, the appearance of the railway starts a new era at least to the same extent as the car and the airplane in the twentieth century. The journeys becoming systematic and perhaps most tightly connected to pilgrimages from the Middle Ages on assured the “transfer” of ideas, attitudes and cultural materials in the widest sense; the journeys and personal encounters (of course, taking place, in part, through correspondence of the more cultured layers mainly, are to be highly appreciated from the viewpoint of the history of mentalities and society.

  14. The semiotics of typography in literary texts. A multimodal approach

    DEFF Research Database (Denmark)

    Nørgaard, Nina

    2009-01-01

    to multimodal discourse proposed, for instance, by Kress & Van Leeuwen (2001) and Baldry & Thibault (2006), and, more specifically, the multimodal approach to typography suggested by Van Leeuwen (2005b; 2006), in order to sketch out a methodological framework applicable to the description and analysis...... of the semiotic potential of typography in literary texts....

  15. In praise of the literary eponym--Henry V sign.

    LENUS (Irish Health Repository)

    Shanahan, F

    2013-01-01

    The use of eponyms in medicine is often discouraged. However, the literary eponym should be an exception as it is not linked with many of the difficulties associated with conventional eponyms and offers descriptive brevity and accuracy. Here, we illustrate the point with Henry V sign, which will be familiar to many who have cared for patients in the terminal stage of illness.

  16. Literary Origins of the Term "School Psychologist" Revisited

    Science.gov (United States)

    Fagan, Thomas K.

    2005-01-01

    Previous research on the literary origins of the term "school psychologist" is revisited, and conclusions are revised in light of new evidence. It appears that the origin of the term in the American literature occurred as early as 1898 in an article by Hugo Munsterberg, predating the usage by Wilhelm Stern in 1911. The early references to the…

  17. 92 A Literary Discourse of Nigerian Children's Accretive Songs (Pp ...

    African Journals Online (AJOL)

    Nekky Umera

    Observation in the past ten years or so shows that some systematic studies of the lore as a ... The importance of these kind of songs is the “training of the participants to ... more.... This game song is usually performed with the view to establishing the most ... context; the literary impact of the song and the predicament of the.

  18. Aesthetic Creativity: Insights from Classical Literary Theory on Creative Learning

    Science.gov (United States)

    Hellstrom, Tomas Georg

    2011-01-01

    This paper addresses the subject of textual creativity by drawing on work done in classical literary theory and criticism, specifically new criticism, structuralism and early poststructuralism. The question of how readers and writers engage creatively with the text is closely related to educational concerns, though they are often thought of as…

  19. Identification of literary movements using complex networks to represent texts

    International Nuclear Information System (INIS)

    Amancio, Diego Raphael; Oliveira, Osvaldo N Jr; Fontoura Costa, Luciano da

    2012-01-01

    The use of statistical methods to analyze large databases of text has been useful in unveiling patterns of human behavior and establishing historical links between cultures and languages. In this study, we identified literary movements by treating books published from 1590 to 1922 as complex networks, whose metrics were analyzed with multivariate techniques to generate six clusters of books. The latter correspond to time periods coinciding with relevant literary movements over the last five centuries. The most important factor contributing to the distinctions between different literary styles was the average shortest path length, in particular the asymmetry of its distribution. Furthermore, over time there has emerged a trend toward larger average shortest path lengths, which is correlated with increased syntactic complexity, and a more uniform use of the words reflected in a smaller power-law coefficient for the distribution of word frequency. Changes in literary style were also found to be driven by opposition to earlier writing styles, as revealed by the analysis performed with geometrical concepts. The approaches adopted here are generic and may be extended to analyze a number of features of languages and cultures. (paper)

  20. Literary Translation as a Tool for Critical Language Planning

    Science.gov (United States)

    Mooneeram, Roshni

    2013-01-01

    This paper argues that Dev Virahsawmy, an author who manipulates literary translation for the purposes of linguistic prestige formation and re-negotiation, is a critical language-policy practitioner, as his work fills an important gap in language planning scholarship. A micro-analysis of the translation of a Shakespearean sonnet into Mauritian…

  1. Children's Acquisition of Literary Genre: Science Fiction versus Fantasy.

    Science.gov (United States)

    Shechter, Myriam; Schecter, Sandra R.

    Using ethnographic observations of 30 children in a multicultural inner-city fifth grade class over a period of one year, a study examined the children's classroom interactions with the literary genres of science fiction and fantasy, investigating their sequential acquisition of the constitutive elements of the two genres as well as their…

  2. Promise Okekwe: Rising Star on the Nigerian Literary Horizon ...

    African Journals Online (AJOL)

    ... a young and upcoming talent on the Nigeria literary horizon. Okekwe was first published in 1992. A resilient and dynamic writer, she has continued to produce texts at a pace akin to Buchi Emecheta's. Her works reveal a remarkable understanding of the human mind. She thus aims at a reconstruction of the wider society.

  3. Social Science and Literary Criticism: What is at stake? | Rohrbaugh ...

    African Journals Online (AJOL)

    disciplines are being born that all too often leave specialists isolated from each other. While at some points the various methods complement each other, at others they remain contradictory or mutually exclusive. Two of the newer such methods, literary ...

  4. A Model for Teaching Literary Analysis Using Systemic Functional Grammar

    Science.gov (United States)

    McCrocklin, Shannon; Slater, Tammy

    2017-01-01

    This article introduces an approach that middle-school teachers can follow to help their students carry out linguistic-based literary analyses. As an example, it draws on Systemic Functional Grammar (SFG) to show how J.K. Rowling used language to characterize Hermione as an intelligent female in "Harry Potter and the Deathly Hallows."…

  5. Walking through the Revolution: A Spatial Reading of Literary Echoes

    Science.gov (United States)

    Queiroz, Ana Isabel; Alves, Daniel

    2015-01-01

    This paper presents an embryo of a literary guide on the Carnation Revolution to be explored for educational historical excursions other than leisure and tourism. We propose a historical trail through the centre of Lisbon, city of the Carnation Revolution, called "Walk through the Revolution." The trail aims to reinforce collective…

  6. Exploring the Materiality of Literary Apps for Children

    DEFF Research Database (Denmark)

    Henkel, Ayoe Qvist

    2016-01-01

    Children’s literature is increasingly being realized in app format, with its possibilities of combining text, music, sound effects, stills, animated movies, verbal language, and, not least, interactivity. This digital and medial literary development calls for new analytical approaches to explore...

  7. Classification and Criticism of Nigeria Literary Drama | Iwuchukwu ...

    African Journals Online (AJOL)

    Nigerian drama has gained prominent and permanent position on the world literary map especially with the winning of the Nobel Prize by Wole Soyinka. In spite of this, problems of definition and criticism of Nigerian drama still persists. The Relativist-Evolution controversies on the origin and classification of Nigerian drama ...

  8. Close Reading of Literary Nonfiction: The Three-Column Journal

    Science.gov (United States)

    McConn, Matthew

    2018-01-01

    The Common Core State Standards have placed more emphasis on the close reading of all texts, and have made a point of increasing the use of nonfiction in secondary English classrooms. In this article, the author describes an approach for implementing close reading of literary nonfiction. The approach comes from a small-scale classroom-based…

  9. Love of poetry and literary creation in Turgenev's 'First love'

    NARCIS (Netherlands)

    de Haard, E.

    2008-01-01

    This article discusses poetic insertions and literary references in Turgenev's 'First Love' (1860). Dependent on variable temporal and evaluative points of view, they function as means of characterization, as indices of a mentality of the past (the Romantic 1830s), and as allusions and potential

  10. Implication of Copyright Provisions for Literary Works in Films and ...

    African Journals Online (AJOL)

    The emphasis of copyright is on original literary works, films, sound recordings and others. The focus of this paper is to discuss the various provisions of the copyright law as they affect films, video and by extension video CD. The study examines the various interpretations of the provisions of the copyright law as they affect ...

  11. Wikipedia in Promoting Science Literary Skills in Primary Schools

    Science.gov (United States)

    Menon, Sunitha; Alias, Norlidah; DeWitt, Dorothy

    2014-01-01

    In learning Science, online environments allowing for user generated content are becoming increasingly important since they offer possibilities for learners to elaborate on assignments and projects. This study investigates how Wikipedia can serve as a means for enhancing science literary skills when students are encouraged to participate in…

  12. Functional aesthetics of literary theory and the conflict of ...

    African Journals Online (AJOL)

    Because of this, it is generally assumed that the more you grow in your capacity to understand theory, the more you will be able to think broadly and deeply about human experience and the world of ideas, to appreciate this density and shades of meaning available in literary works. But there are so many theories which ...

  13. Andalusī Vestiges in the Ethiopian Islamic Literary Tradition

    DEFF Research Database (Denmark)

    Hernandez-Lopez, Adday

    2017-01-01

    This contribution constitutes my first approach to the material that has been gathered to date within the research project “Islam in the Horn of Africa: A Comparative Literary Approach” in which I am currently engaged. The analysis of the manuscripts comprising the corpus has put several traces o...

  14. Using "The Giving Tree" To Teach Literary Criticism.

    Science.gov (United States)

    Remler, Nancy Lawson

    2000-01-01

    Argues that introducing students to literary criticism while introducing them to literature boosts their confidence and abilities to analyze literature, and increases their interest in discussing it. Describes how the author, in her college-level introductory literature course, used Shel Silverstein's "The Giving Tree" (a children's…

  15. Literary Genres in Poetic Texts from the Dead Sea Scrolls

    Science.gov (United States)

    Pickut, William Douglas

    2017-01-01

    Among the texts of the Dead Sea Scrolls, there are four literary compositions that bear the superscriptional designations shir and mizmor. These designations correspond directly to superscriptional designations provided many times in both the now-canonical Psalter and the various witnesses to those texts unearthed at Qumran. On its face, this fact…

  16. Measuring Literary Reading Motivation: Questionnaires Design and Pilot Testing

    Science.gov (United States)

    Chrysos, Michail

    2017-01-01

    This study aims to present the design and pilot testing procedures of the two specific self-report questionnaires were used to measure the two key aspects of reading motivation, self-efficacy and intrinsic motivation in the field of literary (narrative) reading, and the partial factors that jointly shape them. These instruments were outlined in…

  17. Ecological economics and literary communication: Axes of discourse ...

    African Journals Online (AJOL)

    Ecological economics and literary communication: Axes of discourse in Ifeanyi Izuka's Travails of the black gold. ... and environmental messages that affect the econiche, and for exploring human conditions and values as characters react to extraordinary economic and ecological situations that have universal application.

  18. The Use of "Literary Fiction" to Promote Mentalizing Ability.

    Science.gov (United States)

    Pino, Maria Chiara; Mazza, Monica

    2016-01-01

    Empathy is a multidimensional process that incorporates both mentalizing and emotional sharing dimensions. Empathic competencies are important for creating interpersonal relationships with other people and developing adequate social behaviour. The lack of these social components also leads to isolation and exclusion in healthy populations. However, few studies have investigated how to improve these social skills. In a recent study, Kidd and Castano (2013) found that reading literary fiction increases mentalizing ability and may change how people think about other people's emotions and mental states. The aim of our study was to evaluate the effects of reading literary fiction, compared to nonfiction and science fiction, on empathic abilities. Compared to previous studies, we used a larger variety of empathy measures and utilized a pre and post-test design. In all, 214 healthy participants were randomly assigned to read a book representative of one of three literary genres (literary fiction, nonfiction, science fiction). Participants were assessed before and after the reading phase using mentalizing and emotional sharing tests, according to Zaki and Ochsner' s (2012) model. Comparisons of sociodemographic, mentalizing, and emotional sharing variables across conditions were conducted using ANOVA. Our results showed that after the reading phase, the literary fiction group showed improvement in mentalizing abilities, but there was no discernible effect on emotional sharing abilities. Our study showed that the reading processes can promote mentalizing abilities. These results may set important goals for future low-cost rehabilitation protocols for several disorders in which the mentalizing deficit is considered central to the disease, such as Autism Spectrum Disorders and Schizophrenia.

  19. Deconstruction Literary Theory and a Creative Reading of "The Great Gatsby."

    Science.gov (United States)

    Dennis, Deborah; Trotman, Charlene C.

    Through the mid-1980s, resistance to contemporary literary theory (especially Jacques Derrida's philosophy of deconstruction) took the form of a bitter debate that enlivened literary journals and Modern Language Association meetings. The debate continues even today, with traditional literary critics rejecting deconstruction as nihilistic and…

  20. Database in Theory and Practice: The Bibliography of Irish Literary Criticism

    Science.gov (United States)

    Howell, Sonia

    2013-01-01

    Focusing on "The Bibliography of Irish Literary Criticism" (BILC, 2010), a bibliographical database of Irish literary criticism developed by humanities and information and communications technology (ICT) researchers in NUI Maynooth, this chapter investigates the opportunities and implications afforded the field of Irish literary studies…

  1. Intravitreal methotrexate infusion for proliferative vitreoretinopathy

    Directory of Open Access Journals (Sweden)

    Sadaka A

    2016-09-01

    Full Text Available Ama Sadaka,1 Robert A Sisk,1–3 James M Osher,1,3 Okan Toygar,4 Melinda K Duncan,5 Christopher D Riemann1,3 1Department of Ophthalmology, University of Cincinnati College of Medicine, 2Department of Opthalmology, Cincinnati Children’s Hospital Medical Center, 3Cincinnati Eye Institute, Cincinnati, OH, USA; 4Department of Ophthalmology, Bahcesehir University Medical Faculty, Istanbul, Turkey; 5Department of Biological Sciences, University of Delaware, Newark, DE, USA Purpose: The purpose of this study was to evaluate intravitreal methotrexate infusion (IMI during pars plana vitrectomy (PPV for retinal detachment in patients with high risk for the development of proliferative vitreoretinopathy (PVR.Methods: Patients presenting with severe recurrent PVR with tractional retinal detachment and/or a history of severe ocular inflammation were treated with IMI. Clinical outcomes were determined from a retrospective medical chart review.Results: Twenty-nine eyes presenting with either tractional retinal detachment and recurrent PVR (n=22 or a history of severe inflammation associated with high PVR risk (n=7 received IMI during PPV. Best-corrected visual acuity at 6 months was ≥20/200 in 19 of 29 eyes (66% and remained stable or improved compared with initial presentation in 24 of 29 eyes (83%. At the last follow-up examination, the retinas of 26 of 29 eyes (90% remained attached after IMI while three eyes required another reattachment procedure. Three additional eyes (10% developed recurrent limited PVR without recurrent RD and were observed. No complications attributable to IMI occurred during a mean follow-up of 27 months.Conclusion: Eyes at high risk for PVR development due to a history of prior PVR or intraocular inflammation had a low incidence of PVR following IMI at the time of PPV for RD repair. No significant safety issues from IMI were observed in this series. Keywords: tractional retinal detachment, recurrent retinal detachment, pars

  2. Proliferative and non-proliferative lesions of the rat and mouse integument.

    Science.gov (United States)

    Mecklenburg, Lars; Kusewitt, Donna; Kolly, Carine; Treumann, Silke; Adams, E Terence; Diegel, Kelly; Yamate, Jyoji; Kaufmann, Wolfgang; Müller, Susanne; Danilenko, Dimitry; Bradley, Alys

    2013-01-01

    The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) project is a joint initiative of the societies of toxicological pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP). Its aim is to develop an internationally-accepted nomenclature for proliferative and non-proliferative lesions in laboratory rodents. A widely accepted international harmonization of nomenclature in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and will provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists. The purpose of this publication is to provide a standardized nomenclature for classifying microscopical lesions observed in the integument of laboratory rats and mice. Example colour images are provided for most lesions. The standardized nomenclature presented in this document and additional colour images are also available electronically at http://www.goreni.org. The nomenclature presented herein is based on histopathology databases from government, academia, and industrial laboratories throughout the world, and covers lesions that develop spontaneously as well as those induced by exposure to various test materials. (DOI: 10.1293/tox.26.27S; J Toxicol Pathol 2013; 26: 27S-57S).

  3. The differential proliferative ability of satellite cells in Lantang and Landrace pigs.

    Directory of Open Access Journals (Sweden)

    Xiu-qi Wang

    Full Text Available Here, for the first time, we evaluate the hypothesis that the proliferative abilities of satellite cells (SCs isolated from Lantang (indigenous Chinese pigs and Landrace pigs, which differ in muscle characteristics, are different. SCs were isolated from the longissimus dorsi muscle of neonatal Lantang and Landrace pigs. Proliferative ability was estimated by the count and proliferative activity of viable cells using a hemocytometer and MTT assay at different time points after seeding, respectively. Cell cycle information was detected by flow cytometry. Results showed that there was a greater (P<0.05 number of SCs in Lantang pigs compared with Landrace pigs after 72 h of culture. The percentage of cell population in S phase and G(2/M phases in Lantang pigs were higher (P<0.05, while in G(0/G(1 phase was lower (P<0.05 in comparison with the Landrace pigs. The mRNA abundances of MyoD, Myf5, myogenin and Pax7 in SCs from Lantang pigs were higher (P<0.05, while those of myostatin, Smad3 and genes in the mammalian target of rapamycin (mTOR pathway (with the exception of 4EBP1 were lower (P<0.05 than the Landrace pigs. Protein levels of MyoD, myogenin, myostatin, S6K, phosphorylated mTOR and phosphorylated eIF4E were consistent with the corresponding mRNA abundance. Collectively, these findings suggested that SCs in the two breeds present different proliferative abilities, and the proliferative potential of SCs in Lantang pigs is higher than in Landrace pigs.

  4. Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts.

    Science.gov (United States)

    Sitte, N; Merker, K; von Zglinicki, T; Grune, T

    2000-03-01

    One of the highlights of age-related changes of cellular metabolism is the accumulation of oxidized proteins. The aging process on a cellular level can be treated either as the ongoing proliferation until a certain number of cell divisions is reached (the Hayflick limit) or as the aging of nondividing cells, that is, the age-related changes in cells without proliferation. The present investigation was undertaken to reveal the changes in protein turnover, proteasome activity, and protein oxidation status during proliferative senescence. We were able to demonstrate that the activity of the cytosolic proteasomal system declines dramatically during the proliferative senescence of human MRC-5 fibroblasts. Regardless of the loss in activity, it could be demonstrated that there are no changes in the transcription and translation of proteasomal subunits. This decline in proteasome activity was accompanied by an increased concentration of oxidized proteins. Cells at higher proliferation stages were no longer able to respond with increased degradation of endogenous [(35)S]-Met-radiolabeled proteins after hydrogen peroxide- or quinone-induced oxidative stress. It could be demonstrated that oxidized proteins in senescent human MRC-5 fibroblasts are not as quickly removed as they are in young cells. Therefore, our study demonstrates that the accumulation of oxidized proteins and decline in protein turnover and activity of the proteasomal system are not only a process of postmitotic aging but also occur during proliferative senescence and result in an increased half-life of oxidized proteins.

  5. Bilateral proliferative retinopathy in B-cell acute lymphoblastic leukemia

    Directory of Open Access Journals (Sweden)

    Devesh Kumawat

    2018-01-01

    Full Text Available A 4-year-old child with B-cell acute lymphoblastic leukemia presented with vitreous hemorrhage due to proliferative retinopathy in both eyes. Pars plana vitrectomy was performed in both eyes to clear nonresolving vitreous hemorrhage after systemic stabilization. Visual recovery was limited by the disc drag in the right eye and subfoveal exudation in the left eye. Etiopathogenesis and management of proliferative retinopathy in acute leukemias are discussed.

  6. Benign Proliferative Breast Lesions and Risk of Cancer

    Directory of Open Access Journals (Sweden)

    Serap Erel

    2010-06-01

    Full Text Available Benign breast lesions (BBL includes a wide variety of histologic entities, which have been broadly classified into non-proliferative lesions, proliferative lesions without atypia, and hyperplasia with atypia. With the increased use of mammography, more benign lesions are being detected, and in order to estimate the risk of breast cancer for specific histologic categories is of great importance to guide clinical management. Women with proliferative lesions without atypia are at slightly increased risk of subsequent breast cancer, whereas women with proliferative lesions with atypia have a higher risk. The risk is 1.5- 2-fold in women with proliferative lesions without atypia, 4-5-fold in women with proliferative lesions with atypia, and 8-10 fold in women with ductal carcinoma in situ. Age at diagnosis of BBL, menopausal status, family history of breast cancer in a first-degree relative, and time since BBL diagnosis on risk of breast cancer are important for risk evaluation. [Archives Medical Review Journal 2010; 19(3.000: 155-167

  7. Literary Criticism Fiction: the Wacław Borowy–Manfred Kridl polemic

    Directory of Open Access Journals (Sweden)

    Maciej Gorczyński

    2016-03-01

    Full Text Available The paper The Fictions of Literary Criticism refers to a polemic between Manfred Kridl and Waclaw Borowy which was conducted in several articles published in the years 1936–1957. The polemic played a significant role in the development of modern Polish literary criticism. The matter of dispute was a new method of literary criticism announced by Kridl in his renowned Introduction to the Research of Literary Work (1936. The main topics of the discussion were the problems of the literary process, the evaluation of a literary work and the uses of scientific methods in humanities. The paper’s author pays attention especially to the rhetorical and literary means of argumentation which were used in the creation of this unusual form of non-fiction.

  8. Literary text reading and conversation: beyond ethnomethodology boundaries

    Directory of Open Access Journals (Sweden)

    Viviana Suárez Galvis

    2014-01-01

    Full Text Available This article leaves aside ethnomethodological approaches to conversation, and aims at opening the debate about the need of conceiving it under the light of pedagogical principles that position it as a propitious discursive gender to express the emotional, aesthetics, thoughtful, and intellectual meetings embodied while reading literary texts. Such interest arose from a research centered on finding the existing relationships between conversation and construction of aesthetical-literary experiences. The results show that students get a pleasant feeling when giving sense to what they read, and this encourages them to share with others their significant experiences when reading, allowing the internal process of meaning construction and the dialogic strengthening of the experiences to be connected.

  9. A canonical-literary reading of Lamentations 5

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    Shinman Kang

    2009-08-01

    Full Text Available This article presents a canonical and literary reading of Lamentations 5 in the context of the book of Lamentations as a whole. Following the approach by Vanhoozer (1998, 2002 based on speech-act theory, the meaning of Scripture is sought at canonical level, supervening the basic literary level. In Lamentations, as polyphonic poetic text, the speaking voices form a very important key for the interpretation of the text. In the polyphonic text of Lamentations, the shifting of the speaking voices occurs between Lamentations 1 and 4. Lamentations 5 is monologic. The theories of Bakhtin (1984 are also used to understand the book of Lamentations. In this book, chapter 5 forms the climax where Jerusalem cries to God. We cannot, however, find God’s answer to this call in Lamentations; we can find it only within the broader text of the Christian canon.

  10. I read. You read? Challenges and possibilities in working with literary literacy

    Directory of Open Access Journals (Sweden)

    Sayonara Abrantes de Oliveira

    2017-07-01

    Full Text Available This article is the result of a project linked to the Institutional Program of Scientific Initiation Scholarships for Higher Education (PIBIC-EM. The program’s objective was to analyze the contributing factors for the process of reading literacy training in order to verify how young people make their choices of literary texts, as well as know the difficulties and facilities they face in contact with these genres. To do so, we used the quantitative qualitative research through the application of a questionnaire, consisting of open questions, and applied to the students of the Integrated in Information Technology and Integrated Technician in the Environment of the Federal Institute of Education, Science and Technology of Paraíba (IFPB/campus Sousa courses. We also analyzed the perceptions derived from the observations of the Reader Club of the same campus, in an attempt to verify how the intervention of activities that mediate literary literacy favors the stimulus to the reading formation. Based on the data analysis, we observed that the student's distance element from reading is the lack of incentive, that is, the construction of an atmosphere that surrounds him, both in the classroom and in the other environments that welcome him. To overcome this, it is necessary for the teacher to have a theoretical-methodological apparatus guiding in his classes, since mediation favors literary literacy, having as support the Receptional Method and a conception of reading that articulates the interactional to the discursive, helping in the organization and selection of texts, in order to achieve the objectives of the formation of the reader.

  11. The Use of ?Literary Fiction? to Promote Mentalizing Ability

    OpenAIRE

    Pino, Maria Chiara; Mazza, Monica

    2016-01-01

    Empathy is a multidimensional process that incorporates both mentalizing and emotional sharing dimensions. Empathic competencies are important for creating interpersonal relationships with other people and developing adequate social behaviour. The lack of these social components also leads to isolation and exclusion in healthy populations. However, few studies have investigated how to improve these social skills. In a recent study, Kidd and Castano (2013) found that reading literary fiction i...

  12. Authorship attribution and author profiling of Lithuanian literary texts

    OpenAIRE

    Kapočiūtė-Dzikienė, Jurgita; Utka, Andrius; Šarkutė, Ligita

    2015-01-01

    In this work we are solving authorship attribution and author profiling tasks (by focusing on the age and gender dimensions) for the Lithuanian language. This paper reports the first results on literary texts, which we compared to the results, previously obtained with different functional styles and language types (i.e., parliamentary transcripts and forum posts). Using the Naïve Bayes Multinomial and Support Vector Machine methods we investigated an impact of...

  13. The literary myth of the double in entertainment media content

    OpenAIRE

    Robson Souza dos Santos

    2011-01-01

    This article discusses how the myth of the literary double stands in entertainment media, becoming a recurrent figure of cinema productions, and, later on, of soap operas, the main entertainment vehicle in latin-american countries. Frequently, the image of the double or stunt-man, in literature and soap opera productions, has been directly associated with the creature’s desire of becoming creator, and that myth is the main focus of discussion in this article.

  14. The League of Extraordinary Gentlemen as (Literary) History

    DEFF Research Database (Denmark)

    Backe, Hans-Joachim

    2017-01-01

    Alan Moore and Kevin O’Neill’s series The League of Extraordinary Gentlemen, published since 1999, depicts a world which is populated by characters of fiction, from Allan Quatermain and Captain Nemo to James Bond and Harry Potter. The result is not only a meta-fictional bricolage of cornerstones ...... about the feedback between history and literary history through the lens of comics and the medium’s own development....

  15. Literary Aesthetics in the Narration of Dagara Folktales

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    Martin Kyiileyang

    2016-12-01

    Full Text Available Dagara folktales, like other African folktales, are embedded with various literary aesthetic features related to structure, language and performance. This paper examines major literary aesthetics found in Dagara folktales. The methodology used is based on the collection, analysis and interpretation of selected Dagara folktales gathered through fieldwork. The focus of the paper is on the structure and the language of Dagara folktales. The argument of this paper is grounded on the Structuralist Theory as seen in Gerard Genette’s Narrative Discourse which offers the basic constituents and techniques of narrative. Genette proposes various categories of narrative which cover Time, Mood and Voice. Genette’s narrative structure suggests that the various categories and subcategories emphasise that the narrative is a complex structure in which the narratee is largely present in the various strata of the structure. Genette is concerned with the macro-text of the recit, that is, the ordering of events in the narrative. The study revealed that there are similarities and differences in the structure and the language of Dagara folktales in relation to other African folktales. Keywords: Dagara People, Folktale, Literary Aesthetics, Performance, Structuralist Theory

  16. Literary Translation and Cultural Challenges: JhumpaLahiri's The Namesake

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    Sura M. Khrais

    2017-01-01

    Full Text Available This paper discusses how the nature of literary translation differs from other forms of translation by looking at practical difficulties and challenges notable in the Arabic translation of Lahiri's novel The Namesake (2003. The difficulties discussed are cultural differences which have created “untranslatable” cultural-bound words and phrases, as well as specialized vocabulary. The paper explores the conflict between the translator's duty to accuracy and his/her duty to literary translation as an art form. One problem faced by the prose-translator is finding terms in his or her own language that are faithful as much as possible to the meaning of certain words in S.L. For example, there are words which describe specific rituals or those related to typical architecture, fabrics, and cookery; these and many others represent the specific culture of the original text and the translator needs to be careful when translating them. The researcher finally suggests that there is a need to expand the perimeters of  translation studies specially those dealing with literary prose because the translators and researchers lay more emphasis on the translation of poetry.

  17. Two Centuries of Literary Competition between Iran and the Subcontinent

    Directory of Open Access Journals (Sweden)

    سعید شفیعیون

    2010-05-01

    Full Text Available Safavid period is one of the most important historical periods of old Iran with regard to foreign relations. Among these, cultural and political relations with India are outstanding due to historical and mostly peaceful backgrounds, especially in the field of Persian language and literature. The influence of Persian literature on India was so much that this country became not only a rich and fruitful place for Iranian poets and literary figures, it also became the origin of another type of Persian literature. Although Iranian poets and literary figures, due to access to innate resources of this language and culture, were considered as the model, the attempts of cultural figures of the Subcontinent had local color and were different from Iranian linguistic and cultural criteria and norms. Because of this, there were a lot of critical controversies over the correctness and eloquence of literary works of Persian speakers of India. Iranians accussed them of doing unfounded innovations and linguistic experiences and these people, instead, claimed that they had the right to do so on the basis of certain reasons.

  18. Vitreous vascular endothelial growth factor concentrations in proliferative diabetic retinopathy versus proliferative vitreoretinopathy.

    Science.gov (United States)

    Citirik, Mehmet; Kabatas, Emrah Utku; Batman, Cosar; Akin, Kadir Okhan; Kabatas, Naciye

    2012-01-01

    To assess vitreous vascular endothelial growth factor (VEGF) concentrations in proliferative diabetic retinopathy (PDR) in comparison to proliferative vitreoretinopathy (PVR). Vitreous samples were collected from 69 eyes of 69 patients with traumatic lens dislocation (n = 10), grade B PVR with rhegmatogenous retinal detachment (n = 13), grade C PVR with rhegmatogenous retinal detachment (n = 14), PDR with vitreous hemorrhage (n = 18), and PDR with vitreous hemorrhage and tractional retinal detachment (n = 14). Vitreous fluid samples were obtained at vitrectomy, and the levels of VEGF were measured by enzyme-linked immunosorbent assay. The mean vitreous level of VEGF was 15.14 ± 5.22 pg/ml in eyes with grade B PVR, 99.15 ± 38.58 pg/ml in eyes with grade C PVR, 4,534.01 ± 1,193.28 pg/ml in eyes with vitreous hemorrhage secondary to PDR, 5,157.29 ± 969.44 pg/ml in eyes with vitreous hemorrhage and tractional retinal detachment secondary to PDR, and 16.19 ± 5.76 pg/ml in eyes of the control group with traumatic lens dislocation. Vitreous VEGF concentrations were significantly higher in the patients with grade C PVR, PDR with vitreous hemorrhage and PDR with vitreous hemorrhage and tractional retinal detachment in comparison to the control patients (p < 0.05). A significant alteration was not observed in patients with grade B PVR (p = 0.55). Vitreous VEGF concentrations are increased in PDR and grade C PVR. The high VEGF concentrations could suggest a possible effect of VEGF on advanced PVR. Copyright © 2011 S. Karger AG, Basel.

  19. uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERS

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    Mariana Rodrigues Faleiro

    2013-06-01

    Full Text Available Prostatic lesions such as prostatic intraepithelial neoplasia (PIN and proliferative inflammatory atrophy (PIA are studied in human and canine species due to their malignance potential. The plasminogen activator (PA system has been suggested to play a central role in cell adhesion, angiogenesis, inflammation, and tumor invasion. The urokinase-type plasminogen activator receptor (uPAR is a component of the PA, with a range of expression in tumor and stromal cells. In this study, uPAR expression in both canine normal prostates and with proliferative disorders (benign prostatic hyperplasia-BPH, proliferative inflammatory atrophy-PIA, prostatic intraepithelial neoplasia-PIN, and carcinoma-PC was evaluated by immunohistochemistry in a tissue microarray (TMA slide to establish the role of this enzyme in extracellular matrix (ECM remodeling and in the processes of tissue invasion. A total of 298 cores and 355 diagnoses were obtained, with 36 (10.1% normal prostates, 46 (13.0% with BPH, 128 (36.1% with PIA, 74 (20.8% with PIN and 71 (20.0% with PC. There is variation in the expression of uPAR in canine prostate according to the lesion, with lower expression in normal tissue and with BPH, and higher expression in tissue with PIA, PIN and PC. The high expression of uPAR in inflammatory and neoplastic microenvironment indicates increased proteolytic activity in canine prostates with PIA, PIN, and PC.

  20. Mechanisms of Inflammation in Proliferative Vitreoretinopathy: From Bench to Bedside

    Directory of Open Access Journals (Sweden)

    Stavros N. Moysidis

    2012-01-01

    Full Text Available Proliferative vitreoretinopathy (PVR is a vision-threatening disease and a common complication of surgery to correct rhegmatogenous retinal detachment (RRD. Several models of the pathogenesis of this disease have been described with some of these models focusing on the role of inflammatory cells and other models focusing on the role of growth factors and cytokines in the vitreous which come into contact with intraretinal and retinal pigment epithelial cells. New experiments have shed light on the pathogenesis of PVR and offer promising avenues for clinical intervention before PVR develops. One such target is the indirect pathway of activation of platelet-derived growth factor receptor alpha (PDGRα, which plays an important role in PVR. Clinical trials assessing the efficacy of 5-fluorouracil (5-FU and low-molecular-weight heparin (LMWH, daunorubicin, and 13-cis-retinoic acid, among other therapies, have yielded mixed results. Here we review inflammatory and other mechanisms involved in the pathogenesis of PVR, we highlight important clinical trials, and we discuss how findings at the bench have the potential to be translated to the bedside.

  1. “The Writer Is Essentially Indiscrete.” On the Literary Gossip of a Dutch Literary Celebrity

    Directory of Open Access Journals (Sweden)

    Bax Sander

    2017-11-01

    Full Text Available In contemporary media culture, literary writers arouse the fascination of media fans by awakening in them the desire for the authentic by publishing autobiographical novels or other forms of life narrative. In doing so, they run the risk of becoming part of media’s large gossip mechanism that plays such a central role nowadays. The public conversation about the books of writers such as the Dutch author Connie Palmen - whose Logboek van een onbarmhartig jaar will be the main case study of this article - becomes focused on the elements of truth and authenticity and ignores the literary or fictional construction of the work. This article discusses the question whether this leaves any room for contemporary star authors to distinguish themselves from media gossipers.

  2. Comprehension of atypical literary text and scholastic achievement

    Directory of Open Access Journals (Sweden)

    Božin Aurel A.

    2009-01-01

    Full Text Available With the aim of gaining insight into literary text comprehension and the linkage between that comprehension and scholastic achievement during the first years of schooling, a research was conducted on the sample of 152 third and fourth grade pupils from one urban and one rural school. After having read silently a selected atypical excerpt from one literary text, interviewed pupils filled out the questionnaire constructed for the purposes of this research starting from the 11 categories of text comprehension singled out based on the theory of comprehension and interpretation of literary text and the current curriculum. In the first part of the research we applied the Children's orientation scale by Malka Margalit, and school marks were used as a measurement of scholastic achievement. Research results point out that, among other things, inferring on the basis of what has been read poses the greatest difficulty for third and fourth graders, that is, that almost three quarters of them are not capable of determining the meaning of some representative sentences from that text. In the positive sense, it was established that almost three quarters of them perceive beautiful poetic expressions and about 80% of them can at least to a certain extent recognize character descriptions, emotional situations and moods, that is, discover significant facts. Answers to the questions regarding the majority of categories of text comprehension are significantly correlated with scholastic achievement. As expected, the highest correlations between the measures on text comprehension categories are with the marks in native (Serbian language. Partial correlations between the measures on certain categories of text comprehension and measurements of scholastic achievement (excluding the influence of feeling of coherence are not significantly different from bivariate. Based on the obtained data, authors conclude that the utilized system of categories can be a useful tool for

  3. Ethnic boundaries in national literary histories: Classification of ethnic minority fiction authors in American, Dutch and German anthologies and literary history books, 1978-2006

    NARCIS (Netherlands)

    P.P.L. Berkers (Pauwke)

    2009-01-01

    textabstractThis article compares the classification of ethnic minority fiction writers in American, Dutch and German literary anthologies and literary history books for the period of 1978-2006. Using content analyses, ethnic boundaries are much stronger in Dutch and German textbooks than in their

  4. Possible mechanisms for arsenic-induced proliferative diseases

    Energy Technology Data Exchange (ETDEWEB)

    Wetterhahn, K.E.; Dudek, E.J.; Shumilla, J.A. [Dartmouth College and Medical School, Hanover, NH (United States)] [and others

    1996-12-31

    Possible mechanisms for cardiovascular diseases and cancers which have been observed on chronic exposure to arsenic have been investigated. We tested the hypothesis that nonlethal levels of arsenic are mitogenic, cause oxidative stress, increase nuclear translocation of trans-acting factors, and increase expression of genes involved in proliferation. Cultured porcine vascular (from aorta) endothelial cells were used as a model cell system to study the effects of arsenic on the target cells for cardiovascular diseases. Treatment of postconfluent cell cultures with nonovertly toxic concentrations of arsenite increased DNA synthesis, similar to the mitogenic response observed with hydrogen peroxide. Within 1 hour of adding noncytotoxic concentrations of arsenite, cellular levels of oxidants increased relative to control levels, indicating that arsenite promotes cellular oxidations. Arsenite treatment increased nuclear translocation of NF-{kappa}B, an oxidative stress-responsive transcription factor, in a manner similar to that observed with hydrogen peroxide. Pretreatment of intact cells with the antioxidants N-acetylcysteine and dimethylfumarate prevented the arsenite-induced increases in cellular oxidant formation and NF-KB translocation. Arsenite had little or no effect on binding of NF-KB to its DNA recognition sequence in vitro, indicating that it is unlikely that arsenite directly affects NF-KB. The steady-state mRNA levels of intracellular adhesion molecule and urokinase-like plasminogen activator, genes associated with the active endothelial phenotype in arteriosclerosis and cancer metastasis, were increased by nontoxic concentrations of arsenite. These data suggest that arsenite promotes proliferative diseases like heart disease and cancer by activating oxidant-sensitive endothelial cell signaling and gene expression. It is possible that antioxidant therapy would be useful in preventing arsenic-induced cardiovascular disease and cancer.

  5. Proliferative changes in nonpalpable breast lesions detected by mammography

    International Nuclear Information System (INIS)

    Vega, A.; Delgado, A.; Ortega, E.; Garijo, F.; Mosquera, J.; Sogo, C.; Alvarez, A.

    2000-01-01

    To analyze retrospectively the radiological findings in nonpalpable breast lesions detected by mammography that lead to the performance of surgical biopsy, resulting in a histological diagnosis of proliferative breast disease with and without atypia. From two Spanish hospitals, 421 women with 429 biopsies indicative of the presence of proliferative breast disease with and without atypia were selected out of a total of 1252 surgical biopsies in nonpalpable lesions that proved to be benign. Age, personal and familial history of breast cancer, reason for requesting the mammography and radiological findings that had indicated the need for surgical biopsy were recorded for each patient. The diagnosis was proliferative breast disease (epithelial hyperplasia) in 347 women with 354 biopsies and atypical hyperplasia in the remaining 74 women with 75 biopsies, representing 28% and 6%, respectively, of the 1252 biopsies of lesions found to be benign. In 221 of the 354 cases of epithelial hyperplasia (62%) and 45 of the 75 cases of atypical hyperplasia (60%), the presence of calcifications was the most common radiological findings leading to biopsy (p<0.05). Parenchymal distortion, with or without calcifications, was the second most common radiological sign. The histological study revealed a close relationship between these proliferative events and radial scars. Calcifications are the radiological finding that most frequently indicate the need for surgical biopsy in nonpalpable lesions that results in a diagnosis of proliferative breast disease with and without atypia. (Author) 12 refs

  6. Language of the Earth: Exploring Natural Hazards through a Literary Anthology

    Science.gov (United States)

    Malamud, B. D.; Rhodes, F. H. T.

    2009-04-01

    This paper explores natural hazards teaching and communications through the use of a literary anthology of writings about the earth aimed at non-experts. Teaching natural hazards in high-school and university introductory Earth Science and Geography courses revolves mostly around lectures, examinations, and laboratory demonstrations/activities. Often the results of such a course are that a student 'memorizes' the answers, and is penalized when they miss a given fact [e.g., "You lost one point because you were off by 50 km/hr on the wind speed of an F5 tornado."] Although facts and general methodologies are certainly important when teaching natural hazards, it is a strong motivation to a student's assimilation of, and enthusiasm for, this knowledge, if supplemented by writings about the Earth. In this paper, we discuss a literary anthology which we developed [Language of the Earth, Rhodes, Stone, Malamud, Wiley-Blackwell, 2008] which includes many descriptions about natural hazards. Using first- and second-hand accounts of landslides, earthquakes, tsunamis, floods and volcanic eruptions, through the writings of McPhee, Gaskill, Voltaire, Austin, Cloos, and many others, hazards become 'alive', and more than 'just' a compilation of facts and processes. Using short excerpts such as these, or other similar anthologies, of remarkably written accounts and discussions about natural hazards results in 'dry' facts becoming more than just facts. These often highly personal viewpoints of our catostrophic world, provide a useful supplement to a student's understanding of the turbulent world in which we live.

  7. Mitogenic Activity of a Water-Soluble Adjuvant (Bu-WSA) Obtained from Bacterionema matruchotii: IV. Synergistic Effects of Bu-WSA on Concanavalin A-Induced Proliferative Response of Human Peripheral Blood Lymphocytes.

    Science.gov (United States)

    Nitta, Toshimasa; Okumura, Seiichi; Tsushi, Masao; Nakano, Masayasu

    1982-07-01

    Butanol-extracted water-soluble adjuvant (Bu-WSA) obtained from Bacterionema matruchotii was cultured with peripheral blood mononuclear cells (PBM) in the presence of sub- and/or supra-optimal mitogenic concentrations of concanavalin A (Con A). The addition of Bu-WSA resulted in increased tritiated thymidine incorporation above that produced by Con A alone. Bu-WSA by itself is not mitogenic for PBM and in fact produced a decrease in thymidine uptake compared to the control. We investigated the response of subpopulation(s) of PBM to Bu-WSA, Con A and a mixture of Bu-WSA and Con A. Separation of PBM into purified T cells, B cells and macrophages showed that cell-cell cooperation of T cells with B cells or macrophages is necessary for the observed synergistic effect of Bu-WSA with Con A. A marked increase in thymidine incorporation by the mixture of T and B cell populations occurred, while only a small amount of thymidine was incorporated when the B cell population was absent. Mitomycin treatment revealed that the response could be ascribed to the T-cell response with a B-cell helper effect. Moreover, Con A and Bu-WSA appeared to act on the same T cell population. This model may provide unique information about the activation of human peripheral blood T cells compared with the activation of these cells by other mitogens. © owned by Center for Academic Publications Japan (Publisher).

  8. Mitogenic activity of a water-soluble adjuvant (Bu-WSA) obtained from Bacterionema matruchotii. IV. Synergistic effects of Bu-WSA on Concanavalin A-induced proliferative response of human peripheral blood lymphocytes.

    Science.gov (United States)

    Nitta, T; Okumura, S; Tsushi, M; Nakano, M

    1982-01-01

    Butanol-extracted water-soluble adjuvant (Bu-WSA) obtained from Bacterionema matruchotii was cultured with peripheral blood mononuclear cells (PBM) in the presence of sub- and/or supra-optimal mitogenic concentrations of concanavalin A (Con A). The addition of Bu-WSA resulted in increased tritiated thymidine incorporation above that produced by Con A alone. Bu-WSA by itself is not mitogenic for PBM and in fact produced a decrease in thymidine uptake compared to the control. We investigated the response of subpopulation(s) of PBM to Bu-WSA, Con A and a mixture of Bu-WSA and Con A. Separation of PBM into purified T cells, B cells and macrophages showed that cell-cell cooperation of T cells with B cells or macrophages is necessary for the observed synergistic effect of Bu-WSA with Con A. A marked increase in thymidine incorporation by the mixture of T and B cell populations occurred, while only a small amount of thymidine was incorporated when the B cell population was absent. Mitomycin treatment revealed that the response could be ascribed to the T-cell response with a B-cell helper effect. Moreover, Con A and Bu-WSA appeared to act on the same T cell population. This model may provide unique information about the activation of human peripheral blood T cells compared with the activation of these cells by other mitogens.

  9. Anti-proliferative effect of RCE-4 from Reineckia carnea on human cervical cancer HeLa cells by inhibiting the PI3K/Akt/mTOR signaling pathway and NF-κB activation.

    Science.gov (United States)

    Bai, Caihong; Yang, Xiaojiao; Zou, Kun; He, Haibo; Wang, Junzhi; Qin, Huilin; Yu, Xiaoqin; Liu, Chengxiong; Zheng, Juyan; Cheng, Fan; Chen, Jianfeng

    2016-06-01

    Cervical cancer is the second leading cause of cancer deaths in women worldwide. In recent years, the studies find that inflammation is a critical component of tumor progression, and the ideal therapeutic methods should be aimed at the inflammation reaction triggers. (1β,3β,5β,25S)-spirostan-1,3-diol1-[α-L-rhamnopyranosyl-(1 → 2)-β-D-xylopyranoside] (RCE-4) was the main active composition of Reineckia carnea (Andr.) Kunth. It significantly induced apoptosis in cervical cancer Caski cells through the mitochondrial pathway in our previous studies; however, its underlying mechanism remains poorly understood. This study aimed to further evaluate the effect of RCE-4 on human cervical cancer HeLa cells. Based on this observation, we investigated the anti-cervical cancer effect of RCE-4 by modulating phosphatidylinositol 3-kinase/protein kinase-B/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway, nuclear factor-kappa B (NF-κB) activation, and inflammation-related key factors in HeLa cells. The results indicated that the HeLa cell was the most sensitive with an IC50 of 7.01 μM; RCE-4 significantly promoted the release of cellular lactate dehydrogenase (LDH); increased DNA fragmentation and apoptosis; reduced PI3K, Akt, mTOR, and NF-κBp65 phosphorylation levels; increased the Bax and cleaved poly (ADP-ribose) polymerase (PARP) protein levels; suppressed Bcl-2 protein expression; elevated the Bax/Bcl-2 expression ratio; and decreased the interleukin-1 beta (IL-1β) and interleukin-6 (IL-6) mRNA expressions in HeLa cells in a concentration-dependent manner. These findings suggest that RCE-4 exerted beneficially anti-cervical cancer effect on HeLa cells, mainly inhibiting PI3K/Akt/mTOR signaling pathway phosphorylation and NF-κB activation, promoting HeLa cell apoptosis. Graphical abstract Anti-tumor effect of RCE-4 on HeLa cells.

  10. CONTEXTUAL APPROACH TO LITERARY CRITICISM: DOSTOEVSKY AND PSYCHOANALYSIS

    Directory of Open Access Journals (Sweden)

    V. G. Kalashnikov

    2016-01-01

    Full Text Available The aim of this article is to demonstrate the possibilities of application of the contextual approach, developed in pedagogy and psychology, in the process of literary analysis. Initially contextual approach was developed by A. A. Verbitsky as a methodology of education. A key category of this approach was the context, interpreted A. A. Verbitsky as a psychological phenomenon. Accordingly, in this paper on the basis of later research context is understood as a psychological mechanism of semantic, objectified in external forms of test patches, social and communicative situations, etc. Now contextual approach became general psychological methodology, which led to the possibility of its application in various fields of the humanities in particular – in psycholinguistic literary studies, where the notion of «context » is used in-depth psychological interpretation. Methods. The contextual approach developed by A. A. Verbitsky as the main component of methodology of education became the main instrument of the research stated in the publication. Besides a field of the general education, this approach is applicable to various private spheres – to educational aspect of education, and also to methodology of teaching various subject matters – mathematicians, biology, foreign languages, etc. The contextual approach at the level of allpsychological methodology has allowed to apply it in various fields of humanitarian knowledge, in particular in literary researches with a strongly pronounced psychological perspective. The contextual analysis corresponding to approach has been chosen as a method of work.Results. Based on A. A. Verbitsky’s interpretation and results of the latest researches the author shows that the context is a semantic mechanism, objectified in external forms of test fragments, social and communicative situations, etc. The following types of contexts are allocated: microcontext of a personality and works of an author, a mesocontext

  11. New Transnational Literary Histories on the World Scene

    Directory of Open Access Journals (Sweden)

    Remo Ceserani

    2013-12-01

    Full Text Available Il saggio discute il rapporto sempre più problematico fra storia della letteratura e identità nazionale. Dopo aver esaminato alcune storie recenti che continuano a privilegiare la dimensione nazionale ed esclusivamente letteraria della materia trattata, si sofferma su alcune interessanti esperienze di storie che trattano la produzione culturale e letteraria di intere zone geografiche, a prescindere dalle identità statali, culturali e linguistiche di singoli Paesi e nazioni (per esempio: l’Europa centro-orientale, la penisola iberica, l’intero continente sudamericano. Fra i testi presi in esame: la Storia della letteratura ungherese, a cura di B. Ventavoli (2002-2004, la Storia della letteratura polacca, a cura di L. Marinelli (2004, la Geografia e storia della civiltà letteraria rumena nel contesto europeo, a cura di B. Mazzoni e A. Tarantino (2010, la History of the Literary Cultures of East-Central Europe, a cura di M. Cornis-Pope e J. Neubauer (2004-2010, la New History of German Literature, a cura di D. E. Wellbery e J. Ryan (2004, la New History of French Literature, a cura di D. Hollier (1998, la Comparative History of Literatures in the Iberian Peninsula, a cura di F. Cabo Aseguinolaza, A. Abuín Gonzales e C. Domínguez (2010, la New Literary History of America, a cura di G. Marcus e W. Sollors (2009 e le Literary Cultures of Latin America, a cura di M. Valdés e D. Kadir (2004.

  12. Cognitive literary Anthropology and Neurohermeneutics. A theoretical Proposal

    Directory of Open Access Journals (Sweden)

    Federica Claudia Abramo

    2017-06-01

    Full Text Available Following Wolfgang Iser’s studies, literary criticism could no longer avoid a confrontation with the phenomenology of the act of reading. This has led the analysis of a literary text towards new researches regarding the reader’s response theory. In particular, it is impossible to define the field of literary investigation, its coordinates and characteristics, without considering the anthropological dimention which defines the epistemological nature of literature itself. We propose in this study a new approach that we call “neurohermeneutic approach”. Unlike an analytical or descriptive approach, the neurohermeneutic approach investigates broth the relations that the reader’s mind establishes with the text figurations and how these figurations stimulates the reader’s mind in that inexhaustible, always new and surprising act of the reading.   A partire dagli studi di Wolfgang Iser, la riflessione critica non ha più potuto evitare il confronto con la fenomenologia dell’atto della lettura, e questo ha condotto l’analisi del testo fino alle recenti ricerche in merito alla reader’s response theory. Soprattutto risulta ormai impossibile definire il campo di indagine letterario, le sue caratteristiche e coordinate, a prescindere da un affondo nella dimensione antropologica che definisce la natura epistemologica della letteratura stessa. Proponiamo in questo studio un nuovo approccio che definiamo “neuroermeneutico” e che, a differenza di un approccio analitico o descrittivo, indaga sia le relazioni che la mente del lettore instaura con le figurazioni del testo, sia come queste figurazioni sollecitino la mente del lettore in quell’atto inesauribile, sempre nuovo e sorprendente, della lettura.

  13. Bloomsday 100: the making of a literary legend.

    Science.gov (United States)

    Kaplan, Robert M

    2004-06-01

    As a background to the centenary of Bloomsday, to explore the circumstances in which James Joyce wrote "Ulysses", noting the autobiographical elements and unique style, including the stream-of-consciousness technique that depicted the inner life of the characters. Selected quotations are used to illustrate these points. Joyce wanted to show that the epic and the heroic is in our lives every day. "Ulysses" defined the literary consciousness of the 20th century. By basing the novel about a day in the life of three ordinary characters on Homer's epic account of an 18 year voyage, Joyce re-established the link between 20th century consciousness and classical times.

  14. The theme revenge in the cinema: a literary philosophical approach

    Directory of Open Access Journals (Sweden)

    Fábio José de Queiroz

    2016-04-01

    Full Text Available In this article, the focus is revenge, taking as a starting point two cinematographic works –Once upon a time in this article is revenge, taking as a starting point two cinematographic works­ once upon a time in West, by Sergio Leone, and also colors: White by Krzysztof Kieslowsk. Without the direct influence of a purely artistic appreciation of both movies, this is about a study of literary­ philosophical lineage by relying on classical seeks to provide an theoretical analyze of the theme, avoiding falling into an empiricist interpretation, trivial and shallow of the object.

  15. Write it right a little blacklist of literary faults

    CERN Document Server

    Bierce, Ambrose

    2010-01-01

    Amusing and thought-provoking, this A-to-Z compendium outlines common oral and written gaffes. Ambrose Bierce, a celebrated literary wit, assembled his informative compilation in 1909 from many years of observations and notes. He advocates precision in language, offering alternatives to grammatical lapses and inaccurate word choices.Moneyed for Wealthy: ""The moneyed men of New York."" One might as sensibly say, ""The cattled men of Texas,"" or, ""The lobstered men of the fish market."" Name for Title and Name: ""His name was Mr. Smith."" Surely no babe was ever christened Mister. Juncture m

  16. Post-digital Books and Disruptive Literary Machines

    DEFF Research Database (Denmark)

    Pold, Søren Bro; Andersen, Christian Ulrik

    2014-01-01

    Abstract The e-book has been launched several times during the last decades and the book’s demise has often been predicted. Furthermore networked and electronic literature has already established a long history. However, currently we witness several interesting artistic and literary experiments...... of –and critical reflection on post- or semio-capitalism, and furthermore we will discuss how literature functions in a post-industrial software culture such as the one presented by Apple, Amazon and Google. Keywords: digital literature, Kindle, Apple, Ubermorgen, Korabiewski, post-digital, post...

  17. What Renaissance Literary Theory Tells us about Climate Communication

    Science.gov (United States)

    Guenther, G. J.

    2017-12-01

    Many current debates in climate communication-to convey the consensus or not to convey the consensus; to frighten people or encourage them-seem to center on the question of how to discuss climate science and its ability to predict climate impacts. By examining the Renaissance literary theory that represents poets as better teachers than philosophers and scientists, this paper argues that climate advocates should redefine climate communication to include a variety of artistic discourses that make meaning in order to inspire people into political action.

  18. Utterance and Function in Genre Studies: A Literary Perspective

    DEFF Research Database (Denmark)

    Auken, Sune

    2015-01-01

    of the complexities involved when Genre Studies confront genres whose utterances are more complex than the “homely discourses” usually discussed in RGS. Formal and thematic features play a far too significant role in literary works to be explicable simply as derivations from function alone. But this is not limited...... to formal and thematic interpretations of genre, by allowing the utterances themselves to re-enter center stage. This enables an improved understanding of complex genres. It also revives close reading as a viable approach to understanding genre and thus to inform the rhetorical, linguistic, and sociological...

  19. On variation of word frequencies in Russian literary texts

    Science.gov (United States)

    Kargin, Vladislav

    2016-03-01

    We study the variation of word frequencies in Russian literary texts. Our findings indicate that the standard deviation of a word's frequency across texts depends on its average frequency according to a power law with exponent 1/2 volatility (that is, higher "burstiness"). A latent factor model has been estimated to investigate the structure of the word frequency distribution. The findings suggest that the dependence of a word's frequency volatility on its average frequency can be explained by the asymmetry in the distribution of latent factors.

  20. Literary study and evolutionary theory : A review essay.

    Science.gov (United States)

    Carroll, J

    1998-09-01

    Several recent books have claimed to integrate literary study with evolutionary biology. All of the books here considered, except Robert Storey's, adopt conceptions of evolutionary theory that are in some way marginal to the Darwinian adaptationist program. All the works attempt to connect evolutionary study with various other disciplines or methodologies: for example, with cultural anthropology, cognitive psychology, the psychology of emotion, neurobiology, chaos theory, or structuralist linguistics. No empirical paradigm has yet been established for this field, but important steps have been taken, especially by Storey, in formulating basic principles, identifying appropriate disciplinary connections, and marking out lines of inquiry. Reciprocal efforts are needed from biologists and social scientists.

  1. Proliferative, necrotizing and crescentic immune complex-mediated glomerulonephritis in a cat

    Directory of Open Access Journals (Sweden)

    Carolyn Gross

    2015-09-01

    Full Text Available Case Summary A 5-year-old cat was examined for vomiting and anorexia of 2 days’ duration. Azotemia, hyperphosphatemia and hypoalbuminemia were the main biochemical findings. Serial analyses of the urine revealed isosthenuria, proteinuria and eventual glucosuria. Hyperechoic perirenal fat was detected surrounding the right kidney by ultrasonography. Histopathologic evaluation of ante-mortem ultrasound-guided needle biopsies of the right kidney was consistent with proliferative, necrotizing and crescentic glomerulonephritis with fibrin thrombi, proteinaceous and red blood cell casts, and moderate multifocal chronic-active interstitial nephritis. Owing to a lack of clinical improvement, the cat was eventually euthanized. Post-mortem renal biopsies were processed for light microscopy, transmission electron microscopy and immunofluorescence. This revealed severe focal proliferative and necrotizing glomerulonephritis with cellular crescent formation, podocyte injury and secondary segmental sclerosis. Ultrastructural analysis revealed scattered electron-dense deposits in the mesangium, and immunofluorescence demonstrated positive granular staining for λ light chains, consistent with immune complex-mediated glomerulonephritis. Severe diffuse acute tubular epithelial injury and numerous red blood cell casts were also seen. Relevance and novel information To our knowledge, this is the first report of naturally occurring proliferative, necrotizing and crescentic immune complex glomerulonephritis in a cat.

  2. PRACTICE OF USING DIFFERENT WAYS OF ANALYSIS OF A FICTION WORK AT LITERARY READING LESSONS

    OpenAIRE

    Valeriy Syrotenko; Olena Bondarenko

    2017-01-01

    Analysis of a fiction work at school, in particular in primary school, is based on the methodological studies of the literary analysis, that envisages application of various ways of analysis of a literary text used for the adequate appreciation of its semantic and expressive features. This article is devoted exactly to this range of problems. Literary reading lessons in 2-4th forms set a task of forming schoolchildren’s literary competence, the integral part of which is their ability to an...

  3. Reconsidering the Nature of the Unconscious: A Question on Psychoanalysis in Literary Studies

    Directory of Open Access Journals (Sweden)

    L. Suharjanto, SJ

    2017-01-01

    Full Text Available Psychoanalysis has been used invariably in literary studies, as it helps literary interpretation to touch the often-puzzling-dimension of motives and feelings in literary works. The domination of psychoanalysis in the twentieth century, however, has been questioned with the new awareness that the unconscious mind is not innate but constructed. Such a disposition challenges not only the practice of using psychoanalysis in literary studies but also the validity of psychoanalysis itself.   DOI: https://doi.org/10.24071/llt.2012.150104

  4. Proliferative signaling initiated in ACTH receptors

    Directory of Open Access Journals (Sweden)

    C.F.P. Lotfi

    2000-10-01

    Full Text Available This article reviews recent results of studies aiming to elucidate modes of integrating signals initiated in ACTH receptors and FGF2 receptors, within the network system of signal transduction found in Y1 adrenocortical cells. These modes of signal integration should be central to the mechanisms underlying the regulation of the G0->G1->S transition in the adrenal cell cycle. FGF2 elicits a strong mitogenic response in G0/G1-arrested Y1 adrenocortical cells, that includes a rapid and transient activation of extracellular signal-regulated kinases-mitogen-activated protein kinases (ERK-MAPK (2 to 10 min, b transcription activation of c-fos, c-jun and c-myc genes (10 to 30 min, c induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h, and d onset of DNA synthesis stimulation within 8 h. ACTH, itself a weak mitogen, interacts with FGF2 in a complex manner, blocking the FGF2 mitogenic response during the early and middle G1 phase, keeping ERK-MAPK activation and c-Fos and cyclin D1 induction at maximal levels, but post-transcriptionally inhibiting c-Myc expression. c-Fos and c-Jun proteins are mediators in both the strong and the weak mitogenic responses respectively triggered by FGF2 and ACTH. Induction of c-Fos and stimulation of DNA synthesis by ACTH are independent of PKA and are inhibited by the PKC inhibitor GF109203X. In addition, ACTH is a poor activator of ERK-MAPK, but c-Fos induction and DNA synthesis stimulation by ACTH are strongly inhibited by the inhibitor of MEK1 PD98059.

  5. Esculetin exerts anti-proliferative effects against non-small-cell lung carcinoma by suppressing specificity protein 1 in vitro.

    Science.gov (United States)

    Lee, Ra H; Jeon, Young-Joo; Cho, Jin H; Jang, Jeong-Yun; Kong, Il-Keun; Kim, Seok-Ho; Kim, MinSeok S; Chung, Hak-Jae; Oh, Keon B; Park, Seon-Min; Shin, Jae-Cheon; Seo, Jae-Min; Ko, Sungho; Shim, Jung-Hyun; Chae, Jung-Il

    2017-01-01

    Esculetin, a coumarin derivative, is a phenolic compound isolated from Artemisia capillaris, Citrus limonia, and Euphorbia lathyris. Although it has been reported to have anti-inflammatory, anti-oxidant, and anti-proliferative activities in several human cancers, its anti-proliferative activity against non-small-cell lung carcinoma (NSCLC) and the molecular mechanisms involved have not been adequately elucidated. In this study, we used two NSCLC cell lines (NCI-H358 and NCI-H1299) to investigate the anti-proliferative activity and apoptotic effect of esculetin. Our data showed that esculetin-treated cells exhibited reduced proliferation and apoptotic cell morphologies. Intriguingly, the transcription factor specificity protein 1 (Sp1) was significantly suppressed by esculetin in a dose- and time-dependent manner. Furthermore, the levels of p27 and p21, two key regulators of the cell cycle, were up-regulated by the esculetin-mediated down-regulation of Sp1; the level of a third cell-cycle regulator, survivin, was decreased, resulting in caspase-dependent apoptosis. Therefore, we conclude that esculetin could be a potent anti-proliferative agent in patients with NSCLC.

  6. Anti-proliferative effect of Moringa oleifera Lam (Moringaceae) leaf ...

    African Journals Online (AJOL)

    Purpose: To investigate the in vitro anti-proliferative effect and mechanism of action of Moringa oleifera Lam. leaf extract on human colon carcinoma HCT116 cell line. Methods: M. oleifera leaves were extracted with methanol. It was fractionated by Sephadex LH-20 column chromatography. Several fractions were identified ...

  7. Treatment and prevention of porcine proliferative enteropathy with oral tiamulin.

    Science.gov (United States)

    McOrist, S; Smith, S H; Shearn, M F; Carr, M M; Miller, D J

    The effect of an oral treatment or prevention programme, incorporating the antibiotic tiamulin, on the development of proliferative enteropathy in experimentally challenged pigs was studied. Twenty weaner pigs were challenged orally with a virulent inoculum of Lawsonia intracellularis strain LR189/5/83, a British isolate of the causative agent of porcine proliferative enteropathy, and seven control pigs were dosed with a buffer solution. Seven of the 20 challenged pigs were left untreated; they gained less weight than the controls and three of them developed mild to moderate diarrhoea two weeks after the challenge. All seven developed lesions, six visible grossly, of proliferative enteropathy, and numerous intracellular L intracellularis were detected in sections of the intestines examined three weeks after the challenge. To test a 'prevention' dosing strategy for tiamulin, six of the challenged pigs were dosed orally with 50 ppm tiamulin, incorporated in a 2 per cent stabilised premix, given from two days before the challenge until they were euthanased. To test a 'treatment' strategy, the remaining group of seven challenged pigs were dosed orally with 150 ppm tiamulin given in the premix from seven days after challenge until they were euthanased. All the control pigs and the 13 pigs treated with tiamulin, either before or after challenge, remained clinically normal and had no specific lesions of proliferative enteropathy in sections of the intestines examined post mortem.

  8. Proliferative verrucous leukoplakia; a critical appraisal of the diagnostic criteria

    NARCIS (Netherlands)

    Carrard, V.C.; Brouns, E.R.E.A.; van der Waal, I.

    2013-01-01

    Since its introduction in the literature in 1985, the term proliferative verrucous leukoplakia (PVL) has been the subject of an ongoing discussion with regard to its definition. Widespread or multifocal occurrence of oral leukoplakia is not just synonymous to PVL. In the present treatise the

  9. Dutch guidelines for diagnosis and therapy of proliferative lupus nephritis

    NARCIS (Netherlands)

    van Tellingen, A.; Voskuyl, A. E.; Vervloet, M. G.; Bijl, M.; de Sevaux, R. G. L.; Berger, S. P.; Derksen, R. H. W. M.; Berden, J. H. M.

    Proliferative lupus nephritis is a strong predictor of morbidity and mortality in patients with systemic lupus erythematosus. Despite improvements in the management of lupus nephritis, a significant number of the patients do not respond to immunosuppressive therapy and progress to end-stage renal

  10. SCIENCE FICTION IN HISTORICAL AND CULTURAL LITERARY DISCOURSE

    Directory of Open Access Journals (Sweden)

    Simona Siderevičiūtė

    2014-04-01

    Full Text Available This work intends to complement literary studies in science fiction. It discusses the history of global science fiction, overviews the most cha­racteristic features of its historical periods, and provides an introduction to Lithuanian science fiction, indicating its main features and topics. In the context of culture, science fiction is often defined as a literary genre with the emphasis on its nature as fiction. Only rarely are the history of the origin of science fiction, its variations, and the pioneers of science fiction whose works are still highly valued taken into account. Science fiction is often criticized through the filter of preconceived ideas that consider this type of literature to be “friv­olous.” This article discusses the possible reasons for such an approach. In Lithuania, this genre is still associated only with pop literature, and its expression cannot yet equal the works of foreign authors. The basic classical motifs of global science fiction found in Lithuanian science fiction include: representatives of extraterrestrial civilizations and human contact with them, scientists and inventors, agents of military institutions, and space travel. Lithuanian science fiction writers follow the tra­ditions of global science fiction when using these classical motifs; however, a general lack of original and individual themes, motifs, and manifestations may be observed.

  11. Modifying the explanation of Anvari Abivardi’s literary theory

    Directory of Open Access Journals (Sweden)

    Fatemeh Hakima

    2016-02-01

    Full Text Available Abstract   In the first place, the literary theory is about finding an answer to the question on what makes a verbal message into a work of art . This is related to the particular distinction of Lingual arts from other arts, and other types of Lingual behaviors . That is why literary theory is in the first position among literary studies. (Ahmadi, 1996: 1st volume/77 One of the fundamental aspects of literary studies is interpreting ancient texts from the perspective of the poet or writer’s own literary theory . On this basis, this article aims to discuss the literary theory and poetry structure of Anvari . Indisputably, Anvari’s structure is special and it is certainly based on the perspective, insight and cultural and social conditions in which it grew and formed. Each poet is the composer of their poetry and oratory and Anvary, himself, is the most informed person about his elocution method. He mentioned the elocution method in several places in his Divan:   However, you looking into poetry styles   All taken into account the best style is mine (Anvari, 1958: 1st volume/85   Accordingly, his Divan has been subjected to scrutiny, and judgment criteria have been derived from the verses of the poet .   Anvari believed that poetry is the result of integrating content with discourse whose output is captured hearts . He called poets the granters of speech and in composing poetry, he believed content is prior to discourse. He has an opinion that the container of discourse does accommodate content that on this basis he approached the ideas of " modern hermeneutics ”. He praised original meaning- which was not adopted by other poems- and he described proper poetry using graceful and delicate characteristic. In fact, in his viewpoint, a poem which has original meaning and graceful and delicate verse is a literary discourse which influences the reader .  From his viewpoint:  1- Improvisation and spontaneity   2- Composing in any literary

  12. Psychos’ Haunting Memories: A(n (Uncommon Literary Heritage

    Directory of Open Access Journals (Sweden)

    Maria Antónia Lima

    2015-07-01

    Full Text Available In our times, one of the most prevailing forms of terror is certainly the psychological terror. In the history of literature and cinema, it’s impossible to forget some very widely known characters called psychos, especially those created by Edgar Allan Poe, Robert Bloch, Stephen King, Bret Easton Ellis, Sarah Kane and Patrick McGrath. Usually, they are haunted not only by their own private memories, but also by a literary memory that associates them to a common heritage, as if each psychotic character belonged to a very old gothic family, in which every member had been cursed to inherit the disease of his ancestors or the sins of his fathers. Haunted by images of their past, that recurrently return to the present, these psychos defy the barriers of time and all the traditional distinctions between reality and imagination, because one can never be sure if the stories are really about murders or about victims of their very diseased minds. Uncertainties and doubts disturb the reader as they also disturb the main character in search of a lost identity. Keywords: Psychos, Terror, Haunting Memories, Literary Heritage, Poe.

  13. Twentieth-Century Latin American Literary Studies and Cultural Autonomy

    Directory of Open Access Journals (Sweden)

    Naomi Lindstrom

    1995-06-01

    Full Text Available Since the 1920s, when scholars first began to specialize in Latin American writing, the subject of Latin American literary studies has grown from a small subset of Spanish and Portuguese literary research and teaching to become the largest field within Hispanism and a significant presence in comparative literature. The expansion of their place in the academic world has often prompted students of Latin American literature to wonder whether, in being swept into the mainstream, their field has not left out of account the historical situations of Latin American nations. These reflections lead critics back to a problem that has troubled Latin American thinkers since Independence: the achievement, or erosion, of cultural autonomy. Though undeniably close to major powers, the Latin American nations are unequal partners in trade and cultural exchange. Corresponding to their uneven and shifting relations with Europe and later the United States, their cultural life evolves following a distinctive historical dynamic. This article considers recent efforts by scholars and essayists to characterize the features that distinguish Latin America from more politically and economically advantaged nations. Special attention goes to those scholars who, drawing on anthropological research, examine communicative and expressive practices of indigenous origin, and those who borrow from economic theory to view Latin America as shaped by its history of dependence on more powerful nations and regions.

  14. Three Literary Works, Three Countries, Three Dimensions of Modernity

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    Yücel KARADAŞ

    2010-12-01

    Full Text Available This article studies three literary works—two dramatic works and a novel—in terms of the modernization processes in three countries, of the class relationships to which these processes gave rise, the classes lost or gained power and of the character types arisen in these processes. These three countries are Turkey, Russia and England. And the three literary works are Yakup Kadri Karaosmanoglu‘s Kiralik Konak from Turkish literature, Chekhov‘s The Cherry Orchard from Russian literature and Bernard Shaw‘s Heartbreak House from English literature. During the selection of the first two works the facts that the modernization processes in Turkey and Russia began around the same time and that there were certain wars and different kinds of relationship between the two countries in the last two centuries of the Ottoman Empire were taken into consideration. Moving from this point, we aim to compare and contrast the Turkish-Ottoman modernization with the modernization process in Russia. On the other hand, the reason behind the selection of Heartbreak House is that it is thought that a comparison or a contrast with an industrialized country—England—that completed its modernization in the 19th and the beginning of the 20th centuries would facilitate understanding the different levels of modernization experienced in Turkey and Russia at the time. Thus, the article analyzes the abovementioned works from a sociological perspective to arrive at some conclusion about the modernization processes and socio-economical upheavals in three countries

  15. Como fazer uma sociologia da singularidade? Autoria e campo literário How to make sociology of singularity? Authorship and literary field

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    Andréa Borges Leão

    2009-10-01

    Full Text Available Se o ponto de partida de uma sociologia do estatuto do criador em literatura é o funcionamento social das obras e das condições de sua produção em um espaço de posicionamentos específi cos, o percurso da análise deve acompanhar a lógica dos valores que fundamenta o trabalho de criação. A moderna atividade literária não escapa às tensões entre a afirrmação dos valores associados à singularidade do indivíduo e as regras coletivas que confi guram e orientam as relações no mundo literário, a exemplo dos poderes de consagração e reconhecimento. Daí os embates entre as formas de comportamento individual e a organização das instituições sociais que regulam o trabalho literário. O objetivo deste artigo é situar o escritor, enquanto sujeito historicamente submetido a um “regime de singularidade”, face à estrutura do campo literário. Para tanto, estabelece um possível diálogo entre a abordagem compreensiva da socióloga Nathalie Heinich e a ciência das obras elaborada por Pierre Bourdieu. Palavras-chave: Campo literário. Singularidade. Autoria literária. Direito do autor. Instituições literárias. If the starting point of sociology of the author statute in literature is the social functioning of the pieces and also the conditions of their production in specifi c space, the way to analysis should follow the logic which is the base of that creation. The modern literary activity isn’t free of the tension between the affi rmation of individual singularity associated value and the collective rules that form and guide the literary world relations, like the ways of acclaim and acknowledgment. From there comes the shock between the ways of individual behavior and the organization of social institutes that set the literary world. The goal of this article is to place the author, while a historical subject of a “singularity regime”, in front of the structure of the literary fi eld. In order to achieve that, the

  16. In vitro Anti-proliferative and Apoptotic Activities of Eurycoma ...

    African Journals Online (AJOL)

    HP

    Results: F1 showed unremarkable growth inhibition rate while F2 and F3 ... Treatment with F2 and F3 (100 µg/ml) for 96 h increased cell death from 3.3 to 95.5 and 76.3 %, ... three decades [4]. ... [9], breast [10] and cervical cancers [11] have ... 60 was obtained from American Type Culture ... acted as a negative control.

  17. New cyclic peptides with osteoblastic proliferative activity from Dianthus superbus.

    Science.gov (United States)

    Tong, Yun; Luo, Jian-Guang; Wang, Rui; Wang, Xiao-Bing; Kong, Ling-Yi

    2012-03-01

    Two new cyclic peptides, dianthins G-H (1 and 2), together with the known dianthin E (3), were isolated from the traditional Chinese medicinal plant Dianthus superbus. The sequences of cyclic peptides 1 and 2 were elucidated as cyclo (-Gly(1)-Pro(2)-Leu(3)-Thr(4)-Leu(5)-Phe(6)-) and cyclo (-Gly(1)-Pro(2)-Val(3)-Thr(4)-Ile(5)-Phe(6)-), on the basis of ESI tandem mass fragmentation analysis, extensive 2D NMR methods and X-ray diffraction. The isolated three compounds all increase proliferation of MC3T3-E1 cells in vitro using MTT method. Copyright © 2012 Elsevier Ltd. All rights reserved.

  18. Antioxidant and Anti-proliferative Activities of Flavonoids from ...

    African Journals Online (AJOL)

    significant growth inhibitory effect on RKO cells with IC50 of 39.08 μmol/L and 17.68 μmol/L, respectively ..... YJ.. Essential oil from rhizomes of Ligusticum chuanxiong induces apoptosis in hypertrophic scar ... Liu H, Mou Y, Zhao J, Wang J, Zhou L, Wang M, Wang. D, Han J, Yu Z, Yang F. Flavonoids from Halostachys.

  19. U.S. National Certification in Literary Braille: History and Current Administration

    Science.gov (United States)

    Bell, Edward

    2010-01-01

    This article reports on a certification examination for teachers of students with visual impairments--the National Literary Braille Competency Test (NLBCT). It discusses the history, development, pilot testing, and validation of NLBCT and the creation of the National Certification in Literary Braille. Data on the current administration of the test…

  20. Ethnic boundaries in American, Dutch and German national literary policies, 1965-2005

    NARCIS (Netherlands)

    P.P.L. Berkers (Pauwke)

    2009-01-01

    textabstractThis article addresses the extent and ways in which ethnic diversity has been part of American, Dutch and German national literary policy from 1965 until 2005. By analyzing the content of policy documents of the National Endowment of the Arts and the Dutch and German Literary Fund, I

  1. Violent Children in Today's Schools: A Literary Review and a Behavior Management Plan for Administrators.

    Science.gov (United States)

    Moore, Paula; Karr-Kidwell, PJ

    This paper presents a relevant literary review and then develops a behavior-management program within schools encompassing social-skills training for all children. Both the literary review and this program can be used to educate administrators, educators, parents, and students about behaviors and warning signs associated with violent children. The…

  2. The Relationship between Home Literary Environments and Attitudes toward Reading in Ninth-Grade Students.

    Science.gov (United States)

    Kubis, Mary Ellen

    A study determined what variables in the home literary environments of ninth-grade students influenced their attitudes toward reading. Subjects, 316 students from 2 ninth-grade classes at 2 metropolitan high schools, were given the Estes Reading Attitude Scale and a researcher-developed, 30-question inventory of their home literary environment.…

  3. Edward Said's Worldliness, Amateurism and Heterotopia: Negotiating the Interdisciplinarity of Literary Theory, Canonicity, and Paradigm

    Science.gov (United States)

    Abu-Shomar, Ayman

    2016-01-01

    Literary criticism nowadays is essentially crossing the boundaries of disciplinarity and canonicity where literary theory has increasingly been shaped by overlapping concepts and branching out of theories as well as whipping out the limitations imposed by theory itself. The post-conditions of contemporaneity have imposed a view of reading and…

  4. Stylistic Performance through Affective Marking: A Case of Multilingual Literary Discourse

    Science.gov (United States)

    Chakravarty, Urjani

    2016-01-01

    This paper provides an overall analysis of how multi-lingual writer like Amitav Ghosh write about emotion in his literary text, and emphasize on how multilingual authors display emotion/affect through use of literary multilingualism (affective markers) combined with writer style. Through use of multiple strategies, they reduces the limitations of…

  5. Mapping the Demographic Landscape of Characters in Recent Dutch Prose : A Quantitative Approach to Literary Representation

    NARCIS (Netherlands)

    van der Deijl, Lucas; Pieterse, S.A.; Prinse, Marion; Smeets, Roel

    2016-01-01

    The lack of ethnic and gender diversity in the Dutch literary domain has recently been subject to discussions in the public debate. In the academic context, questions regarding diversity are studied either on a literary-sociological level (institutional approaches) or on the level of the individual

  6. The Literary Criticism and Memoirs of Juan Ramón Jiménez

    Directory of Open Access Journals (Sweden)

    Allen W. Phillips

    1983-01-01

    Full Text Available Equally as demanding of others as he was of himself, Juan Ramón Jiménez conceived of literary criticism as a serious and exacting task. The critic and the poet, standing side by side, are devoted to complementary activities of mutual enrichment. However fragmentary and partial the critical opinions of Juan Ramón may be (also outspoken and polemical in nature, they are invaluable as a personal historical and aesthetic guide to about fifty or sixty years of Hispanic literary development (1900-1960. Not to take them into account is to fail to recognize a highly important aspect of his total artistic personality. These varied critical texts are a product of a first rate intelligence and the sensibility of a writer of consummate discrimination who was endowed not only with an excellent memory but also a very special talent for appreciating the authentic. Juan Ramón as a critic is quick to praise (San Juan, Bécquer, Dario, Unamuno and Machado and at the same time strong in his censure of certain contemporaries. Several recently collected volumes of miscellaneous critical materials have resolved the bibliographical muddle for the initial study of this fundamental aspect of the poet, but still particularly important are the expressionistic portraits of Españoles de tres mundos , longer tributes to Valle, Ortega and Villaespesa as well as the extensive lectures delivered in his latter years. Examination of these pages gives us an historical and creative overview of the period in which he lived and worked in addition to original considerations about the evolution of Hispanic poetry. Of course, one of the constant focal points of his literary criticism was the modernist epoch of his early days, a movement or attitude which he considered to be a modern twentieth century renaissance. Together with detailed study of these two areas of historical and aesthetic nature, in the ensuing pages some conclusions are pointed out as to the essence of poetry

  7. Different proliferative capacity of lung fibroblasts obtained from control subjects and patients with emphysema

    NARCIS (Netherlands)

    Noordhoek, JA; Postma, DS; Chong, LL; Vos, JTWM; Kauffman, HF; Timens, W; van Straaten, JFM

    2003-01-01

    To characterize the possible role of a dysregulated proliferative capacity of pulmonary fibroblasts in insufficient tissue repair in lungs from patients with pulmonary emphysema, the authors undertook in vitro proliferative studies with pulmonary fibroblasts obtained from lung tissue of patients

  8. The Meaning and Significance of Contemporary Media in Collecting and Studying Croatian Oral Literary Heritage

    Directory of Open Access Journals (Sweden)

    Vanda Babić

    2013-05-01

    Full Text Available In the study of Croatian oral literary heritage, great importance present the records that have remained preserved as notes on documents, books, songs and poems as part of literary works. Records shows that oral literary text is the subject of research and study of oral heritage. However, the records themselves are not sufficient for studying oral literary text and its context. The text is accompanied by a recorded voice that faithfully represents the diction, rhythm, tone and color of the narrator voice. Videos shows the gestures, context and emotion of the narrator. Without the role of the modern media, oral literary records would be insufficient for studying fundamental aspects of communicativeness that can be interpreted as a context. The media of public communication greatly affects the expansion of the basic ideas of the oral transmission of text which is - storytelling.

  9. Representativeness in corpora of literary texts: introducing the C18P project

    Directory of Open Access Journals (Sweden)

    Gemeinböck, Iris

    2016-07-01

    Full Text Available Currently there are very few specialised corpora of literary texts that are tailored to the needs of literary critics who are interested in corpus stylistic analyses of prose fiction. Many existing corpora including literary texts were compiled for linguistic research interests and are often unsuitable for corpus stylistic purposes. The paper addresses three of the main problems: the absence of labelling of the texts for literary genre, the use of extracts, and the prevalence of linguistic periodisation schemes. C18P is a corpus of prose fiction designed specifically to address these issues. It traces the early development of the novel from 1700 up until the Victorian era. It can, for instance, be used for an analysis of the characteristic linguistic features of individual literary genres and forms. The following paper introduces the design of the corpus as well as some of its potential uses.

  10. The Novela Negra in a Transatlantic Literary Economy

    Directory of Open Access Journals (Sweden)

    Glen S. Close

    2014-06-01

    Full Text Available In the field of contemporary Hispanic literary studies, there would seem to be few areas of production so starkly determined by such triangulation as detective fiction, and particularly the subgenre of the novela negra. The contemporary, transnational Spanish-language genre descended from early twentieth-century U.S. hard-boiled writing. While the prestige of U.S. hard-boiled classics writers is evident in a multitude of explicit and implicit homages contained in the novela negra corpus, the dissemination of detective formulas was by no means a direct or unilinear transfer, but rather a complex process of irregular filtration through imports, translations, editions, pastiches and imitations over the course of the twentieth century. The primary poles of the triangulation that I describe here will correspond to those proposed by Ortega, but I will also follow his example by extending attention to other areas of Europe whose implication in this specific transatlantic interaction is appreciable.

  11. Teaching cultural competence using an exemplar from literary journalism.

    Science.gov (United States)

    Anderson, Kathryn L

    2004-06-01

    Fadiman's work of literary journalism, The Spirit Catches You and You Fall Down, was used as a case study to teach transcultural and other nursing concepts to undergraduate nursing students. Campinha-Bacote's model of cultural competence was used to organize transcultural nursing concepts in the course. Before and after the course, students completed assessments consisting of two cultural attitude questionnaires and a paper describing a personal experience with adherence and failure to adhere by a Mexican American client. After reading Fadiman's book and completing several short writing assignments examining key course concepts, student scores on the questionnaires were mostly unchanged. However, students demonstrated growth in cultural awareness and skill in their "after" papers. Results suggest that valid, reliable tools are needed to detect changes in cultural competence. Qualitative data suggest that students can begin the process of becoming culturally competent through the creative use of literature in nursing education.

  12. Some aspects of gender inequality in selected African literary texts

    Directory of Open Access Journals (Sweden)

    L.L. Kwatsha

    2009-07-01

    Full Text Available This article focuses on gender inequalities in selected African literary texts. I explore the way in which some African writers view gender inequalities and stereotypes in their characters. We will also be able to see who is involved and affected by these gender inequalities and how. Gender theory will be used as a framework. The aspects of gender that are discussed, include gender stereotypes, gender roles, gender identity, the superiority of men, inequality in polygamous marriages, sex roles, the sexual division of labour and arranged marriage. This study will also include the views of writers from other part of Africa. These views have a lot in common but sometimes they vary because of the influence and different ideologies of the society concerned.

  13. From Literary Classics to Twitter: Some Examples of Retelling

    Directory of Open Access Journals (Sweden)

    Claudia Cao

    2014-11-01

    Full Text Available After having defined the “microliterature” among the digital textual forms and after a brief analysis of its origin, this paper gives an overview of the three main narrative forms risen from Twitter, with particular attention for the widespread phenomenon of retellings. The aim of this study is to examine the two more diffused typologies of serial retelling ‒ the collective and the authorial form ‒ throughout the concept of convergence theorized by Jenkins (2006. Finally, the last example taken into consideration ‒ Twitterature (Penguin 2009, sixty retellings of literary classics reproducing the Twitter texts ‒ testifies the circularity and reciprocity of the osmosis process between literature and new media.

  14. The technique of flashback in selected Northern Sotho literary texts

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    M.J. Mojalefa

    2005-07-01

    Full Text Available This article aims at investigating and explaining the application of the technique of flashback in selected Northern Sotho literary texts. Five kinds of flashback are distinguished, namely external retrospection, internal retrospection, mixed retrospection, flashback to complicate events and flashback of similar events. These kinds of flashback have certain and specific functions, such as reminding readers of past events, foregrounding themes of the text, and so on. This technique is evident in a text when ordinary, everyday events turn out to be the key to surprising secrets that are revealed later. Though flashback seems to be similar to foreshadowing (prolepsis in that both techniques contain features of repetition and the narration of a specific experience, the techniques, however, differ in that flashback focuses on the elements of secrecy, suspense and surprise, and foreshadowing does not. This article also reveals that a relationship between flashback and the structure of detective stories can be indicated.

  15. Imagination, creation and literary origins: dreaming and waking

    Directory of Open Access Journals (Sweden)

    Catherine Farrar

    2012-01-01

    Full Text Available Quotation, allusion, mediumship and speaking with or through others’ voices is an established ad well-worked aspect of culture, indeed, it seems, across all cultures, an appropriate subject indeed for COMPASIO. So too has the inspiration artists have drawn for their creation from dreams and the voices of a world beyond themselves. This has been relatively well studied in such fields as visual art and music. Less attention, however, despite its clear centrality, has been given to literary creation. This paper, by a cultural anthropologist, uses a personal case study to illustrate how this can work through the interaction between dreams and narrative. The case here, though only singular in its detailed content and process has wider implications for the comparative anthropological and comparative study of culture, individuality, imagination and creativity.

  16. The literary and philosophical conceptions of Laza Kostić

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    Aleksić Slađana V.

    2016-01-01

    Full Text Available Laza Kostić, in the early seventies of the XIX century, opposed the utilitarianism of Nikolay Chernyshevsky and Svetozar Markovié, and advocated the idea of aestheticism in poetry and art. In his study about Jovan Jovanović Zmaj, Kostić had discovered two opposing processes in the poet, which he symbolically named the battle between the dragon and the nightingale. Kostić's conception about the origin of poetry is at the intersection of romanticist poetics about creation from divine inspiration, and a philosophical concept of the interference as a basic principle. The paper sheds light on the correspondence among the philosophical and literary views of Laza Kostić and his artistic work.

  17. The convent of Jericho in Brussels and its literary network

    Directory of Open Access Journals (Sweden)

    Stoop, Patricia

    2014-06-01

    Full Text Available The Augustinian convent of Jericho in Brussels was one of the main centres of textual, literary, and spiritual culture in the late medieval Low Countries. In addition to the large collection of manuscripts which the canonesses wrote for themselves, the sisters produced several books for people and institutions outside the convent walls. Thus the sisters were both important recipients as well as signifi cant producers of texts. This article will focus on the question of the origin of the texts and books that the sisters used to build their library. Additionally, attention will be paid to the external recipients of the books that the Jericho scribes made, in order to shed light on the as yet understudied exchange of texts and books to and from (female convents and the literary networks in which these religious institutions functioned.El convento de las agustinas Jericó en Bruselas fue uno de los centros más importantes de la cultura textual, literaria, y espiritual en los Países Bajos durante la Baja Edad Media. Además de la amplia colección de manuscritos que las canonesas escribieron para sí mismas, produjeron varios libros para personas e instituciones externas al convento. Las religiosas no solo eran receptoras importantes, sino también signifi cativas productoras de textos. El artículo se concentra en la cuestión de la proveniencia de los textos y libros que servían para crear su biblioteca. Se prestará asimismo atención a los destinatarios externos a los que se dirigieron las copistas de Jericó con el fin de arrojar luz sobre la hasta ahora poco estudiada dinámica de intercambio de textos y libros entre conventos (de mujeres y el exterior y las redes literarias en el marco de las cuales esas instituciones religiosas funcionaron.

  18. Rehabilitation effect of oral drug on the patients with proliferative diabetic retinopathy after operation

    Directory of Open Access Journals (Sweden)

    Wei Zu

    2014-08-01

    Full Text Available AIM:To observe the rehabilitation effect of oral Calcium Dobesilate Tablets and Epalrestat Tablets on the proliferative diabetic retinopathy(PDRpatients after vitrectomy.METHODS: After vitrectomy patients informed consent, they were randomly divided into intervention group and control group, and their vision and fundus were followed up and compared at 2d; 3, 6, 9, 12mo after operation.RESULTS: The recovery and sustainment of visual acuity, and subsiding of macular edema of patients in drug intervention group were significantly better than that in control group.CONCLUSION: PDR patients after vitrectomy actively orally take medicine to protect retina, which can improve vision and fundus rehabilitation.

  19. Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discovery

    DEFF Research Database (Denmark)

    Poulsen, Michael; Oh, Dong-Chan; Clardy, Jon

    2011-01-01

    and solitary Hymenoptera. Here we test this possibility by examining two species of solitary mud dauber wasps, Sceliphron caementarium and Chalybion californicum. We performed enrichment isolations from 33 wasps and obtained more than 200 isolates of Streptomyces Actinobacteria. Chemical analyses of 15...... and antibacterial activity. The prevalence and anti-microbial properties of Actinobacteria associated with these two solitary wasp species suggest the potential role of these Streptomyces as antibiotic-producing symbionts, potentially helping defend their wasp hosts from pathogenic microbes. Finding...... phylogenetically diverse and chemically prolific Actinobacteria from solitary wasps suggests that insect-associated Actinobacteria can provide a valuable source of novel natural products of pharmaceutical interest....

  20. Antimicrobial and Anti-Proliferative Effects of Skin Mucus Derived from Dasyatis pastinaca (Linnaeus, 1758

    Directory of Open Access Journals (Sweden)

    Virginia Fuochi

    2017-11-01

    Full Text Available Resistance to chemotherapy occurs in various diseases (i.e., cancer and infection, and for this reason, both are very difficult to treat. Therefore, novel antimicrobial and chemotherapic drugs are needed for effective antibiotic therapy. The aim of the present study was to assess the antimicrobial and anti-proliferative effects of skin mucus derived from Dasyatis pastinaca (Linnaeus, 1758. Our results showed that skin mucus exhibited a significant and specific antibacterial activity against Gram-negative bacteria but not against Gram-positive bacteria. Furthermore, we also observed a significant antifungal activity against some strains of Candida spp. Concerning anti-proliferative activity, we showed that fish mucus was specifically toxic for acute leukemia cells (HL60 with an inhibition of proliferation in a dose dependent manner (about 52% at 1000 μg/mL of fish skin mucous, FSM. Moreover, we did not observe effects in healthy cells, in neuroblastoma cells (SH-SY5Y, and multiple myeloma cell lines (MM1, U266. Finally, it exhibited strong expression and activity of chitinase which may be responsible, at least in part, for the aforementioned results.

  1. The use of analogy in pro-life argumentation

    Directory of Open Access Journals (Sweden)

    Simona Mazilu

    2012-11-01

    Full Text Available The paper is concerned with how analogy is strategically used in pro-life argumentation on abortion. Pragma-dialectics (van Eemeren and Grootendorst 1992 offers a set of critical questions by means of which I will evaluate the use of the argumentation based on a relation of analogy in terms of dialectical soundness. Examining various pro-life texts, I have noticed that the analogies employed remain unexplained. Therefore, despite the apparent similarities between abortion and the German holocaust or slavery, for instance, there are essential differences which are not mentioned. I claim that these analogies mainly have a rhetorical function, to operate what has been called by Micheli (2007: 960 “a transfer of emotional consensus”.

  2. Scoring radiologic characteristics to predict proliferative potential in meningiomas

    International Nuclear Information System (INIS)

    Hashiba, Tetsuo; Hashimoto, Naoya; Maruno, Motohiko; Izumoto, Shuichi; Suzuki, Tsuyoshi; Kagawa, Naoki; Yoshimine, Toshiki

    2006-01-01

    We investigated the feasibility of using radiologic characteristics to predict the proliferative potential in meningiomas. Our statistical analysis revealed that the presence of peritumoral edema, an ambiguous brain-tumor border, and irregular tumor shape were significantly correlated with a higher MIB-1 staining index (SI) value. We developed the following scoring system for specific features in each tumor: peritumoral edema (tumor with edema=1, tumor without edema=0); brain-tumor border (tumor with any ambiguous border=1, tumor circumscribed by a distinct rim=0); and tumor shape (tumor with irregular shape=1, tumor with smooth shape=0). Using Spearman's correlation coefficient analysis, we found a significant correlation (P<0.005) between total score calculated for each patient and SI value. Our findings suggest that the proliferative potential of meningiomas can be predicted using a less invasive preoperative examination focusing on the presence of peritumoral edema, ambiguous brain-tumor border, and irregular tumor shape. (author)

  3. Proliferative verrucous leukoplakia: an aggressive form of oral leukoplakia.

    Science.gov (United States)

    Shopper, Thomas P; Brannon, Robert B; Stalker, William H

    2004-01-01

    Proliferative verrucous leukoplakia (PVL) is an aggressive form of oral leukoplakia that is persistent, often multifocal, and refractory to treatment with a high risk of recurrence and malignant transformation. This article describes the clinical aspects and histologic features of a case that demonstrated the typical behavior pattern in a long-standing, persistent lesion of PVL of the mandibular gingiva and that ultimately developed into squamous cell carcinoma. Prognosis is poor for this seemingly harmless-appearing white lesion of the oral mucosa.

  4. Prolific plant regeneration through organogenesis from scalps of ...

    African Journals Online (AJOL)

    Four types of potting media comprising of sand, peat, sand + top soil + goat dung (3:2:1 v/v) and top soil + sand (1:1 v/v) were evaluated during acclimatization of the plantlets. Prolific shoot regeneration from scalps was obtained on MS medium containing 2.5 mM BAP, at 9.61 and 40.6 shoots per explant after 4 and 8 weeks ...

  5. Panretinal photocoagulation versus intravitreal injection retreatment pain in high-risk proliferative diabetic retinopathy

    Directory of Open Access Journals (Sweden)

    Célia Regina Farias de Araújo Lucena

    2013-02-01

    Full Text Available PURPOSE: To compare pain related to intravitreal injection and panretinal photocoagulation in the management of patients with high-risk proliferative diabetic retinopathy. METHODS: Prospective study including patients with high-risk proliferative diabetic retinopathy and no prior laser treatment randomly assigned to receive panretinal photocoagulation (PRP group or panretinal photocoagulation plus intravitreal ranibizumab (PRPplus group. In all patients, panretinal photocoagulation was administered in two sessions (weeks 0 and 2, and intravitreal ranibizumab was administered at the end of the first laser session in the PRPplus group. Retreatment was performed at weeks 16 and 32 if active new vessels were detected at fluorescein angiography. Patients in the PRPplus group received intravitreal ranibizumab and patients in the PRP group received 500-µm additional spots per quadrant of active new vessels. After the end of retreatment, a 100-degree Visual Analog Scale was used for pain score estimation. The patient was asked about the intensity of pain during the whole procedure (retinal photocoagulation session or intravitreal ranibizumab injection. Statistics for pain score comparison were performed using a non-parametric test (Wilcoxon rank sums. RESULTS: Seventeen patients from PRPplus and 14 from PRP group were evaluated for pain scores. There were no significant differences between both groups regarding gender, glycosylated hemoglobin and disease duration. Mean intravitreal injection pain (±SEM was 4.7 ± 2.1 and was significantly lower (p<0.0001 than mean panretinal photocoagulation pain (60.8 ± 7.8. Twelve out of 17 patients from the PRPplus group referred intensity pain score of zero, while the minimal score found in PRP group was found in one patient with 10.5. CONCLUSION: In patients with high-risk proliferative diabetic retinopathy who needed retreatment for persistent new vessels, there was more comfort for the patient when retreatment

  6. Atypical hyperplasia, proliferative fibrocystic change, and exogenous hormone use.

    Science.gov (United States)

    Zera, R T; Danielson, D; Van Camp, J M; Schmidt-Steinbrunn, B; Hong, J; McCoy, M; Anderson, W R; Linzie, B M; Rodriguez, J L

    2001-10-01

    The association between breast cancer development and exogenous hormone use (EHU) is suggested by indirect clinical evidence. We undertook this study to better define the relationship that EHU has with proliferative fibrocystic change (PFC) and atypical hyperplasia (AH). Women diagnosed with AH without associated carcinoma from January 1990 to December 1999 were compared with control subjects who underwent breast biopsy procedures during the same interval and who were diagnosed with either a proliferative fibrocystic change (PFC) or a nonproliferative fibrocystic change (NPFC). EHU was defined as the use of estrogen or progesterone taken together or separately within 3 months of biopsy. EHU was significantly higher in patients with AH compared with women with NPFC (P =.01). This observation was also significant if all proliferative change (both AH and PFC) was compared with NPFC (P =.03); it was not significant when PFC alone was compared with NPFC. No significant difference in EHU was demonstrated between women with AH and those with PFC. There is strong association between AH and EHU. These results support the theory that a continuum exists between hyperplasia and carcinoma and that EHU may influence the transition from one to the other in an undefined subset of women. We encourage our patients with AH to discontinue EHU.

  7. 78 FR 35642 - Certain TV Programs, Literary Works for TV Production and Episode Guides Pertaining to Same...

    Science.gov (United States)

    2013-06-13

    ... INTERNATIONAL TRADE COMMISSION [Docket No 2959] Certain TV Programs, Literary Works for TV... Certain TV Programs, Literary Works for TV Production and Episode Guides Pertaining to Same, DN 2959; the... importation of certain TV programs, literary works for TV production and episode guides pertaining to same...

  8. Relação entre a quantidade de AgNORS, atividade proliferativa e o estágio de desenvolvimento placentário em equinos Relationship between the amount of AgNORs, proliferative activity and stage of placental development in horses

    Directory of Open Access Journals (Sweden)

    Ana C.F. Mançanares

    2012-12-01

    silver nitrate and are related to the activity of rRNA synthesis and to the agility and speed of cell proliferation in the tissues studied. The objective of this study was to relate the amount of AgNORs, proliferative activity and stage of pregnancy in horses, using the coloring of Silver Nitrate. The embryonic attachments were collected, fixed in 10% buffered formaldehyde, embedded in paraplast and stained by silver nitrate. The groups were determined according to the gestational age. The amount of the corium NOR found in early pregnancy indicates the onset of cell activity, and in that the pregnancy progresses, the amount of NOR increases, suggesting higher activity and increased synthesis of their importance in maintaining the fetus. Contrary to what occurs in the corium, the quantification of NORs was higher in late pregnancy than in the beginning, suggesting the stabilization of these membranes in late pregnancy. The chorionic girdle and the yolk sac were found in early pregnancy and had lots of NORs, suggesting synthesis function and proliferation in early pregnancy, since their functions is maintenance of the embryo until the complete formation of the true placenta (chorio-allantoic membranes. We conclude that the membranes that develop in a progressive manner in accordance with the growing embryo/fetal (chorion, amnion and allantoic membranes have an increased number of NORs and the membranes that involute after the formation of the embryo/fetus (yolk sac and chorionic girdle have a decrease in number, suggesting a reduction in proliferative activity in these membranes.

  9. Synergy among rat T cells in the proliferative response to alloantigen

    International Nuclear Information System (INIS)

    Wright, P.W.; Loop, S.M.; Bernstein, I.D.

    1979-01-01

    A synergistic interaction in the proliferative response to alloantigen is described for mixtures of rat thymus and lymph node cells. The optimal conditions for synergy are quantitatively defined. Regression analysis of the slope of the dose-response curve has been utilized to estimate the degree of interaction in thymus--lymph node cell mixtures. The slope of the response of cell mixtures was noted to be significantly greater than the slope for the response of lympth node cells alone. Irradiation was shown to have a differential effect on the response of thymus and lymph node cells in mixtures. Irradiated thymus cells retained the capacity for synergy in mixtures, whereas irradiated lymph node cells did not. Additional studies have demonstrated that both de novo protein synthesis and specific antigen recognition by both responding cell populations in mixtures was required for maximal synergy. These studies demonstrate that synergy cannot be explained as an artifact of altered cell density in vitro. They establish that thymus cells and lymph node cells represent distinct subsets which manifest qualitatively different functions in the proliferative response to alloantigen. Thymus cells can respond directly to alloantigen by proliferation but also have the capacity to amplify the proliferative response of lymph node cells, a capacity which is resistant to X irradiation but requires recognition of alloantigen and de novo protein synthesis. Lymph node cells may similarly respond by proliferation to alloantigen but lack the amplifier activity of thymus cells. Synergy for rat lymphoidcells, like mouse lymphoid cells, has been shown to involve an interaction of thymus-derived lymphocytes

  10. Synthesis and Anti-Proliferative Effects of Mono- and Bis-Purinomimetics Targeting Kinases

    Directory of Open Access Journals (Sweden)

    Andrea Bistrović

    2017-11-01

    Full Text Available A series of mono-pyrrolo[2,3-d]pyrimidines 4a–4k, unsymmetrical bis-purine isosteres 5a–5e and symmetrical bis-pyrrolo[2,3-d]pyrimidines 6a and 6b connected via di(1,2,3-triazolylphenyl linker were synthesized by click chemistry. Whereas mono- 4g and bis-pseudopurine 5e showed selective inhibitory activities on cervical carcinoma (HeLa cells, bis-pyrrolo[2,3-d]pyrimidine 6b exhibited potent and selective anti-proliferative effect in the nanomolar range on pancreatic carcinoma (CFPAC-1 cells. Among these, compound 6b induced a significant reduction in the expression level of CDK9 (cyclin-dependent kinase 9/cyclin T1 in CFPAC-1 cells concomitant with attenuation of proliferative signaling mediated by c-Raf (rapidly accelerated fibrosarcoma and p38 MAP (mitogen-activated protein kinases. Our findings encourage further development of novel structurally related analog of 6b to obtain more selective anticancer agent for treating pancreatic cancer.

  11. Serbian Literary Magazine and avant-garde music

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    Vasić Aleksandar N.

    2005-01-01

    Full Text Available One of the most excellent periodicals in the history of Serbian literature Serbian Literary Magazine (1901-1914, 1920-1941, also played an exceptionally important part in the history of Serbian music criticism and essay literature. During the period of 35 years, SLM had released nearly 800 articles about music. Majority of that number belongs to the music criticism, but there are also studies and essays about music ethno musicological treatises, polemics, obituary notices, as well as many ample and diverse notes. SLM was published during the time when Serbian society, culture and art were influenced by strong challenges of Europeanization and modernization. Therefore, one of the most complicated questions that music writers of this magazine were confronted with was the question of avant-garde music evaluation. Relation of critics and essay writers to the avant-garde was ambiguous. On one side, SLM's authors accepted modern art in principle, but, on the other side, they questioned that acceptance when facing even a bit radical music composition. This ambivalence as a whole marked the work of Dr Miloje Milojević, the leading music writer of SLM. It is not the same with other critics and essayists Kosta Manojlović was more tolerant, and Dragutin Čolić and Stanislav Vinaver were true protectors of the most avant-garde aspirations in music. First of all SLM was a literary magazine. In the light of that fact it has to be pointed out that very early, way back in 1912, critics wrote about Arnold Schoenberg, and that until the end of existence of this magazine the readers were regularly informed about all important avant-garde styles and composers of European, Serbian and Yugoslav music. The fact that Schoenberg Stravinsky, Honegger or Josip Slavenski mostly were not accepted by critics and essayists, expresses the basic aesthetic position of this magazine. Namely, SLM remained loyal to the moderate wing of modern music, music that had not rejected

  12. Reflections on Linguistic and Literary Colonization and Decolonization in Africa

    Directory of Open Access Journals (Sweden)

    Eric Sellin

    1991-01-01

    Full Text Available Despite the cultural diversity found in Africa and the complexity ofthe psychology of the colonizer and the colonized, several fundamental facts emerge regarding the function of language and literature in recent African history. The colonizer sought to instill a sense of inferiority in the colonized as part of the dynamics of conquest, placing special emphasis on education and language. These notions, lucidly discussed by such social thinkers as O. Mannoni, Frantz Fanon, and Albert Memmi, have analogues in the defense of language everywhere where lingua-political oppression occurs, be it in colonial Africa or on an Arapaho reservation in the American West. What is especially significant about the forced acquisition of a European language is the fact that this very tool of oppression tended to become the total of unity and rebellion for the oppressed. From a political viewpoint, the acquisition of a European lingua-franca entailed such logistics of liberation as communication and collective identity which overrode regional and tribal differences. From a cultural viewpoint, the language which had been used to colonize the minds of Africans knew two phases: first, one of simple acquisition of both language and attendant literary forms and second, one in which the European language was warped or "bullied" to fit the author's African cultural impulses. In the second instance we have, as a result of code-mixing and the transfer of cultural factors, the emergence of a unique and vigorous literature. In itself, this literature may be appreciated qua literature, but we should not forget that the code-mixing is often as concerned with the rejection of the language of oppression and the restauration of indigenous values as it is with traditional literary self-expression, as, for example, in the two poems by Algerian poet Youcef Sebti which bear the titles "La Soleil" and "Le Lune," thereby pooh-poohing sacrosanct French grammar by reversing the genders of

  13. Gadamer; Habermas and a Re-humanized Literary Scholarship

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    Roger D. Sell

    2006-06-01

    Full Text Available This paper speaks of an ongoing re-humanization of literary studies to which the work of Gadamer and Habermas can valuably contribute. True; these two thinkers themselves run the risk becoming the focus of commentaries that are aridly scholastic. True; too; they themselves tend to think of literature as an aesthetic heterocosm that is quite distinct from human communication in general. Yet human communication in general is something they certainly understand; and their profound insights into it can actually be applied to literature; in ways which they themselves have not envisaged. Especially relevant in Gadamer is his sense of the changes which can be brought about by communication; and his rehabilitation of common sense. In both Gadamer and Habermas; there is also a clear recognition of communicational dialogicality; and of communication’s sheer possibility; even between human beings who are very differently placed. To this can be added Habermas’s central insistence on ethical considerations – on human equality; on truthfulness; on trust; on fairness; on cooperativeness – as an integral dimension of communication at its most genuine. These insights can facilitate the discussion as illustrated with the writings of Dickens and T.S. Eliot.

  14. Literary Commitment in Bessie Head’s Maru

    Directory of Open Access Journals (Sweden)

    Elizabeth A. Odhiambo

    2013-07-01

    Full Text Available This was a study of Bessie Head’s literary commitment. The objective of the study was to interrogate the extent to which the writer is committed as a woman and as a Third World person based on the text Maru. The study adopted the analytical research design. The data collected through content analysis was coded according to thematic concerns, stylistic choices, the mode of characterization and vision of the author. The postcolonial theory was employed in the reading analysis and interpretation of the selected text. The findings reveal that as a woman, Bessie Head is committed to reconstructing a positive image for her female characters by challenging stereotypical perception of women through dismantling of patriarchal structures that previously relegated women to subordinate roles. This is seen in the presentation of the female characters as strong willed, determined, assertive, independent and enterprising. In delineating the experiences of women as women, she explores their most personal convictions thereby presenting their perception of issues as women. As a Third World writer, Head is committed to social justice, exposition of suffering and dehumanization resulting from ethnic prejudice and superstition. She voices for the voiceless by advocating gender equity as a basis for development. On the political arena, she examines issues that ail African politics such as selfish and greedy leadership, oppression and discrimination on basis of race. The text particularly dwells on the racial prejudices and class difference in the society. 

  15. A SEMIOSE DA FANTASIA LITERÁRIA Semiosis LITERARY FANTASY

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    JULIO JEHA

    2000-01-01

    Full Text Available A literatura refere-se tanto ao que existe na fisicalidade quanto ao que existeapenas como um construto da mente. Isso é possível por causa da naturezarelacional do signo e, portanto, da linguagem. A fantasia é vista pelas teoriasliterárias em geral como uma manifestação artística inferior. No entanto, a naturezaepistemológica e ontológica do signo literário implica que ambas as tendênciasem direção ao real e à fantasia são igualmente válidas, pois uma depende daoutra para existir.Literature can refer to what exists in the physicality and to what exists as a mindconstruct. This is possible because of the relational nature of the sign and,therefore, of language. Fantasy is seen by literary theories in general as aninferior artistic manifestation. However, the epistemological and ontologicalnature of the sign implies that both tendencies toward the real and the imaginaryare equally valid, for one depends on the other to exist.

  16. Head Transplants and Personal Identity: A Philosophical and Literary Survey.

    Science.gov (United States)

    Mori, Giuliano

    2016-04-01

    The criterion of personal identity is clearly called into question by the project to perform a human head transplant. Is identity provided by psychological continuity alone, or does it depend on bodily continuity as well? And how do these different perspectives interface with our notion of mind and mind-body relationship? The reader will be provided with a discussion concerning these problems, together with a philosophical and literary survey about the conception of body-mind relationship from the Greek thought to contemporary philosophy. The analysis will conclude with a discussion concerning the possibility to consider the issue of personal identity from a statistic point of view, which privileges the general perception of identity, so as it has been shaped by the cultural trends of the last four centuries. It could hence be argued that personal identity is not something which can be defined once and for all. On the contrary, the general perception of identity is subject to significant alterations resulting from one's cultural environment. However, the cultural environment itself can be changed by particularly notable events, such as, hypothetically, the successful outcome of a human head transplant. © 2016 John Wiley & Sons Ltd.

  17. DOSTOEVSKY'S RELIGIOSITY AS A METHODOLOGICAL PROBEM OF SOVIET LITERARY CRITICISM

    Directory of Open Access Journals (Sweden)

    Sergey Sergeevich Shaulov

    2012-11-01

    Full Text Available Soviet literary criticism, especially in the first decades after the 1917 Revolution, was quite biased in its treatment of Dostoevsky and his works. The reasons for this bias lie both inside and outside the sphere of political ideology. We suggest that there exists a genetic link between some Soviet readings of Dostoevsky and a number of interpretations made in the author's lifetime. Also analysed are the attempts to 'domesticate' Dostoevsky and adapt his works to drastically different cultural conditions and political norms. It is indicative that this adaptation has always passed the stage of mythologizing the writer and his works. This mythologization paradoxically became a convergence point for Soviet (Lunacharsky, anti-Soviet (Berdyayev and purely philosophical (Bakhtin readings of Dostoevsky. Ultimately, the central Dostoevsky myth in post-revolutionary Russia was a version of Romantic mythology often directly expressed in comparing Dostoevsky with Prometheus. We also look at the negative readings of Dostoevsky, which construed the author as a certain mythological antagonist of the proletariat as the collective messiah. Such readings (exemplified in our article by Pereverzev's and Livshits' point at the ultimate limit of ethical assessment of Dostoevsky from the standpoint of rational secular humanism and the Soviet humanitarian thought as its version. Dostoevsky's artistic practice incorporates this tradition within the intranovel dialogue as just one of the voices and demonstrates its ethical insufficiency, which in its turn provokes the mixed reaction of 'appropriation' and 'rejection' from both Soviet thinkers and their contemporary heirs.

  18. Literary Commitment in Bessie Head’s Maru

    Directory of Open Access Journals (Sweden)

    Elizabeth A. Odhiambo

    2013-07-01

    Full Text Available This was a study of Bessie Head’s literary commitment. The objective of the study was to interrogate the extent to which the writer is committed as a woman and as a Third World person based on the text Maru. The study adopted the analytical research design. The data collected through content analysis was coded according to thematic concerns, stylistic choices, the mode of characterization and vision of the author. The postcolonial theory was employed in the reading analysis and interpretation of the selected text. The findings reveal that as a woman, Bessie Head is committed to reconstructing a positive image for her female characters by challenging stereotypical perception of women through dismantling of patriarchal structures that previously relegated women to subordinate roles. This is seen in the presentation of the female characters as strong willed, determined, assertive, independent and enterprising. In delineating the experiences of women as women, she explores their most personal convictions thereby presenting their perception of issues as women. As a Third World writer, Head is committed to social justice, exposition of suffering and dehumanization resulting from ethnic prejudice and superstition. She voices for the voiceless by advocating gender equity as a basis for development. On the political arena, she examines issues that ail African politics such as selfish and greedy leadership, oppression and discrimination on basis of race. The text particularly dwells on the racial prejudices and class difference in the society.

  19. The literary uses of high-dimensional space

    Directory of Open Access Journals (Sweden)

    Ted Underwood

    2015-12-01

    Full Text Available Debates over “Big Data” shed more heat than light in the humanities, because the term ascribes new importance to statistical methods without explaining how those methods have changed. What we badly need instead is a conversation about the substantive innovations that have made statistical modeling useful for disciplines where, in the past, it truly wasn’t. These innovations are partly technical, but more fundamentally expressed in what Leo Breiman calls a new “culture” of statistical modeling. Where 20th-century methods often required humanists to squeeze our unstructured texts, sounds, or images into some special-purpose data model, new methods can handle unstructured evidence more directly by modeling it in a high-dimensional space. This opens a range of research opportunities that humanists have barely begun to discuss. To date, topic modeling has received most attention, but in the long run, supervised predictive models may be even more important. I sketch their potential by describing how Jordan Sellers and I have begun to model poetic distinction in the long 19th century—revealing an arc of gradual change much longer than received literary histories would lead us to expect.

  20. VISUAL OUTCOME FOLLOWING PANRETINAL PHOTOCOAGULATION IN PROLIFERATIVE DIABETIC RETINOPATHY

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    Nellaye Mani Sindhu

    2018-01-01

    Full Text Available BACKGROUND Diabetes mellitus can be called as a noninfectious pandemic and the incidence of diabetic retinopathy is also uncontrollable. This vision-threatening complication can be treated by early diagnosis and effective treatment like panretinal photocoagulation. The aim of the study is to evaluate the effect of panretinal photocoagulation on visual acuity, colour vision, contrast sensitivity and severity of visual field changes. MATERIALS AND METHODS Prospective study of visual outcome following panretinal photocoagulation in patients with proliferative diabetic retinopathy conducted in Retina Clinic, RIO, Trivandrum, during the time period one year from April 2008. Inclusion Criteria- Eyes with proliferative diabetic retinopathy, visual acuity better than or equal to 6/60, a follow up of at least 6 months after panretinal photocoagulation. Exclusion Criteria- Eyes with cataractous changes in the lens, eyes, which would be undergoing or have undergone focal photocoagulation eyes, which undergone barrage or sectoral retinal photocoagulation, patients with colour blindness, eyes with vitreous haemorrhage and macular preretinal haemorrhage, glaucomatous patients with peripheral field loss. RESULTS The mean age of the patients was 52 years. Male patients (30 outnumbered the female patients (23. Mean duration of diabetes was 14.42 years. Though, there is a statistically significant reduction in visual acuity in the first followup, which was improved and stabilised by 6 months. There is a statistically significant reduction in the contrast sensitivity, which was stabilised after 3 months. Only, 9.5% patients had peripheral constrictions of visual field and no significant change in the colour vision. CONCLUSION We recommend panretinal photocoagulation for all patients with proliferative diabetic retinopathy.

  1. Chronic proliferative synovitis of the equine metacarpophalangeal joint

    International Nuclear Information System (INIS)

    Kannegieter, N.J.

    1990-01-01

    Chronic proliferative synovitis of 27 metacarpophalangeal joints in 16 horses is described. The diagnosis was based on a history of lameness and, or, poor performance, pain on flexion of the metacarpophalangeal joint, the response to intra-articular anaesthesia, and plain and contrast radiography. Radiographic findings included concavity of the distal dorsal metacarpus proximal to the sagittal ridge, and an increase in size of the synovial tissue adjacent to the proximal, dorsal attachment of the joint capsule. Mineralisation of the synovial tissue was present in some joints, and chip fractures from the dorsal aspect of the proximal phalanx were also occasionally seen. Treatment by arthroscopic resection of the tissue gave excellent results

  2. Comments on 'Standard effective doses for proliferative tumours'

    International Nuclear Information System (INIS)

    Dasu, Iuliana Livia; Dasu, Alexandru; Denekamp, Juliana; Fowler, Jack F.

    2000-01-01

    We should like to make some comments on the paper published by Jones et al (1999). The paper presents some interesting and useful contributions on the theoretical evaluation of different fractionated schedules used now. The use of the linear quadratic equation has been very useful in focusing attention on the differences in fractionation responses of fast and slow proliferating normal tissues and tumours. Unfortunately the BED 10 or BED 3 units for (α/β ratios of 10 Gy and 3 Gy respectively) do not directly relate to anything used in routine clinical practice. The purpose of the paper by Jones et al (1999) is to covert any new schedule into the equivalent total dose as if it was given in the same size fractions as are in common use in that department. They illustrate that, if proliferation is taken into account for the altered schedule, it can be compared in two ways with the standard conventional schedule: (a) the proliferative standard effective dose one (PSED 1 ) in which the proliferation correction is applied in the altered schedule, but not in the standard schedule; (b) the proliferative standard effective dose two (PSED 2 ) in which the proliferation correction is applied to both schedules using the same proliferation parameters. This is expected to provide a better evaluation of the response of a 'real' tumour (i.e. a tumour that also proliferates during the standard treatment). However, there seem to be two errors in the paper. First, the authors quoted a wrong equation for calculating the proliferative standard effective dose two (PSED 2 ) (equations (2) and (A6) in their paper). There are also some special cases with respect to the time available for proliferation and the duration of the treatment that have been neglected in their paper and which require further specification. Therefore, we should like to give the full mathematical derivation of the correct equations for calculating the proliferative standard effective doses. We would also like to make

  3. ICT and Architectural Theory and History: from Literary Discourse to Design Paradigms?

    NARCIS (Netherlands)

    Proveniers, A.G.W.J.; Gelting, A.K.; Harder, E

    2008-01-01

    Design Studio Practice in the ICT— Google Era As a jury on Architectural projects we all recognise the unpleasant feeling when we hear a too highly polished student ICT-presentation: the plan does not correspond with the literary plea.

  4. Values and strategies of literary aesthetic appreciation in college English teaching in Chinese campuses

    OpenAIRE

    Wang, Wen; Guo, Yingjie

    2012-01-01

    Literary aesthetic appreciation is an indispensable part of college English teaching. As an important content of aesthetic education as well as one of the basic qualities of the compound-type foreign language learners, literary aesthetic appreciation is also an essential part of the college teaching innovation, curriculum construction and training objectives. In the course of students' acquiring aesthetic knowledge, college English teachers need to combine moral education and highlight the va...

  5. El pensament lingüístico-literari de Teodor Llorente

    Directory of Open Access Journals (Sweden)

    Vicent Salvador

    2015-11-01

    Full Text Available The literary-linguistic thought of the father of the Renaixença in Valencia (his conception of the socio­linguistic functions of Catalan, his vision of the unity of the language, his assessment of the various literary genre, etc. forms a coherent system and can be explained by class interests which brought the Renaixença and its modernizing perspectives to a halt in Valencia.

  6. Apoptotic and anti-proliferative effects of all-trans retinoic acid

    International Nuclear Information System (INIS)

    Zamora, Monica; Ortega, Juan Alberto; Alana, Lide; Vinas, Octavi; Mampel, Teresa

    2006-01-01

    We examined the apoptotic and anti-proliferative effects of all-trans retinoic acid (atRA) in HeLa cells. Our results demonstrated that HeLa cells were more sensitive to the anti-proliferative effects of atRA than to its apoptotic effects. Furthermore, we demonstrated that caspase inhibition attenuates cell death but does not alter the atRA-dependent reduction in cell proliferation, which suggests that atRA-induced apoptosis is independent of the arrest in cell proliferation. To check whether ANT proteins mediated these atRA effects, we transiently transfected cells with expression vectors encoding for individual ANT (adenine nucleotide translocase 1-3). Our results revealed that ANT1 and ANT3 over-expressing HeLa cells increased their atRA sensitivity. Thus, our results not only demonstrate the different functional activities of ANT isoforms, but also contribute to a better understanding of the properties of atRA as an anti-tumoral agent used in cancer therapy

  7. Arctigenin in combination with quercetin synergistically enhances the anti-proliferative effect in prostate cancer cells

    Science.gov (United States)

    Wang, Piwen; Phan, Tien; Gordon, David; Chung, Seyung; Henning, Susanne M.; Vadgama, Jaydutt V.

    2014-01-01

    Scope We investigated whether a combination of two promising chemopreventive agents arctigenin and quercetin increases the anti-carcinogenic potency at lower concentrations than necessary when used individually in prostate cancer. Methods and results Androgen-dependent LAPC-4 and LNCaP prostate cancer cells were treated with low doses of arctigenin and quercetin alone or in combination for 48h. The anti-proliferative activity of arctigenin was 10-20 fold stronger than quercetin in both cell lines. Their combination synergistically enhanced the anti-proliferative effect, with a stronger effect in androgen receptor (AR) wild-type LAPC-4 cells than in AR mutated LNCaP cells. Arctigenin demonstrated a strong ability to inhibit AR protein expression in LAPC-4 cells. The combination treatment significantly inhibited both AR and PI3K/Akt pathways compared to control. A protein array analysis revealed that the mixture targets multiple pathways particularly in LAPC-4 cells including Stat3 pathway. The mixture significantly inhibited the expression of several oncogenic microRNAs including miR-21, miR-19b, and miR-148a compared to control. The mixture also enhanced the inhibition of cell migration in both cell lines compared to individual compounds tested. Conclusion The combination of arctigenin and quercetin, that target similar pathways, at low physiological doses, provides a novel regimen with enhanced chemoprevention in prostate cancer. PMID:25380086

  8. Role of Stromal Paracrine Signals in Proliferative Diseases of the Aging Human Prostate

    Directory of Open Access Journals (Sweden)

    Kenichiro Ishii

    2018-04-01

    Full Text Available Androgens are essential for the development, differentiation, growth, and function of the prostate through epithelial–stromal interactions. However, androgen concentrations in the hypertrophic human prostate decrease significantly with age, suggesting an inverse correlation between androgen levels and proliferative diseases of the aging prostate. In elderly males, age- and/or androgen-related stromal remodeling is spontaneously induced, i.e., increased fibroblast and myofibroblast numbers, but decreased smooth muscle cell numbers in the prostatic stroma. These fibroblasts produce not only growth factors, cytokines, and extracellular matrix proteins, but also microRNAs as stromal paracrine signals that stimulate prostate epithelial cell proliferation. Surgical or chemical castration is the standard systemic therapy for patients with advanced prostate cancer. Androgen deprivation therapy induces temporary remission, but the majority of patients eventually progress to castration-resistant prostate cancer, which is associated with a high mortality rate. Androgen deprivation therapy-induced stromal remodeling may be involved in the development and progression of castration-resistant prostate cancer. In the tumor microenvironment, activated fibroblasts stimulating prostate cancer cell proliferation are called carcinoma-associated fibroblasts. In this review, we summarize the role of stromal paracrine signals in proliferative diseases of the aging human prostate and discuss the potential clinical applications of carcinoma-associated fibroblast-derived exosomal microRNAs as promising biomarkers.

  9. Analysis of the proliferative potential of odontogenic epithelial cells of pericoronal follicles.

    Science.gov (United States)

    Cimadon, Natalia; Lauxen, Isabel Silva; Carrard, Vinicius Coelho; Sant'Ana Filho, Manoel; Rados, Pantelis Varvaki; Oliveira, Márcia Gaiger

    2014-11-01

    To evaluate the proliferative potential and the cell proliferation rate of odontogenic epithelial cells. Forty-two cases of pericoronal follicles of impacted third molars were submitted to silver impregnation technique for quantification of argyrophilic nucleolar organizer regions (AgNOR) and immunohistochemical staining for EGFR and Ki-67. For AgNOR quantification, the mean number of active nucleolar organizer regions per nucleus (mAgNOR) and the percentage of cells with 1, 2, 3 and 4 or more AgNORs per nucleus (pAgNOR) were quantified. Ki-67 immunolabeling was quantified, whereas for EGFR, a descriptive analysis of staining patterns (membrane, cytoplasm or membrane + cytoplasm positivity) was performed. We evaluated the reduced epithelium of the enamel organ and/or islands of odontogenic epithelium present in the entire connective tissue. mAgNOR were 1.43 (1.0-2.42) and were significantly different among pericoronary follicles from upper and lower teeth (p = 0.041). Immunostaining of Ki-67 was negative in all cases. EGFR immunolabeling was found mainly in the cytoplasm and was more intense in islands and cords when compared to reduced epithelium of the enamel organ. Odontogenic epithelial cells of some pericoronal follicles have proliferative potential, suggesting their association with the development of odontogenic lesions. The authors suggest that nonerupted, especially of the lower teeth, should be monitored and if necessary removed.

  10. Reading Parallel Texts in the Target Language: A Way to Improve Literary Translation Quality

    Directory of Open Access Journals (Sweden)

    Nazanin Shadman

    2013-10-01

    Full Text Available The present study was an attempt to investigate the effect of reading Persian literary texts on the quality of literary translations. To this end, 52 students majoring in English translation were randomly assigned to two groups. A Comprehensive English Language Test (CELT was administered to check the homogeneity of the participants. The treatment for the experimental group consisted of reading 60 Persian short stories and poems. In the meantime, the control group went through their ordinary course curriculum. Both groups were asked to translate extracts of two short stories. The translations were then rated. Through statistical analysis, it was revealed that reading Persian literary works, indeed, improves the quality of literary translations. Therefore, to promote a more fruitful instruction on literary translation, it is suggested that translation teachers attempt to consider reading Persian literary works as part of the curriculum and ask students to read Persian texts to the extent possible, so that more qualified translations would be rendered in the area of literature.

  11. Stylistic Performance through Affective Marking: A Case of Multilingual Literary Discourse

    Directory of Open Access Journals (Sweden)

    Urjani Chakravarty

    2016-12-01

    Full Text Available This paper provides an overall analysis of how multi-lingual writer like Amitav Ghosh write about emotion in his literary text, and emphasize on how multilingual authors display emotion/affect through use of literary multilingualism (affective markers combined with writer style. Through use of multiple strategies, they reduces the limitations of interpretation of their texts. Furthermore, this paper highlighted the centrally sociolinguistic and cognitive dimensions of the relationships between multilingualism and emotion and how this is influenced by assumptions of Relevance Theory i.e. optimal relevance in a literary text. One should expect to find relationships between sociolinguistic diversity and affective expression for most authors in locally specific ways, whether multilingual or not. Such scholarship can then illuminate how the authors by using literary multilingualism through writer style and affective markers can shape emotions across various contexts in a literary text. Future research into multilingualism and emotion should continue to distinguish between how multilingual authors use linguistic forms to show feeling, and how they express about feeling in their created texts. Keywords: Language, Culture, Literary Multilingualism, Style, Affect and Relevance Theory

  12. Individual Differences in Sensitivity to Style During Literary Reading: Insights from Eye-Tracking

    Directory of Open Access Journals (Sweden)

    Emiel van den Hoven

    2016-12-01

    Full Text Available Style is an important aspect of literature, and stylistic deviations are sometimes labeled foregrounded, since their manner of expression deviates from the stylistic default. Russian Formalists have claimed that foregrounding increases processing demands and therefore causes slower reading – an effect called retardation. We tested this claim experimentally by having participants read short literary stories while measuring their eye movements. Our results confirm that readers indeed read slower and make more regressions towards foregrounded passages as compared to passages that are not foregrounded. A closer look, however, reveals significant individual differences in sensitivity to foregrounding. Some readers in fact do not slow down at all when reading foregrounded passages. The slowing down effect for literariness was related to a slowing down effect for high perplexity (unexpected words: those readers who slowed down more during literary passages also slowed down more during high perplexity words, even though no correlation between literariness and perplexity existed in the stories. We conclude that individual differences play a major role in processing of literary texts and argue for accounts of literary reading that focus on the interplay between reader and text.

  13. Proliferative and nonproliferative breast disease in atomic-bomb survivors

    International Nuclear Information System (INIS)

    Tokunaga, Masayoshi; Land, C.E.; Aoki, Yoichiro; Yamamoto, Tsutomu; Asano, Masahide; Sato, Eiichi; Tokuoka, Shoji; Sakamoto, Goi; Page, D.L.

    1993-10-01

    The risk of female breast cancer in association with radiation exposure is well established, on the basis of follow-up studies of the atomic-bomb survivors and other exposed populations. This association is especially strong for women exposed before age 20 yr and appears to be much weaker among women exposed after age 40 yr. In this study, breast-tissue autopsy samples from high-dose and low-dose individuals in the Radiation Effects Research Foundation Life Span Study sample were examined in detail to determine whether nonproliferative or proliferative breast lesions are associated with radiation exposure. The results suggest that proliferative disease in general and atypical hyperplasia in particular are associated with radiation exposure and that the risk is strongest for subjects who were ages 40-49 yr at the time of the bombings. It is hypothesized that this finding may be related to the age dependence of radiation-induced breast cancer, in the sense that potential cancers reflecting early-stage changes induced at these ages by radiation exposure may receive too little hormonal promotion to progress to frank cancers. (author)

  14. Neoplastic and proliferative disorders of the perinephric space

    International Nuclear Information System (INIS)

    Heller, M.T.; Haarer, K.A.; Thomas, E.; Thaete, F.L.

    2012-01-01

    The perinephric space is a well-marginated central compartment of the retroperitoneum, located between the anterior and posterior pararenal spaces. Various neoplastic and proliferative disorders can affect the perinephric space, and there is a wide array of imaging findings. Although many perinephric lesions may extend directly from the kidney and adrenal gland, other lesions occur in the perinephric space due to haematogenous spread, as part of a systemic disease, or by extension from an adjacent retroperitoneal compartment. Imaging plays a pivotal role in the diagnosis of perinephric diseases, as many of the disease processes affecting this space will not result in clinical signs or symptoms until the disease is at an advanced stage. Despite the often shared non-specific clinical and imaging findings among these disease processes, application of a categorical differential diagnosis based on the imaging characteristics will serve to narrow the differential diagnosis and direct further evaluation and treatment. In this article, the lesions have been categorized as soft-tissue rind [nephroblastomatosis, fibrosis, Erdheim–Chester disease (ECD), extramedullary haematopoiesis, lymphoma, infiltrating metastases], focal solid lesions (extension of renal or adrenal malignancies, melanoma metastases, treated lymphoma), fat-containing lesions (angiomyolipoma, liposarcoma, myelolipoma), and cystic lesions (lymphangiomas, abscesses). The aim of this article is to demonstrate and describe the key imaging features of several neoplastic and proliferative disorders that affect the perinephric space.

  15. Oral proliferative verrucous leukoplakia: A case report with an update

    Directory of Open Access Journals (Sweden)

    Rakhi Issrani

    2013-01-01

    Full Text Available White lesions both physiologic as well as pathologic are relatively frequent in the oral cavity, the most common pathology being oral leukoplakia (OL. There are many variants of OL, one of which is oral proliferative verrucous leukoplakia (OPVL. OPVL is a rare clinico-pathological entity, which is slow growing, long-term progressive lesion, but remains an enigmatic and difficult to define. The etiology of OPVL remains still unclear. Tobacco use does not seem to have a significant influence on the appearance of OPVL. These lesions may occur both in smokers and non-smokers. It is observed more frequently in women and elderly patients over 60 years at the time of diagnosis. The buccal mucosa and tongue are the most frequently involved sites. It develops initially as a white plaque of hyperkeratosis that eventually becomes a multifocal disease with confluent, exophytic and proliferative features. Various published case series have presented OPVL as a disease with aggressive biological behavior due to its high probability of recurrence and a high rate of malignant transformation. Prognosis is poor for this seemingly harmless-appearing white lesion of the oral mucosa. This article describes the clinical aspects and histologic features of an OPVL case that demonstrated the typical behavior pattern in a long-standing, persistent lesion and discusses this relatively rare entity in light of current information.

  16. Juvencus and the biblical epic: specificity and literary criticism

    Directory of Open Access Journals (Sweden)

    Elena María Calderón de Cuervo

    2015-04-01

    Full Text Available Latin Christian poetry has emerged in  Constantine Era and flourished between 400 and 800. It has a fundamental role in the development of literary theory and critical discourse, because, except for Prudencio, the rest of the poets of this first period has chosen by the adaptation of the classical canon to Christian themes. The Christian epic is therefore one of the first genres and begins as biblical epic. The first major work of this type is the Gospel Harmony from the Spanish poet Juvencus, until 330. This work begins a long series of biblical poetry, Latin at first, but after this there is its continuation in the vernaculars, like Caedmon, Cynewulf, The Heliand, The Passion by Clermont till Ojeda, Milton and Klopstock.The dedication to the established authority , the subordination of the art´s purpose for the salvation of the soul as well as the desire to legitimize poetry with Christian arguments remain as fundamental premises in the construction of gender. When the modern epic apear, its compromise with new theological Aporia will not lose those extraliterary requirements from provenance.Keywords: Latin Christian poetry; Constantine Era; Virgil.

  17. Atypical proliferative myositis: original MR description with pathologic correlation: Case report

    Energy Technology Data Exchange (ETDEWEB)

    Jarraya, Mohamed; Guermazi, Ali [Boston University School of Medicine, Department of Radiology, Musculoskeletal Section, Boston, MA (United States); Parva, Pedram [VA Boston Healthcare System, Boston, MA (United States); Stone, Michael [Stamford Hospital, Department of Surgery, Stamford, CT (United States); Klein, Michael J. [Hospital for Special Surgery, Department of Pathology and Laboratory Medicine, New York, NY (United States)

    2014-08-15

    Proliferative myositis (PM) along with proliferative fasciitis and nodular fasciitis are a group of pseudosarcomatous myofibroblastic proliferations. Although the histologic presentation of each is almost identical, the magnetic resonance imaging (MRI) appearance of proliferative myositis is closer to that of inflammatory myopathies. We report a case of PM in which the imaging and histologic features combine typical findings of PM with unusual imaging features, suggesting of reactive (or nodular) fasciitis. (orig.)

  18. Atypical proliferative myositis: original MR description with pathologic correlation: Case report

    International Nuclear Information System (INIS)

    Jarraya, Mohamed; Guermazi, Ali; Parva, Pedram; Stone, Michael; Klein, Michael J.

    2014-01-01

    Proliferative myositis (PM) along with proliferative fasciitis and nodular fasciitis are a group of pseudosarcomatous myofibroblastic proliferations. Although the histologic presentation of each is almost identical, the magnetic resonance imaging (MRI) appearance of proliferative myositis is closer to that of inflammatory myopathies. We report a case of PM in which the imaging and histologic features combine typical findings of PM with unusual imaging features, suggesting of reactive (or nodular) fasciitis. (orig.)

  19. T-cell proliferative responses following sepsis in neonatal rats.

    Science.gov (United States)

    Dallal, Ousama; Ravindranath, Thyyar M; Choudhry, Mashkoor A; Kohn, Annamarie; Muraskas, Jonathan K; Namak, Shahla Y; Alattar, Mohammad H; Sayeed, Mohammed M

    2003-01-01

    Both experimental and clinical evidence suggest a suppression of T-cell function in burn and sepsis. The objective of the present study was to evaluate splenocyte and purified T-cell proliferative response and IL-2 production in septic neonatal rats. We also examined if alterations in T-cell proliferation and IL-2 production in neonatal sepsis is due to elevation in PGE2. PGE2 is known to play a significant role in T-cell suppression during sepsis in adults. Sepsis was induced in 15-day-old neonatal Sprague-Dawley rats by implanting 0.1 cm3 of fecal pellet impregnated with Escherichia coli (50 CFU) and Bacteroides fragilis (10(3) CFU). Animals receiving fecal pellets without the bacteria were designated as sterile. A group of septic and sterile rats were treated with PGE2 synthesis inhibitors, NS398 and resveratrol. These treatments of animals allowed us to evaluate the role of PGE2 in T-cell suppression during neonatal sepsis. Splenocytes as well as purified T cells were prepared and then proliferative response and IL-2 productive capacities were measured. A significant suppression of splenocyte proliferation and IL-2 production was noticed in both sterile and septic animals compared to the T cells from unoperated control rats. In contrast, the proliferation and IL-2 production by nylon wool purified T cells in sterile rats was not significantly different from control rats, whereas, a significant suppression in Con A-mediated T-cell proliferation and IL-2 production noticed in septic rat T cells compared to the sterile and control rat T cells. Such decrease in T-cell proliferation and IL-2 production was accompanied with 20-25% deaths in neonates implanted with septic pellets. No mortality was noted in sterile-implanted neonates. Treatment of animals with COX-1 inhibitor had no effect on T-cell proliferation response in both septic and sterile groups, whereas COX-2 inhibitor abrogated the decrease in T-cell proliferative response in the septic group. The treatment

  20. A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling

    NARCIS (Netherlands)

    Shvarts, Avi; Brummelkamp, Thijn R.; Scheeren, Ferenc; Koh, Eugene; Daley, George Q.; Spits, Hergen; Bernards, René

    2002-01-01

    Senescence limits the proliferative capacity of primary cells in culture. We describe here a genetic screen to identify genes that allow bypass of this checkpoint. Using retroviral cDNA expression libraries, we identify BCL6 as a potent inhibitor of senescence. BCL6 is frequently activated in

  1. A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19ARF-p53 signaling

    NARCIS (Netherlands)

    Shvarts, A.; Brummelkamp, T.; Koh, E.; Daley, G.Q.; Bernards, R.A.

    2002-01-01

    Senescence limits the proliferative capacity of primary cells in culture. We describe here a genetic screen to identify genes that allow bypass of this checkpoint. Using retroviral cDNA expression libraries, we identify BCL6 as a potent inhibitor of senescence. BCL6 is frequently activated in

  2. Analysis and Enhancements of a Prolific Macroscopic Model of Epilepsy

    Directory of Open Access Journals (Sweden)

    Christopher Fietkiewicz

    2016-01-01

    Full Text Available Macroscopic models of epilepsy can deliver surprisingly realistic EEG simulations. In the present study, a prolific series of models is evaluated with regard to theoretical and computational concerns, and enhancements are developed. Specifically, we analyze three aspects of the models: (1 Using dynamical systems analysis, we demonstrate and explain the presence of direct current potentials in the simulated EEG that were previously undocumented. (2 We explain how the system was not ideally formulated for numerical integration of stochastic differential equations. A reformulated system is developed to support proper methodology. (3 We explain an unreported contradiction in the published model specification regarding the use of a mathematical reduction method. We then use the method to reduce the number of equations and further improve the computational efficiency. The intent of our critique is to enhance the evolution of macroscopic modeling of epilepsy and assist others who wish to explore this exciting class of models further.

  3. Anticardiolipin antibodies in proliferative diabetic retinopathy: An additional risk factor

    International Nuclear Information System (INIS)

    Shahin, Maha; ElDiasty, Amany M; Mabed, Mohamed

    2009-01-01

    To report the prevalence of anticardiolipin antibodies in patients with proliferative diabetic retinopathy (PDR) having high-risk criteria (HRC). Diabetic patients having PDR with HRC and diabetics free of retinopathy were compared for the presence of anticardiolipin antibodies. Among the 34 patients, 6 (17.7%) of diabetics having PDR with HRC were positive for anticardiolipin antibodies. There was no significant association of aCL antibodies with sex or type of diabetes. Using Pearson's correlation test, no significant associations of aCL antibodies with duration of diabetes or age of patients were found. All patients who were positive for anticardiolipin antibodies had PDR with HRC. The difference was statistically significant. Presence of anticardiolipin antibodies may represent an additional risk factor for PDR. (author)

  4. Accounting for treatment delays when treating highly proliferative tumours

    International Nuclear Information System (INIS)

    Jones, L.; Metcalfe, P.; Hoban, P.

    1999-01-01

    This study was undertaken to investigate the possibility of increasing the dose per fraction or increasing the number of fractions to account for treatment delays occurring during radiotherapy treatments for highly proliferative tumours. The linear quadratic model with time was used to determine the difference in biological effective dose (BED) for the original schedule and the schedule including a treatment delay. Tables of extra fractions and extra dose per fraction required to account for a number of possible delays have been determined. It has been shown that for tumours with very short potential doubling times it is best to deliver the extra dose as an increase in dose per fraction rather than an increase in the number of fractions, while for tumours with moderately short potential doubling times (above 7 days) the reverse is true. The equivalent uninterrupted schedules, which would have delivered the same effects to the tumour, have also been determined. (author)

  5. Inheritance of proliferative breast disease in breast cancer kindreds

    International Nuclear Information System (INIS)

    Skolnick, M.H.; Cannon-Albright, L.A.; Goldgar, D.E.; Ward, J.H.; Marshall, C.J.; Schumann, G.B.; Hogle, H.; McWhorter, W.P.; Wright, E.C.; Tran, T.D.; Bishop, D.T.; Kushner, J.P.; Eyre, H.J.

    1990-01-01

    Previous studies have emphasized that genetic susceptibility to breast cancer is rare and is expressed primarily as premenopausal breast cancer, bilateral breast cancer, or both. Proliferative breast disease (PBD) is a significant risk factor for the development of breast cancer and appears to be a precursor lesion. PBD and breast cancer were studied in 103 women from 20 kindreds that were selected for the presence of two first degree relatives with breast cancer and in 31 control women. Physical examination, screening mammography, and four-quadrant fine-needle breast aspirates were performed. Cytologic analysis of breast aspirates revealed PBD in 35% of clinically normal female first degree relatives of breast cancer cases and in 13% of controls. Genetic analysis suggests that genetic susceptibility causes both PBD and breast cancer in these kindreds. This study supports the hypothesis that this susceptibility is responsible for a considerable portion of breast cancer, including unilateral and postmenopausal breast cancer

  6. Anti-Myeloperoxidase Antibodies Associate with Future Proliferative Lupus Nephritis

    Directory of Open Access Journals (Sweden)

    S. W. Olson

    2017-01-01

    Full Text Available Background. The subclinical pathophysiology of proliferative lupus nephritis (PLN has not been fully elucidated. Myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA is associated with PLN, but prediagnostic levels have not been reported. Methods. We performed a retrospective case-control Department of Defense Serum Repository (DoDSR study comparing MPO-ANCA levels in longitudinal prediagnostic serum samples for 23 biopsy confirmed proliferative lupus nephritis (PLN patients to DoDSR identified age, sex, race, and age of serum matched healthy and SLE without LN disease controls. We also compared the temporal relationship of MPO-ANCA to anti-double stranded DNA antibodies (dsDNAab. Results. A greater proportion of PLN patients had prediagnostic MPO-ANCA levels above ≥3 U/mL and ≥6 U/mL compared to SLE without LN (91% versus 43%, p<0.001; 57% versus 5%, p<0.001, resp.. In subgroup analysis, the MPO-ANCA threshold of ≥3 U/mL was significant at <1 year (88% versus 39%, p=0.007 and 1–4 years (87% versus 38%, p=0.009 prior to diagnosis. Statistically significant subclinical MPO-ANCA levels (≥3 U/mL occurred prior to statistically significant dsDNAab ≥ 3 IU/ml (89% versus 11%, p=0.003. Conclusions. Subclinical MPO-ANCA levels could distinguish future PLN from SLE without LN. MPO-ANCA manifests prior to clinical disease and subclinical dsDNAab to suggest that it may contribute directly to PLN pathogenicity.

  7. Arabella’s Valentines and Literary Connections [dot] com: Playing with Eighteenth-Century Gender Online

    Directory of Open Access Journals (Sweden)

    Melanie Holm

    2017-06-01

    Full Text Available This article describes two digital assignments that ask students to imaginatively embody characters from eighteenth-century texts written by women in order to cultivate a greater awareness of the critical role of gender and gender critique in these works. The first of these assignments, “Arabella’s Valentines,” asks students to translate dialogue from Charlotte Lennox’s The Female Quixote as humorous Internet memes. The second assignment, “Literary Connections [dot] com,” asks students to imagine how characters from the course archive might represent themselves on an internet dating site. Through creative role-play facilitated by these digital genres, students engage with the texts in stimulating and playful ways that extends their consideration of writers’ works beyond the page. In the article I explain how these activities were deployed using PowerPoint and Tumblr, and for the second assignment, Google Forms, with step-by-step instructions for replicating the technological aspects of the assignments, and add reflections on the outcome of these assignments for student learning.

  8. Temporal changes in retinal vascular parameters associated with successful panretinal photocoagulation in proliferative diabetic retinopathy

    DEFF Research Database (Denmark)

    Torp, Thomas Lee; Kawasaki, Ryo; Wong, Tien Yin

    2018-01-01

    PURPOSE: We aimed to investigate changes in retinal vascular geometry over time after panretinal photocoagulation (PRP) in patients with proliferative diabetic retinopathy (PDR). METHODS: Thirty-seven eyes with PDR were included. Wide-field fluorescein angiography (Optomap, Optos PLC., Dunfermline......, Scotland, UK) was used to diagnose PDR at baseline and to assess activity at follow-up month three and six. At each time-point, a trained grader measured retinal vessel geometry on optic disc (OD) centred images using semiautomated software (SIVA, Singapore I Vessel Assessment, National University...... of Singapore, Singapore) according to a standardized protocol. RESULTS: At baseline, the mean age and duration of diabetes were 52.8 and 22.3 years, and 65% were male. Mean HbA1c was 69.9 mmol/mol, and blood pressure was 155/84 mmHg. Of the 37 eyes with PDR, eight (22%) eyes had progression at month three...

  9. Critical Thinking Skills to Literary Works: A Method of Teaching Language through Literature

    Directory of Open Access Journals (Sweden)

    Fithriyah Inda Nur Abida

    2016-05-01

    Full Text Available Teaching a language has become a challenging task for the teachers to train and to teach language for their students. In present time, the ability to master a language is vital for a language is a powerful means of  communicating. Most of us will not focus on the language present in the literature part because our mind sets only towards the grammar. This has made both the teacher and students to ignore the literature part and made them to focus only on grammatical part to learn language. The urge behind using literary works in the teaching a language is to argue that the current attempts to implant literary works to the teaching of a language definitely develop students’ critical thinking in such a way that help them to easily master a particular language. Learning literary works in a classroom not only make the students learn about a story but also study how the language are structured and how its structured bring a great difference in meaning. Through a literary works student sees the language of real-life contexts. They learn the feelings, ideas, and experiences of linguistics components that give a realistic touch and help them to learn a language in a comprehensive way. It is also found that using literary works in the teaching learning process can improve student’s ability both in micro-linguistics and macro-linguistics.

  10. REVIEW: ORAL AND LITERARY CONTINUITIES IN MODERN TIBETAN LITERATURE: THE INESCAPABLE NATION

    Directory of Open Access Journals (Sweden)

    Reviewed by Séagh Kehoe

    2018-05-01

    Full Text Available Oral and Literary Continuities in Modern Tibet: The Inescapable Nation, Lama Jabb's contribution to Studies in Modern Tibetan Culture series, is the first book-length study in English to center the literary, cultural, and political roots of modern Tibetan literature. Written by Lama Jabb, born and raised in a herding community in Amdo and now a junior research fellow in Tibetan and Himalayan Studies at the University of Oxford, this ambitious landmark study offers an in-depth and meticulously researched examination of the persistence of Tibet's artistic and oral traditions in the literary creativity of the present. Spanning a wide-range of oral and literary texts, the book also draws attention to the deep and untiring concern for the Tibetan nation across modern Tibetan writing. The book is neatly organized into seven chapters, along with acknowledgements, an extensive bibliography, index, and short biography of Lama Jabb himself. In 277 pages, it moves gracefully across a diverse and skillfully interwoven set of discussions of Tibetan music, the Tibetan tradition of social criticism, cultural traumas, the Third Generation of Tibetan poets, and contemporary Tibetan erotic poetry, all the while spotlighting literary legacies and the persistent preoccupation for with the Tibetan nation in modern Tibetan literature. ...

  11. Orna Me: Laurence Sterne’s Open Letter to Literary History

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    Celia B. Barnes

    2016-12-01

    Full Text Available This essay considers the curious way Laurence Sterne communicates with and reflects on his literary predecessors, most often Alexander Pope, by writing love letters to women. Focusing primarily on his correspondence with Elizabeth Draper, Barnes contends that, even as Sterne looks back to Pope to guarantee himself a place in literary history, he looks forward to women like Draper to ensure his name will survive.  Thus, erotic correspondence becomes an important way of ensuring Sterne’s literary estate, or as he terms it, his “futurity.” “Orna Me”—a phrase that means, roughly, “ornament me” or “set me off,” and that Sterne got from Pope and Swift, who got it from Cicero—allows Sterne to plug in to a literary tradition that privileges collaboration: append something of yours to something of mine. It is this idea of letter-writing as correspondence, a collaborative process between friends or lovers, that unites Sterne to his female correspondent and to literary tradition all at once.

  12. Poetry in Transmedial Perspective: Rethinking Intermedial Literary Studies in the Digital Age

    Directory of Open Access Journals (Sweden)

    Schaefer Heike

    2015-08-01

    Full Text Available In the digital age. literary practice proliferates across different media platforms. Contemporary literary texts are written, circulated and rea|d in a variety of media, ranging from traditional print formats to online environments. This essay explores the implications that the transmedial dispersal of literary culture has for intermedial literary studies. If literature no longer functions as a unified single medium (if it ever did but unfolds in a multiplicity of media, concepts central to intermediality studies, such as media specificity, media boundaries and media change, have to be reconsidered. Taking as its test case the adaptation of E. E. Cummings’s experimental poetry in Alison Clifford’s new media artwork The Sweet Old Etcetera as well as in YouTube clips, the essay argues for a reconceptualization of contemporary literature as a transmedial configuration or network. Rather than think of literature as a single self-contained medium that engages in intermedial exchange and competition with other media, such as film or music, we can better understand how literature operates and develops in the digital age if we recognize the medial heterogeneity and transmedial distribution of literary practice.

  13. Isoliquiritigenin exhibits anti-proliferative properties in the pituitary independent of estrogen receptor function

    International Nuclear Information System (INIS)

    Weis, Karen E.; Raetzman, Lori T.

    2016-01-01

    The plant flavonoid isoliquiritigenin (ISL) is a botanical estrogen widely taken as an herbal supplement to ease the symptoms of menopause. ISL has been also shown to have anti-tumor properties in a number of cancer cell backgrounds. However, the effects of ISL on normal cells are less well known and virtually unstudied in the context of the pituitary gland. We have established a pituitary explant culture model to screen chemical agents for gene expression changes within the pituitary gland during a period of active proliferation and differentiation. Using this whole-organ culture system we found ISL to be weakly estrogenic based on its ability to induce Cckar mRNA expression, an estrogen receptor (ER) mediated gene. Using a range of ISL from 200 nM to 200 μM, we discovered that ISL promoted cell proliferation at a low concentration, yet potently inhibited proliferation at the highest concentration. ICI 182,780 failed to antagonize ISL's repression of pituitary cell proliferation, indicating the effect is independent of ER signaling. Coincident with a decrease in proliferating cells, we observed down-regulation of transcript for cyclin D2 and E2 and a strong induction of mRNA and protein for the cyclin dependent kinase inhibitor Cdkn1a (p21). Importantly, high dose ISL did not alter the balance of progenitor vs. differentiated cell types within the pituitary explants and they seemed otherwise healthy; however, TUNEL staining revealed an increase in apoptotic cell death in ISL treated cultures. Our results merit further examination of ISL as an anti-tumor agent in the pituitary gland. - Highlights: • Isoliquiritigenin possesses weak estrogenic activity based on induction of Cckar. • ISL can be anti-proliferative in pituitary explants without altering cell lineages. • Anti-proliferative behavior of ISL is not estrogen receptor mediated. • ISL induces p21 expression leading to cell cycle arrest and apoptosis.

  14. Isoliquiritigenin exhibits anti-proliferative properties in the pituitary independent of estrogen receptor function

    Energy Technology Data Exchange (ETDEWEB)

    Weis, Karen E.; Raetzman, Lori T., E-mail: raetzman@life.illinois.edu

    2016-12-15

    The plant flavonoid isoliquiritigenin (ISL) is a botanical estrogen widely taken as an herbal supplement to ease the symptoms of menopause. ISL has been also shown to have anti-tumor properties in a number of cancer cell backgrounds. However, the effects of ISL on normal cells are less well known and virtually unstudied in the context of the pituitary gland. We have established a pituitary explant culture model to screen chemical agents for gene expression changes within the pituitary gland during a period of active proliferation and differentiation. Using this whole-organ culture system we found ISL to be weakly estrogenic based on its ability to induce Cckar mRNA expression, an estrogen receptor (ER) mediated gene. Using a range of ISL from 200 nM to 200 μM, we discovered that ISL promoted cell proliferation at a low concentration, yet potently inhibited proliferation at the highest concentration. ICI 182,780 failed to antagonize ISL's repression of pituitary cell proliferation, indicating the effect is independent of ER signaling. Coincident with a decrease in proliferating cells, we observed down-regulation of transcript for cyclin D2 and E2 and a strong induction of mRNA and protein for the cyclin dependent kinase inhibitor Cdkn1a (p21). Importantly, high dose ISL did not alter the balance of progenitor vs. differentiated cell types within the pituitary explants and they seemed otherwise healthy; however, TUNEL staining revealed an increase in apoptotic cell death in ISL treated cultures. Our results merit further examination of ISL as an anti-tumor agent in the pituitary gland. - Highlights: • Isoliquiritigenin possesses weak estrogenic activity based on induction of Cckar. • ISL can be anti-proliferative in pituitary explants without altering cell lineages. • Anti-proliferative behavior of ISL is not estrogen receptor mediated. • ISL induces p21 expression leading to cell cycle arrest and apoptosis.

  15. Heme oxygenase is not involved in the anti-proliferative effects of statins on pancreatic cancer cells

    International Nuclear Information System (INIS)

    Vanova, K.; Boukalova, S.; Gbelcova, H.; Muchova, L.; Neuzil, J.; Gurlich, R.; Ruml, T.; Vitek, L.

    2016-01-01

    Pancreatic cancer is recognized as one of the most fatal tumors due to its aggressiveness and resistance to therapy. Statins were previously shown to inhibit the proliferation of cancer cells via various signaling pathways. In healthy tissues, statins activate the heme oxygenase pathway, nevertheless the role of heme oxygenase in pancreatic cancer is still controversial. The aim of this study was to evaluate, whether anti-proliferative effects of statins in pancreatic cancer cells are mediated via the heme oxygenase pathway. In vitro effects of various statins and hemin, a heme oxygenase inducer, on cell proliferation were evaluated in PA-TU-8902, MiaPaCa-2 and BxPC-3 human pancreatic cancer cell lines. The effect of statins on heme oxygenase activity was assessed and heme oxygenase-silenced cells were used for pancreatic cancer cell proliferation studies. Cell death rate and reactive oxygen species production were measured in PA-TU-8902 cells, followed by evaluation of the effect of cerivastatin on GFP-K-Ras trafficking and expression of markers of invasiveness, osteopontin (SPP1) and SOX2. While simvastatin and cerivastatin displayed major anti-proliferative properties in all cell lines tested, pravastatin did not affect the cell growth at all. Strong anti-proliferative effect was observed also for hemin. Co-treatment of cerivastatin and hemin increased anti-proliferative potential of these agents, via increased production of reactive oxygen species and cell death compared to individual treatment. Heme oxygenase silencing did not prevent pancreatic cancer cells from the tumor-suppressive effect of cerivastatin or hemin. Cerivastatin, but not pravastatin, protected Ras protein from trafficking to the cell membrane and significantly reduced expressions of SPP1 (p < 0.05) and SOX2 (p < 0.01). Anti-proliferative effects of statins and hemin on human pancreatic cancer cell lines do not seem to be related to the heme oxygenase pathway. While hemin triggers reactive

  16. Fibrinolysis and proliferative endarteritis: two related processes in chronic infections? The model of the blood-borne pathogen Dirofilaria immitis.

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    Javier González-Miguel

    Full Text Available The interaction between blood-borne pathogens and fibrinolysis is one of the most important mechanisms that mediate invasion and the establishment of infectious agents in their hosts. However, overproduction of plasmin (final product of the route has been related in other contexts to proliferation and migration of the arterial wall cells and degradation of the extracellular matrix. We have recently identified fibrinolysis-activating antigens from Dirofilaria immitis, a blood-borne parasite whose key pathological event (proliferative endarteritis is produced by similar mechanisms to those indicated above. The objective of this work is to study how two of this antigens [actin (ACT and fructose-bisphosphate aldolase (FBAL] highly conserved in pathogens, activate fibrinolysis and to establish a relationship between this activation and the development of proliferative endarteritis during cardiopulmonary dirofilariasis. We demonstrate that both proteins bind plasminogen, enhance plasmin generation, stimulate the expression of the fibrinolytic activators tPA and uPA in endothelial cell cultures and are located on the surface of the worm in contact with the host's blood. ELISA, western blot and immunofluorescence techniques were employed for this purpose. Additionally, the implication of lysine residues in this interaction was analyzed by bioinformatics. The involvement of plasmin generated by the ACT/FBAL and plasminogen binding in cell proliferation and migration, and degradation of the extracellular matrix were shown in an "in vitro" model of endothelial and smooth muscle cells in culture. The obtained results indicate that ACT and FBAL from D. immitis activate fibrinolysis, which could be used by the parasite like a survival mechanism to avoid the clot formation. However, long-term overproduction of plasmin can trigger pathological events similar to those described in the emergence of proliferative endarteritis. Due to the high degree of

  17. The Role of MKP-1 in the Anti-Proliferative Effects of Glucocorticoids in Primary Rat Pre-Osteoblasts.

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    Micheline Sanderson

    Full Text Available Glucocorticoid (GC-induced osteoporosis has been attributed to a GC-induced suppression of pre-osteoblast proliferation. Our previous work identified a critical role for mitogen-activated protein kinase (MAPK phosphatase-1 (MKP-1 in mediating the anti-proliferative effects of GCs in immortalized pre-osteoblasts, but we subsequently found that MKP-1 null mice were not protected against the pathological effects of GCs on bone. In order to reconcile this discrepancy, we have assessed the effects of GCs on proliferation, activation of the MAPK ERK1/2 and MKP-1 expression in primary adipose-derived stromal cells (ADSCs and ADSC-derived pre-osteoblasts (ADSC-OBs. ADSCs were isolated by means of collagenase digestion from adipose tissue biopsies harvested from adult male Wistar rats. ADSC-OBs were prepared by treating ADSCs with osteoblast differentiation media for 7 days. The effects of increasing concentrations of the GC dexamethasone on basal and mitogen-stimulated cell proliferation were quantified by tritiated thymidine incorporation. ERK1/2 activity was measured by Western blotting, while MKP-1 expression was quantified on both RNA and protein levels, using semi-quantitative real-time PCR and Western blotting, respectively. GCs were strongly anti-proliferative in both naïve ADSCs and ADSC-OBs, but had very little effect on mitogen-induced ERK1/2 activation and did not upregulate MKP-1 protein expression. These findings suggest that the anti-proliferative effects of GCs in primary ADSCs and ADSC-OBs in vitro do not require the inhibition of ERK1/2 activation by MKP-1, which is consistent with our in vivo findings in MKP-1 null mice.

  18. (58 Indices, Metaphors and Montages. The Heterogeneous Work in Current Latin American Literary Studies

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    Francisco Gelman Constantin

    2017-09-01

    Full Text Available As contemporary literary scholars challenge the ruling exclusionary criteria for the homogenization of their objects, while at the same time the biopolitical turn on literary theory criticizes representational understandings of the bond between language and the body, this paper suggests to address said relationship with recourse to the Lacanian notion of the ‘montage of heterogeneous’, which was brought forth toward a redefinition of the psychoanalytical concept of drive. Drawing from the notion of ‘heterogeneous literatures’, I advocate a theoretical genealogy from Bataille to Lacan (while Nancy, Foucault and Butler are also summoned to the discussion in order to come to terms with the rethinking of the objects for literary scholarship demanded by works such as Emilio García Wehbi’s performance piece 58 indicios sobre el cuerpo, along with his and Nora Lezano’s poetical- photographical essay Communitas.

  19. Literary Genres in Social Life: A Narrative, Audio-visual and Poetic Approach

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    Luis Felipe González Gutiérrez

    2008-05-01

    Full Text Available The proposal, "Literary Genres in Social Life: a Narrative, Audio-visual and Poetic Approach", attempts, by objective, to present/display to the academic psychology community and compatible social science disciplines the main contributions of literary genre theory through a social constructionist understanding of narrations and daily stories, and by means of an interactive construction of narrative collage. This work, sustained by an investigation financed by the University Santo Tomás in Bogota, Colombia, "Understanding of structuralist literary theories in the development of the narrative 'I' within the social constructionist approach", tries to propose alternative spaces for the presentation of its investigative results through the expression of metaphors, visual narrative sequences and interactive artistic forms, which invite the spectator to share in and to include/understand important concepts in the consolidation of social forms of construction of the quotidian. URN: urn:nbn:de:0114-fqs0802373

  20. The Literary Language of Cervantes El comedido hidalgo by Eslava Galán

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    Juan Miguel Monterrubio Prieto

    2016-11-01

    Full Text Available The aim of this work is to study in what way Eslava incorporates into “El Comedido Hidalgo” the literary techniques of Cervantes. It has been pointed out that Cervantes created, in some passages, an archaic language with a medieval appearance. Eslava, on the other hand, makes up a new language; new because it is not an accurate reproduction of the XVI and XVII centuries spoken language. This work shows how the novel fits a great amount of literary resources of Cervantes but in a different and new way. It is not about an exact copy of Cervantes´s literary techniques, but a hyperbole, sometimes transgressive, of these techniques. It is also a support of a critical, ironical and burlesque view of the Spanish Golden Era.

  1. Tragedy and the sovereignty of God: Christian literary criticism and the concept of tragedy

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    I. Haarhoff

    1979-03-01

    Full Text Available A Christian approach to literature is easily confused with a theological approach. There are many dangers implicit in such an approach. Sallie McFague TeSelle says the following about theologians who presume to violate the bounds of both theology and literature by attempting literary criticism: “There is no reason to suppose that those trained in theology, or philosophy for that matter, are likely to possess, what is essential to the practice of literary criticism, that ‘sensitiveness of the intelligence’ described by Matthew Arnold as equivalent to conscience in moral matters. A theological training seems to have a disabling effect and has subsequently to be struggled against when literary criticism is the concern.” (TeSelle 1966:4.

  2. Annotation of toponyms in TEI digital literary editions and linking to the web of data

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    Frontini, Francesca

    2016-07-01

    Full Text Available This paper aims to discuss the challenges and benefits of the annotation of place names in literary texts and literary criticism. We shall first highlight the problems of encoding spatial information in digital editions using the TEI format by means of two manual annotation experiments and the discussion of various cases. This will lead to the question of how to use existing semantic web resources to complement and enrich toponym mark-up, in particular to provide mentions with precise georeferencing. Finally the automatic annotation of a large corpus will show the potential of visualizing places from texts, by illustrating an analysis of the evolution of literary life from the spatial and geographical point of view.

  3. “Pajaritas de papel” by Jaime Campmany: a contribution to Spanish literary journalism

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    Antonio Fernández Jiménez

    2017-05-01

    Full Text Available The purpose of this article is to give the reader an overview of Jaime Campmany’s early career as a columnist who wrote literary articles he called ‘Pajaritas de papel’ (folded papers birds, which were published daily in the newspaper Arriba from 1966 to 1970. Due to the excellent quality of his literary writings within the framework of a new type of journalism being developed at the time, ‘Pajaritas de papel’ made a clear contribution to the study of literary journalism near the end of the post-war period in Spain due to his ability to reveal information in his articles at a time when the press was still suffering the impediment of censorship. For that reason and more, we consider his articles to have set a valuable precedent for the exalted status that opinion columns achieved in the decades that followed.

  4. USING AUTHENTIC LITERARY WORKS FOR THE FORMATION OF LEXICAL COMPETENCE OF FUTURE GERMAN LANGUAGE TEACHERS

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    Антоніна Палецька-Юкало

    2014-10-01

    Full Text Available The article deals with the advantages of use of authentic literary works as the main sphere of learning and improvement of foreign language vocabulary.The definition of lexical competence has been suggested. The possibilities for perceiving and analysis of such language phenomena as synonyms, antonyms, polisemic words, lexical links, linguistic clichés non-equivalent and emotionally colored vocabulary of authentic literary works as the basis of the formation of German lexical competence of future teachers have been grounded. The process of investigation has revealed that lexical contents of authentic literary works contribute to a comprehensive dictionary and learning connected speech structures, provide frequent repetition of lexical items, and create a sense of language.

  5. The Inter-Semiotic Negotiation between the Literary and the Cinematographic Image

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    Carmen DOMINTE

    2015-07-01

    Full Text Available Considering the postmodern perspective, a text or a discourse never ends, but continues in other texts and discourses. Besides the physical limits, any literary text or discourse develops in a literary system of references belonging to other texts or discourses. The concept of inter-semiotic negotiation describes the process of inter-action realized between two semiotic systems and shows that the meaning generated from one system can be transposed into another semiotic system and, even more, from the writer to the reader, and even further, from the director to the spectator, but mediated through different types of codes. Transferring the aesthetic meaning from one form of art (literature to another (cinematography, there are specific changes for the artistic manner of performance and reception but the common element that may link both arts is represented by the image: literary and cinematographic.

  6. The evolution of conceptions about space and time in literary theory

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    Lazić Nebojša J.

    2012-01-01

    Full Text Available This work considers the function of space and time in poetics of literary text from the antique period till the theory of deconstruction as well as from Aristotle till Jacques Derrida and Paul de Man. The science of literature did not equally treat the problem of space and the problem of time as the elements of the literary work's structure. Disbalance presents the damage of studying the space because there is a significant number of monographs about time. Since the categories of space and time are the areas of studying physical and spiritual sciences, it was necessary to pay attention to considering these questions in exact sciences such as Physics, Maths etc. Further development of the science of literature is not possible without describing the role of space and time in writing and shaping a literary text. .

  7. Some considerations about literary analysis modern methods from a didactic perspective

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    Marialina Ana García Escobio

    2016-12-01

    Full Text Available This article make it possible a close look to the modern methods of literary analysis, taking as the starting point what the teaching of literature in the joyful context should fulfill in the study of the literary play and the processes of reception and aesthetic statement, as well as the application of the aforementioned methods in the attempt to make the student arrive at rational position; But, at the same time, he/she should feel creator and coauthor of an event that should be lived from a type of special reading done; Herein the importance of a system of methodological work that prepares the professors to contribute from each of the classes to the development of skills for the students´ literary analysis.

  8. Potent anti-proliferative effects against oral and cervical cancers of Thai medicinal plants selected from the Thai/Lanna medicinal plant recipe database "MANOSROI III".

    Science.gov (United States)

    Manosroi, Aranya; Akazawa, Hiroyuki; Pattamapun, Kassara; Kitdamrongtham, Worapong; Akihisa, Toshihiro; Manosroi, Worapaka; Manosroi, Jiradej

    2015-07-01

    Thai/Lanna medicinal plant recipes have been used for the treatment of several diseases including oral and cervical cancers. To investigate anti-proliferative activity on human cervical (HeLa) and oral (KB) cancer cell lines of medicinal plants selected from Thai/Lanna medicinal plant recipe database "MANOSROI III". Twenty-three methanolic plant crude extracts were tested for phytochemicals and anti-proliferative activity on HeLa and KB cell lines for 24 h by the sulforhodamine B (SRB) assay at the doses of 1 × 10(1)-1 × 10(-6 )mg/ml. The nine extracts with the concentrations giving 50% growth inhibition (GI50) lower than 100 µg/ml were further semi-purified by liquid/liquid partition in order to evaluate and enhance the anti-proliferative potency. All extracts contained steroids/triterpenoids, but not xanthones. The methanolic extracts of Gloriosa superba L. (Colchinaceae) root and Albizia chinensis (Osbeck) Merr. (Leguminosae-Mimosoideae) wood gave the highest anti-proliferative activity on HeLa and KB cell lines with the GI50 values of 0.91 (6.0- and 0.31-fold of cisplatin and doxorubicin) and 0.16 µg/ml (28.78- and 82.29-fold of cisplatin and doxorubicin), respectively. Hexane and methanol-water fractions of G. superba exhibited the highest anti-proliferative activity on HeLa and KB cell lines with the GI50 values of 0.15 (37- and 1.9-fold of cisplatin and doxorubicin) and 0.058 µg/ml (77.45- and 221.46-fold of cisplatin and doxorubicin), respectively. This study has demonstrated the potential of plants selected from MANOSROI III database especially G. superba and A. chinensis for further development as anti-oral and cervical cancer agents.

  9. The teacher's role in selecting a methodological approach to the interpretation of a literary work

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    Stakić Mirjana M.

    2016-01-01

    Full Text Available The paper looks at the teacher's role in selecting a methodological approach to the interpretation of a literary work. The choice of methodological approach is dependent on: 1 the semiotic structure of the literary text; 2 the specific educational goals of interpretation; 3 the students' age, psychophysical abilities and knowledge, and 4 the planned circumstances of instruction. In selecting a method of interpretation, the teacher should take into consideration not only these factors, but also contemporary literary theory and its methodological apparatus. This can be a challenging task whose fulfillment does not guarantee that the interpretation will be successful, since the validity and functionality of the methodological approach cannot be established in theory but rather through teaching practice. It is up to the teacher to be creative, because a literary work cannot be interpreted by means of a single method but always through a combination of methods, certain of which have their origins in literary theory. There is a widespread belief among teachers that these methods, which have the status of technical/special methods in literary methodology, cannot be used in the first four grades of elementary school. This paper offers an example illustrating that the interpretive model can be used as early as first grade. A teacher's knowledge, as well as their creativity in selecting a method and their openness to creative methodological combinations and skill in applying them, directly affect the effectiveness of interpretation, either succeeding in developing a fondness for books and reading, or, failing that, resulting in a permanent loss of interest in the world of literature.

  10. Treatment effects of captopril on non-proliferative diabetic retinopathy

    Institute of Scientific and Technical Information of China (English)

    WANG Ning; ZHENG Zhi; JIN Hui-yi; XU Xun

    2012-01-01

    Background Diabetic retinopathy (DR) is one of the most common complications of diabetes.Angiotensin-converting enzyme inhibitor is thought to play an important role in preventing and treating retinal diseases in animal models of DR.The aim of the present study was to investigate the role of angiotensin-converting enzyme inhibitor (ACEI,captopril) in the treatment of patients with non-proliferative DR.Methods Three hundred and seventeen type 2 diabetic patients (88.05% of participants) without or with mild to moderate non-proliferative retinopathy were randomly divided into captopril group (n=202) and placebo group (n=115).All subjects received 24-month follow-up.General clinical examinations,including blood pressure and glycated hemoglobin,as well as comprehensive standardized ophthalmic examinations were performed.Color fundus photography and optical coherence tomography (OCT) were used to grade diabetic retinopathy and detect macular edema respectively.Results The levels of blood pressure and glycated hemoglobin in the two groups of patients remained within the normal range during the entire follow-up and no significant difference was found between the initial and last visits,suggesting that ACEI drugs play a protective role on the DR patients independent of its anti-blood pressure role.DR classification showed that 169 eyes (83.66%) remained unchanged and the DR grade of 33 eyes (16.34%) increased in captopril group,while 84 eyes (73.04%) remained unchanged and the grade of 31 eyes (26.96%) increased in placebo group (P=0.024).Captopril treatment improved macular edema in 55.45% eyes,which was significantly higher than the 37.39% improvement in placebo group (P=0.002).No significant difference was found in the visual acuity between the two groups (P=0.271).Conclusion Captopril can improve or delay the development of DR and macular edema,which can be used in the early treatment of DR patients with type 2 diabetic mellitus.

  11. Proliferative diabetic retinopathy after vitrectomy early factors affect IOP

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    Shi-Bo Liu

    2013-05-01

    Full Text Available AIM:To explore possible causes of early postoperative elevated intraocular pressure caused by proliferative diabetic retinopathy(PDRvitrectomy. METHODS:Totally 72 cases(100 eyeswhich have performed vitrectomy for proliferative diabetic retinopathy were retrospectively analyzed to observe the incidence of postoperative ocular hypertension, and the relevant factors that caused postoperative high intraocular pressure were statistically analyzed. Early postoperative ocular hypertension diagnostic criteria: any time after 2 weeks of non-contact tonometer measured IOP> 25mmHg(1mmHg=0.133kPa. RESULTS:High intraocular pressure after vitrectomy occurred in 27 eyes(27%, the incidence of male and female were 27.27%, 26.79%, the difference was not statistically significant(P>0.05. Eyes filled with balanced liquid filling incidence rate of 30.95%, 6.25%, and the difference was statistically significant(P0.05. Incidences of intraoperative panretinal photocoagulation and additional retinal photocoagulation group were 41%, 20%, and the difference was statistically significant(P<0.05. Preoperative retinopathy of four, five, six groups of incidence were 9.52%, 23.81%, 40.56%, and the groups were statistically significant(P<0.05. Unconsolidated preoperative retinal detachment and retinal detachment incidence rate of 19%, 41%, and the difference was statistically significant(P<0.05. Surgery in the united lens resection with intraoperative unfederated lens the resection group's incidence rate of 34%, 15%, the difference was statistically significant(P<0.05. Logistic regression analysis showed that retinal detachment preoperative and intraoperative intraocular filling were independent risk factors that caused early postoperative ocular hypertension after vitrectomy. CONCLUSION:Post-operative ocular hypertension after PDR vitrectomy is related to preoperative retinal detachment, intraoperative lensectomy, intraoperative intraocular filling, and intraoperative

  12. Spains Dramatic Conquest of the Dutch Republic. Rodenburgh as a Literary Mediator of Spanish Culture

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    Tim Vergeer

    2016-12-01

    Full Text Available Theodore Rodenburgh was in an exceptional position to become a literary mediator of Spanish poetics. He introduced the comedia nueva in the Dutch Republic at the beginning of the seventeenth century. This article investigates specifically how Rodenburgh dealt with Lope de Vega’s poetics, transforming them to make them fit the Dutch literary tradition. Through translation, adaptation and acculturation, the Iberian comedias became Dutch tragicomedies, plays that would become most popular in the Dutch Republic. Rodenburgh’s endeavours mark the initial phase of the transfer of the comedia nueva to the Dutch Republic.

  13. ON FEMALE LITERARY FIGURATIONS IN KAMOV’S TRAVESTY ŽENA (WOMAN

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    Brigita Miloš

    2014-01-01

    Full Text Available The aim of this paper is to point out the perceived particularity of individual literary figurations as thresholds of subversion of the ‘economy of the same’. The suggested reading considers various materialities of the text that can refer to the modes of performative structures, as well as to the interpretations of female gender identity positions. When the ‘essence’ of femininity is questionable and the status of gender related ideals relative, then different possibilities of gender performatives are those that generate gender imagery of this Kamov’s literary text.

  14. Border Crossing in Contemporary Brazilian Culture: Global Perspectives from the Twenty-First Century Literary Scene

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    Cimara Valim de Melo

    2016-06-01

    Full Text Available Abstract: This paper investigates the process of internationalisation of Brazilian literature in the twenty-first century from the perspective of the publishing market. For this, we analyse how Brazil has responded to globalisation and what effects of cultural globalisation can be seen in the Brazilian literary scene, focusing on the novel. Observing the movement of the novelists throughout the globe, the reception of Brazilian literature in the United Kingdom and the relations between art and the literary market in Brazil, we intend to provoke some reflections on Brazilian cultural history in the light of the twenty-first century.

  15. Some considerations about literary analysis modern methods from a didactic perspective

    OpenAIRE

    Marialina Ana García Escobio; Moraima Pérez Barrera; María del Carmen Miló Anillo

    2016-01-01

    This article make it possible a close look to the modern methods of literary analysis, taking as the starting point what the teaching of literature in the joyful context should fulfill in the study of the literary play and the processes of reception and aesthetic statement, as well as the application of the aforementioned methods in the attempt to make the student arrive at rational position; But, at the same time, he/she should feel creator and coauthor of an event that should be lived from ...

  16. Glomerular Damage in Experimental Proliferative Glomerulonephritis Under Glomerular Capillary Hypertension

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    Pei-Rong Wang

    2015-03-01

    Full Text Available Background/Aims: Immunologically and hemodynamically mediated the destruction of glomerular architecture is thought to be the major causes of end-stage renal failure. The purpose of this study is to evaluate the effect of glomerular hypertension on glomerular injury and the progression of glomerular sclerosis after Thy-1 nephritis was induced. Method: Thy-1 nephritis was induced in the stroke-prone spontaneously hypertensive rat strain (SHR-SP (group SP and in age-matched Wistar-Kyoto (WKY (group WKY rats, following unilateral nephrectomy (UNX, and a vehicle was injected alone in UNX SHR-SP as control (group SC. Result: The degree of glomerular damage in response to a single dose of anti-thy-1 antibody, and its functional consequences (eg. proteinuria, diminished GFR are more pronounced in group SP than normotensive group WKY and hypertensive group SC without mesangial cell injury. While normotensive group WKY rats recovered completely from mesangial cell injury on day 28-42, glomeruli in group SP kept on persistent macrophage infiltration, α-SMA expression on day 42-56. In addition, glomerular capillary repair with the GECs was rarely seen in pronouncedly proliferative and sclerostic areas. The incidence of glomerular sclerosis and the level of proteinuria were markedly increased by day 56 in the group SP. Conclusions: Our results demonstrate that glomerular hypertension aggravate glomerular damage and glomerulosclerosis in this model of Thy 1 nephritis.

  17. Subretinal Perfluorocarbon Liquid for Dissection of Proliferative Vitreoretinopathy

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    Jose Dalma-Weiszhausz

    2012-01-01

    Full Text Available Proliferative vitreoretinopathy (PVR is a frequent condition following complex retinal detachments or trauma, and subretinal PVR is a common cause of retinal redetachment. Subretinal PVR removal is challenging and may require creating multiple or large retinotomies, making manipulation of the retina difficult and sometimes hazardous. We propose a novel surgical technique that may facilitate subretinal removal of PVR. After peripheral retinotomy of 180 degrees or greater, perfluorocarbon liquid (PFCL is carefully introduced into the subretinal space as a single bubble which provides space to perform the maneuvers. The PFCL serves as a second hand which folds the retina over, thereby allowing better visualization for safer and easier subretinal PVR removal. PFCL in then removed by direct aspiration as a single bubble while still under balanced salt solution, taking advantage of its high surface tension which prevents leaving bubbles behind. The described technique allows adequate exposure of the subretinal space for proper dissection of difficult-to-reach subretinal PVR. We applied this technique in five patients with chronic retinal detachment, extensive subretinal PVR and poor visual potential. The utilization of subretinal PFCL can assist dissection of subretinal PVR and may be useful in eyes with complicated retinal detachment and poor visual prognosis.

  18. Health assessment of environmental pollutants: proliferative and degenerative diseases

    International Nuclear Information System (INIS)

    Stuart, B.O.

    1988-01-01

    In order to achieve a balanced approach to risk assessment between carcinogenic and non-carcinogenic health effects one must examine the risk of disease or death in the general population exposed to a particular air pollutant that can be related quantitatively to intensity and duration of exposures (National Academy of Sciences, 1983). Such risk assessment should be based upon careful evaluation of scientific findings of dose-response relationships in the chronically exposed population. Quantitative assessment of environmentally produced disease in man has proven to be complex and demanding. A variety of factors play important roles in this task. As an example, there are induction-latency periods for chronic diseases, including cancer, which may range from five to twenty-five years. The diseases themselves, whether proliferative or degenerative, may follow several stages of progression. There is only sparse epidemiological data on serious health effects that may be due to environmental as compared to occupational exposures. Exposures to chemical or radiological air contaminants do not occur singly but to a multiplicity of agents, and disease processes are frequently markedly affected by the interaction of a variety of factors, particularly that of cigarette smoking. There is growing recognition of potentially sensitive subpopulations, including the elderly and the very young, but adequate techniques for assessing the magnitude of increased risks to these groups have not yet been developed

  19. Subretinal Perfluorocarbon Liquid for Dissection of Proliferative Vitreoretinopathy

    Science.gov (United States)

    Dalma-Weiszhausz, Jose; Franco-Cardenas, Valentina; Dalma, Alejandro

    2012-01-01

    Proliferative vitreoretinopathy (PVR) is a frequent condition following complex retinal detachments or trauma, and subretinal PVR is a common cause of retinal redetachment. Subretinal PVR removal is challenging and may require creating multiple or large retinotomies, making manipulation of the retina difficult and sometimes hazardous. We propose a novel surgical technique that may facilitate subretinal removal of PVR. After peripheral retinotomy of 180 degrees or greater, perfluorocarbon liquid (PFCL) is carefully introduced into the subretinal space as a single bubble which provides space to perform the maneuvers. The PFCL serves as a second hand which folds the retina over, thereby allowing better visualization for safer and easier subretinal PVR removal. PFCL in then removed by direct aspiration as a single bubble while still under balanced salt solution, taking advantage of its high surface tension which prevents leaving bubbles behind. The described technique allows adequate exposure of the subretinal space for proper dissection of difficult-to-reach subretinal PVR. We applied this technique in five patients with chronic retinal detachment, extensive subretinal PVR and poor visual potential. The utilization of subretinal PFCL can assist dissection of subretinal PVR and may be useful in eyes with complicated retinal detachment and poor visual prognosis. PMID:23502847

  20. Coordination Skills during Vitrectomy in Treatment of Proliferative Diabetic Retinopathy

    Institute of Scientific and Technical Information of China (English)

    Xuehong Chen; Shanshan Luo; Yanchan Liu

    2014-01-01

    Purpose:.To discuss effective nursing and coordination skills for vitrectomy in the treatment of diabetic retinopathy. Methods: Fifty patients (51 eyes) with diabetic retinopathy required vitrectomy were enrolled in this study..Individual nursing service was delivered by strengthening preoperative preparation, providing psychological nursing, and intraopera-tive observation of the severity of diseases by circulating nurses;meticulous nursing was given postoperatively. Results:All 50 patients underwent surgery successfully..Intra-operatively,.patients had stable physical signs..Five patients had postoperative visual acuity0.3..No complicated infection was seen. Conclusion: For patients diagnosed with proliferative diabetic retinopathy requiring vitrectomy,.full preparations should be made and psychological nursing should be delivered preopera-tively, the severity of diseases and clinical reactions should be closely observed intraoperatively,.and proper processing and nursing measures should be taken postoperatively,.which col-lectively enhance surgical success rate,.decrease surgical com-plications,.and attain favorable treatment efficacy.(Eye Science 2014; 29:55-58).

  1. OM-101 Decreases the Fibrotic Response Associated with Proliferative Vitreoretinopathy

    Science.gov (United States)

    Dvashi, Zeev; Ben-Yaakov, Keren; Weinberg, Tamir; Greenwald, Yoel

    2017-01-01

    Purpose This study aimed to investigate the effect of OM-101 on the fibrotic response occurring in proliferative vitreoretinopathy (PVR) in an animal model. Methods Antifibrotic effect of OM-101 was investigated in vivo. As control, eight weeks old c57black mice underwent intravitreal injection with Hepes (group A) or dispase (0.3 units), to induce retinal detachment (RD) and PVR. The dispase-injected mice were randomly divided into two groups B and C (N = 25 mice); in group C, the eyes were treated with intravitreal injection of OM-101 (3 μl), and group B with PBS, as a control. After additional five days, mice were injected with the same initial treatment. Three days later, mice were euthanized, and the eyes were enucleated and processed for histological analysis. Results Intravitreal injection of dispase caused RD in 64% of the mice in group B, and 93% of those mice had PVR. Only 32% of mice treated with OM-101 and dispase (group C) developed RD, and only 25% of those developed PVR. Conclusions OM-101 was found effective in reducing the incidence of RD and PVR maintaining the normal architecture of the retina. This study suggests that OM-101 is a potentially effective and safe drug for the treatment of PVR patients. PMID:29109865

  2. Automated detection of neovascularization for proliferative diabetic retinopathy screening.

    Science.gov (United States)

    Roychowdhury, Sohini; Koozekanani, Dara D; Parhi, Keshab K

    2016-08-01

    Neovascularization is the primary manifestation of proliferative diabetic retinopathy (PDR) that can lead to acquired blindness. This paper presents a novel method that classifies neovascularizations in the 1-optic disc (OD) diameter region (NVD) and elsewhere (NVE) separately to achieve low false positive rates of neovascularization classification. First, the OD region and blood vessels are extracted. Next, the major blood vessel segments in the 1-OD diameter region are classified for NVD, and minor blood vessel segments elsewhere are classified for NVE. For NVD and NVE classifications, optimal region-based feature sets of 10 and 6 features, respectively, are used. The proposed method achieves classification sensitivity, specificity and accuracy for NVD and NVE of 74%, 98.2%, 87.6%, and 61%, 97.5%, 92.1%, respectively. Also, the proposed method achieves 86.4% sensitivity and 76% specificity for screening images with PDR from public and local data sets. Thus, the proposed NVD and NVE detection methods can play a key role in automated screening and prioritization of patients with diabetic retinopathy.

  3. Wingless promotes proliferative growth in a gradient-independent manner.

    Science.gov (United States)

    Baena-Lopez, Luis Alberto; Franch-Marro, Xavier; Vincent, Jean-Paul

    2009-10-06

    Morphogens form concentration gradients that organize patterns of cells and control growth. It has been suggested that, rather than the intensity of morphogen signaling, it is its gradation that is the relevant modulator of cell proliferation. According to this view, the ability of morphogens to regulate growth during development depends on their graded distributions. Here, we describe an experimental test of this model for Wingless, one of the key organizers of wing development in Drosophila. Maximal Wingless signaling suppresses cellular proliferation. In contrast, we found that moderate and uniform amounts of exogenous Wingless, even in the absence of endogenous Wingless, stimulated proliferative growth. Beyond a few cell diameters from the source, Wingless was relatively constant in abundance and thus provided a homogeneous growth-promoting signal. Although morphogen signaling may act in combination with as yet uncharacterized graded growth-promoting pathways, we suggest that the graded nature of morphogen signaling is not required for proliferation, at least in the developing Drosophila wing, during the main period of growth.

  4. Proliferative Retinopathy in Type 1 Diabetes Is Associated With Cerebral Microbleeds, Which Is Part of Generalized Microangiopathy

    NARCIS (Netherlands)

    Woerdeman, J.P.; van Duinkerken, E.; Wattjes, M.P.; Barkhof, F.; Snoek, F.J.; Moll, A.C.; Klein, M.; de Boer, M.P.; IJzerman, R.G.; Serne, E.H.; Diamant, M.

    2014-01-01

    OBJECTIVE: We investigated whether proliferative diabetic retinopathy in type 1 diabetic patients can be generalized to cerebral small vessel disease and whether it is associated with impaired peripheral microvascular function. RESEARCH DESIGN AND METHODS: Thirty-three patients with proliferative

  5. 78 FR 42106 - Certain TV Programs, Literary Works for TV Production and Episode Guides Pertaining to Same...

    Science.gov (United States)

    2013-07-15

    ... INTERNATIONAL TRADE COMMISSION [Investigation No. 337-TA-886] Certain TV Programs, Literary Works for TV Production and Episode Guides Pertaining to Same; Institution of Investigation Pursuant to 19 U... of certain TV programs, literary works for TV production and episode guides pertaining to same by...

  6. Anti-proliferative effects of Bifidobacterium adolescentis SPM0212 extract on human colon cancer cell lines

    International Nuclear Information System (INIS)

    Lee, Do Kyung; Jang, Seok; Kim, Mi Jin; Kim, Jung Hyun; Chung, Myung Jun; Kim, Kyung Jae; Ha, Nam Joo

    2008-01-01

    Lactic acid bacteria (LAB) are beneficial probiotic organisms that contribute to improved nutrition, microbial balance, and immuno-enhancement of the intestinal tract, as well as anti-tumor activity. The aim of the present work was to study the growth inhibition of tumor cells by butanol extract of Bifidobacterium adolescentis isolated from healthy young Koreans. The anti-proliferative activity of B. adolescentis isolates was assessed by XTT assays on three human colon cancer cell lines (Caco-2, HT-29, and SW480). The effects of B. adolescentis SPM0212 butanol extract on tumor necrosis factor-α (TNF-α) and nitric oxide (NO) production were tested using the murine macrophage RAW 264.7 cell line. The butanol extract of B. adolescentis SPM0212 dose-dependently inhibited the growth of Caco-2, HT-29, and SW480 cells by 70%, 30%, and 40%, respectively, at 200 μg/mL. Additionally, the butanol extract of B. adolescentis SPM0212 induced macrophage activation and significantly increased the production of TNF-α and NO, which regulate immune modulation and are cytotoxic to tumor cells. The butanol extract of B. adolescentis SPM0212 increased activity of the host immune system and may improve human health by helping to prevent colon cancer as a biological response modifier

  7. Current Practices in Instruction in the Literary Braille Code University Personnel Preparation Programs

    Science.gov (United States)

    Rosenblum, L. Penny; Lewis, Sandra; D'Andrea, Frances Mary

    2010-01-01

    University instructors were surveyed to determine the requirements for their literary braille courses. Twenty-one instructors provided information on the textbooks they used; how they determined errors; reading proficiency requirements; and other pertinent information, such as methods of assessing mastery of the production of braille using a…

  8. The Actualization of Literary Learning Model Based on Verbal-Linguistic Intelligence

    Science.gov (United States)

    Hali, Nur Ihsan

    2017-01-01

    This article is inspired by Howard Gardner's concept of linguistic intelligence and also from some authors' previous writings. All of them became the authors' reference in developing ideas on constructing a literary learning model based on linguistic intelligence. The writing of this article is not done by collecting data empirically, but by…

  9. Literary Translation, Translating Culture: The Case of Shahriyar, the Famous Iranian Azeri Poet

    Science.gov (United States)

    Kianbakht, Saijad

    2016-01-01

    A literary translation is a device of art used to release the text from its dependence on prior cultural knowledge (Herzfeld, 2003). The present research investigates the use of pragmatic equivalence in two translations of the Azeri Turkish long poem "Haydar Babaye Salam" by "Shahriyar." Based on Koller's theory of equivalence…

  10. Checkmate: Linguistic and Literary Play in Salman Rushdie's "Haroun and the Sea of Stories"

    Science.gov (United States)

    Bongartz, Christiane; Richey, Esther Gilman

    2010-01-01

    The authors use Noam Chomsky's theories about generative grammar to discuss the notion of linguistic creativity they believe lies at the core of storytelling as Salman Rushdie pictures it in his novel, "Haroun and the Sea of Stories." The production of meaning through the use of narrative helps explain the rules of the literary game,…

  11. The Interdisciplinary Curriculum: A Literary Review and a Manual for Administrators and Teachers.

    Science.gov (United States)

    Smith, Jaimie; Karr-Kidwell, PJ

    The purpose of this paper was to provide a literary review and to create a manual explaining the difference between an interdisciplinary curriculum and other curriculum approaches. An interdisciplinary curriculum is a holistic approach that links the disciplines by emphasizing relationships and connections. A different approach to curriculum…

  12. Readings on Jane Austen. The Greenhaven Press Literary Companion to British Authors.

    Science.gov (United States)

    Swisher, Clarice, Ed.

    Designed for young adults, this book on Jane Austen's novels is one of an anthology series providing accessible resources for students researching great literary lives and works. Contributing writers' essays in the book are taken from a wide variety of sources and are edited to accommodate the reading and comprehension levels of young adults; each…

  13. Fictions of the Writer: A Critical Articulation of Collaborative Writing and Literary Studies.

    Science.gov (United States)

    Haefner, Joel

    In recent years the High Romantic concept of the solitary author has been intensely challenged. Compositionists and various theorists have deconstructed the concept of isolated authorship and critiqued the Romantic notion of individual genius. Meanwhile, the reconstruction of the female literary tradition introduced the question of gender and…

  14. Art-Literary Interface: The Creative Muse of Uche Okeke Through ...

    African Journals Online (AJOL)

    While I attempt to underscore the importance of Igbo forklore to the creative enterprise, as exemplified by Achebe and Okeke, I also emphasize the role of Okeke's drawings and literary landmarks in the institutionalization of an artliterary tradition at the department of Fine and Applied Arts of the University of Nigeria Nsukka.

  15. Analytical Study of the Status of Myth in the Creation of Literary and Artistic Works

    Science.gov (United States)

    Moghaddam, Sedigheh Sherkat; Abai, Andia

    2016-01-01

    The prevalent question raised in literary theories has been the quiddity of literature. However, the question of "what is literature?" is a philosophical issue. On the other hand, the relationship between myth and literature has always been raised by most scholars and many have considered literature a subtype of myths. In this paper,…

  16. English Syllabus Interpretation: The Relationship between Literary Theories and Teacher Beliefs

    Science.gov (United States)

    Ireland, Jill; O'Sullivan, Kerry-Ann; Duchesne, Susan

    2017-01-01

    This paper examines the relationship between the literary theories underpinning an English syllabus and teachers' personal epistemologies and pedagogical beliefs. The study discussed here used semi-structured interviews and an online survey to investigate 50 New South Wales teachers' views of the theoretical basis of a senior English syllabus that…

  17. What Reader-Oriented Literary and Cognitive Theories Have to Give to Composing Theory.

    Science.gov (United States)

    Liebman-Kleine, JoAnne

    In developing an interactive model of composing, this paper discusses three groups of reader-oriented theories, each of which provides composing theorists with some research and theory to use in developing such a model. First the paper discusses the main principle of the literary reader-response theorists--that the meaning and value of texts do…

  18. An Epistemological Justification of the Place of Literary Art in the Curriculum.

    Science.gov (United States)

    Phillips, Ruth Ann

    The purpose of this study was to epistemologically justify the place of literary art in the curriculum by showing that its aesthetic significance gives knowledge that can be communicated in no other terms than its own and that this knowledge is consistent with certain epistemological theories. Using theories of art proposed by Langer and Cassirer,…

  19. The Actualization of Literary Learning Model Based on Verbal-Linguistic Intelligence

    Directory of Open Access Journals (Sweden)

    Nur Ihsan Halil

    2017-10-01

    Full Text Available This article is inspired by Howard Gardner's concept of linguistic intelligence and also from some authors' previous writings. All of them became the authors' reference in developing ideas on constructing a literary learning model based on linguistic intelligence. The writing of this article is not done by collecting data empirically, but by developing and constructing an existing concept, namely the concept of linguistic intelligence, which is disseminated into a literature-based learning of verbal-linguistic intelligence. The purpose of this paper is to answer the question of how to apply the literary learning model based on the verbal-linguistic intelligence. Then, regarding Gardner's concept, the author formulated a literary learning model based on the verbal-linguistic intelligence through a story-telling learning model with five steps namely arguing, discussing, interpreting, speaking, and writing about literary works. In short, the writer draw a conclusion that learning-based models of verbal-linguistic intelligence can be designed with attention into five components namely (1 definition, (2 characteristics, (3 teaching strategy, (4 final learning outcomes, and (5 figures.

  20. ‘It’s Alive!’ New Materialism and Literary Horror

    DEFF Research Database (Denmark)

    Sencindiver, Susan Yi

    2017-01-01

    Pivoting on the primacy of matter as an underexplored question, both new materialist thought and literary Horror’s predilection for probing materialities in lurid detail provide ample purchase for rethinking the matter of matter, and their convergence may open new refreshing lines of inquiry...

  1. Should the Bible Be Taught as a Literary Classic in Public Education?

    Science.gov (United States)

    Malikow, Max

    2010-01-01

    The research question "Should the Bible be taught as a literary classic in public education?" was pursued by a survey of nineteen scholars from three disciplines: education, literature, and law. The collected data served to guide the researcher in the writing of an analytical essay responding to the research question. The research…

  2. The Debate over Literary Tamil versus Standard Spoken Tamil: What Do Teachers Say?

    Science.gov (United States)

    Saravanan, Vanithamani; Lakshmi, Seetha; Caleon, Imelda S.

    2009-01-01

    This study aims to determine the attitudes toward Standard Spoken Tamil (SST) and Literary Tamil (LT) of 46 Tamil teachers in Singapore. The teachers' attitudes were used as an indicator of the acceptance or nonacceptance of SST as a viable option in the teaching of Tamil in the classroom, in which the focus has been largely on LT. The…

  3. RETRACTED: Translating Connotative Meaning in Literary Texts at the University of Petra

    Directory of Open Access Journals (Sweden)

    Akram M. Beiruti

    2013-09-01

    Full Text Available This article is primarily concerned with the investigation of the importance of connotation in translation. The four meanings normally discussed in semantics are denotation, connotation, reference and sense. Denotation is the frame of meaning, which is found in definitions given by dictionaries; while connotation is an additional shade of meaning added to the denotation of a word. Pragmatic meanings play an important role in the interpretation of a literary text. They need to be handled carefully by translators, and are likely not to survive the process of translation. Their meanings are fragile and often culture specific. They may also be highly personal associated with the author himself. In literary translation, meaning can only be accurate to a certain degree, since it is looking for the connotative as well as the denotative meanings. As such the successful translator is aware of the multiple meanings of the word. Whilst the translator has to cope with the different shades of word meanings, which are in non-literary translation, he can achieve anywhere near perfection. It worth mentioning that poetry is the hardest of all literary genres to translate, because it has some linguistic factors to account for (notably sound, rhyme and meter and connotation. Thus the importance of connotation is of utmost importance in translation. which translators have to be aware of.

  4. Discourse on Narrative Research: The Construction Zone--Literary Elements in Narrative Research

    Science.gov (United States)

    Coulter, Cathy A.; Smith, Mary Lee

    2009-01-01

    Narrative research has become part of the landscape of education inquiry, yet its theory and practice are still debated and evolving. This article addresses the construction of narratives using literary elements common to nonfiction and fiction writings. The authors discuss these elements and use four narratives to illustrate them. They address…

  5. Russia's Literary Genius Alexander Pushkin: The Great-Grandson of an African Slave.

    Science.gov (United States)

    Lounsbery, Anne

    2000-01-01

    Alexander Pushkin, Russia's most celebrated literary figure, descended from an African slave. On both parents' sides, he was related to Avram Petrovich Gannibal, who was born to an African prince and abducted to become a slave to a Russian diplomat. Pushkin chose to pride himself on both his aristocratic life and his African ancestry. (SM)

  6. Narrowing Circles : Questions on Autopoiesis and Literary Interpretation after Dietrich Schwanitz

    NARCIS (Netherlands)

    Lippert, Florian

    2009-01-01

    The essay deals with possibilities of relating Niklas Luhmann's systems theory, especially his notion of autopoiesis, to the interpretation of literary texts. Beyond the common description of literature as a social (sub)system, it discusses ideas regarding a specific representativity of literature

  7. Literatura a digitální kultura: Potřebujeme digital literary studies?

    Czech Academy of Sciences Publication Activity Database

    Piorecký, Karel

    2015-01-01

    Roč. 63, č. 6 (2015), s. 935-949 ISSN 0009-0468 R&D Projects: GA ČR GPP406/12/P603 Institutional support: RVO:68378068 Keywords : digital culture * postdigital culture * literary system * digital humanities Subject RIV: AJ - Letters, Mass-media, Audiovision

  8. SGML-Based Markup for Literary Texts: Two Problems and Some Solutions.

    Science.gov (United States)

    Barnard, David; And Others

    1988-01-01

    Identifies the Standard Generalized Markup Language (SGML) as the best basis for a markup standard for encoding literary texts. Outlines solutions to problems using SGML and discusses the problem of maintaining multiple views of a document. Examines several ways of reducing the burden of markups. (GEA)

  9. Semantic Markup for Literary Scholars: How Descriptive Markup Affects the Study and Teaching of Literature.

    Science.gov (United States)

    Campbell, D. Grant

    2002-01-01

    Describes a qualitative study which investigated the attitudes of literary scholars towards the features of semantic markup for primary texts in XML format. Suggests that layout is a vital part of the reading process which implies that the standardization of DTDs (Document Type Definitions) should extend to styling as well. (Author/LRW)

  10. LITERARY THEMES IN ITALIAN PERIODICALS IN RIJEKA FROM 1900 TO 1919

    Directory of Open Access Journals (Sweden)

    Dolores Miškulin

    2013-01-01

    Full Text Available Despite the abundance of periodicals in Italian language in Rijeka in the second half of the 19th century and early 20th century, their comprehensive and systematic research together with their modern and objective evaluation is still insufficient. With the aim of contributing to the elucidation and analysis of under-studied Italian publications in Rijeka, we have tried to consider from the contemporary point of view the context in which the subject of our interest appears, to study the available written documents, and to evaluate the facts of literary phenomena within a given corpus. We have tried to substantiate by examples the thesis that literary themes in our local newspapers and magazines of Italian language expression, besides further exploring the Italian literary heritage, have contributed to our overall cultural events through the opening of aesthetic horizons of readers and a number of authors, and have largely contributed to the intertwining of the two cultures. Through testing, systematization and classification of literary topics, we concluded that newspapers and magazines in Rijeka, as the most important medium of the historical period that we examined, have had a significant and dynamic part in the process that led to the gradual change of mindset, views on society and art, and an overall way of thinking and action. In our opinion, through our contribution we have tried to reconstruct from oblivion a valuable segment of Rijeka's cultural heritage.

  11. Primo Levi and the Periodic Table: Teaching Chemistry Using A Literary Text (Excerpt)

    Science.gov (United States)

    Osorio, Viktoria Klara Lakatos; Tiedemann, Peter Wilhelm; Porto, Paulo Alves

    2007-01-01

    The excerpts from The Periodic Table book written by Primo Levi is discussed related to chemical concepts. The use of a literary text as a starting point of discussions of chemical concepts has allowed the integration of various topics covered in separate courses of the undergraduate program in chemistry.

  12. Combining Machine Learning and Natural Language Processing to Assess Literary Text Comprehension

    Science.gov (United States)

    Balyan, Renu; McCarthy, Kathryn S.; McNamara, Danielle S.

    2017-01-01

    This study examined how machine learning and natural language processing (NLP) techniques can be leveraged to assess the interpretive behavior that is required for successful literary text comprehension. We compared the accuracy of seven different machine learning classification algorithms in predicting human ratings of student essays about…

  13. Literature as a Network: Creative-Writing Scholarship in Literary Magazines

    Science.gov (United States)

    Green, Harriett E.

    2014-01-01

    With the increase in undergraduate and graduate programs for creative writing at institutions of higher education in North America, literary journals and magazines now serve as leading scholarly publishing outlets and research resources for creative-writing faculty and students. This study analyzes ten years of citations from nineteen leading…

  14. latin American literary testimony: historical foreshadowing of gender in the revolutionary discourse of the sixties

    Directory of Open Access Journals (Sweden)

    Victoria García

    2015-06-01

    Full Text Available The foundation of testimonio in Latin American literary field, initiated at the end of the ‘60, makes part of the institutionalization of the Cuban revolution, process where its projection to the rest of Latin America constitued a central problem. This paper studies political preconditions of testimonio. In particular, it analizes certain aspects of Cuban revolutionary discourse that anticipate features eventually developed by the literary genre, in the ways the relation between literature and politics is represented, and in the subjects of discourse that are proposed as embodiments of such relation. The paper introduces the question of Cuban revolution, as regards the exemplary status it acquired in Latin America during the sixties. Then, it examines the literary positioning represented by testimonio, as the corollary of a reflexive reconsideration operated by some Latin American writers and critics, concerning their historical role. Finally, it considers three representative documents of Cuban revolution and its continental projection: History will absolve me, by Fidel Castro, and Reminiscences of the Cuban revolutionary war and Bolivian diary, by Ernesto Guevara. We show the textual configuration of a revolutionary subject whose legitimity emerges not only from a political experience which testimony enunciates, but also from particular ways of living and representing literature in the context of a revolutionary practice. In the end of the sixties, the continental literary field would reaffirm such features as its discourse legitimating criteria, during the institutionalization of testimonio as its privileged genre.

  15. The Necessity of the Literary Tradition: Gabriel Garcia Marquez's "One-Hundred Years of Solitude."

    Science.gov (United States)

    Jupp, James C.

    2000-01-01

    Argues that literature from other countries, taught as multicultural literature, must be taught in the context of its own literary tradition in order to provide high-quality academic instruction. Offers an example with Gabriel Garcia Marquez's "One-Hundred Years of Solitude" to show how teaching multicultural literature can live up to…

  16. Readings on Ernest Hemingway. The Greenhaven Press Literary Companion to American Authors.

    Science.gov (United States)

    de Koster, Katie, Ed.

    Intended as an accessible resource for students researching America's greatest literary figures, this collection of essays about Ernest Hemingway's (1899-1961) work contains an in-depth biography and essays taken from a wide variety of sources. The essays are edited to accommodate the reading and comprehension levels of young adults; each essay is…

  17. Pupils' Knowledge and Spoken Literary Response beyond Polite Meaningless Words: Studying Yeats's "Easter, 1916"

    Science.gov (United States)

    Gordon, John

    2016-01-01

    This article presents research exploring the knowledge pupils bring to texts introduced to them for literary study, how they share knowledge through talk, and how it is elicited by the teacher in the course of an English lesson. It sets classroom discussion in a context where new examination requirements diminish the relevance of social, cultural…

  18. Editing Identity: Literary Anthologies and the Construction of the Author in Meiji Japan

    Science.gov (United States)

    Des Jardin, Molly Catherine

    2012-01-01

    "Editing Identity: Literary Anthologies and the Construction of the Author in Meiji Japan" problematizes widespread acceptance of anthologies of authors' "complete works" as both transparent and authoritative compendia of Japanese literature. In the Meiji period (1868-1912), they enjoyed a sudden boom in popularity and have…

  19. Framing Egypt : Roman literary perceptions of Egypt from Cicero to Juvenal

    NARCIS (Netherlands)

    Leemreize, M.E.C.

    2016-01-01

    This is a comprehensive study of Roman literary references to Egypt without preference for one particular period, author or subject, in contrast to most previous scholarship. In doing so, it shows that these references vary greatly, are context-dependent, and cannot be rightly understood when

  20. Readings on the Tragedies of William Shakespeare. The Greenhaven Press Literary Companion to British Authors.

    Science.gov (United States)

    Swisher, Clarice, Ed.

    Designed for young adults, this book on William Shakespeare's tragedies is one of an anthology series providing accessible resources for students researching great literary lives and works. Contributing writers' essays in the book are taken from a wide variety of sources and are edited to accommodate the reading and comprehension levels of young…